3D high spectral and spatial resolution imaging of ex vivo mouse brain

Energy Technology Data Exchange (ETDEWEB)

Foxley, Sean, E-mail: sean.foxley@ndcn.ox.ac.uk; Karczmar, Gregory S. [Department of Radiology, University of Chicago, Chicago, Illinois 60637 (United States); Domowicz, Miriam [Department of Pediatrics, University of Chicago, Chicago, Illinois 60637 (United States); Schwartz, Nancy [Department of Pediatrics, Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637 (United States)

2015-03-15

Purpose: Widely used MRI methods show brain morphology both in vivo and ex vivo at very high resolution. Many of these methods (e.g., T{sub 2}{sup *}-weighted imaging, phase-sensitive imaging, or susceptibility-weighted imaging) are sensitive to local magnetic susceptibility gradients produced by subtle variations in tissue composition. However, the spectral resolution of commonly used methods is limited to maintain reasonable run-time combined with very high spatial resolution. Here, the authors report on data acquisition at increased spectral resolution, with 3-dimensional high spectral and spatial resolution MRI, in order to analyze subtle variations in water proton resonance frequency and lineshape that reflect local anatomy. The resulting information compliments previous studies based on T{sub 2}{sup *} and resonance frequency. Methods: The proton free induction decay was sampled at high resolution and Fourier transformed to produce a high-resolution water spectrum for each image voxel in a 3D volume. Data were acquired using a multigradient echo pulse sequence (i.e., echo-planar spectroscopic imaging) with a spatial resolution of 50 × 50 × 70 μm{sup 3} and spectral resolution of 3.5 Hz. Data were analyzed in the spectral domain, and images were produced from the various Fourier components of the water resonance. This allowed precise measurement of local variations in water resonance frequency and lineshape, at the expense of significantly increased run time (16–24 h). Results: High contrast T{sub 2}{sup *}-weighted images were produced from the peak of the water resonance (peak height image), revealing a high degree of anatomical detail, specifically in the hippocampus and cerebellum. In images produced from Fourier components of the water resonance at −7.0 Hz from the peak, the contrast between deep white matter tracts and the surrounding tissue is the reverse of the contrast in water peak height images. This indicates the presence of a shoulder in

Ultra-wideband spectral analysis using S2 technology

International Nuclear Information System (INIS)

Krishna Mohan, R.; Chang, T.; Tian, M.; Bekker, S.; Olson, A.; Ostrander, C.; Khallaayoun, A.; Dollinger, C.; Babbitt, W.R.; Cole, Z.; Reibel, R.R.; Merkel, K.D.; Sun, Y.; Cone, R.; Schlottau, F.; Wagner, K.H.

2007-01-01

This paper outlines the efforts to develop an ultra-wideband spectrum analyzer that takes advantage of the broad spectral response and fine spectral resolution (∼25 kHz) of spatial-spectral (S2) materials. The S2 material can process the full spectrum of broadband microwave transmissions, with adjustable time apertures (down to 100 μs) and fast update rates (up to 1 kHz). A cryogenically cooled Tm:YAG crystal that operates on microwave signals modulated onto a stabilized optical carrier at 793 nm is used as the core for the spectrum analyzer. Efforts to develop novel component technologies that enhance the performance of the system and meet the application requirements are discussed, including an end-to-end device model for parameter optimization. We discuss the characterization of new ultra-wide bandwidth S2 materials. Detection and post-processing module development including the implementation of a novel spectral recovery algorithm using field programmable gate array technology (FPGA) is also discussed

Ultra-wideband spectral analysis using S2 technology

Energy Technology Data Exchange (ETDEWEB)

Krishna Mohan, R. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States)]. E-mail: krishna@spectrum.montana.edu; Chang, T. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); Tian, M. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); Department of Physics, Montana State University, Bozeman, MT 59717 (United States); Bekker, S. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); Olson, A. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); Ostrander, C. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); Khallaayoun, A. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); Dollinger, C. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); Babbitt, W.R. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); Department of Physics, Montana State University, Bozeman, MT 59717 (United States); Cole, Z. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); S2 Corporation, Bozeman, MT 59718 (United States); Reibel, R.R. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); S2 Corporation, Bozeman, MT 59718 (United States); Merkel, K.D. [Spectrum Lab, Montana State University, Bozeman, MT 59717 (United States); S2 Corporation, Bozeman, MT 59718 (United States); Sun, Y. [Department of Physics, Montana State University, Bozeman, MT 59717 (United States); Cone, R. [Department of Physics, Montana State University, Bozeman, MT 59717 (United States); Schlottau, F. [University of Colorado, Boulder, CO 80309 (United States); Wagner, K.H. [University of Colorado, Boulder, CO 80309 (United States)

2007-11-15

This paper outlines the efforts to develop an ultra-wideband spectrum analyzer that takes advantage of the broad spectral response and fine spectral resolution ({approx}25 kHz) of spatial-spectral (S2) materials. The S2 material can process the full spectrum of broadband microwave transmissions, with adjustable time apertures (down to 100 {mu}s) and fast update rates (up to 1 kHz). A cryogenically cooled Tm:YAG crystal that operates on microwave signals modulated onto a stabilized optical carrier at 793 nm is used as the core for the spectrum analyzer. Efforts to develop novel component technologies that enhance the performance of the system and meet the application requirements are discussed, including an end-to-end device model for parameter optimization. We discuss the characterization of new ultra-wide bandwidth S2 materials. Detection and post-processing module development including the implementation of a novel spectral recovery algorithm using field programmable gate array technology (FPGA) is also discussed.

Monte Carlo Simulations of Ultra-High Energy Resolution Gamma Detectors for Nuclear Safeguards

International Nuclear Information System (INIS)

Robles, A.; Drury, O.B.; Friedrich, S.

2009-01-01

Ultra-high energy resolution superconducting gamma-ray detectors can improve the accuracy of non-destructive analysis for unknown radioactive materials. These detectors offer an order of magnitude improvement in resolution over conventional high purity germanium detectors. The increase in resolution reduces errors from line overlap and allows for the identification of weaker gamma-rays by increasing the magnitude of the peaks above the background. In order to optimize the detector geometry and to understand the spectral response function Geant4, a Monte Carlo simulation package coded in C++, was used to model the detectors. Using a 1 mm 3 Sn absorber and a monochromatic gamma source, different absorber geometries were tested. The simulation was expanded to include the Cu block behind the absorber and four layers of shielding required for detector operation at 0.1 K. The energy spectrum was modeled for an Am-241 and a Cs-137 source, including scattering events in the shielding, and the results were compared to experimental data. For both sources the main spectral features such as the photopeak, the Compton continuum, the escape x-rays and the backscatter peak were identified. Finally, the low energy response of a Pu-239 source was modeled to assess the feasibility of Pu-239 detection in spent fuel. This modeling of superconducting detectors can serve as a guide to optimize the configuration in future spectrometer designs.

High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates.

Science.gov (United States)

Kolb, Jan Philip; Pfeiffer, Tom; Eibl, Matthias; Hakert, Hubertus; Huber, Robert

2018-01-01

We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2∙ 417 kHz  =  834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our setup lies at 5.9 µm axial resolution. In vivo MHz-OCT imaging of human retina is performed and the image quality is compared to the previous results acquired with 70 nm sweep range, as well as to existing spectral domain OCT data with 2.1 µm axial resolution from literature. We identify benefits of the higher resolution, for example the improved visualization of small blood vessels in the retina besides several others.

Ultra high spatial and temporal resolution breast imaging at 7T.

Science.gov (United States)

van de Bank, B L; Voogt, I J; Italiaander, M; Stehouwer, B L; Boer, V O; Luijten, P R; Klomp, D W J

2013-04-01

There is a need to obtain higher specificity in the detection of breast lesions using MRI. To address this need, Dynamic Contrast-Enhanced (DCE) MRI has been combined with other structural and functional MRI techniques. Unfortunately, owing to time constraints structural images at ultra-high spatial resolution can generally not be obtained during contrast uptake, whereas the relatively low spatial resolution of functional imaging (e.g. diffusion and perfusion) limits the detection of small lesions. To be able to increase spatial as well as temporal resolution simultaneously, the sensitivity of MR detection needs to increase as well as the ability to effectively accelerate the acquisition. The required gain in signal-to-noise ratio (SNR) can be obtained at 7T, whereas acceleration can be obtained with high-density receiver coil arrays. In this case, morphological imaging can be merged with DCE-MRI, and other functional techniques can be obtained at higher spatial resolution, and with less distortion [e.g. Diffusion Weighted Imaging (DWI)]. To test the feasibility of this concept, we developed a unilateral breast coil for 7T. It comprises a volume optimized dual-channel transmit coil combined with a 30-channel receive array coil. The high density of small coil elements enabled efficient acceleration in any direction to acquire ultra high spatial resolution MRI of close to 0.6 mm isotropic detail within a temporal resolution of 69 s, high spatial resolution MRI of 1.5 mm isotropic within an ultra high temporal resolution of 6.7 s and low distortion DWI at 7T, all validated in phantoms, healthy volunteers and a patient with a lesion in the right breast classified as Breast Imaging Reporting and Data System (BI-RADS) IV. Copyright © 2012 John Wiley & Sons, Ltd.

Ultra-high resolution coded wavefront sensor

KAUST Repository

Wang, Congli

2017-06-08

Wavefront sensors and more general phase retrieval methods have recently attracted a lot of attention in a host of application domains, ranging from astronomy to scientific imaging and microscopy. In this paper, we introduce a new class of sensor, the Coded Wavefront Sensor, which provides high spatio-temporal resolution using a simple masked sensor under white light illumination. Specifically, we demonstrate megapixel spatial resolution and phase accuracy better than 0.1 wavelengths at reconstruction rates of 50 Hz or more, thus opening up many new applications from high-resolution adaptive optics to real-time phase retrieval in microscopy.

Extended-range high-resolution dynamical downscaling over a continental-scale spatial domain with atmospheric and surface nudging

Science.gov (United States)

Husain, S. Z.; Separovic, L.; Yu, W.; Fernig, D.

2014-12-01

Extended-range high-resolution mesoscale simulations with limited-area atmospheric models when applied to downscale regional analysis fields over large spatial domains can provide valuable information for many applications including the weather-dependent renewable energy industry. Long-term simulations over a continental-scale spatial domain, however, require mechanisms to control the large-scale deviations in the high-resolution simulated fields from the coarse-resolution driving fields. As enforcement of the lateral boundary conditions is insufficient to restrict such deviations, large scales in the simulated high-resolution meteorological fields are therefore spectrally nudged toward the driving fields. Different spectral nudging approaches, including the appropriate nudging length scales as well as the vertical profiles and temporal relaxations for nudging, have been investigated to propose an optimal nudging strategy. Impacts of time-varying nudging and generation of hourly analysis estimates are explored to circumvent problems arising from the coarse temporal resolution of the regional analysis fields. Although controlling the evolution of the atmospheric large scales generally improves the outputs of high-resolution mesoscale simulations within the surface layer, the prognostically evolving surface fields can nevertheless deviate from their expected values leading to significant inaccuracies in the predicted surface layer meteorology. A forcing strategy based on grid nudging of the different surface fields, including surface temperature, soil moisture, and snow conditions, toward their expected values obtained from a high-resolution offline surface scheme is therefore proposed to limit any considerable deviation. Finally, wind speed and temperature at wind turbine hub height predicted by different spectrally nudged extended-range simulations are compared against observations to demonstrate possible improvements achievable using higher spatiotemporal

A comparative study of noise in supercontinuum light sources for ultra-high resolution optical coherence tomography

DEFF Research Database (Denmark)

Maria J., Sanjuan-Ferrer,; Bravo Gonzalo, Ivan; Bondu, Magalie

2017-01-01

Supercontinuum (SC) light is a well-established technology, which finds applications in several domains ranging from chemistry to material science and imaging systems [1-2]. More specifically, its ultra-wide optical bandwidth and high average power make it an ideal tool for Optical Coherence...... Tomography (OCT). Over the last 5 years, numerous examples have demonstrated its high potential [3-4] in this context. However, SC light sources present pulse-to-pulse intensity variation that can limit the performance of any OCT system [5] by degrading their signal to noise ratio (SNR). To this goal, we...... have studied and compared the noise of several SC light sources and evaluated how their noise properties affect the performance of Ultra-High Resolution OCT (UHR-OCT) at 1300 nm. We have measured several SC light sources with different parameters (pulse length, energy, seed repetition rate, etc.). We...

a Spatio-Spectral Camera for High Resolution Hyperspectral Imaging

Science.gov (United States)

Livens, S.; Pauly, K.; Baeck, P.; Blommaert, J.; Nuyts, D.; Zender, J.; Delauré, B.

2017-08-01

Imaging with a conventional frame camera from a moving remotely piloted aircraft system (RPAS) is by design very inefficient. Less than 1 % of the flying time is used for collecting light. This unused potential can be utilized by an innovative imaging concept, the spatio-spectral camera. The core of the camera is a frame sensor with a large number of hyperspectral filters arranged on the sensor in stepwise lines. It combines the advantages of frame cameras with those of pushbroom cameras. By acquiring images in rapid succession, such a camera can collect detailed hyperspectral information, while retaining the high spatial resolution offered by the sensor. We have developed two versions of a spatio-spectral camera and used them in a variety of conditions. In this paper, we present a summary of three missions with the in-house developed COSI prototype camera (600-900 nm) in the domains of precision agriculture (fungus infection monitoring in experimental wheat plots), horticulture (crop status monitoring to evaluate irrigation management in strawberry fields) and geology (meteorite detection on a grassland field). Additionally, we describe the characteristics of the 2nd generation, commercially available ButterflEYE camera offering extended spectral range (475-925 nm), and we discuss future work.

A SPATIO-SPECTRAL CAMERA FOR HIGH RESOLUTION HYPERSPECTRAL IMAGING

Directory of Open Access Journals (Sweden)

S. Livens

2017-08-01

Full Text Available Imaging with a conventional frame camera from a moving remotely piloted aircraft system (RPAS is by design very inefficient. Less than 1 % of the flying time is used for collecting light. This unused potential can be utilized by an innovative imaging concept, the spatio-spectral camera. The core of the camera is a frame sensor with a large number of hyperspectral filters arranged on the sensor in stepwise lines. It combines the advantages of frame cameras with those of pushbroom cameras. By acquiring images in rapid succession, such a camera can collect detailed hyperspectral information, while retaining the high spatial resolution offered by the sensor. We have developed two versions of a spatio-spectral camera and used them in a variety of conditions. In this paper, we present a summary of three missions with the in-house developed COSI prototype camera (600–900 nm in the domains of precision agriculture (fungus infection monitoring in experimental wheat plots, horticulture (crop status monitoring to evaluate irrigation management in strawberry fields and geology (meteorite detection on a grassland field. Additionally, we describe the characteristics of the 2nd generation, commercially available ButterflEYE camera offering extended spectral range (475–925 nm, and we discuss future work.

Motivation for an SSC detector with ultra-high resolution photon detection

International Nuclear Information System (INIS)

Gunion, J.F.; Kane, G.

1992-01-01

It is well known that incorporating ultra-high resolution photon detection into a general purpose detector for the SSC will be extremely difficult. The authors will argue that the physics signals that could be missed without such resolution are of such importance that a special purpose detector designed specifically for photon final state modes should be constructed, if sufficient resolution cannot be achieved with general purpose detectors. The potentially great value of these signals as a probe of extremely high mass scales is stressed

Design and Implementation of Wideband Exciter for an Ultra-high Resolution Airborne SAR System

Directory of Open Access Journals (Sweden)

Jia Ying-xin

2013-03-01

Full Text Available According to an ultra-high resolution airborne SAR system with better than 0.1 m resolution, a wideband Linear Frequency Modulated (LFM pulse compression exciter with 14.8 GHz carrier and 3.2 GHz bandwidth is designed and implemented. The selection of signal generation scheme and some key technique points for wideband LFM waveform is presented in detail. Then, an acute test and analysis of the LFM signal is performed. The final airborne experiments demonstrate the validity of the LFM source which is one of the subsystems in an ultra-high resolution airborne SAR system.

High spectral resolution X-ray observations of AGN

NARCIS (Netherlands)

Kaastra, J.S.

2008-01-01

brief overview of some highlights of high spectral resolution X-ray observations of AGN is given, mainly obtained with the RGS of XMM-Newton. Future prospects for such observations with XMM-Newton are given.

Extended-Range High-Resolution Dynamical Downscaling over a Continental-Scale Domain

Science.gov (United States)

Husain, S. Z.; Separovic, L.; Yu, W.; Fernig, D.

2014-12-01

High-resolution mesoscale simulations, when applied for downscaling meteorological fields over large spatial domains and for extended time periods, can provide valuable information for many practical application scenarios including the weather-dependent renewable energy industry. In the present study, a strategy has been proposed to dynamically downscale coarse-resolution meteorological fields from Environment Canada's regional analyses for a period of multiple years over the entire Canadian territory. The study demonstrates that a continuous mesoscale simulation over the entire domain is the most suitable approach in this regard. Large-scale deviations in the different meteorological fields pose the biggest challenge for extended-range simulations over continental scale domains, and the enforcement of the lateral boundary conditions is not sufficient to restrict such deviations. A scheme has therefore been developed to spectrally nudge the simulated high-resolution meteorological fields at the different model vertical levels towards those embedded in the coarse-resolution driving fields derived from the regional analyses. A series of experiments were carried out to determine the optimal nudging strategy including the appropriate nudging length scales, nudging vertical profile and temporal relaxation. A forcing strategy based on grid nudging of the different surface fields, including surface temperature, soil-moisture, and snow conditions, towards their expected values obtained from a high-resolution offline surface scheme was also devised to limit any considerable deviation in the evolving surface fields due to extended-range temporal integrations. The study shows that ensuring large-scale atmospheric similarities helps to deliver near-surface statistical scores for temperature, dew point temperature and horizontal wind speed that are better or comparable to the operational regional forecasts issued by Environment Canada. Furthermore, the meteorological fields

Ultra high resolution soft x-ray tomography

International Nuclear Information System (INIS)

Haddad, W.S.; Trebes, J.E.; Goodman, D.M.

1995-01-01

Ultra high resolution three dimensional images of a microscopic test object were made with soft x-rays using a scanning transmission x-ray microscope. The test object consisted of two different patterns of gold bars on silicon nitride windows that were separated by ∼5μm. A series of nine 2-D images of the object were recorded at angles between -50 to +55 degrees with respect to the beam axis. The projections were then combined tomographically to form a 3-D image by means of an algebraic reconstruction technique (ART) algorithm. A transverse resolution of ∼1000 Angstrom was observed. Artifacts in the reconstruction limited the overall depth resolution to ∼6000 Angstrom, however some features were clearly reconstructed with a depth resolution of ∼1000 Angstrom. A specially modified ART algorithm and a constrained conjugate gradient (CCG) code were also developed as improvements over the standard ART algorithm. Both of these methods made significant improvements in the overall depth resolution bringing it down to ∼1200 Angstrom overall. Preliminary projection data sets were also recorded with both dry and re-hydrated human sperm cells over a similar angular range

Ultra high resolution soft x-ray tomography

International Nuclear Information System (INIS)

Haddad, W.S.; Trebes, J.E.; Goodman, D.M.; Lee, H.R.; McNulty, I.; Zalensky, A.O.

1995-01-01

Ultra high resolution three dimensional images of a microscopic test object were made with soft x-rays using a scanning transmission x-ray microscope. The test object consisted of two different patterns of gold bars on silicon nitride windows that were separated by ∼5 microm. A series of nine 2-D images of the object were recorded at angles between -50 to +55 degrees with respect to the beam axis. The projections were then combined tomographically to form a 3-D image by means of an algebraic reconstruction technique (ART) algorithm. A transverse resolution of ∼ 1,000 angstrom was observed. Artifacts in the reconstruction limited the overall depth resolution to ∼ 6,000 angstrom, however some features were clearly reconstructed with a depth resolution of ∼ 1,000 angstrom. A specially modified ART algorithm and a constrained conjugate gradient (CCG) code were also developed as improvements over the standard ART algorithm. Both of these methods made significant improvements in the overall depth resolution, bringing it down to ∼ 1,200 angstrom overall. Preliminary projection data sets were also recorded with both dry and re-hydrated human sperm cells over a similar angular range

Time-resolved High Spectral Resolution Observation of 2MASSW J0746425+200032AB

Energy Technology Data Exchange (ETDEWEB)

Wang, Ji; Mawet, Dimitri [Department of Astronomy, California Institute of Technology, MC 249-17, 1200 E. California Boulevard, Pasadena, CA 91106 (United States); Prato, Lisa, E-mail: ji.wang@caltech.edu [Lowell Observatory, 1400 West Mars Hill Road, Flagstaff, AZ 86001 (United States)

2017-03-20

Many brown dwarfs (BDs) exhibit photometric variability at levels from tenths to tens of percents. The photometric variability is related to magnetic activity or patchy cloud coverage, characteristic of BDs near the L–T transition. Time-resolved spectral monitoring of BDs provides diagnostics of cloud distribution and condensate properties. However, current time-resolved spectral studies of BDs are limited to low spectral resolution ( R ∼ 100) with the exception of the study of Luhman 16 AB at a resolution of 100,000 using the VLT+CRIRES. This work yielded the first map of BD surface inhomogeneity, highlighting the importance and unique contribution of high spectral resolution observations. Here, we report on the time-resolved high spectral resolution observations of a nearby BD binary, 2MASSW J0746425+200032AB. We find no coherent spectral variability that is modulated with rotation. Based on simulations, we conclude that the coverage of a single spot on 2MASSW J0746425+200032AB is smaller than 1% or 6.25% if spot contrast is 50% or 80% of its surrounding flux, respectively. Future high spectral resolution observations aided by adaptive optics systems can put tighter constraints on the spectral variability of 2MASSW J0746425+200032AB and other nearby BDs.

Extension of least squares spectral resolution algorithm to high-resolution lipidomics data

Energy Technology Data Exchange (ETDEWEB)

Zeng, Ying-Xu [Department of Chemistry, University of Bergen, PO Box 7803, N-5020 Bergen (Norway); Mjøs, Svein Are, E-mail: svein.mjos@kj.uib.no [Department of Chemistry, University of Bergen, PO Box 7803, N-5020 Bergen (Norway); David, Fabrice P.A. [Bioinformatics and Biostatistics Core Facility, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL) and Swiss Institute of Bioinformatics (SIB), Lausanne (Switzerland); Schmid, Adrien W. [Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)

2016-03-31

Lipidomics, which focuses on the global study of molecular lipids in biological systems, has been driven tremendously by technical advances in mass spectrometry (MS) instrumentation, particularly high-resolution MS. This requires powerful computational tools that handle the high-throughput lipidomics data analysis. To address this issue, a novel computational tool has been developed for the analysis of high-resolution MS data, including the data pretreatment, visualization, automated identification, deconvolution and quantification of lipid species. The algorithm features the customized generation of a lipid compound library and mass spectral library, which covers the major lipid classes such as glycerolipids, glycerophospholipids and sphingolipids. Next, the algorithm performs least squares resolution of spectra and chromatograms based on the theoretical isotope distribution of molecular ions, which enables automated identification and quantification of molecular lipid species. Currently, this methodology supports analysis of both high and low resolution MS as well as liquid chromatography-MS (LC-MS) lipidomics data. The flexibility of the methodology allows it to be expanded to support more lipid classes and more data interpretation functions, making it a promising tool in lipidomic data analysis. - Highlights: • A flexible strategy for analyzing MS and LC-MS data of lipid molecules is proposed. • Isotope distribution spectra of theoretically possible compounds were generated. • High resolution MS and LC-MS data were resolved by least squares spectral resolution. • The method proposed compounds that are likely to occur in the analyzed samples. • The proposed compounds matched results from manual interpretation of fragment spectra.

Extension of least squares spectral resolution algorithm to high-resolution lipidomics data

International Nuclear Information System (INIS)

Zeng, Ying-Xu; Mjøs, Svein Are; David, Fabrice P.A.; Schmid, Adrien W.

2016-01-01

Lipidomics, which focuses on the global study of molecular lipids in biological systems, has been driven tremendously by technical advances in mass spectrometry (MS) instrumentation, particularly high-resolution MS. This requires powerful computational tools that handle the high-throughput lipidomics data analysis. To address this issue, a novel computational tool has been developed for the analysis of high-resolution MS data, including the data pretreatment, visualization, automated identification, deconvolution and quantification of lipid species. The algorithm features the customized generation of a lipid compound library and mass spectral library, which covers the major lipid classes such as glycerolipids, glycerophospholipids and sphingolipids. Next, the algorithm performs least squares resolution of spectra and chromatograms based on the theoretical isotope distribution of molecular ions, which enables automated identification and quantification of molecular lipid species. Currently, this methodology supports analysis of both high and low resolution MS as well as liquid chromatography-MS (LC-MS) lipidomics data. The flexibility of the methodology allows it to be expanded to support more lipid classes and more data interpretation functions, making it a promising tool in lipidomic data analysis. - Highlights: • A flexible strategy for analyzing MS and LC-MS data of lipid molecules is proposed. • Isotope distribution spectra of theoretically possible compounds were generated. • High resolution MS and LC-MS data were resolved by least squares spectral resolution. • The method proposed compounds that are likely to occur in the analyzed samples. • The proposed compounds matched results from manual interpretation of fragment spectra.

Ultra-broadband THz time-domain spectroscopy of common polymers using THz air photonics

DEFF Research Database (Denmark)

D’Angelo, Francesco; Mics, Zoltán; Bonn, Mischa

2014-01-01

-domain spectrometer employing air-photonics for the generation and detection of single-cycle sub-50 fs THz transients. The time domain measurements provide direct access to both the absorption and refractive index spectra. The polymers LDPE and TOPAS® demonstrate negligible absorption and spectrally-flat refractive...... index across the entire spectroscopy window, revealing the high potential of these polymers for applications in THz photonics such as ultra-broadband polymer-based dielectric mirrors, waveguides, and fibers. Resonant high-frequency polar vibrational modes are observed and assigned in polymers PA6...... and PTFE, and their dielectric functions in the complete frequency window 2-15 THz are theoretically reproduced. Our results demonstrate the potential of ultrabroadband air-photonics-based THz time domain spectroscopy as a valuable analytic tool for materials science....

Correction of spectral and temporal phases for ultra-intense lasers; Correction des phases spectrale et temporelle pour les lasers ultra-intenses

Energy Technology Data Exchange (ETDEWEB)

Salmon, E

2000-12-15

The discovery of new regimes of interaction between laser and matter requires to produce laser pulses presenting higher luminous flux density. The only solutions that allow us to reach important power (about ten peta-watts) imply the correction of non-linear effects before compressing the laser pulse so that we do not transfer the phase modulation to the amplitude modulation. The aim of this work is the correction of the spectral phase through the modulation of the temporal phase. The first chapter is dedicated to the review of the physical phenomena involved in the interaction of ultra-intense laser pulse with matter. The peta-watt laser operating on the LIL (integrated laser line), the prototype line of the Megajoule Laser, is described in the second chapter. The third chapter presents the method used and optimized for getting an absolute measurement of the spectral phase in our experimental configuration. The fourth chapter details the analogy existing between the spatial domain and the temporal domain particularly between diffraction and dispersion. This analogy has allowed us to benefit from the knowledge cumulated in the spatial domain, particularly the treatment of the aberrations and their impact on the focal spot and to use it in the temporal domain. The principle of the phase correction is exposed in the fifth chapter. We have formalized the correspondence of the phase modulation between temporal domain and the spectral domain for strongly stretched pulses. In this way a modulation of the temporal phase is turned into a modulation of the spectral phase. All the measurements concerning phases and modulation spectral phase correction are presented in the sixth chapter. In the last chapter we propose an extension of the temporal phase correction by correcting non-linear effects directly in the temporal phase. This correction will improve the performances of the peta-watt laser. Numerical simulations show that the temporal phase correction can lead to a

Posterior lattice degeneration characterized by spectral domain optical coherence tomography.

Science.gov (United States)

Manjunath, Varsha; Taha, Mohammed; Fujimoto, James G; Duker, Jay S

2011-03-01

The purpose of this study was to use high-resolution spectral domain optical coherence tomography in the characterization of retinal and vitreal morphological changes overlying posterior lattice degeneration. A cross-sectional retrospective analysis was performed on 13 eyes of 13 nonconsecutive subjects with posterior lattice degeneration seen at the New England Eye Center, Tufts Medical Center between October 2009 and January 2010. Spectral domain optical coherence tomography images taken through the region of lattice degeneration were qualitatively analyzed. Four characteristic changes of the retina and vitreous were seen in the 13 eyes with lattice degeneration: 1) anterior/posterior U-shaped vitreous traction; 2) retinal breaks; 3) focal retinal thinning; and 4) vitreous membrane formation. The morphologic appearance of vitreous traction and retinal breaks were found to be consistent with previous histologic reports. It is possible to image posterior lattice degeneration in many eyes using spectral domain optical coherence tomography and to visualize the spectrum of retinal and vitreous changes throughout the area of lattice degeneration.

Gamma-Ray Imager With High Spatial And Spectral Resolution

Science.gov (United States)

Callas, John L.; Varnell, Larry S.; Wheaton, William A.; Mahoney, William A.

1996-01-01

Gamma-ray instrument developed to enable both two-dimensional imaging at relatively high spatial resolution and spectroscopy at fractional-photon-energy resolution of about 10 to the negative 3rd power in photon-energy range from 10 keV to greater than 10 MeV. In its spectroscopic aspect, instrument enables identification of both narrow and weak gamma-ray spectral peaks.

Ultrasonic force microscopy: detection and imaging of ultra-thin molecular domains.

Science.gov (United States)

Dinelli, Franco; Albonetti, Cristiano; Kolosov, Oleg V

2011-03-01

The analysis of the formation of ultra-thin organic films is a very important issue. In fact, it is known that the properties of organic light emitting diodes and field effect transistors are strongly affected by the early growth stages. For instance, in the case of sexithiophene, the presence of domains made of molecules with the backbone parallel to the substrate surface has been indirectly evidenced by photoluminescence spectroscopy and confocal microscopy. On the contrary, conventional scanning force microscopy both in contact and intermittent contact modes have failed to detect such domains. In this paper, we show that Ultrasonic Force Microscopy (UFM), sensitive to nanomechanical properties, allows one to directly identify the structure of sub-monolayer thick films. Sexithiophene flat domains have been imaged for the first time with nanometer scale spatial resolution. A comparison with lateral force and intermittent contact modes has been carried out in order to explain the origins of the UFM contrast and its advantages. In particular, it indicates that UFM is highly suitable for investigations where high sensitivity to material properties, low specimen damage and high spatial resolution are required. Copyright © 2010 Elsevier B.V. All rights reserved.

On the use of spectral minutiae in high-resolution palmprint recognition

NARCIS (Netherlands)

Wang, Ruifang; Veldhuis, Raymond N.J.; Ramos, Daniel; Spreeuwers, Lieuwe Jan; Fierrez, Julian; Xu, H.

2013-01-01

The spectral minutiae representation has been proposed as a novel method to minutiae-based fingerprint recognition, which can handle minutiae translation and rotation and improve matching speed. As high-resolution palmprint recognition is also mainly based on minutiae sets, we apply spectral

Posterior Lattice Degeneration Characterized by Spectral Domain Optical Tomography

OpenAIRE

Manjunath, Varsha; Taha, Mohammed; Fujimoto, James G.; Duker, Jay S.

2011-01-01

PURPOSE: To utilize high-resolution spectral domain optical coherence tomography (SD-OCT) in the characterization of retinal and vitreal morphological changes overlying posterior lattice degeneration. METHODS: A cross-sectional, retrospective analysis was performed on 13 eyes of 13 nonconsecutive subjects with posterior lattice degeneration seen at the New England Eye Center, Tufts Medical Center between October 2009 and January 2010. SD-OCT images taken through the region of latti...

Kite aerial photography for low-cost, ultra-high spatial resolution multi-spectral mapping of intertidal landscapes.

Directory of Open Access Journals (Sweden)

Mitch Bryson

Full Text Available Intertidal ecosystems have primarily been studied using field-based sampling; remote sensing offers the ability to collect data over large areas in a snapshot of time that could complement field-based sampling methods by extrapolating them into the wider spatial and temporal context. Conventional remote sensing tools (such as satellite and aircraft imaging provide data at limited spatial and temporal resolutions and relatively high costs for small-scale environmental science and ecologically-focussed studies. In this paper, we describe a low-cost, kite-based imaging system and photogrammetric/mapping procedure that was developed for constructing high-resolution, three-dimensional, multi-spectral terrain models of intertidal rocky shores. The processing procedure uses automatic image feature detection and matching, structure-from-motion and photo-textured terrain surface reconstruction algorithms that require minimal human input and only a small number of ground control points and allow the use of cheap, consumer-grade digital cameras. The resulting maps combine imagery at visible and near-infrared wavelengths and topographic information at sub-centimeter resolutions over an intertidal shoreline 200 m long, thus enabling spatial properties of the intertidal environment to be determined across a hierarchy of spatial scales. Results of the system are presented for an intertidal rocky shore at Jervis Bay, New South Wales, Australia. Potential uses of this technique include mapping of plant (micro- and macro-algae and animal (e.g. gastropods assemblages at multiple spatial and temporal scales.

Kite aerial photography for low-cost, ultra-high spatial resolution multi-spectral mapping of intertidal landscapes.

Science.gov (United States)

Bryson, Mitch; Johnson-Roberson, Matthew; Murphy, Richard J; Bongiorno, Daniel

2013-01-01

Intertidal ecosystems have primarily been studied using field-based sampling; remote sensing offers the ability to collect data over large areas in a snapshot of time that could complement field-based sampling methods by extrapolating them into the wider spatial and temporal context. Conventional remote sensing tools (such as satellite and aircraft imaging) provide data at limited spatial and temporal resolutions and relatively high costs for small-scale environmental science and ecologically-focussed studies. In this paper, we describe a low-cost, kite-based imaging system and photogrammetric/mapping procedure that was developed for constructing high-resolution, three-dimensional, multi-spectral terrain models of intertidal rocky shores. The processing procedure uses automatic image feature detection and matching, structure-from-motion and photo-textured terrain surface reconstruction algorithms that require minimal human input and only a small number of ground control points and allow the use of cheap, consumer-grade digital cameras. The resulting maps combine imagery at visible and near-infrared wavelengths and topographic information at sub-centimeter resolutions over an intertidal shoreline 200 m long, thus enabling spatial properties of the intertidal environment to be determined across a hierarchy of spatial scales. Results of the system are presented for an intertidal rocky shore at Jervis Bay, New South Wales, Australia. Potential uses of this technique include mapping of plant (micro- and macro-algae) and animal (e.g. gastropods) assemblages at multiple spatial and temporal scales.

Analysis of ultra-narrow ferromagnetic domain walls

Energy Technology Data Exchange (ETDEWEB)

Jenkins, Catherine; Paul, David

2012-01-10

New materials with high magnetic anisotropy will have domains separated by ultra-narrow ferromagnetic walls with widths on the order of a few unit cells, approaching the limit where the elastic continuum approximation often used in micromagnetic simulations is accurate. The limits of this approximation are explored, and the static and dynamic interactions with intrinsic crystalline defects and external driving elds are modeled. The results developed here will be important when considering the stability of ultra-high-density storage media.

High-spatial resolution and high-spectral resolution detector for use in the measurement of solar flare hard x rays

International Nuclear Information System (INIS)

Desai, U.D.; Orwig, L.E.

1988-01-01

In the areas of high spatial resolution, the evaluation of a hard X-ray detector with 65 micron spatial resolution for operation in the energy range from 30 to 400 keV is proposed. The basic detector is a thick large-area scintillator faceplate, composed of a matrix of high-density scintillating glass fibers, attached to a proximity type image intensifier tube with a resistive-anode digital readout system. Such a detector, combined with a coded-aperture mask, would be ideal for use as a modest-sized hard X-ray imaging instrument up to X-ray energies as high as several hundred keV. As an integral part of this study it was also proposed that several techniques be critically evaluated for X-ray image coding which could be used with this detector. In the area of high spectral resolution, it is proposed to evaluate two different types of detectors for use as X-ray spectrometers for solar flares: planar silicon detectors and high-purity germanium detectors (HPGe). Instruments utilizing these high-spatial-resolution detectors for hard X-ray imaging measurements from 30 to 400 keV and high-spectral-resolution detectors for measurements over a similar energy range would be ideally suited for making crucial solar flare observations during the upcoming maximum in the solar cycle

Ultra-high resolution flat-panel volume CT: fundamental principles, design architecture, and system characterization

International Nuclear Information System (INIS)

Gupta, Rajiv; Brady, Tom; Grasruck, Michael; Suess, Christoph; Schmidt, Bernhard; Stierstorfer, Karl; Popescu, Stefan; Flohr, Thomas; Bartling, Soenke H.

2006-01-01

Digital flat-panel-based volume CT (VCT) represents a unique design capable of ultra-high spatial resolution, direct volumetric imaging, and dynamic CT scanning. This innovation, when fully developed, has the promise of opening a unique window on human anatomy and physiology. For example, the volumetric coverage offered by this technology enables us to observe the perfusion of an entire organ, such as the brain, liver, or kidney, tomographically (e.g., after a transplant or ischemic event). By virtue of its higher resolution, one can directly visualize the trabecular structure of bone. This paper describes the basic design architecture of VCT. Three key technical challenges, viz., scatter correction, dynamic range extension, and temporal resolution improvement, must be addressed for successful implementation of a VCT scanner. How these issues are solved in a VCT prototype and the modifications necessary to enable ultra-high resolution volumetric scanning are described. The fundamental principles of scatter correction and dose reduction are illustrated with the help of an actual prototype. The image quality metrics of this prototype are characterized and compared with a multi-detector CT (MDCT). (orig.)

Ultra-high resolution flat-panel volume CT: fundamental principles, design architecture, and system characterization

Energy Technology Data Exchange (ETDEWEB)

Gupta, Rajiv; Brady, Tom [Massachusetts General Hospital, Department of Radiology, Founders House, FND-2-216, Boston, MA (United States); Grasruck, Michael; Suess, Christoph; Schmidt, Bernhard; Stierstorfer, Karl; Popescu, Stefan; Flohr, Thomas [Siemens Medical Solutions, Forchheim (Germany); Bartling, Soenke H. [Hannover Medical School, Department of Neuroradiology, Hannover (Germany)

2006-06-15

Digital flat-panel-based volume CT (VCT) represents a unique design capable of ultra-high spatial resolution, direct volumetric imaging, and dynamic CT scanning. This innovation, when fully developed, has the promise of opening a unique window on human anatomy and physiology. For example, the volumetric coverage offered by this technology enables us to observe the perfusion of an entire organ, such as the brain, liver, or kidney, tomographically (e.g., after a transplant or ischemic event). By virtue of its higher resolution, one can directly visualize the trabecular structure of bone. This paper describes the basic design architecture of VCT. Three key technical challenges, viz., scatter correction, dynamic range extension, and temporal resolution improvement, must be addressed for successful implementation of a VCT scanner. How these issues are solved in a VCT prototype and the modifications necessary to enable ultra-high resolution volumetric scanning are described. The fundamental principles of scatter correction and dose reduction are illustrated with the help of an actual prototype. The image quality metrics of this prototype are characterized and compared with a multi-detector CT (MDCT). (orig.)

High Spectral Resolution, High Cadence, Imaging X-ray Microcalorimeters for Solar Physics - Phase 2 Project

Data.gov (United States)

National Aeronautics and Space Administration — Microcalorimeter x-ray instruments are non-dispersive, high spectral resolution, broad-band, high cadence imaging spectrometers. We have been developing these...

High speed, High resolution terahertz spectrometers

International Nuclear Information System (INIS)

Kim, Youngchan; Yee, Dae Su; Yi, Miwoo; Ahn, Jaewook

2008-01-01

A variety of sources and methods have been developed for terahertz spectroscopy during almost two decades. Terahertz time domain spectroscopy (THz TDS)has attracted particular attention as a basic measurement method in the fields of THz science and technology. Recently, asynchronous optical sampling (AOS)THz TDS has been demonstrated, featuring rapid data acquisition and a high spectral resolution. Also, terahertz frequency comb spectroscopy (TFCS)possesses attractive features for high precision terahertz spectroscopy. In this presentation, we report on these two types of terahertz spectrometer. Our high speed, high resolution terahertz spectrometer is demonstrated using two mode locked femtosecond lasers with slightly different repetition frequencies without a mechanical delay stage. The repetition frequencies of the two femtosecond lasers are stabilized by use of two phase locked loops sharing the same reference oscillator. The time resolution of our terahertz spectrometer is measured using the cross correlation method to be 270 fs. AOS THz TDS is presented in Fig. 1, which shows a time domain waveform rapidly acquired on a 10ns time window. The inset shows a zoom into the signal with 100ps time window. The spectrum obtained by the fast Fourier Transformation (FFT)of the time domain waveform has a frequency resolution of 100MHz. The dependence of the signal to noise ratio (SNR)on the measurement time is also investigated

Fast and sensitive analysis of beta blockers by ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry.

Science.gov (United States)

Tomková, Jana; Ondra, Peter; Kocianová, Eva; Václavík, Jan

2017-07-01

This paper presents a method for the determination of acebutolol, betaxolol, bisoprolol, metoprolol, nebivolol and sotalol in human serum by liquid-liquid extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. After liquid-liquid extraction, beta blockers were separated on a reverse-phase analytical column (Acclaim RS 120; 100 × 2.1 mm, 2.2 μm). The total run time was 6 min for each sample. Linearity, limit of detection, limit of quantification, matrix effects, specificity, precision, accuracy, recovery and sample stability were evaluated. The method was successfully applied to the therapeutic drug monitoring of 108 patients with hypertension. This method was also used for determination of beta blockers in 33 intoxicated patients. Copyright © 2016 John Wiley & Sons, Ltd.

Ultra-high resolution optical coherence tomography for encapsulation quality inspection

KAUST Repository

Czajkowski, Jakub

2011-08-28

We present the application of ultra-high resolution optical coherence tomography (UHR-OCT) in evaluation of thin, protective films used in printed electronics. Two types of sample were investigated: microscopy glass and organic field effect transistor (OFET) structure. Samples were coated with thin (1-3 μm) layer of parylene C polymer. Measurements were done using experimental UHR-OCT device based on a Kerr-lens mode locked Ti: sapphire femtosecond laser, photonic crystal fibre and modified, free-space Michelson interferometer. Submicron resolution offered by the UHR-OCT system applied in the study enables registration of both interfaces of the thin encapsulation layer. Complete, volumetric characterisation of protective layers is presented, demonstrating possibility to use OCT for encapsulation quality inspection. © Springer-Verlag 2011.

Ultra-High Resolution Spectroscopic Remote Sensing: A Microscope on Planetary Atmospheres

Science.gov (United States)

Kostiuk, Theodor

2010-01-01

Remote sensing of planetary atmospheres is not complete without studies of all levels of the atmosphere, including the dense cloudy- and haze filled troposphere, relatively clear and important stratosphere and the upper atmosphere, which are the first levels to experience the effects of solar radiation. High-resolution spectroscopy can provide valuable information on these regions of the atmosphere. Ultra-high spectral resolution studies can directly measure atmospheric winds, composition, temperature and non-thermal phenomena, which describe the physics and chemistry of the atmosphere. Spectroscopy in the middle to long infrared wavelengths can also probe levels where dust of haze limit measurements at shorter wavelength or can provide ambiguous results on atmospheric species abundances or winds. A spectroscopic technique in the middle infrared wavelengths analogous to a radio receiver. infrared heterodyne spectroscopy [1], will be describe and used to illustrate the detailed study of atmospheric phenomena not readily possible with other methods. The heterodyne spectral resolution with resolving power greater than 1,000.000 measures the true line shapes of emission and absorption lines in planetary atmospheres. The information on the region of line formation is contained in the line shapes. The absolute frequency of the lines can be measured to I part in 100 ,000,000 and can be used to accurately measure the Doppler frequency shift of the lines, directly measuring the line-of-sight velocity of the gas to --Im/s precision (winds). The technical and analytical methods developed and used to measure and analyze infrared heterodyne measurements will be described. Examples of studies on Titan, Venus, Mars, Earth, and Jupiter will be presented. 'These include atmospheric dynamics on slowly rotating bodies (Titan [2] and Venus [3] and temperature, composition and chemistry on Mars 141, Venus and Earth. The discovery and studies of unique atmospheric phenomena will also be

High spectral resolution infrared observations of V1057 Cygni

International Nuclear Information System (INIS)

Hartmann, L.; Kenyon, S.J.

1987-01-01

High-resolution near-infrared spectra of V1057 Cygni obtained in 1986 with the KPNO 4-m Fourier transform spectrometer provide support for a previously proposed accretion disk model. The model predicts that the observed rotational broadening of spectral lines should be smaller in the infrared than in the optical. The present observations show that V1057 Cyg rotates more slowly at 2.3 microns than at 6000 A by an amount quantitatively consistent with the simple disk models. The absence of any radial velocity variations in either the infrared or optical spectral regions supports the suggestion that the accreted material arises from a remnant disk of protostellar material. 19 references

Ultra-high-resolution alpha spectrometry for nuclear forensics and safeguards applications

International Nuclear Information System (INIS)

Bacrania, Minesh K.; Croce, Mark; Bond, Evelyn; Dry, Donald; Moody, W. Allen; Lamont, Stephen; Rabin, Michael; Rim, Jung; Smith, Audrey; Beall, James; Bennett, Douglas; Kotsubo, Vincent; Horansky, Robert; Hilton, Gene; Schmidt, Daniel; Ullom, Joel; Cantor, Robin

2010-01-01

We will present our work on the development of ultra-high-resolution detectors for alpha particle spectrometry. These detectors, based on superconducting transition-edge sensors, offer energy resolution that is five to ten times better than conventional silicon detectors. Using these microcalorimeter detectors, the isotopic composition of mixed-actinide samples can be determined rapidly without the need for actinide separation chemistry to isolate each element, or mass spectrometry to separate isotopic signatures that can not be resolved using traditional alpha spectrometry (e.g. Pu-239/Pu-240, or Pu-238/Am-241). This paper will cover the detector and measurement system, actinide source preparation, and the quantitative isotopic analysis of a number of forensics- and safeguards-relevant radioactive sources.

Analysis of X-ray Spectra of High-Z Elements obtained on Nike with high spectral and spatial resolution

Science.gov (United States)

Aglitskiy, Yefim; Weaver, J. L.; Karasik, M.; Serlin, V.; Obenschain, S. P.; Ralchenko, Yu.

2014-10-01

The spectra of multi-charged ions of Hf, Ta, W, Pt, Au and Bi have been studied on Nike krypton-fluoride laser facility with the help of two kinds of X-ray spectrometers. First, survey instrument covering a spectral range from 0.5 to 19.5 angstroms which allows simultaneous observation of both M- and N- spectra of above mentioned elements with high spectral resolution. Second, an imaging spectrometer with interchangeable spherically bent Quartz crystals that added higher efficiency, higher spectral resolution and high spatial resolution to the qualities of the former one. Multiple spectral lines with X-ray energies as high as 4 keV that belong to the isoelectronic sequences of Fe, Co, Ni, Cu and Zn were identified with the help of NOMAD package developed by Dr. Yu. Ralchenko and colleagues. In our continuous effort to support DOE-NNSA's inertial fusion program, this campaign covered a wide range of plasma conditions that result in production of relatively energetic X-rays. Work supported by the US DOE/NNSA.

In vivo visualization of photoreceptor layer and lipofuscin accumulation in Stargardt’s disease and fundus flavimaculatus by high resolution spectral-domain optical coherence tomography

Directory of Open Access Journals (Sweden)

Giuseppe Querques

2009-12-01

Full Text Available Giuseppe Querques, Rosy Prato, Gabriel Coscas, Gisèle Soubrane, Eric H SouiedDepartment of Ophthalmology, Hopital Intercommunal de Creteil, University Paris XII, FranceIntroduction: To assess photoreceptor (PR layer morphology in patients with Stargardt’s disease (STGD and fundus flavimaculatus (FFM using high resolution spectral domain optical coherence tomography (HD-OCT; OCT 4000 Cirrus, Humphrey-Zeiss, San Leandro, CA.Methods: This was a prospective observational case series. Sixteen consecutive patients with STGD and FFM underwent a complete ophthalmologic examination. Optical coherence tomography examination was performed with HD-OCT, a high-speed (27,000 axial scans per second OCT system using spectral/Fourier domain detection, with an axial image resolution of 5 µm.Results: A total of 31 eyes were included in the study. Transverse loss of the PR layer in the foveal region was shown by HD-OCT. Twenty eyes with clinically evident central atrophy had a disruption of either the Verhoeff‘s membrane (VM or the layer corresponding to the interface of inner segment (IS and outer segment (OS of PR in the foveal region. Among these eyes, 12/20 eyes had a loss of the PR layer (loss of both VM and IS-OS interface in the foveal region. Eleven eyes (11/31 without clinically evident central atrophy had an intact interface of IS and OS of PR centrally. Moreover, we observed hyperreflective deposits: type 1 lesions located within the retinal pigment epithelium (RPE layer and at the level of the outer segments of PR, and type 2 lesions located at the level of the outer nuclear layer and clearly separated from the RPE layer. Type 1 lesions alone were associated with absence of loss of the PR layer in the foveal region in all eyes; type 2 lesions were always associated with presence of type 1 lesions, and often (8/12 eyes associated with loss of the PR layer within the foveal region. Mean best-corrected visual acuity (BCVA was significantly

Very High Spectral Resolution Imaging Spectroscopy: the Fluorescence Explorer (FLEX) Mission

Science.gov (United States)

Moreno, Jose F.; Goulas, Yves; Huth, Andreas; Middleton, Elizabeth; Miglietta, Franco; Mohammed, Gina; Nedbal, Ladislav; Rascher, Uwe; Verhoef, Wouter; Drusch, Matthias

2016-01-01

The Fluorescence Explorer (FLEX) mission has been recently selected as the 8th Earth Explorer by the European Space Agency (ESA). It will be the first mission specifically designed to measure from space vegetation fluorescence emission, by making use of very high spectral resolution imaging spectroscopy techniques. Vegetation fluorescence is the best proxy to actual vegetation photosynthesis which can be measurable from space, allowing an improved quantification of vegetation carbon assimilation and vegetation stress conditions, thus having key relevance for global mapping of ecosystems dynamics and aspects related with agricultural production and food security. The FLEX mission carries the FLORIS spectrometer, with a spectral resolution in the range of 0.3 nm, and is designed to fly in tandem with Copernicus Sentinel-3, in order to provide all the necessary spectral / angular information to disentangle emitted fluorescence from reflected radiance, and to allow proper interpretation of the observed fluorescence spatial and temporal dynamics.

Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner

OpenAIRE

Kakinuma, Ryutaro; Moriyama, Noriyuki; Muramatsu, Yukio; Gomi, Shiho; Suzuki, Masahiro; Nagasawa, Hirobumi; Kusumoto, Masahiko; Aso, Tomohiko; Muramatsu, Yoshihisa; Tsuchida, Takaaki; Tsuta, Koji; Maeshima, Akiko Miyagi; Tochigi, Naobumi; Watanabe, Shun-ichi; Sugihara, Naoki

2015-01-01

Purpose: The image noise and image quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated and compared with those of conventional high-resolution CT (C-HRCT) scanners. Materials and Methods: This study was approved by the institutional review board. A U-HRCT scanner prototype with 0.25 mm × 4 rows and operating at 120 mAs was used. The C-HRCT images were obtained using a 0.5 mm × 16 or 0.5 mm × 64 detector-row CT scanner operating at 150 mAs. Images fr...

Pristine Survey : High-Resolution Spectral Analyses of New Metal-poor Stars

Science.gov (United States)

Venn, Kim; Starkenburg, Else; Martin, Nicolas; Kielty, Collin; Youakim, Kris; Arnetsen, Anke

2018-06-01

The Pristine survey (Starkenburg et al. 2017) is a new and very successful metal-poor star survey. Combining high-quality narrow-band CaHK CFHT/MegaCam photometry with existing broadband photometry from SDSS, then very metal-poor stars have been found as confirmed from low-resolution spectroscopy (Youakim et al. 2017). Furthermore, we have extended this survey towards the Galactic bulge in a pilot program to test the capabilities in the highly crowded and (inhomogeneously) extincted bulge (Arentsen et al. 2018). High resolution spectral follow-up analyses have been initiated at the CFHT with Espadons (Vevolution or changes in the IMF, e.g., carbon enrichment, high [alpha/Fe] ratios vs alpha-challenged stars, and details in the neutron capture element ratios. While these early studies are being carried out using classical model atmospheres and synthetic spectral fitting (Venn et al. 2017, 2018), we are also exploring the use of a neural network for the fast, efficient, and precise determination of these stellar parameters and chemical abundances (e.g., StarNet, Fabbro et al. 2018).

USING A MICRO-UAV FOR ULTRA-HIGH RESOLUTION MULTI-SENSOR OBSERVATIONS OF ANTARCTIC MOSS BEDS

Directory of Open Access Journals (Sweden)

A. Lucieer

2012-07-01

Full Text Available This study is the first to use an Unmanned Aerial Vehicle (UAV for mapping moss beds in Antarctica. Mosses can be used as indicators for the regional effects of climate change. Mapping and monitoring their extent and health is therefore important. UAV aerial photography provides ultra-high resolution spatial data for this purpose. We developed a technique to extract an extremely dense 3D point cloud from overlapping UAV aerial photography based on structure from motion (SfM algorithms. The combination of SfM and patch-based multi-view stereo image vision algorithms resulted in a 2 cm resolution digital terrain model (DTM. This detailed topographic information combined with vegetation indices derived from a 6-band multispectral sensor enabled the assessment of moss bed health. This novel UAV system has allowed us to map different environmental characteristics of the moss beds at ultra-high resolution providing us with a better understanding of these fragile Antarctic ecosystems. The paper provides details on the different UAV instruments and the image processing framework resulting in DEMs, vegetation indices, and terrain derivatives.

Influence of spectral resolution, spectral range and signal-to-noise ratio of Fourier transform infra-red spectra on identification of high explosive substances

Science.gov (United States)

Banas, Krzysztof; Banas, Agnieszka M.; Heussler, Sascha P.; Breese, Mark B. H.

2018-01-01

In the contemporary spectroscopy there is a trend to record spectra with the highest possible spectral resolution. This is clearly justified if the spectral features in the spectrum are very narrow (for example infra-red spectra of gas samples). However there is a plethora of samples (in the liquid and especially in the solid form) where there is a natural spectral peak broadening due to collisions and proximity predominately. Additionally there is a number of portable devices (spectrometers) with inherently restricted spectral resolution, spectral range or both, which are extremely useful in some field applications (archaeology, agriculture, food industry, cultural heritage, forensic science). In this paper the investigation of the influence of spectral resolution, spectral range and signal-to-noise ratio on the identification of high explosive substances by applying multivariate statistical methods on the Fourier transform infra-red spectral data sets is studied. All mathematical procedures on spectral data for dimension reduction, clustering and validation were implemented within R open source environment.

Online monitoring of printed electronics by Spectral-Domain Optical Coherence Tomography

KAUST Repository

Alarousu, Erkki; Alsaggaf, Ahmed; Jabbour, Ghassan E.

2013-01-01

Spectral-Domain Optical Coherence Tomography (SD-OCT) is an optical method capable of 3D imaging of object's internal structure with micron-scale resolution. Modern SD-OCT tools offer the speed capable of online monitoring of printed devices

High Spatial Resolution Visual Band Imagery Outperforms Medium Resolution Spectral Imagery for Ecosystem Assessment in the Semi-Arid Brazilian Sertão

Directory of Open Access Journals (Sweden)

Ran Goldblatt

2017-12-01

Full Text Available Semi-arid ecosystems play a key role in global agricultural production, seasonal carbon cycle dynamics, and longer-run climate change. Because semi-arid landscapes are heterogeneous and often sparsely vegetated, repeated and large-scale ecosystem assessments of these regions have to date been impossible. Here, we assess the potential of high-spatial resolution visible band imagery for semi-arid ecosystem mapping. We use WorldView satellite imagery at 0.3–0.5 m resolution to develop a reference data set of nearly 10,000 labeled examples of three classes—trees, shrubs/grasses, and bare land—across 1000 km 2 of the semi-arid Sertão region of northeast Brazil. Using Google Earth Engine, we show that classification with low-spectral but high-spatial resolution input (WorldView outperforms classification with the full spectral information available from Landsat 30 m resolution imagery as input. Classification with high spatial resolution input improves detection of sparse vegetation and distinction between trees and seasonal shrubs and grasses, two features which are lost at coarser spatial (but higher spectral resolution input. Our total tree cover estimates for the study area disagree with recent estimates using other methods that may underestimate treecover because they confuse trees with seasonal vegetation (shrubs and grasses. This distinction is important for monitoring seasonal and long-run carbon cycle and ecosystem health. Our results suggest that newer remote sensing products that promise high frequency global coverage at high spatial but lower spectral resolution may offer new possibilities for direct monitoring of the world’s semi-arid ecosystems, and we provide methods that could be scaled to do so.

Ultra high resolution imaging of the human head at 8 tesla: 2K x 2K for Y2K.

Science.gov (United States)

Robitaille, P M; Abduljalil, A M; Kangarlu, A

2000-01-01

To acquire ultra high resolution MRI images of the human brain at 8 Tesla within a clinically acceptable time frame. Gradient echo images were acquired from the human head of normal subjects using a transverse electromagnetic resonator operating in quadrature and tuned to 340 MHz. In each study, a group of six images was obtained containing a total of 208 MB of unprocessed information. Typical acquisition parameters were as follows: matrix = 2,000 x 2,000, field of view = 20 cm, slice thickness = 2 mm, number of excitations (NEX) = 1, flip angle = 45 degrees, TR = 750 ms, TE = 17 ms, receiver bandwidth = 69.4 kHz. This resulted in a total scan time of 23 minutes, an in-plane resolution of 100 microm, and a pixel volume of 0.02 mm3. The ultra high resolution images acquired in this study represent more than a 50-fold increase in in-plane resolution relative to conventional 256 x 256 images obtained with a 20 cm field of view and a 5 mm slice thickness. Nonetheless, the ultra high resolution images could be acquired both with adequate image quality and signal to noise. They revealed numerous small venous structures throughout the image plane and provided reasonable delineation between gray and white matter. The elevated signal-to-noise ratio observed in ultra high field magnetic resonance imaging can be utilized to acquire images with a level of resolution approaching the histological level under in vivo conditions. However, brain motion is likely to degrade the useful resolution. This situation may be remedied in part with cardiac gating. Nonetheless, these images represent a significant advance in our ability to examine small anatomical features with noninvasive imaging methods.

High Frequency High Spectral Resolution Focal Plane Arrays for AtLAST

Science.gov (United States)

Baryshev, Andrey

2018-01-01

Large collecting area single dish telescope such as ATLAST will be especially effective for medium (R 1000) and high (R 50000) spectral resolution observations. Large focal plane array is a natural solution to increase mapping speed. For medium resolution direct detectors with filter banks (KIDs) and or heterodyne technology can be employed. We will analyze performance limits of comparable KID and SIS focal plane array taking into account quantum limit and high background condition of terrestrial observing site. For large heterodyne focal plane arrays, a high current density AlN junctions open possibility of large instantaneous bandwidth >40%. This and possible multi frequency band FPSs presents a practical challenge for spatial sampling and scanning strategies. We will discuss phase array feeds as a possible solution, including a modular back-end system, which can be shared between KID and SIS based FPA. Finally we will discuss achievable sensitivities and pixel co unts for a high frequency (>500 GHz) FPAs and address main technical challenges: LO distribution, wire counts, bias line multiplexing, and monolithic vs. discrete mixer component integration.

A method of incident angle estimation for high resolution spectral recovery in filter-array-based spectrometers

Science.gov (United States)

Kim, Cheolsun; Lee, Woong-Bi; Ju, Gun Wu; Cho, Jeonghoon; Kim, Seongmin; Oh, Jinkyung; Lim, Dongsung; Lee, Yong Tak; Lee, Heung-No

2017-02-01

In recent years, there has been an increasing interest in miniature spectrometers for research and development. Especially, filter-array-based spectrometers have advantages of low cost and portability, and can be applied in various fields such as biology, chemistry and food industry. Miniaturization in optical filters causes degradation of spectral resolution due to limitations on spectral responses and the number of filters. Nowadays, many studies have been reported that the filter-array-based spectrometers have achieved resolution improvements by using digital signal processing (DSP) techniques. The performance of the DSP-based spectral recovery highly depends on the prior information of transmission functions (TFs) of the filters. The TFs vary with respect to an incident angle of light onto the filter-array. Conventionally, it is assumed that the incident angle of light on the filters is fixed and the TFs are known to the DSP. However, the incident angle is inconstant according to various environments and applications, and thus TFs also vary, which leads to performance degradation of spectral recovery. In this paper, we propose a method of incident angle estimation (IAE) for high resolution spectral recovery in the filter-array-based spectrometers. By exploiting sparse signal reconstruction of the L1- norm minimization, IAE estimates an incident angle among all possible incident angles which minimizes the error of the reconstructed signal. Based on IAE, DSP effectively provides a high resolution spectral recovery in the filter-array-based spectrometers.

Classification of Ultra-High Resolution Orthophotos Combined with DSM Using a Dual Morphological Top Hat Profile

Directory of Open Access Journals (Sweden)

Qian Zhang

2015-12-01

Full Text Available New aerial sensors and platforms (e.g., unmanned aerial vehicles (UAVs are capable of providing ultra-high resolution remote sensing data (less than a 30-cm ground sampling distance (GSD. This type of data is an important source for interpreting sub-building level objects; however, it has not yet been explored. The large-scale differences of urban objects, the high spectral variability and the large perspective effect bring difficulties to the design of descriptive features. Therefore, features representing the spatial information of the objects are essential for dealing with the spectral ambiguity. In this paper, we proposed a dual morphology top-hat profile (DMTHP using both morphology reconstruction and erosion with different granularities. Due to the high dimensional feature space, we have proposed an adaptive scale selection procedure to reduce the feature dimension according to the training samples. The DMTHP is extracted from both images and Digital Surface Models (DSM to obtain complimentary information. The random forest classifier is used to classify the features hierarchically. Quantitative experimental results on aerial images with 9-cm and UAV images with 5-cm GSD are performed. Under our experiments, improvements of 10% and 2% in overall accuracy are obtained in comparison with the well-known differential morphological profile (DMP feature, and superior performance is observed over other tested features. Large format data with 20,000 × 20,000 pixels are used to perform a qualitative experiment using the proposed method, which shows its promising potential. The experiments also demonstrate that the DSM information has greatly enhanced the classification accuracy. In the best case in our experiment, it gives rise to a classification accuracy from 63.93% (spectral information only to 94.48% (the proposed method.

A postprocessing method based on high-resolution spectral estimation for FDTD calculation of phononic band structures

Energy Technology Data Exchange (ETDEWEB)

Su Xiaoxing, E-mail: xxsu@bjtu.edu.c [School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing 100044 (China); Li Jianbao; Wang Yuesheng [Institute of Engineering Mechanics, Beijing Jiaotong University, Beijing 100044 (China)

2010-05-15

If the energy bands of a phononic crystal are calculated by the finite difference time domain (FDTD) method combined with the fast Fourier transform (FFT), good estimation of the eigenfrequencies can only be ensured by the postprocessing of sufficiently long time series generated by a large number of FDTD iterations. In this paper, a postprocessing method based on the high-resolution spectral estimation via the Yule-Walker method is proposed to overcome this difficulty. Numerical simulation results for three-dimensional acoustic and two-dimensional elastic systems show that, compared with the classic FFT-based postprocessing method, the proposed method can give much better estimation of the eigenfrequencies when the FDTD is run with relatively few iterations.

A postprocessing method based on high-resolution spectral estimation for FDTD calculation of phononic band structures

International Nuclear Information System (INIS)

Su Xiaoxing; Li Jianbao; Wang Yuesheng

2010-01-01

If the energy bands of a phononic crystal are calculated by the finite difference time domain (FDTD) method combined with the fast Fourier transform (FFT), good estimation of the eigenfrequencies can only be ensured by the postprocessing of sufficiently long time series generated by a large number of FDTD iterations. In this paper, a postprocessing method based on the high-resolution spectral estimation via the Yule-Walker method is proposed to overcome this difficulty. Numerical simulation results for three-dimensional acoustic and two-dimensional elastic systems show that, compared with the classic FFT-based postprocessing method, the proposed method can give much better estimation of the eigenfrequencies when the FDTD is run with relatively few iterations.

High-resolution NMR structures of the domains of Saccharomyces cerevisiae Tho1

International Nuclear Information System (INIS)

Jacobsen, Julian O. B.; Allen, Mark D.; Freund, Stefan M. V.; Bycroft, Mark

2016-01-01

In this study, high-resolution structures of both the N-terminal DNA-binding SAP domain and the C-terminal RNA-binding domain of S. cerevisiae Tho1 have been determined. THO is a multi-protein complex involved in the formation of messenger ribonuclear particles (mRNPs) by coupling transcription with mRNA processing and export. THO is thought to be formed from five subunits, Tho2p, Hpr1p, Tex1p, Mft1p and Thp2p, and recent work has determined a low-resolution structure of the complex [Poulsen et al. (2014 ▸), PLoS One, 9, e103470]. A number of additional proteins are thought to be involved in the formation of mRNP in yeast, including Tho1, which has been shown to bind RNA in vitro and is recruited to actively transcribed chromatin in vivo in a THO-complex and RNA-dependent manner. Tho1 is known to contain a SAP domain at the N-terminus, but the ability to suppress the expression defects of the hpr1Δ mutant of THO was shown to reside in the RNA-binding C-terminal region. In this study, high-resolution structures of both the N-terminal DNA-binding SAP domain and C-terminal RNA-binding domain have been determined

High-resolution NMR structures of the domains of Saccharomyces cerevisiae Tho1

Energy Technology Data Exchange (ETDEWEB)

Jacobsen, Julian O. B.; Allen, Mark D.; Freund, Stefan M. V.; Bycroft, Mark, E-mail: mxb@mrc-lmb.cam.ac.uk [MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH (United Kingdom)

2016-05-23

In this study, high-resolution structures of both the N-terminal DNA-binding SAP domain and the C-terminal RNA-binding domain of S. cerevisiae Tho1 have been determined. THO is a multi-protein complex involved in the formation of messenger ribonuclear particles (mRNPs) by coupling transcription with mRNA processing and export. THO is thought to be formed from five subunits, Tho2p, Hpr1p, Tex1p, Mft1p and Thp2p, and recent work has determined a low-resolution structure of the complex [Poulsen et al. (2014 ▸), PLoS One, 9, e103470]. A number of additional proteins are thought to be involved in the formation of mRNP in yeast, including Tho1, which has been shown to bind RNA in vitro and is recruited to actively transcribed chromatin in vivo in a THO-complex and RNA-dependent manner. Tho1 is known to contain a SAP domain at the N-terminus, but the ability to suppress the expression defects of the hpr1Δ mutant of THO was shown to reside in the RNA-binding C-terminal region. In this study, high-resolution structures of both the N-terminal DNA-binding SAP domain and C-terminal RNA-binding domain have been determined.

Development of a high spectral resolution surface albedo product for the ARM Southern Great Plains Central Facility

Energy Technology Data Exchange (ETDEWEB)

McFarlane, Sally A.; Gaustad, Krista L.; Mlawer, Eli J.; Long, Charles N.; Delamere, Jennifer

2011-09-01

We present a method for identifying dominant surface type and estimating high spectral resolution surface albedo at the Atmospheric Radiation Measurement (ARM) facility at the Southern Great Plains (SGP) site in Oklahoma for use in radiative transfer calculations. Given a set of 6-channel narrowband visible and near-infrared irradiance measurements from upward and downward looking multi-filter radiometers (MFRs), four different surface types (snow-covered, green vegetation, partial vegetation, non-vegetated) can be identified. A normalized difference vegetation index (NDVI) is used to distinguish between vegetated and non-vegetated surfaces, and a scaled NDVI index is used to estimate the percentage of green vegetation in partially vegetated surfaces. Based on libraries of spectral albedo measurements, a piecewise continuous function is developed to estimate the high spectral resolution surface albedo for each surface type given the MFR albedo values as input. For partially vegetated surfaces, the albedo is estimated as a linear combination of the green vegetation and non-vegetated surface albedo values. The estimated albedo values are evaluated through comparison to high spectral resolution albedo measurements taken during several Intensive Observational Periods (IOPs) and through comparison of the integrated spectral albedo values to observed broadband albedo measurements. The estimated spectral albedo values agree well with observations for the visible wavelengths constrained by the MFR measurements, but have larger biases and variability at longer wavelengths. Additional MFR channels at 1100 nm and/or 1600 nm would help constrain the high resolution spectral albedo in the near infrared region.

Development of a high spectral resolution surface albedo product for the ARM Southern Great Plains central facility

Science.gov (United States)

McFarlane, S. A.; Gaustad, K. L.; Mlawer, E. J.; Long, C. N.; Delamere, J.

2011-09-01

We present a method for identifying dominant surface type and estimating high spectral resolution surface albedo at the Atmospheric Radiation Measurement (ARM) facility at the Southern Great Plains (SGP) site in Oklahoma for use in radiative transfer calculations. Given a set of 6-channel narrowband visible and near-infrared irradiance measurements from upward and downward looking multi-filter radiometers (MFRs), four different surface types (snow-covered, green vegetation, partial vegetation, non-vegetated) can be identified. A normalized difference vegetation index (NDVI) is used to distinguish between vegetated and non-vegetated surfaces, and a scaled NDVI index is used to estimate the percentage of green vegetation in partially vegetated surfaces. Based on libraries of spectral albedo measurements, a piecewise continuous function is developed to estimate the high spectral resolution surface albedo for each surface type given the MFR albedo values as input. For partially vegetated surfaces, the albedo is estimated as a linear combination of the green vegetation and non-vegetated surface albedo values. The estimated albedo values are evaluated through comparison to high spectral resolution albedo measurements taken during several Intensive Observational Periods (IOPs) and through comparison of the integrated spectral albedo values to observed broadband albedo measurements. The estimated spectral albedo values agree well with observations for the visible wavelengths constrained by the MFR measurements, but have larger biases and variability at longer wavelengths. Additional MFR channels at 1100 nm and/or 1600 nm would help constrain the high resolution spectral albedo in the near infrared region.

Development of a high spectral resolution surface albedo product for the ARM Southern Great Plains central facility

Directory of Open Access Journals (Sweden)

J. Delamere

2011-09-01

Full Text Available We present a method for identifying dominant surface type and estimating high spectral resolution surface albedo at the Atmospheric Radiation Measurement (ARM facility at the Southern Great Plains (SGP site in Oklahoma for use in radiative transfer calculations. Given a set of 6-channel narrowband visible and near-infrared irradiance measurements from upward and downward looking multi-filter radiometers (MFRs, four different surface types (snow-covered, green vegetation, partial vegetation, non-vegetated can be identified. A normalized difference vegetation index (NDVI is used to distinguish between vegetated and non-vegetated surfaces, and a scaled NDVI index is used to estimate the percentage of green vegetation in partially vegetated surfaces. Based on libraries of spectral albedo measurements, a piecewise continuous function is developed to estimate the high spectral resolution surface albedo for each surface type given the MFR albedo values as input. For partially vegetated surfaces, the albedo is estimated as a linear combination of the green vegetation and non-vegetated surface albedo values. The estimated albedo values are evaluated through comparison to high spectral resolution albedo measurements taken during several Intensive Observational Periods (IOPs and through comparison of the integrated spectral albedo values to observed broadband albedo measurements. The estimated spectral albedo values agree well with observations for the visible wavelengths constrained by the MFR measurements, but have larger biases and variability at longer wavelengths. Additional MFR channels at 1100 nm and/or 1600 nm would help constrain the high resolution spectral albedo in the near infrared region.

ANALYZING SPECTRAL CHARACTERISTICS OF SHADOW AREA FROM ADS-40 HIGH RADIOMETRIC RESOLUTION AERIAL IMAGES

Directory of Open Access Journals (Sweden)

Y.-T. Hsieh

2016-06-01

Full Text Available The shadows in optical remote sensing images are regarded as image nuisances in numerous applications. The classification and interpretation of shadow area in a remote sensing image are a challenge, because of the reduction or total loss of spectral information in those areas. In recent years, airborne multispectral aerial image devices have been developed 12-bit or higher radiometric resolution data, including Leica ADS-40, Intergraph DMC. The increased radiometric resolution of digital imagery provides more radiometric details of potential use in classification or interpretation of land cover of shadow areas. Therefore, the objectives of this study are to analyze the spectral properties of the land cover in the shadow areas by ADS-40 high radiometric resolution aerial images, and to investigate the spectral and vegetation index differences between the various shadow and non-shadow land covers. According to research findings of spectral analysis of ADS-40 image: (i The DN values in shadow area are much lower than in nonshadow area; (ii DN values received from shadowed areas that will also be affected by different land cover, and it shows the possibility of land cover property retrieval as in nonshadow area; (iii The DN values received from shadowed regions decrease in the visible band from short to long wavelengths due to scattering; (iv The shadow area NIR of vegetation category also shows a strong reflection; (v Generally, vegetation indexes (NDVI still have utility to classify the vegetation and non-vegetation in shadow area. The spectral data of high radiometric resolution images (ADS-40 is potential for the extract land cover information of shadow areas.

Impacts of spectral nudging on the simulated surface air temperature in summer compared with the selection of shortwave radiation and land surface model physics parameterization in a high-resolution regional atmospheric model

Science.gov (United States)

Park, Jun; Hwang, Seung-On

2017-11-01

The impact of a spectral nudging technique for the dynamical downscaling of the summer surface air temperature in a high-resolution regional atmospheric model is assessed. The performance of this technique is measured by comparing 16 analysis-driven simulation sets of physical parameterization combinations of two shortwave radiation and four land surface model schemes of the model, which are known to be crucial for the simulation of the surface air temperature. It is found that the application of spectral nudging to the outermost domain has a greater impact on the regional climate than any combination of shortwave radiation and land surface model physics schemes. The optimal choice of two model physics parameterizations is helpful for obtaining more realistic spatiotemporal distributions of land surface variables such as the surface air temperature, precipitation, and surface fluxes. However, employing spectral nudging adds more value to the results; the improvement is greater than using sophisticated shortwave radiation and land surface model physical parameterizations. This result indicates that spectral nudging applied to the outermost domain provides a more accurate lateral boundary condition to the innermost domain when forced by analysis data by securing the consistency with large-scale forcing over a regional domain. This consequently indirectly helps two physical parameterizations to produce small-scale features closer to the observed values, leading to a better representation of the surface air temperature in a high-resolution downscaled climate.

Quality of Experience for Large Ultra-High-Resolution Tiled Displays with Synchronization Mismatch

Directory of Open Access Journals (Sweden)

Deshpande Sachin

2011-01-01

Full Text Available This paper relates to quality of experience when viewing images, video, or other content on large ultra-high-resolution displays made from individual display tiles. We define experiments to measure vernier acuity caused by synchronization mismatch for moving images. The experiments are used to obtain synchronization mismatch acuity threshold as a function of object velocity and as a function of occlusion or gap width. Our main motivation for measuring the synchronization mismatch vernier acuity is its relevance in the application of tiled display systems, which create a single contiguous image using individual discrete panels arranged in a matrix with each panel utilizing a distributed synchronization algorithm to display parts of the overall image. We also propose a subjective assessment method for perception evaluation of synchronization mismatch for large ultra-high-resolution tiled displays. For this, we design a synchronization mismatch measurement test video set for various tile configurations for various interpanel synchronization mismatch values. The proposed method for synchronization mismatch perception can evaluate tiled displays with or without tile bezels. The results from this work can help during design of low-cost tiled display systems, which utilize distributed synchronization mechanisms for a contiguous or bezeled image display.

Automated road network extraction from high spatial resolution multi-spectral imagery

Science.gov (United States)

Zhang, Qiaoping

For the last three decades, the Geomatics Engineering and Computer Science communities have considered automated road network extraction from remotely-sensed imagery to be a challenging and important research topic. The main objective of this research is to investigate the theory and methodology of automated feature extraction for image-based road database creation, refinement or updating, and to develop a series of algorithms for road network extraction from high resolution multi-spectral imagery. The proposed framework for road network extraction from multi-spectral imagery begins with an image segmentation using the k-means algorithm. This step mainly concerns the exploitation of the spectral information for feature extraction. The road cluster is automatically identified using a fuzzy classifier based on a set of predefined road surface membership functions. These membership functions are established based on the general spectral signature of road pavement materials and the corresponding normalized digital numbers on each multi-spectral band. Shape descriptors of the Angular Texture Signature are defined and used to reduce the misclassifications between roads and other spectrally similar objects (e.g., crop fields, parking lots, and buildings). An iterative and localized Radon transform is developed for the extraction of road centerlines from the classified images. The purpose of the transform is to accurately and completely detect the road centerlines. It is able to find short, long, and even curvilinear lines. The input image is partitioned into a set of subset images called road component images. An iterative Radon transform is locally applied to each road component image. At each iteration, road centerline segments are detected based on an accurate estimation of the line parameters and line widths. Three localization approaches are implemented and compared using qualitative and quantitative methods. Finally, the road centerline segments are grouped into a

High spectral resolution studies of gamma ray bursts on new missions

International Nuclear Information System (INIS)

Desai, U. D.; Acuna, M. H.; Cline, T. L.; Dennis, B. R.; Orwig, L. E.; Trombka, J. I.; Starr, R. D.

1996-01-01

Two new missions will be launched in 1996 and 1997, each carrying X-ray and gamma ray detectors capable of high spectral resolution at room temperature. The Argentine Satelite de Aplicaciones Cientificas (SAC-B) and the Small Spacecraft Technology Initiative (SSTI) Clark missions will each carry several arrays of X-ray detectors primarily intended for the study of solar flares and gamma-ray bursts. Arrays of small (1 cm 2 ) cadmium zinc telluride (CZT) units will provide x-ray measurements in the 10 to 80 keV range with an energy resolution of ≅6 keV. Arrays of both silicon avalanche photodiodes (APD) and P-intrinsic-N (PIN) photodiodes (for the SAC-B mission only) will provide energy coverage from 2-25 keV with ≅1 keV resolution. For SAC-B, higher energy spectral data covering the 30-300 keV energy range will be provided by CsI(Tl) scintillators coupled to silicon APDs, resulting in similar resolution but greater simplicity relative to conventional CsI/PMT systems. Because of problems with the Pegasus launch vehicle, the launch of SAC-B has been delayed until 1997. The launch of the SSTI Clark mission is scheduled for June 1996

Wide-field Spatio-Spectral Interferometry: Bringing High Resolution to the Far- Infrared

Science.gov (United States)

Leisawitx, David

Wide-field spatio-spectral interferometry combines spatial and spectral interferometric data to provide integral field spectroscopic information over a wide field of view. This technology breaks through a mission cost barrier that stands in the way of resolving spatially and measuring spectroscopically at far-infrared wavelengths objects that will lead to a deep understanding of planetary system and galaxy formation processes. A space-based far-IR interferometer will combine Spitzer s superb sensitivity with a two order of magnitude gain in angular resolution, and with spectral resolution in the thousands. With the possible exception of detector technology, which is advancing with support from other research programs, the greatest challenge for far-IR interferometry is to demonstrate that the interferometer will actually produce the images and spectra needed to satisfy mission science requirements. With past APRA support, our team has already developed the highly specialized hardware testbed, image projector, computational model, and image construction software required for the proposed effort, and we have access to an ideal test facility.

High-resolution retinal imaging using adaptive optics and Fourier-domain optical coherence tomography

Science.gov (United States)

Olivier, Scot S.; Werner, John S.; Zawadzki, Robert J.; Laut, Sophie P.; Jones, Steven M.

2010-09-07

This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4.times.4.times.6 .mu.m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

Time-Domain Diversity in Ultra-Wideband MIMO Communications

Directory of Open Access Journals (Sweden)

Alain Sibille

2005-03-01

Full Text Available The development of ultra-wideband (UWB communications is impeded by the drastic transmitted power limitations imposed by regulation authorities due to the “polluting” character of these radio emissions with respect to existing services. Technical solutions must be researched in order either to limit the level of spectral pollution by UWB devices or to increase their reception sensitivity. In the present work, we consider pulse-based modulations and investigate time-domain multiple-input multiple-output (MIMO diversity as one such possible solution. The basic principles of time-domain diversity in the extreme (low multipath density or intermediate (dense multipath UWB regimes are addressed, which predict the possibility of a MIMO gain equal to the product Nt×Nr of the numbers of transmit/receive antenna elements when the channel is not too severe. This analysis is confirmed by simulations using a parametric empirical stochastic double-directional channel model. They confirm the potential interest of MIMO approaches solutions in order to bring a valuable performance gain in UWB communications.

High resolution NMR spectroscopy of nanocrystalline proteins at ultra-high magnetic field

International Nuclear Information System (INIS)

Sperling, Lindsay J.; Nieuwkoop, Andrew J.; Lipton, Andrew S.; Berthold, Deborah A.; Rienstra, Chad M.

2010-01-01

Magic-angle spinning (MAS) solid-state NMR (SSNMR) spectroscopy of uniformly- 13 C, 15 N labeled protein samples provides insight into atomic-resolution chemistry and structure. Data collection efficiency has advanced remarkably in the last decade; however, the study of larger proteins is still challenged by relatively low resolution in comparison to solution NMR. In this study, we present a systematic analysis of SSNMR protein spectra acquired at 11.7, 17.6 and 21.1 Tesla ( 1 H frequencies of 500, 750, and 900 MHz). For two protein systems-GB1, a 6 kDa nanocrystalline protein and DsbA, a 21 kDa nanocrystalline protein-line narrowing is demonstrated in all spectral regions with increasing field. Resolution enhancement is greatest in the aliphatic region, including methine, methylene and methyl sites. The resolution for GB1 increases markedly as a function of field, and for DsbA, resolution in the C-C region increases by 42%, according to the number of peaks that can be uniquely picked and integrated in the 900 MHz spectra when compared to the 500 MHz spectra. Additionally, chemical exchange is uniquely observed in the highest field spectra for at least two isoleucine Cδ1 sites in DsbA. These results further illustrate the benefits of high-field MAS SSNMR spectroscopy for protein structural studies.

A Concept of Multi-Mode High Spectral Resolution Lidar Using Mach-Zehnder Interferometer

Directory of Open Access Journals (Sweden)

Jin Yoshitaka

2016-01-01

Full Text Available In this paper, we present the design of a High Spectral Resolution Lidar (HSRL using a laser that oscillates in a multi-longitudinal mode. Rayleigh and Mie scattering components are separated using a Mach-Zehnder Interferometer (MZI with the same free spectral range (FSR as the transmitted laser. The transmitted laser light is measured as a reference signal with the same MZI. By scanning the MZI periodically with a scanning range equal to the mode spacing, we can identify the maximum Mie and the maximum Rayleigh signals using the reference signal. The cross talk due to the spectral width of each laser mode can also be estimated.

Pulse shaping for high data rate ultra-wideband wireless transmission under the Russian spectral emission mask

DEFF Research Database (Denmark)

Rommel, Simon; Grakhova, Elizaveta P.; Jurado-Navas, Antonio

2017-01-01

This paper addresses impulse-radio ultra-wideband (IR-UWB) transmission under the Russian spectral emission mask for unlicensed UWB radio communications. Four pulse shapes are proposed and their bit error rate (BER) performance is both estimated analytically and evaluated experimentally. Well......-known shapes such as the Gaussian, root-raised cosine, hyperbolic secant, and the frequency B-spline wavelet are used to form linear combinations of component pulses, shaped to make efficient use of the spectral emission mask. Analytical BER values are derived using a Nakagami-m model, and good agreement......-UWB transmission under the strict regulations of the Russian spectral emission mask....

Cochlear implant users' spectral ripple resolution.

Science.gov (United States)

Jeon, Eun Kyung; Turner, Christopher W; Karsten, Sue A; Henry, Belinda A; Gantz, Bruce J

2015-10-01

This study revisits the issue of the spectral ripple resolution abilities of cochlear implant (CI) users. The spectral ripple resolution of recently implanted CI recipients (implanted during the last 10 years) were compared to those of CI recipients implanted 15 to 20 years ago, as well as those of normal-hearing and hearing-impaired listeners from previously published data from Henry, Turner, and Behrens [J. Acoust. Soc. Am. 118, 1111-1121 (2005)]. More recently, implanted CI recipients showed significantly better spectral ripple resolution. There is no significant difference in spectral ripple resolution for these recently implanted subjects compared to hearing-impaired (acoustic) listeners. The more recently implanted CI users had significantly better pre-operative speech perception than previously reported CI users. These better pre-operative speech perception scores in CI users from the current study may be related to better performance on the spectral ripple discrimination task; however, other possible factors such as improvements in internal and external devices cannot be excluded.

Report on Ultra-high Resolution Gamma-/X-ray Analysis of Uranium Skull Oxide

International Nuclear Information System (INIS)

Friedrich, S.; Velazquez, M.; Drury, O.; Salaymeh, S.

2009-01-01

We have utilized the high energy resolution and high peak-to-background ratio of superconducting TES γ-detectors at very low energies for non-destructive analysis of a skull oxide derived from reprocessed nuclear fuel. Specifically, we demonstrate that superconducting detectors can separate and analyze the strong actinide emission lines in the spectral region below 60 keV that are often obscured in γ-measurements with conventional Ge detectors.

The new high-resolution IRMS MAT253 ULTRA at Utrecht University

Science.gov (United States)

Röckmann, Thomas; Hofmann, Magdalena; Paul, Dipayan; Popa, Elena; Adnew, Getachew

2017-04-01

In 2016, the new high-resolution, multi-collector isotope ratio mass spectrometer MAT253 ULTRA [1] was installed at Utrecht University. This instrument is designed to reach a mass resolving power of 20,000 to 40,000 (M/ΔM). The ion currents are detected with a variable multi-collector unit that allows to register up to 9 ion currents simultaneously with Faraday cups and ion counters. The width of the entrance slit can be varied between 5 and 250μm so that the instrument can be operated under low, medium and high mass resolution, and an optimum balance between resolution and sensitivity can be selected for the respective applications. The central field of application of the new IRMS at Utrecht University is the measurement of multiply substituted isotopologues (clumped isotopes) in atmospheric trace compounds (e.g. 13CDH3, 13C18O16O, 18O18O, 15N14N18O) [1-7]. It is known from thermodynamics that the zero point energy of a chemical bond usually decreases when multiple heavy isotopes clump together in a molecule, and this effect depends on temperature [7]. Therefore, the abundance of clumped isotopes can be used as temperature indicator under thermodynamical equilibrium conditions. However, in the atmosphere, many reactions are controlled kinetically. It has been shown recently for a few examples that negative clumping signatures (anti-clumping) can be produced under non-equilibrium conditions [3,4]. In addition, based on purely statistical reasons, anti-clumping signatures will be produced in any molecule that contains indistinguishable atoms, which originate from isotopically distinct reservoir [5,6]. Thus, the investigation of multiply substituted isotopologues is expected to generate novel isotope signatures that can complement conventional stable isotope analysis in atmospheric science. We will present data on the performance of the MAT 253 ULTRA instrument and first scientific applications to atmospheric research. 1. Eiler, J.M., et al., A high-resolution gas

Food contaminant analysis at ultra-high mass resolution: application of hybrid linear ion trap - orbitrap mass spectrometry for the determination of the polyether toxins, azaspiracids, in shellfish.

LENUS (Irish Health Repository)

2010-10-30

The biotoxins, azaspiracids (AZAs), from marine phytoplankton accumulate in shellfish and affect human health by causing severe gastrointestinal disturbance, diarrhea, nausea and vomiting. Specific and sensitive methods have been developed and validated for the determination of the most commonly occurring azaspiracid analogs. An LTQ Orbitrap mass spectrometer is a hybrid instrument that combines linear ion trap (LIT) mass spectrometry (MS) with high-resolution Fourier transform (FT) MS and this was exploited to perform simultaneous ultra-high-resolution full-scan MS analysis and collision-induced dissociation (CID) tandem mass spectrometry (MS\\/MS). Using the highest mass resolution setting (100,000 FWHM) in full-scan mode, the methodology was validated for the determination of six AZAs in mussel (Mytilus galloprovincialis) tissue extracts. Ultra-high mass resolution, together with a narrow mass tolerance window of ±2 mDa, dramatically improved detection sensitivity. In addition to employing chromatographic resolution to distinguish between the isomeric azaspiracid analogs, AZA1\\/AZA6 and AZA4\\/AZA5, higher energy collisionally induced dissociation (HCD) fragmentation on selected precursor ions were performed in parallel with full-scan FTMS. Using HCD MS\\/MS, most precursor and product ion masses were determined within 1 ppm of the theoretical m\\/z values throughout the mass spectral range and this enhanced the reliability of analyte identity.For the analysis of mussels (M. galloprovincialis), the method limit of quantitation (LOQ) was 0.010 µg\\/g using full-scan FTMS and this was comparable with the LOQ (0.007 µg\\/g) using CID MS\\/MS. The repeatability data were; intra-day RSD% (1.8-4.4%; n = 6) and inter-day RSD% (4.7-8.6%; n = 3). Application of these methods to the analysis of mussels (M. edulis) that were naturally contaminated with azaspiracids, using high-resolution full-scan Orbitrap MS and low-resolution CID MS\\/MS, produced

Electron attachment to oxygen, ozone and other compounds of atmospheric relevance as studied with ultra-high energy resolution

International Nuclear Information System (INIS)

Maerk, T.D.; Matejcik, S.; Kiendler, A.; Cicman, P.; Senn, G.; Skalny, J.; Stampfli, P.; Illenberger, E.; Chu, Y.; Stamatovic, A.

1996-01-01

The processes of electron attachment to oxygen, ozone, ozone/oxygen cluster and oxygen cluster as well as other compounds of atmospheric relevance (CF 2 Cl 2 , CHCl 3 and CCl 3 Br) were studied with ultra-high energy resolution crossed beam technique

Multiple-image hiding using super resolution reconstruction in high-frequency domains

Science.gov (United States)

Li, Xiao-Wei; Zhao, Wu-Xiang; Wang, Jun; Wang, Qiong-Hua

2017-12-01

In this paper, a robust multiple-image hiding method using the computer-generated integral imaging and the modified super-resolution reconstruction algorithm is proposed. In our work, the host image is first transformed into frequency domains by cellular automata (CA), to assure the quality of the stego-image, the secret images are embedded into the CA high-frequency domains. The proposed method has the following advantages: (1) robustness to geometric attacks because of the memory-distributed property of elemental images, (2) increasing quality of the reconstructed secret images as the scheme utilizes the modified super-resolution reconstruction algorithm. The simulation results show that the proposed multiple-image hiding method outperforms other similar hiding methods and is robust to some geometric attacks, e.g., Gaussian noise and JPEG compression attacks.

Toward an ultra-high resolution community climate system model for the BlueGene platform

International Nuclear Information System (INIS)

Dennis, John M; Jacob, Robert; Vertenstein, Mariana; Craig, Tony; Loy, Raymond

2007-01-01

Global climate models need to simulate several small, regional-scale processes which affect the global circulation in order to accurately simulate the climate. This is particularly important in the ocean where small scale features such as oceanic eddies are currently represented with adhoc parameterizations. There is also a need for higher resolution to provide climate predictions at small, regional scales. New high-performance computing platforms such as the IBM BlueGene can provide the necessary computational power to perform ultra-high resolution climate model integrations. We have begun to investigate the scaling of the individual components of the Community Climate System Model to prepare it for integrations on BlueGene and similar platforms. Our investigations show that it is possible to successfully utilize O(32K) processors. We describe the scalability of five models: the Parallel Ocean Program (POP), the Community Ice CodE (CICE), the Community Land Model (CLM), and the new CCSM sequential coupler (CPL7) which are components of the next generation Community Climate System Model (CCSM); as well as the High-Order Method Modeling Environment (HOMME) which is a dynamical core currently being evaluated within the Community Atmospheric Model. For our studies we concentrate on 1/10 0 resolution for CICE, POP, and CLM models and 1/4 0 resolution for HOMME. The ability to simulate high resolutions on the massively parallel petascale systems that will dominate high-performance computing for the foreseeable future is essential to the advancement of climate science

A highly accurate spectral method for the Navier–Stokes equations in a semi-infinite domain with flexible boundary conditions

Energy Technology Data Exchange (ETDEWEB)

Matsushima, Toshiki; Ishioka, Keiichi, E-mail: matsushima@kugi.kyoto-u.ac.jp, E-mail: ishioka@gfd-dennou.org [Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502 (Japan)

2017-04-15

This paper presents a spectral method for numerically solving the Navier–Stokes equations in a semi-infinite domain bounded by a flat plane: the aim is to obtain high accuracy with flexible boundary conditions. The proposed use is for numerical simulations of small-scale atmospheric phenomena near the ground. We introduce basis functions that fit the semi-infinite domain, and an integral condition for vorticity is used to reduce the computational cost when solving the partial differential equations that appear when the viscosity term is treated implicitly. Furthermore, in order to ensure high accuracy, two iteration techniques are applied when solving the system of linear equations and in determining boundary values. This significantly reduces numerical errors, and the proposed method enables high-resolution numerical experiments. This is demonstrated by numerical experiments showing the collision of a vortex ring into a wall; these were performed using numerical models based on the proposed method. It is shown that the time evolution of the flow field is successfully obtained not only near the boundary, but also in a region far from the boundary. The applicability of the proposed method and the integral condition is discussed. (paper)

Atmospheric-water absorption features near 2.2 micrometers and their importance in high spectral resolution remote sensing

Science.gov (United States)

Kruse, F. A.; Clark, R. N.

1986-01-01

Selective absorption of electromagnetic radiation by atmospheric gases and water vapor is an accepted fact in terrestrial remote sensing. Until recently, only a general knowledge of atmospheric effects was required for analysis of remote sensing data; however, with the advent of high spectral resolution imaging devices, detailed knowledge of atmospheric absorption bands has become increasingly important for accurate analysis. Detailed study of high spectral resolution aircraft data at the U.S. Geological Survey has disclosed narrow absorption features centered at approximately 2.17 and 2.20 micrometers not caused by surface mineralogy. Published atmospheric transmission spectra and atmospheric spectra derived using the LOWTRAN-5 computer model indicate that these absorption features are probably water vapor. Spectral modeling indicates that the effects of atmospheric absorption in this region are most pronounced in spectrally flat materials with only weak absorption bands. Without correction and detailed knowledge of the atmospheric effects, accurate mapping of surface mineralogy (particularly at low mineral concentrations) is not possible.

INTRASURGICAL MICROSCOPE-INTEGRATED SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-ASSISTED MEMBRANE PEELING.

Science.gov (United States)

Falkner-Radler, Christiane I; Glittenberg, Carl; Gabriel, Max; Binder, Susanne

2015-10-01

To evaluate microscope-integrated intrasurgical spectral domain optical coherence tomography during macular surgery in a prospective monocenter study. Before pars plana vitrectomy and before, during, and after membrane peeling, 512 × 128 macular cube scans were performed using a Carl Zeiss Meditec Cirrus high-definition OCT system adapted to the optical pathway of a Zeiss OPMI VISU 200 surgical microscope and compared with retinal staining. The study included 51 patients with epiretinal membranes, with 8 of those having additional lamellar macular holes, 11 patients with vitreomacular traction, and 8 patients with full-thickness macular holes. Intraoperative spectral domain optical coherence tomography allowed performing membrane peeling without using retinal dyes in 40% of cases (28 of 70 patients). No residual membranes were found in 94.3% of patients (66 of 70 patients) in intrasurgical spectral domain optical coherence tomography and subsequent (re)staining. In patients with vitreomacular traction, intrasurgical spectral domain optical coherence tomography scans facilitated decisions on the need for an intraocular tamponade after membrane peeling. Intraoperative spectral domain optical coherence tomography was comparable with retinal dyes in confirming success after membrane peeling. However, the visualization of flat membranes was better after staining.

An ultrastable Michelson interferometer for high-resolution spectroscopy in the XUV.

Science.gov (United States)

Corsi, C; Liontos, I; Cavalieri, S; Bellini, M; Venturi, G; Eramo, R

2015-02-23

We developed an ultra-stable and accurately-controllable Michelson interferometer to be used in a deeply unbalanced arm configuration for split-pulse XUV Ramsey-type spectroscopy with high-order laser harmonics. The implemented active and passive stabilization systems allow one to reach instabilities in the nanometer range over meters of relative optical path differences. Producing precisely delayed pairs of pump pulses will generate XUV harmonic pulses that may significantly improve the achievable spectral resolution and the precision of absolute frequency measurements in the XUV.

Toward an ultra-high resolution community climate system model for the BlueGene platform

Energy Technology Data Exchange (ETDEWEB)

Dennis, John M [Computer Science Section, National Center for Atmospheric Research, Boulder, CO (United States); Jacob, Robert [Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL (United States); Vertenstein, Mariana [Climate and Global Dynamics Division, National Center for Atmospheric Research, Boulder, CO (United States); Craig, Tony [Climate and Global Dynamics Division, National Center for Atmospheric Research, Boulder, CO (United States); Loy, Raymond [Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL (United States)

2007-07-15

Global climate models need to simulate several small, regional-scale processes which affect the global circulation in order to accurately simulate the climate. This is particularly important in the ocean where small scale features such as oceanic eddies are currently represented with adhoc parameterizations. There is also a need for higher resolution to provide climate predictions at small, regional scales. New high-performance computing platforms such as the IBM BlueGene can provide the necessary computational power to perform ultra-high resolution climate model integrations. We have begun to investigate the scaling of the individual components of the Community Climate System Model to prepare it for integrations on BlueGene and similar platforms. Our investigations show that it is possible to successfully utilize O(32K) processors. We describe the scalability of five models: the Parallel Ocean Program (POP), the Community Ice CodE (CICE), the Community Land Model (CLM), and the new CCSM sequential coupler (CPL7) which are components of the next generation Community Climate System Model (CCSM); as well as the High-Order Method Modeling Environment (HOMME) which is a dynamical core currently being evaluated within the Community Atmospheric Model. For our studies we concentrate on 1/10{sup 0} resolution for CICE, POP, and CLM models and 1/4{sup 0} resolution for HOMME. The ability to simulate high resolutions on the massively parallel petascale systems that will dominate high-performance computing for the foreseeable future is essential to the advancement of climate science.

Role of light satellites in the high-resolution Earth observation domain

Science.gov (United States)

Fishman, Moshe

1999-12-01

Current 'classic' applications using and exploring space based earth imagery are exclusive, narrow niche tailored, expensive and hardly accessible. On the other side new, inexpensive and widely used 'consumable' applications will be only developed concurrently to the availability of appropriate imagery allowing that process. A part of these applications can be imagined today, like WWW based 'virtual tourism' or news media, but the history of technological, cultural and entertainment evolution teaches us that most of future applications are unpredictable -- they emerge together with the platforms enabling their appearance. The only thing, which can be ultimately stated, is that the definitive condition for such applications is the availability of the proper imagery platform providing low cost, high resolution, large area, quick response, simple accessibility and quick dissemination of the raw picture. This platform is a constellation of Earth Observation satellites. Up to 1995 the Space Based High Resolution Earth Observation Domain was dominated by heavy, super-expensive and very inflexible birds. The launch of Israeli OFEQ-3 Satellite by MBT Division of Israel Aircraft Industries (IAI) marked the entrance to new era of light, smart and cheap Low Earth Orbited Imaging satellites. The Earth Resource Observation System (EROS) initiated by West Indian Space, is based on OFEQ class Satellites design and it is capable to gather visual data of Earth Surface both at high resolution and large image capacity. The main attributes, derived from its compact design, low weight and sophisticated logic and which convert the EROS Satellite to valuable and productive system, are discussed. The major advantages of Light Satellites in High Resolution Earth Observation Domain are presented and WIS guidelines featuring the next generation of LEO Imaging Systems are included.

Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis.

Science.gov (United States)

Spraggins, Jeffrey M; Rizzo, David G; Moore, Jessica L; Noto, Michael J; Skaar, Eric P; Caprioli, Richard M

2016-06-01

MALDI imaging mass spectrometry is a powerful analytical tool enabling the visualization of biomolecules in tissue. However, there are unique challenges associated with protein imaging experiments including the need for higher spatial resolution capabilities, improved image acquisition rates, and better molecular specificity. Here we demonstrate the capabilities of ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR IMS platforms as they relate to these challenges. High spatial resolution MALDI-TOF protein images of rat brain tissue and cystic fibrosis lung tissue were acquired at image acquisition rates >25 pixels/s. Structures as small as 50 μm were spatially resolved and proteins associated with host immune response were observed in cystic fibrosis lung tissue. Ultra-high speed MALDI-TOF enables unique applications including megapixel molecular imaging as demonstrated for lipid analysis of cystic fibrosis lung tissue. Additionally, imaging experiments using MALDI FTICR IMS were shown to produce data with high mass accuracy (z 5000) for proteins up to ∼20 kDa. Analysis of clear cell renal cell carcinoma using MALDI FTICR IMS identified specific proteins localized to healthy tissue regions, within the tumor, and also in areas of increased vascularization around the tumor. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A feasibility study of PETiPIX: an ultra high resolution small animal PET scanner

Science.gov (United States)

Li, K.; Safavi-Naeini, M.; Franklin, D. R.; Petasecca, M.; Guatelli, S.; Rosenfeld, A. B.; Hutton, B. F.; Lerch, M. L. F.

2013-12-01

PETiPIX is an ultra high spatial resolution positron emission tomography (PET) scanner designed for imaging mice brains. Four Timepix pixellated silicon detector modules are placed in an edge-on configuration to form a scanner with a field of view (FoV) 15 mm in diameter. Each detector module consists of 256 × 256 pixels with dimensions of 55 × 55 × 300 μm3. Monte Carlo simulations using GEANT4 Application for Tomographic Emission (GATE) were performed to evaluate the feasibility of the PETiPIX design, including estimation of system sensitivity, angular dependence, spatial resolution (point source, hot and cold phantom studies) and evaluation of potential detector shield designs. Initial experimental work also established that scattered photons and recoil electrons could be detected using a single edge-on Timepix detector with a positron source. Simulation results estimate a spatial resolution of 0.26 mm full width at half maximum (FWHM) at the centre of FoV and 0.29 mm FWHM overall spatial resolution with sensitivity of 0.01%, and indicate that a 1.5 mm thick tungsten shield parallel to the detectors will absorb the majority of non-coplanar annihilation photons, significantly reducing the rates of randoms. Results from the simulated phantom studies demonstrate that PETiPIX is a promising design for studies demanding high resolution images of mice brains.

Effects of NMR spectral resolution on protein structure calculation.

Directory of Open Access Journals (Sweden)

Suhas Tikole

Full Text Available Adequate digital resolution and signal sensitivity are two critical factors for protein structure determinations by solution NMR spectroscopy. The prime objective for obtaining high digital resolution is to resolve peak overlap, especially in NOESY spectra with thousands of signals where the signal analysis needs to be performed on a large scale. Achieving maximum digital resolution is usually limited by the practically available measurement time. We developed a method utilizing non-uniform sampling for balancing digital resolution and signal sensitivity, and performed a large-scale analysis of the effect of the digital resolution on the accuracy of the resulting protein structures. Structure calculations were performed as a function of digital resolution for about 400 proteins with molecular sizes ranging between 5 and 33 kDa. The structural accuracy was assessed by atomic coordinate RMSD values from the reference structures of the proteins. In addition, we monitored also the number of assigned NOESY cross peaks, the average signal sensitivity, and the chemical shift spectral overlap. We show that high resolution is equally important for proteins of every molecular size. The chemical shift spectral overlap depends strongly on the corresponding spectral digital resolution. Thus, knowing the extent of overlap can be a predictor of the resulting structural accuracy. Our results show that for every molecular size a minimal digital resolution, corresponding to the natural linewidth, needs to be achieved for obtaining the highest accuracy possible for the given protein size using state-of-the-art automated NOESY assignment and structure calculation methods.

Advanced Ecosystem Mapping Techniques for Large Arctic Study Domains Using Calibrated High-Resolution Imagery

Science.gov (United States)

Macander, M. J.; Frost, G. V., Jr.

2015-12-01

Regional-scale mapping of vegetation and other ecosystem properties has traditionally relied on medium-resolution remote sensing such as Landsat (30 m) and MODIS (250 m). Yet, the burgeoning availability of high-resolution (environments has not been previously evaluated. Image segmentation, or object-based image analysis, automatically partitions high-resolution imagery into homogeneous image regions that can then be analyzed based on spectral, textural, and contextual information. We applied eCognition software to delineate waterbodies and vegetation classes, in combination with other techniques. Texture metrics were evaluated to determine the feasibility of using high-resolution imagery to algorithmically characterize periglacial surface forms (e.g., ice-wedge polygons), which are an important physical characteristic of permafrost-dominated regions but which cannot be distinguished by medium-resolution remote sensing. These advanced mapping techniques provide products which can provide essential information supporting a broad range of ecosystem science and land-use planning applications in northern Alaska and elsewhere in the circumpolar Arctic.

Application of ultra-fast high-resolution gated-image intensifiers to laser fusion studies

International Nuclear Information System (INIS)

Lieber, A.J.; Benjamin, R.F.; Sutphin, H.D.; McCall, G.H.

1975-01-01

Gated-image intensifiers for fast framing have found high utility in laser-target interaction studies. X-ray pinhole camera photographs which can record asymmetries of laser-target interactions have been instrumental in further system design. High-resolution high-speed x-ray images of laser irradiated targets are formed using pinhole optics and electronically amplified by proximity focused channelplate intensifiers before being recorded on film. Spectral resolution is obtained by filtering. In these applications shutter duration is determined by source duration. Electronic gating serves to reduce background thereby enhancing signal-to-noise ratio. Cameras are used to view the self light of the interaction but may also be used for shadowgraphs. Sources for shadowgraphs may be sequenced to obtain a series of pictures with effective rates of 10 10 frame/s. Multiple aperatures have been used to obtain stereo x-ray views, yielding three dimensional information about the interactions. (author)

The Combined ASTER MODIS Emissivity over Land (CAMEL Part 1: Methodology and High Spectral Resolution Application

Directory of Open Access Journals (Sweden)

E. Eva Borbas

2018-04-01

Full Text Available As part of a National Aeronautics and Space Administration (NASA MEaSUREs (Making Earth System Data Records for Use in Research Environments Land Surface Temperature and Emissivity project, the Space Science and Engineering Center (UW-Madison and the NASA Jet Propulsion Laboratory (JPL developed a global monthly mean emissivity Earth System Data Record (ESDR. This new Combined ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer and MODIS (Moderate Resolution Imaging Spectroradiometer Emissivity over Land (CAMEL ESDR was produced by merging two current state-of-the-art emissivity datasets: the UW-Madison MODIS Infrared emissivity dataset (UW BF and the JPL ASTER Global Emissivity Dataset Version 4 (GEDv4. The dataset includes monthly global records of emissivity and related uncertainties at 13 hinge points between 3.6–14.3 µm, as well as principal component analysis (PCA coefficients at 5-km resolution for the years 2000 through 2016. A high spectral resolution (HSR algorithm is provided for HSR applications. This paper describes the 13 hinge-points combination methodology and the high spectral resolutions algorithm, as well as reports the current status of the dataset.

Comparison between various patch wise strategies for reconstruction of ultra-spectral cubes captured with a compressive sensing system

Science.gov (United States)

Oiknine, Yaniv; August, Isaac Y.; Revah, Liat; Stern, Adrian

2016-05-01

Recently we introduced a Compressive Sensing Miniature Ultra-Spectral Imaging (CS-MUSI) system. The system is based on a single Liquid Crystal (LC) cell and a parallel sensor array where the liquid crystal cell performs spectral encoding. Within the framework of compressive sensing, the CS-MUSI system is able to reconstruct ultra-spectral cubes captured with only an amount of ~10% samples compared to a conventional system. Despite the compression, the technique is extremely complex computationally, because reconstruction of ultra-spectral images requires processing huge data cubes of Gigavoxel size. Fortunately, the computational effort can be alleviated by using separable operation. An additional way to reduce the reconstruction effort is to perform the reconstructions on patches. In this work, we consider processing on various patch shapes. We present an experimental comparison between various patch shapes chosen to process the ultra-spectral data captured with CS-MUSI system. The patches may be one dimensional (1D) for which the reconstruction is carried out spatially pixel-wise, or two dimensional (2D) - working on spatial rows/columns of the ultra-spectral cube, as well as three dimensional (3D).

High Spectral Resolution Lidar Based on a Potassium Faraday Dispersive Filter for Daytime Temperature Measurement

Directory of Open Access Journals (Sweden)

Abo Makoto

2016-01-01

Full Text Available In this paper, a new high-spectral-resolution lidar technique is proposed for measuring the profiles of atmospheric temperature in daytime. Based on the theory of high resolution Rayleigh scattering, the feasibility and advantages of using potassium (K Faraday dispersive optical filters as blocking filters for measuring atmospheric temperature are demonstrated with a numerical simulation. It was found that temperature profiles could be measured within 1K error for the height of 9 km with a 500 m range resolution in 60 min by using laser pulses with 1mJ/pulse and 1 kHz, and a 50 cm diameter telescope. Furthermore, we are developing compact pulsed laser system for temperature lidar transmitter.

Ultra-high-speed Optical Signal Processing using Silicon Photonics

DEFF Research Database (Denmark)

Oxenløwe, Leif Katsuo; Ji, Hua; Jensen, Asger Sellerup

with a photonic layer on top to interconnect them. For such systems, silicon is an attractive candidate enabling both electronic and photonic control. For some network scenarios, it may be beneficial to use optical on-chip packet switching, and for high data-density environments one may take advantage...... of the ultra-fast nonlinear response of silicon photonic waveguides. These chips offer ultra-broadband wavelength operation, ultra-high timing resolution and ultra-fast response, and when used appropriately offer energy-efficient switching. In this presentation we review some all-optical functionalities based...... on silicon photonics. In particular we use nano-engineered silicon waveguides (nanowires) [1] enabling efficient phasematched four-wave mixing (FWM), cross-phase modulation (XPM) or self-phase modulation (SPM) for ultra-high-speed optical signal processing of ultra-high bit rate serial data signals. We show...

Three-dimensional, time-resolved profiling of ferroelectric domain wall dynamics by spectral-domain optical coherence tomography

International Nuclear Information System (INIS)

Haussmann, Alexander; Schmidt, Sebastian; Wehmeier, Lukas; Eng, Lukas M.; Kirsten, Lars; Cimalla, Peter; Koch, Edmund

2017-01-01

We apply here spectral-domain optical coherence tomography (SD-OCT) for the precise detection and temporal tracking of ferroelectric domain walls (DWs) in magnesium-doped periodically poled lithium niobate (Mg:PPLN). We reproducibly map static DWs at an axial (depth) resolution down to ∝ 0.6 μm, being located up to 0.5 mm well inside the single crystalline Mg:PPLN sample. We show that a full 3-dimensional (3D) reconstruction of the DW geometry is possible from the collected data, when applying a special algorithm that accounts for the nonlinear optical dispersion of the material. Our OCT investigation provides valuable reference information on the DWs' polarization charge distribution, which is known to be the key to the electrical conductivity of ferroelectric DWs in such systems. Hence, we carefully analyze the SD-OCT signal dependence both when varying the direction of incident polarization, and when applying electrical fields along the polar axis. Surprisingly, the large backreflection intensities recorded under extraordinary polarization are not affected by any electrical field, at least for field strengths below the switching threshold, while no significant signals above noise floor are detected under ordinary polarization. Finally, we employed the high-speed SD-OCT setup for the real-time DW tracking upon ferroelectric domain switching under high external fields. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Three-dimensional, time-resolved profiling of ferroelectric domain wall dynamics by spectral-domain optical coherence tomography

Energy Technology Data Exchange (ETDEWEB)

Haussmann, Alexander; Schmidt, Sebastian; Wehmeier, Lukas; Eng, Lukas M. [Technische Universitaet Dresden, Institute of Applied Physics and Center for Advancing Electronics Dresden (cfaed), Dresden (Germany); Kirsten, Lars; Cimalla, Peter; Koch, Edmund [Technische Universitaet Dresden, Faculty of Medicine Carl Gustav Carus, Anesthesiology and Intensive Care Medicine, Clinical Sensoring and Monitoring, Dresden (Germany)

2017-08-15

We apply here spectral-domain optical coherence tomography (SD-OCT) for the precise detection and temporal tracking of ferroelectric domain walls (DWs) in magnesium-doped periodically poled lithium niobate (Mg:PPLN). We reproducibly map static DWs at an axial (depth) resolution down to ∝ 0.6 μm, being located up to 0.5 mm well inside the single crystalline Mg:PPLN sample. We show that a full 3-dimensional (3D) reconstruction of the DW geometry is possible from the collected data, when applying a special algorithm that accounts for the nonlinear optical dispersion of the material. Our OCT investigation provides valuable reference information on the DWs' polarization charge distribution, which is known to be the key to the electrical conductivity of ferroelectric DWs in such systems. Hence, we carefully analyze the SD-OCT signal dependence both when varying the direction of incident polarization, and when applying electrical fields along the polar axis. Surprisingly, the large backreflection intensities recorded under extraordinary polarization are not affected by any electrical field, at least for field strengths below the switching threshold, while no significant signals above noise floor are detected under ordinary polarization. Finally, we employed the high-speed SD-OCT setup for the real-time DW tracking upon ferroelectric domain switching under high external fields. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Ultra-high resolution AMOLED

Science.gov (United States)

Wacyk, Ihor; Prache, Olivier; Ghosh, Amal

2011-06-01

AMOLED microdisplays continue to show improvement in resolution and optical performance, enhancing their appeal for a broad range of near-eye applications such as night vision, simulation and training, situational awareness, augmented reality, medical imaging, and mobile video entertainment and gaming. eMagin's latest development of an HDTV+ resolution technology integrates an OLED pixel of 3.2 × 9.6 microns in size on a 0.18 micron CMOS backplane to deliver significant new functionality as well as the capability to implement a 1920×1200 microdisplay in a 0.86" diagonal area. In addition to the conventional matrix addressing circuitry, the HDTV+ display includes a very lowpower, low-voltage-differential-signaling (LVDS) serialized interface to minimize cable and connector size as well as electromagnetic emissions (EMI), an on-chip set of look-up-tables for digital gamma correction, and a novel pulsewidth- modulation (PWM) scheme that together with the standard analog control provides a total dimming range of 0.05cd/m2 to 2000cd/m2 in the monochrome version. The PWM function also enables an impulse drive mode of operation that significantly reduces motion artifacts in high speed scene changes. An internal 10-bit DAC ensures that a full 256 gamma-corrected gray levels are available across the entire dimming range, resulting in a measured dynamic range exceeding 20-bits. This device has been successfully tested for operation at frame rates ranging from 30Hz up to 85Hz. This paper describes the operational features and detailed optical and electrical test results for the new AMOLED WUXGA resolution microdisplay.

High-Resolution Spectral Measurement of High Temperature CO2 and H2O.

Science.gov (United States)

1980-12-01

a major constituent which critically controls the infrared radiative transfer in the telluric atmosphere. Their absorption bands are distributed over... movement to prevent cracking. Also, the continuous Q = s/) spectrum spectral coverage filament ceramic fiber, brand AB-312 manufactured by resolution the 3M

Transient spectral domain optical coherence tomography findings in classic MEWDS: a case report.

Science.gov (United States)

Lavigne, Luciana Castro; Isaac, David Leonardo Cruvinel; Duarte Júnior, José Osório; Avila, Marcos Pereira de

2014-01-01

The purpose of this study was to describe a patient with multiple evanescent white dot syndrome (MEWDS) who presented with classic retinal findings and transient changes in outer retinal anatomy. A 20-year-old man presented with mild blurred vision in the left eye, reporting flu-like symptoms 1 week before the visual symptoms started. Fundus examination of the left eye revealed foveal granularity and multiple scattered spots deep to the retina in the posterior pole. Fluorescein angiography and indocyanine green angiography showed typical MEWDS findings. Spectral Domain Optical Coherence Tomography has shown transient changes in outer retinal anatomy with disappearance of inner segment-outer segment junction and mild attenuation of external limiting membrane. Six months later, Spectral Domain Optical Coherence Tomography has shown complete resolution with recovery of normal outer retinal aspect.

Ultra-high-resolution CT angiography of the artery of Adamkiewicz. A feasibility study

Energy Technology Data Exchange (ETDEWEB)

Yoshioka, Kunihiro; Tanaka, Ryoichi; Takagi, Hidenobu [Iwate Medical University, Division of Cardiovascular Radiology, Department of Radiology, Morioka (Japan); Ueyama, Yuta; Kikuchi, Kei; Chiba, Takuya [Iwate Medical University Hospital, Center for Radiological Science, Morioka (Japan); Arakita, Kazumasa [Center for Medical Research and Development, Toshiba Medical Systems Corporation, Otawara (Japan); Schuijf, Joanne D. [Center for Medical Research and Development Europe, Toshiba Medical Systems Europe, Zoetermeer (Netherlands); Saito, Yasuo [CT Systems Development Department, Toshiba Medical Systems Corporation, Otawara (Japan)

2018-01-15

Preoperative identification of the artery of Adamkiewicz can help prevent postoperative spinal cord injury following thoracic and thoracoabdominal aortic repair. Several studies have demonstrated the feasibility of evaluating the artery of Adamkiewicz using multi-detector row computed tomography (CT), but precise visualization remains a challenge. The present study was conducted to evaluate the usefulness of ultra-high-resolution CT for visualizing the artery of Adamkiewicz with a slice thickness of 0.25 versus 0.5 mm in patients with aortic aneurysms. Our institutional review board approved this study. Twenty-four patients with thoracic and thoracoabdominal aneurysms were scanned with beam collimation of 0.25 mm x 128. Images were reconstructed with slice thicknesses of 0.25 and 0.5 mm. The signal-to-noise ratio (SNR) of the aorta and contrast-to-noise ratio (CNR) between the anterior spinal artery and spinal cord were measured. Two independent observers evaluated visualization of the artery of Adamkiewicz and its continuity between the anterior spinal artery and the aorta using a four-point scale. No significant differences in the SNR of the aorta or CNR of the anterior spinal artery were observed between 0.25- and 0.5-mm slices. The average visualization score was significantly higher for 0.25-mm slices (3.58 ± 0.78) than for 0.5-mm slices (3.13 ± 0.99) (p = 0.01). The percentage of patients with nondiagnostic image quality was significantly lower for 0.25-mm slices (8.3%) than for 0.5-mm slices (33.3%) (p = 0.03). In patients with aortic aneurysms, ultra-high-resolution CT with 0.25-mm slices significantly improves visualization of the artery of Adamkiewicz compared to 0.5-mm slices. (orig.)

(LMRG): Microscope Resolution, Objective Quality, Spectral Accuracy and Spectral Un-mixing

Science.gov (United States)

Bayles, Carol J.; Cole, Richard W.; Eason, Brady; Girard, Anne-Marie; Jinadasa, Tushare; Martin, Karen; McNamara, George; Opansky, Cynthia; Schulz, Katherine; Thibault, Marc; Brown, Claire M.

2012-01-01

The second study by the LMRG focuses on measuring confocal laser scanning microscope (CLSM) resolution, objective lens quality, spectral imaging accuracy and spectral un-mixing. Affordable test samples for each aspect of the study were designed, prepared and sent to 116 labs from 23 countries across the globe. Detailed protocols were designed for the three tests and customized for most of the major confocal instruments being used by the study participants. One protocol developed for measuring resolution and objective quality was recently published in Nature Protocols (Cole, R. W., T. Jinadasa, et al. (2011). Nature Protocols 6(12): 1929–1941). The first study involved 3D imaging of sub-resolution fluorescent microspheres to determine the microscope point spread function. Results of the resolution studies as well as point spread function quality (i.e. objective lens quality) from 140 different objective lenses will be presented. The second study of spectral accuracy looked at the reflection of the laser excitation lines into the spectral detection in order to determine the accuracy of these systems to report back the accurate laser emission wavelengths. Results will be presented from 42 different spectral confocal systems. Finally, samples with double orange beads (orange core and orange coating) were imaged spectrally and the imaging software was used to un-mix fluorescence signals from the two orange dyes. Results from 26 different confocal systems will be summarized. Time will be left to discuss possibilities for the next LMRG study.

Assessment of modern spectral analysis methods to improve wavenumber resolution of F-K spectra

International Nuclear Information System (INIS)

Shirley, T.E.; Laster, S.J.; Meek, R.A.

1987-01-01

The improvement in wavenumber spectra obtained by using high resolution spectral estimators is examined. Three modern spectral estimators were tested, namely the Autoregressive/Maximum Entropy (AR/ME) method, the Extended Prony method, and an eigenstructure method. They were combined with the conventional Fourier method by first transforming each trace with a Fast Fourier Transform (FFT). A high resolution spectral estimator was applied to the resulting complex spatial sequence for each frequency. The collection of wavenumber spectra thus computed comprises a hybrid f-k spectrum with high wavenumber resolution and less spectral ringing. Synthetic and real data records containing 25 traces were analyzed by using the hybrid f-k method. The results show an FFT-AR/ME f-k spectrum has noticeably better wavenumber resolution and more spectral dynamic range than conventional spectra when the number of channels is small. The observed improvement suggests the hybrid technique is potentially valuable in seismic data analysis

Demonstration of a diode-laser-based high spectral resolution lidar (HSRL) for quantitative profiling of clouds and aerosols.

Science.gov (United States)

Hayman, Matthew; Spuler, Scott

2017-11-27

We present a demonstration of a diode-laser-based high spectral resolution lidar. It is capable of performing calibrated retrievals of aerosol and cloud optical properties at a 150 m range resolution with less than 1 minute integration time over an approximate range of 12 km during day and night. This instrument operates at 780 nm, a wavelength that is well established for reliable semiconductor lasers and detectors, and was chosen because it corresponds to the D2 rubidium absorption line. A heated vapor reference cell of isotopic rubidium 87 is used as an effective and reliable aerosol signal blocking filter in the instrument. In principle, the diode-laser-based high spectral resolution lidar can be made cost competitive with elastic backscatter lidar systems, yet delivers a significant improvement in data quality through direct retrieval of quantitative optical properties of clouds and aerosols.

A high-resolution two-pulse coherent anti-Stokes Raman scattering spectrum using a spectral amplitude modulation

International Nuclear Information System (INIS)

Lu, Chenhui; Zhang, Shian; Wu, Meizhen; Jia, Tianqing; Sun, Zhenrong; Qiu, Jianrong

2013-01-01

Femtosecond coherent anti-Stokes Raman scattering (CARS) spectra suffer from low spectral resolution because of the broadband laser spectrum. In this paper, we propose a feasible scheme to achieve a high-resolution two-pulse CARS spectrum by shaping both the pump and probe pulses using rectangular amplitude modulation. We show that a narrowband hole in the CARS spectrum can be created by the amplitude-shaped laser pulse, the position of which is correlated with the Raman resonant frequency of the molecule. Thus, by observing holes in the CARS spectrum, we are able to obtain a high-resolution CARS spectrum and the energy-level diagram of the molecule. (paper)

Breast density estimation from high spectral and spatial resolution MRI

Science.gov (United States)

Li, Hui; Weiss, William A.; Medved, Milica; Abe, Hiroyuki; Newstead, Gillian M.; Karczmar, Gregory S.; Giger, Maryellen L.

2016-01-01

Abstract. A three-dimensional breast density estimation method is presented for high spectral and spatial resolution (HiSS) MR imaging. Twenty-two patients were recruited (under an Institutional Review Board--approved Health Insurance Portability and Accountability Act-compliant protocol) for high-risk breast cancer screening. Each patient received standard-of-care clinical digital x-ray mammograms and MR scans, as well as HiSS scans. The algorithm for breast density estimation includes breast mask generating, breast skin removal, and breast percentage density calculation. The inter- and intra-user variabilities of the HiSS-based density estimation were determined using correlation analysis and limits of agreement. Correlation analysis was also performed between the HiSS-based density estimation and radiologists’ breast imaging-reporting and data system (BI-RADS) density ratings. A correlation coefficient of 0.91 (pdensity estimations. An interclass correlation coefficient of 0.99 (pdensity estimations. A moderate correlation coefficient of 0.55 (p=0.0076) was observed between HiSS-based breast density estimations and radiologists’ BI-RADS. In summary, an objective density estimation method using HiSS spectral data from breast MRI was developed. The high reproducibility with low inter- and low intra-user variabilities shown in this preliminary study suggest that such a HiSS-based density metric may be potentially beneficial in programs requiring breast density such as in breast cancer risk assessment and monitoring effects of therapy. PMID:28042590

Enhanced Isotopic Ratio Outlier Analysis (IROA Peak Detection and Identification with Ultra-High Resolution GC-Orbitrap/MS: Potential Application for Investigation of Model Organism Metabolomes

Directory of Open Access Journals (Sweden)

Yunping Qiu

2018-01-01

Full Text Available Identifying non-annotated peaks may have a significant impact on the understanding of biological systems. In silico methodologies have focused on ESI LC/MS/MS for identifying non-annotated MS peaks. In this study, we employed in silico methodology to develop an Isotopic Ratio Outlier Analysis (IROA workflow using enhanced mass spectrometric data acquired with the ultra-high resolution GC-Orbitrap/MS to determine the identity of non-annotated metabolites. The higher resolution of the GC-Orbitrap/MS, together with its wide dynamic range, resulted in more IROA peak pairs detected, and increased reliability of chemical formulae generation (CFG. IROA uses two different 13C-enriched carbon sources (randomized 95% 12C and 95% 13C to produce mirror image isotopologue pairs, whose mass difference reveals the carbon chain length (n, which aids in the identification of endogenous metabolites. Accurate m/z, n, and derivatization information are obtained from our GC/MS workflow for unknown metabolite identification, and aids in silico methodologies for identifying isomeric and non-annotated metabolites. We were able to mine more mass spectral information using the same Saccharomyces cerevisiae growth protocol (Qiu et al. Anal. Chem 2016 with the ultra-high resolution GC-Orbitrap/MS, using 10% ammonia in methane as the CI reagent gas. We identified 244 IROA peaks pairs, which significantly increased IROA detection capability compared with our previous report (126 IROA peak pairs using a GC-TOF/MS machine. For 55 selected metabolites identified from matched IROA CI and EI spectra, using the GC-Orbitrap/MS vs. GC-TOF/MS, the average mass deviation for GC-Orbitrap/MS was 1.48 ppm, however, the average mass deviation was 32.2 ppm for the GC-TOF/MS machine. In summary, the higher resolution and wider dynamic range of the GC-Orbitrap/MS enabled more accurate CFG, and the coupling of accurate mass GC/MS IROA methodology with in silico fragmentation has great

Enhanced Isotopic Ratio Outlier Analysis (IROA) Peak Detection and Identification with Ultra-High Resolution GC-Orbitrap/MS: Potential Application for Investigation of Model Organism Metabolomes.

Science.gov (United States)

Qiu, Yunping; Moir, Robyn D; Willis, Ian M; Seethapathy, Suresh; Biniakewitz, Robert C; Kurland, Irwin J

2018-01-18

Identifying non-annotated peaks may have a significant impact on the understanding of biological systems. In silico methodologies have focused on ESI LC/MS/MS for identifying non-annotated MS peaks. In this study, we employed in silico methodology to develop an Isotopic Ratio Outlier Analysis (IROA) workflow using enhanced mass spectrometric data acquired with the ultra-high resolution GC-Orbitrap/MS to determine the identity of non-annotated metabolites. The higher resolution of the GC-Orbitrap/MS, together with its wide dynamic range, resulted in more IROA peak pairs detected, and increased reliability of chemical formulae generation (CFG). IROA uses two different 13 C-enriched carbon sources (randomized 95% 12 C and 95% 13 C) to produce mirror image isotopologue pairs, whose mass difference reveals the carbon chain length (n), which aids in the identification of endogenous metabolites. Accurate m/z, n, and derivatization information are obtained from our GC/MS workflow for unknown metabolite identification, and aids in silico methodologies for identifying isomeric and non-annotated metabolites. We were able to mine more mass spectral information using the same Saccharomyces cerevisiae growth protocol (Qiu et al. Anal. Chem 2016) with the ultra-high resolution GC-Orbitrap/MS, using 10% ammonia in methane as the CI reagent gas. We identified 244 IROA peaks pairs, which significantly increased IROA detection capability compared with our previous report (126 IROA peak pairs using a GC-TOF/MS machine). For 55 selected metabolites identified from matched IROA CI and EI spectra, using the GC-Orbitrap/MS vs. GC-TOF/MS, the average mass deviation for GC-Orbitrap/MS was 1.48 ppm, however, the average mass deviation was 32.2 ppm for the GC-TOF/MS machine. In summary, the higher resolution and wider dynamic range of the GC-Orbitrap/MS enabled more accurate CFG, and the coupling of accurate mass GC/MS IROA methodology with in silico fragmentation has great potential in

Stable multi-domain spectral penalty methods for fractional partial differential equations

Science.gov (United States)

Xu, Qinwu; Hesthaven, Jan S.

2014-01-01

We propose stable multi-domain spectral penalty methods suitable for solving fractional partial differential equations with fractional derivatives of any order. First, a high order discretization is proposed to approximate fractional derivatives of any order on any given grids based on orthogonal polynomials. The approximation order is analyzed and verified through numerical examples. Based on the discrete fractional derivative, we introduce stable multi-domain spectral penalty methods for solving fractional advection and diffusion equations. The equations are discretized in each sub-domain separately and the global schemes are obtained by weakly imposed boundary and interface conditions through a penalty term. Stability of the schemes are analyzed and numerical examples based on both uniform and nonuniform grids are considered to highlight the flexibility and high accuracy of the proposed schemes.

STUDY ON HIGH RESOLUTION MEMBRANE-BASED DIFFRACTIVE OPTICAL IMAGING ON GEOSTATIONARY ORBIT

Directory of Open Access Journals (Sweden)

J. Jiao

2017-05-01

Full Text Available Diffractive optical imaging technology provides a new way to realize high resolution earth observation on geostationary orbit. There are a lot of benefits to use the membrane-based diffractive optical element in ultra-large aperture optical imaging system, including loose tolerance, light weight, easy folding and unfolding, which make it easy to realize high resolution earth observation on geostationary orbit. The implementation of this technology also faces some challenges, including the configuration of the diffractive primary lens, the development of high diffraction efficiency membrane-based diffractive optical elements, and the correction of the chromatic aberration of the diffractive optical elements. Aiming at the configuration of the diffractive primary lens, the “6+1” petal-type unfold scheme is proposed, which consider the compression ratio, the blocking rate and the development complexity. For high diffraction efficiency membrane-based diffractive optical element, a self-collimating method is proposed. The diffraction efficiency is more than 90 % of the theoretical value. For the chromatic aberration correction problem, an optimization method based on schupmann is proposed to make the imaging spectral bandwidth in visible light band reach 100 nm. The above conclusions have reference significance for the development of ultra-large aperture diffractive optical imaging system.

Study on High Resolution Membrane-Based Diffractive Optical Imaging on Geostationary Orbit

Science.gov (United States)

Jiao, J.; Wang, B.; Wang, C.; Zhang, Y.; Jin, J.; Liu, Z.; Su, Y.; Ruan, N.

2017-05-01

Diffractive optical imaging technology provides a new way to realize high resolution earth observation on geostationary orbit. There are a lot of benefits to use the membrane-based diffractive optical element in ultra-large aperture optical imaging system, including loose tolerance, light weight, easy folding and unfolding, which make it easy to realize high resolution earth observation on geostationary orbit. The implementation of this technology also faces some challenges, including the configuration of the diffractive primary lens, the development of high diffraction efficiency membrane-based diffractive optical elements, and the correction of the chromatic aberration of the diffractive optical elements. Aiming at the configuration of the diffractive primary lens, the "6+1" petal-type unfold scheme is proposed, which consider the compression ratio, the blocking rate and the development complexity. For high diffraction efficiency membrane-based diffractive optical element, a self-collimating method is proposed. The diffraction efficiency is more than 90 % of the theoretical value. For the chromatic aberration correction problem, an optimization method based on schupmann is proposed to make the imaging spectral bandwidth in visible light band reach 100 nm. The above conclusions have reference significance for the development of ultra-large aperture diffractive optical imaging system.

Object-based assessment of burn severity in diseased forests using high-spatial and high-spectral resolution MASTER airborne imagery

Science.gov (United States)

Chen, Gang; Metz, Margaret R.; Rizzo, David M.; Dillon, Whalen W.; Meentemeyer, Ross K.

2015-04-01

Forest ecosystems are subject to a variety of disturbances with increasing intensities and frequencies, which may permanently change the trajectories of forest recovery and disrupt the ecosystem services provided by trees. Fire and invasive species, especially exotic disease-causing pathogens and insects, are examples of disturbances that together could pose major threats to forest health. This study examines the impacts of fire and exotic disease (sudden oak death) on forests, with an emphasis on the assessment of post-fire burn severity in a forest where trees have experienced three stages of disease progression pre-fire: early-stage (trees retaining dried foliage and fine twigs), middle-stage (trees losing fine crown fuels), and late-stage (trees falling down). The research was conducted by applying Geographic Object-Based Image Analysis (GEOBIA) to MASTER airborne images that were acquired immediately following the fire for rapid assessment and contained both high-spatial (4 m) and high-spectral (50 bands) resolutions. Although GEOBIA has gradually become a standard tool for analyzing high-spatial resolution imagery, high-spectral resolution data (dozens to hundreds of bands) can dramatically reduce computation efficiency in the process of segmentation and object-based variable extraction, leading to complicated variable selection for succeeding modeling. Hence, we also assessed two widely used band reduction algorithms, PCA (principal component analysis) and MNF (minimum noise fraction), for the delineation of image objects and the subsequent performance of burn severity models using either PCA or MNF derived variables. To increase computation efficiency, only the top 5 PCA and MNF and top 10 PCA and MNF components were evaluated, which accounted for 10% and 20% of the total number of the original 50 spectral bands, respectively. Results show that if no band reduction was applied the models developed for the three stages of disease progression had relatively

Field-widened Michelson interferometer for spectral discrimination in high-spectral-resolution lidar: theoretical framework.

Science.gov (United States)

Cheng, Zhongtao; Liu, Dong; Luo, Jing; Yang, Yongying; Zhou, Yudi; Zhang, Yupeng; Duan, Lulin; Su, Lin; Yang, Liming; Shen, Yibing; Wang, Kaiwei; Bai, Jian

2015-05-04

A field-widened Michelson interferometer (FWMI) is developed to act as the spectral discriminator in high-spectral-resolution lidar (HSRL). This realization is motivated by the wide-angle Michelson interferometer (WAMI) which has been used broadly in the atmospheric wind and temperature detection. This paper describes an independent theoretical framework about the application of the FWMI in HSRL for the first time. In the framework, the operation principles and application requirements of the FWMI are discussed in comparison with that of the WAMI. Theoretical foundations for designing this type of interferometer are introduced based on these comparisons. Moreover, a general performance estimation model for the FWMI is established, which can provide common guidelines for the performance budget and evaluation of the FWMI in the both design and operation stages. Examples incorporating many practical imperfections or conditions that may degrade the performance of the FWMI are given to illustrate the implementation of the modeling. This theoretical framework presents a complete and powerful tool for solving most of theoretical or engineering problems encountered in the FWMI application, including the designing, parameter calibration, prior performance budget, posterior performance estimation, and so on. It will be a valuable contribution to the lidar community to develop a new generation of HSRLs based on the FWMI spectroscopic filter.

Field-widened Michelson interferometer for spectral discrimination in high-spectral-resolution lidar: practical development.

Science.gov (United States)

Cheng, Zhongtao; Liu, Dong; Zhang, Yupeng; Yang, Yongying; Zhou, Yudi; Luo, Jing; Bai, Jian; Shen, Yibing; Wang, Kaiwei; Liu, Chong; Su, Lin; Yang, Liming

2016-04-04

A field-widened Michelson interferometer (FWMI), which is intended as the spectroscopic discriminator in ground-based high-spectral-resolution lidar (HSRL) for atmospheric aerosol detection, is described in this paper. The structure, specifications and design of the developed prototype FWMI are introduced, and an experimental approach is proposed to optimize the FWMI assembly and evaluate its comprehensive characteristic simultaneously. Experimental results show that, after optimization process, the peak-to-valley (PV) value and root-mean-square (RMS) value of measured OPD variation for the FWMI are 0.04λ and 0.008λ respectively among the half divergent angle range of 1.5 degree. Through an active locking technique, the frequency of the FWMI can be locked to the laser transmitter with accuracy of 27 MHz for more than one hour. The practical spectral discrimination ratio (SDR) for the developed FWMI is evaluated to be larger than 86 if the divergent angle of incident beam is smaller than 0.5 degree. All these results demonstrate the great potential of the developed FWMI as the spectroscopic discriminator for HSRLs, as well as the feasibility of the proposed design and optimization process. This paper is expected to provide a good entrance for the lidar community in future HSRL developments using the FWMI technique.

Flight Test Results From the Ultra High Resolution, Electro-Optical Framing Camera Containing a 9216 by 9216 Pixel, Wafer Scale, Focal Plane Array

National Research Council Canada - National Science Library

Mathews, Bruce; Zwicker, Theodore

1999-01-01

The details of the fabrication and results of laboratory testing of the Ultra High Resolution Framing Camera containing onchip forward image motion compensation were presented to the SPIE at Airborne...

High-resolution X-ray crystal structure of bovine H-protein using the high-pressure cryocooling method

International Nuclear Information System (INIS)

Higashiura, Akifumi; Ohta, Kazunori; Masaki, Mika; Sato, Masaru; Inaka, Koji; Tanaka, Hiroaki; Nakagawa, Atsushi

2013-01-01

Using the high-pressure cryocooling method, the high-resolution X-ray crystal structure of bovine H-protein was determined at 0.86 Å resolution. This is the first ultra-high-resolution structure obtained from a high-pressure cryocooled crystal. Recently, many technical improvements in macromolecular X-ray crystallography have increased the number of structures deposited in the Protein Data Bank and improved the resolution limit of protein structures. Almost all high-resolution structures have been determined using a synchrotron radiation source in conjunction with cryocooling techniques, which are required in order to minimize radiation damage. However, optimization of cryoprotectant conditions is a time-consuming and difficult step. To overcome this problem, the high-pressure cryocooling method was developed (Kim et al., 2005 ▶) and successfully applied to many protein-structure analyses. In this report, using the high-pressure cryocooling method, the X-ray crystal structure of bovine H-protein was determined at 0.86 Å resolution. Structural comparisons between high- and ambient-pressure cryocooled crystals at ultra-high resolution illustrate the versatility of this technique. This is the first ultra-high-resolution X-ray structure obtained using the high-pressure cryocooling method

Ultra-high resolution water window x ray microscope optics design and analysis

Science.gov (United States)

Shealy, David L.; Wang, C.

1993-01-01

This project has been focused on the design and analysis of an ultra-high resolution water window soft-x-ray microscope. These activities have been accomplished by completing two tasks contained in the statement of work of this contract. The new results from this work confirm: (1) that in order to achieve resolutions greater than three times the wavelength of the incident radiation, it will be necessary to use spherical mirror surfaces and to use graded multilayer coatings on the secondary in order to accommodate the large variations of the angle of incidence over the secondary when operating the microscope at numerical apertures of 0.35 or greater; (2) that surface contour errors will have a significant effect on the optical performance of the microscope and must be controlled to a peak-to-valley variation of 50-100 A and a frequency of 8 periods over the surface of a mirror; and (3) that tolerance analysis of the spherical Schwarzschild microscope has been shown that the water window operations will require 2-3 times tighter tolerances to achieve a similar performance of operations with 130 A radiation. These results have been included in a manuscript included in the appendix.

Multi-application inter-tile synchronization on ultra-high-resolution display walls

KAUST Repository

Nam, Sungwon

2010-01-01

Ultra-high-resolution tiled-display walls are typically driven by a cluster of computers. Each computer may drive one or more displays. Synchronization between the computers is necessary to ensure that animated imagery displayed on the wall appears seamless. Most tiled-display middleware systems are designed around the assumption that only a single application instance is running in the tiled display at a time. Therefore synchronization can be achieved with a simple solution such as a networked barrier. When a tiled display has to support multiple applications at the same time, however, the simple networked barrier approach does not scale. In this paper we propose and experimentally validate two synchronization algorithms to achieve low-latency, intertile synchronization for multiple applications with independently varying frame rates. The two-phase algorithm is more generally applicable to various highresolution tiled display systems. The one-phase algorithm provides superior results but requires support for the Network Time Protocol and is more CPU-intensive. Copyright 2010 ACM.

Spectrally selective molecular doped solids: spectroscopy, photophysics and their application to ultrafast optical pulse processing

International Nuclear Information System (INIS)

Galaup, Jean-Pierre

2005-01-01

The persistent spectral hole-burning (PSHB) phenomenon observed in molecular doped polymers cooled down to liquid helium temperatures allows the engraving of spectral structures in the inhomogeneous absorption profile of the material. This phenomenon known since 1974 has became a fruitful field for the study of the intimacy of complex molecular systems in the solid state, revealing high-resolution spectroscopy, photophysics, photochemistry and dynamics of molecular doped amorphous media, organic as well as inorganic. A PSHB molecular doped solid can be programmed in spectral domain and therefore, it can be converted in an optical processor capable to achieve user-defined optical functions. Some aspects of this field are illustrated in the present paper. An application is presented where a naphthalocyanine doped polymer film is used in a demonstrative experiment to prove that temporal aberration free re-compression of ultra-short light pulses is feasible. Perspectives for the coherent control of light fields or photochemical processes are also evoked

CGLXTouch: A multi-user multi-touch approach for ultra-high-resolution collaborative workspaces

KAUST Repository

Ponto, Kevin

2011-06-01

This paper presents an approach for empowering collaborative workspaces through ultra-high resolution tiled display environments concurrently interfaced with multiple multi-touch devices. Multi-touch table devices are supported along with portable multi-touch tablet and phone devices, which can be added to and removed from the system on the fly. Events from these devices are tagged with a device identifier and are synchronized with the distributed display environment, enabling multi-user support. As many portable devices are not equipped to render content directly, a remotely scene is streamed in. The presented approach scales for large numbers of devices, providing access to a multitude of hands-on techniques for collaborative data analysis. © 2011 Elsevier B.V. All rights reserved.

Oil spill model coupled to an ultra-high-resolution circulation model: implementation for the Adriatic Sea

Science.gov (United States)

Korotenko, K.

2003-04-01

An ultra-high-resolution version of DieCAST was adjusted for the Adriatic Sea and coupled with an oil spill model. Hydrodynamic module was developed on base of th low dissipative, four-order-accuracy version DieCAST with the resolution of ~2km. The oil spill model was developed on base of particle tracking technique The effect of evaporation is modeled with an original method developed on the base of the pseudo-component approach. A special dialog interface of this hybrid system allowing direct coupling to meteorlogical data collection systems or/and meteorological models. Experiments with hypothetic oil spill are analyzed for the Northern Adriatic Sea. Results (animations) of mesoscale circulation and oil slick modeling are presented at wabsite http://thayer.dartmouth.edu/~cushman/adriatic/movies/

Sub-GHz-resolution C-band Nyquist-filtering interleaver on a high-index-contrast photonic integrated circuit.

Science.gov (United States)

Zhuang, Leimeng; Zhu, Chen; Corcoran, Bill; Burla, Maurizio; Roeloffzen, Chris G H; Leinse, Arne; Schröder, Jochen; Lowery, Arthur J

2016-03-21

Modern optical communications rely on high-resolution, high-bandwidth filtering to maximize the data-carrying capacity of fiber-optic networks. Such filtering typically requires high-speed, power-hungry digital processes in the electrical domain. Passive optical filters currently provide high bandwidths with low power consumption, but at the expense of resolution. Here, we present a passive filter chip that functions as an optical Nyquist-filtering interleaver featuring sub-GHz resolution and a near-rectangular passband with 8% roll-off. This performance is highly promising for high-spectral-efficiency Nyquist wavelength division multiplexed (N-WDM) optical super-channels. The chip provides a simple two-ring-resonator-assisted Mach-Zehnder interferometer, which has a sub-cm2 footprint owing to the high-index-contrast Si3N4/SiO2 waveguide, while manifests low wavelength-dependency enabling C-band (> 4 THz) coverage with more than 160 effective free spectral ranges of 25 GHz. This device is anticipated to be a critical building block for spectrally-efficient, chip-scale transceivers and ROADMs for N-WDM super-channels in next-generation optical communication networks.

Ultra-high resolution C-Arm CT arthrography of the wrist: Radiation dose and image quality compared to conventional multidetector computed tomography

Energy Technology Data Exchange (ETDEWEB)

Werncke, Thomas, E-mail: Werncke.Thomas@mh-hannover.de [Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover (Germany); Sonnow, Lena; Meyer, Bernhard C. [Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover (Germany); Lüpke, Matthias [University of Veterinary Medicine Hannover, Institute for General Radiology and Medical Physics, Bischofsholer Damm 15, 30173 Hannover (Germany); Hinrichs, Jan; Wacker, Frank K.; Falck, Christian von [Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover (Germany)

2017-04-15

Objective: Objective of this phantom and cadaveric study was to compare the effective radiation dose (ED) and image quality (IQ) between C-arm computed tomography (CACT) using an ultra-high resolution 1 × 1 binning with a standard 16-slice CT (MDCT) arthrography of the wrist. Methods: ED was determined with thermoluminescence dosimetry using an anthropomorphic phantom and different patient positions. Imaging was conducted in 10 human cadaveric wrists after tri-compartmental injection of diluted iodinated contrast material and a wire phantom. IQ of MDCT was compared with CACT reconstructed with a soft (CACT1) and sharp (CACT2) kernel. High and low contrast resolution was determined. Three radiologists assessed IQ of wrist structures and occurrence of image artifacts using a 5-point Likert scale. Results: ED of MDCT was comparable to standard CACT (4.3 μSv/3.7 μSv). High contrast resolution was best for CACT2, decreased to CACT1 and MDCT. Low contrast resolution increased between CACT2 and MDCT (P < 0.001). IQ was best for CACT2 (1.3 ± 0.5), decreased to CACT1 (1.9 ± 0.6) and MDCT (3.5 ± 0.6). Non-compromising artifacts were only reported for CACT. Conclusions: The results of this phantom and cadaveric study indicate that ultra-high resolution C-Arm CT arthrography of the wrist bears the potential to outperform MDCT arthrography in terms of image quality and workflow at the cost of mildly increasing image artifacts while radiation dose to the patient is comparably low for both, MDCT and C-Arm CT.

A vision for an ultra-high resolution integrated water cycle observation and prediction system

Science.gov (United States)

Houser, P. R.

2013-05-01

Society's welfare, progress, and sustainable economic growth—and life itself—depend on the abundance and vigorous cycling and replenishing of water throughout the global environment. The water cycle operates on a continuum of time and space scales and exchanges large amounts of energy as water undergoes phase changes and is moved from one part of the Earth system to another. We must move toward an integrated observation and prediction paradigm that addresses broad local-to-global science and application issues by realizing synergies associated with multiple, coordinated observations and prediction systems. A central challenge of a future water and energy cycle observation strategy is to progress from single variable water-cycle instruments to multivariable integrated instruments in electromagnetic-band families. The microwave range in the electromagnetic spectrum is ideally suited for sensing the state and abundance of water because of water's dielectric properties. Eventually, a dedicated high-resolution water-cycle microwave-based satellite mission may be possible based on large-aperture antenna technology that can harvest the synergy that would be afforded by simultaneous multichannel active and passive microwave measurements. A partial demonstration of these ideas can even be realized with existing microwave satellite observations to support advanced multivariate retrieval methods that can exploit the totality of the microwave spectral information. The simultaneous multichannel active and passive microwave retrieval would allow improved-accuracy retrievals that are not possible with isolated measurements. Furthermore, the simultaneous monitoring of several of the land, atmospheric, oceanic, and cryospheric states brings synergies that will substantially enhance understanding of the global water and energy cycle as a system. The multichannel approach also affords advantages to some constituent retrievals—for instance, simultaneous retrieval of vegetation

General spectral flow formula for fixed maximal domain

DEFF Research Database (Denmark)

Booss-Bavnbek, Bernhelm; Zhu, Chaofeng

2005-01-01

and symplectic analysis and give a full (and surprisingly short) proof of our General Spectral Flow Formula for the case of fixed maximal domain. As a side result, we establish local stability of weak inner unique continuation property (UCP) and explain its role for parameter dependent spectral theory....... of the resulting continuous family of (unbounded) self-adjoint Fredholm operators in terms of the Maslov index of two related curves of Lagrangian spaces. One curve is given by the varying domains, the other by the Cauchy data spaces. We provide rigorous definitions of the underlying concepts of spectral theory...

Dynamic frequency-domain interferometer for absolute distance measurements with high resolution

International Nuclear Information System (INIS)

Weng, Jidong; Liu, Shenggang; Ma, Heli; Tao, Tianjiong; Wang, Xiang; Liu, Cangli; Tan, Hua

2014-01-01

A unique dynamic frequency-domain interferometer for absolute distance measurement has been developed recently. This paper presents the working principle of the new interferometric system, which uses a photonic crystal fiber to transmit the wide-spectrum light beams and a high-speed streak camera or frame camera to record the interference stripes. Preliminary measurements of harmonic vibrations of a speaker, driven by a radio, and the changes in the tip clearance of a rotating gear wheel show that this new type of interferometer has the ability to perform absolute distance measurements both with high time- and distance-resolution

Dynamic frequency-domain interferometer for absolute distance measurements with high resolution

Science.gov (United States)

Weng, Jidong; Liu, Shenggang; Ma, Heli; Tao, Tianjiong; Wang, Xiang; Liu, Cangli; Tan, Hua

2014-11-01

A unique dynamic frequency-domain interferometer for absolute distance measurement has been developed recently. This paper presents the working principle of the new interferometric system, which uses a photonic crystal fiber to transmit the wide-spectrum light beams and a high-speed streak camera or frame camera to record the interference stripes. Preliminary measurements of harmonic vibrations of a speaker, driven by a radio, and the changes in the tip clearance of a rotating gear wheel show that this new type of interferometer has the ability to perform absolute distance measurements both with high time- and distance-resolution.

Analysis of stationary fuel cell dynamic ramping capabilities and ultra capacitor energy storage using high resolution demand data

Science.gov (United States)

Meacham, James R.; Jabbari, Faryar; Brouwer, Jacob; Mauzey, Josh L.; Samuelsen, G. Scott

Current high temperature fuel cell (HTFC) systems used for stationary power applications (in the 200-300 kW size range) have very limited dynamic load following capability or are simply base load devices. Considering the economics of existing electric utility rate structures, there is little incentive to increase HTFC ramping capability beyond 1 kWs -1 (0.4% s -1). However, in order to ease concerns about grid instabilities from utility companies and increase market adoption, HTFC systems will have to increase their ramping abilities, and will likely have to incorporate electrical energy storage (EES). Because batteries have low power densities and limited lifetimes in highly cyclic applications, ultra capacitors may be the EES medium of choice. The current analyses show that, because ultra capacitors have a very low energy storage density, their integration with HTFC systems may not be feasible unless the fuel cell has a ramp rate approaching 10 kWs -1 (4% s -1) when using a worst-case design analysis. This requirement for fast dynamic load response characteristics can be reduced to 1 kWs -1 by utilizing high resolution demand data to properly size ultra capacitor systems and through demand management techniques that reduce load volatility.

High-resolution spectral analysis of light from neutral beams and ion source plasmas

International Nuclear Information System (INIS)

McNeill, D.H.; Kim, J.

1980-05-01

The spectral distributions of Balmer alpha emission from 7- and 22-cm-diam neutral hydrogen beams have been measured with a Fabry-Perot interferometer to obtain information on the beam energy, divergence, and species composition. Results of these measurements are compared with other data on the beam properties to evaluate high-resolution spectroscopy as a beam diagnostic technique. Measurements on ion source plasmas and on beam-produced background plasmas yield average neutral atom energies of approximately 0.3 and 2.5 eV, respectively

High resolution separations of charge variants and disulfide isomers of monoclonal antibodies and antibody drug conjugates using ultra-high voltage capillary electrophoresis with high electric field strength.

Science.gov (United States)

Henley, W Hampton; He, Yan; Mellors, J Scott; Batz, Nicholas G; Ramsey, J Michael; Jorgenson, James W

2017-11-10

Ultra-high voltage capillary electrophoresis with high electric field strength has been applied to the separation of the charge variants, drug conjugates, and disulfide isomers of monoclonal antibodies. Samples composed of many closely related species are difficult to resolve and quantify using traditional analytical instrumentation. High performance instrumentation can often save considerable time and effort otherwise spent on extensive method development. Ideally, the resolution obtained for a given CE buffer system scales with the square root of the applied voltage. Currently available commercial CE instrumentation is limited to an applied voltage of approximately 30kV and a maximum electric field strength of 1kV/cm due to design limitations. The instrumentation described here is capable of safely applying potentials of at least 120kV with electric field strengths over 2000V/cm, potentially doubling the resolution of the best conventional CE buffer/capillary systems while decreasing analysis time in some applications. Separations of these complex mixtures using this new instrumentation demonstrate the potential of ultra-high voltage CE to identify the presence of previously unresolved components and to reduce analysis time for complex mixtures of antibody variants and drug conjugates. Copyright © 2017 Elsevier B.V. All rights reserved.

Temperature-sensitive gating of hCx26: high-resolution Raman spectroscopy sheds light on conformational changes.

Science.gov (United States)

Kniggendorf, Ann-Kathrin; Meinhardt-Wollweber, Merve; Yuan, Xiaogang; Roth, Bernhard; Seifert, Astrid; Fertig, Niels; Zeilinger, Carsten

2014-07-01

The temperature-sensitive gating of human Connexin 26 (hCx26) was analyzed with confocal Raman microscopy. High-resolution Raman spectra covering the spectral range between 400 and 1500 rel. cm(-1) with a spectral resolution of 1 cm(-1) were fully annotated, revealing notable differences between the spectrum recorded from solubilized hCx26 in Ca(2+)-buffered POPC at 10°C and any other set of protein conditions (temperature, Ca(2+) presence, POPC presence). Spectral components originating from specific amino acids show that the TM1/EL1 parahelix and probably the TM4 trans-membrane helix and the plug domain are involved in the gating process responsible for fully closing the hemichannel.

Spectral domain optical coherence tomography imaging of spectacular ecdysis in the royal python (Python regius).

Science.gov (United States)

Tusler, Charlotte A; Maggs, David J; Kass, Philip H; Paul-Murphy, Joanne R; Schwab, Ivan R; Murphy, Christopher J

2015-01-01

To describe using spectral domain optical coherence tomography (SD-OCT), digital slit-lamp biomicroscopy, and external photography, changes in the ophidian cuticle, spectacle, and cornea during ecdysis. Four normal royal pythons (Python regius). Snakes were assessed once daily throughout a complete shed cycle using nasal, axial, and temporal SD-OCT images, digital slit-lamp biomicroscopy, and external photography. Spectral domain optical coherence tomography (SD-OCT) images reliably showed the spectacular cuticle and stroma, subcuticular space (SCS), cornea, anterior chamber, iris, and Schlemm's canal. When visible, the subspectacular space (SSS) was more distended peripherally than axially. Ocular surface changes throughout ecdysis were relatively conserved among snakes at all three regions imaged. From baseline (7 days following completion of a full cycle), the spectacle gradually thickened before separating into superficial cuticular and deep, hyper-reflective stromal components, thereby creating the SCS. During spectacular separation, the stroma regained original reflectivity, and multiple hyper-reflective foci (likely fragments from the cuticular-stromal interface) were noted within the SCS. The cornea was relatively unchanged in character or thickness throughout all stages of ecdysis. Slit-lamp images did not permit observation of these changes. Spectral domain optical coherence tomography (SD-OCT) provided excellent high-resolution images of the snake anterior segment, and especially the cuticle, spectacle, and cornea of manually restrained normal snakes at all stages of ecdysis and warrants investigation in snakes with anterior segment disease. The peripheral spectacle may be the preferred entry point for diagnostic or therapeutic injections into the SSS and for initiating spectacular surgery. © 2014 American College of Veterinary Ophthalmologists.

High-resolution quantization based on soliton self-frequency shift and spectral compression in a bi-directional comb-fiber architecture

Science.gov (United States)

Zhang, Xuyan; Zhang, Zhiyao; Wang, Shubing; Liang, Dong; Li, Heping; Liu, Yong

2018-03-01

We propose and demonstrate an approach that can achieve high-resolution quantization by employing soliton self-frequency shift and spectral compression. Our approach is based on a bi-directional comb-fiber architecture which is composed of a Sagnac-loop-based mirror and a comb-like combination of N sections of interleaved single-mode fibers and high nonlinear fibers. The Sagnac-loop-based mirror placed at the terminal of a bus line reflects the optical pulses back to the bus line to achieve additional N-stage spectral compression, thus single-stage soliton self-frequency shift (SSFS) and (2 N - 1)-stage spectral compression are realized in the bi-directional scheme. The fiber length in the architecture is numerically optimized, and the proposed quantization scheme is evaluated by both simulation and experiment in the case of N = 2. In the experiment, a quantization resolution of 6.2 bits is obtained, which is 1.2-bit higher than that of its uni-directional counterpart.

A high resolution solar atlas for fluorescence calculations

Science.gov (United States)

Hearn, M. F.; Ohlmacher, J. T.; Schleicher, D. G.

1983-01-01

The characteristics required of a solar atlas to be used for studying the fluorescence process in comets are examined. Several sources of low resolution data were combined to provide an absolutely calibrated spectrum from 2250 A to 7000A. Three different sources of high resolution data were also used to cover this same spectral range. The low resolution data were then used to put each high resolution spectrum on an absolute scale. The three high resolution spectra were then combined in their overlap regions to produce a single, absolutely calibrated high resolution spectrum over the entire spectral range.

Ultra-high field MRI: Advancing systems neuroscience towards mesoscopic human brain function

NARCIS (Netherlands)

Dumoulin, Serge O; Fracasso, A.; Van der Zwaag, W.; Siero, Jeroen C W; Petridou, Natalia

2018-01-01

Human MRI scanners at ultra-high magnetic field strengths of 7 T and higher are increasingly available to the neuroscience community. A key advantage brought by ultra-high field MRI is the possibility to increase the spatial resolution at which data is acquired, with little reduction in image

General spectral flow formula for fixed maximal domain

DEFF Research Database (Denmark)

Booss-Bavnbek, Bernhelm; Zhu, Chaofeng

2005-01-01

of the resulting continuous family of (unbounded) self-adjoint Fredholm operators in terms of the Maslov index of two related curves of Lagrangian spaces. One curve is given by the varying domains, the other by the Cauchy data spaces. We provide rigorous definitions of the underlying concepts of spectral theory......We consider a continuous curve of linear elliptic formally self-adjoint differential operators of first order with smooth coefficients over a compact Riemannian manifold with boundary together with a continuous curve of global elliptic boundary value problems. We express the spectral flow...... and symplectic analysis and give a full (and surprisingly short) proof of our General Spectral Flow Formula for the case of fixed maximal domain. As a side result, we establish local stability of weak inner unique continuation property (UCP) and explain its role for parameter dependent spectral theory....

The evolution of extreme precipitations in high resolution scenarios over France

Science.gov (United States)

Colin, J.; Déqué, M.; Somot, S.

2009-09-01

Over the past years, improving the modelling of extreme events and their variability at climatic time scales has become one of the challenging issue raised in the regional climate research field. This study shows the results of a high resolution (12 km) scenario run over France with the limited area model (LAM) ALADIN-Climat, regarding the representation of extreme precipitations. The runs were conducted in the framework of the ANR-SCAMPEI national project on high resolution scenarios over French mountains. As a first step, we attempt to quantify one of the uncertainties implied by the use of LAM : the size of the area on which the model is run. In particular, we address the issue of whether a relatively small domain allows the model to create its small scale process. Indeed, high resolution scenarios cannot be run on large domains because of the computation time. Therefore one needs to answer this preliminary question before producing and analyzing such scenarios. To do so, we worked in the framework of a « big brother » experiment. We performed a 23-year long global simulation in present-day climate (1979-2001) with the ARPEGE-Climat GCM, at a resolution of approximately 50 km over Europe (stretched grid). This first simulation, named ARP50, constitutes the « big brother » reference of our experiment. It has been validated in comparison with the CRU climatology. Then we filtered the short waves (up to 200 km) from ARP50 in order to obtain the equivalent of coarse resolution lateral boundary conditions (LBC). We have carried out three ALADIN-Climat simulations at a 50 km resolution with these LBC, using different configurations of the model : * FRA50, run over a small domain (2000 x 2000 km, centered over France), * EUR50, run over a larger domain (5000 x 5000 km, centered over France as well), * EUR50-SN, run over the large domain (using spectral nudging). Considering the facts that ARPEGE-Climat and ALADIN-Climat models share the same physics and dynamics

Ultra-High Density Spectral Storage Materials

National Research Council Canada - National Science Library

Hasan, Zameer U

2002-01-01

.... Being atomic scale storage, spectral storage has the potential of providing orders of magnitude denser memories than present day memories that depend on the hulk properties of the storage medium...

kspectrum: an open-source code for high-resolution molecular absorption spectra production

International Nuclear Information System (INIS)

Eymet, V.; Coustet, C.; Piaud, B.

2016-01-01

We present the kspectrum, scientific code that produces high-resolution synthetic absorption spectra from public molecular transition parameters databases. This code was originally required by the atmospheric and astrophysics communities, and its evolution is now driven by new scientific projects among the user community. Since it was designed without any optimization that would be specific to any particular application field, its use could also be extended to other domains. kspectrum produces spectral data that can subsequently be used either for high-resolution radiative transfer simulations, or for producing statistic spectral model parameters using additional tools. This is a open project that aims at providing an up-to-date tool that takes advantage of modern computational hardware and recent parallelization libraries. It is currently provided by Méso-Star (http://www.meso-star.com) under the CeCILL license, and benefits from regular updates and improvements. (paper)

Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing

Science.gov (United States)

Yaqoob, Zahid; Choi, Wonshik; Oh, Seungeun; Lue, Niyom; Park, Yongkeun; Fang-Yen, Christopher; Dasari, Ramachandra R.; Badizadegan, Kamran; Feld, Michael S.

2010-01-01

We report a quantitative phase microscope based on spectral domain optical coherence tomography and line-field illumination. The line illumination allows self phase-referencing method to reject common-mode phase noise. The quantitative phase microscope also features a separate reference arm, permitting the use of high numerical aperture (NA > 1) microscope objectives for high resolution phase measurement at multiple points along the line of illumination. We demonstrate that the path-length sensitivity of the instrument can be as good as 41 pm/Hz, which makes it suitable for nanometer scale study of cell motility. We present the detection of natural motions of cell surface and two-dimensional surface profiling of a HeLa cell. PMID:19550464

ASIC-enabled High Resolution Optical Time Domain Reflectometer

Science.gov (United States)

Skendzic, Sandra

Fiber optics has become the preferred technology in communication systems because of what it has to offer: high data transmission rates, immunity to electromagnetic interference, and lightweight, flexible cables. An optical time domain reflectometer (OTDR) provides a convenient method of locating and diagnosing faults (e.g. break in a fiber) along a fiber that can obstruct crucial optical pathways. Both the ability to resolve the precise location of the fault and distinguish between two discrete, closely spaced faults are figures of merit. This thesis presents an implementation of a high resolution OTDR through the use of a compact and programmable ASIC (application specific integrated circuit). The integration of many essential OTDR functions on a single chip is advantageous over existing commercial instruments because it enables small, lightweight packaging, and offers low power and cost efficiency. Furthermore, its compactness presents the option of placing multiple ASICs in parallel, which can conceivably ease the characterization of densely populated fiber optic networks. The OTDR ASIC consists of a tunable clock, pattern generator, precise timer, electrical receiver, and signal sampling circuit. During OTDR operation, the chip generates narrow electrical pulse, which can then be converted to optical format when coupled with an external laser diode driver. The ASIC also works with an external photodetector to measure the timing and amplitude of optical reflections in a fiber. It has a 1 cm sampling resolution, which allows for a 2 cm spatial resolution. While this OTDR ASIC has been previously demonstrated for multimode fiber fault diagnostics, this thesis focuses on extending its functionality to single mode fiber. To validate this novel approach to OTDR, this thesis is divided into five chapters: (1) introduction, (2) implementation, (3), performance of ASIC-based OTDR, (4) exploration in optical pre-amplification with a semiconductor optical amplifier, and

Extreme ultra-violet movie camera for imaging microsecond time scale magnetic reconnection

International Nuclear Information System (INIS)

Chai, Kil-Byoung; Bellan, Paul M.

2013-01-01

An ultra-fast extreme ultra-violet (EUV) movie camera has been developed for imaging magnetic reconnection in the Caltech spheromak/astrophysical jet experiment. The camera consists of a broadband Mo:Si multilayer mirror, a fast decaying YAG:Ce scintillator, a visible light block, and a high-speed visible light CCD camera. The camera can capture EUV images as fast as 3.3 × 10 6 frames per second with 0.5 cm spatial resolution. The spectral range is from 20 eV to 60 eV. EUV images reveal strong, transient, highly localized bursts of EUV radiation when magnetic reconnection occurs

Extreme ultra-violet movie camera for imaging microsecond time scale magnetic reconnection

Energy Technology Data Exchange (ETDEWEB)

Chai, Kil-Byoung; Bellan, Paul M. [Applied Physics, Caltech, 1200 E. California Boulevard, Pasadena, California 91125 (United States)

2013-12-15

An ultra-fast extreme ultra-violet (EUV) movie camera has been developed for imaging magnetic reconnection in the Caltech spheromak/astrophysical jet experiment. The camera consists of a broadband Mo:Si multilayer mirror, a fast decaying YAG:Ce scintillator, a visible light block, and a high-speed visible light CCD camera. The camera can capture EUV images as fast as 3.3 × 10{sup 6} frames per second with 0.5 cm spatial resolution. The spectral range is from 20 eV to 60 eV. EUV images reveal strong, transient, highly localized bursts of EUV radiation when magnetic reconnection occurs.

System analysis of a tilted field-widened Michelson interferometer for high spectral resolution lidar.

Science.gov (United States)

Liu, Dong; Hostetler, Chris; Miller, Ian; Cook, Anthony; Hair, Johnathan

2012-01-16

High spectral resolution lidars (HSRLs) have shown great value in aircraft aerosol remote sensing application and are planned for future satellite missions. A compact, robust, quasi-monolithic tilted field-widened Michelson interferometer is being developed as the spectral discrimination filter for an second-generation HSRL(HSRL-2) at NASA Langley Research Center. The Michelson interferometer consists of a cubic beam splitter, a solid arm and an air arm. Piezo stacks connect the air arm mirror to the body of the interferometer and can tune the interferometer within a small range. The whole interferometer is tilted so that the standard Michelson output and the reflected complementary output can both be obtained. In this paper, the transmission ratio is proposed to evaluate the performance of the spectral filter for HSRL. The transmission ratios over different types of system imperfections, such as cumulative wavefront error, locking error, reflectance of the beam splitter and anti-reflection coatings, system tilt, and depolarization angle are analyzed. The requirements of each imperfection for good interferometer performance are obtained.

Evaluating the capabilities of vegetation spectral indices on chlorophyll content estimation at Sentinel-2 spectral resolutions

Science.gov (United States)

Sun, Qi; Jiao, Quanjun; Dai, Huayang

2018-03-01

Chlorophyll is an important pigment in green plants for photosynthesis and obtaining the energy for growth and development. The rapid, nondestructive and accurate estimation of chlorophyll content is significant for understanding the crops growth, monitoring the disease and insect, and assessing the yield of crops. Sentinel-2 equipped with the Multi-Spectral Instrument (MSI), which will provide images with high spatial, spectral and temporal resolution. It covers the VNIR/SWIR spectral region in 13 bands and incorporates two new spectral bands in the red-edge region and a spatial resolution of 20nm, which can be used to derive vegetation indices using red-edge bands. In this paper, we will focus on assessing the potential of vegetation spectral indices for retrieving chlorophyll content from Sentinel-2 at different angles. Subsequently, we used in-situ spectral data and Sentinel-2 data to test the relationship between VIs and chlorophyll content. The REP, MTCI, CIred-edge, CIgreen, Macc01, TCARI/OSAVI [705,750], NDRE1 and NDRE2 were calculated. NDRE2 index displays a strongly similar result for hyperspectral and simulated Sentinel-2 spectral bands (R2 =0.53, R2 =0.51, for hyperspectral and Sentinel-2, respectively). At different observation angles, NDRE2 has the smallest difference in performance (R2 = 0.51, R2 =0.64, at 0° and 15° , respectively).

A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI

DEFF Research Database (Denmark)

Iglesias, Juan Eugenio; Augustinack, Jean C.; Nguyen, Khoa

2015-01-01

level using ultra-high resolution, ex vivo MRI. Fifteen autopsy samples were scanned at 0.13 mm isotropic resolution (on average) using customized hardware. The images were manually segmented into 13 different hippocampal substructures using a protocol specifically designed for this study; precise...... datasets with different types of MRI contrast. The results show that the atlas and companion segmentation method: 1) can segment T1 and T2 images, as well as their combination, 2) replicate findings on mild cognitive impairment based on high-resolution T2 data, and 3) can discriminate between Alzheimer......'s disease subjects and elderly controls with 88% accuracy in standard resolution (1 mm) T1 data, significantly outperforming the atlas in FreeSurfer version 5.3 (86% accuracy) and classification based on whole hippocampal volume (82% accuracy)....

Geo-oculus: high resolution multi-spectral earth imaging mission from geostationary orbit

Science.gov (United States)

Vaillon, L.; Schull, U.; Knigge, T.; Bevillon, C.

2017-11-01

Geo-Oculus is a GEO-based Earth observation mission studied by Astrium for ESA in 2008-2009 to complement the Sentinel missions, the space component of the GMES (Global Monitoring for Environment & Security). Indeed Earth imaging from geostationary orbit offers new functionalities not covered by existing LEO observation missions, like real-time monitoring and fast revisit capability of any location within the huge area in visibility of the satellite. This high revisit capability is exploited by the Meteosat meteorogical satellites, but with a spatial resolution (500 m nadir for the third generation) far from most of GMES needs (10 to 100 m). To reach such ground resolution from GEO orbit with adequate image quality, large aperture instruments (> 1 m) and high pointing stability (challenges of such missions. To address the requirements from the GMES user community, the Geo-Oculus mission is a combination of routine observations (daily systematic coverage of European coastal waters) with "on-demand" observation for event monitoring (e.g. disasters, fires and oil slicks). The instrument is a large aperture imaging telescope (1.5 m diameter) offering a nadir spatial sampling of 10.5 m (21 m worst case over Europe, below 52.5°N) in a PAN visible channel used for disaster monitoring. The 22 multi-spectral channels have resolutions over Europe ranging from 40 m in UV/VNIR (0.3 to 1 μm) to 750 m in TIR (10-12 μm).

CHEMICAL ABUNDANCES IN FIELD RED GIANTS FROM HIGH-RESOLUTION H-BAND SPECTRA USING THE APOGEE SPECTRAL LINELIST

International Nuclear Information System (INIS)

Smith, Verne V.; Cunha, Katia; Shetrone, Matthew D.; Meszaros, Szabolcs; Allende Prieto, Carlos; Bizyaev, Dmitry; Garcìa Pèrez, Ana; Majewski, Steven R.; Schiavon, Ricardo; Holtzman, Jon; Johnson, Jennifer A.

2013-01-01

High-resolution H-band spectra of five bright field K, M, and MS giants, obtained from the archives of the Kitt Peak National Observatory Fourier transform spectrometer, are analyzed to determine chemical abundances of 16 elements. The abundances were derived via spectrum synthesis using the detailed linelist prepared for the Sloan Digital Sky Survey III Apache Point Galactic Evolution Experiment (APOGEE), which is a high-resolution near-infrared spectroscopic survey to derive detailed chemical abundance distributions and precise radial velocities for 100,000 red giants sampling all Galactic stellar populations. The red giant sample studied here was chosen to probe which chemical elements can be derived reliably from the H-band APOGEE spectral region. These red giants consist of two K-giants (α Boo and μ Leo), two M-giants (β And and δ Oph), and one thermally pulsing asymptotic giant branch (TP-AGB) star of spectral type MS (HD 199799). Measured chemical abundances include the cosmochemically important isotopes 12 C, 13 C, 14 N, and 16 O, along with Mg, Al, Si, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, and Cu. The K and M giants exhibit the abundance signature of the first dredge-up of CN-cycle material, while the TP-AGB star shows clear evidence of the addition of 12 C synthesized during 4 He-burning thermal pulses and subsequent third dredge-up. A comparison of the abundances derived here with published values for these stars reveals consistent results to ∼0.1 dex. The APOGEE spectral region and linelist is thus well suited for probing both Galactic chemical evolution, as well as internal nucleosynthesis and mixing in populations of red giants via high-resolution spectroscopy.

CHEMICAL ABUNDANCES IN FIELD RED GIANTS FROM HIGH-RESOLUTION H-BAND SPECTRA USING THE APOGEE SPECTRAL LINELIST

Energy Technology Data Exchange (ETDEWEB)

Smith, Verne V.; Cunha, Katia [National Optical Astronomy Observatories, Tucson, AZ 85719 (United States); Shetrone, Matthew D. [Department of Astronomy and McDonald Observatory, University of Texas, Austin, TX 78712 (United States); Meszaros, Szabolcs; Allende Prieto, Carlos [Instituto d' Astrofisica de Canarias, E-38205, La Laguna, Tenerife (Spain); Bizyaev, Dmitry [Apache Point Observatory, Sunspot, NM 88349 (United States); Garcia Perez, Ana; Majewski, Steven R. [Department of Astronomy, University of Virginia, Charlottesville, VA 22904 (United States); Schiavon, Ricardo [Astrophysics Research Institute, Liverpool John Moores University, Liverpool L3 5UX (United Kingdom); Holtzman, Jon [Department of Astronomy, New Mexico State University, Las Cruces, NM 88003 (United States); Johnson, Jennifer A., E-mail: vsmith@noao.edu [Department of Astronomy, Ohio State University, Columbus, OH 43210 (United States)

2013-03-01

High-resolution H-band spectra of five bright field K, M, and MS giants, obtained from the archives of the Kitt Peak National Observatory Fourier transform spectrometer, are analyzed to determine chemical abundances of 16 elements. The abundances were derived via spectrum synthesis using the detailed linelist prepared for the Sloan Digital Sky Survey III Apache Point Galactic Evolution Experiment (APOGEE), which is a high-resolution near-infrared spectroscopic survey to derive detailed chemical abundance distributions and precise radial velocities for 100,000 red giants sampling all Galactic stellar populations. The red giant sample studied here was chosen to probe which chemical elements can be derived reliably from the H-band APOGEE spectral region. These red giants consist of two K-giants ({alpha} Boo and {mu} Leo), two M-giants ({beta} And and {delta} Oph), and one thermally pulsing asymptotic giant branch (TP-AGB) star of spectral type MS (HD 199799). Measured chemical abundances include the cosmochemically important isotopes {sup 12}C, {sup 13}C, {sup 14}N, and {sup 16}O, along with Mg, Al, Si, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, and Cu. The K and M giants exhibit the abundance signature of the first dredge-up of CN-cycle material, while the TP-AGB star shows clear evidence of the addition of {sup 12}C synthesized during {sup 4}He-burning thermal pulses and subsequent third dredge-up. A comparison of the abundances derived here with published values for these stars reveals consistent results to {approx}0.1 dex. The APOGEE spectral region and linelist is thus well suited for probing both Galactic chemical evolution, as well as internal nucleosynthesis and mixing in populations of red giants via high-resolution spectroscopy.

Accelerated high-resolution 3D magnetic resonance spectroscopic imaging in the brain At 7 T

International Nuclear Information System (INIS)

Hangel, G.

2015-01-01

With the announcement of the first series of magnetic resonance (MR) scanners with a field strength of 7 Tesla (T) intended for clinical practice, the development of high-performance sequences for higher field strengths has gained importance. Magnetic resonance spectroscopic imaging (MRSI) in the brain currently offers the unique ability to spatially resolve the distribution of multiple metabolites simultaneously. Its big diagnostic potential could be applied to many clinical protocols, for example the assessment of tumour treatment or progress of Multiple Sclerosis. Moving to ultra-high fields like 7 T has the main benefits of increased signal-to-noise ratio (SNR) and improved spectral quality, but brings its own challenges due to stronger field inhomogeneities. Necessary for a robust, flexible and useful MRSI sequence in the brain are high resolutions, shortened measurement times, the possibility for 3D-MRSI and the suppression of spectral contamination by trans-cranial lipids. This thesis addresses these limitations and proposes Hadamard spectroscopic imaging (HSI) as solution for multi-slice MRSI, the application of generalized autocalibrating partially parallel acquisition (GRAPPA) and spiral trajectories for measurement acceleration, non-selective inversion recovery (IR) lipid-suppression as well as combinations of these methods. Further, the optimisation of water suppression for 7 T systems and the acquisition of ultra-high resolution (UHR)-MRSI are discussed. In order to demonstrate the clinical feasibility of these approaches, MRSI measurement results of a glioma patient are presented. The discussion of the obtained results in the context of the state-of-art in 7 T MRSI in the brain, possible future applications as well as potential further improvements of the MRSI sequences conclude this thesis. (author) [de

High Spectral Resolution Observation of the Soft Diffuse X-ray Background in the Direction of the Galactic Anti-Center

Science.gov (United States)

Wulf, Dallas; Eckart, Mega E.; Galeazzi, Massimiliano; Jaeckel, Felix; Kelley, Richard L.; Kilbourne, Caroline A.; McCammon, Dan; Morgan, Kelsey M.; Porter, Frederick S.; Szymkowiak, Andrew E.

2018-01-01

High spectral resolution observations in the soft x-rays are necessary for understanding and modelling the hot component of the interstellar medium and its contribution to the Soft X-ray Background (SXRB). This extended source emission cannot be resolved with most wavelength dispersive spectrometers, making energy dispersive microcalorimeters the ideal choice for these observations. We present here the analysis of the most recent sounding rocket flight of the University of Wisconsin-Madison/Goddard Space Flight Center X-ray Quantum Calorimeter (XQC), a large area silicon thermistor microcalorimeter. This 111 second observation integrates a nearly 1 steradian field of view in the direction of the galactic anti-center (l, b = 165°, -5°) and features ~5 eV spectral resolution below 1 keV. Direct comparison will also be made to the previous, high-latitude observations.

Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats

International Nuclear Information System (INIS)

Crunelle, Cleo L.; Wit, Tim C. de; Bruin, Kora de; Ramakers, Ruud M.; Have, Frans van der; Beekman, Freek J.; Brink, Wim van den; Booij, Jan

2012-01-01

Introduction: Ex vivo storage phosphor imaging rat studies reported increased brain dopamine D 2/3 receptor (DRD 2/3 ) availability following treatment with varenicline, a nicotinergic drug. However, ex vivo studies can only be performed using cross-sectional designs. Small-animal imaging offers the opportunity to perform serial assessments. We evaluated whether high-resolution pinhole single photon emission computed tomography (SPECT) imaging in rats was able to reproduce previous ex vivo findings. Methods: Rats were imaged for baseline striatal DRD 2/3 availability using ultra-high-resolution pinhole SPECT (U-SPECT-II) and [ 123 I]IBZM as a radiotracer, and randomized to varenicline (n=7; 2 mg/kg) or saline (n=7). Following 2 weeks of treatment, a second scan was acquired. Results: Significantly increased striatal DRD 2/3 availability was found following varenicline treatment compared to saline (time⁎treatment effect): posttreatment difference in binding potential between groups corrected for initial baseline differences was 2.039 (P=.022), indicating a large effect size (d=1.48). Conclusions: Ultra-high-resolution pinhole SPECT can be used to assess varenicline-induced changes in DRD 2/3 availability in small laboratory animals over time. Future small-animal studies should include imaging techniques to enable repeated within-subjects measurements and reduce the amount of animals.

Immersion Gratings for Infrared High-resolution Spectroscopy

Science.gov (United States)

Sarugaku, Yuki; Ikeda, Yuji; Kobayashi, Naoto; Kaji, Sayumi; Sukegawa, Takashi; Sugiyama, Shigeru; Nakagawa, Takao; Arasaki, Takayuki; Kondo, Sohei; Nakanishi, Kenshi; Yasui, Chikako; Kawakita, Hideyo

2016-10-01

High-resolution spectroscopy in the infrared wavelength range is essential for observations of minor isotopologues, such as HDO for water, and prebiotic organic molecules like hydrocarbons/P-bearing molecules because numerous vibrational molecular bands (including non-polar molecules) are located in this wavelength range. High spectral resolution enables us to detect weak lines without spectral line confusion. This technique has been widely used in planetary sciences, e.g., cometary coma (H2O, CO, and organic molecules), the martian atmosphere (CH4, CO2, H2O and HDO), and the upper atmosphere of gas giants (H3+ and organic molecules such as C2H6). Spectrographs with higher resolution (and higher sensitivity) still have a potential to provide a plenty of findings. However, because the size of spectrographs scales with the spectral resolution, it is difficult to realize it.Immersion grating (IG), which is a diffraction grating wherein the diffraction surface is immersed in a material with a high refractive index (n > 2), provides n times higher spectral resolution compared to a reflective grating of the same size. Because IG reduces the size of spectrograph to 1/n compared to the spectrograph with the same spectral resolution using a conventional reflective grating, it is widely acknowledged as a key optical device to realize compact spectrographs with high spectral resolution.Recently, we succeeded in fabricating a CdZnTe immersion grating with the theoretically predicted diffraction efficiency by machining process using an ultrahigh-precision five-axis processing machine developed by Canon Inc. Using the same technique, we completed a practical germanium (Ge) immersion grating with both a reflection coating on the grating surface and the an AR coating on the entrance surface. It is noteworthy that the wide wavelength range from 2 to 20 um can be covered by the two immersion gratings.In this paper, we present the performances and the applications of the immersion

Ultra-high efficiency, fast graphene micro-heater on silicon

DEFF Research Database (Denmark)

Yan, Siqi; Zhu, Xiaolong; Frandsen, Lars Hagedorn

2017-01-01

We demonstrate an ultra-high efficiency and fast graphene microheater on silicon photonic crystal waveguide. By taking advantage of slow-light effect, a tuning efficiency of 1.07 nm/mW and power consumption per free spectral range of 3.99 mW. A fast rise and decay times (10% to 90%) of only 750 ns...

Spectral encoded optical label detection for dynamic routing of impulse radio ultra-wideband signals in metro-access networks

DEFF Research Database (Denmark)

Osadchiy, Alexey Vladimirovich; Yu, Xianbin; Yin, Xiaoli

2010-01-01

In this paper we propose and experimentally demonstrate the principle of coherent label detection for dynamic routing of wavelength division multiplexed impulse radio ultra-wideband signals by using four-tone spectral amplitude coded labels.......In this paper we propose and experimentally demonstrate the principle of coherent label detection for dynamic routing of wavelength division multiplexed impulse radio ultra-wideband signals by using four-tone spectral amplitude coded labels....

A New High-Resolution Spectral Approach to Noninvasively Evaluate Wall Deformations in Arteries

Directory of Open Access Journals (Sweden)

Ivonne Bazan

2014-01-01

Full Text Available By locally measuring changes on arterial wall thickness as a function of pressure, the related Young modulus can be evaluated. This physical magnitude has shown to be an important predictive factor for cardiovascular diseases. For evaluating those changes, imaging segmentation or time correlations of ultrasonic echoes, coming from wall interfaces, are usually employed. In this paper, an alternative low-cost technique is proposed to locally evaluate variations on arterial walls, which are dynamically measured with an improved high-resolution calculation of power spectral densities in echo-traces of the wall interfaces, by using a parametric autoregressive processing. Certain wall deformations are finely detected by evaluating the echoes overtones peaks with power spectral estimations that implement Burg and Yule Walker algorithms. Results of this spectral approach are compared with a classical cross-correlation operator, in a tube phantom and “in vitro” carotid tissue. A circulating loop, mimicking heart periods and blood pressure changes, is employed to dynamically inspect each sample with a broadband ultrasonic probe, acquiring multiple A-Scans which are windowed to isolate echo-traces packets coming from distinct walls. Then the new technique and cross-correlation operator are applied to evaluate changing parietal deformations from the detection of displacements registered on the wall faces under periodic regime.

A New High-Resolution Spectral Approach to Noninvasively Evaluate Wall Deformations in Arteries

Science.gov (United States)

Bazan, Ivonne; Negreira, Carlos; Ramos, Antonio; Brum, Javier; Ramirez, Alfredo

2014-01-01

By locally measuring changes on arterial wall thickness as a function of pressure, the related Young modulus can be evaluated. This physical magnitude has shown to be an important predictive factor for cardiovascular diseases. For evaluating those changes, imaging segmentation or time correlations of ultrasonic echoes, coming from wall interfaces, are usually employed. In this paper, an alternative low-cost technique is proposed to locally evaluate variations on arterial walls, which are dynamically measured with an improved high-resolution calculation of power spectral densities in echo-traces of the wall interfaces, by using a parametric autoregressive processing. Certain wall deformations are finely detected by evaluating the echoes overtones peaks with power spectral estimations that implement Burg and Yule Walker algorithms. Results of this spectral approach are compared with a classical cross-correlation operator, in a tube phantom and “in vitro” carotid tissue. A circulating loop, mimicking heart periods and blood pressure changes, is employed to dynamically inspect each sample with a broadband ultrasonic probe, acquiring multiple A-Scans which are windowed to isolate echo-traces packets coming from distinct walls. Then the new technique and cross-correlation operator are applied to evaluate changing parietal deformations from the detection of displacements registered on the wall faces under periodic regime. PMID:24688596

Combined Atmospheric and Ocean Profiling from an Airborne High Spectral Resolution Lidar

Directory of Open Access Journals (Sweden)

Hair Johnathan

2016-01-01

Full Text Available First of its kind combined atmospheric and ocean profile data were collected by the recently upgraded NASA Langley Research Center’s (LaRC High Spectral Resolution Lidar (HSRL-1 during the 17 July – 7 August 2014 Ship-Aircraft Bio-Optical Research Experiment (SABOR. This mission sampled over a region that covered the Gulf of Maine, open-ocean near Bermuda, and coastal waters from Virginia to Rhode Island. The HSRL-1 and the Research Scanning Polarimeter from NASA Goddard Institute for Space Studies collected data onboard the NASA LaRC King Air aircraft and flight operations were closely coordinated with the Research Vessel Endeavor that made in situ ocean optical measurements. The lidar measurements provided profiles of atmospheric backscatter and particulate depolarization at 532nm, 1064nm, and extinction (532nm from approximately 9km altitude. In addition, for the first time HSRL seawater backscatter, depolarization, and diffuse attenuation data at 532nm were collected and compared to both the ship measurements and the Moderate Resolution Imaging Spectrometer (NASA MODIS-Aqua satellite ocean retrievals.

Visual analytics of inherently noisy crowdsourced data on ultra high resolution displays

Science.gov (United States)

Huynh, Andrew; Ponto, Kevin; Lin, Albert Yu-Min; Kuester, Falko

The increasing prevalence of distributed human microtasking, crowdsourcing, has followed the exponential increase in data collection capabilities. The large scale and distributed nature of these microtasks produce overwhelming amounts of information that is inherently noisy due to the nature of human input. Furthermore, these inputs create a constantly changing dataset with additional information added on a daily basis. Methods to quickly visualize, filter, and understand this information over temporal and geospatial constraints is key to the success of crowdsourcing. This paper present novel methods to visually analyze geospatial data collected through crowdsourcing on top of remote sensing satellite imagery. An ultra high resolution tiled display system is used to explore the relationship between human and satellite remote sensing data at scale. A case study is provided that evaluates the presented technique in the context of an archaeological field expedition. A team in the field communicated in real-time with and was guided by researchers in the remote visual analytics laboratory, swiftly sifting through incoming crowdsourced data to identify target locations that were identified as viable archaeological sites.

Feasibility of microwave interferometry and fourier-transform spectrometry for high-spectral-resolution sensing

Energy Technology Data Exchange (ETDEWEB)

Gerstl, S.; Cooke, B.; Jacobson, A.; Love, S.; Zardecki, A.

1996-09-01

This is the final report of a one-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The primary objective of this project was to perform the necessary research and development to determine the feasibility of new ideas that, if successful, could lead to the development of future new programs in high-spectral resolution remote sensing. In active remote sensing systems, the solar illumination of a scene is replaced by a man-made source, preferably a laser beam. However, when laser beams are propagated through a scattering medium, like air, random optical path fluctuations comparable to the optical wavelength are generated giving rise to the speckle effect, which is the most severe perturbation in active remote sensing systems. The limitations introduced by the speckle effect degrade or negate the data interpretation. We sought to introduce better physical models of beam scattering that allow a more realistic simulation environment to be developed that, when applied to experimental data sets, improve their interpretability and increase the information content. Improved beam propagation models require improved knowledge of the spatio-temporal distribution of the scattering and absorbing medium. In the free atmosphere the largest contributor is water vapor in the lower troposphere. We tested the feasibility of using microwave interferometry to measure water-vapor irregularities in the boundary layer. Knowledge of these distributions enable much improved atmospheric correction algorithms for satellite imagery of the earth`s surface to be developed. For hyperspectral active remote sensing systems it is necessary to perform very high-resolution spectral measurements of the reflected laser light. Such measurements are possible with optical interferometers.

Development of a low-cost, 11 µm spectral domain optical coherence tomography surface profilometry prototype

Science.gov (United States)

Suliali, Nyasha J.; Baricholo, Peter; Neethling, Pieter H.; Rohwer, Erich G.

2017-06-01

A spectral-domain Optical Coherence Tomography (OCT) surface profilometry prototype has been developed for the purpose of surface metrology of optical elements. The prototype consists of a light source, spectral interferometer, sample fixture and software currently running on Microsoft® Windows platforms. In this system, a broadband light emitting diode beam is focused into a Michelson interferometer with a plane mirror as its sample fixture. At the interferometer output, spectral interferograms of broadband sources were measured using a Czerny-Turner mount monochromator with a 2048-element complementary metal oxide semiconductor linear array as the detector. The software performs importation and interpolation of interferometer spectra to pre-condition the data for image computation. One dimensional axial OCT images were computed by Fourier transformation of the measured spectra. A first reflection surface profilometry (FRSP) algorithm was then formulated to perform imaging of step-function-surfaced samples. The algorithm re-constructs two dimensional colour-scaled slice images by concatenation of 21 and 13 axial scans to form a 10 mm and 3.0 mm slice respectively. Measured spectral interferograms, computed interference fringe signals and depth reflectivity profiles were comparable to simulations and correlated to displacements of a single reflector linearly translated about the arm null-mismatch point. Surface profile images of a double-step-function-surfaced sample, embedded with inclination and crack detail were plotted with an axial resolution of 11 μm. The surface shape, defects and misalignment relative to the incident beam were detected to the order of a micron, confirming high resolution of the developed system as compared to electro-mechanical surface profilometry techniques.

Online monitoring of printed electronics by Spectral-Domain Optical Coherence Tomography

KAUST Repository

Alarousu, Erkki

2013-03-28

Spectral-Domain Optical Coherence Tomography (SD-OCT) is an optical method capable of 3D imaging of object\\'s internal structure with micron-scale resolution. Modern SD-OCT tools offer the speed capable of online monitoring of printed devices. This paper demonstrates the use of SD-OCT in a simulated roll-to-roll (R2R) process through monitoring some structural properties of moving screen printed interdigitated electrodes. It is shown that structural properties can be resolved for speeds up to ca. 1m/min, which is the first step towards application of this method in real manufacturing processes, including roll-to-roll (R2R) printing.

SWIFTS: on-chip very high spectral resolution spectrometer

Science.gov (United States)

le Coarer, E.; Venancio, L. G.; Kern, P.; Ferrand, J.; Puget, P.; Ayraud, M.; Bonneville, C.; Demonte, B.; Morand, A.; Boussey, J.; Barbier, D.; Blaize, S.; Gonthiez, T.

2017-11-01

The size and the weight of state of the art spectrometers is a serious issue regarding space applications. SWIFTS (Stationary Wave Integrated Fourier Transform Spectrometer) is a new FTS family without any moving part. This very promising technology is an original way to fully sample the Fourier interferogram obtained in a waveguide by either a reflection (SWIFTS Lippmann) or counter-propagative (SWIFTS Gabor) interference phenomenon. The sampling is simultaneously performed the optical path thanks to "nano-detectors" located in the evanescent field of the waveguide. For instance a 1.7cm long waveguide properly associated to the detector achieves directly a resolution of 0.13cm-1 on a few centimetre long instruments. Here, firstly we present the development status of this new kind of spectrometers and the first results obtained with on going development of spectrometer covering simultaneously the visible domain from 400 to 1000 nm like an Echelle spectrometer. Valuable technologies allows one to extend the concept to various wavelength domains. Secondly, we present the results obtained in the frame of an activity funded by the European Space Agency where several potential applications in space missions have been identified and studied.

Spectral Difference in the Image Domain for Large Neighborhoods, a GEOBIA Pre-Processing Step for High Resolution Imagery

Directory of Open Access Journals (Sweden)

Roeland de Kok

2012-08-01

Full Text Available Contrast plays an important role in the visual interpretation of imagery. To mimic visual interpretation and using contrast in a Geographic Object Based Image Analysis (GEOBIA environment, it is useful to consider an analysis for single pixel objects. This should be done before applying homogeneity criteria in the aggregation of pixels for the construction of meaningful image objects. The habit or “best practice” to start GEOBIA with pixel aggregation into homogeneous objects should come with the awareness that feature attributes for single pixels are at risk of becoming less accessible for further analysis. Single pixel contrast with image convolution on close neighborhoods is a standard technique, also applied in edge detection. This study elaborates on the analysis of close as well as much larger neighborhoods inside the GEOBIA domain. The applied calculations are limited to the first segmentation step for single pixel objects in order to produce additional feature attributes for objects of interest to be generated in further aggregation processes. The equation presented functions at a level that is considered an intermediary product in the sequential processing of imagery. The procedure requires intensive processor and memory capacity. The resulting feature attributes highlight not only contrasting pixels (edges but also contrasting areas of local pixel groups. The suggested approach can be extended and becomes useful in classifying artificial areas at national scales using high resolution satellite mosaics.

Highly vibrationally excited O2 molecules in low-pressure inductively-coupled plasmas detected by high sensitivity ultra-broad-band optical absorption spectroscopy

Science.gov (United States)

Foucher, Mickaël; Marinov, Daniil; Carbone, Emile; Chabert, Pascal; Booth, Jean-Paul

2015-08-01

Inductively-coupled plasmas in pure O2 (at pressures of 5-80 mTorr and radiofrequency power up to 500 W) were studied by optical absorption spectroscopy over the spectral range 200-450 nm, showing the presence of highly vibrationally excited O2 molecules (up to vʺ = 18) by Schumann-Runge band absorption. Analysis of the relative band intensities indicates a vibrational temperature up to 10,000 K, but these hot molecules only represent a fraction of the total O2 density. By analysing the (11-0) band at higher spectral resolution the O2 rotational temperature was also determined, and was found to increase with both pressure and power, reaching 900 K at 80 mTorr 500 W. These measurements were achieved using a new high-sensitivity ultra-broad-band absorption spectroscopy setup, based on a laser-plasma light source, achromatic optics and an aberration-corrected spectrograph. This setup allows the measurement of weak broadband absorbances due to a baseline variability lower than 2   ×   10-5 across a spectral range of 250 nm.

Volumetric three-dimensional reconstruction and segmentation of spectral-domain OCT.

Science.gov (United States)

Aaker, Grant D; Gracia, Luis; Myung, Jane S; Borcherding, Vanessa; Banfelder, Jason R; D'Amico, Donald J; Kiss, Szilárd

2011-07-01

Despite advances in optical coherence tomography (OCT), three-dimensional (3D) renderings of OCT images remain limited to scanning consecutive two-dimensional (2D) OCT slices. The authors describe a method of reconstructing 2D OCT data for 3D retinal analysis and visualization in a Computer Assisted Virtual Environment (CAVE). Using customized signal processing software, raw data from 2D slice-based spectral-domain OCT images were rendered into high-resolution 3D images for segmentation and quantification analysis. Reconstructed OCT images were projected onto a four-walled space and viewed through stereoscopic glasses, resulting in a virtual reality perception of the retina. These 3D retinal renderings offer a novel method for segmentation and isolation of volumetric images. The ability to manipulate the images in a virtual reality environment allows visualization of complex spatial relationships that may aid our understanding of retinal pathology. More importantly, these 3D retinal renderings can be viewed, manipulated, and analyzed on traditional 2D monitors independent of the CAVE. Copyright 2011, SLACK Incorporated.

High-resolution X-ray crystal structure of bovine H-protein using the high-pressure cryocooling method.

Science.gov (United States)

Higashiura, Akifumi; Ohta, Kazunori; Masaki, Mika; Sato, Masaru; Inaka, Koji; Tanaka, Hiroaki; Nakagawa, Atsushi

2013-11-01

Recently, many technical improvements in macromolecular X-ray crystallography have increased the number of structures deposited in the Protein Data Bank and improved the resolution limit of protein structures. Almost all high-resolution structures have been determined using a synchrotron radiation source in conjunction with cryocooling techniques, which are required in order to minimize radiation damage. However, optimization of cryoprotectant conditions is a time-consuming and difficult step. To overcome this problem, the high-pressure cryocooling method was developed (Kim et al., 2005) and successfully applied to many protein-structure analyses. In this report, using the high-pressure cryocooling method, the X-ray crystal structure of bovine H-protein was determined at 0.86 Å resolution. Structural comparisons between high- and ambient-pressure cryocooled crystals at ultra-high resolution illustrate the versatility of this technique. This is the first ultra-high-resolution X-ray structure obtained using the high-pressure cryocooling method.

Spectral domain optical coherence tomography findings in tamoxifen retinopathy--a case report.

Science.gov (United States)

Nair, Sandhya Narayanan; Anantharaman, Giridhar; Gopalakrishnan, Mahesh; Vyas, Jyothiprakash

2013-01-01

To report spectral domain optical coherence tomography findings in a case of typical tamoxifen retinopathy. In this observational case report, a patient with tamoxifen retinopathy was imaged with spectral domain optical coherence tomography and fundus auto fluorescence. Spectral domain optical coherence tomography showed numerous hyperreflective spots within the retina, mainly in the inner retinal layers in both the eyes. The external limiting membrane, the Inner Segment-Outer Segment junction, and the photoreceptors were not discernable at the fovea in the right eye. In the left eye, there was foveal atrophy with total loss of photoreceptors. The autofluorescent images showed macular hypofluorescence with foveal hyperfluorescence. Spectral domain optical coherence tomography demonstrated abnormalities in the outer retinal layers in tamoxifen retinopathy. There were also characteristic alterations in the autofluorescence pattern at the macula in tamoxifen retinopathy.

Performance characterization of a pressure-tuned wide-angle Michelson interferometric spectral filter for high spectral resolution lidar

Science.gov (United States)

Seaman, Shane T.; Cook, Anthony L.; Scola, Salvatore J.; Hostetler, Chris A.; Miller, Ian; Welch, Wayne

2015-09-01

High Spectral Resolution Lidar (HSRL) is typically realized using an absorption filter to separate molecular returns from particulate returns. NASA Langley Research Center (LaRC) has designed and built a Pressure-Tuned Wide-Angle Michelson Interferometer (PTWAMI) as an alternate means to separate the two types of atmospheric returns. While absorption filters only work at certain wavelengths and suffer from low photon efficiency due to light absorption, an interferometric spectral filter can be designed for any wavelength and transmits nearly all incident photons. The interferometers developed at LaRC employ an air spacer in one arm, and a solid glass spacer in the other. Field widening is achieved by specific design and selection of the lengths and refractive indices of these two arms. The principal challenge in using such an interferometer as a spectral filter for HSRL aboard aircraft is that variations in glass temperature and air pressure cause changes in the interferometer's optical path difference. Therefore, a tuning mechanism is needed to actively accommodate for these changes. The pressure-tuning mechanism employed here relies on changing the pressure in an enclosed, air-filled arm of the interferometer to change the arm's optical path length. However, tuning using pressure will not adjust for tilt, mirror warpage, or thermally induced wavefront error, so the structural, thermal, and optical behavior of the device must be well understood and optimized in the design and manufacturing process. The PTWAMI has been characterized for particulate transmission ratio, wavefront error, and tilt, and shows acceptable performance for use in an HSRL instrument.

Spectral element method for elastic and acoustic waves in frequency domain

Energy Technology Data Exchange (ETDEWEB)

Shi, Linlin; Zhou, Yuanguo; Wang, Jia-Min; Zhuang, Mingwei [Institute of Electromagnetics and Acoustics, and Department of Electronic Science, Xiamen, 361005 (China); Liu, Na, E-mail: liuna@xmu.edu.cn [Institute of Electromagnetics and Acoustics, and Department of Electronic Science, Xiamen, 361005 (China); Liu, Qing Huo, E-mail: qhliu@duke.edu [Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708 (United States)

2016-12-15

Numerical techniques in time domain are widespread in seismic and acoustic modeling. In some applications, however, frequency-domain techniques can be advantageous over the time-domain approach when narrow band results are desired, especially if multiple sources can be handled more conveniently in the frequency domain. Moreover, the medium attenuation effects can be more accurately and conveniently modeled in the frequency domain. In this paper, we present a spectral-element method (SEM) in frequency domain to simulate elastic and acoustic waves in anisotropic, heterogeneous, and lossy media. The SEM is based upon the finite-element framework and has exponential convergence because of the use of GLL basis functions. The anisotropic perfectly matched layer is employed to truncate the boundary for unbounded problems. Compared with the conventional finite-element method, the number of unknowns in the SEM is significantly reduced, and higher order accuracy is obtained due to its spectral accuracy. To account for the acoustic-solid interaction, the domain decomposition method (DDM) based upon the discontinuous Galerkin spectral-element method is proposed. Numerical experiments show the proposed method can be an efficient alternative for accurate calculation of elastic and acoustic waves in frequency domain.

A multi-domain spectral method for time-fractional differential equations

Science.gov (United States)

Chen, Feng; Xu, Qinwu; Hesthaven, Jan S.

2015-07-01

This paper proposes an approach for high-order time integration within a multi-domain setting for time-fractional differential equations. Since the kernel is singular or nearly singular, two main difficulties arise after the domain decomposition: how to properly account for the history/memory part and how to perform the integration accurately. To address these issues, we propose a novel hybrid approach for the numerical integration based on the combination of three-term-recurrence relations of Jacobi polynomials and high-order Gauss quadrature. The different approximations used in the hybrid approach are justified theoretically and through numerical examples. Based on this, we propose a new multi-domain spectral method for high-order accurate time integrations and study its stability properties by identifying the method as a generalized linear method. Numerical experiments confirm hp-convergence for both time-fractional differential equations and time-fractional partial differential equations.

High-Speed Microscale Optical Tracking Using Digital Frequency-Domain Multiplexing.

Science.gov (United States)

Maclachlan, Robert A; Riviere, Cameron N

2009-06-01

Position-sensitive detectors (PSDs), or lateral-effect photodiodes, are commonly used for high-speed, high-resolution optical position measurement. This paper describes the instrument design for multidimensional position and orientation measurement based on the simultaneous position measurement of multiple modulated sources using frequency-domain-multiplexed (FDM) PSDs. The important advantages of this optical configuration in comparison with laser/mirror combinations are that it has a large angular measurement range and allows the use of a probe that is small in comparison with the measurement volume. We review PSD characteristics and quantitative resolution limits, consider the lock-in amplifier measurement system as a communication link, discuss the application of FDM to PSDs, and make comparisons with time-domain techniques. We consider the phase-sensitive detector as a multirate DSP problem, explore parallels with Fourier spectral estimation and filter banks, discuss how to choose the modulation frequencies and sample rates that maximize channel isolation under design constraints, and describe efficient digital implementation. We also discuss hardware design considerations, sensor calibration, probe construction and calibration, and 3-D measurement by triangulation using two sensors. As an example, we characterize the resolution, speed, and accuracy of an instrument that measures the position and orientation of a 10 mm × 5 mm probe in 5 degrees of freedom (DOF) over a 30-mm cube with 4-μm peak-to-peak resolution at 1-kHz sampling.

On spectral resolutions of differential vector-operators

International Nuclear Information System (INIS)

Ashurov, R.R.; Sokolov, M.S.

2004-04-01

We show that spectral resolutions of differential vector-operators may be represented as a specific direct sum integral operator with a kernel written in terms of generalized vector-operator eigenfunctions. Then we prove that a generalized eigenfunction measurable with respect to the spectral parameter may be decomposed using a set of analytical defining systems of coordinate operators. (author)

Magnetic resonance imaging and spectroscopy at ultra high fields

International Nuclear Information System (INIS)

Neuberger, Thomas

2009-01-01

The goal of the work presented in this thesis was to explore the possibilities and limitations of MRI / MRS using an ultra high field of 17.6 tesla. A broad range of specific applications and MR methods, from MRI to MRSI and MRS were investigated. The main foci were on sodium magnetic resonance spectroscopic imaging of rodents, magnetic resonance spectroscopy of the mouse brain, and the detection of small amounts of iron labeled stem cells in the rat brain using MRI Sodium spectroscopic imaging was explored since it benefits tremendously from the high magnetic field. Due to the intrinsically low signal in vivo, originating from the low concentrations and short transverse relaxation times, only limited results have been achieved by other researchers until now. Results in the literature include studies conducted on large animals such as dogs to animals as small as rats. No studies performed on mice have been reported, despite the fact that the mouse is the most important laboratory animal due to the ready availability of transgenic strains. Hence, this study concentrated on sodium MRSI of small rodents, mostly mice (brain, heart, and kidney), and in the case of the brain on young rats. The second part of this work concentrated on proton magnetic resonance spectroscopy of the rodent brain. Due to the high magnetic field strength not only the increasing signal but also the extended spectral resolution was advantageous for such kind of studies. The difficulties/limitations of ultra high field MRS were also investigated. In the last part of the presented work detection limits of iron labeled stem cells in vivo using magnetic resonance imaging were explored. The studies provided very useful benchmarks for future researchers in terms of the number of labeled stem cells that are required for high-field MRI studies. Overall this work has shown many of the benefits and the areas that need special attention of ultra high fields in MR. Three topics in MRI, MRS and MRSI were

Magnetic resonance imaging and spectroscopy at ultra high fields

Energy Technology Data Exchange (ETDEWEB)

Neuberger, Thomas

2009-06-23

The goal of the work presented in this thesis was to explore the possibilities and limitations of MRI / MRS using an ultra high field of 17.6 tesla. A broad range of specific applications and MR methods, from MRI to MRSI and MRS were investigated. The main foci were on sodium magnetic resonance spectroscopic imaging of rodents, magnetic resonance spectroscopy of the mouse brain, and the detection of small amounts of iron labeled stem cells in the rat brain using MRI Sodium spectroscopic imaging was explored since it benefits tremendously from the high magnetic field. Due to the intrinsically low signal in vivo, originating from the low concentrations and short transverse relaxation times, only limited results have been achieved by other researchers until now. Results in the literature include studies conducted on large animals such as dogs to animals as small as rats. No studies performed on mice have been reported, despite the fact that the mouse is the most important laboratory animal due to the ready availability of transgenic strains. Hence, this study concentrated on sodium MRSI of small rodents, mostly mice (brain, heart, and kidney), and in the case of the brain on young rats. The second part of this work concentrated on proton magnetic resonance spectroscopy of the rodent brain. Due to the high magnetic field strength not only the increasing signal but also the extended spectral resolution was advantageous for such kind of studies. The difficulties/limitations of ultra high field MRS were also investigated. In the last part of the presented work detection limits of iron labeled stem cells in vivo using magnetic resonance imaging were explored. The studies provided very useful benchmarks for future researchers in terms of the number of labeled stem cells that are required for high-field MRI studies. Overall this work has shown many of the benefits and the areas that need special attention of ultra high fields in MR. Three topics in MRI, MRS and MRSI were

Improved mid infrared detector for high spectral or spatial resolution and synchrotron radiation use

Energy Technology Data Exchange (ETDEWEB)

Faye, Mbaye; Bordessoule, Michel; Kanouté, Brahim; Brubach, Jean-Blaise; Roy, Pascale [Synchrotron SOLEIL, L’Orme des Merisiers, F-91192 Gif-sur-Yvette (France); Manceron, Laurent [Synchrotron SOLEIL, L’Orme des Merisiers, F-91192 Gif-sur-Yvette (France); Laboratoire MONARIS, CNRS-Université Pierre et Marie Curie, UMR 8233, 4 Place Jussieu, F-75252 Paris Cedex (France)

2016-06-15

When using bright, small effective size sources, such as synchrotron radiation light beam, for broadband spectroscopy at spectral or spatial high resolution for mid-IR FTIR measurements, a marked detectivity improvement can be achieved by setting up a device matching the detector optical étendue to that of the source. Further improvement can be achieved by reducing the background unmodulated flux and other intrinsic noise sources using a lower temperature cryogen, such as liquid helium. By the combined use of cooled apertures, cold reimaging optics, filters and adapted detector polarization, and preamplification electronics, the sensitivity of a HgCdTe photoconductive IR detector can be improved by a significant factor with respect to standard commercial devices (more than one order of magnitude on average over 6–20 μm region) and the usable spectral range extended to longer wavelengths. The performances of such an optimized detector developed on the AILES Beamline at SOLEIL are presented here.

Enhanced spectral domain optical coherence tomography for pathological and functional studies

Science.gov (United States)

Yuan, Zhijia

Optical coherence tomography (OCT) is a novel technique that enables noninvasive or minimally invasive, cross-sectional imaging of biological tissue at sub-10mum spatial resolution and up to 2-3mm imaging depth. Numerous technological advances have emerged in recent years that have shown great potential to develop OCT into a powerful imaging and diagnostic tools. In particular, the implementation of Fourier-domain OCT (FDOCT) is a major step forward that leads to greatly improved imaging rate and image fidelity of OCT. This dissertation summarizes the work that focuses on enhancing the performances and functionalities of spectral radar based FDOCT (SDOCT) for pathological and functional applications. More specifically, chapters 1-4 emphasize on the development of SDOCT and its utility in pathological studies, including cancer diagnosis. The principle of SDOCT is first briefly outlined, followed by the design of our bench-top SDOCT systems with emphasis on spectral linear interpolation, calibration and system dispersion compensation. For ultrahigh-resolution SDOCT, time-lapse image registration and frame averaging is introduced to effectively reduce speckle noise and uncover subcellular details, showing great promise for enhancing the diagnosis of carcinoma in situ. To overcome the image depth limitation of OCT, a dual-modal imaging method combing SDOCT with high-frequency ultrasound is proposed and examined in animal cancer models to enhance the sensitivity and staging capabilities for bladder cancer diagnosis. Chapters 5-7 summarize the work on developing Doppler SDOCT for functional studies. Digital-frequency-ramping OCT (DFR-OCT) is developed in the study, which has demonstrated the ability to significantly improve the signal-to-noise ratio and thus sensitivity for retrieving subsurface blood flow imaging. New DFR algorithms and imaging processing methods are discussed to further enhance cortical CBF imaging. Applications of DFR-OCT for brain functional studies

High-speed spectral domain optical coherence tomography using non-uniform fast Fourier transform

Science.gov (United States)

Chan, Kenny K. H.; Tang, Shuo

2010-01-01

The useful imaging range in spectral domain optical coherence tomography (SD-OCT) is often limited by the depth dependent sensitivity fall-off. Processing SD-OCT data with the non-uniform fast Fourier transform (NFFT) can improve the sensitivity fall-off at maximum depth by greater than 5dB concurrently with a 30 fold decrease in processing time compared to the fast Fourier transform with cubic spline interpolation method. NFFT can also improve local signal to noise ratio (SNR) and reduce image artifacts introduced in post-processing. Combined with parallel processing, NFFT is shown to have the ability to process up to 90k A-lines per second. High-speed SD-OCT imaging is demonstrated at camera-limited 100 frames per second on an ex-vivo squid eye. PMID:21258551

Resolution enhancement of low-quality videos using a high-resolution frame

Science.gov (United States)

Pham, Tuan Q.; van Vliet, Lucas J.; Schutte, Klamer

2006-01-01

This paper proposes an example-based Super-Resolution (SR) algorithm of compressed videos in the Discrete Cosine Transform (DCT) domain. Input to the system is a Low-Resolution (LR) compressed video together with a High-Resolution (HR) still image of similar content. Using a training set of corresponding LR-HR pairs of image patches from the HR still image, high-frequency details are transferred from the HR source to the LR video. The DCT-domain algorithm is much faster than example-based SR in spatial domain 6 because of a reduction in search dimensionality, which is a direct result of the compact and uncorrelated DCT representation. Fast searching techniques like tree-structure vector quantization 16 and coherence search1 are also key to the improved efficiency. Preliminary results on MJPEG sequence show promising result of the DCT-domain SR synthesis approach.

Edge Detection from High Resolution Remote Sensing Images using Two-Dimensional log Gabor Filter in Frequency Domain

International Nuclear Information System (INIS)

Wang, K; Yu, T; Meng, Q Y; Wang, G K; Li, S P; Liu, S H

2014-01-01

Edges are vital features to describe the structural information of images, especially high spatial resolution remote sensing images. Edge features can be used to define the boundaries between different ground objects in high spatial resolution remote sensing images. Thus edge detection is important in the remote sensing image processing. Even though many different edge detection algorithms have been proposed, it is difficult to extract the edge features from high spatial resolution remote sensing image including complex ground objects. This paper introduces a novel method to detect edges from the high spatial resolution remote sensing image based on frequency domain. Firstly, the high spatial resolution remote sensing images are Fourier transformed to obtain the magnitude spectrum image (frequency image) by FFT. Then, the frequency spectrum is analyzed by using the radius and angle sampling. Finally, two-dimensional log Gabor filter with optimal parameters is designed according to the result of spectrum analysis. Finally, dot product between the result of Fourier transform and the log Gabor filter is inverse Fourier transformed to obtain the detections. The experimental result shows that the proposed algorithm can detect edge features from the high resolution remote sensing image commendably

High-Resolution Remote Sensing Image Building Extraction Based on Markov Model

Science.gov (United States)

Zhao, W.; Yan, L.; Chang, Y.; Gong, L.

2018-04-01

With the increase of resolution, remote sensing images have the characteristics of increased information load, increased noise, more complex feature geometry and texture information, which makes the extraction of building information more difficult. To solve this problem, this paper designs a high resolution remote sensing image building extraction method based on Markov model. This method introduces Contourlet domain map clustering and Markov model, captures and enhances the contour and texture information of high-resolution remote sensing image features in multiple directions, and further designs the spectral feature index that can characterize "pseudo-buildings" in the building area. Through the multi-scale segmentation and extraction of image features, the fine extraction from the building area to the building is realized. Experiments show that this method can restrain the noise of high-resolution remote sensing images, reduce the interference of non-target ground texture information, and remove the shadow, vegetation and other pseudo-building information, compared with the traditional pixel-level image information extraction, better performance in building extraction precision, accuracy and completeness.

Extending laser plasma accelerators into the mid-IR spectral domain with a next-generation ultra-fast CO2 laser

Science.gov (United States)

Pogorelsky, I. V.; Babzien, M.; Ben-Zvi, I.; Polyanskiy, M. N.; Skaritka, J.; Tresca, O.; Dover, N. P.; Najmudin, Z.; Lu, W.; Cook, N.; Ting, A.; Chen, Y.-H.

2016-03-01

Expanding the scope of relativistic plasma research to wavelengths longer than the λ/≈   0.8-1.1 μm range covered by conventional mode-locked solid-state lasers would offer attractive opportunities due to the quadratic scaling of the ponderomotive electron energy and critical plasma density with λ. Answering this quest, a next-generation mid-IR laser project is being advanced at the BNL ATF as a part of the user facility upgrade. We discuss the technical approach to this conceptually new 100 TW, 100 fs, λ  =   9-11 μm CO2 laser BESTIA (Brookhaven Experimental Supra-Terawatt Infrared at ATF) that encompasses several innovations applied for the first time to molecular gas lasers. BESTIA will enable new regimes of laser plasma accelerators. One example is shock-wave ion acceleration (SWA) from gas jets. We review ongoing efforts to achieve stable, monoenergetic proton acceleration by dynamically shaping the plasma density profile from a hydrogen gas target with laser-produced blast waves. At its full power, 100 TW BESTIA promises to achieve proton beams at an energy exceeding 200 MeV. In addition to ion acceleration in over-critical plasma, the ultra-intense mid-IR BESTIA will open up new opportunities in driving wakefields in tenuous plasmas, expanding the landscape of laser wakefield accelerator (LWFA) studies into the unexplored long-wavelength spectral domain. Simple wavelength scaling suggests that a 100 TW CO2 laser beam will be capable of efficiently generating plasma ‘bubbles’ a thousand times greater in volume compared with a near-IR solid state laser of an equivalent power. Combined with a femtosecond electron linac available at the ATF, this wavelength scaling will facilitate the study of external seeding and staging of LWFAs.

Spectral element method for wave propagation on irregular domains

Indian Academy of Sciences (India)

A spectral element approximation of acoustic propagation problems combined with a new mapping method on irregular domains is proposed. Following this method, the Gauss–Lobatto–Chebyshev nodes in the standard space are applied to the spectral element method (SEM). The nodes in the physical space are ...

High spatial resolution three-dimensional mapping of vegetation spectral dynamics using computer vision and hobbyist unmanned aerial vehicles

Science.gov (United States)

Dandois, J. P.; Ellis, E. C.

2013-12-01

High spatial resolution three-dimensional (3D) measurements of vegetation by remote sensing are advancing ecological research and environmental management. However, substantial economic and logistical costs limit this application, especially for observing phenological dynamics in ecosystem structure and spectral traits. Here we demonstrate a new aerial remote sensing system enabling routine and inexpensive aerial 3D measurements of canopy structure and spectral attributes, with properties similar to those of LIDAR, but with RGB (red-green-blue) spectral attributes for each point, enabling high frequency observations within a single growing season. This 'Ecosynth' methodology applies photogrammetric ''Structure from Motion'' computer vision algorithms to large sets of highly overlapping low altitude (USA. Ecosynth canopy height maps (CHMs) were strong predictors of field-measured tree heights (R2 0.63 to 0.84) and were highly correlated with a LIDAR CHM (R 0.87) acquired 4 days earlier, though Ecosynth-based estimates of aboveground biomass densities included significant errors (31 - 36% of field-based estimates). Repeated scanning of a 0.25 ha forested area at six different times across a 16 month period revealed ecologically significant dynamics in canopy color at different heights and a structural shift upward in canopy density, as demonstrated by changes in vertical height profiles of point density and relative RGB brightness. Changes in canopy relative greenness were highly correlated (R2 = 0.88) with MODIS NDVI time series for the same area and vertical differences in canopy color revealed the early green up of the dominant canopy species, Liriodendron tulipifera, strong evidence that Ecosynth time series measurements capture vegetation structural and spectral dynamics at the spatial scale of individual trees. Observing canopy phenology in 3D at high temporal resolutions represents a breakthrough in forest ecology. Inexpensive user-deployed technologies for

Full-range k-domain linearization in spectral-domain optical coherence tomography.

Science.gov (United States)

Jeon, Mansik; Kim, Jeehyun; Jung, Unsang; Lee, Changho; Jung, Woonggyu; Boppart, Stephen A

2011-03-10

A full-bandwidth k-domain linearization method for spectral-domain optical coherence tomography (SD-OCT) is demonstrated. The method uses information of the wavenumber-pixel-position provided by a translating-slit-based wavelength filter. For calibration purposes, the filter is placed either after a broadband source or at the end of the sample path, and the filtered spectrum with a narrowed line width (∼0.5 nm) is incident on a line-scan camera in the detection path. The wavelength-swept spectra are co-registered with the pixel positions according to their central wavelengths, which can be automatically measured with an optical spectrum analyzer. For imaging, the method does not require a filter or a software recalibration algorithm; it simply resamples the OCT signal from the detector array without employing rescaling or interpolation methods. The accuracy of k-linearization is maximized by increasing the k-linearization order, which is known to be a crucial parameter for maintaining a narrow point-spread function (PSF) width at increasing depths. The broadening effect is studied by changing the k-linearization order by undersampling to search for the optimal value. The system provides more position information, surpassing the optimum without compromising the imaging speed. The proposed full-range k-domain linearization method can be applied to SD-OCT systems to simplify their hardware/software, increase their speed, and improve the axial image resolution. The experimentally measured width of PSF in air has an FWHM of 8 μm at the edge of the axial measurement range. At an imaging depth of 2.5 mm, the sensitivity of the full-range calibration case drops less than 10 dB compared with the uncompensated case.

Design of an ultra-thin dual band infrared system

Science.gov (United States)

Du, Ke; Cheng, Xuemin; Lv, Qichao; Hu, YiFei

2014-11-01

The ultra-thin imaging system using reflective multiple-fold structure has smaller volume and less weight while maintaining high resolution compared with conventional optical systems. The multi-folded approach can significantly extend focal distance within wide spectral range without incurring chromatic aberrations. In this paper, we present a dual infrared imaging system of four-folded reflection with two air-spaced concentric reflective surfaces. The dual brand IR system has 107mm effective focal length, 0.7NA, +/-4° FOV, and 50mm effective aperture with 80mm outer diameter into a 25mm total thickness, which spectral response is 3~12μm.

Spectral element method for wave propagation on irregular domains

Indian Academy of Sciences (India)

Yan Hui Geng

2018-03-14

Mar 14, 2018 ... Abstract. A spectral element approximation of acoustic propagation problems combined with a new mapping method on irregular domains is proposed. Following this method, the Gauss–Lobatto–Chebyshev nodes in the standard space are applied to the spectral element method (SEM). The nodes in the ...

X-RAY HIGH-RESOLUTION SPECTROSCOPY REVEALS FEEDBACK IN A SEYFERT GALAXY FROM AN ULTRA-FAST WIND WITH COMPLEX IONIZATION AND VELOCITY STRUCTURE

International Nuclear Information System (INIS)

Longinotti, A. L.; Krongold, Y.; Guainazzi, M.; Santos-Lleo, M.; Rodriguez-Pascual, P.; Giroletti, M.; Panessa, F.; Costantini, E.

2015-01-01

Winds outflowing from active galactic nuclei (AGNs) may carry significant amounts of mass and energy out to their host galaxies. In this paper we report the detection of a sub-relativistic outflow observed in the narrow line Seyfert 1 galaxy IRAS 17020+4544 as a series of absorption lines corresponding to at least five absorption components with an unprecedented wide range of associated column densities and ionization levels and velocities in the range of 23,000–33,000 km s −1 , detected at X-ray high spectral resolution (E/ΔE ∼ 1000) with the ESA's observatory XMM-Newton. The charge states of the material constituting the wind clearly indicate a range of low to moderate ionization states in the outflowing gas and column densities that are significantly lower than observed in highly ionized ultra-fast outflows. We estimate that at least one of the outflow components may carry sufficient energy to substantially suppress star formation and heat the gas in the host galaxy. IRAS 17020+4544 therefore provides an interesting example of feedback by a moderately luminous AGN that is hosted in a spiral galaxy, a case barely envisaged in most evolution models, which often predict that feedback processes take place in massive elliptical galaxies hosting luminous quasars in a post-merger phase

X-RAY HIGH-RESOLUTION SPECTROSCOPY REVEALS FEEDBACK IN A SEYFERT GALAXY FROM AN ULTRA-FAST WIND WITH COMPLEX IONIZATION AND VELOCITY STRUCTURE

Energy Technology Data Exchange (ETDEWEB)

Longinotti, A. L. [Catedrática CONACYT—Instituto Nacional de Astrofísica, Óptica y Electrónica, Luis E. Erro 1, Tonantzintla, Puebla, C.P. 72840, México (Mexico); Krongold, Y. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Apartado Postal 70264, 04510 Mexico D.F. (Mexico); Guainazzi, M.; Santos-Lleo, M.; Rodriguez-Pascual, P. [ESAC, P.O. Box, 78 E-28691 Villanueva de la Cañada, Madrid (Spain); Giroletti, M. [INAF Osservatorio di Radioastronomia, via Gobetti 101, I-40129 Bologna (Italy); Panessa, F. [INAF—Istituto di Astrofisica e Planetologia Spaziali di Roma (IAPS), Via del Fosso del Cavaliere 100, I-00133 Roma (Italy); Costantini, E. [SRON Netherlands Institute for Space Research, Sorbonnelaan 2, 3584 CA Utrecht (Netherlands)

2015-11-10

Winds outflowing from active galactic nuclei (AGNs) may carry significant amounts of mass and energy out to their host galaxies. In this paper we report the detection of a sub-relativistic outflow observed in the narrow line Seyfert 1 galaxy IRAS 17020+4544 as a series of absorption lines corresponding to at least five absorption components with an unprecedented wide range of associated column densities and ionization levels and velocities in the range of 23,000–33,000 km s{sup −1}, detected at X-ray high spectral resolution (E/ΔE ∼ 1000) with the ESA's observatory XMM-Newton. The charge states of the material constituting the wind clearly indicate a range of low to moderate ionization states in the outflowing gas and column densities that are significantly lower than observed in highly ionized ultra-fast outflows. We estimate that at least one of the outflow components may carry sufficient energy to substantially suppress star formation and heat the gas in the host galaxy. IRAS 17020+4544 therefore provides an interesting example of feedback by a moderately luminous AGN that is hosted in a spiral galaxy, a case barely envisaged in most evolution models, which often predict that feedback processes take place in massive elliptical galaxies hosting luminous quasars in a post-merger phase.

Interferometric filters for spectral discrimination in high-spectral-resolution lidar: performance comparisons between Fabry-Perot interferometer and field-widened Michelson interferometer.

Science.gov (United States)

Cheng, Zhongtao; Liu, Dong; Yang, Yongying; Yang, Liming; Huang, Hanlu

2013-11-10

Thanks to wavelength flexibility, interferometric filters such as Fabry-Perot interferometers (FPIs) and field-widened Michelson interferometers (FWMIs) have shown great convenience for spectrally separating the molecule and aerosol scattering components in the high-spectral-resolution lidar (HSRL) return signal. In this paper, performance comparisons between the FPI and FWMI as a spectroscopic discrimination filter in HSRL are performed. We first present a theoretical method for spectral transmission analysis and quantitative evaluation on the spectral discrimination. Then the process in determining the parameters of the FPI and FWMI for the performance comparisons is described. The influences from the incident field of view (FOV), the cumulative wavefront error induced by practical imperfections, and the frequency locking error on the spectral discrimination performance of the two filters are discussed in detail. Quantitative analyses demonstrate that FPI can produce higher transmittance while the remarkable spectral discrimination is one of the most appealing advantages of FWMI. As a result of the field-widened design, the FWMI still performs well even under the illumination with large FOV while the FPI is only qualified for a small incident angle. The cumulative wavefront error attaches a great effect on the spectral discrimination performance of the interferometric filters. We suggest if a cumulative wavefront error is less than 0.05 waves RMS, it is beneficial to employ the FWMI; otherwise, FPI may be more proper. Although the FWMI shows much more sensitivity to the frequency locking error, it can outperform the FPI given a locking error less than 0.1 GHz is achieved. In summary, the FWMI is very competent in HSRL applications if these practical engineering and control problems can be solved, theoretically. Some other estimations neglected in this paper can also be carried out through the analytical method illustrated herein.

High resolution γ-ray spectroscopy: The first 85 years

International Nuclear Information System (INIS)

Deslattes, R.D.

2000-01-01

This opening review attempts to follow the main trends in crystal diffraction spectrometry of nuclear γ rays from its 1914 beginning in Rutherford's laboratory to the ultra-high resolution instrumentation realized in the current generation of spectrometers at the Institute Laue Langeven (ILL). The authors perspective is that of an instrumentalist hoping to convey a sense of intellectual debt to a number of predecessors, each of whom realized a certain elegance in making the tools that have enabled much good science, including that to which the remainder of this workshop is dedicated. This overview follows some of the main ideas along a trajectory toward higher resolution at higher energies, thereby enabling not only the disentangling of dense spectra, but also allowing detailed study of aspects of spectral profiles sensitive to excited state lifetimes and interatomic potentials. The parallel evolution toward increasing efficiency while preserving needed resolution is also an interesting story of artful compromise that should not be neglected. Finally, it is the robustness of the measurement chain connecting γ-ray wavelengths with optical wave-lengths associated with the Rydberg constant that only recently has allowed γ-ray data to contribute to determine of particle masses and fundamental constants, as will be described in more detail in other papers from this workshop

Digital spectral analysis parametric, non-parametric and advanced methods

CERN Document Server

Castanié, Francis

2013-01-01

Digital Spectral Analysis provides a single source that offers complete coverage of the spectral analysis domain. This self-contained work includes details on advanced topics that are usually presented in scattered sources throughout the literature.The theoretical principles necessary for the understanding of spectral analysis are discussed in the first four chapters: fundamentals, digital signal processing, estimation in spectral analysis, and time-series models.An entire chapter is devoted to the non-parametric methods most widely used in industry.High resolution methods a

WIDEFIELD SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING OF PERIPHERAL ROUND RETINAL HOLES WITH OR WITHOUT RETINAL DETACHMENT.

Science.gov (United States)

Casswell, Edward J; Abou Ltaif, Sleiman; Carr, Thomas; Keane, Pearse A; Charteris, David G; Wickham, Louisa

2018-03-02

To describe the widefield spectral-domain optical coherence tomography features of peripheral round retinal holes, with or without associated retinal detachment (RD). Retrospective, observational study of 28 eyes with peripheral round retinal holes, with and without RD. Patients underwent imaging with a widefield 50-degree spectral-domain optical coherence tomography (Heidelberg Engineering, Germany) and Optos ultra-widefield imaging systems (Optos, United Kingdom). Vitreous attachment at the site of the retinal hole was detected in 27/28 (96.4%) cases. Cases were split into three groups: RHs with RD (n = 12); RHs with subretinal fluid (n = 5), and flat RHs (n = 11), with minimal or no subretinal fluid. 91.6% retinal holes associated with subretinal fluid or RD had vitreous attachment at the site of the hole. Eighty percent had vitreous attachment at both edges of the retinal hole, in a U-shape configuration, which appeared to exert traction. By contrast, flat retinal holes had visible vitreous attachment only at one edge of the retinal hole in 45.4%. Vitreous attachment was commonly seen at the site of round retinal holes. Vitreous attachment at both edges of the retinal hole in a U-shape configuration was more commonly seen at holes associated with subretinal fluid or RD.

Design and performance of a soft-x-ray interferometer for ultra-high-resolution fourier transform spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Moler, E.J.; Hussain, Z.; Duarte, R.M.; Howells, M.R. [Lawrence Berkeley National Lab., CA (United States)

1997-04-01

A Fourier Transform Soft X-ray spectrometer (FT-SX) has been designed and is under construction for the Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory as a branch of beamline 9.3.2. The spectrometer is a novel soft x-ray interferometer designed for ultra-high resolution (theoretical resolving power E/{delta}E{approximately}10{sup 6}) spectroscopy in the photon energy region of 60-120 eV. This instrument is expected to provide experimental results which sensitively test models of correlated electron processes in atomic and molecular physics. The design criteria and consequent technical challenges posed by the short wavelengths of x-rays and desired resolving power are discussed. The fundamental and practical aspects of soft x-ray interferometry are also explored.

Polyphase tectono-magmatic and fluid history related to mantle exhumation in an ultra-distal rift domain: example of the fossil Platta domain, SE Switzerland

Science.gov (United States)

Epin, Marie-Eva; Manatschal, Gianreto; Amann, Méderic; Lescanne, Marc

2017-04-01

Despite the fact that many studies have investigated mantle exhumation at magma-poor rifted margins, there are still numerous questions concerning the 3D architecture, magmatic, fluid and thermal evolution of these ultra-distal domains that remain unexplained. Indeed, it has been observed in seismic data from ultra-distal magma-poor rifted margins that top basement is heavily structured and complex, however, the processes controlling the morpho-tectonic and magmatic evolution of these domains remain unknown. The aim of this study is to describe the 3D top basement morphology of an exhumed mantle domain, exposed over 200 km2 in the fossil Platta domain in SE Switzerland, and to define the timing and processes controlling its evolution. The examined Platta nappe corresponds to a remnant of the former ultra-distal Adriatic margin of the Alpine Tethys. The rift-structures are relatively well preserved due to the weak Alpine tectonic and metamorphic overprint during the emplacement in the Alpine nappe stack. Detailed mapping of parts of the Platta nappe enabled us to document the top basement architecture of an exhumed mantle domain and to investigate its link to later, rift/oceanic structures, magmatic additions and fluids. Our observations show a polyphase and/or complex: 1) deformation history associated with mantle exhumation along low-angle exhumation faults overprinted by later high-angle normal faults, 2) top basement morphology capped by magmato-sedimentary rocks, 3) tectono-magmatic evolution that includes gabbros, emplaced at deeper levels and subsequently exhumed and overlain by younger extrusive magmatic additions, and 4) fluid history including serpentinization, calcification, hydrothermal vent, rodingitization and spilitization affecting exhumed mantle and associated magmatic rocks. The overall observations provide important information on the temporal and spatial evolution of the tectonic, magmatic and fluid systems controlling the formation of ultra

Advances in spectral inversion of time-domain induced polarization

DEFF Research Database (Denmark)

Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

The extraction of spectral information in the inversion process of time-domain (TD) induced polarization (IP) data is changing the use of the TDIP method. Data interpretation is evolving from a qualitative description of the subsurface, able only to discriminate the presence of contrasts in charg......The extraction of spectral information in the inversion process of time-domain (TD) induced polarization (IP) data is changing the use of the TDIP method. Data interpretation is evolving from a qualitative description of the subsurface, able only to discriminate the presence of contrasts...... in chargeability parameters, towards a quantitative analysis of the investigated media, which allows for detailed soil- and rock-type characterization. In this work a review of the recent advances in spectral inversion of TDIP data is presented, in terms of: supported IP parameterizations; modelling of transmitter...

PCA determination of the radiometric noise of high spectral resolution infrared observations from spectral residuals: Application to IASI

Science.gov (United States)

Serio, C.; Masiello, G.; Camy-Peyret, C.; Jacquette, E.; Vandermarcq, O.; Bermudo, F.; Coppens, D.; Tobin, D.

2018-02-01

The problem of characterizing and estimating the instrumental or radiometric noise of satellite high spectral resolution infrared spectrometers directly from Earth observations is addressed in this paper. An approach has been developed, which relies on the Principal Component Analysis (PCA) with a suitable criterion to select the optimal number of PC scores. Different selection criteria have been set up and analysed, which is based on the estimation theory of Least Squares and/or Maximum Likelihood Principle. The approach is independent of any forward model and/or radiative transfer calculations. The PCA is used to define an orthogonal basis, which, in turn, is used to derive an optimal linear reconstruction of the observations. The residual vector that is the observation vector minus the calculated or reconstructed one is then used to estimate the instrumental noise. It will be shown that the use of the spectral residuals to assess the radiometric instrumental noise leads to efficient estimators, which are largely independent of possible departures of the true noise from that assumed a priori to model the observational covariance matrix. Application to the Infrared Atmospheric Sounder Interferometer (IASI) has been considered. A series of case studies has been set up, which make use of IASI observations. As a major result, the analysis confirms the high stability and radiometric performance of IASI. The approach also proved to be efficient in characterizing noise features due to mechanical micro-vibrations of the beam splitter of the IASI instrument.

Simulating return signals of a spaceborne high-spectral resolution lidar channel at 532 nm

Science.gov (United States)

Xiao, Yu; Binglong, Chen; Min, Min; Xingying, Zhang; Lilin, Yao; Yiming, Zhao; Lidong, Wang; Fu, Wang; Xiaobo, Deng

2018-06-01

High spectral resolution lidar (HSRL) system employs a narrow spectral filter to separate the particulate (cloud/aerosol) and molecular scattering components in lidar return signals, which improves the quality of the retrieved cloud/aerosol optical properties. To better develop a future spaceborne HSRL system, a novel simulation technique was developed to simulate spaceborne HSRL return signals at 532 nm using the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) cloud/aerosol extinction coefficients product and numerical weather prediction data. For validating simulated data, a mathematical particulate extinction coefficient retrieval method for spaceborne HSRL return signals is described here. We compare particulate extinction coefficient profiles from the CALIPSO operational product with simulated spaceborne HSRL data. Further uncertainty analysis shows that relative uncertainties are acceptable for retrieving the optical properties of cloud and aerosol. The final results demonstrate that they agree well with each other. It indicates that the return signals of the spaceborne HSRL molecular channel at 532 nm will be suitable for developing operational algorithms supporting a future spaceborne HSRL system.

Ultra-high Performance Liquid Chromatography in Steroid Analysis

OpenAIRE

Salonen, Fanny

2017-01-01

The latest version of liquid chromatography is ultra-high performance (or pressure) chromatography (UHPLC). In the technique, short and narrow-bore columns with particle sizes below 3 µm are used. The extremely high pressure used results in very short analysis times, excellent separation, and good resolution. This makes UHPLC a good choice for steroidal analysis. Steroids are a highly interesting area of study; they can be recognized as biomarkers for several diseases and are a relevant topic...

Set-up of a high-resolution 300 mK atomic force microscope in an ultra-high vacuum compatible "3He/10 T cryostat

International Nuclear Information System (INIS)

Allwörden, H. von; Ruschmeier, K.; Köhler, A.; Eelbo, T.; Schwarz, A.; Wiesendanger, R.

2016-01-01

The design of an atomic force microscope with an all-fiber interferometric detection scheme capable of atomic resolution at about 500 mK is presented. The microscope body is connected to a small pumped "3He reservoir with a base temperature of about 300 mK. The bakeable insert with the cooling stage can be moved from its measurement position inside the bore of a superconducting 10 T magnet into an ultra-high vacuum chamber, where the tip and sample can be exchanged in situ. Moreover, single atoms or molecules can be evaporated onto a cold substrate located inside the microscope. Two side chambers are equipped with standard surface preparation and surface analysis tools. The performance of the microscope at low temperatures is demonstrated by resolving single Co atoms on Mn/W(110) and by showing atomic resolution on NaCl(001).

Spectral Resolution-linked Bias in Transit Spectroscopy of Extrasolar Planets

Science.gov (United States)

Deming, Drake; Sheppard, Kyle

2017-05-01

We re-visit the principles of transmission spectroscopy for transiting extrasolar planets, focusing on the overlap between the planetary spectrum and the illuminating stellar spectrum. Virtually all current models of exoplanetary transmission spectra utilize an approximation that is inaccurate when the spectrum of the illuminating star has a complex line structure, such as molecular bands in M-dwarf spectra. In those cases, it is desirable to model the observations using a coupled stellar-planetary radiative transfer model calculated at high spectral resolving power, followed by convolution to the observed resolution. Not consistently accounting for overlap of stellar M-dwarf and planetary lines at high spectral resolution can bias the modeled amplitude of the exoplanetary transmission spectrum, producing modeled absorption that is too strong. We illustrate this bias using the exoplanet TRAPPIST-1b, as observed using Hubble Space Telescope/WFC3. The bias in this case is about 250 ppm, 12% of the modeled transit absorption. Transit spectroscopy using JWST will have access to longer wavelengths where the water bands are intrinsically stronger, and the observed signal-to-noise ratios will be higher than currently possible. We therefore expect that this resolution-linked bias will be especially important for future JWST observations of TESS-discovered super-Earths and mini-Neptunes transiting M-dwarfs.

Spectral Resolution-linked Bias in Transit Spectroscopy of Extrasolar Planets

Energy Technology Data Exchange (ETDEWEB)

Deming, Drake; Sheppard, Kyle [Department of Astronomy, University of Maryland at College Park, College Park, MD 20742 (United States)

2017-05-20

We re-visit the principles of transmission spectroscopy for transiting extrasolar planets, focusing on the overlap between the planetary spectrum and the illuminating stellar spectrum. Virtually all current models of exoplanetary transmission spectra utilize an approximation that is inaccurate when the spectrum of the illuminating star has a complex line structure, such as molecular bands in M-dwarf spectra. In those cases, it is desirable to model the observations using a coupled stellar–planetary radiative transfer model calculated at high spectral resolving power, followed by convolution to the observed resolution. Not consistently accounting for overlap of stellar M-dwarf and planetary lines at high spectral resolution can bias the modeled amplitude of the exoplanetary transmission spectrum, producing modeled absorption that is too strong. We illustrate this bias using the exoplanet TRAPPIST-1b, as observed using Hubble Space Telescope /WFC3. The bias in this case is about 250 ppm, 12% of the modeled transit absorption. Transit spectroscopy using JWST will have access to longer wavelengths where the water bands are intrinsically stronger, and the observed signal-to-noise ratios will be higher than currently possible. We therefore expect that this resolution-linked bias will be especially important for future JWST observations of TESS-discovered super-Earths and mini-Neptunes transiting M-dwarfs.

Spectral Resolution-linked Bias in Transit Spectroscopy of Extrasolar Planets

International Nuclear Information System (INIS)

Deming, Drake; Sheppard, Kyle

2017-01-01

We re-visit the principles of transmission spectroscopy for transiting extrasolar planets, focusing on the overlap between the planetary spectrum and the illuminating stellar spectrum. Virtually all current models of exoplanetary transmission spectra utilize an approximation that is inaccurate when the spectrum of the illuminating star has a complex line structure, such as molecular bands in M-dwarf spectra. In those cases, it is desirable to model the observations using a coupled stellar–planetary radiative transfer model calculated at high spectral resolving power, followed by convolution to the observed resolution. Not consistently accounting for overlap of stellar M-dwarf and planetary lines at high spectral resolution can bias the modeled amplitude of the exoplanetary transmission spectrum, producing modeled absorption that is too strong. We illustrate this bias using the exoplanet TRAPPIST-1b, as observed using Hubble Space Telescope /WFC3. The bias in this case is about 250 ppm, 12% of the modeled transit absorption. Transit spectroscopy using JWST will have access to longer wavelengths where the water bands are intrinsically stronger, and the observed signal-to-noise ratios will be higher than currently possible. We therefore expect that this resolution-linked bias will be especially important for future JWST observations of TESS-discovered super-Earths and mini-Neptunes transiting M-dwarfs.

Sensitivity study of heavy precipitation in Limited Area Model climate simulations: influence of the size of the domain and the use of the spectral nudging technique

Science.gov (United States)

Colin, Jeanne; Déqué, Michel; Radu, Raluca; Somot, Samuel

2010-10-01

We assess the impact of two sources of uncertainties in a limited area model (LAM) on the representation of intense precipitation: the size of the domain of integration and the use of the spectral nudging technique (driving of the large-scale within the domain of integration). We work in a perfect-model approach where the LAM is driven by a general circulation model (GCM) run at the same resolution and sharing the same physics and dynamics as the LAM. A set of three 50 km resolution simulations run over Western Europe with the LAM ALADIN-Climate and the GCM ARPEGE-Climate are performed to address this issue. Results are consistent with previous studies regarding the seasonal-mean fields. Furthermore, they show that neither the use of the spectral nudging nor the choice of a small domain are detrimental to the modelling of heavy precipitation in the present experiment.

Spatial Analysis of High-Resolution Radar Rainfall and Citizen-Reported Flash Flood Data in Ultra-Urban New York City

Directory of Open Access Journals (Sweden)

Brianne Smith

2017-09-01

Full Text Available New York City (NYC is an ultra-urban region, with over 50% impervious cover and buried stream channels. Traditional flood studies rely on the presence of stream gages to detect flood stage and discharge, but these methods cannot be used in ultra-urban areas. Here we create a high-resolution radar rainfall dataset for NYC and utilize citizen and expert reports of flooding throughout the city to study flash flooding in NYC. Results indicate that interactions between the urban area and land–sea boundary have an important impact on the spatial variability of both heavy rainfall and flooding, sometimes in contrast to results obtained for other cities. Top days of daily and hourly rainfall exhibit a rainfall maximum over the city center and an extended region of higher rainfall downwind of the city. The mechanism for flooding appears to vary across the city, with high groundwater tables influencing more coastal areas and high rain rates or large rain volumes influencing more inland areas. There is also a strong relationship between sewer type and flood frequency, with fewer floods observed in combined sewer areas. Flooding is driven by maximum one-hour to one-day rainfall, which is often substantially less rain than observed for the city-wide daily maximum.

High spectral resolution observations of the H2 2.12 micron line in Herbig-Haro objects

International Nuclear Information System (INIS)

Zinnecker, H.; Mundt, R.; Geballe, T.R.; Zealey, W.J.

1989-01-01

High-spectral-resolution Fabry-Perot observations of the H 2 2.12-micron line emissions of several Herbig-Haro (HH) objects are discussed. It is shown that H 2 emission by the shock heating of external molecular gas in the wings of the bow shock associated with the working surface of a high-velocity jet may occur for HH objects associated with the jet's end. The shock heating of external molecular gas entrained in the flow by internal shocks occurring in the jet itself and/or in its boundary layer may be the H 2 emission mechanism for HH objects observed along the flow axis. 59 refs

High Time-Resolution 640-Gb/s Clock Recovery Using Time-Domain Optical Fourier Transformation and Narrowband Optical Filter

DEFF Research Database (Denmark)

Guan, P.; Mulvad, Hans Christian Hansen; Kasai, K.

2010-01-01

We present a novel scheme for subharmonic clock recovery from an optical time-division-multiplexing signal using time-domain optical Fourier transformation and a narrowband optical filter. High-resolution 640-Gb/s clock recovery is successfully demonstrated with no pattern dependence. The clock...

Resolution enhancement of low quality videos using a high-resolution frame

NARCIS (Netherlands)

Pham, T.Q.; Van Vliet, L.J.; Schutte, K.

2006-01-01

This paper proposes an example-based Super-Resolution (SR) algorithm of compressed videos in the Discrete Cosine Transform (DCT) domain. Input to the system is a Low-Resolution (LR) compressed video together with a High-Resolution (HR) still image of similar content. Using a training set of

Advanced MR methods at ultra-high field (7 Tesla) for clinical musculoskeletal applications

Energy Technology Data Exchange (ETDEWEB)

Trattnig, Siegfried [Medical University of Vienna/Vienna General Hospital, MR Centre - High Field MR, Department of Radiology, Vienna (Austria); Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Vienna (Austria); Zbyn, Stefan; Schmitt, Benjamin; Friedrich, Klaus; Bogner, Wolfgang [Medical University of Vienna/Vienna General Hospital, MR Centre - High Field MR, Department of Radiology, Vienna (Austria); Juras, Vladimir; Szomolanyi, Pavol [Medical University of Vienna/Vienna General Hospital, MR Centre - High Field MR, Department of Radiology, Vienna (Austria); Slovak Academy of Sciences, Department of Imaging Methods, Institute of Measurement Science, Bratislava (Slovakia)

2012-11-15

This article provides an overview of the initial clinical results of musculoskeletal studies performed at 7 Tesla, with special focus on sodium imaging, new techniques such as chemical exchange saturation transfer (CEST) and T2* imaging, and multinuclear MR spectroscopy. Sodium imaging was clinically used at 7 T in the evaluation of patients after cartilage repair procedures because it enables the GAG content to be monitored over time. Sodium imaging and T2* mapping allow insights into the ultra-structural composition of the Achilles tendon and help detect early disease. Chemical exchange saturation transfer was, for the first time, successfully applied in the clinical set-up at 7 T in patients after cartilage repair surgery. The potential of phosphorus MR spectroscopy in muscle was demonstrated in a comparison study between 3 and 7 T, with higher spectral resolution and significantly shorter data acquisition times at 7 T. These initial clinical studies demonstrate the potential of ultra-high field MR at 7 T, with the advantage of significantly improved sensitivity for other nuclei, such as {sup 23}Na (sodium) and {sup 31}P (phosphorus). The application of non-proton imaging and spectroscopy provides new insights into normal and abnormal physiology of musculoskeletal tissues, particularly cartilage, tendons, and muscles. (orig.)

High-resolution measurement, line identification, and spectral modeling of the Kβ spectrum of heliumlike argon emitted by a laser-produced plasma using a gas-puff target

International Nuclear Information System (INIS)

Skobelev, I.Y.; Faenov, A.Y.; Dyakin, V.M.; Fiedorowicz, H.; Bartnik, A.; Szczurek, M.; Beiersdorfer, P.; Nilsen, J.; Osterheld, A.L.

1997-01-01

We present an analysis of the spectrum of satellite transitions to the He-β line in ArXVII. High-resolution measurements of the spectra from laser-heated Ar-gas-puff targets are made with spectral resolution of 10000 and spatial resolution of better than 50 μm. These are compared with tokamak measurements. Several different lines are identified in the spectra and the spectral analysis is used to determine the plasma parameters in the gas-puff laser-produced plasma. The data complement those from tokamak measurements to provide more complete information on the satellite spectra. copyright 1997 The American Physical Society

SOFIA/EXES High Spectral Resolution Observations of the Orion Hot Core

Science.gov (United States)

Rangwala, Naseem; Colgan, Sean; Le Gal, Romane; Acharya, Kinsuk; Huang, Xinchuan; Herbst, Eric; Lee, Timothy J.; Richter, Matthew J.; Boogert, Adwin

2018-01-01

The Orion hot core has one of the richest molecular chemistries observed in the ISM. In the MIR, the Orion hot core composition is best probed by the closest, compact, bright background continuum source in this region, IRc2. We present high-spectral resolution observations from 12.96 - 13.33 μm towards Orion IRc2 using the mid-infrared spectrograph, EXES, on SOFIA, to probe the physical and chemical conditions of the Orion hot core. All ten of the rovibrational C2H2 transitions expected in our spectral coverage, are detected with high S/N, yielding continuous coverage of the R-branch lines from J=9-8 to J=18-17, including both ortho and para species. Eight of these rovibrational transitions are newly reported detections. These data show distinct ortho and para ladders towards the Orion hot core for the first time, with an ortho to para ratio (OPR) of only 0.6 - much lower than the high temperature equilibrium value of 3. A non-equilibrium OPR is a further indication of the Orion hot core being heated externally by shocks likely resulting from a well-known explosive event which occurred 500 yrs ago. The OPR conversion timescales are much longer than the 500 yr shock timescale and thus a low OPR might be a remnant from an earlier colder pre-stellar phase before the density enhancement (now the hot core) was impacted by shocks.We will also present preliminary results from an on-going SOFIA Cycle-5 impact program to use EXES to conduct an unbiased, high-S/N, continuous, molecular line survey of the Orion hot core from 12.5 - 28.3 microns. This survey is expected to be 50 times better than ISO in detecting isolated, narrow lines to (a) resolve the ro-vibrational structure of the gas phase molecules and their kinematics, (b) detect new gas phase molecules missed by ISO, and (c) provide useful constraints on the hot core chemistry and the source of Orion hot core excitation. This survey will greatly enhance the inventory of resolved line features in the MIR for hot cores

Differences between time domain and Fourier domain optical coherence tomography in imaging tissues.

Science.gov (United States)

Gao, W; Wu, X

2017-11-01

It has been numerously demonstrated that both time domain and Fourier domain optical coherence tomography (OCT) can generate high-resolution depth-resolved images of living tissues and cells. In this work, we compare the common points and differences between two methods when the continuous and random properties of live tissue are taken into account. It is found that when relationships that exist between the scattered light and tissue structures are taken into account, spectral interference measurements in Fourier domain OCT (FDOCT) is more advantageous than interference fringe envelope measurements in time domain OCT (TDOCT) in the cases where continuous property of tissue is taken into account. It is also demonstrated that when random property of tissue is taken into account FDOCT measures the Fourier transform of the spatial correlation function of the refractive index and speckle phenomena will limit the effective limiting imaging resolution in both TDOCT and FDOCT. Finally, the effective limiting resolution of both TDOCT and FDOCT are given which can be used to estimate the effective limiting resolution in various practical applications. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry.

Science.gov (United States)

Tomková, Jana; Ondra, Peter; Válka, Ivo

2015-06-01

This paper presents a method for the simultaneous determination of α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction (SPE) and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. The method can be used for a diagnostics of mushroom poisonings. Different SPE cartridges were tested for sample preparation, namely hydrophilic modified reversed-phase (Oasis HLB) and polymeric weak cation phase (Strata X-CW). The latter gave better results and therefore it was chosen for the subsequent method optimization and partial validation. In the course of validation, limits of detection, linearity, intraday and interday precisions and recoveries were evaluated. The obtained LOD values of α-amanitin and β-amanitin were 1ng/mL and of muscarine 0.09ng/mL. The intraday and interday precisions of human urine spiked with α-amanitin (10ng/mL), β-amanitin (10ng/mL) and muscarine (1ng/mL) ranged from 6% to 10% and from 7% to 13%, respectively. The developed method was proved to be a relevant tool for the simultaneous determination of the studied mushroom toxins in human urine after mushroom poisoning. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Detection and Segmentation of Vine Canopy in Ultra-High Spatial Resolution RGB Imagery Obtained from Unmanned Aerial Vehicle (UAV: A Case Study in a Commercial Vineyard

Directory of Open Access Journals (Sweden)

Carlos Poblete-Echeverría

2017-03-01

Full Text Available The use of Unmanned Aerial Vehicles (UAVs in viticulture permits the capture of aerial Red-Green-Blue (RGB images with an ultra-high spatial resolution. Recent studies have demonstrated that RGB images can be used to monitor spatial variability of vine biophysical parameters. However, for estimating these parameters, accurate and automated segmentation methods are required to extract relevant information from RGB images. Manual segmentation of aerial images is a laborious and time-consuming process. Traditional classification methods have shown satisfactory results in the segmentation of RGB images for diverse applications and surfaces, however, in the case of commercial vineyards, it is necessary to consider some particularities inherent to canopy size in the vertical trellis systems (VSP such as shadow effect and different soil conditions in inter-rows (mixed information of soil and weeds. Therefore, the objective of this study was to compare the performance of four classification methods (K-means, Artificial Neural Networks (ANN, Random Forest (RForest and Spectral Indices (SI to detect canopy in a vineyard trained on VSP. Six flights were carried out from post-flowering to harvest in a commercial vineyard cv. Carménère using a low-cost UAV equipped with a conventional RGB camera. The results show that the ANN and the simple SI method complemented with the Otsu method for thresholding presented the best performance for the detection of the vine canopy with high overall accuracy values for all study days. Spectral indices presented the best performance in the detection of Plant class (Vine canopy with an overall accuracy of around 0.99. However, considering the performance pixel by pixel, the Spectral indices are not able to discriminate between Soil and Shadow class. The best performance in the classification of three classes (Plant, Soil, and Shadow of vineyard RGB images, was obtained when the SI values were used as input data in trained

First Experimental Impulse-Radio Ultra-Wideband Transmission Under the Russian Spectral Emission Mask

DEFF Research Database (Denmark)

Grakhova, Elizaveta P.; Rommel, Simon; Jurado-Navas, Antonio

2016-01-01

Ultra-wideband impulse-radio wireless transmission under the stringent conditions and complex shape of the Russian spectral emission mask is experimentally demonstrated for the first time. Transmission of 1Gbit/s and 1.25Gbit/s signals over distances of 6m and 3m is achieved with a BER below 3.8×10-3....

Integration of ultra-high field MRI and histology for connectome based research of brain disorders

Directory of Open Access Journals (Sweden)

Shan eYang

2013-09-01

Full Text Available Ultra-high field magnetic resonance imaging (MRI became increasingly relevant for in vivo neuroscientific research because of improved spatial resolutions. However, this is still the unchallenged domain of histological studies, which long played an important role in the investigation of neuropsychiatric disorders. While the field of biological psychiatry strongly advanced on macroscopic levels, current developments are rediscovering the richness of immunohistological information when attempting a multi-level systematic approach to brain function and dysfunction. For most studies, histology sections lost information on three-dimensional reconstructions. Translating histological sections to 3D-volumes would thus not only allow for multi-stain and multi-subject alignment in post mortem data, but also provide a crucial step in big data initiatives involving the network analyses currently performed with in vivo MRI. We therefore investigated potential pitfalls during integration of MR and histological information where no additional blockface information is available. We demonstrated that strengths and requirements from both methods seem to be ideally merged at a spatial resolution of 200 μm. However, the success of this approach is heavily dependent on choices of hardware, sequence and reconstruction. We provide a fully automated pipeline that optimizes histological 3D reconstructions, providing a potentially powerful solution not only for primary human post mortem research institutions in neuropsychiatric research, but also to help alleviate the massive workloads in neuroanatomical atlas initiatives. We further demonstrate (for the first time the feasibility and quality of ultra-high spatial resolution (150 µm isotopic imaging of the entire human brain MRI at 7T, offering new opportunities for analyses on MR-derived information.

Set-up of a high-resolution 300 mK atomic force microscope in an ultra-high vacuum compatible {sup 3}He/10 T cryostat

Energy Technology Data Exchange (ETDEWEB)

Allwörden, H. von; Ruschmeier, K.; Köhler, A.; Eelbo, T.; Schwarz, A., E-mail: aschwarz@physnet.uni-hamburg.de; Wiesendanger, R. [Department of Physics, University of Hamburg, Jungiusstrasse 11, 20355 Hamburg (Germany)

2016-07-15

The design of an atomic force microscope with an all-fiber interferometric detection scheme capable of atomic resolution at about 500 mK is presented. The microscope body is connected to a small pumped {sup 3}He reservoir with a base temperature of about 300 mK. The bakeable insert with the cooling stage can be moved from its measurement position inside the bore of a superconducting 10 T magnet into an ultra-high vacuum chamber, where the tip and sample can be exchanged in situ. Moreover, single atoms or molecules can be evaporated onto a cold substrate located inside the microscope. Two side chambers are equipped with standard surface preparation and surface analysis tools. The performance of the microscope at low temperatures is demonstrated by resolving single Co atoms on Mn/W(110) and by showing atomic resolution on NaCl(001).

High-resolution grazing-incidence grating spectrometer for temperature measurements of low-Z ions emitting in the 100-300 Å spectral banda)

Science.gov (United States)

Widmann, K.; Beiersdorfer, P.; Magee, E. W.; Boyle, D. P.; Kaita, R.; Majeski, R.

2014-11-01

We have constructed a high-resolution grazing-incidence spectrometer designed for measuring the ion temperature of low-Z elements, such as Li+ or Li2 +, which radiate near 199 Å and 135 Å, respectively. Based on measurements at the Livermore Electron Beam Ion Trap we have shown that the instrumental resolution is better than 48 mÅ at the 200 Å setting and better than 40 mÅ for the 135-Å range. Such a high spectral resolution corresponds to an instrumental limit for line-width based temperature measurements of about 45 eV for the 199 Å Li+ and 65 eV for the 135 Å Li2 + lines. Recently obtained survey spectra from the Lithium Tokamak Experiment at the Princeton Plasma Physics Laboratory show the presence of these lithium emission lines and the expected core ion temperature of approximately 70 eV is sufficiently high to demonstrate the feasibility of utilizing our high-resolution spectrometer as an ion-temperature diagnostic.

High spatio-temporal resolution pollutant measurements of on-board vehicle emissions using ultra-fast response gas analyzers

Directory of Open Access Journals (Sweden)

M. Irwin

2018-06-01

Full Text Available Existing ultra-fast response engine exhaust emissions analyzers have been adapted for on-board vehicle use combined with GPS data. We present, for the first time, how high spatio-temporal resolution data products allow transient features associated with internal combustion engines to be examined in detail during on-road driving. Such data are both useful to examine the circumstances leading to high emissions, and reveals the accurate position of urban air quality hot spots as deposited by the candidate vehicle, useful for source attribution and dispersion modelling. The fast response time of the analyzers, which results in 100 Hz data, makes accurate time-alignment with the vehicle's engine control unit (ECU signals possible. This enables correlation with transient air fuel ratio, engine speed, load, and other engine parameters, which helps to explain the causes of the emissions spikes that portable emissions measurement systems (PEMS and conventional slow response analyzers would miss or smooth out due to mixing within their sampling systems. The data presented is from NO and NOx analyzers, but other fast analyzers (e.g. total hydrocarbons (THC, CO and CO2 can be used similarly. The high levels of NOx pollution associated with accelerating on entry ramps to motorways, driving over speed bumps, accelerating away from traffic lights, are explored in detail. The time-aligned ultra-fast analyzers offer unique insight allowing more accurate quantification and better interpretation of engine and driver activity and the associated emissions impact on local air quality.

Iterative Frequency-Domain Channel Estimation and Equalization for Ultra-Wideband Systems with Short Cyclic Prefix

Directory of Open Access Journals (Sweden)

Salim Bahçeci

2010-01-01

Full Text Available In impulse radio ultra-wideband (IR-UWB systems where the channel lengths are on the order of a few hundred taps, conventional use of frequency-domain (FD processing for channel estimation and equalization may not be feasible because the need to add a cyclic prefix (CP to each block causes a significant reduction in the spectral efficiency. On the other hand, using no or short CP causes the interblock interference (IBI and thus degradation in the receiver performance. Therefore, in order to utilize FD receiver processing UWB systems without a significant loss in the spectral efficiency and the performance, IBI cancellation mechanisms are needed in both the channel estimation and equalization operations. For this reason, in this paper, we consider the joint FD channel estimation and equalization for IR-UWB systems with short cyclic prefix (CP and propose a novel iterative receiver employing soft IBI estimation and cancellation within both its FD channel estimator and FD equalizer components. We show by simulation results that the proposed FD receiver attains performances close to that of the full CP case in both line-of-sight (LOS and non-line-of-sight (NLOS UWB channels after only a few iterations.

Probing surface plasmons in individual Ag nanoparticles in the ultra-violet spectral regime.

Science.gov (United States)

Chu, Ming-Wen; Sharma, Pradeep; Chang, Ching-Pin; Liou, Sz Chian; Tsai, Kun-Tong; Wang, Juen-Kai; Wang, Yuh-Lin; Chen, Cheng Hsuan

2009-06-10

Previous investigations of surface plasmons in Ag largely focused on their excitations in the visible spectral regime. Using scanning transmission electron microscopy with an electron beam of 0.2 nm in conjunction with electron energy-loss spectroscopy, we spectrally and spatially probe the surface plasmons in individual Ag nanoparticles (approximately 30 nm), grown on Si, in the ultra-violet spectral regime. The nanomaterials show respective sharp and broad surface-plasmon resonances at approximately 3.5 eV (approximately 355 nm) and approximately 7.0 eV (approximately 177 nm), and the correlated spectral calculations established their multipolar characteristics. The near-field distributions of the surface plasmons on the nanoparticles were also mapped out, revealing the predominant dipolar nature of the 3.5 eV excitation with obvious near-field enhancements at one end of the nano-object. The unveiled near-field enhancements have potential applications in plasmonics and molecular sensing.

Probing surface plasmons in individual Ag nanoparticles in the ultra-violet spectral regime

International Nuclear Information System (INIS)

Chu, M-W; Chang, C-P; Liou, S C; Wang, J-K; Chen, C H; Sharma, Pradeep; Tsai, K-T; Wang, Y-L

2009-01-01

Previous investigations of surface plasmons in Ag largely focused on their excitations in the visible spectral regime. Using scanning transmission electron microscopy with an electron beam of 0.2 nm in conjunction with electron energy-loss spectroscopy, we spectrally and spatially probe the surface plasmons in individual Ag nanoparticles (∼30 nm), grown on Si, in the ultra-violet spectral regime. The nanomaterials show respective sharp and broad surface-plasmon resonances at ∼3.5 eV (∼355 nm) and ∼7.0 eV (∼177 nm), and the correlated spectral calculations established their multipolar characteristics. The near-field distributions of the surface plasmons on the nanoparticles were also mapped out, revealing the predominant dipolar nature of the 3.5 eV excitation with obvious near-field enhancements at one end of the nano-object. The unveiled near-field enhancements have potential applications in plasmonics and molecular sensing.

New ultra metal-poor stars from SDSS: follow-up GTC medium-resolution spectroscopy

Science.gov (United States)

Aguado, D. S.; Allende Prieto, C.; González Hernández, J. I.; Rebolo, R.; Caffau, E.

2017-07-01

Context. The first generation of stars formed in the Galaxy left behind the chemical signatures of their nucleosynthesis in the interstellar medium, visible today in the atmospheres of low-mass stars that formed afterwards. Sampling the chemistry of those low-mass provides insight into the first stars. Aims: We aim to increase the samples of stars with extremely low metal abundances, identifying ultra metal-poor stars from spectra with modest spectral resolution and signal-to-noise ratio (S/N). Achieving this goal involves deriving reliable metallicities and carbon abundances from such spectra. Methods: We carry out follow-up observations of faint, V > 19, metal-poor candidates selected from SDSS spectroscopy and observed with the Optical System for Imaging and low-Intermediate-Resolution Integrated Spectroscopy (OSIRIS) at GTC. The SDSS and follow-up OSIRIS spectra were analyzed using the FERRE code to derive effective temperatures, surface gravities, metallicities and carbon abundances. In addition, a well-known extremely metal-poor star has been included in our sample to calibrate the analysis methodology. Results: We observed and analyzed five metal-poor candidates from modest-quality SDSS spectra. All stars in our sample have been confirmed as extremely metal-poor stars, in the [Fe/H] Palma. Programme ID GTC2E-16A and ID GTC65-16B.

Ultra-high performance liquid chromatography tandem high-resolution mass spectrometry study of tricyclazole photodegradation products in water.

Science.gov (United States)

Gosetti, Fabio; Chiuminatto, Ugo; Mazzucco, Eleonora; Mastroianni, Rita; Bolfi, Bianca; Marengo, Emilio

2015-06-01

This paper reports the study of the photodegradation reactions that tricyclazole can naturally undergo, under the action of sunlight, in aqueous solutions of standard tricyclazole and of the commercial BEAM(TM) formulation. The analyses are carried out by ultra-high performance liquid chromatography technique coupled with high-resolution tandem mass spectrometry. Analysis of both tricyclazole and BEAM(TM) water solutions undergone to hydrolysis does not evidence new chromatographic peaks with respect to the not treated solutions. On the contrary, analysis of the same samples subjected to sunlight irradiation shows a decreased intensity of tricyclazole signal and the presence of new chromatographic peaks. Two photodegradation products of tricyclazole have been identified, one of which has been also quantified, being the commercial standard available. The pattern is similar for the solutions of the standard fungicide and of the BEAM(TM) formulation. The results obtained from eco-toxicological tests show that toxicity of tricyclazole standard solutions is greater than that of the irradiated ones, whereas toxicity levels of all the BEAM(TM) solutions investigated (non-irradiated, irradiated, and hydrolyzed) are comparable and lower than those shown by tricyclazole standard solutions. Experiments performed in paddy water solution show that there is no difference in the degradation products formed.

Accurate atmospheric parameters at moderate resolution using spectral indices: Preliminary application to the marvels survey

International Nuclear Information System (INIS)

Ghezzi, Luan; Da Costa, Luiz N.; Maia, Marcio A. G.; Ogando, Ricardo L. C.; Dutra-Ferreira, Letícia; Lorenzo-Oliveira, Diego; Porto de Mello, Gustavo F.; Santiago, Basílio X.; De Lee, Nathan; Lee, Brian L.; Ge, Jian; Wisniewski, John P.; González Hernández, Jonay I.; Stassun, Keivan G.; Cargile, Phillip; Pepper, Joshua; Fleming, Scott W.; Schneider, Donald P.; Mahadevan, Suvrath; Wang, Ji

2014-01-01

Studies of Galactic chemical, and dynamical evolution in the solar neighborhood depend on the availability of precise atmospheric parameters (effective temperature T eff , metallicity [Fe/H], and surface gravity log g) for solar-type stars. Many large-scale spectroscopic surveys operate at low to moderate spectral resolution for efficiency in observing large samples, which makes the stellar characterization difficult due to the high degree of blending of spectral features. Therefore, most surveys employ spectral synthesis, which is a powerful technique, but relies heavily on the completeness and accuracy of atomic line databases and can yield possibly correlated atmospheric parameters. In this work, we use an alternative method based on spectral indices to determine the atmospheric parameters of a sample of nearby FGK dwarfs and subgiants observed by the MARVELS survey at moderate resolving power (R ∼ 12,000). To avoid a time-consuming manual analysis, we have developed three codes to automatically normalize the observed spectra, measure the equivalent widths of the indices, and, through a comparison of those with values calculated with predetermined calibrations, estimate the atmospheric parameters of the stars. The calibrations were derived using a sample of 309 stars with precise stellar parameters obtained from the analysis of high-resolution FEROS spectra, permitting the low-resolution equivalent widths to be directly related to the stellar parameters. A validation test of the method was conducted with a sample of 30 MARVELS targets that also have reliable atmospheric parameters derived from the high-resolution spectra and spectroscopic analysis based on the excitation and ionization equilibria method. Our approach was able to recover the parameters within 80 K for T eff , 0.05 dex for [Fe/H], and 0.15 dex for log g, values that are lower than or equal to the typical external uncertainties found between different high-resolution analyses. An additional test

HIGH RESOLUTION LANDCOVER MODELLING WITH PLÉIADES IMAGERY AND DEM DATA IN SUPPORT OF FINE SCALE LANDSCAPE THERMAL MODELLING

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M. Thompson

2017-11-01

Full Text Available In the evaluation of air-borne thermal infrared imaging sensors, the use of simulated spectral infrared scenery is a cost-effective way to provide input to the sensor. The benefit of simulated scenes includes control over parameters governing the spectral and related thermal behaviour of the terrain as well as atmospheric conditions. Such scenes need to have a high degree of radiometric and geometric accuracy, as well as high resolution to account for small objects having different spectral and associated thermal properties. In support of this, innovative use of tri-stereo, ultra-high resolution Pléiades satellite imagery is being used to generated high detail, small scale quantitative terrain surface data to compliment comparable optical data in order to produce detailed urban and rural landscape datasets representative of different landscape features, within which spectrally defined characteristics can be subsequently matched to thermal signatures. Pléiades tri-stereo mode, acquired from the same orbit during the same pass, is particularly favourable for reaching the required metric accuracy because images are radiometrically and geometrically very homogeneous, which allows a very good radiometric matching for relief computation. The tri-stereo approach reduces noise and allows significantly enhanced relief description in landscapes where simple stereo imaging cannot see features, such as in dense urban areas or valley bottoms in steep, mountainous areas. This paper describes the datasets that have been generated for DENEL over the Hartebeespoort Dam region, west of Pretoria, South Africa. The final terrain datasets are generated by integrated modelling of both height and spectral surface characteristics within an object-based modelling environment. This approach provides an operational framework for rapid and highly accurate mapping of building and vegetation structure of wide areas, as is required in support of the evaluation of thermal

Scalable domain decomposition solvers for stochastic PDEs in high performance computing

International Nuclear Information System (INIS)

Desai, Ajit; Pettit, Chris; Poirel, Dominique; Sarkar, Abhijit

2017-01-01

Stochastic spectral finite element models of practical engineering systems may involve solutions of linear systems or linearized systems for non-linear problems with billions of unknowns. For stochastic modeling, it is therefore essential to design robust, parallel and scalable algorithms that can efficiently utilize high-performance computing to tackle such large-scale systems. Domain decomposition based iterative solvers can handle such systems. And though these algorithms exhibit excellent scalabilities, significant algorithmic and implementational challenges exist to extend them to solve extreme-scale stochastic systems using emerging computing platforms. Intrusive polynomial chaos expansion based domain decomposition algorithms are extended here to concurrently handle high resolution in both spatial and stochastic domains using an in-house implementation. Sparse iterative solvers with efficient preconditioners are employed to solve the resulting global and subdomain level local systems through multi-level iterative solvers. We also use parallel sparse matrix–vector operations to reduce the floating-point operations and memory requirements. Numerical and parallel scalabilities of these algorithms are presented for the diffusion equation having spatially varying diffusion coefficient modeled by a non-Gaussian stochastic process. Scalability of the solvers with respect to the number of random variables is also investigated.

Ultra-high temperature direct propulsion

International Nuclear Information System (INIS)

Araj, K.J.; Slovik, G.; Powell, J.R.; Ludewig, H.

1987-01-01

Potential advantages of ultra-high exhaust temperature (3000 K - 4000 K) direct propulsion nuclear rockets are explored. Modifications to the Particle Bed Reactor (PBR) to achieve these temperatures are described. Benefits of ultra-high temperature propulsion are discussed for two missions - orbit transfer (ΔV = 5546 m/s) and interplanetary exploration (ΔV = 20000 m/s). For such missions ultra-high temperatures appear to be worth the additional complexity. Thrust levels are reduced substantially for a given power level, due to the higher enthalpy caused by partial disassociation of the hydrogen propellant. Though technically challenging, it appears potentially feasible to achieve such ultra high temperatures using the PBR

High-Resolution Urban Greenery Mapping for Micro-Climate Modelling Based on 3d City Models

Science.gov (United States)

Hofierka, J.; Gallay, M.; Kaňuk, J.; Šupinský, J.; Šašak, J.

2017-10-01

Urban greenery has various positive micro-climate effects including mitigation of heat islands. The primary root of heat islands in cities is in absorption of solar radiation by the mass of building structures, roads and other solid materials. The absorbed heat is subsequently re-radiated into the surroundings and increases ambient temperatures. The vegetation can stop and absorb most of incoming solar radiation mostly via the photosynthesis and evapotranspiration process. However, vegetation in mild climate of Europe manifests considerable annual seasonality which can also contribute to the seasonal change in the cooling effect of the vegetation on the urban climate. Modern methods of high-resolution mapping and new generations of sensors have brought opportunity to record the dynamics of urban greenery in a high resolution in spatial, spectral, and temporal domains. In this paper, we use the case study of the city of Košice in Eastern Slovakia to demonstrate the methodology of 3D mapping and modelling the urban greenery during one vegetation season in 2016. The purpose of this monitoring is to capture 3D effects of urban greenery on spatial distribution of solar radiation in urban environment. Terrestrial laser scanning was conducted on four selected sites within Košice in ultra-high spatial resolution. The entire study area, which included these four smaller sites, comprised 4 km2 of the central part of the city was flown within a single airborne lidar and photogrammetric mission to capture the upper parts of buildings and vegetation. The acquired airborne data were used to generate a 3D city model and the time series of terrestrial lidar data were integrated with the 3D city model. The results show that the terrestrial and airborne laser scanning techniques can be effectively used to monitor seasonal changes in foliage of trees in order to assess the transmissivity of the canopy for microclimate modelling.

Spectral-domain optical coherence tomography of roth spots.

Science.gov (United States)

Giovinazzo, Jerome; Mrejen, Sarah; Freund, K Bailey

2013-01-01

To describe the retinal findings of subacute bacterial endocarditis, their evolution after treatment, and analysis with spectral-domain optical coherence tomography. Retrospective chart review. A 21-year-old man presented with the sudden onset of a central scotoma in his left eye because of a sub-internal limiting membrane hemorrhage overlying the left fovea. When examined 2 weeks later, Roth spots were noted in his right eye. The patient was immediately referred to his internist and diagnosed with subacute bacterial endocarditis with cultures positive for Streptococcus viridans. He subsequently underwent aortic valve replacement surgery after 4 weeks of intravenous antibiotic therapy. When examined 4 weeks after valve replacement surgery, there was regression of the Roth spots. The present case demonstrates the importance of a funduscopic examination in the early diagnosis and management of subacute bacterial endocarditis. The analysis of Roth spots with spectral-domain optical coherence tomography suggested that they were septic emboli.

Single photon imaging at ultra-high resolution

Energy Technology Data Exchange (ETDEWEB)

Bellazzini, R. [INFN sez. Pisa, Pisa (Italy); Spandre, G. [INFN sez. Pisa, Pisa (Italy)], E-mail: Gloria.Spandre@pi.infn.it; Minuti, M.; Brez, A.; Baldini, L.; Latronico, L.; Omodei, N.; Sgro, C.; Bregeon, J.; Razzano, M.; Pinchera, M. [INFN sez. Pisa, Pisa (Italy); Tremsin, A.; McPhate, J.; Vallerga, J.V.; Siegmund, O. [SSL, Berkeley (United States)

2008-06-11

We present a detection system capable of imaging both single photon/positive ion and multiple coincidence photons/positive ions with extremely high spatial resolution. In this detector the photoelectrons excited by the incoming photons are multiplied by microchannel plate(s) (MCP). The process of multiplication is spatially constrained within an MCP pore, which can be as small as 4 {mu}m for commercially available MCPs. An electron cloud originated by a single photoelectron is then encoded by a pixellated custom analog ASIC consisting of 105 K charge sensitive pixels of 50 {mu}m in size arranged on a hexagonal grid. Each pixel registers the charge with an accuracy of <100 electrons rms. Computation of the event centroid from the readout charges results in an accurate event position. A large number of simultaneous photons spatially separated by {approx}0.4 mm can be detected simultaneously allowing multiple coincidence operation for the experiments where a large number of incoming photons/positive ions have to be detected simultaneously. The experimental results prove that the spatial resolution of the readout system itself is {approx}3 {mu}m FWHM enabling detection resolution better than 6 {mu}m for the small pore MCPs. An attractive feature of the detection system is its capability to register the timing of each incoming photon/positive ion (in single photon detection mode) or of the first incoming particle (for the multiple coincidence detection) with an accuracy of {approx}130 ps FWHM. There is also virtually no dark count noise in the detection system making it suitable for low count rate applications.

Initial results of a new generation dual source CT system using only an in-plane comb filter for ultra-high resolution temporal bone imaging.

Science.gov (United States)

Meyer, Mathias; Haubenreisser, Holger; Raupach, Rainer; Schmidt, Bernhard; Lietzmann, Florian; Leidecker, Christianne; Allmendinger, Thomas; Flohr, Thomas; Schad, Lothar R; Schoenberg, Stefan O; Henzler, Thomas

2015-01-01

To prospectively evaluate radiation dose and image quality of a third generation dual-source CT (DSCT) without z-axis filter behind the patient for temporal bone CT. Forty-five patients were either examined on a first, second, or third generation DSCT in an ultra-high-resolution (UHR) temporal bone-imaging mode. On the third generation DSCT system, the tighter focal spot of 0.2 mm(2) removes the necessity for an additional z-axis-filter, leading to an improved z-axis radiation dose efficiency. Images of 0.4 mm were reconstructed using standard filtered-back-projection or iterative reconstruction (IR) technique for previous generations of DSCT and a novel IR algorithm for the third generation DSCT. Radiation dose and image quality were compared between the three DSCT systems. The statistically significantly highest subjective and objective image quality was evaluated for the third generation DSCT when compared to the first or second generation DSCT systems (all p generation examination as compared to the first and second generation DSCT. Temporal bone imaging without z-axis-UHR-filter and a novel third generation IR algorithm allows for significantly higher image quality while lowering effective dose when compared to the first two generations of DSCTs. • Omitting the z-axis-filter allows a reduction in radiation dose of 50% • A smaller focal spot of 0.2 mm (2) significantly improves spatial resolution • Ultra-high-resolution temporal-bone-CT helps to gain diagnostic information of the middle/inner ear.

Multichannel spectral mode of the ALOHA up-conversion interferometer

Science.gov (United States)

Lehmann, L.; Darré, P.; Boulogne, H.; Delage, L.; Grossard, L.; Reynaud, F.

2018-06-01

In this paper, we propose a multichannel spectral configuration of the Astronomical Light Optical Hybrid Analysis (ALOHA) instrument dedicated to high-resolution imaging. A frequency conversion process is implemented in each arm of an interferometer to transfer the astronomical light to a shorter wavelength domain. Exploiting the spectral selectivity of this non-linear optical process, we propose to use a set of independent pump lasers in order to simultaneously study multiple spectral channels. This principle is experimentally demonstrated with a dual-channel configuration as a proof-of-principle.

Resolution enhancement of robust Bayesian pre-stack inversion in the frequency domain

Science.gov (United States)

Yin, Xingyao; Li, Kun; Zong, Zhaoyun

2016-10-01

AVO/AVA (amplitude variation with an offset or angle) inversion is one of the most practical and useful approaches to estimating model parameters. So far, publications on AVO inversion in the Fourier domain have been quite limited in view of its poor stability and sensitivity to noise compared with time-domain inversion. For the resolution and stability of AVO inversion in the Fourier domain, a novel robust Bayesian pre-stack AVO inversion based on the mixed domain formulation of stationary convolution is proposed which could solve the instability and achieve superior resolution. The Fourier operator will be integrated into the objective equation and it avoids the Fourier inverse transform in our inversion process. Furthermore, the background constraints of model parameters are taken into consideration to improve the stability and reliability of inversion which could compensate for the low-frequency components of seismic signals. Besides, the different frequency components of seismic signals can realize decoupling automatically. This will help us to solve the inverse problem by means of multi-component successive iterations and the convergence precision of the inverse problem could be improved. So, superior resolution compared with the conventional time-domain pre-stack inversion could be achieved easily. Synthetic tests illustrate that the proposed method could achieve high-resolution results with a high degree of agreement with the theoretical model and verify the quality of anti-noise. Finally, applications on a field data case demonstrate that the proposed method could obtain stable inversion results of elastic parameters from pre-stack seismic data in conformity with the real logging data.

ESSENSE: Ultra high resolution spectroscopy for the ESS

International Nuclear Information System (INIS)

Pasini, Stefano; Monkenbusch, Michael; Kozielewski, Tadeusz

2016-01-01

The instrument concept for a very high intensity neutron spin-echo spectrometer with ultimate resolution properties has been developed and submitted as an instrument proposal to ESS. Effective intensity gain factors up to 30 compared to the best current instruments are anticipated. In addition the resolution will be boosted to the technical limits by newly designed superconducting precession solenoids. The intensity gain results from the use of an optimized guide transporting the high flux from the ESS cold moderator on the one side and from the utilization of an extended wavelength frame of 8 Å yielding a multiplication of information collection rate on the other side. The instrument thus enables novel views on soft matter systems ranging from polymers, functional gels and more to to dynamics of biological molecules with relevance for MD development; the employment of new techniques for surface NSE (GINSE) may contribute to new knowledge in tribology and lubrication and other surface phenomena that currently are hampered by low intensity. New developments in “intelligent” polymers as e.g. self-healing, the properties of which depend on molecular mobility and dynamics, require observation at many 100 ns of correlation times with high intensity, which can be made with ESSENSE. (paper)

The EUV dayglow at high spectral resolution

International Nuclear Information System (INIS)

Morrison, M.D.; Bowers, C.W.; Feldman, P.D.; Meier, R.R.

1990-01-01

Rocket observations of the dayglow spectrum of the terrestrial atmosphere between 840 angstrom and 1860 angstrom at 2 angstrom resolution were obtained with a sounding rocket payload flown on January 17, 1985. Additionally, spectra were also obtained using a 0.125-m focal length scanning Ebert-Fastie monochromator covering the wavelength interval of 1150-1550 angstrom at 7 angstrom resolution on this flight and on a sounding rocket flight on August 29, 1983, under similar viewing geometries and solar zenith angles. Three bands of the N 2 c' 4 system are seen clearly resolved in the dayglow. Analysis of high-resolution N 2 Lyman-Birge-Hopfield data shows no anomalous vibrational distribution as has been reported from other observations. The altitude profiles of the observed O and N 2 emissions demonstrate that the MSIS-83 model O and N 2 densities are appropriate for the conditions of both the 1983 and 1985 rocket flights. A reduction of a factor of 2 in the model O 2 density is required for both flights to reproduce the low-altitude atomic oxygen emission profiles. The volume excitation rates calculated using the Hinteregger et al. (1981) SC number-sign 21REFW solar reference spectrum and the photoelectron flux model of Strickland and Meier (1982) need to be scaled upward by a factor of 1.4 for both fights to match the observations

High spatial and spectral resolution measurements of Jupiter's auroral regions using Gemini-North-TEXES

Science.gov (United States)

Sinclair, J. A.; Orton, G. S.; Greathouse, T. K.; Lacy, J.; Giles, R.; Fletcher, L. N.; Vogt, M.; Irwin, P. G.

2017-12-01

Jupiter exhibits auroral emission at a multitude of wavelengths. Auroral emission at X-ray, ultraviolet and near-infrared wavelengths demonstrate the precipitation of ion and electrons in Jupiter's upper atmosphere, at altitudes exceeding 250 km above the 1-bar level. Enhanced mid-infrared emission of CH4, C2H2, C2H4 and further hydrocarbons is also observed coincident with Jupiter's auroral regions. Retrieval analyses of infrared spectra from IRTF-TEXES (Texas Echelon Cross Echelle Spectrograph on NASA's Infrared Telescope Facility) indicate strong heating at the 1-mbar level and evidence of ion-neutral chemistry, which enriches the abundances of unsaturated hydrocarbons (Sinclair et al., 2017b, doi:10.1002/2017GL073529, Sinclair et al., 2017c (under review)). The extent to which these phenomena in the stratosphere are correlated and coupled physically with the shorter-wavelength auroral emission originating from higher altitudes has been a challenge due to the limited spatial resolution available on the IRTF. Smaller-scale features observed in the near-infrared and ultraviolet emission, such as the main `oval', transient `swirls' and dusk-active regions within the main oval (e.g. Stallard et al., 2014, doi:10.1016/j/Icarus.2015.12.044, Nichols et al., 2017, doi: 10.1002/2017GL073029) are potentially being blurred in the mid-infrared by the diffraction-limited resolution (0.7") of IRTF's 3-metre primary aperture. However, on March 17-19th 2017, we obtained spectral measurements of H2 S(1), CH4, C2H2, C2H4 and C2H6 emission of Jupiter's high latitudes using TEXES on Gemini-North, which has a 8-metre primary aperture. This rare opportunity combines the superior spectral resolving power of TEXES and the high spatial resolution provided by Gemini-North's 8-metre aperture. We will perform a retrieval analyses to determine the 3D distributions of temperature, C2H2, C2H4 and C2H6. The morphology will be compared with near-contemporaneous measurements of H3+ emission from

Atomic resolution structure of the E. coli YajR transporter YAM domain

Energy Technology Data Exchange (ETDEWEB)

Jiang, Daohua [National Laboratory of Macromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101 (China); School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074 (China); Zhao, Yan [National Laboratory of Macromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101 (China); School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027 (China); Fan, Junping; Liu, Xuehui; Wu, Yan; Feng, Wei [National Laboratory of Macromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101 (China); Zhang, Xuejun C., E-mail: zhangc@ibp.ac.cn [National Laboratory of Macromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101 (China)

2014-07-25

Highlights: • We report the crystal structure of the YAM domain of YajR transporter at 1.07 Å. • The YAM dimerization is related to the halogen-dependent high thermal stability. • A belt of poly-pentagonal water molecules was observed in the dimer interface. - Abstract: YajR is an Escherichia coli transporter that belongs to the major facilitator superfamily. Unlike most MFS transporters, YajR contains a carboxyl terminal, cytosolic domain of 67 amino acid residues termed YAM domain. Although it is speculated that the function of this small soluble domain is to regulate the conformational change of the 12-helix transmembrane domain, its precise regulatory role remains unclear. Here, we report the crystal structure of the YAM domain at 1.07-Å resolution, along with its structure determined using nuclear magnetic resonance. Detailed analysis of the high resolution structure revealed a symmetrical dimer in which a belt of well-ordered poly-pentagonal water molecules is embedded. A mutagenesis experiment and a thermal stability assay were used to analyze the putative role of this dimerization in response to changes in halogen concentration.

High-resolution grazing-incidence grating spectrometer for temperature measurements of low-Z ions emitting in the 100–300 Å spectral band

Energy Technology Data Exchange (ETDEWEB)

Widmann, K., E-mail: widmann1@llnl.gov; Beiersdorfer, P.; Magee, E. W. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Boyle, D. P.; Kaita, R.; Majeski, R. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)

2014-11-15

We have constructed a high-resolution grazing-incidence spectrometer designed for measuring the ion temperature of low-Z elements, such as Li{sup +} or Li{sup 2+}, which radiate near 199 Å and 135 Å, respectively. Based on measurements at the Livermore Electron Beam Ion Trap we have shown that the instrumental resolution is better than 48 mÅ at the 200 Å setting and better than 40 mÅ for the 135-Å range. Such a high spectral resolution corresponds to an instrumental limit for line-width based temperature measurements of about 45 eV for the 199 Å Li{sup +} and 65 eV for the 135 Å Li{sup 2+} lines. Recently obtained survey spectra from the Lithium Tokamak Experiment at the Princeton Plasma Physics Laboratory show the presence of these lithium emission lines and the expected core ion temperature of approximately 70 eV is sufficiently high to demonstrate the feasibility of utilizing our high-resolution spectrometer as an ion-temperature diagnostic.

Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner

Science.gov (United States)

Kakinuma, Ryutaro; Moriyama, Noriyuki; Muramatsu, Yukio; Gomi, Shiho; Suzuki, Masahiro; Nagasawa, Hirobumi; Kusumoto, Masahiko; Aso, Tomohiko; Muramatsu, Yoshihisa; Tsuchida, Takaaki; Tsuta, Koji; Maeshima, Akiko Miyagi; Tochigi, Naobumi; Watanabe, Shun-ichi; Sugihara, Naoki; Tsukagoshi, Shinsuke; Saito, Yasuo; Kazama, Masahiro; Ashizawa, Kazuto; Awai, Kazuo; Honda, Osamu; Ishikawa, Hiroyuki; Koizumi, Naoya; Komoto, Daisuke; Moriya, Hiroshi; Oda, Seitaro; Oshiro, Yasuji; Yanagawa, Masahiro; Tomiyama, Noriyuki; Asamura, Hisao

2015-01-01

Purpose The image noise and image quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated and compared with those of conventional high-resolution CT (C-HRCT) scanners. Materials and Methods This study was approved by the institutional review board. A U-HRCT scanner prototype with 0.25 mm x 4 rows and operating at 120 mAs was used. The C-HRCT images were obtained using a 0.5 mm x 16 or 0.5 mm x 64 detector-row CT scanner operating at 150 mAs. Images from both scanners were reconstructed at 0.1-mm intervals; the slice thickness was 0.25 mm for the U-HRCT scanner and 0.5 mm for the C-HRCT scanners. For both scanners, the display field of view was 80 mm. The image noise of each scanner was evaluated using a phantom. U-HRCT and C-HRCT images of 53 images selected from 37 lung nodules were then observed and graded using a 5-point score by 10 board-certified thoracic radiologists. The images were presented to the observers randomly and in a blinded manner. Results The image noise for U-HRCT (100.87 ± 0.51 Hounsfield units [HU]) was greater than that for C-HRCT (40.41 ± 0.52 HU; P < .0001). The image quality of U-HRCT was graded as superior to that of C-HRCT (P < .0001) for all of the following parameters that were examined: margins of subsolid and solid nodules, edges of solid components and pulmonary vessels in subsolid nodules, air bronchograms, pleural indentations, margins of pulmonary vessels, edges of bronchi, and interlobar fissures. Conclusion Despite a larger image noise, the prototype U-HRCT scanner had a significantly better image quality than the C-HRCT scanners. PMID:26352144

Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner.

Directory of Open Access Journals (Sweden)

Ryutaro Kakinuma

Full Text Available The image noise and image quality of a prototype ultra-high-resolution computed tomography (U-HRCT scanner was evaluated and compared with those of conventional high-resolution CT (C-HRCT scanners.This study was approved by the institutional review board. A U-HRCT scanner prototype with 0.25 mm x 4 rows and operating at 120 mAs was used. The C-HRCT images were obtained using a 0.5 mm x 16 or 0.5 mm x 64 detector-row CT scanner operating at 150 mAs. Images from both scanners were reconstructed at 0.1-mm intervals; the slice thickness was 0.25 mm for the U-HRCT scanner and 0.5 mm for the C-HRCT scanners. For both scanners, the display field of view was 80 mm. The image noise of each scanner was evaluated using a phantom. U-HRCT and C-HRCT images of 53 images selected from 37 lung nodules were then observed and graded using a 5-point score by 10 board-certified thoracic radiologists. The images were presented to the observers randomly and in a blinded manner.The image noise for U-HRCT (100.87 ± 0.51 Hounsfield units [HU] was greater than that for C-HRCT (40.41 ± 0.52 HU; P < .0001. The image quality of U-HRCT was graded as superior to that of C-HRCT (P < .0001 for all of the following parameters that were examined: margins of subsolid and solid nodules, edges of solid components and pulmonary vessels in subsolid nodules, air bronchograms, pleural indentations, margins of pulmonary vessels, edges of bronchi, and interlobar fissures.Despite a larger image noise, the prototype U-HRCT scanner had a significantly better image quality than the C-HRCT scanners.

Temporal measurement and analysis of high-resolution spectral signatures of plants and relationships to biophysical characteristics

Science.gov (United States)

Bostater, Charles R., Jr.; Rebbman, Jan; Hall, Carlton; Provancha, Mark; Vieglais, David

1995-11-01

Measurements of temporal reflectance signatures as a function of growing season for sand live oak (Quercus geminata), myrtle oak (Q. myrtifolia, and saw palmetto (Serenoa repens) were collected during a two year study period. Canopy level spectral reflectance signatures, as a function of 252 channels between 368 and 1115 nm, were collected using near nadir viewing geometry and a consistent sun illumination angle. Leaf level reflectance measurements were made in the laboratory using a halogen light source and an environmental optics chamber with a barium sulfate reflectance coating. Spectral measurements were related to several biophysical measurements utilizing optimal passive ambient correlation spectroscopy (OPACS) technique. Biophysical parameters included percent moisture, water potential (MPa), total chlorophyll, and total Kjeldahl nitrogen. Quantitative data processing techniques were used to determine optimal bands based on the utilization of a second order derivative or inflection estimator. An optical cleanup procedure was then employed that computes the double inflection ratio (DIR) spectra for all possible three band combinations normalized to the previously computed optimal bands. These results demonstrate a unique approach to the analysis of high spectral resolution reflectance signatures for estimation of several biophysical measures of plants at the leaf and canopy level from optimally selected bands or bandwidths.

Using Airborne High Spectral Resolution Lidar Data to Evaluate Combined Active Plus Passive Retrievals of Aerosol Extinction Profiles

Science.gov (United States)

Burton, S. P.; Ferrare, R. A.; Hostetler, C. A.; Hair, J. W.; Kittaka, C.; Vaughn, M. A.; Remer, L. A.

2010-01-01

We derive aerosol extinction profiles from airborne and space-based lidar backscatter signals by constraining the retrieval with column aerosol optical thickness (AOT), with no need to rely on assumptions about aerosol type or lidar ratio. The backscatter data were acquired by the NASA Langley Research Center airborne High Spectral Resolution Lidar (HSRL) and by the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) instrument on the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite. The HSRL also simultaneously measures aerosol extinction coefficients independently using the high spectral resolution lidar technique, thereby providing an ideal data set for evaluating the retrieval. We retrieve aerosol extinction profiles from both HSRL and CALIOP attenuated backscatter data constrained with HSRL, Moderate-Resolution Imaging Spectroradiometer (MODIS), and Multiangle Imaging Spectroradiometer column AOT. The resulting profiles are compared with the aerosol extinction measured by HSRL. Retrievals are limited to cases where the column aerosol thickness is greater than 0.2 over land and 0.15 over water. In the case of large AOT, the results using the Aqua MODIS constraint over water are poorer than Aqua MODIS over land or Terra MODIS. The poorer results relate to an apparent bias in Aqua MODIS AOT over water observed in August 2007. This apparent bias is still under investigation. Finally, aerosol extinction coefficients are derived from CALIPSO backscatter data using AOT from Aqua MODIS for 28 profiles over land and 9 over water. They agree with coincident measurements by the airborne HSRL to within +/-0.016/km +/- 20% for at least two-thirds of land points and within +/-0.028/km +/- 20% for at least two-thirds of ocean points.

The spectral cell method in nonlinear earthquake modeling

Science.gov (United States)

Giraldo, Daniel; Restrepo, Doriam

2017-12-01

This study examines the applicability of the spectral cell method (SCM) to compute the nonlinear earthquake response of complex basins. SCM combines fictitious-domain concepts with the spectral-version of the finite element method to solve the wave equations in heterogeneous geophysical domains. Nonlinear behavior is considered by implementing the Mohr-Coulomb and Drucker-Prager yielding criteria. We illustrate the performance of SCM with numerical examples of nonlinear basins exhibiting physically and computationally challenging conditions. The numerical experiments are benchmarked with results from overkill solutions, and using MIDAS GTS NX, a finite element software for geotechnical applications. Our findings show good agreement between the two sets of results. Traditional spectral elements implementations allow points per wavelength as low as PPW = 4.5 for high-order polynomials. Our findings show that in the presence of nonlinearity, high-order polynomials (p ≥ 3) require mesh resolutions above of PPW ≥ 10 to ensure displacement errors below 10%.

Accurate Atmospheric Parameters at Moderate Resolution Using Spectral Indices: Preliminary Application to the MARVELS Survey

Science.gov (United States)

Ghezzi, Luan; Dutra-Ferreira, Letícia; Lorenzo-Oliveira, Diego; Porto de Mello, Gustavo F.; Santiago, Basílio X.; De Lee, Nathan; Lee, Brian L.; da Costa, Luiz N.; Maia, Marcio A. G.; Ogando, Ricardo L. C.; Wisniewski, John P.; González Hernández, Jonay I.; Stassun, Keivan G.; Fleming, Scott W.; Schneider, Donald P.; Mahadevan, Suvrath; Cargile, Phillip; Ge, Jian; Pepper, Joshua; Wang, Ji; Paegert, Martin

2014-12-01

Studies of Galactic chemical, and dynamical evolution in the solar neighborhood depend on the availability of precise atmospheric parameters (effective temperature T eff, metallicity [Fe/H], and surface gravity log g) for solar-type stars. Many large-scale spectroscopic surveys operate at low to moderate spectral resolution for efficiency in observing large samples, which makes the stellar characterization difficult due to the high degree of blending of spectral features. Therefore, most surveys employ spectral synthesis, which is a powerful technique, but relies heavily on the completeness and accuracy of atomic line databases and can yield possibly correlated atmospheric parameters. In this work, we use an alternative method based on spectral indices to determine the atmospheric parameters of a sample of nearby FGK dwarfs and subgiants observed by the MARVELS survey at moderate resolving power (R ~ 12,000). To avoid a time-consuming manual analysis, we have developed three codes to automatically normalize the observed spectra, measure the equivalent widths of the indices, and, through a comparison of those with values calculated with predetermined calibrations, estimate the atmospheric parameters of the stars. The calibrations were derived using a sample of 309 stars with precise stellar parameters obtained from the analysis of high-resolution FEROS spectra, permitting the low-resolution equivalent widths to be directly related to the stellar parameters. A validation test of the method was conducted with a sample of 30 MARVELS targets that also have reliable atmospheric parameters derived from the high-resolution spectra and spectroscopic analysis based on the excitation and ionization equilibria method. Our approach was able to recover the parameters within 80 K for T eff, 0.05 dex for [Fe/H], and 0.15 dex for log g, values that are lower than or equal to the typical external uncertainties found between different high-resolution analyses. An additional test was

Time-domain multiplexed high resolution fiber optics strain sensor system based on temporal response of fiber Fabry-Perot interferometers.

Science.gov (United States)

Chen, Jiageng; Liu, Qingwen; He, Zuyuan

2017-09-04

We developed a multiplexed strain sensor system with high resolution using fiber Fabry-Perot interferometers (FFPI) as sensing elements. The temporal responses of the FFPIs excited by rectangular laser pulses are used to obtain the strain applied on each FFPI. The FFPIs are connected by cascaded couplers and delay fiber rolls for the time-domain multiplexing. A compact optoelectronic system performing closed-loop cyclic interrogation is employed to improve the sensing resolution and the frequency response. In the demonstration experiment, 3-channel strain sensing with resolutions better than 0.1 nε and frequency response higher than 100 Hz is realized.

HIGH RESOLUTION 36 GHz IMAGING OF THE SUPERNOVA REMNANT OF SN 1987A

International Nuclear Information System (INIS)

Potter, T. M.; Staveley-Smith, L.; Zanardo, G.; Ng, C.-Y.; Gaensler, B. M.; Ball, Lewis; Kesteven, M. J.; Manchester, R. N.; Tzioumis, A. K.

2009-01-01

The aftermath of supernova (SN) 1987A continues to provide spectacular insights into the interaction between an SN blastwave and its circumstellar environment. We here present 36 GHz observations from the Australia Telescope Compact Array of the radio remnant of SN 1987A. These new images, taken in 2008 April and 2008 October, substantially extend the frequency range of an ongoing monitoring and imaging program conducted between 1.4 and 20 GHz. Our 36.2 GHz images have a diffraction-limited angular resolution of 0.''3-0.''4, which covers the gap between high resolution, low dynamic range VLBI images of the remnant and low resolution, high dynamic range images at frequencies between 1 and 20 GHz. The radio morphology of the remnant at 36 GHz is an elliptical ring with enhanced emission on the eastern and western sides, similar to that seen previously at lower frequencies. Model fits to the data in the Fourier domain show that the emitting region is consistent with a thick inclined torus of mean radius 0.''85, and a 2008 October flux density of 27 ± 6 mJy at 36.2 GHz. The spectral index for the remnant at this epoch, determined between 1.4 GHz and 36.2 GHz, is α = -0.83. There is tentative evidence for an unresolved central source with flatter spectral index.

Combining pixel and object based image analysis of ultra-high resolution multibeam bathymetry and backscatter for habitat mapping in shallow marine waters

Science.gov (United States)

Ierodiaconou, Daniel; Schimel, Alexandre C. G.; Kennedy, David; Monk, Jacquomo; Gaylard, Grace; Young, Mary; Diesing, Markus; Rattray, Alex

2018-06-01

Habitat mapping data are increasingly being recognised for their importance in underpinning marine spatial planning. The ability to collect ultra-high resolution (cm) multibeam echosounder (MBES) data in shallow waters has facilitated understanding of the fine-scale distribution of benthic habitats in these areas that are often prone to human disturbance. Developing quantitative and objective approaches to integrate MBES data with ground observations for predictive modelling is essential for ensuring repeatability and providing confidence measures for habitat mapping products. Whilst supervised classification approaches are becoming more common, users are often faced with a decision whether to implement a pixel based (PB) or an object based (OB) image analysis approach, with often limited understanding of the potential influence of that decision on final map products and relative importance of data inputs to patterns observed. In this study, we apply an ensemble learning approach capable of integrating PB and OB Image Analysis from ultra-high resolution MBES bathymetry and backscatter data for mapping benthic habitats in Refuge Cove, a temperate coastal embayment in south-east Australia. We demonstrate the relative importance of PB and OB seafloor derivatives for the five broad benthic habitats that dominate the site. We found that OB and PB approaches performed well with differences in classification accuracy but not discernible statistically. However, a model incorporating elements of both approaches proved to be significantly more accurate than OB or PB methods alone and demonstrate the benefits of using MBES bathymetry and backscatter combined for class discrimination.

The fusion of satellite and UAV data: simulation of high spatial resolution band

Science.gov (United States)

Jenerowicz, Agnieszka; Siok, Katarzyna; Woroszkiewicz, Malgorzata; Orych, Agata

2017-10-01

Remote sensing techniques used in the precision agriculture and farming that apply imagery data obtained with sensors mounted on UAV platforms became more popular in the last few years due to the availability of low- cost UAV platforms and low- cost sensors. Data obtained from low altitudes with low- cost sensors can be characterised by high spatial and radiometric resolution but quite low spectral resolution, therefore the application of imagery data obtained with such technology is quite limited and can be used only for the basic land cover classification. To enrich the spectral resolution of imagery data acquired with low- cost sensors from low altitudes, the authors proposed the fusion of RGB data obtained with UAV platform with multispectral satellite imagery. The fusion is based on the pansharpening process, that aims to integrate the spatial details of the high-resolution panchromatic image with the spectral information of lower resolution multispectral or hyperspectral imagery to obtain multispectral or hyperspectral images with high spatial resolution. The key of pansharpening is to properly estimate the missing spatial details of multispectral images while preserving their spectral properties. In the research, the authors presented the fusion of RGB images (with high spatial resolution) obtained with sensors mounted on low- cost UAV platforms and multispectral satellite imagery with satellite sensors, i.e. Landsat 8 OLI. To perform the fusion of UAV data with satellite imagery, the simulation of the panchromatic bands from RGB data based on the spectral channels linear combination, was conducted. Next, for simulated bands and multispectral satellite images, the Gram-Schmidt pansharpening method was applied. As a result of the fusion, the authors obtained several multispectral images with very high spatial resolution and then analysed the spatial and spectral accuracies of processed images.

The "+" for CRIRES: enabling better science at infrared wavelength and high spectral resolution at the ESO VLT

Science.gov (United States)

Dorn, Reinhold J.; Follert, Roman; Bristow, Paul; Cumani, Claudio; Eschbaumer, Siegfried; Grunhut, Jason; Haimerl, Andreas; Hatzes, Artie; Heiter, Ulrike; Hinterschuster, Renate; Ives, Derek J.; Jung, Yves; Kerber, Florian; Klein, Barbara; Lavaila, Alexis; Lizon, Jean Louis; Löwinger, Tom; Molina-Conde, Ignacio; Nicholson, Belinda; Marquart, Thomas; Oliva, Ernesto; Origlia, Livia; Pasquini, Luca; Paufique, Jérôme; Piskunov, Nikolai; Reiners, Ansgar; Seemann, Ulf; Stegmeier, Jörg; Stempels, Eric; Tordo, Sebastien

2016-08-01

The adaptive optics (AO) assisted CRIRES instrument is an IR (0.92 - 5.2 μm) high-resolution spectrograph was in operation from 2006 to 2014 at the Very Large Telescope (VLT) observatory. CRIRES was a unique instrument, accessing a parameter space (wavelength range and spectral resolution) up to now largely uncharted. It consisted of a single-order spectrograph providing long-slit (40 arcsecond) spectroscopy with a resolving power up to R=100 000. However the setup was limited to a narrow, single-shot, spectral range of about 1/70 of the central wavelength, resulting in low observing efficiency for many scientific programmes requiring a broad spectral coverage. The CRIRES upgrade project, CRIRES+, transforms this VLT instrument into a cross-dispersed spectrograph to increase the simultaneously covered wavelength range by a factor of ten. A new and larger detector focal plane array of three Hawaii 2RG detectors with 5.3 μm cut-off wavelength will replace the existing detectors. For advanced wavelength calibration, custom-made absorption gas cells and an etalon system will be added. A spectro-polarimetric unit will allow the recording of circular and linear polarized spectra. This upgrade will be supported by dedicated data reduction software allowing the community to take full advantage of the new capabilities offered by CRIRES+. CRIRES+ has now entered its assembly and integration phase and will return with all new capabilities by the beginning of 2018 to the Very Large Telescope in Chile. This article will provide the reader with an update of the current status of the instrument as well as the remaining steps until final installation at the Paranal Observatory.

Research and Development of a portable microfocus x-ray system capable of providing ultra-high resolutions images of improvised explosive devices

International Nuclear Information System (INIS)

Korkala, G.

1989-01-01

The utilization of x-ray screening has long been a recognized valuable tool as a means to evaluate and identify suspect articles for possible improvised explosive devices. Recent bombings indicate an increase in technical sophistication by the terrorist which demand additional means to further the possibility of detecting these devices before they reach their target or detonate. This paper discusses history of the use of x-ray and the design parameters of a portable micro-focus x-ray system capable of providing ultra high resolution radiographs as well as being able to be used with additional state-of-the-art imaging systems

Ultra-high resolution coded wavefront sensor

KAUST Repository

Wang, Congli; Dun, Xiong; Fu, Qiang; Heidrich, Wolfgang

2017-01-01

Wavefront sensors and more general phase retrieval methods have recently attracted a lot of attention in a host of application domains, ranging from astronomy to scientific imaging and microscopy. In this paper, we introduce a new class of sensor

A New Pansharpening Method Based on Spatial and Spectral Sparsity Priors.

Science.gov (United States)

He, Xiyan; Condat, Laurent; Bioucas-Diaz, Jose; Chanussot, Jocelyn; Xia, Junshi

2014-06-27

The development of multisensor systems in recent years has led to great increase in the amount of available remote sensing data. Image fusion techniques aim at inferring high quality images of a given area from degraded versions of the same area obtained by multiple sensors. This paper focuses on pansharpening, which is the inference of a high spatial resolution multispectral image from two degraded versions with complementary spectral and spatial resolution characteristics: a) a low spatial resolution multispectral image; and b) a high spatial resolution panchromatic image. We introduce a new variational model based on spatial and spectral sparsity priors for the fusion. In the spectral domain we encourage low-rank structure, whereas in the spatial domain we promote sparsity on the local differences. Given the fact that both panchromatic and multispectral images are integrations of the underlying continuous spectra using different channel responses, we propose to exploit appropriate regularizations based on both spatial and spectral links between panchromatic and the fused multispectral images. A weighted version of the vector Total Variation (TV) norm of the data matrix is employed to align the spatial information of the fused image with that of the panchromatic image. With regard to spectral information, two different types of regularization are proposed to promote a soft constraint on the linear dependence between the panchromatic and the fused multispectral images. The first one estimates directly the linear coefficients from the observed panchromatic and low resolution multispectral images by Linear Regression (LR) while the second one employs the Principal Component Pursuit (PCP) to obtain a robust recovery of the underlying low-rank structure. We also show that the two regularizers are strongly related. The basic idea of both regularizers is that the fused image should have low-rank and preserve edge locations. We use a variation of the recently proposed

High-emulation mask recognition with high-resolution hyperspectral video capture system

Science.gov (United States)

Feng, Jiao; Fang, Xiaojing; Li, Shoufeng; Wang, Yongjin

2014-11-01

We present a method for distinguishing human face from high-emulation mask, which is increasingly used by criminals for activities such as stealing card numbers and passwords on ATM. Traditional facial recognition technique is difficult to detect such camouflaged criminals. In this paper, we use the high-resolution hyperspectral video capture system to detect high-emulation mask. A RGB camera is used for traditional facial recognition. A prism and a gray scale camera are used to capture spectral information of the observed face. Experiments show that mask made of silica gel has different spectral reflectance compared with the human skin. As multispectral image offers additional spectral information about physical characteristics, high-emulation mask can be easily recognized.

A novel femtosecond-gated, high-resolution, frequency-shifted shearing interferometry technique for probing pre-plasma expansion in ultra-intense laser experiments

Energy Technology Data Exchange (ETDEWEB)

Feister, S., E-mail: feister.7@osu.edu; Orban, C. [Department of Physics, The Ohio State University, Columbus, Ohio 43210 (United States); Innovative Scientific Solutions, Inc., Dayton, Ohio 45459 (United States); Nees, J. A. [Innovative Scientific Solutions, Inc., Dayton, Ohio 45459 (United States); Center for Ultra-Fast Optical Science, University of Michigan, Ann Arbor, Michigan 48109 (United States); Morrison, J. T. [Fellow, National Research Council, Washington, D.C. 20001 (United States); Frische, K. D. [Innovative Scientific Solutions, Inc., Dayton, Ohio 45459 (United States); Chowdhury, E. A. [Department of Physics, The Ohio State University, Columbus, Ohio 43210 (United States); Intense Energy Solutions, LLC., Plain City, Ohio 43064 (United States); Roquemore, W. M. [Air Force Research Laboratory, Dayton, Ohio 45433 (United States)

2014-11-15

Ultra-intense laser-matter interaction experiments (>10{sup 18} W/cm{sup 2}) with dense targets are highly sensitive to the effect of laser “noise” (in the form of pre-pulses) preceding the main ultra-intense pulse. These system-dependent pre-pulses in the nanosecond and/or picosecond regimes are often intense enough to modify the target significantly by ionizing and forming a plasma layer in front of the target before the arrival of the main pulse. Time resolved interferometry offers a robust way to characterize the expanding plasma during this period. We have developed a novel pump-probe interferometry system for an ultra-intense laser experiment that uses two short-pulse amplifiers synchronized by one ultra-fast seed oscillator to achieve 40-fs time resolution over hundreds of nanoseconds, using a variable delay line and other techniques. The first of these amplifiers acts as the pump and delivers maximal energy to the interaction region. The second amplifier is frequency shifted and then frequency doubled to generate the femtosecond probe pulse. After passing through the laser-target interaction region, the probe pulse is split and recombined in a laterally sheared Michelson interferometer. Importantly, the frequency shift in the probe allows strong plasma self-emission at the second harmonic of the pump to be filtered out, allowing plasma expansion near the critical surface and elsewhere to be clearly visible in the interferograms. To aid in the reconstruction of phase dependent imagery from fringe shifts, three separate 120° phase-shifted (temporally sheared) interferograms are acquired for each probe delay. Three-phase reconstructions of the electron densities are then inferred by Abel inversion. This interferometric system delivers precise measurements of pre-plasma expansion that can identify the condition of the target at the moment that the ultra-intense pulse arrives. Such measurements are indispensable for correlating laser pre-pulse measurements

Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina

Science.gov (United States)

Zhang, Yan; Rha, Jungtae; Jonnal, Ravi S.; Miller, Donald T.

2005-06-01

Although optical coherence tomography (OCT) can axially resolve and detect reflections from individual cells, there are no reports of imaging cells in the living human retina using OCT. To supplement the axial resolution and sensitivity of OCT with the necessary lateral resolution and speed, we developed a novel spectral domain OCT (SD-OCT) camera based on a free-space parallel illumination architecture and equipped with adaptive optics (AO). Conventional flood illumination, also with AO, was integrated into the camera and provided confirmation of the focus position in the retina with an accuracy of ±10.3 μm. Short bursts of narrow B-scans (100x560 μm) of the living retina were subsequently acquired at 500 Hz during dynamic compensation (up to 14 Hz) that successfully corrected the most significant ocular aberrations across a dilated 6 mm pupil. Camera sensitivity (up to 94 dB) was sufficient for observing reflections from essentially all neural layers of the retina. Signal-to-noise of the detected reflection from the photoreceptor layer was highly sensitive to the level of cular aberrations and defocus with changes of 11.4 and 13.1 dB (single pass) observed when the ocular aberrations (astigmatism, 3rd order and higher) were corrected and when the focus was shifted by 200 μm (0.54 diopters) in the retina, respectively. The 3D resolution of the B-scans (3.0x3.0x5.7 μm) is the highest reported to date in the living human eye and was sufficient to observe the interface between the inner and outer segments of individual photoreceptor cells, resolved in both lateral and axial dimensions. However, high contrast speckle, which is intrinsic to OCT, was present throughout the AO parallel SD-OCT B-scans and obstructed correlating retinal reflections to cell-sized retinal structures.

High Resolution Energetic X-ray Imager (HREXI)

Science.gov (United States)

Grindlay, Jonathan

We propose to design and build the first imaging hard X-ray detector system that incorporates 3D stacking of closely packed detector readouts in finely-spaced imaging arrays with their required data processing and control electronics. In virtually all imaging astronomical detectors, detector readout is done with flex connectors or connections that are not vertical but rather horizontal , requiring loss of focal plane area. For high resolution pixel detectors needed for high speed event-based X-ray imaging, from low energy applications (CMOS) with focusing X-ray telescopes, to hard X-ray applications with pixelated CZT for large area coded aperture telescopes, this new detector development offers great promise. We propose to extend our previous and current APRA supported ProtoEXIST program that has developed the first large area imaging CZT detectors and demonstrated their astrophysical capabilities on two successful balloon flight to a next generation High Resolution Energetic X-ray Imager (HREXI), which would incorporate microvia technology for the first time to connect the readout ASIC on each CZT crystal directly to its control and data processing system. This 3-dimensional stacking of detector and readout/control system means that large area (>2m2) imaging detector planes for a High Resolution Wide-field hard X-ray telescope can be built with initially greatly reduced detector gaps and ultimately with no gaps. This increases detector area, efficiency, and simplicity of detector integration. Thus higher sensitivity wide-field imagers will be possible at lower cost. HREXI will enable a post-Swift NASA mission such as the EREXS concept proposed to PCOS to be conducted as a future MIDEX mission. This mission would conduct a high resolution (<2 arcmin) , broad band (5 200 keV) hard X-ray survey of black holes on all scales with ~10X higher sensitivity than Swift. In the current era of Time Domain Astrophysics, such a survey capability, in conjunction with a n

Determination of channel temperature for AlGaN/GaN HEMTs by high spectral resolution micro-Raman spectroscopy

International Nuclear Information System (INIS)

Zhang Guangchen; Feng Shiwei; Li Jingwan; Guo Chunsheng; Zhao Yan

2012-01-01

Channel temperature determinations of AlGaN/GaN high electron mobility transistors (HEMTs) by high spectral resolution micro-Raman spectroscopy are proposed. The temperature dependence of the E2 phonon frequency of GaN material is calibrated by using a JYT-64000 micro-Raman system. By using the Lorentz fitting method, the measurement uncertainty for the Raman phonon frequency of ±0.035 cm −1 is achieved, corresponding to a temperature accuracy of ±3.2 °C for GaN material, which is the highest temperature resolution in the published works. The thermal resistance of the tested AlGaN/GaN HEMT sample is 22.8 °C/W, which is in reasonably good agreement with a three dimensional heat conduction simulation. The difference among the channel temperatures obtained by micro-Raman spectroscopy, the pulsed electrical method and the infrared image method are also investigated quantificationally. (semiconductor devices)

A HIGH-RESOLUTION, MULTI-EPOCH SPECTRAL ATLAS OF PECULIAR STARS INCLUDING RAVE, GAIA , AND HERMES WAVELENGTH RANGES

International Nuclear Information System (INIS)

Tomasella, Lina; Munari, Ulisse; Zwitter, Tomaz

2010-01-01

We present an Echelle+CCD, high signal-to-noise ratio, high-resolution (R = 20,000) spectroscopic atlas of 108 well-known objects representative of the most common types of peculiar and variable stars. The wavelength interval extends from 4600 to 9400 A and includes the RAVE, Gaia, and HERMES wavelength ranges. Multi-epoch spectra are provided for the majority of the observed stars. A total of 425 spectra of peculiar stars, which were collected during 56 observing nights between 1998 November and 2002 August, are presented. The spectra are given in FITS format and heliocentric wavelengths, with accurate subtraction of both the sky background and the scattered light. Auxiliary material useful for custom applications (telluric dividers, spectrophotometric stars, flat-field tracings) is also provided. The atlas aims to provide a homogeneous database of the spectral appearance of stellar peculiarities, a tool useful both for classification purposes and inter-comparison studies. It could also serve in the planning and development of automated classification algorithms designed for RAVE, Gaia, HERMES, and other large-scale spectral surveys. The spectrum of XX Oph is discussed in some detail as an example of the content of the present atlas.

A domain decomposition method for pseudo-spectral electromagnetic simulations of plasmas

International Nuclear Information System (INIS)

Vay, Jean-Luc; Haber, Irving; Godfrey, Brendan B.

2013-01-01

Pseudo-spectral electromagnetic solvers (i.e. representing the fields in Fourier space) have extraordinary precision. In particular, Haber et al. presented in 1973 a pseudo-spectral solver that integrates analytically the solution over a finite time step, under the usual assumption that the source is constant over that time step. Yet, pseudo-spectral solvers have not been widely used, due in part to the difficulty for efficient parallelization owing to global communications associated with global FFTs on the entire computational domains. A method for the parallelization of electromagnetic pseudo-spectral solvers is proposed and tested on single electromagnetic pulses, and on Particle-In-Cell simulations of the wakefield formation in a laser plasma accelerator. The method takes advantage of the properties of the Discrete Fourier Transform, the linearity of Maxwell’s equations and the finite speed of light for limiting the communications of data within guard regions between neighboring computational domains. Although this requires a small approximation, test results show that no significant error is made on the test cases that have been presented. The proposed method opens the way to solvers combining the favorable parallel scaling of standard finite-difference methods with the accuracy advantages of pseudo-spectral methods

High resolution mid-infrared spectroscopy based on frequency upconversion

DEFF Research Database (Denmark)

Dam, Jeppe Seidelin; Hu, Qi; Tidemand-Lichtenberg, Peter

2013-01-01

signals can be analyzed. The obtainable frequency resolution is usually in the nm range where sub nm resolution is preferred in many applications, like gas spectroscopy. In this work we demonstrate how to obtain sub nm resolution when using upconversion. In the presented realization one object point...... high resolution spectral performance by observing emission from hot water vapor in a butane gas burner....

Preliminary frequency-domain analysis for the reconstructed spatial resolution of muon tomography

Science.gov (United States)

Yu, B.; Zhao, Z.; Wang, X.; Wang, Y.; Wu, D.; Zeng, Z.; Zeng, M.; Yi, H.; Luo, Z.; Yue, X.; Cheng, J.

2014-11-01

Muon tomography is an advanced technology to non-destructively detect high atomic number materials. It exploits the multiple Coulomb scattering information of muon to reconstruct the scattering density image of the traversed object. Because of the statistics of muon scattering, the measurement error of system and the data incompleteness, the reconstruction is always accompanied with a certain level of interference, which will influence the reconstructed spatial resolution. While statistical noises can be reduced by extending the measuring time, system parameters determine the ultimate spatial resolution that one system can reach. In this paper, an effective frequency-domain model is proposed to analyze the reconstructed spatial resolution of muon tomography. The proposed method modifies the resolution analysis in conventional computed tomography (CT) to fit the different imaging mechanism in muon scattering tomography. The measured scattering information is described in frequency domain, then a relationship between the measurements and the original image is proposed in Fourier domain, which is named as "Muon Central Slice Theorem". Furthermore, a preliminary analytical expression of the ultimate reconstructed spatial is derived, and the simulations are performed for validation. While the method is able to predict the ultimate spatial resolution of a given system, it can also be utilized for the optimization of system design and construction.

Preliminary frequency-domain analysis for the reconstructed spatial resolution of muon tomography

International Nuclear Information System (INIS)

Yu, B.; Zhao, Z.; Wang, X.; Wang, Y.; Wu, D.; Zeng, Z.; Zeng, M.; Yi, H.; Luo, Z.; Yue, X.; Cheng, J.

2014-01-01

Muon tomography is an advanced technology to non-destructively detect high atomic number materials. It exploits the multiple Coulomb scattering information of muon to reconstruct the scattering density image of the traversed object. Because of the statistics of muon scattering, the measurement error of system and the data incompleteness, the reconstruction is always accompanied with a certain level of interference, which will influence the reconstructed spatial resolution. While statistical noises can be reduced by extending the measuring time, system parameters determine the ultimate spatial resolution that one system can reach. In this paper, an effective frequency-domain model is proposed to analyze the reconstructed spatial resolution of muon tomography. The proposed method modifies the resolution analysis in conventional computed tomography (CT) to fit the different imaging mechanism in muon scattering tomography. The measured scattering information is described in frequency domain, then a relationship between the measurements and the original image is proposed in Fourier domain, which is named as M uon Central Slice Theorem . Furthermore, a preliminary analytical expression of the ultimate reconstructed spatial is derived, and the simulations are performed for validation. While the method is able to predict the ultimate spatial resolution of a given system, it can also be utilized for the optimization of system design and construction

Validation of a clinical assessment of spectral-ripple resolution for cochlear implant users.

Science.gov (United States)

Drennan, Ward R; Anderson, Elizabeth S; Won, Jong Ho; Rubinstein, Jay T

2014-01-01

Nonspeech psychophysical tests of spectral resolution, such as the spectral-ripple discrimination task, have been shown to correlate with speech-recognition performance in cochlear implant (CI) users. However, these tests are best suited for use in the research laboratory setting and are impractical for clinical use. A test of spectral resolution that is quicker and could more easily be implemented in the clinical setting has been developed. The objectives of this study were (1) To determine whether this new clinical ripple test would yield individual results equivalent to the longer, adaptive version of the ripple-discrimination test; (2) To evaluate test-retest reliability for the clinical ripple measure; and (3) To examine the relationship between clinical ripple performance and monosyllabic word recognition in quiet for a group of CI listeners. Twenty-eight CI recipients participated in the study. Each subject was tested on both the adaptive and the clinical versions of spectral ripple discrimination, as well as consonant-nucleus-consonant word recognition in quiet. The adaptive version of spectral ripple used a two-up, one-down procedure for determining spectral ripple discrimination threshold. The clinical ripple test used a method of constant stimuli, with trials for each of 12 fixed ripple densities occurring six times in random order. Results from the clinical ripple test (proportion correct) were then compared with ripple-discrimination thresholds (in ripples per octave) from the adaptive test. The clinical ripple test showed strong concurrent validity, evidenced by a good correlation between clinical ripple and adaptive ripple results (r = 0.79), as well as a correlation with word recognition (r = 0.7). Excellent test-retest reliability was also demonstrated with a high test-retest correlation (r = 0.9). The clinical ripple test is a reliable nonlinguistic measure of spectral resolution, optimized for use with CI users in a clinical setting. The test

Airborne High Spectral Resolution Lidar Aerosol Measurements during MILAGRO and TEXAQS/GOMACCS

Science.gov (United States)

Ferrare, Richard; Hostetler, Chris; Hair, John; Cook Anthony; Harper, David; Burton, Sharon; Clayton, Marian; Clarke, Antony; Russell, Phil; Redemann, Jens

2007-01-01

Two1 field experiments conducted during 2006 provided opportunities to investigate the variability of aerosol properties near cities and the impacts of these aerosols on air quality and radiative transfer. The Megacity Initiative: Local and Global Research Observations (MILAGRO) /Megacity Aerosol Experiment in Mexico City (MAX-MEX)/Intercontinental Chemical Transport Experiment-B (INTEX-B) joint experiment conducted during March 2006 investigated the evolution and transport of pollution from Mexico City. The Texas Air Quality Study (TEXAQS)/Gulf of Mexico Atmospheric Composition and Climate Study (GoMACCS) (http://www.al.noaa.gov/2006/) conducted during August and September 2006 investigated climate and air quality in the Houston/Gulf of Mexico region. During both missions, the new NASA Langley airborne High Spectral Resolution Lidar (HSRL) was deployed on the NASA Langley B200 King Air aircraft and measured profiles of aerosol extinction, backscattering, and depolarization to: 1) characterize the spatial and vertical distributions of aerosols, 2) quantify aerosol extinction and optical thickness contributed by various aerosol types, 3) investigate aerosol variability near clouds, 4) evaluate model simulations of aerosol transport, and 5) assess aerosol optical properties derived from a combination of surface, airborne, and satellite measurements.

Effect of an 8K ultra-high-definition television system in a case of laparoscopic gynecologic surgery.

Science.gov (United States)

Aoki, Yoichi; Matsuura, Masahiko; Chiba, Toshio; Yamashita, Hiromasa

2017-09-01

Various endoscopic devices have been developed for advanced minimally invasive surgery. We recently applied a new 8K ultra-high-definition television system during laparoscopic treatment of endometriosis. The procedure, which is described in detail, stands as the first reported application of an 8K ultra-high-definition system for laparoscopic gynecologic surgery. Comparison is made between depiction of the lesion by the new system and depiction by a full high-definition system. Improved diagnostic accuracy resulted from the increased image resolution, and we believe that this and other advantages will lead to widespread acceptance and further application of 8K ultra-high-definition systems in the field of gynecologic surgery.

Retinal nerve fiber layer thickness in normals measured by spectral domain OCT.

Science.gov (United States)

Bendschneider, Delia; Tornow, Ralf P; Horn, Folkert K; Laemmer, Robert; Roessler, Christopher W; Juenemann, Anselm G; Kruse, Friedrich E; Mardin, Christian Y

2010-09-01

To determine normal values for peripapillary retinal nerve fiber layer thickness (RNFL) measured by spectral domain Optical Coherence Tomography (SOCT) in healthy white adults and to examine the relationship of RNFL with age, gender, and clinical variables. The peripapillary RNFL of 170 healthy patients (96 males and 74 females, age 20 to 78 y) was imaged with a high-resolution SOCT (Spectralis HRA+OCT, Heidelberg Engineering) in an observational cross-sectional study. RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive circular B-scans with 3.4-mm diameter. The automatically segmented RNFL thickness was divided into 32 segments (11.25 degrees each). One randomly selected eye per subject entered the study. Mean RNFL thickness in the study population was 97.2 ± 9.7 μm. Mean RNFL thickness was significantly negatively correlated with age (r = -0.214, P = 0.005), mean RNFL decrease per decade was 1.90 μm. As age dependency was different in different segments, age-correction of RNFL values was made for all segments separately. Age-adjusted RNFL thickness showed a significant correlation with axial length (r = -0.391, P = 0.001) and with refractive error (r = 0.396, P<0.001), but not with disc size (r = 0.124). Normal RNFL results with SOCT are comparable to those reported with time-domain OCT. In accordance with the literature on other devices, RNFL thickness measured with SOCT was significantly correlated with age and axial length. For creating a normative database of SOCT RNFL values have to be age adjusted.

Large scale 2D spectral compressed sensing in continuous domain

KAUST Repository

Cai, Jian-Feng

2017-06-20

We consider the problem of spectral compressed sensing in continuous domain, which aims to recover a 2-dimensional spectrally sparse signal from partially observed time samples. The signal is assumed to be a superposition of s complex sinusoids. We propose a semidefinite program for the 2D signal recovery problem. Our model is able to handle large scale 2D signals of size 500 × 500, whereas traditional approaches only handle signals of size around 20 × 20.

Large scale 2D spectral compressed sensing in continuous domain

KAUST Repository

Cai, Jian-Feng; Xu, Weiyu; Yang, Yang

2017-01-01

We consider the problem of spectral compressed sensing in continuous domain, which aims to recover a 2-dimensional spectrally sparse signal from partially observed time samples. The signal is assumed to be a superposition of s complex sinusoids. We propose a semidefinite program for the 2D signal recovery problem. Our model is able to handle large scale 2D signals of size 500 × 500, whereas traditional approaches only handle signals of size around 20 × 20.

Acoustic Event Detection in Multichannel Audio Using Gated Recurrent Neural Networks with High‐Resolution Spectral Features

Directory of Open Access Journals (Sweden)

Hyoung‐Gook Kim

2017-12-01

Full Text Available Recently, deep recurrent neural networks have achieved great success in various machine learning tasks, and have also been applied for sound event detection. The detection of temporally overlapping sound events in realistic environments is much more challenging than in monophonic detection problems. In this paper, we present an approach to improve the accuracy of polyphonic sound event detection in multichannel audio based on gated recurrent neural networks in combination with auditory spectral features. In the proposed method, human hearing perception‐based spatial and spectral‐domain noise‐reduced harmonic features are extracted from multichannel audio and used as high‐resolution spectral inputs to train gated recurrent neural networks. This provides a fast and stable convergence rate compared to long short‐term memory recurrent neural networks. Our evaluation reveals that the proposed method outperforms the conventional approaches.

Exploiting High Resolution Multi-Seasonal Textural Measures and Spectral Information for Reedbed Mapping

Directory of Open Access Journals (Sweden)

Alex Okiemute Onojeghuo

2016-02-01

Full Text Available Reedbeds across the UK are amongst the most important habitats for rare and endangered birds, wildlife and organisms. However, over the past century, this valued wetland habitat has experienced a drastic reduction in quality and spatial coverage due to pressures from human related activities. To this end, conservation organisations across the UK have been charged with the task of conserving and expanding this threatened habitat. With this backdrop, the study aimed to develop a methodology for accurate reedbed mapping through the combined use of multi-seasonal texture measures and spectral information contained in high resolution QuickBird satellite imagery. The key objectives were to determine the most effective single-date (autumn or summer and multi-seasonal QuickBird imagery suitable for reedbed mapping over the study area; to evaluate the effectiveness of combining multi-seasonal texture measures and spectral information for reedbed mapping using a variety of combinations; and to evaluate the most suitable classification technique for reedbed mapping from three selected classification techniques, namely maximum likelihood classifier, spectral angular mapper and artificial neural network. Using two selected grey-level co-occurrence textural measures (entropy and angular second moment, a series of experiments were conducted using varied combinations of single-date and multi-seasonal QuickBird imagery. Overall, the results indicate the multi-seasonal pansharpened multispectral bands (eight layers combined with all eight grey level co-occurrence matrix texture measures (entropy and angular second moment computed using windows 3 × 3 and 7 × 7 produced the optimal reedbed (76.5% and overall classification (78.1% accuracies using the maximum likelihood classifier technique. Using the optimal 16 layer multi-seasonal pansharpened multispectral and texture combined image dataset, a total reedbed area of 9.8 hectares was successfully mapped over the

Infrared emission high spectral resolution atlas of the stratospheric limb

Science.gov (United States)

Maguire, William C.; Kunde, Virgil G.; Herath, Lawrence W.

1989-01-01

An atlas of high resolution infrared emission spectra identifies a number of gaseous atmospheric features significant to stratospheric chemistry in the 770-900/cm and 1100-1360/cm regions at six zenith angles from 86.7 to 95.1 deg. A balloon-borne Michelson interferometer was flown to obtain about 0.03/cm resolution spectra. Two 10/cm extracts are presented here.

Comparison of high-resolution Scheimpflug and high-frequency ultrasound biomicroscopy to anterior-segment OCT corneal thickness measurements

Directory of Open Access Journals (Sweden)

Kanellopoulos AJ

2013-11-01

Full Text Available Anastasios John Kanellopoulos,1,2 George Asimellis1 1Laservision.gr Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USA Background: The purpose of this study was to compare and correlate central corneal thickness in healthy, nonoperated eyes with three advanced anterior-segment imaging systems: a high-resolution Scheimpflug tomography camera (Oculyzer II, a spectral-domain anterior-segment optical coherence tomography (AS-OCT system, and a high-frequency ultrasound biomicroscopy (HF-UBM system. Methods: Fifty eyes randomly selected from 50 patients were included in the study. Inclusion criteria were healthy, nonoperated eyes examined consecutively by the same examiner. Corneal imaging was performed by three different methods, ie, Oculyzer II, spectral-domain AS-OCT, and FH-UBM. Central corneal thickness measurements were compared using scatter diagrams, Bland-Altman plots (with bias and 95% confidence intervals, and two-paired analysis. Results: The coefficient of determination (r2 between the Oculyzer II and AS-OCT measurements was 0.895. Likewise, the coefficient was 0.893 between the Oculyzer II and HF-UBM and 0.830 between the AS-OCT and HF-UBM. The trend line coefficients of linearity were 0.925 between the Oculyzer II and the AS-OCT, 1.006 between the Oculyzer II and HF-UBM, and 0.841 between the AS-OCT and HF-UBM. The differences in average corneal thickness between the three pairs of CCT measurements were –6.86 µm between the Oculyzer II and HF-UBM, –12.20 µm between the AS-OCT and Oculyzer II, and +19.06 µm between the HF-UBM and AS-OCT. Conclusion: The three methods used for corneal thickness measurement are highly correlated. Compared with the Scheimplug and ultrasound devices, the AS-OCT appears to report a more accurate, but overally thinner corneal pachymetry. Keywords: anterior eye segment, high-frequency ultrasound biomicroscopy, optical coherence tomography, high-resolution Pentacam

Reproducible high-resolution multispectral image acquisition in dermatology

Science.gov (United States)

Duliu, Alexandru; Gardiazabal, José; Lasser, Tobias; Navab, Nassir

2015-07-01

Multispectral image acquisitions are increasingly popular in dermatology, due to their improved spectral resolution which enables better tissue discrimination. Most applications however focus on restricted regions of interest, imaging only small lesions. In this work we present and discuss an imaging framework for high-resolution multispectral imaging on large regions of interest.

High-resolution functional MRI of the human amygdala at 7 T

Energy Technology Data Exchange (ETDEWEB)

Sladky, Ronald, E-mail: ronald.sladky@meduniwien.ac.at [MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna (Austria); Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna (Austria); Baldinger, Pia; Kranz, Georg S. [Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna (Austria); Tröstl, Jasmin [MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna (Austria); Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna (Austria); Höflich, Anna; Lanzenberger, Rupert [Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna (Austria); Moser, Ewald [MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna (Austria); Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna (Austria); Windischberger, Christian, E-mail: christian.windischberger@meduniwien.ac.at [MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna (Austria); Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna (Austria)

2013-05-15

Functional magnetic resonance imaging (fMRI) has become the primary non-invasive method for investigating the human brain function. With an increasing number of ultra-high field MR systems worldwide possibilities of higher spatial and temporal resolution in combination with increased sensitivity and specificity are expected to advance detailed imaging of distinct cortical brain areas and subcortical structures. One target region of particular importance to applications in psychiatry and psychology is the amygdala. However, ultra-high field magnetic resonance imaging of these ventral brain regions is a challenging endeavor that requires particular methodological considerations. Ventral brain areas are particularly prone to signal losses arising from strong magnetic field inhomogeneities along susceptibility borders. In addition, physiological artifacts from respiration and cardiac action cause considerable fluctuations in the MR signal. Here we show that, despite these challenges, fMRI data from the amygdala may be obtained with high temporal and spatial resolution combined with increased signal-to-noise ratio. Maps of neural activation during a facial emotion discrimination paradigm at 7 T are presented and clearly show the gain in percental signal change compared to 3 T results, demonstrating the potential benefits of ultra-high field functional MR imaging also in ventral brain areas.

High-resolution functional MRI of the human amygdala at 7 T

International Nuclear Information System (INIS)

Sladky, Ronald; Baldinger, Pia; Kranz, Georg S.; Tröstl, Jasmin; Höflich, Anna; Lanzenberger, Rupert; Moser, Ewald; Windischberger, Christian

2013-01-01

Functional magnetic resonance imaging (fMRI) has become the primary non-invasive method for investigating the human brain function. With an increasing number of ultra-high field MR systems worldwide possibilities of higher spatial and temporal resolution in combination with increased sensitivity and specificity are expected to advance detailed imaging of distinct cortical brain areas and subcortical structures. One target region of particular importance to applications in psychiatry and psychology is the amygdala. However, ultra-high field magnetic resonance imaging of these ventral brain regions is a challenging endeavor that requires particular methodological considerations. Ventral brain areas are particularly prone to signal losses arising from strong magnetic field inhomogeneities along susceptibility borders. In addition, physiological artifacts from respiration and cardiac action cause considerable fluctuations in the MR signal. Here we show that, despite these challenges, fMRI data from the amygdala may be obtained with high temporal and spatial resolution combined with increased signal-to-noise ratio. Maps of neural activation during a facial emotion discrimination paradigm at 7 T are presented and clearly show the gain in percental signal change compared to 3 T results, demonstrating the potential benefits of ultra-high field functional MR imaging also in ventral brain areas

Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing

Directory of Open Access Journals (Sweden)

Lank Simon M

2012-08-01

Full Text Available Abstract Background High-resolution HLA genotyping is a critical diagnostic and research assay. Current methods rarely achieve unambiguous high-resolution typing without making population-specific frequency inferences due to a lack of locus coverage and difficulty in exon-phase matching. Achieving high-resolution typing is also becoming more challenging with traditional methods as the database of known HLA alleles increases. Results We designed a cDNA amplicon-based pyrosequencing method to capture 94% of the HLA class I open-reading-frame with only two amplicons per sample, and an analogous method for class II HLA genes, with a primary focus on sequencing the DRB loci. We present a novel Galaxy server-based analysis workflow for determining genotype. During assay validation, we performed two GS Junior sequencing runs to determine the accuracy of the HLA class I amplicons and DRB amplicon at different levels of multiplexing. When 116 amplicons were multiplexed, we unambiguously resolved 99%of class I alleles to four- or six-digit resolution, as well as 100% unambiguous DRB calls. The second experiment, with 271 multiplexed amplicons, missed some alleles, but generated high-resolution, concordant typing for 93% of class I alleles, and 96% for DRB1 alleles. In a third, preliminary experiment we attempted to sequence novel amplicons for other class II loci with mixed success. Conclusions The presented assay is higher-throughput and higher-resolution than existing HLA genotyping methods, and suitable for allele discovery or large cohort sampling. The validated class I and DRB primers successfully generated unambiguously high-resolution genotypes, while further work is needed to validate additional class II genotyping amplicons.

Spectral resolution control of acousto-optical cells operating with collimated and divergent beams

Science.gov (United States)

Voloshinov, Vitaly B.; Mishin, Dimitry D.

1994-01-01

The paper is devoted to theoretical and experimental investigations of acousto-optical interactions in crystals which may be used for spectral filtration of light in tunable acousto- optical filters. Attention is paid to spectral resolution control during operation with divergent or collimated noncoherent optical beams. In all examined cases spectral bands of anisotropic Bragg diffraction were regulated by means of novel electronical methods. Resolution control was achieved in paratellurite cells with non-collinear and quasi-collinear regimes of the diffraction. Filtration spectral bandwidths for visible light were electronically changed by a factor of 10 divided by 20 by drive electrical signals switching and drive electrical power regulations.

Post-mortem inference of the human hippocampal connectivity and microstructure using ultra-high field diffusion MRI at 11.7 T.

Science.gov (United States)

Beaujoin, Justine; Palomero-Gallagher, Nicola; Boumezbeur, Fawzi; Axer, Markus; Bernard, Jeremy; Poupon, Fabrice; Schmitz, Daniel; Mangin, Jean-François; Poupon, Cyril

2018-06-01

The human hippocampus plays a key role in memory management and is one of the first structures affected by Alzheimer's disease. Ultra-high magnetic resonance imaging provides access to its inner structure in vivo. However, gradient limitations on clinical systems hinder access to its inner connectivity and microstructure. A major target of this paper is the demonstration of diffusion MRI potential, using ultra-high field (11.7 T) and strong gradients (750 mT/m), to reveal the extra- and intra-hippocampal connectivity in addition to its microstructure. To this purpose, a multiple-shell diffusion-weighted acquisition protocol was developed to reach an ultra-high spatio-angular resolution with a good signal-to-noise ratio. The MRI data set was analyzed using analytical Q-Ball Imaging, Diffusion Tensor Imaging (DTI), and Neurite Orientation Dispersion and Density Imaging models. High Angular Resolution Diffusion Imaging estimates allowed us to obtain an accurate tractography resolving more complex fiber architecture than DTI models, and subsequently provided a map of the cross-regional connectivity. The neurite density was akin to that found in the histological literature, revealing the three hippocampal layers. Moreover, a gradient of connectivity and neurite density was observed between the anterior and the posterior part of the hippocampus. These results demonstrate that ex vivo ultra-high field/ultra-high gradients diffusion-weighted MRI allows the mapping of the inner connectivity of the human hippocampus, its microstructure, and to accurately reconstruct elements of the polysynaptic intra-hippocampal pathway using fiber tractography techniques at very high spatial/angular resolutions.

High spectral resolution image of Barnacle Bill

Science.gov (United States)

1997-01-01

The rover Sojourner's first target for measurement by the Alpha-Proton-Xray Spectrometer (APXS) was the rock named Barnacle Bill, located close to the ramp down which the rover made its egress from the lander. The full spectral capability of the Imager for Mars Pathfinder (IMP), consisting of 13 wavelength filters, was used to characterize the rock's surface. The measured area is relatively dark, and is shown in blue. Nearby on the rock surface, soil material is trapped in pits (shown in red).Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator. JPL is an operating division of the California Institute of Technology (Caltech).

Detergent/nanodisc screening for high-resolution NMR studies of an integral membrane protein containing a cytoplasmic domain.

Directory of Open Access Journals (Sweden)

Christos Tzitzilonis

Full Text Available Because membrane proteins need to be extracted from their natural environment and reconstituted in artificial milieus for the 3D structure determination by X-ray crystallography or NMR, the search for membrane mimetic that conserve the native structure and functional activities remains challenging. We demonstrate here a detergent/nanodisc screening study by NMR of the bacterial α-helical membrane protein YgaP containing a cytoplasmic rhodanese domain. The analysis of 2D [(15N,(1H]-TROSY spectra shows that only a careful usage of low amounts of mixed detergents did not perturb the cytoplasmic domain while solubilizing in parallel the transmembrane segments with good spectral quality. In contrast, the incorporation of YgaP into nanodiscs appeared to be straightforward and yielded a surprisingly high quality [(15N,(1H]-TROSY spectrum opening an avenue for the structural studies of a helical membrane protein in a bilayer system by solution state NMR.

High-resolution measurements and multichannel quantum defect analysis of spectral line shapes of autoionizing Rydberg series

International Nuclear Information System (INIS)

Ueda, Kiyoshi

1997-01-01

Spectral line shapes for autoionizing Rydberg series are briefly reviewed within the framework of multichannel quantum defect theory (MQDT). Recent high-resolution measurements and MQDT analysis for the spectra line shapes are reviewed for the mp 5 ( 2 P 1/2 )ns ' and nd ' J=1 odd spectra of the Ar, Kr, and Xe atoms (m=3,4,5 for Ar, Kr, and Xe) and the 3p 5 ( 2 P 1/2 )nd ' J=2 and 3 odd spectra of Ar*3p 5 4p excited atoms. Some results are also discussed for the Ca 4p( 2 P 1/2,3/2 )ns and nd J=1 odd spectrum and the Ba 5d( 2 P 5/2 )nd J=1 odd spectrum

Secondary electron spectroscopy and Auger microscopy at high spatial resolution. Application to scanning electron microscopy

International Nuclear Information System (INIS)

Le Gressus, Claude; Massignon, Daniel; Sopizet, Rene

1979-01-01

Secondary electron spectroscopy (SES), Auger electron spectroscopy (AES) and electron energy loss spectroscopy (ELS) are combined with ultra high vacuum scanning microscopy (SEM) for surface analysis at high spatial resolution. Reliability tests for the optical column for the vacuum and for the spectrometer are discussed. Furthermore the sensitivity threshold in AES which is compatible with a non destructive surface analysis at high spatial resolution is evaluated. This combination of all spectroscopies is used in the study of the beam damage correlated with the well known secondary electron image (SEI) darkening still observed in ultra high vacuum. The darkening is explained as a bulk decontamination of the sample rather than as a surface contamination from the residual vacuum gas [fr

256-pixel microcalorimeter array for high-resolution γ-ray spectroscopy of mixed-actinide materials

Energy Technology Data Exchange (ETDEWEB)

Winkler, R., E-mail: rwinkler@lanl.gov [Los Alamos National Laboratory, Los Alamos, NM (United States); Hoover, A.S.; Rabin, M.W. [Los Alamos National Laboratory, Los Alamos, NM (United States); Bennett, D.A.; Doriese, W.B.; Fowler, J.W.; Hays-Wehle, J.; Horansky, R.D.; Reintsema, C.D.; Schmidt, D.R.; Vale, L.R.; Ullom, J.N. [National Institute of Standards and Technology, Boulder, CO (United States)

2015-01-11

The application of cryogenic microcalorimeter detectors to γ-ray spectroscopy allows for measurements with unprecedented energy resolution. These detectors are ideally suited for γ-ray spectroscopy applications for which the measurement quality is limited by the spectral overlap of many closely spaced transitions using conventional detector technologies. The non-destructive analysis of mixed-isotope Pu materials is one such application where the precision can be potentially improved utilizing microcalorimeter detectors compared to current state-of-the-art high-purity Ge detectors (HPGe). The LANL-NIST γ-ray spectrometer, a 256-pixel microcalorimeter array based on transition-edge sensors (TESs), was recently commissioned and used to collect data on a variety of Pu isotopic standards to characterize the instrument performance. These measurements represent the first time the simultaneous readout of all 256 pixels for measurements of mixed-isotope Pu materials has been achieved. The LANL-NIST γ-ray spectrometer has demonstrated an average pixel resolution of 55 eV full-width-at-half-maximum at 100 keV, nearly an order of magnitude better than HPGe detectors. Some challenges of the analysis of many-channel ultra-high resolution data and the techniques used to produce quality spectra for isotopic analysis will be presented. The LANL-NIST γ-ray spectrometer has also demonstrated stable operation and obtained high resolution measurements at total array event rates beyond 1 kHz. For a total event rate of 1.25 kHz, approximately 5.6 cps/pixel, a 72.2 eV average FWHM for the 103 keV photopeak of {sup 153}Gd was achieved.

Enhanced spectral resolution by high-dimensional NMR using the filter diagonalization method and "hidden" dimensions.

Science.gov (United States)

Meng, Xi; Nguyen, Bao D; Ridge, Clark; Shaka, A J

2009-01-01

High-dimensional (HD) NMR spectra have poorer digital resolution than low-dimensional (LD) spectra, for a fixed amount of experiment time. This has led to "reduced-dimensionality" strategies, in which several LD projections of the HD NMR spectrum are acquired, each with higher digital resolution; an approximate HD spectrum is then inferred by some means. We propose a strategy that moves in the opposite direction, by adding more time dimensions to increase the information content of the data set, even if only a very sparse time grid is used in each dimension. The full HD time-domain data can be analyzed by the filter diagonalization method (FDM), yielding very narrow resonances along all of the frequency axes, even those with sparse sampling. Integrating over the added dimensions of HD FDM NMR spectra reconstitutes LD spectra with enhanced resolution, often more quickly than direct acquisition of the LD spectrum with a larger number of grid points in each of the fewer dimensions. If the extra-dimensions do not appear in the final spectrum, and are used solely to boost information content, we propose the moniker hidden-dimension NMR. This work shows that HD peaks have unmistakable frequency signatures that can be detected as single HD objects by an appropriate algorithm, even though their patterns would be tricky for a human operator to visualize or recognize, and even if digital resolution in an HD FT spectrum is very coarse compared with natural line widths.

Comparison of Two Grid Refinement Approaches for High Resolution Regional Climate Modeling: MPAS vs WRF

Science.gov (United States)

Leung, L.; Hagos, S. M.; Rauscher, S.; Ringler, T.

2012-12-01

This study compares two grid refinement approaches using global variable resolution model and nesting for high-resolution regional climate modeling. The global variable resolution model, Model for Prediction Across Scales (MPAS), and the limited area model, Weather Research and Forecasting (WRF) model, are compared in an idealized aqua-planet context with a focus on the spatial and temporal characteristics of tropical precipitation simulated by the models using the same physics package from the Community Atmosphere Model (CAM4). For MPAS, simulations have been performed with a quasi-uniform resolution global domain at coarse (1 degree) and high (0.25 degree) resolution, and a variable resolution domain with a high-resolution region at 0.25 degree configured inside a coarse resolution global domain at 1 degree resolution. Similarly, WRF has been configured to run on a coarse (1 degree) and high (0.25 degree) resolution tropical channel domain as well as a nested domain with a high-resolution region at 0.25 degree nested two-way inside the coarse resolution (1 degree) tropical channel. The variable resolution or nested simulations are compared against the high-resolution simulations that serve as virtual reality. Both MPAS and WRF simulate 20-day Kelvin waves propagating through the high-resolution domains fairly unaffected by the change in resolution. In addition, both models respond to increased resolution with enhanced precipitation. Grid refinement induces zonal asymmetry in precipitation (heating), accompanied by zonal anomalous Walker like circulations and standing Rossby wave signals. However, there are important differences between the anomalous patterns in MPAS and WRF due to differences in the grid refinement approaches and sensitivity of model physics to grid resolution. This study highlights the need for "scale aware" parameterizations in variable resolution and nested regional models.

OTR profile measurement of a LINAC electron beam with portable ultra high-speed camera

International Nuclear Information System (INIS)

Mogi, T.; Nisiyama, S.; Tomioka, S.; Enoto, T.

2004-01-01

We have studied on and developed a portable ultra high-speed camera, and so applied to measurement of a LINAC electron beam. We measured spatial OTR profiles of a LINAC electron beam using this camera with temporal resolution 80ns. (author)

Solution to the spectral filter problem of residual terrain modelling (RTM)

Science.gov (United States)

Rexer, Moritz; Hirt, Christian; Bucha, Blažej; Holmes, Simon

2018-06-01

valley fillings) were found to stand out more clearly in the RTM-reduced gravity measurements when the HF and LF correction are taken into account. In summary, the new RTM filter corrections can be easily computed and applied to improve the spectral filter characteristics of the popular RTM approach. Benefits are expected, e.g. in the context of the development of future ultra-high-resolution global gravity models, smoothing of observed gravity data in mountainous terrain and geophysical interpretations of RTM-reduced gravity measurements.

SOLARNET: a high resolution mission to complement the ILWS programme

Science.gov (United States)

Dame, L.; Clade, S.; Malherbe, J. M.

SOLARNET is a medium size high resolution solar physics mission proposed to CNES for a new start in 2006 and a possible launch in 2010. Partnerships with Germany, Belgium, China and India are under discussion. At the center of the SOLARNET mission is a 3-telescopes interferometer of 1 meter baseline capable to provide 50 times the best ever spatial resolution achieved in Space with previous, current or even planned solar missions: 20 mas - 20 km on the Sun in the FUV. The interferometer is associated to an on-axis subtractive double monochromator (imaging spectrograph) capable of high spectral (0.01 nm) and high temporal resolutions (50 ms) on a field of view of 40 arcsec and over the FUV and UV spectral domains (from 117.5 to 400 nm). This will allow to access process scales of magnetic reconnection, dissipation, emerging flux and much more, from the high chromosphere to the low corona with emphasis on the transition zone where the magnetic confinement is expected to be maximum. A whole new chapter of the physics of solar magnetic field structuring and evolution will be opened. The interferometer is complemented by several other instruments providing larger field of view and higher temperature (EUV-XUV coronal imaging) to define the context and extension of the solar phenomena. Helioseismology, a strong asset of SOHO, is also intended with both velocity and diameter measures, allowed by a non-eclipsing Sun synchronous orbit. The SOLARNET interferometer design results of an extensive laboratory demonstration program of interferometric imaging of extended objects. It started 10 years ago and culminates this year with the first interferometric observations (images) of the Sun at Meudon Observatory at the "Grand Siderostat de Foucault" with a complete 3 telescopes cophased interferometer representative of SOLARNET. We will review the scientific program of SOLARNET, describe the interferometer concept and design, present the first solar imaging results of the

Functional magnetic resonance imaging with ultra-high fields

International Nuclear Information System (INIS)

Windischberger, C.; Schoepf, V.; Sladky, R.; Moser, E.; Fischmeister, F.P.S.

2010-01-01

Functional magnetic resonance imaging (fMRI) is currently the primary method for non-invasive functional localization in the brain. With the emergence of MR systems with field strengths of 4 Tesla and above, neuronal activation may be studied with unprecedented accuracy. In this article we present different approaches to use the improved sensitivity and specificity for expanding current fMRT resolution limits in space and time based on several 7 Tesla studies. In addition to the challenges that arise with ultra-high magnetic fields possible solutions will be discussed. (orig.) [de

Mapping of landfills using time-domain spectral induced polarization data

DEFF Research Database (Denmark)

Gazoty, Aurélie; Fiandaca, Gianluca; Pedersen, Jesper Bjergsted

2012-01-01

This study uses time-domain induced polarization data for the delineation and characterization of the former landfill site at Eskelund, Denmark. With optimized acquisition parameters combined with a new inversion algorithm, we use the full content of the decay curve and retrieve spectral informat......This study uses time-domain induced polarization data for the delineation and characterization of the former landfill site at Eskelund, Denmark. With optimized acquisition parameters combined with a new inversion algorithm, we use the full content of the decay curve and retrieve spectral...... information from time-domain IP data. Thirteen IP/DC profiles were collected in the area, supplemented by el-log drilling for accurate correlation between the geophysics and the lithology. The data were inverted using a laterally constrained 1D inversion considering the full decay curves to retrieve the four......-log measurements giving in situ values, for which the Cole-Cole parameters were computed. The 3D shape of the waste body was pinpointed and well-defined. The inversion of the IP data also shows a strong correlation with the initial stage of the waste dump and its composition combining an aerial map with acquired...

In-Situ Assay Of Transuranic Radionuclides In The Vadose Zone Using High-Resolution Spectral Gamma Logging - A Hanford Case Study

International Nuclear Information System (INIS)

Rohay, V.J.; Henwood, P.; McCain, R.

2009-01-01

High-resolution spectral gamma logging in steel-cased boreholes is used to detect and quantify transuranic radionuclides in the subsurface. Pu-239, Pu-241, Am-241, and Np-237 are identified based on characteristic decay gammas. Typical minimum detectable levels are on the order of 20 to 40 nCi/g. In intervals of high transuranic concentrations, gamma rays from other sources may complicate analysis and interpretation. Gamma rays detected in the borehole may originate from three sources: decay of the parent transuranic radionuclide or a daughter; alpha interactions; and interactions with neutrons resulting from either spontaneous fission or alpha particle interactions.

High Spectral Resolution LIDAR as a Tool for Air Quality Research

Science.gov (United States)

Eloranta, E. W.; Spuler, S.; Hayman, M. M.

2017-12-01

Many aspects of air quality research require information on the vertical distribution of pollution. Traditional measurements, obtained from surface based samplers, or passive satellite remote sensing, do not provide vertical profiles. Lidar can provide profiles of aerosol properties. However traditional backscatter lidar suffers from uncertain calibrations with poorly constrained algorithms. These problems are avoided using High Spectral Resolution Lidar (HSRL) which provides absolutely calibrated vertical profiles of aerosol properties. The University of Wisconsin HSRL systems measure 532 nm wavelength aerosol backscatter cross-sections, extinction cross-sections, depolarization, and attenuated 1064 nm backscatter. These instruments are designed for long-term deployment at remote sites with minimal local support. Processed data is provided for public viewing and download in real-time on our web site "http://hsrl.ssec.wisc.edu". Air pollution applications of HSRL data will be illustrated with examples acquired during air quality field programs including; KORUS-AQ, DISCOVER-AQ, LAMOS and FRAPPE. Observations include 1) long range transport of dust, air pollution and smoke. 2) Fumigation episodes where elevated pollution is mixed down to the surface. 3) visibility restrictions by aerosols and 4) diurnal variations in atmospheric optical depth. While HSRL is powerful air quality research tool, its application in routine measurement networks is hindered by the high cost of current systems. Recent technical advances promise a next generation HSRL using telcom components to greatly reduce system cost. This paper will present data generated by a prototype low cost system constructed at NCAR. In addition to lower cost, operation at a non-visible near 780 nm infrared wavelength removes all FAA restrictions on the operation.

The dynamic range of ultra-high-resolution cryogenic gamma-ray spectrometers

Energy Technology Data Exchange (ETDEWEB)

Ali, Shafinaz [Advanced Detector Group, Lawrence Livermore National Laboratory, 7000 East Avenue, L-270, Livermore, CA 94550 (United States); Terracol, Stephane F. [Advanced Detector Group, Lawrence Livermore National Laboratory, 7000 East Avenue, L-270, Livermore, CA 94550 (United States); Drury, Owen B. [Advanced Detector Group, Lawrence Livermore National Laboratory, 7000 East Avenue, L-270, Livermore, CA 94550 (United States); Friedrich, Stephan [Advanced Detector Group, Lawrence Livermore National Laboratory, 7000 East Avenue, L-270, Livermore, CA 94550 (United States)]. E-mail: friedrich1@llnl.gov

2006-04-15

We are developing high-resolution cryogenic gamma-ray spectrometers for nuclear science and non-proliferation applications. The gamma-ray detectors are composed of a bulk superconducting Sn foil absorber attached to a multilayer Mo/Cu transition-edge sensor (TES). The energy resolution of a detector with a 1x1x0.25 mm{sup 3} Sn absorber is 50-90 eV FWHM for {gamma}-rays up to 100 keV, and it decreases for larger absorbers. Here, we present the detector performance for different absorber volumes, and discuss the trade-offs between energy resolution and dynamic range.

The Dynamic Range of Ultra-High Resolution Cryogenic Gamma-ray Spectrometers

International Nuclear Information System (INIS)

Ali, S; Terracol, S F; Drury, O B; Friedrich, S

2005-01-01

We are developing high-resolution cryogenic gamma-ray spectrometers for nuclear science and non-proliferation applications. The gamma-ray detectors are composed of a bulk superconducting Sn foil absorber attached to multilayer Mo/Cu transition-edge sensors (TES). The energy resolution achieved with a 1 x 1 x 0.25 mm 3 Sn absorber is 50 -90eV for γ-rays up to 100 keV and it decreases for large absorber sizes. We discuss the trade-offs between energy resolution and dynamic range, as well as development of TES arrays for higher count rates and better sensitivity

The Heart of China revisited: II Early Paleozoic (ultra)high-pressure and (ultra)high-temperature metamorphic Qinling orogenic collage

Science.gov (United States)

Bader, Thomas; Franz, Leander; Ratschbacher, Lothar; de Capitani, Christian; Webb, A. Alexander G.; Yang, Zhao; Pfänder, Jörg A.; Hofmann, Mandy; Linnemann, Ulf

2013-07-01

Orogens with multiple (ultra)high-pressure ((U)HP) and (ultra)high-temperature ((U)HT) metamorphic events provide a complex but telling record of oceanic and continental interaction. The Early Paleozoic history of the "Heart of China," the Qinling orogenic collage, offers snapshots of at least three (U)HP and two (U)HT metamorphic events. The preservation of remnants of both oceanic and continental domains together with a ≥110 Myr record of magmatism allows the reconstruction of the processes that resulted in this disparate metamorphism. Herein, we first illuminate the pressure-temperature-time (P-T-t) evolution of the Early Paleozoic (U)HP and (U)HT events by refining the petrographic descriptions and P-T estimates, assess published, and employ new U/Th-Pb zircon, monazite, and titanite, and 40Ar-39Ar phengite geochronology to date the magmatic and metamorphic events. Then we explore how the metamorphic and magmatic events are related tectonically and how they elucidate the affinities among the various complexes in the Qinling orogenic collage. We argue that a Meso-Neoproterozoic crustal fragment—the Qinling complex—localized subduction-accretion events that involved subduction, oceanic-arc formation, and back-arc spreading along its northern margin, and mtantle-wedge exhumation and spreading-ridge subduction along its southern margin.

Ultra-high-resolution C-arm flat-detector CT angiography evaluation reveals 3-fold higher association rate for sporadic intracranial cavernous malformations and developmental venous anomalies: a retrospective study in consecutive 58 patients with 60 cavernous malformations

Energy Technology Data Exchange (ETDEWEB)

Kocak, Burak [Aksaray State Hospital, Department of Radiology, Aksaray (Turkey); Kizilkilic, Osman; Kocer, Naci; Islak, Civan [Istanbul University, Department of Radiology, Cerrahpasa Medical Faculty, Istanbul (Turkey); Oz, Buge; Bakkaloglu, Dogu Vuralli [Istanbul University, Department of Pathology, Cerrahpasa Medical Faculty, Istanbul (Turkey); Isler, Cihan [Istanbul University, Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul (Turkey)

2017-06-15

The imaging and surgical literature has confusing association rates for the association between sporadic intracranial cavernous malformations (CMs) and developmental venous anomalies (DVAs). In this study, our purpose was to determine the association rate using ultra-high-resolution C-arm flat-detector CT angiography (FDCTA) and compare it with literature. Fifty-eight patients with 60 sporadic intracranial CMs that underwent an FDCTA study were included in our retrospective study. Re-evaluation of radiological data was performed based on the criteria defined by authors. Isotropic volumetric reconstructions with ultra-high resolution (voxel size of 102 μm{sup 3} for initial; 67 μm{sup 3} and 32 μm{sup 3} for further evaluation) were used for assessment. Sixteen patients underwent surgery for excision of their CMs. Fifty-one of all patients (87.9 %) were associated with a DVA. Undefined local venous structures (UD-LVSs) were observed in the remaining 7 patients (12.1 %). The strength of interobserver agreement was excellent [kappa(k) coefficient = 0.923]. Ultra-high-resolution FDCTA evaluation of CMs and DVAs reveals 3-fold higher association rate compared to the literature. FDCTA for patients with sporadic CMs could help identify the associated DVAs that remained undetected or unclear with other imaging modalities, which can be useful in decision-making processes, planning surgery, and during operation. (orig.)

VALIDATION OF A CLINICAL ASSESSMENT OF SPECTRAL RIPPLE RESOLUTION FOR COCHLEAR-IMPLANT USERS

Science.gov (United States)

Drennan, Ward. R.; Anderson, Elizabeth S.; Won, Jong Ho; Rubinstein, Jay T.

2013-01-01

Objectives Non-speech psychophysical tests of spectral resolution, such as the spectral-ripple discrimination task, have been shown to correlate with speech recognition performance in cochlear implant (CI) users (Henry et al., 2005; Won et al. 2007, 2011; Drennan et al. 2008; Anderson et al. 2011). However, these tests are best suited for use in the research laboratory setting and are impractical for clinical use. A test of spectral resolution that is quicker and could more easily be implemented in the clinical setting has been developed. The objectives of this study were 1) To determine if this new clinical ripple test would yield individual results equivalent to the longer, adaptive version of the ripple discrimination test; 2) To evaluate test-retest reliability for the clinical ripple measure; and 3) To examine the relationship between clinical ripple performance and monosyllabic word recognition in quiet for a group of CI listeners. Design Twenty-eight CI recipients participated in the study. Each subject was tested on both the adaptive and the clinical versions of spectral ripple discrimination, as well as CNC word recognition in quiet. The adaptive version of spectral ripple employed a 2-up, 1-down procedure for determining spectral ripple discrimination threshold. The clinical ripple test used a method of constant stimuli, with trials for each of 12 fixed ripple densities occurring six times in random order. Results from the clinical ripple test (proportion correct) were then compared to ripple discrimination thresholds (in ripples per octave) from the adaptive test. Results The clinical ripple test showed strong concurrent validity, evidenced by a good correlation between clinical ripple and adaptive ripple results (r=0.79), as well as a correlation with word recognition (r = 0.7). Excellent test-retest reliability was also demonstrated with a high test-retest correlation (r = 0.9). Conclusions The clinical ripple test is a reliable non-linguistic measure

High-resolution monochromated electron energy-loss spectroscopy of organic photovoltaic materials.

Science.gov (United States)

Alexander, Jessica A; Scheltens, Frank J; Drummy, Lawrence F; Durstock, Michael F; Hage, Fredrik S; Ramasse, Quentin M; McComb, David W

2017-09-01

Advances in electron monochromator technology are providing opportunities for high energy resolution (10 - 200meV) electron energy-loss spectroscopy (EELS) to be performed in the scanning transmission electron microscope (STEM). The energy-loss near-edge structure in core-loss spectroscopy is often limited by core-hole lifetimes rather than the energy spread of the incident illumination. However, in the valence-loss region, the reduced width of the zero loss peak makes it possible to resolve clearly and unambiguously spectral features at very low energy-losses (photovoltaics (OPVs): poly(3-hexlythiophene) (P3HT), [6,6] phenyl-C 61 butyric acid methyl ester (PCBM), copper phthalocyanine (CuPc), and fullerene (C 60 ). Data was collected on two different monochromated instruments - a Nion UltraSTEM 100 MC 'HERMES' and a FEI Titan 3 60-300 Image-Corrected S/TEM - using energy resolutions (as defined by the zero loss peak full-width at half-maximum) of 35meV and 175meV, respectively. The data was acquired to allow deconvolution of plural scattering, and Kramers-Kronig analysis was utilized to extract the complex dielectric functions. The real and imaginary parts of the complex dielectric functions obtained from the two instruments were compared to evaluate if the enhanced resolution in the Nion provides new opto-electronic information for these organic materials. The differences between the spectra are discussed, and the implications for STEM-EELS studies of advanced materials are considered. Copyright © 2017 Elsevier B.V. All rights reserved.

Comparison of ultra-high performance supercritical fluid chromatography and ultra-high performance liquid chromatography for the separation of spirostanol saponins.

Science.gov (United States)

Zhu, Ling-Ling; Zhao, Yang; Xu, Yong-Wei; Sun, Qing-Long; Sun, Xin-Guang; Kang, Li-Ping; Yan, Ren-Yi; Zhang, Jie; Liu, Chao; Ma, Bai-Ping

2016-02-20

Spirostanol saponins are important active components of some herb medicines, and their isolation and purification are crucial for the research and development of traditional Chinese medicines. We aimed to compare the separation of spirostanol saponins by ultra-high performance supercritical fluid chromatography (UHPSFC) and ultra-high performance liquid chromatography (UHPLC). Four groups of spirostanol saponins were separated respectively by UHPSFC and UHPLC. After optimization, UHPSFC was performed with a HSS C18 SB column or a Diol column and with methanol as the co-solvent. A BEH C18 column and mobile phase containing water (with 0.1% formic acid) and acetonitrile were used in UHPLC. We found that UHPSFC could be performed automatically and quickly. It is effective in separating the spirostanol saponins which share the same aglycone and vary in sugar chains, and is very sensitive to the number and the position of hydroxyl groups in aglycones. However, the resolution of spirostanol saponins with different aglycones and the same sugar moiety by UHPSFC was not ideal and could be resolved by UHPLC instead. UHPLC is good at differentiating the variation in aglycones, and is influenced by double bonds in aglycones. Therefore, UHPLC and UHPSFC are complementary in separating spirostanol saponins. Considering the naturally produced spirostanol saponins in herb medicines are different both in aglycones and in sugar chains, a better separation can be achieved by combination of UHPLC and UHPSFC. UHPSFC is a powerful technique for improving the resolution when UHPLC cannot resolve a mixture of spirostanol saponins and vice versa. Copyright © 2015 Elsevier B.V. All rights reserved.

Impact of spectral nudging and domain size in studies of RCM response to parameter modification

Energy Technology Data Exchange (ETDEWEB)

Separovic, Leo; Laprise, Rene [Universite du Quebec a Montreal, Centre pour l' Etude et la Simulation du Climat a l' Echelle Regionale (ESCER), Montreal, QC (Canada); Universite du Quebec a Montreal (UQAM), Montreal, QC (Canada); Elia, Ramon de [Universite du Quebec a Montreal, Centre pour l' Etude et la Simulation du Climat a l' Echelle Regionale (ESCER), Montreal, QC (Canada); Consortium Ouranos, Montreal, QC (Canada)

2012-04-15

The paper aims at finding an RCM configuration that facilitates studies devoted to quantifying RCM response to parameter modification. When using short integration times, the response of the time-averaged variables to RCM modification tend to be blurred by the noise originating in the lack of predictability of the instantaneous atmospheric states. Two ways of enhancing the signal-to-noise ratio are studied in this work: spectral nudging and reduction of the computational domain size. The approach followed consists in the analysis of the sensitivity of RCM-simulated seasonal averages to perturbations of two parameters controlling deep convection and stratiform condensation, perturbed one at a time. Sensitivity is analyzed within different simulation configurations obtained by varying domain size and using the spectral nudging option. For each combination of these factors multiple members of identical simulations that differ exclusively in initial conditions are also generated to provide robust estimates of the sensitivities (the signal) and sample the noise. Results show that the noise magnitude is decreased both by reduction of domain size and the spectral nudging. However, the reduction of domain size alters some sensitivity signals. When spectral nudging is used significant alterations of the signal are not found. (orig.)

Optimisation of chromatographic resolution using objective functions including both time and spectral information.

Science.gov (United States)

Torres-Lapasió, J R; Pous-Torres, S; Ortiz-Bolsico, C; García-Alvarez-Coque, M C

2015-01-16

The optimisation of the resolution in high-performance liquid chromatography is traditionally performed attending only to the time information. However, even in the optimal conditions, some peak pairs may remain unresolved. Such incomplete resolution can be still accomplished by deconvolution, which can be carried out with more guarantees of success by including spectral information. In this work, two-way chromatographic objective functions (COFs) that incorporate both time and spectral information were tested, based on the peak purity (analyte peak fraction free of overlapping) and the multivariate selectivity (figure of merit derived from the net analyte signal) concepts. These COFs are sensitive to situations where the components that coelute in a mixture show some spectral differences. Therefore, they are useful to find out experimental conditions where the spectrochromatograms can be recovered by deconvolution. Two-way multivariate selectivity yielded the best performance and was applied to the separation using diode-array detection of a mixture of 25 phenolic compounds, which remained unresolved in the chromatographic order using linear and multi-linear gradients of acetonitrile-water. Peak deconvolution was carried out using the combination of orthogonal projection approach and alternating least squares. Copyright © 2014 Elsevier B.V. All rights reserved.

Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device.

Science.gov (United States)

Hahn, Paul; Carrasco-Zevallos, Oscar; Cunefare, David; Migacz, Justin; Farsiu, Sina; Izatt, Joseph A; Toth, Cynthia A

2015-07-01

To characterize the first in-human intraoperative imaging using a custom prototype spectral-domain microscope-integrated optical coherence tomography (MIOCT) device during vitreoretinal surgery with instruments in the eye. Under institutional review board approval for a prospective intraoperative study, MIOCT images were obtained at surgical pauses with instruments held static in the vitreous cavity and then concurrently with surgical maneuvers. Postoperatively, MIOCT images obtained at surgical pauses were compared with images obtained with a high-resolution handheld spectral-domain OCT (HHOCT) system with objective endpoints, including acquisition of images acceptable for analysis and identification of predefined macular morphologic or pathologic features. Human MIOCT images were successfully obtained before incision and during pauses in surgical maneuvers. MIOCT imaging confirmed preoperative diagnoses, such as epiretinal membrane, full-thickness macular hole, and vitreomacular traction and demonstrated successful achievement of surgical goals. MIOCT and HHOCT images obtained at surgical pauses in two cohorts of five patients were comparable with greater than or equal to 80% correlation in 80% of patients. Real-time video-imaging concurrent with surgical manipulations enabled, for the first time using this device, visualization of dynamic instrument-retina interaction with targeted OCT tracking. MIOCT is successful for imaging at surgical pauses and for real-time image guidance with implementation of targeted OCT tracking. Even faster acquisition speeds are currently being developed with incorporation of a swept-source MIOCT engine. Further refinements and investigations will be directed toward continued integration for real-time volumetric imaging of surgical maneuvers. Ongoing development of seamless MIOCT systems will likely transform surgical visualization, approaches, and decision-making.

SMART-X: Square Meter, Arcsecond Resolution Telescope for X-rays

Science.gov (United States)

Vikhlinin, Alexey; SMART-X Collaboration

2013-04-01

SMART-X is a concept for a next-generation X-ray observatory with large-area, 0.5" angular resolution grazing incidence adjustable X-ray mirrors, high-throughput critical angle transmission gratings, and X-ray microcalorimeter and CMOS-based imager in the focal plane. High angular resolution is enabled by new technology based on controlling the shape of mirror segments using thin film piezo actuators deposited on the back surface. Science applications include observations of growth of supermassive black holes since redshifts of ~10, ultra-deep surveys over 10's of square degrees, galaxy assembly at z=2-3, as well as new opportunities in the high-resolution X-ray spectroscopy and time domains. We also review the progress in technology development, tests, and mission design over the past year.

The high throughput virtual slit enables compact, inexpensive Raman spectral imagers

Science.gov (United States)

Gooding, Edward; Deutsch, Erik R.; Huehnerhoff, Joseph; Hajian, Arsen R.

2018-02-01

Raman spectral imaging is increasingly becoming the tool of choice for field-based applications such as threat, narcotics and hazmat detection; air, soil and water quality monitoring; and material ID. Conventional fiber-coupled point source Raman spectrometers effectively interrogate a small sample area and identify bulk samples via spectral library matching. However, these devices are very slow at mapping over macroscopic areas. In addition, the spatial averaging performed by instruments that collect binned spectra, particularly when used in combination with orbital raster scanning, tends to dilute the spectra of trace particles in a mixture. Our design, employing free space line illumination combined with area imaging, reveals both the spectral and spatial content of heterogeneous mixtures. This approach is well suited to applications such as detecting explosives and narcotics trace particle detection in fingerprints. The patented High Throughput Virtual Slit1 is an innovative optical design that enables compact, inexpensive handheld Raman spectral imagers. HTVS-based instruments achieve significantly higher spectral resolution than can be obtained with conventional designs of the same size. Alternatively, they can be used to build instruments with comparable resolution to large spectrometers, but substantially smaller size, weight and unit cost, all while maintaining high sensitivity. When used in combination with laser line imaging, this design eliminates sample photobleaching and unwanted photochemistry while greatly enhancing mapping speed, all with high selectivity and sensitivity. We will present spectral image data and discuss applications that are made possible by low cost HTVS-enabled instruments.

Ultra-short laser pulses. Petawatt and femtosecond

International Nuclear Information System (INIS)

Lemoine, P.

1999-01-01

This book deals with a series of new results obtained thanks to the use of ultra-short laser pulses. This branch of physics has made incredible progresses during the last 25 years. Ultra-short laser pulses offer the opportunity to explore the domain of ultra-high energies and of ultra-short duration events. Applications are various, from controlled nuclear fusion to eye surgery and to more familiar industrial applications such as electronics. (J.S.)

Small Pitch Transition-Edge Sensors with Broadband High Spectral Resolution for Solar Physics

Science.gov (United States)

Smith, S. J.; Adams, J. S.; Eckart, M. E.; Smith, Adams; Bailey, C. N.; Bandler, S. R.; Chevenak, J. A.; Finkbeiner, F. M.; Kelley, R. L.; Kilbourne, C. A.;

Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software

DEFF Research Database (Denmark)

Sander, Birgit; Ahmad Al-Abiji, Hajer; Kofod, Mads

2015-01-01

Purpose Spectral-domain optical coherence tomographies (OCTs) from different companies do not give identical retinal thicknesses. The purpose of this study was to evaluate if differences in thickness when using a spectral domain Cirrus OCT or a Heidelberg Spectralis are due to hardware difference...

Ultra high energy gamma-ray astronomy

International Nuclear Information System (INIS)

Wdowczyk, J.

1986-01-01

The experimental data on ultra high energy γ-rays are reviewed and a comparison of the properties of photon and proton initiated shower is made. The consequences of the existence of the strong ultra high energy γ-ray sources for other observations is analysed and possible mechanisms for the production of ultra high energy γ-rays in the sources are discussed. It is demonstrated that if the γ-rays are produced via cosmic ray interactions the sources have to produce very high fluxes of cosmic ray particles. In fact it is possible that a small number of such sources can supply the whole Galactic cosmic ray flux

Mnemonic discrimination relates to perforant path integrity: An ultra-high resolution diffusion tensor imaging study.

Science.gov (United States)

Bennett, Ilana J; Stark, Craig E L

2016-03-01

Pattern separation describes the orthogonalization of similar inputs into unique, non-overlapping representations. This computational process is thought to serve memory by reducing interference and to be mediated by the dentate gyrus of the hippocampus. Using ultra-high in-plane resolution diffusion tensor imaging (hrDTI) in older adults, we previously demonstrated that integrity of the perforant path, which provides input to the dentate gyrus from entorhinal cortex, was associated with mnemonic discrimination, a behavioral outcome designed to load on pattern separation. The current hrDTI study assessed the specificity of this perforant path integrity-mnemonic discrimination relationship relative to other cognitive constructs (identified using a factor analysis) and white matter tracts (hippocampal cingulum, fornix, corpus callosum) in 112 healthy adults (20-87 years). Results revealed age-related declines in integrity of the perforant path and other medial temporal lobe (MTL) tracts (hippocampal cingulum, fornix). Controlling for global effects of brain aging, perforant path integrity related only to the factor that captured mnemonic discrimination performance. Comparable integrity-mnemonic discrimination relationships were also observed for the hippocampal cingulum and fornix. Thus, whereas perforant path integrity specifically relates to mnemonic discrimination, mnemonic discrimination may be mediated by a broader MTL network. Copyright © 2015 Elsevier Inc. All rights reserved.

The effect of cognitive remediation in individuals at ultra-high risk for psychosis

DEFF Research Database (Denmark)

Glenthøj, Louise Birkedal; Hjorthøj, Carsten; Kristensen, Tina Dam

2017-01-01

of five studies that reported a cognitive outcome found cognitive remediation to improve cognition in the domains of verbal memory, attention, and processing speed. Two out of four studies that reported on functional outcome found cognitive remediation to improve the functional outcome in the domains...... of social functioning and social adjustment. Zero out of the five studies that reported such an outcome found cognitive remediation to affect the magnitude of clinical symptoms. Research on the effect of cognitive remediation in the ultra-high risk state is still scarce. The current state of evidence...

High resolution solar observations from first principles to applications

Science.gov (United States)

Verdoni, Angelo P.

2009-10-01

The expression "high-resolution observations" in Solar Physics refers to the spatial, temporal and spectral domains in their entirety. High-resolution observations of solar fine structure are a necessity to answer many of the intriguing questions related to solar activity. However, a researcher building instruments for high-resolution observations has to cope with the fact that these three domains often have diametrically opposed boundary conditions. Many factors have to be considered in the design of a successful instrument. Modern post-focus instruments are more closely linked with the solar telescopes that they serve than in past. In principle, the quest for high-resolution observations already starts with the selection of the observatory site. The site survey of the Advanced Technology Solar Telescope (ATST) under the stewardship of the National Solar Observatory (NSO) has identified Big Bear Solar Observatory (BBSO) as one of the best sites for solar observations. In a first step, the seeing characteristics at BBSO based on the data collected for the ATST site survey are described. The analysis will aid in the scheduling of high-resolution observations at BBSO as well as provide useful information concerning the design and implementation of a thermal control system for the New Solar Telescope (NST). NST is an off-axis open-structure Gregorian-style telescope with a 1.6 m aperture. NST will be housed in a newly constructed 5/8-sphere ventilated dome. With optics exposed to the surrounding air, NST's open-structure design makes it particularly vulnerable to the effects of enclosure-related seeing. In an effort to mitigate these effects, the initial design of a thermal control system for the NST dome is presented. The goal is to remediate thermal related seeing effects present within the dome interior. The THermal Control System (THCS) is an essential component for the open-telescope design of NST to work. Following these tasks, a calibration routine for the

High-Resolution Sonars: What Resolution Do We Need for Target Recognition?

Directory of Open Access Journals (Sweden)

Pailhas Yan

2010-01-01

Full Text Available Target recognition in sonar imagery has long been an active research area in the maritime domain, especially in the mine-counter measure context. Recently it has received even more attention as new sensors with increased resolution have been developed; new threats to critical maritime assets and a new paradigm for target recognition based on autonomous platforms have emerged. With the recent introduction of Synthetic Aperture Sonar systems and high-frequency sonars, sonar resolution has dramatically increased and noise levels decreased. Sonar images are distance images but at high resolution they tend to appear visually as optical images. Traditionally algorithms have been developed specifically for imaging sonars because of their limited resolution and high noise levels. With high-resolution sonars, algorithms developed in the image processing field for natural images become applicable. However, the lack of large datasets has hampered the development of such algorithms. Here we present a fast and realistic sonar simulator enabling development and evaluation of such algorithms.We develop a classifier and then analyse its performances using our simulated synthetic sonar images. Finally, we discuss sensor resolution requirements to achieve effective classification of various targets and demonstrate that with high resolution sonars target highlight analysis is the key for target recognition.

Survey of Ultra-wideband Radar

Science.gov (United States)

Mokole, Eric L.; Hansen, Pete

The development of UWB radar over the last four decades is very briefly summarized. A discussion of the meaning of UWB is followed by a short history of UWB radar developments and discussions of key supporting technologies and current UWB radars. Selected UWB radars and the associated applications are highlighted. Applications include detecting and imaging buried mines, detecting and mapping underground utilities, detecting and imaging objects obscured by foliage, through-wall detection in urban areas, short-range detection of suicide bombs, and the characterization of the impulse responses of various artificial and naturally occurring scattering objects. In particular, the Naval Research Laboratory's experimental, low-power, dual-polarized, short-pulse, ultra-high resolution radar is used to discuss applications and issues of UWB radar. Some crucial issues that are problematic to UWB radar are spectral availability, electromagnetic interference and compatibility, difficulties with waveform control/shaping, hardware limitations in the transmission chain, and the unreliability of high-power sources for sustained use above 2 GHz.

NanoComposite Polymers for High Resolution Near Infrared Detectors

Data.gov (United States)

National Aeronautics and Space Administration — Develop nanocomposite materials with tuned refractive index in the near infra red spectral range as an index-matched immersion lens for high resolution infra-red...

Enhanced spectral resolution by high-dimensional NMR using the filter diagonalization method and “hidden” dimensions

Science.gov (United States)

Meng, Xi; Nguyen, Bao D.; Ridge, Clark; Shaka, A. J.

2009-01-01

High-dimensional (HD) NMR spectra have poorer digital resolution than low-dimensional (LD) spectra, for a fixed amount of experiment time. This has led to “reduced-dimensionality” strategies, in which several LD projections of the HD NMR spectrum are acquired, each with higher digital resolution; an approximate HD spectrum is then inferred by some means. We propose a strategy that moves in the opposite direction, by adding more time dimensions to increase the information content of the data set, even if only a very sparse time grid is used in each dimension. The full HD time-domain data can be analyzed by the Filter Diagonalization Method (FDM), yielding very narrow resonances along all of the frequency axes, even those with sparse sampling. Integrating over the added dimensions of HD FDM NMR spectra reconstitutes LD spectra with enhanced resolution, often more quickly than direct acquisition of the LD spectrum with a larger number of grid points in each of the fewer dimensions. If the extra dimensions do not appear in the final spectrum, and are used solely to boost information content, we propose the moniker hidden-dimension NMR. This work shows that HD peaks have unmistakable frequency signatures that can be detected as single HD objects by an appropriate algorithm, even though their patterns would be tricky for a human operator to visualize or recognize, and even if digital resolution in an HD FT spectrum is very coarse compared with natural line widths. PMID:18926747

Assessing and monitoring of urban vegetation using multiple endmember spectral mixture analysis

Science.gov (United States)

Zoran, M. A.; Savastru, R. S.; Savastru, D. M.

2013-08-01

During last years urban vegetation with significant health, biological and economical values had experienced dramatic changes due to urbanization and human activities in the metropolitan area of Bucharest in Romania. We investigated the utility of remote sensing approaches of multiple endmember spectral mixture analysis (MESMA) applied to IKONOS and Landsat TM/ETM satellite data for estimating fractional cover of urban/periurban forest, parks, agricultural vegetation areas. Because of the spectral heterogeneity of same physical features of urban vegetation increases with the increase of image resolution, the traditional spectral information-based statistical method may not be useful to classify land cover dynamics from high resolution imageries like IKONOS. So we used hierarchy tree classification method in classification and MESMA for vegetation land cover dynamics assessment based on available IKONOS high-resolution imagery of Bucharest town. This study employs thirty two endmembers and six hundred and sixty spectral models to identify all Earth's features (vegetation, water, soil, impervious) and shade in the Bucharest area. The mean RMS error for the selected vegetation land cover classes range from 0.0027 to 0.018. The Pearson correlation between the fraction outputs from MESMA and reference data from all IKONOS images 1m panchromatic resolution data for urban/periurban vegetation were ranging in the domain 0.7048 - 0.8287. The framework in this study can be applied to other urban vegetation areas in Romania.

Development and testing of a fast Fourier transform high dynamic-range spectral diagnostics for millimeter wave characterization

International Nuclear Information System (INIS)

Thoen, D. J.; Bongers, W. A.; Westerhof, E.; Baar, M. R. de; Berg, M. A. van den; Beveren, V. van; Goede, A. P. H.; Graswinckel, M. F.; Schueller, F. C.; Oosterbeek, J. W.; Buerger, A.; Hennen, B. A.

2009-01-01

A fast Fourier transform (FFT) based wide range millimeter wave diagnostics for spectral characterization of scattered millimeter waves in plasmas has been successfully brought into operation. The scattered millimeter waves are heterodyne downconverted and directly digitized using a fast analog-digital converter and a compact peripheral component interconnect computer. Frequency spectra are obtained by FFT in the time domain of the intermediate frequency signal. The scattered millimeter waves are generated during high power electron cyclotron resonance heating experiments on the TEXTOR tokamak and demonstrate the performance of the diagnostics and, in particular, the usability of direct digitizing and Fourier transformation of millimeter wave signals. The diagnostics is able to acquire 4 GHz wide spectra of signals in the range of 136-140 GHz. The rate of spectra is tunable and has been tested between 200 000 spectra/s with a frequency resolution of 100 MHz and 120 spectra/s with a frequency resolution of 25 kHz. The respective dynamic ranges are 52 and 88 dB. Major benefits of the new diagnostics are a tunable time and frequency resolution due to postdetection, near-real time processing of the acquired data. This diagnostics has a wider application in astrophysics, earth observation, plasma physics, and molecular spectroscopy for the detection and analysis of millimeter wave radiation, providing high-resolution spectra at high temporal resolution and large dynamic range.

Advancing Atmosphere-Ocean Remote Sensing with Spaceborne High Spectral Resolution Lidar

Science.gov (United States)

Hostetler, C. A.; Behrenfeld, M. J.; Chepfer, H.; Hu, Y.; Hair, J. W.; Trepte, C. R.; Winker, D. M.; Ferrare, R. A.; Burton, S. P.; Scarino, A. J.; Powell, K. A.; Michaud, J.

2016-12-01

More than 1600 publications employing observations from the CALIOP lidar on CALIPSO testify to the value of spaceborne lidar for aerosol and cloud remote sensing. Recent publications have shown the value of CALIOP data for retrievals of key ocean carbon cycle stocks. In this presentation we focus on the advantages of a more advanced technique, High Spectral Resolution Lidar (HSRL), for aerosol, cloud, and ocean remote sensing. An atmosphere-ocean optimized HSRL achieves greater accuracy over the standard backscatter lidar technique for retrievals of aerosol and cloud extinction and backscatter profiles, provides additional capability to retrieve aerosol and cloud microphysical parameters, and enables vertically-resolved characterization of scattering and absorption properties of suspended and dissolved materials in the ocean. Numerous publications highlight the synergy of coincident CALIOP and passive A-train observations for studies of aerosol-cloud radiative effects and cloud-climate feedback. Less appreciated is the complementarity that would exist between an optimized spaceborne lidar and passive ocean color. An optimized HSRL flown in formation with the Plankton, Aerosol, and ocean Ecosystem (PACE) mission would provide phytoplankton vertical distribution, which is needed for accurately estimating net primary productivity but absent in the PACE ocean color data. The HSRL would also provide data needed to improve atmospheric correction schemes in ocean color retrievals. Because lidar provides measurements both night and day, through tenuous clouds and aerosol layers, and in holes between clouds, the sampling achieved is highly complementary to passive radiometry, providing data in important high latitude regions where ocean color data are sparse or nonexistent. In this presentation we will discuss 1) relevant aerosol, cloud, and ocean retrievals from airborne HSRL field missions; 2) the advantages of an optimized spaceborne HSRL for aerosol, cloud, and ocean

High-resolution flood modeling of urban areas using MSN_Flood

Directory of Open Access Journals (Sweden)

Michael Hartnett

2017-07-01

Full Text Available Although existing hydraulic models have been used to simulate and predict urban flooding, most of these models are inadequate due to the high spatial resolution required to simulate flows in urban floodplains. Nesting high-resolution subdomains within coarser-resolution models is an efficient solution for enabling simultaneous calculation of flooding due to tides, surges, and high river flows. MSN_Flood has been developed to incorporate moving boundaries around nested domains, permitting alternate flooding and drying along the boundary and in the interior of the domain. Ghost cells adjacent to open boundary cells convert open boundaries, in effect, into internal boundaries. The moving boundary may be multi-segmented and non-continuous, with recirculating flow across the boundary. When combined with a bespoke adaptive interpolation scheme, this approach facilitates a dynamic internal boundary. Based on an alternating-direction semi-implicit finite difference scheme, MSN_Flood was used to hindcast a major flood event in Cork City resulting from the combined pressures of fluvial, tidal, and storm surge processes. The results show that the model is computationally efficient, as the 2-m high-resolution nest is used only in the urban flooded region. Elsewhere, lower-resolution nests are used. The results also show that the model is highly accurate when compared with measured data. The model is capable of incorporating nested sub-domains when the nested boundary is multi-segmented and highly complex with lateral gradients of elevation and velocities. This is a major benefit when modelling urban floodplains at very high resolution.

Improved image quality and diagnostic potential using ultra-high-resolution computed tomography of the lung with small scan FOV: A prospective study.

Directory of Open Access Journals (Sweden)

Huiyuan Zhu

Full Text Available The aim of this study was to assess whether CT imaging using an ultra-high-resolution CT (UHRCT scan with a small scan field of view (FOV provides higher image quality and helps to reduce the follow-up period compared with a conventional high-resolution CT (CHRCT scan. We identified patients with at least one pulmonary nodule at our hospital from July 2015 to November 2015. CHRCT and UHRCT scans were conducted in all enrolled patients. Three experienced radiologists evaluated the image quality using a 5-point score and made diagnoses. The paired images were displayed side by side in a random manner and annotations of scan information were removed. The following parameters including image quality, diagnostic confidence of radiologists, follow-up recommendations and diagnostic accuracy were assessed. A total of 52 patients (62 nodules were included in this study. UHRCT scan provides a better image quality regarding the margin of nodules and solid internal component compared to that of CHRCT (P 0.05. These findings suggest that the UHRCT prototype scanner provides a better image quality of subsolid nodules compared to CHRCT and contributes significantly to reduce the patients' follow-up period.

An Ultra-high Resolution Synthetic Precipitation Data for Ungauged Sites

Science.gov (United States)

Kim, Hong-Joong; Choi, Kyung-Min; Oh, Jai-Ho

2018-05-01

Despite the enormous damage caused by record heavy rainfall, the amount of precipitation in areas without observation points cannot be known precisely. One way to overcome these difficulties is to estimate meteorological data at ungauged sites. In this study, we have used observation data over Seoul city to calculate high-resolution (250-meter resolution) synthetic precipitation over a 10-year (2005-2014) period. Furthermore, three cases are analyzed by evaluating the rainfall intensity and performing statistical analysis over the 10-year period. In the case where the typhoon "Meari" passed to the west coast during 28-30 June 2011, the Pearson correlation coefficient was 0.93 for seven validation points, which implies that the temporal correlation between the observed precipitation and synthetic precipitation was very good. It can be confirmed that the time series of observation and synthetic precipitation in the period almost completely matches the observed rainfall. On June 28-29, 2011, the estimation of 10 to 30 mm h-1 of continuous strong precipitation was correct. In addition, it is shown that the synthetic precipitation closely follows the observed precipitation for all three cases. Statistical analysis of 10 years of data reveals a very high correlation coefficient between synthetic precipitation and observed rainfall (0.86). Thus, synthetic precipitation data show good agreement with the observations. Therefore, the 250-m resolution synthetic precipitation amount calculated in this study is useful as basic data in weather applications, such as urban flood detection.

Refinement procedure for the image alignment in high-resolution electron tomography.

Science.gov (United States)

Houben, L; Bar Sadan, M

2011-01-01

High-resolution electron tomography from a tilt series of transmission electron microscopy images requires an accurate image alignment procedure in order to maximise the resolution of the tomogram. This is the case in particular for ultra-high resolution where even very small misalignments between individual images can dramatically reduce the fidelity of the resultant reconstruction. A tomographic-reconstruction based and marker-free method is proposed, which uses an iterative optimisation of the tomogram resolution. The method utilises a search algorithm that maximises the contrast in tomogram sub-volumes. Unlike conventional cross-correlation analysis it provides the required correlation over a large tilt angle separation and guarantees a consistent alignment of images for the full range of object tilt angles. An assessment based on experimental reconstructions shows that the marker-free procedure is competitive to the reference of marker-based procedures at lower resolution and yields sub-pixel accuracy even for simulated high-resolution data. Copyright © 2011 Elsevier B.V. All rights reserved.

Do ultra-orphan medicinal products warrant ultra-high prices? A review

Directory of Open Access Journals (Sweden)

Picavet E

2013-06-01

Full Text Available Eline Picavet,1 David Cassiman,2 Steven Simoens1 1Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; 2Department of Hepatology, University Hospital Leuven, Leuven, Belgium Abstract: Ultra-orphan medicinal products (ultra-OMPs are intended for the treatment, prevention, or diagnosis of ultra-rare diseases, ie, life-threatening or chronically debilitating diseases that affect less than one per 50,000 individuals. Recently, high prices for ultra-OMPs have given rise to debate on the sustainability and justification of these prices. The aim of this article is to review the international scientific literature on the pricing of ultra-OMPs and to provide an overview of the current knowledge on the drivers of ultra-OMP pricing. The pricing process of ultra-OMPs is a complex and nontransparent issue. Evidence in the literature seems to indicate that ultra-OMPs are priced according to rarity and what the manufacturer believes the market will bear. Additionally, there appears to be a trend between the price of an ultra-OMP and the number of available alternatives. Patients, third-party payers, and pharmaceutical companies could benefit from more transparent pricing strategies. With a view to containing health care costs, it is likely that cost-sharing strategies, such as performance-based risk sharing arrangements, will become increasingly more important. However, it is vital that any measures for price control are consistent with the intended goals of the incentives to promote the development of new OMPs. Ideally, a balance must be struck between attaining affordable prices for ultra-OMPs and securing a realistic return on investment for the pharmaceutical industry. Keywords: ultra-orphan medicinal product, ultra-rare disease, pricing

Spectral domain, common path OCT in a handheld PIC based system

Science.gov (United States)

Leinse, Arne; Wevers, Lennart; Marchenko, Denys; Dekker, Ronald; Heideman, René G.; Ruis, Roosje M.; Faber, Dirk J.; van Leeuwen, Ton G.; Kim, Keun Bae; Kim, Kyungmin

2018-02-01

Optical Coherence Tomography (OCT) has made it into the clinic in the last decade with systems based on bulk optical components. The next disruptive step will be the introduction of handheld OCT systems. Photonic Integrated Circuit (PIC) technology is the key enabler for this further miniaturization. PIC technology allows signal processing on a stable platform and the implementation of a common path interferometer in that same platform creates a robust fully integrated OCT system with a flexible fiber probe. In this work the first PIC based handheld and integrated common path based spectral domain OCT system is described and demonstrated. The spectrometer in the system is based on an Arrayed Waveguide Grating (AWG) and fully integrated with the CCD and a fiber probe into a system operating at 850 nm. The AWG on the PIC creates a 512 channel spectrometer with a resolution of 0.22 nm enabling a high speed analysis of the full A-scan. The silicon nitride based proprietary waveguide technology (TriPleXTM) enables low loss complex photonic structures from the visible (405 nm) to IR (2350 nm) range, making it a unique candidate for OCT applications. Broadband AWG operation from visible to 1700 nm has been shown in the platform and Photonic Design Kits (PDK) are available enabling custom made designs in a system level design environment. This allows a low threshold entry for designing new (OCT) designs for a broad wavelength range.

Atomic resolution imaging of ferroelectric domains

International Nuclear Information System (INIS)

Bursill, L.A.

1997-01-01

Electron optical principles involved in obtaining atomic resolution images of ferroelectric domains are reviewed, including the methods available to obtain meaningful interpretation and analysis of the image detail in terms of the atomic structures. Recent work is concerned with establishing the relationship between the essentially static chemical nanodomains and the spatial and temporal fluctuations of the nanoscale polar domains present in the relaxor class of materials, including lead scandium tantalate (PST) and lead magnesium niobate (PMN). Correct interpretation of the images required use of Next Nearest Neighbour Ising model simulations for the chemical domain textures upon which we must superimpose the polar domain textures; an introduction to this work is presented. A thorough analysis of the atomic scale chemical inhomogeneities, based upon the HRTEM results, has lead to an improved formulation of the theory of the dielectric response of PMN and PST, which is capable to predict the observed temperature and frequency dependence. HRTEM may be combined with solid state and statistical physics principles to provide a deeper understanding of structure/property relationships. 15 refs., 6 figs

High-resolution 3-μm spectra of Jupiter: Latitudinal spectral variations influenced by molecules, clouds, and haze

Science.gov (United States)

Kim, Sang J.; Geballe, T. R.; Kim, J. H.; Jung, A.; Seo, H. J.; Minh, Y. C.

2010-08-01

We present latitudinally-resolved high-resolution ( R = 37,000) pole-to-pole spectra of Jupiter in various narrow longitudinal ranges, in spectral intervals covering roughly half of the spectral range 2.86-3.53 μm. We have analyzed the data with the aid of synthetic spectra generated from a model jovian atmosphere that included lines of CH 4, CH 3D, NH 3, C 2H 2, C 2H 6, PH 3, and HCN, as well as clouds and haze. Numerous spectral features of many of these molecular species are present and are individually identified for the first time, as are many lines of H3+ and a few unidentified spectral features. In both polar regions the 2.86-3.10-μm continuum is more than 10 times weaker than in spectra at lower latitudes, implying that in this wavelength range the single-scattering albedos of polar haze particles are very low. In contrast, the 3.24-3.53 μm the weak polar and equatorial continua are of comparable intensity. We derive vertical distributions of NH 3, C 2H 2 and C 2H 6, and find that the mixing ratios of NH 3 and C 2H 6 show little variation between equatorial and polar regions. However, the mixing ratios of C 2H 2 in the northern and southern polar regions are ˜6 and ˜3 times, respectively, less than those in the equatorial regions. The derived mixing ratio curves of C 2H 2 and C 2H 6 extend up to the 10 -6 bar level, a significantly higher altitude than most previous results in the literature. Further ground-based observations covering other longitudes are needed to test if these mixing ratios are representative values for the equatorial and polar regions.

Extending the Effective Ranging Depth of Spectral Domain Optical Coherence Tomography by Spatial Frequency Domain Multiplexing

Directory of Open Access Journals (Sweden)

Tong Wu

2016-11-01

Full Text Available We present a spatial frequency domain multiplexing method for extending the imaging depth range of a spectral domain optical coherence tomography (SDOCT system without any expensive device. This method uses two galvo scanners with different pivot-offset distances in two independent reference arms for spatial frequency modulation and multiplexing. The spatial frequency contents corresponding to different depth regions of the sample can be shifted to different frequency bands. The spatial frequency domain multiplexing SDOCT system provides an approximately 1.9-fold increase in the effective ranging depth compared with that of a conventional full-range SDOCT system. The reconstructed images of phantom and biological tissue demonstrate the expected increase in ranging depth. The parameters choice criterion for this method is discussed.

10th and 11th conference on Ultra-Wideband Short-Pulse Electromagnetics

CERN Document Server

Mokole, Eric; UWB SP 10; UWB SP 11

2014-01-01

This book presents contributions of deep technical content and high scientific quality in the areas of electromagnetic theory, scattering, UWB antennas, UWB systems, ground penetrating radar (GPR), UWB communications, pulsed-power generation, time-domain computational electromagnetics, UWB compatibility, target detection and discrimination, propagation through dispersive media, and wavelet and multi-resolution techniques. Ultra-wideband (UWB), short-pulse (SP) electromagnetics are now being used for an increasingly wide variety of applications, including collision avoidance radar, concealed object detection, and communications. Notable progress in UWB and SP technologies has been achieved by investigations of their theoretical bases and improvements in solid-state manufacturing, computers, and digitizers. UWB radar systems are also being used for mine clearing, oil pipeline inspections, archeology, geology, and electronic effects testing. Like previous books in this series, Ultra-Wideband Short-Pulse Electrom...

Spectral analysis of point-vortex dynamics: first application to vortex polygons in a circular domain

International Nuclear Information System (INIS)

Speetjens, M F M; Meleshko, V V; Van Heijst, G J F

2014-01-01

The present study addresses the classical problem of the dynamics and stability of a cluster of N-point vortices of equal strength arranged in a polygonal configuration (‘N-vortex polygons’). In unbounded domains, such N-vortex polygons are unconditionally stable for N⩽7. Confinement in a circular domain tightens the stability conditions to N⩽6 and a maximum polygon size relative to the domain radius. This work expands on existing studies on stability and integrability by a first giving an exploratory spectral analysis of the dynamics of N vortex polygons in circular domains. Key to this is that the spectral signature of the time evolution of vortex positions reflects their qualitative behaviour. Expressing vortex motion by a generic evolution operator (the so-called Koopman operator) provides a rigorous framework for such spectral analyses. This paves the way to further differentiation and classification of point-vortex behaviour beyond stability and integrability. The concept of Koopman-based spectral analysis is demonstrated for N-vortex polygons. This reveals that conditional stability can be seen as a local form of integrability and confirms an important generic link between spectrum and dynamics: discrete spectra imply regular (quasi-periodic) motion; continuous (sub-)spectra imply chaotic motion. Moreover, this exposes rich nonlinear dynamics as intermittency between regular and chaotic motion and quasi-coherent structures formed by chaotic vortices. (ss 1)

Cochlear Implant Electrode Localization Using an Ultra-High Resolution Scan Mode on Conventional 64-Slice and New Generation 192-Slice Multi-Detector Computed Tomography.

Science.gov (United States)

Carlson, Matthew L; Leng, Shuai; Diehn, Felix E; Witte, Robert J; Krecke, Karl N; Grimes, Josh; Koeller, Kelly K; Bruesewitz, Michael R; McCollough, Cynthia H; Lane, John I

2017-08-01

A new generation 192-slice multi-detector computed tomography (MDCT) clinical scanner provides enhanced image quality and superior electrode localization over conventional MDCT. Currently, accurate and reliable cochlear implant electrode localization using conventional MDCT scanners remains elusive. Eight fresh-frozen cadaveric temporal bones were implanted with full-length cochlear implant electrodes. Specimens were subsequently scanned with conventional 64-slice and new generation 192-slice MDCT scanners utilizing ultra-high resolution modes. Additionally, all specimens were scanned with micro-CT to provide a reference criterion for electrode position. Images were reconstructed according to routine temporal bone clinical protocols. Three neuroradiologists, blinded to scanner type, reviewed images independently to assess resolution of individual electrodes, scalar localization, and severity of image artifact. Serving as the reference standard, micro-CT identified scalar crossover in one specimen; imaging of all remaining cochleae demonstrated complete scala tympani insertions. The 192-slice MDCT scanner exhibited improved resolution of individual electrodes (p implant imaging compared with conventional MDCT. This technology provides important feedback regarding electrode position and course, which may help in future optimization of surgical technique and electrode design.

Modélisation d'impulsions lasers ultra-brèves Résumé Abstract

African Journals Online (AJOL)

AKA Boko

l'emploi de différentes techniques de multiplexage temporel (TDM) et/ ou fréquentiel. (WDM, DWDM) [1]. L'optique ultra-rapide s'établit comme un champ de recherches important ... De plus, ce type d'impulsions présente une grande largeur spectrale due à l'interdépendance des domaines temps-fréquence déduite de la.

Super-resolution reconstruction in frequency, image, and wavelet domains to reduce through-plane partial voluming in MRI

International Nuclear Information System (INIS)

Gholipour, Ali; Afacan, Onur; Scherrer, Benoit; Prabhu, Sanjay P.; Warfield, Simon K.; Aganj, Iman; Sahin, Mustafa

2015-01-01

Purpose: To compare and evaluate the use of super-resolution reconstruction (SRR), in frequency, image, and wavelet domains, to reduce through-plane partial voluming effects in magnetic resonance imaging. Methods: The reconstruction of an isotropic high-resolution image from multiple thick-slice scans has been investigated through techniques in frequency, image, and wavelet domains. Experiments were carried out with thick-slice T2-weighted fast spin echo sequence on the Academic College of Radiology MRI phantom, where the reconstructed images were compared to a reference high-resolution scan using peak signal-to-noise ratio (PSNR), structural similarity image metric (SSIM), mutual information (MI), and the mean absolute error (MAE) of image intensity profiles. The application of super-resolution reconstruction was then examined in retrospective processing of clinical neuroimages of ten pediatric patients with tuberous sclerosis complex (TSC) to reduce through-plane partial voluming for improved 3D delineation and visualization of thin radial bands of white matter abnormalities. Results: Quantitative evaluation results show improvements in all evaluation metrics through super-resolution reconstruction in the frequency, image, and wavelet domains, with the highest values obtained from SRR in the image domain. The metric values for image-domain SRR versus the original axial, coronal, and sagittal images were PSNR = 32.26 vs 32.22, 32.16, 30.65; SSIM = 0.931 vs 0.922, 0.924, 0.918; MI = 0.871 vs 0.842, 0.844, 0.831; and MAE = 5.38 vs 7.34, 7.06, 6.19. All similarity metrics showed high correlations with expert ranking of image resolution with MI showing the highest correlation at 0.943. Qualitative assessment of the neuroimages of ten TSC patients through in-plane and out-of-plane visualization of structures showed the extent of partial voluming effect in a real clinical scenario and its reduction using SRR. Blinded expert evaluation of image resolution in

Super-resolution reconstruction in frequency, image, and wavelet domains to reduce through-plane partial voluming in MRI

Energy Technology Data Exchange (ETDEWEB)

Gholipour, Ali, E-mail: ali.gholipour@childrens.harvard.edu; Afacan, Onur; Scherrer, Benoit; Prabhu, Sanjay P.; Warfield, Simon K. [Department of Radiology, Boston Children’s Hospital, Boston, Massachusetts 02115 and Harvard Medical School, Boston, Massachusetts 02115 (United States); Aganj, Iman [Radiology Department, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts 02129 and Harvard Medical School, Boston, Massachusetts 02115 (United States); Sahin, Mustafa [Department of Neurology, Boston Children’s Hospital, Boston, Massachusetts 02115 and Harvard Medical School, Boston, Massachusetts 02115 (United States)

2015-12-15

Purpose: To compare and evaluate the use of super-resolution reconstruction (SRR), in frequency, image, and wavelet domains, to reduce through-plane partial voluming effects in magnetic resonance imaging. Methods: The reconstruction of an isotropic high-resolution image from multiple thick-slice scans has been investigated through techniques in frequency, image, and wavelet domains. Experiments were carried out with thick-slice T2-weighted fast spin echo sequence on the Academic College of Radiology MRI phantom, where the reconstructed images were compared to a reference high-resolution scan using peak signal-to-noise ratio (PSNR), structural similarity image metric (SSIM), mutual information (MI), and the mean absolute error (MAE) of image intensity profiles. The application of super-resolution reconstruction was then examined in retrospective processing of clinical neuroimages of ten pediatric patients with tuberous sclerosis complex (TSC) to reduce through-plane partial voluming for improved 3D delineation and visualization of thin radial bands of white matter abnormalities. Results: Quantitative evaluation results show improvements in all evaluation metrics through super-resolution reconstruction in the frequency, image, and wavelet domains, with the highest values obtained from SRR in the image domain. The metric values for image-domain SRR versus the original axial, coronal, and sagittal images were PSNR = 32.26 vs 32.22, 32.16, 30.65; SSIM = 0.931 vs 0.922, 0.924, 0.918; MI = 0.871 vs 0.842, 0.844, 0.831; and MAE = 5.38 vs 7.34, 7.06, 6.19. All similarity metrics showed high correlations with expert ranking of image resolution with MI showing the highest correlation at 0.943. Qualitative assessment of the neuroimages of ten TSC patients through in-plane and out-of-plane visualization of structures showed the extent of partial voluming effect in a real clinical scenario and its reduction using SRR. Blinded expert evaluation of image resolution in

Assessment of Spectral and Temporal Resolution in Cochlear Implant Users Using Psychoacoustic Discrimination and Speech Cue Categorization.

Science.gov (United States)

Winn, Matthew B; Won, Jong Ho; Moon, Il Joon

This study was conducted to measure auditory perception by cochlear implant users in the spectral and temporal domains, using tests of either categorization (using speech-based cues) or discrimination (using conventional psychoacoustic tests). The authors hypothesized that traditional nonlinguistic tests assessing spectral and temporal auditory resolution would correspond to speech-based measures assessing specific aspects of phonetic categorization assumed to depend on spectral and temporal auditory resolution. The authors further hypothesized that speech-based categorization performance would ultimately be a superior predictor of speech recognition performance, because of the fundamental nature of speech recognition as categorization. Nineteen cochlear implant listeners and 10 listeners with normal hearing participated in a suite of tasks that included spectral ripple discrimination, temporal modulation detection, and syllable categorization, which was split into a spectral cue-based task (targeting the /ba/-/da/ contrast) and a timing cue-based task (targeting the /b/-/p/ and /d/-/t/ contrasts). Speech sounds were manipulated to contain specific spectral or temporal modulations (formant transitions or voice onset time, respectively) that could be categorized. Categorization responses were quantified using logistic regression to assess perceptual sensitivity to acoustic phonetic cues. Word recognition testing was also conducted for cochlear implant listeners. Cochlear implant users were generally less successful at utilizing both spectral and temporal cues for categorization compared with listeners with normal hearing. For the cochlear implant listener group, spectral ripple discrimination was significantly correlated with the categorization of formant transitions; both were correlated with better word recognition. Temporal modulation detection using 100- and 10-Hz-modulated noise was not correlated either with the cochlear implant subjects' categorization of

High-resolution T{sub 2}-weighted cervical cancer imaging: a feasibility study on ultra-high-field 7.0-T MRI with an endorectal monopole antenna

Energy Technology Data Exchange (ETDEWEB)

Hoogendam, Jacob P.; Verheijen, Rene H.M.; Zweemer, Ronald P. [University Medical Centre Utrecht, Department of Gynaecological Oncology, UMC Utrecht Cancer Centre, PO Box 85500, Utrecht (Netherlands); Kalleveen, Irene M.L.; Castro, Catalina S.A. de; Raaijmakers, Alexander J.E.; Bosch, Maurice A.A.J. van den; Klomp, Dennis W.J.; Veldhuis, Wouter B. [University Medical Centre Utrecht, Department of Radiology, Utrecht (Netherlands)

2017-03-15

We studied the feasibility of high-resolution T{sub 2}-weighted cervical cancer imaging on an ultra-high-field 7.0-T magnetic resonance imaging (MRI) system using an endorectal antenna of 4.7-mm thickness. A feasibility study on 20 stage IB1-IIB cervical cancer patients was conducted. All underwent pre-treatment 1.5-T MRI. At 7.0-T MRI, an external transmit/receive array with seven dipole antennae and a single endorectal monopole receive antenna were used. Discomfort levels were assessed. Following individualised phase-based B{sub 1} {sup +} shimming, T{sub 2}-weighted turbo spin echo sequences were completed. Patients had stage IB1 (n = 9), IB2 (n = 4), IIA1 (n = 1) or IIB (n = 6) cervical cancer. Discomfort (ten-point scale) was minimal at placement and removal of the endorectal antenna with a median score of 1 (range, 0-5) and 0 (range, 0-2) respectively. Its use did not result in adverse events or pre-term session discontinuation. To demonstrate feasibility, T{sub 2}-weighted acquisitions from 7.0-T MRI are presented in comparison to 1.5-T MRI. Artefacts on 7.0-T MRI were due to motion, locally destructive B{sub 1} interference, excessive B{sub 1} under the external antennae and SENSE reconstruction. High-resolution T{sub 2}-weighted 7.0-T MRI of stage IB1-IIB cervical cancer is feasible. The addition of an endorectal antenna is well tolerated by patients. (orig.)

In vivo monitoring laser tissue interaction using high resolution Fourier-domain optical coherence tomography

Science.gov (United States)

Jo, Hang Chan; Shin, Dong Jun; Ahn, Jin-Chul; Chung, Phil-Sang; Kim, DaeYu

2017-02-01

Laser-induced therapies include laser ablation to remove or cut target tissue by irradiating high-power focused laser beam. These laser treatments are widely used tools for minimally invasive surgery and retinal surgical procedures in clinical settings. In this study, we demonstrate laser tissue interaction images of various sample tissues using high resolution Fourier-domain optical coherence tomography (Fd-OCT). We use a Q-switch diode-pumped Nd:YVO4 nanosecond laser (532nm central wavelength) with a 4W maximum output power at a 20 kHz repetition rate to ablate in vitro and in vivo samples including chicken breast and mouse ear tissues. The Fd-OCT system acquires time-series Bscan images at the same location during the tissue ablation experiments with 532nm laser irradiation. The real-time series of OCT cross-sectional (B-scan) images compare structural changes of 532nm laser ablation using same and different laser output powers. Laser tissue ablation is demonstrated by the width and the depth of the tissue ablation from the B-scan images.

A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI.

Science.gov (United States)

Iglesias, Juan Eugenio; Augustinack, Jean C; Nguyen, Khoa; Player, Christopher M; Player, Allison; Wright, Michelle; Roy, Nicole; Frosch, Matthew P; McKee, Ann C; Wald, Lawrence L; Fischl, Bruce; Van Leemput, Koen

2015-07-15

Automated analysis of MRI data of the subregions of the hippocampus requires computational atlases built at a higher resolution than those that are typically used in current neuroimaging studies. Here we describe the construction of a statistical atlas of the hippocampal formation at the subregion level using ultra-high resolution, ex vivo MRI. Fifteen autopsy samples were scanned at 0.13 mm isotropic resolution (on average) using customized hardware. The images were manually segmented into 13 different hippocampal substructures using a protocol specifically designed for this study; precise delineations were made possible by the extraordinary resolution of the scans. In addition to the subregions, manual annotations for neighboring structures (e.g., amygdala, cortex) were obtained from a separate dataset of in vivo, T1-weighted MRI scans of the whole brain (1mm resolution). The manual labels from the in vivo and ex vivo data were combined into a single computational atlas of the hippocampal formation with a novel atlas building algorithm based on Bayesian inference. The resulting atlas can be used to automatically segment the hippocampal subregions in structural MRI images, using an algorithm that can analyze multimodal data and adapt to variations in MRI contrast due to differences in acquisition hardware or pulse sequences. The applicability of the atlas, which we are releasing as part of FreeSurfer (version 6.0), is demonstrated with experiments on three different publicly available datasets with different types of MRI contrast. The results show that the atlas and companion segmentation method: 1) can segment T1 and T2 images, as well as their combination, 2) replicate findings on mild cognitive impairment based on high-resolution T2 data, and 3) can discriminate between Alzheimer's disease subjects and elderly controls with 88% accuracy in standard resolution (1mm) T1 data, significantly outperforming the atlas in FreeSurfer version 5.3 (86% accuracy) and

Comparing spatial tuning curves, spectral ripple resolution, and speech perception in cochlear implant users.

Science.gov (United States)

Anderson, Elizabeth S; Nelson, David A; Kreft, Heather; Nelson, Peggy B; Oxenham, Andrew J

2011-07-01

Spectral ripple discrimination thresholds were measured in 15 cochlear-implant users with broadband (350-5600 Hz) and octave-band noise stimuli. The results were compared with spatial tuning curve (STC) bandwidths previously obtained from the same subjects. Spatial tuning curve bandwidths did not correlate significantly with broadband spectral ripple discrimination thresholds but did correlate significantly with ripple discrimination thresholds when the rippled noise was confined to an octave-wide passband, centered on the STC's probe electrode frequency allocation. Ripple discrimination thresholds were also measured for octave-band stimuli in four contiguous octaves, with center frequencies from 500 Hz to 4000 Hz. Substantial variations in thresholds with center frequency were found in individuals, but no general trends of increasing or decreasing resolution from apex to base were observed in the pooled data. Neither ripple nor STC measures correlated consistently with speech measures in noise and quiet in the sample of subjects in this study. Overall, the results suggest that spectral ripple discrimination measures provide a reasonable measure of spectral resolution that correlates well with more direct, but more time-consuming, measures of spectral resolution, but that such measures do not always provide a clear and robust predictor of performance in speech perception tasks. © 2011 Acoustical Society of America

High Spectral Resolution SOFIA/EXES Observations of C2H2 toward Orion IRc2

Science.gov (United States)

Rangwala, Naseem; Colgan, Sean W. J.; Le Gal, Romane; Acharyya, Kinsuk; Huang, Xinchuan; Lee, Timothy J.; Herbst, Eric; deWitt, Curtis; Richter, Matt; Boogert, Adwin; McKelvey, Mark

2018-03-01

We present high spectral resolution observations from 12.96 to 13.33 microns toward Orion IRc2 using the mid-infrared spectrograph, Echelon-Cross-Echelle Spectrograph (EXES), at Stratospheric Observatory for Infrared Astronomy (SOFIA). These observations probe the physical and chemical conditions of the Orion hot core, which is sampled by a bright, compact, mid-infrared background continuum source in the region, IRc2. All 10 of the rovibrational C2H2 transitions expected in our spectral coverage are detected with high signal-to-noise ratios (S/Ns), yielding continuous coverage of the R-branch lines from J = 9–8 to J = 18–17, including both ortho and para species. Eight of these rovibrational transitions are newly reported detections. The isotopologue, 13CCH2, is clearly detected with a high S/N. This enabled a direct measurement of the 12C/13C isotopic ratio for the Orion hot core of 14 ± 1 and an estimated maximum value of 21. We also detected several HCN rovibrational lines. The ortho and para C2H2 ladders are clearly separate, and tracing two different temperatures, 226 K and 164 K, respectively, with a non-equilibrium ortho to para ratio (OPR) of 1.7 ± 0.1. Additionally, the ortho and para V LSR values differ by about 1.8 ± 0.2 km s‑1, while the mean line widths differ by 0.7 ± 0.2 km s‑1, suggesting that these species are not uniformly mixed along the line of sight to IRc2. We propose that the abnormally low C2H2 OPR could be a remnant from an earlier, colder phase, before the density enhancement (now the hot core) was impacted by shocks generated from an explosive event 500 years ago.

Ultra high resolution SFC-MS as a high throughput platform for metabolic phenotyping: application to metabolic profiling of rat and dog bile.

Science.gov (United States)

Jones, Michael D; Rainville, Paul D; Isaac, Giorgis; Wilson, Ian D; Smith, Norman W; Plumb, Robert S

2014-09-01

Ultra high resolution SFC-MS (on sub-2μm particles) coupled to mass spectrometry has been evaluated for the metabolic profiling of rat and dog bile. The selectivity of the SFC separation differed from that seen in previous reversed-phase UPLC-MS studies on bile, with the order of elution for analytes such as e.g., the bile acids showing many differences. The chromatography system showed excellent stability, reproducibility and robustness with relative standard deviation of less than 1% for retention time obtained over the course of the analysis. SFC showed excellent chromatographic performance with chromatographic peak widths in the order of 3s at the base of the peak. The use of supercritical fluid carbon dioxide as a mobile phase solvent also reduced the overall consumption of organic solvent by a factor of 3 and also reduced the overall analysis time by a factor of 30% compared to reversed-phase gradient LC. SFC-MS appear complementary to RPLC for the metabolic profiling of complex samples such as bile. Copyright © 2014 Elsevier B.V. All rights reserved.

Ultra-Long-Distance Hybrid BOTDA/Ф-OTDR

Directory of Open Access Journals (Sweden)

Yun Fu

2018-03-01

Full Text Available In the distributed optical fiber sensing (DOFS domain, simultaneous measurement of vibration and temperature/strain based on Rayleigh scattering and Brillouin scattering in fiber could have wide applications. However, there are certain challenges for the case of ultra-long sensing range, including the interplay of different scattering mechanisms, the interaction of two types of sensing signals, and the competition of pump power. In this paper, a hybrid DOFS system, which can simultaneously measure temperature/strain and vibration over 150 km, is elaborately designed via integrating the Brillouin optical time-domain analyzer (BOTDA and phase-sensitive optical time-domain reflectometry (Ф-OTDR. Distributed Raman and Brillouin amplifications, frequency division multiplexing (FDM, wavelength division multiplexing (WDM, and time division multiplexing (TDM are delicately fused to accommodate ultra-long-distance BOTDA and Ф-OTDR. Consequently, the sensing range of the hybrid system is 150.62 km, and the spatial resolution of BOTDA and Ф-OTDR are 9 m and 30 m, respectively. The measurement uncertainty of the BOTDA is ± 0.82 MHz. To the best of our knowledge, this is the first time that such hybrid DOFS is realized with a hundred-kilometer length scale.

The spectrometer of the High-Resolution Multi position Thomson Scattering Diagnostic for TJ-II

International Nuclear Information System (INIS)

Herranz, J.; Barth, C. J.; Castejon, F.; Lopez-Sanchez, A.; Mirones, E.; Pastor, I.; Perez, D.; Rodriguez, C.

2001-01-01

Since 1998, a high-resolution multiposition thompson scattering system is in operation at the stellarator TJ-II, combining high accuracy and excellent spatial resolution. A description of the diagnostic spectrometer is presented. The main characteristics of the spectrometer that allow YJ-II Thomson scattering diagnostic to have high spatial and spectral resolution are described in this paper. (Author)

High-resolution flurescence spectroscopy in immunoanalysis

Energy Technology Data Exchange (ETDEWEB)

Grubor, Nenad M. [Iowa State Univ., Ames, IA (United States)

2005-01-01

The work presented in this dissertation combines highly sensitive and selective fluorescence line-narrowing spectroscopy (FLNS) detection with various modes of immunoanalytical techniques. It has been shown that FLNS is capable of directly probing molecules immunocomplexed with antibodies, eliminating analytical ambiguities that may arise from interferences that accompany traditional immunochemical techniques. Moreover, the utilization of highly cross-reactive antibodies for highly specific analyte determination has been demonstrated. Finally, they demonstrate the first example of the spectral resolution of diastereomeric analytes based on their interaction with a cross-reactive antibody.

High frequency dynamics of an isotropic Timoshenko periodic beam by the use of the Time-domain Spectral Finite Element Method

Science.gov (United States)

Żak, A.; Krawczuk, M.; Palacz, M.; Doliński, Ł.; Waszkowiak, W.

2017-11-01

In this work results of numerical simulations and experimental measurements related to the high frequency dynamics of an aluminium Timoshenko periodic beam are presented. It was assumed by the authors that the source of beam structural periodicity comes from periodical alterations to its geometry due to the presence of appropriately arranged drill-holes. As a consequence of these alterations dynamic characteristics of the beam are changed revealing a set of frequency band gaps. The presence of the frequency band gaps can help in the design process of effective sound filters or sound barriers that can selectively attenuate propagating wave signals of certain frequency contents. In order to achieve this a combination of three numerical techniques were employed by the authors. They comprise the application of the Time-domain Spectral Finite Element Method in the case of analysis of finite and semi-infinite computational domains, damage modelling in the case of analysis of drill-hole influence, as well as the Bloch reduction in the case of analysis of periodic computational domains. As an experimental technique the Scanning Laser Doppler Vibrometry was chosen. A combined application of all these numerical and experimental techniques appears as new for this purpose and not reported in the literature available.

An Ultra-low Frequency Modal Testing Suspension System for High Precision Air Pressure Control

Directory of Open Access Journals (Sweden)

Qiaoling YUAN

2014-05-01

Full Text Available As a resolution for air pressure control challenges in ultra-low frequency modal testing suspension systems, an incremental PID control algorithm with dead band is applied to achieve high-precision pressure control. We also develop a set of independent hardware and software systems for high-precision pressure control solutions. Taking control system versatility, scalability, reliability, and other aspects into considerations, a two-level communication employing Ethernet and CAN bus, is adopted to complete such tasks as data exchange between the IPC, the main board and the control board ,and the pressure control. Furthermore, we build a single set of ultra-low frequency modal testing suspension system and complete pressure control experiments, which achieve the desired results and thus confirm that the high-precision pressure control subsystem is reasonable and reliable.

Effect of input spectrum on the spectral switch characteristics in a white-light Michelson interferometer.

Science.gov (United States)

Brundavanam, Maruthi M; Viswanathan, Nirmal K; Rao, D Narayana

2009-12-01

We report here a detailed experimental study to demonstrate the effect of source spectral characteristics such as spectral bandwidth (Deltalambda), peak wavelength (lambda(0)), and shape of the spectrum on the spectral shifts and spectral switches measured due to temporal correlation in a white-light Michelson interferometer operated in the spectral domain. Behavior of the spectral switch characteristics such as the switch position, switch amplitude, and switch symmetry are discussed in detail as a function of optical path difference between the interfering beams. The experimental results are compared with numerical calculations carried out using interference law in the spectral domain with modified source spectral characteristics. On the basis of our results we feel that our study is of critical importance in the selection of source spectral characteristics to further improve the longitudinal resolution or the measurement sensitivity in spectral-domain optical coherence tomography and microscopy.

A spectral analysis of the domain decomposed Monte Carlo method for linear systems

Energy Technology Data Exchange (ETDEWEB)

Slattery, S. R.; Wilson, P. P. H. [Engineering Physics Department, University of Wisconsin - Madison, 1500 Engineering Dr., Madison, WI 53706 (United States); Evans, T. M. [Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN 37830 (United States)

2013-07-01

The domain decomposed behavior of the adjoint Neumann-Ulam Monte Carlo method for solving linear systems is analyzed using the spectral properties of the linear operator. Relationships for the average length of the adjoint random walks, a measure of convergence speed and serial performance, are made with respect to the eigenvalues of the linear operator. In addition, relationships for the effective optical thickness of a domain in the decomposition are presented based on the spectral analysis and diffusion theory. Using the effective optical thickness, the Wigner rational approximation and the mean chord approximation are applied to estimate the leakage fraction of stochastic histories from a domain in the decomposition as a measure of parallel performance and potential communication costs. The one-speed, two-dimensional neutron diffusion equation is used as a model problem to test the models for symmetric operators. In general, the derived approximations show good agreement with measured computational results. (authors)

A spectral analysis of the domain decomposed Monte Carlo method for linear systems

International Nuclear Information System (INIS)

Slattery, S. R.; Wilson, P. P. H.; Evans, T. M.

2013-01-01

The domain decomposed behavior of the adjoint Neumann-Ulam Monte Carlo method for solving linear systems is analyzed using the spectral properties of the linear operator. Relationships for the average length of the adjoint random walks, a measure of convergence speed and serial performance, are made with respect to the eigenvalues of the linear operator. In addition, relationships for the effective optical thickness of a domain in the decomposition are presented based on the spectral analysis and diffusion theory. Using the effective optical thickness, the Wigner rational approximation and the mean chord approximation are applied to estimate the leakage fraction of stochastic histories from a domain in the decomposition as a measure of parallel performance and potential communication costs. The one-speed, two-dimensional neutron diffusion equation is used as a model problem to test the models for symmetric operators. In general, the derived approximations show good agreement with measured computational results. (authors)

Long range surface plasmon resonance with ultra-high penetration depth for self-referenced sensing and ultra-low detection limit using diverging beam approach

Energy Technology Data Exchange (ETDEWEB)

Isaacs, Sivan, E-mail: sivan.isaacs@gmail.com; Abdulhalim, Ibrahim [Department of Electro-Optical Engineering and TheIlse Katz Institute for Nanoscale Science and Technology, Ben Gurion University of the Negev, Beer Sheva 84105 (Israel); NEW CREATE Programme, School of Materials Science and Engineering, 1 CREATE Way, Research Wing, #02-06/08, Singapore 138602 (Singapore)

2015-05-11

Using an insulator-metal-insulator structure with dielectric having refractive index (RI) larger than the analyte, long range surface plasmon (SP) resonance exhibiting ultra-high penetration depth is demonstrated for sensing applications of large bioentities at wavelengths in the visible range. Based on the diverging beam approach in Kretschmann-Raether configuration, one of the SP resonances is shown to shift in response to changes in the analyte RI while the other is fixed; thus, it can be used as a built in reference. The combination of the high sensitivity, high penetration depth and self-reference using the diverging beam approach in which a dark line is detected of the high sensitivity, high penetration depth, self-reference, and the diverging beam approach in which a dark line is detected using large number of camera pixels with a smart algorithm for sub-pixel resolution, a sensor with ultra-low detection limit is demonstrated suitable for large bioentities.

Time-domain induced polarization - an analysis of Cole-Cole parameter resolution and correlation using Markov Chain Monte Carlo inversion

Science.gov (United States)

Madsen, Line Meldgaard; Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

2017-12-01

The application of time-domain induced polarization (TDIP) is increasing with advances in acquisition techniques, data processing and spectral inversion schemes. An inversion of TDIP data for the spectral Cole-Cole parameters is a non-linear problem, but by applying a 1-D Markov Chain Monte Carlo (MCMC) inversion algorithm, a full non-linear uncertainty analysis of the parameters and the parameter correlations can be accessed. This is essential to understand to what degree the spectral Cole-Cole parameters can be resolved from TDIP data. MCMC inversions of synthetic TDIP data, which show bell-shaped probability distributions with a single maximum, show that the Cole-Cole parameters can be resolved from TDIP data if an acquisition range above two decades in time is applied. Linear correlations between the Cole-Cole parameters are observed and by decreasing the acquisitions ranges, the correlations increase and become non-linear. It is further investigated how waveform and parameter values influence the resolution of the Cole-Cole parameters. A limiting factor is the value of the frequency exponent, C. As C decreases, the resolution of all the Cole-Cole parameters decreases and the results become increasingly non-linear. While the values of the time constant, τ, must be in the acquisition range to resolve the parameters well, the choice between a 50 per cent and a 100 per cent duty cycle for the current injection does not have an influence on the parameter resolution. The limits of resolution and linearity are also studied in a comparison between the MCMC and a linearized gradient-based inversion approach. The two methods are consistent for resolved models, but the linearized approach tends to underestimate the uncertainties for poorly resolved parameters due to the corresponding non-linear features. Finally, an MCMC inversion of 1-D field data verifies that spectral Cole-Cole parameters can also be resolved from TD field measurements.

High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S. cerevisiae RNA endonuclease Swt1

International Nuclear Information System (INIS)

Peng, Shuxia; Zhou, Ke; Wang, Wenjia; Gao, Zengqiang; Dong, Yuhui; Liu, Quansheng

2014-01-01

Highlights: • Crystal structure of the C-terminal (CT) domain of Swt1 was determined at 2.3 Å. • Structure of the CT domain was identified as HEPN domain superfamily member. • Low-resolution envelope of Swt1 full-length in solution was analyzed by SAXS. • The middle and CT domains gave good fit to SAXS structural model. - Abstract: Swt1 is an RNA endonuclease that plays an important role in quality control of nuclear messenger ribonucleoprotein particles (mRNPs) in eukaryotes; however, its structural details remain to be elucidated. Here, we report the crystal structure of the C-terminal (CT) domain of Swt1 from Saccharomyces cerevisiae, which shares common characteristics of higher eukaryotes and prokaryotes nucleotide binding (HEPN) domain superfamily. To study in detail the full-length protein structure, we analyzed the low-resolution architecture of Swt1 in solution using small angle X-ray scattering (SAXS) method. Both the CT domain and middle domain exhibited a good fit upon superimposing onto the molecular envelope of Swt1. Our study provides the necessary structural information for detailed analysis of the functional role of Swt1, and its importance in the process of nuclear mRNP surveillance

Refinement procedure for the image alignment in high-resolution electron tomography

International Nuclear Information System (INIS)

Houben, L.; Bar Sadan, M.

2011-01-01

High-resolution electron tomography from a tilt series of transmission electron microscopy images requires an accurate image alignment procedure in order to maximise the resolution of the tomogram. This is the case in particular for ultra-high resolution where even very small misalignments between individual images can dramatically reduce the fidelity of the resultant reconstruction. A tomographic-reconstruction based and marker-free method is proposed, which uses an iterative optimisation of the tomogram resolution. The method utilises a search algorithm that maximises the contrast in tomogram sub-volumes. Unlike conventional cross-correlation analysis it provides the required correlation over a large tilt angle separation and guarantees a consistent alignment of images for the full range of object tilt angles. An assessment based on experimental reconstructions shows that the marker-free procedure is competitive to the reference of marker-based procedures at lower resolution and yields sub-pixel accuracy even for simulated high-resolution data. -- Highlights: → Alignment procedure for electron tomography based on iterative tomogram contrast optimisation. → Marker-free, independent of object, little user interaction. → Accuracy competitive with fiducial marker methods and suited for high-resolution tomography.

High-angular-resolution stellar imaging with occultations from the Cassini spacecraft - III. Mira

Science.gov (United States)

Stewart, Paul N.; Tuthill, Peter G.; Nicholson, Philip D.; Hedman, Matthew M.

2016-04-01

We present an analysis of spectral and spatial data of Mira obtained by the Cassini spacecraft, which not only observed the star's spectra over a broad range of near-infrared wavelengths, but was also able to obtain high-resolution spatial information by watching the star pass behind Saturn's rings. The observed spectral range of 1-5 microns reveals the stellar atmosphere in the crucial water-bands which are unavailable to terrestrial observers, and the simultaneous spatial sampling allows the origin of spectral features to be located in the stellar environment. Models are fitted to the data, revealing the spectral and spatial structure of molecular layers surrounding the star. High-resolution imagery is recovered revealing the layered and asymmetric nature of the stellar atmosphere. The observational data set is also used to confront the state-of-the-art cool opacity-sampling dynamic extended atmosphere models of Mira variables through a detailed spectral and spatial comparison, revealing in general a good agreement with some specific departures corresponding to particular spectral features.

Optically trapped atomic resonant devices for narrow linewidth spectral imaging

Science.gov (United States)

Qian, Lipeng

absorption and fluorescence. The optimum resolution of the fluorescent image is predicted by simulation. Radiation trapping is also shown to be useful for the generation of ultra-narrow linewidth light from an atomic vapor flash lamp. A 2 nanosecond, high voltage pulse is used to excite low pressure mercury vapor mixed with noble gases, producing high intensity emission at the mercury resonant line at 253.7 nm. With a nanosecond pumping time and high electrical current, the radiation intensity of the mercury discharge is increased significantly compared to a normal glow discharge lamp, while simultaneously suppressing the formation of an arc discharge. By avoiding the arc discharge, discrete spectral lines of mercury were kept at narrow bandwidth. Due to radiation trapping, the emission linewidth from the nanosecond mercury lamp decreases with time and produces ultra-narrow linewidth emission 100 ns after of the excitation, this linewidth is verified by absorption measurements through low pressure mercury absorption filter. The lamp is used along with mercury absorption filters for spectroscopic applications, including Filtered Rayleigh Scattering with different CO2 pressures and Raman scattering from methanol.

An Object-Oriented Classification Method on High Resolution Satellite Data

National Research Council Canada - National Science Library

Xiaoxia, Sun; Jixian, Zhang; Zhengjun, Liu

2004-01-01

.... Thereby only the spectral information is used for the classification. High spatial resolution sensors involves a general increase of spatial information and the accuracy of results may decrease on a per-pixel basis...

Improved image quality and diagnostic potential using ultra-high-resolution computed tomography of the lung with small scan FOV: A prospective study.

Science.gov (United States)

Zhu, Huiyuan; Zhang, Lian; Wang, Yali; Hamal, Preeti; You, Xiaofang; Mao, Haixia; Li, Fei; Sun, Xiwen

2017-01-01

The aim of this study was to assess whether CT imaging using an ultra-high-resolution CT (UHRCT) scan with a small scan field of view (FOV) provides higher image quality and helps to reduce the follow-up period compared with a conventional high-resolution CT (CHRCT) scan. We identified patients with at least one pulmonary nodule at our hospital from July 2015 to November 2015. CHRCT and UHRCT scans were conducted in all enrolled patients. Three experienced radiologists evaluated the image quality using a 5-point score and made diagnoses. The paired images were displayed side by side in a random manner and annotations of scan information were removed. The following parameters including image quality, diagnostic confidence of radiologists, follow-up recommendations and diagnostic accuracy were assessed. A total of 52 patients (62 nodules) were included in this study. UHRCT scan provides a better image quality regarding the margin of nodules and solid internal component compared to that of CHRCT (P images than of CHRCT images (Pimages (P 0.05). These findings suggest that the UHRCT prototype scanner provides a better image quality of subsolid nodules compared to CHRCT and contributes significantly to reduce the patients' follow-up period.

High Spectral Resolution Infrared and Raman Lidar Observations for the ARM Program: Clear and Cloudy Sky Applications

Energy Technology Data Exchange (ETDEWEB)

Revercomb, Henry; Tobin, David; Knuteson, Robert; Borg, Lori; Moy, Leslie

2009-06-17

This grant began with the development of the Atmospheric Emitted Radiance Interferometer (AERI) for ARM. The AERI has provided highly accurate and reliable observations of downwelling spectral radiance (Knuteson et al. 2004a, 2004b) for application to radiative transfer, remote sensing of boundary layer temperature and water vapor, and cloud characterization. One of the major contributions of the ARM program has been its success in improving radiation calculation capabilities for models and remote sensing that evolved from the multi-year, clear-sky spectral radiance comparisons between AERI radiances and line-by-line calculations (Turner et al. 2004). This effort also spurred us to play a central role in improving the accuracy of water vapor measurements, again helping ARM lead the way in the community (Turner et al. 2003a, Revercomb et al. 2003). In order to add high-altitude downlooking AERI-like observations over the ARM sites, we began the development of an airborne AERI instrument that has become known as the Scanning High-resolution Interferometer Sounder (Scanning-HIS). This instrument has become an integral part of the ARM Unmanned Aerospace Vehicle (ARM-UAV) program. It provides both a cross-track mapping view of the earth and an uplooking view from the 12-15 km altitude of the Scaled Composites Proteus aircraft when flown over the ARM sites for IOPs. It has successfully participated in the first two legs of the “grand tour” of the ARM sites (SGP and NSA), resulting in a very good comparison with AIRS observations in 2002 and in an especially interesting data set from the arctic during the Mixed-Phase Cloud Experiment (M-PACE) in 2004.

Digital signal processors for cryogenic high-resolution x-ray detector readout

International Nuclear Information System (INIS)

Friedrich, Stephan; Drury, Owen B.; Bechstein, Sylke; Hennig, Wolfgang; Momayezi, Michael

2003-01-01

We are developing fast digital signal processors (DSPs) to read out superconducting high-resolution X-ray detectors with on-line pulse processing. For superconducting tunnel junction (STJ) detector read-out, the DSPs offer online filtering, rise time discrimination and pile-up rejection. Compared to analog pulse processing, DSP readout somewhat degrades the detector resolution, but improves the spectral purity of the detector response. We discuss DSP performance with our 9-channel STJ array for synchrotron-based high-resolution X-ray spectroscopy. (author)

VO-compliant libraries of high resolution spectra of cool stars

Science.gov (United States)

Montes, D.

2008-10-01

In this contribution we describe a Virtual Observatory (VO) compliant version of the libraries of high resolution spectra of cool stars described by Montes et al. (1997; 1998; and 1999). Since their publication the fully reduced spectra in FITS format have been available via ftp and in the World Wide Web. However, in the VO all the spectra will be accessible using a common web interface following the standards of the International Virtual Observatory Alliance (IVOA). These libraries include F, G, K and M field stars, from dwarfs to giants. The spectral coverage is from 3800 to 10000 Å, with spectral resolution ranging from 0.09 to 3.0 Å.

[Screening and confirmation of 24 hormones in cosmetics by ultra high performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry].

Science.gov (United States)

Li, Zhaoyong; Wang, Fengmei; Niu, Zengyuan; Luo, Xin; Zhang, Gang; Chen, Junhui

2014-05-01

A method of ultra high performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry (UPLC-LTQ/Orbitrap MS) was established to screen and confirm 24 hormones in cosmetics. Various cosmetic samples were extracted with methanol. The extract was loaded onto a Waters ACQUITY UPLC BEH C18 column (50 mm x 2.1 mm, 1.7 microm) using a gradient elution of acetonitrile/water containing 0.1% (v/v) formic acid for the separation. The accurate mass of quasi-molecular ion was acquired by full scanning of electrostatic field orbitrap. The rapid screening was carried out by the accurate mass of quasi-molecular ion. The confirmation analysis for targeted compounds was performed with the retention time and qualitative fragments obtained by data dependent scan mode. Under the optimal conditions, the 24 hormones were routinely detected with mass accuracy error below 3 x 10(-6) (3 ppm), and good linearities were obtained in their respective linear ranges with correlation coefficients higher than 0.99. The LODs (S/N = 3) of the 24 compounds were hormones in 50 cosmetic samples. The results demonstrate that the method is a useful tool for the rapid screening and identification of the hormones in cosmetics.

Impact of the cameras radiometric resolution on the accuracy of determining spectral reflectance coefficients

Science.gov (United States)

Orych, A.; Walczykowski, P.; Jenerowicz, A.; Zdunek, Z.

2014-11-01

Nowadays remote sensing plays a very important role in many different study fields, i.e. environmental studies, hydrology, mineralogy, ecosystem studies, etc. One of the key areas of remote sensing applications is water quality monitoring. Understanding and monitoring of the water quality parameters and detecting different water contaminants is an important issue in water management and protection of whole environment and especially the water ecosystem. There are many remote sensing methods to monitor water quality and detect water pollutants. One of the most widely used method for substance detection with remote sensing techniques is based on usage of spectral reflectance coefficients. They are usually acquired using discrete methods such as spectrometric measurements. These however can be very time consuming, therefore image-based methods are used more and more often. In order to work out the proper methodology of obtaining spectral reflectance coefficients from hyperspectral and multispectral images, it is necessary to verify the impact of cameras radiometric resolution on the accuracy of determination of them. This paper presents laboratory experiments that were conducted using two monochromatic XEVA video sensors (400-1700 nm spectral data registration) with two different radiometric resolutions (12 and 14 bits). In view of determining spectral characteristics from images, the research team used set of interferometric filters. All data collected with multispectral digital video cameras were compared with spectral reflectance coefficients obtained with spectroradiometer. The objective of this research is to find the impact of cameras radiometric resolution on reflectance values in chosen wavelength. The main topic of this study is the analysis of accuracy of spectral coefficients from sensors with different radiometric resolution. By comparing values collected from images acquired with XEVA sensors and with the curves obtained with spectroradiometer it

Multicomponent mixed dopant optimization for rapid screening of polycyclic aromatic hydrocarbons using ultra high performance liquid chromatography coupled to atmospheric pressure photoionization high-resolution mass spectrometry

KAUST Repository

Sioud, Salim

2012-05-04

RATIONALE To enhance the ionization efficiencies in atmospheric pressure photoionization mass spectrometry a dopant with favorable ionization energy such as chlorobenzene is typically used. These dopants are typically toxic and difficult to mix with water-soluble organic solvents. In order to achieve a more efficient and less toxic dopant, a multicomponent mixed dopant was explored. METHODS A multicomponent mixed dopant for non-targeted rapid screening of polycyclic aromatic hydrocarbons (PAHs) was developed and optimized using ultra high performance liquid chromatography (UPLC) coupled to atmospheric pressure photoionization high-resolution mass spectrometry. Various single and multicomponent mixed dopants consisting of ethanol, chlorobenzene, bromobenzene, anisole and toluene were evaluated. RESULTS Fourteen out of eighteen PAHs were successfully separated and detected at low pg/μL levels within 5 min with high mass accuracy ≤4 ppm. The optimal mixed multicomponent dopant consisted of ethanol/chlorobenzene/bromobenzene/anisole (98.975:0.1:0.9:0.025, v/v %) and it improved the limit of detection (LOD) by 2- to 10-fold for the tested PAHs compared to those obtained with pure chlorobenzene. CONCLUSIONS A novel multicomponent dopant that contains 99% ethanol and 1% mixture of chlorobenzene, bromobenzene and anisole was found to be an effective dopant mixture to ionize PAHs. The developed UPLC multicomponent dopant assisted atmospheric pressure photoionization high-resolution mass spectrometry offered a rapid non targeted screening method for detecting the PAHs at low pg/;μL levels within a 5 min run time with high mass accuracy a;circ4 ppm. Copyright © 2012 John Wiley & Sons, Ltd.

Spectrally Resolved and Functional Super-resolution Microscopy via Ultrahigh-Throughput Single-Molecule Spectroscopy.

Science.gov (United States)

Yan, Rui; Moon, Seonah; Kenny, Samuel J; Xu, Ke

2018-03-20

SMLM was next utilized to achieve f-SRM. By encoding functional information into the spectral responses of environment-sensing fluorescent probes, f-SRM transcends the structural information provided by typical SRM techniques and reveals the spatiotemporal distribution of physicochemical parameters with single-molecule sensitivity and nanoscale spatial resolution. As one example, by employing the solvatochromic dye Nile Red to sense local chemical polarity, we revealed nanoscale heterogeneity in the membranes of live mammalian cells. This enabled us to unveil substantial polarity differences between the plasma membrane and the membranes of nanoscale intracellular organelles, a result we determined to be due to differences in local cholesterol levels. With the addition of cholesterol or cholera toxin, we further observed the formation of low-polarity, raftlike nanodomains in the plasma membrane. In another study, we generalized SR-SMLM to fluorogenic single-molecule reactions. As a wide-field technique, SR-SMLM readily captures the emission spectra of individual product fluorescent molecules that are stochastically produced from nonfluorescent reactants at random locations over large sample areas, and therefore, it provides the unique possibility to spectrally identify and characterize single product molecules in a high-throughput fashion. Using the ring-opening reaction of a photochromic spiropyran as an example, we demonstrated that the capability to resolve the emission spectra of single product molecules could unveil rich, multipath reaction pathways. In summary, by integrating the spatial, temporal, and spectral dimensions of single-molecule fluorescence, SR-SMLM and f-SRM add rich spectral and functional dimensions to SRM and thus open up new ways of probing biological and chemical systems at the single-molecule and nanoscale levels.

Comparison of ultra high performance supercritical fluid chromatography, ultra high performance liquid chromatography, and gas chromatography for the separation of synthetic cathinones.

Science.gov (United States)

Carnes, Stephanie; O'Brien, Stacey; Szewczak, Angelica; Tremeau-Cayel, Lauriane; Rowe, Walter F; McCord, Bruce; Lurie, Ira S

2017-09-01

A comparison of ultra high performance supercritical fluid chromatography, ultra high performance liquid chromatography, and gas chromatography for the separation of synthetic cathinones has been conducted. Nine different mixtures of bath salts were analyzed in this study. The three different chromatographic techniques were examined using a general set of controlled synthetic cathinones as well as a variety of other synthetic cathinones that exist as positional isomers. Overall 35 different synthetic cathinones were analyzed. A variety of column types and chromatographic modes were examined for developing each separation. For the ultra high performance supercritical fluid chromatography separations, analyses were performed using a series of Torus and Trefoil columns with either ammonium formate or ammonium hydroxide as additives, and methanol, ethanol or isopropanol organic solvents as modifiers. Ultra high performance liquid chromatographic separations were performed in both reversed phase and hydrophilic interaction chromatographic modes using SPP C18 and SPP HILIC columns. Gas chromatography separations were performed using an Elite-5MS capillary column. The orthogonality of ultra high performance supercritical fluid chromatography, ultra high performance liquid chromatography, and gas chromatography was examined using principal component analysis. For the best overall separation of synthetic cathinones, the use of ultra high performance supercritical fluid chromatography in combination with gas chromatography is recommended. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Distributed Modeling with Parflow using High Resolution LIDAR Data

Science.gov (United States)

Barnes, M.; Welty, C.; Miller, A. J.

2012-12-01

Urban landscapes provide a challenging domain for the application of distributed surface-subsurface hydrologic models. Engineered water infrastructure and altered topography influence surface and subsurface flow paths, yet these effects are difficult to quantify. In this work, a parallel, distributed watershed model (ParFlow) is used to simulate urban watersheds using spatial data at the meter and sub-meter scale. An approach using GRASS GIS (Geographic Resources Analysis Support System) is presented that incorporates these data to construct inputs for the ParFlow simulation. LIDAR topography provides the basis for the fully coupled overland flow simulation. Methods to address real discontinuities in the urban land-surface for use with the grid-based kinematic wave approximation used in ParFlow are presented. The spatial distribution of impervious surface is delineated accurately from high-resolution land cover data; hydrogeological properties are specified from literature values. An application is presented for part of the Dead Run subwatershed of the Gwynns Falls in Baltimore County, MD. The domain is approximately 3 square kilometers, and includes a highly impacted urban stream, a major freeway, and heterogeneous urban development represented at a 10-m horizontal resolution and 1-m vertical resolution. This resolution captures urban features such as building footprints and highways at an appropriate scale. The Dead Run domain provides an effective test case for ParFlow application at the fine scale in an urban environment. Preliminary model runs employ a homogeneous subsurface domain with no-flow boundaries. Initial results reflect the highly articulated topography of the road network and the combined influence of surface runoff from impervious surfaces and subsurface flux toward the channel network. Subsequent model runs will include comparisons of the coupled surface-subsurface response of alternative versions of the Dead Run domain with and without impervious

Signal-to-noise analysis of a birefringent spectral zooming imaging spectrometer

Science.gov (United States)

Li, Jie; Zhang, Xiaotong; Wu, Haiying; Qi, Chun

2018-05-01

Study of signal-to-noise ratio (SNR) of a novel spectral zooming imaging spectrometer (SZIS) based on two identical Wollaston prisms is conducted. According to the theory of radiometry and Fourier transform spectroscopy, we deduce the theoretical equations of SNR of SZIS in spectral domain with consideration of the incident wavelength and the adjustable spectral resolution. An example calculation of SNR of SZIS is performed over 400-1000 nm. The calculation results indicate that SNR with different spectral resolutions of SZIS can be optionally selected by changing the spacing between the two identical Wollaston prisms. This will provide theoretical basis for the design, development and engineering of the developed imaging spectrometer for broad spectrum and SNR requirements.

Performance of a high resolution cavity beam position monitor system

Science.gov (United States)

Walston, Sean; Boogert, Stewart; Chung, Carl; Fitsos, Pete; Frisch, Joe; Gronberg, Jeff; Hayano, Hitoshi; Honda, Yosuke; Kolomensky, Yury; Lyapin, Alexey; Malton, Stephen; May, Justin; McCormick, Douglas; Meller, Robert; Miller, David; Orimoto, Toyoko; Ross, Marc; Slater, Mark; Smith, Steve; Smith, Tonee; Terunuma, Nobuhiro; Thomson, Mark; Urakawa, Junji; Vogel, Vladimir; Ward, David; White, Glen

2007-07-01

It has been estimated that an RF cavity Beam Position Monitor (BPM) could provide a position measurement resolution of less than 1 nm. We have developed a high resolution cavity BPM and associated electronics. A triplet comprised of these BPMs was installed in the extraction line of the Accelerator Test Facility (ATF) at the High Energy Accelerator Research Organization (KEK) for testing with its ultra-low emittance beam. The three BPMs were each rigidly mounted inside an alignment frame on six variable-length struts which could be used to move the BPMs in position and angle. We have developed novel methods for extracting the position and tilt information from the BPM signals including a robust calibration algorithm which is immune to beam jitter. To date, we have demonstrated a position resolution of 15.6 nm and a tilt resolution of 2.1 μrad over a dynamic range of approximately ±20 μm.

High-resolution pyrimidine- and ribose-specific 4D HCCH-COSY spectra of RNA using the filter diagonalization method

International Nuclear Information System (INIS)

Douglas, Justin T.; Latham, Michael P.; Armstrong, Geoffrey S.; Bendiak, Brad; Pardi, Arthur

2008-01-01

The NMR spectra of nucleic acids suffer from severe peak overlap, which complicates resonance assignments. 4D NMR experiments can overcome much of the degeneracy in 2D and 3D spectra; however, the linear increase in acquisition time with each new dimension makes it impractical to acquire high-resolution 4D spectra using standard Fourier transform (FT) techniques. The filter diagonalization method (FDM) is a numerically efficient algorithm that fits the entire multi-dimensional time-domain data to a set of multi-dimensional oscillators. Selective 4D constant-time HCCH-COSY experiments that correlate the H5-C5-C6-H6 base spin systems of pyrimidines or the H1'-C1'-C2'-H2' spin systems of ribose sugars were acquired on the 13 C-labeled iron responsive element (IRE) RNA. FDM-processing of these 4D experiments recorded with only 8 complex points in the indirect dimensions showed superior spectral resolution than FT-processed spectra. Practical aspects of obtaining optimal FDM-processed spectra are discussed. The results here demonstrate that FDM-processing can be used to obtain high-resolution 4D spectra on a medium sized RNA in a fraction of the acquisition time normally required for high-resolution, high-dimensional spectra

Mutual information registration of multi-spectral and multi-resolution images of DigitalGlobe's WorldView-3 imaging satellite

Science.gov (United States)

Miecznik, Grzegorz; Shafer, Jeff; Baugh, William M.; Bader, Brett; Karspeck, Milan; Pacifici, Fabio

2017-05-01

WorldView-3 (WV-3) is a DigitalGlobe commercial, high resolution, push-broom imaging satellite with three instruments: visible and near-infrared VNIR consisting of panchromatic (0.3m nadir GSD) plus multi-spectral (1.2m), short-wave infrared SWIR (3.7m), and multi-spectral CAVIS (30m). Nine VNIR bands, which are on one instrument, are nearly perfectly registered to each other, whereas eight SWIR bands, belonging to the second instrument, are misaligned with respect to VNIR and to each other. Geometric calibration and ortho-rectification results in a VNIR/SWIR alignment which is accurate to approximately 0.75 SWIR pixel at 3.7m GSD, whereas inter-SWIR, band to band registration is 0.3 SWIR pixel. Numerous high resolution, spectral applications, such as object classification and material identification, require more accurate registration, which can be achieved by utilizing image processing algorithms, for example Mutual Information (MI). Although MI-based co-registration algorithms are highly accurate, implementation details for automated processing can be challenging. One particular challenge is how to compute bin widths of intensity histograms, which are fundamental building blocks of MI. We solve this problem by making the bin widths proportional to instrument shot noise. Next, we show how to take advantage of multiple VNIR bands, and improve registration sensitivity to image alignment. To meet this goal, we employ Canonical Correlation Analysis, which maximizes VNIR/SWIR correlation through an optimal linear combination of VNIR bands. Finally we explore how to register images corresponding to different spatial resolutions. We show that MI computed at a low-resolution grid is more sensitive to alignment parameters than MI computed at a high-resolution grid. The proposed modifications allow us to improve VNIR/SWIR registration to better than ¼ of a SWIR pixel, as long as terrain elevation is properly accounted for, and clouds and water are masked out.

Self-triggered image intensifier tube for high-resolution UHECR imaging detector

CERN Document Server

Sasaki, M; Jobashi, M

2003-01-01

The authors have developed a self-triggered image intensifier tube with high-resolution imaging capability. An image detected by a first image intensifier tube as an electrostatic lens with a photocathode diameter of 100 mm is separated by a half-mirror into a path for CCD readout (768x494 pixels) and a fast control to recognize and trigger the image. The proposed system provides both a high signal-to-noise ratio to improve single photoelectron detection and excellent spatial resolution between 207 and 240 mu m rendering this device a potentially essential tool for high-energy physics and astrophysics experiments, as well as high-speed photography. When combined with a 1-arcmin resolution optical system with 50 deg. field-of-view proposed by the present authors, the observation of ultra high-energy cosmic rays and high-energy neutrinos using this device is expected, leading to revolutionary progress in particle astrophysics as a complementary technique to traditional astronomical observations at multiple wave...

Arrested Development: High-Resolution Imaging of Foveal Morphology in Albinism

Science.gov (United States)

McAllister, John T.; Dubis, Adam M.; Tait, Diane M.; Ostler, Shawn; Rha, Jungtae; Stepien, Kimberly E.; Summers, C. Gail; Carroll, Joseph

2010-01-01

Albinism, an inherited disorder of melanin biosynthesis, disrupts normal retinal development, with foveal hypoplasia as one of the more commonly associated ocular phenotypes. However the cellular integrity of the fovea in albinism is not well understood – there likely exist important anatomical differences that underlie phenotypic variability within the disease and that also may affect responsiveness to therapeutic intervention. Here, using spectral domain optical coherence tomography (SD-OCT) and adaptive optics (AO) retinal imaging, we obtained high-resolution images of the foveal region in six individuals with albinism. We provide a quantitative analysis of cone density and outer segment elongation demonstrating that foveal cone specialization is variable in albinism. In addition, our data reveal a continuum of foveal pit morphology, roughly aligning with schematics of normal foveal development based on post-mortem analyses. Different albinism subtypes, genetic mutations, and constitutional pigment background likely play a role in determining the degree of foveal maturation. PMID:20149815

Bayesian Multiresolution Variable Selection for Ultra-High Dimensional Neuroimaging Data.

Science.gov (United States)

Zhao, Yize; Kang, Jian; Long, Qi

2018-01-01

Ultra-high dimensional variable selection has become increasingly important in analysis of neuroimaging data. For example, in the Autism Brain Imaging Data Exchange (ABIDE) study, neuroscientists are interested in identifying important biomarkers for early detection of the autism spectrum disorder (ASD) using high resolution brain images that include hundreds of thousands voxels. However, most existing methods are not feasible for solving this problem due to their extensive computational costs. In this work, we propose a novel multiresolution variable selection procedure under a Bayesian probit regression framework. It recursively uses posterior samples for coarser-scale variable selection to guide the posterior inference on finer-scale variable selection, leading to very efficient Markov chain Monte Carlo (MCMC) algorithms. The proposed algorithms are computationally feasible for ultra-high dimensional data. Also, our model incorporates two levels of structural information into variable selection using Ising priors: the spatial dependence between voxels and the functional connectivity between anatomical brain regions. Applied to the resting state functional magnetic resonance imaging (R-fMRI) data in the ABIDE study, our methods identify voxel-level imaging biomarkers highly predictive of the ASD, which are biologically meaningful and interpretable. Extensive simulations also show that our methods achieve better performance in variable selection compared to existing methods.

Linear and nonlinear optical spectroscopy: Spectral, temporal and spatial resolution

DEFF Research Database (Denmark)

Hvam, Jørn Marcher

1997-01-01

Selected linear and nonlinear optical spectroscopies are being described with special emphasis on the possibility of obtaining simultaneous spectral, temporal and spatial resolution. The potential of various experimental techniques is being demonstrated by specific examples mostly taken from inve...... investigations of the electronic, and opto-electronic, properties of semiconductor nanostructures....

Frequency domain finite-element and spectral-element acoustic wave modeling using absorbing boundaries and perfectly matched layer

Science.gov (United States)

Rahimi Dalkhani, Amin; Javaherian, Abdolrahim; Mahdavi Basir, Hadi

2018-04-01

Wave propagation modeling as a vital tool in seismology can be done via several different numerical methods among them are finite-difference, finite-element, and spectral-element methods (FDM, FEM and SEM). Some advanced applications in seismic exploration benefit the frequency domain modeling. Regarding flexibility in complex geological models and dealing with the free surface boundary condition, we studied the frequency domain acoustic wave equation using FEM and SEM. The results demonstrated that the frequency domain FEM and SEM have a good accuracy and numerical efficiency with the second order interpolation polynomials. Furthermore, we developed the second order Clayton and Engquist absorbing boundary condition (CE-ABC2) and compared it with the perfectly matched layer (PML) for the frequency domain FEM and SEM. In spite of PML method, CE-ABC2 does not add any additional computational cost to the modeling except assembling boundary matrices. As a result, considering CE-ABC2 is more efficient than PML for the frequency domain acoustic wave propagation modeling especially when computational cost is high and high-level absorbing performance is unnecessary.

Radiation budget studies using collocated observations from advanced Very High Resolution Radiometer, High-Resolution Infrared Sounder/2, and Earth Radiation Budget Experiment instruments

Science.gov (United States)

Ackerman, Steven A.; Frey, Richard A.; Smith, William L.

1992-01-01

Collocated observations from the Advanced Very High Resolution Radiometer (AVHRR), High-Resolution Infrared Sounder/2 (HIRS/2), and Earth Radiation Budget Experiment (ERBE) instruments onboard the NOAA 9 satellite are combined to describe the broadband and spectral radiative properties of the earth-atmosphere system. Broadband radiative properties are determined from the ERBE observations, while spectral properties are determined from the HIRS/2 and AVHRR observations. The presence of clouds, their areal coverage, and cloud top pressure are determined from a combination of the HIRS/2 and the AVHRR observations. The CO2 slicing method is applied to the HIRS/2 to determine the presence of upper level clouds and their effective emissivity. The AVHRR data collocated within the HIRS/2 field of view are utilized to determine the uniformity of the scene and retrieve sea surface temperature. Changes in the top of the atmosphere longwave and shortwave radiative energy budgets, and the spectral distribution of longwave radiation are presented as a function of cloud amount and cloud top pressure. The radiative characteristics of clear sky conditions over oceans are presented as a function of sea surface temperature and atmospheric water vapor structure.

Ultra high resolution X-ray detectors

International Nuclear Information System (INIS)

Hess, U.; Buehler, M.; Hentig, R. von; Hertrich, T.; Phelan, K.; Wernicke, D.; Hoehne, J.

2001-01-01

CSP Cryogenic Spectrometers GmbH is developing cryogenic energy dispersive X-ray spectrometers based on superconducting detector technology. Superconducting sensors exhibit at least a 10-fold improvement in energy resolution due to their low energy gap compared to conventional Si(Li) or Ge detectors. These capabilities are extremely valuable for the analysis of light elements and in general for the analysis of the low energy range of the X-ray spectrum. The spectrometer is based on a mechanical cooler needing no liquid coolants and an adiabatic demagnetization refrigerator (ADR) stage which supplies the operating temperature of below 100 mK for the superconducting sensor. Applications include surface analysis in semiconductor industry as well material analysis for material composition e.g. in ceramics or automobile industry

Novel techniques in VUV high-resolution spectroscopy

NARCIS (Netherlands)

Ubachs, W.M.G.; Salumbides, E.J.; Eikema, K.S.E.; de Oliveira, N.; Nahon, L.

2014-01-01

Novel VUV sources and techniques for VUV spectroscopy are reviewed. Laser-based VUV sources have been developed via non-linear upconversion of laser pulses in the nanosecond (ns), the picosecond (ps), and femtosecond (fs) domain, and are applied in high-resolution gas phase spectroscopic studies.

Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution

International Nuclear Information System (INIS)

Chen, Liqing; Wang, Yujun; Wells, David; Toh, Diana; Harold, Hunt; Zhou, Jing; DiGiammarino, Enrico; Meehan, Edward J.

2006-01-01

The crystal structure of the SH3 domain of human osteoclast-stimulating factor has been determined and refined to the ultrahigh resolution of 1.07 Å. The structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors. Osteoclast-stimulating factor (OSF) is an intracellular signaling protein, produced by osteoclasts themselves, that enhances osteoclast formation and bone resorption. It is thought to act via an Src-related signaling pathway and contains SH3 and ankyrin-repeat domains which are involved in protein–protein interactions. As part of a structure-based anti-bone-loss drug-design program, the atomic resolution X-ray structure of the recombinant human OSF SH3 domain (hOSF-SH3) has been determined. The domain, residues 12–72, yielded crystals that diffracted to the ultrahigh resolution of 1.07 Å. The overall structure shows a characteristic SH3 fold consisting of two perpendicular β-sheets that form a β-barrel. Structure-based sequence alignment reveals that the putative proline-rich peptide-binding site of hOSF-SH3 consists of (i) residues that are highly conserved in the SH3-domain family, including residues Tyr21, Phe23, Trp49, Pro62, Asn64 and Tyr65, and (ii) residues that are less conserved and/or even specific to hOSF, including Thr22, Arg26, Thr27, Glu30, Asp46, Thr47, Asn48 and Leu60, which might be key to designing specific inhibitors for hOSF to fight osteoporosis and related bone-loss diseases. There are a total of 13 well defined water molecules forming hydrogen bonds with the above residues in and around the peptide-binding pocket. Some of those water molecules might be important for drug-design approaches. The hOSF-SH3 structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors

High resolution spectroscopy in the microwave and far infrared

Science.gov (United States)

Pickett, Herbert M.

1990-01-01

High resolution rotational spectroscopy has long been central to remote sensing techniques in atmospheric sciences and astronomy. As such, laboratory measurements must supply the required data to make direct interpretation of data for instruments which sense atmospheres using rotational spectra. Spectral measurements in the microwave and far infrared regions are also very powerful tools when combined with infrared measurements for characterizing the rotational structure of vibrational spectra. In the past decade new techniques were developed which have pushed high resolution spectroscopy into the wavelength region between 25 micrometers and 2 mm. Techniques to be described include: (1) harmonic generation of microwave sources, (2) infrared laser difference frequency generation, (3) laser sideband generation, and (4) ultrahigh resolution interferometers.

Ultra-high resolution spectroscopy of the He doubly excited states

International Nuclear Information System (INIS)

Bozek, J.D.; Schlachter, A.S.; Kaindl, G.; Schulz, K.

1995-11-01

Photoionization spectra of the doubly-excited states of He were measured using beamline 9.0.1 at the Advanced Light Source. The beamline utilizes a 4.5 m long 8 cm period undulator as its source together with a spherical grating monochromator to provide an extremely bright source of photons in the range of 20 - 300 eV. A resolving power (E/ΔE) of 64,000 was obtained from the 1 MeV FWEM (2p,3d) doubly excited state resonance of He at 64.12 eV. The high brightness of the source and the very high quality optical elements of the beamline were all essential for achieving such a high resolution. The beamline components and operation are described and spectra of the double excitation resonances of He presented

Ultra wide band antennas

CERN Document Server

Begaud, Xavier

2013-01-01

Ultra Wide Band Technology (UWB) has reached a level of maturity that allows us to offer wireless links with either high or low data rates. These wireless links are frequently associated with a location capability for which ultimate accuracy varies with the inverse of the frequency bandwidth. Using time or frequency domain waveforms, they are currently the subject of international standards facilitating their commercial implementation. Drawing up a complete state of the art, Ultra Wide Band Antennas is aimed at students, engineers and researchers and presents a summary of internationally recog

High Resolution Infrared Radiation Sounder (HIRS) for the Nimbus F Spacecraft

Science.gov (United States)

Koenig, E. W.

1975-01-01

Flown on Nimbus F in June 1975, the high resolution infrared radiation sounder (HIRS) scans with a geographical resolution of 23KM and samples radiance in seventeen selected spectral channels from visible (.7 micron) to far IR (15 micron). Vertical temperature profiles and atmospheric moisture content can be inferred from the output. System operation and test results are described.

Stretchers and compressors for ultra-high power laser systems

Energy Technology Data Exchange (ETDEWEB)

Yakovlev, I V [Institute of Applied Physics, Russian Academy of Sciences, Nizhnii Novgorod (Russian Federation)

2014-05-30

This review is concerned with pulse stretchers and compressors as key components of ultra-high power laser facilities that take advantage of chirped-pulse amplification. The potentialities, characteristics, configurations and methods for the matching and alignment of these devices are examined, with particular attention to the history of the optics of ultra-short, ultra-intense pulses before and after 1985, when the chirped-pulse amplification method was proposed, which drastically changed the view of the feasibility of creating ultra-high power laser sources. The review is intended primarily for young scientists and experts who begin to address the amplification and compression of chirped pulses, experts in laser optics and all who are interested in scientific achievements in the field of ultra-high power laser systems. (review)

Infrared imaging and spectral-domain optical coherence tomography findings correlate with microperimetry in acute macular neuroretinopathy: a case report

Directory of Open Access Journals (Sweden)

Grover Sandeep

2011-10-01

Full Text Available Abstract Introduction Spectral-domain optical coherence tomography findings in a patient with acute macular neuroretinopathy, and correlation with functional defects on microperimetry, are presented. Case presentation A 25-year old Caucasian woman presented with bitemporal field defects following an upper respiratory tract infection. Her visual acuity was 20/20 in both eyes and a dilated fundus examination revealed bilateral hyperpigmentary changes in the papillomacular bundle. Our patient underwent further evaluation with spectral-domain optical coherence tomography, infrared and fundus autofluorescence imaging. Functional changes were assessed by microperimetry. Infrared imaging showed the classic wedge-shaped defects and spectral-domain optical coherence tomography exhibited changes at the inner segment-outer segment junction, with a thickened outer plexiform layer overlying these areas. Fluorescein and indocyanine green angiography did not demonstrate any perfusion defects or any other abnormality. Microperimetry demonstrated focal elevation in threshold correlating with the wedge-shaped defects in both eyes. Conclusion Spectral-domain optical coherence tomography findings provide new evidence of the involvement of the outer plexiform layer of the retina in acute macular neuroretinopathy.

Ribbon scanning confocal for high-speed high-resolution volume imaging of brain.

Directory of Open Access Journals (Sweden)

Alan M Watson

Full Text Available Whole-brain imaging is becoming a fundamental means of experimental insight; however, achieving subcellular resolution imagery in a reasonable time window has not been possible. We describe the first application of multicolor ribbon scanning confocal methods to collect high-resolution volume images of chemically cleared brains. We demonstrate that ribbon scanning collects images over ten times faster than conventional high speed confocal systems but with equivalent spectral and spatial resolution. Further, using this technology, we reconstruct large volumes of mouse brain infected with encephalitic alphaviruses and demonstrate that regions of the brain with abundant viral replication were inaccessible to vascular perfusion. This reveals that the destruction or collapse of large regions of brain micro vasculature may contribute to the severe disease caused by Venezuelan equine encephalitis virus. Visualization of this fundamental impact of infection would not be possible without sampling at subcellular resolution within large brain volumes.

High resolution X-ray spectroscopy of thermal plasmas

International Nuclear Information System (INIS)

Canizares, C.R.

1990-01-01

This paper concentrates on reviewing highlights of the Focal Plane Crystal Spectrometer (FPCS) results on thermal plasmas, particularly supernova remnants (SNRs) and clusters of galaxies from the Einstein observatory. During Einstein's short but happy life, we made over 400 observations with the FPCS of 40 different objects. Three quarters of these were objects in which the emission was primarily from optically thin thermal plasma, primarily supernova remnants (SNRs) and clusters of galaxies. Thermal plasmas provide an excellent illustration of how spectral data, particularly high resolution spectral data, can be an important tool for probing the physical properties of astrophysical objects. (author)

Ultra high field magnetic resonance imaging

International Nuclear Information System (INIS)

Lethimonnier, F.; Vedrine, P.

2007-01-01

Understanding human brain function, brain development and brain dysfunction is one of the great challenges of the twenty first century. Biomedical imaging has now run up against a number of technical constraints that are exposing limits to its potential. In order to overcome the current limits to high-field magnetic resonance cerebral imaging (MRI) and unleash its fullest potential, the Cea has built NeuroSpin, an ultra-high-field neuroimaging facility at its Saclay centre (in the Essonne). NeuroSpin already boasts three fully operational MRI systems. The first is a 3-tesla high-field system and the second is a very-high-field 7-tesla system, both of which are dedicated to clinical studies and investigations in humans, while the third is an ultra-high-field 17.65-tesla system designed for studies on small animals. In 2011, NeuroSpin will be commissioning an 11.7-tesla ultra-high-field system of unprecedented power that is designed for research on human subjects. The level of the magnetic field and the scale required will make this joint French-German project to build the magnet a breakthrough in the international arena. (authors)

A new Time-of-Flight mass measurement project for exotic nuclei and ultra-high precision detector development

Directory of Open Access Journals (Sweden)

Sun Bao-Hua

2016-01-01

Full Text Available The time-of-flight (TOF mass spectrometry (MS, a high-resolution magnetic spectrometer equipped with a fast particle tracking system, is well recognized by its ability in weighing the most exotic nuclei. Currently such TOF-MS can achieve a mass resolution power of about 2×10−4. We show that the mass resolution can be further improved by one order of magnitude with augmented timing and position detectors. We report the progress in developing ultra-fast detectors to be used in TOF-MS.

GOW2.0: A global wave hindcast of high resolution

Science.gov (United States)

Menendez, Melisa; Perez, Jorge; Losada, Inigo

2016-04-01

The information provided by reconstructions of historical wind generated waves is of paramount importance for a variety of coastal and offshore purposes (e.g. risk assessment, design of costal structures and coastal management). Here, a new global wave hindcast (GOW2.0) is presented. This hindcast is an update of GOW1.0 (Reguero et al. 2012) motivated by the emergence of new settings and atmospheric information from reanalysis during recent years. GOW2.0 is based on version 4.18 of WaveWatch III numerical model (Tolman, 2014). Main features of the model set-up are the analysis and selection of recent source terms concerning wave generation and dissipation (Ardhuin et al. 2010, Zieger et al., 2015) and the implementation of obstruction grids to improve the modeling of wave shadowing effects in line with the approach described in Chawla and Tolman (2007). This has been complemented by a multigrid system and the use of the hourly wind and ice coverage from the Climate Forecast System Reanalysis, CFSR (30km spatial resolution approximately). The multigrid scheme consists of a series of "two-way" nested domains covering the whole ocean basins at a 0.5° spatial resolution and continental shelfs worldwide at a 0.25° spatial resolution. In addition, a technique to reconstruct wave 3D spectra for any grid-point is implemented from spectral partitioning information. A validation analysis of GOW2.0 outcomes has been undertaken considering wave spectral information from surface buoy stations and multi-mission satellite data for a spatial validation. GOW2.0 shows a substantial improvement over its predecessor for all the analyzed variables. In summary, GOW2.0 reconstructs historical wave spectral data and climate information from 1979 to present at hourly resolution providing higher spatial resolution over regions where local generated wind seas, bimodal-spectral behaviour and relevant swell transformations across the continental shelf are important. Ardhuin F, Rogers E

Spectral domain optical coherence tomography characteristics in diabetic retinopathy

Directory of Open Access Journals (Sweden)

Laxmi Gella

2014-01-01

Full Text Available Purpose: To report the appearance of diabetic retinopathy lesions using spectral domain optical coherence tomography (SD-OCT. Materials and Methods: A total of 287 eyes of 199 subjects were included. All the subjects underwent complete ophthalmic examination including SD-OCT. Results: The appearance of various lesions of diabetic retinopathy and the retinal layers involved were reported. In subjects with macular edema the prevalence of incomplete PVD was 55.6%. Conclusion: SD-OCT brings new insights into the morphological changes of the retina in diabetic retinopathy.

Studies of high resolution array processing algorithms for multibeam bathymetric applications

Digital Repository Service at National Institute of Oceanography (India)

Chakraborty, B.; Schenke, H.W.

In this paper a study is initiated to observe the usefulness of directional spectral estimation techniques for underwater bathymetric applications. High resolution techniques like the Maximum Likelihood (ML) method and the Maximum Entropy (ME...

Novel strategy for the determination of illegal adulterants in health foods and herbal medicines using high-performance liquid chromatography with high-resolution mass spectrometry.

Science.gov (United States)

Wang, Zhe; Wu, Caisheng; Wang, Gangli; Zhang, Qingsheng; Zhang, Jinlan

2015-03-01

The detection, confirmation, and quantification of multiple illegal adulterants in health foods and herbal medicines by using a single analytical method are a challenge. This paper reports on a new strategy to meet this challenge by employing high-performance liquid chromatography coupled with high-resolution mass spectrometry and a mass spectral tree similarity filter technique. This analytical method can rapidly collect high-resolution, high-accuracy, optionally multistage mass data for compounds in samples. After a preliminary screening by retention time and high-resolution mass spectral data, known illegal adulterants can be detected. The mass spectral tree similarity filter technique has been applied to rapidly confirm these adulterants and simultaneously discover unknown ones. By using full-scan mass spectra as stem and data-dependent subsequent stage mass spectra to form branches, mass spectrometry data from detected compounds are converted into mass spectral trees. The known or unknown illegal adulterants in the samples are confirmed or discovered based on the similarity between their mass spectral trees and those of the references in a library, and they are finally quantified against standard curves. This new strategy has been tested by using 50 samples, and the illegal adulterants were rapidly and effectively detected, confirmed and quantified. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

From spectral holeburning memory to spatial-spectral microwave signal processing

International Nuclear Information System (INIS)

Babbitt, Wm Randall; Barber, Zeb W; Harrington, Calvin; Mohan, R Krishna; Sharpe, Tia; Bekker, Scott H; Chase, Michael D; Merkel, Kristian D; Stiffler, Colton R; Traxinger, Aaron S; Woidtke, Alex J

2014-01-01

Many storage and processing systems based on spectral holeburning have been proposed that access the broad bandwidth and high dynamic range of spatial-spectral materials, but only recently have practical systems been developed that exceed the performance and functional capabilities of electronic devices. This paper reviews the history of the proposed applications of spectral holeburning and spatial-spectral materials, from frequency domain optical memory to microwave photonic signal processing systems. The recent results of a 20 GHz bandwidth high performance spectrum monitoring system with the additional capability of broadband direction finding demonstrates the potential for spatial-spectral systems to be the practical choice for solving demanding signal processing problems in the near future. (paper)