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Sample records for typical piloted ntr

  1. Non Nuclear NTR Environmental Simulator

    International Nuclear Information System (INIS)

    Emrich, William J. Jr.

    2006-01-01

    Nuclear Thermal Rockets or NTR's have been suggested as a propulsion system option for vehicles traveling to the moon or Mars. These engines are capable of providing high thrust at specific impulses at least twice that of today's best chemical engines. The performance constraints on these engines are mainly the result of temperature limitations on the fuel coupled with a limited ability to withstand chemical attack by the hot hydrogen propellant. To operate at maximum efficiency, fuel forms are desired which can withstand the extremely hot, hostile environment characteristic of NTR operation for at least several hours. The simulation of such an environment would require an experimental device which could simultaneously approximate the power, flow, and temperature conditions which a nuclear fuel element (or partial element) would encounter during NTR operation. Such a simulation would allow detailed studies of the fuel behavior and hydrogen flow characteristics under reactor like conditions to be performed. The goal of these simulations would be directed toward expanding the performance envelope of NTR engines over that which was demonstrated during the Rover and NERVA nuclear rocket programs of the 1970's. Current planning calls for such a simulator to be constructed at the Marshall Space Flight Center over the coming year, and it is anticipated that it will be used in the future to evaluate a wide variety of fuel element designs and the materials of which they are constructed. This present work addresses the initial experimental objectives of the NTR simulator with regard to reproducing the fuel degradation patterns previously observed during the NERVA testing

  2. A revolutionary lunar space transportation system architecture using extraterrestrial LOX-augmented NTR propulsion

    Science.gov (United States)

    Borowski, Stanley K.; Corban, Robert R.; Culver, Donald W.; Bulman, Melvin J.; McIlwain, Mel C.

    1994-08-01

    The concept of a liquid oxygen (LOX)-augmented nuclear thermal rocket (NTR) engine is introduced, and its potential for revolutionizing lunar space transportation system (LTS) performance using extraterrestrial 'lunar-derived' liquid oxygen (LUNOX) is outlined. The LOX-augmented NTR (LANTR) represents the marriage of conventional liquid hydrogen (LH2)-cooled NTR and airbreathing engine technologies. The large divergent section of the NTR nozzle functions as an 'afterburner' into which oxygen is injected and supersonically combusted with nuclear preheated hydrogen emerging from the NTR's choked sonic throat: 'scramjet propulsion in reverse.' By varying the oxygen-to-fuel mixture ratio (MR), the LANTR concept can provide variable thrust and specific impulse (Isp) capability with a LH2-cooled NTR operating at relatively constant power output. For example, at a MR = 3, the thrust per engine can be increased by a factor of 2.75 while the Isp decreases by only 30 percent. With this thrust augmentation option, smaller, 'easier to develop' NTR's become more acceptable from a mission performance standpoint (e.g., earth escape gravity losses are reduced and perigee propulsion requirements are eliminated). Hydrogen mass and volume is also reduced resulting in smaller space vehicles. An evolutionary NTR-based lunar architecture requiring only Shuttle C and/or 'in-line' shuttle-derived launch vehicles (SDV's) would operate initially in an 'expandable mode' with NTR lunar transfer vehicles (LTV's) delivering 80 percent more payload on piloted missions than their LOX/LH2 chemical propulsion counterparts. With the establishment of LUNOX production facilities on the lunar surface and 'fuel/oxidizer' depot in low lunar orbit (LLO), monopropellant NTR's would be outfitted with an oxygen propellant module, feed system, and afterburner nozzle for 'bipropellant' operation. The LANTR cislunar LTV now transitions to a reusable mode with smaller vehicle and payload doubling benefits on

  3. Expression, purification, and DNA-binding activity of the solubilized NtrC protein of Herbaspirillum seropedicae.

    Science.gov (United States)

    Twerdochlib, Adriana L; Chubatsu, Leda S; Souza, Emanuel M; Pedrosa, Fábio O; Steffens, M Berenice R; Yates, M Geoffrey; Rigo, Liu U

    2003-07-01

    NtrC is a bacterial enhancer-binding protein (EBP) that activates transcription by the sigma54 RNA polymerase holoenzyme. NtrC has a three domain structure typical of EBP family. In Herbaspirillum seropedicae, an endophytic diazotroph, NtrC regulates several operons involved in nitrogen assimilation, including glnAntrBC. In order to over-express and purify the NtrC protein, DNA fragments containing the complete structural gene for the whole protein, and for the N-terminal+Central and Central+C-terminal domains were cloned into expression vectors. The NtrC and NtrC(N-terminal+Central) proteins were over-expressed as His-tag fusion proteins upon IPTG addition, solubilized using N-lauryl-sarcosyl and purified by metal affinity chromatography. The over-expressed His-tag-NtrC(Central+C-terminal) fusion protein was partially soluble and was also purified by affinity chromatography. DNA band-shift assays showed that the NtrC protein and the Central+C-terminal domains bound specifically to the H. seropedicae glnA promoter region. The C-terminal domain is presumably necessary for DNA-protein interaction and DNA-binding does not require a phosphorylated protein.

  4. Human exploration and settlement of the Moon using LUNOX-augmented NTR propulsion

    Science.gov (United States)

    Borowski, Stanley K.; Culver, Donald W.; Bulman, Melvin J.

    1995-10-01

    An innovative trimodal nuclear thermal rocket (NTR) concept is described which combines conventional liquid hydrogen (LH2)-cooled NTR, Brayton cycle power generation and supersonic combustion ramjet (scramjet) technologies. Known as the liquid oxygen (LOX) augmented NTR (LANTR), this concept utilizes the large divergent section of the NTR nozzle as an 'afterburner' into which LOX is injected and supersonically combusted with nuclear preheated hydrogen emerging from the LANTR's choked sonic throat--'scramjet propulsion in reverse.' By varying the oxygen-to-hydrogen mixture ratio (MR), the LANTR can operate over a wide range of thrust and specific impulse (Isp) values while the reactor core power level remains relatively constant. As the MR varies from zero to seven, the thrust-to-weight ratio for a 15 thousand pound force (klbf) NTR increases by approximately 440%--from 3 to 13--while the Isp decreases by only approximately 45%--from 940 to 515 seconds. This thrust augmentation feature of the LANTR means that 'big engine' performance can be obtained using smaller more affordable, easier to test NTR engines. 'Reoxidizing' the bipropellant LANTR system in low lunar orbit (LLO) with high density 'lunar-derived' LOX (LUNOX) enables a reusable, reduced size and mass lunar transfer vehicle (LTV) which can be deployed and resupplied using two 66 t-class Shuttle-derived launch vehicles. The reusable LANTR can also transport 200 to 300% more payload on each piloted round trip mission than an expendable 'all LH2' NTR system. As initial outposts grow to eventual lunar settlements and LUNOX production capacity increases, the LANTR concept can also enable a rapid 'commuter' shuttle capable of 36 to 24 hour 'one way' trips to the Moon and back with reasonable size vehicles and initial mass in low Earth orbit (IMLEO) requirements.

  5. Nuclear Thermal Rocket (NTR) Development Risk Communication

    Science.gov (United States)

    Kim, Tony

    2014-01-01

    There are clear advantages of development of a Nuclear Thermal Rocket (NTR) for a crewed mission to Mars. NTR for in-space propulsion enables more ambitious space missions by providing high thrust at high specific impulse (approximately 900 sec) that is 2 times the best theoretical performance possible for chemical rockets. Missions can be optimized for maximum payload capability to take more payload with reduced total mass to orbit; saving cost on reduction of the number of launch vehicles needed. Or missions can be optimized to minimize trip time significantly to reduce the deep space radiation exposure to the crew. NTR propulsion technology is a game changer for space exploration. However, "NUCLEAR" is a word that is feared and vilified by some groups and the hostility towards development of any nuclear systems can meet great opposition by the public as well as from national leaders and people in authority. Communication of nuclear safety will be critical to the success of the development of the NTR. Why is there a fear of nuclear? A bomb that can level a city is a scary weapon. The first and only times the Nuclear Bomb was used in a war was on Hiroshima and Nagasaki during World War 2. The "Little Boy" atomic bomb was dropped on Hiroshima on August 6, 1945 and the "Fat Man" on Nagasaki 3 days later on August 9th. Within the first 4 months of bombings, 90- 166 thousand people died in Hiroshima and 60-80 thousand died in Nagasaki. It is important to note for comparison that over 500 thousand people died and 5 million made homeless due to strategic bombing (approximately 150 thousand tons) of Japanese cities and war assets with conventional non-nuclear weapons between 1942- 1945. A major bombing campaign of "firebombing" of Tokyo called "Operation Meetinghouse" on March 9 and 10 consisting of 334 B-29's dropped approximately1,700 tons of bombs around 16 square mile area and over 100 thousand people have been estimated to have died. The declaration of death is very

  6. ''Fast track'' lunar NTR systems assessment for NASA's first lunar outpost and its evolvability to Mars

    International Nuclear Information System (INIS)

    Borowski, S.K.; Alexander, S.W.

    1993-01-01

    Integrated systems and missions studies are presented for an evolutionary lunar-to-Mars space transportion system (STS) based on nuclear thermal rocket (NTR) technology. A ''standardized'' set of engine and stage components are identified and used in a ''building block'' fashion to configure a variety of piloted and cargo, lunar and Mars vehicles. The reference NTR characteristics include a thrust of 50 thousand pounds force (klbf), specific impulse (I sp ) of 900 seconds, and an engine thrust-to-weight ratio of 4.3. For the National Aeronautics and Space Administration's (NASA) First Lunar Outpost (FLO) mission, an expendable NTR stage powered by two such engines can deliver ∼96 metric tonnes (t) to trans-lunar injection (TLI) conditions for an initial mass in low Earth orbit (IMLEO) of ∼198 t compared to 250 t for a cryogenic chemical system. The stage liquid hydrogen (LH 2 ) tank has a diameter, length, and capacity of 10 m, 14.5 m and 66 t, respectively. By extending the stage length and LH 2 capacity to ∼20 m and 96 t, a single launch Mars cargo vehicle could deliver to an elliptical Mars parking orbit a 63 t Mars excursion vehicle (MEV) with a 45 t surface payload. Three 50 klbf engines and the two standardized LH 2 tanks developed for the lunar and Mars cargo vehicles are used to configure the vehicles supporting piloted Mars missions as early as 2010. The ''modular'' NTR vehicle approach forms the basis for an efficient STS able to handle the needs of a wide spectrum of lunar and Mars missions

  7. An Accelerated Development, Reduced Cost Approach to Lunar/Mars Exploration Using a Modular NTR-Based Space Transportation System

    Science.gov (United States)

    Borowski, S.; Clark, J.; Sefcik, R.; Corban, R.; Alexander, S.

    1995-01-01

    The results of integrated systems and mission studies are presented which quantify the benefits and rationale for developing a common, modular lunar/Mars space transportation system (STS) based on nuclear thermal rocket (NTR) technology. At present NASA's Exploration Program Office (ExPO) is considering chemical propulsion for an 'early return to the Moon' and NTR propulsion for the more demanding Mars missions to follow. The time and cost to develop these multiple systems are expected to be significant. The Nuclear Propulsion Office (NPO) has examined a variety of lunar and Mars missions and heavy lift launch vehicle (HLLV) options in an effort to determine a 'standardized' set of engine and stage components capable of satisfying a wide range of Space Exploration Initiative (SEI) missions. By using these components in a 'building block' fashion, a variety of single and multi-engine lunar and Mars vehicles can be configured. For NASA's 'First Lunar Outpost' (FLO) mission, an expendable NTR stage powered by two 50 klbf engines can deliver approximately 96 metric tons (t) to translunar injection (TLI) conditions for an initial mass in low earth orbit (IMLEO) of approximately 198 t compared to 250 t for a cryogenic chemical TLI stage. The NTR stage liquid hydrogen (LH2) tank has a 10 m diameter, 14.5 m length, and 66 t LH2 capacity. The NTR utilizes a UC-ZrC-graphite 'composite' fuel with a specific impulse (Isp) capability of approximately 900 s and an engine thrust-to-weight ratio of approximately 4.3. By extending the size and LH2 capacity of the lunar NTR stage to approximately 20 m and 96 t, respectively, a single launch Mars cargo vehicle capable of delivering approximately 50 t of surface payload is possible. Three 50 klbf NTR engines and the two standardized LH2 tank sizes developed for lunar and Mars cargo vehicle applications would be used to configure the Mars piloted vehicle for a mission as early as 2010. The paper describes the features of the 'common

  8. 'Bimodal' NTR and LANTR propulsion for human missions to Mars/Phobos

    International Nuclear Information System (INIS)

    Borowski, Stanley K.; Dudzinski, Leonard A.; McGuire, Melissa L.

    1999-01-01

    The nuclear thermal rocket (NTR) is one of the leading propulsion options for future human missions to Mars due to its high specific impulse (Isp ∼850-1000 s) and attractive engine thrust-to-weight ratio (∼3-10). Because only a miniscule amount of enriched uranium-235 fuel is consumed in a NTR during the primary propulsion maneuvers of a typical Mars mission, engines configured for both propulsive thrust and modest power generation (referred to as 'bimodal' operation) provide the basis for a robust, 'power-rich' stage enabling propulsive Mars capture and reuse capability. A family of modular 'bimodal' NTR (BNTR) vehicles are described which utilize a common 'core' stage powered by three 66.7 kN (∼15 klbf) BNTRs that produce 50 kWe of total electrical power for crew life support, an active refrigeration/reliquification system for long term, 'zero-boiloff' liquid hydrogen (LH 2 ) storage, and high data rate communications. Compared to other propulsion options, a Mars mission architecture using BNTR transfer vehicles requires fewer transportation system elements which reduces mission mass, cost and risk because of simplified space operations. For difficult Mars options, such as a Phobos rendezvous and sample return mission, volume (not mass) constraints limit the performance of the 'all LH 2 ' BNTR stage. The use of ''LOX-augmented' NTR (LANTR) engines, operating at a modest oxygen-to-hydrogen (O/H) mixture ratio (MR) of 0.5, helps to increase 'bulk' propellant density and total thrust during the trans-Mars injection (TMI) burn. On all subsequent burns, the bimodal LANTR engines operate on LH 2 only (MR=0) to maximize vehicle performance while staying within the mass limits of two ∼80 t 'Magnum' heavy lift launch vehicles (HLLVs)

  9. The NtrY-NtrX two-component system is involved in controlling nitrate assimilation in Herbaspirillum seropedicae strain SmR1.

    Science.gov (United States)

    Bonato, Paloma; Alves, Lysangela R; Osaki, Juliana H; Rigo, Liu U; Pedrosa, Fabio O; Souza, Emanuel M; Zhang, Nan; Schumacher, Jörg; Buck, Martin; Wassem, Roseli; Chubatsu, Leda S

    2016-11-01

    Herbaspirillum seropedicae is a diazotrophic β-Proteobacterium found endophytically associated with gramineae (Poaceae or graminaceous plants) such as rice, sorghum and sugar cane. In this work we show that nitrate-dependent growth in this organism is regulated by the master nitrogen regulatory two-component system NtrB-NtrC, and by NtrY-NtrX, which functions to specifically regulate nitrate metabolism. NtrY is a histidine kinase sensor protein predicted to be associated with the membrane and NtrX is the response regulator partner. The ntrYntrX genes are widely distributed in Proteobacteria. In α-Proteobacteria they are frequently located downstream from ntrBC, whereas in β-Proteobacteria these genes are located downstream from genes encoding an RNA methyltransferase and a proline-rich protein with unknown function. The NtrX protein of α-Proteobacteria has an AAA+ domain, absent in those from β-Proteobacteria. An ntrY mutant of H. seropedicae showed the wild-type nitrogen fixation phenotype, but the nitrate-dependent growth was abolished. Gene fusion assays indicated that NtrY is involved in the expression of genes coding for the assimilatory nitrate reductase as well as the nitrate-responsive two-component system NarX-NarL (narK and narX promoters, respectively). The purified NtrX protein was capable of binding the narK and narX promoters, and the binding site at the narX promoter for the NtrX protein was determined by DNA footprinting. In silico analyses revealed similar sequences in other promoter regions of H. seropedicae that are related to nitrate assimilation, supporting the role of the NtrY-NtrX system in regulating nitrate metabolism in H. seropedicae. © 2016 Federation of European Biochemical Societies.

  10. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.

    Science.gov (United States)

    Mukai, J; Hachiya, T; Shoji-Hoshino, S; Kimura, M T; Nadano, D; Suvanto, P; Hanaoka, T; Li, Y; Irie, S; Greene, L A; Sato, T A

    2000-06-09

    The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell death of neural cells by NGF and other neurotrophins. To elucidate p75NTR-mediated signal transduction, we screened p75NTR-associated proteins by a yeast two-hybrid system. We identified one positive clone and named NADE (p75NTR-associated cell death executor). Mouse NADE has marked homology to the human HGR74 protein. NADE specifically binds to the cell-death domain of p75NTR. Co-expression of NADE and p75NTR induced caspase-2 and caspase-3 activities and the fragmentation of nuclear DNA in 293T cells. However, in the absence of p75NTR, NADE failed to induce apoptosis, suggesting that NADE expression is necessary but insufficient for p75NTR-mediated apoptosis. Furthermore, p75NTR/NADE-induced cell death was dependent on NGF but not BDNF, NT-3, or NT-4/5, and the recruitment of NADE to p75NTR (intracellular domain) was dose-dependent. We obtained similar results from PC12 cells, nnr5 cells, and oligodendrocytes. Taken together, NADE is the first signaling adaptor molecule identified in the involvement of p75NTR-mediated apoptosis induced by NGF, and it may play an important role in the pathogenesis of neurogenetic diseases.

  11. The ntrB and ntrC Genes Are Involved in the Regulation of Poly-3-Hydroxybutyrate Biosynthesis by Ammonia in Azospirillum brasilense Sp7

    Science.gov (United States)

    Sun, Jun; Peng, Xuan; Van Impe, Jan; Vanderleyden, Jos

    2000-01-01

    Azospirillum brasilense Sp7 and its ntrA (rpoN), ntrBC, and ntrC mutants have been evaluated for their capabilities of poly-3-hydroxybutyrate (PHB) accumulation in media with high and low ammonia concentrations. It was observed that the ntrBC and ntrC mutants can produce PHB in both low- and high-C/N-ratio media, while no significant PHB production was observed for the wild type or the ntrA mutant in low-C/N-ratio media. Further investigation by fermentation analysis indicated that the ntrBC and ntrC mutants were able to grow and accumulate PHB simultaneously in the presence of a high concentration of ammonia in the medium, while little PHB was produced in the wild type and ntrA (rpoN) mutant during active growth phase. These results provide the first genetic evidence that the ntrB and ntrC genes are involved in the regulation of PHB synthesis by ammonia in A. brasilense Sp7. PMID:10618211

  12. Human Exploration Mission Capabilities to the Moon, Mars, and Near Earth Asteroids Using ''Bimodal'' NTR Propulsion

    International Nuclear Information System (INIS)

    Stanley K. Borowski; Leonard A. Dudzinski; Melissa L. McGuire

    2000-01-01

    The nuclear thermal rocket (NTR) is one of the leading propulsion options for future human exploration missions because of its high specific impulse (Isp ∼ 850 to 1000 s) and attractive engine thrust-to-weight ratio (∼ 3 to 10). Because only a minuscule amount of enriched 235 U fuel is consumed in an NRT during the primary propulsion maneuvers of a typical Mars mission, engines configured both for propulsive thrust and modest power generation (referred to as 'bimodal' operation) provide the basis for a robust, power-rich stage with efficient propulsive capture capability at the moon and near-earth asteroids (NEAs), where aerobraking cannot be utilized. A family of modular bimodal NTR (BNTR) space transfer vehicles utilize a common core stage powered by three ∼15-klb f engines that produce 50 kW(electric) of total electrical power for crew life support, high data rate communications with Earth, and an active refrigeration system for long-term, zero-boiloff liquid hydrogen (LH 2 ) storage. This paper describes details of BNTR engines and designs of vehicles using them for various missions

  13. The transcriptional activator NtrC controls the expression and activity of glutamine synthetase in Herbaspirillum seropedicae.

    Science.gov (United States)

    Persuhn, D C; Souza, E M; Steffens, M B; Pedrosa, F O; Yates, M G; Rigo, L U

    2000-11-15

    The role of the Ntr system in Herbaspirillum seropedicae was determined via ntrB and ntrC mutants. Three phenotypes were identified in these mutants: Nif(-), deficiency in growth using nitrate, and low glutamine synthetase (GS) activity. All phenotypes were restored by the plasmid pKRT1 containing the intact glnA, ntrB and ntrC genes of H. seropedicae. The promoter region of glnA was subcloned into a beta-galactosidase fusion vector and the results suggested that NtrC positively regulates the glnA promoter in response to low nitrogen. The H. seropedicae ntrC and ntrB mutant strains showed a deficiency of adenylylation/deadenylylation of GS, indicating that NtrC and NtrB are involved in both transcription and activity control of GS in this organism.

  14. Comparing oxytocin and cortisol regulation in a double-blind, placebo-controlled, hydrocortisone challenge pilot study in children with autism and typical development.

    Science.gov (United States)

    Corbett, Blythe A; Bales, Karen L; Swain, Deanna; Sanders, Kevin; Weinstein, Tamara A R; Muglia, Louis J

    2016-01-01

    Children with autism spectrum disorder (ASD) show marked impairment in social functioning and poor adaptation to new and changing contexts, which may be influenced by underlying regulatory processes. Oxytocin (OT) and cortisol are key neuromodulators of biological and behavioral responses, show a synergistic effect, and have been implicated in the neuropathological profile in ASD. However, they are rarely investigated together. The purpose of the pilot study was to evaluate the relationship between cortisol and OT in children with ASD under baseline and physiological stress (hydrocortisone challenge) conditions. Arginine vasopressin (AVP), structurally similar to OT, was also examined. A double-blind, placebo-controlled, randomly assigned, crossover design was employed in 25 children 8-to-12 years with ASD (N = 14) or typical development (TD, N = 11). A low dose of hydrocortisone and placebo were administered via liquid suspension. Analysis of variance (ANOVA) was used to examine the within-subject factor "Condition" (hydrocortisone/placebo) and "Time" (pre and post) and the between-subject factor "Group" (ASD vs. TD). Pearson correlations examined the relationship between hormone levels and clinical profile. There was a significant Time × Condition × Group interaction F (1.23) = 4.18, p = 0.05 showing a rise in OT during the experimental condition (hydrocortisone) and a drop during the placebo condition for the TD group but not the ASD group. There were no group differences for AVP. Hormone levels were associated with social profiles. For the TD group, an inverse relationship was observed. OT increased during physiological challenge suggesting that OT played a stress-buffering role during cortisol administration. In contrast for the ASD group, OT remained unchanged or decreased during both the physiological challenge and the placebo condition, suggesting that OT failed to serve as a stress buffer under conditions of physiological stress. While

  15. Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

    Science.gov (United States)

    Brito, Verónica; Giralt, Albert; Enriquez-Barreto, Lilian; Puigdellívol, Mar; Suelves, Nuria; Zamora-Moratalla, Alfonsa; Ballesteros, Jesús J.; Martín, Eduardo D.; Dominguez-Iturza, Nuria; Morales, Miguel; Alberch, Jordi; Ginés, Sílvia

    2014-01-01

    Learning and memory deficits are early clinical manifestations of Huntington’s disease (HD). These cognitive impairments have been mainly associated with frontostriatal HD pathology; however, compelling evidence provided by several HD murine models suggests that the hippocampus may contribute to synaptic deficits and memory dysfunction in HD. The neurotrophin receptor p75NTR negatively regulates spine density, which is associated with learning and memory; therefore, we explored whether disturbed p75NTR function in the hippocampus could contribute to synaptic dysfunction and memory deficits in HD. Here, we determined that levels of p75NTR are markedly increased in the hippocampus of 2 distinct mouse models of HD and in HD patients. Normalization of p75NTR levels in HD mutant mice heterozygous for p75NTR prevented memory and synaptic plasticity deficits and ameliorated dendritic spine abnormalities, likely through normalization of the activity of the GTPase RhoA. Moreover, viral-mediated overexpression of p75NTR in the hippocampus of WT mice reproduced HD learning and memory deficits, while knockdown of p75NTR in the hippocampus of HD mice prevented cognitive decline. Together, these findings provide evidence of hippocampus-associated memory deficits in HD and demonstrate that p75NTR mediates synaptic, learning, and memory dysfunction in HD. PMID:25180603

  16. NtrC-dependent control of exopolysaccharide synthesis and motility in Burkholderia cenocepacia H111.

    Directory of Open Access Journals (Sweden)

    Yilei Liu

    Full Text Available Burkholderia cenocepacia is a versatile opportunistic pathogen that survives in a wide variety of environments, which can be limited in nutrients such as nitrogen. We have previously shown that the sigma factor σ54 is involved in the control of nitrogen assimilation and virulence in B. cenocepacia H111. In this work, we investigated the role of the σ54 enhancer binding protein NtrC in response to nitrogen limitation and in the pathogenicity of H111. Of 95 alternative nitrogen sources tested the ntrC showed defects in the utilisation of nitrate, urea, L-citrulline, acetamide, DL-lactamide, allantoin and parabanic acid. RNA-Seq and phenotypic analyses of an ntrC mutant strain showed that NtrC positively regulates two important phenotypic traits: exopolysaccharide (EPS production and motility. However, the ntrC mutant was not attenuated in C. elegans virulence.

  17. Typical entanglement

    Science.gov (United States)

    Deelan Cunden, Fabio; Facchi, Paolo; Florio, Giuseppe; Pascazio, Saverio

    2013-05-01

    Let a pure state | ψ> be chosen randomly in an NM-dimensional Hilbert space, and consider the reduced density matrix ρ A of an N-dimensional subsystem. The bipartite entanglement properties of | ψ> are encoded in the spectrum of ρ A . By means of a saddle point method and using a "Coulomb gas" model for the eigenvalues, we obtain the typical spectrum of reduced density matrices. We consider the cases of an unbiased ensemble of pure states and of a fixed value of the purity. We finally obtain the eigenvalue distribution by using a statistical mechanics approach based on the introduction of a partition function.

  18. Self-renewal and chemotherapy resistance of p75NTR positive cells in esophageal squamous cell carcinomas

    International Nuclear Information System (INIS)

    Huang, Sheng-Dong; Yuan, Yang; Liu, Xiao-Hong; Gong, De-Jun; Bai, Chen-Guang; Wang, Feng; Luo, Jun-Hui; Xu, Zhi-Yun

    2009-01-01

    p75 NTR has been used to isolate esophageal and corneal epithelial stem cells. In the present study, we investigated the expression of p75 NTR in esophageal squamous cell carcinoma (ESCC) and explored the biological properties of p75 NTR+ cells. p75 NTR expression in ESCC was assessed by immunohistochemistry. p75 NTR+ and p75 NTR- cells of 4 ESCC cell lines were separated by fluorescence-activated cell sorting. Differentially expressed genes between p75 NTR+ and p75 NTR- cells were determined by real-time quantitative reverse transcription-PCR. Sphere formation assay, DDP sensitivity assay, 64 copper accumulation assay and tumorigenicity analysis were performed to determine the capacity of self-renewal, chemotherapy resistance and tumorigenicity of p75 NTR+ cells. In ESCC specimens, p75 NTR was found mainly confined to immature cells and absent in cells undergoing terminal differentiation. The percentage of p75 NTR+ cells was 1.6%–3.7% in Eca109 and 3 newly established ESCC cell lines. The expression of Bmi-1, which is associated with self-renewal of stem cells, was significantly higher in p75 NTR+ cells. p63, a marker identified in keratinocyte stem cells, was confined mainly to p75 NTR+ cells. The expression of CTR1, which is associated with cisplatin (DDP)-resistance, was significantly decreased in p75 NTR+ cells. Expression levels of differentiation markers, such as involucrin, cytokeratin 13, β1-integrin and β4-integrin, were lower in p75 NTR+ cells. In addition, p75 NTR+ cells generated both p75 NTR+ and p75 NTR- cells, and formed nonadherent spherical clusters in serum-free medium supplemented with growth factors. Furthermore, p75 NTR+ cells were found to be more resistant to DDP and exhibited lower 64 copper accumulation than p75 NTR- cells. Our results demonstrated that p75 NTR+ cells possess some characteristics of CSCs, namely, self-renewal and chemotherapy resistance. Chemotherapy resistance of p75 NTR+ cells may probably be attributable to

  19. Induction of the p75NTR by Aryl Propionic Acids in Prostate Cancer Cells

    National Research Council Canada - National Science Library

    Quann, Emily

    2007-01-01

    .... I have found that treatment of prostate cancer cells with the aryl propionic acids R-flurbiprofen and ibuprofen induces reexpression of p75NTR, decreases cell survival, and increases apoptosis...

  20. Contribution of p75NTR to Schwannoma Growth and Therapeutic Responses

    Science.gov (United States)

    2017-05-01

    reducing schwannoma cell growth in culture and in animal models of human schwannoma disease. We find that the NF2 gene product, merlin, regulates p75NTR...treatment period. B. Waterfall plots of change in tumor volume for each tumor. Task 6- Define the ability of simultaneous inhibition of p75NTR and mTOR...mTOR inhibitors in culture, we have not used these compounds in animal models . Changes that had a significant impact on expenditures- None

  1. Reduced anxiety-like behavior and altered hippocampal morphology in female p75NTR exon IV-/- mice.

    Directory of Open Access Journals (Sweden)

    Zoe ePuschban

    2016-06-01

    Full Text Available The presence of the neurotrophin receptor p75NTR in adult basal forebrain cholinergic neurons, precursor cells in the subventricular cell layer and the subgranular cell layer of the hippocampus has been linked to alterations in learning as well as anxiety- and depression- related behaviors. In contrast to previous studies performed in a p75NTR exonIII-/- model still expressing the short isoform of the p75NTR, we focused on locomotor and anxiety–associated behavior in p75NTR exonIV-/- mice lacking both p75NTR isoforms. Comparing p75NTR exonIV-/- and wildtype mice for both male and female animals showed an anxiolytic-like behavior as evidenced by increased central activities in the open field paradigm and flex field activity system as well as higher numbers of open arm entries in the elevated plus maze test in female p75NTR knockout mice.Morphometrical analyses of dorsal and ventral hippocampus revealed a reduction of width of the dentate gyrus and the granular cell layer in the dorsal but not ventral hippocampus in male and female p75NTR exonIV -/- mice. We conclude that germ-line deletion of p75NTR seems to differentially affect morphometry of dorsal and ventral dentate gyrus and that p75NTR may play a role in anxiety-like behavior, specifically in female mice.

  2. Typical signature of DNA damage in white blood cells: a pilot study on etheno adducts in Danish mother-newborn child pairs

    DEFF Research Database (Denmark)

    Arab, K; Pedersen, Marie; Nair, J

    2009-01-01

    The impact of DNA damage commonly thought to be involved in chronic degenerative disease causation is particularly detrimental during fetal development. Within a multicenter study, we analyzed 77 white blood cell (WBC) samples from mother-newborn child pairs to see if imprinting of DNA damage...... in mother and newborn shows a similar pattern. Two adducts 1,N(6)-ethenodeoxyadenosine (epsilondA) and 3,N(4)-ethenodeoxycytidine (epsilondC) were measured by our ultrasensitive immunoaffinity (32)P-post-labeling method. These miscoding etheno-DNA adducts are generated by the reaction of lipid peroxidation...... arising from endogenous reactive aldehydes in WBC of both mother and newborn can be reliably assessed by epsilondA and epsilondC as biomarkers. The high correlation of etheno adduct levels in mother and child WBC suggests that a typical signature of DNA damage is induced similarly in fetus and mother...

  3. The impact of eating behavior on psychological symptoms typical of reactive hypoglycemia. A pilot study comparing women with polycystic ovary syndrome to controls.

    Science.gov (United States)

    Barry, John A; Bouloux, Pierre; Hardiman, Paul J

    2011-08-01

    The idea that diet can affect mood and behavior in women with polycystic ovary syndrome (PCOS) by altering blood glucose levels has become popular in recent years. This paper describes an online survey (N=462) of 24 women with PCOS, 299 healthy control women, 47 women who possibly had undiagnosed PCOS, and 92 men. The groups were compared for symptoms of mood and behavioral symptoms typical of reactive (postprandial) hypoglycemia. The outcome measures were two questionnaires that measure states associated with hypoglycemia: the Hypoglycemia Symptom Checklist-7 (HSC-7), which measures behavioral symptoms and the Mood Adjective Checklist (MACL), which measures emotional states. Controlling for age and body mass index (BMI) using between-groups analysis of covariance (ANCOVA), the women with PCOS scored significantly higher than the other three groups (pPCOS compared to twelve healthy control women closely matched for age, BMI, and eating behavior. The findings are suggestive of hypoglycemia-related mood and behavioral problems in PCOS. Future research should test whether blood glucose levels correlate with these symptoms in PCOS, and whether a low glycemic index ('low-GI') diet improves the symptoms. Copyright © 2011 Elsevier Ltd. All rights reserved.

  4. A pilot play-based intervention to improve the social play interactions of children with autism spectrum disorder and their typically developing playmates.

    Science.gov (United States)

    Henning, Belindi; Cordier, Reinie; Wilkes-Gillan, Sarah; Falkmer, Torbjorn

    2016-08-01

    Occupational therapists play a key role in addressing the social difficulties of children with ASD. However, interventions are often time intensive, without outcomes generalising beyond the clinic setting. To examine the feasibility and preliminary effectiveness of an intervention to address the social play skills of children with ASD. Participants in this multiple case study design were five children with autism spectrum disorder (ASD), five typically developing playmates and five parents of children with ASD. Two therapists and parents delivered the intervention involving clinic play sessions and home modules. Parents' treatment adherence was recorded. The Test of Playfulness was scored by a blinded rater to examine child outcomes following the intervention. Line graphs were used to examine case data. Percentage of non-overlapping data (PND) was used to calculate the single-case effect size for each child. Parents completed 92.2% of the intervention. Children's case data showed an upwards trend from pre- to post-intervention in four of the five pairs (child with ASD and playmate). However, there was a decrease in scores from post-intervention to the two-month home follow-up for all but one pair. PND indicated the intervention was effective for two children with ASD and three of their playmates, had a questionable effect on three children with ASD and no observable effect on two playmates. The intervention demonstrated preliminary feasibility and effectiveness for improving the social play skills of some children with ASD. Careful consideration is needed to identify which children with ASD and which playmates would be best suited for this intervention approach. © 2016 Occupational Therapy Australia.

  5. Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells

    Directory of Open Access Journals (Sweden)

    Joanna Bandoła

    2017-08-01

    Full Text Available Plasmacytoid dendritic cells (pDCs regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the effector immune cells involved. We report, for the first time, the expression and immune-regulatory function of the low affinity neurotrophin receptor p75 neurotrophin receptor (p75NTR by the antigen-presenting pDCs, mediated by toll-like receptor (TLR 9 activation and differential phosphorylation of interferon regulatory factor 3 and 7. The modulation of p75NTR on pDCs significantly influences disease progression of asthma in an ovalbumin-induced mouse model mediated by the TLR9 signaling pathway. p75NTR activation of pDCs from patients with asthma increased allergen-specific T cell proliferation and cytokine secretion in nerve growth factor concentration-dependent manner. Further, p75NTR activation of pDCs delayed the onset of autoimmune diabetes in RIP-CD80GP mice and aggravated graft-versus-host disease in a xenotransplantation model. Thus, p75NTR signaling on pDCs constitutes a new and critical mechanism connecting neurotrophin signaling and immune response regulation with great therapeutic potential for a variety of immune disorders.

  6. Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells.

    Science.gov (United States)

    Bandoła, Joanna; Richter, Cornelia; Ryser, Martin; Jamal, Arshad; Ashton, Michelle P; von Bonin, Malte; Kuhn, Matthias; Dorschner, Benjamin; Alexopoulou, Dimitra; Navratiel, Katrin; Roeder, Ingo; Dahl, Andreas; Hedrich, Christian M; Bonifacio, Ezio; Brenner, Sebastian; Thieme, Sebastian

    2017-01-01

    Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the effector immune cells involved. We report, for the first time, the expression and immune-regulatory function of the low affinity neurotrophin receptor p75 neurotrophin receptor (p75NTR) by the antigen-presenting pDCs, mediated by toll-like receptor (TLR) 9 activation and differential phosphorylation of interferon regulatory factor 3 and 7. The modulation of p75NTR on pDCs significantly influences disease progression of asthma in an ovalbumin-induced mouse model mediated by the TLR9 signaling pathway. p75NTR activation of pDCs from patients with asthma increased allergen-specific T cell proliferation and cytokine secretion in nerve growth factor concentration-dependent manner. Further, p75NTR activation of pDCs delayed the onset of autoimmune diabetes in RIP-CD80GP mice and aggravated graft-versus-host disease in a xenotransplantation model. Thus, p75NTR signaling on pDCs constitutes a new and critical mechanism connecting neurotrophin signaling and immune response regulation with great therapeutic potential for a variety of immune disorders.

  7. The p75NTR tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells

    International Nuclear Information System (INIS)

    Khwaja, Fatima; Tabassum, Arshia; Allen, Jeff; Djakiew, Daniel

    2006-01-01

    The p75 neurotrophin receptor (p75 NTR ) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. This study shows that p75 NTR retarded cell cycle progression by induced accumulation of cells in G0/G1 and a reduction in the S phase of the cell cycle. The rescue of tumor cells from cell cycle progression by a death domain deleted (ΔDD) dominant-negative antagonist of p75 NTR showed that the death domain transduced anti-proliferative activity in a ligand-independent manner. Conversely, addition of NGF ligand rescued retardation of cell cycle progression with commensurate changes in components of the cyclin/cdk holoenzyme complex. In the absence of ligand, p75 NTR -dependent cell cycle arrest facilitated an increase in apoptotic nuclear fragmentation of the prostate cancer cells. Apoptosis of p75 NTR expressing cells occurred via the intrinsic mitochondrial pathway leading to a sequential caspase-9 and -7 cascade. Since the death domain deleted dominant-negative antagonist of p75 NTR rescued intrinsic caspase associated apoptosis in PC-3 cells, this shows p75 NTR was integral to ligand independent induction of apoptosis. Moreover, the ability of ligand to ameliorate the p75 NTR -dependent intrinsic apoptotic cascade indicates that NGF functioned as a survival factor for p75 NTR expressing prostate cancer cells

  8. The p75{sup NTR} tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells

    Energy Technology Data Exchange (ETDEWEB)

    Khwaja, Fatima [Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057-1436 (United States); Tabassum, Arshia [Toronto Western Hospital, Toronto, ON, M5T258 (Canada); Allen, Jeff [National Center for Complementary and Alternative Medicine, N.I.H., Bethesda, MD 20892 (United States); Djakiew, Daniel [Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057-1436 (United States) and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057-1436 (United States)

    2006-03-24

    The p75 neurotrophin receptor (p75{sup NTR}) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. This study shows that p75{sup NTR} retarded cell cycle progression by induced accumulation of cells in G0/G1 and a reduction in the S phase of the cell cycle. The rescue of tumor cells from cell cycle progression by a death domain deleted ({delta}DD) dominant-negative antagonist of p75{sup NTR} showed that the death domain transduced anti-proliferative activity in a ligand-independent manner. Conversely, addition of NGF ligand rescued retardation of cell cycle progression with commensurate changes in components of the cyclin/cdk holoenzyme complex. In the absence of ligand, p75{sup NTR}-dependent cell cycle arrest facilitated an increase in apoptotic nuclear fragmentation of the prostate cancer cells. Apoptosis of p75{sup NTR} expressing cells occurred via the intrinsic mitochondrial pathway leading to a sequential caspase-9 and -7 cascade. Since the death domain deleted dominant-negative antagonist of p75{sup NTR} rescued intrinsic caspase associated apoptosis in PC-3 cells, this shows p75{sup NTR} was integral to ligand independent induction of apoptosis. Moreover, the ability of ligand to ameliorate the p75{sup NTR}-dependent intrinsic apoptotic cascade indicates that NGF functioned as a survival factor for p75{sup NTR} expressing prostate cancer cells.

  9. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat.

    Science.gov (United States)

    Park, J A; Lee, J Y; Sato, T A; Koh, J Y

    2000-12-15

    Recently, a 22 kDa protein termed p75(NTR)-associated death executor (NADE) was discovered to be a necessary factor for p75(NTR)-mediated apoptosis in certain cells. However, the possible role for p75(NTR)/NADE in pathological neuronal death has yet been undetermined. In the present study, we have examined this possibility in vivo and in vitro. Exposure of cortical cultures to zinc induced both p75(NTR) and NADE in neurons, whereas exposure to NMDA, ionomycin, iron, or H(2)O(2) induced neither. In addition, zinc exposure increased neuronal NGF expression and its release into the medium. A function-blocking antibody of p75(NTR) (REX) inhibited association between p75(NTR) and NADE as well as neuronal death induced by zinc. Conversely, NGF augmented zinc-induced neuronal death. Caspase inhibitors reduced zinc-induced neuronal death, indicating that caspases were involved. Because reduction of NADE expression with cycloheximide or NADE antisense oligonucleotides attenuated zinc-induced neuronal death, NADE appears to contribute to p75(NTR)-induced cortical neuronal death as shown in other cells. Because zinc neurotoxicity may be a key mechanism of neuronal death after transient forebrain ischemia, we next examined this model. After ischemia, p75(NTR) and NADE were induced in degenerating rat hippocampal CA1 neurons. There was a close correlation between zinc accumulation and p75(NTR)/NADE induction. Suggesting the role of zinc here, injection of a metal chelator, CaEDTA, into the lateral ventricle completely blocked the induction of p75(NTR) and NADE. Our results suggest that co-induction of p75(NTR) and NADE plays a role in zinc-triggered neuronal death in vitro and in vivo.

  10. Carprofen Induction of p75NTR Dependent Apoptosis via the p38 MAPK Pathway in Prostate Cancer Cells

    Science.gov (United States)

    Khwaja, Fatima S.; Quann, Emily J.; Pattabiraman, Nagarajan; Wynne, Shehla; Djakiew, Daniel

    2008-01-01

    The p75NTR functions as a tumor suppressor in prostate epithelial cells, where its expression declines with progression to malignant cancer. Previously, we demonstrated that treatment with R-flurbiprofen or ibuprofen induced p75NTR expression in several prostate cancer cell lines leading to p75NTR mediated decreased survival. Utilizing the 2-phenyl propionic acid moiety of these profens as a pharmacophore, we screened an in silico data base of 30 million compounds and identified carprofen as having an order of magnitude greater activity for induction of p75NTR levels and inhibition of cell survival. Prostate (PC-3, DU-145) and bladder (T24) cancer cells were more sensitive to carprofen induction of p75NTR associated loss of survival than breast (MCF7) and fibroblast (3T3) cells. Transfection of prostate cell lines with a dominant negative form of p75NTR prior to carprofen treatment partially rescued cell survival demonstrating a cause and effect relationship between carprofen induction of p75NTR levels and inhibition of survival. Carprofen induced apoptotic nuclear fragmentation in prostate but not in MCF7 and 3T3 cells. Furthermore, siRNA knockdown of the p38 MAPK protein prevented induction of p75NTR by carprofen in both prostate cell lines. Carprofen treatment induced phosphorylation of p38 MAPK as early as within 1 minute. Expression of a dominant negative form of MK2, the kinase downstream of p38 MAPK frequently associated with signaling cascades leading to apoptosis, prevented carprofen induction of the p75NTR protein. Collectively, we identify carprofen as a highly potent profen capable of inducing p75NTR dependent apoptosis via the p38 MAPK pathway in prostate cancer cells. PMID:18974393

  11. Characterization of NGF, trkANGFR, and p75NTR in Retina of Mice Lacking Reelin Glycoprotein

    Directory of Open Access Journals (Sweden)

    Bijorn Omar Balzamino

    2014-01-01

    Full Text Available Both Reelin and Nerve Growth Factor (NGF exert crucial roles in retinal development. Retinogenesis is severely impaired in E-reeler mice, a model of Reelin deficiency showing specific Green Fluorescent Protein expression in Rod Bipolar Cells (RBCs. Since no data are available on Reelin and NGF cross-talk, NGF and trkANGFR/ p75NTR expression was investigated in retinas from E-reeler versus control mice, by confocal microscopy, Western blotting, and real time PCR analysis. A scattered increase of NGF protein was observed in the Ganglion Cell Layer and more pronounced in the Inner Nuclear Layer (INL. A selective increase of p75NTR was detected in most of RBCs and in other cell subtypes of INL. On the contrary, a slight trend towards a decrease was detected for trkANGFR, albeit not significant. Confocal data were validated by Western blot and real time PCR. Finally, the decreased trkANGFR/ p75NTR ratio, representative of p75NTR increase, significantly correlated with E-reeler versus E-control. These data indicate that NGF-trkANGFR/ p75NTR is affected in E-reeler retina and that p75NTR might represent the main NGF receptor involved in the process. This first NGF-trkANGFR/ p75NTR characterization suggests that E-reeler might be suitable for exploring Reelin-NGF cross-talk, representing an additional information source in those pathologies characterized by retinal degeneration.

  12. Final Report - Assessment of Testing Options for the NTR at the INL

    Energy Technology Data Exchange (ETDEWEB)

    Howe, Steven D; McLing, Travis L; McCurry, Michael; Plummer, Mitchell A

    2013-02-01

    One of the main technologies that can be developed to dramatically enhance the human exploration of space is the nuclear thermal rocket (NTR). Several studies over the past thirty years have shown that the NTR can reduce the cost of a lunar outpost, reduce the risk of a human mission to Mars, enable fast transits for most missions throughout the solar system, and reduce the cost and time for robotic probes to deep space. Three separate committees of the National Research Council of the National Academy of Sciences have recommended that NASA develop the NTR. One of the primary issues in development of the NTR is the ability to verify a flight ready unit. Three main methods can be used to validate safe operation of a NTR: 1) Full power, full duration test in an above ground facility that scrubs the rocket exhaust clean of any fission products; 2) Full power , full duration test using the Subsurface Active Filtering of Exhaust (SAFE) technique to capture the exhaust in subsurface strata; 3) Test of the reactor fuel at temperature and power density in a driver reactor with subsequent first test of the fully integrated NTR in space. The first method, the above ground facility, has been studied in the past. The second method, SAFE, has been examined for application at the Nevada Test Site. The third method relies on the fact that the Nuclear Furnace series of tests in 1971 showed that the radioactive exhaust coming from graphite based fuel for the NTR could be completely scrubbed of fission products and the clean hydrogen flared into the atmosphere. Under funding from the MSFC, the Center for Space Nuclear Research (CSNR) at the Idaho National laboratory (INL) has completed a reexamination of Methods 2 and 3 for implementation at the INL site. In short, the effort performed the following: 1) Assess the geology of the INL site and determine a location suitable SAFE testing; 2) Perform calculations of gas transport throughout the geology; 3) Produce a cost estimate of a

  13. NTR-Enhanced Lunar-Base Supply using Existing Launch Fleet Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess; Emily Colvin; Paul G. Cummings

    2009-06-01

    During the summer of 2006, students at the Center for Space Nuclear Research sought to augment the current NASA lunar exploration architecture with a nuclear thermal rocket (NTR). An additional study investigated the possible use of an NTR with existing launch vehicles to provide 21 metric tons of supplies to the lunar surface in support of a lunar outpost. Current cost estimates show that the complete mission cost for an NTR-enhanced assembly of Delta-IV and Atlas V vehicles may cost 47-86% more than the estimated Ares V launch cost of $1.5B; however, development costs for the current NASA architecture have not been assessed. The additional cost of coordinating the rendezvous of four to six launch vehicles with an in-orbit assembly facility also needs more thorough analysis and review. Future trends in launch vehicle use will also significantly impact the results from this comparison. The utility of multiple launch vehicles allows for the development of a more robust and lower risk exploration architecture.

  14. NTR-Enhanced Lunar-Base Supply using Existing Launch Fleet Capabilities

    International Nuclear Information System (INIS)

    Bess, John D.; Colvin, Emily; Cummings, Paul G.

    2009-01-01

    During the summer of 2006, students at the Center for Space Nuclear Research sought to augment the current NASA lunar exploration architecture with a nuclear thermal rocket (NTR). An additional study investigated the possible use of an NTR with existing launch vehicles to provide 21 metric tons of supplies to the lunar surface in support of a lunar outpost. Current cost estimates show that the complete mission cost for an NTR-enhanced assembly of Delta-IV and Atlas V vehicles may cost 47-86% more than the estimated Ares V launch cost of $1.5B; however, development costs for the current NASA architecture have not been assessed. The additional cost of coordinating the rendezvous of four to six launch vehicles with an in-orbit assembly facility also needs more thorough analysis and review. Future trends in launch vehicle use will also significantly impact the results from this comparison. The utility of multiple launch vehicles allows for the development of a more robust and lower risk exploration architecture

  15. Silencing p75NTR prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina

    Directory of Open Access Journals (Sweden)

    Ahmed Y Shanab

    Full Text Available Accumulation of the nerve growth factor precursor (proNGF and its receptor p75NTR have been associated with several neurodegenerative diseases in both brain and retina. However, whether proNGF contributes to microvascular degeneration remain unexplored. This study seeks to investigate the mechanism by which proNGF/p75NTR induce endothelial cell (EC death and development of acellular capillaries, a surrogate marker of retinal ischemia. Stable overexpression of the cleavage-resistant proNGF and molecular silencing of p75NTR were utilized in human retinal EC and rat retinas in vivo. Stable overexpression of proNGF decreased NGF levels and induced retinal vascular cell death evident by 1.9-fold increase in acellular capillaries and activation of JNK and cleaved-PARP that were mitigated by p75NTRshRNA. In vitro, overexpression of proNGF did not alter TNF-α level, reduced NGF, however induced EC apoptosis evident by activation of JNK and p38 MAPK, cleaved-PARP. Silencing p75NTR using siRNA restored expression of NGF and TrkA activation and prevented EC apoptosis. Treatment of EC with human-mutant proNGF induced apoptosis that coincided with marked protein interaction and nuclear translocation of p75NTR and the neurotrophin receptor interacting factor. These effects were abolished by a selective p75NTR antagonist. Therefore, targeting p75NTR represents a potential therapeutic strategy for diseases associated with aberrant expression of proNGF.

  16. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo.

    Science.gov (United States)

    Tong, Xiangjun; Xie, Dong; Roth, Wilfried; Reed, John; Koeffler, H Phillip

    2003-06-01

    NADE, a p75NTR (low-affinity neurotrophin receptor p75) -associated cell death executor, was initially cloned from a human ovarian granulosa cell cDNA library, as an unknown protein with the name, pHGR74. It was reported to mediate nerve growth factor-induced apoptosis. We independently isolated human NADE (pHGR74) from breast cancer cell lines. Expression of NADE in various human cancer cell lines, and human and murine tissues was examined. NADE was highly expressed in human endocrine-related organs and embryotic murine tissues. Forced expression of NADE in CHO (Chinese hamster ovary) cells and MDA-MB-231 human breast cancer cells had little effect on the growth of the cells in vitro, while it dramatically suppressed cellular growth in vivo. We used the yeast two-hybrid system to search for NADE binding protein. Dynactin was identified as a candidate. The p75NTR was not found in this assay and did not co-immunoprecipitate with human NADE. Furthermore, the cells stably transfected with NADE did not respond to NGF or TNF. Thus, human and murine NADE appear to have different functions.

  17. Blocking p75 (NTR) receptors alters polyinnervationz of neuromuscular synapses during development.

    Science.gov (United States)

    Garcia, Neus; Tomàs, Marta; Santafe, Manel M; Lanuza, Maria A; Besalduch, Nuria; Tomàs, Josep

    2011-09-01

    High-resolution immunohistochemistry shows that the receptor protein p75(NTR) is present in the nerve terminal, muscle cell, and glial Schwann cell at the neuromuscular junction (NMJ) of postnatal rats (P4-P6) during the synapse elimination period. Blocking the receptor with the antibody anti-p75-192-IgG (1-5 μg/ml, 1 hr) results in reduced endplate potentials (EPPs) in mono- and polyinnervated synapses ex vivo, but the mean number of functional inputs per NMJ does not change for as long as 3 hr. Incubation with exogenous brain-derived neurotrophic factor (BDNF) for 1 hr (50 nM) resulted in a significant increase in the size of the EPPs in all nerve terminals, and preincubation with anti-p75-192-IgG prevented this potentiation. Long exposure (24 hr) in vivo of the NMJs to the antibody anti-p75-192-IgG (1-2 μg/ml) results in a delay of postnatal synapse elimination and even some regrowth of previously withdrawn axons, but also in some acceleration of the morphologic maturation of the postsynaptic nicotinic acetylcholine receptor (nAChR) clusters. The results indicate that p75(NTR) is involved in both ACh release and axonal retraction during postnatal axonal competition and synapse elimination. Copyright © 2011 Wiley-Liss, Inc.

  18. Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection.

    Science.gov (United States)

    Lee, Jin-Yeon; Kim, Yu-Jin; Kim, Tae-Youn; Koh, Jae-Young; Kim, Yang-Hee

    2008-10-22

    Ischemic preconditioning (PC) of the brain is a phenomenon by which mild ischemic insults render neurons resistant to subsequent strong insults. Key steps in ischemic PC of the brain include caspase-3 activation and poly(ADP-ribose) polymerase-1 (PARP-1) cleavage, but upstream events have not been clearly elucidated. We have tested whether endogenous zinc is required for ischemic PC of the brain in rats. Mild, transient zinc accumulation was observed in certain neurons after ischemic PC. Moreover, intraventricular administration of CaEDTA during ischemic PC abrogated both zinc accumulation and the protective effect against subsequent full ischemia. To elucidate the mechanism of the zinc-triggered PC (Zn PC) effect, cortical cultures were exposed to sublethal levels of zinc, and 18 h later to lethal levels of zinc or NMDA. Zn PC exhibited the characteristic features of ischemic PC, including caspase-3 activation, PARP-1 cleavage, and HSP70 induction, all of which are crucial for subsequent neuroprotection against NMDA or zinc toxicity. HSP70 induction was necessary for protection, as it halted caspase-3 activation before apoptosis. Interestingly, in both Zn PC in vitro and ischemic PC in vivo, p75(NTR) was necessary for neuroprotection. These results suggest that caspase-3 activation during ischemic PC, a necessary event for subsequent neuroprotection, may result from mild zinc accumulation and the consequent p75(NTR) activation in neurons.

  19. p75NTR enhances PC12 cell tumor growth by a non-receptor mechanism involving downregulation of cyclin D2

    International Nuclear Information System (INIS)

    Fritz, Melinda D.; Mirnics, Zeljka K.; Nylander, Karen D.; Schor, Nina F.

    2006-01-01

    p75NTR is a member of the tumor necrosis superfamily of proteins which is variably associated with induction of apoptosis and proliferation. Cyclin D2 is one of the mediators of cellular progression through G1 phase of the cell cycle. The present study demonstrates the inverse relationship between expression of cyclin D2 and expression of p75NTR in PC12 cells. Induction of p75NTR expression in p75NTR-negative PC12 cells results in downregulation of cyclin D2; suppression of p75NTR expression with siRNA in native PC12 cells results in upregulation of cyclin D2. The effects of p75NTR on cyclin D2 expression are mimicked in p75NTR-negative cells by transfection with the intracellular domain of p75NTR. Cyclin-D2-positive PC12 cell cultures grow more slowly than cyclin-D2-negative cultures, and induction of expression of cyclin D2 slows the culture growth rate of cyclin-D2-negative cells. Finally, subcutaneous murine xenografts of cyclin-D2-negative, p75NTR-positive PC12 cells more frequently and more rapidly produce tumors than the analogous xenografts of cyclin-D2-positive, p75NTR-negative cells. These results suggest that p75NTR suppresses cyclin D2 expression in PC12 cells by a mechanism distinct from its function as a nerve growth factor receptor and that cyclin D2 expression decreases cell culture and xenografted tumor growth

  20. Affordable Development and Demonstration of a Small NTR Engine and Stage: How Small is Big Enough?

    Science.gov (United States)

    Borowski, Stanley K.; Sefcik, Robert J.; Fittje, James E.; McCurdy, David R.; Qualls, Arthur L.; Schnitzler, Bruce G.; Werner, James E.; Weitzberg (Abraham); Joyner, Claude R.

    2015-01-01

    The Nuclear Thermal Rocket (NTR) derives its energy from fission of uranium-235 atoms contained within fuel elements that comprise the engine's reactor core. It generates high thrust and has a specific impulse potential of approximately 900 seconds - a 100% increase over today's best chemical rockets. The Nuclear Thermal Propulsion (NTP) project, funded by NASA's AES program, includes five key task activities: (1) Recapture, demonstration, and validation of heritage graphite composite (GC) fuel (selected as the "Lead Fuel" option); (2) Engine Conceptual Design; (3) Operating Requirements Definition; (4) Identification of Affordable Options for Ground Testing; and (5) Formulation of an Affordable Development Strategy. During FY'14, a preliminary DDT&E plan and schedule for NTP development was outlined by GRC, DOE and industry that involved significant system-level demonstration projects that included GTD tests at the NNSS, followed by a FTD mission. To reduce cost for the GTD tests and FTD mission, small NTR engines, in either the 7.5 or 16.5 klbf thrust class, were considered. Both engine options used GC fuel and a "common" fuel element (FE) design. The small approximately 7.5 klbf "criticality-limited" engine produces approximately 157 megawatts of thermal power (MWt) and its core is configured with parallel rows of hexagonal-shaped FEs and tie tubes (TTs) with a FE to TT ratio of approximately 1:1. The larger approximately 16.5 klbf Small Nuclear Rocket Engine (SNRE), developed by LANL at the end of the Rover program, produces approximately 367 MWt and has a FE to TT ratio of approximately 2:1. Although both engines use a common 35 inch (approximately 89 cm) long FE, the SNRE's larger diameter core contains approximately 300 more FEs needed to produce an additional 210 MWt of power. To reduce the cost of the FTD mission, a simple "1-burn" lunar flyby mission was considered to reduce the LH2 propellant loading, the stage size and complexity. Use of existing and

  1. Neurotrophin Receptors TrkA, p75NTR, and Sortilin Are Increased and Targetable in Thyroid Cancer.

    Science.gov (United States)

    Faulkner, Sam; Jobling, Philip; Rowe, Christopher W; Rodrigues Oliveira, S M; Roselli, Severine; Thorne, Rick F; Oldmeadow, Christopher; Attia, John; Jiang, Chen Chen; Zhang, Xu Dong; Walker, Marjorie M; Hondermarck, Hubert

    2018-01-01

    Neurotrophin receptors are emerging targets in oncology, but their clinicopathologic significance in thyroid cancer is unclear. In this study, the neurotrophin tyrosine receptor kinase TrkA (also called NTRK1), the common neurotrophin receptor p75 NTR , and the proneurotrophin receptor sortilin were analyzed with immunohistochemistry in a cohort of thyroid cancers (n = 128) and compared with adenomas and normal thyroid tissues (n = 62). TrkA was detected in 20% of thyroid cancers, compared with none of the benign samples (P = 0.0007). TrkA expression was independent of histologic subtypes but associated with lymph node metastasis (P = 0.0148), suggesting the involvement of TrkA in tumor invasiveness. Nerves in the tumor microenvironment were positive for TrkA. p75 NTR was overexpressed in anaplastic thyroid cancers compared with papillary and follicular subtypes (P Neurotrophin receptor expression was confirmed in a panel of thyroid cancer cell lines at the mRNA and protein levels. Functional investigations using the anaplastic thyroid cancer cell line CAL-62 found that siRNA against TrkA, p75 NTR , and sortilin decreased cell survival and cell migration through decreased SRC and ERK activation. Together, these data reveal TrkA, p75 NTR , and sortilin as potential therapeutic targets in thyroid cancer. Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  2. Subconjunctival Delivery of p75NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy.

    Science.gov (United States)

    Galan, Alba; Barcelona, Pablo F; Nedev, Hinyu; Sarunic, Marinko V; Jian, Yifan; Saragovi, H Uri

    2017-06-01

    The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and neurodegenerative phases of the retinal pathology. To simplify clinical translation, we sought a superior drug delivery method that circumvents risks associated with IVT injections. We compared the pharmacokinetics of a single 40 μg subconjunctival (SCJ) depot to the reported effective 5 μg IVT injections of THX-B. We quantified therapeutic efficacy, with endpoints of inflammation, edema, and neuronal death. The subconjunctival depot affords retinal exposure equal to IVT injection, without resulting in detectable drug in circulation. At week 2 of diabetic retinopathy, the SCJ depot provided therapeutic efficacy similar to IVT injections, with reduced inflammation, reduced edema, reduced neuronal death, and a long-lasting protection of the retinal structure. Subconjunctival injections are a safe and effective route for retinal delivery of p75NTR antagonists. The subconjunctival route offers an advantageous, less-invasive, more compliant, and nonsystemic method to deliver p75NTR antagonists for the treatment of retinal diseases.

  3. Is our Universe typical?

    International Nuclear Information System (INIS)

    Gurzadyan, V.G.

    1988-01-01

    The problem of typicalness of the Universe - as a dynamical system possessing both regular and chaotic regions of positive measure of phase space, is raised and discussed. Two dynamical systems are considered: 1) The observed Universe as a hierarchy of systems of N graviting bodies; 2) (3+1)-manifold with matter evolving to Wheeler-DeWitt equation in superspace with Hawking boundary condition of compact metrics. It is shown that the observed Universe is typical. There is no unambiguous answer for the second system yet. If it is typical too then the same present state of the Universe could have been originated from an infinite number of different initial conditions the restoration of which is practically impossible at present. 35 refs.; 2 refs

  4. Carprofen induction of p75NTR-dependent apoptosis via the p38 mitogen-activated protein kinase pathway in prostate cancer cells.

    Science.gov (United States)

    Khwaja, Fatima S; Quann, Emily J; Pattabiraman, Nagarajan; Wynne, Shehla; Djakiew, Daniel

    2008-11-01

    The p75 neurotrophin receptor (p75(NTR)) functions as a tumor suppressor in prostate epithelial cells, where its expression declines with progression to malignant cancer. Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in several prostate cancer cell lines leading to p75(NTR)-mediated decreased survival. Using the 2-phenyl propionic acid moiety of these profens as a pharmacophore, we screened an in silico database of 30 million compounds and identified carprofen as having an order of magnitude greater activity for induction of p75(NTR) levels and inhibition of cell survival. Prostate (PC-3 and DU-145) and bladder (T24) cancer cells were more sensitive to carprofen induction of p75(NTR)-associated loss of survival than breast (MCF-7) and fibroblast (3T3) cells. Transfection of prostate cell lines with a dominant-negative form of p75(NTR) before carprofen treatment partially rescued cell survival, showing a cause-and-effect relationship between carprofen induction of p75(NTR) levels and inhibition of survival. Carprofen induced apoptotic nuclear fragmentation in prostate but not in MCF-7 and 3T3 cells. Furthermore, small interfering RNA knockdown of the p38 mitogen-activated protein kinase (MAPK) protein prevented induction of p75(NTR) by carprofen in both prostate cell lines. Carprofen treatment induced phosphorylation of p38 MAPK as early as within 1 min. Expression of a dominant-negative form of MK2, the kinase downstream of p38 MAPK frequently associated with signaling cascades leading to apoptosis, prevented carprofen induction of the p75(NTR) protein. Collectively, we identify carprofen as a highly potent profen capable of inducing p75(NTR)-dependent apoptosis via the p38 MAPK pathway in prostate cancer cells.

  5. Typical Complexity Numbers

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Typical Complexity Numbers. Say. 1000 tones,; 100 Users,; Transmission every 10 msec. Full Crosstalk cancellation would require. Full cancellation requires a matrix multiplication of order 100*100 for all the tones. 1000*100*100*100 operations every second for the ...

  6. Typicality and reasoning fallacies.

    Science.gov (United States)

    Shafir, E B; Smith, E E; Osherson, D N

    1990-05-01

    The work of Tversky and Kahneman on intuitive probability judgment leads to the following prediction: The judged probability that an instance belongs to a category is an increasing function of the typicality of the instance in the category. To test this prediction, subjects in Experiment 1 read a description of a person (e.g., "Linda is 31, bright, ... outspoken") followed by a category. Some subjects rated how typical the person was of the category, while others rated the probability that the person belonged to that category. For categories like bank teller and feminist bank teller: (1) subjects rated the person as more typical of the conjunctive category (a conjunction effect); (2) subjects rated it more probable that the person belonged to the conjunctive category (a conjunction fallacy); and (3) the magnitudes of the conjunction effect and fallacy were highly correlated. Experiment 2 documents an inclusion fallacy, wherein subjects judge, for example, "All bank tellers are conservative" to be more probable than "All feminist bank tellers are conservative." In Experiment 3, results parallel to those of Experiment 1 were obtained with respect to the inclusion fallacy.

  7. Typicals/Típicos

    Directory of Open Access Journals (Sweden)

    Silvia Vélez

    2004-01-01

    Full Text Available Typicals is a series of 12 colour photographs digitally created from photojournalistic images from Colombia combined with "typical" craft textiles and text from guest writers. Typicals was first exhibited as photographs 50cm x 75cm in size, each with their own magnifying glass, at the Contemporary Art Space at Gorman House in Canberra, Australia, in 2000. It was then exhibited in "Feedback: Art Social Consciousness and Resistance" at Monash University Museum of Art in Melbourne, Australia, from March to May 2003. From May to June 2003 it was exhibited at the Museo de Arte de la Universidad Nacional de Colombia Santa Fé Bogotá, Colombia. In its current manifestation the artwork has been adapted from the catalogue of the museum exhibitions. It is broken up into eight pieces corresponding to the contributions of the writers. The introduction by Sylvia Vélez is the PDF file accessible via a link below this abstract. The other seven PDF files are accessible via the 'Supplementary Files' section to the left of your screen. Please note that these files are around 4 megabytes each, so it may be difficult to access them from a dial-up connection.

  8. Implementation of a Gadolinium Burnable Absorber in the Carbide LEU-NTR

    International Nuclear Information System (INIS)

    Venneria, Paolo; Kim, Yonghee

    2015-01-01

    Among the most crucial are the rapid reactivity depletion during full-power operation and the positive reactivity insertion during the full-submersion criticality accident. In previous work, it has been suggested that both challenges can be mitigated through the successful implementation of a burnable absorber in the active core. Of the poisons previously surveyed, one of the most promising is Gadolinium in the form of Gadolina (Gd2O4). This paper explores the possibility of different methods by which the Gadolinia can be implemented in the core and makes a preliminary study of its effect on the full submersion criticality accident and the reactivity depletion during operation. The application of a Gadolinium neutron absorber in the active core region of the LEU-NTR has been shown to be neutronically feasible. It can be introduced into the core in various locations without resulting in core performance loss. The utility of the poison in terms of mitigating the full-submersion reactivity accident and the rapid change in reactivity during full-power operation have been preliminarily shown and the first steps towards eventual implementation made. Future work will consist of determining the maximum poison content in the core and tailoring the self-shielding effect in order to determine a specific Gd depletion rate

  9. Conventional and Bimodal Nuclear Thermal Rocket (NTR) Artificial Gravity Mars Transfer Vehicle Concepts

    Science.gov (United States)

    Borowski, Stanley K.; McCurdy, David R.; Packard, Thomas W.

    2016-01-01

    A variety of countermeasures have been developed to address the debilitating physiological effects of zero-gravity (0-g) experienced by cosmonauts and astronauts during their approximately 0.5 to 1.2 year long stays in low Earth orbit (LEO). Longer interplanetary flights, combined with possible prolonged stays in Mars orbit, could subject crewmembers to up to approximately 2.5 years of weightlessness. In view of known and recently diagnosed problems associated with 0-g, an artificial gravity (AG) spacecraft offers many advantages and may indeed be an enabling technology for human flights to Mars. A number of important human factors must be taken into account in selecting the rotation radius, rotation rate, and orientation of the habitation module or modules. These factors include the gravity gradient effect, radial and tangential Coriolis forces, along with cross-coupled acceleration effects. Artificial gravity Mars transfer vehicle (MTV) concepts are presented that utilize both conventional NTR, as well as, enhanced bimodal nuclear thermal rocket (BNTR) propulsion. The NTR is a proven technology that generates high thrust and has a specific impulse (Isp) capability of approximately 900 s-twice that of today's best chemical rockets. The AG/MTV concepts using conventional Nuclear Thermal Propulsion (NTP) carry twin cylindrical International Space Station (ISS)- type habitation modules with their long axes oriented either perpendicular or parallel to the longitudinal spin axis of the MTV and utilize photovoltaic arrays (PVAs) for spacecraft power. The twin habitat modules are connected to a central operations hub located at the front of the MTV via two pressurized tunnels that provide the rotation radius for the habitat modules. For the BNTR AG/MTV option, each engine has its own closed secondary helium(He)-xenon (Xe) gas loop and Brayton Rotating Unit (BRU) that can generate 10s of kilowatts (kWe) of spacecraft electrical power during the mission coast phase

  10. A Typical Synergy

    Science.gov (United States)

    van Noort, Thomas; Achten, Peter; Plasmeijer, Rinus

    We present a typical synergy between dynamic types (dynamics) and generalised algebraic datatypes (GADTs). The former provides a clean approach to integrating dynamic typing in a statically typed language. It allows values to be wrapped together with their type in a uniform package, deferring type unification until run time using a pattern match annotated with the desired type. The latter allows for the explicit specification of constructor types, as to enforce their structural validity. In contrast to ADTs, GADTs are heterogeneous structures since each constructor type is implicitly universally quantified. Unfortunately, pattern matching only enforces structural validity and does not provide instantiation information on polymorphic types. Consequently, functions that manipulate such values, such as a type-safe update function, are cumbersome due to boilerplate type representation administration. In this paper we focus on improving such functions by providing a new GADT annotation via a natural synergy with dynamics. We formally define the semantics of the annotation and touch on novel other applications of this technique such as type dispatching and enforcing type equality invariants on GADT values.

  11. The p75NTR mediates a bifurcated signal transduction cascade through the NFκB and JNK pathways to inhibit cell survival

    International Nuclear Information System (INIS)

    Allen, Jeffrey; Khwaja, Fatima; Byers, Stephen; Djakiew, Daniel

    2005-01-01

    p75 NTR is most abundantly expressed in the nervous system, but is also widely expressed in many other organs and tissues where it primarily functions as a negative regulator of cell survival. In the prostate, p75 NTR functions as an inhibitory protein capable of slowing proliferation and inducing apoptosis. It has been shown that p75 NTR is expressed in the normal prostate, progressively lost from malignant tumor cells in vivo, and largely absent from prostate cancer cell lines derived from metastases. Although the role of p75 NTR in prostate cancer has been well established, the signal transduction pathway that mediates its inhibitory activity has only been partially elucidated. This study demonstrates that exogenous expression of p75 NTR down-regulates, in a dose-dependent manner, a bifurcated signaling cascade that results in reduced expression of potent transcription effectors. This two-arm signal transduction cascade was directly linked to the upstream receptor by using dominant-negative deletion constructs of p75 NTR that rescued tumor cells from p75 NTR -induced loss of survival and promotion of apoptosis. Furthermore, the dominant negatives rescued alterations in the levels of signal transduction intermediates. Conversely, the use of kinase-inactive intermediates that are downstream of the receptor further reduced expression of involved transcription effectors and reduced survival of the cells. These results provide a definitive link between the proximate p75 NTR and signal transduction intermediates leading to the transcription effectors NFκB and JNK, with associated growth suppression and induction of apoptosis

  12. Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat.

    Science.gov (United States)

    Yi, Jung-Sun; Lee, Soon-Keum; Sato, Taka-Aki; Koh, Jae-Young

    2003-08-21

    Zinc induces in cultured cortical neurons both p75(NTR) and p75(NTR)-associated death executor (NADE), which together contribute to caspase-dependent neuronal apoptosis. Since zinc neurotoxicity may contribute to neuronal death following seizures, we examined whether p75(NTR) and NADE are co-induced also in rat hippocampal neurons degenerating after seizures. Staining of brain sections with a zinc-specific fluorescent dye (N-(6-methoxy-8-quinolyl)-p-carboxybenzoylsulphonamide) and acid fuchsin revealed zinc accumulation in degenerating neuronal cell bodies in CA1 and CA3 of hippocampus 24 h after kainate injection. Both anti-p75(NTR) and anti-NADE immunoreactivities appeared in zinc-accumulating/degenerating neurons in both areas. Intraventricular injection of CaEDTA, without altering the severity or time course of kainate-induced seizures, markedly attenuated the induction of p75(NTR)/NADE in hippocampus, which correlated with the decrease of caspase-3 activation and zinc accumulation/cell death. The present study has demonstrated that p75(NTR) and NADE are co-induced in neurons degenerating after kainate-induced seizures in rats, likely in a zinc-dependent manner.

  13. The transcriptional regulator NtrC controls glucose-6-phosphate dehydrogenase expression and polyhydroxybutyrate synthesis through NADPH availability in Herbaspirillum seropedicae.

    Science.gov (United States)

    Sacomboio, Euclides Nenga Manuel; Kim, Edson Yu Sin; Correa, Henrique Leonardo Ruchaud; Bonato, Paloma; Pedrosa, Fabio de Oliveira; de Souza, Emanuel Maltempi; Chubatsu, Leda Satie; Müller-Santos, Marcelo

    2017-10-19

    The NTR system is the major regulator of nitrogen metabolism in Bacteria. Despite its broad and well-known role in the assimilation, biosynthesis and recycling of nitrogenous molecules, little is known about its role in carbon metabolism. In this work, we present a new facet of the NTR system in the control of NADPH concentration and the biosynthesis of molecules dependent on reduced coenzyme in Herbaspirillum seropedicae SmR1. We demonstrated that a ntrC mutant strain accumulated high levels of polyhydroxybutyrate (PHB), reaching levels up to 2-fold higher than the parental strain. In the absence of NtrC, the activity of glucose-6-phosphate dehydrogenase (encoded by zwf) increased by 2.8-fold, consequently leading to a 2.1-fold increase in the NADPH/NADP + ratio. A GFP fusion showed that expression of zwf is likewise controlled by NtrC. The increase in NADPH availability stimulated the production of polyhydroxybutyrate regardless the C/N ratio in the medium. The mutant ntrC was more resistant to H 2 O 2 exposure and controlled the propagation of ROS when facing the oxidative condition, a phenotype associated with the increase in PHB content.

  14. The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/CD271).

    Science.gov (United States)

    Alshehri, M M; Robbins, S M; Senger, D L

    2017-01-01

    The p75 neurotrophin receptor (p75 NTR , a.k.a. CD271), a transmembrane glycoprotein and a member of the tumor necrosis family (TNF) of receptors, was originally identified as a nerve growth factor receptor in the mid-1980s. While p75 NTR is recognized to have important roles during neural development, its presence in both neural and nonneural tissues clearly supports the potential to mediate a broad range of functions depending on cellular context. Using an unbiased in vivo selection paradigm for genes underlying the invasive behavior of glioma, a critical characteristic that contributes to poor clinical outcome for glioma patients, we identified p75 NTR as a central regulator of glioma invasion. Herein we review the expanding role that p75 NTR plays in glioma progression with an emphasis on how p75 NTR may contribute to the treatment refractory nature of glioma. Based on the observation that p75 NTR is expressed and functional in two critical glioma disease reservoirs, namely, the highly infiltrative cells that evade surgical resection, and the radiation- and chemotherapy-resistant brain tumor-initiating cells (also referred to as brain tumor stem cells), we propose that p75 NTR and its myriad of downstream signaling effectors represent rationale therapeutic targets for this devastating disease. Lastly, we provide the provocative hypothesis that, in addition to the well-documented cell autonomous signaling functions, the neurotrophins, and their respective receptors, contribute in a cell nonautonomous manner to drive the complex cellular and molecular composition of the brain tumor microenvironment, an environment that fuels tumorigenesis. © 2017 Elsevier Inc. All rights reserved.

  15. Nitrate assimilation pathway (NAP): role of structural (nit) and transporter (ntr1) genes in Fusarium oxysporum f.sp. lycopersici growth and pathogenicity.

    Science.gov (United States)

    Gomez-Gil, Lucia; Camara Almiron, Jesus; Rodriguez Carrillo, Patricia Lizett; Olivares Medina, Cindy Nayely; Bravo Ruiz, Gustavo; Romo Rodriguez, Pamela; Corrales Escobosa, Alma Rosa; Gutierrez Corona, Felix; Roncero, M Isabel

    2018-04-01

    The tomato pathogen Fusarium oxysporum f.sp. lycopersici possesses the capability to use nitrate as the only nitrogen source under aerobic and anaerobic conditions and to activate virulence-related functions when cultivated in the presence of nitrate, but not in ammonium. The genome of F. oxysporum f.sp. lycopersici encodes three paralogs nitrate reductase (NR) genes (nit1, nit2 and nit3) and one predicted ortholog of the Aspergillus nidulans high-affinity nitrate/nitrite transporters NtrA and NtrB, named ntr1. We set out to clarify the role of nit1, nit2, nit3 and ntr1 genes in nitrate assimilation and in the virulence of F. oxysporum f.sp. lycopersici. Quantitative RT-PCR analysis revealed that only nit1, nit2 and ntr1 are expressed at significant levels during growth in nitrate as the only nitrogen source. Targeted deletion of nit1 and ntr1, but not of nit2 or nit3, severely impaired growth of F. oxysporum on nitrate as nitrogen source, indicating that Nit1 and Ntr1 proteins are involved in nitrate assimilation by the fungus; biochemical analysis of nit mutants indicated that Nit1 and Nit2 enzymes contribute to about 50 and 30% of the total NR activity, respectively. In addition, a spontaneous chlorate-resistant mutant derived from F. oxysporum 4287, denoted NitFG, was characterized, showing inability to grow in nitrate under aerobic and anaerobic conditions and low levels of NR activity, in spite of its increased transcription levels of nit1 and nit2 genes. Tomato plant infection assays showed that NitFG and ∆ntr1 mutants induced an earlier death in tomato plants, whereas the single mutants ∆nit1, ∆nit2 and ∆nit1∆nit2 double mutant showed a mortality rate similar to the wild-type strain. Taken together, these results indicate that the Nit1 and Ntr1 proteins are important for nitrate assimilation of F. oxysporum f.sp. lycopersici incubated under aerobic and anaerobic conditions and that this metabolic process is not essential for the virulence of

  16. Subclinical hypothyroidism in pregnant rats impaired learning and memory of their offspring by promoting the p75NTR signal pathway

    Directory of Open Access Journals (Sweden)

    Fan Zhang

    2018-05-01

    Full Text Available Objective: Maternal hypothyroidism during pregnancy can affect the neurodevelopment of their offspring. This study aimed to investigate the effects of maternal subclinical hypothyroidism (SCH on spatial learning and memory, and its relationship with the apoptotic factors in cerebral cortex of the offspring. Methods: Female adult Wistar rats were randomly divided into three groups (n = 15 per group: control (CON group, SCH group and overt hypothyroidism (OH group. Spatial learning and memory in the offspring were evaluated by long-term potentiation (LTP and Morris water-maze (MWM test. The protein expression of the p75 neurotrophin receptor (p75NTR, phospho-c-Jun N-terminal kinase (p-JNK, the pro-apoptotic protein p53 and Bax were detected by Western blotting. Results: The Pups in the SCH and OH groups showed longer escape latencies in the MWM and decreased field-excitatory post synaptic potentials in LTP tests compared with those in the CON group. p75NTR, p-JNK, p53 and Bax expression levels in the cerebral cortex increased in pups in the SCH and OH groups compared with those in the CON group. Conclusions: Maternal SCH during pregnancy may impair spatial learning and memory in the offspring and may be associated with the increased apoptosis in the cerebral cortex.

  17. De Slavernij is onze geschiedenis (niet. Over de discursieve strijd om de betekenis van de ntr- televisieserie De Slavernij

    Directory of Open Access Journals (Sweden)

    Guno Jones

    2012-12-01

    Full Text Available Slavery is (Not Our History: On the Public Debate and Divergent Meanings of theNTR Television Series SlaveryThis article discusses the debates that followed the broadcasting of Dutch NTR-television series Slavery (De Slavernij in 2011. While the series was aimed at informing the general public about this silenced part of Dutch history, the subsequent debates on the series revealed fault lines in Dutch society with regard to ideas on how to know and represent slavery adequately. Although most participants, in line of a positivist epistemology, made appeals to historical facts, these debates clearly demonstrated how knowledge and representations of slavery are positioned in a social and academic field that is always characterised by power relations. Postcolonial critics, whose voices are underrepresented in Dutch academia and media, held very different perspectives on the nature of ‘valid’ paradigms, ‘true’ facts, ‘proper’ interpretations, ‘appropriate’ historical referents and representations concerning slavery to people who praised the series. These polarised debates pose the question of how to engage with the history of slavery without resorting to (biological essentialism that is precisely one of its potent legacies ‘we’ want to overcome.

  18. Vehicle and Mission Design Options for the Human Exploration of Mars/Phobos Using "Bimodal" NTR and LANTR Propulsion

    Science.gov (United States)

    Borowski, Stanley K.; Dudzinski, Leonard A.; McGuire, Melissa L.

    2002-12-01

    The nuclear thermal rocket (NTR) is one of the leading propulsion options for future human missions to Mars because of its high specific impulse (1sp is approximately 850-1000 s) capability and its attractive engine thrust-to-weight ratio (approximately 3-10). To stay within the available mass and payload volume limits of a "Magnum" heavy lift vehicle, a high performance propulsion system is required for trans-Mars injection (TMI). An expendable TMI stage, powered by three 15 thousand pounds force (klbf) NTR engines is currently under consideration by NASA for its Design Reference Mission (DRM). However, because of the miniscule burnup of enriched uranium-235 during the Earth departure phase (approximately 10 grams out of 33 kilograms in each NTR core), disposal of the TMI stage and its engines after a single use is a costly and inefficient use of this high performance stage. By reconfiguring the engines for both propulsive thrust and modest power generation (referred to as "bimodal" operation), a robust, multiple burn, "power-rich" stage with propulsive Mars capture and reuse capability is possible. A family of modular bimodal NTR (BNTR) vehicles are described which utilize a common "core" stage powered by three 15 klbf BNTRs that produce 50 kWe of total electrical power for crew life support, an active refrigeration / reliquification system for long term, zero-boiloff liquid hydrogen (LH2) storage, and high data rate communications. An innovative, spine-like "saddle truss" design connects the core stage and payload element and is open underneath to allow supplemental "in-line" propellant tanks and contingency crew consumables to be easily jettisoned to improve vehicle performance. A "modified" DRM using BNTR transfer vehicles requires fewer transportation system elements, reduces IMLEO and mission risk, and simplifies space operations. By taking the next logical step--use of the BNTR for propulsive capture of all payload elements into Mars orbit--the power

  19. Affordable Development and Demonstration of a Small NTR Engine and Stage: A Preliminary NASA, DOE, and Industry Assessment

    Science.gov (United States)

    Borowski, Stanley K.; Sefcik, Robert J.; Fittje, James E.; McCurdy, David R.; Qualls, Arthur L.; Schnitzler, Bruce G.; Werner, James E.; Weitzberg, Abraham; Joyner, Claude R.

    2015-01-01

    The Nuclear Thermal Rocket (NTR) represents the next evolutionary step in cryogenic liquid rocket engines. Deriving its energy from fission of uranium-235 atoms contained within fuel elements that comprise the engine's reactor core, the NTR can generate high thrust at a specific impulse of approx. 900 seconds or more - twice that of today's best chemical rockets. In FY'11, as part of the AISP project, NASA proposed a Nuclear Thermal Propulsion (NTP) effort that envisioned two key activities - "Foundational Technology Development" followed by system-level "Technology Demonstrations". Five near-term NTP activities identified for Foundational Technology Development became the basis for the NCPS project started in FY'12 and funded by NASA's AES program. During Phase 1 (FY'12-14), the NCPS project was focused on (1) Recapturing fuel processing techniques and fabricating partial length "heritage" fuel elements for the two candidate fuel forms identified by NASA and the DOE - NERVA graphite "composite" and the uranium dioxide (UO2) in tungsten "cermet". The Phase 1 effort also included: (2) Engine Conceptual Design; (3) Mission Analysis and Requirements Definition; (4) Identification of Affordable Options for Ground Testing; and (5) Formulation of an Affordable and Sustainable NTP Development Strategy. During FY'14, a preliminary plan for DDT&E was outlined by GRC, the DOE and industry for NASA HQ that involved significant system-level demonstration projects that included GTD tests at the NNSS, followed by a FTD mission. To reduce development costs, the GTD and FTD tests use a small, low thrust (approx. 7.5 or 16.5 klbf) engine. Both engines use graphite composite fuel and a "common" fuel element design that is scalable to higher thrust (approx. 25 klbf) engines by increasing the number of elements in a larger diameter core that can produce greater thermal power output. To keep the FTD mission cost down, a simple "1-burn" lunar flyby mission was considered along with

  20. The gene suicide system NTR/CB1954 causes ablation of differentiated 3T3L1 adipocytes by apoptosis

    Directory of Open Access Journals (Sweden)

    RICARDO N FELMER

    2004-01-01

    Full Text Available The feasibility of ablating differentiated adipocytes and the mechanism of cell ablation with a suitable prodrug activating system is described. The system is based on the use of E. coli nitroreductase (NTR enzyme that activates certain nitro compounds, such as the antitumor drug CB1954, into cytotoxic DNA interstrand cross-linking agents. Differentiated preadipocyte cells (3T3L1 transfected with an aP2 driven nitroreductase construct were efficiently killed after incubation with medium containing the prodrug CB1954, while untransfected cells were not affected. It was demonstrated that the mechanism of cell ablation is apoptosis and that the system has a bystander effect mediated by a toxic metabolite of the prodrug. The described system should provide a good alternative approach for gene therapy studies and a new inducible approach to manipulating the number of cells in tissues of transgenic animals and the ability to study the recovery of the tissue from cell damage or loss

  1. Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats

    Directory of Open Access Journals (Sweden)

    Ashley M. Fortress

    2011-01-01

    Full Text Available Learning and memory impairments occurring with Alzheimer's disease (AD are associated with degeneration of the basal forebrain cholinergic neurons (BFCNs. BFCNs extend their axons to the hippocampus where they bind nerve growth factor (NGF which is retrogradely transported to the cell body. While NGF is necessary for BFCN survival and function via binding to the high-affinity receptor TrkA, its uncleaved precursor, pro-NGF has been proposed to induce neurodegeneration via binding to the p75NTR and its coreceptor sortilin. Basal forebrain TrkA and NGF are downregulated with aging while pro-NGF is increased. Given these data, the focus of this paper was to determine a mechanism for how pro-NGF accumulation may induce BFCN degeneration. Twenty-four hours after a single injection of pro-NGF into hippocampus, we found increased hippocampal p75NTR levels, decreased hippocampal TrkA levels, and cholinergic degeneration. The data suggest that the increase in p75NTR with AD may be mediated by elevated pro-NGF levels as a result of decreased cleavage, and that pro-NGF may be partially responsible for age-related degenerative changes observed in the basal forebrain. This paper is the first in vivo evidence that pro-NGF can affect BFCNs and may do so by regulating expression of p75NTR neurotrophin receptors.

  2. Establishing a cellular FRET-based fluorescence plate reader assay to monitor proNGF-induced cross-linking of sortilin and the neurotrophin receptor p75(NTR)

    DEFF Research Database (Denmark)

    Skeldal, Sune; Kjaergaard, Maj M; Alwasel, Saleh

    2015-01-01

    the vps10p domain receptor sortilin and the neurotrophin receptor p75(NTR). However, proNGF-induced receptor complex formation has been difficult to directly assess other than by western blotting. We here describe a fluorescence resonance energy transfer (FRET) based fluorescence plate reader assay...

  3. Effect of an ntrC mutation on amino acid or urea utilization and on nitrogenase switch-off in Herbaspirillum seropedicae.

    Science.gov (United States)

    Gusso, Claudio L; de Souza, Emanuel M; Rigo, Liu Un; de Oliveira Pedrosa, Fábio; Yates, M G; de M Rego, Fabiane G; Klassen, Giseli

    2008-03-01

    Herbaspirillum seropedicae is a nitrogen-fixing bacterium that grows well with ammonium chloride or sodium nitrate as alternative single nitrogen sources but that grows more slowly with L-alanine, L-serine, L-proline, or urea. The ntrC mutant strain DCP286A was able to utilize only ammonium or urea of these nitrogen sources. The addition of 1 mmol.L-1 ammonium chloride to the nitrogen-fixing wild-type strain inhibited nitrogenase activity rapidly and completely. Urea was a less effective inhibitor; approximately 20% of nitrogenase activity remained 40 min after the addition of 1 mmol x L-1 urea. The effect of the ntrC mutation on nitrogenase inhibition (switch-off) was studied in strain DCP286A containing the constitutively expressed gene nifA of H. seropedicae. In this strain, nitrogenase inhibition by ammonium was completely abolished, but the addition of urea produced a reduction in nitrogenase activity similar to that of the wild-type strain. The results suggest that the NtrC protein is required for assimilation of nitrate and the tested amino acids by H. seropedicae. Furthermore, NtrC is also necessary for ammonium-induced switch-off of nitrogenase but is not involved in the mechanism of nitrogenase switch-off by urea.

  4. Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles

    NARCIS (Netherlands)

    Caporali, Andrea; Pani, Elisabetta; Horrevoets, Anton J. G.; Kraenkel, Nicolle; Oikawa, Atsuhiko; Sala-Newby, Graciela B.; Meloni, Marco; Cristofaro, Brunella; Graiani, Gallia; Leroyer, Aurelie S.; Boulanger, Chantal M.; Spinetti, Gaia; Yoon, Sung Ok; Madeddu, Paolo; Emanueli, Costanza

    2008-01-01

    Diabetes impairs endothelial function and reparative neovascularization. The p75 receptor of neurotrophins (p75(NTR)), which is scarcely present in healthy endothelial cells (ECs), becomes strongly expressed by capillary ECs after induction of peripheral ischemia in type-1 diabetic mice. Here, we

  5. Human lunar mission capabilities using SSTO, ISRU and LOX-augmented NTR technologies: A preliminary assessment

    Science.gov (United States)

    Borowski, Stanley K.

    1995-10-01

    The feasibility of conducting human missions to the Moon is examined assuming the use of three 'high leverage' technologies: (1) a single-stage-to-orbit (SSTO) launch vehicle, (2) 'in-situ' resource utilization (ISRU)--specifically 'lunar-derived' liquid oxygen (LUNOX), and (3) LOX-augmented nuclear thermal rocket (LANTR) propulsion. Lunar transportation system elements consisting of a LANTR-powered lunar transfer vehicle (LTV) and a chemical propulsion lunar landing/Earth return vehicle (LERV) are configured to fit within the 'compact' dimensions of the SSTO cargo bay (diameter: 4.6 m/length: 9.0 m) while satisfying an initial mass in low Earth orbit (IMLEO) limit of approximately 60 t (3 SSTO launches). Using approximately 8 t of LUNOX to 'reoxidize' the LERV for a 'direct return' flight to Earth reduces its size and mass allowing delivery to LEO on a single 20 t SSTO launch. Similarly, the LANTR engine's ability to operate at any oxygen/ hydrogen mixture ratio from 0 to 7 with high specific impulse (approximately 940 to 515 s) is exploited to reduce hydrogen tank volume, thereby improving packaging of the LANTR LTV's 'propulsion' and 'propellant modules'. Expendable and reusable, piloted and cargo missions and vehicle designs are presented along with estimates of LUNOX production required to support the different mission modes. Concluding remarks address the issue of lunar transportation system costs from the launch vehicle perspective.

  6. Testing typicality in multiverse cosmology

    Science.gov (United States)

    Azhar, Feraz

    2015-05-01

    In extracting predictions from theories that describe a multiverse, we face the difficulty that we must assess probability distributions over possible observations prescribed not just by an underlying theory, but by a theory together with a conditionalization scheme that allows for (anthropic) selection effects. This means we usually need to compare distributions that are consistent with a broad range of possible observations with actual experimental data. One controversial means of making this comparison is by invoking the "principle of mediocrity": that is, the principle that we are typical of the reference class implicit in the conjunction of the theory and the conditionalization scheme. In this paper, we quantitatively assess the principle of mediocrity in a range of cosmological settings, employing "xerographic distributions" to impose a variety of assumptions regarding typicality. We find that for a fixed theory, the assumption that we are typical gives rise to higher likelihoods for our observations. If, however, one allows both the underlying theory and the assumption of typicality to vary, then the assumption of typicality does not always provide the highest likelihoods. Interpreted from a Bayesian perspective, these results support the claim that when one has the freedom to consider different combinations of theories and xerographic distributions (or different "frameworks"), one should favor the framework that has the highest posterior probability; and then from this framework one can infer, in particular, how typical we are. In this way, the invocation of the principle of mediocrity is more questionable than has been recently claimed.

  7. Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines

    International Nuclear Information System (INIS)

    Olszewski-Hamilton, Ulrike; Hamilton, Gerhard

    2011-01-01

    Pancreatic adenocarcinoma is a devastating disease characterized by early dissemination and poor prognosis. These solid tumors express receptors for neuropeptides like neurotensin (NT) or epidermal growth factor (EGF) and exhibit acidic regions when grown beyond a certain size. We previously demonstrated increases in intracellular Ca 2+ levels, intracellular pH and interleukin-8 (IL-8) secretion in BxPC-3 and PANC-1 pancreatic cancer cells in response to a stable NT analog. The present study aimed at investigation of the dependence of the relative expression of NT receptor 1 (NTR1) and EGFR in BxPC-3 and MIA PaCa-2 cells on cell density and extracellular pH (pH e ). MTT assays revealed the NTR1 inhibitor SR 142948-sensitive Lys 8 -ψ-Lys 9 NT (8–13)-induced proliferation in BxPC-3 and PANC-1 cells. Confluent cultures of BxPC3 and HT-29 lines exhibited highest expression of NTR1 and lowest of EGFR and expression of NTR1 was maximal at slightly acidic pH e . IL-8 production was stimulated by Lys 8 -ψ-Lys 9 NT (8–13) and even enhanced at both acidic and alkaline pH e in BxPC-3 and PANC-1 cells. In conclusion, our in vitro study suggests that one contributing factor to the minor responses obtained with EGFR-directed therapy may be downregulation of this receptor in tumor cell aggregates, possibly resulting in acquisition of a more aggressive phenotype via other growth factor receptors like NTR1

  8. Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence

    Energy Technology Data Exchange (ETDEWEB)

    Xu, R.; Duan, S.R.; Zhao, J.W.; Wang, C.Y. [Neurology Ward of Internal Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province (China)

    2015-06-23

    Chronic ethanol consumption can produce learning and memory deficits. Brain-derived neurotrophic factor (BDNF) and its receptors affect the pathogenesis of alcoholism. In this study, we examined the expression of BDNF, tropomyosin receptor kinase B (TrkB) and p75 neurotrophin receptor (p75NTR) in the hippocampus of a dog model of chronic alcoholism and abstinence. Twenty domestic dogs (9-10 months old, 15-20 kg; 10 males and 10 females) were obtained from Harbin Medical University. A stable alcoholism model was established through ad libitum feeding, and anti-alcohol drug treatment (Zhong Yao Jie Jiu Ling, the main ingredient was the stems of watermelon; developed in our laboratory), at low- and high-doses, was carried out. The Zhong Yao Jie Jiu Ling was effective for the alcoholism in dogs. The morphology of hippocampal neurons was evaluated using hematoxylin-eosin staining. The number and morphological features of BDNF, TrkB and p75NTR-positive neurons in the dentate gyrus (DG), and the CA1, CA3 and CA4 regions of the hippocampus were observed using immunohistochemistry. One-way ANOVA was used to determine differences in BDNF, TrkB and p75NTR expression. BDNF, TrkB and p75NTR-positive cells were mainly localized in the granular cell layer of the DG and in the pyramidal cell layer of the CA1, CA3 and CA4 regions (DG>CA1>CA3>CA4). Expression levels of both BDNF and TrkB were decreased in chronic alcoholism, and increased after abstinence. The CA4 region appeared to show the greatest differences. Changes in p75NTR expression were the opposite of those of BDNF and TrkB, with the greatest differences observed in the DG and CA4 regions.

  9. Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence

    Directory of Open Access Journals (Sweden)

    R. Xu

    2015-08-01

    Full Text Available Chronic ethanol consumption can produce learning and memory deficits. Brain-derived neurotrophic factor (BDNF and its receptors affect the pathogenesis of alcoholism. In this study, we examined the expression of BDNF, tropomyosin receptor kinase B (TrkB and p75 neurotrophin receptor (p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence. Twenty domestic dogs (9-10 months old, 15-20 kg; 10 males and 10 females were obtained from Harbin Medical University. A stable alcoholism model was established through ad libitum feeding, and anti-alcohol drug treatment (Zhong Yao Jie Jiu Ling, the main ingredient was the stems of watermelon; developed in our laboratory, at low- and high-doses, was carried out. The Zhong Yao Jie Jiu Ling was effective for the alcoholism in dogs. The morphology of hippocampal neurons was evaluated using hematoxylin-eosin staining. The number and morphological features of BDNF, TrkB and p75NTR-positive neurons in the dentate gyrus (DG, and the CA1, CA3 and CA4 regions of the hippocampus were observed using immunohistochemistry. One-way ANOVA was used to determine differences in BDNF, TrkB and p75NTR expression. BDNF, TrkB and p75NTR-positive cells were mainly localized in the granular cell layer of the DG and in the pyramidal cell layer of the CA1, CA3 and CA4 regions (DG>CA1>CA3>CA4. Expression levels of both BDNF and TrkB were decreased in chronic alcoholism, and increased after abstinence. The CA4 region appeared to show the greatest differences. Changes in p75NTR expression were the opposite of those of BDNF and TrkB, with the greatest differences observed in the DG and CA4 regions.

  10. Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence

    International Nuclear Information System (INIS)

    Xu, R.; Duan, S.R.; Zhao, J.W.; Wang, C.Y.

    2015-01-01

    Chronic ethanol consumption can produce learning and memory deficits. Brain-derived neurotrophic factor (BDNF) and its receptors affect the pathogenesis of alcoholism. In this study, we examined the expression of BDNF, tropomyosin receptor kinase B (TrkB) and p75 neurotrophin receptor (p75NTR) in the hippocampus of a dog model of chronic alcoholism and abstinence. Twenty domestic dogs (9-10 months old, 15-20 kg; 10 males and 10 females) were obtained from Harbin Medical University. A stable alcoholism model was established through ad libitum feeding, and anti-alcohol drug treatment (Zhong Yao Jie Jiu Ling, the main ingredient was the stems of watermelon; developed in our laboratory), at low- and high-doses, was carried out. The Zhong Yao Jie Jiu Ling was effective for the alcoholism in dogs. The morphology of hippocampal neurons was evaluated using hematoxylin-eosin staining. The number and morphological features of BDNF, TrkB and p75NTR-positive neurons in the dentate gyrus (DG), and the CA1, CA3 and CA4 regions of the hippocampus were observed using immunohistochemistry. One-way ANOVA was used to determine differences in BDNF, TrkB and p75NTR expression. BDNF, TrkB and p75NTR-positive cells were mainly localized in the granular cell layer of the DG and in the pyramidal cell layer of the CA1, CA3 and CA4 regions (DG>CA1>CA3>CA4). Expression levels of both BDNF and TrkB were decreased in chronic alcoholism, and increased after abstinence. The CA4 region appeared to show the greatest differences. Changes in p75NTR expression were the opposite of those of BDNF and TrkB, with the greatest differences observed in the DG and CA4 regions

  11. Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence.

    Science.gov (United States)

    Xu, R; Duan, S R; Zhao, J W; Wang, C Y

    2015-08-01

    Chronic ethanol consumption can produce learning and memory deficits. Brain-derived neurotrophic factor (BDNF) and its receptors affect the pathogenesis of alcoholism. In this study, we examined the expression of BDNF, tropomyosin receptor kinase B (TrkB) and p75 neurotrophin receptor (p75NTR) in the hippocampus of a dog model of chronic alcoholism and abstinence. Twenty domestic dogs (9-10 months old, 15-20 kg; 10 males and 10 females) were obtained from Harbin Medical University. A stable alcoholism model was established through ad libitum feeding, and anti-alcohol drug treatment (Zhong Yao Jie Jiu Ling, the main ingredient was the stems of watermelon; developed in our laboratory), at low- and high-doses, was carried out. The Zhong Yao Jie Jiu Ling was effective for the alcoholism in dogs. The morphology of hippocampal neurons was evaluated using hematoxylin-eosin staining. The number and morphological features of BDNF, TrkB and p75NTR-positive neurons in the dentate gyrus (DG), and the CA1, CA3 and CA4 regions of the hippocampus were observed using immunohistochemistry. One-way ANOVA was used to determine differences in BDNF, TrkB and p75NTR expression. BDNF, TrkB and p75NTR-positive cells were mainly localized in the granular cell layer of the DG and in the pyramidal cell layer of the CA1, CA3 and CA4 regions (DG>CA1>CA3>CA4). Expression levels of both BDNF and TrkB were decreased in chronic alcoholism, and increased after abstinence. The CA4 region appeared to show the greatest differences. Changes in p75NTR expression were the opposite of those of BDNF and TrkB, with the greatest differences observed in the DG and CA4 regions.

  12. Affordable Development and Demonstration of a Small Nuclear Thermal Rocket (NTR) Engine and Stage: How Small Is Big Enough?

    Science.gov (United States)

    Borowski, Stanley K.; Sefcik, Robert J.; Fittje, James E.; McCurdy, David R.; Qualls, Arthur L.; Schnitzler, Bruce G.; Werner, James E.; Weitzberg, Abraham; Joyner, Claude R.

    2016-01-01

    The Nuclear Thermal Rocket (NTR) derives its energy from fission of uranium-235 atoms contained within fuel elements that comprise the engine's reactor core. It generates high thrust and has a specific impulse potential of approximately 900 specific impulse - a 100 percent increase over today's best chemical rockets. The Nuclear Thermal Propulsion (NTP) project, funded by NASA's Advanced Exploration Systems (AES) program, includes five key task activities: (1) Recapture, demonstration, and validation of heritage graphite composite (GC) fuel (selected as the Lead Fuel option); (2) Engine Conceptual Design; (3) Operating Requirements Definition; (4) Identification of Affordable Options for Ground Testing; and (5) Formulation of an Affordable Development Strategy. During fiscal year (FY) 2014, a preliminary Design Development Test and Evaluation (DDT&E) plan and schedule for NTP development was outlined by the NASA Glenn Research Center (GRC), Department of Energy (DOE) and industry that involved significant system-level demonstration projects that included Ground Technology Demonstration (GTD) tests at the Nevada National Security Site (NNSS), followed by a Flight Technology Demonstration (FTD) mission. To reduce cost for the GTD tests and FTD mission, small NTR engines, in either the 7.5 or 16.5 kilopound-force thrust class, were considered. Both engine options used GC fuel and a common fuel element (FE) design. The small approximately 7.5 kilopound-force criticality-limited engine produces approximately157 thermal megawatts and its core is configured with parallel rows of hexagonal-shaped FEs and tie tubes (TTs) with a FE to TT ratio of approximately 1:1. The larger approximately 16.5 kilopound-force Small Nuclear Rocket Engine (SNRE), developed by Los Alamos National Laboratory (LANL) at the end of the Rover program, produces approximately 367 thermal megawatts and has a FE to TT ratio of approximately 2:1. Although both engines use a common 35-inch (approximately

  13. Pilot Implementations

    DEFF Research Database (Denmark)

    Manikas, Maria Ie

    by conducting a literature review. The concept of pilot implementation, although commonly used in practice, is rather disregarded in research. In the literature, pilot implementations are mainly treated as secondary to the learning outcomes and are presented as merely a means to acquire knowledge about a given...... objective. The prevalent understanding is that pilot implementations are an ISD technique that extends prototyping from the lab and into test during real use. Another perception is that pilot implementations are a project multiple of co-existing enactments of the pilot implementation. From this perspective......This PhD dissertation engages in the study of pilot (system) implementation. In the field of information systems, pilot implementations are commissioned as a way to learn from real use of a pilot system with real data, by real users during an information systems development (ISD) project and before...

  14. Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE.

    Science.gov (United States)

    Yu, Yao; Wang, Jiadong; Yuan, Hanying; Qin, Feng; Wang, Jing; Zhang, Nailing; Li, Yu-Yang; Liu, Jianping; Lu, Hong

    2006-07-19

    Expression of human dopamine responsive gene-1 (DRG-1) is up-regulated in response to treatment of dopamine in the rat astrocytes. However, its functions are not clear up to now. In the presented studies, DRG-1 was identified to be a conserved gene in the vertebrate and expressed abundantly in human testis, brain and skeletal muscle. DRG-1 was shown to interact with human p75NTR-associated cell death executor (NADE) in vivo and in vitro, and the interaction occurred in cytoplasm. The regions required for the interaction were subsequently mapped to the N-terminal of DRG-1 and the C-terminal of NADE. Furthermore, MTT assay showed that stable expression of DRG-1 in 293 cells could promote cell proliferation, and this promotion was suppressed by overexpression of NADE. In flow cytometry cell cycle analysis, overexpression of DRG-1 in 293 or PC12 cells increased the population of cells in the S phase with a concomitant decrease in G0/G1 population. These findings suggest that DRG-1 may contribute to the dopamine-induced cell growth, which is negatively regulated by NADE.

  15. An analytical model of heat transfer and fluid dynamic performances of an unconventional NTR engine for manned interplanetary missions

    Energy Technology Data Exchange (ETDEWEB)

    Di Piazza, Ivan, E-mail: ivandipiazza@yahoo.i [Dipartimento di Ingegneria Nucleare, Universita degli studi di Palermo, Viale delle Scienze, Edificio 6, CAP 90128, Palermo (Italy)

    2009-12-15

    An analytical model of fluid flow and heat transfer of a Nuclear Thermal Rocket (NTR) engine concept is presented. The engine is based on the direct conversion of the kinetic energy of the fission fragments (FFs) into the propellant enthalpy. The FFs can escape from an extremely thin layer of fissionable material: a sufficiently large surface coated with few micrometers of Americium 242m, confined by a neutron moderator-reflector, may become a critical reactor. Three dimensional coupled CFD-Monte Carlo simulations have already been presented in . In this paper, an analytical integral 1-D model of fluid dynamics and heat transfer is built in order to foresee the performances on the basis of simple, physically founded correlations. The Peclet number has been identified as the main governing parameter of the system, and theoretically based correlations have been found for the thermodynamic efficiency of the engine and for the specific impulse. The correlations show a good agreement with numerical results presented in from fully coupled 3D CFD-Monte Carlo calculations.

  16. Involvement of TrkB- and p75NTR-signaling pathways in two contrasting forms of long-lasting synaptic plasticity

    Science.gov (United States)

    Sakuragi, Shigeo; Tominaga-Yoshino, Keiko; Ogura, Akihiko

    2013-11-01

    The repetition of experience is often necessary to establish long-lasting memory. However, the cellular mechanisms underlying this repetition-dependent consolidation of memory remain unclear. We previously observed in organotypic slice cultures of the rodent hippocampus that repeated inductions of long-term potentiation (LTP) led to a slowly developing long-lasting synaptic enhancement coupled with synaptogenesis. We also reported that repeated inductions of long-term depression (LTD) produced a long-lasting synaptic suppression coupled with synapse elimination. We proposed these phenomena as useful in vitro models for analyzing repetition-dependent consolidation. Here, we hypothesized that the enhancement and suppression are mediated by the brain-derived neurotrophic factor (BDNF)-TrkB signaling pathway and the proBDNF-p75NTR pathway, respectively. When we masked the respective pathways, reversals of the enhancement and suppression resulted. These results suggest the alternative activation of the p75NTR pathway by BDNF under TrkB-masking conditions and of the TrkB pathway by proBDNF under p75NTR-masking conditions, thus supporting the aforementioned hypothesis.

  17. PTL: A Propositional Typicality Logic

    CSIR Research Space (South Africa)

    Booth, R

    2012-09-01

    Full Text Available consequence relations first studied by Lehmann and col- leagues in the 90?s play a central role in nonmonotonic reasoning [13, 14]. This has been the case due to at least three main reasons. Firstly, they are based on semantic constructions that are elegant...) j ; 6j : ^ j PTL: A Propositional Typicality Logic 3 The semantics of (propositional) rational consequence is in terms of ranked models. These are partially ordered structures in which the ordering is modular. Definition 1. Given a set S...

  18. NSTAR Smart Grid Pilot

    Energy Technology Data Exchange (ETDEWEB)

    Rabari, Anil [NSTAR Electric, Manchester, NH (United States); Fadipe, Oloruntomi [NSTAR Electric, Manchester, NH (United States)

    2014-03-31

    NSTAR Electric & Gas Corporation (“the Company”, or “NSTAR”) developed and implemented a Smart Grid pilot program beginning in 2010 to demonstrate the viability of leveraging existing automated meter reading (“AMR”) deployments to provide much of the Smart Grid functionality of advanced metering infrastructure (“AMI”), but without the large capital investment that AMI rollouts typically entail. In particular, a central objective of the Smart Energy Pilot was to enable residential dynamic pricing (time-of-use “TOU” and critical peak rates and rebates) and two-way direct load control (“DLC”) by continually capturing AMR meter data transmissions and communicating through customer-sited broadband connections in conjunction with a standardsbased home area network (“HAN”). The pilot was supported by the U.S. Department of Energy’s (“DOE”) through the Smart Grid Demonstration program. NSTAR was very pleased to not only receive the funding support from DOE, but the guidance and support of the DOE throughout the pilot. NSTAR is also pleased to report to the DOE that it was able to execute and deliver a successful pilot on time and on budget. NSTAR looks for future opportunities to work with the DOE and others in future smart grid projects.

  19. Pilot implementation

    DEFF Research Database (Denmark)

    Hertzum, Morten; Bansler, Jørgen P.; Havn, Erling C.

    2012-01-01

    A recurrent problem in information-systems development (ISD) is that many design shortcomings are not detected during development, but first after the system has been delivered and implemented in its intended environment. Pilot implementations appear to promise a way to extend prototyping from...... the laboratory to the field, thereby allowing users to experience a system design under realistic conditions and developers to get feedback from realistic use while the design is still malleable. We characterize pilot implementation, contrast it with prototyping, propose a iveelement model of pilot...... implementation and provide three empirical illustrations of our model. We conclude that pilot implementation has much merit as an ISD technique when system performance is contingent on context. But we also warn developers that, despite their seductive conceptual simplicity, pilot implementations can be difficult...

  20. [NRH2 induces cell apoptosis of cerebral tissues around hematomas after intracerebral hemorrhage through up-regulating proNGF, sortilin and p75NTR expressions].

    Science.gov (United States)

    Zeng, Zhiqing; Liu, Hong; Jiang, Di

    2015-04-01

    To observe the expressions of neurotrophin receptor homolog 2 (NRH2), nerve growth factor precursor (proNGF), sortilin and neurotrophin receptor p75 (p75NTR) in cerebral tissues around hematomas in the different periods after intracerebral hemorrhage, and explore their relationships to cell apoptosis. The specimens of cerebral tissues around hematomas were collected from the patients undergoing hematoma removal operation after intracerebral hemorrhage. These specimens were divided into four groups, namely ≤ 6 hours, 6-24 hours(including 24 hours), 24-72 hours (including 72 hours) and over 72 hours according to the time from intracerebral hemorrhage to specimen collection. At the same time, 10 brain tissues distant to hemorrhage that dropped in the operative process were collected as a control group. Apoptosis index (AI) was examined in brain cells by terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labeling (TUNEL). The expressions of NRH2, proNGF, sortilin and p75NTR mRNAs and proteins in brain tissues were detected through real-time quantitative PCR and Western blotting, respectively. Also, the expressions of Bcl-2 and Bax in brain tissues were analyzed using Western blotting. In vitro cultured astrocytes of rat cortex were transfected by NRH2 siRNA or scramble siRNA. The expressions of proNGF, sortilin and p75NTR proteins were detected using Western blotting. AI was higher in all groups of hemorrhage for 6 hours or longer than that in control and ≤ 6 hours groups, and AI in the group of 24-72 hours after intracerebral hemorrhage was the highest. However, there was no significant difference in AI between ≤ 6 hours group and control group. With the extension of intracerebral hemorrhage time, the expression levels of proNGF and p75NTR mRNAs and proteins were gradually elevated, reached the peak in 24-72 hours, and maintained a higher level after 72 hours, whereas there were no significant differences in the above indicators

  1. Organotypic culture of normal, dysplastic and squamous cell carcinoma-derived oral cell lines reveals loss of spatial regulation of CD44 and p75 NTR in malignancy.

    Science.gov (United States)

    Dalley, Andrew J; AbdulMajeed, Ahmad A; Upton, Zee; Farah, Camile S

    2013-01-01

    Oral squamous cell carcinomas (OSCC) often arise from dysplastic lesions. The role of cancer stem cells in tumour initiation is widely accepted, yet the potential existence of pre-cancerous stem cells in dysplastic tissue has received little attention. Cell lines from oral diseases ranging in severity from dysplasia to malignancy provide opportunity to investigate the involvement of stem cells in malignant progression from dysplasia. Stem cells are functionally defined by their ability to generate hierarchical tissue structures in consortium with spatial regulation. Organotypic cultures readily display tissue hierarchy in vitro; hence, in this study, we compared hierarchical expression of stem cell-associated markers in dermis-based organotypic cultures of oral epithelial cells from normal tissue (OKF6-TERT2), mild dysplasia (DOK), severe dysplasia (POE-9n) and OSCC (PE/CA P J15). Expression of CD44, p75(NTR), CD24 and ALDH was studied in monolayers by flow cytometry and in organotypic cultures by immunohistochemistry. Spatial regulation of CD44 and p75(NTR) was evident for organotypic cultures of normal (OKF6-TERT2) and dysplasia (DOK and POE-9n) but was lacking for OSCC (PE/CA PJ15)-derived cells. Spatial regulation of CD24 was not evident. All monolayer cultures exhibited CD44, p75(NTR), CD24 antigens and ALDH activity (ALDEFLUOR(®) assay), with a trend towards loss of population heterogeneity that mirrored disease severity. In monolayer, increased FOXA1 and decreased FOXA2 expression correlated with disease severity, but OCT3/4, Sox2 and NANOG did not. We conclude that dermis-based organotypic cultures give opportunity to investigate the mechanisms that underlie loss of spatial regulation of stem cell markers seen with OSCC-derived cells. © 2012 John Wiley & Sons A/S.

  2. Localization of brain-derived neurotrophic factor, neurotrophin-4, tropomyosin-related kinase b receptor, and p75 NTR receptor by high-resolution immunohistochemistry on the adult mouse neuromuscular junction.

    Science.gov (United States)

    Garcia, Neus; Tomàs, Marta; Santafe, Manel M; Lanuza, M Angel; Besalduch, Nuria; Tomàs, Josep

    2010-03-01

    Neurotrophins and their receptors, the trk receptor tyrosine kinases (trks) and p75(NTR), are differentially expressed among the cell types that make up synapses. It is important to determine the precise location of these molecules involved in neurotransmission. Here we use immunostaining and Western blotting to study the localization and expression of neurotrophin brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) and the receptors tropomyosin-related kinase b (trkB) and p75(NTR) at the adult neuromuscular junction. Our confocal immunofluorescence results on the whole mounts of the mouse Levator auris longus muscle and on semithin cross-sections showed that BDNF, NT-4, trkB, and p75(NTR) were localized on the three cells in the neuromuscular synapse (motor axons, post-synaptic muscle and Schwann cells).

  3. The typical steps of radiation processes development. Experience in investigation, designing and application

    International Nuclear Information System (INIS)

    Babkin, I. Yu.

    1983-01-01

    The typical steps of radiation processes development are discussed as: primary laboratory investigations; primary economic evaluation; more exact estimation of situation in industry; comparative analysis; development of a flow sheet; pilot plant; obtaining of initial data for designing of industrial scale plant; prediction of industrial situation; designing of semi-industrial or industrial plant; industrial plant. (U.K.)

  4. Typicality and misinformation: Two sources of distortion

    Directory of Open Access Journals (Sweden)

    Malen Migueles

    2008-01-01

    Full Text Available This study examined the effect of two sources of memory error: exposure to post-event information and extracting typical contents from schemata. Participants were shown a video of a bank robbery and presented with highand low-typicality misinformation extracted from two normative studies. The misleading suggestions consisted of either changes in the original video information or additions of completely new contents. In the subsequent recognition task the post-event misinformation produced memory impairment. The participants used the underlying schema of the event to extract high-typicality information which had become integrated with episodic information, thus giving rise to more hits and false alarms for these items. However, the effect of exposure to misinformation was greater on low-typicality items. There were no differences between changed or added information, but there were more false alarms when a low-typicality item was changed to a high-typicality item

  5. Peptides derived from the solvent-exposed loops 3 and 4 of BDNF bind TrkB and p75(NTR) receptors and stimulate neurite outgrowth and survival

    DEFF Research Database (Denmark)

    Fobian, Kristina; Owczarek, Sylwia; Budtz, Christian

    2010-01-01

    Brain-derived neurotrophic factor (BDNF) is critically involved in modeling the developing nervous system and is an important regulator of a variety of crucial functions in the mature CNS. BDNF exerts its action through interactions with two transmembrane receptors, either separately or in concert....... BDNF has been implicated in several neurological disorders, and irregularities in BDNF function may have severe consequences. Administration of BDNF as a drug has thus far yielded few practicable results, and the potential side effects when using a multifunctional protein are substantial. In an effort...... to produce more specific compounds without side effects, small peptides mimicking protein function have been developed. The present study characterized two mimetic peptides, Betrofin 3 and Betrofin 4, derived from the BDNF sequence. Both Betrofins bound the cognate BDNF receptors, TrkB and p75(NTR...

  6. Expression and Significance of Stem Cell Markers CK19, Notch3, CD133, P75NTR, STRO-1 and ABCG2 in Pulmonary Squamous Carcinomas

    Directory of Open Access Journals (Sweden)

    Xuyong LIN, , , , ,

    2009-04-01

    Full Text Available Background and objective Increasing reports showed that some tumor stem cells were selfrenewal and multi-lineage differentiated in tumors, similar to the normal stem cells in human body. The aim of this study is to observe the expression of stem cell markers in lung squamous carcinoma tissues. Methods Fifty-four lung cancer specimens from surgery were analyzed for CK19, Notch3, CD133, P75NTR, STRO-1 and ABCG2 expression by using S-P immunohistochemistry. In addition, ten normal lung tissue samples were included as control. Results CK19, Notch3, CD133 and ABCG2 were expressed in 54 Lung cancer tissues, without expression of P75NTR and STRO-1. The expressionrate of CK19, Notch3, CD133 and ABCG2 was 66.67% (36/54, 87.04% (47/54, 50% (27/54, and 61.11% (33/54 respectively. The levels of expression of Notch3, CD133 and ABCG2 were significantly lower in high differentiation group than those in moderate and low differentiation group (P <0.05. The levels of expression of CK19, CD133 and ABCG2 were significantly higher in lymph node metastasis group than those in non-metastasis group (P <0.05. The percentage of total positive cells of four stem cell markers in serial tissue sections was lower than 2%. Conclusion There was expression ofsome stem cell markers in pulmonary squamous carcinomas, and there was relationship between expression degree withdifferentiation degree and lymph node metastasis.

  7. Pilot Greenhouse

    CERN Multimedia

    1983-01-01

    This pilot greenhouse was built in collaboration with the "Association des Maraichers" of Geneva in the frame of the study for making use of the heat rejected as warm water by CERN accelerators and experiments. Among other improvements, more automated and precise regulation systems for heating and ventilation were developed. See also 8305598X.

  8. [Injury patterns and typical stress situations in paragliding].

    Science.gov (United States)

    Bohnsack, M; Schröter, E

    2005-05-01

    Paragliding is known as a high risk sport with a substantial rate of severe and fatal injuries. Analysis of typical injury mechanisms and statistics showed that the total rate of paragliding injuries has decreased in recent years for an increasing number of pilots. In 2003, the rate of severe and fatal injuries in paragliding was less than that of other air sports and motorcycling. Through the introduction of a spine protector system in Germany and Austria, the number of vertebral fractures decreased significantly between 2000 and 2003. Most other injuries, especially of the lower extremities, could be avoided by adequate and farsighted flight behavior. Qualified instruction with regular training, standardized development of safety equipment and consequent analysis of paragliding injuries will help to improve the safety status in paragliding.

  9. A Typical Verification Challenge for the GRID

    NARCIS (Netherlands)

    van de Pol, Jan Cornelis; Bal, H. E.; Brim, L.; Leucker, M.

    2008-01-01

    A typical verification challenge for the GRID community is presented. The concrete challenge is to implement a simple recursive algorithm for finding the strongly connected components in a graph. The graph is typically stored in the collective memory of a number of computers, so a distributed

  10. Options for human ``return to the moon'' using tomorrow's SSTO, ISRU, and LOX-augmented NTR technologies

    Science.gov (United States)

    Borowski, Stanley K.

    1996-03-01

    The feasibility of conducting human missions to the Moon is examined assuming the use of three ``high leverage'' technologies: (1) a single-stage-to-orbit (SSTO) launch vehicle, (2) ``in-situ'' resource utilization (ISRU)—specifically ``lunar-derived'' liquid oxygen (LUNOX), and (3) LOX-augmented nuclear thermal rocket (LANTR) propulsion. Lunar transportation system elements consisting of a LANTR-powered lunar transfer vehicle (LTV) and a chemical propulsion lunar landing/Earth return vehicle (LERV) are configured to fit within the ``compact'' dimensions of the SSTO cargo bay (diameter: 4.6 m/length: 9.0 m) while satisfying an initial mass in low Earth orbit (IMLEO) limit of ˜60 t (3 SSTO launches). Using ˜8 t of LUNOX to ``reoxidize'' the LERV for a ``direct return'' flight to Earth reduces its size and mass allowing delivery to LEO on a single 20 t SSTO launch. Similarly, the LANTR engine's ability to operate at any oxygen/hydrogen mixture ratio from 0 to 7 with high specific impulse (˜940 to 515 s) is exploited to reduce hydrogen tank volume, thereby improving packaging of the LANTR LTV's ``propulsion'' and ``propellant modules''. Expendable and reusable, piloted and cargo missions and vehicle designs are presented along with estimates of LUNOX production required to support the different mission modes.

  11. The genome sequence of the protostome Daphnia pulex encodes respective orthologues of a neurotrophin, a Trk and a p75NTR: Evolution of neurotrophin signaling components and related proteins in the bilateria

    Directory of Open Access Journals (Sweden)

    Wilson Karen HS

    2009-10-01

    Full Text Available Abstract Background Neurotrophins and their Trk and p75NTR receptors play an important role in the nervous system. To date, neurotrophins, Trk and p75NTR have only been found concomitantly in deuterostomes. In protostomes, homologues to either neurotrophin, Trk or p75NTR are reported but their phylogenetic relationship to deuterostome neurotrophin signaling components is unclear. Drosophila has neurotrophin homologues called Spätzles (Spz, some of which were recently renamed neurotrophins, but direct proof that these are deuterostome neurotrophin orthologues is lacking. Trks belong to the receptor tyrosine kinase (RTK family and among RTKs, Trks and RORs are closest related. Flies lack Trks but have ROR and ROR-related proteins called NRKs playing a neurotrophic role. Mollusks have so far the most similar proteins to Trks (Lymnaea Trk and Aplysia Trkl but the exact phylogenetic relationship of mollusk Trks to each other and to vertebrate Trks is unknown. p75NTR belongs to the tumor necrosis factor receptor (TNFR superfamily. The divergence of the TNFR families in vertebrates has been suggested to parallel the emergence of the adaptive immune system. Only one TNFR representative, the Drosophila Wengen, has been found in protostomes. To clarify the evolution of neurotrophin signaling components in bilateria, this work analyzes the genome of the crustacean Daphnia pulex as well as new genetic data from protostomes. Results The Daphnia genome encodes a neurotrophin, p75NTR and Trk orthologue together with Trkl, ROR, and NRK-RTKs. Drosophila Spz1, 2, 3, 5, 6 orthologues as well as two new groups of Spz proteins (Spz7 and 8 are also found in the Daphnia genome. Searching genbank and the genomes of Capitella, Helobdella and Lottia reveals neurotrophin signaling components in other protostomes. Conclusion It appears that a neurotrophin, Trk and p75NTR existed at the protostome/deuterostome split. In protostomes, a "neurotrophin superfamily" includes

  12. Pilot study

    International Nuclear Information System (INIS)

    Hofmeester, G.H.; Swart, A.; Dijk, E. van

    1984-01-01

    In May 1980 it was decided to organize an intercomparison of personal dosimeters for photon radiations. The Commission of the European Communities initiated the intercomparison by starting a pilot study in which three laboratories NPL (United Kingdom), PTB (Germany) and RIV (The Netherlands) were asked to irradiate a series of personal dosemeters from institutes, GSF (Muenchen), CEA (Fontenay-aux-Roses), CNEN (Bologna) and CEGB (Berkeley). The latter institutes are secondary standard laboratories and have a radiation protection service as well. A new aspect of this pilot study is the fact that the irradiations also take place in front of a phantom. Irradiations took place in July and August 1980. The results of 4 institutes show that the personal dosemeters are quite capable of measuring the backscattered photon components

  13. Prediction and typicality in multiverse cosmology

    International Nuclear Information System (INIS)

    Azhar, Feraz

    2014-01-01

    In the absence of a fundamental theory that precisely predicts values for observable parameters, anthropic reasoning attempts to constrain probability distributions over those parameters in order to facilitate the extraction of testable predictions. The utility of this approach has been vigorously debated of late, particularly in light of theories that claim we live in a multiverse, where parameters may take differing values in regions lying outside our observable horizon. Within this cosmological framework, we investigate the efficacy of top-down anthropic reasoning based on the weak anthropic principle. We argue contrary to recent claims that it is not clear one can either dispense with notions of typicality altogether or presume typicality, in comparing resulting probability distributions with observations. We show in a concrete, top-down setting related to dark matter, that assumptions about typicality can dramatically affect predictions, thereby providing a guide to how errors in reasoning regarding typicality translate to errors in the assessment of predictive power. We conjecture that this dependence on typicality is an integral feature of anthropic reasoning in broader cosmological contexts, and argue in favour of the explicit inclusion of measures of typicality in schemes invoking anthropic reasoning, with a view to extracting predictions from multiverse scenarios. (paper)

  14. Prediction and typicality in multiverse cosmology

    Science.gov (United States)

    Azhar, Feraz

    2014-02-01

    In the absence of a fundamental theory that precisely predicts values for observable parameters, anthropic reasoning attempts to constrain probability distributions over those parameters in order to facilitate the extraction of testable predictions. The utility of this approach has been vigorously debated of late, particularly in light of theories that claim we live in a multiverse, where parameters may take differing values in regions lying outside our observable horizon. Within this cosmological framework, we investigate the efficacy of top-down anthropic reasoning based on the weak anthropic principle. We argue contrary to recent claims that it is not clear one can either dispense with notions of typicality altogether or presume typicality, in comparing resulting probability distributions with observations. We show in a concrete, top-down setting related to dark matter, that assumptions about typicality can dramatically affect predictions, thereby providing a guide to how errors in reasoning regarding typicality translate to errors in the assessment of predictive power. We conjecture that this dependence on typicality is an integral feature of anthropic reasoning in broader cosmological contexts, and argue in favour of the explicit inclusion of measures of typicality in schemes invoking anthropic reasoning, with a view to extracting predictions from multiverse scenarios.

  15. How typical are 'typical' tremor characteristics? : Sensitivity and specificity of five tremor phenomena

    NARCIS (Netherlands)

    van der Stouwe, A. M. M.; Elting, J. W.; van der Hoeven, J. H.; van Laar, T.; Leenders, K. L.; Maurits, N. M.; Tijssen, M. Aj.

    Introduction: Distinguishing between different tremor disorders can be challenging. Some tremor disorders are thought to have typical tremor characteristics: the current study aims to provide sensitivity and specificity for five 'typical' tremor phenomena. Methods: Retrospectively, we examined 210

  16. What is typical is good: The influence of face typicality on perceived trustworthiness

    NARCIS (Netherlands)

    Sofer, C.; Dotsch, R.; Wigboldus, D.H.J.; Todorov, A.T.

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality's influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness

  17. Typical horticultural products between tradition and innovation

    Directory of Open Access Journals (Sweden)

    Innocenza Chessa

    Full Text Available Recent EU and National policies for agriculture and rural development are mainly focused to foster the production of high quality products as a result of the increasing demand of food safety, typical foods and traditional processing methods. Another word very often used to describe foods in these days is “typicality” which pools together the concepts of “food connected with a specific place”, “historical memory and tradition” and “culture”. The importance for the EU and the National administrations of the above mentioned kind of food is demonstrated, among other things, by the high number of the PDO, PGI and TSG certificated products in Italy. In this period of global markets and economical crisis farmers are realizing how “typical products” can be an opportunity to maintain their market share and to improve the economy of local areas. At the same time, new tools and strategy are needed to reach these goals. A lack of knowledge has being recognized also on how new technologies and results coming from recent research can help in exploiting traditional product and in maintaining the biodiversity. Taking into account the great variety and richness of typical products, landscapes and biodiversity, this report will describe and analyze the relationships among typicality, innovation and research in horticulture. At the beginning “typicality” and “innovation” will be defined also through some statistical features, which ranks Italy at the first place in terms of number of typical labelled products, then will be highlighted how typical products of high quality and connected with the tradition and culture of specific production areas are in a strict relationship with the value of agro-biodiversity. Several different examples will be used to explain different successful methods and/or strategies used to exploit and foster typical Italian vegetables, fruits and flowers. Finally, as a conclusion, since it is thought that

  18. Identifying Typical Movements Among Indoor Objects

    DEFF Research Database (Denmark)

    Radaelli, Laura; Sabonis, Dovydas; Lu, Hua

    2013-01-01

    With the proliferation of mobile computing, positioning systems are becoming available that enable indoor location-based services. As a result, indoor tracking data is also becoming available. This paper puts focus on one use of such data, namely the identification of typical movement patterns...

  19. TYPICAL FORMS OF LIVER PATHOLOGY IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Peter F. Litvitskiy

    2018-01-01

    Full Text Available This lecture for the system of postgraduate medical education analyzes causes, types, key links of pathogenesis, and manifestations of the main typical forms of liver pathology — liver failure, hepatic coma, jaundice, cholemia, acholia, cholelithiasis, and their complications in children. To control the retention of the lecture material, case problems and multiple-choice tests are given.

  20. Typical electric bills, January 1, 1981

    International Nuclear Information System (INIS)

    1981-01-01

    The Typical Electric Bills report is prepared by the Electric Power Division; Office of Coal, Nuclear, Electric and Alternate Fuels; Energy Information Administration; Department of Energy. The publication is geared to a variety of applications by electric utilities, industry, consumes, educational institutions, and government in recognition of the growing importance of energy planning in contemporary society. 19 figs., 18 tabs

  1. Expression of the nifA gene of Herbaspirillum seropedicae: role of the NtrC and NifA binding sites and of the -24/-12 promoter element.

    Science.gov (United States)

    Souza, E M; Pedrosa, F O; Rigo, L U; Machado, H B; Yates, M G

    2000-06-01

    The nifA promoter of Herbaspirillum seropedicae contains potential NtrC, NifA and IHF binding sites together with a -12/-24 sigma(N)-dependent promoter. This region has now been investigated by deletion mutagenesis for the effect of NtrC and NifA on the expression of a nifA::lacZ fusion. A 5' end to the RNA was identified at position 641, 12 bp downstream from the -12/-24 promoter. Footprinting experiments showed that the G residues at positions -26 and -9 are hypermethylated, and that the region from -10 to +10 is partially melted under nitrogen-fixing conditions, confirming that this is the active nifA promoter. In H. seropedicae nifA expression from the sigma(N)-dependent promoter is repressed by fixed nitrogen but not by oxygen and is probably activated by the NtrC protein. NifA protein is apparently not essential for nifA expression but it can still bind the NifA upstream activating sequence.

  2. Herpes zoster - typical and atypical presentations.

    Science.gov (United States)

    Dayan, Roy Rafael; Peleg, Roni

    2017-08-01

    Varicella- zoster virus infection is an intriguing medical entity that involves many medical specialties including infectious diseases, immunology, dermatology, and neurology. It can affect patients from early childhood to old age. Its treatment requires expertise in pain management and psychological support. While varicella is caused by acute viremia, herpes zoster occurs after the dormant viral infection, involving the cranial nerve or sensory root ganglia, is re-activated and spreads orthodromically from the ganglion, via the sensory nerve root, to the innervated target tissue (skin, cornea, auditory canal, etc.). Typically, a single dermatome is involved, although two or three adjacent dermatomes may be affected. The lesions usually do not cross the midline. Herpes zoster can also present with unique or atypical clinical manifestations, such as glioma, zoster sine herpete and bilateral herpes zoster, which can be a challenging diagnosis even for experienced physicians. We discuss the epidemiology, pathophysiology, diagnosis and management of Herpes Zoster, typical and atypical presentations.

  3. Metabolic disorders with typical alterations in MRI

    International Nuclear Information System (INIS)

    Warmuth-Metz, M.

    2010-01-01

    The classification of metabolic disorders according to the etiology is not practical for neuroradiological purposes because the underlying defect does not uniformly transform into morphological characteristics. Therefore typical MR and clinical features of some easily identifiable metabolic disorders are presented. Canavan disease, Pelizaeus-Merzbacher disease, Alexander disease, X-chromosomal adrenoleukodystrophy and adrenomyeloneuropathy, mitochondrial disorders, such as MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) and Leigh syndrome as well as L-2-hydroxyglutaric aciduria are presented. (orig.) [de

  4. [Typical atrial flutter: Diagnosis and therapy].

    Science.gov (United States)

    Thomas, Dierk; Eckardt, Lars; Estner, Heidi L; Kuniss, Malte; Meyer, Christian; Neuberger, Hans-Ruprecht; Sommer, Philipp; Steven, Daniel; Voss, Frederik; Bonnemeier, Hendrik

    2016-03-01

    Typical, cavotricuspid-dependent atrial flutter is the most common atrial macroreentry tachycardia. The incidence of atrial flutter (typical and atypical forms) is age-dependent with 5/100,000 in patients less than 50 years and approximately 600/100,000 in subjects > 80 years of age. Concomitant heart failure or pulmonary disease further increases the risk of typical atrial flutter.Patients with atrial flutter may present with symptoms of palpitations, reduced exercise capacity, chest pain, or dyspnea. The risk of thromboembolism is probably similar to atrial fibrillation; therefore, the same antithrombotic prophylaxis is required in atrial flutter patients. Acutely symptomatic cases may be subjected to cardioversion or pharmacologic rate control to relieve symptoms. Catheter ablation of the cavotricuspid isthmus represents the primary choice in long-term therapy, associated with high procedural success (> 97 %) and low complication rates (0.5 %).This article represents the third part of a manuscript series designed to improve professional education in the field of cardiac electrophysiology. Mechanistic and clinical characteristics as well as management of isthmus-dependent atrial flutter are described in detail. Electrophysiological findings and catheter ablation of the arrhythmia are highlighted.

  5. What Is Typical Is Good : The Influence of Face Typicality on Perceived Trustworthiness

    NARCIS (Netherlands)

    Sofer, Carmel; Dotsch, Ron; Wigboldus, Daniel H J; Todorov, Alexander

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality’s influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness

  6. Group typicality, group loyalty and cognitive development.

    Science.gov (United States)

    Patterson, Meagan M

    2014-09-01

    Over the course of childhood, children's thinking about social groups changes in a variety of ways. Developmental Subjective Group Dynamics (DSGD) theory emphasizes children's understanding of the importance of conforming to group norms. Abrams et al.'s study, which uses DSGD theory as a framework, demonstrates the social cognitive skills underlying young elementary school children's thinking about group norms. Future research on children's thinking about groups and group norms should explore additional elements of this topic, including aspects of typicality beyond loyalty. © 2014 The British Psychological Society.

  7. Modelling object typicality in description logics

    CSIR Research Space (South Africa)

    Britz, K

    2009-12-01

    Full Text Available in the context under consideration, than those lower down. For any given class C, we assume that all objects in the appli- cation domain that are in (the interpretation of) C are more typical of C than those not in C. This is a technical construction which... to be modular partial orders, i.e. reflexive, transitive, anti- symmetric relations such that, for all a, b, c in ∆I , if a and b are incomparable and a is strictly below c, then b is also strictly below c. Modular partial orders have the effect...

  8. Benchmark calculation programme concerning typical LMFBR structures

    International Nuclear Information System (INIS)

    Donea, J.; Ferrari, G.; Grossetie, J.C.; Terzaghi, A.

    1982-01-01

    This programme, which is part of a comprehensive activity aimed at resolving difficulties encountered in using design procedures based on ASME Code Case N-47, should allow to get confidence in computer codes which are supposed to provide a realistic prediction of the LMFBR component behaviour. The calculations started on static analysis of typical structures made of non linear materials stressed by cyclic loads. The fluid structure interaction analysis is also being considered. Reasons and details of the different benchmark calculations are described, results obtained are commented and future computational exercise indicated

  9. Typical skeletal changes due to metastasising neuroblastomas

    International Nuclear Information System (INIS)

    Eggerath, A.; Persigehl, M.; Mertens, R.; Technische Hochschule Aachen

    1983-01-01

    Compared with other solid tumours in childhood, neuroblastomas show a marked tendency to metastasise to the skeleton. The differentiation of these lesions from inflammatory and other malignant bone lesions in this age group is often difficult. The radiological findings in ten patients with metastasing and histologically confirmed neuroblastomas have been reviewed and the typical appearances in the skeleton are described. The most important features in the differential diagnosies are discussed and the significance of bone changes in the diagnosis of neuroblastoma have been evaluated. (orig.) [de

  10. The Typicality Ranking Task: A New Method to Derive Typicality Judgments from Children

    Science.gov (United States)

    Ameel, Eef; Storms, Gert

    2016-01-01

    An alternative method for deriving typicality judgments, applicable in young children that are not familiar with numerical values yet, is introduced, allowing researchers to study gradedness at younger ages in concept development. Contrary to the long tradition of using rating-based procedures to derive typicality judgments, we propose a method that is based on typicality ranking rather than rating, in which items are gradually sorted according to their typicality, and that requires a minimum of linguistic knowledge. The validity of the method is investigated and the method is compared to the traditional typicality rating measurement in a large empirical study with eight different semantic concepts. The results show that the typicality ranking task can be used to assess children’s category knowledge and to evaluate how this knowledge evolves over time. Contrary to earlier held assumptions in studies on typicality in young children, our results also show that preference is not so much a confounding variable to be avoided, but that both variables are often significantly correlated in older children and even in adults. PMID:27322371

  11. 75 FR 56857 - Pilot, Flight Instructor, and Pilot School Certification

    Science.gov (United States)

    2010-09-17

    ...-2006-26661; Amendment No., 141-14] RIN 2120-AI86 Pilot, Flight Instructor, and Pilot School..., certification, and operating requirements for pilots, flight instructors, ground instructors, and pilot schools...: Background On August 21, 2009, the FAA published the ``Pilot, Flight Instructor, and Pilot School...

  12. Pilot Boarding Areas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Pilot boarding areas are locations at sea where pilots familiar with local waters board incoming vessels to navigate their passage to a destination port. Pilotage is...

  13. ONE TYPICAL EXTREMUM IN ELECTRICAL PROBLEMS

    Directory of Open Access Journals (Sweden)

    V. I. Goroshko

    2014-01-01

    Full Text Available The aim of this work is to attract attention of teachers, scientific personnel, engineers and students to one peculiarity of extremum seeking in different electrical problems. This feature lies in the fact that in many parts of electrical engineering extremum seeking comes to analysis one and the same mathematical structure (T-structure, but differences lie only in many symbols (designation.In one problems this structure appear in finale, the most simple form, but in others – T-structure is “veiled”, and as a rule  we need  elementary algebraic transformation to detect it.Taking into account high frequency of this structure appearing in electrical problems, in the first part of article the authors  carried out the investigation of extremum characteristics of T-structure and show the results in easy algorithms. To determine the typical T-structure there were taken five problems-examples for extremum seeking  from different parts of electrical engineering. The first and the second examples belong to the theory of electrical circuits.In the first example the problem of maximum active load power obtaining was considered, in the second we see the solution of problem for inductive coupled circuit adjustment in order to obtain the hump current. In the third example the band active filter, built on operating amplifier, is analyzed. According to these methods, taken in the first part of article, the frequency is determined, on which amplifier provides maximum  amplification factor. The forth example deals with analysis of efficiency of transformer. According to algorithm, the optimal efficiency of transformer’s load and also equation for its maximum was determined in this article. In the fifth example the mechanical characteristics of induction motor is analyzed. It is indicated how, on the basis of algorithms article, to obtain equations for critical slip and motor moment, and also the simple development of formula Klossa.The methods of

  14. Typical and atypical presentations of aspergilloma

    International Nuclear Information System (INIS)

    Villajos, M.; Darnell, A.; Gallardo, X.; Castaner, E.; Mata, J. M.; Paedavila, E.

    1999-01-01

    To show the different forms of radiological presentations of aspergilloma, emphasizing the importance of recognizing the atypical forms. The explorations of 11 patients with aspergilloma were examined retrospectively between 1993 and 1997. These patients were studied using conventional X-rays and computed tomography (CT): Typical and atypical radiological findings were observed. In two patients, who presented recurrent hemoptysis, a percutaneous installation of amphotericin B was carried out with tomographic control. Out of the 11 patients, two were female and nine male. In eight of the cases the radiological findings showed an intercavity injury with different evolutionary forms, while in three of the cases there was a progressive pleural swelling. In the two patients treated pertinaciously, no significant radiological changes were observed, however, neither of them showed hemoptysis again. The pleural swelling adjacent to the cavity and/or the swelling of the cavity wall are atypical radiological presentations of the aspergilloma, that can accompany or precede the appearance of this illness. (Author) 7 refs

  15. Idiopathic intracranial hypertension: A typical presentation

    International Nuclear Information System (INIS)

    Algahtani, Hussein A.; Obeid, Tahir H.; Abuzinadah, Ahmad R.; Baeesa, Saleh S.

    2007-01-01

    Objective was to describe the clinical features of 5 patients with rare atypical presentation of idiopathic intracranial hypertension (IIH), and propose the possible mechanism of this atypical presentation. We carried out a retrospective study of 5 patients, admitted at King Khalid National Guard Hospital, Jeddah, Kingdom of Saudi Arabia with IIH during the period from January 2001 to December 2005. All were females with their age ranges from 24 to 40 years. The clinical presentations, the laboratory and imaging studies were analyzed. The opening pressures of the lumbar puncture tests were documented. All patients were presented with headache. One had typical pain of trigeminal neuralgia and one with neck pain and radiculopathy. Facial diplegia was present in one patient and two patients had bilateral 6th cranial neuropathy. Papilledema was present in all patients except in one patient. Imaging study was normal in all patients, and they had a very high opening pressure during lumbar puncture, except in one patient. All patients achieved full recovery with medical therapy in 6 to 12 weeks with no relapse during the mean follow up of 2 years. Atypical finding in IIH are rare and require a high index of suspicion for early diagnosis. (author)

  16. Mathematics Placement Test: Typical Results with Unexpected Outcomes

    Science.gov (United States)

    Ingalls, Victoria

    2011-01-01

    Based on the results of a prior case-study analysis of mathematics placement at one university, the mathematics department developed and piloted a mathematics placement test. This article describes the implementation process for a mathematics placement test and further analyzes the test results for the pilot group. As an unexpected result, the…

  17. The ENIQ pilot study: current status

    Energy Technology Data Exchange (ETDEWEB)

    Lemaitre, P; Eriksen, B; Crutzen, S [European Commission, DG Joint Research Centre, Petten (Netherlands); Hansch, M [Preussische Elektrizitaets-AG (Preussenelektra), Hannover (Germany); Whittle, J [AEA Technology, Warrington (United Kingdom)

    1998-11-01

    A pilot study is currently being carried out by ENIQ (European Network for Inspection Qualification) in order to explore the issues involved in inspection qualification applied along the general principles of the European methodology. The components selected for the pilot study are austenitic pipe to pipe and pipe to elbows welds typical of those in BWR recirculation loops. A range of defect parameters has been defined. A suitable inspection procedure designed to find the designated defects will be applied to geometrically representative test pieces. The procedure/equipment will be qualified through open trials and technical justification. The personnel qualification will be done in a blind way. Once all features of the inspection system will have been qualified an in-service inspection will be simulated in order to test the feasibility of the qualification approach followed. In this paper the current status of this pilot study is discussed. (orig.)

  18. TYPICAL ABSENCES: RESULTS OF OWN INVESTIGATIONS

    Directory of Open Access Journals (Sweden)

    K. Yu. Mukhin

    2015-01-01

    Full Text Available Typical absences (TA are brief primary generalized epileptic seizures characterized by sudden onset and termination. According to their definition, absences consist of impairment of consciousness that is synchronously accompanied by electroencephalographic (EEG changes as generalized spike–slow wave discharges of 3 or more Hz. The authors conducted an investigation of 1261 patients with different forms of epilepsy with onset of seizures from the first days of life to the age of 18 years. The patients were followed up from 1990 to 2010. Absence seizures were detected in 231 patients, which accounts for 18.3 % of all the epileptic patients. TA were found in 102 patients, which constitutes 8.1 % of all cases of epilepsy with onset of seizures beyond the age of 18 years. The paper provides a detailed analysis of a group of patients with TA in terms of anamnestic, clinical, electroencephalographic, and neuroimaging features and the results of therapy with antiepileptic drugs (AEDs. The age of onset of TA-associated epilepsy was from 9 months to 17 years (mean 9.4 ± 4.06 years. The disease occurred most frequently in young school-age children (41.2 %. Isolated TA as the only type of seizures were observed in the clinical picture of 28 (27.5 % patients. TA were concurrent with other types of seizures in other cases. The investigators have identified 4 types of seizures which TA (generalized convulsions, myoclonic seizures, febrile seizures, and eyelid myoclonia may be concurrent with. Neuroimaging stated there were no brain changes in 85.3 % of TA-associated epilepsy cases. Moderate diffuse subatrophic changes were detected in other cases (14.7 %. Local cerebral structural abnormalities were absent. The use of antiepileptic therapy as both monotherapy and polytherapy using different combinations showed the high efficacy of AEDs. Complete remission was achieved in 84.3 % of TA-associated epilepsy cases. An AED-induced reduction in the frequency of

  19. Risperidone versus typical antipsychotic medication for schizophrenia.

    Science.gov (United States)

    Hunter, R H; Joy, C B; Kennedy, E; Gilbody, S M; Song, F

    2003-01-01

    found in long-term studies (n=859, 2RCTs RR not 20% improved 0.51 CI 0.38 to 0.67 NNT 4;n=675 1RCT, RR not improved 40% 0.75 CI 0.66 to 0.84 NNT 5; n=675, 1 RCT, RR not 60% improved 0.90 CI 0.84 to 0.96, NNT 11). Risperidone was also more likely to reduce relapse at one year follow up, compared with haloperidol (n=367, 1 RCT, RR 0.64 CI 0.41 to 0.99, NNT 7). Less people allocated risperidone left studies before completion, both for short-term (n=3066, 16 RCTs, RR 0.76 CI 0.63 to 0.92, NNT 6) and long-term trials (n=1270, 4RCTs, RR 0.55 CI 0.42 to 0.73 NNT 4). For general movement disorders results favoured risperidone. People given risperidone had significantly fewer general movement disorders (including extrapyramidal side effects) than those receiving older typical antipsychotics (n=2702, 10 RCTs, RR 0.63 CI 0.56 to 0.71, NNT 3). Significantly fewer people given risperidone used antiparkinsonian drugs (n=2524, 11 RCTs, RR 0.66 CI 0.58 to 0.74, NNT 4). As regards body weight, however, four studies (n=1708) found people were more likely to gain weight if allocated risperidone compared to typical antipsychotics (RR 1.55 CI 1.25 to 1.93, NNH 3). Risperidone was no more or less likely than haloperidol to cause sexual problems such as erectile dysfunction (n=106, 2 RCTs, RR 1.55 CI 0.58 to 4.20). Finally, some results found risperidone was more likely to cause rhinitis than conventional antipsychotics (n=656, 3 RCTs, RR1.99 CI 1.24 to 3.19, NNH 3). Risperidone may be more acceptable to those with schizophrenia than older antipsychotics and have marginal benefits in terms of limited clinical improvement. Its adverse effect profile may be better than haloperidol. With the addition of more studies to this review, the publication bias evident in previous versions is no longer a significant issue. Any marginal benefits this drug may have have to be balanced against its greater cost and increased tendency to cause side effects such as weight gain. Recent important longer term

  20. Crystallization and preliminary X-ray analysis of the ATPase domain of the σ(54)-dependent transcription activator NtrC1 from Aquifex aeolicus bound to the ATP analog ADP-BeFx.

    Science.gov (United States)

    Sysoeva, Tatyana A; Yennawar, Neela; Allaire, Marc; Nixon, B Tracy

    2013-12-01

    One way that bacteria regulate the transcription of specific genes to adapt to environmental challenges is to use different σ factors that direct the RNA polymerase holoenzyme to distinct promoters. Unlike σ(70) RNA polymerase (RNAP), σ(54) RNAP is unable to initiate transcription without an activator: enhancer-binding protein (EBP). All EBPs contain one ATPase domain that belongs to the family of ATPases associated with various cellular activities (AAA+ ATPases). AAA+ ATPases use the energy of ATP hydrolysis to remodel different target macromolecules to perform distinct functions. These mechanochemical enzymes are known to form ring-shaped oligomers whose conformations strongly depend upon nucleotide status. Here, the crystallization of the AAA+ ATPase domain of an EBP from Aquifex aeolicus, NtrC1, in the presence of the non-hydrolyzable ATP analog ADP-BeFx is reported. X-ray diffraction data were collected from two crystals from two different protein fractions of the NtrC1 ATPase domain. Previously, this domain was co-crystallized with ADP and ATP, but the latter crystals were grown from the Walker B substitution variant E239A. Therefore, the new data sets are the first for a wild-type EBP ATPase domain co-crystallized with an ATP analog and they reveal a new crystal form. The resulting structure(s) will shed light on the mechanism of EBP-type transcription activators.

  1. A protocol for a randomised controlled trial investigating the effect of increasing Omega-3 index with krill oil supplementation on learning, cognition, behaviour and visual processing in typically developing adolescents.

    Science.gov (United States)

    van der Wurff, I S M; von Schacky, C; Berge, K; Kirschner, P A; de Groot, R H M

    2016-07-08

    The influence of n-3 long-chain polyunsaturated fatty acids (LCPUFA) supplementation on brain functioning is debated. Some studies have found positive effects on cognition in children with learning difficulties, elderly people with cognitive impairment and depression scores in depressed individuals. Other studies have found null or negative effects. Observational studies in adolescents have found positive associations between fish consumption (containing n-3 LCPUFAs) and academic achievement. However, intervention studies in typically developing adolescents are missing. The goal of this study is to determine the influence of increasing Omega-3 Index on cognitive functioning, academic achievement and mental well-being of typically developing adolescents. Double-blind, randomised, placebo controlled intervention; 264 adolescents (age 13-15 years) attending lower general secondary education started daily supplementation of 400 mg eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) in cohort I (n=130) and 800 mg EPA+DHA in cohort II (n=134) or a placebo for 52 weeks. Recruitment took place according to a low Omega-3 Index (performed according to Good Clinical Practice. All data collected are linked to participant number only. The results will be disseminated on group level to participants and schools. The results will be presented at conferences and published in peer-reviewed journals. The study is approved by the Medical Ethical Committee of Atrium-Orbis-Zuyd Hospital and is registered at the Netherlands Trial Register (NTR4082). NTR4082 and NCT02240264; Pre-results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  2. Preparing Pilots for Takeoff

    Science.gov (United States)

    Ravage, Barbara

    2012-01-01

    Why would schools consider partnering with a vendor to operate a pilot? Why not just wait until the final product is released? For starters, pilots provide schools with a golden opportunity to get an early look at the software, take it for a test flight, and ask for changes tailored to their operating environment and business needs. In some cases,…

  3. Process evaluation of a tailored mobile health intervention aiming to reduce fatigue in airline pilots

    Directory of Open Access Journals (Sweden)

    Alwin van Drongelen

    2016-08-01

    four weeks or more. Fidelity was 67 %. The participants rated the intervention with a 6.4 (SD 1.6. Adherence was not associated with compliance, but was associated with satisfaction (p ≤ 0.001. Pilots of 35 to 45 year old were significantly more interested in advice regarding physical activity than their colleagues, and short-haul pilots were more interested in advice regarding nutrition compared to long-haul pilots. Conclusions The MORE Energy intervention was well received, resulting in an adequate reach and a high dose delivered. The compliance and satisfaction scores indicate that engagement and functionality should be enhanced, and the content and applicability of the advices should be improved to appeal all subgroups of the target population. Trial registration Nederlands Trial Register NTR2722 . Registered 27 January 2011.

  4. Process evaluation of a tailored mobile health intervention aiming to reduce fatigue in airline pilots.

    Science.gov (United States)

    van Drongelen, Alwin; Boot, Cécile R L; Hlobil, Hynek; Smid, Tjabe; van der Beek, Allard J

    2016-08-26

    participants rated the intervention with a 6.4 (SD 1.6). Adherence was not associated with compliance, but was associated with satisfaction (p ≤ 0.001). Pilots of 35 to 45 year old were significantly more interested in advice regarding physical activity than their colleagues, and short-haul pilots were more interested in advice regarding nutrition compared to long-haul pilots. The MORE Energy intervention was well received, resulting in an adequate reach and a high dose delivered. The compliance and satisfaction scores indicate that engagement and functionality should be enhanced, and the content and applicability of the advices should be improved to appeal all subgroups of the target population. Nederlands Trial Register NTR2722 . Registered 27 January 2011.

  5. Draft environmental assessment: Ocean Thermal Energy Conversion (OTEC) Pilot Plants

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, S.M.; Sands, M.D.; Donat, J.R.; Jepsen, P.; Smookler, M.; Villa, J.F.

    1981-02-01

    This Environmental Assessment (EA) has been prepared, in accordance with the National Environmental Policy Act of 1969, for the deployment and operation of a commercial 40-Megawatt (MW) Ocean Thermal Energy Conversion (OTEC) Pilot Plant (hereafter called the Pilot Plant). A description of the proposed action is presented, and a generic environment typical of the candidate Pilot Plant siting regions is described. An assessment of the potential environmental impacts associated with the proposed action is given, and the risk of credible accidents and mitigating measures to reduce these risks are considered. The Federal and State plans and policies the proposed action will encompass are described. Alternatives to the proposed action are presented. Appendix A presents the navigation and environmental information contained in the US Coast Pilot for each of the candidate sites; Appendix B provides a brief description of the methods and calculations used in the EA. It is concluded that environmental disturbances associated with Pilot Plant activities could potentially cause significant environmental impacts; however, the magnitude of these potential impacts cannot presently be assessed, due to insufficient engineering and environmental information. A site- and design-specific OTEC Pilot Plant Environmental Impact Statement (EIS) is required to resolve the potentially significant environmental effects associated with Pilot Plant deployment and operation. (WHK)

  6. Raising the profile of pilot and feasibility studies in relation to the development, evaluation and implementation of patient-reported outcome measures.

    OpenAIRE

    Jones, GL

    2017-01-01

    This editorial introduces a new special series on the pilot and feasibility testing of patient-reported outcome measures (PROMs) in the on-line open access journal Pilot and Feasibility Studies. Pilot and feasibility studies are typically implemented to address issues of uncertainty before undertaking a larger definitive study such as a randomised controlled trial or large scale survey. This editorial considers the role that such pilot and feasibility testing plays in relation to the developm...

  7. Pilot Weather Reports

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Aviation weather reports relayed from pilots to FAA air traffic controllers or National Weather Service personnel. Elements include sky cover, turbulence, wind...

  8. Agile Web Pilot Program

    National Research Council Canada - National Science Library

    Lang, Mark

    1997-01-01

    ... in an increasingly competitive global marketplace. The pilot program allowed 18 small and medium sized enterprises to experiment with new agile business practices in competitive manufacturing environments by forming virtual organizations within...

  9. CERN pilot greenhouse

    CERN Multimedia

    1983-01-01

    This pilot installation was situated near Bld. BA6 opposite to the main entrance of the Meyrin site, with respect to Route de Meyrin. See Weekly Bulletin 3/83, and also photo 8305594X, 8505898X, 8302200.

  10. Foods Inducing Typical Gastroesophageal Reflux Disease Symptoms in Korea

    OpenAIRE

    Choe, Jung Wan; Joo, Moon Kyung; Kim, Hyo Jung; Lee, Beom Jae; Kim, Ji Hoon; Yeon, Jong Eun; Park, Jong-Jae; Kim, Jae Seon; Byun, Kwan Soo; Bak, Young-Tae

    2017-01-01

    Background/Aims Several specific foods are known to precipitate gastroesophageal reflux disease (GERD) symptoms and GERD patients are usually advised to avoid such foods. However, foods consumed daily are quite variable according to regions, cultures, etc. This study was done to elucidate the food items which induce typical GERD symptoms in Korean patients. Methods One hundred and twenty-six Korean patients with weekly typical GERD symptoms were asked to mark all food items that induced typic...

  11. Concept typicality responses in the semantic memory network.

    Science.gov (United States)

    Santi, Andrea; Raposo, Ana; Frade, Sofia; Marques, J Frederico

    2016-12-01

    For decades concept typicality has been recognized as critical to structuring conceptual knowledge, but only recently has typicality been applied in better understanding the processes engaged by the neurological network underlying semantic memory. This previous work has focused on one region within the network - the Anterior Temporal Lobe (ATL). The ATL responds negatively to concept typicality (i.e., the more atypical the item, the greater the activation in the ATL). To better understand the role of typicality in the entire network, we ran an fMRI study using a category verification task in which concept typicality was manipulated parametrically. We argue that typicality is relevant to both amodal feature integration centers as well as category-specific regions. Both the Inferior Frontal Gyrus (IFG) and ATL demonstrated a negative correlation with typicality, whereas inferior parietal regions showed positive effects. We interpret this in light of functional theories of these regions. Interactions between category and typicality were not observed in regions classically recognized as category-specific, thus, providing an argument against category specific regions, at least with fMRI. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. 12 CFR 408.6 - Typical classes of action.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Typical classes of action. 408.6 Section 408.6 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES PROCEDURES FOR COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT Eximbank Implementing Procedures § 408.6 Typical classes of action. (a) Section 1507.3...

  13. DIRAC universal pilots

    Science.gov (United States)

    Stagni, F.; McNab, A.; Luzzi, C.; Krzemien, W.; Consortium, DIRAC

    2017-10-01

    In the last few years, new types of computing models, such as IAAS (Infrastructure as a Service) and IAAC (Infrastructure as a Client), gained popularity. New resources may come as part of pledged resources, while others are in the form of opportunistic ones. Most but not all of these new infrastructures are based on virtualization techniques. In addition, some of them, present opportunities for multi-processor computing slots to the users. Virtual Organizations are therefore facing heterogeneity of the available resources and the use of an Interware software like DIRAC to provide the transparent, uniform interface has become essential. The transparent access to the underlying resources is realized by implementing the pilot model. DIRAC’s newest generation of generic pilots (the so-called Pilots 2.0) are the “pilots for all the skies”, and have been successfully released in production more than a year ago. They use a plugin mechanism that makes them easily adaptable. Pilots 2.0 have been used for fetching and running jobs on every type of resource, being it a Worker Node (WN) behind a CREAM/ARC/HTCondor/DIRAC Computing element, a Virtual Machine running on IaaC infrastructures like Vac or BOINC, on IaaS cloud resources managed by Vcycle, the LHCb High Level Trigger farm nodes, and any type of opportunistic computing resource. Make a machine a “Pilot Machine”, and all diversities between them will disappear. This contribution describes how pilots are made suitable for different resources, and the recent steps taken towards a fully unified framework, including monitoring. Also, the cases of multi-processor computing slots either on real or virtual machines, with the whole node or a partition of it, is discussed.

  14. PULSE Pilot Certification Results

    Directory of Open Access Journals (Sweden)

    Pamela Pape-Lindstrom

    2015-08-01

    Full Text Available The pilot certification process is an ambitious, nationwide endeavor designed to motivate important changes in life sciences education that are in line with the recommendations of the 2011 Vision and Change Report: A Call to Action (American Association for the Advancement of Science [AAAS], 2011.  It is the goal of the certification process to acknowledge departments that have progressed towards full implementation of the tenets of Vision and Change and to motivate departments that have not begun to adopt the recommendations to consider doing so.  More than 70 life science departments applied to be part of the pilot certification process, funded by a National Science Foundation grant, and eight were selected based on initial evidence of transformed and innovative educational practices.  The programs chosen represent a wide variety of schools, including two-year colleges, liberal-arts institutions, regional comprehensive colleges, research universities and minority serving institutions.  Outcomes from this pilot were released June 1, 2015 (www.pulsecommunity.org, with all eight programs being recognized as having progressed along a continuum of change.  Five levels of achievement were defined as PULSE Pilot Progression Levels.  Of the eight departments in the pilot, one achieved “PULSE Progression Level III: Accomplished”.  Six departments achieved “PULSE Progression Level II: Developing” and one pilot department achieved “PULSE Progression Level I: Beginning”.  All of the schools have made significant movement towards the recommendations of Vision and Change relative to a traditional life sciences curriculum.  Overall, the response from the eight pilot schools has been positive. 

  15. Linking the Pilot Structural Model and Pilot Workload

    Science.gov (United States)

    Bachelder, Edward; Hess, Ronald; Aponso, Bimal; Godfroy-Cooper, Martine

    2018-01-01

    Behavioral models are developed that closely reproduced pulsive control response of two pilots using markedly different control techniques while conducting a tracking task. An intriguing find was that the pilots appeared to: 1) produce a continuous, internally-generated stick signal that they integrated in time; 2) integrate the actual stick position; and 3) compare the two integrations to either issue or cease a pulse command. This suggests that the pilots utilized kinesthetic feedback in order to sense and integrate stick position, supporting the hypothesis that pilots can access and employ the proprioceptive inner feedback loop proposed by Hess's pilot Structural Model. A Pilot Cost Index was developed, whose elements include estimated workload, performance, and the degree to which the pilot employs kinesthetic feedback. Preliminary results suggest that a pilot's operating point (parameter values) may be based on control style and index minimization.

  16. 76 FR 54095 - Pilot in Command Proficiency Check and Other Changes to the Pilot and Pilot School Certification...

    Science.gov (United States)

    2011-08-31

    ... [Docket No.: FAA-2008-0938; Amendment Nos. 61-128, 91-324, 141-15, and 142-7] RIN 2120-AJ18 Pilot in Command Proficiency Check and Other Changes to the Pilot and Pilot School Certification Rules AGENCY... regulations concerning pilot, flight instructor, and pilot school certification. This rule will require pilot...

  17. Narrative versus style: Effect of genre-typical events versus genre-typical filmic realizations on film viewers’ genre recognition

    NARCIS (Netherlands)

    Visch, V.; Tan, E.

    2008-01-01

    This study investigated whether film viewers recognize four basic genres (comic, drama, action and nonfiction) on the basis of genre-typical event cues or of genre-typical filmic realization cues of events. Event cues are similar to the narrative content of a film sequence, while filmic realization

  18. Generation of typical meteorological year for different climates of China

    International Nuclear Information System (INIS)

    Jiang, Yingni

    2010-01-01

    Accurate prediction of building energy performance requires precise information of the local climate. Typical weather year files like typical meteorological year (TMY) are commonly used in building simulation. They are also essential for numerical analysis of sustainable and renewable energy systems. The present paper presents the generation of typical meteorological year (TMY) for eight typical cities representing the major climate zones of China. The data set, which includes global solar radiation data and other meteorological parameters referring to dry bulb temperature, relative humidity, wind speed, has been analyzed. The typical meteorological year is generated from the available meteorological data recorded during the period 1995-2004, using the Finkelstein-Schafer statistical method. The cumulative distribution function (CDF) for each year is compared with the CDF for the long-term composite of all the years in the period. Typical months for each of the 12 calendar months from the period of years are selected by choosing the one with the smallest deviation from the long-term CDF. The 12 typical months selected from the different years are used for the formulation of a TMY.

  19. User Participation in Pilot Implementation

    DEFF Research Database (Denmark)

    Torkilsheyggi, Arnvør Martinsdóttir á; Hertzum, Morten

    2014-01-01

    Pilot implementations provide users with real-work experiences of how a system will affect their daily work before the design of the system is finalized. On the basis of a pilot implementation of a system for coordinating the transport of patients by hospital porters, we investigate pilot...... implementation as a method for participatory design. We find that to foster participation and learning about user needs a pilot implementation must create a space for reflecting on use, in addition to the space for using the pilot system. The space for reflection must also exist during the activities preparing...... the use of the pilot system because the porters and nurses learned about their needs throughout the pilot implementation, not just during use. Finally, we discuss how the scope and duration of a pilot implementation influence the conditions for participation....

  20. Neurofeedback as a treatment for major depressive disorder--a pilot study.

    Science.gov (United States)

    Peeters, Frenk; Oehlen, Mare; Ronner, Jacco; van Os, Jim; Lousberg, Richel

    2014-01-01

    There is growing interest in neurofeedback as a treatment for major depressive disorder. Reduction of asymmetry of alpha-activity between left and right prefrontal areas with neurofeedback has been postulated as effective in earlier studies. Unfortunately, methodological shortcomings limit conclusions that can be drawn from these studies. In a pilot-study, we investigated the effectiveness of reduction of asymmetry of alpha-activity with neurofeedback in depressed participants with the use of a stringent methodological approach. Nine participants meeting DSM-IV criteria for major depressive disorder were treated with a maximum of 30 neurofeedback-sessions, aimed at reducing asymmetry of alpha-activity, over a 10-week period. No changes in the use of antidepressants were allowed 6 weeks before and during the intervention. Changes in depressive symptomatology were assessed with the Quick Inventory of Depressive Symptoms, self-report version. We observed response in 1 and remission in 4 out of a total of 9 participants. The effectiveness appeared largest in female participants. The mean asymmetry of alpha-activity decreased significantly over sessions in a quadratic fashion. This decrease was associated with clinical response. This pilot study suggests that neurofeedback aimed at a reduction of frontal asymmetry of alpha-activity may be effective as a treatment for depression. However, this was an open label pilot study. Non-specific effects of the procedure and/or a beneficial natural course may have confounded the results. Randomized controlled trials will have to establish the efficacy of neurofeedback for depression. Nederlands Trial Register NTR1629.

  1. South American Youth and Integration : Typical Situations and Youth ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    South American Youth and Integration : Typical Situations and Youth ... IDRC partner the World Economic Forum is building a hub for inclusive growth ... Brazil, Paraguay and Uruguay) and their perception of rights, democracy and regional.

  2. 14 CFR 61.73 - Military pilots or former military pilots: Special rules.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Military pilots or former military pilots... Ratings and Pilot Authorizations § 61.73 Military pilots or former military pilots: Special rules. (a... a disciplinary action involving aircraft operations, a U.S. military pilot or former military pilot...

  3. Pilot project as enabler?

    DEFF Research Database (Denmark)

    Neisig, Margit; Glimø, Helle; Holm, Catrine Granzow

    This article deals with a systemic perspective on transition. The field of study addressed is a pilot project as enabler of transition in a highly complex polycentric context. From a Luhmannian systemic approach, a framework is created to understand and address barriers of change occurred using...... pilot projects as enabler of transition. Aspects of how to create trust and deal with distrust during a transition are addressed. The transition in focus is the concept of New Public Management and how it is applied in the management of the Employment Service in Denmark. The transition regards...

  4. Portion distortion: typical portion sizes selected by young adults.

    Science.gov (United States)

    Schwartz, Jaime; Byrd-Bredbenner, Carol

    2006-09-01

    The incidence of obesity has increased in parallel with increasing portion sizes of individually packaged and ready-to-eat prepared foods as well as foods served at restaurants. Portion distortion (perceiving large portion sizes as appropriate amounts to eat at a single eating occasion) may contribute to increasing energy intakes and expanding waistlines. The purpose of this study was to determine typical portion sizes that young adults select, how typical portion sizes compare with reference portion sizes (based in this study on the Nutrition Labeling and Education Act's quantities of food customarily eaten per eating occasion), and whether the size of typical portions has changed over time. Young adults (n=177, 75% female, age range 16 to 26 years) at a major northeastern university. Participants served themselves typical portion sizes of eight foods at breakfast (n=63) or six foods at lunch or dinner (n=62, n=52, respectively). Typical portion-size selections were unobtrusively weighed. A unit score was calculated by awarding 1 point for each food with a typical portion size that was within 25% larger or smaller than the reference portion; larger or smaller portions were given 0 points. Thus, each participant's unit score could range from 0 to 8 at breakfast or 0 to 6 at lunch and dinner. Analysis of variance or t tests were used to determine whether typical and reference portion sizes differed, and whether typical portion sizes changed over time. Mean unit scores (+/-standard deviation) were 3.63+/-1.27 and 1.89+/-1.14, for breakfast and lunch/dinner, respectively, indicating little agreement between typical and reference portion sizes. Typical portions sizes in this study tended to be significantly different from those selected by young adults in a similar study conducted 2 decades ago. Portion distortion seems to affect the portion sizes selected by young adults for some foods. This phenomenon has the potential to hinder weight loss, weight maintenance, and

  5. Single-Pilot Workload Management

    Science.gov (United States)

    Rogers, Jason; Williams, Kevin; Hackworth, Carla; Burian, Barbara; Pruchnicki, Shawn; Christopher, Bonny; Drechsler, Gena; Silverman, Evan; Runnels, Barry; Mead, Andy

    2013-01-01

    Integrated glass cockpit systems place a heavy cognitive load on pilots (Burian Dismukes, 2007). Researchers from the NASA Ames Flight Cognition Lab and the FAA Flight Deck Human Factors Lab examined task and workload management by single pilots. This poster describes pilot performance regarding programming a reroute while at cruise and meeting a waypoint crossing restriction on the initial descent.

  6. Pilot pulsar surveys with LOFAR

    NARCIS (Netherlands)

    Coenen, T.

    2013-01-01

    We are performing two complementary pilot pulsar surveys as part of LOFAR commissioning. The LOFAR Pilot Pulsar Survey (LPPS) is a shallow all-sky survey using an incoherent combination of LOFAR stations. The LOFAR Tied-Array Survey (LOTAS) is a deeper pilot survey using 19 simultaneous tied-array

  7. Effects of stress typicality during speeded grammatical classification.

    Science.gov (United States)

    Arciuli, Joanne; Cupples, Linda

    2003-01-01

    The experiments reported here were designed to investigate the influence of stress typicality during speeded grammatical classification of disyllabic English words by native and non-native speakers. Trochaic nouns and iambic gram verbs were considered to be typically stressed, whereas iambic nouns and trochaic verbs were considered to be atypically stressed. Experiments 1a and 2a showed that while native speakers classified typically stressed words individual more quickly and more accurately than atypically stressed words during differences reading, there were no overall effects during classification of spoken stimuli. However, a subgroup of native speakers with high error rates did show a significant effect during classification of spoken stimuli. Experiments 1b and 2b showed that non-native speakers classified typically stressed words more quickly and more accurately than atypically stressed words during reading. Typically stressed words were classified more accurately than atypically stressed words when the stimuli were spoken. Importantly, there was a significant relationship between error rates, vocabulary size and the size of the stress typicality effect in each experiment. We conclude that participants use information about lexical stress to help them distinguish between disyllabic nouns and verbs during speeded grammatical classification. This is especially so for individuals with a limited vocabulary who lack other knowledge (e.g., semantic knowledge) about the differences between these grammatical categories.

  8. Toddlers' categorization of typical and scrambled dolls and cars.

    Science.gov (United States)

    Heron, Michelle; Slaughter, Virginia

    2008-09-01

    Previous research has demonstrated discrimination of scrambled from typical human body shapes at 15-18 months of age [Slaughter, V., & Heron, M. (2004). Origins and early development of human body knowledge. Monographs of the Society for Research in Child Development, 69]. In the current study 18-, 24- and 30-month-old infants were presented with four typical and four scrambled dolls in a sequential touching procedure, to assess the development of explicit categorization of human body shapes. Infants were also presented with typical and scrambled cars, allowing comparison of infants' categorization of scrambled and typical exemplars in a different domain. Spontaneous comments regarding category membership were recorded. Girls categorized dolls and cars as typical or scrambled at 30 months, whereas boys only categorized the cars. Earliest categorization was for typical and scrambled cars, at 24 months, but only for boys. Language-based knowledge, coded from infants' comments, followed the same pattern. This suggests that human body knowledge does not have privileged status in infancy. Gender differences in performance are discussed.

  9. PILOT DECONTAMINATION THROUGH PILOT SEQUENCE HOPPING IN MASSIVE MIMO SYSTEMS

    DEFF Research Database (Denmark)

    2015-01-01

    path between one of the users and one of the base stations define one of the channels. The system comprises a pilot generation unit configured to assign pilot sequences randomly among the users and a pilot processing unit configured to filter the pilot sequences received from a user of interest so...... that the channel coefficient of the channel of the user of interest is determined. The pilot sequences received from the user of interest are contaminated by other non-orthogonal or identical pilot sequences from other users of the cell of interest or other cells. The filter is configured so that the contamination...... caused by the other non-orthogonal or identical pilot sequences from the other users is reduced....

  10. Evaluatie pilot Financieringslink

    NARCIS (Netherlands)

    Rosenboom, N.; Rougoor, W.; Fijnje, J.; Biesenbeek, C.

    Veel mkb-ondernemers hebben moeite om financiering te krijgen. Daarom heeft het ministerie van Economische Zaken in 2015 de pilot Financieringslink (Fink) opgezet– een online portal waar het mkb een financieringsverkenning kan indienen. Het hoofddoel van Fink is het verbeteren, standaardiseren en

  11. The Epoch Pilot Program.

    Science.gov (United States)

    Uhlenberg, Donald M.; Molenaar, Richard A.

    1982-01-01

    Describes a program for high school students who are between their junior and senior years which provides an opportunity to take part in aviation courses at the University of North Dakota. Students take courses leading to a private pilot license, and earn college credit for their efforts. (JN)

  12. Evaluatie pilot Endogene Factoren

    NARCIS (Netherlands)

    Viet AL; Fiolet D; Voortman JK; Rover C de; Hanning C; Uitenbroek D; Loon AJM van; PZO; GGD Achterhoek; GGD Midden Holland; GG&GD Amsterdam

    2004-01-01

    As a part of the project on the Local and National Monitor for Public Health several pilot studies were carried out in three Municipal Health Centres (GGDs). The first aim was to investigate the feasibility of a physical examination at the health centre in combination with a health interview (or

  13. Food and Wine Tourism: an Analysis of Italian Typical Products

    Directory of Open Access Journals (Sweden)

    Francesco Maria Olivieri

    2015-06-01

    Full Text Available The aim of this work is to focus the specific role of local food productions in spite of its relationship with tourism sector to valorization and promotion of the territorial cultural heritage. The modern agriculture has been and, in the recent years, several specific features are emerging referring to different territorials areas. Tourist would like to have a complete experience consumption of a destination, specifically to natural and cultural heritage and genuine food. This contribute addresses the topics connected to the relationship between typical productions system and tourism sector to underline the competitive advantages to local development. The typical productions are Designation of Protected Origin (Italian DOP, within wine certifications DOCG and DOC and Typical Geographical Indication (IGP and wine’s IGT. The aim is an analysis of the specialization of these kinds of production at Italian regional scale. The implication of the work has connected with defining a necessary and appropriate value strategies based on marketing principles in order to translate the benefit of typical productions to additional value for the local system. Thus, the final part of the paper describes the potential dynamics with the suitable accommodation typology of agriturismo and the typical production system of Italian Administrative Regions.

  14. Early Freezing of Gait: Atypical versus Typical Parkinson Disorders

    Directory of Open Access Journals (Sweden)

    Abraham Lieberman

    2015-01-01

    Full Text Available In 18 months, 850 patients were referred to Muhammad Ali Parkinson Center (MAPC. Among them, 810 patients had typical Parkinson disease (PD and 212 had PD for ≤5 years. Among the 212 patients with early PD, 27 (12.7% had freezing of gait (FOG. Forty of the 850 had atypical parkinsonism. Among these 40 patients, all of whom had symptoms for ≤5 years, 12 (30.0% had FOG. FOG improved with levodopa in 21/27 patients with typical PD but did not improve in the 12 patients with atypical parkinsonism. FOG was associated with falls in both groups of patients. We believe that FOG unresponsive to levodopa in typical PD resembles FOG in atypical parkinsonism. We thus compared the 6 typical PD patients with FOG unresponsive to levodopa plus the 12 patients with atypical parkinsonism with the 21 patients with typical PD responsive to levodopa. We compared them by tests of locomotion and postural stability. Among the patients with FOG unresponsive to levodopa, postural stability was more impaired than locomotion. This finding leads us to believe that, in these patients, postural stability, not locomotion, is the principal problem underlying FOG.

  15. Generation of a typical meteorological year for Hong Kong

    International Nuclear Information System (INIS)

    Chan, Apple L.S.; Chow, T.T.; Fong, Square K.F.; Lin, John Z.

    2006-01-01

    Weather data can vary significantly from year to year. There is a need to derive typical meteorological year (TMY) data to represent the long-term typical weather condition over a year, which is one of the crucial factors for successful building energy simulation. In this paper, various types of typical weather data sets including the TMY, TMY2, WYEC, WYEC2, WYEC2W, WYEC2T and IWEC were reviewed. The Finkelstein-Schafer statistical method was applied to analyze the hourly measured weather data of a 25-year period (1979-2003) in Hong Kong and select representative typical meteorological months (TMMs). The cumulative distribution function (CDF) for each year was compared with the CDF for the long-term composite of all the years in the period for four major weather indices including dry bulb temperature, dew point temperature, wind speed and solar radiation. Typical months for each of the 12 calendar months from the period of years were selected by choosing the one with the smallest deviation from the long-term CDF. The 12 TMMs selected from the different years were used for formulation of a TMY for Hong Kong

  16. Flight Bags as a Cause of Back Injuries Among Commercial Pilots.

    Science.gov (United States)

    Kanumuri, Vamsi S R; Zautke, John L; Dorevitch, Samuel

    2015-06-01

    Pilots of fixed wing commercial aircraft face numerous occupational hazards. Low back pain is among the most common and costly workplace injury, though relatively little is known about causes of back injuries among pilots. The awkward lifting and twisting maneuvers in the flight deck to position flight bags has not been described as a cause of occupational back injury among pilots. A case series of low back injuries among pilots was identified and described by a retrospective review of charts at an airport-based clinic. Circumstances of occupational back injury, initial direct medical costs, treatment, and work status following evaluation were described. Over a 6-yr period, 37 occupational low back injuries among 35 pilots were evaluated and treated. Of these, 24 (65%) involved flight bags. Only 27% of pilots with flight bag-associated injuries were returned to work after initial evaluation; medications with sedating properties were frequently required for treatment. Injuries due to slips, trips, and falls, typically in jet bridges or associated with hotel shuttles, were common among pilots with back injuries not related to flight bags. The majority of occupational low back injuries seen among pilots in an airport based clinic were attributable to use of flight bags. Substituting electronic flight bags for traditional flight bags could contribute to back injury prevention among pilots.

  17. Spatial Resolution of the ECE for JET Typical Parameters

    International Nuclear Information System (INIS)

    Tribaldos, V.

    2000-01-01

    The purpose of this report is to obtain estimations of the spatial resolution of the electron cyclotron emission (ECE) phenomena for the typical plasmas found in JET tokamak. The analysis of the spatial resolution of the ECE is based on the underlying physical process of emission and a working definition is presented and discussed. In making these estimations a typical JET pulse is being analysed taking into account the magnetic configuration, the density and temperature profiles, obtained with the EFIT code and from the LIDAR diagnostic. Ray tracing simulations are performed for a Maxwellian plasma taking into account the antenna pattern. (Author) 5 refs

  18. Typicality effects in artificial categories: is there a hemisphere difference?

    Science.gov (United States)

    Richards, L G; Chiarello, C

    1990-07-01

    In category classification tasks, typicality effects are usually found: accuracy and reaction time depend upon distance from a prototype. In this study, subjects learned either verbal or nonverbal dot pattern categories, followed by a lateralized classification task. Comparable typicality effects were found in both reaction time and accuracy across visual fields for both verbal and nonverbal categories. Both hemispheres appeared to use a similarity-to-prototype matching strategy in classification. This indicates that merely having a verbal label does not differentiate classification in the two hemispheres.

  19. Determination of illuminants representing typical white light emitting diodes sources

    DEFF Research Database (Denmark)

    Jost, S.; Ngo, M.; Ferrero, A.

    2017-01-01

    is to develop LED-based illuminants that describe typical white LED products based on their Spectral Power Distributions (SPDs). Some of these new illuminants will be recommended in the update of the CIE publication 15 on colorimetry with the other typical illuminants, and among them, some could be used......Solid-state lighting (SSL) products are already in use by consumers and are rapidly gaining the lighting market. Especially, white Light Emitting Diode (LED) sources are replacing banned incandescent lamps and other lighting technologies in most general lighting applications. The aim of this work...... to complement the CIE standard illuminant A for calibration use in photometry....

  20. Influence of Coupled Sidesticks on the Pilot Monitoring's Awareness During Flare

    OpenAIRE

    Uehara, Alan F.; Niedermeier, Dominik

    2015-01-01

    Passive sidesticks have been used in modern fly-by-wire commercial airplanes since the late 1980s. These passive sidesticks typically do not feature a mechanical coupling between them, so the pilot’s and copilot’s sidesticks move independently. This characteristic disabled the pilot monitoring (PM) to perceive the control inputs of the pilot flying (PF). This can lead to problems of awareness in abnormal situations. The development of active inceptor technology made it possible to electronicall...

  1. 76 FR 63183 - Pilot in Command Proficiency Check and Other Changes to the Pilot and Pilot School Certification...

    Science.gov (United States)

    2011-10-12

    ...-0938; Amendment Nos. 61-128, 91-324, 141-15, and 142-7] RIN 2120-AJ18 Pilot in Command Proficiency Check and Other Changes to the Pilot and Pilot School Certification Rules; Correction AGENCY: Federal... regulations to revise the pilot, flight instructor, and pilot school certification requirements. In particular...

  2. Pilot Critical Incident Reports as a Means to Identify Human Factors of Remotely Piloted Aircraft

    Science.gov (United States)

    Hobbs, Alan; Cardoza, Colleen; Null, Cynthia

    2016-01-01

    It has been estimated that aviation accidents are typically preceded by numerous minor incidents arising from the same causal factors that ultimately produced the accident. Accident databases provide in-depth information on a relatively small number of occurrences, however incident databases have the potential to provide insights into the human factors of Remotely Piloted Aircraft System (RPAS) operations based on a larger volume of less-detailed reports. Currently, there is a lack of incident data dealing with the human factors of unmanned aircraft systems. An exploratory study is being conducted to examine the feasibility of collecting voluntary critical incident reports from RPAS pilots. Twenty-three experienced RPAS pilots volunteered to participate in focus groups in which they described critical incidents from their own experience. Participants were asked to recall (1) incidents that revealed a system flaw, or (2) highlighted a case where the human operator contributed to system resilience or mission success. Participants were asked to only report incidents that could be included in a public document. During each focus group session, a note taker produced a de-identified written record of the incident narratives. At the end of the session, participants reviewed each written incident report, and made edits and corrections as necessary. The incidents were later analyzed to identify contributing factors, with a focus on design issues that either hindered or assisted the pilot during the events. A total of 90 incidents were reported. Human factor issues included the impact of reduced sensory cues, traffic separation in the absence of an out-the-window view, control latencies, vigilance during monotonous and ultra-long endurance flights, control station design considerations, transfer of control between control stations, the management of lost link procedures, and decision-making during emergencies. Pilots participated willingly and enthusiastically in the study

  3. Face-to-Face Interference in Typical and Atypical Development

    Science.gov (United States)

    Riby, Deborah M.; Doherty-Sneddon, Gwyneth; Whittle, Lisa

    2012-01-01

    Visual communication cues facilitate interpersonal communication. It is important that we look at faces to retrieve and subsequently process such cues. It is also important that we sometimes look away from faces as they increase cognitive load that may interfere with online processing. Indeed, when typically developing individuals hold face gaze…

  4. Gendered Perceptions of Typical Engineers across Specialties for Engineering Majors

    Science.gov (United States)

    Kelley, Margaret S.; Bryan, Kimberley K.

    2018-01-01

    Young women do not choose to be engineers nearly as often as young men, and they tend to cluster in particular specialties when they do. We examine these patterns and the role of gender schemas as applied to perceptions of typical engineers in understanding the choices that women make in terms of engineering specialties. We use Part 1 of two waves…

  5. The Roots of Disillusioned American Dream in Typical American

    Institute of Scientific and Technical Information of China (English)

    古冬华

    2016-01-01

    Typical American is one of Gish Jen’s notable novels catching attention of the American literary circle. The motif of disillusioned American dream can be seen clearly through the experiences of three main characters. From perspectives of the consumer culture and cultural conflicts, this paper analyzes the roots of the disillusioned American dream in the novel.

  6. Analogical Reasoning Ability in Autistic and Typically Developing Children

    Science.gov (United States)

    Morsanyi, Kinga; Holyoak, Keith J.

    2010-01-01

    Recent studies (e.g. Dawson et al., 2007) have reported that autistic people perform in the normal range on the Raven Progressive Matrices test, a formal reasoning test that requires integration of relations as well as the ability to infer rules and form high-level abstractions. Here we compared autistic and typically developing children, matched…

  7. Breast Metastases from Extramammary Malignancies: Typical and Atypical Ultrasound Features

    Energy Technology Data Exchange (ETDEWEB)

    Mun, Sung Hee [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Department of Radiology, Catholic University of Daegu College of Medicine, Daegu 712-702 (Korea, Republic of); Ko, Eun Young; Han, Boo-Kyung; Shin, Jung Hee [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Kim, Suk Jung [Department of Radiology, Inje University College of Medicine, Busan Paik Hospital, Busan 614-735 (Korea, Republic of); Cho, Eun Yoon [Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of)

    2014-07-01

    Breast metastases from extramammary malignancies are uncommon. The most common sources are lymphomas/leukemias and melanomas. Some of the less common sources include carcinomas of the lung, ovary, and stomach, and infrequently, carcinoid tumors, hypernephromas, carcinomas of the liver, tonsil, pleura, pancreas, cervix, perineum, endometrium and bladder. Breast metastases from extramammary malignancies have both hematogenous and lymphatic routes. According to their routes, there are common radiological features of metastatic diseases of the breast, but the features are not specific for metastases. Typical ultrasound (US) features of hematogenous metastases include single or multiple, round to oval shaped, well-circumscribed hypoechoic masses without spiculations, calcifications, or architectural distortion; these masses are commonly located superficially in subcutaneous tissue or immediately adjacent to the breast parenchyma that is relatively rich in blood supply. Typical US features of lymphatic breast metastases include diffusely and heterogeneously increased echogenicities in subcutaneous fat and glandular tissue and a thick trabecular pattern with secondary skin thickening, lymphedema, and lymph node enlargement. However, lesions show variable US features in some cases, and differentiation of these lesions from primary breast cancer or from benign lesions is difficult. In this review, we demonstrate various US appearances of breast metastases from extramammary malignancies as typical and atypical features, based on the results of US and other imaging studies performed at our institution. Awareness of the typical and atypical imaging features of these lesions may be helpful to diagnose metastatic lesions of the breast.

  8. Physico-chemical properties and fertility status of some typic ...

    African Journals Online (AJOL)

    Physico-chemical properties and fertility status of some typic plinthaquults in bauchi loval government area of Bauchi state, Nigeria. S Mustapha. Abstract. No Abstract. IJOTAFS Vol. 1 (2) 2007: pp. 120-124. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  9. Spectra of conditionalization and typicality in the multiverse

    Science.gov (United States)

    Azhar, Feraz

    2016-02-01

    An approach to testing theories describing a multiverse, that has gained interest of late, involves comparing theory-generated probability distributions over observables with their experimentally measured values. It is likely that such distributions, were we indeed able to calculate them unambiguously, will assign low probabilities to any such experimental measurements. An alternative to thereby rejecting these theories, is to conditionalize the distributions involved by restricting attention to domains of the multiverse in which we might arise. In order to elicit a crisp prediction, however, one needs to make a further assumption about how typical we are of the chosen domains. In this paper, we investigate interactions between the spectra of available assumptions regarding both conditionalization and typicality, and draw out the effects of these interactions in a concrete setting; namely, on predictions of the total number of species that contribute significantly to dark matter. In particular, for each conditionalization scheme studied, we analyze how correlations between densities of different dark matter species affect the prediction, and explicate the effects of assumptions regarding typicality. We find that the effects of correlations can depend on the conditionalization scheme, and that in each case atypicality can significantly change the prediction. In doing so, we demonstrate the existence of overlaps in the predictions of different "frameworks" consisting of conjunctions of theory, conditionalization scheme and typicality assumption. This conclusion highlights the acute challenges involved in using such tests to identify a preferred framework that aims to describe our observational situation in a multiverse.

  10. 7 CFR 632.52 - Identifying typical classes of action.

    Science.gov (United States)

    2010-01-01

    ... § 632.52 Identifying typical classes of action. (a) The RFO will analyze the environmental assessment of....12. These actions are determined by a limited environmental assessment that reasonably identifies the... 632.52 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES...

  11. Characteristics of typical Pierce guns for PPM focused TWTs

    International Nuclear Information System (INIS)

    Harper, R.; Puri, M.P.

    1989-01-01

    The performance of typical moderate perveance Pierce type electron guns which are used in periodic permanent magnet focused traveling wave tubes are described with regard to adaptation for use in electron beam ion sources. The results of detailed electron trajectory computations for one particular gun design are presented

  12. Human Behavior, Learning, and the Developing Brain: Typical Development

    Science.gov (United States)

    Coch, Donna, Ed.; Fischer, Kurt W., Ed.; Dawson, Geraldine, Ed.

    2010-01-01

    This volume brings together leading authorities from multiple disciplines to examine the relationship between brain development and behavior in typically developing children. Presented are innovative cross-sectional and longitudinal studies that shed light on brain-behavior connections in infancy and toddlerhood through adolescence. Chapters…

  13. Breast Metastases from Extramammary Malignancies: Typical and Atypical Ultrasound Features

    International Nuclear Information System (INIS)

    Mun, Sung Hee; Ko, Eun Young; Han, Boo-Kyung; Shin, Jung Hee; Kim, Suk Jung; Cho, Eun Yoon

    2014-01-01

    Breast metastases from extramammary malignancies are uncommon. The most common sources are lymphomas/leukemias and melanomas. Some of the less common sources include carcinomas of the lung, ovary, and stomach, and infrequently, carcinoid tumors, hypernephromas, carcinomas of the liver, tonsil, pleura, pancreas, cervix, perineum, endometrium and bladder. Breast metastases from extramammary malignancies have both hematogenous and lymphatic routes. According to their routes, there are common radiological features of metastatic diseases of the breast, but the features are not specific for metastases. Typical ultrasound (US) features of hematogenous metastases include single or multiple, round to oval shaped, well-circumscribed hypoechoic masses without spiculations, calcifications, or architectural distortion; these masses are commonly located superficially in subcutaneous tissue or immediately adjacent to the breast parenchyma that is relatively rich in blood supply. Typical US features of lymphatic breast metastases include diffusely and heterogeneously increased echogenicities in subcutaneous fat and glandular tissue and a thick trabecular pattern with secondary skin thickening, lymphedema, and lymph node enlargement. However, lesions show variable US features in some cases, and differentiation of these lesions from primary breast cancer or from benign lesions is difficult. In this review, we demonstrate various US appearances of breast metastases from extramammary malignancies as typical and atypical features, based on the results of US and other imaging studies performed at our institution. Awareness of the typical and atypical imaging features of these lesions may be helpful to diagnose metastatic lesions of the breast

  14. Typical School Day Experiences of Indian Children in Different Contexts.

    Science.gov (United States)

    Jaya, N.; Malar, G.

    2003-01-01

    Notes that India has experienced conditions that have lead to significant illiteracy, but that commitment to education can be found in lesser-known parts of India today. Profiles three schools in Tamil Nadu and describes a typical school day for a student with special needs, a student in a tribal setting, and a student in a rural setting. (TJQ)

  15. Typical and Atypical Dementia Family Caregivers: Systematic and Objective Comparisons

    Science.gov (United States)

    Nichols, Linda O.; Martindale-Adams, Jennifer; Burns, Robert; Graney, Marshall J.; Zuber, Jeffrey

    2011-01-01

    This systematic, objective comparison of typical (spouse, children) and atypical (in-law, sibling, nephew/niece, grandchild) dementia family caregivers examined demographic, caregiving and clinical variables. Analysis was of 1,476 caregivers, of whom 125 were atypical, from the Resources for Enhancing Alzheimer's Caregivers Health (REACH I and II)…

  16. The UCOR pilot plant and the development of axial flow compressors

    International Nuclear Information System (INIS)

    Grant, W.

    1984-01-01

    This article discusses some of the mechanical aspects of the Uranium Enrichment Corporation of South Africa (Pty) Ltd. (UCOR) pilot plant. The most important mechanical components in a typical stage in the pilot plant, consists of a compressor which is used to compress the process gas mixture. After air cooling to almost room temperature, the mixture is fed through the separation elements. Other components are two pressure vessels connected to the compressor. The development and characteristics of the pilot plant is described in the article

  17. Typical load shapes for six categories of Swedish commercial buildings

    Energy Technology Data Exchange (ETDEWEB)

    Noren, C.

    1997-01-01

    In co-operation with several Swedish electricity suppliers, typical load shapes have been developed for six categories of commercial buildings located in the south of Sweden. The categories included in the study are: hotels, warehouses/grocery stores, schools with no kitchen, schools with kitchen, office buildings, health, health buildings. Load shapes are developed for different mean daily outdoor temperatures and for different day types, normally standard weekdays and standard weekends. The load shapes are presented as non-dimensional normalized 1-hour load. All measured loads for an object are divided by the object`s mean load during the measuring period and typical load shapes are developed for each category of buildings. Thus errors were kept lower as compared to use of W/m{sup 2}-terms. Typical daytime (9 a.m. - 5 p.m.) standard deviations are 7-10% of the mean values for standard weekdays but during very cold or warm weather conditions, single objects can deviate from the typical load shape. On weekends, errors are higher and depending on very different activity levels in the buildings, it is difficult to develop weekend load shapes with good accuracy. The method presented is very easy to use for similar studies and no building simulation programs are needed. If more load data is available, a good method to lower the errors is to make sure that every category only consists of objects with the same activity level, both on weekdays and weekends. To make it easier to use the load shapes, Excel load shape workbooks have been developed, where it is even possible to compare typical load shapes with measured data. 23 refs, 53 figs, 20 tabs

  18. Agricultural Pilot's Audiological Profile

    Directory of Open Access Journals (Sweden)

    Foltz, Lucas

    2010-09-01

    Full Text Available Introduction: The agricultural airplane pilot are daily exposed to intense noises, being susceptible to the noise-induced hearing loss (NIHL and its auditory and extra auditory effects. Objective: To analyze the audiological profile of this population, verifying the work's influence on its hearing. Method: It was realized a retrospective, individual, observational, and cross-sectional study through the data obtained by means of a questionnaire and audiometric thresholds of 41 agricultural pilots. To the statistical analysis were utilized the chi-square, Spearman, and Wilcoxon tests with significance level of 5%. Results: It was verified that 95,1% of the pilots use PPE ( personal protective equipment during flight and 58,5% have contact with pesticides. More than half of individuals referred to feel auditory and extra auditory symptoms, being the buzz the more frequent (29,1%. It has the occurrence of 29,3% of NIHL suggestive hearing loss and 68,3% of normality, taking this presence of unilateral notch in 24,4% and bilateral notch in 31,7%. It was found correlation statistically significant in the associations between time of service and the average of the acute frequencies in the right ear (p=0038, and in the left ear (p=0,010. It has a statistical tendency in the association between audiometric configuration and contact with pesticides (p=0,088. Conclusion: The hearing loss prevalence in this study was showed high. More than half of the sample has normal audiometric thresholds with notch configuration. Such data lead to the conclusion that the agricultural pilots, even with PPE use, they still suffer with the damages caused by noise, needing best proposals of hearing loss prevention.

  19. A pilot study of rivastigmine in the treatment of delirium after stroke: A safe alternative

    Directory of Open Access Journals (Sweden)

    Jansen Ben PW

    2008-09-01

    Full Text Available Abstract Background Delirium is a common disorder in the early phase of stroke. Given the presumed cholinergic deficiency in delirium, we tested treatment with the acetylcholinesterase inhibitor rivastigmine. Methods This pilot study was performed within an epidemiological study. In 527 consecutive stroke patients presence of delirium was assessed during the first week with the confusion assessment method. Severity was scored with the delirium rating scale (DRS. Sixty-two patients developed a delirium in the acute phase of stroke. Only patients with a severe and persistent delirium (defined as a DRS of 12 or more for more than 24 hours were enrolled in the present study. In total 26 fulfilled these criteria of whom 17 were treated with orally administered rivastigmine with a total dose between 3 and 12 mg a day. Eight patients could not be treated because of dysphagia and one because of early discharge. Results No major side effects were recorded. In 16 patients there was a considerable decrease in severity of delirium. The mean DRS declined from 14.8 on day one to 8.5 after therapy and 5.6 after tapering. The mean duration of delirium was 6.7 days (range; 2–17. Conclusion Rivastigmine is safe in stroke patients with delirium even after rapid titration. In the majority of patients the delirium improved after treatment. A randomized controlled trial is needed to establish the usefulness of rivastigmine in delirium after stroke. Trial registration Nederlands Trial Register NTR1395

  20. Process Experimental Pilot Plant

    International Nuclear Information System (INIS)

    Henze, H.

    1986-01-01

    The Process Experimental Pilot Plant (PREPP) at the Idaho National Engineering Laboratory (INEL) was built to convert transuranic contaminated solid waste into a form acceptable for disposal at the Waste Isolation Pilot Plant (WIPP), located near Carlsbad, New Mexico. There are about 2.0 million cubic ft of transuranic waste stored at the Transuranic Storage Area of the INEL's Radioactive Waste Management Complex (RWMC). The Stored Waste Examination Pilot Plant (SWEPP) located at the RWMC will examine this stored transuranic waste to determine if the waste is acceptable for direct shipment to and storage at WIPP, or if it requires shipment to PREPP for processing before shipment to WIPP. The PREPP process shreds the waste, incinerates the shredded waste, and cements (grouts) the shredded incinerated waste in new 55-gal drums. Unshreddable items are repackaged and returned to SWEPP. The process off-gas is cleaned prior to its discharge to the atmosphere, and complies with the effluent standards of the State of Idaho, EPA, and DOE. Waste liquid generated is used in the grouting operation

  1. 76 FR 19267 - Pilot, Flight Instructor, and Pilot School Certification; Technical Amendment

    Science.gov (United States)

    2011-04-07

    .... No. 61-127] RIN 2120-AI86 Pilot, Flight Instructor, and Pilot School Certification; Technical... for pilots, flight instructors, ground instructors, and pilot schools. This document reinstates two... entitled, ``Pilot, Flight Instructor, and Pilot School Certification; Final Rule'' (74 FR 42500). That...

  2. The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037

    Directory of Open Access Journals (Sweden)

    Bruin Sjoerd C

    2010-10-01

    for both purulent and faecal generalised peritonitis. Trial registration Nederlands Trial Register NTR2037

  3. Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342).

    Science.gov (United States)

    van Hoogenhuijze, N E; Torrance, H L; Mol, F; Laven, J S E; Scheenjes, E; Traas, M A F; Janssen, C; Cohlen, B; Teklenburg, G; de Bruin, J P; van Oppenraaij, R; Maas, J W M; Moll, E; Fleischer, K; van Hooff, M H; de Koning, C; Cantineau, A; Lambalk, C B; Verberg, M; Nijs, M; Manger, A P; van Rumste, M; van der Voet, L F; Preys-Bosman, A; Visser, J; Brinkhuis, E; den Hartog, J E; Sluijmer, A; Jansen, F W; Hermes, W; Bandell, M L; Pelinck, M J; van Disseldorp, J; van Wely, M; Smeenk, J; Pieterse, Q D; Boxmeer, J C; Groenewoud, E R; Eijkemans, M J C; Kasius, J C; Broekmans, F J M

    2017-07-21

    Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2 nd fresh IVF/ICSI cycle. Secondary endpoints are costs, cumulative live birth rate (after the full 2 nd IVF/ICSI cycle and over 12 months of follow-up); clinical and ongoing pregnancy rate; multiple pregnancy rate; miscarriage rate and endometrial tissue parameters associated with implantation failure. Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle. NTR 5342 , registered July 31 st , 2015. Version 4.10, January 4th, 2017.

  4. Narrative versus Style : Effect of Genre Typical Events versus Genre Typical Filmic Realizations on Film Viewers' Genre Recognition

    NARCIS (Netherlands)

    Visch, V.; Tan, E.

    2008-01-01

    This study investigated whether film viewers recognize four basic genres (comic, drama, action and nonfiction) on the basis of genre-typical event cues or of genretypical filmic realization cues of events. Event cues are similar to the narrative content of a film sequence, while filmic realization

  5. LANCELOT pilot report, June 2007

    DEFF Research Database (Denmark)

    Levinsen, Karin; Meyer, Bente

    The aim of the Lancelot pilot evaluation process was to understand how teachers learn to teach and to relate to the online environment through the specific context of the Lancelot live online course. Following the Action Research in the autumn of 2006 the LANCELOT live online language course...... was revised for the piloting in the spring of 2007. A second aim of the pilot evaluation has therefore been to assess the revision of the course following the Action Research....

  6. The Importance of Pilot Studies

    OpenAIRE

    Van Teijlingen, Edwin; Hundley, Vanora

    2001-01-01

    The term 'pilot studies' refers to mini versions of a full-scale study (also called 'feasibility' studies), as well as the specific pre-testing of a particular research instrument such as a questionnaire or interview schedule. \\ud Pilot studies are a crucial element of a good study design. Conducting a pilot study does not guarantee success in the main study, but it does increase the likelihood. \\ud Pilot studies fulfil a range of important functions and can provide valuable insights for othe...

  7. SSI response of a typical shear wall structure

    International Nuclear Information System (INIS)

    Johnson, J.J.; Maslenikov, O.R.; Schewe, E.C.

    1985-01-01

    The seismic response of a typical shear structure in a commercial nuclear power plant was investigated for a series of site and foundation conditions using best estimate and design procedures. The structure selected is a part of the Zion AFT complex which is a connected group of reinforced concrete shear wall buildings, typical of nuclear power plant structures. Comparisons between best estimate responses quantified the effects of placing the structure on different sites and founding it in different manners. Calibration factors were developed by comparing simplified SSI design procedure responses to responses calculated by best estimate procedures. Nineteen basic cases were analyzed - each case was analyzed for ten earthquakes targeted to the NRC R.G. 1.60 design response spectra. The structure is a part of the Zion auxiliary-fuel handling turbine building (AFT) complex to the Zion nuclear power plants. (orig./HP)

  8. Analysis of typical meteorological years in different climates of China

    International Nuclear Information System (INIS)

    Yang, Liu; Lam, Joseph C.; Liu, Jiaping

    2007-01-01

    Typical meteorological years (TMYs) for 60 cities in the five major climatic zones (severe cold, cold, hot summer and cold winter, hot summer and warm winter, mild) in China were investigated. Long term (1971-2000) measured weather data such as dry bulb and dew point temperatures, wind speed and global solar radiation were gathered and analysed. A total of seven climatic indices were used to select the 12 typical meteorological months (TMMs) that made up the TMY for each city. In general, the cumulative distribution functions of the TMMs selected tended to follow their long term counterparts quite well. There was no persistent trend in any particular years being more representative than the others, though 1978 and 1982 tended to be picked most often. This paper presents the work and its findings. Future work on the assessment of TMYs in building energy simulation is also discussed

  9. Memory for radio advertisements: the effect of program and typicality.

    Science.gov (United States)

    Martín-Luengo, Beatriz; Luna, Karlos; Migueles, Malen

    2013-01-01

    We examined the influence of the type of radio program on the memory for radio advertisements. We also investigated the role in memory of the typicality (high or low) of the elements of the products advertised. Participants listened to three types of programs (interesting, boring, enjoyable) with two advertisements embedded in each. After completing a filler task, the participants performed a true/false recognition test. Hits and false alarm rates were higher for the interesting and enjoyable programs than for the boring one. There were also more hits and false alarms for the high-typicality elements. The response criterion for the advertisements embedded in the boring program was stricter than for the advertisements in other types of programs. We conclude that the type of program in which an advertisement is inserted and the nature of the elements of the advertisement affect both the number of hits and false alarms and the response criterion, but not the accuracy of the memory.

  10. Verbal communication skills in typical language development: a case series.

    Science.gov (United States)

    Abe, Camila Mayumi; Bretanha, Andreza Carolina; Bozza, Amanda; Ferraro, Gyovanna Junya Klinke; Lopes-Herrera, Simone Aparecida

    2013-01-01

    The aim of the current study was to investigate verbal communication skills in children with typical language development and ages between 6 and 8 years. Participants were 10 children of both genders in this age range without language alterations. A 30-minute video of each child's interaction with an adult (father and/or mother) was recorded, fully transcribed, and analyzed by two trained researchers in order to determine reliability. The recordings were analyzed according to a protocol that categorizes verbal communicative abilities, including dialogic, regulatory, narrative-discursive, and non-interactive skills. The frequency of use of each category of verbal communicative ability was analyzed (in percentage) for each subject. All subjects used more dialogical and regulatory skills, followed by narrative-discursive and non-interactive skills. This suggests that children in this age range are committed to continue dialog, which shows that children with typical language development have more dialogic interactions during spontaneous interactions with a familiar adult.

  11. Monte Carlo based radial shield design of typical PWR reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gul, Anas; Khan, Rustam; Qureshi, M. Ayub; Azeem, Muhammad Waqar; Raza, S.A. [Pakistan Institute of Engineering and Applied Sciences, Islamabad (Pakistan). Dept. of Nuclear Engineering; Stummer, Thomas [Technische Univ. Wien (Austria). Atominst.

    2017-04-15

    This paper presents the radiation shielding model of a typical PWR (CNPP-II) at Chashma, Pakistan. The model was developed using Monte Carlo N Particle code [2], equipped with ENDF/B-VI continuous energy cross section libraries. This model was applied to calculate the neutron and gamma flux and dose rates in the radial direction at core mid plane. The simulated results were compared with the reference results of Shanghai Nuclear Engineering Research and Design Institute (SNERDI).

  12. Typical event horizons in AdS/CFT

    Energy Technology Data Exchange (ETDEWEB)

    Avery, Steven G.; Lowe, David A. [Department of Physics, Brown University,Providence, RI 02912 (United States)

    2016-01-14

    We consider the construction of local bulk operators in a black hole background dual to a pure state in conformal field theory. The properties of these operators in a microcanonical ensemble are studied. It has been argued in the literature that typical states in such an ensemble contain firewalls, or otherwise singular horizons. We argue this conclusion can be avoided with a proper definition of the interior operators.

  13. Typical event horizons in AdS/CFT

    Science.gov (United States)

    Avery, Steven G.; Lowe, David A.

    2016-01-01

    We consider the construction of local bulk operators in a black hole background dual to a pure state in conformal field theory. The properties of these operators in a microcanonical ensemble are studied. It has been argued in the literature that typical states in such an ensemble contain firewalls, or otherwise singular horizons. We argue this conclusion can be avoided with a proper definition of the interior operators.

  14. Lipoma arborescens: Comparison of typical and atypical disease presentations

    International Nuclear Information System (INIS)

    Howe, B.M.; Wenger, D.E.

    2013-01-01

    Aim: To determine whether the aetiology differed between typical cases of lipoma arborescens with unilateral knee involvement and atypical cases involving joints other than the knee, polyarticular disease, and disease outside of the knee joint. Materials and methods: Cases of lipoma arborescens involving the knee joint were evaluated for the distribution of the disease and severity of degenerative arthritis. Joints other than the knee were evaluated for the presence and severity of degenerative arthritis, and the distribution was classified as either intra-articular, extra-articular, or both. Clinical history was reviewed for patient age at presentation, a history of inflammatory arthritis, diabetes mellitus, and known steroid use. Fisher's exact test was used to determine whether there was a statistically significant difference between typical and atypical presentations of the disease. Results: Lipoma arborescens was identified in 45 joints in 39 patients. Twenty-eight patients were classified as “typical” and 11 patients had “atypical” disease. There was no significant difference in age at presentation, presence of degenerative arthritis, or known inflammatory arthritis when comparing typical and atypical presentations of the disease. Conclusion: Twenty-eight percent of patients in the present study had atypical presentation of lipoma arborescens with multifocal lipoma arborescens or disease in joints other than the knee. There was no significant difference in age at presentation, presence of degenerative arthritis, or known inflammatory arthritis when comparing typical and atypical presentations of the disease. Of the 39 patients, only three had no evidence of degenerative arthritis, which suggests that many cases of lipoma arborescens are secondary to chronic reactive change in association with degenerative arthritis

  15. Theory of Mind experience sampling in typical adults.

    Science.gov (United States)

    Bryant, Lauren; Coffey, Anna; Povinelli, Daniel J; Pruett, John R

    2013-09-01

    We explored the frequency with which typical adults make Theory of Mind (ToM) attributions, and under what circumstances these attributions occur. We used an experience sampling method to query 30 typical adults about their everyday thoughts. Participants carried a Personal Data Assistant (PDA) that prompted them to categorize their thoughts as Action, Mental State, or Miscellaneous at approximately 30 pseudo-random times during a continuous 10-h period. Additionally, participants noted the direction of their thought (self versus other) and degree of socializing (with people versus alone) at the time of inquiry. We were interested in the relative frequency of ToM (mental state attributions) and how prominent they were in immediate social exchanges. Analyses of multiple choice answers suggest that typical adults: (1) spend more time thinking about actions than mental states and miscellaneous things, (2) exhibit a higher degree of own- versus other-directed thought when alone, and (3) make mental state attributions more frequently when not interacting (offline) than while interacting with others (online). A significant 3-way interaction between thought type, direction of thought, and socializing emerged because action but not mental state thoughts about others occurred more frequently when participants were interacting with people versus when alone; whereas there was an increase in the frequency of both action and mental state attributions about the self when participants were alone as opposed to socializing. A secondary analysis of coded free text responses supports findings 1-3. The results of this study help to create a more naturalistic picture of ToM use in everyday life and the method shows promise for future study of typical and atypical thought processes. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. Analysis and Comparison of Typical Models within Distribution Network Design

    DEFF Research Database (Denmark)

    Jørgensen, Hans Jacob; Larsen, Allan; Madsen, Oli B.G.

    This paper investigates the characteristics of typical optimisation models within Distribution Network Design. During the paper fourteen models known from the literature will be thoroughly analysed. Through this analysis a schematic approach to categorisation of distribution network design models...... for educational purposes. Furthermore, the paper can be seen as a practical introduction to network design modelling as well as a being an art manual or recipe when constructing such a model....

  17. Rural Tourism and Local Development: Typical Productions of Lazio

    Directory of Open Access Journals (Sweden)

    Francesco Maria Olivieri

    2014-12-01

    Full Text Available The local development is based on the integration of the tourism sector with the whole economy. The rural tourism seems to be a good occasion to analyse the local development: consumption of "tourist products" located in specific local contexts. Starting from the food and wine supply chain and the localization of typical productions, the aim of the present work will be analyse the relationship with local development, rural tourism sustainability and accommodation system, referring to Lazio. Which are the findings to create tourism local system based on the relationship with touristic and food and wine supply chain? Italian tourism is based on accommodation system, so the whole consideration of the Italian cultural tourism: tourism made in Italy. The touristic added value to specific local context takes advantage from the synergy with food and wine supply chain: made in Italy of typical productions. Agritourism could be better accommodation typology to rural tourism and to exclusivity of consumption typical productions. The reciprocity among food and wine supply chain and tourism provides new insights on the key topics related to tourism development and to the organization of geographical space as well and considering its important contribution nowadays to the economic competitiveness.

  18. Typically Female Features in Hungarian Shopping Tourism

    Directory of Open Access Journals (Sweden)

    Gábor Michalkó

    2006-06-01

    Full Text Available Although shopping has been long acknowledged as a major tourist activity, the extent and characteristics of shopping tourism have only recently become the subject of academic research and discussion. As a contribution to this field of knowledge, the paper presents the characteristics of shopping tourism in Hungary, and discusses the typically female features of outbound Hungarian shopping tourism. The research is based on a survey of 2473 Hungarian tourists carried out in 2005. As the findings of the study indicate, while female respondents were altogether more likely to be involved in tourist shopping than male travellers, no significant difference was experienced between the genders concerning the share of shopping expenses compared to their total travel budget. In their shopping behaviour, women were typically affected by price levels, and they proved to be both more selfish and more altruistic than men by purchasing more products for themselves and for their family members. The most significant differences between men and women were found in their product preferences as female tourists were more likely to purchase typically feminine goods such as clothes, shoes, bags and accessories, in the timing of shopping activities while abroad, and in the information sources used by tourists, since interpersonal influences such as friends’, guides’ and fellow travellers’ recommendations played a higher role in female travellers’ decisions.

  19. The relationship between manual handling performance and recent flying experience in air transport pilots.

    Science.gov (United States)

    Ebbatson, Matt; Harris, Don; Huddlestone, John; Sears, Rodney

    2010-02-01

    Modern jet transport aircraft are typically flown using the on-board automation by the pilot programming commands into the auto-flight systems. Anecdotal evidence exists suggesting that pilots of highly automated aircraft experience manual flying skills decay as a result of a lack of opportunity to practise hand-flying during line operations. The ability of a pilot to revert to basic manual control is essential, for example, in cases where the aircraft's automatic capability is diminished or when reconfiguring the automatics is an ineffective use of crew capacity. However, there is a paucity of objective data to substantiate this perceived threat to flight safety. Furthermore, traditional performance measurement techniques may lack the ability to identify subtle but significant differences in pilots' manual handling ability in large transport aircraft. This study examines the relationship between pilot manual handling performance and their recent flying experience using both traditional flight path tracking measures and frequency-based control strategy measures. Significant relationships are identified between pilots' very recent flying experience and their manual control strategy. Statement of Relevance: The study demonstrates a novel application of frequency analysis, which produces a broader and more sensitive analysis of pilot performance than has been offered in previous research. Additionally, the relationships that are found to exist between recent flying experience and manual flying performance will help to guide future pilot assessment and training.

  20. Narrative versus Style: Effect of Genre Typical Events versus Genre Typical Filmic Realizations on Film Viewers' Genre Recognition

    OpenAIRE

    Visch, V.; Tan, E.

    2008-01-01

    This study investigated whether film viewers recognize four basic genres (comic, drama, action and nonfiction) on the basis of genre-typical event cues or of genretypical filmic realization cues of events. Event cues are similar to the narrative content of a film sequence, while filmic realization cues are similar to stylistic surface cues of a film sequence. It was predicted that genre recognition of short film fragments is cued more by filmic realization cues than by event cues. The results...

  1. Pilot plant study

    International Nuclear Information System (INIS)

    Morris, M.E.

    1978-01-01

    Sandia Laboratories undertook the design and fabrication of an 8 ton/day dry sewage sludge irradiatior. The facility is intended (1) to function as a high-gamma-dose rate research facility; (2) to be a testbed for the unique electrical and mechanical components to be used in larger facilities; (3) to fulfill the formal requirements of a pilot plant so that design and construction of a demonstration facility could proceed; and (4) to provide accurate data base on construction and operating experience for the Environmental Impact Assessment (EIA), the Safety Analysis Report (SAR), and the cost analyses for a larger facility. The facility and its component systems are described in detail

  2. Priming a Pilot Implementation

    DEFF Research Database (Denmark)

    Hansen, Magnus; Ie Pedersen, Maria

    Abstract. We report on the initial findings of an action research study about effects specifications. It is a part of larger IS pilot implementation project conducted in the Danish healthcare sector. Through interviews and a workshop we have identified and specified the main effects that comprise...... the basis for the evaluation of the project. The study indicates that cross-organisational effects specifications cause a significant number of effects. To further prioritize these we argue that both interview and workshop must be facilitated as mutual learning processes between interviewer and interviewee....

  3. Enlisted or Officer Drone Pilots

    Science.gov (United States)

    2010-04-01

    the property of the United States government. AU/ACSC/Rafnson, Gary B/AY10 3 Abstract This paper compares remotely piloted aircraft— drones ...operations in both the US Army and US Air Force. It argues that officers should continue to pilot Air Force drones because of the increased risks and

  4. Dysphonia Severity Index in Typically Developing Indian Children.

    Science.gov (United States)

    Pebbili, Gopi Kishore; Kidwai, Juhi; Shabnam, Srushti

    2017-01-01

    Dysphonia is a variation in an individual's quality, pitch, or loudness from the voice characteristics typical of a speaker of similar age, gender, cultural background, and geographic location. Dysphonia Severity Index (DSI) is a recognized assessment tool based on a weighted combination of maximum phonation time, highest frequency, lowest intensity, and jitter (%) of an individual. Although dysphonia in adults is accurately evaluated using DSI, standard reference values for school-age children have not been studied. This study aims to document the DSI scores in typically developing children (8-12 years). A total of 42 typically developing children (8-12 years) without complaint of voice problem on the day of testing participated in the study. DSI was computed by substituting the raw scores of substituent parameters: maximum phonation time, highest frequency, lowest intensity, and jitter% using various modules of CSL 4500 software. The average DSI values obtained in children were 2.9 (1.23) and 3.8 (1.29) for males and females, respectively. DSI values are found to be significantly higher (P = 0.027) for females than those for males in Indian children. This could be attributed to the anatomical and behavioral differences among females and males. Further, pubertal changes set in earlier for females approximating an adult-like physiology, thereby leading to higher DSI values in them. The mean DSI value obtained for male and female Indian children can be used as a preliminary reference data against which the DSI values of school-age children with dysphonia can be compared. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  5. A generalized window energy rating system for typical office buildings

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Cheng; Chen, Tingyao; Yang, Hongxing; Chung, Tse-ming [Research Center for Building Environmental Engineering, Department of Building Services Engineering, The Hong Kong Polytechnic University, Hong Kong (China)

    2010-07-15

    Detailed computer simulation programs require lengthy inputs, and cannot directly provide an insight to relationship between the window energy performance and the key window design parameters. Hence, several window energy rating systems (WERS) for residential houses and small buildings have been developed in different countries. Many studies showed that utilization of daylight through elaborate design and operation of windows leads to significant energy savings in both cooling and lighting in office buildings. However, the current WERSs do not consider daylighting effect, while most of daylighting analyses do not take into account the influence of convective and infiltration heat gains. Therefore, a generalized WERS for typical office buildings has been presented, which takes all primary influence factors into account. The model includes embodied and operation energy uses and savings by a window to fully reflect interactions among the influence parameters. Reference locations selected for artificial lighting and glare control in the current common simulation practice may cause uncompromised conflicts, which could result in over- or under-estimated energy performance. Widely used computer programs, DOE2 and ADELINE, for hourly daylighting and cooling simulations have their own weaknesses, which may result in unrealistic or inaccurate results. An approach is also presented for taking the advantages of the both programs and avoiding their weaknesses. The model and approach have been applied to a typical office building of Hong Kong as an example to demonstrate how a WERS in a particular location can be established and how well the model can work. The energy effect of window properties, window-to-wall ratio (WWR), building orientation and lighting control strategies have been analyzed, and can be indicated by the localized WERS. An application example also demonstrates that the algebraic WERS derived from simulation results can be easily used for the optimal design of

  6. Benefit and cost curves for typical pollination mutualisms.

    Science.gov (United States)

    Morris, William F; Vázquez, Diego P; Chacoff, Natacha P

    2010-05-01

    Mutualisms provide benefits to interacting species, but they also involve costs. If costs come to exceed benefits as population density or the frequency of encounters between species increases, the interaction will no longer be mutualistic. Thus curves that represent benefits and costs as functions of interaction frequency are important tools for predicting when a mutualism will tip over into antagonism. Currently, most of what we know about benefit and cost curves in pollination mutualisms comes from highly specialized pollinating seed-consumer mutualisms, such as the yucca moth-yucca interaction. There, benefits to female reproduction saturate as the number of visits to a flower increases (because the amount of pollen needed to fertilize all the flower's ovules is finite), but costs continue to increase (because pollinator offspring consume developing seeds), leading to a peak in seed production at an intermediate number of visits. But for most plant-pollinator mutualisms, costs to the plant are more subtle than consumption of seeds, and how such costs scale with interaction frequency remains largely unknown. Here, we present reasonable benefit and cost curves that are appropriate for typical pollinator-plant interactions, and we show how they can result in a wide diversity of relationships between net benefit (benefit minus cost) and interaction frequency. We then use maximum-likelihood methods to fit net-benefit curves to measures of female reproductive success for three typical pollination mutualisms from two continents, and for each system we chose the most parsimonious model using information-criterion statistics. We discuss the implications of the shape of the net-benefit curve for the ecology and evolution of plant-pollinator mutualisms, as well as the challenges that lie ahead for disentangling the underlying benefit and cost curves for typical pollination mutualisms.

  7. SSI response of a typical shear wall structure. Volume 1

    International Nuclear Information System (INIS)

    Johnson, J.J.; Schewe, E.C.; Maslenikov, O.R.

    1984-04-01

    The Simplified Methods project of the US NRC-funded Seismic Safety Margins Research Program (SSMRP) has as its goal the development of a methodology to perform routine seismic probabilistic risk assessments of commercial nuclear power plants. The study reported here develops calibration factors to relate best estimate response to design values accounting for approximations and simplifications in SSI analysis procedures. Nineteen cases were analyzed and in-structure response compared. The structure of interest was a typical shear wall structure. 6 references, 44 figures, 22 tables

  8. Typical exposure of children to EMF: exposimetry and dosimetry

    International Nuclear Information System (INIS)

    Valic, Blaz; Kos, Bor; Gajsek, Peter

    2015-01-01

    A survey study with portable exposimeters, worn by 21 children under the age of 17, and detailed measurements in an apartment above a transformer substation were carried out to determine the typical individual exposure of children to extremely low- and radio-frequency (RF) electromagnetic field. In total, portable exposimeters were worn for >2400 h. Based on the typical individual exposure the in situ electric field and specific absorption rate (SAR) values were calculated for an 11-y-old female human model. The average exposure was determined to be low compared with ICNIRP reference levels: 0.29 μT for an extremely low frequency (ELF) magnetic field and 0.09 V m -1 for GSM base stations, 0.11 V m -1 for DECT and 0.10 V m -1 for WiFi; other contributions could be neglected. However, some of the volunteers were more exposed: the highest realistic exposure, to which children could be exposed for a prolonged period of time, was 1.35 μT for ELF magnetic field and 0.38 V m -1 for DECT, 0.13 V m -1 for WiFi and 0.26 V m -1 for GSM base stations. Numerical calculations of the in situ electric field and SAR values for the typical and the worst-case situation show that, compared with ICNIRP basic restrictions, the average exposure is low. In the typical exposure scenario, the extremely low frequency exposure is <0.03 % and the RF exposure <0.001 % of the corresponding basic restriction. In the worst-case situation, the extremely low frequency exposure is <0.11 % and the RF exposure <0.007 % of the corresponding basic restrictions. Analysis of the exposures and the individual's perception of being exposed/ unexposed to an ELF magnetic field showed that it is impossible to estimate the individual exposure to an ELF magnetic field based only on the information provided by the individuals, as they do not have enough knowledge and information to properly identify the sources in their vicinity. (authors)

  9. The Compositions: Biodegradable Material - Typical Resin, as Moulding Sands’ Binders

    Directory of Open Access Journals (Sweden)

    Major-Gabryś K.

    2015-03-01

    Full Text Available The paper presents possibility of using biodegradable materials as parts of moulding sands’ binders based on commonly used in foundry practice resins. The authors focus on thermal destruction of binding materials and thermal deformation of moulding sands with tested materials. All the research is conducted for the biodegradable material and two typical resins separately. The point of the article is to show if tested materials are compatible from thermal destruction and thermal deformation points of view. It was proved that tested materials characterized with similar thermal destruction but thermal deformation of moulding sands with those binders was different.

  10. Monte Carlo based radial shield design of typical PWR reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gul, Anas; Khan, Rustam; Qureshi, M. Ayub; Azeem, Muhammad Waqar; Raza, S.A. [Pakistan Institute of Engineering and Applied Sciences, Islamabad (Pakistan). Dept. of Nuclear Engineering; Stummer, Thomas [Technische Univ. Wien (Austria). Atominst.

    2016-11-15

    Neutron and gamma flux and dose equivalent rate distribution are analysed in radial and shields of a typical PWR type reactor based on the Monte Carlo radiation transport computer code MCNP5. The ENDF/B-VI continuous energy cross-section library has been employed for the criticality and shielding analysis. The computed results are in good agreement with the reference results (maximum difference is less than 56 %). It implies that MCNP5 a good tool for accurate prediction of neutron and gamma flux and dose rates in radial shield around the core of PWR type reactors.

  11. Lipomatosis of the sciatic nerve: typical and atypical MRI features

    International Nuclear Information System (INIS)

    Wong, Bernadette Zhi Ying; Amrami, Kimberly K.; Wenger, Doris E.; Dyck, P. James B.; Scheithauer, Bernd W.; Spinner, Robert J.

    2006-01-01

    Lipomatosis of nerve, also known as fibrolipomatous hamartoma, is a rare condition of nerve, usually affecting the median nerve. The MRI appearance is characteristic. We describe two cases of lipomatosis of nerve involving the sciatic nerve, an extremely unusual location for this lesion, in patients with sciatic neuropathy. These cases share the typical features previously described in the literature for other nerves, but also contain atypical features not previously highlighted, relating to the variability in distribution and extent of the fatty deposition. Recognition of the MRI appearance of this entity is important in order to avoid unnecessary attempts at surgical resection of this lesion. (orig.)

  12. Characterising mechanical transmission wire ropes’ typical failure modes

    Directory of Open Access Journals (Sweden)

    Edgar Espejo

    2007-01-01

    Full Text Available The National University of Colombia’s Engineering School’s AFIS research group has helped several public and private institutions during the last five years in analysing the causes of failures presented in elevation and trans- port machinery leading to expensive consequences and even the loss of life. A group of typical wire rope failure modes have been identified, along with their common causes. These are presented in this work to offer help to our industry’s engineers and technicians, allowing them to identify possible risk situations in their routine work regarding the wire ropes which they use and approaches for carrying out wire rope failure analysis.

  13. Typical IAEA operations at a fuel fabrication plant

    International Nuclear Information System (INIS)

    Morsy, S.

    1984-01-01

    The IAEA operations performed at a typical Fuel Fabrication Plant are explained. To make the analysis less general the case of Low Enriched Uranium (LEU) Fuel Fabrication Plants is considered. Many of the conclusions drawn from this analysis could be extended to other types of fabrication plants. The safeguards objectives and goals at LEU Fuel Fabrication Plants are defined followed by a brief description of the fabrication process. The basic philosophy behind nuclear material stratification and the concept of Material Balance Areas (MBA's) and Key Measurement Points (KMP's) is explained. The Agency operations and verification methods used during physical inventory verifications are illustrated

  14. Working memory training improves reading processes in typically developing children.

    Science.gov (United States)

    Loosli, Sandra V; Buschkuehl, Martin; Perrig, Walter J; Jaeggi, Susanne M

    2012-01-01

    The goal of this study was to investigate whether a brief cognitive training intervention results in a specific performance increase in the trained task, and whether there are transfer effects to other nontrained measures. A computerized, adaptive working memory intervention was conducted with 9- to 11-year-old typically developing children. The children considerably improved their performance in the trained working memory task. Additionally, compared to a matched control group, the experimental group significantly enhanced their reading performance after training, providing further evidence for shared processes between working memory and reading.

  15. Assessment of the quality seen in a restaurant typical theme

    Directory of Open Access Journals (Sweden)

    Francisco Alves Pinheiro

    2009-03-01

    Full Text Available To ensure the satisfaction of external customers it is necessary to know their needs. In this perspective, these work objectives assess the perception of quality by the customer outside of a restaurant located in the a restaurant typical theme located in the square of food “Bodódromo” the city of Petrolina/Pe. For both this was a case study, using the model servqual, Parasuraman et al (1985, for removal of information. The results indicated a need for improvement in the services provided by the restaurant.

  16. Results from the CERN pilot CLOUD experiment

    CERN Document Server

    Duplissy, J; Reichl, U; Winkler, P M; Pedersen, E; Makhmutov, V; Viisanen, Y; Kulmala, M; Wilhelmsson, M; Weingartner, E; Avngaard, M; Curtius, J; Veenhof, R; Laakso, L; Gagne, S; Harrison, R G; Sipila, M; David, A; Seinfeld, J H; Nieminen, T; Verheggen, B; Aplin, K L; Stratmann, F; Arnold, F; Makela, J; Kellett, B; Fastrup, B; Marsh, N D; Lockwood, M; Carslaw, K; Wehrle, G; Aufmhoff, H; Pedersen, J O P; Baltensperger, U; Onnela, A; Laaksonen, A; Enghoff, M B; Svensmark, J; Wex, H; Lillestol, E; Wagner, P E; Kirkby, J; Stozhkov, Y; Polny, J; Bondo, T; Bingham, R; Svensmark, H

    2010-01-01

    During a 4-week run in October-November 2006, a pilot experiment was performed at the CERN Proton Synchrotron in preparation for the Cosmics Leaving OUtdoor Droplets (CLOUD) experiment, whose aim is to study the possible influence of cosmic rays on clouds. The purpose of the pilot experiment was firstly to carry out exploratory measurements of the effect of ionising particle radiation on aerosol formation from trace H2SO4 vapour and secondly to provide technical input for the CLOUD design. A total of 44 nucleation bursts were produced and recorded, with formation rates of particles above the 3 nm detection threshold of between 0.1 and 100 cm(-3) s(-1), and growth rates between 2 and 37 nm h(-1). The corresponding H2SO4 concentrations were typically around 10(6) cm(-3) or less. The experimentally-measured formation rates and H2SO4 concentrations are comparable to those found in the atmosphere, supporting the idea that sulphuric acid is involved in the nucleation of atmospheric aerosols. However, sulphuric acid...

  17. Epidemiologic studies of pilots and aircrew.

    Science.gov (United States)

    Boice, J D; Blettner, M; Auvinen, A

    2000-11-01

    During flight, pilots and cabin crew are exposed to increased levels of cosmic radiation which consists primarily of neutrons and gamma rays. Neutron dosimetry is not straightforward, but typical annual effective doses are estimated to range between two and five mSv. Higher dose rates are experienced at the highest altitudes and in the polar regions. Mean doses have been increasing over time as longer flights at higher altitudes have become more frequent. Because there are so few populations exposed to neutrons, studies of airline personnel are of particular interest. However, because the cumulative radiation exposure is so low, statistical power is a major concern. Further, finding an appropriate comparison group is problematic due to selection into these occupations and a number of biases are possible. For example, increased rates of breast cancer among flight attendants have been attributed to reproductive factors such as nulliparity and increased rates of melanoma among pilots have been attributed to excessive sun exposure during leisure time activities. Epidemiologic studies conducted over the last 20 y provide little consistent evidence linking cancer with radiation exposures from air travel.

  18. Prediction of pilot induced oscillations

    Directory of Open Access Journals (Sweden)

    Valentin PANĂ

    2011-03-01

    Full Text Available An important problem in the design of flight-control systems for aircraft under pilotedcontrol is the determination of handling qualities and pilot-induced oscillations (PIO tendencieswhen significant nonlinearities exist in the vehicle description. The paper presents a method to detectpossible pilot-induced oscillations of Category II (with rate and position limiting, a phenomenonusually due to a misadaptation between the pilot and the aircraft response during some tasks in whichtight closed loop control of the aircraft is required from the pilot. For the analysis of Pilot in the LoopOscillations an approach, based on robust stability analysis of a system subject to uncertainparameters, is proposed. In this analysis the nonlinear elements are substituted by linear uncertainparameters. This approach assumes that PIO are characterized by a limit cycle behavior.

  19. Live Piloting and Prototyping

    Directory of Open Access Journals (Sweden)

    Francesca Rizzo

    2013-07-01

    Full Text Available This paper presents current trends in service design research concerning large scale projects aimed at generating changes at a local scale. The strategy adopted to achieve this, is to co-design solutions including future users in the development process, prototyping and testing system of products and services before their actual implementation. On the basis of experience achieved in the European Project Life 2.0, this paper discusses which methods and competencies are applied in the development of these projects, eliciting the lessons learnt especially from the piloting phase in which the participatory design (PD approach plays a major role. In the first part, the topic is introduced jointly with the theoretical background where the user center design and participatory design methods are presented; then the Life 2.0 project development is described; finally the experience is discussed from a service design perspective, eliciting guidelines for piloting and prototyping services in a real context of use. The paper concludes reflecting on the designers’ role and competencies needed in this process.

  20. Hydrogen deflagration simulations under typical containment conditions for nuclear safety

    Energy Technology Data Exchange (ETDEWEB)

    Yanez, J., E-mail: jorge.yanez@kit.edu [Institute for Energy and Nuclear Technology, Karlsruhe Institute of Technology, Kaiserstrasse 12, 76131 Karlsruhe (Germany); Kotchourko, A.; Lelyakin, A. [Institute for Energy and Nuclear Technology, Karlsruhe Institute of Technology, Kaiserstrasse 12, 76131 Karlsruhe (Germany)

    2012-09-15

    Highlights: Black-Right-Pointing-Pointer Lean H{sub 2}-air combustion experiments highly relevant to typical NPP simulated. Black-Right-Pointing-Pointer Analyzed effect of temperature, concentration of H{sub 2}, and steam concentration. Black-Right-Pointing-Pointer Similar conditions and H{sub 2} concentration yielded different combustion regimes. Black-Right-Pointing-Pointer Flame instabilities (FIs) were the effect driving divergences. Black-Right-Pointing-Pointer Model developed for acoustic FI in simulations. Agreement experiments obtained. - Abstract: This paper presents the modeling of low-concentration hydrogen deflagrations performed with the recently developed KYLCOM model specially created to perform calculations in large scale domains. Three experiments carried out in THAI facility (performed in the frames of international OECD THAI experimental program) were selected to be analyzed. The tests allow studying lean mixture hydrogen combustion at normal ambient, elevated temperature and superheated and saturated conditions. The experimental conditions considered together with the facility size and shape grant a high relevance degree to the typical NPP containment conditions. The results of the simulations were thoroughly compared with the experimental data, and the comparison was supplemented by the analysis of the combustion regimes taking place in the considered tests. Results of the analysis demonstrated that despite the comparatively small difference in mixture properties, three different combustion regimes can be definitely identified. The simulations of one of the cases required of the modeling of the acoustic-parametric instability which was carefully undertaken.

  1. Plutonium-239 production rate study using a typical fusion reactor

    International Nuclear Information System (INIS)

    Faghihi, F.; Havasi, H.; Amin-Mozafari, M.

    2008-01-01

    The purpose of the present paper is to compute fissile 239 Pu material by supposed typical fusion reactor operation to make the fuel requirement for other purposes (e.g. MOX fissile fuel, etc.). It is assumed that there is a fusion reactor has a cylindrical geometry and uses uniformly distributed deuterium-tritium as fuel so that neutron wall load is taken at 10(MW)/(m 2 ) . Moreover, the reactor core is surrounded by six suggested blankets to make best performance of the physical conditions described herein. We determined neutron flux in each considered blanket as well as tritium self-sufficiency using two groups neutron energy and then computation is followed by the MCNP-4C code. Finally, material depletion according to a set of dynamical coupled differential equations is solved to estimate 239 Pu production rate. Produced 239 Pu is compared with two typical fission reactors to find performance of plutonium breeding ratio in the case of the fusion reactor. We found that 0.92% of initial U is converted into fissile Pu by our suggested fusion reactor with thermal power of 3000 MW. For comparison, 239 Pu yield of suggested large scale PWR is about 0.65% and for LMFBR is close to 1.7%. The results show that the fusion reactor has an acceptable efficiency for Pu production compared with a large scale PWR fission reactor type

  2. Plutonium-239 production rate study using a typical fusion reactor

    Energy Technology Data Exchange (ETDEWEB)

    Faghihi, F. [Research Center for Radiation Protection, Shiraz University, Shiraz (Iran, Islamic Republic of)], E-mail: faghihif@shirazu.ac.ir; Havasi, H.; Amin-Mozafari, M. [Department of Nuclear Engineering, School of Engineering, Shiraz University, 71348-51154 Shiraz (Iran, Islamic Republic of)

    2008-05-15

    The purpose of the present paper is to compute fissile {sup 239}Pu material by supposed typical fusion reactor operation to make the fuel requirement for other purposes (e.g. MOX fissile fuel, etc.). It is assumed that there is a fusion reactor has a cylindrical geometry and uses uniformly distributed deuterium-tritium as fuel so that neutron wall load is taken at 10(MW)/(m{sup 2}) . Moreover, the reactor core is surrounded by six suggested blankets to make best performance of the physical conditions described herein. We determined neutron flux in each considered blanket as well as tritium self-sufficiency using two groups neutron energy and then computation is followed by the MCNP-4C code. Finally, material depletion according to a set of dynamical coupled differential equations is solved to estimate {sup 239}Pu production rate. Produced {sup 239}Pu is compared with two typical fission reactors to find performance of plutonium breeding ratio in the case of the fusion reactor. We found that 0.92% of initial U is converted into fissile Pu by our suggested fusion reactor with thermal power of 3000 MW. For comparison, {sup 239}Pu yield of suggested large scale PWR is about 0.65% and for LMFBR is close to 1.7%. The results show that the fusion reactor has an acceptable efficiency for Pu production compared with a large scale PWR fission reactor type.

  3. Daily intakes of naturally occurring radioisotopes in typical Korean foods

    International Nuclear Information System (INIS)

    Choi, Min-Seok; Lin Xiujing; Lee, Sun Ah; Kim, Wan; Kang, Hee-Dong; Doh, Sih-Hong; Kim, Do-Sung; Lee, Dong-Myung

    2008-01-01

    The concentrations of naturally occurring radioisotopes ( 232 Th, 228 Th, 230 Th, 228 Ra, 226 Ra, and 40 K) in typical Korean foods were evaluated. The daily intakes of these radioisotopes were calculated by comparing concentrations in typical Korean foods and the daily consumption rates of these foods. Daily intakes were as follows: 232 Th, 0.00-0.23; 228 Th, 0.00-2.04; 230 Th, 0.00-0.26; 228 Ra, 0.02-2.73; 226 Ra, 0.01-4.37 mBq/day; and 40 K, 0.01-5.71 Bq/day. The total daily intake of the naturally occurring radioisotopes measured in this study from food was 39.46 Bq/day. The total annual internal dose resulting from ingestion of radioisotopes in food was 109.83 μSv/y, and the radioisotope with the highest daily intake was 40 K. These values were same level compiled in other countries

  4. Emotion, gender, and gender typical identity in autobiographical memory.

    Science.gov (United States)

    Grysman, Azriel; Merrill, Natalie; Fivush, Robyn

    2017-03-01

    Gender differences in the emotional intensity and content of autobiographical memory (AM) are inconsistent across studies, and may be influenced as much by gender identity as by categorical gender. To explore this question, data were collected from 196 participants (age 18-40), split evenly between men and women. Participants narrated four memories, a neutral event, high point event, low point event, and self-defining memory, completed ratings of emotional intensity for each event, and completed four measures of gender typical identity. For self-reported emotional intensity, gender differences in AM were mediated by identification with stereotypical feminine gender norms. For narrative use of affect terms, both gender and gender typical identity predicted affective expression. The results confirm contextual models of gender identity (e.g., Diamond, 2012 . The desire disorder in research on sexual orientation in women: Contributions of dynamical systems theory. Archives of Sexual Behavior, 41, 73-83) and underscore the dynamic interplay between gender and gender identity in the emotional expression of autobiographical memories.

  5. A study on prioritizing typical women’s entrepreneur characteristics

    Directory of Open Access Journals (Sweden)

    Ebrahim Ramezani

    2014-07-01

    Full Text Available Entrepreneurship is one of the main pivot of progress and growth of every country. The spread of entrepreneurship particularly the role of women in this category has speeded up today more than any other times. Many of researchers believe that attention to women entrepreneurship plays remarkable role in soundness and safety of nation’s economy. Maybe in Iran less attention has been paid to this matter in proportion to other countries and due to various reasons, there are not many entrepreneur woman. However, employing typical entrepreneur women in various fields of productivity, industrial, commercial, social and cultural and even higher than these, in country’s political issue proves that women’s role is magnificent and in many cases they enjoy higher abilities in portion to men. In this paper, using additive ratio assessment (ARAS as a prioritizing method, eleven entrepreneur women were chosen for prioritizing criteria for measuring a typical women’s entrepreneurship characteristics. The results show that the balance between work and family among criteria are propounded as the highest weight and fulfilling different jobs simultaneously as the lowest weight.

  6. Pilots 2.0: DIRAC pilots for all the skies

    CERN Document Server

    Stagni, F; McNab, A; Luzzi, C

    2015-01-01

    In the last few years, new types of computing infrastructures, such as IAAS (Infrastructure as a Service) and IAAC (Infrastructure as a Client), gained popularity. New resources may come as part of pledged resources, while others are opportunistic. Most of these new infrastructures are based on virtualization techniques. Meanwhile, some concepts, such as distributed queues, lost appeal, while still supporting a vast amount of resources. Virtual Organizations are therefore facing heterogeneity of the available resources and the use of an Interware software like DIRAC to hide the diversity of underlying resources has become essential. The DIRAC WMS is based on the concept of pilot jobs that was introduced back in 2004. A pilot is what creates the possibility to run jobs on a worker node. Within DIRAC, we developed a new generation of pilot jobs, that we dubbed Pilots 2.0. Pilots 2.0 are not tied to a specific infrastructure; rather they are generic, fully configurable and extendible pilots. A Pilot 2.0 can be s...

  7. DiAlert: a prevention program for overweight first degree relatives of type 2 diabetes patients: results of a pilot study to test feasibility and acceptability

    Directory of Open Access Journals (Sweden)

    Heideman Wieke H

    2012-09-01

    Full Text Available Abstract Background Prevalence of type 2 diabetes mellitus is increasing due to lifestyle changes, particularly affecting those genetically at risk. We developed DiAlert as a targeted group-based intervention aimed to promote intrinsic motivation and action planning for lifestyle changes and weight loss in first degree relatives of patients with type 2 diabetes mellitus. The main objective of the pilot of the DiAlert intervention was to assess fidelity, feasibility and acceptability prior to starting the randomized controlled trial. Methods Individuals with a family history of type 2 diabetes mellitus were self-identified and screened for eligibility. DiAlert consists of two group sessions. Feasibility, fidelity, acceptability and self-reported perceptions and behavioral determinants were evaluated in a pre-post study using questionnaires and observations. Determinants of behavior change were analyzed using paired-samples t tests and Wilcoxon signed rank tests. Results DiAlert was delivered to two groups of first degree relatives of patients with type 2 diabetes mellitus (N = 9 and N = 12. Feasibility and fidelity were confirmed. Overall, the DiAlert group sessions were positively evaluated (8.0 on a scale of 1 to 10 by participants. The intervention did not impact perceived susceptibility or worry about personal diabetes risk. Action planning with regard to changing diet and physical activity increased. Conclusions DiAlert proved feasible and was well-accepted by participants. Positive trends in action planning indicate increased likelihood of actual behavior change following DiAlert. Testing the effectiveness in a randomized controlled trial is imperative. Trial registration Netherlands National Trial Register (NTR: NTR2036

  8. Economy of typical food: technical restrictions and organizative challenges

    Directory of Open Access Journals (Sweden)

    Elena Viganò

    2009-10-01

    Full Text Available The economic analysis of typical agri-food products requires to be focused on the following issues: i the specific features of the offering system; ii the technical restrictions established by the EU regulations on Protected designation of origin (Pdo and Pgi and, iii the strategies aimed at product differentiation and for value creation for the consumer. Considering this latest aspect, it is important to notice that the specificity of the agricultural raw materials, the use of traditional production techniques of production coming from the tradition of the place and certification represent only a prerequisite for the differentiation of the product on the market against standard products. The problem is that the specificity of local product comes from attributes (tangible and intangible of quality which are not directly accessible, nor verifiable, by the consumer when he/she makes purchasing choices. This situation persists despite the greater propensity of modern consumer to make investments in information and his/her greater attention and larger background towards the acknowledgement of different offers based on quality. This paper tends to develop an analysis on a theoretical and operative basis upon open strategies that can be implemented at the enterprise level, and that of agro-food chain and of territorial system in order to promote the quality of products to consumers. In particular, the work addresses the problems connected to the establishment of competitive advantages for Protected Designation of Origin (Pdo and Protected Geographical Indication (Pgi, highlighting that in order to achieve those advantages, firms offering typical products need to differentiate their offering on both material and immaterial ground acting on intrinsic and extrinsic attributes of quality of products, on specific features (natural, historical, cultural, etc. of territorial, on the efficiency of the offering organizational structure, and finally on the

  9. Economy of typical food: technical restrictions and organizative challenges

    Directory of Open Access Journals (Sweden)

    Elena Viganò

    2011-02-01

    Full Text Available The economic analysis of typical agri-food products requires to be focused on the following issues: i the specific features of the offering system; ii the technical restrictions established by the EU regulations on Protected designation of origin (Pdo and Pgi and, iii the strategies aimed at product differentiation and for value creation for the consumer. Considering this latest aspect, it is important to notice that the specificity of the agricultural raw materials, the use of traditional production techniques of production coming from the tradition of the place and certification represent only a prerequisite for the differentiation of the product on the market against standard products. The problem is that the specificity of local product comes from attributes (tangible and intangible of quality which are not directly accessible, nor verifiable, by the consumer when he/she makes purchasing choices. This situation persists despite the greater propensity of modern consumer to make investments in information and his/her greater attention and larger background towards the acknowledgement of different offers based on quality. This paper tends to develop an analysis on a theoretical and operative basis upon open strategies that can be implemented at the enterprise level, and that of agro-food chain and of territorial system in order to promote the quality of products to consumers. In particular, the work addresses the problems connected to the establishment of competitive advantages for Protected Designation of Origin (Pdo and Protected Geographical Indication (Pgi, highlighting that in order to achieve those advantages, firms offering typical products need to differentiate their offering on both material and immaterial ground acting on intrinsic and extrinsic attributes of quality of products, on specific features (natural, historical, cultural, etc. of territorial, on the efficiency of the offering organizational structure, and finally on the

  10. 76 FR 78141 - Pilot, Flight Instructor, and Pilot School Certification; Technical Amendment

    Science.gov (United States)

    2011-12-16

    ...-26661; Amdt. No. 61-129] RIN 2120-AI86 Pilot, Flight Instructor, and Pilot School Certification... requirements for pilots, flight instructors, ground instructors, and pilot schools. This document corrects an... a practical test for the issuance of a sport pilot certificate in a light-sport aircraft other than...

  11. Acoustical conditions of typical classrooms in Hong Kong

    Science.gov (United States)

    Li, Kai Ming; Lam, Coriolanus C. L.

    2005-04-01

    This paper presents measurement results of the acoustical environments of local schools in Hong Kong. In the measurements, several acoustical aspects that affect verbal communication in classrooms have been studied. These conditions include outdoor and indoor ambient noise levels, signal-to-noise ratios, reverberation time and the speech transmission index. Typical classrooms in many different schools and other higher-education institutions have been selected in the present study. Experimental results are compared with such national standards as USA (ANSI S 12.60 V 2002), Australian/New Zealand (AS/NZS 2107:2000), China (GB/T 15508 V 1995) and other national and industrial standards. This study will form the basis of devising acceptable standards for use in Hong Kong. [Work supported by the Research Grants Council of the SAR Government, the Research Committee of the Hong Kong Polytechnic University and Architectural Services Department of the Hong Kong SAR Government.

  12. Failure mode and effects analysis on typical reactor trip system

    International Nuclear Information System (INIS)

    Eisawy, E.A.

    2010-01-01

    An updated failure mode and effects analysis, FMEA , has been performed on a typical reactor trip system. This upgrade helps to avoid system damage and ,as a result, extends the system service life. It also provides for simplified maintenance and surveillance testing. The operating conditions under which the system is to carry out its function and the operational profile expected for the system have been determined. The results of the FMEA have been given in terms of operating states of the subsystem.The results are given in form of table which is set up such that for a given failure one can read across it and determine which items remain operating in the system. From this data one can identify the number of components operating in the system for monitors pressure exceeds the setpoint pressure.

  13. Typical and atypical radiological manifestations of renal oncocytoma

    International Nuclear Information System (INIS)

    Bernaldez, P.; Iriborreu, M. A.; Rodriguez, M. L.; Martinez-Moya, M.; Rodriguez, A.; Navarro, S.

    2001-01-01

    Asses the Radiologic findings [ conventional X-ray, intravenous urography (IU), ultrasonography and computerized tomography (CT) ] of the renal oncocytomas and determine if there are characteristics that allow us to differentiate them from renal cell carcinoma (RCC). We performed a retrospective study of eight patients diagnosed of renal oncocytoma, analyzing the characteristics found in the plain radiography and IVU, ultrasonography and CT without and with i. v. contrast. The masses were well defined in seven cases and poorly defined in one, and were homogeneous on four occasions and heterogeneous on two. The remaining two were homogeneous, except for the presence of a central scar. Two lesions showed and aggressive biological behavior, coinciding with signs suggestive of malignancy from the radiological point of view. The fibrous scar is a typical but infrequent findings in renal oncocytoma that we can only detect by CT. It is not possible to differentiate it from aggressive lesions with imaging techniques, although orientative findings exist. (Author) 17 refs

  14. Air Leakage Rates in Typical Air Barrier Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Hun, Diana E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Atchley, Jerald Allen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Childs, Phillip W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-11-01

    Estimates for 2010 indicate that infiltration in residential buildings was responsible for 2.85 quads of energy (DOE 2014), which is about 3% of the total energy consumed in the US. One of the mechanisms being implemented to reduce this energy penalty is the use of air barriers as part of the building envelope. These technologies decrease airflow through major leakage sites such as oriented strand board (OSB) joints, and gaps around penetrations (e.g., windows, doors, pipes, electrical outlets) as indicated by Hun et al. (2014). However, most air barrier materials do not properly address leakage spots such as wall-to-roof joints and wall-to-foundation joints because these are difficult to seal, and because air barrier manufacturers usually do not provide adequate instructions for these locations. The present study focuses on characterizing typical air leakage sites in wall assemblies with air barrier materials.

  15. Typical equilibrium state of an embedded quantum system.

    Science.gov (United States)

    Ithier, Grégoire; Ascroft, Saeed; Benaych-Georges, Florent

    2017-12-01

    We consider an arbitrary quantum system coupled nonperturbatively to a large arbitrary and fully quantum environment. In the work by Ithier and Benaych-Georges [Phys. Rev. A 96, 012108 (2017)2469-992610.1103/PhysRevA.96.012108] the typicality of the dynamics of such an embedded quantum system was established for several classes of random interactions. In other words, the time evolution of its quantum state does not depend on the microscopic details of the interaction. Focusing on the long-time regime, we use this property to calculate analytically a partition function characterizing the stationary state and involving the overlaps between eigenvectors of a bare and a dressed Hamiltonian. This partition function provides a thermodynamical ensemble which includes the microcanonical and canonical ensembles as particular cases. We check our predictions with numerical simulations.

  16. Anthropic reasoning and typicality in multiverse cosmology and string theory

    International Nuclear Information System (INIS)

    Weinstein, Steven

    2006-01-01

    Anthropic arguments in multiverse cosmology and string theory rely on the weak anthropic principle (WAP). We show that the principle is fundamentally ambiguous. It can be formulated in one of two ways, which we refer to as WAP 1 and WAP 2 . We show that WAP 2 , the version most commonly used in anthropic reasoning, makes no physical predictions unless supplemented by a further assumption of 'typicality', and we argue that this assumption is both misguided and unjustified. WAP 1 , however, requires no such supplementation; it directly implies that any theory that assigns a non-zero probability to our universe predicts that we will observe our universe with probability one. We argue, therefore, that WAP 1 is preferable, and note that it has the benefit of avoiding the inductive overreach characteristic of much anthropic reasoning

  17. Anthropic reasoning and typicality in multiverse cosmology and string theory

    Energy Technology Data Exchange (ETDEWEB)

    Weinstein, Steven [Perimeter Institute for Theoretical Physics, 31 Caroline St, Waterloo, ON N2L 2Y5 (Canada); Department of Philosophy, University of Waterloo, Waterloo, ON N2L 3G1 (Canada); Department of Physics, University of Waterloo, Waterloo, ON N2L 3G1 (Canada)

    2006-06-21

    Anthropic arguments in multiverse cosmology and string theory rely on the weak anthropic principle (WAP). We show that the principle is fundamentally ambiguous. It can be formulated in one of two ways, which we refer to as WAP{sub 1} and WAP{sub 2}. We show that WAP{sub 2}, the version most commonly used in anthropic reasoning, makes no physical predictions unless supplemented by a further assumption of 'typicality', and we argue that this assumption is both misguided and unjustified. WAP{sub 1}, however, requires no such supplementation; it directly implies that any theory that assigns a non-zero probability to our universe predicts that we will observe our universe with probability one. We argue, therefore, that WAP{sub 1} is preferable, and note that it has the benefit of avoiding the inductive overreach characteristic of much anthropic reasoning.

  18. Numerical Simulations for a Typical Train Fire in China

    Directory of Open Access Journals (Sweden)

    W. K. Chow

    2011-01-01

    Full Text Available Railway is the key transport means in China including the Mainland, Taiwan, and Hong Kong. Consequent to so many big arson and accidental fires in the public transport systems including trains and buses, fire safety in passenger trains is a concern. Numerical simulations with Computational Fluid Dynamics on identified fire scenarios with typical train compartments in China will be reported in this paper. The heat release rate of the first ignited item was taken as the input parameter. The mass lost rate of fuel vapor of other combustibles was estimated to predict the resultant heat release rates by the combustion models in the software. Results on air flow, velocity vectors, temperature distribution, smoke layer height, and smoke spread patterns inside the train compartment were analyzed. The results are useful for working out appropriate fire safety measures for train vehicles and determining the design fire for subway stations and railway tunnels.

  19. Aeroelastic Calculations Using CFD for a Typical Business Jet Model

    Science.gov (United States)

    Gibbons, Michael D.

    1996-01-01

    Two time-accurate Computational Fluid Dynamics (CFD) codes were used to compute several flutter points for a typical business jet model. The model consisted of a rigid fuselage with a flexible semispan wing and was tested in the Transonic Dynamics Tunnel at NASA Langley Research Center where experimental flutter data were obtained from M(sub infinity) = 0.628 to M(sub infinity) = 0.888. The computational results were computed using CFD codes based on the inviscid TSD equation (CAP-TSD) and the Euler/Navier-Stokes equations (CFL3D-AE). Comparisons are made between analytical results and with experiment where appropriate. The results presented here show that the Navier-Stokes method is required near the transonic dip due to the strong viscous effects while the TSD and Euler methods used here provide good results at the lower Mach numbers.

  20. GENERATION OF A TYPICAL METEOROLOGICAL YEAR FOR PORT HARCOURT ZONE

    Directory of Open Access Journals (Sweden)

    OGOLOMA O.B.

    2011-04-01

    Full Text Available This paper presents data for the typical meteorological year (TMY for the Port Harcourt climatic zone based on the hourly meteorological data recorded during the period 1983–2002, using the Finkelstein-Schafer statistical method. The data are the global solar radiation, wind velocity, dry bulb temperature, relative humidity, and others. The HVAC outside design conditions for the Port Harcourt climatic zone (latitude 4.44oN, longitude 7.1oE, elevation 20 m were found to be 26.7oC, 78.6% and 3.5 m/s for the dry bulb temperature, relative humidity and wind speed, respectively, and 13.5 MJ/m2/day for the global solar radiation. The TMY data for the zone are shown to be sufficiently reliable for engineering practice.

  1. 49 CFR 230.110 - Pilots.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Pilots. 230.110 Section 230.110 Transportation... and Equalizing System § 230.110 Pilots. (a) General provisions. Pilots shall be securely attached... clearance. The minimum clearance of pilot above the rail shall be 3 inches and the maximum clearance shall...

  2. Creep strain accumulation in a typical LMFBR piperun

    International Nuclear Information System (INIS)

    Johnstone, T.L.

    1975-01-01

    The analysis described allows the strain concentrations in typical LMFBR two anchor point uniplanar piperuns to be calculated. Account is taken of the effect of pipe elbows in attracting creep strain to themselves as well as possible movements of the thrust line due to strain redistribution. The influence of the initial load conditions is also examined. The stress relaxation analysis is facilitated by making the assumption that a cross-sectional stress distribution determined by the asymptotic fully developed state of creep exists at all times. Use is then made of Hoff(s) analogy between materials with a creep law of the Norton type and those with a corresponding non-linear elastic stress strain law, to determine complementary strain energy rates for straight pipes and bends. Ovalisation of the latter produces an increased strain energy rate which can be simply calculated by comparison with an equal length of straight pipe through employing a creep flexibility factor due to Spence. Deflection rates at any location in the pipework can then be evaluated in terms of the thermal restraint forces at that location by an application of Castigliano's principle. In particular for an anchor point the deflection rates are identically zero and this leads to the generation of 3 simultaneous differential equations determining the relaxation of the anchor reactions. Indicative results are presented for the continuous relaxation at 570 deg C of the thermally induced stress in a planar approximation to a typical LMFBR pipe run chosen to have peak elbow stresses close to the code maximum. The results indicate a ratio, after 10 5 hours, of 3 for creep strain concentration relative to initial peak strain (calculated on the assumption of fully elastic behavior) in the most severely affected elbow, when either austenitic 316 or 321 creep properties are employed

  3. Memory for sequences of events impaired in typical aging

    Science.gov (United States)

    Allen, Timothy A.; Morris, Andrea M.; Stark, Shauna M.; Fortin, Norbert J.

    2015-01-01

    Typical aging is associated with diminished episodic memory performance. To improve our understanding of the fundamental mechanisms underlying this age-related memory deficit, we previously developed an integrated, cross-species approach to link converging evidence from human and animal research. This novel approach focuses on the ability to remember sequences of events, an important feature of episodic memory. Unlike existing paradigms, this task is nonspatial, nonverbal, and can be used to isolate different cognitive processes that may be differentially affected in aging. Here, we used this task to make a comprehensive comparison of sequence memory performance between younger (18–22 yr) and older adults (62–86 yr). Specifically, participants viewed repeated sequences of six colored, fractal images and indicated whether each item was presented “in sequence” or “out of sequence.” Several out of sequence probe trials were used to provide a detailed assessment of sequence memory, including: (i) repeating an item from earlier in the sequence (“Repeats”; e.g., ABADEF), (ii) skipping ahead in the sequence (“Skips”; e.g., ABDDEF), and (iii) inserting an item from a different sequence into the same ordinal position (“Ordinal Transfers”; e.g., AB3DEF). We found that older adults performed as well as younger controls when tested on well-known and predictable sequences, but were severely impaired when tested using novel sequences. Importantly, overall sequence memory performance in older adults steadily declined with age, a decline not detected with other measures (RAVLT or BPS-O). We further characterized this deficit by showing that performance of older adults was severely impaired on specific probe trials that required detailed knowledge of the sequence (Skips and Ordinal Transfers), and was associated with a shift in their underlying mnemonic representation of the sequences. Collectively, these findings provide unambiguous evidence that the

  4. Far-infrared irradiation drying behavior of typical biomass briquettes

    International Nuclear Information System (INIS)

    Chen, N.N.; Chen, M.Q.; Fu, B.A.; Song, J.J.

    2017-01-01

    Infrared radiation drying behaviors of four typical biomass briquettes (populus tomentosa leaves, cotton stalk, spent coffee grounds and eucalyptus bark) were investigated based on a lab-scale setup. The effect of radiation source temperatures (100–200 °C) on the far-infrared drying kinetics and heat transfer of the samples was addressed. As the temperature went up from 100 °C to 200 °C, the time required for the four biomass briquettes drying decreased by about 59–66%, and the average values of temperature for the four biomass briquettes increased by about 33–39 °C, while the average radiation heat transfer fluxes increased by about 3.3 times (3.7 times only for the leaves). The specific energy consumptions were 0.622–0.849 kW h kg"−"1. The Modified Midilli model had the better representing for the moisture ratio change of the briquettes. The values of the activation energy for the briquettes in the first falling rate stage were between 20.35 and 24.83 kJ mol"−"1, while those in the second falling rate stage were between 17.89 and 21.93 kJ mol"−"1. The activation energy for the eucalyptus bark briquette in two falling rate stages was the least one, and that for the cotton stalk briquette was less than that for the rest two briquettes. - Highlights: • Far infrared drying behaviors of four typical biomass briquettes were addressed. • The effect of radiation source temperatures on IR drying kinetics was stated. • Radiation heat transfer flux between the sample and heater was evaluated. • Midilli model had the better representing for the drying process of the samples.

  5. DISRUPTION OF CONDITIONED REWARD ASSOCIATION BY TYPICAL AND ATYPICAL ANTIPSYCHOTICS

    Science.gov (United States)

    Danna, C.L.; Elmer, G.I.

    2013-01-01

    Antipsychotic drugs are broadly classified into typical and atypical compounds; they vary in their pharmacological profile however a common component is their antagonist effects at the D2 dopamine receptors (DRD2). Unfortunately, diminished DRD2 activation is generally thought to be associated with the severity of neuroleptic-induced anhedonia. The purpose of this study was to determine the effect of the atypical antipsychotic olanzapine and typical antipsychotic haloperidol in a paradigm that reflects the learned transfer of incentive motivational properties to previously neutral stimuli, namely autoshaping. In order to provide a dosing comparison to a therapeutically relevant endpoint, both drugs were tested against amphetamine-induced disruption of prepulse inhibition as well. In the autoshaping task, rats were exposed to repeated pairings of stimuli that were differentially predictive of reward delivery. Conditioned approach to the reward predictive cue (sign-tracking) and to the reward (goal-tracking) increased during repeated pairings in the vehicle treated rats. Haloperidol and olanzapine completely abolished this behavior at relatively low doses (100 μg/kg). This same dose was the threshold dose for each drug to antagonize the sensorimotor gating deficits produced by amphetamine. At lower doses (3–30 μg/kg) both drugs produced a dose-dependent decrease in conditioned approach to the reward predictive cue. There was no difference between drugs at this dose range which indicates that olanzapine disrupts autoshaping at a significantly lower proposed DRD2 receptor occupancy. Interestingly, neither drug disrupted conditioned approach to the reward at the same dose range that disrupted conditioned approach to the reward predictive cue. Thus, haloperidol and olanzapine, at doses well below what is considered therapeutically relevant, disrupts the attribution of incentive motivational value to previously neutral cues. Drug effects on this dimension of reward

  6. A brief history of typical absence seizures - Petit mal revisited.

    Science.gov (United States)

    Brigo, Francesco; Trinka, Eugen; Lattanzi, Simona; Bragazzi, Nicola Luigi; Nardone, Raffaele; Martini, Mariano

    2018-03-01

    In this article, we have traced back the history of typical absence seizures, from their initial clinical description to the more recent nosological position. The first description of absence seizures was made by Poupart in 1705 and Tissot in 1770. In 1824, Calmeil introduced the term "absences", and in 1838, Esquirol for the first time used the term petit mal. Reynolds instead used the term "epilepsia mitior" (milder epilepsy) and provided a comprehensive description of absence seizures (1861). In 1854, Delasiauve ranked absences as the seizure type with lower severity and introduced the concept of idiopathic epilepsy. Otto Binswanger (1899) discussed the role of cortex in the pathophysiology of "abortive seizures", whereas William Gowers (1901) emphasized the importance of a detailed clinical history to identify nonmotor seizures or very mild motor phenomena which otherwise may go unnoticed or considered not epileptic. At the beginning of the 20th Century, the term pyknolepsy was introduced, but initially was not universally considered as a type of epilepsy; it was definitely recognized as an epileptic entity only in 1945, based on electroencephalogram (EEG) recordings. Hans Berger, the inventor of the EEG, made also the first EEG recording of an atypical absence (his results were published only in 1933), whereas the characteristic EEG pattern was reported by neurophysiologists of the Harvard Medical School in 1935. The discovery of EEG made it also possible to differentiate absence seizures from so called "psychomotor" seizures occurring in temporal lobe epilepsy. Penfield and Jasper (1938) considered absences as expression of "centrencephalic epilepsy". Typical absences seizures are now classified by the International League Against Epilepsy among generalized nonmotor (absence) seizures. Copyright © 2018 Elsevier Inc. All rights reserved.

  7. New genetic tools to identify and protect typical italian products

    Directory of Open Access Journals (Sweden)

    Sergio Lanteri

    2011-02-01

    Full Text Available During last decades the use of local varieties was strongly reduced due to introduction of modern cultivars characterized by higher yield, and breed for different traits of agronomic value. However, these cultivars not always have the quality aspects that was found in old traditional and typical crops also depending from the know-how of traditional cultivation. Nowadays the practise of intensive agriculture select only a small number of species and varieties with a consequent reduction of the diversity in agro-ecosystems and risk of loss of important alleles characterizing genetic materials adapted to specific environments. The creation of quality marks of the European Union proved to be a successful system to protect typical products through the Denomination of Origins (PDO- Protected Denomination of Origin and PGI- Protected Geographical Indication. However, the protection of quality needs efficient instruments to discriminate DOP or IGP varieties in the field and to trace them along the agro-food chain. DNA fingerprinting represents an excellent system to discriminate herbaceous and tree species as well as to quantify the amount of genetic variability present in germplasm collections. The paper describes several examples in which AFLPs, SSRs and minisatellite markers were successfully used to identify tomato, artichoke, grape, apple and walnut varieties proving to be effective in discriminating also closely related genetic material. DNA fingerprinting based on SSR is also a powerful tool to trace and authenticate row plant materials in agro-food chains. The paper describes examples of varieties traceability in the food chains durum wheat, olive, apple and tomato pursued through the identification of SSR allelic profiles obtained from DNA isolated from complex highly processed food, such as bread, olive oil, apple pureè and nectar and peeled tomato.

  8. New genetic tools to identify and protect typical italian products

    Directory of Open Access Journals (Sweden)

    Sergio Lanteri

    2009-10-01

    Full Text Available During last decades the use of local varieties was strongly reduced due to introduction of modern cultivars characterized by higher yield, and breed for different traits of agronomic value. However, these cultivars not always have the quality aspects that was found in old traditional and typical crops also depending from the know-how of traditional cultivation. Nowadays the practise of intensive agriculture select only a small number of species and varieties with a consequent reduction of the diversity in agro-ecosystems and risk of loss of important alleles characterizing genetic materials adapted to specific environments. The creation of quality marks of the European Union proved to be a successful system to protect typical products through the Denomination of Origins (PDO- Protected Denomination of Origin and PGI- Protected Geographical Indication. However, the protection of quality needs efficient instruments to discriminate DOP or IGP varieties in the field and to trace them along the agro-food chain. DNA fingerprinting represents an excellent system to discriminate herbaceous and tree species as well as to quantify the amount of genetic variability present in germplasm collections. The paper describes several examples in which AFLPs, SSRs and minisatellite markers were successfully used to identify tomato, artichoke, grape, apple and walnut varieties proving to be effective in discriminating also closely related genetic material. DNA fingerprinting based on SSR is also a powerful tool to trace and authenticate row plant materials in agro-food chains. The paper describes examples of varieties traceability in the food chains durum wheat, olive, apple and tomato pursued through the identification of SSR allelic profiles obtained from DNA isolated from complex highly processed food, such as bread, olive oil, apple pureè and nectar and peeled tomato.

  9. Kvanefjeld refinery pilot plant operations

    International Nuclear Information System (INIS)

    Krebs, Damien; Furfaro, Domenic

    2016-01-01

    Greenland Minerals and Energy is a junior project development company which is listed on the Australian Stock Exchange (asx:GGG). It is developing the Kvanefjeld rare earth and uranium project located in the southern tip of Greenland. The project has completed a Feasibility Study and is currently in the permitting phase. Last year was a busy time for the company as it completed a Feasibility Study, a mining licence application (draft submitted in December 2015) and pilot plant operations. Beneficiation pilot plant operations were completed at GTK in Finland in April 2015. This pilot plant treated approximately 30 tonnes of ore to producing almost 2 tonnes of rare earth mineral concentrate. Later in the year a hydrometallurgical pilot plant was performed which mimicked the Refinery process. This pilot plant was performed at Outotec’s Pori Research laboratories in Finland from September till October 2015. The pilot plant treated approximately 200 kilograms of concentrate over 4 split operating campaigns. Each campaign was performed to focus on the performance of a specific part of the refinery flowsheet. This allowed for full operating focus on a single unit operation to ensure that it was operating correctly. The pilot plant operations were quite successful with no major issues with the flowsheet identified through continuous operation. Some fine tuning of conditions was required to ensure adequate removal of impurities was performed with recycle streams incorporated. Overall the leach extractions observed in the pilot plant exceeded the design assumptions in the Feasibility Study. These programs were partially funded by the EURARE program. The EURARE program aims to encourage the sustainable development of European based rare earth projects. This has the goal of allowing Europe to become less reliant on importation of these key raw materials. The professionalism and performance of both GTK and Outotec contributed significantly to the success of the pilot plant

  10. Priming a Pilot Implementation

    DEFF Research Database (Denmark)

    Hansen, Magnus Rotvit Perlt; Pedersen, Maria Ie

    2011-01-01

    Abstract. We report on the initial findings of an exploratory action research study about effects specifications using the systems development method Effects-driven IT development. It is part of a larger IS pilot implementation project conducted in the Danish healthcare sector. Through interviews...... and a workshop we have identified and specified effects that comprise the basis for an evaluation of the project between several organisational agents with diverse professional backgrounds. Gathering organisational participants at a workshop with a common goal of discussing and prioritizing a finished list...... of effects has proved to be a valuable approach to create mutual learning process amongst the participants and the facilitators of the workshop. The challenges we experienced during the effects specification process were to balance a dichotomous focus between on one hand the visions of the participants...

  11. Liverpool Telecare Pilot: case studies

    Directory of Open Access Journals (Sweden)

    Nigel Barnes

    2006-09-01

    Full Text Available Telecare services use information and communications technology (ICT to support the provision of care to people in their own homes. This paper describes a pilot telecare service employed by Liverpool (UK City Council to support a sample of their frail and elderly social services users. The pilot has been running for over two years and has been deployed for 21 individuals in Liverpool. In this paper we present the pilot system and provide real example cases which help to illustrate the benefits of such a system.

  12. Smart city pilot projects, scaling up or fading out? : Experiences from Amsterdam

    NARCIS (Netherlands)

    van Winden, W.

    2016-01-01

    In many cities, pilot projects are set up to test or develop new technologies that improve sustainability, urban quality of life or urban services (often labelled as “smart city” projects). Typically, these projects are supported by the municipality, funded by subsidies, and run in partnerships.

  13. A Pilot Study of a Kindergarten Summer School Reading Program in High-Poverty Urban Schools

    Science.gov (United States)

    Denton, Carolyn A.; Solari, Emily J.; Ciancio, Dennis J.; Hecht, Steven A.; Swank, Paul R.

    2010-01-01

    This pilot study examined an implementation of a kindergarten summer school reading program in 4 high-poverty urban schools. The program targeted both basic reading skills and oral language development. Students were randomly assigned to a treatment group (n = 25) or a typical practice comparison group (n = 28) within each school; however,…

  14. How Newspaper Advertising Sales Managers Spend Their Time: A Pilot Study.

    Science.gov (United States)

    Hudson, Jerry C.; Saathoff, Roger C.

    A pilot study examined how newspaper advertising sales managers in five southwestern states spend their time during a typical work day. Of the 360 questionnaires mailed, 176 responses were received. The largest number of responses (93) came from retail sales managers of newspapers in markets with less than 50,000 population. The questionnaire…

  15. Smart City pilot projects : exploring the dimensions and conditions of scaling up

    NARCIS (Netherlands)

    van Winden, W.; van den Buuse, D.J.H.M.

    2017-01-01

    In many cities, pilot projects are set up to test new technologies that help to address urban sustainability issues, improve the effectiveness of urban services, and enhance the quality of life of citizens. These projects, often labelled as “smart city” projects, are typically supported by

  16. Brief Report: Prevalence of Pervasive Developmental Disorder in Brazil--A Pilot Study

    Science.gov (United States)

    Paula, Cristiane S.; Ribeiro, Sabrina H.; Fombonne, Eric; Mercadante, Marcos T.

    2011-01-01

    This pilot study presents preliminary results concerning the prevalence of Pervasive Developmental Disorder (PDD) in South America. It was a three-phase study conducted in a typical town in Southeast Brazil. Case definition was based in a combination of standardized instruments and clinical evaluations by experts. The prevalence of PDD was…

  17. Longitudinal changes in cortical thickness in autism and typical development.

    Science.gov (United States)

    Zielinski, Brandon A; Prigge, Molly B D; Nielsen, Jared A; Froehlich, Alyson L; Abildskov, Tracy J; Anderson, Jeffrey S; Fletcher, P Thomas; Zygmunt, Kristen M; Travers, Brittany G; Lange, Nicholas; Alexander, Andrew L; Bigler, Erin D; Lainhart, Janet E

    2014-06-01

    The natural history of brain growth in autism spectrum disorders remains unclear. Cross-sectional studies have identified regional abnormalities in brain volume and cortical thickness in autism, although substantial discrepancies have been reported. Preliminary longitudinal studies using two time points and small samples have identified specific regional differences in cortical thickness in the disorder. To clarify age-related trajectories of cortical development, we examined longitudinal changes in cortical thickness within a large mixed cross-sectional and longitudinal sample of autistic subjects and age- and gender-matched typically developing controls. Three hundred and forty-five magnetic resonance imaging scans were examined from 97 males with autism (mean age = 16.8 years; range 3-36 years) and 60 males with typical development (mean age = 18 years; range 4-39 years), with an average interscan interval of 2.6 years. FreeSurfer image analysis software was used to parcellate the cortex into 34 regions of interest per hemisphere and to calculate mean cortical thickness for each region. Longitudinal linear mixed effects models were used to further characterize these findings and identify regions with between-group differences in longitudinal age-related trajectories. Using mean age at time of first scan as a reference (15 years), differences were observed in bilateral inferior frontal gyrus, pars opercularis and pars triangularis, right caudal middle frontal and left rostral middle frontal regions, and left frontal pole. However, group differences in cortical thickness varied by developmental stage, and were influenced by IQ. Differences in age-related trajectories emerged in bilateral parietal and occipital regions (postcentral gyrus, cuneus, lingual gyrus, pericalcarine cortex), left frontal regions (pars opercularis, rostral middle frontal and frontal pole), left supramarginal gyrus, and right transverse temporal gyrus, superior parietal lobule, and

  18. Waste Isolation Pilot Plant Overview

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, Douglas James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-03-27

    The mission of Waste Isolation Pilot Plant (WIPP) is to demonstrate the safe, environmentally sound, cost effective, permanent disposal of Transuranic (TRU) waste left from production of nuclear weapons.

  19. Rockfish Pilot Permit Program (RPP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rockfish Pilot Program was a five-year project that allowed harvesters to form voluntary cooperatives and receive an exclusive harvest privilege for groundfish...

  20. US Daily Pilot Balloon Observations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Pilot Balloon observational forms for the United States. Taken by Weather Bureau and U.S. Army observers. Period of record 1918-1960. Records scanned from the NCDC...

  1. WIPP: Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    1984-01-01

    The following aspects of the Waste Isolation Pilot Plant are discussed briefly: history and site selection; salt as a disposal medium; transporting waste materials; early key events; impacts on New Mexico; project organization; and site certification profile

  2. Vertebral pain in helicopter pilots

    Science.gov (United States)

    Auffret, R.; Delahaye, R. P.; Metges, P. J.; VICENS

    1980-01-01

    Pathological forms of spinal pain engendered by piloting helicopters were clinically studied. Lumbalgia and pathology of the dorsal and cervical spine are discussed along with their clinical and radiological signs and origins.

  3. Experimental Research on Boundary Shear Stress in Typical Meandering Channel

    Science.gov (United States)

    Chen, Kai-hua; Xia, Yun-feng; Zhang, Shi-zhao; Wen, Yun-cheng; Xu, Hua

    2018-06-01

    A novel instrument named Micro-Electro-Mechanical System (MEMS) flexible hot-film shear stress sensor was used to study the boundary shear stress distribution in the generalized natural meandering open channel, and the mean sidewall shear stress distribution along the meandering channel, and the lateral boundary shear stress distribution in the typical cross-section of the meandering channel was analysed. Based on the measurement of the boundary shear stress, a semi-empirical semi-theoretical computing approach of the boundary shear stress was derived including the effects of the secondary flow, sidewall roughness factor, eddy viscosity and the additional Reynolds stress, and more importantly, for the first time, it combined the effects of the cross-section central angle and the Reynolds number into the expressions. Afterwards, a comparison between the previous research and this study was developed. Following the result, we found that the semi-empirical semi-theoretical boundary shear stress distribution algorithm can predict the boundary shear stress distribution precisely. Finally, a single factor analysis was conducted on the relationship between the average sidewall shear stress on the convex and concave bank and the flow rate, water depth, slope ratio, or the cross-section central angle of the open channel bend. The functional relationship with each of the above factors was established, and then the distance from the location of the extreme sidewall shear stress to the bottom of the open channel was deduced based on the statistical theory.

  4. Musical Mnemonics Enhance Verbal Memory in Typically Developing Children

    Directory of Open Access Journals (Sweden)

    David Knott

    2018-05-01

    Full Text Available The purpose of this study was to compare the effects of musical mnemonics vs. spoken word in training verbal memory in children. A randomized control trial of typically-developing 9–11 year old children was conducted using the Rey Auditory Verbal Learning Test (RAVLT, a test measuring a participant's ability to recall a list of 15 words over multiple exposures. Members of the group who listened to words sung to them recalled an average of 20% more words after listening to and recalling an interference list than members of the control group who listened to the same words spoken. This difference persisted, though slightly smaller (17% when participants recalled words after a 15-min waiting period. Additionally, group participants who listened to words sung demonstrated a higher incidence of words recalled in correct serial order. Key findings were all statistically significant at the P < 0.05 level. Enhanced serial order recall points to the musical pitch/rhythm structure enhancing sequence memory as a potential mnemonic mechanism. No significant differences were found in serial position effects between groups. The findings suggest that musical mnemonic training may be more effective than rehearsal with spoken words in verbal memory learning tasks in 9–11 year olds.

  5. Physical characteristics and resistance parameters of typical urban cyclists.

    Science.gov (United States)

    Tengattini, Simone; Bigazzi, Alexander York

    2018-03-30

    This study investigates the rolling and drag resistance parameters and bicycle and cargo masses of typical urban cyclists. These factors are important for modelling of cyclist speed, power and energy expenditure, with applications including exercise performance, health and safety assessments and transportation network analysis. However, representative values for diverse urban travellers have not been established. Resistance parameters were measured utilizing a field coast-down test for 557 intercepted cyclists in Vancouver, Canada. Masses were also measured, along with other bicycle attributes such as tire pressure and size. The average (standard deviation) of coefficient of rolling resistance, effective frontal area, bicycle plus cargo mass, and bicycle-only mass were 0.0077 (0.0036), 0.559 (0.170) m 2 , 18.3 (4.1) kg, and 13.7 (3.3) kg, respectively. The range of measured values is wider and higher than suggested in existing literature, which focusses on sport cyclists. Significant correlations are identified between resistance parameters and rider and bicycle attributes, indicating higher resistance parameters for less sport-oriented cyclists. The findings of this study are important for appropriately characterising the full range of urban cyclists, including commuters and casual riders.

  6. Typical and atypical clinical presentation of uterine myomas

    Directory of Open Access Journals (Sweden)

    Wen-Hsiang Su

    2012-10-01

    Full Text Available Myoma is the most common benign neoplasm that can occur in the female reproductive system, most frequently seen in women in their 50s. Although the majority of myomas are asymptomatic, some patients have symptoms and/or signs of varying degrees. Typical myoma-related symptoms or signs include: (1 menstrual disturbances like menorrhagia, dysmenorrhea and intermenstrual bleeding, (2 pelvic pain unrelated to menstruation, (3 compression symptoms, similar to a sensation of bloatedness, urinary frequency and constipation, (4 subfertility status such as recurrent abortion, preterm labor, dystocia with an increased incidence of Cesarean section, and postpartum hemorrhage, and (5 cosmetic problems due to increased abdominal girth However, there are undoubtedly some clinical presentations secondary to uterine myomas are not so specific, such as: (1 uncommon compression-related symptoms, (2 cardiac symptom and atypical symptoms secondary to vascular involvement or dissemination, (3 abdominal symptoms mimicking pelvic carcinomatosis, (4 dyspnea, (5 pruritus, (6 hiccup or internal bleeding, and (7 vaginal protruding mass or uterine inversion. Familiarization with these symptoms and awareness of other unusual or atypical presentations of uterine myomas will remind clinical practitioners of their significance, and of the necessity of follow-up examinations and individualized management to fit the needs and childbirth desires of the patients.

  7. Typical balance exercises or exergames for balance improvement?

    Science.gov (United States)

    Gioftsidou, Asimenia; Vernadakis, Nikolaos; Malliou, Paraskevi; Batzios, Stavros; Sofokleous, Polina; Antoniou, Panagiotis; Kouli, Olga; Tsapralis, Kyriakos; Godolias, George

    2013-01-01

    Balance training is an effective intervention to improve static postural sway and balance. The purpose of the present study was to investigate the effectiveness of the Nintendo Wii Fit Plus exercises for improving balance ability in healthy collegiate students in comparison with a typical balance training program. Forty students were randomly divided into two groups, a traditional (T group) and a Nintendo Wii group (W group) performed an 8 week balance program. The "W group" used the interactive games as a training method, while the "T group" used an exercise program with mini trampoline and inflatable discs (BOSU). Pre and Post-training participants completed balance assessments. Two-way repeated measures analyses of variance (ANOVAs) were conducted to determine the effect of training program. Analysis of the data illustrated that both training program groups demonstrated an improvement in Total, Anterior-posterior and Medial Lateral Stability Index scores for both limbs. Only at the test performed in the balance board with anterior-posterior motion, the improvement in balance ability was greater in the "T group" than the "W group", when the assessment was performed post-training (p=0.023). Findings support the effectiveness of using the Nintendo Wii gaming console as a balance training intervention tool.

  8. Facilitating complex shape drawing in Williams syndrome and typical development.

    Science.gov (United States)

    Hudson, Kerry D; Farran, Emily K

    2013-07-01

    Individuals with Williams syndrome (WS) produce drawings that are disorganised, likely due to an inability to replicate numerous spatial relations between parts. This study attempted to circumvent these drawing deficits in WS when copying complex combinations of one, two and three shapes. Drawing decisions were reduced by introducing a number of facilitators, for example, by using distinct colours and including facilitatory cues on the response sheet. Overall, facilitation improved drawing in the WS group to a comparable level of accuracy as typically developing participants (matched for non-verbal ability). Drawing accuracy was greatest in both groups when planning demands (e.g. starting location, line lengths and changes in direction) were reduced by use of coloured figures and providing easily distinguished and clearly grouped facilitatory cues to form each shape. This study provides the first encouraging evidence to suggest that drawing of complex shapes in WS can be facilitated; individuals with WS might be receptive to remediation programmes for drawing and handwriting. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Typically Diverse: The Nature of Urban Agriculture in South Australia

    Directory of Open Access Journals (Sweden)

    Georgia Pollard

    2018-03-01

    Full Text Available In our visions of the future, urban agriculture has long been considered an integral part of the ‘sustainable city’. Yet urban agriculture is an incredibly diverse and variable field of study, and many practical aspects remain overlooked and understudied. This paper explores the economic sustainability of urban agriculture by focusing on the physical, practical, and economic aspects of home food gardens in South Australia. New data from the Edible Gardens project online survey is presented on a broad range of current garden setups, including a figure illustrating the statistically typical South Australian food garden. The differences between the survey data and a recent optimized garden model further highlight the gap in knowledge regarding existing home food gardens. With regard to the financial accessibility and economic sustainability of home food gardens, there is also still much more work to be done. Although saving money is a top motivation, with many survey respondents believing that they do succeed in saving money, it remains to be seen whether their current gardening practices support this aspiration. Measurement of the full costs of different gardens would allow for better predictions of whether growing food can save household’s money and under what circumstances.

  10. Dorsal anterior cingulate cortex in typically developing children: Laterality analysis

    Directory of Open Access Journals (Sweden)

    Jue Wang

    2015-10-01

    Full Text Available We aimed to elucidate the dACC laterality in typically developing children and their sex/age-related differences with a sample of 84 right-handed children (6–16 years, 42 boys. We first replicated the previous finding observed in adults that gray matter density asymmetry in the dACC was region-specific: leftward (left > right in its superior part, rightward (left < right in its inferior part. Intrinsic connectivity analysis of these regions further revealed region-specific asymmetric connectivity profiles in dACC as well as their sex and age differences. Specifically, the superior dACC connectivity with frontoparietal network and the inferior dACC connectivity with visual network are rightward. The superior dACC connectivity with the default network (lateral temporal cortex was more involved in the left hemisphere. In contrast, the inferior dACC connectivity with the default network (anterior medial prefrontal cortex was more lateralized towards the right hemisphere. The superior dACC connectivity with lateral visual cortex was more distinct across two hemispheres in girls than that in boys. This connection in boys changed with age from right-prominent to left-prominent asymmetry whereas girls developed the connection from left-prominent to no asymmetry. These findings not only highlight the complexity and laterality of the dACC but also provided insights into dynamical structure–function relationships during the development.

  11. Comparison of typical mega cities in China using emergy synthesis

    Science.gov (United States)

    Zhang, L. X.; Chen, B.; Yang, Z. F.; Chen, G. Q.; Jiang, M. M.; Liu, G. Y.

    2009-06-01

    An emergy-based comparison analysis is conducted for three typical mega cities in China, i.e., Beijing, Shanghai and Guangzhou, from 1990 to 2005 in four perspectives including emergy intensity, resource structure, environmental pressure and resource use efficiency. A new index of non-renewable emergy/money ratio is established to indicate the utilization efficiency of the non-renewable resources. The results show that for the three mega urban systems, Beijing, Shanghai and Guangzhou, the total emergy inputs were 3.76E+23, 3.54E+23, 2.52E+23 sej in 2005, of which 64.88%, 91.45% and 72.28% were imported from the outsides, respectively. As to the indicators of emergy intensity involving the total emergy use, emergy density and emergy use per cap, three cities exhibited similar overall increase trends with annual fluctuations from 1990 to 2005. Shanghai achieved the highest level of economic development and non-renewable resource use efficiency, and meanwhile, lower proportion of renewable resource use and higher environmental pressure compared to those of Beijing and Guangzhou. Guangzhou has long term sustainability considering an amount of local renewable resources used, per capita emergy used, energy consumption per unit GDP and the ratio of waste to renewable emergy. It can be concluded that different emergy-based evaluation results arise from different geographical locations, resources endowments, industrial structures and urban orientations of the concerned mega cities.

  12. A quantitative evaluation of seismic margin of typical sodium piping

    International Nuclear Information System (INIS)

    Morishita, Masaki

    1999-05-01

    It is widely recognized that the current seismic design methods for piping involve a large amount of safety margin. From this viewpoint, a series of seismic analyses and evaluations with various design codes were made on typical LMFBR main sodium piping systems. Actual capability against seismic loads were also estimated on the piping systems. Margins contained in the current codes were quantified based on these results, and potential benefits and impacts to the piping seismic design were assessed on possible mitigation of the current code allowables. From the study, the following points were clarified; 1) A combination of inelastic time history analysis and true (without margin)strength capability allows several to twenty times as large seismic load compared with the allowable load with the current methods. 2) The new rule of the ASME is relatively compatible with the results of inelastic analysis evaluation. Hence, this new rule might be a goal for the mitigation of seismic design rule. 3) With this mitigation, seismic design accommodation such as equipping with a large number of seismic supports may become unnecessary. (author)

  13. Comparative analysis on flexibility requirements of typical Cryogenic Transfer lines

    Science.gov (United States)

    Jadon, Mohit; Kumar, Uday; Choukekar, Ketan; Shah, Nitin; Sarkar, Biswanath

    2017-04-01

    The cryogenic systems and their applications; primarily in large Fusion devices, utilize multiple cryogen transfer lines of various sizes and complexities to transfer cryogenic fluids from plant to the various user/ applications. These transfer lines are composed of various critical sections i.e. tee section, elbows, flexible components etc. The mechanical sustainability (under failure circumstances) of these transfer lines are primary requirement for safe operation of the system and applications. The transfer lines need to be designed for multiple design constraints conditions like line layout, support locations and space restrictions. The transfer lines are subjected to single load and multiple load combinations, such as operational loads, seismic loads, leak in insulation vacuum loads etc. [1]. The analytical calculations and flexibility analysis using professional software are performed for the typical transfer lines without any flexible component, the results were analysed for functional and mechanical load conditions. The failure modes were identified along the critical sections. The same transfer line was then refurbished with the flexible components and analysed for failure modes. The flexible components provide additional flexibility to the transfer line system and make it safe. The results obtained from the analytical calculations were compared with those obtained from the flexibility analysis software calculations. The optimization of the flexible component’s size and selection was performed and components were selected to meet the design requirements as per code.

  14. Aqueous-chlorine leaching of typical Canadian uranium ores

    International Nuclear Information System (INIS)

    Haque, K.E.

    1982-01-01

    Laboratory-scale aqueous-chlorine leaches were conducted on quartz-pebble conglomerates, pegmatite and vein-type ores. Optimum leach temperatures, pulp density and retention times were determined. Uranium extraction of 98 per cent was obtained from the Elliot Lake, Madawaska Mines of Bancroft and Rabbit Lake ores, 96 per cent from the Key Lake ore and 86 per cent from the Agnew Lake ore. However, tailings containing 15-20 pCi g -1 of radium-226 were obtained only from the Elliot Lake and Agnew lake quartz-pebble conglomerates and Bancroft pegmatite-type ores by second-stage leaches with HCl. The second-stage leach results indicate that multistage (3 or 4) acid-chloride or salt-chloride leaches might be effective to obtain tailings containing 15-20 pCi 226 Ra g -1 from the high-grade vein-type ores. Comparative reagent-cost estimates show that the sulphuric-acid leach process is far less expensive than aqueous chlorine leaching. Nevertheless, only the aqueous chlorine and acid-chloride leaches in stages are effective in producing tailings containing 15-20 pCi 226 Ra g -1 from the typical Canadian uranium ores. (Auth.)

  15. Typical intellectual engagement and cognition in old age.

    Science.gov (United States)

    Dellenbach, Myriam; Zimprich, Daniel

    2008-03-01

    Typical Intellectual Engagement (TIE) comprises the preference to engage in cognitively demanding activities and has been proposed as a potential explanatory variable of individual differences in cognitive abilities. Little is known, however, about the factorial structure of TIE, its relations to socio-demographic variables, and its influence on intellectual functioning in old age. In the present study, data of 364 adults (65-81 years) from the Zurich Longitudinal Study on Cognitive Aging (ZULU) were used to investigate the factorial structure of TIE and to examine the hypothesis that TIE is associated more strongly with crystallized intelligence than with fluid intelligence in old age. A measurement model of a second order factor based on a structure of four correlated first order factors (Reading, Problem Solving, Abstract Thinking, and Intellectual Curiosity) evinced an excellent fit. After controlling for age, sex, and formal education, TIE was more strongly associated with crystallized intelligence than with fluid intelligence, comparable to results in younger persons. More detailed analyses showed that this association is mostly defined via Reading and Intellectual Curiosity.

  16. The use of conjunctions by children with typical language development.

    Science.gov (United States)

    Glória, Yasmin Alves Leão; Hanauer, Letícia Pessota; Wiethan, Fernanda Marafiga; Nóro, Letícia Arruda; Mota, Helena Bolli

    2016-07-04

    To investigate the use of conjunctions in the spontaneous speech of three years old children with typical language development, who live in Santa Maria - RS. 45 children, aged 3:0;0 - 3:11;29 (years:months;days) from the database of the Center for the Study of Language and Speech (CELF) participated of this study. The spontaneous speech of each child was transcribed and followed by analysis of the samples to identify the types of conjunctions for each age group. The samples were statistically analyzed using the R software that allowed the evaluation of the number and type of conjunctions used in each age group by comparing them with each other. The data indicated that the higher the age of the child, the greater the number of types of conjunctions used by them. The comparison between age groups showed significant differences when comparing the average number of conjunctions per age group, as well as for additive conjunctions and subordinating conjunctions. At age of three the children begin to develop the grammatical use of conjunctions, early appearing additive, adversative and explanatory coordinating conjunctions, and at 3:6 they are able to use the most complex conjunctions, as subordinating conjunctions.

  17. Piloted Aircraft Environment Simulation Techniques

    Science.gov (United States)

    1978-04-01

    raS’I.Al. lIIf~iiI~.1 labL. lot. Rolmotion -oft. skylicav - ow d Roll rMotion -oft Skylicape - Off Fig 6 a A Effect of roll motion and akyscape, an msatwntn...greater realism and pilot involvement than ground based simu- lation, it still lacks some of the pilot motivating factors of actual combat. Flight

  18. Active Job Monitoring in Pilots

    Science.gov (United States)

    Kuehn, Eileen; Fischer, Max; Giffels, Manuel; Jung, Christopher; Petzold, Andreas

    2015-12-01

    Recent developments in high energy physics (HEP) including multi-core jobs and multi-core pilots require data centres to gain a deep understanding of the system to monitor, design, and upgrade computing clusters. Networking is a critical component. Especially the increased usage of data federations, for example in diskless computing centres or as a fallback solution, relies on WAN connectivity and availability. The specific demands of different experiments and communities, but also the need for identification of misbehaving batch jobs, requires an active monitoring. Existing monitoring tools are not capable of measuring fine-grained information at batch job level. This complicates network-aware scheduling and optimisations. In addition, pilots add another layer of abstraction. They behave like batch systems themselves by managing and executing payloads of jobs internally. The number of real jobs being executed is unknown, as the original batch system has no access to internal information about the scheduling process inside the pilots. Therefore, the comparability of jobs and pilots for predicting run-time behaviour or network performance cannot be ensured. Hence, identifying the actual payload is important. At the GridKa Tier 1 centre a specific tool is in use that allows the monitoring of network traffic information at batch job level. This contribution presents the current monitoring approach and discusses recent efforts and importance to identify pilots and their substructures inside the batch system. It will also show how to determine monitoring data of specific jobs from identified pilots. Finally, the approach is evaluated.

  19. Aging Management Plan for a Typical Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ebrahimi, Mahsa; Nazififard, Mohammad; Suh, Kune Y. [Seoul National University, Seoul (Korea, Republic of)

    2012-05-15

    Development of an aging management plan (AMP) is a crucial contributor to maintaining the reactor safety and controlling the risk of degradation of the concrete reactor building of a nuclear power plant. The design, operation and utilization of a research reactor (RR) fundamentally differ from those of power reactors. The AMP should nonetheless be present on account of radioactive materials and radiation risks involved. This is mainly because the RR is deemed to be used as an experiment itself or to conduct separate experiments during its operation. The AMP aims to determine the requisites for specific structural concrete components of the reactor building that entail regular inspections and maintenance to ensure safe and reliable operation of the plant. The safety of a RR necessitates the provision which is made in its design to facilitate aging management. Aging management of RR's structures is one of the vital factors to safety, to ensure continued adequacy of the safety level, reliable operation of the reactor, and compliance with the operational limits and conditions.Moreover, engineering systems should be qualified to meet the functional requirements for which they were designed with aging and environmental conditions for all situations and at all times taken into account. This study aims to present an integrated methodology for the application of an AMP for the concrete of the reactor building of a typical RR. For the purpose of safety analysis, geometry and ambient conditions were taken from a 5 MW pool-type, light-water moderated, heterogeneous, solid fuel RR in which the water is also used for cooling and shielding (Fig. 1). The reactor core is immersed in either section of a two-section concrete pool filled with water. This paper makes available background information regarding the document and the strategy developed to manage potential degradation of the reactor building concrete as well as specific programs and preventive and corrective

  20. Typical tumors of the petrous bone; Typische Tumoren des Felsenbeins

    Energy Technology Data Exchange (ETDEWEB)

    Ahlhelm, F.; Mueller, U. [Kantonsspital Baden AG, Abteilung fuer Neuroradiologie, Institut fuer Radiologie, Baden (Switzerland); Ulmer, S. [Medizinisch-Radiologisches Institut, Zuerich (Switzerland)

    2014-04-15

    In the region of the petrous bone, inner acoustic canal and cerebellopontine angle, a variety of different tissues can be found, such as bony, epithelial, neural and vascular structures. Tumorous or tumor-like lesions, vascular or bony malformations or other pathologies can therefore be found in all of these areas. We discuss various frequently occurring tumorous or tumor-like pathologies including congential lesions, such as mucoceles, inflammatory disorders including osteomyelitis, pseudotumors and Wegener's granulomatosis. Benign non-neoplastic lesions, such as cholesteatoma, cholesterol granuloma, epidermoid and benign neoplastic tumors, such as the most commonly found vestibular schwannoma, meningeoma, paraganglioma, vascular pathologies and finally malignant lesions, such as metastasis, chordoma or chondrosarcoma and endolymphatic sac tumor (ELST) are also discussed. The emphasis of this article is on the appearance of these entities in computed tomography (CT) and more so magnetic resonance imaging (MRI), it provides key facts and typical images and discusses possibilities how to distinguish these pathologies. (orig.) [German] In der Region des Felsenbein, inneren Gehoerkanals und Kleinhirnbrueckenwinkels findet sich eine Vielzahl an unterschiedlichen Gewebearten inklusive knoechernes, epitheliales, nervales und vaskulaeres Gewebe. Tumoren oder tumoraehnliche Laesionen, ossaere oder vaskulaere Pathologien koennen entsprechend dort gefunden werden. Wir diskutieren verschiedene Tumoren oder tumoraehnliche Pathologien inklusive angeborene Laesionen wie Muko- und Meningozelen, entzuendliche Veraenderungen wie die Osteomyelitis, Pseudotumoren, die Wegener-Granulomatose, nichtneoplastische Tumoren wie das Epidermoid, Cholesteatom oder Cholesterolgranulom und gutartige neoplastische Tumoren wie das am haeufigsten zu findende Vestibularisschwannom, das Paragangliom und das Meningeom, Gefaessprozesse/-pathologien und schliesslich maligne Laesionen wie Metastasen

  1. Thermal properties of typical chernozems in Kursk Oblast

    Science.gov (United States)

    Arkhangel'skaya, T. A.; Velichenko, M. V.; Tikhonravova, P. I.

    2016-10-01

    Thermal diffusivity and heat capacity of virgin and plowed heavy loamy typical chernozems of Kursk oblast were studied. Thermal diffusivity was determined in the course of step-by-step drying of the initially capillary-saturated samples to the air-dry state. Specific heat capacity was determined for absolutely dry samples. Volumetric heat capacity was calculated according to the de Vries equation. Thermal diffusivity varied within the ranges of (1.15-3.46) × 10-7 m2/s in the Ap horizon, (1.14-3.35) × 10-7 m2/s in the A1 horizon, (1.49-3.70) × 10-7 m2/s in the AB horizon, (1.49-3.91) × 10-7 m2/s in the B1 horizon, and (1.60-3.80) × 10-7 m2/s in the Bca horizon. The thermal diffusivity vs. water content dependencies had distinct maximums and were flattened in the range of low water contents. The maximums were most pronounced for the mineral B1 and Bca horizons; for the A1 and Ap horizons, the curves were rather S-shaped. Volumetric heat capacity of the air-dry soils varied from 0.96 J/(cm3 K) in the A1 horizon to 1.31 J/(cm3 K) in the Bca horizon; in the state of capillary saturation, it varied from 2.79 J/(cm3 K) in the A1 horizon to 3.28 J/(cm3 K) in the Bca horizon. Thermal properties of topsoil horizons were higher in the plowed chernozem compared with the virgin chernozem, which is explained by an increase in the bulk density and a decrease in the organic matter content in the plowed soil.

  2. Integrated SNG Production in a Typical Nordic Sawmill

    Directory of Open Access Journals (Sweden)

    Sennai Mesfun

    2016-04-01

    Full Text Available Advanced biomass-based motor fuels and chemicals are becoming increasingly important to replace fossil energy sources within the coming decades. It is likely that the new biorefineries will evolve mainly from existing forest industry sites, as they already have the required biomass handling infrastructure in place. The main objective of this work is to assess the potential for increasing the profit margin from sawmill byproducts by integrating innovative downstream processes. The focus is on the techno-economic evaluation of an integrated site for biomass-based synthetic natural gas (bio-SNG production. The option of using the syngas in a biomass-integrated gasification combined cycle (b-IGCC for the production of electricity (instead of SNG is also considered for comparison. The process flowsheets that are used to analyze the energy and material balances are modelled in MATLAB and Simulink. A mathematical process integration model of a typical Nordic sawmill is used to analyze the effects on the energy flows in the overall site, as well as to evaluate the site economics. Different plant sizes have been considered in order to assess the economy-of-scale effect. The technical data required as input are collected from the literature and, in some cases, from experiments. The investment cost is evaluated on the basis of conducted studies, third party supplier budget quotations and in-house database information. This paper presents complete material and energy balances of the considered processes and the resulting process economics. Results show that in order for the integrated SNG production to be favored, depending on the sawmill size, a biofuel subsidy in the order of 28–52 €/MWh SNG is required.

  3. Ballistic Characterization Of A Typical Military Steel Helmet

    Directory of Open Access Journals (Sweden)

    Mohamed Ali Maher

    2017-08-01

    Full Text Available In this study the ballistic limit of a steel helmet against a FMJ 919 mm caliber bullet is estimated. The helmet model is the typical polish helmet wz.31.The helmet material showed high strength low alloy steel material of 0.28 carbon content and 9.125 kgm2 areal density. The tensile test according to ASTM E8 showed a tensile strength of 1236.4 MPa .The average hardness value was about HV550. First shooting experiment has been executed using a 9 mm pistol based on 350 ms muzzle velocity at 5m against the simply supported helmet complete penetrations rose in this test were in the form of cracks on the helmet surface and partial penetrations were in the form of craters on the surface whose largest diameter and depth were 43 mm and 20.2 mm consequently .The second experiment was on a rifled gun arrangement 13 bullets of 919 mm caliber were shot on the examined simply supported steel helmet at a zero obliquity angle at different velocities to determine the ballistic limit velocity V50 according to MIL-STD-662F. Three major outcomes were revealed 1 the value V50 which found to be about 390 ms is higher than the one found in literature 360 ms German steel helmet model 1A1. 2 The smallest the standard deviation of the mixed results zone data the most accurate the ballistic limit is. 3Similar to the performance of blunt-ended projectiles impacting overmatching targets tD near 11 or larger It was found that the dominating failure mode of the steel helmet stuck by a hemispherical-nose projectile was plugging mode despite of having tD ratio of about 19 undermatching.

  4. Describing Speech Usage in Daily Activities in Typical Adults.

    Science.gov (United States)

    Anderson, Laine; Baylor, Carolyn R; Eadie, Tanya L; Yorkston, Kathryn M

    2016-01-01

    "Speech usage" refers to what people want or need to do with their speech to meet communication demands in life roles. The purpose of this study was to contribute to validation of the Levels of Speech Usage scale by providing descriptive data from a sample of adults without communication disorders, comparing this scale to a published Occupational Voice Demands scale and examining predictors of speech usage levels. This is a survey design. Adults aged ≥25 years without reported communication disorders were recruited nationally to complete an online questionnaire. The questionnaire included the Levels of Speech Usage scale, questions about relevant occupational and nonoccupational activities (eg, socializing, hobbies, childcare, and so forth), and demographic information. Participants were also categorized according to Koufman and Isaacson occupational voice demands scale. A total of 276 participants completed the questionnaires. People who worked for pay tended to report higher levels of speech usage than those who do not work for pay. Regression analyses showed employment to be the major contributor to speech usage; however, considerable variance left unaccounted for suggests that determinants of speech usage and the relationship between speech usage, employment, and other life activities are not yet fully defined. The Levels of Speech Usage may be a viable instrument to systematically rate speech usage because it captures both occupational and nonoccupational speech demands. These data from a sample of typical adults may provide a reference to help in interpreting the impact of communication disorders on speech usage patterns. Copyright © 2016 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  5. Gender-typical olfactory regulation of sexual behavior in goldfish

    Directory of Open Access Journals (Sweden)

    Makito eKobayashi

    2014-04-01

    Full Text Available It is known that olfaction is essential for the occurrence of sexual behavior in male goldfish. Sex pheromones from ovulatory females elicit male sexual behavior, chasing and sperm releasing act. In female goldfish, ovarian prostaglandin F2α (PGF elicits female sexual behavior, egg releasing act. It has been considered that olfaction does not affect sexual behavior in female goldfish. In the present study, we reexamined the involvement of olfaction in sexual behavior of female goldfish. Olfaction was blocked in male and female goldfish by two methods: nasal occlusion (NO which blocks the reception of olfactants, and olfactory tract section (OTX which blocks transmission of olfactory information from the olfactory bulb to the telencephalon. Sexual behavior of goldfish was induced by administration of PGF to females, an established method for inducing goldfish sexual behavior in both sexes. Sexual behavior in males was suppressed by NO and OTX as previously reported because of lack of pheromone stimulation. In females, NO suppressed sexual behavior but OTX did not affect the occurrence of sexual behavior. Females treated with both NO and OTX performed sexual behavior normally. These results indicate that olfaction is essential in female goldfish to perform sexual behavior as in males but in a different manner. The lack of olfaction in males causes lack of pheromonal stimulation, resulting in no behavior elicited. Whereas the results of female experiments suggest that lack of olfaction in females causes strong inhibition of sexual behavior mediated by the olfactory pathway. Olfactory tract section is considered to block the pathway and remove this inhibition, resulting in the resumption of the behavior. By subtract sectioning of the olfactory tract, it was found that this inhibition was mediated by the medial olfactory tracts, not the lateral olfactory tracts. Thus, it is concluded that goldfish has gender-typical olfactory regulation for sexual

  6. Toronto hybrid taxi pilot

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, M. [CrossChasm Technologies, Cambridge, ON (Canada); Marans, B. [Toronto Atmospheric Fund, ON (Canada)

    2009-10-15

    This paper provided details of a hybrid taxi pilot program conducted to compare the on-road performance of Toyota Camry hybrid vehicles against conventional vehicles over a 1-year period in order to determine the business case and air emission reductions associated with the use of hybrid taxi cabs. Over 750,000 km worth of fuel consumption was captured from 10 Toyota Camry hybrids, a Toyota Prius, and 5 non-hybrid Camry vehicles over an 18-month period. The average real world fuel consumption for the taxis demonstrated that the Toyota Prius has the lowest cost of ownership, while the non-hybrid Camry has the highest cost of ownership. Carbon dioxide (CO{sub 2}) reductions associated with the 10 Camry hybrid taxis were calculated at 236 tonnes over a 7-year taxi service life. Results suggested that the conversion of Toronto's 5680 taxis would yield annual CO{sub 2} emission reductions of over 19,000 tonnes. All hybrid purchasers identified themselves as highly likely to purchase a hybrid again. 5 tabs., 9 figs.

  7. Fitzmaurice Voicework Pilot Study.

    Science.gov (United States)

    Watson, Lynn; Nayak, Sadhana

    2015-11-01

    A repeated-measures pilot study was used to investigate acoustic changes in the voices of participants in a Fitzmaurice Voicework (FV) teacher certification program. Maximum phonation time (MPT) was also measured. Eleven participants with no reported voice problems were studied. Pretraining and posttraining recordings were made of each participant. Measures of MPT were made, and the recordings were analyzed for jitter, shimmer, and noise-to-harmonics ratio (NHR). The measure of effect size for MPT was moderate, and there was an overall increase in MPT from pretraining to posttraining, with 70% of participants showing an increase in MPT. The measure of effect sizes for jitter, shimmer, and NHR were small, with measurements showing no significant changes from pretraining to posttraining. There were indications that FV training may have positive outcomes for actors and professional voice users, particularly in increasing MPT. Further studies with larger subject groups are needed to investigate the significance of the increase in MPT noted in this study and to test whether FV training can help to lower rates of shimmer and jitter. Copyright © 2015 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  8. Toronto hybrid taxi pilot

    International Nuclear Information System (INIS)

    Stevens, M.; Marans, B.

    2009-10-01

    This paper provided details of a hybrid taxi pilot program conducted to compare the on-road performance of Toyota Camry hybrid vehicles against conventional vehicles over a 1-year period in order to determine the business case and air emission reductions associated with the use of hybrid taxi cabs. Over 750,000 km worth of fuel consumption was captured from 10 Toyota Camry hybrids, a Toyota Prius, and 5 non-hybrid Camry vehicles over an 18-month period. The average real world fuel consumption for the taxis demonstrated that the Toyota Prius has the lowest cost of ownership, while the non-hybrid Camry has the highest cost of ownership. Carbon dioxide (CO 2 ) reductions associated with the 10 Camry hybrid taxis were calculated at 236 tonnes over a 7-year taxi service life. Results suggested that the conversion of Toronto's 5680 taxis would yield annual CO 2 emission reductions of over 19,000 tonnes. All hybrid purchasers identified themselves as highly likely to purchase a hybrid again. 5 tabs., 9 figs.

  9. The Marcoule pilot plant

    International Nuclear Information System (INIS)

    Faugeras, P.; Calame Longjean, A.; Le Bouhellec, J.; Revol, G.

    1986-06-01

    The Marcoule spent fuel reprocessing pilot facility was built in 1960-1961 for extended testing of the PUREX process with various types of fuel under conditions similar to those encountered in a production plant. Extensive modification work was undertaken on the facility in 1983 in the scope of the TOR project, designed with the following objectives: - increase the throughput capacity to at least 5 metric tons of PHENIX equivalent fuel per year, - extend equipment and process R and D capability, - improve job safety by maximum use of remote handling facilities, - maximize waste conditioning treatments to produce waste forms suitable for direct storage, - provide a true industrial process demonstration in continuous operation under centralized control using computerized procedures. The redesigned plant is scheduled to begin operation during the second half of 1986. The proximity of the Industrial Prototypes Service and the ATALANTE radiochemical research laboratory scheduled to begin operation in 1990, will provide a synergistic environment in which R and D program may be carried out under exceptional conditions

  10. Roll paper pilot. [mathematical model for predicting pilot rating of aircraft in roll task

    Science.gov (United States)

    Naylor, F. R.; Dillow, J. D.; Hannen, R. A.

    1973-01-01

    A mathematical model for predicting the pilot rating of an aircraft in a roll task is described. The model includes: (1) the lateral-directional aircraft equations of motion; (2) a stochastic gust model; (3) a pilot model with two free parameters; and (4) a pilot rating expression that is a function of rms roll angle and the pilot lead time constant. The pilot gain and lead time constant are selected to minimize the pilot rating expression. The pilot parameters are then adjusted to provide a 20% stability margin and the adjusted pilot parameters are used to compute a roll paper pilot rating of the aircraft/gust configuration. The roll paper pilot rating was computed for 25 aircraft/gust configurations. A range of actual ratings from 2 to 9 were encountered and the roll paper pilot ratings agree quite well with the actual ratings. In addition there is good correlation between predicted and measured rms roll angle.

  11. Response of Maize Plant to Phosphorus Fertilization on Typic Distrudepts

    Directory of Open Access Journals (Sweden)

    Antonius Kasno

    2009-05-01

    Full Text Available On the acid soil, phosphorus nutrients become critical for agricultural crops growth. At the present, price of fertilizers significantly increase and fertilizers are not available. These conditions can affect on soil productivity and crop production. The objective of these research were to study the response of maize (Zea mays L. to phosphate fertilizers on Inceptisol. The research was conducted in Cicadas Village on Typic Dystrudept. Experiment was conducted in a randomized completely block design, with 8 treatments and three replications. Treatments consisted of 6 dosages of P fertilizers, which were P source is SP-36 WIKA Agro 0, 10, 20, 40, 60 and 80 kg ha-1. SP-36 and Tunisia rock phosphate (40 kg P ha-1 were used for standard. Pioneer 12 variety of maized was used as an indicator. Plot size was 5 m x 6 m and the maize was planting with distance of 75 cm x 20 cm with one seed per hole. The results showed that organic C and N, P (extracted by Bray 1, K and CEC on the soil were low. Phosphate fertilizers significantly increased which was P extracted by HCl 25% from 24 to 67 mg P 100 g-1 soil and which were extracted by Bray 1 increased from 0,87 to 63.31 mg P kg-1 soil. Phosphate fertilizers significantly increased plant height from 175.2 cm become to 221.1 cm. Plant height of maize using SP-36 WIKA Agro fertilizer (210.6 cm was similar to plant heigh using SP-36 fertilizer (213.4 cm but less height from Tunisia rock phosphate. The yield of maize on SP-36 WIKA Agro (4.94 t ha-1 were linely higher than SP-36 (4.69 t ha-1, significantly was higher than that of Tunisia rock phosphate. Maximum dosage of SP-36 fertilizer was 66.67 kg P ha-1, and optimum dosage was 42 kg P ha-1. Value of Relative Agronomic Effectiveness SP-36 WIKA Agro fertilizer was heigher than SP-36.

  12. [Investigation of typical melamine urinary stones using infrared spectra].

    Science.gov (United States)

    Si, Min-Zhen; Li, Qing-Yun; Liu, Ren-Ming; Kang, Yi-Pu; Wang, Kun-Hua; Zhang, Zhi-Guo

    2010-02-01

    A typical melamine kidney stone confirmed by some medicine expert was collected from the first people's hospital of Yunnan. The kidney stone was adequately determined by PE corporation spectra 100(with resolution of 1 cm(-1)). The stone samples for FTIR analysis were prepared using the KBr pellet technique, where 2 mg of the pretreated stone powder was mixed with 200 mg of analytical grade KBr using an agate pestle and mortar. The digital spectrum was then scanned in the mid-infrared region from 4 000 to 400 cm(-1) at room temperature. The appearing bands between 4 000 and 2 000 cm(-1) were 3 487, 3 325, 3 162 and 2 788 cm(-1), those between 1 700 and 1 000 cm(-1) were 1 694, 1 555, 1 383, 1 340, 1 189 and 1 122 cm(-1), and those between 1 000 and 400 cm(-1) were 993, 782, 748, 709, 624, 585, 565 and 476 cm(-1). It was found that the main constituent of calculi showed few comparability with cat kidney stone, which was from cats that died after consuming the contaminated food, and confirmed that these deposits were primarily composed of melamine and cyanuric acid compared to the IR spectra of calculi in literature. It was also found that the main constituent of calculi showed few comparability with popular kidney stone by comparison with the IR spectra of calculi in literature. The spectrum of calculi was 50% respectively similar with melamine and uric acid as compared with the IR spectrum. It was found that the main constituent of calculi was melamine itself and uric acid as compared with the IR spectra of calculi and melamine: (1 : 1), because the spectrum of calculi was 83. 3% similar to melamine and uric acid (1 : 1). The appearing bands of melamine and uric acid (1 : 1) between 4 000 and 2 000 cm(-1) were 3 469, 3 419, 3 333, 3 132, 3 026, 2 827 cm(-1), those between 1 700 and 1 000 cm(-1) were 1 696, 1 656, 1 555, 1 489, 1 439, 1 350, 1 311, 1 198, 1 124 and 1 028 cm(-1), and those between 1 000 and 400 cm(-1) were 993, 878, 814, 784, 745, 708, 619, 577 and

  13. Energy-Performance-Based Design-Build Process: Strategies for Procuring High-Performance Buildings on Typical Construction Budgets: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Scheib, J.; Pless, S.; Torcellini, P.

    2014-08-01

    NREL experienced a significant increase in employees and facilities on our 327-acre main campus in Golden, Colorado over the past five years. To support this growth, researchers developed and demonstrated a new building acquisition method that successfully integrates energy efficiency requirements into the design-build requests for proposals and contracts. We piloted this energy performance based design-build process with our first new construction project in 2008. We have since replicated and evolved the process for large office buildings, a smart grid research laboratory, a supercomputer, a parking structure, and a cafeteria. Each project incorporated aggressive efficiency strategies using contractual energy use requirements in the design-build contracts, all on typical construction budgets. We have found that when energy efficiency is a core project requirement as defined at the beginning of a project, innovative design-build teams can integrate the most cost effective and high performance efficiency strategies on typical construction budgets. When the design-build contract includes measurable energy requirements and is set up to incentivize design-build teams to focus on achieving high performance in actual operations, owners can now expect their facilities to perform. As NREL completed the new construction in 2013, we have documented our best practices in training materials and a how-to guide so that other owners and owner's representatives can replicate our successes and learn from our experiences in attaining market viable, world-class energy performance in the built environment.

  14. 14 CFR 121.437 - Pilot qualification: Certificates required.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot qualification: Certificates required... Pilot qualification: Certificates required. (a) No pilot may act as pilot in command of an aircraft (or... pilots) unless he holds an airline transport pilot certificate and an appropriate type rating for that...

  15. 49 CFR 381.400 - What is a pilot program?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false What is a pilot program? 381.400 Section 381.400... PILOT PROGRAMS Initiation of Pilot Programs § 381.400 What is a pilot program? (a) A pilot program is a... that would be subject to the regulations. (b) During a pilot program, the participants would be given...

  16. 75 FR 53007 - Gulf Opportunity Pilot Loan Program (GO Loan Pilot)

    Science.gov (United States)

    2010-08-30

    ... SMALL BUSINESS ADMINISTRATION Gulf Opportunity Pilot Loan Program (GO Loan Pilot) AGENCY: U.S...'s GO Loan Pilot until September 30, 2011. Due to the scope and magnitude of the devastation to... streamlined and centralized loan processing available through the GO Loan Pilot to small businesses in the...

  17. 77 FR 61721 - Pilot, Flight Instructor, and Pilot School Certification; Technical Amendment

    Science.gov (United States)

    2012-10-11

    ...-26661; Amdt. No. 61-129A] RIN 2120-AI86 Pilot, Flight Instructor, and Pilot School Certification... revise the training, qualification, certification, and operating requirements for pilots, flight instructors, ground instructors, and pilot schools. A portion of the codified text was inadvertently deleted...

  18. 76 FR 60960 - Gulf Opportunity Pilot Loan Program (GO Loan Pilot)

    Science.gov (United States)

    2011-09-30

    ... SMALL BUSINESS ADMINISTRATION Gulf Opportunity Pilot Loan Program (GO Loan Pilot) AGENCY: U.S.... SUMMARY: This notice announces the extension of SBA's GO Loan Pilot, with modifications, until December 31... processing available through the GO Loan Pilot to small businesses in the eligible parishes/counties through...

  19. Macroscopic mass and energy balance of a pilot plant anaerobic bioreactor operated under thermophilic conditions.

    Science.gov (United States)

    Espinosa-Solares, Teodoro; Bombardiere, John; Chatfield, Mark; Domaschko, Max; Easter, Michael; Stafford, David A; Castillo-Angeles, Saul; Castellanos-Hernandez, Nehemias

    2006-01-01

    Intensive poultry production generates over 100,000 t of litter annually in West Virginia and 9 x 10(6) t nationwide. Current available technological alternatives based on thermophilic anaerobic digestion for residuals treatment are diverse. A modification of the typical continuous stirred tank reactor is a promising process being relatively stable and owing to its capability to manage considerable amounts of residuals at low operational cost. A 40-m3 pilot plant digester was used for performance evaluation considering energy input and methane production. Results suggest some changes to the pilot plant configuration are necessary to reduce power consumption although maximizing biodigester performance.

  20. Sunglass Filter Transmission and Its Operational Effect in Solar Protection for Civilian Pilots.

    Science.gov (United States)

    Chorley, Adrian C; Lyachev, Andrey; Higlett, Michael P; Khazova, Marina; Benwell, Martin J; Evans, Bruce J W

    2016-05-01

    The ocular effects of excess solar radiation exposure are well documented. Recent evidence suggests that ocular ultraviolet radiation (UVR) exposure to professional pilots may fall outside international guideline limits unless eye protection is used. Nonprescription sunglasses should be manufactured to meet either international or national standards. The mean increase in UVR and blue light hazards at altitude has been quantified and the aim of this research was to assess the effectiveness of typical pilot sunglasses in reducing UVR and blue light hazard exposure in flight. A series of sunglass filter transmittance measurements were taken from personal sunglasses (N = 20) used by pilots together with a series of new sunglasses (N = 18). All nonprescription sunglasses measured conformed to international standards for UVR transmittance and offered sufficient UVR protection for pilots. There was no difference between right and left lenses or between new and used sunglasses. All sunglasses offered sufficient attenuation to counter the mean increase in blue light exposure that pilots experience at altitude, although used sunglasses with scratched lenses were marginally less effective. One pair of prescription sunglasses offered insufficient UVR attenuation for some flights, but would have met requirements of international and national standards for UV-A transmittance. This was likely due to insufficient UVR blocking properties of the lens material. Lenses manufactured to minimally comply with standards for UVR transmittance could result in excess UVR exposure to a pilot based on in-flight irradiance data; an additional requirement of less than 10% transmittance at 380 nm is recommended.

  1. Development and evaluation of an intervention aiming to reduce fatigue in airline pilots: design of a randomised controlled trial.

    Science.gov (United States)

    van Drongelen, Alwin; van der Beek, Allard J; Hlobil, Hynek; Smid, Tjabe; Boot, Cécile R L

    2013-08-26

    A considerable percentage of flight crew reports to be fatigued regularly. This is partly caused by irregular and long working hours and the crossing of time zones. It has been shown that persistent fatigue can lead to health problems, impaired performance during work, and a decreased work-private life balance. It is hypothesized that an intervention consisting of tailored advice regarding exposure to daylight, optimising sleep, physical activity, and nutrition will lead to a reduction of fatigue in airline pilots compared to a control group, which receives a minimal intervention with standard available information. The study population will consist of pilots of a large airline company. All pilots who posses a smartphone or tablet, and who are not on sick leave for more than four weeks at the moment of recruitment, will be eligible for participation.In a two-armed randomised controlled trial, participants will be allocated to an intervention group that will receive the tailored advice to optimise exposure to daylight, sleep, physical activity and nutrition, and a control group that will receive standard available information. The intervention will be applied using a smartphone application and a website, and will be tailored on flight- and participant-specific characteristics. The primary outcome of the study is perceived fatigue. Secondary outcomes are need for recovery, duration and quality of sleep, dietary and physical activity behaviours, work-private life balance, general health, and sickness absence. A process evaluation will be conducted as well. Outcomes will be measured at baseline and at three and six months after baseline. This paper describes the development of an intervention for airline pilots, consisting of tailored advice (on exposure to daylight and sleep-, physical activity, and nutrition) applied into a smartphone application. Further, the paper describes the design of the randomised controlled trial evaluating the effect of the intervention on

  2. Regional ventricular performance and exercise training in children and young adults after repair of tetralogy of Fallot: randomized controlled pilot study.

    Science.gov (United States)

    Duppen, Nienke; Geerdink, Lianne M; Kuipers, Irene M; Bossers, Sjoerd S M; Koopman, Laurens P; van Dijk, Arie P J; Roos-Hesselink, Jolien W; De Korte, Chris L; Helbing, Willem A; Kapusta, Livia

    2015-04-01

    Public-health guidelines recommend patients with congenital heart disease to exercise. Studies have shown that patients with congenital heart disease can improve physical exercise capacity. The effect of training on regional ventricular performance has hardly been studied. We performed a pilot study to assess whether an exercise training program would result in adverse changes of regional ventricular performance in patients with corrected tetralogy of Fallot. Multicenter prospective randomized controlled pilot study in patients with tetralogy of Fallot aged 10 to 25 years. A 12-week standardized aerobic dynamic exercise training program (3 one-hour sessions per week) was used. Pre- and post-training cardiopulmonary exercise tests, MRI, and echocardiography, including tissue-Doppler imaging, were performed. Patients were randomized to the exercise group (n=28) or control group (n=20). One patient in the exercise group dropped out. Change in tissue-Doppler imaging parameters was similar in the exercise group and control group (change in right ventricle free wall peak velocity E' exercise group, 0.8±2.6 cm/s; control group, 0.9±4.1; peak velocity A' exercise group, 0.4±2.4 m/s; control group 4.6±18.1 cm/s). This randomized controlled pilot study provides preliminary data suggesting that regional ventricular performance is well maintained during 3-month aerobic dynamic exercise training in children and young adults with repaired tetralogy of Fallot. This information might help patients adhere to current public-health guidelines. URL: http//:www.trialregister.nl. Unique identifier: NTR2731. © 2015 American Heart Association, Inc.

  3. 76 FR 56262 - Community Advantage Pilot Program

    Science.gov (United States)

    2011-09-12

    ... SMALL BUSINESS ADMINISTRATION [Docket No. SBA 2011-0003] Community Advantage Pilot Program AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of change to Community Advantage Pilot... Community Advantage Pilot Program. In that notice, SBA modified or waived as appropriate certain regulations...

  4. 77 FR 58208 - Airport Privatization Pilot Program

    Science.gov (United States)

    2012-09-19

    ... Privatization Pilot Program AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of receipt of... International Airport, San Juan, Puerto Rico (SJU) in the Airport Privatization Pilot Program and has determined....S.C. Section 47134 establishes an airport privatization pilot program and authorizes the Department...

  5. 75 FR 473 - Community Express Pilot Program

    Science.gov (United States)

    2010-01-05

    ... SMALL BUSINESS ADMINISTRATION Community Express Pilot Program AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of extension of the Community Express Pilot Program. SUMMARY: This notice extends the Community Express Pilot Program in its current form through December 31, 2010. Based upon the...

  6. 75 FR 80561 - Community Express Pilot Program

    Science.gov (United States)

    2010-12-22

    ... SMALL BUSINESS ADMINISTRATION Community Express Pilot Program AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of short-term extension and termination of the Community Express Pilot Program. SUMMARY: This notice announces the termination of the Community Express Pilot Program following a...

  7. 75 FR 68018 - Airport Privatization Pilot Program

    Science.gov (United States)

    2010-11-04

    ... Privatization Pilot Program AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Receipt and... preliminary application for participation in the airport privatization pilot program received under 49 U.S.C... final application to the FAA for exemption under the pilot program. 49 U.S.C. Section 47134 establishes...

  8. 75 FR 39091 - Airport Privatization Pilot Program

    Science.gov (United States)

    2010-07-07

    ... Privatization Pilot Program AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Receipt and... application for participation in the airport privatization pilot program received under 49 U.S.C. 47134. The... application to the FAA for exemption under the pilot program. 49 U.S.C. 47134 establishes an airport...

  9. 78 FR 50399 - Spectrum Monitoring Pilot Program

    Science.gov (United States)

    2013-08-19

    ... 130809703-3703-01] RIN 0660-XC007 Spectrum Monitoring Pilot Program AGENCY: National Telecommunications and... National Telecommunications and Information Administration (NTIA) to design and conduct a pilot program to... investment for a two-year pilot program to determine the benefits of an automated spectrum measurement and...

  10. 28 CFR 11.2 - Pilot program.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Pilot program. 11.2 Section 11.2 Judicial... Pilot program. The Assistant Attorney General for Administration, in consultation with the Executive Office for United States Attorneys, shall designate the districts that will participate in the pilot...

  11. 75 FR 1591 - Green Technology Pilot Program

    Science.gov (United States)

    2010-01-12

    ... DEPARTMENT OF COMMERCE Patent and Trademark Office Green Technology Pilot Program ACTION: Proposed... methods: E-mail: [email protected] . Include A0651-0062 Green Technology Pilot Program [email protected] in... (USPTO) is implementing a streamlined examination pilot program for patent applications pertaining to...

  12. 75 FR 39090 - Airport Privatization Pilot Program

    Science.gov (United States)

    2010-07-07

    ... Privatization Pilot Program AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Receipt and... pilot program received under 49 U.S.C. Section 47134. The preliminary application is accepted for review... operator, negotiate an agreement and submit a final application to the FAA for exemption under the pilot...

  13. 48 CFR 212.7002 - Pilot program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pilot program. 212.7002... OF DEFENSE ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Pilot Program for Transition to Follow-On Contracting After Use of Other Transaction Authority 212.7002 Pilot program. ...

  14. 75 FR 64692 - Green Technology Pilot Program

    Science.gov (United States)

    2010-10-20

    ... DEPARTMENT OF COMMERCE Patent and Trademark Office Green Technology Pilot Program ACTION: Proposed...- 0062 Green Technology Pilot Program comment'' in the subject line of the message. Fax: 571-273-0112... United States Patent and Trademark Office (USPTO) implemented a pilot program on December 8, 2009, that...

  15. 46 CFR 15.812 - Pilots.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Pilots. 15.812 Section 15.812 Shipping COAST GUARD....812 Pilots. (a) Except as specified in paragraph (f) of this section, the following vessels, not... direction and control of an individual qualified to serve as pilot under paragraph (b) or (c) of this...

  16. 7 CFR 1955.132 - Pilot projects.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Pilot projects. 1955.132 Section 1955.132 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.132 Pilot projects. FmHA or its successor agency under Public Law 103-354 may conduct pilot projects to test policies and...

  17. Ergonomic evaluation of pilot oxygen mask designs

    NARCIS (Netherlands)

    Lee, W.; Yang, Xiaopeng; Jung, Daehan; Park, Seikwon; Kim, Heeeun; You, Heecheon

    2018-01-01

    A revised pilot oxygen mask design was developed for better fit to the Korean Air Force pilots’ faces. The present study compared an existing pilot oxygen mask and a prototype of the revised mask design with 88 Korean Air Force pilots in terms of subjective discomfort, facial contact pressure,

  18. 77 FR 67433 - Community Advantage Pilot Program

    Science.gov (United States)

    2012-11-09

    ... comments. SUMMARY: The Community Advantage (``CA'') Pilot Program is a pilot program to increase SBA... small businesses and entrepreneurs in underserved markets, SBA is issuing this Notice to extend the term... Pilot Program was introduced to increase the number of SBA-guaranteed loans made to small businesses in...

  19. Cardiovascular Risk Factors in Airline Pilots.

    Science.gov (United States)

    Lord, Dana; Conlon, Helen Acree

    2018-02-01

    The health of an airline pilot is imperative to the safe travels of millions of people worldwide. Medical providers evaluate the cardiovascular risks for airline pilots and the medical requirements to obtain and maintain licensure as an airline pilot. It is the role of the occupational health nurse practitioner to evaluate and reduce the risk of cardiovascular disease in this population.

  20. D22 Analysis of Pilot

    NARCIS (Netherlands)

    Boyle, Elizabeth; MacGregor, Sharon; Van Rosmalen, Peter; Manea, Madalina; Penanen, Tiina

    2015-01-01

    The evaluation of the CHERMUG games was carried out in 3 phases which contributed in different ways to the game development and evaluation. Different cohorts of staff and students were involved in each phase and a detailed account of the list of pilot institutions is shown in Deliverable 21. Phase 1

  1. Research on Human-Error Factors of Civil Aircraft Pilots Based On Grey Relational Analysis

    Directory of Open Access Journals (Sweden)

    Guo Yundong

    2018-01-01

    Full Text Available In consideration of the situation that civil aviation accidents involve many human-error factors and show the features of typical grey systems, an index system of civil aviation accident human-error factors is built using human factor analysis and classification system model. With the data of accidents happened worldwide between 2008 and 2011, the correlation between human-error factors can be analyzed quantitatively using the method of grey relational analysis. Research results show that the order of main factors affecting pilot human-error factors is preconditions for unsafe acts, unsafe supervision, organization and unsafe acts. The factor related most closely with second-level indexes and pilot human-error factors is the physical/mental limitations of pilots, followed by supervisory violations. The relevancy between the first-level indexes and the corresponding second-level indexes and the relevancy between second-level indexes can also be analyzed quantitatively.

  2. Measuring moment-to-moment pilot workload using synchronous presentations of secondary tasks in a motion-base trainer

    Science.gov (United States)

    Bortolussi, Michael R.; Hart, Sandra G.; Shively, Robert J.

    1987-01-01

    A simulation was conducted to determine whether the sensitivity of secondary task measures of pilot workload could be improved by synchronizing their presentation to the occurrence of specific events or pilot actions. This synchronous method of presentation was compared to the more typical asynchronous method, where secondary task presentations are independent of pilot's flight-related activities. Twelve pilots flew low- and high-difficulty scenarios in a motion-base trainer with and without concurrent secondary tasks (e.g., choice reaction time and time production). The difficulty of each scenario was manipulated by the addition of 21 flight-related tasks superimposed on a standard approach and landing sequence. The insertion of the secondary tasks did not affect primary flight performance. However, secondary task performance did reflect workload differences between scenarios and among flight segments within scenarios, replicating the results of an earlier study in which the secondary tasks were presented asynchronously (Bortolussi et al., 1986).

  3. Sensory Adapted Dental Environments to Enhance Oral Care for Children with Autism Spectrum Disorders: A Randomized Controlled Pilot Study

    Science.gov (United States)

    Cermak, Sharon A.; Stein Duker, Leah I.; Williams, Marian E.; Dawson, Michael E.; Lane, Christianne J.; Polido, José C.

    2015-01-01

    This pilot and feasibility study examined the impact of a sensory adapted dental environment (SADE) to reduce distress, sensory discomfort, and perception of pain during oral prophylaxis for children with autism spectrum disorder (ASD). Participants were 44 children ages 6-12 (n = 22 typical, n = 22 ASD). In an experimental crossover design, each…

  4. Typicality Mediates Performance during Category Verification in Both Ad-Hoc and Well-Defined Categories

    Science.gov (United States)

    Sandberg, Chaleece; Sebastian, Rajani; Kiran, Swathi

    2012-01-01

    Background: The typicality effect is present in neurologically intact populations for natural, ad-hoc, and well-defined categories. Although sparse, there is evidence of typicality effects in persons with chronic stroke aphasia for natural and ad-hoc categories. However, it is unknown exactly what influences the typicality effect in this…

  5. For Your Local Eyes Only: Culture-Specific Face Typicality Influences Perceptions of Trustworthiness.

    Science.gov (United States)

    Sofer, Carmel; Dotsch, Ron; Oikawa, Masanori; Oikawa, Haruka; Wigboldus, Daniel H J; Todorov, Alexander

    2017-08-01

    Recent findings show that typical faces are judged as more trustworthy than atypical faces. However, it is not clear whether employment of typicality cues in trustworthiness judgment happens across cultures and if these cues are culture specific. In two studies, conducted in Japan and Israel, participants judged trustworthiness and attractiveness of faces. In Study 1, faces varied along a cross-cultural dimension ranging from a Japanese to an Israeli typical face. Own-culture typical faces were perceived as more trustworthy than other-culture typical faces, suggesting that people in both cultures employ typicality cues when judging trustworthiness, but that the cues, indicative of typicality, are culture dependent. Because perceivers may be less familiar with other-culture typicality cues, Study 2 tested the extent to which they rely on available facial information other than typicality, when judging other-culture faces. In Study 2, Japanese and Israeli faces varied from either Japanese or Israeli attractive to unattractive with the respective typical face at the midpoint. For own-culture faces, trustworthiness judgments peaked around own-culture typical face. However, when judging other-culture faces, both cultures also employed attractiveness cues, but this effect was more apparent for Japanese participants. Our findings highlight the importance of culture when considering the effect of typicality on trustworthiness judgments.

  6. 46 CFR 402.220 - Registration of pilots.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Registration of pilots. 402.220 Section 402.220 Shipping... ORDERS Registration of Pilots § 402.220 Registration of pilots. (a) Each applicant pilot must complete the number of round trips specified in this section prior to registration as a U.S. registered pilot...

  7. 46 CFR 401.220 - Registration of pilots.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Registration of pilots. 401.220 Section 401.220 Shipping... Registration of Pilots § 401.220 Registration of pilots. (a) The Director shall determine the number of pilots... waters of the Great Lakes and to provide for equitable participation of United States Registered Pilots...

  8. 14 CFR 29.1329 - Automatic pilot system.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Automatic pilot system. 29.1329 Section 29... pilot system. (a) Each automatic pilot system must be designed so that the automatic pilot can— (1) Be sufficiently overpowered by one pilot to allow control of the rotorcraft; and (2) Be readily and positively...

  9. 14 CFR 61.83 - Eligibility requirements for student pilots.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Eligibility requirements for student pilots... TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Student Pilots § 61.83 Eligibility requirements for student pilots. To be eligible for a student pilot...

  10. 14 CFR 27.1329 - Automatic pilot system.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Automatic pilot system. 27.1329 Section 27... pilot system. (a) Each automatic pilot system must be designed so that the automatic pilot can— (1) Be sufficiently overpowered by one pilot to allow control of the rotorcraft; and (2) Be readily and positively...

  11. Pilot chargeback system program plan

    International Nuclear Information System (INIS)

    Smith, P.

    1997-03-01

    This planning document outlines the steps necessary to develop, test, evaluate, and potentially implement a pilot chargeback system at the Idaho National Engineering and Environmental Laboratory for the treatment, storage, and disposal of current waste. This pilot program will demonstrate one system that can be used to charge onsite generators for the treatment and disposal of low-level radioactive waste. In FY 1997, mock billings will begin by July 15, 1997. Assuming approvals are received to do so, FY 1998 activities will include modifying the associated automated systems, testing and evaluating system performance, and estimating the amount generators will spend for waste storage, treatment, and disposal in FY 1999. If the program is fully implemented in FY 1999, generators will pay actual, automated bills for waste management services from funds transferred to their budgets from Environmental Management

  12. Bohmian mechanics without pilot waves

    International Nuclear Information System (INIS)

    Poirier, Bill

    2010-01-01

    In David Bohm's causal/trajectory interpretation of quantum mechanics, a physical system is regarded as consisting of both a particle and a wavefunction, where the latter 'pilots' the trajectory evolution of the former. In this paper, we show that it is possible to discard the pilot wave concept altogether, thus developing a complete mathematical formulation of time-dependent quantum mechanics directly in terms of real-valued trajectories alone. Moreover, by introducing a kinematic definition of the quantum potential, a generalized action extremization principle can be derived. The latter places very severe a priori restrictions on the set of allowable theoretical structures for a dynamical theory, though this set is shown to include both classical mechanics and quantum mechanics as members. Beneficial numerical ramifications of the above, 'trajectories only' approach are also discussed, in the context of simple benchmark applications.

  13. Bohmian mechanics without pilot waves

    Energy Technology Data Exchange (ETDEWEB)

    Poirier, Bill, E-mail: Bill.Poirier@ttu.edu [Department of Chemistry and Biochemistry, and Department of Physics, Texas Tech University, Box 41061, Lubbock, TX 79409-1061 (United States)

    2010-05-12

    In David Bohm's causal/trajectory interpretation of quantum mechanics, a physical system is regarded as consisting of both a particle and a wavefunction, where the latter 'pilots' the trajectory evolution of the former. In this paper, we show that it is possible to discard the pilot wave concept altogether, thus developing a complete mathematical formulation of time-dependent quantum mechanics directly in terms of real-valued trajectories alone. Moreover, by introducing a kinematic definition of the quantum potential, a generalized action extremization principle can be derived. The latter places very severe a priori restrictions on the set of allowable theoretical structures for a dynamical theory, though this set is shown to include both classical mechanics and quantum mechanics as members. Beneficial numerical ramifications of the above, 'trajectories only' approach are also discussed, in the context of simple benchmark applications.

  14. PSF support pilot program

    Science.gov (United States)

    Anderson, Jay

    2013-10-01

    The goal of this program is to observe the center of Omega Cen {which has a nice flat distribution of reasonably-spaced-out stars} in order to construct a PSF model for ACS's three workhorse filters: F435W, F606W, and F814W. These also happen to be the three ACS filters that will be used in the Frontier-Field program. PI-Anderson will use the data to consturct an 9x10 array of fiducial PSFs that describe the static variation of the PSF across the frame for each filter. He will also provide some simple routines that the public can use to insert PSFs into images.The observations will dither the center of the cluster around in a circle with a radius of about 30" such that any single star never falls in the ACS gap more than once. This has the additional benefit that we can use this large dither to validate or improve the distortion solution at the same time we are solving for the PSF. We will get four exposures through each of the ACS filters. The exposure times for the three ACS filters {F435W, F606W, and F814W} were chosen to maximize the number of bright unsaturated stars while simultaneously minimizing the number of saturated stars present. To do this, we made sure that the SGB {which is where the LF rises precipitously} is just below the saturation level. We used archival images from GO-9444 and GO-10775 to ensure that 339s for F435W, 80s in F606W, and 90s in F814W is perfect for this.In addition to the ACS exposures, we also take parallels with WFC3/IR. These exposures will sample a field that is 6' off center. The core radius is 2.5', so this outer field should have a density that is 5x lower than at the center, meaning the typical star is maybe 2.5x farther away. This should compensate for the larger WFC3/IR pixels and will allow us to construct PSFs that are appropriate. We take a total of 32 WFC3/IR exposures, each with an exposure time of 103s, and divide these 32 exposures among the four FF WFC3/IR exposures: F105W, F125W, F140W, and F160W. We will use

  15. Results from the CERN pilot CLOUD experiment

    International Nuclear Information System (INIS)

    Duplissy, J.; David, A.; Hahn, F.; Kirkby, J.; Onnela, A.; Veenhof, R.; Wilhelmsson, M.; Enghoff, M.B.; Avngaard, M.; Bondo, T.; Marsh, N.D.; Pedersen, O.P.; Polny, J.; Svensmark, H.; Svensmark, J.; Aplin, K.L.; Bingham, R.; Kellett, B.; Lockwood, M.; Arnold, F.; Aufmhoff, H.; Reichl, U.; Verheggen, B.; Baltensperger, U.; Wehrle, G.; Weingartner, E.; Carslaw, K.; Curtius, J.; Fastrup, B.; Pedersen, E.; Gagne, S.; Kulmala, M.; Laakso, L.; Nieminen, T.; Sipila, M.; Harrison, R.G.; Laaksonen, A.; Lillestol, E.; Makela, J.; Makhmutov, V.; Stozhkov, Y.; Seinfeld, J.H.; Stratmann, F.; Wex, H.; Viisanen, Y.; Wagner, P.E.; Winkler, P.M.

    2010-01-01

    During a 4-week run in October-November 2006, a pilot experiment was performed at the CERN Proton Synchrotron in preparation for the Cosmics Leaving Outdoor Droplets (CLOUD) experiment, whose aim is to study the possible influence of cosmic rays on clouds. The purpose of the pilot experiment was firstly to carry out exploratory measurements of the effect of ionising particle radiation on aerosol formation from trace H2SO4 vapour and secondly to provide technical input for the CLOUD design. A total of 44 nucleation bursts were produced and recorded, with formation rates of particles above the 3 nm detection threshold of between 0.1 and 100 cm -3 s -1 , and growth rates between 2 and 37 nm h -1 . The corresponding H2SO4 concentrations were typically around 106 cm -3 or less. The experimentally-measured formation rates and H2SO4 concentrations are comparable to those found in the atmosphere, supporting the idea that sulphuric acid is involved in the nucleation of atmospheric aerosols. However, sulphuric acid alone is not able to explain the observed rapid growth rates, which suggests the presence of additional trace vapours in the aerosol chamber, whose identity is unknown. By analyzing the charged fraction, a few of the aerosol bursts appear to have a contribution from ion-induced nucleation and ion-ion recombination to form neutral clusters. Some indications were also found for the accelerator beam timing and intensity to influence the aerosol particle formation rate at the highest experimental SO2 concentrations of 6 ppb, although none was found at lower concentrations. Overall, the exploratory measurements provide suggestive evidence for ion-induced nucleation or ion-ion recombination as sources of aerosol particles. However in order to quantify the conditions under which ion processes become significant, improvements are needed in controlling the experimental variables and in the reproducibility of the experiments. Finally, concerning technical aspects, the most

  16. Strengthening Incarcerated Families: Evaluating a Pilot Program for Children of Incarcerated Parents and Their Caregivers

    OpenAIRE

    Miller, Alison L.; Perryman, Jamie; Markovitz, Lara; Franzen, Susan; Cochran, Shirley; Brown, Shavonnea

    2013-01-01

    Parental incarceration can be devastating for families. Children may experience difficulties, and the stress on caregivers who take on unexpected childrearing is high. We implemented and evaluated a family-level intervention with caregivers and children experiencing parental (typically maternal) incarceration, in a community setting. We partnered with a community-based organization serving families with an incarcerated parent to conduct a pilot trial of the Strengthening Families Program (SFP...

  17. Carbon dioxide cleaning pilot project

    International Nuclear Information System (INIS)

    Knight, L.; Blackman, T.E.

    1994-01-01

    In 1989, radioactive-contaminated metal at the Rocky Flats Plant (RFP) was cleaned using a solvent paint stripper (Methylene chloride). One-third of the radioactive material was able to be recycled; two-thirds went to the scrap pile as low-level mixed waste. In addition, waste solvent solutions also required disposal. Not only was this an inefficient process, it was later prohibited by the Resource Conservation and Recovery Act (RCRA), 40 CFR 268. A better way of doing business was needed. In the search for a solution to this situation, it was decided to study the advantages of using a new technology - pelletized carbon dioxide cleaning. A proof of principle demonstration occurred in December 1990 to test whether such a system could clean radioactive-contaminated metal. The proof of principle demonstration was expanded in June 1992 with a pilot project. The purpose of the pilot project was three fold: (1) to clean metal so that it can satisfy free release criteria for residual radioactive contamination at the Rocky Flats Plant (RFP); (2) to compare two different carbon dioxide cleaning systems; and (3) to determine the cost-effectiveness of decontamination process in a production situation and compare the cost of shipping the metal off site for waste disposal. The pilot project was completed in August 1993. The results of the pilot project were: (1) 90% of those items which were decontaminated, successfully met the free release criteria , (2) the Alpheus Model 250 was selected to be used on plantsite and (3) the break even cost of decontaminating the metal vs shipping the contaminated material offsite for disposal was a cleaning rate of 90 pounds per hour, which was easily achieved

  18. The National Conversion Pilot Project

    International Nuclear Information System (INIS)

    Roberts, A.V.

    1995-01-01

    The National Conversion Pilot Project (NCPP) is a recycling project under way at the U.S. Department of Energy (DOE) Rocky Flats Environmental Technology Site (RFETS) in Colorado. The recycling aim of the project is threefold: to reuse existing nuclear weapon component production facilities for the production of commercially marketable products, to reuse existing material (uranium, beryllium, and radioactively contaminated scrap metals) for the production of these products, and to reemploy former Rocky Flats workers in this process

  19. Exploration of Rice Husk Compost as an Alternate Organic Manure to Enhance the Productivity of Blackgram in Typic Haplustalf and Typic Rhodustalf

    Directory of Open Access Journals (Sweden)

    Subramanium Thiyageshwari

    2018-02-01

    Full Text Available The present study was aimed at using cellulolytic bacterium Enhydrobacter and fungi Aspergillus sp. for preparing compost from rice husk (RH. Further, the prepared compost was tested for their effect on blackgram growth promotion along with different levels of recommended dose of fertilizer (RDF in black soil (typic Haplustalf and red soil (typic Rhodustalf soil. The results revealed that, inoculation with lignocellulolytic fungus (LCF Aspergillus sp. @ 2% was considered as the most efficient method of composting within a short period. Characterization of composted rice husk (CRH was examined through scanning electron microscope (SEM for identifying significant structural changes. At the end of composting, N, P and K content increased with decrease in CO2 evolution, C:N and C:P ratios. In comparison to inorganic fertilization, an increase in grain yield of 16% in typic Haplustalf and 17% in typic Rhodustalf soil over 100% RDF was obtained from the integrated application of CRH@ 5 t ha−1 with 50% RDF and biofertilizers. The crude protein content was maximum with the combined application of CRH, 50% RDF and biofertilizers of 20% and 21% in typic Haplustalf and typic Rhodustalf soils, respectively. Nutrient rich CRH has proved its efficiency on crop growth and soil fertility.

  20. Electrocoagulation project: Pilot study testwork

    Energy Technology Data Exchange (ETDEWEB)

    Donini, J.C.; Garand, D.K.; Hassan, T.A.; Kar, K.L.; Thind, S.S.

    1991-09-01

    When a suspension or emulsion flows between two sacrificial metal electrodes excited by ac, the dispersed phase is consolidated and then settles. Laboratory-scale investigation of this mechanism, called electrocoagulation, and of its areas of application to water treatment were previously completed and a subsequent project was initiated to design and construct pilot-scale equipment consisting of an electrocoagulation cell, power supply, and computerized control system. The constructed pilot plant was used to test the effectiveness of electrocoagulation to clarify coal processing plant effluent. Results obtained with clay suspensions showed that flow conditions in the cell have a major effect on electric power consumption, and a reduction by a factor of three on this crucial cost parameter appeared possible compared to a previously tested batch-scale electrocoagulation system. Results obtained using the coal plant thickener feed closely duplicated those obtained with the clay mixtures. Aluminum electrode consumption, however, remained unchanged compared to the bench-scale tests. Supernatant clarity far exceeded requirements, while settling rate was too low. The settling could be speeded up by appropriate use of chemicals, but such addition affects the coagulation mechanism and reduces supernatant clarity. A tradeoff between settling rate and clarity was thus established. The total cost of treatment was deemed to be in excess of coal company requirements, but the pilot tests revealed much about the electrocoagulation system under continuous flow conditions. The technology is seen as having application in other areas such as municipal and industrial waste treatment. 22 refs., 6 figs., 2 tabs.

  1. Pilot Implementation of Health Information Systems

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2009-01-01

    Pilot implementation is a powerful and widely used approach in identifying design flaws and implementation issues before the full-scale deployment of new health information systems. However, pilot implementations often fail in the sense that they say little about the usability and usefulness...... of the proposed system designs. This calls for studies that seek to uncover and analyze the reasons for failure, so that guidelines for conducting such pilots can be developed. In this paper, we present a qualitative field study of an ambitious, but unsuccessful pilot implementation of a Danish healthcare...... information system. Based on the findings from this study, we identify three main challenges: (1) defining an appropriate scope for pilot implementation, (2) managing the implementation process, and (3) ensuring commitment to the pilot. Finally, recommendations for future research and implications...

  2. Retaining U.S. Air Force Pilots When the Civilian Demand for Pilots Is Growing

    Science.gov (United States)

    2016-01-01

    compensation, so a 1-percent increase in basic pay is like a 0.6-percent increase in total pay, other things being equal . If so, the retention change...at other major airlines.3 The collective bargaining agreement called for American/US Airways pilots to reach pay parity with Delta and United pilots...non-veterans in non- pilot occupations after controlling for age, education, and gender . But the results show that pilots who are veterans earn 10 to

  3. Reducing Air Force Fighter Pilot Shortages

    Science.gov (United States)

    2015-12-31

    units). Pilot positions can be divided into two categories: absorbing and nonabsorbing. Absorbing positions are in operational units to which...Continued Attention to Aircrew Management Dynamics The primary source of stress in fighter- pilot management has been reductions in aircraft inventories...Fighter Pilot Shortages C O R P O R A T I O N Limited Print and Electronic Distribution Rights This document and trademark(s) contained herein are

  4. 14 CFR 61.113 - Private pilot privileges and limitations: Pilot in command.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Private pilot privileges and limitations: Pilot in command. 61.113 Section 61.113 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND...

  5. 76 FR 22412 - Fellowship Placement Pilot Program Requests for Expressions of Interests To Administer Pilot...

    Science.gov (United States)

    2011-04-21

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5514-C-02] Fellowship Placement Pilot Program Requests for Expressions of Interests To Administer Pilot Contact Information Correction AGENCY... published a notice announcing HUD's proposal to conduct a Fellowship Placement Pilot (fellowship program...

  6. 14 CFR 91.1089 - Qualifications: Check pilots (aircraft) and check pilots (simulator).

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Qualifications: Check pilots (aircraft) and check pilots (simulator). 91.1089 Section 91.1089 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... RULES Fractional Ownership Operations Program Management § 91.1089 Qualifications: Check pilots...

  7. 90% Compliance Pilot Studies Final Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    In early 2010, the U.S. Department of Energy (DOE) announced an opportunity for states to participate in energy code compliance evaluation pilot studies. DOE worked with five Regional Energy Efficiency Organizations (REEOs, formerly referred to as Energy Efficiency Partnerships, or EEPs) to fund pilot studies covering nine states. This report details conclusions stated in individual state reports, as well as conclusions drawn by DOE based on their oversight of the pilot studies, and based on discussions held with the REEOs and representatives from the pilot study states and their contractors.

  8. Pilot 2006 Environmental Performance Index (EPI)

    Data.gov (United States)

    National Aeronautics and Space Administration — The Pilot 2006 Environmental Performance Index (EPI) centers on two broad environmental protection objectives: (1) reducing environmental stresses on human health,...

  9. Shared temporoparietal dysfunction in dyslexia and typical readers with discrepantly high IQ.

    Science.gov (United States)

    Hancock, Roeland; Gabrieli, John D E; Hoeft, Fumiko

    2016-12-01

    It is currently believed that reading disability (RD) should be defined by reading level without regard to broader aptitude (IQ). There is debate, however, about how to classify individuals who read in the typical range but less well than would be expected by their higher IQ. We used functional magnetic resonance imaging (fMRI) in 49 children to examine whether those with typical, but discrepantly low reading ability relative to IQ, show dyslexia-like activation patterns during reading. Children who were typical readers with high-IQ discrepancy showed reduced activation in left temporoparietal neocortex relative to two control groups of typical readers without IQ discrepancy. This pattern was consistent and spatially overlapping with results in children with RD compared to typically reading children. The results suggest a shared neurological atypicality in regions associated with phonological processing between children with dyslexia and children with typical reading ability that is substantially below their IQ.

  10. Predictors and consequences of gender typicality: the mediating role of communality.

    Science.gov (United States)

    DiDonato, Matthew D; Berenbaum, Sheri A

    2013-04-01

    Considerable work has shown the benefits for psychological health of being gender typed (i.e., perceiving oneself in ways that are consistent with one's sex). Nevertheless, little is known about the reasons for the link. In two studies of young adults (total N = 673), we studied (1) the ways in which gender typing is predicted from gender-related interests and personal qualities, and (2) links between gender typing and adjustment (self-esteem and negative emotionality). In the first study, gender typicality was positively predicted by a variety of gender-related characteristics and by communal traits, a female-typed characteristic; gender typicality was also positively associated with adjustment. To clarify the role of communality in predicting gender typicality and its link with adjustment, we conducted a follow-up study examining both gender typicality and "university typicality." Gender typicality was again predicted by gender-related characteristics and communality, and associated with adjustment. Further, university typicality was also predicted by communality and associated with adjustment. Mediation analyses showed that feelings of communality were partly responsible for the links between gender/university typicality and adjustment. Thus, the psychological benefits suggested to accrue from gender typicality may not be specific to gender, but rather may reflect the benefits of normativity in general. These findings were discussed in relation to the broader literature on the relation between identity and adjustment.

  11. Pilot solid-waste incinerator

    International Nuclear Information System (INIS)

    Farber, M.G.; Hootman, H.E.; Trapp, D.J.

    1982-01-01

    An experimental program to develop and confirm technology for incinerating solid radioactive waste is in progress at the Savannah River Laboratory (SRL) in support of the short-term and long-term waste management objectives of the Savannah River Plant (SRP). This report reviews the experience of a pilot incinerator with a capacity of 1.0 lb/hr. The facility was tested with nonradioactive materials similar to the radioactive waste generated at the Savannah River site. The experimental program included determining operating parameters, testing wet and dry off-gas treatment systems, and evaluating materials of construction

  12. Conflict Resolution Automation and Pilot Situation Awareness

    Science.gov (United States)

    Dao, Arik-Quang V.; Brandt, Summer L.; Bacon, Paige; Kraut, Josh; Nguyen, Jimmy; Minakata, Katsumi; Raza, Hamzah; Rozovski, David; Johnson, Walter W.

    2010-01-01

    This study compared pilot situation awareness across three traffic management concepts. The Concepts varied in terms of the allocation of traffic avoidance responsibility between the pilot on the flight deck, the air traffic controllers, and a conflict resolution automation system. In Concept 1, the flight deck was equipped with conflict resolution tools that enable them to fully handle the responsibility of weather avoidance and maintaining separation between ownship and surrounding traffic. In Concept 2, pilots were not responsible for traffic separation, but were provided tools for weather and traffic avoidance. In Concept 3, flight deck tools allowed pilots to deviate for weather, but conflict detection tools were disabled. In this concept pilots were dependent on ground based automation for conflict detection and resolution. Situation awareness of the pilots was measured using online probes. Results showed that individual situation awareness was highest in Concept 1, where the pilots were most engaged, and lowest in Concept 3, where automation was heavily used. These findings suggest that for conflict resolution tasks, situation awareness is improved when pilots remain in the decision-making loop.

  13. Pilot Task Demand Load During RNAV Approaches

    NARCIS (Netherlands)

    Heiligers, M.M.

    2011-01-01

    The question that started this research was: “Why is approach A more difficult to fly for a pilot than approach B?”. To find an answer to this question, pilots flew a large variety of Area Navigation (RNAV) approaches during several flight simulator and real flight experiments. The results of these

  14. Analysis of empty ATLAS pilot jobs

    CERN Document Server

    Love, Peter; The ATLAS collaboration

    2016-01-01

    The pilot model used by the ATLAS production system has been in use for many years. The model has proven to be a success with many advantages over push models. However one of the negative side-effects of using a pilot model is the presence of 'empty pilots' running on sites which consume a small amount of walltime and not running a useful payload job. The impact on a site can be significant with previous studies showing a total 0.5% walltime usage with no benefit to either the site or to ATLAS. Another impact is the number of empty pilots being processed by a site's Compute Element and batch system which can be 5% of the total number of pilots being handled. In this paper we review the latest statistics using both ATLAS and site data and highlight edge cases where the number of empty pilots dominate. We also study the effect of tuning the pilot factories to reduce the number of empty pilots.

  15. Age Learning Factors Affecting Pilot Education.

    Science.gov (United States)

    Torbert, Brison

    This document, intended for pilot education and flight safety specialists, consists chiefly of a review of the literature on physiological factors that affect pilot education and an examination of environmental factors that should be scrutinized in order to improve the effectiveness of aviation learning facilities. The physiological factors…

  16. Modelling piloted ignition of wood and plastics

    NARCIS (Netherlands)

    Blijderveen, M.; Bramer, Eduard A.; Brem, Gerrit

    2012-01-01

    To gain insight in the startup of an incinerator, this article deals with piloted ignition. A newly developed model is described to predict the piloted ignition times of wood, PMMA and PVC. The model is based on the lower flammability limit and the adiabatic flame temperature at this limit. The

  17. The Pilot Staffing Conundrum: A Delphi Study

    Science.gov (United States)

    2009-06-01

    Project, AFIT/ GMO /LAL/98J-2. School of Logistics and Acquisition Management, Air Force Institute of Technology (AU), Wright Patterson AFB, OH, June...Kafer, John H. Relationship of Airline Pilot Demand and Air Force Pilot Retention. Graduate Research Project, AFIT/ GMO /LAL/98J-11. School of Logistics

  18. Personnel thermoluminescent dosimetry of plane pilots

    International Nuclear Information System (INIS)

    Azorin V, J.C.; Rivera M, T.; Azorin N, J.

    1999-01-01

    In this work are presented the results of the research realized in the pilots of commercial planes of the different flight equipment existing. The results obtained show that the pilots receive during their work, doses of ionizing radiation greater than the limit recommended by the International Commission of Radiological Protection. (Author)

  19. 77 FR 6619 - Community Advantage Pilot Program

    Science.gov (United States)

    2012-02-08

    ... access to capital for small businesses and entrepreneurs in underserved markets, SBA is issuing this... (``CA Pilot Program'') (76 FR 9626). The CA Pilot Program was introduced to increase SBA-guaranteed... small businesses and entrepreneurs in underserved markets, SBA is issuing this Notice to revise several...

  20. PILOT: A Programming Language for Beginners.

    Science.gov (United States)

    Schnorr, Janice M.

    The presentation describes PILOT (Programmed Inquiry, Learning or Teaching), a special programing language easy for beginners to learn and available for several brands of microcomputers. PILOT is explained to contain substantially fewer commands than most other languages and to be written in an easy to understand manner. Edit commands and their…

  1. Pilot beverage cartons : extended technical report

    NARCIS (Netherlands)

    Thoden van Velzen, E.U.; Brouwer, M.T.; Keijsers, E.R.P.; Pretz, Th.; Feil, A.; Jansen, M.

    2014-01-01

    This report gives a technological description of the four common collection and recycling schemes that have been tested in the Netherlands as part of the pilot beverage cartons in 2013. During this pilot the collection and recycling of beverage cartons was tested in 37 different municipalities, with

  2. Pilot scale simulation of cokemaking in integrated steelworks

    Energy Technology Data Exchange (ETDEWEB)

    Mahoney, M.; Andriopoulos, N.; Keating, J.; Loo, C.E.; McGuire, S. [Newcastle Technology Centre, Wallsend (Australia)

    2005-12-01

    Pilot scale coke ovens are widely used to produce coke samples for characterisation and also to assess the coking behaviour of coal blends. The Newcastle Technology Centre of BHP Billiton has built a sophisticated 400 kg oven, which can produce cokes under a range of carefully controlled bulk densities and heating rates. A freely movable heating wall allows the thrust generated at this wall at the different stages of coking oven to be determined. This paper describes comparative work carried out to determine a laboratory stabilisation technique for laboratory cokes. The strength of stabilised cokes are characterised using a number of tumble tests, and correlations between different drum sizes are also given since a major constraint in laboratory testing is the limitation in the mass of sample available. Typical oven wall pressure results, and results obtained from embedded temperature and pressure probes in the charge during coking, are also presented.

  3. Pilot Implementations as an Approach to Infrastructure

    DEFF Research Database (Denmark)

    Manikas, Maria Ie; Torkilsheyggi, Arnvør Martinsdóttir á

    In this paper we introduce pilot implementation, a supplement to information systems development, as an approach to study and design work infrastructures. We report from two pilot implementations in the Danish healthcare, which showed signs of grappling with aligning the past, present...... and the future while using a pilot system in real use situations and with real users. Based on our initial findings we believe that pilot implementations can address some of the challenges of studying infrastructures, because they make the infrastructure visible and because they can integrate the long......-term with the short-term aspects. The paper is based on work-in-progress and the purpose is not as much to make conclusions as to spark discussion about whether pilot implementations could offer a way to study and design work infrastructures during information system development....

  4. Analysis of empty ATLAS pilot jobs

    Science.gov (United States)

    Love, P. A.; Alef, M.; Dal Pra, S.; Di Girolamo, A.; Forti, A.; Templon, J.; Vamvakopoulos, E.; ATLAS Collaboration

    2017-10-01

    In this analysis we quantify the wallclock time used by short empty pilot jobs on a number of WLCG compute resources. Pilot factory logs and site batch logs are used to provide independent accounts of the usage. Results show a wide variation of wallclock time used by short jobs depending on the site and queue, and changing with time. For a reference dataset of all jobs in August 2016, the fraction of wallclock time used by empty jobs per studied site ranged from 0.1% to 0.8%. Aside from the wall time used by empty pilots, we also looked at how many pilots were empty as a fraction of all pilots sent. Binning the August dataset into days, empty fractions between 2% and 90% were observed. The higher fractions correlate well with periods of few actual payloads being sent to the site.

  5. 16 CFR Figure 5 to Part 1610 - An Example of a Typical Gas Shield

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false An Example of a Typical Gas Shield 5 Figure 5 to Part 1610 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... Example of a Typical Gas Shield ER25MR08.004 ...

  6. 16 CFR Figure 4 to Part 1610 - An Example of a Typical Indicator Finger

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false An Example of a Typical Indicator Finger 4 Figure 4 to Part 1610 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... Example of a Typical Indicator Finger ER25MR08.003 ...

  7. 29 CFR 780.210 - The typical hatchery operations constitute “agriculture.”

    Science.gov (United States)

    2010-07-01

    ... EXEMPTIONS APPLICABLE TO AGRICULTURE, PROCESSING OF AGRICULTURAL COMMODITIES, AND RELATED SUBJECTS UNDER THE FAIR LABOR STANDARDS ACT Agriculture as It Relates to Specific Situations Hatchery Operations § 780.210 The typical hatchery operations constitute “agriculture.” As stated in § 780.127, the typical hatchery...

  8. Gestures in Prelinguistic Turkish Children with Autism, Down Syndrome, and Typically Developing Children

    Science.gov (United States)

    Toret, Gokhan; Acarlar, Funda

    2011-01-01

    The purpose of this study was to examine gesture use in Turkish children with autism, Down syndrome, and typically developing children. Participants included 30 children in three groups: Ten children with Down syndrome, ten children with autism between 24-60 months of age, and ten typically developing children between 12-18 months of age.…

  9. Hemolytic porcine intestinal Escherichia coli without virulence-associated genes typical of intestinal pathogenic E. coli.

    Science.gov (United States)

    Schierack, Peter; Weinreich, Joerg; Ewers, Christa; Tachu, Babila; Nicholson, Bryon; Barth, Stefanie

    2011-12-01

    Testing 1,666 fecal or intestinal samples from healthy and diarrheic pigs, we obtained hemolytic Escherichia coli isolates from 593 samples. Focusing on hemolytic E. coli isolates without virulence-associated genes (VAGs) typical for enteropathogens, we found that such isolates carried a broad variety of VAGs typical for extraintestinal pathogenic E. coli.

  10. Lipreading Ability and Its Cognitive Correlates in Typically Developing Children and Children with Specific Language Impairment

    Science.gov (United States)

    Heikkilä, Jenni; Lonka, Eila; Ahola, Sanna; Meronen, Auli; Tiippana, Kaisa

    2017-01-01

    Purpose: Lipreading and its cognitive correlates were studied in school-age children with typical language development and delayed language development due to specific language impairment (SLI). Method: Forty-two children with typical language development and 20 children with SLI were tested by using a word-level lipreading test and an extensive…

  11. For your local eyes only: Culture-specific face typicality influences perceptions of trustworthiness

    NARCIS (Netherlands)

    Sofer, C.; Dotsch, R.; Oikawa, M.; Oikawa, H.; Wigboldus, D.H.J.; Todorov, A.T.

    2017-01-01

    Recent findings show that typical faces are judged as more trustworthy than atypical faces. However, it is not clear whether employment of typicality cues in trustworthiness judgment happens across cultures and if these cues are culture specific. In two studies, conducted in Japan and Israel,

  12. Health-Related Quality of Life in Children Attending Special and Typical Education Greek Schools

    Science.gov (United States)

    Papadopoulou, D.; Malliou, P.; Kofotolis, N.; Vlachopoulos, S. P.; Kellis, E.

    2017-01-01

    The purpose of this study was to examine parental perceptions about Health Related Quality of Life (HRQoL) of typical education and special education students in Greece. The Pediatric Quality of Life Inventory (PedsQL) was administered to the parents of 251 children from typical schools, 46 students attending integration classes (IC) within a…

  13. Using Typical Infant Development to Inform Music Therapy with Children with Disabilities

    Science.gov (United States)

    Wheeler, Barbara L.; Stultz, Sylvia

    2008-01-01

    This article illustrates some ways in which observations of typically-developing infants can inform music therapy and other work with children with disabilities. The research project that is described examines typical infant development with special attention to musical relatedness and communication. Videotapes of sessions centering on musical…

  14. Motor Skill Performance by Low SES Preschool and Typically Developing Children on the PDMS-2

    Science.gov (United States)

    Liu, Ting; Hoffmann, Chelsea; Hamilton, Michelle

    2017-01-01

    The purpose of this study was to compare the motor skill performance of preschool children from low socioeconomic (SES) backgrounds to their age matched typically developing peers using the Peabody Developmental Motor Scales-2 (PDMS-2). Sixty-eight children (34 low SES and 34 typically developing; ages 3-5) performed the PDMS-2. Standard scores…

  15. Development of Gender Discrimination: Effect of Sex-Typical and Sex-Atypical Toys.

    Science.gov (United States)

    Etaugh, Claire; Duits, Terri L.

    Toddlers (41 girls and 35 boys) between 18 and 37 months of age were given four gender discrimination tasks each consisting of 6 pairs of color drawings. Three of the tasks employed color drawings of preschool girls and boys holding either a sex-typical toy, a sex-atypical toy, or no toy. The fourth employed pictures of sex-typical masculine and…

  16. On the role of object knowledge in reference production : Effects of color typicality on content determination

    NARCIS (Netherlands)

    Westerbeek, H.G.W.; Koolen, R.M.F.; Maes, A.A.; Bello, Paul; Guarini, Marcello; McShane, Marjorie; Scassellati, Brian

    2014-01-01

    In two language production experiments, we investigated whether stored knowledge of the typical color of objects affects spoken reference. In experiment 1, human speakers referred to objects with colors ranging from very typical (e.g., red tomato) to very atypical (e.g., blue pepper). The

  17. Mother-Child Play: Children with Down Syndrome and Typical Development

    Science.gov (United States)

    Venuti, P.; de Falco, S.; Esposito, G.; Bornstein, Marc H.

    2009-01-01

    Child solitary and collaborative mother-child play with 21 children with Down syndrome and 33 mental-age-matched typically developing children were compared. In solitary play, children with Down syndrome showed less exploratory but similar symbolic play compared to typically developing children. From solitary to collaborative play, children with…

  18. Examining the Language Phenotype in Children with Typical Development, Specific Language Impairment, and Fragile X Syndrome

    Science.gov (United States)

    Haebig, Eileen; Sterling, Audra; Hoover, Jill

    2016-01-01

    Purpose: One aspect of morphosyntax, finiteness marking, was compared in children with fragile X syndrome (FXS), specific language impairment (SLI), and typical development matched on mean length of utterance (MLU). Method: Nineteen children with typical development (mean age = 3.3 years), 20 children with SLI (mean age = 4.9 years), and 17 boys…

  19. Effects of Biofeedback on Control and Generalization of Nasalization in Typical Speakers

    Science.gov (United States)

    Murray, Elizabeth S. Heller; Mendoza, Joseph O.; Gill, Simone V.; Perkell, Joseph S.; Stepp, Cara E.

    2016-01-01

    Purpose: The purpose of this study was to determine the effects of biofeedback on control of nasalization in individuals with typical speech. Method: Forty-eight individuals with typical speech attempted to increase and decrease vowel nasalization. During training, stimuli consisted of consonant-vowel-consonant (CVC) tokens with the center vowels…

  20. Typical and Atypical Development of Basic Numerical Skills in Elementary School

    Science.gov (United States)

    Landerl, Karin; Kolle, Christina

    2009-01-01

    Deficits in basic numerical processing have been identified as a central and potentially causal problem in developmental dyscalculia; however, so far not much is known about the typical and atypical development of such skills. This study assessed basic number skills cross-sectionally in 262 typically developing and 51 dyscalculic children in…

  1. Establishing Contextual Control over Symmetry and Asymmetry Performances in Typically Developing Children and Children with Autism

    Science.gov (United States)

    O'Connor, Jennifer; Barnes-Holmes, Yvonne; Barnes-Holmes, Dermot

    2011-01-01

    Experiments 1, 2, and 3 investigated generalized contextually controlled symmetry and asymmetry in typically developing children and children with autism. In Experiment 1, eight typically developing children demonstrated the target performances without intervention. In Experiment 2, multiple-exemplar training and the use of familiar stimuli…

  2. Impact of Typical Aging and Parkinson's Disease on the Relationship among Breath Pausing, Syntax, and Punctuation

    Science.gov (United States)

    Huber, Jessica E.; Darling, Meghan; Francis, Elaine J.; Zhang, Dabao

    2012-01-01

    Purpose: The present study examines the impact of typical aging and Parkinson's disease (PD) on the relationship among breath pausing, syntax, and punctuation. Method: Thirty young adults, 25 typically aging older adults, and 15 individuals with PD participated. Fifteen participants were age- and sex-matched to the individuals with PD.…

  3. Typicality aids search for an unspecified target, but only in identification and not in attentional guidance.

    Science.gov (United States)

    Castelhano, Monica S; Pollatsek, Alexander; Cave, Kyle R

    2008-08-01

    Participants searched for a picture of an object, and the object was either a typical or an atypical category member. The object was cued by either the picture or its basic-level category name. Of greatest interest was whether it would be easier to search for typical objects than to search for atypical objects. The answer was"yes," but only in a qualified sense: There was a large typicality effect on response time only for name cues, and almost none of the effect was found in the time to locate (i.e., first fixate) the target. Instead, typicality influenced verification time-the time to respond to the target once it was fixated. Typicality is thus apparently irrelevant when the target is well specified by a picture cue; even when the target is underspecified (as with a name cue), it does not aid attentional guidance, but only facilitates categorization.

  4. EnerGEO biomass pilot

    International Nuclear Information System (INIS)

    Tum, M.; Guenther, K.P.; McCallum, I.; Balkovic, J.; Khabarov, N.; Kindermann, G.; Leduc, S.; Biberacher, M.

    2013-01-01

    In the framework of the EU FP7 project EnerGEO (Earth Observations for Monitoring and Assessment of the Environmental Impact of Energy Use) sustainable energy potentials for forest and agricultural areas were estimated by applying three different model approaches. Firstly, the Biosphere Energy Transfer Hydrology (BETHY/DLR) model was applied to assess agricultural and forest biomass increases on a regional scale with the extension to grassland. Secondly, the EPIC (Environmental Policy Integrated Climate) - a cropping systems simulation model - was used to estimate grain yields on a global scale and thirdly the Global Forest Model (G4M) was used to estimate global woody biomass harvests and stock. The general objective of the biomass pilot is to implement the observational capacity for using biomass as an important current and future energy resource. The scope of this work was to generate biomass energy potentials for locations on the globe and to validate these data. Therefore, the biomass pilot was focused to use historical and actual remote sensing data as input data for the models. For validation purposes, forest biomass maps for 1987 and 2002 for Germany (Bundeswaldinventur (BWI-2)) and 2001 and 2008 for Austria (Austrian Forest Inventory (AFI)) were prepared as reference. (orig.)

  5. Piloting improved cookstoves in India.

    Science.gov (United States)

    Lewis, Jessica J; Bhojvaid, Vasundhara; Brooks, Nina; Das, Ipsita; Jeuland, Marc A; Patange, Omkar; Pattanayak, Subhrendu K

    2015-01-01

    Despite the potential of improved cookstoves to reduce the adverse environmental and health impacts of solid fuel use, their adoption and use remains low. Social marketing-with its focus on the marketing mix of promotion, product, price, and place-offers a useful way to understand household behaviors and design campaigns to change biomass fuel use. We report on a series of pilots across 3 Indian states that use different combinations of the marketing mix. We find sales varying from 0% to 60%. Behavior change promotion that combined door-to-door personalized demonstrations with information pamphlets was effective. When given a choice amongst products, households strongly preferred an electric stove over improved biomass-burning options. Among different stove attributes, reduced cooking time was considered most valuable by those adopting a new stove. Households clearly identified price as a significant barrier to adoption, while provision of discounts (e.g., rebates given if households used the stove) or payments in installments were related to higher purchase. Place-based factors such as remoteness and nongovernmental organization operations significantly affected the ability to supply and convince households to buy and use improved cookstoves. Collectively, these pilots point to the importance of continued and extensive testing of messages, pricing models, and different stove types before scale-up. Thus, we caution that a one-size-fits-all approach will not boost improved cookstove adoption.

  6. EnerGEO biomass pilot

    Energy Technology Data Exchange (ETDEWEB)

    Tum, M.; Guenther, K.P. [German Aerospace Center (DLR), Wessling (Germany). German Remote Sensing Data Center (DFD); McCallum, I.; Balkovic, J.; Khabarov, N.; Kindermann, G.; Leduc, S. [International Institute for Applied Systems Analysis (IIASA), Laxenburg (Austria); Biberacher, M. [Research Studios Austria AG (RSA), Salzburg (Austria)

    2013-07-01

    In the framework of the EU FP7 project EnerGEO (Earth Observations for Monitoring and Assessment of the Environmental Impact of Energy Use) sustainable energy potentials for forest and agricultural areas were estimated by applying three different model approaches. Firstly, the Biosphere Energy Transfer Hydrology (BETHY/DLR) model was applied to assess agricultural and forest biomass increases on a regional scale with the extension to grassland. Secondly, the EPIC (Environmental Policy Integrated Climate) - a cropping systems simulation model - was used to estimate grain yields on a global scale and thirdly the Global Forest Model (G4M) was used to estimate global woody biomass harvests and stock. The general objective of the biomass pilot is to implement the observational capacity for using biomass as an important current and future energy resource. The scope of this work was to generate biomass energy potentials for locations on the globe and to validate these data. Therefore, the biomass pilot was focused to use historical and actual remote sensing data as input data for the models. For validation purposes, forest biomass maps for 1987 and 2002 for Germany (Bundeswaldinventur (BWI-2)) and 2001 and 2008 for Austria (Austrian Forest Inventory (AFI)) were prepared as reference. (orig.)

  7. The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomas

    Energy Technology Data Exchange (ETDEWEB)

    Hakyemez, Bahattin [Uludag University School of Medicine, Department of Radiology, Gorukle, Bursa (Turkey); Bursa State Hospital, Department of Radiology, Bursa (Turkey); Yildirim, Nalan; Gokalp, Gokhan; Erdogan, Cuneyt; Parlak, Mufit [Uludag University School of Medicine, Department of Radiology, Gorukle, Bursa (Turkey)

    2006-08-15

    Atypical/malignant meningiomas recur more frequently then typical meningiomas. In this study, the contribution of diffusion-weighted MR imaging to the differentiation of atypical/malignant and typical meningiomas and to the determination of histological subtypes of typical meningiomas was investigated. The study was performed prospectively on 39 patients. The signal intensity of the lesions was evaluated on trace and apparent diffusion coefficient (ADC) images. ADC values were measured in the lesions and peritumoral edema. Student's t-test was used for statistical analysis. P<0.05 was considered statistically significant. Mean ADC values in atypical/malignant and typical meningiomas were 0.75{+-}0.21 and 1.17{+-}0.21, respectively. Mean ADC values for subtypes of typical meningiomas were as follows: meningothelial, 1.09{+-}0.20; transitional, 1.19{+-}0.07; fibroblastic, 1.29{+-}0.28; and angiomatous, 1.48{+-}0.10. Normal white matter was 0.91{+-}0.10. ADC values of typical meningiomas and atypical/malignant meningiomas significantly differed (P<0.001). However, the difference between peritumoral edema ADC values was not significant (P>0.05). Furthermore, the difference between the subtypes of typical meningiomas and atypical/malignant meningiomas was significant (P<0.001). Diffusion-weighted MR imaging findings of atypical/malignant meningiomas and typical meningiomas differ. Atypical/malignant meningiomas have lower intratumoral ADC values than typical meningiomas. Mean ADC values for peritumoral edema do not differ between typical and atypical meningiomas. (orig.)

  8. Centrifuge Study of Pilot Tolerance to Acceleration and the Effects of Acceleration on Pilot Performance

    Science.gov (United States)

    Creer, Brent Y.; Smedal, Harald A.; Wingrove, Rodney C.

    1960-01-01

    A research program the general objective of which was to measure the effects of various sustained accelerations on the control performance of pilots, was carried out on the Aviation Medical Acceleration Laboratory centrifuge, U.S. Naval Air Development Center, Johnsville, PA. The experimental setup consisted of a flight simulator with the centrifuge in the control loop. The pilot performed his control tasks while being subjected to acceleration fields such as might be encountered by a forward-facing pilot flying an atmosphere entry vehicle. The study was divided into three phases. In one phase of the program, the pilots were subjected to a variety of sustained linear acceleration forces while controlling vehicles with several different sets of longitudinal dynamics. Here, a randomly moving target was displayed to the pilot on a cathode-ray tube. For each combination of acceleration field and vehicle dynamics, pilot tracking accuracy was measured and pilot opinion of the stability and control characteristics was recorded. Thus, information was obtained on the combined effects of complexity of control task and magnitude and direction of acceleration forces on pilot performance. These tests showed that the pilot's tracking performance deteriorated markedly at accelerations greater than about 4g when controlling a lightly damped vehicle. The tentative conclusion was also reached that regardless of the airframe dynamics involved, the pilot feels that in order to have the same level of control over the vehicle, an increase in the vehicle dynamic stability was required with increases in the magnitudes of the acceleration impressed upon the pilot. In another phase, boundaries of human tolerance of acceleration were established for acceleration fields such as might be encountered by a pilot flying an orbital vehicle. A special pilot restraint system was developed to increase human tolerance to longitudinal decelerations. The results of the tests showed that human tolerance

  9. Adsorption Properties of Typical Lung Cancer Breath Gases on Ni-SWCNTs through Density Functional Theory

    Directory of Open Access Journals (Sweden)

    Qianqian Wan

    2017-01-01

    Full Text Available A lot of useful information is contained in the human breath gases, which makes it an effective way to diagnose diseases by detecting the typical breath gases. This work investigated the adsorption of typical lung cancer breath gases: benzene, styrene, isoprene, and 1-hexene onto the surface of intrinsic and Ni-doped single wall carbon nanotubes through density functional theory. Calculation results show that the typical lung cancer breath gases adsorb on intrinsic single wall carbon nanotubes surface by weak physisorption. Besides, the density of states changes little before and after typical lung cancer breath gases adsorption. Compared with single wall carbon nanotubes adsorption, single Ni atom doping significantly improves its adsorption properties to typical lung cancer breath gases by decreasing adsorption distance and increasing adsorption energy and charge transfer. The density of states presents different degrees of variation during the typical lung cancer breath gases adsorption, resulting in the specific change of conductivity of gas sensing material. Based on the different adsorption properties of Ni-SWCNTs to typical lung cancer breath gases, it provides an effective way to build a portable noninvasive portable device used to evaluate and diagnose lung cancer at early stage in time.

  10. Ensemble perception of emotions in autistic and typical children and adolescents

    Directory of Open Access Journals (Sweden)

    Themelis Karaminis

    2017-04-01

    Full Text Available Ensemble perception, the ability to assess automatically the summary of large amounts of information presented in visual scenes, is available early in typical development. This ability might be compromised in autistic children, who are thought to present limitations in maintaining summary statistics representations for the recent history of sensory input. Here we examined ensemble perception of facial emotional expressions in 35 autistic children, 30 age- and ability-matched typical children and 25 typical adults. Participants received three tasks: a an ‘ensemble’ emotion discrimination task; b a baseline (single-face emotion discrimination task; and c a facial expression identification task. Children performed worse than adults on all three tasks. Unexpectedly, autistic and typical children were, on average, indistinguishable in their precision and accuracy on all three tasks. Computational modelling suggested that, on average, autistic and typical children used ensemble-encoding strategies to a similar extent; but ensemble perception was related to non-verbal reasoning abilities in autistic but not in typical children. Eye-movement data also showed no group differences in the way children attended to the stimuli. Our combined findings suggest that the abilities of autistic and typical children for ensemble perception of emotions are comparable on average.

  11. Melodic Intonation Therapy in chronic aphasia: evidence from a pilot randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Ineke Van Der Meulen

    2016-11-01

    Full Text Available AbstractMelodic Intonation Therapy (MIT is a language production therapy for severely non-fluent aphasic patients using melodic intoning and rhythm to restore language. Although many studies have reported its beneficial effects on language production, randomized controlled trials (RCT examining the efficacy of MIT are rare. In an earlier publication, we presented the results of an RCT on MIT in subacute aphasia and found that MIT was effective on trained and untrained items. Further, we observed a clear trend in improved functional language use after MIT. Subacute aphasic patients receiving MIT improved considerably on language tasks measuring connected speech and daily life verbal communication. Here, we present the results of a pilot RCT on MIT in chronic aphasia and compare these to the results observed in subacute aphasia. We used a multicenter waiting-list randomized controlled trial design. Patients with chronic (>1 year post-stroke aphasia were randomly allocated to the experimental group (6 weeks MIT or to the control group (6 weeks no intervention followed by 6 weeks MIT. Assessments were done at baseline (T1, after 6 weeks (T2, and 6 weeks later (T3. Efficacy was evaluated at T2 using univariable linear regression analyses. Outcome measures were chosen to examine several levels of therapy success: improvement on trained items, generalization to untrained items, and generalization to verbal communication. Of 17 included patients, 10 were allocated to the experimental condition and 7 to the control condition. MIT significantly improved repetition of trained items (β=13.32, p=.02. This effect did not remain stable at follow-up assessment. In contrast to earlier studies, we found only a limited and temporary effect of MIT, without generalization to untrained material or to functional communication. The results further suggest that the effect of MIT in chronic aphasia is more restricted than its effect in earlier stages post stroke. This

  12. [Research on developping the spectral dataset for Dunhuang typical colors based on color constancy].

    Science.gov (United States)

    Liu, Qiang; Wan, Xiao-Xia; Liu, Zhen; Li, Chan; Liang, Jin-Xing

    2013-11-01

    The present paper aims at developping a method to reasonably set up the typical spectral color dataset for different kinds of Chinese cultural heritage in color rendering process. The world famous wall paintings dating from more than 1700 years ago in Dunhuang Mogao Grottoes was taken as typical case in this research. In order to maintain the color constancy during the color rendering workflow of Dunhuang culture relics, a chromatic adaptation based method for developping the spectral dataset of typical colors for those wall paintings was proposed from the view point of human vision perception ability. Under the help and guidance of researchers in the art-research institution and protection-research institution of Dunhuang Academy and according to the existing research achievement of Dunhuang Research in the past years, 48 typical known Dunhuang pigments were chosen and 240 representative color samples were made with reflective spectral ranging from 360 to 750 nm was acquired by a spectrometer. In order to find the typical colors of the above mentioned color samples, the original dataset was devided into several subgroups by clustering analysis. The grouping number, together with the most typical samples for each subgroup which made up the firstly built typical color dataset, was determined by wilcoxon signed rank test according to the color inconstancy index comprehensively calculated under 6 typical illuminating conditions. Considering the completeness of gamut of Dunhuang wall paintings, 8 complementary colors was determined and finally the typical spectral color dataset was built up which contains 100 representative spectral colors. The analytical calculating results show that the median color inconstancy index of the built dataset in 99% confidence level by wilcoxon signed rank test was 3.28 and the 100 colors are distributing in the whole gamut uniformly, which ensures that this dataset can provide reasonable reference for choosing the color with highest

  13. 46 CFR 32.90-1 - Pilot boarding equipment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Pilot boarding equipment. 32.90-1 Section 32.90-1... REQUIREMENTS Pilot Boarding Equipment § 32.90-1 Pilot boarding equipment. (a) This section applies to each... must have suitable pilot boarding equipment available for use on each side of the vessel. If a vessel...

  14. 46 CFR 78.90-1 - Pilot boarding operation.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Pilot boarding operation. 78.90-1 Section 78.90-1... Boarding Operations § 78.90-1 Pilot boarding operation. (a) The master shall ensure that pilot boarding... instructions. (b) The master shall ensure compliance with the following during pilot boarding operations: (1...

  15. 46 CFR 196.95-1 - Pilot boarding operations.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Pilot boarding operations. 196.95-1 Section 196.95-1... Pilot Boarding Operations § 196.95-1 Pilot boarding operations. (a) The master shall ensure that pilot boarding equipment is maintained as follows: (1) The equipment must be kept clean and in good working order...

  16. 46 CFR 96.40-1 - Pilot boarding equipment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Pilot boarding equipment. 96.40-1 Section 96.40-1... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Pilot Boarding Equipment § 96.40-1 Pilot boarding... boat or other vessel. (b) Each vessel must have suitable pilot boarding equipment available for use on...

  17. 46 CFR 195.40-1 - Pilot boarding equipment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Pilot boarding equipment. 195.40-1 Section 195.40-1... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Pilot Boarding Equipment § 195.40-1 Pilot boarding... boat or other vessel. (b) Each vessel must have suitable pilot boarding equipment available for use on...

  18. 46 CFR 77.40-1 - Pilot boarding equipment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Pilot boarding equipment. 77.40-1 Section 77.40-1... MISCELLANEOUS SYSTEMS AND EQUIPMENT Pilot Boarding Equipment § 77.40-1 Pilot boarding equipment. (a) This... vessel. (b) Each vessel must have suitable pilot boarding equipment available for use on each side of the...

  19. 46 CFR 97.90-1 - Pilot boarding operation.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Pilot boarding operation. 97.90-1 Section 97.90-1... OPERATIONS Pilot Boarding Operations § 97.90-1 Pilot boarding operation. (a) The master shall ensure that pilot boarding equipment is maintained as follows: (1) The equipment must be kept clean and in good...

  20. 46 CFR 35.01-55 - Pilot boarding operation.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Pilot boarding operation. 35.01-55 Section 35.01-55... Requirements § 35.01-55 Pilot boarding operation. (a) The master shall ensure that pilot boarding equipment is... instructions. (b) The master shall ensure compliance with the following during pilot boarding operations: (1...

  1. 36 CFR 223.275 - Establishment of a pilot program.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Establishment of a pilot... Establishment of a pilot program. This subpart governs the Forest Service's pilot program for the disposal of... of Title III of H.R. 3423)), as amended in 2004 by Section 335 of Public Law 108-108. The pilot...

  2. 38 CFR 21.5290 - Educational Assistance Pilot Program.

    Science.gov (United States)

    2010-07-01

    ... Pilot Program. 21.5290 Section 21.5290 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... Assistance Under 38 U.S.C. Chapter 32 Educational Assistance Pilot Program § 21.5290 Educational Assistance Pilot Program. (a) Purpose. The Educational Assistance Pilot Program is designed to encourage...

  3. 14 CFR 23.1329 - Automatic pilot system.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Automatic pilot system. 23.1329 Section 23...: Installation § 23.1329 Automatic pilot system. If an automatic pilot system is installed, it must meet the following: (a) Each system must be designed so that the automatic pilot can— (1) Be quickly and positively...

  4. 14 CFR 135.89 - Pilot requirements: Use of oxygen.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot requirements: Use of oxygen. 135.89... Operations § 135.89 Pilot requirements: Use of oxygen. (a) Unpressurized aircraft. Each pilot of an... operated with the cabin pressure altitude more than 10,000 feet MSL, each pilot shall comply with paragraph...

  5. 75 FR 51058 - Web-Distributed Labeling User Acceptance Pilot

    Science.gov (United States)

    2010-08-18

    ... Acceptance Pilot AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA's Office of...- distributed labeling ``User Acceptance Pilot'' and is soliciting interest from entities potentially willing to participate in this pilot program. Through the User Acceptance Pilot, EPA intends to demonstrate how users...

  6. 46 CFR 401.510 - Operation without Registered Pilots.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Operation without Registered Pilots. 401.510 Section 401... REGULATIONS Penalties; Operations Without Registered Pilots § 401.510 Operation without Registered Pilots. (a... Registered Pilot when the vessel or its cargo is in distress or jeopardy. (b) A vessel may be navigated in...

  7. 46 CFR 78.19-1 - Use of auto pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Use of auto pilot. 78.19-1 Section 78.19-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Auto Pilot § 78.19-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used in— (a...

  8. 46 CFR 97.16-1 - Use of auto pilot.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

  9. Contamination profile on typical printed circuit board assemblies vs soldering process

    DEFF Research Database (Denmark)

    Conseil, Helene; Jellesen, Morten Stendahl; Ambat, Rajan

    2014-01-01

    Purpose – The purpose of this paper was to analyse typical printed circuit board assemblies (PCBAs) processed by reflow, wave or selective wave soldering for typical levels of process-related residues, resulting from a specific or combination of soldering processes. Typical solder flux residue...... structure was identified by Fourier transform infrared spectroscopy, while the concentration was measured using ion chromatography, and the electrical properties of the extracts were determined by measuring the leak current using a twin platinum electrode set-up. Localized extraction of residue was carried...

  10. Prospective memory deficits in illicit polydrug users are associated with the average long-term typical dose of ecstasy typically consumed in a single session.

    Science.gov (United States)

    Gallagher, Denis T; Hadjiefthyvoulou, Florentia; Fisk, John E; Montgomery, Catharine; Robinson, Sarita J; Judge, Jeannie

    2014-01-01

    Neuroimaging evidence suggests that ecstasy-related reductions in SERT densities relate more closely to the number of tablets typically consumed per session rather than estimated total lifetime use. To better understand the basis of drug related deficits in prospective memory (p.m.) we explored the association between p.m. and average long-term typical dose and long-term frequency of use. Study 1: Sixty-five ecstasy/polydrug users and 85 nonecstasy users completed an event-based, a short-term and a long-term time-based p.m. task. Study 2: Study 1 data were merged with outcomes on the same p.m. measures from a previous study creating a combined sample of 103 ecstasy/polydrug users, 38 cannabis-only users, and 65 nonusers of illicit drugs. Study 1: Ecstasy/polydrug users had significant impairments on all p.m. outcomes compared with nonecstasy users. Study 2: Ecstasy/polydrug users were impaired in event-based p.m. compared with both other groups and in long-term time-based p.m. compared with nonillicit drug users. Both drug using groups did worse on the short-term time-based p.m. task compared with nonusers. Higher long-term average typical dose of ecstasy was associated with poorer performance on the event and short-term time-based p.m. tasks and accounted for unique variance in the two p.m. measures over and above the variance associated with cannabis and cocaine use. The typical ecstasy dose consumed in a single session is an important predictor of p.m. impairments with higher doses reflecting increasing tolerance giving rise to greater p.m. impairment.

  11. [Urban non-point source pollution control by runoff retention and filtration pilot system].

    Science.gov (United States)

    Bai, Yao; Zuo, Jian-E; Gan, Li-Li; Low, Thong Soon; Miao, Heng-Feng; Ruan, Wen-Quan; Huang, Xia

    2011-09-01

    A runoff retention and filtration pilot system was designed and the long-term purification effect of the runoff was monitored. Runoff pollution characters in 2 typical events and treatment effect of the pilot system were analyzed. The results showed that the runoff was severely polluted. Event mean concentrations (EMCs) of SS, COD, TN and TP in the runoff were 361, 135, 7.88 and 0.62 mg/L respectively. The runoff formed by long rain presented an obvious first flush effect. The first 25% flow contributed more than 50% of the total pollutants loading of SS, TP, DTP and PO4(3-). The pilot system could reduce 100% of the non-point source pollution if the volume of the runoff was less than the retention tank. Otherwise the overflow will be purification by the filtration pilot system and the removal rates of SS, COD, TN, TP, DTP and PO4(3-) reached 97.4% , 61.8%, 22.6%, 85.1%, 72.1%, and 85.2% respectively. The system was stable and the removal rate of SS, COD, TN, and TP were 98.6%, 65.4%, 55.1% and 92.6%. The whole system could effectively remove the non-point source pollution caused by runoff.

  12. Fusion pilot plant scoping study

    International Nuclear Information System (INIS)

    Gierszewski, P.J.; Blevins, P.J.; Brunnader, H.; Natalizio, A.; Cumyn, P.; Dean, B.; Smith, S.; Galambos, J.; Holloway, C.; Stremlaw, J.; Williams, G.

    1994-05-01

    CFFTP Pilot is representative of a class of machines that, like NPD in the CANDU development program, could test the key reactor core technologies on an integrated power reactor relevant system (materials, conditions, configuration). But in order to reduce costs, the machine would operate at reduced neutron flux relative to a power reactor, would not produce electricity, and would not test superconducting magnets. This design shows research directions towards a machine that could provide integrated nuclear testing (but not ignition physics) at a cost of about 1/3 ITER CDA. The test volume - the outboard blanket volume - would be comparable to the test port volume on ITER CDA, while the fluence and power density would be about 1/4 ITER CDA. 91 refs., 43 tabs., 45 figs

  13. Advanced engineering environment pilot project.

    Energy Technology Data Exchange (ETDEWEB)

    Schwegel, Jill; Pomplun, Alan R.; Abernathy, Rusty (Parametric Technology Corporation, Needham, MA)

    2006-10-01

    The Advanced Engineering Environment (AEE) is a concurrent engineering concept that enables real-time process tooling design and analysis, collaborative process flow development, automated document creation, and full process traceability throughout a product's life cycle. The AEE will enable NNSA's Design and Production Agencies to collaborate through a singular integrated process. Sandia National Laboratories and Parametric Technology Corporation (PTC) are working together on a prototype AEE pilot project to evaluate PTC's product collaboration tools relative to the needs of the NWC. The primary deliverable for the project is a set of validated criteria for defining a complete commercial off-the-shelf (COTS) solution to deploy the AEE across the NWC.

  14. Fusion pilot plant scoping study

    Energy Technology Data Exchange (ETDEWEB)

    Gierszewski, P J; Blevins, P J; Brunnader, H; Natalizio, A [Canadian Fusion Fuels Technology Project, Toronto, ON (Canada); Cumyn, P [Canatom Ltd., Montreal, PQ (Canada); Dean, B; Smith, S [Wardrop (W.L.) and Associates Ltd., Winnipeg, MB (Canada); Galambos, J [Oak Ridge National Lab., TN (United States); Holloway, C [Spar Aerospace Ltd., Toronto, ON (Canada); Stremlaw, J [Monenco AGRA Inc., Calgary, AB (Canada); Williams, G [Spectrum Engineering Corp., Peterborough, ON (Canada)

    1994-05-01

    CFFTP Pilot is representative of a class of machines that, like NPD in the CANDU development program, could test the key reactor core technologies on an integrated power reactor relevant system (materials, conditions, configuration). But in order to reduce costs, the machine would operate at reduced neutron flux relative to a power reactor, would not produce electricity, and would not test superconducting magnets. This design shows research directions towards a machine that could provide integrated nuclear testing (but not ignition physics) at a cost of about 1/3 ITER CDA. The test volume - the outboard blanket volume - would be comparable to the test port volume on ITER CDA, while the fluence and power density would be about 1/4 ITER CDA. 91 refs., 43 tabs., 45 figs.

  15. Problems pilots face involving wind shear

    Science.gov (United States)

    Melvin, W. W.

    1977-01-01

    Educating pilots and the aviation industry about wind shears presents a major problem associated with this meteorological phenomenon. The pilot's second most pressing problem is the need for a language to discuss wind shear encounters with other pilots so that the reaction of the aircraft to the wind shear encounter can be accurately described. Another problem is the flight director which gives a centered pitch command for a given angular displacement from the glide slope. It was suggested that they should instead be called flight path command and should not center unless the aircraft is actually correcting to the flight path.

  16. Pilot study for natural radiation survey

    International Nuclear Information System (INIS)

    Brown, L.; Driscoll, C.M.H.; Green, B.M.R.; Miles, J.C.H.

    1983-01-01

    NRPB's national survey of natural radiation exposure in homes commenced in 1982 and will run until 1984. A pilot survey was undertaken in over 100 homes for one year, using passive thermoluminescent dosemeters to measure external radiation from terrestrial and cosmic sources and passive radon dosemeters to measure the radon-222 gas concentration. A preliminary analysis of the results obtained from the pilot survey is given. The main value of the pilot survey was in providing experience and various administrative and scientific procedures have been simplified or automated for the national survey. (U.K.)

  17. Extractive metalurgical pilot plant. Project and installation

    International Nuclear Information System (INIS)

    Paula, H.C.B.; Rolim, T.L.; Santana, A.O. de; Santos, F.S.M. dos; Dantas, C.C.

    1986-01-01

    An extractive metalurgical pilot plant with a flow capacity of 200l/h of phosphoric leach, recovering 80% of the uranium content has been designed and installed. Starting from the diagrams of the chemical process in the laboratory scale, the equipment worksheet of the basic project were developed. The procedure for dimensioning and positioning of each component is described. An isometric figure and the pilot plant lay-out are included. The pilot plant occupying 41 m 2 has been tested and operates at its nominal capacity. (author) [pt

  18. Modelling decision-making by pilots

    Science.gov (United States)

    Patrick, Nicholas J. M.

    1993-01-01

    Our scientific goal is to understand the process of human decision-making. Specifically, a model of human decision-making in piloting modern commercial aircraft which prescribes optimal behavior, and against which we can measure human sub-optimality is sought. This model should help us understand such diverse aspects of piloting as strategic decision-making, and the implicit decisions involved in attention allocation. Our engineering goal is to provide design specifications for (1) better computer-based decision-aids, and (2) better training programs for the human pilot (or human decision-maker, DM).

  19. Pre-Study Walkthrough with a Commercial Pilot for a Preliminary Single Pilot Operations Experiment

    Science.gov (United States)

    O'Connor-Dreher, Ryan; Roberts, Z.; Ziccardi, J.; Vu, K-P. L.; Strybel, T.; Koteskey, Robert William; Lachter, Joel B.; Vi Dao, Quang; Johnson, Walter W.; Battiste, V.

    2013-01-01

    The number of crew members in commercial flights has decreased to two members, down from the five-member crew required 50 years ago. One question of interest is whether the crew should be reduced to one pilot. In order to determine the critical factors involved in safely transitioning to a single pilot, research must examine whether any performance deficits arise with the loss of a crew member. With a concrete understanding of the cognitive and behavioral role of a co-pilot, aeronautical technologies and procedures can be developed that make up for the removal of the second aircrew member. The current project describes a pre-study walkthrough process that can be used to help in the development of scenarios for testing future concepts and technologies for single pilot operations. Qualitative information regarding the tasks performed by the pilots can be extracted with this technique and adapted for future investigations of single pilot operations.

  20. Brief Report: A Pilot Summer Robotics Camp to Reduce Social Anxiety and Improve Social/Vocational Skills in Adolescents with ASD

    Science.gov (United States)

    Kaboski, Juhi R.; Diehl, Joshua John; Beriont, Jane; Crowell, Charles R.; Villano, Michael; Wier, Kristin; Tang, Karen

    2015-01-01

    This pilot study evaluated a novel intervention designed to reduce social anxiety and improve social/vocational skills for adolescents with autism spectrum disorder (ASD). The intervention utilized a shared interest in robotics among participants to facilitate natural social interaction between individuals with ASD and typically developing (TD)…

  1. ISO New England: Results of Ancillary Service Pilot Programs, Alternative Technology Regulation Pilot Program and Demand Response Reserves Pilot Program

    Energy Technology Data Exchange (ETDEWEB)

    Lowell, Jon [ISO New England, Holyoke, MA (United States); Yoshimura, Henry [ISO New England, Holyoke, MA (United States)

    2011-10-26

    This PowerPoint presentation compares performance of pilot program assets and generation resources in alternative technology regulation and demand response reserves for flywheels and residential electric thermal storage.

  2. Land Cover Change Monitoring of Typical Functional Communities of Sichuan Province Based on ZY-3 Data

    Science.gov (United States)

    Li, G. M.; Li, S.; Ying, G. W.; Wu, X. P.

    2018-04-01

    According to the function, land space types are divided into key development areas, restricted development areas and forbidden development areas in Sichuan Province. This paper monitors and analyses the changes of land cover in different typical functional areas from 2010 to 2017, which based on ZY-3 high-score images data and combined with statistical yearbook and thematic data of Sichuan Province. The results show that: The land cover types of typical key development zones are mainly composed of cultivated land, forest land, garden land, and housing construction land, which accounts for the total area of land cover 87 %. The land cover types of typical restricted development zone mainly consists of forest land and grassland, which occupy 97.71 % of the total area of the surface coverage. The land cover types of the typical prohibition development zone mainly consist of forest land, grassland, desert and bared earth, which accounts for the total area of land cover 99.31 %.

  3. INVESTIGATION OF SEISMIC PERFORMANCE AND DESIGN OF TYPICAL CURVED AND SKEWED BRIDGES IN COLORADO

    Science.gov (United States)

    2018-01-15

    This report summarizes the analytical studies on the seismic performance of typical Colorado concrete bridges, particularly those with curved and skewed configurations. A set of bridge models with different geometric configurations derived from a pro...

  4. Gender Norm Salience Across Middle Schools: Contextual Variations in Associations Between Gender Typicality and Socioemotional Distress.

    Science.gov (United States)

    Smith, Danielle Sayre; Schacter, Hannah L; Enders, Craig; Juvonen, Jaana

    2018-05-01

    Youth who feel they do not fit with gender norms frequently experience peer victimization and socioemotional distress. To gauge differences between schools, the current study examined the longitudinal effects of school-level gender norm salience-a within-school association between gender typicality and peer victimization-on socioemotional distress across 26 ethnically diverse middle schools (n boys  = 2607; n girls  = 2805). Boys (but not girls) reporting lower gender typicality experienced more loneliness and social anxiety in schools with more salient gender norms, even when accounting for both individual and school level victimization. Greater gender norm salience also predicted increased depressed mood among boys regardless of gender typicality. These findings suggest particular sensitivity among boys to environments in which low gender typicality is sanctioned.

  5. METHODS OF THE APPROXIMATE ESTIMATIONS OF FATIGUE DURABILITY OF COMPOSITE AIRFRAME COMPONENT TYPICAL ELEMENTS

    Directory of Open Access Journals (Sweden)

    V. E. Strizhius

    2015-01-01

    Full Text Available Methods of the approximate estimations of fatigue durability of composite airframe component typical elements which can be recommended for application at the stage of outline designing of the airplane are generated and presented.

  6. Pilot-model measurements of pilot responses in a lateral-directional control task

    Science.gov (United States)

    Adams, J. J.

    1976-01-01

    Pilot response during an aircraft bank-angle compensatory control task was measured by using an adaptive modeling technique. In the main control loop, which is the bank angle to aileron command loop, the pilot response was the same as that measured previously in single-input, single-output systems. The pilot used a rudder to aileron control coordination that canceled up to 80 percent of the vehicle yawing moment due to aileron deflection.

  7. Pilot and pilot-commercial plants for reprocessing spent fuels of FBR type reactors

    International Nuclear Information System (INIS)

    Shaldaev, V.S.; Sokolova, I.D.

    1988-01-01

    A review of modern state of investigations on the FBR mixed oxide uranium-plutonium fuel reprocessing abroad is given. Great Britain and France occupy the leading place in this field, operating pilot plants of 5 tons a year capacity. Technology of spent fuel reprocessing and specific features of certain stages of the technological process are considered. Projects of pilot and pilot-commercial plants of Great Britain, France, Japan, USA are described. Economic problems of the FBR fuel reprocessing are touched upon

  8. Pilot Certification, Age of Pilot, and Drug Use in Fatal Civil Aviation Accidents.

    Science.gov (United States)

    Akparibo, Issaka Y; Stolfi, Adrienne

    2017-10-01

    This study examined the association between mean age of pilot, pilot license, pilot medical certificate and drug use trends in pilots fatally injured in aircraft accidents. The prevalence of prescription drugs, OTC drugs, controlled drugs and drugs that may be potentially impairing was also examined. This study was a descriptive observational study in which the NTSB Aviation Accident Database was searched from the period beginning January 1, 2012 to December 31, 2014. During the study period a total of 706 accidents involving 711 fatalities were investigated by the NTSB. This study included 633 of these accidents, involving 646 fatalities. Of these pilots, 42.1% had drugs in their biological samples. The prevalence of prescription drugs, controlled drugs, OTC drugs, opioids, and potentially impairing drugs in the fatally injured pilot population over the study period was 28.9%, 15.0%, 20.1%, 5.1%, and 25.5%, respectively. Pilots with any drugs in their samples were significantly older than those without drugs. Medical certificate held was associated with drug use; pilots who held third class certificates had the highest prevalence at 54.1%. Pilot license was not associated with drug use. In 3.8% of the accidents, drugs were a contributing factor in the cause. Despite current FAA medical regulations, potentially impairing drugs are frequently found in biological samples of fatally injured pilots in the U.S. More education of airmen by aviation medical examiners is needed on the safety of drug use.Akparibo IY, Stolfi A. Pilot certification, age of pilot, and drug use in fatal civil aviation accidents. Aerosp Med Hum Perform. 2017; 88(10):931-936.

  9. Predicting Active Duty Air Force Pilot Attrition Given an Anticipated Increase in Major Airline Pilot Hiring

    Science.gov (United States)

    2015-01-01

    the Air Force in addressing some quality-of-life issues, such as updating 3,800 family housing units, 21 dormitories, and building three child ...of pilots into the airlines (Air Force Personnel Center, FY 07). By allowing this crop of pilots to leave on the Air Force’s terms, the service felt...attrition rates compared with pilots with more general skills (flying mobility aircraft) (Stephen P. Barrows, 1993). This may be due to the phenomenon in

  10. Determinants of Occupational Gender Segregation : Work Values and Gender (A)Typical Occupational Preferences of Adolescents

    OpenAIRE

    Busch, Anne

    2011-01-01

    The study examines micro-level determinants of the occupational gender segregation, analyzing work values and their effects on gender (a)typical occupational preferences of adolescents. Human capital theory assumes that women develop higher preferences for a good work/life balance in youth, whereas men develop higher extrinsic work values. Socialization theory predicts that female adolescents form higher preferences for social work content. This gender typicality in work values is expected to...

  11. Ecosystem responses to warming and watering in typical and desert steppes

    OpenAIRE

    Zhenzhu Xu; Yanhui Hou; Lihua Zhang; Tao Liu; Guangsheng Zhou

    2016-01-01

    Global warming is projected to continue, leading to intense fluctuations in precipitation and heat waves and thereby affecting the productivity and the relevant biological processes of grassland ecosystems. Here, we determined the functional responses to warming and altered precipitation in both typical and desert steppes. The results showed that watering markedly increased the aboveground net primary productivity (ANPP) in a typical steppe during a drier year and in a desert steppe over two ...

  12. A COMPARISON OF SOCIAL SKILLS OF STUDENTS WITH VISUAL IMPAIRMENTS AND TYPICALLY DEVELOPING STUDENTS

    OpenAIRE

    Demir, Fatih Emrah; Ozdemir, Selda

    2016-01-01

    The purpose of this study was to compare the social skills of students with visual impairments with social skills of typically developing students. The study groups consisted of 64 students with visual impairments and 68 typically developing students from the first to fourth grade. The Social Skills Rating System (SSRS) Teacher Form was used to evaluate the social skills of both groups. The results of the study indicated that cooperation, assertiveness, and self-control sub-scale scores and o...

  13. Study on the knowledge base system for the identification of typical target

    International Nuclear Information System (INIS)

    Qin Kai; Zhao Yingjun

    2008-01-01

    Based on the research on target knowledge base, target database, texture analysis, shape analysis, this paper proposed a new knowledge based method for typical target identification from remote sensing image. By extracting the texture characters and shape characters, joining with spatial analysis in GIS, reasoning according to the prior knowledge in the knowledge base, this method can identify and ex- tract typical target from remote sensing images. (authors)

  14. Maternal and paternal pragmatic speech directed to young children with Down syndrome and typical development

    OpenAIRE

    de Falco, Simona; Venuti, Paola; Esposito, Gianluca; Bornstein, Marc H.

    2011-01-01

    The aim of this study was to compare functional features of maternal and paternal speech directed to children with Down syndrome and developmental age-matched typically developing children. Altogether 88 parents (44 mothers and 44 fathers) and their 44 young children (22 children with Down syndrome and 22 typically developing children) participated. Parents’ speech directed to children was obtained through observation of naturalistic parent–child dyadic interactions. Verbatim transcripts of m...

  15. A Fast Implementation for the Typical Testor Property Identification Based on an Accumulative Binary Tuple

    Directory of Open Access Journals (Sweden)

    Guillermo Sanchez-Diaz

    2012-11-01

    Full Text Available In this paper, we introduce a fast implementation of the CT EXT algorithm for testor property identification, that is based on an accumulative binary tuple. The fast implementation of the CT EXT algorithm (one of the fastest algorithms reported, is designed to generate all the typical testors from a training matrix, requiring a reduced number of operations. Experimental results using this fast implementation and the comparison with other state-of-the-art algorithms that generate typical testors are presented.

  16. Frequency of celiac disease in adult patients with typical or atypical malabsorption symptoms in isfahan, iran.

    Science.gov (United States)

    Emami, Mohammad Hassan; Kouhestani, Soheila; Karimi, Somayeh; Baghaei, Abdolmahdi; Janghorbani, Mohsen; Jamali, Nahid; Gholamrezaei, Ali

    2012-01-01

    Aim. Atypical presentations of celiac disease (CD) have now been shown to be much more common than classical (typical) form. We evaluated the frequency of CD among adult patients with typical or atypical symptoms of CD. Materials and Methods. Patients referred to two outpatient gastroenterology clinics in Isfahan (IRAN) were categorized into those with typical or atypical symptoms of CD. IgA antitissue transglutaminase antibody was assessed and followed by duodenal biopsy. In patients for whom endoscopy was indicated (independent of the serology), duodenal biopsy was taken. Histopathological changes were assessed according to the Marsh classification. Results. During the study period, 151 and 173 patients with typical and atypical symptoms were evaluated (mean age = 32.8 ± 12.6 and 35.8 ± 14.8 years, 47.0% and 56.0% female, resp.). Frequency of CD in patients with typical and atypical symptoms was calculated, respectively, as 5.9% (9/151) and 1.25% (3/173) based on positive serology and pathology. The overall frequency was estimated as at least 9.2% (14/151) and 4.0% (7/173) when data of seronegative patients were also considered. Conclusions. CD is more frequent among patients with typical symptoms of malabsorption and these patients should undergo duodenal biopsy, irrespective of the serology. In patients with atypical symptoms, serological tests should be performed followed by endoscopic biopsy, and routine duodenal biopsy is recommended when endoscopic evaluation is indicated because of symptoms.

  17. The influence of gender and gender typicality on autobiographical memory across event types and age groups.

    Science.gov (United States)

    Grysman, Azriel; Fivush, Robyn; Merrill, Natalie A; Graci, Matthew

    2016-08-01

    Gender differences in autobiographical memory emerge in some data collection paradigms and not others. The present study included an extensive analysis of gender differences in autobiographical narratives. Data were collected from 196 participants, evenly split by gender and by age group (emerging adults, ages 18-29, and young adults, ages 30-40). Each participant reported four narratives, including an event that had occurred in the last 2 years, a high point, a low point, and a self-defining memory. Additionally, all participants completed self-report measures of masculine and feminine gender typicality. The narratives were coded along six dimensions-namely coherence, connectedness, agency, affect, factual elaboration, and interpretive elaboration. The results indicated that females expressed more affect, connection, and factual elaboration than males across all narratives, and that feminine typicality predicted increased connectedness in narratives. Masculine typicality predicted higher agency, lower connectedness, and lower affect, but only for some narratives and not others. These findings support an approach that views autobiographical reminiscing as a feminine-typed activity and that identifies gender differences as being linked to categorical gender, but also to one's feminine gender typicality, whereas the influences of masculine gender typicality were more context-dependent. We suggest that implicit gendered socialization and more explicit gender typicality each contribute to gendered autobiographies.

  18. Effects of temperature and mass conservation on the typical chemical sequences of hydrogen oxidation

    Science.gov (United States)

    Nicholson, Schuyler B.; Alaghemandi, Mohammad; Green, Jason R.

    2018-01-01

    Macroscopic properties of reacting mixtures are necessary to design synthetic strategies, determine yield, and improve the energy and atom efficiency of many chemical processes. The set of time-ordered sequences of chemical species are one representation of the evolution from reactants to products. However, only a fraction of the possible sequences is typical, having the majority of the joint probability and characterizing the succession of chemical nonequilibrium states. Here, we extend a variational measure of typicality and apply it to atomistic simulations of a model for hydrogen oxidation over a range of temperatures. We demonstrate an information-theoretic methodology to identify typical sequences under the constraints of mass conservation. Including these constraints leads to an improved ability to learn the chemical sequence mechanism from experimentally accessible data. From these typical sequences, we show that two quantities defining the variational typical set of sequences—the joint entropy rate and the topological entropy rate—increase linearly with temperature. These results suggest that, away from explosion limits, data over a narrow range of thermodynamic parameters could be sufficient to extrapolate these typical features of combustion chemistry to other conditions.

  19. Advanced software tool for the creation of a typical meteorological year

    International Nuclear Information System (INIS)

    Skeiker, Kamal; Ghani, Bashar Abdul

    2008-01-01

    The generation of a typical meteorological year is of great importance for calculations concerning many applications in the field of thermal engineering. In this context, method that has been proposed by Hall et al. is selected for generating typical data, and an improved criterion for final selection of typical meteorological month (TMM) was demonstrated. The final selection of the most representative year was done by examining a composite score S. The composite score was calculated as the weighed sum of the scores of the four meteorological parameters used. These parameters are air dry bulb temperature, relative humidity, wind velocity and global solar radiation intensity. Moreover, a new modern software tool using Delphi 6.0 has been developed, utilizing the Filkenstein-Schafer statistical method for the creation of a typical meteorological year for any site of concern. Whereas, an improved criterion for final selection of typical meteorological month was employed. Such tool allows the user to perform this task without an intimate knowledge of all of the computational details. The final alphanumerical and graphical results are presented on screen, and can be saved to a file or printed as a hard copy. Using this software tool, a typical meteorological year was generated for Damascus, capital of Syria, as a test run example. The data processed used were obtained from the Department of Meteorology and cover a period of 10 years (1991-2000)

  20. Frequency of Celiac Disease in Adult Patients with Typical or Atypical Malabsorption Symptoms in Isfahan, Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Emami

    2012-01-01

    Full Text Available Aim. Atypical presentations of celiac disease (CD have now been shown to be much more common than classical (typical form. We evaluated the frequency of CD among adult patients with typical or atypical symptoms of CD. Materials and Methods. Patients referred to two outpatient gastroenterology clinics in Isfahan (IRAN were categorized into those with typical or atypical symptoms of CD. IgA antitissue transglutaminase antibody was assessed and followed by duodenal biopsy. In patients for whom endoscopy was indicated (independent of the serology, duodenal biopsy was taken. Histopathological changes were assessed according to the Marsh classification. Results. During the study period, 151 and 173 patients with typical and atypical symptoms were evaluated (mean age = 32.8±12.6 and 35.8±14.8 years, 47.0% and 56.0% female, resp.. Frequency of CD in patients with typical and atypical symptoms was calculated, respectively, as 5.9% (9/151 and 1.25% (3/173 based on positive serology and pathology. The overall frequency was estimated as at least 9.2% (14/151 and 4.0% (7/173 when data of seronegative patients were also considered. Conclusions. CD is more frequent among patients with typical symptoms of malabsorption and these patients should undergo duodenal biopsy, irrespective of the serology. In patients with atypical symptoms, serological tests should be performed followed by endoscopic biopsy, and routine duodenal biopsy is recommended when endoscopic evaluation is indicated because of symptoms.

  1. Analysis of Pilot-Induced-Oscillation and Pilot Vehicle System Stability Using UAS Flight Experiments

    Directory of Open Access Journals (Sweden)

    Tanmay K. Mandal

    2016-11-01

    Full Text Available This paper reports the results of a Pilot-Induced Oscillation (PIO and human pilot control characterization study performed using flight data collected with a Remotely Controlled (R/C unmanned research aircraft. The study was carried out on the longitudinal axis of the aircraft. Several existing Category 1 and Category 2 PIO criteria developed for manned aircraft are first surveyed and their effectiveness for predicting the PIO susceptibility for the R/C unmanned aircraft is evaluated using several flight experiments. It was found that the Bandwidth/Pitch rate overshoot and open loop onset point (OLOP criteria prediction results matched flight test observations. However, other criteria failed to provide accurate prediction results. To further characterize the human pilot control behavior during these experiments, a quasi-linear pilot model is used. The parameters of the pilot model estimated using data obtained from flight tests are then used to obtain information about the stability of the Pilot Vehicle System (PVS for Category 1 PIOs occurred during straight and level flights. The batch estimation technique used to estimate the parameters of the quasi-linear pilot model failed to completely capture the compatibility nature of the human pilot. The estimation results however provided valuable insights into the frequency characteristics of the human pilot commands. Additionally, stability analysis of the Category 2 PIOs for elevator actuator rate limiting is carried out using simulations and the results are compared with actual flight results.

  2. Pilot Designed Aircraft Displays in General Aviation: An Exploratory Study and Analysis

    Science.gov (United States)

    Conaway, Cody R.

    From 2001-2011, the General Aviation (GA) fatal accident rate remained unchanged (Duquette & Dorr, 2014) with an overall stagnant accident rate between 2004 and 2013. The leading cause, loss of control in flight (NTSB, 2015b & 2015c) due to pilot inability to recognize approach to stall/spin conditions (NTSB, 2015b & 2016b). In 2013, there were 1,224 GA accidents in the U.S., accounting for 94% of all U.S. aviation accidents and 90% of all U.S. aviation fatalities that year (NTSB, 2015c). Aviation entails multiple challenges for pilots related to task management, procedural errors, perceptual distortions, and cognitive discrepancies. While machine errors in airplanes have continued to decrease over the years, human error still has not (NTSB, 2013). A preliminary analysis of a PC-based, Garmin G1000 flight deck was conducted with 3 professional pilots. Analyses revealed increased task load, opportunities for distraction, confusing perceptual ques, and hindered cognitive performance. Complex usage problems were deeply ingrained in the functionality of the system, forcing pilots to use fallible work arounds, add unnecessary steps, and memorize knob turns or button pushes. Modern computing now has the potential to free GA cockpit designs from knobs, soft keys, or limited display options. Dynamic digital displays might include changes in instrumentation or menu structuring depending on the phase of flight. Airspeed indicators could increase in size to become more salient during landing, simultaneously highlighting pitch angle on Attitude Indicators and automatically decluttering unnecessary information for landing. Likewise, Angle-of-Attack indicators demonstrate a great safety and performance advantage for pilots (Duquette & Dorr, 2014; NTSB, 2015b & 2016b), an instrument typically found in military platforms and now the Icon A5, light-sport aircraft (Icon, 2016). How does the design of pilots' environment---the cockpit---further influence their efficiency and

  3. Humboldt SK pilot biodigester receives funding

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2005-09-30

    The Canada-Saskatchewan Western Economic Partnership Agreement (WEPA) will provide funding for Canada's first pilot-scale biodigester to be built in Humboldt, Saskatchewan. The $208,138 pilot facility will use household garbage as well as agricultural waste such as manure and livestock operations, abattoirs and food processing to create heat or power and fertilizer. Support for this bio-energy facility, which could also reduce greenhouse gases, will come from the Prairie Agricultural Machinery Institute which has received $186,138 from Canada and Saskatchewan in the form of cost-shared federal-provincial funding. The pilot plant will test different combinations of waste material feedstocks and the characteristics of the resulting gas end products. The pilot facility will also provide design information for full-scale biodigester manufacturers in Canada. It is expected that 25 full-scale biodigesters will be constructed in Canada in the near future.

  4. New Orleans Capacity Building Pilot Project

    Science.gov (United States)

    A series of meetings involving the Port of New Orleans and near-port community organizations were convened for a community capacity building pilot project. Technical assistance is being provided by EPA to support effective engagement.

  5. Electronic Government : Caribbean Pilot Project | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Electronic Government : Caribbean Pilot Project. Caribbean countries are increasingly adopting information and communication technologies (ICTs) in ... The Government of Jamaica is willing to donate the solution to other ... Related content ...

  6. Wyoming CV Pilot Traveler Information Message Sample

    Data.gov (United States)

    Department of Transportation — This dataset contains a sample of the sanitized Traveler Information Messages (TIM) being generated by the Wyoming Connected Vehicle (CV) Pilot. The full set of TIMs...

  7. Value pricing pilot program : lessons learned

    Science.gov (United States)

    2008-08-01

    This "Lessons Learned Report" provides a summary of projects sponsored by the Federal Highway Administration's (FHWA's) Congestion and Value Pricing Pilot Programs from 1991 through 2006 and draws lessons from a sample of projects with the richest an...

  8. Design of a uranium recovery pilot plant

    International Nuclear Information System (INIS)

    1984-01-01

    The engineering design of a pilot plant of uranium recover, is presented. The diagrams and specifications of the equipments such as pipelines, pumps, values tanks, filters, engines, etc... as well as metallic structure and architetonic design is also presented. (author)

  9. Video - Personal Competence Manager (Digital Cinema pilot)

    NARCIS (Netherlands)

    Santos, Patricia

    2008-01-01

    Video demonstrating the PCM (version year 2007) in the context of the Digital Cinema pilot. Elaborated for a eLearning Seminar within the International Master on Communication and Education (Autonomous University of Barcelona, academic year 2008)

  10. LHCb: Pilot Framework and the DIRAC WMS

    CERN Multimedia

    Graciani, R; Casajus, A

    2009-01-01

    DIRAC, the LHCb community Grid solution, has pioneered the use of pilot jobs in the Grid. Pilot jobs provide a homogeneous interface to an heterogeneous set of computing resources. At the same time, pilot jobs allow to delay the scheduling decision to the last moment, thus taking into account the precise running conditions at the resource and last moment requests to the system. The DIRAC Workload Management System provides one single scheduling mechanism for jobs with very different profiles. To achieve an overall optimisation, it organizes pending jobs in task queues, both for individual users and production activities. Task queues are created with jobs having similar requirements. Following the VO policy a priority is assigned to each task queue. Pilot submission and subsequent job matching are based on these priorities following a statistical approach. Details of the implementation and the security aspects of this framework will be discussed.

  11. 2000 Pilot Environmental Sustainability Index (ESI)

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2000 Pilot Environmental Sustainability Index (ESI) is an exploratory effort to construct an index that measures the ability of a nation's economy to achieve...

  12. Resource Conservation and Recovery Act, Part B permit application [of the Waste Isolation Pilot Plant (WIPP)]. Volume 11, Chapter D, Appendix D4--Chapter D, Appendix D17: Revision 3

    Energy Technology Data Exchange (ETDEWEB)

    1993-03-01

    This volume contains appendices D4 through D17 which cover the following: Waste Isolation Pilot Plant site environmental report; ecological monitoring program at the Waste Isolation Pilot Plant; site characterization; regional and site geology and hydrology; general geology; dissolution features; ground water hydrology; typical carbon sorption bed efficiency; VOC monitoring plan for bin-room tests; chemical compatibility analysis of waste forms and container materials; probable maximum precipitation; WHIP supplementary roof support system room 1, panel 1; and corrosion risk assessment of the Waste Isolation Pilot Plant ``humid`` test bins.

  13. Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia

    Directory of Open Access Journals (Sweden)

    Swartz Marvin

    2006-02-01

    Full Text Available Abstract Background There is an ongoing debate over whether atypical antipsychotics are more effective than typical antipsychotics in the treatment of schizophrenia. This naturalistic study compares atypical and typical antipsychotics on time to all-cause medication discontinuation, a recognized index of medication effectiveness in the treatment of schizophrenia. Methods We used data from a large, 3-year, observational, non-randomized, multisite study of schizophrenia, conducted in the U.S. between 7/1997 and 9/2003. Patients who were initiated on oral atypical antipsychotics (clozapine, olanzapine, risperidone, quetiapine, or ziprasidone or oral typical antipsychotics (low, medium, or high potency were compared on time to all-cause medication discontinuation for 1 year following initiation. Treatment group comparisons were based on treatment episodes using 3 statistical approaches (Kaplan-Meier survival analysis, Cox Proportional Hazards regression model, and propensity score-adjusted bootstrap resampling methods. To further assess the robustness of the findings, sensitivity analyses were performed, including the use of (a only 1 medication episode for each patient, the one with which the patient was treated first, and (b all medication episodes, including those simultaneously initiated on more than 1 antipsychotic. Results Mean time to all-cause medication discontinuation was longer on atypical (N = 1132, 256.3 days compared to typical antipsychotics (N = 534, 197.2 days; p Conclusion In the usual care of schizophrenia patients, time to medication discontinuation for any cause appears significantly longer for atypical than typical antipsychotics regardless of the typical antipsychotic potency level. Findings were primarily driven by clozapine and olanzapine, and to a lesser extent by risperidone. Furthermore, only clozapine and olanzapine therapy showed consistently and significantly longer treatment duration compared to perphenazine, a medium

  14. Biodegradation of di(2-ethylhexyl)phthalate in a typical tropical soil

    Energy Technology Data Exchange (ETDEWEB)

    Castelo de Moura Carrara, Silvia Marta; Morita, Dione Mari [Polytechnic School, University of Sao Paulo (Brazil); Boscov, Maria Eugenia Gimenez, E-mail: meboscov@usp.br [Polytechnic School, University of Sao Paulo (Brazil)

    2011-12-15

    Highlights: Black-Right-Pointing-Pointer Scarce literature on contamination of tropical soils by phthalates. Black-Right-Pointing-Pointer Investigation of mobility of DEHP in a tropical soil by infiltration tests showed that DEHP is retained in the upper layer of the soil. Black-Right-Pointing-Pointer Low air and water permeability indicate that in situ bioremediation is not feasible for this soil. Black-Right-Pointing-Pointer Respirometric tests were inadequate to investigate biodegradation because tropical soils are acidic. Black-Right-Pointing-Pointer Slurry-phase reactor with cement mixer provided significant biodegradation (99% in 49 days). - Abstract: The aim of this research was to evaluate the possibility of biodegradation of di(2-ethylhexyl)phthalate (DEHP), widely used as an industrial plasticizer and considered an endocrine-disrupting chemical included in the U.S. Environmental Protection Agency priority list, in a Brazilian tropical soil, which has not been previously reported in the literature, despite the geographic importance of tropical soils. Preliminary laboratory testing comprised respirometric, air and water permeability, and pilot scale infiltration tests. Standard respirometric tests were found inadequate for studying biodegradation in tropical contaminated soils, due to the effect of the addition of significant amounts of calcium carbonate, necessary to adjust soil pH. Pilot scale infiltration tests performed for 5 months indicated that DEHP was retained in the superficial layer of the soil, barely migrating downwards, whereas air and water permeability tests discarded in situ bioremediation. However, ex situ bioremediation was possible, using a slurry-phase reactor with acclimated microorganisms, in pilot scale tests conducted to remediate a total mass of 150 kg of contaminated soil with 100 mg DEHP/kg. The removal of DEHP in the slurry-phase reactor achieved the percentage of 99% in 49 days, with biodegradation following a first

  15. Study on the three-station typical network deployments of workspace Measurement and Positioning System

    Science.gov (United States)

    Xiong, Zhi; Zhu, J. G.; Xue, B.; Ye, Sh. H.; Xiong, Y.

    2013-10-01

    As a novel network coordinate measurement system based on multi-directional positioning, workspace Measurement and Positioning System (wMPS) has outstanding advantages of good parallelism, wide measurement range and high measurement accuracy, which makes it to be the research hotspots and important development direction in the field of large-scale measurement. Since station deployment has a significant impact on the measurement range and accuracy, and also restricts the use-cost, the optimization method of station deployment was researched in this paper. Firstly, positioning error model was established. Then focusing on the small network consisted of three stations, the typical deployments and error distribution characteristics were studied. Finally, through measuring the simulated fuselage using typical deployments at the industrial spot and comparing the results with Laser Tracker, some conclusions are obtained. The comparison results show that under existing prototype conditions, I_3 typical deployment of which three stations are distributed in a straight line has an average error of 0.30 mm and the maximum error is 0.50 mm in the range of 12 m. Meanwhile, C_3 typical deployment of which three stations are uniformly distributed in the half-circumference of an circle has an average error of 0.17 mm and the maximum error is 0.28 mm. Obviously, C_3 typical deployment has a higher control effect on precision than I_3 type. The research work provides effective theoretical support for global measurement network optimization in the future work.

  16. The influence of thematic congruency, typicality and divided attention on memory for radio advertisements.

    Science.gov (United States)

    Martín-Luengo, Beatriz; Luna, Karlos; Migueles, Malen

    2014-01-01

    We examined the effects of the thematic congruence between ads and the programme in which they are embedded. We also studied the typicality of the to-be-remembered information (high- and low-typicality elements), and the effect of divided attention in the memory for radio ad contents. Participants listened to four radio programmes with thematically congruent and incongruent ads embedded, and completed a true/false recognition test indicating the level of confidence in their answer. Half of the sample performed an additional task (divided attention group) while listening to the radio excerpts. In general, recognition memory was better for incongruent ads and low-typicality statements. Confidence in hits was higher in the undivided attention group, although there were no differences in performance. Our results suggest that the widespread idea of embedding ads into thematic-congruent programmes negatively affects memory for ads. In addition, low-typicality features that are usually highlighted by advertisers were better remembered than typical contents. Finally, metamemory evaluations were influenced by the inference that memory should be worse if we do several things at the same time.

  17. Celiac disease in 87 children with typical and atypical symptoms in Black Sea region of Turkey.

    Science.gov (United States)

    Dinler, Gönül; Atalay, Erdal; Kalayci, Ayhan Gazi

    2009-11-01

    Celiac disease presents with a spectrum of clinical disorders. The variety of clinical presentations largely depends on age and extraintestinal findings. This study aimed to determine typical and atypical cases according to presenting symptoms and to evaluate their biochemical and pathological parameters. Eighty-seven patients with celiac disease in our unit between 2000 and 2007 were reviewed. Their diagnosis was made by serological and histological examination. The patients were divided into two groups according to their typical or atypical symptoms. The mean age of the patients at diagnosis was 8.2 years (range, 1-18 years), but patients presenting with typical symptoms were younger than those presenting with atypical symptoms. The patients in the two groups did not differ significantly in sex, weight and height Z scores except age. Diarrhea (96.3%), abdominal distention (65.4%) and failure to thrive (60%) were the most common clinical presentations in the typical group, and short stature (62.5%) and anemia (31.2%) were the most common in the atypical group. Total/subtotal villous atrophy was significantly higher in the typical group than in the atypical group. Many children with celiac disease show an atypical form. The understanding of presentations of celiac disease may prevent delayed diagnosis. Celiac disease should be specially investigated in patients with recurrent iron deficiency anemia, short stature and autoimmune disorders.

  18. Typical Versus Atypical Anorexia Nervosa Among Adolescents: Clinical Characteristics and Implications for ICD-11.

    Science.gov (United States)

    Silén, Yasmina; Raevuori, Anu; Jüriloo, Elisabeth; Tainio, Veli-Matti; Marttunen, Mauri; Keski-Rahkonen, Anna

    2015-09-01

    There is scant research on the clinical utility of differentiating International Classification of Diseases (ICD) 10 diagnoses F50.0 anorexia nervosa (typical AN) and F50.1 atypical anorexia. We reviewed systematically records of 47 adolescents who fulfilled criteria for ICD-10 F50.0 (n = 34) or F50.1 (n = 13), assessing the impact of diagnostic subtype, comorbidity, background factors and treatment choices on recovery. Atypical AN patients were significantly older (p = 0.03), heavier (minimum body mass index 16.7 vs 15.1 kg/m(2) , p = 0.003) and less prone to comorbidities (38% vs 71%, p = 0.04) and had shorter, less intensive and less costly treatments than typical AN patients. The diagnosis of typical versus atypical AN was the sole significant predictor of treatment success: recovery from atypical AN was 4.3 times (95% confidence interval [1.1, 17.5]) as likely as recovery from typical AN. Overall, our findings indicate that a broader definition of AN may dilute the prognostic value of the diagnosis, and therefore, ICD-11 should retain its distinction between typical and atypical AN. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.

  19. Clinical correlates of parenting stress in children with Tourette syndrome and in typically developing children.

    Science.gov (United States)

    Stewart, Stephanie B; Greene, Deanna J; Lessov-Schlaggar, Christina N; Church, Jessica A; Schlaggar, Bradley L

    2015-05-01

    To determine the impact of tic severity in children with Tourette syndrome on parenting stress and the impact of comorbid attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) symptomatology on parenting stress in both children with Tourette syndrome and typically developing children. Children with diagnosed Tourette syndrome (n=74) and tic-free typically developing control subjects (n=48) were enrolled in a cross-sectional study. Parenting stress was greater in the group with Tourette syndrome than the typically developing group. Increased levels of parenting stress were related to increased ADHD symptomatology in both children with Tourette syndrome and typically developing children. Symptomatology of OCD was correlated with parenting stress in Tourette syndrome. Parenting stress was independent of tic severity in patients with Tourette syndrome. For parents of children with Tourette syndrome, parenting stress appears to be related to the child's ADHD and OCD comorbidity and not to the severity of the child's tic. Subthreshold ADHD symptomatology also appears to be related to parenting stress in parents of typically developing children. These findings demonstrate that ADHD symptomatology impacts parental stress both in children with and without a chronic tic disorder. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. One for all: The effect of extinction stimulus typicality on return of fear.

    Science.gov (United States)

    Scheveneels, Sara; Boddez, Yannick; Bennett, Marc Patrick; Hermans, Dirk

    2017-12-01

    During exposure therapy, patients are encouraged to approach the feared stimulus, so they can experience that this stimulus is not followed by the anticipated aversive outcome. However, patients might treat the absence of the aversive outcome as an 'exception to the rule'. This could hamper the generalization of fear reduction when the patient is confronted with similar stimuli not used in therapy. We examined the effect of providing information about the typicality of the extinction stimulus on the generalization of extinction to a new but similar stimulus. In a differential fear conditioning procedure, an animal-like figure was paired with a brief electric shock to the wrist. In a subsequent extinction phase, a different but perceptually similar animal-like figure was presented without the shock. Before testing the generalization of extinction with a third animal-like figure, participants were either instructed that the extinction stimulus was a typical or an atypical member of the animal family. The typicality instruction effectively impacted the generalization of extinction; the third animal-like figure elicited lower shock expectancies in the typical relative to the atypical group. Skin conductance data mirrored these results, but did not reach significance. These findings suggest that verbal information about stimulus typicality can be a promising adjunctive to standard exposure treatments. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Stored object knowledge and the production of referring expressions: The case of color typicality

    Directory of Open Access Journals (Sweden)

    Hans eWesterbeek

    2015-07-01

    Full Text Available When speakers describe objects with atypical properties, do they include these properties in their referring expressions, even when that is not strictly required for unique referent identification? Based on previous work, we predict that speakers mention the color of a target object more often when the object is atypically colored, compared to when it is typical. Taking literature from object recognition and visual attention into account, we further hypothesize that this behavior is proportional to the degree to which a color is atypical, and whether color is a highly diagnostic feature in the referred-to object's identity. We investigate these expectations in two language production experiments, in which participants referred to target objects in visual contexts. In Experiment 1, we find a strong effect of color typicality: less typical colors for target objects predict higher proportions of referring expressions that include color. In Experiment 2 we manipulated objects with more complex shapes, for which color is less diagnostic, and we find that the color typicality effect is moderated by color diagnosticity: it is strongest for high-color-diagnostic objects (i.e., objects with a simple shape. These results suggest that the production of atypical color attributes results from a contrast with stored knowledge, an effect which is stronger when color is more central to object identification. Our findings offer evidence for models of reference production that incorporate general object knowledge, in order to be able to capture these effects of typicality on determining the content of referring expressions.

  2. Uncinate fasciculus fractional anisotropy correlates with typical use of reappraisal in women but not men.

    Science.gov (United States)

    Zuurbier, Lisette A; Nikolova, Yuliya S; Ahs, Fredrik; Hariri, Ahmad R

    2013-06-01

    Emotion regulation refers to strategies through which individuals influence their experience and expression of emotions. Two typical strategies are reappraisal, a cognitive strategy for reframing the context of an emotional experience, and suppression, a behavioral strategy for inhibiting emotional responses. Functional neuroimaging studies have revealed that regions of the prefrontal cortex modulate amygdala reactivity during both strategies, but relatively greater downregulation of the amygdala occurs during reappraisal. Moreover, these studies demonstrated that engagement of this modulatory circuitry varies as a function of gender. The uncinate fasciculus is a major structural pathway connecting regions of the anterior temporal lobe, including the amygdala to inferior frontal regions, especially the orbitofrontal cortex. The objective of the current study was to map variability in the structural integrity of the uncinate fasciculus onto individual differences in self-reported typical use of reappraisal and suppression. Diffusion tensor imaging was used in 194 young adults to derive regional fractional anisotropy values for the right and left uncinate fasciculus. All participants also completed the Emotion Regulation Questionnaire. In women but not men, self-reported typical reappraisal use was positively correlated with fractional anisotropy values in a region of the left uncinate fasciculus within the orbitofrontal cortex. In contrast, typical use of suppression was not significantly correlated with fractional anisotropy in any region of the uncinate fasciculus in either men or women. Our data suggest that in women typical reappraisal use is specifically related to the integrity of white matter pathways linking the amygdala and prefrontal cortex.

  3. Comparing Levels of Mastery Motivation in Children with Cerebral Palsy (CP) and Typically Developing Children.

    Science.gov (United States)

    Salavati, Mahyar; Vameghi, Roshanak; Hosseini, Seyed Ali; Saeedi, Ahmad; Gharib, Masoud

    2018-02-01

    The present study aimed to compare motivation in school-age children with CP and typically developing children. 229 parents of children with cerebral palsy and 212 parents of typically developing children participated in the present cross sectional study and completed demographic and DMQ18 forms. The rest of information was measured by an occupational therapist. Average age was equal to 127.12±24.56 months for children with cerebral palsy (CP) and 128.08±15.90 for typically developing children. Independent t-test used to compare two groups; and Pearson correlation coefficient by SPSS software applied to study correlation with other factors. There were differences between DMQ subscales of CP and typically developing groups in terms of all subscales ( P Manual ability classification system (r=-0.782, P<0.001) and cognitive impairment (r=-0.161, P<0.05). Children with CP had lower mastery motivation than typically developing children. Rehabilitation efforts should take to enhance motivation, so that children felt empowered to do tasks or practices.

  4. Drilling and associated drillhole measurements of the pilot hole ONK-PH11

    International Nuclear Information System (INIS)

    Karttunen, P.; Mancini, P.; Pekkanen, J.; Poellaenen, J.; Tarvainen, A.-M.; Toropainen, V.; Pere, T.

    2011-01-01

    The construction of the ONKALO access tunnel started in September 2004 at Olkiluoto. Most of the investigations related to the construction of the access tunnel aim to ensure successful excavations, reinforcement and sealing. Pilot holes are drillholes, which are core drilled along the tunnel profile. The length of the pilot holes typically varies from several tens of metres to a couple of hundred metres. The pilot holes are aimed to confirm the quality of the rock mass for tunnel construction, and in particular to identify water conductive fractured zones and to provide information that could result in modifications of the existing construction plans. The pilot hole ONK-PH11 was drilled from chainage 3922 to chainage 4053 in October 2009. The length of the hole is 131.21 metres. The aim during the drilling work was to orient core samples as much as possible. The deviation of the drillhole was measured during and after the drilling phase. Electric conductivity was measured from the collected returning water samples. Hydraulic conductivity of the fractures or fractured zones was measured by Posiva Flow Log equipment. During flow measurements also electric conductivity and temperature were measured. In flow logging test sections of 0.5 m and increments of 0.1 m were used. The water loss measurements were performed after drilling was completed by the drilling company. Logging of the core samples included the following parameters: lithology, foliation, fracturing, RQD, fractured zones, weathering and possible intersections. The rock mechanical logging was based on Q-classification. The rock strength and deformation were determined with Rock Tester -equipment. Geophysical logging and optical imaging of the pilot hole included the fieldwork of all surveys, the integration of the data as well as interpretation of the acoustic and drillhole radar data. The groundwater samples were collected from the open hole without any packers. The collected groundwater samples were

  5. An Investigation of Sensory Information, Levels of Automation, and Piloting Experience on Unmanned Aircraft Pilot Performance

    Science.gov (United States)

    2012-03-01

    Development.of. NASA - TLX .(Task.Load.Index):.Results.of.empiri- cal.and.theoretical.research ..In.P .A ..Hancock.&.N .. Meshkati.(Eds .),.Human...8 Automated Manual Level of Automation Hi gh Z oo m M an ip ul at io n Pilot Non-pilot Figure 4. Number of participants with high levels of zoom

  6. EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot)

    DEFF Research Database (Denmark)

    Maggioni, Aldo P; Dahlström, Ulf; Filippatos, Gerasimos

    2010-01-01

    The primary objective of the new ESC-HF Pilot Survey was to describe the clinical epidemiology of outpatients and inpatients with heart failure (HF) and the diagnostic/therapeutic processes applied across 12 participating European countries. This pilot study was specifically aimed at validating...

  7. EURObservational Research Programme : The Heart Failure Pilot Survey (ESC-HF Pilot)

    NARCIS (Netherlands)

    Maggioni, Aldo P.; Dahlstrom, Ulf; Filippatos, Gerasimos; Chioncel, Ovidiu; Crespo Leiro, Marisa; Drozdz, Jaroslaw; Fruhwald, Friedrich; Gullestad, Lars; Logeart, Damien; Metra, Marco; Parissis, John; Persson, Hans; Ponikowski, Piotr; Rauchhaus, Mathias; Voors, Adriaan A.; Nielsen, Olav Wendelboe; Zannad, Faiez; Tavazzi, Luigi

    2010-01-01

    The primary objective of the new ESC-HF Pilot Survey was to describe the clinical epidemiology of outpatients and inpatients with heart failure (HF) and the diagnostic/therapeutic processes applied across 12 participating European countries. This pilot study was specifically aimed at validating the

  8. Dysfunctional metacognition and drive for thinness in typical and atypical anorexia nervosa.

    Science.gov (United States)

    Davenport, Emily; Rushford, Nola; Soon, Siew; McDermott, Cressida

    2015-01-01

    Anorexia nervosa is complex and difficult to treat. In cognitive therapies the focus has been on cognitive content rather than process. Process-oriented therapies may modify the higher level cognitive processes of metacognition, reported as dysfunctional in adult anorexia nervosa. Their association with clinical features of anorexia nervosa, however, is unclear. With reclassification of anorexia nervosa by DSM-5 into typical and atypical groups, comparability of metacognition and drive for thinness across groups and relationships within groups is also unclear. Main objectives were to determine whether metacognitive factors differ across typical and atypical anorexia nervosa and a non-clinical community sample, and to explore a process model by determining whether drive for thinness is concurrently predicted by metacognitive factors. Women receiving treatment for anorexia nervosa (n = 119) and non-clinical community participants (n = 100), aged between 18 and 46 years, completed the Eating Disorders Inventory (3(rd) Edition) and Metacognitions Questionnaire (Brief Version). Body Mass Index (BMI) of 18.5 kg/m(2) differentiated between typical (n = 75) and atypical (n = 44) anorexia nervosa. Multivariate analyses of variance and regression analyses were conducted. Metacognitive profiles were similar in both typical and atypical anorexia nervosa and confirmed as more dysfunctional than in the non-clinical group. Drive for thinness was concurrently predicted in the typical patients by the metacognitive factors, positive beliefs about worry, and need to control thoughts; in the atypical patients by negative beliefs about worry and, inversely, by cognitive self-consciousness, and in the non-clinical group by cognitive self-consciousness. Despite having a healthier weight, the atypical group was as severely affected by dysfunctional metacognitions and drive for thinness as the typical group. Because metacognition concurrently predicted drive for thinness

  9. Comparison of mammographic and sonographic findings in typical and atypical medullary carcinomas of the breast

    International Nuclear Information System (INIS)

    Yilmaz, E.; Lebe, B.; Balci, P.; Sal, S.; Canda, T.

    2002-01-01

    AIM: The aim of this study was to describe the contribution of mammographic and sonographic findings to the discrimination of typical and atypical histopathologic groups of medullary carcinomas of the breast. MATERIALS AND METHODS: Imaging findings were retrospectively assessed in 33 women with medullary carcinomas (15 typical medullary carcinomas and 18 atypical medullary carcinomas) identified during pre-operative mammography. Twenty-nine of these women also had ultrasound and these findings were reviewed. RESULTS: Mammography showed a well circumscribed mass in 10 of the 15 (67%) typical medullary carcinomas and in four of the 17 (24%) atypical medullary carcinomas (P < 0.02). One small tumour in a woman with atypical medullary carcinoma was missed on mammography and was shown only on sonography. Sonographically, an irregular margin surrounding the whole mass or part of it was seen in three out of 14 (21%) patients with typical medullary carcinoma and in nine out of 15 (60%) patients with atypical medullary carcinomas (P < 0.05). Posterior acoustic shadowing was more often observed in the typical medullary carcinoma group than in atypical medullary carcinoma and the difference was found to be statistically significant (P < 0.05). None of the other mammographic and sonographic findings were sufficiently characteristic to allow for a differentiation between two groups. CONCLUSION: When typical medullary carcinomas were compared with atypical medullary carcinomas according to imaging features, they tended to be well circumscribed masses on both mammography and sonography, and a posterior acoustic shadow was not found on sonography. However, the imaging findings in these two subgroups often resembled each other and histopathology will always be required to confirm the diagnosis. Yilmaz, E. et al. (2002)

  10. Comparison of mammographic and sonographic findings in typical and atypical medullary carcinomas of the breast

    Energy Technology Data Exchange (ETDEWEB)

    Yilmaz, E.; Lebe, B.; Balci, P.; Sal, S.; Canda, T

    2002-07-01

    AIM: The aim of this study was to describe the contribution of mammographic and sonographic findings to the discrimination of typical and atypical histopathologic groups of medullary carcinomas of the breast. MATERIALS AND METHODS: Imaging findings were retrospectively assessed in 33 women with medullary carcinomas (15 typical medullary carcinomas and 18 atypical medullary carcinomas) identified during pre-operative mammography. Twenty-nine of these women also had ultrasound and these findings were reviewed. RESULTS: Mammography showed a well circumscribed mass in 10 of the 15 (67%) typical medullary carcinomas and in four of the 17 (24%) atypical medullary carcinomas (P < 0.02). One small tumour in a woman with atypical medullary carcinoma was missed on mammography and was shown only on sonography. Sonographically, an irregular margin surrounding the whole mass or part of it was seen in three out of 14 (21%) patients with typical medullary carcinoma and in nine out of 15 (60%) patients with atypical medullary carcinomas (P < 0.05). Posterior acoustic shadowing was more often observed in the typical medullary carcinoma group than in atypical medullary carcinoma and the difference was found to be statistically significant (P < 0.05). None of the other mammographic and sonographic findings were sufficiently characteristic to allow for a differentiation between two groups. CONCLUSION: When typical medullary carcinomas were compared with atypical medullary carcinomas according to imaging features, they tended to be well circumscribed masses on both mammography and sonography, and a posterior acoustic shadow was not found on sonography. However, the imaging findings in these two subgroups often resembled each other and histopathology will always be required to confirm the diagnosis. Yilmaz, E. et al. (2002)

  11. Segmental omental infarction in childhood: a typical case diagnosed by CT allowing successful conservative treatment

    International Nuclear Information System (INIS)

    Coulier, Bruno

    2006-01-01

    Segmental omental infarction (SOI) is an uncommon cause of right lower quadrant pain in children that is often misdiagnosed as appendicitis. During the last decade, imaging findings of SOI have proved to be sufficiently typical to avoid unnecessary surgery in the majority of reported adult patients. The condition has a spontaneous favourable evolution under medical treatment. In children the surgical option remains controversial. We report a typical case of SOI in a 10-year-old boy. The diagnosis was suspected by sonography, unambiguously confirmed by multidetector CT and successfully treated conservatively. This report emphasizes the use of CT in selected acute abdominal situations, peculiarly in obese children, to avoid unnecessary surgery. (orig.)

  12. Profitability of labour factor in the typical dairy farms in the world

    Directory of Open Access Journals (Sweden)

    Andrzej Parzonko

    2009-01-01

    Full Text Available The main purpose of the article was to analyse the productivity and profitability of labour factor and to present asset endowments of the typical dairy farms distinguished within IFCN (International Farm Comparison Network. Among analysed 103 typical dairy farms from 34 countries, the highest net dairy farm profit characterised large farms from USA, Australia and New Zealand. Those farms generated also significantly higher profit per working hour then the potential wages that could be earned outside the farm. The highest assets value per 100 kg of produced milk characterised European farms (especially with low production scale.

  13. Summary of typical routine maintenance activities at Tokai Reprocessing Plant. Supplement (March, 2002)

    International Nuclear Information System (INIS)

    2002-03-01

    Typical maintenance activities, such as replacement of worn out parts and cleaning of filter elements, routinely performed during steady operation are summarized. [The Summary of Typical Routine Maintenance Activities at Tokai Reprocessing Plant] (JNC TN 8450 2001-006) was already prepared in September, 2001. The purpose of this summary is to give elementary understanding on these activities to people who are responsible for explanation them to the public. At this time, the same kind of summary is prepared as a supplement of the previous one. (author)

  14. SIZING AND COSTING OPTIMISATION OF A TYPICAL WIND/PV HYBRID ELECTRICITY GENERATION SYSTEM FOR A TYPICAL RESIDENTIAL BUILDING IN URBAN ARMIDALE NSW, AUSTRALIA

    Directory of Open Access Journals (Sweden)

    Yasser Maklad

    2014-04-01

    Full Text Available This study investigates the wind and solar electricity generation availability and potentiality for residential buildings in Armidale NSW, Australia. The main purpose of this study is to design an appropriate wind-PV hybrid system to cover the electricity consumption of typical residential buildings of various occupancy rates and relevant various average electrical daily consumption. In order to do achieve that, monthly average solar irradiance monthly average wind speed historical data observed at weather station belongs to the Australian bureau of meteorology in Armidale town over a fourteen years period from 1997–2010. Simulation of solar photovoltaic panels and wind turbines were conducted to obtain the optimal hybrid system sizing and best efficient with lowest cost. Correlations between the solar and wind power data were carried out on an hourly, daily, and monthly basis. It is shown that the hybrid system can be applied for the efficient and economic utilization of wind and solar renewable energy sources.

  15. Iterative Pilot-Layer Aided Channel Estimation with Emphasis on Interleave-Division Multiple Access Systems

    Directory of Open Access Journals (Sweden)

    Schoeneich Hendrik

    2006-01-01

    Full Text Available Channel estimation schemes suitable for interleave-division multiple access (IDMA systems are presented. Training and data are superimposed. Training-based and semiblind linear channel estimators are derived and their performance is discussed and compared. Monte Carlo simulation results are presented showing that the derived channel estimators in conjunction with a superimposed pilot sequence and chip-by-chip processing are able to track fast-fading frequency-selective channels. As opposed to conventional channel estimation techniques, the BER performance even improves with increasing Doppler spread for typical system parameters. An error performance close to the case of perfect channel knowledge can be achieved with high power efficiency.

  16. The Efficacy of Using Synthetic Vision Terrain-Textured Images to Improve Pilot Situation Awareness

    Science.gov (United States)

    Uenking, Michael D.; Hughes, Monica F.

    2002-01-01

    The General Aviation Element of the Aviation Safety Program's Synthetic Vision Systems (SVS) Project is developing technology to eliminate low visibility induced General Aviation (GA) accidents. SVS displays present computer generated 3-dimensional imagery of the surrounding terrain on the Primary Flight Display (PFD) to greatly enhance pilot's situation awareness (SA), reducing or eliminating Controlled Flight into Terrain, as well as Low-Visibility Loss of Control accidents. SVS-conducted research is facilitating development of display concepts that provide the pilot with an unobstructed view of the outside terrain, regardless of weather conditions and time of day. A critical component of SVS displays is the appropriate presentation of terrain to the pilot. An experimental study is being conducted at NASA Langley Research Center (LaRC) to explore and quantify the relationship between the realism of the terrain presentation and resulting enhancements of pilot SA and performance. Composed of complementary simulation and flight test efforts, Terrain Portrayal for Head-Down Displays (TP-HDD) experiments will help researchers evaluate critical terrain portrayal concepts. The experimental effort is to provide data to enable design trades that optimize SVS applications, as well as develop requirements and recommendations to facilitate the certification process. In this part of the experiment a fixed based flight simulator was equipped with various types of Head Down flight displays, ranging from conventional round dials (typical of most GA aircraft) to glass cockpit style PFD's. The variations of the PFD included an assortment of texturing and Digital Elevation Model (DEM) resolution combinations. A test matrix of 10 terrain display configurations (in addition to the baseline displays) were evaluated by 27 pilots of various backgrounds and experience levels. Qualitative (questionnaires) and quantitative (pilot performance and physiological) data were collected during

  17. Use of Highways in the Sky and a virtual pad for landing Head Up Display symbology to enable improved helicopter pilots situation awareness and workload in degraded visual conditions.

    Science.gov (United States)

    Stanton, Neville A; Plant, Katherine L; Roberts, Aaron P; Allison, Craig K

    2017-12-15

    Flight within degraded visual conditions is a great challenge to pilots of rotary-wing craft. Environmental cues typically used to guide interpretation of speed, location and approach can become obscured, forcing the pilots to rely on data available from in-cockpit instrumentation. To ease the task of flight during degraded visual conditions, pilots require easy access to flight critical information. The current study examined the effect of 'Highways in the Sky' symbology and a conformal virtual pad for landing presented using a Head Up Display (HUD) on pilots' workload and situation awareness for both clear and degraded conditions across a series of simulated rotary-wing approach and landings. Results suggest that access to the HUD lead to significant improvements to pilots' situation awareness, especially within degraded visual conditions. Importantly, access to the HUD facilitated pilot awareness in all conditions. Results are discussed in terms of future HUD development. Practitioner Summary: This paper explores the use of a novel Heads Up Display, to facilitate rotary-wing pilots' situation awareness and workload for simulated flights in both clear and degraded visual conditions. Results suggest that access to HUD facilitated pilots' situation awareness, especially when flying in degraded conditions.

  18. Typical and atypical (cerebral palsy) development of unimanual and bimanual grasp planning

    NARCIS (Netherlands)

    Janssen, L.; Steenbergen, B.

    2011-01-01

    In the present study we tested 13 children with cerebral palsy (CP) and 24 typically developing children (7-12 years old) in a unimanual and bimanual motor planning task. We focused on two research questions: (1) How does motor planning develop in children with and without CP? and (2) Is motor

  19. Social-Emotional Inhibition of Return in Children with Autism Spectrum Disorder versus Typical Development

    Science.gov (United States)

    Antezana, Ligia; Mosner, Maya G.; Troiani, Vanessa; Yerys, Benjamin E.

    2016-01-01

    In typical development there is a bias to orient visual attention to social information. Children with ASD do not reliably demonstrate this bias, and the role of attention orienting has not been well studied. We examined attention orienting via the inhibition of return (IOR) mechanism in a spatial cueing task using social-emotional cues; we…

  20. Bridging the Gaps in the Study of Typical and Atypical Cognitive Development: A Commentary

    Science.gov (United States)

    Graham, Susan A.; Madigan, Sheri

    2016-01-01

    The articles in this special issue of the "Journal of Cognition and Development" examine the cognitive development of children who are following typical and atypical developmental pathways. The articles offer a mixture of theory-based considerations, reviews of the literature, and new empirical data addressing fundamental aspects of…

  1. Parenting a Child with ASD: Comparison of Parenting Style between ASD, Anxiety, and Typical Development

    Science.gov (United States)

    Ventola, Pamela; Lei, Jiedi; Paisley, Courtney; Lebowitz, Eli; Silverman, Wendy

    2017-01-01

    Parenting children with ASD has a complex history. Given parents' increasingly pivotal role in children's treatment, it is critical to consider parental style and behaviours. This study (1) compares parenting style of parents of children with ASD, parents of children with anxiety disorders, and parents of typically developing (TD) children and (2)…

  2. Guiding role of typical cases in clinical training for ophthalmology professional degree graduate students

    Directory of Open Access Journals (Sweden)

    Zhe Wang

    2014-05-01

    Full Text Available With the change of the concept of graduate enrollment, the recruiting proportion of clinical medicine professional degree graduate students is more and more, and the training of professional degree graduate students is increasingly focusing on practical. In our experience in clinical training for ophthalmology professional degree graduate students, increasing the ward clinical practice time is important. For particular emphasis on the guiding role of the typical cases, each professional group combined their professional characteristics of the typical cases to instruct the graduate students, training their clinical diagnosis and treatment ability, training their microsurgical techniques. From clinical medical writing, record summary, literature review, professional degree graduate students could expand their knowledge structure, practice their thesis writing ability. Based on the typical cases, expansion of knowledge coverage, they could improve the ability of diagnosis and treatment for special disease cases. In this rigorous training system, professional degree graduate students can learn by analogy, and focus on typical cases to get the most intuitive panoramic understanding of the diseases, with a minimum of time to master the most clinical knowledge, to enrich clinical experience, and to lay the foundation for future work in the assessment.

  3. Swedish Upper Secondary Students' Perspectives on the Typical Mathematics Lesson

    Science.gov (United States)

    Andrews, Paul; Larson, Niclas

    2017-01-01

    This paper presents a group interview study of Swedish upper secondary students' perspectives on the typical mathematics lesson. Students, from four demographically different schools, constructed a collective synthesis of their many years' experience of mathematics classrooms. Transcriptions were subjected to a constant comparison analysis, which…

  4. Contribution of milk production to global greenhouse gas emissions. An estimation based on typical farms.

    Science.gov (United States)

    Hagemann, Martin; Ndambi, Asaah; Hemme, Torsten; Latacz-Lohmann, Uwe

    2012-02-01

    Studies on the contribution of milk production to global greenhouse gas (GHG) emissions are rare (FAO 2010) and often based on crude data which do not appropriately reflect the heterogeneity of farming systems. This article estimates GHG emissions from milk production in different dairy regions of the world based on a harmonised farm data and assesses the contribution of milk production to global GHG emissions. The methodology comprises three elements: (1) the International Farm Comparison Network (IFCN) concept of typical farms and the related globally standardised dairy model farms representing 45 dairy regions in 38 countries; (2) a partial life cycle assessment model for estimating GHG emissions of the typical dairy farms; and (3) standard regression analysis to estimate GHG emissions from milk production in countries for which no typical farms are available in the IFCN database. Across the 117 typical farms in the 38 countries analysed, the average emission rate is 1.50 kg CO(2) equivalents (CO(2)-eq.)/kg milk. The contribution of milk production to the global anthropogenic emissions is estimated at 1.3 Gt CO(2)-eq./year, accounting for 2.65% of total global anthropogenic emissions (49 Gt; IPCC, Synthesis Report for Policy Maker, Valencia, Spain, 2007). We emphasise that our estimates of the contribution of milk production to global GHG emissions are subject to uncertainty. Part of the uncertainty stems from the choice of the appropriate methods for estimating emissions at the level of the individual animal.

  5. Spontaneous Lexical Alignment in Children with an Autistic Spectrum Disorder and Their Typically Developing Peers

    Science.gov (United States)

    Branigan, Holly P.; Tosi, Alessia; Gillespie-Smith, Karri

    2016-01-01

    It is well established that adults converge on common referring expressions in dialogue, and that such lexical alignment is important for successful and rewarding communication. The authors show that children with an autistic spectrum disorder (ASD) and chronological- and verbal-age-matched typically developing (TD) children also show spontaneous…

  6. Computed tomography derived fractional flow reserve testing in stable patients with typical angina pectoris

    DEFF Research Database (Denmark)

    Møller Jensen, Jesper; Erik Bøtker, Hans; Norling Mathiassen, Ole

    2017-01-01

    Aims: To assess the use of downstream coronary angiography (ICA) and short-term safety of frontline coronary CT angiography (CTA) with selective CT-derived fractional flow reserve (FFRCT) testing in stable patients with typical angina pectoris. Methods and results: Between 1 January 2016 and 30 J...... of safe cancellation of planned ICAs....

  7. Recall Memory in Children with Down Syndrome and Typically Developing Peers Matched on Developmental Age

    Science.gov (United States)

    Milojevich, H.; Lukowski, A.

    2016-01-01

    Background: Whereas research has indicated that children with Down syndrome (DS) imitate demonstrated actions over short delays, it is presently unknown whether children with DS recall information over lengthy delays at levels comparable with typically developing (TD) children matched on developmental age. Method: In the present research, 10…

  8. Bridge Building and Other Possible Metaphors for Patching over Discrepancies between Typical and Atypical Development

    Science.gov (United States)

    Chandler, Michael

    2016-01-01

    The next several pages are intended as a "Commentary" on the six target articles bundled together as a Special Issue of the "Journal of Cognition and Development"--literature reviews and research reports all intended to "build bridges" between the study of cognitive development in typical and atypical populations.

  9. Severity of Emotional and Behavioral Problems among Poor and Typical Readers.

    Science.gov (United States)

    Arnold, Elizabeth Mayfield; Goldston, David B.; Walsh, Adam K.; Reboussin, Beth A.; Daniel, Stephanie Sergent; Hickman, Enith; Wood, Frank B.

    2005-01-01

    The purpose of this study was to examine the severity of behavioral and emotional problems among adolescents with poor and typical single word reading ability (N = 188) recruited from public schools and followed for a median of 2.4 years. Youth and parents were repeatedly assessed to obtain information regarding the severity and course of symptoms…

  10. Basic Auditory Processing Skills and Phonological Awareness in Low-IQ Readers and Typically Developing Controls

    Science.gov (United States)

    Kuppen, Sarah; Huss, Martina; Fosker, Tim; Fegan, Natasha; Goswami, Usha

    2011-01-01

    We explore the relationships between basic auditory processing, phonological awareness, vocabulary, and word reading in a sample of 95 children, 55 typically developing children, and 40 children with low IQ. All children received nonspeech auditory processing tasks, phonological processing and literacy measures, and a receptive vocabulary task.…

  11. Adolescent Risk Behaviors: Studying Typical and Atypical Individuals via Multidimensional Scaling Profile Analysis

    Science.gov (United States)

    Dong, Yang; Ding, Cody

    2012-01-01

    Within the framework of problem behavior theory, the purpose of this study was to examine risk behavior profiles of typical and atypical adolescents and the differential outcomes of well-beings for these individuals in the United States. Based on the data from the survey of Health Behavior of School-Aged Children by World Health Organization,…

  12. Of tissue blocks and higher anatomy: A typical day in the life of a ...

    African Journals Online (AJOL)

    succumb, sleep the only respite life has gifted me. Tomorrow shall be yet another day…yet another opportunity to learn. It starts as a typical Monday... all Mondays do - the frantic typing that fills the air, reminiscent of a typing press. Be it a literature review or the presentation for the afternoon class, the innocent bystander may ...

  13. Comparison of Endoscopic and Histological Findings between Typical and Atypical Celiac Disease in Children.

    Science.gov (United States)

    Semwal, Pooja; Gupta, Raj Kumar; Sharma, Rahul; Garg, Kapil

    2018-04-01

    Celiac disease is a common non-communicable disease with varied presentations. Purpose of this study was to find the duodeno-endoscopic features in celiac disease and to compare duodeno-endoscopic and histological findings between typical and atypical celiac disease in children. Hospital based observational study was conducted at Sir Padampat Mother and Child Health Institute, Jaipur from June 2015 to May 2016. Patients were selected and divided in two groups- typical and atypical celiac disease based upon the presenting symptoms. Upper gastrointestinal endoscopy and duodenal biopsy was performed for serology positive patients. Results were analysed using appropriate statistical test of significance. Out of 101 enrolled patients, 47.5% were male. Age ranged from 1 to 18 years. Study showed that 54.5% were typical and 45.5% were atypical. Patients presenting with atypical symptoms were predominantly of older age group. On endoscopy, scalloping, mosaic pattern, reduced fold height and absent fold height; and in histology, advanced Marsh stage were significantly higher in the typical group. Awareness of atypical presentations as well as duodeno-endoscopic features may have considerable practical importance for the diagnosis of celiac disease in children. Scalloping, mosaic pattern, reduced fold height and nodularity are main endoscopic markers of celiac disease in children. Endoscopic markers of duodenal mucosa may be important in early diagnosis of celiac disease, in children subjected to endoscopy for atypical presentations or indication other than suspected celiac disease.

  14. Textese and use of texting by children with typical language development and Specific Language Impairment

    NARCIS (Netherlands)

    Blom, E.; van Dijk, C.; Vasić, N.; van Witteloostuijn, M.; Avrutin, S.

    The purpose of this study was to investigate texting and textese, which is the special register used for sending brief text messages, across children with typical development (TD) and children with Specific Language Impairment (SLI). Using elicitation techniques, texting and spoken language messages

  15. Typical Plan : The Architecture of Labor and the Space of Production

    NARCIS (Netherlands)

    Marullo, F.

    2014-01-01

    In a short essay dealing with the repetitive homogeneity of the Manhattan’s office layouts, Rem Koolhaas defined the term Typical Plan as one of the purest American architectural archetypes. A plan stripped of all its qualities and reduced to a calculated relation between discreet standardised

  16. The Readiness of Typical Student in Communication By Using Sign Language in Hearing Impairment Integration Programe

    Directory of Open Access Journals (Sweden)

    Mohd Hanafi Mohd Yasin

    2018-05-01

    Full Text Available This research is regarding the readiness of typical student in communication by using sign language in Hearing Impairment Integration Programme. There were 60 typical students from a Special Education Integration Programme of secondary school in Malacca were chosen as research respondents. The instrument of the research was a set of questionnaire which consisted of four parts, namely Student’s demography (Part A, Student’s knowledge (Part B, Student’s ability to communicate (Part C and Student’s interest to communicate (Part D. The questionnaire was adapted from the research of Asnul Dahar and Rabiah's 'The Readiness of Students in Following Vocational Subjects at Jerantut District, Rural Secondary School in Pahang'.  Descriptive analysis was used to analysis the data. Mean score was used to determine the level of respondents' perception of each question. The findings showed a positive relationship between typical students towards communication medium by using sign language. Typical students were seen to be interested in communicating using sign language and were willing to attend the Sign Language class if offered.

  17. Comparison with the Typical College Student Predicts Graduation When Identity Is Uncertain

    Science.gov (United States)

    Lane, David J.

    2017-01-01

    This study investigated the effect of personal identity and social comparison on college graduation. First-year college students completed an online survey measuring exploration and commitment to personal identity and perceptions of the prototypical student. Those who perceived the typical student as favorable but dissimilar to themselves had the…

  18. Ex-plant consequence assessment for NUREG-1150: models, typical results, uncertainties

    International Nuclear Information System (INIS)

    Sprung, J.L.

    1988-01-01

    The assessment of ex-plant consequences for NUREG-1150 source terms was performed using the MELCOR Accident Consequence Code System (MACCS). This paper briefly discusses the following elements of MACCS consequence calculations: input data, phenomena modeled, computational framework, typical results, controlling phenomena, and uncertainties. Wherever possible, NUREG-1150 results will be used to illustrate the discussion. 28 references

  19. The Relationship between Intolerance of Uncertainty, Sensory Sensitivities, and Anxiety in Autistic and Typically Developing Children

    Science.gov (United States)

    Neil, Louise; Olsson, Nora Choque; Pellicano, Elizabeth

    2016-01-01

    Guided by a recent theory that proposes fundamental differences in how autistic individuals deal with uncertainty, we investigated the extent to which the cognitive construct "intolerance of uncertainty" and anxiety were related to parental reports of sensory sensitivities in 64 autistic and 85 typically developing children aged…

  20. Word Problem Solving of Students with Autistic Spectrum Disorders and Students with Typical Development

    Science.gov (United States)

    Bae, Young Seh

    2013-01-01

    Mathematical Word Problem Solving of Students with Autistic Spectrum Disorders and Students with Typical Development Young Seh Bae This study investigated mathematical word problem solving and the factors associated with the solution paths adopted by two groups of participants (N=40), students with autism spectrum disorders (ASDs) and typically…