Reproductibilité des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie.

Science.gov (United States)

Ben Abdelkrim, Soumaya; Rammeh, Soumaya; Trabelsi, Amel; Ben Yacoub-Abid, Lilia; Ben Sorba, Nabil; Jaïdane, Lilia; Mokni, Moncef

2012-12-01

RéSUMé: OBJECTIF : Déterminer les taux d'accord et la reproductibilité intra et inter-observateurs des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie. MATéRIEL ET MéTHODES : Cent deux cas de tumeurs urothéliales papillaires de stade pTa/pT1 ont été étudiés. Deux pathologistes ont revu les lames et ont établi le grade tumoral selon les deux classifications OMS 1973 et OMS 2004. En cas de désaccord, les deux évaluateurs ont procédé à une lecture commune au microscope en double tête afin d'aboutir à un grade consensuel selon les deux classifications. La variabilité intra-observateur a été étudiée chez l'un des deux évaluateurs qui a procédé à la relecture des lames un mois après sa première lecture. Les taux d'accord entre les deux pathologistes pour chaque catégorie de grade ont été déterminés et la reproductibilité des deux classifications a été évaluée à l'aide du coefficient kappa. Une valeur de 0 à 0,2 était interprétée comme un désaccord absolu, de 0,21 à 0,4, un accord faible, de 0,41 à 0,6, un accord modéré, de 0,61 à 0,8, un accord considérable, et de 0,8 à 1, un accord absolu. RéSULTATS : Selon la classification OMS 1973, les proportions des grades G1, G2 et G3 étaient respectivement de 40,2 %, 50 % et 9,8 %. Selon la classification OMS 2004, les proportions respectives des tumeurs de faible potentiel de malignité, des carcinomes de bas grade et des carcinomes de haut grade de malignité étaient de 23,5 %, 60,8 % et 15,7 %. La reproductibilité intra-observateur était excellente pour les deux classifications (accord absolu). Les taux d'accord entre les deux pathologistes étaient meilleurs pour la classification OMS 2004 (kappa = 0,7) que pour la classification OMS 1973 (kappa = 0,51). La reproductibilité entre observateurs de la classification OMS 2004 est supérieure à celle de 1973. La reproductibilité intra-observateur est excellente pour les deux

Detection of fission fragments by secondary emission; Detection des fragments de fission par emission secondaire

Energy Technology Data Exchange (ETDEWEB)

Audias, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1965-07-01

This fission fragment detecting apparatus is based on the principle that fragments traversing a thin foil will cause emission of secondary electrons. These electrons are then accelerated (10 kV) and directly detected by means of a plastic scintillator and associated photomultiplier. Some of the advantages of such a detector are, its rapidity, its discriminating power between alpha particles and fission fragments, its small energy loss in detecting the fragments and the relatively great amount of fissionable material which it can contain. This paper is subdivided as follows: a) theoretical considerations b) constructional details of apparatus and some experimental details and c) a study of the secondary emission effect itself. (author) [French] Le detecteur de fragments de fission que nous avons realise est base sur le principe de l'emission secondaire produite par les fragments de fission traversant une feuille mince: les electrons secondaires emis sont acceleres a des tensions telles (de l'ordre de 10 kV), qu'ils soient directement detectables par un scintillateur plastique associe a un photomultiplicateur. L'interet d'un tel detecteur reside: dans sa rapidite, sa tres bonne discrimination alpha, fission, la possibilite de detecter les fragments de fission avec une perte d'energie pouvant rester relativement faible, et la possibilite d'introduire des quantites de matiere fissile plus importantes que dans les autres types de detecteurs. Ce travail comporte: -) un apercu bibliographique de la theorie du phenomene, -) realisation et mise au point du detecteur avec etude experimentale de quelques parametres intervenant dans l'emission secondaire, -) etude de l'emission secondaire (sur la face d'emergence des fragments de fission) en fonction de l'energie du fragment et en fonction de l'epaisseur de matiere traversee avant emission secondaire, et -) une etude comparative de l'emission secondaire sur la face d'incidence et sur la face d'emergence des fragments de

Case series

African Journals Online (AJOL)

ebutamanya

4 sept. 2015 ... rapport avec la stase urinaire (infection urinaire, lithiase vésicale). [12] des complications plus rares ont été rapportées telles que la survenue d'une tumeur vésicale intraherniaire [13] ou une insuffisance rénale secondaire à la compression du trigone [5]. En cas de diagnostic pré-opératoire le traitement ...

Les tumeurs desmoides de la paroi thoracique : à propos de 12 cas Dermoid tumors of the thoracic wall: about 12 cases

Directory of Open Access Journals (Sweden)

Abdellatif Benosman

2009-11-01

Full Text Available Les tumeurs desmoides sont des tumeurs rares des tissus mous qui peuvent être très agressives localement. A travers l’expérience de notre service, nous analyserons les résultats du traitement chirurgical de ces tumeurs. De 1980 à 2008, 12 patients ont été opérés pour tumeur desmoide de la paroi thoracique. Le diagnostic a été suspecté sur la base des signes cliniques et radiologiques. Aucun patient n’avait un syndrome de Gardner. L’abord chirurgical a été souvent électif à l’aplomb de la tumeur. La résection a été complète dans 11 cas. La confirmation diagnostique a été apportée par l’étude histologique de la pièce opératoire. La durée du suivi post opératoire variait entre 24 et 180 mois. Une patiente était décédée par insuffisance cardiaque et rénale. 7 cas avaient récidivé, et qui ont été traités par simple résection complète dans 5 cas, dont un avait nécessité une greffe myocutanée ; par ailleurs, deux cas ont été traités par résection incomplète associée à une radiothérapie adjuvante. La chirurgie des tumeurs desmoides de la paroi thoracique doit être aussi large que possible pour diminuer le risque de récidive.

Le dermatofibrosarcome de Darier et Ferrand, une tumeur cutanée particulière: à propos de 32 cas et revue de la littérature

Science.gov (United States)

Elamrani, Driss; Droussi, Hatim; Boukind, Samira; Elatiqi, Keltoum; Dlimi, Meriem; Benchamkha, Yassine; Ettalbi, Saloua

2014-01-01

Le dermatofibrosarcome (DFS) est une tumeur fibreuse de la peau, de croissance lente, à très haut risque de récidive locale, mais à potentiel métastatique faible. A partir d'une étude rétrospective étalée sur une période de 5 ans (décembre 2008 - décembre 2013), nous avons analysé les caractéristiques épidémiologiques et cliniques, le délai de diagnostic, le type de thérapeutique et le devenir de 32 patients présentant des tumeurs de Darier et Ferrand histologiquement prouvées. Parmi les 32 patients, 10 se sont présentés initialement au service pour une récidive tumorale. Une discrète prédominance masculine a été notée. Les DFS touchent préférentiellement l'adulte jeune. Le délai diagnostique observé est en moyenne de 4 ans. Le tronc est la localisation préférentielle (60%), suivi par les extrémités proximales (30%). Les 32 patients ont été traités par exérèse chirurgicale avec une marge de 5cm en surface, emportant en profondeur une barrière anatomique saine. La couverture de la perte de substance (PDS) a été réalisée après confirmation anatomopathologique du caractère carcinologique de l'exérèse, et a fait appel à différents moyens allant de la greffe cutanée aux lambeaux musculo –cutanés libres. L’évolution a été marquée par la survenue d'une récidive tumorale chez 8 patients (3 cas parmi les tumeurs vues en première intention et 5 cas parmi les tumeurs vues en récidive) et les résultats ont été jugés satisfaisants sur le plan esthétique et fonctionnel. Le DFS de Darier et Ferrand est une tumeur dont le pronostic et le risque évolutif sont principalement liés au délai diagnostic et la qualité de la première exérèse. Le diagnostic tardif, rend difficile la chirurgie d'exérèse et de reconstruction Les possibilités de guérison en cas de chirurgie primaire bien conduite sont significativement supérieures à celles d'une chirurgie de rattrapage. L'amélioration du pronostic passe par

An orbital masquerade syndrome: a case report | Omoti | West ...

African Journals Online (AJOL)

Ce rapport présent le cas d'une femme âgée de 20 ans qui s'est présentée avec des symptômes de la panophtalmie du côté droite avec une cellulite orbitaire secondaire qui essaie de se faire passer pour une tumeur orbitaire. Ce phénomène produit une difficulté diagnostique pour plusieurs ophtalmogistes. Echographie ...

Compression medullaire lente secondaire a un lymphome de Burkitt ...

African Journals Online (AJOL)

faciale à la fin du 1er mois et une récupération neurologique au bout d'un an. La localisation secondaire intra rachidienne d'un LB bien que rare doit être présente à l'esprit surtout en face d'une compression médullaire lente survenue dans un ...

Intérêt pronostique de l'infiltration du chorion dans les tumeurs ...

African Journals Online (AJOL)

W. Zakhama

Disponible sur Internet le 27 octobre 2016. MOTS CLÉS tumeur vésicale; survie; .... ont eu une récidive précoce (inférieur à 6 mois). La récidive n'était ... recherche de nouvelles sous classification dans le but de trouver de nouveaux facteurs ...

Association grossesse et pseudomyxome péritonéal secondaire à ...

African Journals Online (AJOL)

Une chirurgie radicale a été faite avec à l'étude histologique définitive: une tumeur ovarienne mucineuse borderline avec tératome mature et pseudomyxome péritonéal. A travers ce cas rare et à la lumière d'une revue de la littérature nous insistons sur les caractéristiques épidémiologiques diagnostiques, thérapeutiques et ...

Inhibition of Pseudomonas aeruginosa virulence: characterization of the AprA-AprI interface and species selectivity.

Science.gov (United States)

Bardoel, Bart W; van Kessel, Kok P M; van Strijp, Jos A G; Milder, Fin J

2012-01-20

Pseudomonas aeruginosa secretes the virulence factor alkaline protease (AprA) to enhance its survival. AprA cleaves one of the key microbial recognition molecules, monomeric flagellin, and thereby diminishes Toll-like receptor 5 activation. In addition, AprA degrades host proteins such as complement proteins and cytokines. P. aeruginosa encodes a highly potent inhibitor of alkaline protease (AprI) that is solely located in the periplasm where it is presumed to protect periplasmic proteins against secreted AprA. We set out to study the enzyme-inhibitor interactions in more detail in order to provide a basis for future drug development. Structural and mutational studies reveal that the conserved N-terminal residues of AprI occupy the protease active site and are essential for inhibitory activity. We constructed peptides mimicking the N-terminus of AprI; however, these were incapable of inhibiting AprA-mediated flagellin cleavage. Furthermore, we expressed and purified AprI of P. aeruginosa and the homologous (37% sequence identity) AprI of Pseudomonas syringae, which remarkably show species specificity for their cognate protease. Exchange of the first five N-terminal residues between AprI of P. syringae and P. aeruginosa did not affect the observed specificity, whereas exchange of only six residues located at the AprI surface that contacts the protease did abolish specificity. These findings are elementary steps toward the design of molecules derived from the natural inhibitor of the virulence factor AprA and their use in therapeutic applications in Pseudomonas and other Gram-negative infections. Copyright © 2011 Elsevier Ltd. All rights reserved.

Intérêt pronostique de l’infiltration du chorion dans les tumeurs vésicales pT1

Directory of Open Access Journals (Sweden)

W. Zakhama

2016-12-01

Conclusion: Le classement des ces tumeurs en fonction de l’importance d’envahissement du chorion et de l’infiltration de la musculaire muqueuse a prouvé son efficacité à travers les taux de récidive et de progression tumorale chez nos malades.

Effets des electrons secondaires sur l'ADN

Science.gov (United States)

Boudaiffa, Badia

Les interactions des electrons de basse energie (EBE) representent un element important en sciences des radiations, particulierement, les sequences se produisant immediatement apres l'interaction de la radiation ionisante avec le milieu biologique. Il est bien connu que lorsque ces radiations deposent leur energie dans la cellule, elles produisent un grand nombre d'electrons secondaires (4 x 104/MeV), qui sont crees le long de la trace avec des energies cinetiques initiales bien inferieures a 20 eV. Cependant, il n'y a jamais eu de mesures directes demontrant l'interaction de ces electrons de tres basse energie avec l'ADN, du principalement aux difficultes experimentales imposees par la complexite du milieu biologique. Dans notre laboratoire, les dernieres annees ont ete consacrees a l'etude des phenomenes fondamentaux induits par impact des EBE sur differentes molecules simples (e.g., N2, CO, O2, H2O, NO, C2H 4, C6H6, C2H12) et quelques molecules complexes dans leur phase solide. D'autres travaux effectues recemment sur des bases de l'ADN et des oligonucleotides ont montre que les EBE produisent des bris moleculaires sur les biomolecules. Ces travaux nous ont permis d'elaborer des techniques pour mettre en evidence et comprendre les interactions fondamentales des EBE avec des molecules d'interet biologique, afin d'atteindre notre objectif majeur d'etudier l'effet direct de ces particules sur la molecule d'ADN. Les techniques de sciences des surfaces developpees et utilisees dans les etudes precitees peuvent etre etendues et combinees avec des methodes classiques de biologie pour etudier les dommages de l'ADN induits par l'impact des EBE. Nos experiences ont montre l'efficacite des electrons de 3--20 eV a induire des coupures simple et double brins dans l'ADN. Pour des energies inferieures a 15 eV, ces coupures sont induites par la localisation temporaire d'un electron sur une unite moleculaire de l'ADN, ce qui engendre la formation d'un ion negatif transitoire

Effet de la mise en culture des forêts secondaires sur les ...

African Journals Online (AJOL)

L'impact de la mise en culture des forêts sur les peuplements de macroinvertébrés du sol a été étudié en moyenne Côte d'Ivoire avec pour objectif d'identifier les plus sensibles à la perturbation des forêts. Les macroinvertébrés du sol de parcelles de forêt secondaire et de cultures vivrières ont été échantillonnés en utilisant ...

Respirators: APR Issuer Self Study 33461

Energy Technology Data Exchange (ETDEWEB)

Chochoms, Michael [Los Alamos National Laboratory

2016-07-13

Respirators: APR Issuer Self-Study (course 33461) is designed to introduce and familiarize employees selected as air-purifying respirator (APR) issuers at Los Alamos National Laboratory (LANL) with the responsibilities, limitations, procedures, and resources for issuing APRs at LANL. The goal is to enable these issuers to consistently provide proper, functioning APRs to authorized users

Apport de la biopsie radioguidée dans le diagnostic histopathologique des tumeurs de l'enfant: expérience de l'Hôpital d'Enfant de Rabat

Science.gov (United States)

El Ochi, Mohamed Réda; Bellarbi, Salma; Rouas, Lamiae; Lamalmi, Najat; Malihy, Abderrahmane; Alhamany, Zaitouna; Cherradi, Nadia

2015-01-01

La biopsie radioguidée constitue une alternative à la biopsie chirurgicale invasive et à la cytologie pour le diagnostic des tumeurs pédiatriques. L'intérêt de notre étude est d’évaluer la valeur diagnostique des biopsies radioguidées examinées au laboratoire d'anatomopathologie de l'hôpital d'Enfants de Rabat (HER). L’étude a porté sur 78 biopsies radioguidées recueillies dans notre laboratoire entre janvier 2008 et décembre 2011. l’âge moyen des patients était de 5 ans et 10 mois avec une prédominance masculine (65,4%). La tumeur était abdominale dans 80% des cas, thoracique dans 15% cas, thoracique et abdominale dans 2,5% et sacrée dans 1,2%. Les biopsies étaient écho-guidées dans 90% des cas et scannoguidées dans 10% des cas. Le diagnostic histopathologique était posé dans 89% des cas. L'immuno-histochimie a été indiquée dans 35% des cas. Les diagnostics les plus fréquents étaient: tumeurs neuroblastiques (42 cas), lymphomes non hodgkiniens (10 cas), rhabdomyosarcomes (6 cas), autres (sarcome d'Ewing, néphroblastomes, tumeur myofibroblastique inflammatoire, maladies de Hodgkin, leucémie aiguë, hépatoblastome et ostéosarcome). Dans notre série, la biopsie radioguidée a permis un diagnostic histopathologique certain dans 89% des cas. Elle nécessite une étroite collaboration entre clinicien, radiologue et anatomopathologiste pour discuter son indication, afin de diminuer le nombre de biopsies peu ou non représentatives. PMID:26587165

Diagnostic des lésions étiologiques de l'infertilité secondaire à ...

African Journals Online (AJOL)

SARAH

31 août 2013 ... Objectif : L'infertilité est une préoccupation du couple et de la famille en milieu africain. Le but de cette étude est d'améliorer la prise en charge des femmes présentant une infertilité secondaire au Bénin. Méthodologie et résultats : Il s'est agi d'une étude descriptive de type transversal. Elle a porté sur 110 ...

Traitements didactiques preventifs d'un type de conceptions erronees en sciences physiques chez des eleves du secondaire

Science.gov (United States)

Blondin, Andre

hypotheses avec la cohorte suivante d'eleves chez qui se repetaient les memes conditions d'apprentissage. Nous avons utilise le design de recherche "posttest only" de Campbell et Stanley. En mai, apres le moment prevu dans la planification du programme pour donner le probleme aux eleves, nous avons suggere deux facons differentes de reviser la solution de ce probleme. Les eleves du premier groupe experimental ont revise sans que soit activee la connaissance anterieure apprehendee de la rotation de la Terre. Les eleves du deuxieme groupe experimental ont ete confrontes, par des questions et une simulation, au fait que la rotation de la Terre n'est pas une connaissance pertinente pour resoudre le probleme. Les groupes temoins et les groupes experimentaux ont ete choisis au hasard dans le bassin des ecoles secondaires de la commission scolaire. (Abstract shortened by UMI.)

La m?taplasie osteoide de l'endom?tre apr?s une grossesse ? terme: ? propos d'un cas rare

OpenAIRE

Jayi, Sofia; Bouguern, Hakima; Fatemi, Hind; Chaara, Hikmat; Laamarti, Afaf; Melhouf, Aabdelilah

2013-01-01

La m?taplasie ost?o?de de l'endom?tre (MOE) est une entit? rare correspondant ? la pr?sence de tissu osseux dans l'endom?tre, elle est le plus souvent diagnostiqu?e dans un contexte d'infertilit? secondaire faisant suite ? une grossesse interrompue. M?me si plusieurs facteurs de risque sont r?pertori?s, sa physiopathologie reste mal connue et sa traduction clinique est tr?s variable. Nous rapportons un cas de MOE apparu suite ? un curetage pour r?tention placentaire en post-partum. Le diagnos...

Design Characteristics of Soft Control for APR+

Energy Technology Data Exchange (ETDEWEB)

Kim, Yongsoo; Sung, Chanho; Jung, Yeonsub [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

In the global nuclear industry, the design requirements have been largely divided into the US and the European ones. The APR+ design, based on the proven APR1400 design, was developed to fully comply with the US regulatory and utility requirements. It was also developed to improve the technical competitiveness and enlarge the export market share through design uniqueness and the improvement of safety. The robust design of safety and its validation were requested Post-Fukushima accident. So MMIS design and validation for reinforcing safety were accomplished in APR+ development project. In this paper, the design characteristics of soft control for APR+ are presented to enhance the safety of MMIS design. In this paper, the major design characteristics of soft control for APR+ were introduced to increase the safety of MMIS design. In addition to the design characteristics of soft control described above, the following should be investigated closely for APR+ to get into the global nuclear industry.

Design Characteristics of Soft Control for APR+

International Nuclear Information System (INIS)

Kim, Yongsoo; Sung, Chanho; Jung, Yeonsub

2016-01-01

In the global nuclear industry, the design requirements have been largely divided into the US and the European ones. The APR+ design, based on the proven APR1400 design, was developed to fully comply with the US regulatory and utility requirements. It was also developed to improve the technical competitiveness and enlarge the export market share through design uniqueness and the improvement of safety. The robust design of safety and its validation were requested Post-Fukushima accident. So MMIS design and validation for reinforcing safety were accomplished in APR+ development project. In this paper, the design characteristics of soft control for APR+ are presented to enhance the safety of MMIS design. In this paper, the major design characteristics of soft control for APR+ were introduced to increase the safety of MMIS design. In addition to the design characteristics of soft control described above, the following should be investigated closely for APR+ to get into the global nuclear industry

Etude de pratiques d'enseignement relatives a la modelisation en sciences et technologies avec des enseignants du secondaire

Science.gov (United States)

Aurousseau, Emmanuelle

Les modeles sont des outils amplement utilises en sciences et technologies (S&T) afin de representer et d’expliquer un phenomene difficilement accessible, voire abstrait. La demarche de modelisation est presentee de maniere explicite dans le programme de formation de l’ecole quebecoise (PFEQ), notamment au 2eme cycle du secondaire (Quebec. Ministere de l'Education du Loisir et du Sport, 2007a). Elle fait ainsi partie des sept demarches auxquelles eleves et enseignants sont censes recourir. Cependant, de nombreuses recherches mettent en avant la difficulte des enseignants a structurer leurs pratiques d’enseignement autour des modeles et de la demarche de modelisation qui sont pourtant reconnus comme indispensables. En effet, les modeles favorisent la conciliation des champs concrets et abstraits entre lesquels le scientifique, meme en herbe, effectue des allers-retours afin de concilier le champ experimental de reference qu’il manipule et observe au champ theorique relie qu’il construit. L’objectif de cette recherche est donc de comprendre comment les modeles et la demarche de modelisation contribuent a faciliter l’articulation du concret et de l’abstrait dans l’enseignement des sciences et des technologies (S&T) au 2eme cycle du secondaire. Pour repondre a cette question, nous avons travaille avec les enseignants dans une perspective collaborative lors de groupes focalises et d’observation en classe. Ces dispositifs ont permis d’examiner les pratiques d’enseignement que quatre enseignants mettent en oeuvre en utilisant des modeles et des demarches de modelisation. L’analyse des pratiques d’enseignement et des ajustements que les enseignants envisagent dans leur pratique nous permet de degager des connaissances a la fois pour la recherche et pour la pratique des enseignants, au regard de l’utilisation des modeles et de la demarche de modelisation en S&T au secondaire.

sommaire N°13

African Journals Online (AJOL)

Le traitement de cette tumeur bénigne et agressive n'est pas bien codifié. il fait recours essentiellement à la chi- rurgie. Nous rapportons une observation d'un FNP avec exten- sion au niveau de la fosse infratemporale traité par chi- rurgie après embolisation et discutons les autres moyens thérapeutiques. oBSERVAtIoN.

Case series

African Journals Online (AJOL)

ebutamanya

9 juin 2008 ... longtemps débattue, après avoir proposé initialement une origine musculaire striée les études récentes sont en faveur d'une origine neurogène schwannienne confirmées par une étude immunohistochimique. Le traitement de la tumeur à cellules granuleuses est un traitement chirurgical, il permet un ...

Les Mélanomes Malins Nasosinusiens | Hariga | Journal Tunisien d ...

African Journals Online (AJOL)

La symptomatologie clinique est dominée par l\\'obstruction nasale et l\\'épistaxis. Le diagnostic est histologique après biopsie de la tumeur. Le traitement chirurgical est suivi d\\'une radiothérapie externe dans les deux cas. L\\'évolution est marquée par une récidive tumorale dans un cas. Primary mucosal melanoma of the ...

Carcinome épidermoïde Primitif de la Prostate: A propos d’un cas et revue de la littérature

Directory of Open Access Journals (Sweden)

A. Bahloul

2016-12-01

Full Text Available Le cancer de la prostate est la tumeur maligne la plus fréquente chez l’homme. La grande majorité des tumeurs de la prostate est représentée par l’adénocarcinome prostatique (jusqu’à 95%. Le carcinome épidermoïde primitif est très rare et ne représente que 0,5% à 1% des carcinomes prostatiques. Jusqu’à 2014 seulement 24 cas ont été décrits dans la littérature. Nous rapportons un nouveau cas de carcinome épidermoide primitif de la prostate chez un jeune âgé de 48 ans diagnostiqué à un stade métastatique. Malgré une chimiothérapie à base de Cisplatine et Métoxantrone, le décès est survenu 2 mois après le diagnostic. A travers cette observation et une revue de la littérature, nous discutons les différents aspects cliniques, histologiques, thérapeutiques et pronostiques de cette tumeur.

Development of Core Simulator (CoSi) for APR1400 And Analysis of LPPT Result using APR1400-CoSi

International Nuclear Information System (INIS)

Moon, Sang-Rae; Kim, Yong-Bae; Lee, Eun-Ki

2014-01-01

According to NRC guidelines, Low Power Physics Test (LPPT) is required to be performed in low temperature/low pressure (160 .deg. C/42.2 kg/cm 2 ) as well as NOT/NOP (291.3 .deg. C/158.2 kg/cm 2 ) because Shin-Kori Unit 3 is FOAK nuclear power plant. Low Power Physics Test (LPPT) is essential to verify the nuclear design and robustness of reactor safety. LPPT consists of initial criticality, Point of Adding Heat (POAH), All Rod Out (ARO) Boron Concentration, Isothermal Temperature Coefficient (ITC), Control Rod Worth measurements and so on. KHNP-CRI has developed the Core Simulator for APR1400 (APR1400-CoSi) in order to improve the ability performing the LPPT. Especially, APR1400-CoSi has enhanced capability to calculate the full Core neutronic parameters by revising RAST-K that is three dimensional real time core kinetic program. APR1400-CoSi has been developed for education-training of Low Power Physics Test(LPPT). Particularly, APR1400-CoSi has an enhanced capability to calculate the full core neutronic parameters by revising RAST-K which is a three dimensional real time core kinetics program. Low Power Physics Test (LPPT) was performed using APR1400-CoSi and the results showed very similar values with the predicted ones. In other words, the initial core model of Shin-Kori Unit 3 in APR1400-CoSi system has been verified to be appropriate enough. Also, it was confirmed that the test range of Low Power Physics Test (LPPT) reamains effective even though the largest incremental bank reactivity is inserted in core by analyzing the power change during the rod SWAP test

Development of Reactor Coolant Pump for APR1400

Energy Technology Data Exchange (ETDEWEB)

Bang, Sang-Youn; Chu, Sung-Min; Chang, Jin-Young [Doosan Heavy Industries and Construction, Changwon (Korea, Republic of)

2015-10-15

The development was focused on the performance requirements for APR1400 and to achieve the goals of the safety, reliability and adaptability for APR1400 system design. In addition, APR1400 RCP design was customized considering convenience of installation, operation and maintainability. This paper describes the details of the development process, improved design feature and type test results. Based on development of core technology of RCP, DOOSAN supplies the localized and improved APR1400 RCP to Shin-Hanul 1 and 2 Project. This would be good experience that the RCP core technology can break foreign monopoly in supplying the domestic nuclear industry. Also, there expect APR1400 RCP can be sustainable revenue models in nuclear industry. Moreover, development of RCP will be a catalyst to enhance design capacity for equipment and system of nuclear power plant as well as evaluation and verification skills of Korean nuclear industry.

ITAAC Development for APR1400 NRC Design Certification

International Nuclear Information System (INIS)

Kim, Jin Kwon; Kim, Myoung Ki

2013-01-01

ITAAC (Inspections, Tests, Analyses and Acceptance Criteria) is essential document for Design Certification, which is certified by NRC and ruled as the Appendix of the 10 CFR Part 52. Approximately 870 ITAAC items were selected for APR1400 Design Certification to be submitted to NRC. In this paper, the code and standard related to ITAAC and process of ITACC development are discussed to seek the way to complete the best ITAAC to get the Design Certification of APR1400 from NRC through the lessons learned from other competitive applicants. For saving the time and manpower to complete ITAAC of APR1400 NRC DC and reduction of the RAIs (Request Additional Information) from NRC, we took advantage of the lessons learned from the competitive designs like US-APWR and AP1000 based on KNGR ITAAC. Finally new and different ITAAC from ITAAC of KNGR was developed for APR1400 DC from NRC. RG 1.206 and SRPs were applied first in Korea to the APR1400 DCD preparation. For testability and acceptability check, ITAAC V and V table was completed by the system designers. APR1400 DCD will be submitted by the end of September this year and we hope that NRC issues lees RAIs on ITAAC document

Au XXIème siècle, qui sont les patients dialysés souffrant d'une hyperparathyroïdie secondaire sévère ? Cohorte prospective, multicentrique de patients dialysés, incidents pour l'hyperparathyroïdie secondaire. EPHEYL (Etude PHarmacoEpidémiologique de l'hYperparathyroïdie secondaire en Lorraine)

OpenAIRE

Thomas-Laurain , Emmanuelle

2013-01-01

Non disponible / Not available; L'hyperparathyroïdie secondaire (HPTS) est une complication fréquente de l'insuffisance rénale chronique. Mais son diagnostic et sa prise en charge sont encore complexes et mal codifiés. Dans notre étude, nous faisons l'hypothèse que la population de patients atteints d'HPTS est hétérogène. L'objectif de notre étude était d'identifier des sous-groupes de patients présentant un profil d'HPTS commun à partir des données cliniques, biologiques et thérapeutiques di...

Optimization Strategy of the APR+ BOP Technical Specifications

International Nuclear Information System (INIS)

Cho, Yoon Sang; Lee, Jae Gon; Han, Sung Heum

2016-01-01

The BOP is one of the key factors for successful project implementation of NPP. In constructing the APR1400 NPP, the BOP procurement has been one of the biggest concerns. Due to the design changes and increased capacity of equipment in NPP, lots of BOPs should be ‘first supplied equipment’ [hereinafter, ‘FSE’]. The manufacture-ability, and the performances of FSEs have not been fully proved and tested, manufacturers and suppliers are requested to submit Reports for Equipment Qualification Evaluation in accordance with 10 CFR 50.49, IEEE 323. They need at least 1-2 years’ tests for Environment Qualification (EQ) and Seismic Qualification (SQ). This study is focused how to prepare the BOP purchase specifications in order to control the FSEs, especially in safety class equipment. With the optimization plan for BOP packages of this study, the FSEs’ occurrence can be reasonably controlled as low as possible. For successful NPP project, the concerns in procuring BOPs shall be fully analyzed beforehand. Now Korea is preparing new era of APR+, with closing the time of APR1400. The technical specification of APR+ BOPs can be developed and prepared successfully and very effectively according to this optimization plan. This will be a great contribution not only in constructing APR+ in time, but also in exporting APR+ overseas, all over the world in the future

Optimization Strategy of the APR+ BOP Technical Specifications

Energy Technology Data Exchange (ETDEWEB)

Cho, Yoon Sang; Lee, Jae Gon; Han, Sung Heum [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

The BOP is one of the key factors for successful project implementation of NPP. In constructing the APR1400 NPP, the BOP procurement has been one of the biggest concerns. Due to the design changes and increased capacity of equipment in NPP, lots of BOPs should be ‘first supplied equipment’ [hereinafter, ‘FSE’]. The manufacture-ability, and the performances of FSEs have not been fully proved and tested, manufacturers and suppliers are requested to submit Reports for Equipment Qualification Evaluation in accordance with 10 CFR 50.49, IEEE 323. They need at least 1-2 years’ tests for Environment Qualification (EQ) and Seismic Qualification (SQ). This study is focused how to prepare the BOP purchase specifications in order to control the FSEs, especially in safety class equipment. With the optimization plan for BOP packages of this study, the FSEs’ occurrence can be reasonably controlled as low as possible. For successful NPP project, the concerns in procuring BOPs shall be fully analyzed beforehand. Now Korea is preparing new era of APR+, with closing the time of APR1400. The technical specification of APR+ BOPs can be developed and prepared successfully and very effectively according to this optimization plan. This will be a great contribution not only in constructing APR+ in time, but also in exporting APR+ overseas, all over the world in the future.

The APR1400 Core Design by Using APA Code System

International Nuclear Information System (INIS)

Choi, Yu Sun; Koh, Byung Marn

2008-01-01

The nuclear design for APR1400 has been performed to prepare the core model for Automatic Load Follow Operation Simulation. APA (ALPHA/ PHOENIXP/ ANC) code system is a tool for the multi-cycle depletion calculations for APR1400. Its detail versions for ALPHA, PHOENIX-P and ANC are 8.9.3, 8.6.1 and 8.10.5, respectively. The first and equilibrium core depletion calculations for APR1400 have been performed to assure the target cycle length and confirm the safety parameters. The parameters are satisfied within limitation about nuclear design criteria. This APR1400 core models will be based on the design parameters for APR1400 Simulator

Resultat du traitement d'un craniopharyngiome kystique par de la ...

African Journals Online (AJOL)

Introduction Le craniopharyngiome est une tumeur bénigne qui provient de nids épithéliaux ou de zones de métaplasies squameuses liées à l'embryogenèse hypophysaire. Touchant surtout l'enfant, peut être potentiellement agressive et caractérisée par un taux élevé de récidive après traitement chirurgical. La bléomycine ...

Antenna Pattern Range (APR)

Data.gov (United States)

Federal Laboratory Consortium — TheAntenna Pattern Range (APR)features a non-metallic arch with a trolley to move the transmit antenna from the horizon to zenith. At the center of the ground plane,...

Diagnostic Strategy in APR1400

International Nuclear Information System (INIS)

Kim, Dongyoung; Kim, Jonghyun

2013-01-01

These features may bring out changes in operator tasks, changing the characteristics of tasks, or creating new tasks. Diagnostic strategy for identifying anomaly may be different especially in APR1400 from that in the analog control room due to the change of human-system interface, i.e. alarm system and display system. Since the first plant of APR1400 is being built at this moment, it is not known what strategies the operators will adopt in diagnosis tasks in the new operating environment. In this light, this paper aims at investigating operator's diagnostic strategies which are appropriate for APR1400. In order to collect data, several different approaches which are complementary are used to identify diagnostic strategies in the digital control room: analysis on audio/video recording of operation, observation in the simulator, and interview with the operators. The result shows that the digital control room introduces new strategies in the diagnosis, compared with the analog control room, and also changed the characteristics of strategies, mostly, by getting more support from the computerized system. This paper investigated how the digitalized control room may influence operator's diagnostic strategies. Several different approaches, i. e., audio/video record, observation of training, and the interview with operators, were used to gather information about the operator's behaviors. As a conclusion, this paper figured out that the digital control room introduces new strategies in the diagnosis, compared with the analog control room, and also changed the characteristics of the strategies, mostly, by getting more support from the computerized system. The operators interviewed also commented that the diagnosis in the APR1400 is quicker, more correct, and easier, compared with the analog control room

Diagnostic Strategy in APR1400

Energy Technology Data Exchange (ETDEWEB)

Kim, Dongyoung; Kim, Jonghyun [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2013-05-15

These features may bring out changes in operator tasks, changing the characteristics of tasks, or creating new tasks. Diagnostic strategy for identifying anomaly may be different especially in APR1400 from that in the analog control room due to the change of human-system interface, i.e. alarm system and display system. Since the first plant of APR1400 is being built at this moment, it is not known what strategies the operators will adopt in diagnosis tasks in the new operating environment. In this light, this paper aims at investigating operator's diagnostic strategies which are appropriate for APR1400. In order to collect data, several different approaches which are complementary are used to identify diagnostic strategies in the digital control room: analysis on audio/video recording of operation, observation in the simulator, and interview with the operators. The result shows that the digital control room introduces new strategies in the diagnosis, compared with the analog control room, and also changed the characteristics of strategies, mostly, by getting more support from the computerized system. This paper investigated how the digitalized control room may influence operator's diagnostic strategies. Several different approaches, i. e., audio/video record, observation of training, and the interview with operators, were used to gather information about the operator's behaviors. As a conclusion, this paper figured out that the digital control room introduces new strategies in the diagnosis, compared with the analog control room, and also changed the characteristics of the strategies, mostly, by getting more support from the computerized system. The operators interviewed also commented that the diagnosis in the APR1400 is quicker, more correct, and easier, compared with the analog control room.

Les lémuriens du site Ramsar de Torotorofotsy

African Journals Online (AJOL)

s secondaires qui évoluent vers une formation clima- cique appelée savoka et qui sera à nouveau exploitable après cinq à dix ans de jachère (Kiener 1963, Aubert et al. 2003, Styger et al. 2007). Ce dynamisme de formation végétale entraine un dynamisme d'éparpillement des hameaux en fonction des terrains fertiles.

Pseudomonas syringae evades host immunity by degrading flagellin monomers with alkaline protease AprA.

Science.gov (United States)

Pel, Michiel J C; van Dijken, Anja J H; Bardoel, Bart W; Seidl, Michael F; van der Ent, Sjoerd; van Strijp, Jos A G; Pieterse, Corné M J

2014-07-01

Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of bacterial species. In addition, we investigated the role of AprA in virulence of the bacterial plant pathogen P. syringae pv. tomato DC3000. The AprA-deficient DC3000 ΔaprA knockout mutant was significantly less virulent on both tomato and Arabidopsis thaliana. Moreover, infiltration of A. thaliana Col-0 leaves with DC3000 ΔaprA evoked a significantly higher level of expression of the defense-related genes FRK1 and PR-1 than did wild-type DC3000. In the flagellin receptor mutant fls2, pathogen virulence and defense-related gene activation did not differ between DC3000 and DC3000 ΔaprA. Together, these results suggest that AprA of DC3000 is important for evasion of recognition by the FLS2 receptor, allowing wild-type DC3000 to be more virulent on its host plant than AprA-deficient DC3000 ΔaprA. To provide further evidence for the role of DC3000 AprA in host immune evasion, we overexpressed the AprA inhibitory peptide AprI of DC3000 in A. thaliana to counteract the immune evasive capacity of DC3000 AprA. Ectopic expression of aprI in A. thaliana resulted in an enhanced level of resistance against wild-type DC3000, while the already elevated level of resistance against DC3000 ΔaprA remained unchanged. Together, these results indicate that evasion of host immunity by the alkaline protease AprA is important for full virulence of strain DC3000 and likely acts by preventing flagellin monomers from being recognized by its cognate immune receptor.

Development of Reference Source Terms for EU-APR1400

Energy Technology Data Exchange (ETDEWEB)

Kim, ByungIl; Lee, Chonghui; Lee, Dongsu; Ko, Heejin; Kang, Sangho [KEPCO Engineering and Construction Co. Inc., Yongin (Korea, Republic of)

2014-05-15

These source terms are developed for the typical U. S. NPP and do not reflect the design characteristics of EU-APR1400 (1,400 MWe PWR) which will be applied for the EUR certification in European countries. The process of developing the RST for EU-APR1400 is to undergo a similar process that NUREG-1465 had gone through when it came out with its proposed source terms. The purpose of this study is to develop the EU-APR1400 design-specific RST complied with the EUR. The Large LOCA is the reference equence used in the NUREG-1465 evaluation, whereas the EUAPR1400 risk-significant sequences are dominated by small LOCA and non-LOCA sequences. Moreover, when considering the EU-APR1400 has many design features to mitigate the consequences of severe accident phenomena, it is not surprising that the aspects of both release fractions and durations are distinctly different from NUREG-1465. This RST will be continuously updated to reflect to the design features of EU-APR1400, and then, be used as the reference for design purposes such as criteria satisfaction of radioactivity releases, equipment survivability, control room habitability for severe accident, and so on.

EU-APR Design in compliance with EUR Grid Requirement

Energy Technology Data Exchange (ETDEWEB)

Kim, Dong-Hwan; Lee, Keun-Sung [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

European Utility Requirements (EUR) provides technical requirements for the generation III nuclear power plant in the European countries. EUR grid requirements present the plant requirements to satisfy the needs of the grid network. The grid requirements are the precondition for the operation of a generating plant on the network. This paper describes EU-APR design which has taken account of EUR grid requirements. In this paper, EU-APR designs according to the EUR grid requirements were described. EU-APR was designed in compliance with the voltage and frequency operation field and also designed to have the capability of load following such as primary control, secondary control, and daily load following. Consequently, the EU-APR design according to the EUR grid requirements is expected to get competitiveness and enhance the license feasibility in the European nuclear market.

A Probability Analysis of the Generating Cost for APR1000+

Energy Technology Data Exchange (ETDEWEB)

Ha, Gag-Hyeon; Kim, Dae-Hun [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

The nuclear power plant market is expected to grow rapidly in order to address issues of global warming, cutting CO{sub 2} emissions and securing stable electricity supplies. Under these circumstances, the main primary goal of the APR1000+ development is to ensure export competitiveness in the developing countries in the Middle East and Southeast Asia. To that end, APR1000+(1,000MWe, 3.5 generation) will be developed based on APR+ (1,500MWe, 3.5 generation). And comparing to OPR1000(Korean Standard Nuclear power Plant, 2.5 generation), APR1000+ have many design features such as the 60 year design life time, comprehensive site requirement of 0.3g seismic design, stability improvement, operability improvement and provisions for severe accidents. In this simulation, the results of generating cost for APR1000+ preliminary conceptual design using a probability method was shown to be 48.37 ~ 74.22 won/kWh(median value 56.51 won/kWh). Those of OPR1000 was 42.08 ~ 61.77 won/kWh(median value 48.63 won/kWh). APR1000+ has -16.2% cost advantage over OPR1000 nuclear power plant. The main reason of this results is due to adding several safety designs.

Mise au point

African Journals Online (AJOL)

tomie est replacé et fixé par des fils d'acier, krönlein lais- sait ce fragment pédiculé au fascia temporalis afin d'évi- ter la dépression de la fosse temporale due à la désinser- tion du muscle temporal [20] ; dans notre série, après reconstitution du cadre, le muscle temporal est suturé à son point d'insertion. pour les tumeurs ...

The trauma registry compared to All Patient Refined Diagnosis Groups (APR-DRG).

Science.gov (United States)

Hackworth, Jodi; Askegard-Giesmann, Johanna; Rouse, Thomas; Benneyworth, Brian

2017-05-01

Literature has shown there are significant differences between administrative databases and clinical registry data. Our objective was to compare the identification of trauma patients using All Patient Refined Diagnosis Related Groups (APR-DRG) as compared to the Trauma Registry and estimate the effects of those discrepancies on utilization. Admitted pediatric patients from 1/2012-12/2013 were abstracted from the trauma registry. The patients were linked to corresponding administrative data using the Pediatric Health Information System database at a single children's hospital. APR-DRGs referencing trauma were used to identify trauma patients. We compared variables related to utilization and diagnosis to determine the level of agreement between the two datasets. There were 1942 trauma registry patients and 980 administrative records identified with trauma-specific APR-DRG during the study period. Forty-two percent (816/1942) of registry records had an associated trauma-specific APR-DRG; 69% of registry patients requiring ICU care had trauma APR-DRGs; 73% of registry patients with head injuries had trauma APR-DRGs. Only 21% of registry patients requiring surgical management had associated trauma APR-DRGs, and 12.5% of simple fractures had associated trauma APR-DRGs. APR-DRGs appeared to only capture a fraction of the entire trauma population and it tends to be the more severely ill patients. As a result, the administrative data was not able to accurately answer hospital or operating room utilization as well as specific information on diagnosis categories regarding trauma patients. APR-DRG administrative data should not be used as the only data source for evaluating the needs of a trauma program. Copyright © 2016 Elsevier Ltd. All rights reserved.

Radiation exposure reduction in APR1400

International Nuclear Information System (INIS)

Bae, C. J.; Hwang, H. R.; Matteson, D. M.

2002-01-01

The primary contributors to the total occupational radiation exposure in operating nuclear power plants are operation and maintenance activities during refueling outages. The Advanced Power Reactor 1400 (APR1400) includes a number of design improvements and plans to utilize advanced maintenance methods and robotics to minimize the annual collective dose. The major radiation exposure reduction features implemented in APR1400 are a permanent refueling pool seal, quick opening transfer tube blind flange, improved hydrogen peroxide injection at shutdown, improved permanent steam generator work platforms, and more effective temporary shielding. The estimated average annual occupational radiation exposure for APR1400 based on the reference plant experience and an engineering judgment is determined to be in the order of 0.4 man-Sv, which is well within the design goal of 1 man-Sv. The basis of this average annual occupational radiation exposure estimation is an eighteen (18) month fuel cycle with maintenance performed to steam generators and reactor coolant pumps during refueling outage. The outage duration is assumed to be 28 days. The outage work is to be performed on a 24 hour per day basis, seven (7) days a week with overlapping twelve (12) hour work shifts. The occupational radiation exposure for APR1400 is also determined by an alternate method which consists of estimating radiation exposures expected for the major activities during the refueling outage. The major outage activities that cause the majority of the total radiation exposure during refueling outage such as fuel handling, reactor coolant pump maintenance, steam generator inspection and maintenance, reactor vessel head area maintenance, decontamination, and ICI and instrumentation maintenance activities are evaluated at a task level. The calculated value using this method is in close agreement with the value of 0.4 man-Sv, that has been determined based on the experience and engineering judgement

Carcinome neuroendocrine thymique: à propos d’un cas et revue de la littérature

Science.gov (United States)

Ramahandrisoa, Andriatsihoarana Voahary Nasandratriniavo; Hasiniatsy, Nomeharisoa Rodrigue Emile; Refeno, Valéry; Vololonantenaina, Clairette Raharisolo; Rakotoarisoa, Andriamihaja Jean Claude; Rakotovao, Hanitrala Jean Louis; Rafaramino, Florine

2017-01-01

Les tumeurs neuroendocrines thymiques (TNET) sont rares, de pronostic mal connu. L'objectif est de rapporter un cas de TNET et discuter la difficulté diagnostique et thérapeutique en milieu à faibles ressources. Un homme de 60 ans présentait une douleur thoracique, une toux grasse et un amaigrissement récent. Le scanner thoracique révélait une masse tissulaire médiastinale antérieure. L'histologie définitive obtenue quatre mois après la biopsie par médiastinotomie antérieure montrait une TNET bien différenciée, avec marquage intense à la chromogranine et à la synaptophysine. La recherche d'autres tumeurs neuroendocrines et le bilan d'extension étaient négatifs. La tumeur était inextirpable d'emblée et la radiothérapie indisponible. Le patient a reçu deux lignes de chimiothérapie première. Avec un recul de 16 mois, le patient était asymptomatique, mais en progression tumorale. Le diagnostic de TNET peut être retardé quand l'examen immunohistochimique n'est pas réalisé en routine. La chimiothérapie apporte une amélioration des symptômes en situation palliative. PMID:28451004

APR1400 Locked Rotor Transient Analysis using KNAP

International Nuclear Information System (INIS)

Lee, Dong-Hyuk; Kim, Yo-Han; Ha, Sang Jun

2007-01-01

KEPRI (Korea Electric Power Research Institute) has developed safety analysis methodology for non-LOCA (Loss Of Coolant Accident) analysis of OPR1000 (Optimized Power Reactor 1000, formerly KSNP). The new methodology, named KNAP (Korea Non-LOCA Analysis Package), uses RETRAN as the main system analysis code for most transients. For locked rotor transient DNBR analysis, UNICORN-TM code is used. UNICORN-TM is the unified code of RETRAN, MASTER and TORC. The UNICORN-TM has 1-D and 3-D neutron kinetics calculation capability. For locked rotor DNBR analysis, 1-D neutron kinetics is used. In this paper, we apply KNAP methodology to APR1400 (Advanced Power Reactor 1400) locked rotor analysis and compare the results with those in the APR1400 SSAR(Standard Safety Analysis Report). The locked rotor transient is one of the 'decrease in reactor coolant system flow rate' events and the results are typically described in the chapter 15.3.3 of SAR (Safety Analysis Report). In this study, to confirm the applicability of the KNAP methodology and code system to APR1400, locked rotor transient is analyzed using UNICORN-TM code and the results are compared with those from APR1400 SSAR

APR1400 Locked Rotor Transient Analysis using KNAP

Energy Technology Data Exchange (ETDEWEB)

Lee, Dong-Hyuk; Kim, Yo-Han; Ha, Sang Jun [Korea Electric Power Research Institute, Daejeon (Korea, Republic of)

2007-07-01

KEPRI (Korea Electric Power Research Institute) has developed safety analysis methodology for non-LOCA (Loss Of Coolant Accident) analysis of OPR1000 (Optimized Power Reactor 1000, formerly KSNP). The new methodology, named KNAP (Korea Non-LOCA Analysis Package), uses RETRAN as the main system analysis code for most transients. For locked rotor transient DNBR analysis, UNICORN-TM code is used. UNICORN-TM is the unified code of RETRAN, MASTER and TORC. The UNICORN-TM has 1-D and 3-D neutron kinetics calculation capability. For locked rotor DNBR analysis, 1-D neutron kinetics is used. In this paper, we apply KNAP methodology to APR1400 (Advanced Power Reactor 1400) locked rotor analysis and compare the results with those in the APR1400 SSAR(Standard Safety Analysis Report). The locked rotor transient is one of the 'decrease in reactor coolant system flow rate' events and the results are typically described in the chapter 15.3.3 of SAR (Safety Analysis Report). In this study, to confirm the applicability of the KNAP methodology and code system to APR1400, locked rotor transient is analyzed using UNICORN-TM code and the results are compared with those from APR1400 SSAR.

Design characteristics of EU-APR1400 on-site power system

International Nuclear Information System (INIS)

Kim, D.H.; Kim, Y.S.; Kim, Y.S.

2014-01-01

In the global nuclear market, US and European design requirements have been largely used to develop the design of nuclear power plants(NPPs). The APR1400 design was developed on the basis of US regulatory guide and EPRI utility requirements document(URD). In order to enlarge the export market of APR1400, KHNP (Korea Hydro & Nuclear Power Co., Ltd) has developed the EU-APR1400 design which complies with the European nuclear design requirements. In this paper, the design characteristics of EU-APR1400 on-site power system developed according to the European design requirements of electrical power system are described. The European main design requirements of electrical power system involve 50 Hz rated frequency, 400/110 kV grid voltage, the application of the diversity and the redundancy, and so on. The EU-APR1400 on-site power system has been developed on the basis of these requirements. The representative designs include the redundancy, diversity, independence design, the emergency power supply design, the design for providing electrical power to the dedicated severe accident systems, and the design for European grid requirements. (author)

Favoriser la rencontre entre la littérature et les lycéens

NARCIS (Netherlands)

Rentrop - Weij, Joke|info:eu-repo/dai/nl/314449302; Haenen, Jacques|info:eu-repo/dai/nl/070566135

2014-01-01

Comment engager les élèves à la littérature? Une enseignante de secondaire de FLE et une didacticienne d’une université de FLE aux PaysBas collaborent dans le but général d’inciter les élèves à lire des romans littéraires pendant et après leur vie scolaire. Elles ont développé deux cours de

Pseudomonas syringae evades host Immunity by degrading flagellin monomers with alkaline protease AprA

OpenAIRE

Pel, M.J.C.; Van Dijken, A.J.H.; Bardoel, B.W.; Seidl, M.F; Van der Ent, S.; Van Strijp, J.A.G.

2014-01-01

Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of bacterial species. In addition, we investigated the role of AprA in virulence of the bacterial plant athogen P. syringae pv. tomato DC3000. The AprA-deficient DC3000 ΔaprA knockout mutant was significantl...

APR1400 CEA Withdrawal at Power Accident Analysis using KNAP

International Nuclear Information System (INIS)

Lee, Dong-Hyuk; Yang, Chang-Keun; Kim, Yo-Han; Sung, Chang-Kyung

2006-01-01

KEPRI (Korea Electric Power Research Institute) has been developing safety analysis methodology for non- LOCA (Loss Of Coolant Accident) analysis of OPR1000 (Optimized Power Reactor 1000, formerly KSNP). The new methodology, named KNAP (Korea Non-LOCA Analysis Package), uses RETRAN as the main system analysis code. RETRAN code is a non- LOCA safety analysis code developed by EPRI. The new methodology will replace existing CE (Combustion Engineering) supplied codes and methodologies currently used in non-LOCA analysis of OPR1000. In this paper, we apply KNAP methodology to APR1400 (Advanced Power Reactor 1400). The CEA (Control Element Assembly) withdrawal at power accident is one of the 'reactivity and power distribution anomalies' events and the results are typically described in the chapter 15.4.2 of SAR (Safety Analysis Report). The APR1400 has been designed to generate 1,400MWe of electricity with advanced features for greatly enhanced safety and economic goals. The CEA withdrawal at power analysis in APR1400 SSAR (Standard Safety Analysis Report) is analyzed with CESEC-III computer code. In this study, to confirm the applicability of the KNAP methodology and code system to APR1400, CEA withdrawal at power accident is analyzed using RETRAN code and it is compared with results from APR1400 SSAR

System Response Analysis of LOCV for APR1400 Using KNAP

International Nuclear Information System (INIS)

Kim, Yo-Han; Sung, Chang-Kyung; Jun, Hwang-Yong

2006-01-01

Korea Electric Power Research Institute (KEPRI) of Korea Electric Power Corporation (KEPCO) has been developed the non-loss-of-coolant accident (non-LOCA) analysis methodology, called as the Korea Non-LOCA Analysis Package (KNAP), for the typical Optimized Power Reactor 1000 (OPR1000) plants. Considering current licensing methodology conducted by ABB-CE, however, the KNAP could be applied to Advanced Power Reactor 1400 (APR1400). In spite of some difference in components of two plant types, there is a close resemblance between their nuclear steam supply systems (NSSS). So, in this study, the loss of condenser vacuum (LOCV) event were analyzed using KNAP for APR1400 to estimate the feasibility of the application and the results were compared with those given in APR1400 Standard Safety Analysis Report (SSAR), which were calculated using the CESEC-III code of ABB-CE. Through the study, it was concluded that the KNAP could be applicable to APR1400 on the view point of LOCV event

Functional Requirement Analysis and Function Allocation for APR 1400

International Nuclear Information System (INIS)

Nuraslinda, Anuar; Florah, Kamanja; Noloyiso, Mtoko and others

2013-01-01

This paper intends to fulfill the FRA and FA of the HFE as required in Chapter 4 of NUREG-0711 rev. 3 for APR1400 to satisfy both plant safety and power generation objectives. This paper aims to evaluate the FRA and FA for APR1400. The allocation of function is done at the system level for all processes for both the power generation and safety goals, following the NUREG/CR-3331 guideline. As a conclusion, this paper has successfully implemented the requirements and methodology specified in NUREG-0711 for APR 1400. The Functional Requirement Analysis (FRA) and Function Allocation (FA) are required by the regulation in the Human Factors Engineering (HFE) program. The FRA defines the functions, processes, and system for plant safety and power generation. The FA allocates the functions to human operator, automation, or a combination of two. The FRA and FA for APR1400 have been performed in the very early stage of development but only for the plant safety. However, the analysis did not include the goal of power generation and also did not fully satisfy the latest revision of NUREG-0711

Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV.

Science.gov (United States)

Herlihy, Sarah E; Tang, Yu; Phillips, Jonathan E; Gomer, Richard H

2017-03-01

Autocrine proliferation repressor protein A (AprA) is a protein secreted by Dictyostelium discoideum cells. Although there is very little sequence similarity between AprA and any human protein, AprA has a predicted structural similarity to the human protein dipeptidyl peptidase IV (DPPIV). AprA is a chemorepellent for Dictyostelium cells, and DPPIV is a chemorepellent for neutrophils. This led us to investigate if AprA and DPPIV have additional functional similarities. We find that like AprA, DPPIV is a chemorepellent for, and inhibits the proliferation of, D. discoideum cells, and that AprA binds some DPPIV binding partners such as fibronectin. Conversely, rAprA has DPPIV-like protease activity. These results indicate a functional similarity between two eukaryotic chemorepellent proteins with very little sequence similarity, and emphasize the usefulness of using a predicted protein structure to search a protein structure database, in addition to searching for proteins with similar sequences. © 2016 The Protein Society.

Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl‐peptidase IV

Science.gov (United States)

Herlihy, Sarah E.; Tang, Yu; Phillips, Jonathan E.

2017-01-01

Abstract Autocrine proliferation repressor protein A (AprA) is a protein secreted by Dictyostelium discoideum cells. Although there is very little sequence similarity between AprA and any human protein, AprA has a predicted structural similarity to the human protein dipeptidyl peptidase IV (DPPIV). AprA is a chemorepellent for Dictyostelium cells, and DPPIV is a chemorepellent for neutrophils. This led us to investigate if AprA and DPPIV have additional functional similarities. We find that like AprA, DPPIV is a chemorepellent for, and inhibits the proliferation of, D. discoideum cells, and that AprA binds some DPPIV binding partners such as fibronectin. Conversely, rAprA has DPPIV‐like protease activity. These results indicate a functional similarity between two eukaryotic chemorepellent proteins with very little sequence similarity, and emphasize the usefulness of using a predicted protein structure to search a protein structure database, in addition to searching for proteins with similar sequences. PMID:28028841

A Probability Analysis of the Generating Cost for EU-APR1400 Single Unit

International Nuclear Information System (INIS)

Ha, Gak Hyeon; Kim, Sung Hwan

2014-01-01

The nuclear power plant market is expected to grow rapidly in order to address issues of global warming, reducing CO 2 emissions and securing stable electricity supplies. Under these circumstances, the main primary goal of the EU-APR100 development is to ensure export competitiveness in the European countries. To this end, EU-APR1400 have been developed based one te APR1400 (Advanced Power Reactor, GEN Type) The EU-APR1400 adds many advanced design features to its predecessor, as outlined below in Table 1. In this simulation, the results of the generating cost of the EU-APR1400 single unit were determined using the probability cost analysis technique, the generating cost range was shown to be 56.16 ∼ 70.92 won/kWh.

A Probability Analysis of the Generating Cost for EU-APR1400 Single Unit

Energy Technology Data Exchange (ETDEWEB)

Ha, Gak Hyeon; Kim, Sung Hwan [KHNP CRI, Seoul (Korea, Republic of)

2014-10-15

The nuclear power plant market is expected to grow rapidly in order to address issues of global warming, reducing CO{sub 2} emissions and securing stable electricity supplies. Under these circumstances, the main primary goal of the EU-APR100 development is to ensure export competitiveness in the European countries. To this end, EU-APR1400 have been developed based one te APR1400 (Advanced Power Reactor, GEN Type) The EU-APR1400 adds many advanced design features to its predecessor, as outlined below in Table 1. In this simulation, the results of the generating cost of the EU-APR1400 single unit were determined using the probability cost analysis technique, the generating cost range was shown to be 56.16 ∼ 70.92 won/kWh.

APR1400 Fluidic Device Sensitivity Test

International Nuclear Information System (INIS)

Choi, Nam Hyun; Chu, In Cheol; Min, Kyong Ho; Song, Chul Hwa

2005-12-01

In the safety injection tank at the emergency core cooling system of APR1400, a new safety design feature, passive fluidic device is equipped which includes no active driving system. It is essential to evaluate the new design feature with various experiments. For this reason, three categories of sensitivity tests have been performed in the present study. As the first sensitivity experiment, the effect of the height of the stand pipe was investigated. The second sensitivity test was conducted with removing the insert plate gasket to examine its effect. The effect of the expansion of the control nozzle width was ascertained from the third sensitivity test. The results of each test showed that the passive fluidic device which will be equipped in the SIT tank of APR1400 has great integrity and repeatability

Evaluation of the Planned Outage Durations in EU-APR

Energy Technology Data Exchange (ETDEWEB)

Jung, Byung Joon; Lee, Keun Sung [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

EU-APR has been designed to comply with European Utility Requirements (EUR) and nuclear design requirements of the European countries. And it is modified and improved from its original design of APR1400. The whole duration varies depending on items for additional process. Refueling and regular maintenance outage is comprised of basic processes and Main turbine-generator outage includes dismantling inspection of main generator and high pressure turbine as a critical path in addition to basic processes. In-Service Inspection Outage includes Automatic ultrasonic inspection on the upper side/lower side of a nuclear reactor as a critical path in addition to basic processes. The planned outage durations of EU-APR are optimized according to the above results. And they are complied with EUR Requirement (EUR 2.2.7.2.2 B), respectively. In addition, outage duration can be reduced with improved operating technology and more maintenance friendly environment including betterment of filling, drain and ventilation.

Evaluation of the Planned Outage Durations in EU-APR

International Nuclear Information System (INIS)

Jung, Byung Joon; Lee, Keun Sung

2016-01-01

EU-APR has been designed to comply with European Utility Requirements (EUR) and nuclear design requirements of the European countries. And it is modified and improved from its original design of APR1400. The whole duration varies depending on items for additional process. Refueling and regular maintenance outage is comprised of basic processes and Main turbine-generator outage includes dismantling inspection of main generator and high pressure turbine as a critical path in addition to basic processes. In-Service Inspection Outage includes Automatic ultrasonic inspection on the upper side/lower side of a nuclear reactor as a critical path in addition to basic processes. The planned outage durations of EU-APR are optimized according to the above results. And they are complied with EUR Requirement (EUR 2.2.7.2.2 B), respectively. In addition, outage duration can be reduced with improved operating technology and more maintenance friendly environment including betterment of filling, drain and ventilation

Current status of integrated HFE V and V system of APR1400

International Nuclear Information System (INIS)

Lee, M. S.; Hong, J. H.; Lee, S. H.; Lee, Y. K.

2006-01-01

The first Advanced Light Water Reactor called Advanced Power Reactor (APR1400) has many specific features such as passive safety features, digital I and C, and digitalized main control room design. This digital-based neo-concept main control room design needs comprehensive verification and validation process to get the license for construction. An integrated system for APR1400 MMIS design validation is under development by KEPRI with the participating of KHNP. The facility which is based on the NUREG/CR-6393 and ANS3.5 can simulate all of the dynamic functions and responses of APR1400, and measure the human factors by using conventional subject methods and measuring the operator's biological signals. This system will be used in human factors V and V process of the PRM (NUREG0711) of APR1400 MMIS design. (authors)

Study on Maintenance Personnel Development Plan For The Exported APR1400 Commissioning

International Nuclear Information System (INIS)

Cho, Sungbae; Kim, Jongdae; Jun, Hokwang; Hwang, Inok; Kang, Jaeyuel

2012-01-01

This paper indicates ways to develop maintenance personnel for the exported APR1400 commissioning. The exported APR1400 has not been experienced ay maintenance yet, and requirements for maintenance personnel have not been clarified yet. Based on sound maintenance experience, KEPCO Plant Service and Engineering Company (KEPCO KPS) has studied on maintenance training and career requirement to establish a development plan of the maintenance personnel for the exported nuclear power plant. By defining manpower and training requirement, and mobilization plan, we expect to secure reliability of the exported APR1400

Les représentations des métiers des adolescent(e-s) scolarisé(e-s) dans l’enseignement secondaire

OpenAIRE

Stevanovic, Biljana; Mosconi, Nicole

2011-01-01

À la demande de la Direction de l’animation de la recherche, des études et des statistiques (DARES) du ministère du Travail et des affaires sociales qui a financé et en convention avec l’université Paris X-Nanterre, une étude de la littérature a été élaborée sur les représentations des métiers chez les adolescentes et les adolescents scolarisé(e-s) dans l’enseignement secondaire afin de comprendre pourquoi filles et garçons font des projets professionnels aussi différenciés. L’objectif de cet...

48 CFR 1552.235-76 - Treatment of Confidential Business Information (APR 1996).

Science.gov (United States)

2010-10-01

... Business Information (APR 1996). 1552.235-76 Section 1552.235-76 Federal Acquisition Regulations System... Provisions and Clauses 1552.235-76 Treatment of Confidential Business Information (APR 1996). As prescribed in 1535.007-70(c), insert the following clause: Treatment of Confidential Business Information (TSCA...

Blast pulmonaire primaire chez le brûlé. a propos d’un cas et revue de la littérature

Science.gov (United States)

Siah, S.; Emane, A.; Bertin-Maghit, M.

2016-01-01

Summary Le blast est à l’origine de lésions spécifiques pour lesquelles une prise en charge spécialisée est nécessaire. Après une explosion on peut observer des lésions de blast primaire, liées à l’onde de choc, secondaire par polycriblage et tertiaire par projection du patient. Les blasts secondaire et tertiaire sont plus fréquents que le blast primaire et peuvent entraîner un polytraumatisme. Dans 5% des cas, on retrouve des brûlures pouvant faire partie du blast quaternaire, qui regroupe toutes les lésions d’autres mécanismes que ceux précités. La prise en charge des lésions secondaires et tertiaires de blast est comparable à celle des traumatisés graves. Le blast pulmonaire primaire aggrave le pronostic des blessés les plus graves mais impose rarement une prise en charge spécifique. La connaissance des particularités physiopathologiques et lésionnelles permet de mieux traiter les blastés et brûlés graves survivants. Nous rapportons une observation de blast pulmonaire primaire chez un brûlé. PMID:28149247

Implementasi Automatic Packet Reporting System (APRS) Untuk Paket Data Pemantauan dan PengukuranUntuk Paket Data Pemantauan dan Pengukuran

OpenAIRE

Arief Goeritno

2016-01-01

Telah dilakukan implementasi Automatic Packet Reporting System (APRS) untuk paket data pemantauan dan pengukuran melalui tujuan penelitian, berupa: a) penyetelan program aplikasi pada jaringan APRS dan b) pengukuran terhadap penerimaan data berdasarkan kinerja sensor-sensor. Penyetelan program aplikasi APRS merupakan konfigurasi perangkat lunak untuk APRS yang akan digunakan pada stasiun penerimaan data APRS dengan program aplikasi yang biasa digunakan, yaitu hyperterminal dan UI-View 32. Pen...

Radioiodinated (I{sup 131} and I{sup 125}) Fibrinogen for the Detection of Malignant Tumours in Man; Emploi de Fibrinogene Marque avec {sup 131}I ou {sup 125}I pour la Detection de Tumeurs Malignes chez l'Homme; Primenenie mechennogo radioaktivnym Jodom-131 i Jodom-125 fibrinogena dlya obnaruzheniya zlokachestvennykh opukholej u cheloveka; Empleo el Fibrinogeno Radioyodado ({sup 131}I y {sup 125}I) para la Deteccion de Tumores Malignos en el Hombre

Energy Technology Data Exchange (ETDEWEB)

Monasterio, G.; Becchini, M. F.; Riccioni, N. [Centre of Nuclear Medicine, Medical Clinic, University of Pisa (Italy)

1964-10-15

fibrinogene marque avec {sup 1}'3{sup 1}I a donne des resultats corrects dans 79% des cas examines; aucun resultat faussement positif n'a ete enregistre sur toute la serie. Le memoire expose succinctement le procede et les resultats. D'apres les donnees obtenues, il semble que le fibrinogene marque avec {sup 131}l puisse etre utilise avec succes pour la detection precoce de tumeurs malignes chez l'homme; en ameliorant la technique de detection, il sera peut-etre possible d'augmenter sensiblement la valeur du diagnostic etabli par ce procede. (author) [Spanish] Se ha demostrado que en muchos tumores malignos, tanto en los inducidos en animales de laboratorio como en los formados espontaneamente en el hombre, hay un elevado contenido de fibrina-, se ha establecido una relacion entre este hecho y la gran cantidad de tromboplastina presente en el tumor, que seria lo que provoca la formacion de fibrina por polimerizacion del fibrinogeno. Teniendo esto en cuenta, los autores emplearon fibrinogeno humano marcado con {sup 131}I y {sup 125}l para detectar tumores malignos en el hombre. Estudiaron la absorcion del fibrinogeno radioyodado en tumores malignos y benignos y en lesiones no neoplasticas extensas. Han examinado hasta ahora 73 casos, constituidos 53 de ellos por tumores malignos localizados en el esqueleto, los pulmones, el cerebro, el tubo digestivo, etc. El ensayo de absorcion del fibrinogeno-{sup 131}I dio resultados correctos en el 79% de los casos; en toda la serie no se dio ningun resultado erroneamente positivo. Los autores discuten brevemente la tecnica y los resultados obtenidos. Los datos que ha sido posible reunir parecen indicar que el fibrinogeno-{sup 131}I puede utilizarse con exito para la deteccion temprana de formaciones malignas en el hombre; es probable que perfeccionando la tecnica de deteccion se logre aumentar notablemente el valor diagnostico del metodo. (author) [Russian] V bol'shom kolichestve zlokachestvennyh opuholej kak jeksperimental'nym putem, tak

48 CFR 1552.235-75 - Access to Toxic Substances Control Act Confidential Business Information (APR 1996).

Science.gov (United States)

2010-10-01

... Control Act Confidential Business Information (APR 1996). 1552.235-75 Section 1552.235-75 Federal... Confidential Business Information (APR 1996). As prescribed in 1535.007(b), insert the following provision: Access to Toxic Substances Control Act Confidential Business Information (APR 1996) In order to perform...

Syndrome de loge aiguë secondaire à une injection intraveineuse d ...

African Journals Online (AJOL)

Il s'agit d'un patient âgé de 27 ans, connu toxicomane depuis 2008 qui a présenté un syndrome de loge aigu suite à une injection d'héroïne en intraveineuse au niveau du pli du coude du membre supérieur droit. Le patient a consulté aux urgences 6 heures après l'injection d'héroïne, l'examen clinique initial a trouvé une ...

Insecticidal activity of the metalloprotease AprA occurs through suppression of host cellular and humoral immunity.

Science.gov (United States)

Lee, Seung Ah; Jang, Seong Han; Kim, Byung Hyun; Shibata, Toshio; Yoo, Jinwook; Jung, Yunjin; Kawabata, Shun-Ichiro; Lee, Bok Luel

2018-04-01

The biochemical characterization of virulence factors from entomopathogenic bacteria is important to understand entomopathogen-insect molecular interactions. Pseudomonas entomophila is a typical entomopathogenic bacterium that harbors virulence factors against several insects. However, the molecular actions of these factors against host innate immune responses are not clearly elucidated. In this study, we observed that bean bugs (Riptortus pedestris) that were injected with P. entomophila were highly susceptible to this bacterium. To determine how P. entomophila counteracts the host innate immunity to survive within the insect, we purified a highly enriched protein with potential host insect-killing activity from the culture supernatant of P. entomophila. Then, a 45-kDa protein was purified to homogeneity and identified as AprA which is an alkaline zinc metalloprotease of the genus Pseudomonas by liquid chromatography mass spectrometry (LC-MS). Purified AprA showed a pronounced killing effect against host insects and suppressed both host cellular and humoral innate immunity. Furthermore, to show that AprA is an important insecticidal protein of P. entomophila, we used an aprA-deficient P. entomophila mutant strain (ΔaprA). When ΔaprA mutant cells were injected to host insects, this mutant exhibited extremely attenuated virulence. In addition, the cytotoxicity against host hemocytes and the antimicrobial peptide-degrading ability of the ΔaprA mutant were greatly decreased. These findings suggest that AprA functions as an important insecticidal protein of P. entomophila via suppression of host cellular and humoral innate immune responses. Copyright © 2017 Elsevier Ltd. All rights reserved.

Radiological Impacts Assessment during Normal Decommissioning Operation for EU-APR

Energy Technology Data Exchange (ETDEWEB)

Hwang, Do Hyun; Lee, Keun Sung [KHNP CRI, Daejeon (Korea, Republic of); Lee, ChongHui [KEPCO Engineering and Construction, Gimcheon (Korea, Republic of)

2016-10-15

In this paper, radiological impacts on human beings during normal execution of the decommissioning operations from the current standard design of EU-APR which has been modified and improved from its original design of APR1400 to comply with EUR, are evaluated. Decommissioning is the final phase in the life cycle of a nuclear installation, covering all activities from shutdown and removal of fissile material to environmental restoration of the site. According to article 5.4 specified in chapter 2.20 of European Utility Requirements (EUR), all relevant radiological impacts on human being should be considered during the environmental assessment of decommissioning, including external exposure from direct radiation of plant and other radiation sources, and internal exposure due to inhalation and ingestion. In this paper, radiological impacts on human beings during normal circumstances of the decommissioning operation were evaluated from the current standard design of EU-APR based on the simple transport model and practical generic methodology for assessing the radiological impact provided by IAEA. The results of dose assessment fulfilled the dose limit for all scenarios.

GOTHIC Simulation of APR1400 Auxiliary Charging Pump room heat up

Energy Technology Data Exchange (ETDEWEB)

Ha, Hui-Un; Heo, Sun [KHNP, Daejeon (Korea, Republic of)

2014-10-15

As a part of the Advanced Power Reactor 1400 (APR1400) U. S. Nuclear Regulatory Commission Design Certification (NRC DC) project, we have been investigating Auxiliary Charging Pump (ACP) room heat up. With reference to the design specification of the ACP room, we determined input information and developed a GOTHIC model of the APR1400 ACP room. This calculation model is described herein, and representative results from the calculation are presented as well. The results of the present paper are used to determine the integrity of ACP operating in the accident. APR 1400 GOTHIC model was developed for ACP room heat up calculation. Calculation results confirm that door opening is cooling the room properly. It is found that the difference due to the surface option of heat conductors is insignificant. Based on this result, further studies should be performed to confirm integrity of ACP.

Conceptual Designs for the Performance Improvement of APR1400 SIT and Preliminary Performance Evaluation

International Nuclear Information System (INIS)

Chu, In-Cheol; Kwon, Tae-Soon; Song, Chul-Hwa

2008-01-01

Some evolutionary type PWRs such as APR1400 and APWR adopt advanced safety injection tank (SIT). The SIT of APR1400 has a fluidic device (FD) which passively controls ECC water injection flow rate into reactor coolant system during refill and reflood phases of LB-LOCA (i.e., a high injection flow rate during the refill phase and a low injection flow rate during the reflood phase). The benefit of the FD is the elimination of the function of low pressure safety injection pump from the safety injection system. The flow controlling performance of the APR1400 FD was evaluated using a prototypical full-scale test facility, called VAPER (Valve Performance Evaluation Rig). Even though the performance of the APR1400 FD satisfied major design and licensing requirements, further improvement of the performance is expected such as the extension of total injection period, the delay of nitrogen gas discharge. Several conceptual designs have been being drawn out in order to improve the performance of the APR1400 SIT. The performance of some designs was evaluated using a small scale SIT test rig. The present paper introduces some of the conceptual designs and shows the performance evaluation experimental results

Development of LBB Piping Evaluation Diagram for APR 1000 Main Steam Line Piping

International Nuclear Information System (INIS)

Yang, J. S.; Jeong, I. L.; Park, C. Y.; Bai, S. Y.

2010-01-01

This paper presents the piping evaluation diagram (PED) to assess the applicability of Leak-Before- Break(LBB) for APR 1000 main steam line piping. LBB-PED of APR 1000 main steam line piping is independent of its piping geometry and has a function of the loads applied in piping system. Also, in order to evaluate LBB applicability during construction process with only the comparative evaluation of material properties between actually used and expected, the expected changes of material properties are considered in the LBB-PED. The LBB-PED, therefore, can be used for quick LBB evaluation of APR 1000 main steam line piping of both design and construction

Review of APR+ Level 2 PSA

International Nuclear Information System (INIS)

Lehner, J.R.; Mubayi, V.; Pratt, W.T.

2012-01-01

Brookhaven National Laboratory (BNL) assisted the Korea Institute of Nuclear Safety (KINS) in reviewing the Level 2 Probabilistic Safety Assessment (PSA) of the APR+ Advanced Pressurized Water Reactor (PWR) prepared by the Korea Hydro and Nuclear Power Co., Ltd (KHNP) and KEPCO Engineering and Construction Co., Inc. (KEPCO-E and C). The work described in this report involves a review of the APR+ Level 2 PSA submittal (Ref. 1). The PSA and, therefore, the review is limited to consideration of accidents initiated by internal events. As part of the review process, the review team also developed three sets of Requests for Additional Information (RAIs). These RAIs were provided to KHNP and KEPCO-E and C for their evaluation and response. This final detailed report documents the review findings for each technical element of the PSA and includes consideration of all of the RAIs made by the reviewers as well as the associated responses. This final report was preceded by an interim report (Ref. 2) that focused on identifying important issues regarding the PSA. In addition, a final meeting on the project was held at BNL on November 21-22, 2011, where BNL and KINS reviewers discussed their preliminary review findings with KHNP and KEPCO-E and C staffs. Additional information obtained during this final meeting was also used to inform the review findings of this final report. The review focused not only on the robustness of the APR+ design to withstand severe accidents, but also on the capability and acceptability of the Level 2 PSA in terms of level of detail and completeness. The Korean nuclear regulatory authorities will decide whether the PSA is acceptable and the BNL review team is providing its comments for KINS consideration. Section 2.0 provides the basis for the BNL review. Section 3.0 presents the review of each technical element of the PSA. Conclusions and a summary are presented in Section 4.0. Section 5.0 contains the references.

Development of Nanosatellite Technology with APRS Module for Disaster Mitigation

Science.gov (United States)

Prahyang, S. Y.; Dhiya’Ulhaq, M. Z.; Golim, O. P.; Gunawan, R.; Suhandinata; Jahja, E.; Nelwan, E. R. G.; Ananta, C.; Chow, I. M.; Mali, N. D. F.

2018-05-01

Development of nanosatellite technology has enabled satellites to be developed with multiple capabilities for a specific mission in a short time with a low cost. Satellite communications are proved to be more effective in delivering information due to its large coverage area. Surya Satellite-1 will become the first Indonesian nanosatellite developed by undergraduate students. It is designed with low-cost commercial payloads, including an APRS module for communication and operated on VHF and UHF amateur radio frequencies. The mission of the satellites focused on disaster mitigation through APRS communication network with remote stations located on disaster-prone areas.

Probability Analysis of the Construction Cost of an APR1000 Single Unit

International Nuclear Information System (INIS)

Ha, Gak Hyeon; Suh, Yong Pyo; Kang, Yong Chul

2011-01-01

The nuclear power plant market is expected to grow rapidly in order to address issues of global warming, cutting CO 2 emissions and securing stable electricity supplies. Under these circumstances, the main primary goal of the APR1000 development is to ensure export competitiveness in the developing countries in the Middle East and Southeast Asia. To that end, APR1000 (1,000MWe, 3 rd generation) will be developed based on the OPR1000 (Korean standard nuclear power plant, 2.5 generation) by incorporating and improving the general requirements such as the 60 year design life time, comprehensive site requirement of 0.3g seismic design, stability improvement, operability improvement and provisions for severe accidents. The APR1000 adds 16 advanced design features to its predecessor, as outlined below in Table 1

Evaluation of the Main Steam Line Break Accident for the APR+ Standard Design using MARS-KS

Energy Technology Data Exchange (ETDEWEB)

Park, M. H.; Kim, Y. S.; Hwang, Min Jeong; Sim, S. K. [Environment Energy Technology, Daejeon (Korea, Republic of); Bang, Young Seok [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2015-05-15

As a part of licensing evaluation of the APR+ (Advanced Power Reactor +) standard design, Korea Institute of Nuclear Safety(KINS) performed safety evaluation of the APR+ Standard Safety Analysis Report(SSAR). The results of the safety evaluation of the APR+ Main Steam Line Break(MSLB) accident is presented for the most limiting post-trip return-to-power case with the single failure assumption of the Loss Of Offsite Power(LOOP). MARS-KS regulatory safety analysis code has been used to evaluate safety as well as the system behavior during MSLB accident. The MARS-KS analysis results are compared with the results of the MSLB safety analysis presented in the SSAR of the APR+. Independent safety evaluation has been performed using MARS-KS regulatory safety analysis code for the APR+ MSLB accident inside containment for the limiting case of the full power post-trip return-to-power. The results of MARS-KS analysis were compared with the results of the MSLB safety analysis presented in the APR+ SSAR. Due to higher cooldown of the MARS-KS analysis, the MARS-KS analysis results in a higher positive reactivity insertion into the core by the negative moderator and fuel temperature reactivity coefficients than the APR+ SSAR analysis. Both results show no return-to-power during the limiting case of the MSLB inside containment. However, APR+ SSAR moderator temperature reactivity insertion should be evaluated against the MARS-KS moderator density reactivity insertion for is conservatism. This study also clearly shows asymmetric thermal hydraulic behavior during the MSLB accident at intact and affected sides of the downcomer and the core. These asymmetric phenomena should be further investigated for the effects on the system design.

Pseudomonas syringae evades host immunity by degrading flagellin monomers with alkaline protease AprA

NARCIS (Netherlands)

Pel, Michiel J C; van Dijken, Anja J H; Bardoel, Bart W; Seidl, Michael F; van der Ent, Sjoerd; van Strijp, Jos A G; Pieterse, Corné M J

Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of

Pseudomonas syringae evades host Immunity by degrading flagellin monomers with alkaline protease AprA

NARCIS (Netherlands)

Pel, M.J.C.; Van Dijken, A.J.H.; Bardoel, B.W.; Seidl, M.F; Van der Ent, S.; Van Strijp, J.A.G.

2014-01-01

Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of

Quantitative Safety Impact of Severe Accident Management Systems for EU-APR during Low Power Shutdown Operation

International Nuclear Information System (INIS)

Lee, Keunsung; Hwang, Do Hun; Chang, Hyun-bin

2016-01-01

In order to enlarge and to diversify the export market of APR1400, the EU-APR design was developed based on the APR1400 design to comply with the latest version of the European Utility Requirements (EUR) revision D. The EU-APR design has the distinguished and advanced severe accident management systems taken from the APR1400 to obtain a containment integrity for the beyond design basis accident, such as the Passive Ex-vessel retaining and Cooling System (PECS), the Severe Accident Containment Spray System (SACSS) and the Containment Filtered Vent System (CFVS). The risk associated with the nuclear power plant can be identified through the Probabilistic Safety Assessment (PSA). In the EUR chapter 1 and 17 of volume 2, the Criteria for Limited Impact (CLI) should be applied to the Level 2 PSA as a risk metrics. The fraction of exceeding CLI for the EU-APR during LPSD operation was calculated as 4.52% of the CDF under the condition that all severe accident management systems are credited. The PECS, SACSS and CFVS are considered as the severe accident management system which is EU-APR dedicated system. The exemption of each system leads to increase the fraction of exceeding CLI to 54.18%, 89.74% and 21.32% respectively. In case if all these systems are unavailable, the fraction of exceeding CLI is increased to 100%. The most effective system is the SACSS that the system reduces containment pressure and temperature

Quantitative Safety Impact of Severe Accident Management Systems for EU-APR during Low Power Shutdown Operation

Energy Technology Data Exchange (ETDEWEB)

Lee, Keunsung; Hwang, Do Hun [KHNP CRI, Daejeon (Korea, Republic of); Chang, Hyun-bin [Future and Challenge Technology Co., Yongin (Korea, Republic of)

2016-10-15

In order to enlarge and to diversify the export market of APR1400, the EU-APR design was developed based on the APR1400 design to comply with the latest version of the European Utility Requirements (EUR) revision D. The EU-APR design has the distinguished and advanced severe accident management systems taken from the APR1400 to obtain a containment integrity for the beyond design basis accident, such as the Passive Ex-vessel retaining and Cooling System (PECS), the Severe Accident Containment Spray System (SACSS) and the Containment Filtered Vent System (CFVS). The risk associated with the nuclear power plant can be identified through the Probabilistic Safety Assessment (PSA). In the EUR chapter 1 and 17 of volume 2, the Criteria for Limited Impact (CLI) should be applied to the Level 2 PSA as a risk metrics. The fraction of exceeding CLI for the EU-APR during LPSD operation was calculated as 4.52% of the CDF under the condition that all severe accident management systems are credited. The PECS, SACSS and CFVS are considered as the severe accident management system which is EU-APR dedicated system. The exemption of each system leads to increase the fraction of exceeding CLI to 54.18%, 89.74% and 21.32% respectively. In case if all these systems are unavailable, the fraction of exceeding CLI is increased to 100%. The most effective system is the SACSS that the system reduces containment pressure and temperature.

Design features of Advanced Power Reactor (APR) 1400 steam generator

International Nuclear Information System (INIS)

Park, Tae-Jung; Park, Jun-Soo; Kim, Moo-Yong

2004-01-01

Advanced Power Reactor 1400 (APR 1400) which is to achieve the improvement of the safety and economical efficiency has been developed by Korea Hydro and Nuclear Power Co., Ltd. (KHNP) with the support from industries and research institutes. The steam generator for APR 1400 is an evolutionary type from System 80 + , which is the recirculating U-tube heat exchanger with integral economizer. Compared to the System 80 + steam generator, it is focused on the improved design features, operating and design conditions of APR 1400 steam generator. Especially, from the operation experience of Korean Standard Nuclear Power Plant (KSNP) steam generator, the lessons-learned measures are incorporated to prevent the tube wear caused by flow-induced vibration (FIV). The concepts for the preventive design features against FIV are categorized to two fields; flow distribution and dynamic response characteristics. From the standpoint of flow distribution characteristics, the egg-crate flow distribution plate (EFDP) is installed to prevent the local excessive flow loaded on the most susceptible tube to wear. The parametric study is performed to select the optimum design with the efficient mitigation of local excessive flow. ATHOS3 Mod-01 is used and partly modified to analyze the flow field of the APR 1400 steam generator. In addition, the upper tube bundle support is designed to eliminate the presence of tube with a low natural frequency. Based on the improved upper tube bundle support, the modal analysis is performed and compared with that of System 80 + . Using the results of flow distribution and modal analysis, the two mechanisms of flow-induced vibration are investigated; fluid-elastic instability (FEI) and random turbulence excitation (RTE). (authors)

Questions de mathématiques élémentaires à l'usage des candidats aux écoles du Gouvernement, des aspirants au baccalauréat ès sciences et des élèves des établissements d'enseignement secondaire

CERN Document Server

Vuibert, Henry

1879-01-01

Questions de mathématiques élémentaires à l'usage des candidats aux écoles du Gouvernement, des aspirants au baccalauréat ès sciences et des élèves des établissements d'enseignement secondaire

Non-Integrated Standalone Tests of APR1400 Simulator

International Nuclear Information System (INIS)

Hwang, Su Hyun; Lee, Jeong Ik; Hong, Soon Joon; Lee, Byung Chul; Seo, Jeong Gwan; Lee, Myung Soo

2007-01-01

APR1400 being developed for the construction of New Kori 3 and 4 Units has improved safety and more economical efficiency compared with previous PWR. The ESF(Engineered Safety Features) newly introduced to enhance safety are as follows: DVI (Direct Vessel Injection), Fluidic Device, IRWST (In-containment Refueling Water Storage Tank). So the transient pattern of anticipated accidents will show different characteristics from previous PWR. There are multidimensional flow phenomena like as emergency core cooling coolant bypass discharge in the downcomer, downcomer boiling, and different safety injection characteristics due to fluidic device during LBLOCA. Also there is the phenomenon of critical flow due to the open of pressurizer POSRV (Pilot Operated Safety Relief valve) connected to IRWST and safety depressurization system and the prediction of discharge flow is very important. KEPRI is developing APR1400 simulator using RELAP-RT . RELAP-RT was developed by DS and S (Data systems and Solutions) based on RELAP5/MOD3.2. The improved features of RELAP-RT to function as a simulator are as follows: Add simulator functionality - Control by simulator executive - IC snap and reset capability - Back-track snap and reset capability - Fast time capability. Fast time capability(examples) - The rate of condensation has been limited. - Fictional choking model has been developed for internal junctions. - Wall heat transfer coefficients and heat fluxes has been limited. In this study, various NISTs (Non-Integrated Standalone Tests) were performed to verify the capability of RELAP-RT as APR1400 simulator by the comparison with RELAP5/MOD3.3

ASPECTS NUTRITIONNELS DES ACIDES GRAS POLYINSATURES n-3 Augmentation sélective de la sensibilité des tumeurs à la chimiothérapie par les acides gras polyinsaturés n-3

Directory of Open Access Journals (Sweden)

Bougnoux Philippe

2000-01-01

Full Text Available L’alimentation intervient à différents niveaux dans le déroulement de la maladie cancéreuse : au niveau du risque [1] et au niveau de l’évolution en modifiant le risque de survenue des métastases. L’alimentation influence-t-elle aussi la réponse aux traitements anticancéreux ? À l’appui de cette hypothèse viennent deux observations indirectes réalisées dans le cancer du sein : nos données [2, 3] ainsi que les observations épidémiologiques provenant d’autres travaux [4] ont apporté des arguments supportant l’hypothèse que les lipides alimentaires peuvent influencer la réponse des tumeurs mammaires aux traitements. On sait que la composition des lipides membranaires n’est pas génétiquement déterminée, mais qu’elle dépend des acides gras disponibles aux tissus périphériques. Le type d’acides gras disponibles est influencé par les apports alimentaires. Comme les tumeurs incorporent dans leurs lipides les acides gras disponibles de façon similaire aux autres tissus [5], il est plausible que les habitudes alimentaires (apports alimentaires en acides gras polyinsaturés, vitamines anti ou pro-oxydantes puissent influencer leur chimiosensibilité en apportant aux cellules tumorales des substrats de peroxydation.

APR-246/PRIMA-1Met Inhibits and Reverses Squamous Metaplasia in Human Conjunctival Epithelium.

Science.gov (United States)

Li, Jing; Li, Cheng; Wang, Guoliang; Liu, Zhen; Chen, Pei; Yang, Qichen; Dong, Nuo; Wu, Huping; Liu, Zuguo; Li, Wei

2016-02-01

Squamous metaplasia is a common pathologic condition in ocular surface diseases for which there is no therapeutic medication in clinic. In this study, we investigated the effect of a small molecule, APR-246/PRIMA-1(Met), on squamous metaplasia in human conjunctival epithelium. Human conjunctival explants were cultured for up to 12 days under airlifting conditions. Epithelial cell differentiation and proliferation were assessed by Cytokeratin 10 (K10), K14, K19, Pax6, MUC5AC, and p63 immunostaining patterns. β-catenin and TCF-4 immunofluorescent staining and real-time PCR characterized Wnt signaling pathway involvement. Pterygium clinical samples were cultured under airlifting conditions with or without APR-246 for 4 days. p63, K10, β-catenin, and TCF-4 expression in pterygial epithelium was determined by immunofluorescent staining and real-time PCR. Airlift conjunctival explants resulted in increased stratification and intrastromal epithelial invagination. Such pathology was accompanied by increases in K10, K14, and p63 expression, whereas K19 and Pax6 levels declined when compared to those in freshly isolated tissue. On the other hand, APR-246 reversed all of these declines in K10, K14, and p63 expression. Furthermore, K19 and Pax6 increased along with rises in goblet cell density. These effects of APR-246 were accompanied by near restoration of normal conjunctival epithelial histology. APR-246 also reversed squamous metaplasia in pterygial epithelium that had developed after 4 days in ex vivo culture. Reductions in squamous metaplasia induced by APR-246 suggest it may provide a novel therapeutic approach in different squamous metaplasia-associated ocular surface diseases.

Preliminary Results Of LOCA Problem For APR1400 Reactor

International Nuclear Information System (INIS)

Le Dai Dien; Hoang Minh Giang; Le Thi Thu; Vo Thi Huong; Le Van Hong

2011-01-01

Several features of NPP with APR1400 nuclear reactor during a loss of coolant accident (LOCA) are investigated in this study. The report describes some main design characteristics of an engineering safety systems of APR1400 and the thermal hydraulic calculation results for steady-state using MARS and RELAP/SCDAPSIM codes. Large Break LOCA accident has been analyzed and evaluated based on acceptable criteria for ECCS given by US NRC. The results from cold leg break LOCA with broken area of 0.0465 m 2 in case of high pressure safety injection system (HPSI) failed to operate or 2 and 4 HPSI pumps are activated. The preliminary results of this work is a part of collaboration between INST researchers and KAERI experts in using RELAP tool for safety analysis of NPPs. (author)

The Ongoing Rediscovery of Après-Coup as a Central Freudian Concept.

Science.gov (United States)

House, Jonathan

2017-10-01

Après-coup, Freud's Nachträglichkeit, is an essential psychoanalytic concept structuring each of four concepts, four mental processes that lie at the foundation of Freud's thinking: psychic trauma, repression, the creation of the unconscious, and the creation of infantile sexuality. It is argued here that infantile sexual drives, in contrast to the self-preservative instincts, arise from a two-step process of translation and repression in which the residues of failed translation become source-objects of the drives. These residues of failed translation have an associative resonance with adult sexuality, and the child is driven to ongoing attempts to translate them, to make them meaningful après coup. Thus, après-coup is at the heart of the human subject as a sexual creature who requires, desires, and creates meaning.

Deletion of aprA and nprA genes for alkaline protease A and neutral protease A from bacillus thuringiensis: effect on insecticidal crystal proteins.

Science.gov (United States)

Tan, Y; Donovan, W P

2001-11-17

The aprA gene encoding alkaline protease A (AprA) was cloned from Bacillus thuringiensis subsp. kurstaki, and the cloned gene was used to construct aprA-deleted (aprA1) strains of B. thuringiensis. An aprA1 strain of B. thuringiensis that contained the wild-type gene for neutral protease A (nprA(+)) displayed levels of extracellular proteolytic activity that were similar to those of an aprA(+)nprA(+) strain. However, when EDTA was included in the protease assay to inhibit NprA activity the aprA1nprA(+) strain displayed only 2% of the extracellular proteolytic activity of the aprA(+)nprA(+) strain. A strain that was deleted for both aprA and nprA (aprA1nprA3 strain) failed to produce detectable levels of proteolytic activity either in the presence or absence of EDTA in the assay. Compared with the aprA(+)nprA(+) strain the aprA1nprA(+) strain yielded 10% more full-length Cry1Bb crystal protein and the aprA1nprA3 strain yielded 25% more full-length Cry1Bb protein. No significant differences were seen in the 50% lethal dose of Cry1Bb protein from aprA(+)nprA(+) and aprA1nprA3 strains against three species of lepidopteran insects. These results suggest that enhanced yield of certain crystal proteins can be obtained by deletion of the genes aprA and nprA which are the major extracellular proteases of B. thuringiensis.

Development of the APR+ Auxiliary Building General Arrangement (GA)

International Nuclear Information System (INIS)

Moon, Hyung Keun; Park, Young Sheop; Kang, Yong Chul

2011-01-01

The general arrangement (GA) drawing of a nuclear power plant is the most basic drawing which contains all of the plant equipment, systems, and rooms. Therefore, it should be issued at an early design stage to provide the contours of the overall plant structure. This type of drawing is typically used widely throughout the design stages. The development project of APR+ (Advanced Power Reactor+), as a succeeding model of the APR1400 (Advanced Power Reactor 1400) design, has its own GA that encompasses all of its power buildings. This was developed starting in October of 2009. Among several of the buildings in this design, the Auxiliary Building (AB) is one of the most important buildings to produce electricity, and to protect against undesirable radiation emissions. This paper focuses on the design characteristics of the general arrangement of the AB

A Source Term Calculation for the APR1400 NSSS Auxiliary System Components Using the Modified SHIELD Code

International Nuclear Information System (INIS)

Park, Hong Sik; Kim, Min; Park, Seong Chan; Seo, Jong Tae; Kim, Eun Kee

2005-01-01

The SHIELD code has been used to calculate the source terms of NSSS Auxiliary System (comprising CVCS, SIS, and SCS) components of the OPR1000. Because the code had been developed based upon the SYSTEM80 design and the APR1400 NSSS Auxiliary System design is considerably changed from that of SYSTEM80 or OPR1000, the SHIELD code cannot be used directly for APR1400 radiation design. Thus the hand-calculation is needed for the portion of design changes using the results of the SHIELD code calculation. In this study, the SHIELD code is modified to incorporate the APR1400 design changes and the source term calculation is performed for the APR1400 NSSS Auxiliary System components

System Response Analysis of Rod Ejection Accident for APR1400 Using KNAP Hot Spot Model

International Nuclear Information System (INIS)

Kim, Yo-Han; Ha, Sang-Jun; Jun, Hwang-Yong

2006-01-01

Korea Electric Power Research Institute (KEPRI) has been developed the non-loss-of-coolant accident (non- LOCA) analysis methodology, called as the Korea Non- LOCA Analysis Package (KNAP), for the typical Optimized Power Reactor 1000 (OPR1000) plants. Considering current licensing methodology conducted by ABB-CE, however, the KNAP could be applied to Advanced Power Reactor 1400 (APR1400) also. In spite of some difference in design concepts of two plant types, there is a close resemblance between their nuclear steam supply systems (NSSS). So, in this study, the rod ejection accident (REA) event was analyzed using KNAP hot spot model (HSM) for APR1400 to estimate the feasibility of the application and the results were compared with those given in APR1400 Standard Safety Analysis Report (SSAR), which were calculated using the CESEC-III and STRIKIN-II code of ABB-CE. Through the study, it was concluded that the KNAP could be applicable to APR1400 on the view point of REA

Homology modeling of dissimilatory APS reductases (AprBA of sulfur-oxidizing and sulfate-reducing prokaryotes.

Directory of Open Access Journals (Sweden)

Birte Meyer

Full Text Available BACKGROUND: The dissimilatory adenosine-5'-phosphosulfate (APS reductase (cofactors flavin adenine dinucleotide, FAD, and two [4Fe-4S] centers catalyzes the transformation of APS to sulfite and AMP in sulfate-reducing prokaryotes (SRP; in sulfur-oxidizing bacteria (SOB it has been suggested to operate in the reverse direction. Recently, the three-dimensional structure of the Archaeoglobus fulgidus enzyme has been determined in different catalytically relevant states providing insights into its reaction cycle. METHODOLOGY/PRINCIPAL FINDINGS: Full-length AprBA sequences from 20 phylogenetically distinct SRP and SOB species were used for homology modeling. In general, the average accuracy of the calculated models was sufficiently good to allow a structural and functional comparison between the beta- and alpha-subunit structures (78.8-99.3% and 89.5-96.8% of the AprB and AprA main chain atoms, respectively, had root mean square deviations below 1 A with respect to the template structures. Besides their overall conformity, the SRP- and SOB-derived models revealed the existence of individual adaptations at the electron-transferring AprB protein surface presumably resulting from docking to different electron donor/acceptor proteins. These structural alterations correlated with the protein phylogeny (three major phylogenetic lineages: (1 SRP including LGT-affected Archaeoglobi and SOB of Apr lineage II, (2 crenarchaeal SRP Caldivirga and Pyrobaculum, and (3 SOB of the distinct Apr lineage I and the presence of potential APS reductase-interacting redox complexes. The almost identical protein matrices surrounding both [4Fe-4S] clusters, the FAD cofactor, the active site channel and center within the AprB/A models of SRP and SOB point to a highly similar catalytic process of APS reduction/sulfite oxidation independent of the metabolism type the APS reductase is involved in and the species it has been originated from. CONCLUSIONS: Based on the comparative

Constrained model predictive control for load-following operation of APR reactors

International Nuclear Information System (INIS)

Kim, Jae Hwan; Lee, Sim Won; Kim, Ju Hyun; Na, Man Gyun; Yu, Keuk Jong; Kim, Han Gon

2012-01-01

The load-following operation of APR+ reactor is needed to control the power effectively using the control rods and to restrain the reactivity control from using the boric acid for flexibility of plant operation. Usually, the reason why the disproportion of axial flux distribution occurs during load-following operation is xenon-induced oscillation. The xenon has a very high absorption cross-section and makes the impact on the reactor delayed by the iodine precursor. The power maneuvering using automatically load-following operation has advantage in terms of safety and economic operation of the reactor, so the controller has to be designed efficiently. Therefore, an advanced control method that meets the conditions such as automatic control, flexibility, safety, and convenience is necessary to load-following operation of APR+ reactor. In this paper, the constrained model predictive control (MPC) method is applied to design APR reactor's automatic load-following controller for the integrated thermal power level and axial shape index (ASI) control. Some controllers use only the current tracking command, but MPC considers future commands in addition to the current tracking command. So, MPC can achieve better tracking performance than others. Furthermore, an MPC is to used in many industrial process control systems. The basic concept of the MPC is to solve an optimization problem for a finite future time interval at present time and to implement the first optimal control input as the current control input. The KISPAC-1D code, which models the APR+ nuclear power plants, is interfaced to the proposed controller to verify the tracking performance of the reactor power level and ASI. It is known that the proposed controller exhibits very fast tracking responses

Implementation and Analysis for APR1400 Soft Control System

International Nuclear Information System (INIS)

2015-01-01

Due to the rapid advancement of digital technology, the definite technical advantages of digital control system compared to analog control system are accelerating the implementation of advanced distributed digital control system in the nuclear power plant. One of the major advantages of digital control system is the capability of Soft Control System. The design of Soft Control System for Advanced Power Reactor 1400 (APR1400) plant of Man-Machine Interface System (MMIS) is based on full digital technologies to enhance reliability, operability and maintainability. Computer-based compact workstation has been adopted in the APR1400 Main Control Room (MCR) to provide convenient working environment. This paper introduces the approaches and methodologies of Soft Control System for the Advanced Control Room (ACR). This paper also explains major design features for operation and display of the Soft Control System and its implementation to cope with regulatory requirements. (authors)

Verbal Communication in the APR1400 Advanced Control Room

International Nuclear Information System (INIS)

Kim, Jong Hyun; Shin, Young Cheol

2007-01-01

This paper introduces the characteristics of communication in advanced main controlghd rooms (MCRs) and some observations from a case study performed for APR1400 MCR. In advanced MCRs, operators need not maintain the same communication patterns as they do in conventional ones. For example, a senior reactor operator (SRO) does not have to rely on board operators for information acquisition and can get any information from his/her own workstation. This situation may also bring about new problems in MCRs such as lack of shared situation awareness and collaboration between MCR operators. To cope with these problems, the APR1400 MCR adapts several approaches in design and training for encouraging operators to communicate with each other. This paper introduces the possible changes of communication patterns and the countermeasures in design and training. Some findings from an integrated system validation for Shin Kori Units 3 and 4 are also presented

Vingt ans après…

Directory of Open Access Journals (Sweden)

François Burgat

2002-05-01

Full Text Available Le dixième numéro des Chroniques Yéménites, publié vingt ans après la création du Centre Français d'Archéologie et de Sciences Sociales de Sanaa reflète des ambitions souvent exprimées: donner une chance aux jeunes chercheurs et couvrir un large éventail disciplinaire au service de l'affirmation de la vocation régionale du Centre. Depuis Sanaa ou Paris, chercheurs, doctorants ou stagiaires, de l'Ecole normale supérieure, de l'INALCO, de l'Université de Sanaa et de bon nombre d'institu...

Seismic analysis of APR1400 RCS for site envelope using big mass method

International Nuclear Information System (INIS)

Kim, J. Y.; Jeon, J. H.; Lee, D. H.; Park, S. H.

2002-01-01

One of design concepts of APR1400 is the site envelope considering various soil sites as well as rock site. The KSNP's are constructed on the rock site where only the translational excitations are directly transferred to the plant. On the other hand, the rotational motions affect the responses of the structures in the soil cases. In this study, a Big Mass Method is used to consider rotational motions as excitations at the foundation in addition to translational ones to obtain seismic responses of the APR1400 RCS main components. The seismic analyses for the APR1400 excited simultaneously by translation and rotational motions were performed. The results show that the effect of soil sites is not significant for the design of main components and supports of the RCS, but it may be considerable for the design of reactor vessel internals, piping, and nozzles which have lower natural frequencies

Preliminary Design of Optimized Reactor Insulator for Severe Accident Mitigation of APR1400

International Nuclear Information System (INIS)

Heo, Sun; Lee, Jae-Gon; Kang, Yong-Chul

2007-01-01

APR1400, a Korean evolutionary advance light water reactor, has many advanced safety feature to prevent and mitigate of design basis accident (DBA) and severe accident. When reactor cooling system (RCS) fails to cooling its core, the core melted down and the molten core gathers together on bottom of reactor vessel. The molten core hurts reactor vessel and is released to containment, which raises the release of radioactive isotopes and the heating of the containment atmosphere. Finally, the corium is accumulated in the bottom of reactor cavity and it also raises the Molten Core and Concrete Interaction (MCCI) and the heating of containment atmosphere. There are two strategies to cooling molten core. Those are in-vessel retention and ex-vessel cooling. At the early stage of APR1400 design, only ex-vessel cooling which is cooling of the molten core outside the vessel after vessel failure is considered based on EPRI Utility Requirement Document (URD) for Evolutionary LWR. However, a need has been arisen to reflect current research findings on severe accident phenomena and mitigation technologies to Korean URD and IVRERVC (In-Vessel corium Retention using Ex-Reactor Vessel Cooling) was adopted APR1400. The ERVC is not considered as a licensing design basis but based on the defense-in-depth principle and safety margin basis, which is the top-tier requirement of the severe accident mitigation design as stated in the KURD. The Severe Accident Management strategy for APR1400 is intended to aid the plant operating staff to secure reactor vessel integrity in the early stage of the severe accident. As a part of a design implementation of IVR-ERVC for APR1400, we developed the preliminary design requirement, design specification and conceptual design

Single-tube condensation experiment in Passive Auxiliary Feedwater System of APR1400+

Energy Technology Data Exchange (ETDEWEB)

Shin, Chang Wook; No, Hee Cheon; Yun, Bong Yo; Jeon, Byong Guk [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

2012-05-15

Conventional Korean nuclear power plants, Advanced Power Reactors (APR), are characterized by an active cooling system. However, Active cooling system may not prevent significant damage without any AC power source available for its operation as vividly illustrated through the recent Fukushima incident. In the APR1400+ to be designed, an independent passive cooling system was added in order to overcome the aforementioned shortcomings. In the Passive Auxiliary Feedwater System (PAFS), gravity force and density difference between steam and water are used. The system comprises of 240 condensation tubes to efficiently remove decay heat. Before applying the PAFS to APR1400+, the system's safety and heat removal performance must be verified. The present study experimentally evaluates the heat removal performance of a single tube in the PAFS. The objectives of SCOP (Single-tube Condensation experiment facility of PAFS) are the evaluation of the heat removal performance in the tube of the PAFS and database construction under various tube designs and test conditions. Reaching these objectives, we developed advanced measurement techniques for the amount of moisture, heat flux, and water film thickness.

aprABC: A Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome

Science.gov (United States)

Abramovitch, Robert B.; Rohde, Kyle H.; Hsu, Fong-Fu; Russell, David G.

2011-01-01

Summary Following phagocytosis by macrophages, Mycobacterium tuberculosis (Mtb) senses the intracellular environment and remodels its gene expression for growth in the phagosome. We have identified an Acid and Phagosome Regulated (aprABC) locus that is unique to the Mtb complex and whose gene expression is induced during growth in acidic environments in vitro and in macrophages. Using the aprA promoter, we generated a strain that exhibits high levels of inducible fluorescence in response to growth in acidic medium in vitro and in macrophages. aprABC expression is dependent on the two-component regulator phoPR, linking phoPR signaling to pH sensing. Deletion of the aprABC locus causes defects in gene expression that impact aggregation, intracellular growth, and the relative levels of storage and cell wall lipids. We propose a model where phoPR senses the acidic pH of the phagosome and induces aprABC expression to fine-tune processes unique for intracellular adaptation of Mtb complex bacteria. PMID:21401735

Structural assessments of plate type support system for APR1400 reactor

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Anh Tung; Namgung, Ihn, E-mail: inamgung@kings.ac.kr

2017-04-01

Highlights: • This paper investigates plate-type support structure for the reactor vessel of the APR 1400. • The tall column supports of APR1400 reactor challenges in seismic and severe accident events. • A plate-type support of reactor vessel was proposed and evaluated based on ASME code. • The plate-type support was assessed to show its higher rigidity than column-type. - Abstract: This paper investigates an alternative form of support structure for the reactor vessel of the APR 1400. The current reactor vessel adopts a four-column support arrangement locating on the cold legs of the vessel. Although having been successfully designed, the tall column structure challenges in seismic events. In addition, for the mitigation of severe accident consequences, the columns inhibit ex-vessel coolant flow, hence the elimination of the support columns proposes extra safety advantages. A plate-type support was proposed and evaluated for the adequacy of meeting the structural stiffness by Finite Element Analysis (FEA) approach. ASME Boiler and Pressure Vessel Code was used to verify the design. The results, which cover thermal and static structural analysis, show stresses are within allowable limits in accordance with the design code. Even the heat conduction area is increased for the plate-type of support system, the results showed that the thermal stresses are within allowable limits. A comparison of natural frequencies and mode shapes for column support and plate-type support were presented as well which showed higher fundamental frequencies for the plate-type support system resulting in greater rigidity of the support system. From the outcome of this research, the plate-type support is proven to be an alternative to current APR column type support design.

Resultats visuels et complications apres chirurgie de la cataracte ...

African Journals Online (AJOL)

Resultats visuels et complications apres chirurgie de la cataracte: cas de l' Hopital Ophtalmologique Saint Andre de Tinre au nord-Benin. K.M. Amedome, C.R.A. Assavedo, M Aboudou, K Vonor, N Maneh, K Nonon Saa, K Dzidzinyo, K.D. Ayena, M Banla, K Balo ...

Le recours aux modeles dans l'enseignement de la biologie au secondaire : Conceptions d'enseignantes et d'enseignants et modes d'utilisation

Science.gov (United States)

Varlet, Madeleine

Le recours aux modeles et a la modelisation est mentionne dans la documentation scientifique comme un moyen de favoriser la mise en oeuvre de pratiques d'enseignement-apprentissage constructivistes pour pallier les difficultes d'apprentissage en sciences. L'etude prealable du rapport des enseignantes et des enseignants aux modeles et a la modelisation est alors pertinente pour comprendre leurs pratiques d'enseignement et identifier des elements dont la prise en compte dans les formations initiale et disciplinaire peut contribuer au developpement d'un enseignement constructiviste des sciences. Plusieurs recherches ont porte sur ces conceptions sans faire de distinction selon les matieres enseignees, telles la physique, la chimie ou la biologie, alors que les modeles ne sont pas forcement utilises ou compris de la meme maniere dans ces differentes disciplines. Notre recherche s'est interessee aux conceptions d'enseignantes et d'enseignants de biologie au secondaire au sujet des modeles scientifiques, de quelques formes de representations de ces modeles ainsi que de leurs modes d'utilisation en classe. Les resultats, que nous avons obtenus au moyen d'une serie d'entrevues semi-dirigees, indiquent que globalement leurs conceptions au sujet des modeles sont compatibles avec celle scientifiquement admise, mais varient quant aux formes de representations des modeles. L'examen de ces conceptions temoigne d'une connaissance limitee des modeles et variable selon la matiere enseignee. Le niveau d'etudes, la formation prealable, l'experience en enseignement et un possible cloisonnement des matieres pourraient expliquer les differentes conceptions identifiees. En outre, des difficultes temporelles, conceptuelles et techniques peuvent freiner leurs tentatives de modelisation avec les eleves. Toutefois, nos resultats accreditent l'hypothese que les conceptions des enseignantes et des enseignants eux-memes au sujet des modeles, de leurs formes de representation et de leur approche

Containment Performance Analysis with Large Break LOCA for EU-APR1400

International Nuclear Information System (INIS)

Hwang, Do Hyun; Lee, Keun Sung; Kim, Yong Soo

2013-01-01

In this paper for containment performance analysis, the containment pressurization analysis is performed and thermo-hydraulic response analysis of containment structure is carried out to provide basic understanding of containment transient states under a severe accident sequence. Especially, in EU-APR1400 design, to reduce containment pressure and temperature, Severe Accident Containment Spray System (SACSS) is designed to be actuated automatically when Core Exit Temperature (CET) reaches 922 K (649 .deg. C). The containment performance analysis was carried on LBLOCA sequence for EU-APR1400 with SACSS through MAAP code. If SACSS is actuated when CET reaches 922 K (649 .deg. C) , the containment pressure and temperature decrease to a sufficient low level. The predicted atmospheric pressure of containment will not exceed the ultimate pressure capacity (UPC) and have a sufficient margin to it even though the UPC of the reference plant (Shin-Kori Units 3 and 4) is used instead because the UPC calculation for EU-APR1400 has not been completed. The largest load on the containment by LBLOCA is estimated at 306.1 kPa. Thus the margin to UPC is estimated to be 330 % in comparison with 1.329 MPa as UPC for the reference plant.

MDEP Design-Specific Common Position CP-APR1400WG-01. Common position addressing Fukushima Daiichi nuclear power plant accident

International Nuclear Information System (INIS)

2016-05-01

The MDEP APR1400 Working Group (APR1400WG) members consist of members from Republic of Korea, United Arab Emirates, and the United States. A main objectives of MDEP is to encourage convergence of code, standard and safety goals with exploring the opportunities for harmonization of regulatory practice and cooperation on safety review of APR-1400 specific designs. This common position addressing is aimed at sharing knowledge, information and experience on safety improvement related to lessons learned from the Fukushima Daiichi NPP Accident or Fukushima Daiichi NPP Accident-related issues amongst APR-1400 WG member states to achieve the MEDP goal. Because not all of these Regulators have completed the regulatory review of their APR1400 applications yet, this paper identifies common preliminary approaches to address potential safety improvements for APR1400 plants, as well as common general expectations for new nuclear power plants, as related to lessons learned from the Fukushima Daiichi NPP Accident or Fukushima Daiichi NPP Accident-related issues. While some asymmetry exists among those of three Regulators in terms of design, regulatory practice and licensing milestone sharing information and common understanding on post-Fukushima Daiichi NPP Accident enhancement would be promote resilient design for countering beyond design extreme external event like Fukushima Daiichi NPP nuclear disaster. This common position paper aims at identifying characteristics of post-Fukushima Daiichi NPP Accident enhancements putting in place by each country and setting common position to achieve balanced and harmonized APR-1400 design. After the safety reviews of the APR1400 design applications that are currently in review are completed, the regulators will update this paper to reflect their safety conclusions regarding the APR1400 design and how the design could be enhanced to address Fukushima Daiichi NPP Accident-related issues. The common preliminary approaches are organised into

Uncertainty Evaluation of a Postulated LBLOCA for APR+ using KINS Realistic Evaluation Methodology and MARS-KS

Energy Technology Data Exchange (ETDEWEB)

Hwang, Min Jeong; Marigomena, Ralph; Yoo, Tae Ho; Kim, Y. S.; Sim, S. K. [Environment and Energy Technology, Inc., Daejeon (Korea, Republic of); Bang, Young Seok [KINS, Daejeon (Korea, Republic of)

2014-05-15

As a part of the regulatory safety research, Korea Institute of Nuclear Safety(KINS) also developed a best estimate safety analysis regulatory audit code, MARS-KS, to realistically predict and better understand the physical phenomena of the design basis accidents. KINS improved uncertainty propagation methodology using MARS-KS and applied the improved uncertainty evaluation method for the Shinkori Units 3 and 4 LBLOC. This study is to evaluate the uncertainty propagation of a postulated LBLOCA and quantify the safety margin using KINS-REM and MARS-KS code for the APR+ (Advanced Pressurizer Reactor Plus) Standard Safety Analysis Report(SSAR) which is under regulatory review by the KINS for its design approval. KINS-REM LBLOCA realistic evaluation methodology was used for the regulatory assessment of the APR+ LBLOCA using MARS-KS to evaluate the uncertainty propagation of the uncertainty variables as well as to assess the safety margin during the limiting case of the APR+ double ended guillotine cold leg LBLOCA. Uncertainty evaluation for the APR+ LBLOCA shows that the reflood PCT with upper limit of 95% probability at 95% confidence level is 1363.2 K and is higher than the blowdown PCT95/95 of 1275.3 K. The result shows that the current evaluation of APR+ LBLOCA PCT is within the acceptance criteria of 1477 K ECCS.

[Evaluation of the capacity of the APR-DRG classification system to predict hospital mortality].

Science.gov (United States)

De Marco, Maria Francesca; Lorenzoni, Luca; Addari, Piero; Nante, Nicola

2002-01-01

Inpatient mortality has increasingly been used as an hospital outcome measure. Comparing mortality rates across hospitals requires adjustment for patient risks before making inferences about quality of care based on patient outcomes. Therefore it is essential to dispose of well performing severity measures. The aim of this study is to evaluate the ability of the All Patient Refined DRG system to predict inpatient mortality for congestive heart failure, myocardial infarction, pneumonia and ischemic stroke. Administrative records were used in this analysis. We used two statistics methods to assess the ability of the APR-DRG to predict mortality: the area under the receiver operating characteristics curve (referred to as the c-statistic) and the Hosmer-Lemeshow test. The database for the study included 19,212 discharges for stroke, pneumonia, myocardial infarction and congestive heart failure from fifteen hospital participating in the Italian APR-DRG Project. A multivariate analysis was performed to predict mortality for each condition in study using age, sex and APR-DRG risk mortality subclass as independent variables. Inpatient mortality rate ranges from 9.7% (pneumonia) to 16.7% (stroke). Model discrimination, calculated using the c-statistic, was 0.91 for myocardial infarction, 0.68 for stroke, 0.78 for pneumonia and 0.71 for congestive heart failure. The model calibration assessed using the Hosmer-Leme-show test was quite good. The performance of the APR-DRG scheme when used on Italian hospital activity records is similar to that reported in literature and it seems to improve by adding age and sex to the model. The APR-DRG system does not completely capture the effects of these variables. In some cases, the better performance might be due to the inclusion of specific complications in the risk-of-mortality subclass assignment.

Design of a Load Following Controller for APR+ Nuclear Plants

International Nuclear Information System (INIS)

Lee, Sim Won; Kim, Jae Hwan; Kim, Dong Su; Na, Man Gyun; Yu, Keuk Jong

2011-01-01

The load-following operation of an APR+ nuclear plants is required to restrain the adjustment of boric acid concentration and to efficiently control the control rods for the flexibility of the operation. Especially, axial flux distribution disproportion that is usually caused by load-following operation in a reactor core induces xenon oscillation because the absorption cross-section of xenon is extremely large and its effects in a reactor are delayed by the iodine precursor. Rapid and smooth power maneuvering has its benefits in view of the economical and safe operation of reactors, so it is required that the controller is efficiently designed. Therefore, the load-following operation of an APR+ nuclear plants needs the ultimate automatic control and the advanced control method that satisfies the conditions such as the flexibility, safety and convenience. A model predictive control (MPC) method is applied to design an automatic load-following controller for the integrated thermal power level and axial shape index (ASI) control for an APR+ nuclear plants. Some tracking controllers use only the current tracking command. On the other hand, since MPC considers future commands in addition to the current tracking command, the MPC can achieve better tracking performance. Therefore, the MPC has been applied very much to the control of industrial process systems. The basic concept of the MPC is to solve an optimization problem for generating finite future control inputs at current time and to implement as the current control input only the first control input among the solutions of the finite time steps. At the next time step, the second control input is not implemented and the procedure to solve the optimization problem is then repeated. The power level and the ASI are controlled by the regulating control banks and part-strength control banks together with the automatic adjustment of boric acid concentration. The 3-dimensional MASTER code, which models the APR+ nuclear

Design of a Load Following Controller for APR+ Nuclear Plants

Energy Technology Data Exchange (ETDEWEB)

Lee, Sim Won; Kim, Jae Hwan; Kim, Dong Su; Na, Man Gyun [Chosun University, Gwnagju (Korea, Republic of); Yu, Keuk Jong [Korea Hydro and Nuclear Power Co., Daejeon (Korea, Republic of)

2011-08-15

The load-following operation of an APR+ nuclear plants is required to restrain the adjustment of boric acid concentration and to efficiently control the control rods for the flexibility of the operation. Especially, axial flux distribution disproportion that is usually caused by load-following operation in a reactor core induces xenon oscillation because the absorption cross-section of xenon is extremely large and its effects in a reactor are delayed by the iodine precursor. Rapid and smooth power maneuvering has its benefits in view of the economical and safe operation of reactors, so it is required that the controller is efficiently designed. Therefore, the load-following operation of an APR+ nuclear plants needs the ultimate automatic control and the advanced control method that satisfies the conditions such as the flexibility, safety and convenience. A model predictive control (MPC) method is applied to design an automatic load-following controller for the integrated thermal power level and axial shape index (ASI) control for an APR+ nuclear plants. Some tracking controllers use only the current tracking command. On the other hand, since MPC considers future commands in addition to the current tracking command, the MPC can achieve better tracking performance. Therefore, the MPC has been applied very much to the control of industrial process systems. The basic concept of the MPC is to solve an optimization problem for generating finite future control inputs at current time and to implement as the current control input only the first control input among the solutions of the finite time steps. At the next time step, the second control input is not implemented and the procedure to solve the optimization problem is then repeated. The power level and the ASI are controlled by the regulating control banks and part-strength control banks together with the automatic adjustment of boric acid concentration. The 3-dimensional MASTER code, which models the APR+ nuclear

The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study: rationale and methods.

Science.gov (United States)

Kaplan, Bonnie J; Giesbrecht, Gerald F; Leung, Brenda M Y; Field, Catherine J; Dewey, Deborah; Bell, Rhonda C; Manca, Donna P; O'Beirne, Maeve; Johnston, David W; Pop, Victor J; Singhal, Nalini; Gagnon, Lisa; Bernier, Francois P; Eliasziw, Misha; McCargar, Linda J; Kooistra, Libbe; Farmer, Anna; Cantell, Marja; Goonewardene, Laki; Casey, Linda M; Letourneau, Nicole; Martin, Jonathan W

2014-01-01

The Alberta Pregnancy Outcomes and Nutrition (APrON) study is an ongoing prospective cohort study that recruits pregnant women early in pregnancy and, as of 2012, is following up their infants to 3 years of age. It has currently enrolled approximately 5000 Canadians (2000 pregnant women, their offspring and many of their partners). The primary aims of the APrON study were to determine the relationships between maternal nutrient intake and status, before, during and after gestation, and (1) maternal mood; (2) birth and obstetric outcomes; and (3) infant neurodevelopment. We have collected comprehensive maternal nutrition, anthropometric, biological and mental health data at multiple points in the pregnancy and the post-partum period, as well as obstetrical, birth, health and neurodevelopmental outcomes of these pregnancies. The study continues to follow the infants through to 36 months of age. The current report describes the study design and methods, and findings of some pilot work. The APrON study is a significant resource with opportunities for collaboration. © 2012 John Wiley & Sons Ltd.

Veselības aprūpes iemaņas pusaudžiem bērnu namā

OpenAIRE

Zūpe, Daira

2008-01-01

Pētniecības darbā „Veselības aprūpes iemaņas pusaudžiem bērnu namā” autore Daira Zūpe izpēta un analizē vienu no bērnu namu aktuālajām problēmām veselības profilakses veicināšanā – veselības aprūpes iemaņu attīstīšanu. Pētījumā uzmanība pievērsta māsas lomai bērnu nama pusaudžu veselības aprūpes procesā, kur akcentēta veselības aprūpes pamatiemaņu nozīme veselības vecināšanā - fiziskās aktivitātes, ēšanas paradumi, kaitīgie ieradumi un higiēnas iemaņas. Pētniecības darba zinātniskā vadītā...

Aprūpes īpatnības bērniem ar Dauna sindromu stacionārā

OpenAIRE

Lūse, Ērika

2015-01-01

Bakalaura darba tēma – Aprūpes īpatnības bērniem ar Dauna sindromu stacionārā. Tēmas aktualitāte pievērst uzmanību bērna ar Dauna sindroma aprūpei, kā arī mazināt stereotipus par šiem bērniem. Darba mērķis ir izpētīt Dauna sindromu un māsas lomu šo bērnu aprūpē, kā arī aprūpes īpatnības. Pētniecības uzdevumi ir veikt zinātniskās literatūras analīzi, pētījuma atbilstošas māszinību teorijas atlasi, izstrādāt anketu, veikt pilot pētījumu, iegūto datu apkopošanu, analīze un secinājumu veikšana. I...

APR1400 Electrical Power System Conformance to SECY-91-078

Energy Technology Data Exchange (ETDEWEB)

Ha, Che-Wung; Kim, Yun-Ho [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

In this paper, the APR1400 electric power system for NRC-DC was described. In addition, the conformance to SECY 91-078 was evaluated. Enclosure 1 of the SECY provides an overview of the issue and states that the staff concludes that feeding the safety buses from the offsite power sources through non-safety buses or from a common transformer winding with non-safety loads is not the most reliable configuration. Such an arrangement increases the difficulty in properly regulating voltage at the safety buses, subjects the safety loads to transients caused by the non-safety loads, and adds additional failure points between the offsite power sources and safety loads. Therefore, it is the staff’s position that at least one offsite circuit to each redundant safety division should be supplied directly from one of the offsite power sources with no intervening non-safety buses, in such a manner that the offsite source can power the safety buses upon a failure of any non-safety bus. The APR1400 does not have an intervening nonsafety bus in the current offsite to onsite electrical configuration; however, the design does include nonsafety and safety buses coming from the same secondary side 4.16 kV transformer winding. Nevertheless, the APR1400 has designed the electrical interface system between offsite and onsite power with enhanced reliability measures to ensure that the nonsafety system will not impact the safety loads. The design complies with GDC 17 and also conforms to SECY-91-078.

Quality Control of Concrete Structure For APR1400 Construction

International Nuclear Information System (INIS)

Seo, Inseop; Song, Changhak; Kim, Duill

2012-01-01

Nuclear structure shall be constructed to protect internal facilities in the normal operation against external accidents such as the radiation shielding, earthquakes and to be leak-proof of radioactive substances to the external environment in case of loss of coolants. containment and auxiliary building of nuclear power plants are built in reinforced concrete structures to maintain these protection functions. Nuclear structures shall be designed to ensure soundness in operation since they are located on the waterfront where is easy do drain the cooling water and so deterioration and damage of concrete structures caused by seawater can occur. Durability is ensured for concrete structures of APR1400, a Korea standard NPP, in compliance with all safety requirements. In particular, owners perform quality control directly on the production and pouring of cast in place concrete for the concrete structure construction to make sure concrete structures established with quality homogeneity and durability. This report is to look into the quality control standard and management status of cast in place concrete for APR1400 construction

Study on Applicability of 10 CFR Part 21 to APR1400 DC Project

International Nuclear Information System (INIS)

Shin, He Young; Lee, Do Hwan; Lim, Jae Yong

2014-01-01

The tools such as NCR (non conformance report), CAR (corrective action request) and CAP (corrective action program) are widely used for that purpose based upon the rule of 10 CFR Part 50 Appendix B and the ASME Code NQA-1 requirements. These are the tools for a utility, as a purchaser taking over related basic components and services, to ensure strong quality assurance. During the conduct of the project for the acquisition of the standard design certification for APR1400 nuclear power plants from the U. S. NRC (APR1400 DC Project), a new CAP procedure that is appropriate to conduct this unique project was developed. However, it was also recommended to comply with the requirements under 10 CFR Part 21 which enhances nuclear safety quality assurances. Consequently, a new QA procedure is developed in order to deal with the 10 CFR Part 21 issues and this is integrated to the CAP procedure In this paper, the current corrective action program for the APR1400 DC project is introduced and the result of the study on the applicability of 10 CFR Part 21 to the project is indicated. In addition, further improving aspects to be considered are identified. As a frontier project to obtain the standard design certification for APR 1400 model from the U. S. NRC, a modified CAP procedure is developed and enhanced to deal with safety concerning issues in accordance with 10 CFR Part 21. In addition, the newly established QA procedure to directly control the reportability on 10 CFR Part 21 is interfaced into the existing CAP procedure

Utilisation de données secondaires et signature scientifique lors de l'évaluation d'une intervention en santé mondiale

Directory of Open Access Journals (Sweden)

Valéry Ridde

2018-03-01

Full Text Available Dans le domaine de la santé mondiale, les bailleurs de fonds internationaux financent de nombreuses interventions dont ils souhaitent l'efficacité. Ils financent ainsi parfois des évaluations externes, le plus souvent menées par des chercheurs du Nord, pour en faire la démonstration. En outre, il existe de multiples bases de données, souvent collectées par les chercheurs du Sud, utiles pour réaliser ce type d'études. Mais cette multiplicité d'acteurs, de collaboration, d'enjeux et de potentiels conflits d'intérêts pose des défis importants sur le plan de l'utilisation de données secondaires et de la signature scientifiques des publications qui peuvent en découler. Cette étude de cas propose une réflexion à cet égard.

Assistant Personal Robot (APR: Conception and Application of a Tele-Operated Assisted Living Robot

Directory of Open Access Journals (Sweden)

Eduard Clotet

2016-04-01

Full Text Available This paper presents the technical description, mechanical design, electronic components, software implementation and possible applications of a tele-operated mobile robot designed as an assisted living tool. This robotic concept has been named Assistant Personal Robot (or APR for short and has been designed as a remotely telecontrolled robotic platform built to provide social and assistive services to elderly people and those with impaired mobility. The APR features a fast high-mobility motion system adapted for tele-operation in plain indoor areas, which incorporates a high-priority collision avoidance procedure. This paper presents the mechanical architecture, electrical fundaments and software implementation required in order to develop the main functionalities of an assistive robot. The APR uses a tablet in order to implement the basic peer-to-peer videoconference and tele-operation control combined with a tactile graphic user interface. The paper also presents the development of some applications proposed in the framework of an assisted living robot.

Study of secondary electronic emission in some piezo-electric materials: application to ultrasonic visualization; Etude de l'emission electronique secondaire de quelques materiaux piezoelectriques: application a la visualisation ultrasonore

Energy Technology Data Exchange (ETDEWEB)

Marini, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

Methods allowing the visualization of acoustic images appear at the moment to be of great interest in the field of non-destructive testing as well as in that of underwater detection. In order to carry out certain calculations on the operation of an ultrasonic camera, it has been necessary to study the secondary electron emission of some piezoelectric materials liable to be incorporated into the equipment. The secondary electron emission of insulators is a rather complex phenomenon; in order to find a rational explanation for the observations made, a theory has been developed for the energy spectrum of the emitted electrons. The experimental results of this work have then been used to build an ultrasonic visualization installation. Some examples of acoustic images which have been visualized are also presented. (author) [French] Les methodes qui permettent de visualiser des images acoustiques trouvent a l'heure actuelle un grand interet dans le domaine du controle non destructif comme dans celui de la detection sous-marine. De maniere a effectuer certains calculs sur le fonctionnement d'une camera ultrasons, il a ete necessaire d'etudier l'emission electronique secondaire de quelques materiaux piezoelectriques susceptibles d'etre utilises dans sa construction. L'emission electronique secondaire des isolants est un phenomene assez complexe et de maniere a trouver des explications coherentes aux observations effectuees, une theorie du spectre energetique des electrons emis a ete elaboree. Une installation de visualisation ultrasonore a alors ete realisee a partir des donnees experimentales de cette etude. Quelques exemples d'images acoustiques visualisees par cette methode sont egalement presentees. (auteur)

Apreçando Derivativos de Crédito no Brasil Credit Derivatives Pricing in Brazil

Directory of Open Access Journals (Sweden)

Jorge C. Kapotas

2004-12-01

Full Text Available Neste artigo apresentamos os principais modelos de apreçamento de instrumentos de crédito onde desenvolvem-se as equações de apreçamento de debêntures. Para tal, utilizam-se os modelos estruturais, de intensidade e, finalmente, de rating. A seguir, definimos o que são derivativos de crédito (CDS e derivamos fórmulas de apreçamento para estes instrumentos. Concluímos este artigo com uma aplicação ao mercado brasileiro. In this paper we present the main models used for pricing defaultable bonds and credit derivatives. The Merton structural model, the intensity framework and a Ratings based model are considered. We apply these techniques to the pricing of credit derivatives on Brazilian US$-indexed treasury bonds.

Scanning in Thyroid Cancer; Exploration des tumeurs de la thyroide; Ispol'zovanie radioizotopov pri issledovanii raka shchitovidnoj zhelezy; Exploracion de los tumores tiroideos

Energy Technology Data Exchange (ETDEWEB)

Bauer, Franz K [Radioisotope Centre, University of Southern California School of Medicine, Los Angeles, CA (United States)

1959-07-01

Scanning in thyroid cancer is of value in - 1. The preoperative diagnosis of a thyroid nodule; 2. The localization of thyroid cancer metastases; 3. The treatment of thyroidectomize d patients with metastases from thyroid cancer. The appearance of thyroid nodules on the scintigram is described. Some prelimi- nary results of the use of radiophosphoru s and external counting with a Geiger- Mueller tube of ''cold'' nodules are reported. Localization of thyroid cancer metastases with particular emphasis on the use of thyrotropic hormone is described. With this method three-fourths of all patients with metastatic thyroid cancer were found to have functioning metastases. The technique of ablation of normal thyroid remnants following total thyroidectomy and the treatment of metastases is discussed in detail. Scanning of metastases is the best method to follow the patient's progress. (author) [French] L'exploration des tumeurs de la thyroide presente un interet pour: 1. Le diagnostic preoperatoire des nodules de la thyroide; 2. La localisation des metastases du cancer de la thyroide; 3. Le traitement des personnes ayant subi l'ablation de la thyroide et atteintes de metastases du cancer de la thyroide. L'auteur decrit l'aspect des nodules de la thyroide sur le scintigramme. Il donne certains resultats preliminaires obtenus par l'emploi du radiophosphore et par comptage externe des nodules < froids > a l'aide d'un tube de Geiger-Mueller. L'auteur etudie aussi la localisation des metastases du cancer de la thyroide, en particulier par l'utilisation de l'hormone thyrotropique. L'emploi de cette methode a permis de constater que les trois quarts des malades atteints de cancer metastatique de la thyroide souffraient de metastases en activite. Apres avoir evoque la thyroidectomie totale et la methode d'ablation des fragments de thyroide restant normalement apres operation, l'auteur etudie en detail le traitement des metastases. L'exploration des metastases est la meilleure

Écrire (d’après

Directory of Open Access Journals (Sweden)

Denis Saint-Amand

2009-03-01

Full Text Available De l’allusion à la citation, de l’emprunt criard au plagiat déguisé, les jeux d’influences et d’aller-retour avec tel ou tel modèle, grand ou mineur, ont toujours participé de l’élaboration du texte littéraire. Si l’intertextualité est sans aucun doute née en même temps que l’écriture (ou quelques minutes après et que, comme ont pu le montrer notamment Jacques-Philippe Saint-Gérand et Daniel Sangsue, les facettes multiples qu’elle déploie ont toujours suscité l’attention des hommes de lettre...

New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74.

Science.gov (United States)

Pearson, Mark S; Jariwala, Amar R; Abbenante, Giovanni; Plieskatt, Jordan; Wilson, David; Bottazzi, Maria Elena; Hotez, Peter J; Keegan, Brian; Bethony, Jeffrey M; Loukas, Alex

2015-01-01

Na-APR-1(M74) is an aspartic protease that is rendered enzymatically inactive by site-directed mutagenesis and is a candidate antigen component in the Human Hookworm Vaccine. The mutant protease exerts vaccine efficacy by inducing antibodies that neutralize the enzymatic activity of wild type enzyme (Na-APR-1wt) in the gut of the hookworm, thereby depriving the worm of its ability to digest its blood meal. Previously, canines immunized with Na-APR-1(M74) and challenged with Ancylostoma caninum were partially protected against hookworm challenge infection, especially from the loss in hemoglobin observed in control canines and canine immunoglobulin (Ig) G raised against Na-APR-1 was shown to inhibit the enzymatic activity of Na-APR-1 wt in vitro, thereby providing proof of concept of Na-APR-1(M74) as a vaccine antigen. The mutated version, Na-APR-1(M74), was then expressed at the cGMP level using a Nicotiana benthamiana expression system (Fraunhofer, CMB, Delaware, MD), formulated with Alhydrogel®, and used to immunize mice in a dose-ranging study to explore the enzyme-neutralizing capacity of the resulting anti- Na-APR-1(M74) IgG. As little as 0.99 μg of recombinant Na-APR-1(M74) could induce anti Na-APR-1(M74) IgG in mice that were capable of inhibiting Na-APR-1w t-mediated digestion of a peptide substrate by 89%. In the absence of enzymatic activity of Na-APR-1(M74) as a surrogate marker of protein functionality, we developed an assay based on the binding of a quenched fluorescence-labeled inhibitor of aspartic proteases, BODIPY-FL pepstatin A (BDP). Binding of BDP in the active site of Na-APR-1 wt was demonstrated by inhibition of enzymatic activity, and competitive binding with unlabelled pepstatin A. BDP also bound to Na-APR-1(M74) which was assessed by fluorescence polarization, but with an ∼ 50-fold reduction in the dissociation constant. Taken together, these assays comprise a "toolbox" that could be useful for the analyses of Na-APR-1(M74) as it

Analytical Assessment of Environmental Impact for APR1400DC UHS Cooling Tower

Energy Technology Data Exchange (ETDEWEB)

Lee, Jaiho [KHNP-Central Research Institute, Daejeon (Korea, Republic of)

2015-05-15

Hot process water is pumped from the plant process to the cooling towers. Heat is rejected through evaporation of the process water, interacting with ambient air blown upward by fans.. Plumes generated from exit ports of the cooling tower may have adverse effects on the environment, such as deposition of cooling tower drift release, fogging, icing, shadowing, and ground-level temperature and humidity increase. These kinds of environmental impact of the cooling tower are linked closely with the dispersion of the cooling tower plumes. In this respect, predicting the behavior of the plumes has become one of the most important issues in the environmental assessments of the cooling towers. The SACTI (seasonal/annual cooling tower impact) model is an analytical tool to predict the environmental effect of cooling tower, which was developed by Argonne National Laboratory and University of Illinois with support from EPRI (electric power research institute). The initial version of SACTI has been widely used to assess the environmental effect of cooling towers in many industrial fields such as steam power plants and NPPs. Guo et. al. investigated impact of heat rejection and cooling tower height on plume dispersion using the SACTI model, for the purpose of the future construction of inland NPPs. They found that increasing cooling tower height decreases the plume length and height frequencies. Their simulation results showed that the increase in heat rejection increases the plum radius frequency. The APR1400DC is an advanced light water reactor developed for the purpose of NRC-DC (design certification). The cooling towers for APR1400DC UHS consist of two linear mechanical draft cooling towers (LMDCTs). The LMDCT for APR1400DC UHS is conceptually designed because the plant site has not been decided yet. In the present study, the dependency of plume dispersion on the number of cooling towers is investigated using SACTI-2-beta, for predicting annual environmental effect of APR

Applications of Qualitative Microanalysis to the Determination of Secondary Species Associated with Uranium; Application de la microanalyse qualitative a la determination des especes secondaires d'uranium

Energy Technology Data Exchange (ETDEWEB)

Agrinier, H

1959-02-01

Microanalytical techniques are described which allow rapid determinations of secondary species associated with uranium. They consist in exposing the constituent elements of the ores by means of characteristic microchemical reactions. Because of their rapidity and the small amount of apparatus needed, these techniques can be used either in the field or in the laboratory. (author) [French] Les techniques de microanalyse decrites dans cet ouvrage permettent la determination rapide des especes secondaires d'uranium. Elles consistent a mettre en evidence les elements constitutifs des mineraux par des reactions microchimiques caracteristiques. En raison de leur rapidite et du peu de materiel qu'elles necessitent, ces techniques peuvent etre utilisees aussi bien sur le terrain qu'au laboratoire. (auteur)

Effectiveness of External Reactor Vessel Cooling (ERVC) strategy for APR1400 and issues of phenomenological uncertainties

International Nuclear Information System (INIS)

Oh, S.J.; Kim, H.T.

2007-01-01

The APR1400(Advanced Power Reactor 1400) is an evolutionary advanced light water reactor with rated thermal power of 4000 MWt. For APR1400, External Reactor Vessel Cooling (ERVC) is adopted as a primary severe accident management strategy for in-vessel retention (IVR) of corium. The ERVC is a method of IVR by submerging the reactor vessel exterior. At the early stage of the APR1400 design, only ex-vessel cooling, cooling of the core melt outside the vessel after vessel is breached, is considered based on the EPRI Utility Requirement Document for Evolutionary LWR. However, based on the progress in implementation of Severe Accident Management Guidance (SAMG) for operating plants, as well as the research findings related to ERVC, ERVC strategy is adopted as a part of key severe accident management strategies. To improve its success, the strategy is reviewed and we implemented necessary design arrangement to increase its usefulness in managing the severe accident. In this paper, we examine the evolution of ERVC concept and its implementation in APR1400. Then, we review possible approach, including Risk-Oriented Accident Analysis Methodology (ROAAM), to evaluate the effectiveness of the strategy. (authors)

897.pdf | apr102004 | currsci | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; currsci; apr102004; 897.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

Implementasi Automatic Packet Reporting System (APRS Untuk Paket Data Pemantauan dan PengukuranUntuk Paket Data Pemantauan dan Pengukuran

Directory of Open Access Journals (Sweden)

Arief Goeritno

2016-03-01

Full Text Available Telah dilakukan implementasi Automatic Packet Reporting System (APRS untuk paket data pemantauan dan pengukuran melalui tujuan penelitian, berupa: a penyetelan program aplikasi pada jaringan APRS dan b pengukuran terhadap penerimaan data berdasarkan kinerja sensor-sensor. Penyetelan program aplikasi APRS merupakan konfigurasi perangkat lunak untuk APRS yang akan digunakan pada stasiun penerimaan data APRS dengan program aplikasi yang biasa digunakan, yaitu hyperterminal dan UI-View 32. Pengukuran penerimaan data berdasarkan kinerja sensor yang dilakukan melalui proses perekaman pada stasiun penerimaan data APRS. Kinerja sensor-sensor akan diamati pada stasiun pengiriman dan data hasil pengamatan akan dapat diterima pada stasiun penerimaan secara real time. Program aplikasi berbasis hyperterminal dan UI View 32 telah berhasil melakukan proses handshaking antara Terminal Node Controller (TNC dan komputer, sehingga data telemetri dari stasiun pengiriman paket data dapat diterima di stasiun penerimaan. Data telemetri dapat diamati pada stasiun penerimaan dan dapat diperoleh secara real time dengan format: YB0LRB-11>BEACON,WIDE2-1 [05/18/2014 04:03:49]: : T#010,008,093,004,122,075. Notifikasi YB0LRB-11 merupakan stasiun pengiriman paket data telemetri, kemudian data tersebut akan diterima pada stasiun penerima YD1PRY dengan format: YD1PRY-2>APLPN,ARISS [05/18/2014 04:03:07]: : !06.30.37S/106.48.26E#. Notifikasi tersebut merupakan pengiriman informasi data posisi oleh stasiun YD1PRY untuk inisialisasi pada jaringan APRS. Stasiun YB0LRB-11 ketika mengirim paket data telemetri dengan format: YB0LRB-11>BEACON,WIDE2-1 [05/18/2014 04:00:49]: : T#001,004,035,005,122,075. Paket data dari stasiun YB0LRB yang dipancar ulang atau digipeater dengan format: YB0LRB-11>BEACON,YD1PRY-2,WIDE2* [05/18/2014 04:00:50]: : T#001,004,035,005,122,075. Sensor pengukuran berkinerja relatif stabil, walaupun terdapat nilai simpangan pengukuran sebesar 1 cm atau

75 FR 44847 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

Science.gov (United States)

2010-07-29

... 943, 943-PR, 943- A, and 943A-PR AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... comments concerning Forms 943, Employer's Annual Tax Return for Agricultural Employees, 943-PR, Planilla..., Agricultural Employer's Record of Federal Tax Liability, and 943A-PR, Registro De La Obligacion Contributiva...

Numerical Analysis of Molten Corium Dispersion during Hypothetical High-Pressure Accidents in APR1400 Nuclear Power Plant

International Nuclear Information System (INIS)

Kim, Jong Tae; Ha, Kwang Soon; Kim, Sang Baik; Kim, Hee Dong; Jeong, Jae Sik

2010-01-01

During a hypothetical high-pressure accident in a nuclear power plant (NPP), molten corium can be ejected through a breach of a reactor pressure vessel (RPV) and dispersed by the following jet of a high pressure steam in the RPV. The dispersed corium is fragmented into smaller droplets in a reactor cavity of the NPP by the steam jet with very high velocity and is released into the upper compartment of the NPP by an overpressure in the cavity. The heat-carrying fragments of the corium transfer the thermal energy to the ambient air in the containment and react chemically with steam and generate hydrogen which may be burnt in the containment. The thermal loads from the ejected molten corium on the containment which is called direct containment heating (DCH) can threaten the integrity of the containment. New generation NPPs such as APR1400 and EPR have been designed in consideration of reducing the possibility of the containment failure from the DCH. In order for that, APR1400 has a convolute-type corium chamber connected to the reactor cavity. In the case of EPR, severe-accident dedicated depressurization valves are installed to preclude a high pressure melt ejection (HPME). DCH in a NPP containment is related to many physical phenomena such as multi-phase hydrodynamics, thermodynamics and chemical reaction. In the evaluation of the DCH load, the melt dispersion rates depending on the RPV pressure are the most important parameter. Mostly, DCH was evaluated by using lumped-analysis codes with some correlations obtained from experiments for the dispersion rates. The corium dispersion rates for many types of the NPP containments had been obtained by experiments in 90s. And some correlations from the experimental data were developed. As mentioned above, APR1400 has a corium chamber to reduce the corium dispersion rate. But there is no experimental data for the dispersion rate specific to the APR1400 cavity geometry. So its performance for capturing of the dispersed corium

78 FR 47051 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

Science.gov (United States)

2013-08-02

... 943, 943-PR, 943- A, and 943A-PR AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and..., 943-PR, Planilla Para La Declarcion Anual De La Contribucion Federal Del Patrono De Empleados Agricolas, 943-A, Agricultural Employer's Record of Federal Tax Liability, and 943A-PR, Registro De La...

An Experimental Investigation on APR1400 Penetration Weld Failure by Metallic Melt

International Nuclear Information System (INIS)

An, Sang Mo; Ha, Kwang Soon; Kim, Hwan Yeol

2014-01-01

The penetrations are considered as the most vulnerable parts with respect to the reactor vessel failure when a core melt severe accident occurs and the corium reaches the lower head. Penetration tube failure modes can be divided into two categories; tube ejection out of the vessel lower head and rupture of the penetration tube outside the vessel. Tube ejection begins with degrading the penetration tube weld strength to zero as the weld is exposed to temperatures as high as the weld melting temperature, which is called weld failure, and then overcoming any binding force in the hole in the vessel wall that results from differential thermal expansion of the tube and vessel wall. Tube rupture assumes that the debris bed has melted the instrument tube inside the reactor and melt migrates down into the tube to a location outside the vessel wall where a pressure rupture can occur, thus breaching the pressure boundary. In the present paper, we have a focus on the tube ejection failure mode, specifically on the APR1400 weld failure by direct contact with a metallic melt. The objective is to investigate experimentally the ablation kinetics of an APR1400 penetration weld during the interactions with a metallic melt and to suggest the modification of the existing weld failure model. This paper involves the interaction experiments of two different metallic melts (metallic corium and stainless steel melts) with a weld specimen, and rough estimation of weld failure time. The interaction experiments between the metallic melts and an APR1400 penetration weld were performed to investigate the ablation kinetics of the penetration weld. Metallic corium and stainless steel melts were generated using an induction heating technique and interacted with a penetration weld specimen. The ablation rate of the weld specimen showed a range from 0.109 to 0..244 mm/s and thus the APR1400 penetration weld was estimated to be failed at hundreds of times after the interaction with the melt

Development of a Test Facility to Simulate the Reactor Flow Distribution of APR+

International Nuclear Information System (INIS)

Euh, D. J.; Cho, S.; Youn, Y. J.; Kim, J. T.; Kang, H. S.; Kwon, T. S.

2011-01-01

Recently a design of new reactor, APR+, is being developed, as an advanced type of APR1400. In order to analyze the thermal margin and hydraulic characteristics of APR+, quantification tests for flow and pressure distribution with a conservation of flow geometry are necessary. Hetsroni (1967) proposed four principal parameters for a hydraulic model representing a nuclear reactor prototype: geometry, relative roughness, Reynolds number, and Euler number. He concluded that the Euler number should be similar in the prototype and model under the preservation of the aspect ratio on the flow path. The effect of the Reynolds number at its higher values on the Euler number is rather small, since the dependency of the form and frictional loss coefficients on the Reynolds number is seen to be small. ABB-CE has carried out several reactor flow model test programs, mostly for its prototype reactors. A series of tests were conducted using a 3/16 scale reactor model. (see Lee et al., 2001). Lee et al (1991) performed experimental studies using a 1/5.03 scale reactor flow model of Yonggwang nuclear units 3 and 4. They showed that the measured data met the acceptance criteria and were suitable for their intended use in terms of performance and safety analyses. The design of current test facility was based on the conservation of Euler number which is a ratio of pressure drop to dynamic pressure with a sufficiently turbulent region having a high Reynolds number. By referring to the previous study, the APR+ design is linearly reduced to 1/5 ratio with a 1/2 of the velocity scale, which yields a 1/39.7 of Reynolds number scaling ratio. In the present study, the design feature of the facilities, named 'ACOP', in order to investigate flow and pressure distribution are described

Critical heat flux for APR1400 lower head vessel during a severe accident

International Nuclear Information System (INIS)

Noh, Sang W.; Suh, Kune Y.

2013-01-01

Highlights: ► Studied boiling on downward-facing hemispherical vessel with asymmetric thermal insulator. ► Scaled the APR1400 lower head linearly down by 1/10 including ICI tubes and shear keys. ► Performed thermal analysis using ANSYS V11.0 to determine the internal temperature and heat flux. ► Performed tests to obtain the CHF with saturated demineralized water at atmospheric pressure. ► Measured CHF accounting for 3D random flow effect expected in the APR1400 application. -- Abstract: Corium Ablation Stopper Apparatus (CASA) has a downward-facing hemispherical vessel and geometrically asymmetric thermal insulator of the Advanced Power Reactor 1400 MWe (APR1400) scaled linearly down by 1/10, as well as sixty-one in-core instrumentation (ICI) tubes and four shear keys. The heated vessel plays a pivotal role in CASA depending on the configuration of the oxide pool and metal layer to bring about the focusing effect expected of a molten pool in the lower head during a severe accident. The heated vessel was designed through a trial-and-error method and thermal analysis. Thermal analysis was performed using ANSYS V11.0 to investigate the effect of the internal temperature and heat flux on the integral hemispherical copper vessel. The CASA tests were carried out to obtain the critical heat flux (CHF) with saturated and demineralized water at the atmospheric pressure (0.1 MPa). The CHF in the metal layer through the hemispherical channel was found to be lower than that in the ULPU-2400 configuration V data through the streamlined thermal insulator. The experimental CHF was measured and obtained through the CASA hemispherical heated surface accounting for the three-dimensional random flow effect expected in the APR1400 application

Vibration Analysis for Steam Dryer of APR1400 Steam Generator

Energy Technology Data Exchange (ETDEWEB)

Han, Sung-heum; Ko, Doyoung [KHNP CRI, Daejeon (Korea, Republic of); Cho, Minki [Doosan Heavy Industry, Changwon (Korea, Republic of)

2016-10-15

This paper is related to comprehensive vibration assessment program for APR1400 steam generator internals. According to U.S. Nuclear Regulatory Commission, Regulatory Guide 1.20 (Rev.3, March 2007), we conducted vibration analysis for a steam dryer as the second steam separator of steam generator internals. The vibration analysis was performed at the 100 % power operating condition as the normal operation condition. The random hydraulic loads were calculated by the computational fluid dynamics and the structural responses were predicted by power spectral density analysis for the probabilistic method. In order to meet the recently revised U.S. NRC RG 1.20 Rev.3, the CVAP against the potential adverse flow effects in APR1400 SG internals should be performed. This study conducted the vibration response analysis for the SG steam dryer as the second moisture separator at the 100% power condition, and evaluated the structural integrity. The predicted alternating stress intensities were evaluated to have more than 17.78 times fatigue margin compared to the endurance limit.

Le carcinome neuro-endocrine cutané primitif: à propos d'un nouveau cas et revue de la littérature

Science.gov (United States)

Boukind, Samira; Elatiqi, Oumkeltoum; Dlimi, Meriem; Elamrani, Driss; Benchamkha, Yassine; Ettalbi, Saloua

2015-01-01

Le carcinome neuro- endocrine cutané primitif (CNEC) est une tumeur cutanée rare et agressive du sujet âgé, favorisée par le soleil et l'immunodépression. Elle est caractérisée par une évolution agressive avec un fort taux de récidive, une évolution ganglionnaire régionale et un risque de métastases à distance. Nous rapportons un cas de cette tumeur chez un patient âgé de 67 ans sous forme d'un placard nodulaire hémorragique mesurant 16 /14 cm. Le patient a bénéficié d'une exérèse chirurgicale large avec couverture de la perte de substance par un lambeau musculo-cutané du muscle grand dorsal, un curage ganglionnaire axillaire et une radiothérapie adjuvante. Après un recul de 2 ans et 2 mois, le patient est toujours vivant sans métastase ni récidive. La littérature étant pauvre, la prise en charge diagnostique et thérapeutique est controversée et donc hétérogène. Globalement le pronostic est mauvais, et certains paramètres corrélés au pronostic sont précisés. PMID:26185585

GPM GROUND VALIDATION AIRBORNE SECOND GENERATION PRECIPITATION RADAR (APR-2) GCPEX V1

Data.gov (United States)

National Aeronautics and Space Administration — The GPM Ground Validation Airborne Second Generation Precipitation Radar (APR-2) GCPEx dataset was collected during the GPM Cold-season Precipitation Experiment...

1001.pdf | 25apr2010 | currsci | Indian Academy of Sciences

Indian Academy of Sciences (India)

2010-04-25

Apr 25, 2010 ... error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube · Twitter · Facebook · Blog. Academy News. IAS Logo. Summer Research Fellowship Programme 2018. Dates Extended To 7 December 2017. Register here · Focus Area Science ...

Cerebral Scintigraphy in the Child and Nursing Infant; La Scintigraphie Cerebrale chez l'Enfant et le Nourrisson

Energy Technology Data Exchange (ETDEWEB)

Akerman, M.; Rougerie, J.; Guiot, G. [INSERM, Hopital Foch, Suresnes (France)

1969-05-15

overall results of cerebral scintigraphy are less favourable in the case of cerebral tumours in children than in that of adults. The reason for this is the high frequency in children of tumours of the brain stem, the pituitary and the third ventricle, the detectability of which is low. However, very good results were obtained in the case of 35 tumours of the cerebellum and the fourth ventricle as a result of using very rigorous techniques. Excellent results have also been obtained with other surgical lesions, such as chronic subdural haematoma in the nursing infant and vascular malformations. In conditions not amenable to neurosurgery definitely false results were the exception. Lastly, the authors present the initial results of a study of the cerebral cisterns and ventricles. They emphasize the abundance of information supplied by these scintigraphic methods and their great utility for the neurosurgeon. (author) [French] La scintigraphie cerebrale chez l' enfant a fait l'objet de peu de travaux publies. Une etude separee chez l' enfant se justifie cependant par les particularites de la pathologie neurochirurgicale infantile. L' exploration de l' enfant et du nourrisson conduit a discuter les donnees dosimetriques et a poser le probleme de la detectabilite des tumeurs de la fosse posterieure, des tumeurs medianes de la base du crane, et des astrocytomes, qui sont justement les tumeurs les plus frequentes en pathologie infantile. Enfin, l' enfant et le nourrisson sont les sujets d'application privilegies des techniques de scintigraphie apres injection locale de composes radioactifs, par voie sous- arachno'idienne, intra-ventriculaire, ou intra-cavitaire, pour 1' etude des hydrocephalies communicantes ou par stenose, des malformations meningo-encephaliques et des hematomes sous-duraux chroniques. En cinq ans ont ete explores 400 enfants et nourrissons ages de 2 mois a 16 ans, soit 10% des 4000 explorations craniennes effectuees dans le laboratoire des auteurs. Parmi ces

Study of secondary electronic emission in some piezo-electric materials: application to ultrasonic visualization; Etude de l'emission electronique secondaire de quelques materiaux piezoelectriques: application a la visualisation ultrasonore

Energy Technology Data Exchange (ETDEWEB)

Marini, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

Methods allowing the visualization of acoustic images appear at the moment to be of great interest in the field of non-destructive testing as well as in that of underwater detection. In order to carry out certain calculations on the operation of an ultrasonic camera, it has been necessary to study the secondary electron emission of some piezoelectric materials liable to be incorporated into the equipment. The secondary electron emission of insulators is a rather complex phenomenon; in order to find a rational explanation for the observations made, a theory has been developed for the energy spectrum of the emitted electrons. The experimental results of this work have then been used to build an ultrasonic visualization installation. Some examples of acoustic images which have been visualized are also presented. (author) [French] Les methodes qui permettent de visualiser des images acoustiques trouvent a l'heure actuelle un grand interet dans le domaine du controle non destructif comme dans celui de la detection sous-marine. De maniere a effectuer certains calculs sur le fonctionnement d'une camera ultrasons, il a ete necessaire d'etudier l'emission electronique secondaire de quelques materiaux piezoelectriques susceptibles d'etre utilises dans sa construction. L'emission electronique secondaire des isolants est un phenomene assez complexe et de maniere a trouver des explications coherentes aux observations effectuees, une theorie du spectre energetique des electrons emis a ete elaboree. Une installation de visualisation ultrasonore a alors ete realisee a partir des donnees experimentales de cette etude. Quelques exemples d'images acoustiques visualisees par cette methode sont egalement presentees. (auteur)

Improved Design of Crew Operation in Computerized Procedure System of APR1400

Energy Technology Data Exchange (ETDEWEB)

Seong, No Kyu; Jung, Yeon Sub; Sung, Chan Ho [KHNP, Daejeon (Korea, Republic of)

2016-05-15

The operators perform the paper-based procedures in analog-based conventional main control room (MCR) depending on only communications between operators except a procedure controller such as a Shift Supervisor (SS), however in digital-based MCR the operators can confirm the procedures simultaneously in own console when the procedure controller of computerized procedure (CP) opens the CP. The synchronization and a synchronization function between procedure controller and other operators has to be considered to support the function of crew operation. This paper suggests the improved design of crew operation in computerized procedure system of APR1400. This paper suggests the improved design of APR1400 CPS. These improvements can help operators perform the crew procedures more efficiently. And they reduce a burden of communication and misunderstanding of computerized procedures. These improvements can be applied to CPS after human factors engineering verification and validation.

Greta Kaits 9. apr. 1928 - 29. aug. 1946 : [luuletused] / Mats Traat

Index Scriptorium Estoniae

Traat, Mats, 1936-

2008-01-01

Sisu : Greta Kaits 9. apr. 1928 - 29. aug. 1946 ; Villem Hänilane 1898 - 1952 ; Peeter Pedak 1897 - 1953 ; Max Äidse 1903 - 1959 ; Lavinia Laidam ; Buchard Pruus ; Sergei Krivokopõtov ; Allan Luht 5. VII 1962 - 17. V 2007 ; Karl Saarmets 9. III 1924 - 14. IX 1981 ; Raimo Ritsik

Les pertes après récolte en Afrique : examen analytique et synthèse ...

International Development Research Centre (IDRC) Digital Library (Canada)

Partout en Afrique, les pertes après récolte le long de la chaîne alimentaire, de la ferme à la table, mettent en péril la sécurité alimentaire des agriculteurs dépourvus de ressources. La réduction des pertes après récolte peut aider à accroître la disponibilité, la qualité nutritionnelle et la salubrité des aliments, et à améliorer ...

Main steam line break accident simulation of APR1400 using the model of ATLAS facility

Science.gov (United States)

Ekariansyah, A. S.; Deswandri; Sunaryo, Geni R.

2018-02-01

A main steam line break simulation for APR1400 as an advanced design of PWR has been performed using the RELAP5 code. The simulation was conducted in a model of thermal-hydraulic test facility called as ATLAS, which represents a scaled down facility of the APR1400 design. The main steam line break event is described in a open-access safety report document, in which initial conditions and assumptionsfor the analysis were utilized in performing the simulation and analysis of the selected parameter. The objective of this work was to conduct a benchmark activities by comparing the simulation results of the CESEC-III code as a conservative approach code with the results of RELAP5 as a best-estimate code. Based on the simulation results, a general similarity in the behavior of selected parameters was observed between the two codes. However the degree of accuracy still needs further research an analysis by comparing with the other best-estimate code. Uncertainties arising from the ATLAS model should be minimized by taking into account much more specific data in developing the APR1400 model.

GPM GROUND VALIDATION AIRBORNE SECOND GENERATION PRECIPITATION RADAR (APR-2) GCPEX V1

Data.gov (United States)

National Aeronautics and Space Administration — The Second Generation Airborne Precipitation Radar (APR-2) is a dual-frequency (13 GHz and 35 GHz), Doppler, dual-polarization radar system. It has a downward...

The Gravity Makeup on the LORHR Event during Mid-loop Operation for APR1400

Energy Technology Data Exchange (ETDEWEB)

Kim, Cheol Woo; Lee, Yong Hee; Lee, Gyu Cheon; Kim, Shin Whan [KEPCO, Daejeon (Korea, Republic of)

2015-05-15

This paper is to investigate means of the available gravity makeup after the event to prevent or sustain the core uncovery and fuel failure for the typical advanced power reactor nuclear power plants (APR1400). Unlike the OPR1000 (optimized power reactor 1000 nuclear power plants), the refueling water storage tank of APR1400 cannot be used for gravity makeup since it is located on the bottom of the containment with a lower elevation than the reactor vessel. So, the other means of gravity makeup and their effect on the core uncovery are accounted. The use of the water used for the cask loading pit (CLP) during refueling or the safety injection line filling tank (SIFT), which are not designed for gravity makeup during the event, and safety injection tanks (SITs) are considered as the alternative source of makeup feed. The results show that gravity makeup of a SIT provides a sufficient operator action time for the LORHR with the station black out (SBO) during the mid-loop operation for the APR1400. From the LORHR event analysis, the effective means of gravity makeup for APR1400 to cope with this event concurrent loss of all AC power is determined as the gravity feed using SITs. Other means for gravity makeup using CLP or SIFT, which are not designed to mitigate the LORHR event, are evaluated as not effective to the event due to the large flow resistances and the low elevation head to overcome the system pressure increase during the LORHR. The use of one SIT and two SITs for the LORHR provides the core uncovery times as 3 hr 8 min and 4 hr 32 min extending 1 hr 15 min and 2 hr 38 min from the base case, respectively.

Gabriel Camps (1927-2002

Directory of Open Access Journals (Sweden)

Marceau Gast

2012-03-01

Full Text Available Le professeur Gabriel Camps nous a quittés le 6 septembre 2002, emporté par les suites d’une grave maladie. Né le 20 mai 1927 à Misserghin, en Oranie, il affirma très jeune de grandes capacités intellectuelles. Dès l’âge de huit ans il se passionnait déjà à identifier des collections de pièces romaines. Son père, ingénieur à la Société nationale des chemins de fer algériens, sut favoriser sa curiosité concernant l’histoire antique de l’Afrique du Nord. Après des études secondaires au lycée d’...

MELCOR code modeling for APR1400

Energy Technology Data Exchange (ETDEWEB)

Choi, Young; Park, S. Y.; Kim, D. H.; Ahn, K. I.; Song, Y. M.; Kim, S. D.; Park, J. H

2001-11-01

The severe accident phenomena of nuclear power plant have large uncertainties. For the retention of the containment integrity and improvement of nuclear reactor safety against severe accident, it is essential to understand severe accident phenomena and be able to access the accident progression accurately using computer code. Furthermore, it is important to attain a capability for developing technique and assessment tools for an advanced nuclear reactor design as well as for the severe accident prevention and mitigation. The objective of this report is to establish technical bases for an application of the MELCOR code to the Korean Next Generation Reactor (APR1400) by modeling the plant and analyzing plant steady state. This report shows the data and the input preparation for MELCOR code as well as state-state assessment results using MELCOR code.

An investigation of major influences on the seismic response of APR1400 reactor vessel internals - 15145

International Nuclear Information System (INIS)

Byun, Y.J.; Kim, J.G.; Sung, K.K.; Lee, D.H.

2015-01-01

This paper deals with 3 topics concerning the APR1400 reactor vessel internals (RVI) seismic analysis: nonlinear problems, approaches to account for uncertainties of seismic model, and dynamic responses to various seismic excitations. First, the noticeable nonlinear characteristics of the RVI seismic model are discussed, and the modeling methods for properly simulating the nonlinear behaviors of RVI under seismic loads are presented. By applying these methods to the seismic model, the seismic analysis can correctly predict the dynamic response of RVI. Next, two approaches to account for the uncertainties of seismic model are evaluated: the time history broadening method, and the sensitivity analysis based on NUREG-0800, Section 4.2, Appendix A. From the evaluation results, it is confirmed that the time history broadening method employed in the seismic analysis of APR1400 RVI sufficiently accounts for the uncertainty of seismic model. Finally, the response characteristics of APR1400 RVI to various seismic excitations are investigated. The seismic excitations corresponding to various soil profiles, including the effects of cracked and un-cracked concrete stiffness on the reactor containment building structure, are used as forcing functions. From this study, the effects of various site conditions on the dynamic response of APR1400 RVI are identified. As a result, the enveloped seismic responses obtained from this study will contribute to the development of RVI seismic design that covers a wide range of potential site conditions. (authors)

967.pdf | 10apr2010 | currsci | Indian Academy of Sciences

Indian Academy of Sciences (India)

2010-04-10

Apr 10, 2010 ... error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held from 29–30 June 2018 ...

Phylogenetic Diversity of aprA Genes in Subseafloor Sediments on the Northwestern Pacific Margin off Japan.

Science.gov (United States)

Aoki, Masataka; Kakiuchi, Ryota; Yamaguchi, Takashi; Takai, Ken; Inagaki, Fumio; Imachi, Hiroyuki

2015-01-01

Markedly diverse sequences of the adenosine-5'-phosphosulfate reductase alpha subunit gene (aprA), which encodes a key enzyme in microbial sulfate reduction and sulfur oxidation, were detected in subseafloor sediments on the northwestern Pacific off Japan. The aprA gene sequences were grouped into 135 operational taxonomic units (90% sequence identity), including genes related to putative sulfur-oxidizing bacteria predominantly detected in sulfate-depleted deep sediments. Our results suggest that microbial ecosystems in the subseafloor biosphere have phylogenetically diverse genetic potentials to mediate cryptic sulfur cycles in sediments, even where sulfate is rarely present.

Application of Nuclear Application Programs to APR1400 Simulator

International Nuclear Information System (INIS)

Hwang, Do Hyun; Lee, Myeong Soo; Hong, Jin Hyuk

2012-01-01

Advanced Power Reactor 1400MWe (APR1400) simulator has been developed and installed at Kori Training Center for operators of ShinKori no.3, 4 nuclear power plant by Korea Hydro and Nuclear Power,s Central Research Institute (KHNP CRI). NAPS (Nuclear Application Programs) is a computerbased system which provides operators with past and real-time information for monitoring and controlling NSSS (Nuclear Steam Supply System), BOP (Balance Of Plant) and Electric system. NAPS consists of several programs such as COLSS (Core Operating Limit Supervisory System), SPADES+ (Safety Parameter Display and Evaluation System), CEA (Control Element Assembly) Application Program, and so on. Each program makes calculations based on its own algorithm and provides information available for operation. In order to use NAPS programs with a simulator even though they are being used in a real plant, they should be modified to add several simulation functions such as reset, snap, run/freeze and backtrack required by ANSI/ANS-3.5 to the original NAPS functionality. On top of that, interfacing programs should be developed for the data communication between respective NAPS programs and simulator sever. The purpose of this paper is to provide the overall architecture of the communication system between NAPS and simulator model, and to describe the method to apply NAPS to APR1400 simulator

Cold-Leg Small Break LOCA Analysis of APR1400 Plant Using a SPACE/sEM Code

International Nuclear Information System (INIS)

Lim, Sang Gyu; Lee, Suk Ho; Yu, Keuk Jong; Kim, Han Gon; Lee, Jae Yong

2013-01-01

The Small Break Loss-of-Coolant Accident (SBLOCA) evaluation methodology (EM) for APR1400, called sEM, is now being developed using SPACE code. SPACE/sEM is to set up a conservative evaluation methodology in accordance with appendix K of 10 CFR 50. Major required and acceptable features of the evaluation models are described as below. - Fission product decay : 1.2 times of ANS97 decay curve - Critical flow model : Henry-Fauske Moody two phase critical flow model - Metal-Water reaction model : Baker-Just equation - Critical Heat Flux (CHF) : B and W, Barnett and Modified Barnett correlation - Post-CHF : Groeneveld 5.7 film boiling correlation A series of test matrix is established to validate SPACE/sEM code in terms of major SBLOCA phenomena, e.g. core level swelling and boiling, core heat transfer, critical flow, loop seal clearance and their integrated effects. The separated effect tests (SETs) and integrated effect tests (IETs) are successfully performed and these results shows that SPACE/sEM code has a conservatism comparing with experimental data. Finally, plant calculations of SBLOCA for APR1400 are conducted as described below. - Break location sensitivity : DVI line, hot-leg, cold-leg, pump suction leg. - Break size spectrum : 0.4ft 2 ∼0.02ft 2 (DVI) 0.5ft 2 ∼0.02ft 2 (hot-leg, cold-leg, pump suction leg) This paper deals with break size spectrum analysis of cold-leg break accidents. Based on the calculation results, emergency core cooling system (ECCS) performances of APR1400 and typical SBLOCA phenomena can be evaluated. Cold-leg SBLOCA analysis for APR1400 is performed using SPACE/sEM code under harsh environment condition. SPACE/sEM code shows the typical SBLOCA behaviors and it is reasonably predicted. Although SPACE/sEM code has conservative models and correlations based on appendix K of 10 CFR 50, PCT does not exceed the requirement (1477 K). It is concluded that ECCS in APR1400 has a sufficient performance in cold-leg SBLOCA

Cold-Leg Small Break LOCA Analysis of APR1400 Plant Using a SPACE/sEM Code

Energy Technology Data Exchange (ETDEWEB)

Lim, Sang Gyu; Lee, Suk Ho; Yu, Keuk Jong; Kim, Han Gon; Lee, Jae Yong [Central Research Institute, KHNP, Ltd., Daejeon (Korea, Republic of)

2013-10-15

The Small Break Loss-of-Coolant Accident (SBLOCA) evaluation methodology (EM) for APR1400, called sEM, is now being developed using SPACE code. SPACE/sEM is to set up a conservative evaluation methodology in accordance with appendix K of 10 CFR 50. Major required and acceptable features of the evaluation models are described as below. - Fission product decay : 1.2 times of ANS97 decay curve - Critical flow model : Henry-Fauske Moody two phase critical flow model - Metal-Water reaction model : Baker-Just equation - Critical Heat Flux (CHF) : B and W, Barnett and Modified Barnett correlation - Post-CHF : Groeneveld 5.7 film boiling correlation A series of test matrix is established to validate SPACE/sEM code in terms of major SBLOCA phenomena, e.g. core level swelling and boiling, core heat transfer, critical flow, loop seal clearance and their integrated effects. The separated effect tests (SETs) and integrated effect tests (IETs) are successfully performed and these results shows that SPACE/sEM code has a conservatism comparing with experimental data. Finally, plant calculations of SBLOCA for APR1400 are conducted as described below. - Break location sensitivity : DVI line, hot-leg, cold-leg, pump suction leg. - Break size spectrum : 0.4ft{sup 2}∼0.02ft{sup 2}(DVI) 0.5ft{sup 2}∼0.02ft{sup 2}(hot-leg, cold-leg, pump suction leg) This paper deals with break size spectrum analysis of cold-leg break accidents. Based on the calculation results, emergency core cooling system (ECCS) performances of APR1400 and typical SBLOCA phenomena can be evaluated. Cold-leg SBLOCA analysis for APR1400 is performed using SPACE/sEM code under harsh environment condition. SPACE/sEM code shows the typical SBLOCA behaviors and it is reasonably predicted. Although SPACE/sEM code has conservative models and correlations based on appendix K of 10 CFR 50, PCT does not exceed the requirement (1477 K). It is concluded that ECCS in APR1400 has a sufficient performance in cold-leg SBLOCA.

Study of a high surface gas triode for detecting atomic or nuclear particles; Etude d'une triode a gaz a grande surface detectrice de particules atomiques ou nucleaires

Energy Technology Data Exchange (ETDEWEB)

Lansiart, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-06-15

A triode filled with xenon at atmospheric pressure can be used as an X-ray detector since it produces an appreciable amount of light per quantum absorbed. Various methods are described for studying and reducing the deadtime after the passage of a spark. This detector can be used in medicine for the detection of tumours and also for the rapid recording of diffraction diagrams. (author) [French] Une triode, remplie de xenon a la pression atmospherique, sert de detecteur de rayors X en fournissant une quantite de lumiere importante par quantum absorbe. Diverses methodes sont decrites permettant d'etudier et de reduire le temps mort apres le passage d'une etincelle. Ce detecteur sert a la localisation de tumeurs en medecine et a l'enregistrement rapide de diagrammes de diffraction. (auteur)

Cancer du rein et Grossesse: A propos d’une nouvelle observation

Directory of Open Access Journals (Sweden)

A. Majdoub

2017-12-01

Nous rapportons le cas d’une patiente âgée de 38 ans, sans antécédents pathologiques notables, enceinte avec un terme de 16 semaines d’aménorrhée, présentant des lombalgies gauches. Le diagnostic de tumeur rénale était retenu sur les données du couple échographie rénale et IRM abdominale. La patiente a bénéficié d’une néphrectomie élargie par voie lombaire. L’analyse histologique de la pièce de néphrectomie totale a révélé un adénocarcinome à cellules claires. L’évolution était favorable après le traitement avec une grossesse menée à terme.

Study of a high surface gas triode for detecting atomic or nuclear particles; Etude d'une triode a gaz a grande surface detectrice de particules atomiques ou nucleaires

Energy Technology Data Exchange (ETDEWEB)

Lansiart, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-06-15

A triode filled with xenon at atmospheric pressure can be used as an X-ray detector since it produces an appreciable amount of light per quantum absorbed. Various methods are described for studying and reducing the deadtime after the passage of a spark. This detector can be used in medicine for the detection of tumours and also for the rapid recording of diffraction diagrams. (author) [French] Une triode, remplie de xenon a la pression atmospherique, sert de detecteur de rayors X en fournissant une quantite de lumiere importante par quantum absorbe. Diverses methodes sont decrites permettant d'etudier et de reduire le temps mort apres le passage d'une etincelle. Ce detecteur sert a la localisation de tumeurs en medecine et a l'enregistrement rapide de diagrammes de diffraction. (auteur)

Neuchatel ne gardera pas le Palais de l'equilibre apres Expo.02

CERN Multimedia

2002-01-01

"La ville de Neuchatel ne souhaite pas conserver le Palais de l'equilibre apres Expo.02. Par 24 voix contre 7, le Conseil general a rejete le plan special du Conseil communal qui proposait de transformer l'edifice en un centre de congres" (1/2 page).

RESPONSE OF SELECTED LOCAL PLANTAIN CULTIVARS TO PIBS (PLANTS ISSUS DE BOURGEONS SECONDAIRES TECHNIQUE

Directory of Open Access Journals (Sweden)

Beloved Mensah DZOMEKU

2014-12-01

Full Text Available One major constraint to plantain production has been inadequate healthy planting materials at the time of planting. Several technologies for multiplying healthy planting materials exist but could not meet farmers’ demand. A study was conducted to assess the performance of various landraces plantain to plants issus de bourgeons secondaires (PIBS technique. Five cultivars of Musa sapientum (Apantu (False Horn, Asamienu (True Horn, Oniaba (intermediate French plantain and FHIA-21 (tetraploid hybrid plantain were tested to determine their response to the PIBS technique. Sword suckers of each cultivar with weight of between 0.2-0.5 kg were prepared and buried in fine sawdust in a humidity chamber built using transparent polyethylene sheets. Results at harvest showed that removal of rooted sprouts started three weeks after planting and every week thereafter for eight weeks. The intermediate French plantain cultivar (Oniaba produced the least average number (about 20 of healthy planting. Apantu (False Horn produced an average of about 75 healthy planting materials. The hybrid FHIA-21 on the other hand generated an average of about 85 healthy planting materials. Asamienu (True Horn produced the highest healthy seedlings of about 90 healthy planting materials. The results revealed that the leaf scar carries a primary bud at the intersection of each leaf sheath and several eyes along the entire length of the leaf sheath which could not have developed into suckers. However, with this technique the eyes could be activated to sprout as healthy planting materials. The technique proved as an efficient method of multiplying healthy planting materials for plantain and could thus be recommended for adoption not only by peasant farmers but also to others who could become commercial seed producers. But there will be a need for certification guidelines for seed growing systems.

Progress of Design Improvements for APR1400 Computerized Procedure System from HFE V and V results and Design Experience

International Nuclear Information System (INIS)

Lee, Sungjin; Seong, Nokyu

2015-01-01

This study shows major already improved design features from the above three processes and a design proposal for to-be-improving items. APR1400 CPS has been verified and validated by the HFE process, internal design review and site acceptance tests. APR1400 Computerized Procedure System (CPS) has been applied to Shin-Kori Nuclear Power Plant (SKN) 3 and 4 units, Shin-Hanul Nuclear Power Plant (SHN) 1 and 2 units and Baraka Nuclear Power Plant (BNPP) 1, 2, 3 and 4 units. Since APR1400 CPS is a first-of-a-kind (FOAK) human machine interface (HMI) for executing a computerized procedure in the nuclear power plant's main control room in South Korea, it has been continuously improved through a) the human factor engineering (HFE) verification and validation (V and V), b) the internal design review and c) prototype tests. Human engineering discrepancies (HEDs) can be identified by the HFE V and V activity. Some HEDs of APR1400 CPS for SKN 3 and 4 and SHN 1 and 2 have been adopted as a role of design improvement in the CPS system while others were regarded as an operator training requirement or part of task contents. Various requests for improving the CPS have been collected from those results. A HMI system should be improved continuously for removing potential defects. Some of introduced design features in this paper has been adopted for APR1400 nuclear power plants. Some of them are under the review in the CPS design team of KHNP

Application of Standardized ITAAC to the APR1400 Design Certification

Energy Technology Data Exchange (ETDEWEB)

Kang, Deogji; Kim, Yunho [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

Design certification applications (DCAs) submitted pursuant to 10 CFR Part 52 contain two tiers of information, Tier 1 and Tier 2. Tier 1 contains information that is to be certified through rulemaking, and includes the inspections, tests, analyses, and acceptance criteria (ITAAC). Tier 2 contains more detailed information and is the source for information included in Tier1. DC applicants have developed the ITAAC with their own format and contents. This has caused the ineffectiveness of the review process by Nuclear Regulatory Commission (NRC) at the design certification stage. Standardizing the format and content of Tier 1 and ITAAC will achieve greater efficiency and effectiveness for Tier 1 and ITAAC development and NRC review, and for ITAAC implementation and verification. NRC provided the proposed standardized ITAAC for APR1400, and KHNP is considering the application of the proposed ITAAC. The strategy for application of the NRC proposed standardized ITAAC to the APR1400 design certification is now under developing, and a meeting with NRC to review the NRC proposed standardized ITAAC is expected to be held in the near future. In this review process, establishment of industry position on the NRC proposed standardized ITAAC is very important. The support from NEI and US industry is expected to be gained.

Application of Standardized ITAAC to the APR1400 Design Certification

International Nuclear Information System (INIS)

Kang, Deogji; Kim, Yunho

2016-01-01

Design certification applications (DCAs) submitted pursuant to 10 CFR Part 52 contain two tiers of information, Tier 1 and Tier 2. Tier 1 contains information that is to be certified through rulemaking, and includes the inspections, tests, analyses, and acceptance criteria (ITAAC). Tier 2 contains more detailed information and is the source for information included in Tier1. DC applicants have developed the ITAAC with their own format and contents. This has caused the ineffectiveness of the review process by Nuclear Regulatory Commission (NRC) at the design certification stage. Standardizing the format and content of Tier 1 and ITAAC will achieve greater efficiency and effectiveness for Tier 1 and ITAAC development and NRC review, and for ITAAC implementation and verification. NRC provided the proposed standardized ITAAC for APR1400, and KHNP is considering the application of the proposed ITAAC. The strategy for application of the NRC proposed standardized ITAAC to the APR1400 design certification is now under developing, and a meeting with NRC to review the NRC proposed standardized ITAAC is expected to be held in the near future. In this review process, establishment of industry position on the NRC proposed standardized ITAAC is very important. The support from NEI and US industry is expected to be gained

Valorisation par voie hydrométallurgique de Matières Premières Secondaires Valorization of Secondary Raw Materials by hydrometallurgical way

Directory of Open Access Journals (Sweden)

Meux Eric

2013-11-01

Full Text Available Cet exposé s'intéressera à la récupération par voie hydrométallurgique de métaux contenus dans les Matières Premières Secondaires. Dans un premier temps seront abordées des généralités sur les Métaux Critiques, leur taux de recyclage et les gisements identifiés. Deux exemples de traitement seront ensuite développés : le traitement de catalyseurs d'hydrotraitement et le traitement de poudres métallifères issues de broyats d'accumulateurs par couplage électrolixiviation/électrodéposition. This talk will focus on the hydrometallurgical recovery of metals contained in secondary raw materials. At first, generalities about critical metals, their recycling rate and their identified supply will be addressed. Two examples of hydrometallurgical treatment will be then developed: the treatment of spent hydrotreating catalysts and the treatment of electrodes powders coming from grinding of spent batteries by coupling electroleaching/electrodeposition.

The comparison between layout and design of APR1400 MCR and EPRI requirement

International Nuclear Information System (INIS)

Suharyo Widagdo; Darlis; Sigit Santoso; T J Suryono

2013-01-01

A good man-machine interface system is needed by a nuclear power reactor because of its complexity and high safety factor. The man-machine interface system is centralized in the main control room (MCR). All of monitoring and controlling activity to keep the installation operation safety can be done from this place. In order to increase its ability in monitoring and controlling a hard effort to raise the interface system to the highest possible level is done not only by using the latest computer technology and instrumentation system but also using Human Engineering, as well. The paper aims to compare the lay out and design the APR1400 MCR and the requirement from EPRI about main control room lay out and design as response of TMI-2 accident. We can see from the discussion that the design of the MCR of APR1400 have been applied the request of EPRI. (author)

Effect of the design change of the LSSBP on core flow distribution of APR+ Reactor

International Nuclear Information System (INIS)

Kim, Kihwan; Euh, Dong-Jin; Choi, Hae-Seob; Kwon, Tae-Soon

2014-01-01

The uniform core inlet flow distribution of an Advanced Power Reactor Plus (APR+) is required to prevent the failure rate of the HIPER fuel assembly and improve the core thermal margin. KEPCO-E and C and KAERI proposed a design change of the Lower Support Structure Bottom Plate (LSSBP), since the core flow rates were intense near the outer region of the intact LSSBP in a previous study. In this study, an experiment was carried out to evaluate the effect of the design change of the LSSBP on the core flow distribution using the APR+ Core Flow and Pressure (ACOP) test facility. The results showed great improvement on the core flow distribution under a 4-pump balanced flow condition. Under the 4-pump balanced flow condition, fifteen tests were repeated using the ACOP test facility to verify the effect of the 50% blocked flow area at the outer region of the LSSBP on the core inlet flow distribution. The profiles of the core inlet mass flow rates were analyzed using ensemble averaged values, and compared with that of the intact LSSBP. The results showed great improvement for the overall core region. The change in design of the LSSBP is expected to improve the hydraulic performance of an APR+ reactor

Extended Station Blackout Analyses of an APR1400 with MARS-KS

International Nuclear Information System (INIS)

Kim, WoongBae; Jang, HyungWook; Oh, Seungjong; Lee, Sangyong

2016-01-01

The Fukushima Dai-ichi nuclear power plant accident shows that natural disasters such as earthquakes and the subsequent tsunamis can cause station blackout for several days. The electricity required for essential systems during a station blackout is provided from the emergency backup batteries installed at the nuclear power plant. In South Korea, in the event of an extended station blackout, the life of these emergency backup batteries has recently been extended from 8 hours to 24 hours at Shin-Kori 5, 6 and APR1400 for design certification. For a battery life of 24 hours, available safety means system, equipment and procedures are studied and analyzed in their ability to cope with an extended station blackout. A sensitivity study of reactor coolant pump seal leakage is performed to verify how different seal leakages could affect the system. For simulating of extended station blackout scenarios, the best estimate MARS-KS was used. In this paper, an APR1400 RELAP5 input deck was developed for station blackout scenario to analyze operation strategy by manually depressurizing the reactor coolant system through the steam generator's secondary side. Additionally, a sensitivity study was performed on reactor coolant pump seal leakage

Extended Station Blackout Analyses of an APR1400 with MARS-KS

Energy Technology Data Exchange (ETDEWEB)

Kim, WoongBae; Jang, HyungWook; Oh, Seungjong; Lee, Sangyong [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2016-10-15

The Fukushima Dai-ichi nuclear power plant accident shows that natural disasters such as earthquakes and the subsequent tsunamis can cause station blackout for several days. The electricity required for essential systems during a station blackout is provided from the emergency backup batteries installed at the nuclear power plant. In South Korea, in the event of an extended station blackout, the life of these emergency backup batteries has recently been extended from 8 hours to 24 hours at Shin-Kori 5, 6 and APR1400 for design certification. For a battery life of 24 hours, available safety means system, equipment and procedures are studied and analyzed in their ability to cope with an extended station blackout. A sensitivity study of reactor coolant pump seal leakage is performed to verify how different seal leakages could affect the system. For simulating of extended station blackout scenarios, the best estimate MARS-KS was used. In this paper, an APR1400 RELAP5 input deck was developed for station blackout scenario to analyze operation strategy by manually depressurizing the reactor coolant system through the steam generator's secondary side. Additionally, a sensitivity study was performed on reactor coolant pump seal leakage.

Evaluation of Ablation rate by the change of Sacrificial Material for PECS in EU-APR

International Nuclear Information System (INIS)

Hwang, Do Hyun; Kim, Yong Soo; Lee, Keun Sung

2015-01-01

EU-APR, modified and improved from its original design of APR1400, has been developed to comply with European Utility Requirements (EUR) and nuclear design requirements of the European countries. In EU-APR, Severe Accident Mitigation Systems are dedicated to providing an independent defense line from that of Engineered Safety Feature (ESF) and Diverse Safety Feature (DSF). They consist of Emergency Reactor Depressurization System (ERDS), Passive Ex-vessel corium retaining and Cooling System (PECS), Severe Accident Containment Spray System (SACSS), Hydrogen Mitigation System (HMS) and Containment Filtered Vent System (CFVS). The PECS, so called core catcher, was introduced to prevent the Molten Core Concrete Interaction (MCCI) after Reactor Vessel (RV) failure. The PECS has experienced a lot of changes from its original design. Recently, the most significant change was that as a SM, limestone concrete is installed on PECS's body wall instead of previous sacrificial material rich in Fe 2 O 3 . The main reason of this design change is to overcome the issue that the sacrificial material is ablated rather too fast when reacting with corium that contains a large fraction of Zr metal. Other changes in the geometry of PECS's wall and downcomer design are considered as minor ones. In this paper, the comparison of ablation rates between previous SM and limestone concrete is carried out using MAAP5 code with respective MCCI model according to the material. In this paper, major improvements of MAAP5 model for PECS in EU-APR are presented and the evaluation of ablation rate for the previous SM model and the new LC model is carried out by means of ablation depths with LBLOCA sequence. Two models have respective unique ablation process. The ablation of LC model proceeds at a constant rate regardless of water while the ablation of SM model proceeds at a faster rate before the arrival of cooling water for corium and SM mixture. The change of sacrificial material also

The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates.

Directory of Open Access Journals (Sweden)

Ruth M Kennan

Full Text Available Many bacterial pathogens produce extracellular proteases that degrade the extracellular matrix of the host and therefore are involved in disease pathogenesis. Dichelobacter nodosus is the causative agent of ovine footrot, a highly contagious disease that is characterized by the separation of the hoof from the underlying tissue. D. nodosus secretes three subtilisin-like proteases whose analysis forms the basis of diagnostic tests that differentiate between virulent and benign strains and have been postulated to play a role in virulence. We have constructed protease mutants of D. nodosus; their analysis in a sheep virulence model revealed that one of these enzymes, AprV2, was required for virulence. These studies challenge the previous hypothesis that the elastase activity of AprV2 is important for disease progression, since aprV2 mutants were virulent when complemented with aprB2, which encodes a variant that has impaired elastase activity. We have determined the crystal structures of both AprV2 and AprB2 and characterized the biological activity of these enzymes. These data reveal that an unusual extended disulphide-tethered loop functions as an exosite, mediating effective enzyme-substrate interactions. The disulphide bond and Tyr92, which was located at the exposed end of the loop, were functionally important. Bioinformatic analyses suggested that other pathogenic bacteria may have proteases that utilize a similar mechanism. In conclusion, we have used an integrated multidisciplinary combination of bacterial genetics, whole animal virulence trials in the original host, biochemical studies, and comprehensive analysis of crystal structures to provide the first definitive evidence that the extracellular secreted proteases produced by D. nodosus are required for virulence and to elucidate the molecular mechanism by which these proteases bind to their natural substrates. We postulate that this exosite mechanism may be used by proteases produced by

Pneumoblastome de l'adulte: rapport d'un nouveau cas et revue de ...

African Journals Online (AJOL)

Le blastome pulmonaire décrit surtout chez les enfants, est une tumeur rare. Elle représente 0.25 à 0.5% de toutes les tumeurs pulmonaires avec un pronostic très grave. Sur le plan histologique, il s'agit d'une tumeur à double composante: une composante épithéliale et une composante mésenchymateuse. Cliniquement ...

Investigation of the Condensation Effect at IRWST Pool Surface on Containment Back Pressure in APR1400 Containment

International Nuclear Information System (INIS)

Lee, Eui Jong; Lee, Jin Yong; Lee, Byung Chul

2006-01-01

The APR1400 has several new design concepts in order to improve the plant safety functions during a postulated accident. The In-Containment Refueling Water Storage Tank (IRWST) is one of the new design concepts of APR1400 and installed at the bottom of containment building to promote the plant safety functions by simplifying emergency core cooling water source and preventing release of the fission product during an accidents. This design feature, however, brings about uncertainty factors which may necessitate conventional prediction of temperature and pressure of containment building improved or revised under accident conditions. The hot steam which is released from RCS break enters into the IRWST through four Pressure Relief Dampers (PRDs). It is expected to be condensed with water stored in IRWST, colder than incoming steam. The purpose of this study is to examine closely the influence of the condensation effect at IRWST on containment back pressure in APR1400 containment building using the GOTHIC code which can predict the steam condensation on IRWST pool surface

Fistules scrotales révélant un adénocarcinome mucineux du scrotum: à propos d’un cas

Science.gov (United States)

El Alaoui, Abdelilah; El Boté, Hicham; Ziouani, Oussama; Dembele, Oussman; El Sayegh, Hachem; Iken, Ali; Benslimane, Lounis; Nouini, Yassine

2017-01-01

Les fistules scrotales sont rares, et souvent secondaires à des lésions de tuberculose. Les adénocarcinomes mucineux sont des tumeurs qui renferment au moins 50% de mucus extracellulaire, et siègent préférentiellement sur le recto sigmoïde, la localisation scrotale est inhabituelle. Nous rapportons un cas d’adénocarcinome mucineux secondaire du scrotum révélé par des fistules scrotales, chez un patient âgé de 54 ans, sans antécédents pathologiques notables, qui présente depuis deux ans des fistules scrotales à répétition, sans autres signes associés. L’examen trouve de multiples fistules scrotales avec issue de pus épais, le toucher rectal est normal. Les explorations urologiques (UIV, UCRM, Cystoscopie, …) sont normales, le bilan infectieux ainsi que la recherche de BK dans les urines et le crachat sont négatives. La biopsie de la peau scrotale est revenue en faveur d’un adénocarcinome mucineux moyennement différencié, dont l’étude immun histochimique est en faveur d’une origine primitive colorectale. L’évolution a été marqué par l’apparition de fistules anales complexes, ayant a l’IRM une caractéristique active, alimentant plusieurs collections pelvi périnéales comportant des bourgeons charnus. Sur le plan thérapeutique et vu la rareté de ce cancer, il n’y a pas de consensus. La résection chirurgicale reste le traitement de choix pour cette affection. La radio chimiothérapie pré opératoire est préconisée pour ce type de cancer mais son rôle n’est pas bien établi. Chez notre patient on a opté pour une radio chimiothérapie néo adjuvante première, avant la réalisation d’une amputation abdomino- périnéale. PMID:28674583

The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study : rationale and methods

NARCIS (Netherlands)

Kaplan, Bonnie J.; Giesbrecht, Gerald F.; Leung, Brenda M. Y.; Field, Catherine J.; Dewey, Deborah; Bell, Rhonda C.; Manca, Donna P.; O'Beirne, Maeve; Johnston, David W.; Pop, Victor J.; Singhal, Nalini; Gagnon, Lisa; Bernier, Francois P.; Eliasziw, Misha; McCargar, Linda J.; Kooistra, Libbe; Farmer, Anna; Cantell, Marja; Goonewardene, Laki; Casey, Linda M.; Letourneau, Nicole; Martin, Jonathan W.

The Alberta Pregnancy Outcomes and Nutrition (APrON) study is an ongoing prospective cohort study that recruits pregnant women early in pregnancy and, as of 2012, is following up their infants to 3 years of age. It has currently enrolled approximately 5000 Canadians (2000 pregnant women, their

The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study : Rationale and methods

NARCIS (Netherlands)

Kaplan, B.J.; Giesbrecht, G.F.; Leung, B.M.; Field, C.J.; Dewey, D.; Bell, R.C.; Manca, D.P.; O'Beirne, M.; Johnston, D.W.; Pop, V.J.M.; Singhal, N.; Gagnon, L.; Bernier, F.P.; Eliasziw, M.; McCargar, L.J.; Kooistra, L.; Farmer, A.; Cantell, M.; Goonewardene, L.; Casey, L.M.; Letourneau, N.; Martin, J.W.

2014-01-01

The Alberta Pregnancy Outcomes and Nutrition (APrON) study is an ongoing prospective cohort study that recruits pregnant women early in pregnancy and, as of 2012, is following up their infants to 3 years of age. It has currently enrolled approximately 5000 Canadians (2000 pregnant women, their

Calculation of fuel and moderator temperature coefficients in APR1400 nuclear reactor by MVP code

International Nuclear Information System (INIS)

Pham Tuan Nam; Le Thi Thu; Nguyen Huu Tiep; Tran Viet Phu

2014-01-01

In this project, these fuel and moderator temperature coefficients were calculated in APR1400 nuclear reactor by MVP code. APR1400 is an advanced water pressurized reactor, that was researched and developed by Korea Experts, its electric power is 1400 MW. The neutronics calculations of full core is very important to analysis and assess a reactor. Results of these calculation is input data for thermal-hydraulics calculations, such as fuel and moderator temperature coefficients. These factors describe the self-safety characteristics of nuclear reactor. After obtaining these reactivity parameters, they were used to re-run the thermal hydraulics calculations in LOCA and RIA accidents. These thermal-hydraulics results were used to analysis effects of reactor physics parameters to thermal hydraulics situation in nuclear reactors. (author)

Case report

African Journals Online (AJOL)

abp

29 déc. 2015 ... Abstract. Les tumeurs rétro rectales kystiques et solides sont très variées et rare chez l'adulte. Elles sont dominées par les chordomes qui sont des tumeurs à malignité locale essentiellement observées chez les sujets de sexe masculin, alors les tumeurs kystiques vestigiales, sont souvent bénignes et.

Esthesioneuroblastome : dilemme diagnostic et challenge ...

African Journals Online (AJOL)

Introduction : L'esthésioneuroblastome est une tumeur maligne rare des fosses nasales. Il s'agit d'une tumeur agressive et récidivante dont le traitement est controversé. Notre objectif est de décrire les particularités diagnostiques et les actualités thérapeutiques de cette tumeur. Matériels et méthode : Etude rétrospective sur ...

The effect of nodalization and temperature of reactor upper region: Sensitivity analysis for APR-1400 LBLOCA

International Nuclear Information System (INIS)

Kang, Dong Gu

2017-01-01

Highlights: • The nodalization of APR-1400 was modified to reflect the characteristic of upper region temperature. • The effect of nodalization and temperature of reactor upper region on LBLOCA consequence was evaluated. • The modification of nodalization is an essential prerequisite in APR-1400 LBLOCA analysis. - Abstract: In best estimate (BE) calculation, the definition of system nodalization is important step influencing the prediction accuracy for specific thermal-hydraulic phenomena. The upper region of reactor is defined as the region of the upper guide structure (UGS) and upper dome. It has been assumed that the temperature of upper region is close to average temperature in most large break loss of coolant accident (LBLOCA) analysis cases. However, it was recently found that the temperature of upper region of APR-1400 reactor might be little lower than or similar to hot leg temperature through the review of detailed design data. In this study, the nodalization of APR-1400 was modified to reflect the characteristic of upper region temperature, and the effect of nodalization and temperature of reactor upper region on LBLOCA consequence was evaluated by sensitivity analysis including best estimate plus uncertainty (BEPU) calculation. In basecase calculation, in case of modified version, the peak cladding temperature (PCT) in blowdown phase became higher and the blowdown quenching (or cooling) was significantly deteriorated as compared to original case, and as a result, the cladding temperature in reflood phase became higher and the final quenching was also delayed. In addition, thermal-hydraulic parameters were compared and analyzed to investigate the effect of change of upper region on cladding temperature. In BEPU analysis, the 95 percentile PCT used in current regulatory practice was increased due to the modification of upper region nodalization, and it occurred in the reflood phase unlike original case.

Seismic analysis of the APR1400 nuclear reactor system using a verified beam element model

Energy Technology Data Exchange (ETDEWEB)

Park, Jong-beom [Department of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722 (Korea, Republic of); Park, No-Cheol, E-mail: pnch@yonsei.ac.kr [Department of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722 (Korea, Republic of); Lee, Sang-Jeong; Park, Young-Pil [Department of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722 (Korea, Republic of); Choi, Youngin [Korea Institute of Nuclear Safety, 62 Gwahak-ro, Yuseong-gu, Daejeon 34142 (Korea, Republic of)

2017-03-15

Highlights: • A simplified beam element model is constructed based on the real dynamic characteristics of the APR1400. • Time history analysis is performed to calculate the seismic responses of the structures. • Large deformations can be observed at the in-phase mode of reactor vessel and core support barrel. - Abstract: Structural integrity is the first priority in the design of nuclear reactor internal structures. In particular, nuclear reactor internals should be designed to endure external forces, such as those due to earthquakes. Many researchers have performed finite element analyses to meet these design requirements. Generally, a seismic analysis model should reflect the dynamic characteristics of the target system. However, seismic analysis based on the finite element method requires long computation times as well as huge storage space. In this research, a beam element model was developed and confirmed based on the real dynamic characteristics of an advanced pressurized water nuclear reactor 1400 (APR1400) system. That verification process enhances the accuracy of the finite element analysis using the beam elements, remarkably. Also, the beam element model reduces seismic analysis costs. Therefore, the beam element model was used to perform the seismic analysis. Then, the safety of the APR1400 was assessed based on a seismic analysis of the time history responses of its structures. Thus, efficient, accurate seismic analysis was demonstrated using the proposed beam element model.

Seismic analysis of the APR1400 nuclear reactor system using a verified beam element model

International Nuclear Information System (INIS)

Park, Jong-beom; Park, No-Cheol; Lee, Sang-Jeong; Park, Young-Pil; Choi, Youngin

2017-01-01

Highlights: • A simplified beam element model is constructed based on the real dynamic characteristics of the APR1400. • Time history analysis is performed to calculate the seismic responses of the structures. • Large deformations can be observed at the in-phase mode of reactor vessel and core support barrel. - Abstract: Structural integrity is the first priority in the design of nuclear reactor internal structures. In particular, nuclear reactor internals should be designed to endure external forces, such as those due to earthquakes. Many researchers have performed finite element analyses to meet these design requirements. Generally, a seismic analysis model should reflect the dynamic characteristics of the target system. However, seismic analysis based on the finite element method requires long computation times as well as huge storage space. In this research, a beam element model was developed and confirmed based on the real dynamic characteristics of an advanced pressurized water nuclear reactor 1400 (APR1400) system. That verification process enhances the accuracy of the finite element analysis using the beam elements, remarkably. Also, the beam element model reduces seismic analysis costs. Therefore, the beam element model was used to perform the seismic analysis. Then, the safety of the APR1400 was assessed based on a seismic analysis of the time history responses of its structures. Thus, efficient, accurate seismic analysis was demonstrated using the proposed beam element model.

Characterisation of the thermostable protease AprX in strains of Pseudomonas fluorescens and impact on the shelf-life of dairy products: preliminary results

Directory of Open Access Journals (Sweden)

Nadia Andrea Andreani

2016-12-01

Full Text Available Bacterial proteases are involved in food spoilage and shelf-life reduction. Among the bacterial proteases, a predominant role in spoilage of dairy products seems to be played by the thermostable metallo-protease AprX, which is produced by various strains of Pseudomonas fluorescens. Differences in AprX enzyme activity among different strains were highlighted, but the most proteolytic strains were not identified. In this study, the presence of the aprX gene was evaluated in 69 strains isolated from food matrices and 18 reference strains belonging to the P. fluorescens group, which had been previously typed by the multi locus sequence typing method. Subsequently, a subset of reference strains was inoculated in ultra-high temperature milk, and the expression of the aprX gene was evaluated at 22 and 6°C. On the same milk samples, the proteolytic activity was then evaluated through Azocasein and trinitrobenzenesulfonic acid solution assays. Finally, to assess the applicability of the former assay directly on dairy products the proteolityc activity was tested on industrial ricotta samples using the Azocasein assay. These results demonstrate the spread of aprX gene in most strains tested and the applicability of Azocasein assay to monitor the proteolytic activity in dairy products.

Complex regulation of AprA metalloprotease in Pseudomonas fluorescens M114: evidence for the involvement of iron, the ECF sigma factor, PbrA and pseudobactin M114 siderophore.

Science.gov (United States)

Maunsell, Bláithín; Adams, Claire; O'Gara, Fergal

2006-01-01

In the soil bacterium Pseudomonas fluorescens M114, extracellular proteolytic activity and fluorescent siderophore (pseudobactin M114) production were previously shown to be co-ordinately negatively regulated in response to environmental iron levels. An iron-starvation extracytoplasmic function sigma factor, PbrA, required for the transcription of siderophore biosynthetic genes, was also implicated in M114 protease regulation. The current study centred on the characterization and genetic regulation of the gene(s) responsible for protease production in M114. A serralysin-type metalloprotease gene, aprA, was identified and found to encode the major, if not only, extracellular protease produced by this strain. The expression of aprA and its protein product were found to be subject to complex regulation. Transcription analysis confirmed that PbrA was required for full aprA transcription under low iron conditions, while the ferric uptake regulator, Fur, was implicated in aprA repression under high iron conditions. Interestingly, the iron regulation of AprA was dependent on culture conditions, with PbrA-independent AprA-mediated proteolytic activity observed on skim milk agar supplemented with yeast extract, when supplied with iron or purified pseudobactin M114. These effects were not observed on skim milk agar without yeast extract. PbrA-independent aprA expression was also observed from a truncated transcriptional fusion when grown in sucrose asparagine tryptone broth supplied with iron or purified pseudobactin M114. Thus, experimental evidence suggested that iron mediated its effects via transcriptional activation by PbrA under low iron conditions, while an as-yet-unidentified sigma factor(s) may be required for the PbrA-independent aprA expression and AprA proteolytic activity induced by siderophore and iron.

Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine.

Science.gov (United States)

Seid, Christopher A; Curti, Elena; Jones, R Mark; Hudspeth, Elissa; Rezende, Wanderson; Pollet, Jeroen; Center, Lori; Versteeg, Leroy; Pritchard, Sonya; Musiychuk, Konstantin; Yusibov, Vidadi; Hotez, Peter J; Bottazzi, Maria Elena

2015-01-01

Over 400 million people living in the world's poorest developing nations are infected with hookworms, mostly of the genus Necator americanus. A bivalent human hookworm vaccine composed of the Necator americanus Glutathione S-Transferase-1 (Na-GST-1) and the Necator americanus Aspartic Protease-1 (Na-APR-1 (M74)) is currently under development by the Sabin Vaccine Institute Product Development Partnership (Sabin PDP). Both monovalent vaccines are currently in Phase 1 trials. Both Na-GST-1 and Na-APR-1 antigens are expressed as recombinant proteins. While Na-GST-1 was found to express with high yields in Pichia pastoris, the level of expression of Na-APR-1 in this host was too low to be suitable for a manufacturing process. When the tobacco plant Nicotiana benthamiana was evaluated as an expression system, acceptable levels of solubility, yield, and stability were attained. Observed expression levels of Na-APR-1 (M74) using this system are ∼300 mg/kg. Here we describe the achievements and obstacles encountered during process development as well as characterization and stability of the purified Na-APR-1 (M74) protein and formulated vaccine. The expression, purification and analysis of purified Na-APR-1 (M74) protein obtained from representative 5 kg reproducibility runs performed to qualify the Na-APR-1 (M74) production process is also presented. This process has been successfully transferred to a pilot plant and a 50 kg scale manufacturing campaign under current Good Manufacturing Practice (cGMP) has been performed. The 50 kg run has provided a sufficient amount of protein to support the ongoing hookworm vaccine development program of the Sabin PDP.

Extended station blackout analyses of an APR1400 with MARS-KS

Directory of Open Access Journals (Sweden)

Kim Woongbae

2016-01-01

Full Text Available The Fukushima Daiichi nuclear power plant accident shows that natural disasters such as earthquakes and the subsequent tsunamis can cause station blackout for several days. The electric energy required for essential systems during a station blackout is provided from emergency backup batteries installed at the nuclear power plant. In South Korea, in the event of an extended station blackout, the life of these emergency backup batteries has recently been extended from 8 hours to 24 hours at Shin-Kori 5, 6, and APR1400 for design certification. For a battery life of 24 hours, available safety means system, equipment and procedures are studied and analyzed in their ability to cope with an extended station blackout. A sensitivity study of reactor coolant pump seal leakage is performed to verify how different seal leakages could affect the system. For simulating extended station blackout scenarios, the best estimate MARS-KS computer code was used. In this paper, an APR1400 RELAP5 input deck was developed for station blackout scenario to analyze operation strategy by manually depressurizing the reactor coolant system through the steam generator's secondary side. Additionally, a sensitivity study on reactor coolant pump seal leakage was carried out.

Evaluation of Ablation rate by the change of Sacrificial Material for PECS in EU-APR

Energy Technology Data Exchange (ETDEWEB)

Hwang, Do Hyun; Kim, Yong Soo; Lee, Keun Sung [KHNP-CRI, Daejeon (Korea, Republic of)

2015-05-15

EU-APR, modified and improved from its original design of APR1400, has been developed to comply with European Utility Requirements (EUR) and nuclear design requirements of the European countries. In EU-APR, Severe Accident Mitigation Systems are dedicated to providing an independent defense line from that of Engineered Safety Feature (ESF) and Diverse Safety Feature (DSF). They consist of Emergency Reactor Depressurization System (ERDS), Passive Ex-vessel corium retaining and Cooling System (PECS), Severe Accident Containment Spray System (SACSS), Hydrogen Mitigation System (HMS) and Containment Filtered Vent System (CFVS). The PECS, so called core catcher, was introduced to prevent the Molten Core Concrete Interaction (MCCI) after Reactor Vessel (RV) failure. The PECS has experienced a lot of changes from its original design. Recently, the most significant change was that as a SM, limestone concrete is installed on PECS's body wall instead of previous sacrificial material rich in Fe{sub 2}O{sub 3}. The main reason of this design change is to overcome the issue that the sacrificial material is ablated rather too fast when reacting with corium that contains a large fraction of Zr metal. Other changes in the geometry of PECS's wall and downcomer design are considered as minor ones. In this paper, the comparison of ablation rates between previous SM and limestone concrete is carried out using MAAP5 code with respective MCCI model according to the material. In this paper, major improvements of MAAP5 model for PECS in EU-APR are presented and the evaluation of ablation rate for the previous SM model and the new LC model is carried out by means of ablation depths with LBLOCA sequence. Two models have respective unique ablation process. The ablation of LC model proceeds at a constant rate regardless of water while the ablation of SM model proceeds at a faster rate before the arrival of cooling water for corium and SM mixture. The change of sacrificial material

Case series

African Journals Online (AJOL)

ebutamanya

28 août 2015 ... Les tumeurs de l'enfant sont dominées par les tumeurs du blastème, les lymphomes et les sarcomes. Ces derniers peuvent se présenter sous forme de tumeurs à petites cellules rondes [1]. La biopsie radioguidée percutanée joue un rôle de plus en plus croissant dans le diagnostic et la prise en charge.

LE CARCINOME MUCOÉPIDERMOÏDE DE LA PAROTIDE : A ...

African Journals Online (AJOL)

16 juin 2006 ... INTRODUCTION. Le carcinome mucoépidermoïde représente 1 à 4% de l'en- semble des tumeurs parotidiennes. Il s'agit de la tumeur maligne la plus fréquente de la glande parotide. Il peut être observé à tout âge avec une égalité entre les 2 sexes. Il s'agit d'une tumeur à croissance lente avec une ...

Optimisation des propriétés pharmacologiques des substances naturelles par la méthode numérique Volsurf

Directory of Open Access Journals (Sweden)

S. DJEDDI

2015-03-01

Full Text Available L'expérience a montré que le maintien de la richesse de la biodiversité végétale ainsi que la connaissance des thérapeutiques traditionnelles, sont susceptibles de mener à bien la recherche de nouvelles molécules aux activités biologiques. Dans ce contexte nous nous sommes intéressés à étudier de manière approfondie l'extraction et l'identification des substances secondaires actives isolées de Centaurea pullata L. (Asteraceae utilisée en médecine traditionnelle algérienne récoltée à Blida. Après l'identification des différentes substances secondaires (huiles essentielles, flavonoïdes, sesquiterpènes lactones, les substances nouvelles isolée et identifiées ont été investiguées pour leurs pouvoirs antimicrobiens (antibactérien et antifongique et anticancéreux. Sachant que les propriétés clefs pour la découverte des médicaments sont l'absorption, la distribution, le métabolisme et l'excrétion (ADME, nous avons alors réalisé la prédiction des propriétés pharmacologiques de quelques substances nouvelles via la méthode computationnelle Volsurf.

Outcomes of patients with abdominoperineal resection (APR) and low anterior resection (LAR) who had very low rectal cancer.

Science.gov (United States)

Yeom, Seung-Seop; Park, In Ja; Jung, Sung Woo; Oh, Se Heon; Lee, Jong Lyul; Yoon, Yong Sik; Kim, Chan Wook; Lim, Seok-Byung; Kim, Nayoung; Yu, Chang Sik; Kim, Jin Cheon

2017-10-01

We compared the oncological outcomes of sphincter-saving resection (SSR) and abdominoperineal resection (APR) in 409 consecutive patients with very low rectal cancer (i.e., tumors within 3 cm from the anal verge); 335 (81.9%) patients underwent APR and 74 (18.1%) underwent SSR. The APR group comprised higher proportions of men (67.5% vs 55.4%, P = .049) and advanced-stage patients (P cancer stages. RFS was associated with ypT and ypN stages in patients who received PCRT, while pN stage, lymphovascular invasion (LVI), and circumferential resection margin (CRM) involvement were risk factors for RFS in those who did not receive PCRT. Notably, SSR was not found to be a risk factor for RFS in either subgroup. Patients who were stratified according to cancer stage and PCRT also showed no differences in RFS according to the mode of surgery. Our results demonstrate that, regardless of PCRT administration, SSR is an effective treatment for very low rectal cancer, while CRM is an important prognostic factor for patients who did not receive PCRT.

Development of phenomena identification and ranking table for APR1400 main steam line break

International Nuclear Information System (INIS)

Song, J. H.; Chung, B. D.; Jeong, J. J.

2003-01-01

A Phenomena Identification and Ranking Table (PIRT) was developed for the Main Steam Line Break (MSLB) event of an APR-1400 (Advanced Power Reactor-1400). A team of experts from research institutes, industries, and regulatory bodies participated in the development. The selected event was a double-ended steam line break at full power with the reactor coolant pump running. The panel selected the fuel performance as the primary safety criterion for ranking. The plant design data, the results of APR-1400 safety analysis, and the results of additional best estimate analysis by MARS2.1 were utilized. Three phases of pre-trip, rapid cool-down, and safety injection phase were identified. Then, the ranking of a system, components, phenomenon/process based on the relative importance to the primary evaluation criterion were followed for each time phase. Finally, the knowledge-level for each important process in the component was ranked in terms of the existing knowledge. The highly ranked phenomena identified for APR-1400 MSLB are tube wall heat transfer at the steam generator shell, void distribution at the steam generator shell, liquid entrainment in the separators, mixture level in the separators, boron mixing in the upper down comer, boron transport and thermal mixing in the lower plenum, stored energy release in the upper head, and flow to and/from the upper head. The PIRT will be used as a guide in planning cost effective experimental programs and code development efforts, especially for the quantification of the process and/or phenomena, which have a high importance but low knowledge level

Evaluation of Coolant Injection Procedure in the Severe Accident Management Strategy of APR1400

International Nuclear Information System (INIS)

Cho, Yongjin; Lim, Kukhee; Song, Sungchu; Lee, Sukho; Hwang, Taesuk

2013-01-01

A coolant injection strategy in the severe accident management guideline (SAMG) of APR1400 relates to immediate coolant injection into RCS (Reactor Coolant System) or injection following the recovery of secondary coolant inventory. This strategy could play important role in accident mitigation and radiological consequences. In this study, appropriateness of the strategy was evaluated using MELCOR1.8.6 and several sensitivity studies of the key parameters were performed. Analysis for APR1400 using MELCOR 1.8.6 was performed to evaluate the effectiveness of accident management strategies and the following conclusions were identified. Sequential operation of secondary and RCS injection may not be the best strategy and the simultaneous injection of secondary and RCS injection could be more preferable. At least, the RCS injection should start before complete drainage of water in the safety injection tank using mobile pumps. In this study, the effectiveness of timing of operator action has been examined and the amount of injection flowrate needs to be studied in the future

Simplified study for the proposed APR1400 condenser performance based on EL-DABAA SITE, EGYPT, with respect to BNPP and SHIN KORI NPP

Energy Technology Data Exchange (ETDEWEB)

Abdoelatef, M. Gomaa; Rezk, Osama; Lee, YonKwan [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2015-10-15

• Perception of nuclear power as a convenient, economically competitive and viable source of energy which, if introduced in the country, would not only complement the traditional energy sources, but would also promote technological development and serve as an incentive for social and economic progress. In this paper we will introduce APR-1400 as the most likely selected reactor type for 1st Egyptian Nuclear Power Plant. Then we will study the optimized APR-1400 condenser performance based on El-Dabaa site conditions. As the climate conditions, especially the seawater temperatures (intake for the cooling system) having a direct effects on the condenser performance and the overall NPP Efficiency, we studied the seawater temperature change based on EL-Dabaa site conditions and it's feedback on the proposed APR-1400 condenser performance and the NPP efficiency. All of the calculations and analysis had been executed by using KINGS NPA by applying EL-Dabaa seawater temperature variations for the 2 types of APR-1400 Condensers (Shinkori, south Korea and Barakah, UAE), and the main findings were as follow: For the APR-1400 condensers (Shinkori and Barakah) performance • The average difference all over the year for saturation temperature, cooling water outlet temperature, and condenser pressure are 0.135 .deg. C, .05785 .deg. C, and 0.3948 mHgA respectively. This shows that the Barakah condenser performance is not significantly better than the shinkori condenser performance based on EL-Dabaa Conditions, especially if we considered the cost difference between the two condensers designs. For APR-1400 NPPs (Shinkori and Barakah) net efficiency • The average difference all over the year for the power productions and net efficiency are 1.4791 MWe and .00037 %, respectively.

Using a Classroom Response System to Improve Multiple-Choice Performance in AP[R] Physics

Science.gov (United States)

Bertrand, Peggy

2009-01-01

Participation in rigorous high school courses such as Advanced Placement (AP[R]) Physics increases the likelihood of college success, especially for students who are traditionally underserved. Tackling difficult multiple-choice exams should be part of any AP program because well-constructed multiple-choice questions, such as those on AP exams and…

Analysis of Turbine Load Rejection for APR1400 using SPACE

Energy Technology Data Exchange (ETDEWEB)

Kim, Sang Jin; Park, Chan Eok; Choi, Jong Ho; Lee, Gyu Cheon [KEPCO Engineering and Construction Co. Ltd., Deajeon (Korea, Republic of)

2016-10-15

Turbine Load Rejection event is one of the Performance Related Design Basis Event (PRDBE) that can be stabilized using plant control systems without any safety system actuation. The initiation of the event is turbine load rejection from 100% to 5% in 0.019 seconds. The NSSS control systems of APR1400 is composed of the Power Control System (PCS) and the Process-Component Control System (P-CCS). The PCS includes Reactor Regulating System (RRS), Reactor Power Cutback System (RPCS) and Digital Rod Control System (DRCS). The P-CCS includes the Pressurizer Pressure Control System (PPCS), the Pressurizer Level Control System (PLCS), the Feedwater Control System (FWCS) and the Steam Bypass Control System (SBCS). Turbine load rejection results in the increase of secondary pressure due to sudden blocking of steam flow to turbine. Then the Reactor Coolant System (RCS) cooling through steam generators is decreased rapidly and the RCS temperature will be increased. Turbine load rejection is a typical event to test NSSS control systems since it requires the automatic response of all major NSSS control systems. It is shown that the NSSS control systems of APR1400 have the capability to stabilize the plant without any safety system actuation for turbine load rejection event. This analysis results show that SPACE code has the capability to analyze the turbine load rejection event. However, further validation is necessary for other PRDBEs such as Two Main Feedwater Pumps Trip, Turbine Load Step Change and Turbine Load Ramp Down (5%/min) to verify the capability of SPACE for the full range of performance analyses.

Analysis of Turbine Load Rejection for APR1400 using SPACE

International Nuclear Information System (INIS)

Kim, Sang Jin; Park, Chan Eok; Choi, Jong Ho; Lee, Gyu Cheon

2016-01-01

Turbine Load Rejection event is one of the Performance Related Design Basis Event (PRDBE) that can be stabilized using plant control systems without any safety system actuation. The initiation of the event is turbine load rejection from 100% to 5% in 0.019 seconds. The NSSS control systems of APR1400 is composed of the Power Control System (PCS) and the Process-Component Control System (P-CCS). The PCS includes Reactor Regulating System (RRS), Reactor Power Cutback System (RPCS) and Digital Rod Control System (DRCS). The P-CCS includes the Pressurizer Pressure Control System (PPCS), the Pressurizer Level Control System (PLCS), the Feedwater Control System (FWCS) and the Steam Bypass Control System (SBCS). Turbine load rejection results in the increase of secondary pressure due to sudden blocking of steam flow to turbine. Then the Reactor Coolant System (RCS) cooling through steam generators is decreased rapidly and the RCS temperature will be increased. Turbine load rejection is a typical event to test NSSS control systems since it requires the automatic response of all major NSSS control systems. It is shown that the NSSS control systems of APR1400 have the capability to stabilize the plant without any safety system actuation for turbine load rejection event. This analysis results show that SPACE code has the capability to analyze the turbine load rejection event. However, further validation is necessary for other PRDBEs such as Two Main Feedwater Pumps Trip, Turbine Load Step Change and Turbine Load Ramp Down (5%/min) to verify the capability of SPACE for the full range of performance analyses

PLUS 7TM advanced fuel assembly development program for KSNPs and APR1400

International Nuclear Information System (INIS)

Kim, Kyutae; Stucker, David L.

2002-01-01

KNFC and Westinghouse have recently completed the development of the PLUS 7 TM advanced 16 X 16 fuel assembly for the Korean Standard Nuclear Plants (KSNPs) and the Advanced Power Reactor 1400 (APR 1400). This fuel design utilized the proven advanced design features including mixing vane spacer grids to increase critical heat flux performance, ZIRLO TM advanced materials to enable high-duty, high burnup fuel management and an optimized fuel rod diameter which improves fuel cycle cost while resulting in significant standardization of Korean fuel manufacture. PLUS 7 TM , also includes a patented spacer grid design with conformal fuel rod support designed to provide superior fuel rod wear/fretting resistance while minimizing pressure drop. This paper will present an overview of the PLUS 7 TM fuel assembly development process including a summary of the three-year design and testing program from a mechanical, neutronic, and thermal/hydraulic perspective. The PLUS 7 TM fuel for the KSNPs and the APR1400 reactors results in multi-million dollar per cycle savings in imported enriched uranium product for the Korean nuclear power program with technology specifically developed for Korea by experienced Korean engineers

A Study on the Embedment Effect in the Soil-Structure Interaction Analysis of the APR1400

International Nuclear Information System (INIS)

Young-Sun Jang; Kwang-Ho Joo; Chong-Hak Kim

2002-01-01

The SSI (Soil-Structure Interaction) analyses are being performed for the APR1400 (Advanced Power Reactor 1400 MWe, Old name - KNGR; Korean Next Generation Reactor) design, because the APR1400 is developed as a Standard Nuclear Power Plant concept enveloping suitable soil conditions. For the SSI analyses, SASSI program which adopts the Flexible Volume Method is used. In the SSI analyses, there can be uncertainties by Bond and De-bond problem between the structure and lateral soil elements. According to ASCE Standard 4, one method to address this concern is to assume no connectivity between structure and lateral soil over the upper half of the embedment of 20 ft (6 m), whichever is less. This study is performed as a part of the parametric analyses for the APR1400 seismic analyses to address the concern of the potential embedment effect on the in-structure response spectra due to connectivity between structure and lateral soil. In this study, 4 model cases are analyzed to check the potential embedment effect - Full connection, 20 ft no connectivity which is defined as a minimum De-bond depth of the soil in ASCE Standard 4 and 26.5 ft no connectivity between structure and lateral soil over the upper half of the embedment. Last one is full no connection for only reference. The in-structure response spectra are compared with the response spectra without considering the embedment effect. (authors)

Evaluation Methodology for Void Swelling Susceptibility of APR1400 Reactor Vessel Internals for U.S. NRC Design Certification

Energy Technology Data Exchange (ETDEWEB)

Kweon, Hyeong Do; Lee, Do Hwan [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

The APR1400 RVI (Reactor Vessel Internals) operates in harsh conditions, such as long term exposure to neutron irradiation, high temperatures, reactor coolant environment, and other operating loads. Therefore, even though the RVI components are mainly made of austenitic stainless steel which is well known to have good mechanical and corrosion-resistive properties, these operating conditions. The aging is characterized by a chromium depletion along grain boundaries of austenitic stainless steel, a decrease in ductility and fracture toughness of the steel, an increase in yield and ultimate strength of the steel, and a potential volume change due to void formation in the steel. For these reasons, under certain conditions of stress, temperature, and level of irradiation, the void swelling which is one of the challenging degradation mechanisms affecting the integrity of the RVI may appear at specific locations of the RVI, especially due to high neutron fluence and high temperature under localized gamma heating and low velocity of coolant flow. To assess the effects of operating neutron fluences, temperatures and stresses on the material properties changes and the susceptibility to the void swelling, the evaluation methodology of the APR1400 RVI components for U.S. NRC Design Certification was suggested in this paper. The approach to the evaluation is summarized as follows: 1. RVI component list of the APR1400 is collected. 2. Initial screening to determine the evaluation scope is completed using the design values of fluences. 3. Functionality assessments (radiation transport analysis, CFD analysis, structural analysis) are sequentially performed. 4. Susceptibility to the void swelling is identified through ANSYS/USERMAT module. KHNP believes that the proposed methodology which is based on the EPRI works for operating reactors is the best way to evaluate the void swelling for new reactors such as the APR1400.

Cloned Bacillus subtilis alkaline protease (aprA) gene showing high level of keratinolytic activity.

Science.gov (United States)

Zaghloul, T I

1998-01-01

The Bacillus subtilis alkaline protease(aprA) gene was previously cloned on a pUBHO-derivative plasmid. High levels of expression and gene stability were demonstrated when B. subtilis cells were grown on the laboratory medium 2XSG. B. subtilis cells harboring the multicopy aprA gene were grown on basal medium, supplemented with 1 % chicken feather as a source of energy, carbon, and nitrogen. Proteolytic and keratinolytic activities were monitored throughout the cultivation time. A high level of keratinolytic activity was obtained, and this indicates that alkaline protease is acting as a keratinase. Furthermore, considerable amounts of soluble proteins and free amino acids were obtained as a result of the enzymatic hydrolysis of feather. Biodegradation of feather waste using these cells represents an alternative way to improve the nutritional value of feather, since feather waste is currently utilized on a limited basis as a dietary protein supplement for animal feedstuffs. Moreover, the release of free amino acids from feather and the secreted keratinase enzyme would promote industries based on feather waste.

Constructibility assessment of APR1400

International Nuclear Information System (INIS)

Cho, Sung Jae; Kang, Yong Chul; Lee, Jae Gon; Lim, Woo Sang

2003-01-01

APR1400 (formerly KNGR) development is one of national G-7 projects sponsored by government and KHNP (Korea Hydro and Nuclear Power Co., LTD). It is an evolutionary standard reactor with the thermal output of 4000MWt and has been adopted for Shin-Kori Unit 3 and 4. The government organizations, research institutes, universities and industries have participated in the project since 1992 along with KHNP, and the standard design certification program was issued in May 2002. The project set up the top-tier requirements about the safety, economy, operability and maintainability, and constructibility in the early design stage. The requirements have been evaluated periodically during the design process, and the results were reflected to the design. This paper describes the methods for constructibility enhancement and the results of schedule analysis to assure meeting construction duration target, which is set to 48 months from the first concrete pouring to the commercial operation on the condition that learning effects are maximized at Nth plant. To meet the target schedule, the design characteristics and constructibility studies such as new construction methods and construction schedule analysis were performed. The new construction methods presented here are over the top method for NSSS components, deck plate and steel from for concrete wall and slab, automatic welding for large bore piping, and modularization of components and structure, etc. (author)

Analysis of Total Loss of Feedwater for APR1400 using SPACE

Energy Technology Data Exchange (ETDEWEB)

Hong, Seong Min; Park, Seok Jeong; Park, Chan Eok; Choi, Jong Ho; Lee, Gyu Cheon [KEPCO Engineering and Construction, Deajeon (Korea, Republic of)

2016-10-15

The Total Loss of FeedWater (TLOFW) event is an accident that main feedwater and auxiliary feedwater of secondary side are not supplied to steam generators. APR1400 uses the Safety Depressurization and Vent System (SDVS) for the F and B operation and SDVS is designed to perform the rapid depressurization function of Reactor Coolant System (RCS) through the remote manual operation when TLOFW is occurred. If RCS pressure falls below a Safety Injection Pump (SIP) working pressure, it can be possible to start the F and B operation which injects SIP flow to RCS and releases the RCS vapor and two-phase flow through Pilot Operated Safety Relief Valves (POSRVs) by opening the POSRVs, and then it can be possible to remove the decay heat. The design requirement of SDVS is that the core water level should be maintained at higher than 2 feet from the top of active core during the F and B operation. The TLOFW analysis was carried out to evaluate the capability of decay heat removal for APR1400 using newly developed SPACE code. The analysis results show that the F and B operation with 2 POSRVs and 2 SIPs and the F and B operation with 4 POSRVs and 4 SIPs meet the SDVS design requirement for the fuel cladding temperature. The comparison with RELAP5 shows good agreement and it validates the applicability of SPACE code for this type of accident analysis.

Single port-assisted fully laparoscopic abdominoperineal resection (APR) with immediate V-RAM flap reconstruction of the perineal defect.

LENUS (Irish Health Repository)

Ali, Sayid

2012-09-01

Abdominoperineal resection (APR) of anorectal cancers after neoadjuvant chemoradiotherapy may incur significant perineal morbidity. While vertical rectus abdominis muscle (V-RAM) flaps can fill the pelvic resection space with health tissue, their use has previously been described predominantly in association with laparotomy. Here, we describe a means of combination laparoscopic APR with V-RAM flap reconstruction that allows structural preservation of the entire abdominal wall throughout the oncological resection and of the deep parietal layers after V-RAM donation. Furthermore, a single port access device used at the end colostomy site allows a second senior surgeon assist with an additional two working instruments for the purpose of improved pelvic tissue retraction, especially useful in obese patients.

Des recommandations probantes pour surveiller l’innocuité des antipsychotiques de deuxième génération chez les enfants et les adolescents

Science.gov (United States)

Pringsheim, Tamara; Panagiotopoulos, Constadina; Davidson, Jana; Ho, Josephine

2012-01-01

HISTORIQUE : Au Canada, l’utilisation d’antipsychotiques, notamment les antipsychotiques de deuxième génération (ADG), a augmenté de façon considérable depuis cinq ans chez les enfants ayant des troubles de santé mentale. Ces médicaments ont le potentiel de causer de graves complications métaboliques et neurologiques lorsqu’on les utilise de manière chronique. OBJECTIF : Synthétiser les données probantes relatives aux effets secondaires métaboliques et neurologiques précis associés à l’usage d’ADG chez les enfants et fournir des recommandations probantes sur la surveillance de ces effets secondaires. MÉTHODOLOGIE : Les auteurs ont procédé à une analyse systématique des essais cliniques contrôlés des ADG auprès d’enfants. Ils ont fait des recommandations à l’égard de la surveillance de l’innocuité des ADG d’après un modèle de classification fondé sur le système GRADE (système de notation de l’évaluation et de l’élaboration des recommandations). Lorsque les données probantes n’étaient pas suffisantes, ils fondaient leurs recommandations sur le consensus et l’avis d’experts. Un groupe consensuel multidisciplinaire a analysé toutes les données probantes pertinentes et est parvenu à un consensus à l’égard des recommandations. RÉSULTATS : Les recommandations probantes portant sur la surveillance de l’innocuité des ADG figurent dans les présentes lignes directrices. Les auteurs indiquent la qualité des recommandations relatives à des examens physiques et tests de laboratoire précis à l’égard de chaque ADG à des moments déterminés. CONCLUSION : De multiples essais aléatoires et contrôlés ont permis d’évaluer l’efficacité de bon nombre des ADG utilisés pour traiter les troubles de santé mentale en pédiatrie. Toutefois, leurs avantages ne sont pas sans risques : on observe à la fois des effets secondaires métaboliques et neurologiques chez les enfants traités au moyen d�

Diversity of sulfur-cycle prokaryotes in freshwater lake sediments investigated using aprA as the functional marker gene.

Science.gov (United States)

Watanabe, Tomohiro; Kojima, Hisaya; Takano, Yoshinori; Fukui, Manabu

2013-09-01

The diversity of sulfate-reducing prokaryotes (SRPs) and sulfur-oxidizing prokaryotes (SOPs) in freshwater lake ecosystems was investigated by cloning and sequencing of the aprA gene, which encodes for a key enzyme in dissimilatory sulfate reduction and sulfur oxidation. To understand their diversity better, the spatial distribution of aprA genes was investigated in sediments collected from six geographically distant lakes in Antarctica and Japan, including a hypersaline lake for comparison. The microbial community compositions of freshwater sediments and a hypersaline sediment showed notable differences. The clones affiliated with Desulfobacteraceae and Desulfobulbaceae were frequently detected in all freshwater lake sediments. The SOP community was mainly composed of four major phylogenetic groups. One of them formed a monophyletic cluster with a sulfur-oxidizing betaproteobacterium, Sulfuricella denitrificans, but the others were not assigned to specific genera. In addition, the AprA sequences, which were not clearly affiliated to either SRP or SOP lineages, dominated the libraries from four freshwater lake sediments. The results showed the wide distribution of some sulfur-cycle prokaryotes across geographical distances and supported the idea that metabolic flexibility is an important feature for SRP survival in low-sulfate environments. Copyright © 2013 Elsevier GmbH. All rights reserved.

Precificação de consultoria empresarial com a contribuição das estratégias de apreçamento = Entrepreneurial Counseling Pricing with Pricing Strategy Contribution

Directory of Open Access Journals (Sweden)

Nivaldo João dos Santos

2008-11-01

Full Text Available A precificação de serviços de consultoria também pode se beneficiar dos conceitos e idéias das estratégias de apreçamento de bens de consumo de massa, especificamente na área de consultoria de gestão empresarial. Apesar deste campo ser dominado por grandes corporações multinacionais, ainda existe espaço para empresas e profissionais nacionais. Por se tratar de mercado que envolve valores de grande magnitude, imaginasse que as instituições de sucesso adotem estratégia de apreçamento. Neste trabalho, estratégias de apreçamento foram selecionadas para exame e verificação de aplicabilidade quando do estabelecimento valor pelos serviços da consultoria de gestão empresarial. O apreçamento de desnatação, apreçamento de penetração, apreçamento neutro e apreçamento baseado em valor tiveram seus conceitos sintetizados para fins de verificação. O apreçamento baseado em valor se revelou o mais propício para este tipo de produto (consultoria e o processo de comunicação é o elemento crítico para evidenciar valor, benefícios e, finalmente, justificar o preço do serviço. A sugestão de roteiro para apreçamento de serviço de consultoria empresarial é apresentada ao final, como resultado da análise das diversas estratégias de apreçamento.The pricing of counseling services may also benefit from strategy concepts and ideas ofmass consumption goods pricing, specifically within the entrepreneurial managementcounseling area. Even though this field has been taken over by big multinationalcorporations, there is still some space for national enterprisings and professionals. As itis a market that involves values of great magnitude, it is thought that successfulinstitutions adopt this pricing strategy. In this study, pricing strategies were selectedfor analysis and applicability checking by the time the price for entrepreneurialmanagement counseling service was established. The skimming pricing, penetratingpricing, neutral

A Quantitative Feasibility Study on Potential Safety Improvement Effects of Advanced Safety Features in APR-1400 when Applied to OPR-1000

Energy Technology Data Exchange (ETDEWEB)

Ualikhan Zhiyenbayev [KAIST, Daejeon (Korea, Republic of); Chung, Dae Wook [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2015-10-15

This study aims to test the feasibility of the applications using Probabilistic Safety Assessment (PSA). Particularly, three of those advanced safety features are selected as follows: 1. Providing an additional Emergency Diesel Generator (EDG); 2. Increasing the capacity of Class 1E batteries; 3. Placing a Refueling Water Storage Tank (RWST) inside containment, i.e., change from RWST to IRWST. The Advanced Power Reactor 1400 (APR-1400) adopts several advanced safety features compared to its predecessor, the Optimized Power Reactor 1000 (OPR-1000), which includes an additional Emergency Diesel Generator, increase in battery capacity, in-containment refueling water storage tank (IRWST), and so on. Considering the remarkable advantages of these safety features in safety improvement and the design similarities between APR-1400 and OPR-1000, it is feasible to apply key advanced safety features of APR-1400 to OPR-1000 to enhance the safety. The selected safety features are incorporated into OPR-1000 PSA model using the Advanced Information Management System (AIMS) for PSA and CDFs are re-evaluated for each application and combination of three applications. Based on current results, it is concluded that three of key advanced safety features of APR-1400 can be effectively applied to OPR-1000, resulting in considerable safety improvement. In aggregate, three advanced safety features, which are an additional EDG, increased battery capacity and IRWST, can reduce the CDF of OPR-1000 by more than 15% when applied altogether.

A Quantitative Feasibility Study on Potential Safety Improvement Effects of Advanced Safety Features in APR-1400 when Applied to OPR-1000

International Nuclear Information System (INIS)

Ualikhan Zhiyenbayev; Chung, Dae Wook

2015-01-01

This study aims to test the feasibility of the applications using Probabilistic Safety Assessment (PSA). Particularly, three of those advanced safety features are selected as follows: 1. Providing an additional Emergency Diesel Generator (EDG); 2. Increasing the capacity of Class 1E batteries; 3. Placing a Refueling Water Storage Tank (RWST) inside containment, i.e., change from RWST to IRWST. The Advanced Power Reactor 1400 (APR-1400) adopts several advanced safety features compared to its predecessor, the Optimized Power Reactor 1000 (OPR-1000), which includes an additional Emergency Diesel Generator, increase in battery capacity, in-containment refueling water storage tank (IRWST), and so on. Considering the remarkable advantages of these safety features in safety improvement and the design similarities between APR-1400 and OPR-1000, it is feasible to apply key advanced safety features of APR-1400 to OPR-1000 to enhance the safety. The selected safety features are incorporated into OPR-1000 PSA model using the Advanced Information Management System (AIMS) for PSA and CDFs are re-evaluated for each application and combination of three applications. Based on current results, it is concluded that three of key advanced safety features of APR-1400 can be effectively applied to OPR-1000, resulting in considerable safety improvement. In aggregate, three advanced safety features, which are an additional EDG, increased battery capacity and IRWST, can reduce the CDF of OPR-1000 by more than 15% when applied altogether

Liposarcome dorsal: aspect clinique rare

Science.gov (United States)

Agbessi, Odry; Arrob, Adil; Fiqhi, Kamal; Khalfi, Lahcen; Nassih, Mohammed; El Khatib, Karim

2015-01-01

Décrit la première fois par Virchow en 1860, le liposarcome est une tumeur mésenchymateuse rare. Cette rareté est relative car les liposarcomes représentent quand même 14 à 18% de l'ensemble des tumeurs malignes des parties molles et ils constituent le plus fréquent des sarcomes des parties molles. Pour la majorité des auteurs, il ne se développerait jamais sur un lipome ou une lipomatose préexistant. Nous rapportons un cas de volumineux liposarcome de la face dorsale du tronc. L'histoire de la maladie, l'aspect clinique inhabituel « de tumeur dans tumeur », l'aspect de la pièce opératoire nous fait évoquer la possibilité de la transformation maligne d'un lipome bénin préexistant. PMID:26113914

Probability of Neutralization Estimation for APR1400 Physical Protection System Design Effectiveness Evaluation

Energy Technology Data Exchange (ETDEWEB)

Kim, Myungsu; Lim, Heoksoon; Na, Janghwan; Chi, Moongoo [Korea Hydro and Nuclear Power Co. Ltd. Central Research Institute, Daejeon (Korea, Republic of)

2015-05-15

It is focusing on development of a new designing process which can be compatible to international standards such as IAEA1 and NRC2 suggest. Evaluation for the design effectiveness was found as one of the areas to improve. If a design doesn't meet a certain level of effectiveness, it should be re-designed accordingly. The effectiveness can be calculated with combination of probability of Interruption and probability of neutralization. System Analysis of Vulnerability to Intrusion (SAVI) has been developed by Sandia National Laboratories for that purpose. With SNL's timely detection methodology, SAVI has been used by U.S. nuclear utilities to meet the NRC requirements for PPS design effectiveness evaluation. For the SAVI calculation, probability of neutralization is a vital input element that must be supplied. This paper describes the elements to consider for neutralization, probability estimation methodology, and the estimation for APR1400 PPS design effectiveness evaluation process. Markov chain and Monte Carlo simulation are often used for simple numerical calculation to estimate P{sub N}. The results from both methods are not always identical even for the same situation. P{sub N} values for APR1400 evaluation were calculated based on Markov chain method and modified to be applicable for guards/adversaries ratio based analysis.

Review of EU-APR Design for Selected Safety Issues of WERNA RHWG 2013

Energy Technology Data Exchange (ETDEWEB)

Kim, Yong Soo; Kim, Ji Hwan [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

Western European Nuclear Regulators' Association (WENRA) was established in 1999 to develop a harmonized approach to nuclear safety and radiation protection and their regulation. In 2013, the Reactor Harmonization Working Group (RHWG) of WENRA sets out the common positions on the seven selected key safety issues. This paper is to introduce the regulatory positions of WENRA RHWG 2013 and to review the compliance of the EU-APR with them. In this paper, we reviewed the compliance of the EUAPR regarding seven safety issues for new NPPs presented by WERNA RHWG in 2013. The EU-APR design fully complies with all WERNA RHWG safety issues since the following measures have been incorporated in it: - Successive five levels of DiD maintaining independence between different levels of DiD - Diverse design against multiple failure events such as ATWS, SBO, Loss of Ultimate Heat Sink, and Loss of Spent Fuel Pool Cooling - SAs dedicated mitigation systems to ensure the containment integrity during the SAs. - Practically eliminates accident sequences with a large or early release of radiological materials by diverse designs for multiple failure events, SAs dedicated mitigation system, and double containment design - Standard site parameters not lead to core melt accidents due to natural or man-made external hazards.

Real-time PCR quantification and diversity analysis of the functional genes aprA and dsrA of sulfate-reducing bacteria in marine sediments of the Peru continental margin and the Black Sea

Directory of Open Access Journals (Sweden)

Axel eSchippers

2011-12-01

Full Text Available A quantitative, real-time PCR (Q-PCR assay for the functional gene adenosine 5´-phosphosulfate reductase (aprA of sulfate-reducing bacteria (SRB was designed. This assay was applied together with described Q-PCR assays for dissimilatory sulfite reductase (dsrA and the 16S rRNA gene of total Bacteria to marine sediments from the Peru margin (0 – 121 meters below seafloor (mbsf and the Black Sea (0 – 6 mbsf. Clone libraries of aprA show that all isolated sequences originate from SRB showing a close relationship to aprA of characterised species or form a new cluster with only distant relation to aprA of isolated SRB. Below 40 mbsf no aprA genes could be amplified. This finding corresponds with results of the applied new Q-PCR assay for aprA. In contrast to the aprA the dsrA gene could be amplified up to sediment depths of 121 mbsf. Even in such an extreme environment a high diversity of this gene was detected. The 16S rRNA gene copy numbers of total Bacteria were much higher than those of the functional genes at all sediment depths and used to calculate the proportion of SRB to the total Bacteria. The aprA and dsrA copy numbers comprised in average 0.5 - 1 % of the 16S rRNA gene copy numbers of total Bacteria in the sediments up to a depth of ca. 40 mbsf. Depth profiles of the aprA and dsrA copy numbers were almost equal for all sites. Gene copy numbers decreased concomitantly with depth from around 108 / g sediment close to the sediment surface to less than 105 / g sediment at 5 mbsf. In the zone without detectable sulfate in the pore water from ca. 40 – 121 mbsf (Peru margin ODP site 1227, only dsrA (but not aprA was detected with copy numbers of less than 104 / g sediment, comprising ca. 14 % of the 16S rRNA gene copy numbers of total Bacteria. In this zone sulfate might be provided for SRB by anaerobic sulfide oxidation.

Developing Optimal Procedure of Emergency Outside Cooling Water Injection for APR1400 Extended SBO Scenario Using MARS Code

Energy Technology Data Exchange (ETDEWEB)

Hwang, Jong Rok; Oh, Seung Jong [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2013-10-15

In this study, we examined optimum operator actions to mitigate extended SBO using MARS code. Particularly, this paper focuses on analyzing outside core cooling water injection scenario, and aimed to develop optimal extended SBO procedure. Supplying outside emergency cooling water is the key feature of flexible strategy in extended SBO situation. An optimum strategy to maintain core cooling is developed for typical extended SBO. MARS APR1400 best estimate model was used to find optimal procedure. Also RCP seal leakage effect was considered importantly. Recent Fukushima accident shows the importance of mitigation capability against extended SBO scenarios. In Korea, all nuclear power plants incorporated various measures against Fukushima-like events. For APR1400 NPP, outside connectors are installed to inject cooling water using fire trucks or portable pumps. Using these connectors, outside cooling water can be provided to reactor, steam generators (SG), containment spray system, and spent fuel pool. In U. S., similar approach is chosen to provide a diverse and flexible means to prevent fuel damage (core and SFP) in external event conditions resulting in extended loss of AC power and loss of ultimate heat sink. Hence, hardware necessary to cope with extended SBO is already available for APR1400. However, considering the complex and stressful condition encountered by operators during extended SBO, it is important to develop guidelines/procedures to best cope with the event.

Les pratiques littéraciées bidisciplinaires lettres-histoire dans le secondaire : vers la construction d'une culture humaniste moins différenciatrice pour les élèves de milieu populaire ?

Directory of Open Access Journals (Sweden)

Rossignol Marie-France

2015-01-01

Full Text Available Dans le contexte de massification et de multiculturalisme qui caractérise actuellement l'enseignement secondaire français, la nécessité de dispenser une culture commune à donner en partage à tous les élèves se trouve mise sur le devant de la scène scolaire. Les dernières réformes en cours présentent cet objectif comme prioritaire. Ainsi les nouveaux programmes de 2006 réinstitutionnalisent la « culture humaniste », héritière de la culture scolaire originelle, et la confient aux disciplines littéraires, français et histoire, ainsi qu'aux disciplines artistiques. Cette restauration pose la question vive de l'appropriation chez les élèves de milieu populaire d'une telle forme de culture, d'ordre scripturaire, fondée sur la lecture de textes patrimoniaux, en particulier littéraires, mobilisant des ressources cognitives et culturelles de haut niveau. Comment leur donner accès à une littératie humaniste très éloignée de leurs pratiques socioculturelles de référence habituelles sans risquer d'accroître les écarts avec les élèves socialement plus favorisés, davantage familiarisés à cette forme culturelle ? Une recherche exploratoire est menée à partir d'un dispositif bidisciplinaire français-histoire expérimental, mis en œuvre par des praticiens confirmés, dans trois classes d'établissements du secondaire de la banlieue parisienne accueillant des élèves d'origine modeste. L'analyse des productions écrites et orales des élèves montre que la pratique d'une littératie humanisteen contexte bidisciplinaire favorise chez eux l'entrée dans l'apprentissage de la culture humaniste scolaire, et, sur un mode certes très différencié, les conduit à mieux se l'approprier.

Domestic activity for technical development of the APR1400's RCP performance test

Energy Technology Data Exchange (ETDEWEB)

Cho, Seok; Kim, Seok; Bae, Byung-Uhn; Cho, Yun-Jae; Kim, Yeon-Sik; Jeon, Woo-Jin; Yun, Young-Jung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-10-15

The thermal hydraulic and electric capability of the RCP test facility (RCPTF) covers up to 18.5 MPa, 343 .deg. C, 11.7 m{sup 3}/s, and 14.0 MW in the design pressure, temperature, flow rate, and the maximum electric power, respectively. In 2013, commissioning test had been performed to verify its designed capability, followed by several modifications in the RCPTF including signal processing and control logic to enhance verification and evaluation capability of the RCP performance. After finishing the commissioning and modification of the RCPTF, type test for the new-type RCP had been performed successfully. In this paper, several technical issues developed in the 2013 and the type test's method and results will be described. In the present paper, the technical activities for the development of the verification test of APR1400's RCP are described. KAERI has completed the full set of technology development, prerequisite for the RCP verification test, and now on the way to perform a test for the sealing capacity of the seal assembly during the Station Block Out (SBO) condition of APR1400.

Brain Tumour Scintigraphy with {sup 99m}Tc-Pertechnetate, {sup 99m}Tc-Fe(II) Complex and {sup 131}I-Labelled Macroaggregated Albumin - Comparison of Results; La Scintigraphie des Tumeurs Cerebrales a l'Aide de Pertechnetate Marque au {sup 99m}Tc, de Complexe {sup 99m}Tc-Fe-II et de Macroagregats d'Albumine Marques au {sup 131}I. Comparaison des Resultats

Energy Technology Data Exchange (ETDEWEB)

Haas, J. P.; Dietz, H.; Schmidt, K. J.; Doerr, F.; Brod, K. H.; Wolf, R. [Institut de Radiologie Clinique et Clinique de Neurochirurgie, Universite de Mayence, Federal Republic of Germany (Germany)

1969-05-15

from a wide selection of case studies. (author) [French] Aujourd'hui le {sup 99m}Tc, sous forme de pertechnetate, a trouve sa place dans la scintigraphie cerebrale.' Selon les experiences des auteurs du memoire ainsi que celles d'autres auteurs, sa valeur diagnostique est egale a celle des substances marquees au mercure ou a l'iode. Tout en utilisant le pertechnetate marque au {sup 99m}Tc les auteurs ont cherche a elargir le diagnostic isotopique par deux methodes; l'injection intra-arterielle de macro-agregats d'albumine, et l'injection, par voie intraveineuse, d'une nouvelle substance, le complexe {sup 99m}Tc-Fe-II. Les auteurs ont publie en 1966 les resultats obtenus a l'aide de la premiere methode; ils presentent maintenant le bilan de leurs experiences sur un grand nombre de patients, plus de cent, souffrant de tumeurs cerebrales. Comparee a la scintigraphie au pertechnetate marque au {sup 99m}Tc apres injection par voie intraveineuse, la nouvelle methode donne des informations complementaires qui facilitent souvent grandement le diagnostic neuroradiologique clinique. La plupart des cas furent verifies par l'operation ou l'autopsie. La methode donne pour la premiere fois la possibilite de visualiser par la scintigraphie le reseau arteriel du cerveau. Les auteurs ont ete amenes a utiliser la deuxieme methode pour la detection des tumeurs cerebrales en raison de la facilite de mise en oeuvre de la scintigraphie cerebrale apres injection par voie intraveineuse, et parce qu'ils disposaient des resultats d'experiences effectuees avec le complexe {sup 99m}Tc-Fe-H sur la scintigraphie des reins ainsi que d'une breve communication parue dans la litterature americaine. Les premieres experiences montrent que cette substance est nettement superieure a toutes celles qui ont ete utilisees jusqu'ici par voie intraveineuse. Elle unit les avantages incontestables du {sup 99m}Tc, en ce qui concerne surtout la dose d'irradiation du patient, a la nettete extraordinaire de

Monitoring the impact of an aspartic protease (MpAPr1) on grape proteins and wine properties.

Science.gov (United States)

Theron, Louwrens Wiid; Bely, Marina; Divol, Benoit

2018-04-23

The perception of haze in wine is brought about when pathogenesis-related proteins become unstable and aggregate, subsequently resulting in crosslinking until it develops into light-dispersing particles. Elimination of these proteins is usually achieved via bentonite fining, which, although effective, suffers from several drawbacks. The utilization of proteases has been proposed as an ideal alternative. In a previous study, an aspartic protease (MpAPr1) from the yeast Metschnikowia pulcherrima was purified and shown to be partially active against grape proteins in synthetic medium. In this study, the effects of pure MpAPr1 supplemented to Sauvignon Blanc juice on subsequent fermentation were investigated. The juice was incubated for 48 h and thereafter inoculated with Saccharomyces cerevisiae. Results revealed that the enzyme had no observable effects on fermentation performance and retained activity throughout. Protein degradation could be detected and resulted in a significant modification of the wine composition and an increase in the presence of certain volatile compounds, especially those linked to amino acid metabolism.

Numerical Investigation of APR1400 Loop Seal Reformation and Clearing Phenomena during Post-LOCA Long-term Cooling Period using RELAP5

Energy Technology Data Exchange (ETDEWEB)

Lee, S. I.; Jeon, J. H.; Park, J. H.; Sung, H. J.; Lee, J. I.; Choi, T. S. [KEPCO NF, Daejeon (Korea, Republic of)

2016-10-15

Hand calculations had been tried to show that the loop seal reformation does not degrade the LTC performance of the APR1400, but the result was unclear. Therefore, the code assessments of the phenomena for APR1400 are required to guarantee the performance of LTC. In the present study, RELAP5/MOD3.3 patch04 (3.3iy) is used for the assessments. The safety degradation, e.g., possible cladding temperature rise due to LSRC during LTC period would be stronger when the safety injection (SI) is larger, while the core uncovery is more probable when the SI is smaller. In other words, it is not easy to determine the limiting condition of safety injection as two or four safety injection pumps (SIPs) in APR1400. In the present study, both the minimum SI condition with two SIPs and the maximum SI condition with four SIPs are considered. The study focuses only on the top slot break condition due to its highest possibility of LSRC phenomena. The LSRC issues for APR1400 are discussed and investigated through numerical investigation using RELAP5MOD3.3 patch04 for top-slot cold leg (pump discharge line) breaks. The major items investigated are whether the simultaneous four loop seal reformation is possible and whether there is any possible violation of the long term coolability criteria in 10 CFR 50.46. Safety injection with two SIPs and four SIPs are investigated to find that the four loop seal reformation condition before the simultaneous injection may occur only with four SIPs.

A Model of Secondary Hydrocarbon Migration As a Buoyancy-Driven Separate Phase Flow Un modèle de migration secondaire des hydrocarbures considéré comme un écoulement en phases séparées régi par la poussée d'Archimède

Directory of Open Access Journals (Sweden)

Lehner F. K.

2006-11-01

Full Text Available A mathematical model of secondary migration is described which permits the prediction of hydrocarbon migration and accumulation patterns in a sedimentary basin, if source rock expulsion rates and geometrical and hydraulic properties of major carrier systems are known through geological time. In this model, secondary migration is treated as buoyancy-driven, segregated flow of hydrocarbons in hydrostatic aquifers. Lateral, updip migration is conceived as a Boussinesq-type, free-surface flow, with source and sink terms representing supply from source rocks and leakage through cap rocks and faults. This permits a two-dimensional, map-view mathematical description of a three-dimensional, time-dependent secondary migration system. A nine-point finite difference approximation has been developed to minimize numerical dispersion, and upstream-weighting is used to obtain stable solutions. Example computations for simple, single carrier bed structures are presented. L'article décrit un modèle mathématique de migration secondaire prédisant la migration des hydrocarbures et leur accumulation dans un bassin sédimentaire, lorsque les taux d'expulsion des roches mères et les propriétés géométriques et hydrauliques des principaux systèmes de drainage sont connus à l'échelle du temps géologique. Dans ce modèle, la migration secondaire est traitée comme un écoulement des hydrocarbures en phase séparée, contrôlé par la poussée d'Archimède, dans des aquifères hydrostatiques. La migration latérale est considérée comme un écoulement de type Boussinesq, à surface libre, avec des termes sources et puits représentant les apports venant des roches mères et les fuites à travers les couvertures et les failles. Ceci permet une description mathématique bidimensionnelle cartographiable d'un système de migration secondaire tridimensionnel et dépendant du temps. On utilise une approximation type différences finies à neuf points pour minimiser

Post-test analysis for the APR1400 LBLOCA DVI performance test using MARS

International Nuclear Information System (INIS)

Bae, Kyoo Hwan; Lee, Y. J.; Kim, H. C.; Bae, Y. Y.; Park, J. K.; Lee, W.

2002-03-01

Post-test analyses using a multi-dimensional best-estimate analysis code, MARS, are performed for the APR1400 LBLOCA DVI (Direct Vessel Injection) performance tests. This report describes the code evaluation results for the test data of various void height tests and direct bypass tests that have been performed at MIDAS test facility. MIDAS is a scaled test facility of APR1400 with the objective of identifying multi-dimensional thermal-hydraulic phenomena in the downcomer during the reflood conditions of a large break LOCA. A modified linear scale ratio was applied in its construction and test conditions. The major thermal-hydraulic parameters such as ECC bypass fraction, steam condensation fraction, and temperature distributions in downcomer are compared and evaluated. The evaluation results of MARS code for the various test cases show that: (a) MARS code has an advanced modeling capability of well predicting major multi-dimensional thermal-hydraulic phenomena occurring in the downcomer, (b) MARS code under-predicts the steam condensation rates, which in turn causes to over-predict the ECC bypass rates. However, the trend of decrease in steam condensation rate and increase in ECC bypass rate in accordance with the increase in steam flow rate, and the calculation results of the ECC bypass rates under the EM analysis conditions generally agree with the test data

Benjamin Crémieux, Inquiétude et reconstruction. Essai sur la littérature d’après-guerre

OpenAIRE

Brangé, Mireille

2016-01-01

Après xxe siècle (1924) en 2010 reparaît ce recueil de 1931 où l’A. étudie ensemble «les faits littéraires, les concordances et les divergences qui caractérisent une époque, les formes spécifiques qu’y prennent les œuvres, […] leurs rapports avec le milieu historique et social, la vision de la vie qui s’y exprime» (p. 8). La même année que les Essais critiques d’Arland et que les articles de Drieu La Rochelle sur «la fin de l’après-guerre», il interroge l’inquiétude des années 1920 et envisag...

Migration d'une broche dans le canal médullaire cervical après une ...

African Journals Online (AJOL)

Migration d'une broche dans le canal médullaire cervical après une ostéosynthèse de l'articulation acromio-claviculaire. Bah Aliou, El Alaoui Adil. Abstract. We report the case of a 49 year-old right-handed chef with left shoulder trauma occurred during a football game. The diagnosis was fracture of the distal quarter of ...

L’Allemagne : un non – lieu pour les exiles judéo-allemands après 1945 ?

OpenAIRE

Bohnekamp, Dorothea

2017-01-01

L’omniprésence de l’Allemagne dans les productions littéraires des exilés judéo-allemands en France après 1945 pose tout d’abord la question des différentes représentations de ce pays chez les rescapés. Le nombre important de métaphores spatiales interroge plus particulièrement le rôle de l’espace, matériel/urbain ou symbolique, dans la mémoire des émigrants et dans la reconstruction d’une Heimat souvent imaginaire. Après la guerre, cet attachement souvent ambivalent à l’Allemagne comme patri...

Analysis of MSGTR events for APR1400 by means of best estimate thermal-hydraulic system code

International Nuclear Information System (INIS)

Jeong, Ji Hwan; Kim, Sang Jae; Chang, Keun Sun; Lee, Jae Hun

2001-01-01

A multiple steam generator tube rupture (MSGTR) event has never occurred in the history of commercial nuclear reactor operation while single steam generator tube rupture (SGTR) event is reported to occur every two years. As there is no history of MSGTR event, the understandings of transients and consequences of this event are not so much. In this study, a postulated MSGTR event in advanced power reactor 1400 (APR1400) is analyzed using thermal-hydraulic system code. The APR 1400 is a two-loop, 1000 MWe, PWR supposed to be built in 2009. MARS1.4 is used in this study. The present study aims to understand the effects of rupture location in heat transfer tubes and selection of affected steam generator following a MSGTR event. The effects of five tube rupture locations are compared with each other. The comparison shows that the response of APR1400 is to allow shortest time for operator action following a tubes rupture in the vicinity of hot-leg side tube sheet and to allow longest time following a tube ruptures at the tube top. The MSSV lift time for rupture at tube-top is evaluated as 24.5% larger than that for rupture at hot-leg side tube sheet. Also, the MSSV lift time for four cases are compared in order to examine how long operator response time is allowed depending on which steam generator is affected. The comparison shows that the cases for both of two steam generators are affected allow longer time for operator action compared with the cases that a single steam generator is affected. Further more, the tube ruptures in the steam generator where a pressurizer is linked leads to the shortest operator response time

Real-Time PCR Quantification and Diversity Analysis of the Functional Genes aprA and dsrA of Sulfate-Reducing Prokaryotes in Marine Sediments of the Peru Continental Margin and the Black Sea.

Science.gov (United States)

Blazejak, Anna; Schippers, Axel

2011-01-01

Sulfate-reducing prokaryotes (SRP) are ubiquitous and quantitatively important members in many ecosystems, especially in marine sediments. However their abundance and diversity in subsurface marine sediments is poorly understood. In this study, the abundance and diversity of the functional genes for the enzymes adenosine 5'-phosphosulfate reductase (aprA) and dissimilatory sulfite reductase (dsrA) of SRP in marine sediments of the Peru continental margin and the Black Sea were analyzed, including samples from the deep biosphere (ODP site 1227). For aprA quantification a Q-PCR assay was designed and evaluated. Depth profiles of the aprA and dsrA copy numbers were almost equal for all sites. Gene copy numbers decreased concomitantly with depth from around 10(8)/g sediment close to the sediment surface to less than 10(5)/g sediment at 5 mbsf. The 16S rRNA gene copy numbers of total bacteria were much higher than those of the functional genes at all sediment depths and used to calculate the proportion of SRP to the total Bacteria. The aprA and dsrA copy numbers comprised in average 0.5-1% of the 16S rRNA gene copy numbers of total bacteria in the sediments up to a depth of ca. 40 mbsf. In the zone without detectable sulfate in the pore water from about 40-121 mbsf (Peru margin ODP site 1227), only dsrA (but not aprA) was detected with copy numbers of less than 10(4)/g sediment, comprising ca. 14% of the 16S rRNA gene copy numbers of total bacteria. In this zone, sulfate might be provided for SRP by anaerobic sulfide oxidation. Clone libraries of aprA showed that all isolated sequences originate from SRP showing a close relationship to aprA of characterized species or form a new cluster with only distant relation to aprA of isolated SRP. For dsrA a high diversity was detected, even up to 121 m sediment depth in the deep biosphere.

Soutenir le cheminement de stage d’apprentis enseignants au secondaire par un environnement d’apprentissage hybride / Supporting the advancement of student-teachers in their practica with the use of a hybrid learning environment

Directory of Open Access Journals (Sweden)

Stéphane Allaire

2009-03-01

Full Text Available Résumé : Dans un contexte de pratiques éducatives en renouvellement, la recherche participative étudie l’apport d’un environnement d’apprentissage hybride pour l’analyse réflexive de stagiaires en enseignement secondaire. Des analyses qualitatives et quantitatives descriptives illustrent le potentiel des dispositifs mis en place pour soutenir l’intégration à un contexte de stage innovateur, une réflexivité diversifiée et la coélaboration de connaissances. Abstract : In the context of evolving educational practices, participatory research is used to study the contribution of a hybrid learning environment when used by student teachers in secondary teaching for reflective analysis. Both quantitative analysis and qualitative descriptives illustrate the potential of the devices and strategies used to support the student teachers in their integration into an innovative practicum context, a diversified reflective practice and knowledge building.

The Experience of Staging Nijinsky's "L'Apres-Midi d'un Faune" in a Higher Education Dance Program

Science.gov (United States)

Curran, Tina

2010-01-01

This study documented the experiences of staging Vaslav Nijinsky's "L'Apres-midi d'un Faune" in a higher education dance program. The ballet was staged from Labanotation. Research questions focused on teaching and learning pedagogy, characterization of the process over time, experiences of the participants and teaching approaches. The project…

Verification of SAMG entry condition for APR1400

Energy Technology Data Exchange (ETDEWEB)

Yun, Junghyun; Kim, Taewan; Kim, Jonghyun [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2013-10-15

In the wake of the Fukushima accident, severe accident management has become important more than ever. While Emergency Operating Procedures (EOPs) focuses on cooling down the core during a design basis accident, the prime objective of severe accident management guideline (SAMG) is to prevent the release of radioactive material into the environment during a severe accident. Only one fixed value of core exit temperature (CET) has been applied for several decades to different types of nuclear power plants (NPPs) in Korea. Although the different types of NPPs have different cladding materials and system designs, the identical CET, i. e., 650 .deg. C, is applied as the entry condition to the SAMG of all the NPPs (except CANDU plants), i. e., Westinghouse type, OPR1000, and APR1400. In this paper, the transition point is re-evaluated for dominant severe accident sequences; station black-out (SBO), small break loss of coolant accident (SBLOCA), and me dium break loss of coolant accident (MBLOCA). In cases of SBO and SBLOCA, the current SAMG entry condition seems proper, while it needs to be reconsidered for MBLOCA case.

Analysis Of Feedwater Line Break Of APR1400 By MARS Code

International Nuclear Information System (INIS)

Nguyen Thi Thanh Thuy; Le Dai Dien, Hoang Minh Giang

2011-01-01

This paper will deal with analysis of Feed water Line Break problem (FWLB) of the APR 1400 NPP with initial conditions: operation at 100% of power, double-ended break area of 0.058 m 2 and the break location of the feedwater line between the check valve and the steam generator. The analysis was simulated by MARS code through two step: calculation for steady state and calculation for transient state with initial condition mentioned. Some output result were presented with explanation: sequence of events corresponding to the time of the accident, the system behavior as temperature, pressure, steam generator water levels as well as DNBR, etc. before and after the accident. (author)

Analysis Of Control Rod Ejection Of APR1400 By RELAP5

International Nuclear Information System (INIS)

Le Thi Thu; Hoang Minh Giang; Vo Thi Huong; Le Dai Dien

2011-01-01

This paper presents the analysis of Reactivity Induced Accident caused by ejection of a Control Element Assembly (CEA) from APR 1400 reactor vessel within 0.05 second. The initial condition were assumed as following: power level at 102%, delayed neutron fraction β = 412 pcm and CEA worth = 110 pcm. The analysis was simulated by RELAP5 code through two step: calculation of steady state and calculation of transient with initial condition mentioned as above. Some output results were presented with explanation: sequence of events corresponding to the time of the accident, the system behavior as power, reactivity feedback from fuel temperature changes (Doppler) as well as temperature, pressure, DNBR within 6 second of the accident. (author)

Case report

African Journals Online (AJOL)

cqq1a

5 sept. 2010 ... Abstract. Les tumeurs neuro-ectodermiques primitives ou sarcome d'Ewing sont classiquement des néoplasmes se développant aux dépends des tissus mous et des os. Les tumeurs neuro-ectodermiques primitives gastriques (pPNETs) sont extrêmement rares. Nous nous proposons, à travers le cas d'un.

Unit Risk Quotient (RQ) and Relative Significance of Radionuclide on Flora and Fauna to the EU-APR Optimization

Energy Technology Data Exchange (ETDEWEB)

Lee, Keunsung [KHNP-CRI, Daejeon (Korea, Republic of); Kim, Sukhoon [FNC Technology Co., Ltd., Yongin (Korea, Republic of); Lee, Chonghui [KEPCO E and C, Yongin (Korea, Republic of)

2015-05-15

As part of the project for acquiring the certification from EUR organization, in accordance with Articles 4.8 and 5.5 specified in Section 2.20 of EUR Volume 2, the effects of ionizing radiation from the standard design of EU-APR on biota and ecosystems during operation and decommissioning phases shall be assessed. This assessment must be carried out according to the ERICA (i.e. Environmental Risk from Ionizing Contaminants: Assessment and management) integrated approach. This paper describes the evaluation results for unit risk quotient and relative significance by radionuclide derived from performing Tier 1 assessment on flora and fauna for the EU-APR design using ERICA Tool. As specified previously, Pa-231 and Th-228 are the most significant for the terrestrial and for the marine/freshwater ecosystems, respectively. And, in terms of environmental risk, those radionuclides having the most impact on flora and fauna are relatively more significant than isotope having the least impact by about 7 to 10 orders of magnitude.

Unit Risk Quotient (RQ) and Relative Significance of Radionuclide on Flora and Fauna to the EU-APR Optimization

International Nuclear Information System (INIS)

Lee, Keunsung; Kim, Sukhoon; Lee, Chonghui

2015-01-01

As part of the project for acquiring the certification from EUR organization, in accordance with Articles 4.8 and 5.5 specified in Section 2.20 of EUR Volume 2, the effects of ionizing radiation from the standard design of EU-APR on biota and ecosystems during operation and decommissioning phases shall be assessed. This assessment must be carried out according to the ERICA (i.e. Environmental Risk from Ionizing Contaminants: Assessment and management) integrated approach. This paper describes the evaluation results for unit risk quotient and relative significance by radionuclide derived from performing Tier 1 assessment on flora and fauna for the EU-APR design using ERICA Tool. As specified previously, Pa-231 and Th-228 are the most significant for the terrestrial and for the marine/freshwater ecosystems, respectively. And, in terms of environmental risk, those radionuclides having the most impact on flora and fauna are relatively more significant than isotope having the least impact by about 7 to 10 orders of magnitude

CFD Analysis of Random Turbulent Flow Load in Steam Generator of APR1400 Under Normal Operation Condition

International Nuclear Information System (INIS)

Lim, Sang Gyu; You, Sung Chang; Kim, Han Gon

2011-01-01

Regulatory guide 1.20 revision 3 of the Nuclear Regulatory Committee (NRC) modifies guidance for vibration assessments of reactor internals and steam generator internals. The new guidance requires applicants to provide a preliminary analysis and evaluation of the design and performance of a facility, including the safety margins of during normal operation and transient conditions anticipated during the life of the facility. Especially, revision 3 require rigorous assessments of adverse flow effects in the steam dryer cased by flow-excited acoustic and structural resonances such as the abnormality from power-uprated BWR cases. For two nearly identical nuclear power plants, the steam system of one BWR plant experienced failure of steam dryers and the main steam system components when steam flow was increased by 16 percent for extended power uprate (EPU). The mechanisms of those failures have revealed that a small adverse flow changing from the prototype condition induced severe flow-excited acoustic and structural resonances, leading to structural failures. In accordance with the historical background, therefore, potential adverse flow effects should be evaluated rigorously for steam generator internals in both BWR and Pressurized Water Reactor (PWR). The Advanced Power Reactor 1400 (APR1400), an evolutionary light water reactor, increased the power by 7.7 percent from the design of the 'Valid Prototype', System80+. Thus, reliable evaluations of potential adverse flow effects on the steam generator of APR1400 are necessary according to the regulatory guide. This paper is part of the computational fluid dynamics (CFD) analysis results for evaluation of the adverse flow effect for the steam generator internals of APR1400, including a series of sensitivity analyses to enhance the reliability of CFD analysis and an estimation the effect of flow loads on the internals of the steam generator under normal operation conditions

Leomyosarcome du larynx | Abid | Journal Tunisien d'ORL et de ...

African Journals Online (AJOL)

Le leiomyosarcome laryngé est une tumeur musculaire lisse maligne rare. Il représente moins de 1% de toutes les tumeurs malignes laryngées. Nous rapportons un nouveau cas chez un patient de 63 ans. Le traitement a consisté en une laryngectomie totale avec curage ganglionnaire suivie de radiothérapie. A travers ce ...

angiomyxome agressif de la joue

African Journals Online (AJOL)

Les aspects cliniques, histologiques et thérapeutiques de la tumeur ont été discutés. Mots-clés : L'angiomyxome agressif, tumeur mésenchymateuse, exérèse, récidive. SUMMARY. An aggressive angiomyxoma is a mesenchymal tumour arising from connective tissues with a predilection for the fema- le pelvic soft parts.

Case series

African Journals Online (AJOL)

abp

10 déc. 2015 ... Le diagnostic de ces tumeurs est difficile, nécessitant une approche multidisciplinaire, à savoir oto-rhino- laryngologique, radiologique et anatomopathologique. Notre étude rétrospective concerne 32 cas de tumeurs malignes naso-sinusiennes, colligées au service d'ORL de l'hôpital militaire Avicenne de ...

Rhabdomyosarcome geant de la cuisse chez l'adulte jeune : a ...

African Journals Online (AJOL)

Le rhabdomyosarcome est une tumeur maligne rare de l'enfant développée à partir du muscle squelettique. ... les tumeurs au Togo est le retard de consultation des patients, l'accessibilité des moyens d'investigation et le plateau technique souvent limité, ce qui rend difficile la prise en charge adéquate de ces pathologies.

Preliminary design of S-CO{sub 2} Brayton cycle for APR-1400 with power generation and desalination process

Energy Technology Data Exchange (ETDEWEB)

Bae, Seong Jun; Lee, Won Woong; Jeong, Yong Hoon; Lee, Jeong Ik [KAIST, Daejeon (Korea, Republic of); Yoon, Ho Joon [KUSTAR, Abu Dhabi (United Arab Emirates)

2015-10-15

This study was conducted to explore the capabilities of the S-CO{sub 2} Brayton cycle for a cogeneration system for APR-1400 application. Three concepts of the S-CO{sub 2} simple recuperated co-generation cycle were designed. A supercritical CO{sub 2} (S-CO{sub 2}) Brayton cycle is recently receiving significant attention as a promising power conversion system in wide range of energy applications due to its high efficiency and compact footprint. The main reason why the S-CO{sub 2} Brayton cycle has these advantages is that the compressor operates near the critical point of CO{sub 2} (30.98 .deg. C, 7.38MPa) to reduce the compression work significantly compared to the other Brayton cycles. In this study, the concept of replacing the entire steam cycle of APR-1400 with the S-CO{sub 2} Brayton cycle is evaluated. The power generation purpose S-CO{sub 2} Brayton cycles are redesigned to generate power and provide heat to the desalination system at the same time. The performance of these newly suggested cycles are evaluated in this paper. The target was to deliver 147MW heat to the desalination process. The thermal efficiencies of the three concepts are not significantly different, but the 3{sup rd} concept is relatively simpler than other cycles because only an additional heat exchanger is required. Although the 2{sup nd} concept is relatively complicated in comparison to other concepts, the temperatures at the inlet and outlet of the DHX are higher than that of the others. As shown in the results, the S-CO{sub 2} Brayton cycles are not easy to outperform the steam cycle with very simple layout and general design points under APR-1400 operating condition. However, this study shows that the S-CO{sub 2} Brayton cycles can be designed as a co-generation cycle while producing the target desalination heat with a simple configuration. In addition, it was also found that the S-CO{sub 2} Brayton cycle can achieve higher cycle thermal efficiency than the steam power cycle under

Best-estimated multi-dimensional calculation during LB LOCA for APR1400

International Nuclear Information System (INIS)

Oh, D. Y.; Bang, Y. S.; Cheong, A. J.; Woong, S.; Korea, W.

2010-01-01

Best-estimated (BE) calculation with uncertainty quantification for the emergency core cooling system (ECCS) performance analysis during Loss of Coolant Accident (LOCA) is more broadly used in nuclear industries and regulations. In Korea, demand on regulatory audit calculation is continuously increasing to support the safety review for life extension, power up-rating and advanced nuclear reactor design. The thermal-hydraulic system code, MARS (Multi-dimensional Analysis of Reactor Safety), with multi-dimensional capability is used for audit calculation. It achieves to describe the complicated phenomena in reactor coolant system by very effectively consolidating the one dimensional RELAP5/MOD3 with the multidimensional COBRA-TF codes. The advanced power reactors (APR1400) to be evaluated has four separated hydraulic trains of the high pressure injection system (HPSI) with direct vessel injection (DVI) which is different from the existing commercial PWRs. Also, the therma-hydraulic behavior of DVI plant would be considerably different from that of a cold-leg safety injection since the low pressure safety injection system are eliminated and the high pressure safety flow are injected into the specific elevation of reactor vessel downcomer. The ECCS bypass induced by the downcomer boiling due to hot wall heating of reactor vessel during reflooding phase is one of the important phenomena which should be considered in DVI plants. Therefore, in this study, BE calculation with one-dimensional (1-D) and multi-dimensional (multi-D) MARS models during LBLOCA are performed for APR1400 plant. In the multi-D evaluation, the reactor vessel is modeled by multi-D components and the specific treatment of flow path inside reactor vessel, e.g., upper guide structure, is essential. The concept of hot zone is adopted to simulate the limiting thermal-hydraulic conditions surrounding hot rod, which is similar to hot channel in 1-D. Also, alternative treatment of the hot rods in multi-D is

Recovery and radio-resistance in mice after external irradiation; Restauration et radio-resistance chez la souris apres irradiation externe

Energy Technology Data Exchange (ETDEWEB)

Le Guillou, S [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1965-07-01

The author presents a literature study concerning recovery from external irradiation and an analysis of experimental data (which appear to suggest the idea of a radio-resistance in animals), as well as the hypotheses put forward for explaining this phenomenon. The author then describes an experiment carried out on mice whose LD 50/30 days increased from 1005 to 1380 rads and for which it was shown that an increase occurs in the number of certain anti-bodies circulating after a low dose of {gamma} irradiation. (author) [French] L'auteur presente une etude bibliographique de la restauration apres irradiation externe et une analyse des donnees experimentales qui paraissent suggerer la notion de radioresistance chez les animaux ainsi que les hypotheses cherchant a expliquer ce phenomene. Il relate ensuite une experience realisee sur des souris dont la DL 50/30 jours est passee de 1005 a 1380 rads et dans laquelle est montree l'augmentation de certains anticorps circulant apres une faible dose d'irradiation gamma. (auteur)

Le mélanome malin de la fosse nasale

Science.gov (United States)

Rekik, Wafa; Goucha, Aida; Hamdane, Mohamed Moncef; Debbabi, Boutheina; EL May, Ahmed; Gammoudi, Amor

2012-01-01

Le mélanome muqueux primitif de la fosse nasale est une tumeur maligne très agressive, rare, constituant 1% de l’ensemble des mélanomes. Sa symptomatologie est non spécifique et son diagnostic est anatomo-pathologique, appuyé par l’immunohistochimie. Son traitement est essentiellement chirurgical basé sur une résection large de la tumeur. Le pronostic est défavorable, caractérisé par des récidives et des métastases fréquentes et un taux de survie bas. Nous rapportons dans ce travail un nouveau cas de mélanome malin primitif de la fosse nasale, tout en précisant les caractéristiques de cette tumeur. PMID:23024827

A combination of p53-activating APR-246 and phosphatidylserine-targeting antibody potently inhibits tumor development in hormone-dependent mutant p53-expressing breast cancer xenografts

Directory of Open Access Journals (Sweden)

Liang Y

2018-03-01

Full Text Available Yayun Liang,1 Benford Mafuvadze,1 Cynthia Besch-Williford,2 Salman M Hyder1 1Deparment of Biomedical Sciences and Dalton Cardiovascular Research Center, Columbia, MO, USA; 2IDEXX BioResearch, Columbia, MO, USA Background: Between 30 and 40% of human breast cancers express a defective tumor suppressor p53 gene. Wild-type p53 tumor suppressor protein promotes cell-cycle arrest and apoptosis and inhibits vascular endothelial growth factor–dependent angiogenesis, whereas mutant p53 protein (mtp53 lacks these functions, resulting in tumor cell survival and metastasis. Restoration of p53 function is therefore a promising drug-targeted strategy for combating mtp53-expressing breast cancer. Methods: In this study, we sought to determine whether administration of APR-246, a small-molecule drug that restores p53 function, in combination with 2aG4, an antibody that targets phosphatidylserine residues on tumor blood vessels and disrupts tumor vasculature, effectively inhibits advanced hormone-dependent breast cancer tumor growth. Results: APR-246 reduced cell viability in mtp53-expressing BT-474 and T47-D human breast cancer cells in vitro, and significantly induced apoptosis in a dose-dependent manner. However, APR-246 did not reduce cell viability in MCF-7 breast cancer cells, which express wild-type p53. We next examined APR-246’s anti-tumor effects in vivo using BT-474 and T47-D tumor xenografts established in female nude mice. Tumor-bearing mice were treated with APR-246 and/or 2aG4 and tumor volume followed over time. Tumor growth was more effectively suppressed by combination treatment than by either agent alone, and combination therapy completely eradicated some tumors. Immunohistochemistry analysis of tumor tissue sections demonstrated that combination therapy more effectively induced apoptosis and reduced cell proliferation in tumor xenografts than either agent alone. Importantly, combination therapy dramatically reduced the density of blood

Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d'etude des Tumeurs Endocrines (GTE) cohort study.

Science.gov (United States)

Thevenon, Julien; Bourredjem, Abderrahmane; Faivre, Laurence; Cardot-Bauters, Catherine; Calender, Alain; Murat, Arnaud; Giraud, Sophie; Niccoli, Patricia; Odou, Marie-Françoise; Borson-Chazot, Françoise; Barlier, Anne; Lombard-Bohas, Catherine; Clauser, Eric; Tabarin, Antoine; Parfait, Béatrice; Chabre, Olivier; Castermans, Emilie; Beckers, Albert; Ruszniewski, Philippe; Le Bras, Morgane; Delemer, Brigitte; Bouchard, Philippe; Guilhem, Isabelle; Rohmer, Vincent; Goichot, Bernard; Caron, Philippe; Baudin, Eric; Chanson, Philippe; Groussin, Lionel; Du Boullay, Hélène; Weryha, Georges; Lecomte, Pierre; Penfornis, Alfred; Bihan, Hélène; Archambeaud, Françoise; Kerlan, Véronique; Duron, Françoise; Kuhn, Jean-Marc; Vergès, Bruno; Rodier, Michel; Renard, Michel; Sadoul, Jean-Louis; Binquet, Christine; Goudet, Pierre

2013-05-15

Multiple endocrine neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors. Although genotype-phenotype studies have so far failed to identify any statistical correlations, some families harbor recurrent tumor patterns. The function of MENIN is unclear, but has been described through the discovery of its interacting partners. Mutations in the interacting domains of MENIN functional partners have been shown to directly alter its regulation abilities. We report on a cohort of MEN1 patients from the Groupe d'étude des Tumeurs Endocrines. Patients with a molecular diagnosis and a clinical follow-up, totaling 262 families and 806 patients, were included. Associations between mutation type, location or interacting factors of the MENIN protein and death as well as the occurrence of MEN1-related tumors were tested using a frailty Cox model to adjust for potential heterogeneity across families. Accounting for the heterogeneity across families, the overall risk of death was significantly higher when mutations affected the JunD interacting domain (adjusted HR = 1.88: 95%-CI = 1.15-3.07). Patients had a higher risk of death from cancers of the MEN1 spectrum (HR = 2.34; 95%-CI = 1.23-4.43). This genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor and should thus be considered for surgical indications, genetic counseling and follow-up.

Comparison of APR1400 safety between brake site and shin-Kori site Due to the difference in the climate conditions

International Nuclear Information System (INIS)

Yoon, Ho Joon; Lee, Jeong Ik; Lee, Jeong Ik

2012-01-01

Brake Nuclear Power Plant (BNPP) is now under the construction based on APR1400 designed by Korean Electric Power Corporation (KEPCO). APR1400 is a two loop pressurized water reactor, the nuclear steam supply system (NSSS) US designed for about put of 4,000 MWt, with a corresponding electrical output of approximately 1,390 MWe. The first APR1400 (SKN 3 and 4) constructed in Shin-Kori, Korea has been modified according to the surrounding environment of the United Arab Emirates. In this paper, authors would like to compare safety issues between B NPP and Skin due to the changes of surroundings, since the site characteristics are very different. For instance, the mean annual air temperature in the UAE is 28 .deg. C and the peak air temperature was recorded as 48.8 .deg. C. Sea temperatures are varying from 17. deg. C in January to 35. deg. C in August, while that of Korea is in 9-16. deg. C range. Hot climate of UAE and the malfunction of HVAC system can lead the increasing of the water temperature in safety injection system (SIS). The heated water in SIS may affect the safety margin of the peak cladding temperature (PCT). The change of PCT and response time according to design basis accident scenarios such as large break LOCA are analyzed in detail. To evaluate such effect, Mars code was utilized to evaluate assumed condition by KAIST and the analyses of the results were carried out by Khalifa Univ.

Réduction des pertes de mangues après la récolte en Asie du Sud ...

International Development Research Centre (IDRC) Digital Library (Canada)

29 avr. 2016 ... Près de 70 % de la production mondiale de mangues provient de l'Inde, mais les pertes après récolte en raison d'une manutention, d'un transport et d'une transformation inadéquats peuvent atteindre 35 %. De plus, les prix obtenus par les producteurs sont souvent peu élevés à cause de la saturation du ...

Le don après un décès d'origine cardiocirculatoire au Canada

Science.gov (United States)

Shemie, Sam D.; Baker, Andrew J.; Knoll, Greg; Wall, William; Rocker, Graeme; Howes, Daniel; Davidson, Janet; Pagliarello, Joe; Chambers-Evans, Jane; Cockfield, Sandra; Farrell, Catherine; Glannon, Walter; Gourlay, William; Grant, David; Langevin, Stéphan; Wheelock, Brian; Young, Kimberly; Dossetor, John

2006-01-01

Résumé Ces recommandations sont le fruit d'un processus multidisciplinaire national ayant duré un an et visant à déterminer si et comment l'on pourrait procéder au don d'organes après un décès d'origine cardiocirculatoire («don après le décès cardiocirculatoire», ou DDC) au Canada. Le forum national organisé en février 2005 a permis aux participants de discuter et d'élaborer des recommandations sur les principes, interventions et pratiques se rapportant au DDC. Les aspects éthiques et juridiques ont été abordés dans les discussions. À la fin du Forum, la majorité des participants ont été favorables à l'implantation de programmes de DDC au Canada. Les participants du Forum ont également convenu qu'il fallait formuler et prôner des valeurs fondamentales pour orienter l'élaboration de programmes et de protocoles basés sur le cadre médical, éthique et juridique établi lors de cette réunion. Même si la possibilité d'un don d'organes et de tissus doit faire partie intégrante des soins de fin de vie, il faut insister sur le fait que le devoir de diligence envers les patients mourants et leurs familles doit demeurer la priorité des équipes soignantes. La complexité et les répercussions profondes du décès sont reconnues et doivent être respectées, de même que les différences personnelles, ethnoculturelles et religieuses face à la mort et au don d'organes. Les décisions d'arrêter le traitement de maintien des fonctions vitales, la prise en charge des derniers moments de la vie et le diagnostic de décès selon des critères cardiocirculatoires doivent être distincts et indépendants des processus de don et transplantation. Ce rapport contient des recommandations destinées aux gestionnaires de program, aux autorités sanitaires régionales et aux instances appelés à élaborer les protocoles de DDC. Les programmes doivent être conçus en fonction des éléments suivants : direction et planification locales, éducation et

Hemangiopericytome Meninge: Rapport clinico-pathologique d\\'un cas

African Journals Online (AJOL)

Nous rapportons l\\'observation d\\'un hémangiopéricytome de localisation méningée (HPCM) chez une femme de 42 ans reçue à l\\'Hôpital Général de Yaoundé, Cameroun. Cette tumeur est rare chez nous, et la localisation méningée exceptionnelle. Le diagnostic histologique est difficile, la tumeur étant souvent confondue ...

Case series

African Journals Online (AJOL)

ebutamanya

16 mars 2016 ... Le but de ce travail est d'étudier les facteurs prédictifs de malignité dans les tumeurs parotidiennes à travers une étude rétrospective sur 76 cas de tumeurs de la parotide traités au service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale de l'hôpital militaire Avicenne de Marrakech entre janvier.

Transformation des découvertes en génomique pour soigner les ...

International Development Research Centre (IDRC) Digital Library (Canada)

Transformation des découvertes en génomique pour soigner les tumeurs cérébrales ultrahypermutantes déficientes en système de réparation des mésappariements. Les tumeurs malignes au cerveau sont la cause la plus courante de décès chez les enfants atteints du cancer, mais il n'y a pas de traitement connu.

Preliminary Analysis of Ex-Vessel Steam Explosion using TEXAS-V code for APR1400

International Nuclear Information System (INIS)

Song, Sung Chu; Lee, Jung Jae; Cho, Yong Jin; Hwang, Taesuk

2013-01-01

The purpose of this study is to explore input development and the audit calculation using TEXAS-V code for ex-vessel steam explosion for a flooded reactor cavity of APR1400. TEXAS computational models are one of the simplified tools for simulations of fuel-coolant interaction during mixing, triggering and explosion phase. The models of TEXAS code were validated by performing the fundamental experimental investigation in the KROTOS facility at JRC, Ispra. The experiments such as KROTOS and FARO experiment are aimed at providing benchmark data to examine the effect of fuel-coolant initial conditions and mixing on explosion energetics with alumina and prototypical core material. TEXAS-V code used in this study was to analyze and predict the ex-vessel steam explosion for a reactor scale. The input deck to simulate the flooded reactor cavity of APR1400 is developed and base case calculation is performed. This study will provide a base for further study. The code will be of use for the evaluation and sensitivity study of ex-vessel steam explosion for ERVC strategy in the future studies. Analysis result of this study is similar to the result of other study. Through this study, it is found that TEXAS-V could be the used as a tool for predicting the steam explosion load on a reactor scale, as fast running computer code. In addition, TEXAS-V code could be to evaluate the impact of various uncertainties, which are not clearly understood yet, to provide a conservative envelope for the steam explosion

Preliminary Analysis of Ex-Vessel Steam Explosion using TEXAS-V code for APR1400

Energy Technology Data Exchange (ETDEWEB)

Song, Sung Chu; Lee, Jung Jae; Cho, Yong Jin; Hwang, Taesuk [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2013-10-15

The purpose of this study is to explore input development and the audit calculation using TEXAS-V code for ex-vessel steam explosion for a flooded reactor cavity of APR1400. TEXAS computational models are one of the simplified tools for simulations of fuel-coolant interaction during mixing, triggering and explosion phase. The models of TEXAS code were validated by performing the fundamental experimental investigation in the KROTOS facility at JRC, Ispra. The experiments such as KROTOS and FARO experiment are aimed at providing benchmark data to examine the effect of fuel-coolant initial conditions and mixing on explosion energetics with alumina and prototypical core material. TEXAS-V code used in this study was to analyze and predict the ex-vessel steam explosion for a reactor scale. The input deck to simulate the flooded reactor cavity of APR1400 is developed and base case calculation is performed. This study will provide a base for further study. The code will be of use for the evaluation and sensitivity study of ex-vessel steam explosion for ERVC strategy in the future studies. Analysis result of this study is similar to the result of other study. Through this study, it is found that TEXAS-V could be the used as a tool for predicting the steam explosion load on a reactor scale, as fast running computer code. In addition, TEXAS-V code could be to evaluate the impact of various uncertainties, which are not clearly understood yet, to provide a conservative envelope for the steam explosion.

Reliability analysis of protection system of advanced pressurized water reactor - APR 1400

International Nuclear Information System (INIS)

Varde, P. V.; Choi, J. G.; Lee, D. Y.; Han, J. B.

2003-04-01

Reliability analysis was carried out for the protection system of the Korean Advanced Pressurized Water Reactor - APR 1400. The main focus of this study was the reliability analysis of digital protection system, however, towards giving an integrated statement of complete protection reliability an attempt has been made to include the shutdown devices and other related aspects based on the information available to date. The sensitivity analysis has been carried out for the critical components / functions in the system. Other aspects like importance analysis and human error reliability for the critical human actions form part of this work. The framework provided by this study and the results obtained shows that this analysis has potential to be utilized as part of risk informed approach for future design / regulatory applications

Construire un jeu éducatif en ligne, Asthme : 1, 2, 3 … Respirez!, pour sensibiliser les jeunes du secondaire aux problèmes de l'asthme

Directory of Open Access Journals (Sweden)

Louise Sauvé

2011-05-01

Full Text Available Dans le cadre d’une étude financée par le Conseil de recherche en sciences sociales et humaines (CRSH, 2008-2011, nous examinons l’efficacité d’un jeu éducatif en ligne sur l’apprentissage cognitif (structuration des connaissances et affectif (changement d'attitudes. Construit à partir des règles du jeu de société Parchési auxquelles plusieurs adaptations ont été apportées, le jeu Asthme : 1, 2, 3… Respirez! a été conçu pour s'inscrire dans le programme d’éducation à la santé pour les élèves du secondaire IV et V, âgés entre 15 et 17 ans. Dans cet article, nous présenterons brièvement les problèmes associés à l’asthme au Québec et au Canada. Ensuite, nous expliciterons l'apport des jeux éducatifs sur la structuration des connaissances et le changement d’attitudes ainsi que les paramètres d'apprentissage utilisés pour construire le jeu. Enfin, nous décrirons comment le jeu a été construit et la mise à l'essai réalisée avec 40 élèves pour évaluer son design, sa lisibilité pédagogique et sa convivialité.

Analysis of a 12-Finger Rod Drop using RETRAN/MASTER Code System for APR1400

International Nuclear Information System (INIS)

Yu, Keuk Jong; You, Sung Chang; Kim, Han Gon

2009-01-01

The Optimized Power Reactor 1000 (OPR1000) has 4-finger and 12-finger Control Element Assemblies (CEAs). When the 12-finger CEA is dropped, Core Protection Calculator System (CPCS) shuts down the reactor to prevent fuel damage that could occur from the sudden reactor power peaking. By contrast, the improved CPCS of Advanced Power Reactor 1400 (APR1400), which has systems similar to those of the OPR1000, decreases reactor power rapidly using its Reactor Power Cutback System (RPCS) to avoid unwanted reactor trips caused by the CPCS during a 12- finger CEA drop event. RETRAN is a best-estimate code for transient analysis of Non-LOCA. The RETRAN control logic, which includes the function of reducing reactor power during a 12-Finger CEA drop, has been developed for the APR1400. A MATRAN program has also been developed. MATRAN is the interface program for realtime processing to connect RETRAN with MASTER code which is a nuclear analysis and design code. MATRAN supplies adequate feedback reactivities from the MASTER code to RETRAN code. The purpose of this study is to analyze the behavior of a nuclear reactor core and its primary system using conventional RETRAN analysis procedure and MATRAN program analysis procedure during a 12- finger CEA drop. In addition, the axial power distribution and Axial Shape Index (ASI) are produced by the MATRAN program and they are confirmed as within operation limits

Recovery and radio-resistance in mice after external irradiation; Restauration et radio-resistance chez la souris apres irradiation externe

Energy Technology Data Exchange (ETDEWEB)

Le Guillou, S. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1965-07-01

The author presents a literature study concerning recovery from external irradiation and an analysis of experimental data (which appear to suggest the idea of a radio-resistance in animals), as well as the hypotheses put forward for explaining this phenomenon. The author then describes an experiment carried out on mice whose LD 50/30 days increased from 1005 to 1380 rads and for which it was shown that an increase occurs in the number of certain anti-bodies circulating after a low dose of {gamma} irradiation. (author) [French] L'auteur presente une etude bibliographique de la restauration apres irradiation externe et une analyse des donnees experimentales qui paraissent suggerer la notion de radioresistance chez les animaux ainsi que les hypotheses cherchant a expliquer ce phenomene. Il relate ensuite une experience realisee sur des souris dont la DL 50/30 jours est passee de 1005 a 1380 rads et dans laquelle est montree l'augmentation de certains anticorps circulant apres une faible dose d'irradiation gamma. (auteur)

Un cas d'angiosarcome de l'oreille externe | Issara | Pan African ...

African Journals Online (AJOL)

L'angiosarcome de l'oreille est une tumeur maligne très rare, et localement très agressive. Elle représente 4-5% des sarcomes cutanés et moins de 1% de tous les sarcomes. Notre objectif est de décrire et de discuter les modalités diagnostiques et thérapeutiques de cette tumeur maligne. A travers le cas clinique d'une ...

Le ganglioneurome rétropéritonéal: À propos de 5 cas et revue de la ...

African Journals Online (AJOL)

Le ganglioneurome est une tumeur neurogène bénigne, rare, qui se développe à partir des cellules ganglionnaires sympathiques et qui se localise essentiellement dans la région rétropéritonéale. Nous rapportons cinq cas de ganglioneuromes rétropéritonéaux, ayant eu une exérèse complète de la tumeur avec évolution ...

The Analysis of Uncontrolled CEA Bank withdrawal from low power Accident for APR1400 Using KNAP

International Nuclear Information System (INIS)

Yang, Chang-Keun; Kim, Yo-Han; Ha, Sang-Jun

2006-01-01

In Korea, the nuclear industries such as fuel manufacturer, the architect engineer and the utility, have been using the methodologies and codes of vendors, such as Westinghouse(WH), Combustion Engineering(CE), for the safety analyses of nuclear power plants. Consequently the industries have kept up the many organizations to operate the methodologies and to maintain the codes for each vendor. It may cause difficulty to improve the safety analyses efficiency and technology related. So, the necessity another of methodologies and code systems applicable to Non- LOCA, beyond design basis accident and performance analyses for all types of pressurized water reactor (PWR) has been raised. As the first requirement, the best-estimate codes were required for applicable wider application area and realistic behavior prediction of power plants with various and sophisticated functions. After the review on several candidates, RETRAN-3D has been chosen as a system analysis code. The draft version of the methodology was developed based on the references for the general purpose, and modified to apply it to specific plants in Korea. As a part of the feasibility estimation for the methodology and code system, uncontrolled CEA bank withdrawal from low power accident for the Advanced Power Reactor 1400(APR1400) was selected to verify the feasibility using the RETRAN-3D. And the results were compared with the Standard Safety Analysis Reports (SSAR) of APR1400

Performance Assessment of Turbulence Models for the Prediction of the Reactor Internal Flow in the Scale-down APR+

International Nuclear Information System (INIS)

Lee, Gonghee; Bang, Youngseok; Woo, Swengwoong; Kim, Dohyeong; Kang, Minku

2013-01-01

The types of errors in CFD simulation can be divided into the two main categories: numerical errors and model errors. Turbulence model is one of the important sources for model errors. In this study, in order to assess the prediction performance of Reynolds-averaged Navier-Stokes (RANS)-based two equations turbulence models for the analysis of flow distribution inside a 1/5 scale-down APR+, the simulation was conducted with the commercial CFD software, ANSYS CFX V. 14. In this study, in order to assess the prediction performance of turbulence models for the analysis of flow distribution inside a 1/5 scale-down APR+, the simulation was conducted with the commercial CFD software, ANSYS CFX V. 14. Both standard k-ε model and SST model predicted the similar flow pattern inside reactor. Therefore it was concluded that the prediction performance of both turbulence models was nearly same. Complex thermal-hydraulic characteristics exist inside reactor because the reactor internals consist of fuel assembly, control rod assembly, and the internal structures. Either flow distribution test for the scale-down reactor model or computational fluid dynamics (CFD) simulation have been conducted to understand these complex thermal-hydraulic features inside reactor

Réduction des pertes de mangues après la récolte en Asie du Sud ...

International Development Research Centre (IDRC) Digital Library (Canada)

29 avr. 2016 ... On a également conçu des boîtes spéciales contenant de la fibre de banane imprégnée d'hexanal, dont l'utilisation pour le transport de la mangue permet de conserver le fruit beaucoup plus longtemps. Réduction des pertes de mangues après la récolte en Asie du Sud​ (PDF, 506 Ko). Il s'agit de l'une ...

Minimum containment pressure and its effect on ECCS performance of APR-1400

International Nuclear Information System (INIS)

Kim, In Goo; Bang, Young S.; Kim, Hho Jung

2004-01-01

The containment pressure has a strong effect on the late reheat behavior for a large break LOCA, associated with the DVI issue. The downcomer boiling, which occurs during the post-reflood phase, has a negative effect on core cooling for a LBLOCA. Because the downcomer boiling is enhanced as the containment pressure decreases, how to determine containment pressure is important to the evaluation of ECCS performance. In spite of its importance of containment pressure, there are few studies on the containment pressure and the interaction between RCS and containment thermal hydraulics. To have a better knowledge of the effect of containment pressure on APR-1400 ECCS performance, a parametric study for containment pressure has been carried out. Also, the interaction between RCS and containment behavior has been also investigated

Use case driven approach to develop simulation model for PCS of APR1400 simulator

International Nuclear Information System (INIS)

Dong Wook, Kim; Hong Soo, Kim; Hyeon Tae, Kang; Byung Hwan, Bae

2006-01-01

The full-scope simulator is being developed to evaluate specific design feature and to support the iterative design and validation in the Man-Machine Interface System (MMIS) design of Advanced Power Reactor (APR) 1400. The simulator consists of process model, control logic model, and MMI for the APR1400 as well as the Power Control System (PCS). In this paper, a use case driven approach is proposed to develop a simulation model for PCS. In this approach, a system is considered from the point of view of its users. User's view of the system is based on interactions with the system and the resultant responses. In use case driven approach, we initially consider the system as a black box and look at its interactions with the users. From these interactions, use cases of the system are identified. Then the system is modeled using these use cases as functions. Lower levels expand the functionalities of each of these use cases. Hence, starting from the topmost level view of the system, we proceeded down to the lowest level (the internal view of the system). The model of the system thus developed is use case driven. This paper will introduce the functionality of the PCS simulation model, including a requirement analysis based on use case and the validation result of development of PCS model. The PCS simulation model using use case will be first used during the full-scope simulator development for nuclear power plant and will be supplied to Shin-Kori 3 and 4 plant. The use case based simulation model development can be useful for the design and implementation of simulation models. (authors)

Multi-analytical characterisation of D’Aprés Cormon by José Veloso Salgado

Energy Technology Data Exchange (ETDEWEB)

Cardeira, A.M. [Faculdade de Belas-Artes da Universidade de Lisboa, Largo da Academia Nacional de Belas-Artes, 1249-058 Lisboa (Portugal); Centro de Física Atómica da Universidade de Lisboa, Av. Professor Gama Pinto 2, 1649-003 Lisboa (Portugal); Longelin, S. [Centro de Física Atómica da Universidade de Lisboa, Av. Professor Gama Pinto 2, 1649-003 Lisboa (Portugal); Costa, S.; Candeias, A. [Laboratório José de Figueiredo, Direcção Geral do Património Cultural, Rua das Janelas Verdes 37, 1249-018 Lisboa (Portugal); Laboratório HERCULES e Centro de Química de Évora, Universidade de Évora, Largo Marquês de Marialva 8, 7000 Évora (Portugal); Carvalho, M.L. [Centro de Física Atómica da Universidade de Lisboa, Av. Professor Gama Pinto 2, 1649-003 Lisboa (Portugal); Manso, M., E-mail: marta974@cii.fc.ul.pt [Centro de Física Atómica da Universidade de Lisboa, Av. Professor Gama Pinto 2, 1649-003 Lisboa (Portugal)

2014-07-15

This case study reveals the analytical characterisation carried out on ‘D’Aprés Cormon’ (1891) by Veloso Salgado, a copy of ‘Caïn’ (1880) by Fernando Cormon, belonging nowadays to Musée d’Orsay. Infrared Reflectography made in situ revealed underdrawing grid that was used to transpose the original painting to a smaller scale, pictorial style, execution method and retouched/restored areas. In situ EDXRF analysis together with Raman microscopy allowed the identification of gypsum, lead white, titanium white, yellow ochre, vermilion, ultramarine and lamp black. These results provide valuable information about the Salgado’s palette and his production technique.

Le ganglioneurome rétropéritonéal: À propos de 5 cas et revue de la ...

African Journals Online (AJOL)

N. Rebai

Résumé. Le ganglioneurome est une tumeur neurogène bénigne, rare, qui se développe à partir des cellules ganglion- naires sympathiques et qui se localise essentiellement dans la région rétropéritonéale. Nous rapportons cinq cas de ganglioneuromes rétropéritonéaux, ayant eu une exérèse complète de la tumeur avec ...

Appraisal of the Psychiatric Diagnostic Screening Questionnaire in a perinatal cohort: The APrON study.

Science.gov (United States)

Leung, Brenda; Letourneau, Nicole; Bright, Katherine; Giesbrecht, Gerald F; Ntanda, Henry; Gagnon, Lisa

2017-08-01

Depression and anxiety are routinely screened as part of perinatal care. However, other Axis 1 disorders and specific anxiety disorders are less likely to be screened or assessed as part of obstetric care. The objective of this study was to determine whether the Psychiatric Diagnostic Screening Questionnaire (PDSQ) is a potentially useful tool to screen for psychiatric conditions in pregnant and postpartum women in a community setting. We compared the prevalence of DSM Axis I disorders obtained on the PDSQ with: (1) the prevalence of these disorders reported in previous studies of pregnant and postpartum women, and (2) scores obtained on the Edinburgh Postpartum Depression Scale (EPDS) and the Symptom Checklist-90-Revised (SCL-90R) anxiety scale. Data were obtained from the Alberta Pregnancy Outcomes and Nutrition (APrON) study. The PDSQ was completed by 1575 women prenatally and 1481 postnatally. The three most prevalent PDSQ conditions were social phobia, somatic disorder, and obsessive-compulsive disorder (OCD). The prevalence of social phobia, alcohol disorder, OCD and psychosis were higher in the APrON cohort compared with statistics in the literature. The proportion of women meeting depression and anxiety cut-offs on the PDSQ were lower than for the EPDS and the SCL-90R. The Cohens Kappa index ( k) indicated poor to fair agreement between the measures in classifying pregnant women as depressed or anxious. The PDSQ subscales may not be appropriate for the pregnant population. Research into instruments more specific to pregnant and postpartum women are needed to determine the prevalence of psychiatric disorders in this population.

Precificação de consultoria empresarial com a contribuição das estratégias de apreçamento = Entrepreneurial Counseling Pricing with Pricing Strategy Contribution

OpenAIRE

Nivaldo João dos Santos; Erves Ducati; Antonio Cezar Bornia

2008-01-01

A precificação de serviços de consultoria também pode se beneficiar dos conceitos e idéias das estratégias de apreçamento de bens de consumo de massa, especificamente na área de consultoria de gestão empresarial. Apesar deste campo ser dominado por grandes corporações multinacionais, ainda existe espaço para empresas e profissionais nacionais. Por se tratar de mercado que envolve valores de grande magnitude, imaginasse que as instituições de sucesso adotem estratégia de apreçamento. Neste tra...

Contrôle hormonal des caractéristiques des fibres musculaires après la naissance

OpenAIRE

Cassar-Malek, Isabelle; Listrat, Anne; Picard, Brigitte

1998-01-01

Après la naissance, la croissance et les propriétés contractiles et métaboliques des fibres musculaires sont soumises à une régulation endocrinienne complexe. A l’exception des glucocorticoïdes, la plupart des hormones présente une action anabolique sur le tissu musculaire. Leur influence sur les caractéristiques des fibres est cependant très différente. Ainsi, les hormones somatotropes affectent peu la composition en fibres des muscles. La GH, comme l’IGF-1, régulerait cependant l’expression...

Case report

African Journals Online (AJOL)

ebutamanya

5 mai 2015 ... Abstract. Les tumeurs bénignes du muscle lisse sont fréquentes dans le tractus gastro-intestinal et génito-urinaire, et rares au niveau rétro péritonéal.Leur prévalence parmi les tumeurs rétropéritonéales primitives a été estimée entre de 0,5 à 1,2%. Une situation qui conduit à des erreurs de diagnostic.

Apreçamento de opções de IDI usando o modelo CIR

Directory of Open Access Journals (Sweden)

José Santiago Fajardo Barbachan

2003-06-01

Full Text Available A opção de IDI da BM&F possui características peculiares que torna o seu apreçamento diferente das opções de taxa de juros mais comuns, como as de títulos de renda fixa. Este artigo desenvolve uma fórmula para apreçamento dessas opções de IDI, utilizando a precificação livre de arbitragem. O modelo utilizado considera apenas um fator estocástico: a taxa de juros livre de risco de curto prazo. A equação diferencial usada para modelar o comportamento da taxa de juros é a do modelo CIR (COX INGERSOLL & ROSS, 1985, que possui reversão à média e não permite a existência de taxas de juros nominais negativas. Também é feita uma estimação dos parâmetros do modelo proposto baseando-se em dados históricos, para então comparar o preço teórico da opção baseado nestes parâmetros com os preços de mercado e com o preço teórico considerando a modelagem de Vasicek (1977.The IDI option from the BM&F (Commodities and Futures Exchange has unusual characteristics, that make its pricing different from common interest rate options. This paper develops a closed form formula for the pricing of these IDI options, using an arbitrage-free pricing approach. The model used considers only one stochastic factor: the short-term risk-free interest rate. The differential equation used to model the behavior of the interest rate comes from the CIR (COX INGERSOLL & ROSS, 1985 model, which has mean reversion property and does not allow negative nominal interest rates. It is also done a parameter estimation of the proposed model based on historic data, and then compares the theoretical price of the option based on these parameters with the market price and with the theoretical price considering the Vasicek (1977 model.

Análise do efeito não linear do patrimônio líquido no apreçamento de fundos de investimento em ações

Directory of Open Access Journals (Sweden)

Paulo Rogério Faustino Matos

2012-01-01

Full Text Available Este artigo faz uso do Capital Asset Pricing Model (CAPM, em sua versão canônica e com extensões não lineares, visando a apreçar um painel de 75 fundos de investimento em ações no Brasil, ao longo dos últimos 11 anos. O resultado sugere que a versão linear desse arcabouço não seja capaz de apreçar ou de prever retornos reais de fundos que possuam elevados patrimônio líquido (PL e outperformance, em relação ao índice da Bolsa de Valores de São Paulo (Ibovespa, corroborando evidências anteriores. A versão não linear com thresholds baseados no PL parece lidar melhor com a questão de alfas de Jensen significativos, apesar de ser estatisticamente indicada apenas para poucos fundos com elevado PL, mas baixa outperformance. Essa é uma evidência de que, apesar de o tamanho influenciar na gestão e, possivelmente, na performance de um fundo, a modelagem de apreçamento desse efeito deve ser feita linearmente.

A MARS and MIDAS Linked Accident Simulation for Large LOCA in APR1400

International Nuclear Information System (INIS)

Choi, Young; Kim, K. R.; Kim, D. H.; Chung, B. D.

2006-01-01

A linked calculation utilizing the design-basis code MARS and the severe accident code MIDAS has been accomplished for a station blackout simulation in APR1400. The MARS code was developed by using the RELAP3/MOD3 and COBRA-TF codes, while the MIDAS code is currently under a development process using the MELCOR code. The objectives of this paper are to explain how to identify the MAR-MIDAS linked calculation outlines and the technical problems, including the MARS data transfer method, the MIDAS input generation works and so on. For the performance verification of the MARS-MIDAS linked calculation, the MARS, MIDAS and their linkage system are run independently for the same initiating event, so that their data can be compared with each other after the selection of proper variables

Case report

African Journals Online (AJOL)

ebutamanya

12 juin 2015 ... L'exérèse de la masse était laborieuse sur le plan profond car la lésion était très adhérente au niveau du sternum. Une partie du périoste et de l'os spongieux ont été enlevées. Cette ablation nécessitait une hémostase minutieuse car la tumeur était hypervascularisée. La tumeur était de consistance ferme, ...

Analysis on Containment Response Following a LBLOCA of APR1400

International Nuclear Information System (INIS)

Han, Kyu Hyun

2016-01-01

The predictions are in good agreements with the final safety analysis report, which implies the containment integrity is maintained during or after an accident like loss of coolant accident. In this study, the CONTEMPT-LT/028 was used to calculate the pressure and temperature, and in the follow-up study, CONTAIN 2.0 will be used for the pressure and temperature predictions in APR1400 reactors. Shin-Hanul Units 1 and 2 may possess different characteristics of peak pressure and temperature in containment following a large break loss-of-coolant-accident. To assess the important performance independently and to compare with prediction results presented in the final safety analysis report (FSAR) of Shin-Hanul Units 1 and 2 might be helpful to regulatory review for identifying validity of the FSAR. The end of blowdown (EOB) time during a LOCA could largely affect the peak pressure and temperature in the containment. This paper provides CONTEMPT-LT/028 prediction of the peak pressure and temperature of Shin-Hanul Units 1 and 2 following a large break loss-of-coolant-accident and compares with licensee's prediction results.

Analysis on Containment Response Following a LBLOCA of APR1400

Energy Technology Data Exchange (ETDEWEB)

Han, Kyu Hyun [KINS, Daejeon (Korea, Republic of)

2016-05-15

The predictions are in good agreements with the final safety analysis report, which implies the containment integrity is maintained during or after an accident like loss of coolant accident. In this study, the CONTEMPT-LT/028 was used to calculate the pressure and temperature, and in the follow-up study, CONTAIN 2.0 will be used for the pressure and temperature predictions in APR1400 reactors. Shin-Hanul Units 1 and 2 may possess different characteristics of peak pressure and temperature in containment following a large break loss-of-coolant-accident. To assess the important performance independently and to compare with prediction results presented in the final safety analysis report (FSAR) of Shin-Hanul Units 1 and 2 might be helpful to regulatory review for identifying validity of the FSAR. The end of blowdown (EOB) time during a LOCA could largely affect the peak pressure and temperature in the containment. This paper provides CONTEMPT-LT/028 prediction of the peak pressure and temperature of Shin-Hanul Units 1 and 2 following a large break loss-of-coolant-accident and compares with licensee's prediction results.

The study of the distribution of Ca{sup 45} with time in the newborn rat by the autoradiography method at - 195 deg; Etude de la distribution du {sup 45}Ca en fonction du temps chez le rat nouveau-ne par la methode d'autoradiographie a -195 deg

Energy Technology Data Exchange (ETDEWEB)

Kellershohn, C; Pellerin, P [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1961-07-01

Ca{sup 45} metabolism has been studied as a function of time by autoradiography at -195 deg. C in the new-born rat after sub-epidermal dorsal injected of 20 micro-curies per animal. This study confirms: 1) The existence of a rapidly exchangeable calcium bone fraction; 2) A considerable intestinal excretion of radio-calcium, much greater than the urinary elimination; 3) A gradual transfer of the activity for the long bones of the epiphyseal to the diaphyseal regions during growth, together with secondary modifications during ossification. (author) [French] Le metabolisme du {sup 45}Ca est etudie en fonction du temps par autoradiographie a -195 deg. C, chez le rat nouveau-ne apres injection sous-epidermique dorsale de 20 microcuries par animal. Cette etude confirme: 1) l'existence d'une fraction calcique osseuse rapidement echangeable; 2) une excretion intestinale considerable du radiocalcium, tres superieure a l'elimination urinaire; 3) un transfert progressif de l'activite pour les os longs des regions epiphysaires aux regions diaphysaires au cours de la croissance, ainsi que les remaniements secondaires au cours de l'ossification. (auteur)

Real-time PCR quantification and diversity analysis of the functional genes aprA and dsrA of sulfate-reducing bacteria in marine sediments of the Peru continental margin and the Black Sea

OpenAIRE

Axel eSchippers; Anna eBlazejak

2011-01-01

A quantitative, real-time PCR (Q-PCR) assay for the functional gene adenosine 5´-phosphosulfate reductase (aprA) of sulfate-reducing bacteria (SRB) was designed. This assay was applied together with described Q-PCR assays for dissimilatory sulfite reductase (dsrA) and the 16S rRNA gene of total Bacteria to marine sediments from the Peru margin (0 – 121 meters below seafloor (mbsf)) and the Black Sea (0 – 6 mbsf). Clone libraries of aprA show that all isolated sequences originate from SRB...

Molecular analysis of the diversity of sulfate-reducing and sulfur-oxidizing prokaryotes in the environment, using aprA as functional marker gene.

Science.gov (United States)

Meyer, Birte; Kuever, Jan

2007-12-01

The dissimilatory adenosine-5'-phosphosulfate reductase is a key enzyme of the microbial sulfate reduction and sulfur oxidation processes. Because the alpha- and beta-subunit-encoding genes, aprBA, are highly conserved among sulfate-reducing and sulfur-oxidizing prokaryotes, they are most suitable for molecular profiling of the microbial community structure of the sulfur cycle in environment. In this study, a new aprA gene-targeting assay using a combination of PCR and denaturing gradient gel electrophoresis is presented. The screening of sulfate-reducing and sulfur-oxidizing reference strains as well as the analyses of environmental DNA from diverse habitats (e.g., microbial mats, invertebrate tissue, marine and estuarine sediments, and filtered hydrothermal water) by the new primer pair revealed an improved microbial diversity coverage and less-pronounced template-to-PCR product bias in direct comparison to those of the previously published primer set (B. Deplancke, K. R. Hristova, H. A. Oakley, V. J. McCracken, R. Aminov, R. I. Mackie, and H. R. Gaskins, Appl. Environ. Microbiol. 66:2166-2174, 2000). The concomitant molecular detection of sulfate-reducing and sulfur-oxidizing prokaryotes was confirmed. The new assay was applied in comparison with the 16S rRNA gene-based analysis to investigate the microbial diversity of the sulfur cycle in sediment, seawater, and manganese crust samples from four study sites in the area of the Lesser Antilles volcanic arc, Caribbean Sea (Caribflux project). The aprA gene-based approach revealed putative sulfur-oxidizing Alphaproteobacteria of chemolithoheterotrophic lifestyle to have been abundant in the nonhydrothermal sediment and water column. In contrast, the sulfur-based microbial community that inhabited the surface of the volcanic manganese crust was more complex, consisting predominantly of putative chemolithoautotrophic sulfur oxidizers of the Betaproteobacteria and Gammaproteobacteria.

Signoles Aude, Le Hamas au pouvoir et après ?, Toulouse, Editions Milan, 2006.

Directory of Open Access Journals (Sweden)

Jean-François Legrain

2007-11-01

Full Text Available Dans les étroites limites imposées par la collection (absence totale de notes et de bibliographie, 112 p. en format réduit, le petit livre d’Aude Signoles, Le Hamas au pouvoir et après ?, commence à combler un vide de l’édition française. Le seul livre jusque là disponible en français et entièrement consacré à Hamas remonte à 7 années maintenant ; doté de nombreuses erreurs factuelles et faisant comme si Hamas était apparu avec l’autonomie des années 1990, il ignorait tout de son passé d’Ass...

Variability of nursing care by APR-DRG and by severity of illness in a sample of nine Belgian hospitals.

Science.gov (United States)

Pirson, Magali; Delo, Caroline; Di Pierdomenico, Lionel; Laport, Nancy; Biloque, Veronique; Leclercq, Pol

2013-10-10

As soon as Diagnosis related Groups (DRG) were introduced in many hospital financing systems, most nursing research revealed that DRG were not very homogeneous with regard to nursing care. However, few studies are based on All Patient refined Diagnosis related Groups (APR-DRGs) and few of them use recent data. Objectives of this study are: (1) to evaluate if nursing activity is homogeneous by APR-DRG and by severity of illness (SOI) (2) to evaluate the outlier's rate associated with the nursing activity and (3) to compare nursing cost homogeneity per DRG and SOI. Study done in 9 Belgian hospitals on a selection of APR-DRG with more than 30 patients (7 638 inpatient stays). The evaluation of the homogeneity is based on coefficients of variation (CV). The 75th percentile + 1.5 × inter-quartile range was used to select high outliers. 25th percentile -1.5 × inter-quartile range was used to select low outliers. Nursing costs per ward were distributed on inpatient stays of each ward following two techniques (the LOS vs. the number of nursing care minutes per stay). The homogeneity of LOS by DRG and by SOI is relatively good (CV: 0.56). The homogeneity of the nursing activity by DRG is less good (CVs between 0.36 and 1.54) and is influenced by nursing activity outliers (high outliers' rate: 5.19%, low outliers' rate: 0.14%). The outlier's rate varies according to the studied variable. The high outliers' rate is higher for nursing activity than for LOS. The homogeneity of nursing costs is higher when costs are based on the LOS of patients than when based on minutes of nursing care (CVs between 0.26 and 1.46 for nursing costs based on LOS and between 0.49 and 2.04 for nursing costs based on minutes of nursing care). It is essential that the calculation of nursing cost by stay and by DRG for hospital financing purposes was based on nursing activity data, that more reflect resources used in wards, and not on LOS data. The only way to obtain this information is

L'Islam noir à Bahia d'après les travaux de l'école ethnologique brèsilienne

Directory of Open Access Journals (Sweden)

Roger Bastide

1951-03-01

Full Text Available RICARD (Robert. - L'Islam noir à Bahia d'après les travaux de l'école ethnologique brèsilienne (Primeiro Artigo do Parágrafo Depois da publicação, em frances, do livro de Nina Rodrigues sobre O animismo fetichista dos negros da Bahia e da duas memórias do Piére Etienne, parece que a França pouco tem ouvido falar dos problemas afro-brasileiras.

Response Time Analysis and Test of Protection System Instrument Channels for APR1400 and OPR1000

Energy Technology Data Exchange (ETDEWEB)

Lee, Chang Jae; Han, Seung; Yun, Jae Hee; Baek, Seung Min [Department of Instrumentation and Control System Engineering, KEPCO Engineering and Construction, Daejeon (Korea, Republic of); Lee, Sang Jeong [Department of Electronics Engineering, Chungnam National University, Daejeon (Korea, Republic of)

2015-07-01

Safety limits are required to maintain the integrity of physical barriers designed to prevent the uncontrolled release of radioactive materials in nuclear power plants. The safety analysis establishes two critical constraints that include an analytical limit in terms of a measured or calculated variable, and a specific time after the analytical limit is reached to begin protective action. Keeping with the nuclear regulations and industry standards, satisfying these two requirements will ensure that the safety limit will not be exceeded during the design basis event, either an anticipated operational occurrence or a postulated accident. Various studies on the setpoint determination methodology for the safety-related instrumentation have been actively performed to ensure that the requirement of the analytical limit is satisfied. In particular, the protection setpoint methodology for the advanced power reactor 1400 (APP1400) and the optimized power reactor 1000 (OPR1000) has been recently developed to cover both the design basis event and the beyond design basis event. The developed setpoint methodology has also been quantitatively validated using specific computer programs and setpoint calculations. However, the safety of nuclear power plants cannot be fully guaranteed by satisfying the requirement of the analytical limit. In spite of the response time verification requirements of nuclear regulations and industry standards, it is hard to find the studies on the systematically integrated methodology regarding the response time evaluation. In cases of APR1400 and OPR1000, the response time analysis for the plant protection system is partially included in the setpoint calculation and the response time test is separately performed via the specific plant procedure. The test technique has a drawback which is the difficulty to demonstrate completeness of timing test. The analysis technique has also a demerit of resulting in extreme times that not actually possible. Thus

Response Time Analysis and Test of Protection System Instrument Channels for APR1400 and OPR1000

International Nuclear Information System (INIS)

Lee, Chang Jae; Han, Seung; Yun, Jae Hee; Baek, Seung Min; Lee, Sang Jeong

2015-01-01

Safety limits are required to maintain the integrity of physical barriers designed to prevent the uncontrolled release of radioactive materials in nuclear power plants. The safety analysis establishes two critical constraints that include an analytical limit in terms of a measured or calculated variable, and a specific time after the analytical limit is reached to begin protective action. Keeping with the nuclear regulations and industry standards, satisfying these two requirements will ensure that the safety limit will not be exceeded during the design basis event, either an anticipated operational occurrence or a postulated accident. Various studies on the setpoint determination methodology for the safety-related instrumentation have been actively performed to ensure that the requirement of the analytical limit is satisfied. In particular, the protection setpoint methodology for the advanced power reactor 1400 (APP1400) and the optimized power reactor 1000 (OPR1000) has been recently developed to cover both the design basis event and the beyond design basis event. The developed setpoint methodology has also been quantitatively validated using specific computer programs and setpoint calculations. However, the safety of nuclear power plants cannot be fully guaranteed by satisfying the requirement of the analytical limit. In spite of the response time verification requirements of nuclear regulations and industry standards, it is hard to find the studies on the systematically integrated methodology regarding the response time evaluation. In cases of APR1400 and OPR1000, the response time analysis for the plant protection system is partially included in the setpoint calculation and the response time test is separately performed via the specific plant procedure. The test technique has a drawback which is the difficulty to demonstrate completeness of timing test. The analysis technique has also a demerit of resulting in extreme times that not actually possible. Thus

Effect of School-based Human Papillomavirus (HPV) Vaccination on ...

African Journals Online (AJOL)

... de comportement des pairs positifs. Des obstacles majeurs à l'acceptation du vaccin ont été: les rumeurs et les idées fausses au sujet des effets secondaires possibles, information inadéquate perçue sur le vaccin, et la peur des effets secondaires. Mots clés: adolescentes; connaissances; acceptabilité; vaccin; Ouganda ...

Intervention intégrée quant au risque de diabète après le diabète ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les femmes ayant souffert de diabète sucré de la grossesse, un diabète temporaire qui apparaît pendant la grossesse, présentent un risque élevé de développer le diabète de type 2 après leur grossesse. Cette étude de recherche abordera le problème en Afrique du Sud par l'intermédiaire d'une intervention novatrice au ...

Molecular Analysis of the Diversity of Sulfate-Reducing and Sulfur-Oxidizing Prokaryotes in the Environment, Using aprA as Functional Marker Gene▿ †

Science.gov (United States)

Meyer, Birte; Kuever, Jan

2007-01-01

The dissimilatory adenosine-5′-phosposulfate reductase is a key enzyme of the microbial sulfate reduction and sulfur oxidation processes. Because the alpha- and beta-subunit-encoding genes, aprBA, are highly conserved among sulfate-reducing and sulfur-oxidizing prokaryotes, they are most suitable for molecular profiling of the microbial community structure of the sulfur cycle in environment. In this study, a new aprA gene-targeting assay using a combination of PCR and denaturing gradient gel electrophoresis is presented. The screening of sulfate-reducing and sulfur-oxidizing reference strains as well as the analyses of environmental DNA from diverse habitats (e.g., microbial mats, invertebrate tissue, marine and estuarine sediments, and filtered hydrothermal water) by the new primer pair revealed an improved microbial diversity coverage and less-pronounced template-to-PCR product bias in direct comparison to those of the previously published primer set (B. Deplancke, K. R. Hristova, H. A. Oakley, V. J. McCracken, R. Aminov, R. I. Mackie, and H. R. Gaskins, Appl. Environ. Microbiol. 66:2166-2174, 2000). The concomitant molecular detection of sulfate-reducing and sulfur-oxidizing prokaryotes was confirmed. The new assay was applied in comparison with the 16S rRNA gene-based analysis to investigate the microbial diversity of the sulfur cycle in sediment, seawater, and manganese crust samples from four study sites in the area of the Lesser Antilles volcanic arc, Caribbean Sea (Caribflux project). The aprA gene-based approach revealed putative sulfur-oxidizing Alphaproteobacteria of chemolithoheterotrophic lifestyle to have been abundant in the nonhydrothermal sediment and water column. In contrast, the sulfur-based microbial community that inhabited the surface of the volcanic manganese crust was more complex, consisting predominantly of putative chemolithoautotrophic sulfur oxidizers of the Betaproteobacteria and Gammaproteobacteria. PMID:17921272

Evolution of glycaemia in the rat after gamma irradiation; Evolution de la glycemie chez le rat apres irradiation gamma

Energy Technology Data Exchange (ETDEWEB)

Marble, G; Frossard, H; Breuil, L; Engler, R [Commissariat a l' Energie Atomique, Fontenay aux Roses (France). Centre d' Etudes Nucleaires

1965-07-01

The study of glycaemia variations in the rat after irradiation has made it possible to observe not only a premature hyperglycemia but also a belated hypoglycemia whose importance and subsequent evolution seem to depend on the dose given to the animal. (authors) [French] L'etude des variations de la glycemie du rat apres irradiation a permis de noter une hyperglycemie precoce mais egalement une hypoglycemie retardee dont l'amplitude et l'evolution seraient fonction de la dose delivree a l'animal. (auteurs)

Aircraft Impact Assessment of APR1400 Reactor Containment Building

International Nuclear Information System (INIS)

Moon, Il Hwan; Kim, Do Yeon; Kim, Jae Hee; Kim, Sang Yun

2011-01-01

The implementation of a protection to withstand aircraft impact on safety-related structures and systems is basically based on a probabilistic evaluation for each site, if the licensing body doesn't require a deterministic approach. Existing nuclear power plants in Korea were designed based on the probabilistic approach, and the aircraft impact hazard remained less than a probability of 10 -7 . However, a man-made aircraft impact have been considered as a possible external accident for the nuclear power plant. New plant designs that are to be constructed in the U.S. after July 2009 must consider the effect of impact from a large commercial aircraft according to the requirements of 10 CFR 50.150. Especially, Reactor Containment Building (RCB) housing the safety-related equipment and fuels should be protected safely against aircraft crash without perforation and scabbing failure of external wall. APR1400 RCB is constructed as a prestressed concrete containment vessel (PCCV) which is surrounded by the auxiliary building housing additional safety-related equipment and other systems. In this study, the aircraft impact analyses for the RCB are carried out using Riera forcing function and aircraft model. Considered external wall thickness is 4 ft 6 in. for the cylindrical wall and 4 ft for the dome. Actual strengths of concrete and steel are considered as the material properties. For these analyses, the dynamic increment factor and concrete aging effect are considered in accordance with NEI 07-13(2011)

O après-coup e a reconsolidação da memória

Directory of Open Access Journals (Sweden)

Graziele Luiza Barizon Scopel Gerbasi

2015-04-01

Full Text Available Em diferentes áreas do conhecimento é reconhecido que a memória está sujeita a transformações ao longo do tempo. Partindo desse pressuposto, o objetivo do presente estudo é apresentar uma discussão compreendendo a ideia de que nossas recordações são suscetíveis a transformações e a concepção de après-coup. Há o delineamento de algumas ideias acerca da temporalidade em Psicanálise e do mecanismo de reconsolidação da memória segundo as Neurociências. Utilizando-se tais conceitos, evidenciou-se a viabilidade de se pensar uma interlocução entre a Psicanálise e as Neurociências.

La métaplasie osteoide de l'endomètre après une grossesse à terme: à propos d'un cas rare

Science.gov (United States)

Jayi, Sofia; Bouguern, Hakima; Fatemi, Hind; Chaara, Hikmat; Laamarti, Afaf; Melhouf, Aabdelilah

2013-01-01

La métaplasie ostéoïde de l'endomètre (MOE) est une entité rare correspondant à la présence de tissu osseux dans l'endomètre, elle est le plus souvent diagnostiquée dans un contexte d'infertilité secondaire faisant suite à une grossesse interrompue. Même si plusieurs facteurs de risque sont répertoriés, sa physiopathologie reste mal connue et sa traduction clinique est très variable. Nous rapportons un cas de MOE apparu suite à un curetage pour rétention placentaire en post-partum. Le diagnostic a été suspecté par l'hystéroscopie et confirmé par l’étude anatomopathologique. A notre connaissance c'est le premier cas décrit suite à un accouchement à terme. A travers notre cas et à la lumière d'une revue de la littérature nous insistons sur les caractéristiques épidémiologiques, physiopathologiques, cliniques et para cliniques de cette entité rare, dont la connaissance est primordiale pour un diagnostic sûr et par conséquent un traitement adapté permettant souvent de récupérer la fertilité de la patiente. PMID:23898363

Behaviour of BF{sub 3} counters after in-pile irradiation; Comportement de compteurs a BF{sub 3} apres irradiation dans un reacteur

Energy Technology Data Exchange (ETDEWEB)

Verdant, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-07-01

The behaviour of a proportional BF{sub 3}LCT 14 NE 31 counter with aluminium cathode has been studied after irradiation from 10{sup 5} to 10{sup 6} n.cm{sup -2} in the swimming-pool reactor Triton. The pulse spectrum was only slightly modified by two successive irradiations at 10{sup 15} n.cm{sup -2}, and 1 hour after the end of the irradiation the decrease in sensitivity reached 10 to 20 per cent. One hour after irradiation at 10{sup 16} n.cm{sup -2} this decrease was 20 per cent but the pulse spectrum was affected. The advantages of an aluminium cathode with respect to a standard counter using a copper cathode and irradiated under the same conditions are given. Beforehand, it had been established that the limit for use of an aluminium-cathode counter in the presence of {gamma} radiation is about 200 R.h{sup -1}. (author) [French] Le comportement d'un compteur proportionnel a BF-3LCT 14 NE 31, a cathode d'aluminium, a ete etudie apres des irradiations de 10{sup 5} a 10{sup 6} n.cm{sup -2} dans la pile-piscine TRITON. Deux irradiations successives de 10{sup 15} n.cm{sup -2} ont peu modifie le spectre des impulsions et 1 heure apres la fin de l'exposition la perte de sensibilite etait de 10 a 20 pour cent. Une heure apres une irradiation de 10{sup 16} n.cm{sup -2}, cette perte etait de 20 pour cent mais le spectre d'impulsions etait perturbe. L'avantage d'une cathode en aluminium est mis en evidence par comparaison avec un compteur standard a cathode de cuivre irradie dans les memes conditions. En preliminaire, on avait etabli que la limite d'utilisation d'un compteur a cathode d'aluminium en presence de rayonnements {gamma} etait de l'ordre de 200 R.h{sup -1}. (auteur)

Failure Mode and Effect Analysis of the Application Software of the Safety-critical I and C System in APR1400

Energy Technology Data Exchange (ETDEWEB)

Kim, Koheun; Kim, Yong geul; Choi, Woong seok; Sohn, Se do [KEPCO Engineering and Construction, Daejeon (Korea, Republic of)

2016-10-15

In APR1400, the computer software hazard analysis is performed by hazard and operability analysis (HAZOP) method. Meanwhile, HAZOP has its limitation and cannot be considered better than fault tree analysis (FTA) or failure mode and effect (FMEA) analysis. HAZOP assumes that the system has been carefully studied, and all possible hazards, their effects or consequences and remedies are incorporated in the system. But incorporating every possible event in the design is impossible. In this light, this paper attempts to use FMEA method for evaluating the risk for safety-critical instrumentation and control (I and C) system software for NPP which is more practically than HAZOP. It is possible because the software failures are due to systematic faults that causing simultaneous failure in multiple division when the triggering event happens. This analysis is applied to safety-critical system of Shin-Hanul units 1 and 2 NPP, i.e., APR1400. Through SFMEA, the critical software failure modes and tasks that could result in CCF are identified and also evaluated to determine the associated risk level (e.g. high or intermediate or low) based on the failure effect. Biggest benefit from this analysis comparing with HAZOP is it can reveal the possible weak points and provide the guidance to the V and V team by helping to generate the test cases.

Evaluation of Fluorine-18 as a Scanning Agent for Intracranial Tumours; Emploi du Fluor-18 en Scintigraphy des Tumeurs Intracraniennes; Otsenka Ftora-18 kak skenniruyushchego agenta dlya vnutricherepnykh opukholej; Examen de las Caracteristicas del Fluor-18 como Agente de Exploracion de los Tumores Intracraneales

Energy Technology Data Exchange (ETDEWEB)

Entzian, W.; Aronow, S.; Soloway, A. H.; Sweet, W. H. [Massachusetts General Hospital, Boston, MA (United States)

1964-10-15

irradiation de Li{sub 2}Co{sub 3} par des neutrons thermiques ({sup 6}Li (n, {alpha}){sup 3}H, {sup 15}O({sup 3}H, n){sup 18}F). Il ressort d'etudes faites sur des tissus de souris presentant des ependymomes implantes par greffes sous-cutanees que le fluorure de sodium marque (Na{sup 18}F) se concentre de maniere excessive dans les os et qu'il ne convient donc pas pour explorer le cerveau. Par contre, on a constate que le fluoborate de potassium marque (KBF{sup 18}{sub 4}) se concentrait nettement plus dans les tumeurs que dans le tissu normal du cerveau, les rapports de concentration allant de 8 a 11. Aucune concentration excessive n'a ete observee dans d'autres organes, tant chez les souris que chez les chats. Les auteurs ont fait des etudes de toxicite sur des souris et des lapins pour 300 mgAg et 120 mgAg' respectivement. Aucun effet nocif n'a ete observe tant que le pH de la solution etait maintenu a une valeur physiologique. Les quantites de substance necessaire pour proceder a la scintigraphie du sujet etaient inferieures a 0,5 mgAg de poids du corps. Une etude clinique comparative menee sur 10 patients, qui ont tous ete examines a l'aide de KBF{sup 18}{sub 4} et d'autres agents radioisotopiques, a confirme la conclusion d'Askenasy et autres: ce compose est utile pour localiser les tumeurs du cerveau. On a fait des injections intraveineuses dans des conditions optimales 30 min avant la scintigraphie, a raison de 15 {mu}c/kg de poids du corps. Des echantillons de tissus de tumeur et de tissus normaux du cerveau ont ete preleves sur un malade qui subissait une operation. Le rapport de concentration etait de 3,5. Bien que ce rapport soit inferieur a celui qui avait ete observe chez la souris, il n'en demeure pas moins convenable. L'examen d'echantillons de sang preleves sur des malades a divers intervalles apres l'injection a permis d'etablir une courbe d'elimination du sang a deux constantes de temps. La premiere etait tres rapide et la seconde plus lente, ce qui est

The role of the Northern Sea Route in the development of floating nuclear power sources and prospects of cooperation with the EU countries, BRICS and APR

International Nuclear Information System (INIS)

Shadrin, A.P.; Ignat'ev, V.S.; Ivanov, V.A.

2015-01-01

The report discusses the construction of a transportable nuclear reactor, which will become the basis for the development of floating nuclear power sources on the Northern Sea Route. In this regard, the prospects of cooperation with the countries of the European Union, BRICS and APR [ru

Measurement techniques of local parameters in the downcomer boiling experiment of APR1400

International Nuclear Information System (INIS)

Lee, Eu Hwak

2004-02-01

In order to investigate boiling phenomena experimentally in the downcomer during LBLOCA with Direct Vessel Injection (DVI), which is a new Safety Injection System (SIS) of Advanced Power Reactor 1400 MW (APR1400), several parameters should be measured through the verification of their applicability. In this study, measurement techniques of the parameters are developed for the downcomer boiling experiment; local phase velocities, local void fraction and heat flux from the heated wall. The experiment has been performed with the heated wall, which has a thickness of 8.2 cm and a height of 32.5 cm and made of the same material as the prototype (APR1400) with chrome coating against rusting. The newly developed pitot tube is applied to the measurement of local liquid velocity and its calibration curve is obtained experimentally with the consideration of the effect according to water temperature and hole size changes. The developed pitot tube measures the local liquid velocity with 0.69 % deviation and it is confirmed that the water temperature and geometrical change does not affect the calibration curve. The high-speed camera and commercial software are used to measure the local vapor velocity with the accuracy of 0.06 m/sec per pixel and the procedure is confirmed in the present study. It turns out that the vapor velocity is insensitive to void size. High-speed camera and image processing are used to measure the local void fraction with the determined intensity criterion for distinguishing each phase and the results are compared with the bulk void fraction by differential pressure transmitters. In the actual experiment, the developed method is applied successfully and the results show that the criterion of intensity has little effect on local void fraction. And, it is observed that the tendency between the measured local and bulk void faction is maintained with time. In order to measure heat flux from the heated wall, two heat flux measurement techniques are developed

Analysis of steam condensation in APR1400 IRWST for loss of coolant accident

Energy Technology Data Exchange (ETDEWEB)

Oh, Young Suk

2006-02-15

The In-Containment Refueling Water Storage Tank (IRWST) of APR1400 is installed at the bottom of containment building to promote the plant safety functions during an accident. This design feature brings about uncertainty factors which may necessitate conventional prediction of temperature and pressure of containment building improved or revised when an accident occurs. The hot steam which is released from RCS break enters the IRWST through four Pressure Relief Dampers (PRDs). It is expected to be condensed with water stored in IRWST, in which water is colder than incoming steam. The purpose of this study is to investigate the influence of IRWST and pressure relief damper on back pressure and temperature in APR1400 containment codes such as CONTEMPT-LT and GOTHIC. The comparison of codes showed that GOTHIC code be more appropriate for the prediction of containment pressure and temperature under the condition of steam condensation occurring in confined water pool. Especially, the GOTHIC has superior capability to treat multi-compartmentalized geometry This study developed one-compartment (single) model, two-compartment (separated) model, and three-dimension (3-D) model, respectively. Two compartment model separates the IRWST from the other containment compartments. In 3-D model, only the IRWST is nodalized with Cartesian modeling. The single model is developed for comparison with two-compartment model which can analyze PRD's influence. The separated model for predicting PRD's influence divides the space between containment and IRWST. 3-D model for IRWST was generated because it is not symmetric considering location of sparger, pump, and suction sump. Therefore, IRWST is simulated with not only detailed three-dimensional behavior but also independent flow paths for four PRDs. Many experimental studies for the direct-contact heat transfer in stratified steam water flows, cocurrent or countercurrent, have been performed (Segev et al., 1981; Lim et al., 1981

Analysis of steam condensation in APR1400 IRWST for loss of coolant accident

International Nuclear Information System (INIS)

Oh, Young Suk

2006-02-01

The In-Containment Refueling Water Storage Tank (IRWST) of APR1400 is installed at the bottom of containment building to promote the plant safety functions during an accident. This design feature brings about uncertainty factors which may necessitate conventional prediction of temperature and pressure of containment building improved or revised when an accident occurs. The hot steam which is released from RCS break enters the IRWST through four Pressure Relief Dampers (PRDs). It is expected to be condensed with water stored in IRWST, in which water is colder than incoming steam. The purpose of this study is to investigate the influence of IRWST and pressure relief damper on back pressure and temperature in APR1400 containment codes such as CONTEMPT-LT and GOTHIC. The comparison of codes showed that GOTHIC code be more appropriate for the prediction of containment pressure and temperature under the condition of steam condensation occurring in confined water pool. Especially, the GOTHIC has superior capability to treat multi-compartmentalized geometry This study developed one-compartment (single) model, two-compartment (separated) model, and three-dimension (3-D) model, respectively. Two compartment model separates the IRWST from the other containment compartments. In 3-D model, only the IRWST is nodalized with Cartesian modeling. The single model is developed for comparison with two-compartment model which can analyze PRD's influence. The separated model for predicting PRD's influence divides the space between containment and IRWST. 3-D model for IRWST was generated because it is not symmetric considering location of sparger, pump, and suction sump. Therefore, IRWST is simulated with not only detailed three-dimensional behavior but also independent flow paths for four PRDs. Many experimental studies for the direct-contact heat transfer in stratified steam water flows, cocurrent or countercurrent, have been performed (Segev et al., 1981; Lim et al., 1981; Kim and

Thermal Decomposition of Methane. Bibliographic Study and Proposal of a Mechanism Décomposition thermique du méthane. Étude bibliographique. Proposition de mécanisme

Directory of Open Access Journals (Sweden)

Billaud F.

2006-11-01

Full Text Available This review article gives the state-of-the-art of the upgrading of methane by the purely thermal route. It sums up the principal research since 1960 by giving, for each project, the operating conditions, type of reactor and the main results (order, inhibition of the reaction. It also comments on the reactions and the elementary processes written as well as the contribution of new kinetic constants. It emphasizes the effects of temperature, of dilution by inert gases, by hydrogen, by ethane and by water as well as the wall effects. After analyzing a great many publications dealing with the thermal decomposition of methane, this article attempts to give a mechanism and the major stages for which there seems to be a consensus among different authors and that account for the formation of hydrogen, ethane, ethylene, propene and acetylene. This mechanism can be broken down as follows :(a Primary formation of ethane and hydrogen. (b Secondary reactions of ethane. (c Secondary reactions of ethylene. (d Secondary reactions of acetylene. (e Secondary reactions of propene. This mechanism has also made possible the excellent simulation of the formation of all the above-mentioned products. However, concerning the formation of liquid hydrocarbons and coke, there is no coherent mechanism capable of simulating their formation. Cet article de revue fait le point sur la valorisation du méthane par voie purement thermique. Nous avons résumé les principaux travaux depuis 1960 en présentant pour chaque étude les différentes conditions opératoires, le type de réacteur, les principaux résultats (ordre, inhibition de la réaction. Nous avons également commenté les réactions et processus élémentaires écrits ainsi que l'apport de nouvelles constantes cinétiques. Nous soulignons également les effets de la température, de la dilution par des gaz inertes, par l'hydrogène, par l'éthane et par l'eau ainsi que les effets de parois. Après analyse du grand

Development of a Desktop Simulator for APR1400 Nuclear Power Plant

International Nuclear Information System (INIS)

Lee, J. B.

2016-01-01

It is essential for utilities to possess a full-scope simulator for operator training and operation test for operators. But it is very expensive and sometimes lack of fidelity if processes of developing the simulator and designing the plant are in parallel. It is due to the situation that simulator development stage sometimes precedes the plant design stage and modifications may occur to the design of the plant in construction stage. In an attempt to build a low cost and efficient simulator, a desktop simulator has been developed. This model is described herein. Using desktop simulators for training operators is an efficient method for familiarizing operators with their plant’s operation. A low cost and efficient desktop simulator for APR1400 has been developed, and brief features are introduced here. It is configured to mimic a full-scale simulator, and can be used for operators to be familiarized to their plant’s operation. Since the size of the simulator is small enough to be fit in a desk, it can be used in a classroom or in an office at any time. It can also be used to evaluate design changes or modifications of the plant before implementing them to the plant

Development of a Desktop Simulator for APR1400 Nuclear Power Plant

Energy Technology Data Exchange (ETDEWEB)

Lee, J. B. [KHNP Central Research Institute, Daejeon (Korea, Republic of)

2016-10-15

It is essential for utilities to possess a full-scope simulator for operator training and operation test for operators. But it is very expensive and sometimes lack of fidelity if processes of developing the simulator and designing the plant are in parallel. It is due to the situation that simulator development stage sometimes precedes the plant design stage and modifications may occur to the design of the plant in construction stage. In an attempt to build a low cost and efficient simulator, a desktop simulator has been developed. This model is described herein. Using desktop simulators for training operators is an efficient method for familiarizing operators with their plant’s operation. A low cost and efficient desktop simulator for APR1400 has been developed, and brief features are introduced here. It is configured to mimic a full-scale simulator, and can be used for operators to be familiarized to their plant’s operation. Since the size of the simulator is small enough to be fit in a desk, it can be used in a classroom or in an office at any time. It can also be used to evaluate design changes or modifications of the plant before implementing them to the plant.

Validation of the All Patient Refined Diagnosis Related Group (APR-DRG) Risk of Mortality and Severity of Illness Modifiers as a Measure of Perioperative Risk.

Science.gov (United States)

McCormick, Patrick J; Lin, Hung-Mo; Deiner, Stacie G; Levin, Matthew A

2018-03-22

The All Patient Refined Diagnosis Related Group (APR-DRG) is an inpatient visit classification system that assigns a diagnostic related group, a Risk of Mortality (ROM) subclass and a Severity of Illness (SOI) subclass. While extensively used for cost adjustment, no study has compared the APR-DRG subclass modifiers to the popular Charlson Comorbidity Index as a measure of comorbidity severity in models for perioperative in-hospital mortality. In this study we attempt to validate the use of these subclasses to predict mortality in a cohort of surgical patients. We analyzed all adult (age over 18 years) inpatient non-cardiac surgery at our institution between December 2005 and July 2013. After exclusions, we split the cohort into training and validation sets. We created prediction models of inpatient mortality using the Charlson Comorbidity Index, ROM only, SOI only, and ROM with SOI. Models were compared by receiver-operator characteristic (ROC) curve, area under the ROC curve (AUC), and Brier score. After exclusions, we analyzed 63,681 patient-visits. Overall in-hospital mortality was 1.3%. The median number of ICD-9-CM diagnosis codes was 6 (Q1-Q3 4-10). The median Charlson Comorbidity Index was 0 (Q1-Q3 0-2). When the model was applied to the validation set, the c-statistic for Charlson was 0.865, c-statistic for ROM was 0.975, and for ROM and SOI combined the c-statistic was 0.977. The scaled Brier score for Charlson was 0.044, Brier for ROM only was 0.230, and Brier for ROM and SOI was 0.257. The APR-DRG ROM or SOI subclasses are better predictors than the Charlson Comorbidity Index of in-hospital mortality among surgical patients.

Localisation buccale d’un lymphome de Burkitt: à propos d’un cas

Science.gov (United States)

Kissi, Lamia; El Bouihi, Rajaa; Lamchahab, Mouna; Alaoui, Ahmed; Benyahya, Ihsane

2017-01-01

Le lymphome de Burkitt (LB) est une forme de lymphome malin non-Hodgkinien qui provient de l'évolution maligne et de la prolifération de cellules lymphoïdes de type B. Le diagnostic positif repose sur la biopsie d'une masse tumorale ou la ponction de la moelle osseuse révélant la présence de cellules tumorales. Le cas rapporté est celui d'un jeune homme d'une vingtaine d'années qui a été adressé pour des tuméfactions gingivales évoluant depuis 1 mois suite à des extractions dentaires. L'examen anatomopathologique après biopsie complété par l'immunohistochimie conclut à un lymphome de Burkitt. La prise en charge a consisté en une chimiothérapie. Bien que rare, le lymphome de Burkitt est une tumeur agressive qui représente un véritable problème de santé publique d'où la place importante qu'occupe le médecin dentiste dans le diagnostic précoce afin de permettre une prise en charge rapide et appropriée seule garante de la guérison. PMID:28451040

Fatou, Julia, Montel le grand prix des sciences mathématiques de 1918, et après

CERN Document Server

Audin, Michèle

2009-01-01

Comment Fatou et Julia ont inventA(c) ce que la (TM)on appelle aujourda (TM)hui les ensembles de Julia, avant, pendant et aprA]s la premiA]re guerre mondiale? La (TM)histoire est racontA(c)e, avec ses mathA(c)matiques, ses conflits, ses personnalitA(c)s. Elle est traitA(c)e A partir de sources nouvelles, et avec rigueur. On pourra sa (TM)y initier A la (TM)itA(c)ration des fractions rationnelles et A la dynamique complexe (ensembles de Julia, de Mandelbrot, ensembles-limites). Qui A(c)taient Pierre Fatou, Gaston Julia, Paul Montel? On y trouvera en particulier des informations sur un mathA(c)m

Improved Design of PECS to reduce Flow Instability for EU-APR1400

International Nuclear Information System (INIS)

Hwang, Do Hyun; Lee, Keunsung

2014-01-01

For EU-APR1400, PECS (Passive Ex-vessel corium retaining and Cooling System), so-called core catcher, was adopted to keep the integrity of basemat in containment by preventing MCCI (Molten Core Concrete Interaction) through retaining core debris and cooling corium outside the reactor vessel. In this paper, the improved design of PECS is presented to increase coolability by reducing flow instability in the region of cooling channel. In this paper, flow instability analysis was carried out using CFD code to find out the most improved design of PECS, which is to increase coolability by reducing bubble entrainment in the region of cooling channel. The reduction of bubble entrainment in the downcomer facilitates higher mass flow rates in the downcomer. Among presented four designed for the downcomer of PECS, the superstep design shows the highest mass flow rate and the lowest gas holdup in the downcomer as well as in the cooling channel. Compared with the existing design, the elimination of the horizontal part and the addition of an extra space above the vertical entrance to the downcomer seem to help the separation of the vapor

Les voies d'eau de l'espoir | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

15 déc. 2010 ... Le prochain objectif consistait à procéder au revêtement d'un canal secondaire dans la zone d'irrigation. Comme c'est le cas de tous les canaux secondaires non ... Pour sa part, l'équipe de recherche a versé 51 000 EGP provenant du budget du projet. Le projet d'amélioration du canal a débuté dans un ...

Etude de l.inocuite et de l.acceptabilite du sulfate de cellulose (SC ...

African Journals Online (AJOL)

L.objectif principal de l.étude était d.évaluer les effets secondaires locaux et systémiques de l.application vaginale de plusieurs doses de gel de sulfate de cellulose à 6%. L.objectif secondaire était d.en évaluer l.acceptabilité par les participantes. L.autorisation pour mener l.étude a été obtenue du Ministère de la Santé ...

Fuel assembly design for APR1400 with low CBC

Energy Technology Data Exchange (ETDEWEB)

Hah, Chang Joo, E-mail: changhah@kings.ac.kr [Department of NPP Engineering, KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2015-04-29

APR 1400 is a PWR (Pressurized Water Reactor) with rated power of 3983 MWth and 241 assemblies. Recently, demand for extremely longer cycle up to 24 months is increasing with challenge of higher critical boron concentration (CBC). In this paper, assembly design method of selecting Gd-rods is introduced to reduce CBC. The purpose of the method is to lower the critical boron concentration of the preliminary core loading pattern (PLP), and consequently to achieve more negative or less positive moderator temperature coefficient (MTC). In this method, both the ratio of the number of low-Gd rod to the number of high-Gd rod (r) and assembly average Gd wt% (w) are the decision variables. The target function is the amount of soluble boron concentration reduction, which can be converted to Δk{sub TARGET}. A set of new designed fuel assembly satisfies an objective function, min [f=∑{sub i}(Δk{sub FA}−Δk{sub i})], and enables a final loading pattern to reach a target CBC. The constraints required to determine a set of Δk are physically realizable pair, (r,w), and the sum of Δk of new designed assemblies as close to Δk{sub TARGET} as possible. New Gd-bearing assemblies selected based on valid pairs of (r,w) are replaced with existing assemblies in a PLP. This design methodology is applied to Shin-Kori Unit 3 Cycle 1 used as a reference model. CASMO-3/MASTER code is used for depletion calculation. CASMO-3/MASTER calculations with new designed assemblies produce lower CBC than the expected CBC, proving that the proposed method works successful.

PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53

DEFF Research Database (Denmark)

Zandi, Roza; Selivanova, Galina; Christensen, Camilla Laulund

2011-01-01

Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis, necessitating the need to develop new and efficient treatment modalities. PRIMA-1(Met) (p53-dependent reactivation of massive apoptosis), also known as APR-246, is a small molecule, which restores tumor suppressor...... function to mutant p53 and induces cancer cell death in various cancer types. Since p53 is mutated in more than 90% of SCLC, we investigated the ability of PRIMA-1(Met) to induce apoptosis and inhibit tumor growth in SCLC with different p53 mutations....

Analysis for the Effects of Grid Voltage Degradation on APR1400 Operation, Case Study for Egypt

International Nuclear Information System (INIS)

Hassan, Mostafa Ahmed Fouad; Koo, Chang Choong

2015-01-01

Egypt is one of the countries planning to introduce a NPP into its electrical power system. Although the Egyptian power system has sufficient capacity to integrate any commercially available nuclear unit as the total installed capacity of the power system is more than 32GWe, which is more than 10 times capacity of any nuclear unit in the range of 1000 to 1700MWe, the system is vulnerable to extreme voltage variations, especially voltage degradation during peak load conditions. These conditions can lead to voltage collapse if a counter measure, usually load shedding, is not taken in a proper time. Hence, it is necessary to analyze the effect of such conditions on the safe and economic operation of the NPP. In this paper we analyzed the effects of grid voltage degradation on the safe and economic operation of the Advanced Power Reactor (APR1400) to determine any adverse effects on the plant auxiliary loads while operating in the Egyptian power system. In this paper the effects of grid voltage degradation on the safe and economic operation of APR1400 were investigated taking into account, generator operating limits, plant safety requirements, operation modes and loading categories in order to determine any adverse effect on the plant auxiliary loads while operating in the Egyptian power system. The results of the load flow and motor starting analysis demonstrated that during normal operation the automatic voltage regulator and transformers OLTCs can mitigate the effect of grid voltage degradation without any detrimental effect on the plant auxiliary loads. During the highly unlikely LOCA condition if the grid voltage degraded below 95%, the degraded voltage relays at Class 1E 4.16 kV buses will trip the supply and load breakers and reconnect the required safety loads to the EDG after 4 minutes time delay. During this period the safety loads required for LOCA can be started and accelerated to their rated speed safely even in the worst case of expected degraded voltage

A Study on the Coupled FEM-Analysis for Reactor Vessel Lower Head of APR1400 under the Severe Accident Scenario

Energy Technology Data Exchange (ETDEWEB)

Kim, Hyonam; Namgung, Ihn [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2014-10-15

For the stabilization of the RPV the in-vessel retention strategy with external reactor vessel cooling (IVR-ERVC) is adopted in APR1400. Under this severe accident condition, a good understanding of the mechanical behavior of the reactor vessel lower head (RVLH) is necessary both for verification of structural integrity and for improving the design applying appropriate accident mitigation strategies. The purpose of this study is to develop the analysis method of the RVLH with thermo-mechanical analysis using FEM tool (ANSYS v.15) in case of core-melting severe accident condition, and then analyze the RVLH of APR1400 including creep behavior. The plastic strain can be the major cause of lower head failure on the reactor vessel, and the creep cannot be not negligible factor of the failure under the severe accident condition. In the study, we applied constant convection coefficient at assumed temperature on the outside wall of RPV and substitute creep data of SA-508. In addition, it was found that the steel ablation at the interface between corium and vessel steel is not only a thermal phenomenon in the METCOR experiments. Corrosion processes and the formation of eutectics lead to the erosion of the vessel steel at temperatures that are significantly lower than the melting temperature of steel. It called thermo-chemical attack of the corium (corrosion). Reduced wall thickness because of the thermo-chemical effect by corium increase the equivalent plastic strain, and decrease the minimum time to reach 20% creep strain.

Besoins perçus et adaptation des démarches d’enseignement: le cas de l’enseignement des sciences et technologies au secondaire

Directory of Open Access Journals (Sweden)

Jean-Claude Kalubi

2009-07-01

Full Text Available Cet article traite de l’adaptation des démarches d’enseignement en cours d’action, adoptées par les enseignants des sciences et technologies de l’école secondaire. Il vise à comprendre les processus dynamiques de l’adaptation de l’enseignement. Il s’appuie sur des données qui ont été obtenues grâce à un protocole de recherche qualitative axé sur des techniques de groupes de réflexion. Les résultats de la recherche mettent en évidence l’hétérogénéité des parcours d’adaptation des enseignants. Ils soulignent la nécessité du professionnalisme de l’enseignant des sciences et technologies. Ils suggèrent de prendre en considération la complexité des besoins d’adaptation. Ceux-ci commandent en définitive la compatibilité entre les démarches de l’enseignant et les besoins de ses élèves. Le processus d’adaptation est aussi guidé par le plaisir de la reconnaissance, les rapports de l’enseignant aux savoirs, de même que par la défense des valeurs collectives.Mots clé: adaptation de l’enseignement, perception des besoins, enseignement des sciences et technologies This article deals with the adjustment of teaching approaches made by high school science and technology teachers while teaching. It aims at achieving a better understanding of the dynamic processes of teaching adjustment. It relies on a qualitative methodology using focus groups. Data analysis shows the multiplicity of ways that teachers use to adjust their teaching. It stresses out the importance of science and technology teachers’ professionalism and suggests taking into account the complexity of teacher and student needs in the equation of teaching adjustment. Those needs call for an increased compatibility between teaching approaches and students’ needs. The adjustment of teaching approaches is also related to the quest for recognition, the teacher relationship with knowledge and the collective values in place

Evaluation on thermal-hydraulic characteristics for passive safety device of APR1400

Energy Technology Data Exchange (ETDEWEB)

Yoo, Seong Yeon; Lee, S. H.; Son, M. K. [Korea Association for Nuclear Technology, Taejon (Korea, Republic of); Jee, M. S.; Chung, M. H. [Chungnam National Univ., Taejon (Korea, Republic of)

2001-07-15

To establish evaluation and verification guideline for the APR1400, thermal-hydraulic characteristics for fuel rod bundle, reactor vessel and fluidic device is analyzed using FLUENT. Scope and major results of research are as follows : Thermal-hydraulic characteristics for nuclear fuel rod bundle: design data for nuclear fuel rod bundle and structure are surveyed, and 3 x 3 sub-channel model is adopted to investigate the fluid flow and heat transfer characteristics in fuel rod bundle. Computational results are compared with the heat transfer data measured by naphthalene sublimation method, and numerical analysis and evaluation are performed at various design conditions and flow conditions. Thermal-hydraulic characteristics for reactor vessel: reactor vessel design data are surveyed to develop numerical model. Porous media model is applied for fuel rod bundle, and full-scale, three dimensional simulation is performed at actual operating conditions. Distributions of velocity, pressure and temperature are discussed. Flow characteristics for fluidic device: three dimensional numerical model for fluidic device is developed, and numerical results are compared with experimental data obtained at KAERI in order to verify numerical simulation. In addition, variation of flow rate is investigated at various elapsed times after valve operating, and flow characteristics is analyzed at low and high flow rate conditions, respectively.

Modeling of melt retention in EU-APR1400 ex-vessel core catcher

Energy Technology Data Exchange (ETDEWEB)

Granovsky, V. S.; Sulatsky, A. A.; Khabensky, V. B.; Sulatskaya, M. B. [Alexandrov Research Inst. of Technology NITI, Sosnovy Bor (Russian Federation); Gusarov, V. V.; Almyashev, V. I.; Komlev, A. A. [Saint Petersburg State Technological Univ. SPbSTU, St.Petersburg (Russian Federation); Bechta, S. [KTH, Stockholm (Sweden); Kim, Y. S. [KHNP, 1312 Gil 70, Yuseongdaero, Yuseong-gu, Daejeon (Korea, Republic of); Park, R. J.; Kim, H. Y.; Song, J. H. [KAERI, 989 Gil 111, Daedeokdaero, Yuseong-gu, Daejeon (Korea, Republic of)

2012-07-01

A core catcher is adopted in the EU-APR1400 reactor design for management and mitigation of severe accidents with reactor core melting. The core catcher concept incorporates a number of engineering solutions used in the catcher designs of European EPR and Russian WER-1000 reactors, such as thin-layer corium spreading for better cooling, retention of the melt in a water-cooled steel vessel, and use of sacrificial material (SM) to control the melt properties. SM is one of the key elements of the catcher design and its performance is critical for melt retention efficiency. This SM consists of oxide components, but the core catcher also includes sacrificial steel which reacts with the metal melt of the molten corium to reduce its temperature. The paper describes the required properties of SM. The melt retention capability of the core catcher can be confirmed by modeling the heat fluxes to the catcher vessel to show that it will not fail. The fulfillment of this requirement is demonstrated on the example of LBLOCA severe accident. Thermal and physicochemical interactions between the oxide and metal melts, interactions of the melts with SM, sacrificial steel and vessel, core catcher external cooling by water and release of non-condensable gases are modeled. (authors)

Development of a Human Performance Evaluation Support System for Human Factors Validation of MCR MMI Design in APR-1400

International Nuclear Information System (INIS)

Ha, Jun Su; Seong, Poong Hyun

2005-01-01

As CRT-based display and advanced information technology were applied to advanced reactors such as APR-1400 (Advanced Power Reactor-1400), human operators' tasks became more cognitive works. As a results, Human Factors Engineering (HFE) became more important in designing the MCR (Main Control Room) MMI (Man-Machine Interface) of an advanced reactor. According to the Human Factors Engineering Program Review Model, human factors validation of MCR MMI design should be performed through performance-based tests to determine whether it acceptably supports safe operation of the plant. In order to support the evaluation of the performance, a HUman Performance Evaluation Support System (HUPESS) is in development

Application of the risk-informed methodology for APR1400 P-T limits curve

Energy Technology Data Exchange (ETDEWEB)

Kim, K.; Namgung, I. [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2014-07-01

A reactor pressure vessel (RPV) in a nuclear power plant has operational limits of pressure and temperature to prevent a potential drastic propagation of cracks due to brittle fracture. We call it a pressure-temperature limits curve (P-T limits curve). Appendix G of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code, Section XI, provides deterministic procedures to develop the P-T limits curve for the reactor pressure vessel. Recently, an alternative risk-informed methodology has been added in the ASME Code. Risk-informed means that we can consider insights from a probabilistic risk assessment by using this methodology. This alternative methodology provides a simple procedure to develop risk-informed P-T limits for heat up, cool down, and hydrostatic test events. The risk-informed P-T limits curve is known to provide more operational flexibility, particularly for reactor pressure vessels with relatively high irradiation levels and radiation sensitive materials. In this paper, we developed both the deterministic and a risk-informed P-T limits curve for an APR1400 reactor using Appendix G of the ASME Code, Section XI and compare the results in terms of additional operational margin. (author)

Angiomyolipome rénal agressif avec extension à la veine rénale: à propos d'un cas et une revue de la littérature

Science.gov (United States)

Majdoub, Aziz El; Khallouk, Abdelhak; Farih, Moulay Hassan

2017-01-01

L'angiomyolipome rénal est une tumeur qui est reconnue bénigne. Elle présente trois composantes différentes: musculaire, vasculaire et graisseuse, dont la distribution est variable. Le diagnostic repose sur la mise en évidence de la composante graisseuse intra-tumorale en TDM ou IRM. Exceptionnellement la tumeur peut avoir un caractère agressive avec extension locorégionale et veineuse (la veine rénale et la veine cave inferieure). Nous présentons une observation d'une patiente âgée de 37 ans présentant un Angiomyolipome rénal volumineux avec extension à la veine rénale. PMID:29599888

Lipoblastome de la fosse sous temporale

Science.gov (United States)

Najib, Jaafar; Aniba, Khalid; Laghmari, Mehdi; Lmejjati, Mohammed; Ghannane, Houssine; Benali, Said Ait; Ennadam, Hind; Mrabti, Hind; Idrissi, Nadia Cherif

2014-01-01

Le lipoblastome est une tumeur bénigne rare, formée d'adypocytes immatures associés à la présence d'une matrice myxoide, de septas fibreux, et d'une architecture lobulaire. Il survient généralement chez le nourrisson et l'enfant. Cette tumeur touche dans la majorité des cas les tissus sous-cutanés des extrémités et du tronc. Elle est extrèmement rare au niveau de la tète et du cou. Un total de moins de 100 cas a été rapporté précédemment dans la littérature. PMID:25918563

Conceptual design of passive containment cooling system with air holdup tanks of improved APR+

International Nuclear Information System (INIS)

Jeon, Byong Guk; Cheon No, Hee

2014-01-01

In Korea, after the successful validation of passive auxiliary feedwater system (PAFS), a passive containment cooling system (PCCS) gets attention for future development. We suggested PCCS design based on APR+, an advanced PWR developed in Korea, and performed scoping analysis. On the extension of the simple scoping analysis, MARS simulation is performed to incorporate the behavior of water pool outside the containment as well as steam-air mixture inside the containment. Through the simulation we demonstrated the effectiveness of the air holdup tank (AHT). Also we investigated the effect of the models of heat transfer coefficients between steam-air mixture side and water side, and flow instability inside HX tubes. The presence of AHT enables us to reduce the number of required HX tubes more than half through an increase in the heat transfer coefficients due to the reduction of air fraction in the containment. Finally flow instability was observed and mitigated by putting orifice plates at the inlet of tubes, increasing height of return nozzle, and increasing a tube angle. (authors)

Pharmacothérapie de la dépression chez les aînés

Science.gov (United States)

Frank, Christopher

2014-01-01

Résumé Objectif Discuter du traitement pharmacologique de la dépression chez les personnes âgées, y compris le choix des antidépresseurs, le titrage de la dose, la surveillance de la réponse et des effets secondaires et le traitement des cas réfractaires. Sources des données Les lignes directrices de 2006 de la Canadian Coalition for Seniors’ Mental Health sur l’évaluation et le traitement de la dépression ont servi comme source principale. Pour recenser les articles publiés après les lignes directrices, on a procédé à une recherche documentaire dans MEDLINE de 2007 à 2012 à l’aide des expressions en anglais depression, treatment, drug therapy et elderly. Message principal Le but du traitement devrait être la rémission des symptômes. L’amélioration des symptômes peut être surveillée en fonction des objectifs du patient qu’on a identifiés ou en se servant d’outils cliniques comme le Patient Health Questionnaire–9. On devrait envisager le traitement en 3 étapes: l’étape du traitement aigu pour obtenir la rémission des symptômes, une étape de continuation pour prévenir la récurrence d’un même épisode de la maladie (rechute) et une étape de maintien (prophylaxie) pour prévenir de futurs épisodes (récurrence). Le dosage initial devrait être la moitié de la dose de départ habituelle chez l’adulte et il devrait être titré régulièrement jusqu’à ce que le patient réponde, jusqu’à ce que la dose maximale soit atteinte ou encore que les effets secondaires en limitent l’augmentation. Parmi les effets secondaires fréquents, on peut mentionner les chutes, la nausée, les étourdissements, les céphalées et, moins communément, l’hyponatrémie et des changements dans l’intervalle QT. Des stratégies pour changer ou augmenter les antidépresseurs sont présentées. Les patients plus âgés devraient être traités pendant au moins un an à compter de l’observation d’une amélioration clinique et

The Development and Evaluation of Inherent RPCS for the APR1400

Energy Technology Data Exchange (ETDEWEB)

Choi, Jae D.; Ryu, Seok H.; Jung, Dong C.; Kim, Joon S.; Baek, Byung C.; Sung, Song K.; You, Guk J. [KNF, Daejeon (Korea, Republic of); Kim, Han G. [KHNP, Daejeon (Korea, Republic of); Chi, Sung G. [KOPEC, Daejeon (Korea, Republic of)

2008-10-15

The APR1400 RPCS (Reactor Power Cutback System) is designed to rapidly reduce the core power to eliminate the need for a reactor trip following a large load rejection or a loss of two main feedwater pumps at high power. GDC (General Design Criteria) 25 says 'Protection system requirements for reactivity control malfunctions. The protection system shall be designed to assure that SAFDL (Specified Acceptable Fuel Design Limits) are not exceeded for any single malfunction of the reactivity control systems, such as accidental withdrawal (not ejection or dropout) of control rods.' In order to comply GDC 25, CPCS (Core Protection Calculator System) will apply a big power penalty({approx} 1.3) to determine the minimum DNBR (Departure from Nucleate Boiling Ratio), the maximum LPD(Local Power Density) and reactor may immediately trip by CPCS low DNBR and high LPD during high power operation for 12-finger CEA drop. The purpose of this study is to develop the inherent RPCS to avoid unwanted reactor trips due to a 12-finger CEA drop. In order to accomplish this purpose, the CPCS should be modified to send RPCS actuation signal and not to apply power penalty due to 12-finger CEA drop for a shot period. During this period which is determined by assessment of safety, the SAFDL will not be violated without any CPCS trip function. The system and CPCS performance is evaluated to verify that CPCS trip does not occurred during 12-finger CEA drop event.

Comparison of serpent and triton generated FEW group constants for APR1400 nuclear reactor core

International Nuclear Information System (INIS)

Elsawi, Mohamed A.; Alnoamani, Zainab

2015-01-01

The accuracy of full-core reactor power calculations using diffusion codes is strongly dependent on the quality of the homogenized cross sections and other few-group constants generated by lattice codes. For many years, deterministic lattice codes have been used to generate these constants using different techniques: the discrete ordinates, collision probability or the method of characteristics, just to name a few. These codes, however, show some limitations, for example, on complex geometries or near heavy absorbers as in modern pressurized water reactor (PWR) designs like the Korean Advanced Power Reactor 1400 (APR1400) core. The use of continuous-energy Monte Carlo (MC) codes to produce nuclear constants can be seen as an attractive option when dealing with fuel or reactor types that lie beyond the capabilities of conventional deterministic lattice transport codes. In this paper, the few-group constants generated by two of the state-of-the-art reactor physics codes, SERPENT and SCALE/TRITON, will be critically studied and their reliability for being used in subsequent diffusion calculations will be evaluated. SERPENT is a 3D, continuous-energy, Monte Carlo reactor physics code which has a built-in burn-up calculation capability. It has been developed at the Technical Research Center of Finland (VTT) since 2004. SCALE/TRITON, on the other hand, is a control module developed within the framework of SCALE package that enables performing deterministic 2-D transport calculations on nuclear reactor core lattices. The approach followed in this paper is as follows. First, the few-group nuclear constants for the APR1400 reactor core were generated using SERPENT (version 2.1.22) and NEWT (in SCALE version 6.1.2) codes. For both codes, the critical spectrum, calculated using the B1 method, was used as a weighting function. Second, 2-D diffusion calculations were performed using the US NRC core simulator PARCS employing the two few-group constant sets generated in the first

Analysis of Hydrogen Concentration Distribution during an SBO Accident for Shin-Ulchin APR1400

Energy Technology Data Exchange (ETDEWEB)

Kim, Jongtae; Hong, Seong Wan [Korea Atomic energy Research Institute, Daejeon (Korea, Republic of)

2013-10-15

To prohibit the accumulation of hydrogen, the containment volume is considered to reduce the hydrogen concentration, or hydrogen mitigation devices such as PARs or igniters are installed in the containment. In the case of the Fukushima NPPs, the applied strategy for the hydrogen safety is the use of a containment venting system (CVS). In this way, the hydrogen accumulated in the containment vessel is vented into the environment. One of the causes of the hydrogen explosions occurring in the containment buildings of the Fukushima NPPs is expected to be the failure of the venting system. The hydrogen was therefore easily accumulated in the containment building. It is uncertain what the ignition source for the hydrogen combustion was during the accident. However, it is not too conservative to assume that an ignition source exists at any time and any place in a containment during a core-melt accident. Shin-Ulchin 1 and 2, which are construction plants of an APR 1400, are two of the newest NPPs in Korea. They have many features to enhance the safety margin during a design-based and beyond-design-based accident. One of them is the in-containment refueling water storage tank (IRWST) located inside the containment. It is used as a sink/source for feed-bleed operation. When the core is damaged along an accident progression, the hydrogen generated in the RPV can be released into the IRWST of the APR1400 with steam and water. From a previous study, it was found that a highly concentrated hydrogen/air mixture can be developed if the hydrogen is released into the IRWST. In the case of Shin-Ulchin 1 and 2, the hydrogen mitigation strategy during a high-pressure accident such as a station blackout (SBO) is changed by installing a 3-way valve. When a severe accident management (SAM) for the plant is initiated, the flow path from a pressurizer to the IRWST is changed into a steam-generator (S/G) compartment by turning the 3-wat valve actively (pilot operated). By doing so, it is

angiofibrome nasopharyngien compliqué d'un syndrome de foster ...

African Journals Online (AJOL)

FACIALE. * SERVICE DE RADIOTHÉRAPIE. HÔPITAL UNIVERSITAIRE F. HACHED - SOUSSE. RESUME. L'angiofibrome nasopharyngien (FNP) est une tumeur vasculaire bénigne localement agressive. Il représente 0,05% des.

Pembuatan "Primary Crown" pada Perawatan dengan Restorasi Jembatan Konvensional (Laporan Kasus Klinik

Directory of Open Access Journals (Sweden)

Suhandi Sidjaya

2015-10-01

Full Text Available Secondaire caries was considered as an important contributor to the complication in fixed prosthodontic (crown & bridgework. One factor that is improper cervical margin of the restoration could lead to desementation and further to secondair caries occurance. Tensile stress as leverage at long span bridge could open the cervical margin of the retainer. Metal coping as primary coping could protect the abutment teeth of long span bridge of this possibility. This article reported two cases treated with long span conventional bridge on primary metal coping at its abutment.

Les usages de la flexibilité temporelle chez les enseignantes du secondaire The uses of flexible time by female secondary-school teachers

Directory of Open Access Journals (Sweden)

Julie Jarty

2009-09-01

Full Text Available De par sa flexibilité temporelle, il existe une perception largement répandue selon laquelle la profession enseignante serait woman-friendly, « bien pour une femme ». Le « plafond de verre » est pourtant une réalité pour de nombreuses femmes au sein de l’enseignement du second degré. Centré sur une étude des perceptions et des pratiques temporelles au sein de ce groupe professionnel dans une perspective de genre, cet article s’appuie sur une analyse critique des discours de 40 entretiens individuels réalisés auprès d’hommes et de femmes enseignant-e-s du secondaire et de leurs « carnets-temps ». Il s’agit d’explorer la manière dont ils et elles utilisent leur temps et cette flexibilité professionnelle. Le résultat de cette recherche permet de montrer que les expériences temporelles sexuées sont particulièrement prédominantes, ce qui contribue à expliquer les difficultés des femmes enseignantes à accéder aux positions les plus prestigieuses et les mieux rémunérées de la hiérarchie. Néanmoins, la mobilisation d’une typologie des expériences temporelles des enseignantes nous conduit à identifier l’existence de discours alternatifs, reconnaissant ainsi les contrastes du degré selon lequel les rapports sociaux de sexe sont reproduits, reconfigurés ou transformés au sein de la profession.Because of its temporal flexibility, there is a widespread notion that the teaching profession is ‘woman-friendly’ or “good for women”. However, there is extensive evidence that a ‘glass ceiling’ exists for female secondary school teachers too. Based on a study of temporal perceptions and practices within the teaching profession in a gendered perspective, this paper draws on the critical discourse analysis of forty individual interviews conducted with male and female secondary school teachers and of their schedules. The aim was to examine the use they make of their time and professional flexibility

Tumeurs mandibulaires : Aspects epidemiologiques et ...

African Journals Online (AJOL)

Objectives: Study the anatomopathological and epidemiological aspects of the tumors of the mandible in order to compare the literature data. Methodology: It is an analytic, descriptive and retrospective study conducted over a period of 10 years at the ENT and the Anatomo-pathology Departments of CHU in Lomé. Results: ...

WAJM 28 (5).pmd

African Journals Online (AJOL)

user

Toucher rectal pour les tumeurs de la prostate et du rectum: Connaissance et ... PSA, Prostate Specific Antigen; RTA, Rectal Teaching Associate; SPETA, ... ability to diagnose prostatic and rectal ..... have felt benign prostate between one.

Drop size measurements and entrainment in APR1400 during LBLOCA reflood phase

Energy Technology Data Exchange (ETDEWEB)

Lee, Eo Hwak

2010-02-15

A study has been performed to investigate droplet size in the nuclear reactor of APR1400 during LBLOCA reflood phase and to develop droplet entrainment and deposition models for SPACE (Safety and Performance CodE) which is a safety analysis tool for PWR being developed in Korea. A freezing technique for measuring the size of droplets was developed to obtain the droplet size distribution in horizontal annular flow in a pipe with a 37.1 mm diameter. Droplets are frozen by using an extremely low temperature nitrogen gas with liquid film extraction. They are then photographed with a microscope and a CCD camera and measured by means of an image process. The results are compared with various experimental data. The droplet sizes measured by the freezing technique are comparable with those measured by other methods at a high superficial air velocity (of 50 m/s). However, because of the film extraction problem, the droplet sizes measured at a low superficial air velocity of less than 40 m/s are higher than those measured by other methods. A present method suggested for predicting the Sauter mean diameter is based on the maximum droplet size correlation for the experimental data, with and without liquid film extraction. The average droplet size is remarkably smaller downstream of the liquid film extractor because large droplets from the liquid film are excluded. In order to understand and to predict a heat transfer between superheated steam and droplets properly during reflood phase of LBLOCA, it is very important to measure broken droplet sizes by spacer grids. A study, therefore, has been performed to investigate droplet size in rod bundles with spacer grids and to develop a spacer grid droplet breakup model for safety analysis codes. Experiments were conducted with liquid droplets (SMD of 300∼700 μm) and various spacer grids at superficial air velocity of 10 m/s and 20 m/s based on FLECHT SEASET. The test channel and the grids were heated to 150 .deg. C to prevent

Drop size measurements and entrainment in APR1400 during LBLOCA reflood phase

International Nuclear Information System (INIS)

Lee, Eo Hwak

2010-02-01

A study has been performed to investigate droplet size in the nuclear reactor of APR1400 during LBLOCA reflood phase and to develop droplet entrainment and deposition models for SPACE (Safety and Performance CodE) which is a safety analysis tool for PWR being developed in Korea. A freezing technique for measuring the size of droplets was developed to obtain the droplet size distribution in horizontal annular flow in a pipe with a 37.1 mm diameter. Droplets are frozen by using an extremely low temperature nitrogen gas with liquid film extraction. They are then photographed with a microscope and a CCD camera and measured by means of an image process. The results are compared with various experimental data. The droplet sizes measured by the freezing technique are comparable with those measured by other methods at a high superficial air velocity (of 50 m/s). However, because of the film extraction problem, the droplet sizes measured at a low superficial air velocity of less than 40 m/s are higher than those measured by other methods. A present method suggested for predicting the Sauter mean diameter is based on the maximum droplet size correlation for the experimental data, with and without liquid film extraction. The average droplet size is remarkably smaller downstream of the liquid film extractor because large droplets from the liquid film are excluded. In order to understand and to predict a heat transfer between superheated steam and droplets properly during reflood phase of LBLOCA, it is very important to measure broken droplet sizes by spacer grids. A study, therefore, has been performed to investigate droplet size in rod bundles with spacer grids and to develop a spacer grid droplet breakup model for safety analysis codes. Experiments were conducted with liquid droplets (SMD of 300∼700 μm) and various spacer grids at superficial air velocity of 10 m/s and 20 m/s based on FLECHT SEASET. The test channel and the grids were heated to 150 .deg. C to prevent

Scanning Techniques for Brain-Tumour, Localization; Techniques Scintigraphies pour la Iocalisation des Tumeurs Cerebrales; Tekhnika skennirovaniya pri opredelenii lokalizatsii opukholej mozga; Tecnicas Centelleograficas para la Localizacion de Tumores Cerebrales

Energy Technology Data Exchange (ETDEWEB)

Duggan, M. H.; Brice, J.; Jones, E.; Mallard, J. R.; Myers, M. L. [Department Of Medical Physics, Postgraduate Medical School, Hammersmith Hospital, London (United Kingdom)

1964-10-15

may then be compared with this pattern. Such analysis lends itself to computer techniques. The use of continuous averaging techniques may also prove to be of value in improving the perception of abnormalities near the limits of detection in moving detector systems. The possible use of multichannel analysers to apply this and at the same time make possible a valuable new display system for both moving and stationary systems is presented. (author) [French] On a utilise l'appareil de gammagraphie en couleurs pour la scintigraphie de deux series cliniques de tumeurs cerebrales, dans le premier cas au moyen de {sup 74}As (detection des positons), dans le deuxieme cas au moyen de l'albumine marquee avec {sup 131}I (detection des rayons gamma, avec un collimateur a focalisation). L'auteur compare les resultats obtenus dans les deux series. Matthews a montre, dans des etudes sur des rats ayant des tumeurs, que le citrate de {sup 206}Bi devrait etre un materiau particulierement favorable pour la localisation des tumeurs cerebrales; aussi fait-on actuellement une troisieme serie clinique avec ce produit (detection des rayons gamma, avec un collimateur a focalisation). L'auteur presente les resultats preliminaires de cette etude. Les collimateurs a focalisation utilises pour les emetteurs gamma ont un foyer geometrique profond et donnent, pour des sources ponctuelles, des courbes d'isoreponse qui sont presque independantes de la profondeur sur une distance de 20 cm. Les resultats des experiences faites avec une serie de collimateurs ont fourni les donnees necessaires a la realisation de collimateurs de ce genre destines a des fins determinees. Des tumeurs du cerveau ont ete explorees avec un detecteur stationnaire, en ayant recours a la photographie gamma et a l'enregistrement par un oscilloscope a memoire. Les avantages de ce procede resident dans une plus grande sensibilite et une visualisation plus rapide de la repartition de la radioactivite, ce qui permet de proceder a des

Case report

African Journals Online (AJOL)

abp

31 juil. 2013 ... Key words: Métastase mammaire, cancer gastrique, diagnostic, grossesse. Received: .... Cliniquement, il s'agit d'une tumeur palpable, localisée .... diagnosis with primary breast signet ring cell carcinoma. Journal of ...

Pan African Medical Journal - Vol 22, No 1 (2015)

African Journals Online (AJOL)

Tumeur pseudopapillaire et solide du pancréas: une cause rare de masse abdominale ... Nontyphoidal Salmonella Septic arthritis of the elbow in a healthy infant ...... Hypoglycemia revealing arachnoidocele in infant · EMAIL FREE FULL TEXT ...

Two-phase flow parameters of a downcomer boiling during a postulated reflood phase of APR1400; Parametres d'ecoulement diphasique dans un ebullition a la cuve en acier pendant un refroidissement d'un APRP de APR1400

Energy Technology Data Exchange (ETDEWEB)

Byong-Jo, Yun; Dong-Jin, Euh; Chul-Hwa, Song [Korea Atomic Energy Research Inst. (Korea, Republic of)

2009-07-01

Downcomer boiling phenomena is one of the key issues for a postulated large-break LOCA (LBLOCA) in a conventional pressurized water reactor, because it can degrade the hydraulic head of the coolant in the downcomer and consequently affect the reflood flow rate for a core cooling. To investigate the thermal hydraulic behavior in the downcomer region of the APR1400, a test program for a downcomer boiling is being progressed for the reflood phase of a postulated LBLOCA. Test was performed in a one side heated rectangular test channel which was designed by adopting a full-pressure, full-height, and full-size downcomer-gap approach, but with the circumferential length was reduced 47.08-fold. The test consists of two steps: (I) for the global two-phase flow parameters and (II) for the local two-phase flow parameters. The step-I test has already been completed. In the present paper, the experimental results of the step-II test are introduced. (authors)

Etude paramétrique des effets de la stratification de la flamme sur les émissions d'oxydes d'azote (première partie Parametric Study of Statification Effects on Nitric Oxyde Emissions from Flam (Part One

Directory of Open Access Journals (Sweden)

De Soete G.

2006-11-01

Full Text Available On a étudié les effets de la stratification de flammes de prémélange laminaires, stationnaires et non stationnaires, sur les émissions d'oxydes d'azote formés par le mécanisme thermique et par le mécanisme du fuel-NO. Deux modalités de stratification ont été considérées, l'une juxtaposant sur le même plan les zones de combustion primaires correspond aux fractions individuelles du mélange stratifié (stratification en juxtaposition, l'autre disposant ces zones de combustion primaires sur des plans successifs (stratification en succession. Les émissions d'oxydes d'azote mesurées sur les flammes stratifiées ont été comparées à celles provenant de flammes non stratifiées de même composition globale et brûlant dans des conditions identiques. L'étude montre qu'il y a lieu de distinguer deux types d'effets de stratification. II existe un effet primaire -qui est la simple conséquence du morcellement de la flamme en un certain nombre de zones de combustion primaires (caractérisées par des compositions différentes et qui se traduit par l'additivité des émissions individuelles provenant des fractions respectives du mélange. L'effet total de la stratification se réduit à ce seul effet primaire au cas où les vitesses de formation des oxydes d'azote deviennent nulles après re-mélange des produits de combustion provenant des différentes fractions du mélange stratifié. Il en est ainsi par exemple dans le cas des flammes non stationnaires stratifiées en succession ; il en résulte alors soit une augmentation soit une diminution des émissions d'oxydes d'azote par rapport à celles des flammes non stratifiées, suivant la valeur de la richesse globale et du degré de stratification. Des effets secondaires de stratification se manifestent chaque fois que des produits de combustion, provenant d'une zone de combustion primaire donnée, sont introduits totalement ou partiellement dans un autre front de flamme créé par la

Consolidation and Decomposition of APR1400 NRC Design Certification Processes for Collaborative and Accelerated Processing

Energy Technology Data Exchange (ETDEWEB)

Cho, Young Chul [FNC Technology Co., Yongin (Korea, Republic of); Kang, Deog Ji [KNHP, Daejeon (Korea, Republic of)

2016-05-15

KEPCO and KHNP are conducting APR1400 Design Certification from NRC. For the proper management of processes and information, a system called RIS (Regulatory Information management System) has been implemented by FNC from 2014, and it is on the final stage. In retaining the certification from NRC, RIS will be a very essential role by providing platform for collaborative and accelerated processing of responses to RAI (Request of Additional Information). Preparation of responses to RAI with this kind of systematic approach may be the first in the world. Westinghouse is doing manually and using MS Excel to collect the processing status. Where as, RIS will enable each member can do his own job and collect the status automatically. In this paper, how collaborative and accelerated processing of responses to RAI can be enabled will be described, and further enhancements will also be discussed. It handles MS Word directory with the help of VSTO. And with the help of Aspose.Total for .NET, the prepared response to RAI meets NRC's requirements. Through some further work and direct integration with requirement management solution, RIS can be expanded to cover a prior impact notice in case of DCD being altered.

Preliminary COM3D Analysis for H{sub 2} Combustion in the APR1400 Containment

Energy Technology Data Exchange (ETDEWEB)

Kang, Hyung Seok; Kim, Jongtae; Kim, Sang-Baik; Hong, Seong-Wan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-10-15

In order to assure the containment integrity of APR1400, it is necessary to evaluate an overpressure buildup resulting from a propagation of hydrogen flame along the structure and wall in the containment during a severe accident using the COM3D. Korea Atomic Energy Research Institute (KAERI) established a numerical analysis system for evaluating an overpressure buildup owing to a hydrogen combustion in the containment of a nuclear power plant by importing COM3D from KIT in Germany. The COM3D has been currently used in the simulations of the combustions and explosions, together with the system of industrial risk mitigation of hydrogen and burnable gases in nuclear containment and auxiliary buildings. KAERI performed the hydrogen combustion analysis using the COM3D code with the initial hydrogen distribution calculated by the GASFLOW under assumption of 85% metal-water reaction in the reactor vessel. From the COM3D results, we can know that the pressure buildup was about 100 kPa because the flame speed was not increased above 1000 m/s and the pressure wave passed through the open spaces in the large containment.

Steady state flow evaluations for passive auxiliary feedwater system of APR

International Nuclear Information System (INIS)

Park, Jongha; Kim, Jaeyul; Seong, Hoje; Kang, Kyoungho

2012-01-01

This paper briefly introduces a methodology to evaluate steady state flow of APR+ Passive Auxiliary Feedwater System (PAFS). The PAFS is being developed as a safety grade passive system to completely replace the existing active Auxiliary Feedwater System (AFWS). Natural circulation cooling can be generally classified into the single-phase, two-phase, and boiling-condensation modes. The PAF is designed to be operated in a boiling-condensation natural circulation mode. The steady-state flow rate should be equal to the steady-state boiling/condensation rate determined by the steady-state energy and momentum balances in the PAFS. The determined steady-state flow rate can be used in the design optimization for the natural circulation loop of the PAFS through the steady-state momentum balance. Since the retarding force, which is to be balanced by the driving force in the natural circulation system design depends on the reliable evaluation of the success of a natural circulation system design depends on the reliable evaluation of the pressure loss coefficients. In PAFS, the core decay heat is released by natural circulation flow between the S G secondary side and the Passive Condensation Heat Exchanger (PCHX) that is immersed in the Passive Condensation Cooling Tank (PCCT). The PCCT is located on the top of Auxiliary building The driving force is determined by the difference between the S/G (heat Source) secondary water level and condensation liquid (heat sink) level. It will overcome retarding force at flowrate in the system, which is determined by vaporization and condensation of the steam which is generated at the S/G by the latent heat in system. In this study, the theoretical method to estimate the steady state flow rate in boiling-condensation natural circulation system is developed and compared with test results

sarcome d'ewing

African Journals Online (AJOL)

7 mai 2012 ... Le sarcome d'Ewing est une tumeur osseuse rare corres- pondant à la ... Introduction : petrous Ewing sarcoma is exceptional. We report a ..... (15) Iriz A, Albayrak L, Eryilmaz A. Extraskeletal primary Ewing's sarcoma of the.

Study of the secondary electron emission during bombardment of metal targets by positive D{sup +} and D{sub 2}{sup +} ions (1960); Etude de l'emission secondaire d'electrons au cours du bombardement de cibles metalliques par des ions positifs D{sup +} et D{sub 2}{sup +} (1960)

Energy Technology Data Exchange (ETDEWEB)

Leroy, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Prelec, K [Institut Rudjer Boskovic, Zagreb (Croatia)

1960-07-01

The secondary electron yield {gamma}-bar due to primary positive ions D{sup +} and D{sup +}{sub 2} has been measured in the 70 keV to 300 keV ion energy range. Several metallic targets have been used. The variation of this yield with the angle of incidence is proportional to sec {theta} where {theta} is the angle between the beam of primary ions and the normal to the target surface. The values {gamma}-bar decrease for increasing energy ions. At a given energy all the targets tried gave approximately the same electron yield. (author) [French] Le facteur d'emission secondaire a ete mesure pour des ions positifs D{sup +} et D{sup +}{sub 2} ayant une energie comprise entre 70 keV et 300 keV, sur differentes cibles metalliques. La variation de ce facteur avec l'angle d'incidence suit une loi de la forme {gamma}{sub 0} sec {theta}, {theta} etant l'angle entre le faisceau et la normale a la cible. Les valeurs de {gamma}-bar trouvees decroissent lorsque l'energie des ions incidents augmente, mais sont assez voisines les unes des autres, a une energie donnee, pour les differentes cibles essayees. (auteur)

Radiation protection measurements at Paks and its surroundings after the accident of the Chernobylsk nuclear power plant from 28 Apr 1986

International Nuclear Information System (INIS)

German, Endre; Kemenes, Laszlo; Rosa, Geza; Szabo, I.C.; Ormai, Peter; Ronaky, Jozsef; Divos, Ferenc; Varju, Bela; Horvath, Etelka.

1986-08-01

Experimental data on the contaminantion measured within a radius of 30 km from the Paks Nuclear Power Plant due to the accident of the Chernobylsk-4 reactor are given for the period between 28 Apr and 13 Jun 1986. Measurements on airborne and fallout activities, surface contamination of the ground, dose rates of γ radiation, activity concentration of the Danube, of milk, plant and food samples and the activity of human thyroid gland were carried out in the environmental control lab of the Paks NPP. According to the preliminary dose calculations the increment of the radiation exposure of the population is regarded to mount up to the average dose burden for half a year due to natural environmental radiation. (V.N.)

The Biological Effect of Fast Neutrons and High-Energy Protons; Effets Biologiques des Neutrons Rapides et des Protons de Haute Energie; Biologicheskoe dejstvie bystrykh nejtronov i protonov vysokikh ehnergii; Efectos Biologicos de los Neutrones Rapidos y de los Protones de Elevada Energia

Energy Technology Data Exchange (ETDEWEB)

Moskalev, Ju. I.; Petrovich, I. K.; Strel' cova, V. N.

1964-03-15

tumour of the thyroid gland also appear. With proton irradiation, the minimum tumour dose for haemopoietic tissue and the thyroid gland is in the neighbourhood of 250 rad, for the testicles 300 rad, for the prostate, the pancreas and the subcutaneous tissue 100 rad. After irradiation with fast neutrons the incidence of tumours of the testicles, the large intestine, the kidneys and the liver is increased at doses between 42.5 and 85 rad. The same is true for tumours of the skin and the subcutaneous tissue at a dose of 85 rad. With fast neutron irradiation tumours appeared at approximately three to five times lower radiation doses than with proton irradiation. (author) [French] Le memoire expose les resultats d'experiences visant a comparer l'e ffe t des neutrons rapides et celui des protons de haute energie (500 MeV) sur la duree de vie, le sang peripherique, la frequence et la rapidite d'apparition des tumeurs chez le rat, en tenant compte de la dose efficace et du delai d'observation. Les travaux ont porte sur 573 rats blancs pour les neutrons et sur 490 rats blancs pour les protons. Les animaux etaient exposes a des doses de neutrons rapides de 8,5 a 510 rad et a des doses de protons de 28 a 1008 rad. Pour les neutrons rapides et les protons, les auteurs ont determine les valeurs des doses effectives aiguees, sub-aiguees et chroniques. La DL{sup 30}{sub 50} est de 408 rad pour les neutrons et de 600 rad pour les protons; la DL{sup 120}{sub 50} s'eleve a 380 et 600 rad, respectivement. On a procede a une etude critique des lois qui regissent la mortalite des rats a breve echeance et apres des delais prolonges. D'apres les constatations, la survie moyenne des rats irradies par des neutrons rapides est independante de leur sexe. En ce qui concerne les differents indices du sang peripherique, la forme de la courbe dose/effet depend dans une forte mesure, non seulement de la radiosensibilite des cellules correspondantes du sang, mais aussi de la duree d'observation. Elle

WAJM 29(6) final corr.pmd

African Journals Online (AJOL)

user1

cell carcinoma; THCN, Thyroid Hürthle cell neoplasm. Hürthle Cell Neoplasms of Thyroid in South-Western Region of Saudi Arabia. Tumeurs A Cellules De Hürthle De La .... Organisation (WHO) as a subtype of follicular derived neoplasms.9 ...

Quelques conséquences de l'introduction de deux espèces de macrophytes, Elodea canadensis Michaux et Elodea nuttallii St. John, dans les écosystèmes aquatiques continentaux : exemple de la plaine d'Alsace et des Vosges du Nord (Nord-Est de la France

Directory of Open Access Journals (Sweden)

THIEBAUT G.

1997-01-01

Full Text Available L'introduction au XIXème et XXème siècle, de deux espèces d'élodées Elodea canadensis Michaux et Elodea nuttallii St. John, dans les cours d'eau du nord-est de la France, a induit des modifications dans la composition floristique et le fonctionnement des écosystèmes aquatiques. L'analyse comparative de la distribution géographique de ces deux hydrophytes dans les eaux calcaires (plaine d'Alsace et acides (Vosges du Nord a permis de préciser leur écologie. Après des phases successives d'expansion des deux espèces, celles-ci se sont intégrées dans les phytocénoses aquatiques. L'introduction dans les écosystèmes aquatiques d'Elodea canadensis et d'E. nuttallii a induit des phénomènes de compétition interspécifique, en faveur essentiellement d'Elodea nuttallii. Cette dernière apparaît comme l'espèce la plus compétitive dans les cours d'eau eutrophes de la plaine d'Alsace (aptitude à accumuler le phosphore, sensibilité moindre à l'azote ammoniacal. Les élodées peuvent réaliser une épuration biologique, mais provoquent, lors de leur décomposition, une eutrophisation secondaire des eaux en absence de faucardage.

African Journal of Neurological Sciences 2010 - Vol. 29, No 2 http ...

African Journals Online (AJOL)

29, No 2 http://ajns.paans.org. 3. CLINICAL STUDIES / ETUDE CLINIQUES. CONTRIBUTION DE LA BIOPSIE STEREOTAXIQUE DANS LA PRISE EN CHARGE DES TUMEURS. CEREBRALES: A PROPOS DE 283 CAS. CONTRIBUTION OF STEREOTAXIC BIOPSY IN THE MANAGEMENT OF BRAIN TUMORS: A PROPOS.

Cibler les cellules sénescentes dans le cancer du pancréas | IDRC ...

International Development Research Centre (IDRC) Digital Library (Canada)

causant les tumeurs) qui vise à interrompre l'expansion des cellules ayant un potentiel de malignité. Elle le fait en interrompant la prolifération ... IDRC and DHSC partner to fight antimicrobial resistance in animals. IDRC and the United Kingdom's ...

Case report

African Journals Online (AJOL)

abp

18 févr. 2013 ... pathologie, Hôpital Militaire Avicenne, Marrakech, Maroc. &Corresponding author: Bouchentouf Rachid, Service de pneumologie, Hôpital Militaire Avicenne, Marrakech, Maroc. Key words: Tumeur, Mélanome malin, métastases endobronchiques. Received: 20/09/2011 - Accepted: 18/10/2012 - Published: ...

Detailed evaluation of two phase natural circulation flow in the cooling channel of the ex-vessel core catcher for EU-APR1400

Energy Technology Data Exchange (ETDEWEB)

Park, Rae-Joon, E-mail: rjpark@kaeri.re.kr; Ha, Kwang-Soon; Rhee, Bo-Wook; Kim, Hwan Yeol

2016-03-15

Highlights: • Ex-vessel core catcher of PECS is installed in EU-APR1400. • CE-PECS has been conducted to test a cooling capability of the PECS. • Two phase flow in CE-PECS and PECS was analyzed using RELAP5/MOD3. • RELAP5 results are very similar to the CE-PECS data. • The super-step design is suitable for steam injection into the downcomer in PECS. - Abstract: The ex-vessel core catcher of the PECS (Passive Ex-vessel corium retaining and Cooling System) is installed to retain and cool down the corium in the reactor cavity of the EU (European Union)-APR (Advanced Power Reactor) 1400. A verification experiment on the cooling capability of the PECS has been conducted in the CE (Cooling Experiment)-PECS. Simulations of a two-phase natural circulation flow using the RELAP5/MOD3 computer code in the CE-PECS and PECS have been conducted to predict the two-phase flow characteristics, to determine the natural circulation mass flow rate in the cooling channel, and to evaluate the scaling in the experimental design of the CE-PECS. Particularly from a comparative study of the prototype PECS and the scaled test facility of the CE-PECS, the orifice loss coefficient in the CE-PECS was found to be 6 to maintain the coolant circulation mass flux, which is approximately 273.1 kg/m{sup 2} s. The RELAP5 results on the coolant circulation mass flow rate are very similar to the CE-PECS experimental results. An increase in the coolant injection temperature and the heat flux lead to an increase in the coolant circulation mass flow rate. In the base case simulation, a lot of vapor was injected into the downcomer, which leads to an instability of the two-phase natural circulation flow. A super-step design at a downcomer inlet is suitable to prevent vapor injection into the downcomer piping.

Detailed evaluation of two phase natural circulation flow in the cooling channel of the ex-vessel core catcher for EU-APR1400

International Nuclear Information System (INIS)

Park, Rae-Joon; Ha, Kwang-Soon; Rhee, Bo-Wook; Kim, Hwan Yeol

2016-01-01

Highlights: • Ex-vessel core catcher of PECS is installed in EU-APR1400. • CE-PECS has been conducted to test a cooling capability of the PECS. • Two phase flow in CE-PECS and PECS was analyzed using RELAP5/MOD3. • RELAP5 results are very similar to the CE-PECS data. • The super-step design is suitable for steam injection into the downcomer in PECS. - Abstract: The ex-vessel core catcher of the PECS (Passive Ex-vessel corium retaining and Cooling System) is installed to retain and cool down the corium in the reactor cavity of the EU (European Union)-APR (Advanced Power Reactor) 1400. A verification experiment on the cooling capability of the PECS has been conducted in the CE (Cooling Experiment)-PECS. Simulations of a two-phase natural circulation flow using the RELAP5/MOD3 computer code in the CE-PECS and PECS have been conducted to predict the two-phase flow characteristics, to determine the natural circulation mass flow rate in the cooling channel, and to evaluate the scaling in the experimental design of the CE-PECS. Particularly from a comparative study of the prototype PECS and the scaled test facility of the CE-PECS, the orifice loss coefficient in the CE-PECS was found to be 6 to maintain the coolant circulation mass flux, which is approximately 273.1 kg/m"2 s. The RELAP5 results on the coolant circulation mass flow rate are very similar to the CE-PECS experimental results. An increase in the coolant injection temperature and the heat flux lead to an increase in the coolant circulation mass flow rate. In the base case simulation, a lot of vapor was injected into the downcomer, which leads to an instability of the two-phase natural circulation flow. A super-step design at a downcomer inlet is suitable to prevent vapor injection into the downcomer piping.

Experience with a New Colour-Scintillographic Method for Diagnosing Liver Tumours and Inflammatory Liver Disorders; Experience d'une Nouvelle Methode d'Enregistrement Scintigraphique en Couleurs, pour le Diagnostic des Tumeurs Hepatiques et des Affections Inflammatoires du Foie; Opyt ispol'zovaniya novogo metoda tsvetnoj'' stsintigrafii dlya diagnostiki pechenochnykh opukholej i vospalitel'nykh protsessov pecheni; Ensayo de un Nuevo Metodo de Registro Centelleografico Policromo, para el Diagnostico de Tumores Hepaticos y de Inflamaciones del Higado

Energy Technology Data Exchange (ETDEWEB)

Sparchez, T.; Gheorghescu, B.; Steclaci, A.; Merculiev, E.; Popovici, M. [Clinique Medicale, Bucarest (Romania)

1964-10-15

que le noir represente l'activite maximum, situee au centre du foie ou le parenchyme est plus epais. Les couleurs intermediaires correspondent aux differentes zones d'isoradioactivite. Les auteurs ont etudie, a l'aide de cette methode, 150 cas de tumeurs hepatiques malignes (primitives et secondaires) et de tumeurs benignes, 80 cas d'hepatite chronique et de cirrhose et 50 cas normaux. Dans la majorite descas, ils ont utilise l'or-198 colloiedal (Amersham-Angleterre) injecte par voie intraveineuse. Ils ont effectue parallelement, dans un grand nombre de cas, des mecanogrammes, photoscintigrammes en blanc et noir et scintigrammes en couleurs. Le diagnostic a ete verifie par ponction, laparoscopie, laparophoto ou cinematographie, ponction biopsique, intervention chirurgicale ou necropsie. La methode scintigraphique en couleurs permet de mieux distinguer les variations d'intensite de la radioactivite, c'est-a-dire la desorganisation ou la substitution du parenchyme hepatique par processus tumoraux. (author) [Spanish] Para obtener imagenes que reflejasen mejor los detalles de la estructura del parenquima hepatico modificado por la enfermedad, los autores adaptaron al aparato Scanner-Tracerlab un dispositivo gracias al cual se pueden obtener diagramas hepaticos en siete colores. Cada color, elegido arbitrariamente, corresponde a un numero dado de impulsos y representa zonas de isorradiactividad, es decir, de tejido hepatico de volumen relativamente igual. En el centelleograma policromo, el blanco representa la radiactividad de fondo, mientras que el negro representa la actividad maxima, situada en el centro del higado, donde el parenquima es mas espeso. Los colores intermedios corresponden a las diferentes zonas de isorradiactividad. Recurriendo a este metodo, los autores estudiaron 150 casos de tumores hepaticos malignos (primitivos y secundarios) y de tumores benignos, 80 casos de hepatitis cronica y de cirrosis, y 50 casos normales. En la mayoria de los casos utilizaron

The LasB Elastase of Pseudomonas aeruginosa Acts in Concert with Alkaline Protease AprA To Prevent Flagellin-Mediated Immune Recognition.

Science.gov (United States)

Casilag, Fiordiligie; Lorenz, Anne; Krueger, Jonas; Klawonn, Frank; Weiss, Siegfried; Häussler, Susanne

2016-01-01

The opportunistic pathogen Pseudomonas aeruginosa is capable of establishing severe and persistent infections in various eukaryotic hosts. It encodes a wide array of virulence factors and employs several strategies to evade immune detection. In the present study, we screened the Harvard Medical School transposon mutant library of P. aeruginosa PA14 for bacterial factors that modulate interleukin-8 responses in A549 human airway epithelial cells. We found that in addition to the previously identified alkaline protease AprA, the elastase LasB is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition. Our results indicate that the production of two proteases with anti-flagellin activity provides a failsafe mechanism for P. aeruginosa to ensure the maintenance of protease-dependent immune-modulating functions. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Japānas un Amerikas Savienoto Valstu kauja par Okinavu 1945. gada: 1.aprīlis – 22. jūnijs

OpenAIRE

Leimanis, Normunds

2017-01-01

Bakalaura darba tēmas nosaukums ir „Japānas un Amerikas Savienoto Valstu kauja par Okinavu 1945. gada: 1. aprīlis – 22. jūnijs ”. Tā ir viena no lielākajām un asiņainākajām kaujām, kura notika Otrā Pasaules kara laika beigās. Tā bija viena no pēdējām kaujām Otrā Pasaules kara laikā. Kaujā par Okinavu piedalijās amerikāņu un japāņu karaspēki, kas cīnījās par savu valsti un tās godu. Galvenie Okinavas kaujas dalībnieki bija japāņu 32. armija un amerikāņu 10.armija. Galvenais atbildīgais par ...

Development of Alarm System link Drawing for Operation Support for APR1400 Digital Main Control Room

Energy Technology Data Exchange (ETDEWEB)

Kim, Ki-Hwan [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

Digitalized MMI(Man-Machine Interface) including Digital Main Control Room(MCR) and digital I and C system was being applied for SKN 3 and 4 Nuclear Power Plant(NPP) and subsequent APR1400 NPP type. But, operators can not easily find instrument for alarm immediately. Therefore, Alarm system is required to easily find instrument for Alarm. For this implementation, we will plan system design considering design feature without affecting network load and CPU load. We have developed Alarm system link drawing for digital MCR. Operators of the digitalized MCR navigates from their consoles to the drawings related to the plant alarms and their instruments or the operation status. Such method gives cognitive load to the operators having to travel to different locations in finding the related information. Screen Sharing System, which is the fundamental technique for Drawing Interconnection Alarm System is close to completion, and it should be functionally tested and verified by the human factor engineering. For the actual application to the operating plants, the drawings to be interconnected to the alarms and the opinions from the operators/maintenance departments for designating alarm number should be surveyed, Also, another function that allows the access to the alarm related drawings not only from the MCR but also from the other offices.

Development of Alarm System link Drawing for Operation Support for APR1400 Digital Main Control Room

International Nuclear Information System (INIS)

Kim, Ki-Hwan

2016-01-01

Digitalized MMI(Man-Machine Interface) including Digital Main Control Room(MCR) and digital I and C system was being applied for SKN 3 and 4 Nuclear Power Plant(NPP) and subsequent APR1400 NPP type. But, operators can not easily find instrument for alarm immediately. Therefore, Alarm system is required to easily find instrument for Alarm. For this implementation, we will plan system design considering design feature without affecting network load and CPU load. We have developed Alarm system link drawing for digital MCR. Operators of the digitalized MCR navigates from their consoles to the drawings related to the plant alarms and their instruments or the operation status. Such method gives cognitive load to the operators having to travel to different locations in finding the related information. Screen Sharing System, which is the fundamental technique for Drawing Interconnection Alarm System is close to completion, and it should be functionally tested and verified by the human factor engineering. For the actual application to the operating plants, the drawings to be interconnected to the alarms and the opinions from the operators/maintenance departments for designating alarm number should be surveyed, Also, another function that allows the access to the alarm related drawings not only from the MCR but also from the other offices

Réutilisation d'argiles très plastiques (A4) en remblai : Suivi du comportement après trois ans de réalisation

OpenAIRE

BERCHE, Véronique; ROBERT, Nicolas; BOUSSAFIR, Yasmina; FERBER, Valéry

2013-01-01

Cet article présente la réalisation de remblais en argile très plastiques en 2003 sur l'A34 dans les Ardennes (France) ainsi que les résultats du suivi du comportement de ces remblais dans le temps. Après un bref rappel des conditions de réalisation de ces remblais, un résumé des résultats de portance et de densité à court et moyen terme sera exposé. Dans un deuxième temps, des résultats de densité (double sonde Gamma et passage au banc Gamma) et essais Dynaplaque réalisés en 2006 seront c...

traitement chirurgical de l'hyper- parathyroidie primaire

African Journals Online (AJOL)

16 juin 2006 ... cas d'HPTHP et ses résultats dans le service d'ORL de Sfax. ... They are based currently on a effective exam of localization overhung by the scintigraphy to the ... 5,89 signes osseux tumeur brune signes rénaux. Autres signes.

Suivi après le traitement du cancer du sein

Science.gov (United States)

Sisler, Jeffrey; Chaput, Geneviève; Sussman, Jonathan; Ozokwelu, Emmanuel

2016-01-01

Résumé Objectif Offrir aux médecins de famille un résumé des recommandations fondées sur les données probantes pour guider les soins aux survivantes traitées pour le cancer du sein. Qualité des données Une recherche documentaire a été effectuée dans MEDLINE entre 2000 et 2016 à l’aide des mots-clés anglais suivants : breast cancer, survivorship, follow-up care, aftercare, guidelines et survivorship care plans, en se concentrant sur la revue des lignes directrices publiées récemment par les organismes nationaux de cancérologie. Les données étaient de niveaux I à III. Message principal Les soins aux survivantes comportent 4 facettes : surveillance et dépistage, prise en charge des effets à long terme, promotion de la santé et coordination des soins. La surveillance des récidives ne se traduit que par une mammographie annuelle, et le dépistage d’autres cancers doit suivre les lignes directrices basées sur la population. La prise en charge des effets à long terme du cancer et de son traitement aborde des problèmes courants tels la douleur, la fatigue, le lymphœdème, la détresse et les effets indésirables des médicaments, de même que les préoccupations à long terme comme la santé du cœur et des os. La promotion de la santé met en relief les bienfaits de l’activité chez les survivantes du cancer, avec l’accent mis sur l’activité physique. Les soins aux survivantes sont de meilleure qualité lorsque divers services et professionnels de la santé participent aux soins, et le médecin de famille joue un rôle important dans la coordination des soins. Conclusion Les médecins de famille sont de plus en plus souvent les principaux fournisseurs de soins de suivi après le traitement du cancer du sein. Le cancer du sein doit être considéré comme une affection médicale chronique, même chez les femmes en rémission, et les patientes profitent de la même approche que celle utilisée pour les autres affections chroniques en

Onset of liquid droplet entrainment on a direct vessel injection system for APR1400

Energy Technology Data Exchange (ETDEWEB)

Kim, Han-sol; Lee, Jae-Young [Handong Global University, Pohang (Korea, Republic of); Kim, Jong-Rok; Euh, Dong-Jin [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

In this research, a series of visualization works was conducted to understand droplet entrainment of the flow pattern generated in direct vessel injection system(DVI) of Korea nuclear power plant, APR 1400. In the emergency situation of a nuclear power plant, reliability of DVI cooling can be an important issue. It is known that, the amount and the rate of entrainment during the DVI cooling process can significantly affect the total heat removal. To visualize the film Reynolds number closely related with onset of droplet entrainment induced by falling film flow and lateral air flow in a small gap, confocal chromatic sensing method for measuring accurately film thickness and depth averaging particle image velocimetry for film velocity were used. The results have been post processed 4G Insight software. By measuring two dimensional film Reynolds number, we can predict the onset of droplet entrainment and obtain visible breakup region intuitively. To visualize the droplet entrainment induced by falling film flow and lateral air flow in a small gap, shadowgraph method with CCD camera (2200fps, 1280 pixel X 800 pixel, ) on coated plate with super water-repellent agent was used. The results have been post processed using 4G Insight software. By measuring two dimensional film Reynolds number, we can predict the onset of droplet entrainment and obtain visible breakup region intuitively. By adopting both super hydrophobic coating method and shadowgraph method, entrainment in a narrow gap was successfully visualized that has rarely performed before and meaningful results for DVI system research fields have been made.

Onset of liquid droplet entrainment on a direct vessel injection system for APR1400

International Nuclear Information System (INIS)

Kim, Han-sol; Lee, Jae-Young; Kim, Jong-Rok; Euh, Dong-Jin

2016-01-01

In this research, a series of visualization works was conducted to understand droplet entrainment of the flow pattern generated in direct vessel injection system(DVI) of Korea nuclear power plant, APR 1400. In the emergency situation of a nuclear power plant, reliability of DVI cooling can be an important issue. It is known that, the amount and the rate of entrainment during the DVI cooling process can significantly affect the total heat removal. To visualize the film Reynolds number closely related with onset of droplet entrainment induced by falling film flow and lateral air flow in a small gap, confocal chromatic sensing method for measuring accurately film thickness and depth averaging particle image velocimetry for film velocity were used. The results have been post processed 4G Insight software. By measuring two dimensional film Reynolds number, we can predict the onset of droplet entrainment and obtain visible breakup region intuitively. To visualize the droplet entrainment induced by falling film flow and lateral air flow in a small gap, shadowgraph method with CCD camera (2200fps, 1280 pixel X 800 pixel, ) on coated plate with super water-repellent agent was used. The results have been post processed using 4G Insight software. By measuring two dimensional film Reynolds number, we can predict the onset of droplet entrainment and obtain visible breakup region intuitively. By adopting both super hydrophobic coating method and shadowgraph method, entrainment in a narrow gap was successfully visualized that has rarely performed before and meaningful results for DVI system research fields have been made

Author Details

African Journals Online (AJOL)

2016) - Articles Un cas d'angiosarcome de l'oreille externe. Abstract PDF · Vol 25, No 1 (2016) - Articles Tumeur phyllode chez une jeune adolescente de 12 ans: à propos d'un cas et revue de la littérature. Abstract · Vol 25, No 1 (2016) - Articles

African Journal of Neurological Sciences 2013 - Vol. 32, No 1 http ...

African Journals Online (AJOL)

Service de Neurochirurgie, Hôpital Avicenne, Rabat. 2. Service de neuroradiologie, Rabat, Royaume du Maroc. Mots clés : Epidermoïde - Intra médullaire - IRM - Kyste - Moelle spinale. Keywords: Cyst - Epidermoid - Intramedullary -Medullary spinal -MRI. RESUME. Introduction. Les kystes épidermoïdes sont des tumeurs ...

Case report

African Journals Online (AJOL)

abp

21 mars 2014 ... Interne, Hôpital Militaire Avicenne, Marrakech, Maroc. &Corresponding author: Hicham Baïzri, Service d'Endocrinologie Diabétologie et Maladies Métaboliques, Hôpital Militaire Avicenne, Avenue. Moukaouama 40000, Marrakech, Maroc. Key words: Ganglioneurome, tumeurs rétropéritonéales, TDM, IRM.

Development of the APR1400 model for countercurrent natural circulation in hot leg and steam generator under station blackout

International Nuclear Information System (INIS)

Park, Sang Gil; Kim, Han Chul

2012-01-01

In order to analyze severe accident phenomena, Korea Institute of Nuclear Safety (KINS) made a MELCOR model for APR1400 to examine natural circulation and creep rupture failure in the Reactor Coolant System (RCS) under station blackout (SBO). In this study, we are trying to advance the former model to describe natural circulation more accurately. After Fukushima accident, the concerns of severe accident management, assuring the heat removal capability, has risen for the case when the SBO is happened and there are no more electric powers to cool down decay heat. Under SBO there are three kinds of natural circulation which can delay the core heatup. One is in vessel natural circulation in the upper plenum of reactor vessel and the second is countercurrent natural circulation in hot leg through steam generator tubes and the last is full loop natural circulation when the reactor coolant pump loop seal is cleared and reactor coolant pump sealing is damaged by high temperature and high pressure. Among them this study focuses on the countercurrent natural circulation model using MELCOR1.8.6

Air clearing pressure oscillation produced in a quenching tank by a prototype unit cell sparger of the APR1400

International Nuclear Information System (INIS)

Cho, Seok; Song, Chul-Hwa; Park, Choon-Kyong; Kim, Hwan-Yeol; Baek, Won-Pil

2008-01-01

KAERI has performed a series of experiments to investigate the performance of a prototype sparger for the APR1400 in view of a dynamic load oscillation with a variation of the test conditions such as a discharged air mass, a submergence of the sparger, the valve opening time, and the pool temperature during an air clearing phase. The air mass and pool temperature are in the range of 0.8-1.5 kg and 20-90 o C, respectively. The valve opening time can be adjusted within the range of 0.6-1.8 s. The maximum positive pressure amplitude, which is observed at the bottom of the quenching tank, is increased with the maximum header pressure of the sparger. The valve opening time has a considerable effect on the maximum amplitude. As the opening time decreases, the maximum amplitude at the tank wall is increased. Air mass and pool temperature, however, have a weak effect on the maximum amplitude. Oscillation frequency is decreased with an increase of the air mass in the range of 2.5-4.5 Hz

LES CANCERS DE L'ORBITE

African Journals Online (AJOL)

19 déc. 2007 ... té au type histologique permet d'améliorer la survie et la qualité de vie chez les patients atteints de ces tumeurs. Mots-clés ... management of these tumors. Materials ... La durée moyenne d'évolution de la symptomatologie.

Identification of sulfur-cycle prokaryotes in a low-sulfate lake (Lake Pavin) using aprA and 16S rRNA gene markers.

Science.gov (United States)

Biderre-Petit, Corinne; Boucher, Delphine; Kuever, Jan; Alberic, Patrick; Jézéquel, Didier; Chebance, Brigitte; Borrel, Guillaume; Fonty, Gérard; Peyret, Pierre

2011-02-01

Geochemical researches at Lake Pavin, a low-sulfate-containing freshwater lake, suggest that the dominant biogeochemical processes are iron and sulfate reduction, and methanogenesis. Although the sulfur cycle is one of the main active element cycles in this lake, little is known about the sulfate-reducer and sulfur-oxidizing bacteria. The aim of this study was to assess the vertical distribution of these microbes and their diversities and to test the hypothesis suggesting that only few SRP populations are involved in dissimilatory sulfate reduction and that Epsilonproteobacteria are the likely key players in the oxidative phase of sulfur cycle by using a PCR aprA gene-based approach in comparison with a 16S rRNA gene-based analysis. The results support this hypothesis. Finally, this preliminary work points strongly the likelihood of novel metabolic processes upon the availability of sulfate and other electron acceptors.

Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

Science.gov (United States)

Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

2011-01-01

Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

Voir tous les projets | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

causant les tumeurs) qui vise à interrompre l'expansion des cellules ayant un potentiel de malignité. Région(s): Canada, Israel, Brazil. Financement total : CA$ 669,800.00. Le rôle de l'IL6 dans le cancer du foie lié à l'hépatopathie métabolique.

African Journal of Neurological Sciences - 2009 Vol. 28 No 1

African Journals Online (AJOL)

l'Institut d'Ophtalmologie Tropicale d'Afrique (IOTA) estimait à 31,6% les pathologies tumorales oculo- ... (SNCLF), corroborant la littérature, la pathologie tumorale orbitaire concerne surtout les adultes féminins .... La chirurgie des tumeurs orbitaires par voie neurochirurgicale est recommandée pour des lésions à cheval.

Case report

African Journals Online (AJOL)

abp

21 oct. 2015 ... Abstract. Le Cylindrome orbitaire (carcinome adénoide kystique) est une tumeur maligne d'agressivité locale et d'évolution lente. Sa localisation orbitaire aux dépens des glandes lacrymales est exceptionnelle. Nous rapportons le cas d'un patient de 51 ans consultant pour une exophtalmie gauche non.

Pratiques, objets et finalités de collaboration en lien avec l’intégration des tablettes numériques dans une école secondaire | Practices, Objects and Collaboration Purposes Related to the Integration of Digital Tablets in a High School

Directory of Open Access Journals (Sweden)

Nadia Cody

2016-08-01

Full Text Available Bien que les technologies de l’information et de la communication (TIC occupent une place de plus en plus prépondérante, tant au sein de la société que de l’école (Anderson, 2010, on remarque que leur intégration en contexte scolaire représente encore un défi de taille (Underwood et Dillon, 2011. Selon certains auteurs (Portelance, 2011; Desgagné, 1997, la collaboration constituerait un vecteur pour transformer les pratiques éducatives. Comment la collaboration peut-elle contribuer à ce changement que représente l’intégration des TIC? Les résultats d’une recherche-action, menée depuis trois ans de concert avec une école secondaire ayant pour objectif d’intégrer la tablette numérique, permet de mettre en lumière des pratiques, des objets et des finalités de collaboration qui ont émergé entre les différents acteurs, favorisant ainsi l’implantation de cet outil technologique. Although Information and Communication Technologies (ICT play an increasingly predominant role (Anderson, 2010, their integration in school context is still a challenge (Underwood and Dillon, 2011. According to Portelance (2011 and Desgagné (1997, collaboration is one vector that can be used to transform educational practices. How can collaboration contribute to the ICT integration process into our schools? The results of an action research, conducted for three years along with a high school that aims to integrate digital tablet, allows to highlighting practices, objects and collaboration purposes that emerged between actors, therefore facilitating the implementation of this technological tool.

SCURTĂ PRIVIRE FILOSOFICO-JURIDICĂ ASUPRA CETĂŢENIEI UNIUNII EUROPENE

Directory of Open Access Journals (Sweden)

Ioan Huma

2007-05-01

Full Text Available Dans l’esprit des Traités de Maastricht et d’Amsterdam, la citoyenneté de l’UE nesaurait être un type en soi et pour soi de citoyenneté, situé à côté de, au-dessus de ou enopposition avec celle nationale ; elle se légitime simplement par son support et corrélatnational. A son tour, elle peut aiguillonner la citoyenneté nationale, en en entretenant laconscience critique des limites, mais aussi son aspiration de s’auto dépasser par des actes decréation. Voilà pourquoi la citoyenneté, si - d’un point de vue ontologique - elle revêt uncaractère secondaire, elle n’est aucunement secondaire dans sa finalité axiologique etintégrative.

African Journal of Neurological Sciences - 2009 Vol. 28 No 1

African Journals Online (AJOL)

examen ophtalmologique a été normal. On a noté une absence de tumeur thoraco-abdomino-pelvienne à la TDM et une MAPA en faveur d'une HTA limite et labile. L'IRM cérébrale était normale. Le test génétique a permis de retrouver une.

Consideration on hydrogen explosion scenario in APR 1400 containment building during small breakup loss of coolant accident

Energy Technology Data Exchange (ETDEWEB)

Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical & Energy Systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of)

2015-11-15

Highlights: • Hydrogen behavior in the containment building of APR1400 nuclear plant up to 15 h after the failure happened. • The risk of hydrogen explosion largely depends on the combination of air, hydrogen and steam in the containment. • Hydrogen explosion risk at different locations in the containment was analyzed. - Abstract: This paper describes the analytical result of the potential risk of hydrogen gas up to 15 h after the failure takes place. The major cause of the disaster occurred in Fukushima Daiichi nuclear reactor was the detonation of accumulated hydrogen in the containment by highly increased reactor core temperatures after the failure of the emergency cooling system. The hydrogen risk should be considered in severe accident strategies in current and future NPPs. A hydrogen explosion scenario is proposed. Hydrogen is accumulated on top of the dome during the hydrogen release period. At this point, there are no risk of explosion due to the steam that resides in upper part of the dome. As the hydrogen concentration increase, substantial amount of steams are released. Subsequently, hydrogen is forced into the lower part of the building with high air density—small explosion and dormant steam condensation phase are possible. The light hydrogen rises up slowly with air, gathering on top of the building with high air density. Massive hydrogen explosion is anticipated upon ignition at this stage.

A study on the hydrogen behavior and its mitigation in the APR1400 containment during a severe accident

International Nuclear Information System (INIS)

Kim, Jong Tae; Hong, Seong Wan; Park, Rae Joon; Kim, Sang Baik

2005-02-01

During a hypothetical severe accident in a nuclear power plant (NPP), hydrogen is generated by the active reaction of fuel-cladding and steam in the reactor pressure vessel and released with steam into the containment. In this study, the analysis of the hydrogen and steam behavior during selected severe accidents in the APR1400 containment has been conducted by using the GASFLOW code. For the SBLOCA, hydrogen was accumulated in the containment dome region quickly when only PARSs were used. When the igniters were turned on, a standing flame was formed around a coolant pump and burnt most of the hydrogen blown-out. For the TLOFW accident, the flap-type pressure damper installed at the IRWST vents strongly affected the flow structure of the hydrogen. And by the steam-rich and oxygen starvation conditions in the IRWST, DDT is not likely to occur. For the SBO accident, dry hydrogen was release in the IRWST by the assumption of full condensation of the released steam in the IRWST water. In this case, the possibility of flame acceleration is high in the IRWST and annular compartment. In this study two design modifications were proposed in view of the hydrogen mitigation strategy and their effectiveness was evaluated by the GASFLOW analysis

Case report

African Journals Online (AJOL)

ebutamanya

10 juin 2015 ... pathologique complétée par l'immuno-marquage est revenue en faveur d'une tumeur juvénile de la granulosa. .... Google Scholar. 5. Tinsley Schumer S, Cannistra A. Granulosa cell tumor of the ovary. Journal of clinical oncology. 2003 Mar 15;21(6):1180-9. PubMed | Google Scholar. 6. Calaminus G ...

Mise au point

African Journals Online (AJOL)

7 mai 2012 ... nasal fossa tumor in 29 patients (93.5%) and mucosa hypertrophy in the 2 others. Six patients had associated cervical lymphadenopathies. Sinonasal CT showed extension to .... œdème jugal et périorbitaire homolatéral. L'endoscopie nasale a objectivé une tumeur des fosses nasales chez 29 patients (93 ...

India | Page 62 | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

Read more about Profiling eIF2a-Dependent Translation in Synaptic Plasticity and Memory. Language English. Read more about Transformation des découvertes en génomique pour soigner les tumeurs cérébrales ultrahypermutantes déficientes en système de réparation des mésappariements. Language French.

MAQUETTE ORL Décembre 2004

African Journals Online (AJOL)

Le bilan d'extension doit donc comporter systématiquement une radiographie du thorax, une échographie abdominale et une scintigraphie osseuse. Le pronostic du carcinome adénoïde kystique, tumeur plus agressive, est grevé d'une lourde mortalité à court terme. (10). Notre patiente est toujours en vie au terme de deux.

Case report

African Journals Online (AJOL)

abp

9 mai 2014 ... Affection rare dans le monde, la mucocèle appendiculaire ou tumeur mucosécrétante appendiculaire est définie comme une distension liquidienne de la lumière appendiculaire par accumulation de mucus. La distension mucineuse de la lumière appendiculaire peut être d'origine tumorale ou non, bénigne ...

TUMEUR ORBITAIRE: MANIFESTATION INITIALE D'UNE MALADIE ...

African Journals Online (AJOL)

L'hétérogénéité et la rareté des formes multicentriques de la maladie de Castleman font que leurs traitements soient très disparates. La maladie de Castleman doit être considérée comme un diagnostic possible d'une adénopathie cervicale particulièrement chez les patients souffrant d'une maladie inflammatoire chronique.

Valutazione dell'appropriatezza dei ricoveri in un Policlinico Universitario: analisi mediante l'uso comparativo dei sistemi di classificazione isogravitá APR-DRG e Disease Staging e del PRUO

Directory of Open Access Journals (Sweden)

M. Volpe

2003-05-01

Full Text Available

Obiettivi: valutare l’appropriatezza organizzativa dei ricoveri effettuati in un Policlinico Universitario attraverso la comparazione di due metodi, dei quali uno basato sui dati della scheda di dimissione ospedaliera ed utilizza, rispettivamente, i sistemi di classificazione iso-gravità APR-DRG e Disease Staging e l’altro sulla revisione delle cartelle cliniche mediante il PRUO.

Metodi: oggetto di analisi sono i ricoveri ordinari effettuati nell’anno 2001 ed afferenti ai DRG inclusi nella delibera della Giunta Regionale del Lazio 864/2002 che recepisce il D.P.C.M. 29/11/2001 sui livelli essenziali di assistenza.

Risultati: i risultati evidenziano che le due varianti del
metodo basato sulla SDO (metodo APPRO mostrano quote di ricoveri inappropriati sovrapponibili rispetto al complesso dei ricoveri oggetto di analisi, ma con differenze anche rilevanti tra APR-DRG e Disease Staging in relazione ai singoli DRG considerati, riconducibili ai diversi algoritmi di attribuzione del livello di severità utilizzati dai due sistemi. L’analisi campionaria effettuata con il metodo PRUO su casi afferenti ai DRG della DGR 864/2002 caratterizzati da livelli di severità minimi evidenzia una proporzione di ricoveri inappropriati superiore a quella determinata tramite i metodi basati sulla SDO. Tale differenza è verosimilmente dovuta al ruolo del valore delle soglie percentuali di accettabilità individuate dalla Regione Lazio per ciascun DRG: le quote di ricoveri che eccedono tali soglie sono considerate inappropriate.

Conclusioni: sulla base dei risultati ottenuti gli autori
descrivono gli interventi organizzativi adottati per ottimizzare il contesto di erogazione delle prestazioni
oggetto di analisi, discutono vantaggi e limiti dei metodi SDO-based e del metodo analitico PRUObased e ne propongono l�

Evolution de la gonadotropine plasmatique t-GtH après synchronization des ovulations par injection de 17α hydroxy-20β dihydroprogesterone chez la truite arc-en-ciel (Salmo gairdneri R.) : Evolution of plasmatic gonadotropin t-gth after synchronization of ovulations by injection of 17-α hydroxy-20β dihydroprogesterone in rainbow-trout (Salmo gairdneri R.)

OpenAIRE

Jalabert, Bernard; Breton, Bernard; Bry, C.

1980-01-01

L'injection de 17α hydroxy-20 β dihydroprogestérone (3 mg/kg) à des femelles dont les ovocytes sont au stade de « vésicule germinative semi-périphérique » entraîne une chute du niveau de t-GtH, très hautement significative 24 h. après injection, qui résulte vraisemblablement d'une rétroaction négative sur la sécrétion hypophysaire. Par la suite, après ovulation, la t-GtH plasmatique s'élève davantage chez les femelles subissant la rétention des ovules (50 µg/ml environ) que chez les femelles ...

Suivi prospectif sur 5 ans des tentatives de suicide en population clinique dans la région de Fès, Maroc

Science.gov (United States)

Aarab, Chadya; Elghazouani, Fatima; Aalouane, Rachid; Rammouz, Ismail

2014-01-01

Au Maroc, les tentatives de suicide (TS) demeurent un sujet mal évalué à cause de considérations socioculturelles et l'absence d'approche longitudinale. L'objectif principal était d’évaluer le devenir des suicidants après 5ans au centre universitaire psychiatrique de Fès, les objectifs secondaires étaient l'estimation de la prévalence des TS, préciser les étiologies les plus fréquentes, et établir une corrélation entre les paramètres sociodémographiques, cliniques et évolutifs. Etude prospective à visée transversale et longitudinale, incluant les suicidants vus à l'hôpital psychiatrique de Fès, avec un suivi longitudinal sur 5ans. L’évaluation a été faite par un hétéro-questionnaire et le Mini International Neuropsychiatric Interview (MINI) cherchant le trouble psychiatrique sous jacent. On a recruté 105 patients suicidants, 62% des femmes, l’âge moyen est de 29,23ans. La prévalence des tentatives de suicide est de 3% sur l'ensemble des consultants à l’établissement. Les troubles de l'humeur, psychotiques et de personnalité ont occupé respectivement 37,6%, 27,7%, et 25,7% des cas. La récidive suicidaire a été notée chez 54% des patients, était significativement corrélée à la vie solitaire (P: 0,039) et à la présence d'antécédents familiaux de TS (P: 0,046). L'utilisation de moyens violents était significativement fréquente chez les patients psychotiques. Après 5ans, 32 patients ont répondu à notre appel. Le taux de récidive était de 15%. On a noté trois cas de décès dont deux suicides confirmés. Les résultats confirment les données de la littérature scientifique avec certaines particularités cliniques et évolutives. PMID:25478042

Review on the NEI Methodology of Debris Transport Analysis in Sump Blockage Issue for APR1400

International Nuclear Information System (INIS)

Kim, Jong Uk; Lee, Jeong Ik; Hong, Soon Joon; Lee, Byung Chul; Bang, Young Seok

2007-01-01

Since USNRC (United State Nuclear Regulatory Committee) initially addressed post-accident sump performance under Unresolved Safety Issue USI A-43, sump blockage issue has gone through GSI-191, Regulation Guide 1.82, Rev. 3 (RG. 1.82 Rev.3), and generic Letter 2004-02 for PWRs (Pressurized Water Reactors). As a response of these USNRC's activities, NEI 04-07 was issued in order to evaluate the post-accident performance of a plant's recirculation sump. The baseline methodology of NEI 04-07 is composed of break selection, debris generation, latent debris, debris transport, and head loss. In analytical refinement of NEI 04-07, computational fluid dynamic (CFD) is suggested for the evaluation of debris transport in emergency core cooling (ECC) recirculation mode as guided by RG. 1.82 Rev.3. In Korea nuclear industry also keeps step with international activities of this safety issue, with Kori 1 plant as a pioneering edge. Korean nuclear industry has been also pursuing development of an advanced PWR of APR1400, which incorporates several improved safety features. One of the key features, considering sump blockage issue, is the adoption of IRWST (In-containment Refueling Water Storage Tank). This device, as the acronym implies, changes the emergency core cooling water injection pattern. This fact makes us to review the applicability of NEI 04-07's methodology. In this paper we discuss the applicability of NEI 04- 07's methodology, and more over, new methodology is proposed. And finally the preliminary debris transport is analyzed

The fifteenth period report on the cooperative utilization of the AVF cyclotron at Osaka University RCNP (Dec 1982 - Apr 1983)

International Nuclear Information System (INIS)

1984-01-01

The AVF cyclotron at the RCNP (Research Center for Nuclear Physics) of Osaka University has been cooperatively used by various researchers of Japanese universities or colleges. This collective report covers papers concerning various studies performed at the AVF during Dec 1982 to Apr 1983. Some of the titles of these papers are as follows : Elastic scattering of 56 MeV polarized deuterons from 12 C and 40 Ca ; Pionic three-nucleon capture reactions ; Measurement on branching ratios of short-lived beta emitter 23 Mg and its hyperfine interactions ; Half-life and branching ratios of short-lived beta emitter 13 O ; 7 Li excitation of the giant resonances in 208 Pb ; Measurements of spin polarization of residual nuclei after light particle emission in heavy ion reactions ; Target dependence of the sequential alpha decay through the narrow resonances of 20 Ne ; Analyzing power of neutron continuum spectra for the 93 Nb (p,nx) reaction and a simple one step OWBA analysis ; Energy dependence of the reaction mechanism for the 3 He and alpha induced reactions ; Medium energy gamma rays following radiative capture of polarized protons on light nuclei. (Aoki, K.)

Neurohypophysis granular cell tumours. Upon neurohypophysis rare tumours; Les tumeurs a cellules granuleuses. Des tumeurs rares de la neurohypophyse

Energy Technology Data Exchange (ETDEWEB)

Barrande, G.; Kujas, M.; Gancel, A.; Turpin, G.; Bruckert, E.; Kuhn, J.M.; Luton, J.P. [Hopital Cochin, 75 - Paris (France)

1995-10-01

Granular cell tumours of neurohypophysis are rare. These tumours are more often encountered as incidental autopsy findings seen in up to 17 % of unselected adult autopsy cases. There are few reports of para-sellar granular cell tumours large enough to cause symptoms. We present three cases of neurohypophysis granular cell tumour and a review of the literature. In one patient, the asymptomatic granular cell tumour was incidentally discovered at surgical removal of a corticotrophic micro-adenoma. The remaining 2 patients had a symptomatic tumour which caused neurological symptoms such as visual disturbance and headaches and endocrine disorders such as hypopituitarism or hyper-prolactinaemia. In these 2 cases, computerized tomography showed a well-circumscribed, contrast-enhanced, intra-sellar and supra-sellar mass. Magnetic resonance imaging demonstrated an isointense gadolinium-enhanced mass in T1-weighted-images. Trans-sphenoidal partial resection was performed and histology was interpreted as a granular cell tumour. The immunohistochemical study was positive for glial fibrillary acidic protein (GEAP) and neuron specific enolase (NSE) in 1 of the 2 tumours and positive for S100 protein and vimentin in both tumours but negative for CD68. The histogenesis of neurohypophysis granular cell tumours is still controversial but ultrastructural and immunohistochemical studies support the theory that may arise from pituicytes, the glial cells of neurohypophysis. Management of these benign, slow growing, tumours is based mainly on neurosurgical resection. Data from the literature do not support a beneficial effect of post operative radiation therapy on postoperative recurrences. (authors). 23 refs., 4 figs., 1 tab.

Browse Title Index

African Journals Online (AJOL)

Vol 9, No 1 (2011), Maladie de hodgkin et cancer colique secondaire: à propos ... de Leo-Buerger faisant suite à une intoxication au cannabis, Abstract PDF ... of Type 2 Diabetes Mellitus by Traditional Medicine Practitioners in Kenya- Key ...

Simple models for usual media of thermalization; Modeles simples pour les thermaliseurs usuels

Energy Technology Data Exchange (ETDEWEB)

Soule, J L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

One determines 'secondary models' of graphite, light water, heavy water and beryllium at different temperatures. (author) [French] On determine des 'modeles secondaires' du graphite, de l'eau legere, de l'eau lourde et du beryllium a differentes temperatures. (auteur)

L'endométriose pariétale cicatricielle après césarienne: une entité rare

Science.gov (United States)

El Fahssi, Mohammed; Lomdo, Massama; Bounaim, Ahmed; Ali, Abdelmounaim Ait; Sair, Khalid

2016-01-01

L'endométriose de la paroi est une entité clinique rare, dont la physiopathologie demeure imprécise. Elle survient le plus souvent après une intervention chirurgicale gynécologique ou obstétricale. Nous rapportons le cas d'une patiente présentant une douleur cyclique, au niveau de la cicatrice de césarienne, Avec à l'examen clinique une masse de 5cm localisée au niveau de la fosse iliaque droite. la tomodensitométrie montre une masse de densité tissulaire de 45mm de grand axe. D'où la décision d'excision large de la lésion dont l’étude anatomopathologique confirme le diagnostic d'endométriose pariétale. Les suites postopératoires étaient simples avec un recul de 20 mois sans récidive de la masse ni de la douleur. A travers notre cas, nous insisterons sur les caractéristiques de cette pathologie, ce qui permettra au praticien de comprendre l'intérêt du diagnostic et de la prise en charge précoce de cette affection ainsi que la possibilité de sa prévention au cours de chaque chirurgie gynécologique ou obstétricale. PMID:27642418

Browse Title Index

African Journals Online (AJOL)

Vol 23, No 1 (2016), Magnitude and correlates of moderate to severe anemia among adult ... Vol 9, No 1 (2011), Maladie de hodgkin et cancer colique secondaire: à ... de Leo-Buerger faisant suite à une intoxication au cannabis, Abstract PDF.

Pyélonéphrite xanthogranulomateuse bilatérale focale : à propos d’un cas

Science.gov (United States)

El Yacoubi, Souhail; Ziouziou, Imad; Zizi, Mohamed; Jahid, Ahmed; Karmouni, Tariq; El Khader, Khalid; Koutani, Abdellatif; Andaloussi, Ahmed Iben Attya

2014-01-01

Résumé Nous présentons l’observation clinique d’un cas rare de pyélonéphrite xanthogranulomateuse (PXG) bilatérale chez un jeune patient âgé de 17 ans. La découverte progressive de l’infection a débuté par l’apparition de lombalgies bilatérales évoluant depuis un mois, sans autre signe associé. L’urotomodensitométrie penchait en faveur de deux masses rénales bilatérales, soit une masse polaire inférieure droite et une masse polaire supérieure gauche, toutes deux de densité tissulaire. Une biopsie échoguidée a suggéré la présence d’une réaction inflammatoire non spécifique. Une néphrectomie partielle polaire inférieure droite a été effectuée devant la forte présomption de tumeurs rénales malignes. Finalement, l’histologie a orienté le diagnostic vers une PXG. Il s’agit, à notre connaissance, du sixième cas de PXG focale bilatérale rapporté dans la littérature. Notre patient a reçu un traitement antibiotique à base de fluoroquinolone pendant un mois. L’évolution clinique s’est avérée bonne, et les lésions visibles à la tomodensitométrie se sont entièrement résorbées au bout d’un mois. Le patient vit toujours après un an et présente une fonction rénale normale. PMID:25295145

L'endométriose de la paroi abdominale: à propos d'un cas rare

Science.gov (United States)

Jayi, Sofia; Laadioui, Meriem; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Aabdelilah

2013-01-01

L'endométriose de la paroi est une entité clinique rare, dont la physiopathologie demeure imprécise. Elle survient le plus souvent après une intervention chirurgicale gynécologique ou obstétricale. Nous rapportons le cas d'une patiente présentant une douleur cyclique, au niveau de la cicatrice de césarienne. Avec à l'examen clinique une masse de 3 cm localisée au niveau de la fosse iliaque droite. L'échographie-doppler a objectivé une image d'allure tissulaire, polylobée, à vascularisation centrale, mesurant 32/16 mm, évoquent une masse endométriosique ou une tumeur des parties molles. D'où la décision d'excision de la lésion, au cours de laquelle on a découvert une masse dure de 3/2 cm, en sous aponévrotique accolée au muscle grand droit de l'abdomen. L'étude anatomopathologique a confirmé le diagnostic d'endométriose pariétale. Les suites postopératoires étaient simples avec un recul de 2 ans et demie sans récidive de la masse ni de la douleur. A travers notre cas, nous insisterons sur les caractéristiques de cette pathologie notamment pronostic, ce qui permettra au praticien de comprendre l'intérêt du diagnostic et prise en charge précoce de cette entité - pour laquelle on ne pense jamais assez devant une masse pariétale - et de sa prévention au cours de chaque chirurgie gynécologique ou obstétricale. PMID:24171068

Feasibility Study of Core Design with a Monte Carlo Code for APR1400 Initial core

Energy Technology Data Exchange (ETDEWEB)

Kim, Jinsun; Chang, Do Ik; Seong, Kibong [KEPCO NF, Daejeon (Korea, Republic of)

2014-10-15

The Monte Carlo calculation becomes more popular and useful nowadays due to the rapid progress in computing power and parallel calculation techniques. There have been many attempts to analyze a commercial core by Monte Carlo transport code using the enhanced computer capability, recently. In this paper, Monte Carlo calculation of APR1400 initial core has been performed and the results are compared with the calculation results of conventional deterministic code to find out the feasibility of core design using Monte Carlo code. SERPENT, a 3D continuous-energy Monte Carlo reactor physics burnup calculation code is used for this purpose and the KARMA-ASTRA code system, which is used for a deterministic code of comparison. The preliminary investigation for the feasibility of commercial core design with Monte Carlo code was performed in this study. Simplified core geometry modeling was performed for the reactor core surroundings and reactor coolant model is based on two region model. The reactivity difference at HZP ARO condition between Monte Carlo code and the deterministic code is consistent with each other and the reactivity difference during the depletion could be reduced by adopting the realistic moderator temperature. The reactivity difference calculated at HFP, BOC, ARO equilibrium condition was 180 ±9 pcm, with axial moderator temperature of a deterministic code. The computing time will be a significant burden at this time for the application of Monte Carlo code to the commercial core design even with the application of parallel computing because numerous core simulations are required for actual loading pattern search. One of the remedy will be a combination of Monte Carlo code and the deterministic code to generate the physics data. The comparison of physics parameters with sophisticated moderator temperature modeling and depletion will be performed for a further study.

Syndrome de Sweet: étude clinique et natomopathologique sur 5 ans

African Journals Online (AJOL)

Des maladies associées étaient retrouvées chez 17 patients : hémopathies (deux cas), tumeur solide (1cas), maladie chronique de l'intestin (1cas), tuberculose (1 cas), diabète (trois cas) et infections (9 cas). Deux patientes étaient enceintes au moment du diagnostic. Les manifestations cutanées étaient polymorphes avec ...

Case report

African Journals Online (AJOL)

abp

31 oct. 2017 ... (1-3%) à triple composante graisseuse, musculaire lisse et vasculaire en proportions variables. Classiquement ce type de tumeur s'inscrit dans le cadre de la Sclérose Tubéreuse de. Bourneville (STB), L'atteinte rénale est alors multiple et bilatérale. Mais, l'angiomyolipome rénal peut être sporadique, isolé ...

Le léiomyome rétro-péritonéal: à propos de 2 cas | Yddoussalah ...

African Journals Online (AJOL)

intestinal et génito-urinaire, et rares au niveau rétro péritonéal.Leur prévalence parmi les tumeurs rétropéritonéales primitives a été estimée entre de 0,5 à 1,2%. Une situation qui conduit à des erreurs de diagnostic. On rapporte dans cet article ...

Case report

African Journals Online (AJOL)

ebutamanya

22 janv. 2015 ... Abstract. Les hémangiopéricytomes primitifs du système nerveux central sont rares et représentent moins de 1% des tumeurs intracraniennes. La localisation au niveau de l'angle ponto-cerebelleux est très rare, pouvant simuler un neurinome de l'acoustique ou un méningiome. Le diagnostic de certitude ...

MAQUETTE ORL Décembre 2004

African Journals Online (AJOL)

le cancer des VADS ainsi que ses thérapies, la recherche ... les cancers des VADS, il faut commencer très précocement avant même ... support should always be preferred. ... D'une manière générale, la tumeur se développe quelque .... patients pris en charge en ORL pour cancer des VADS .... Evaluation nutritionnelle.

Un incidentalome surrenalien inhabituel: le ganglioneurome

African Journals Online (AJOL)

S. Attafi

Résumé. Le ganglioneurome est une tumeur neurogène bénigne, rare, qui se développe à partir des cellules gan- glionnaires sympathiques. Elle se localise essentiellement dans la région rétropéritonéale. La localisation surrénalienne est rare. Nous rapportons un cas de ganglioneurome surrénalien chez une femme ...

: tous les projets | Page 42 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les tumeurs malignes au cerveau sont la cause la plus courante de décès chez les enfants atteints du cancer, mais il n'y a pas de traitement connu. Date de début : 1 décembre 2015. Sujet: BRAIN, MATERNAL AND CHILD HEALTH, CANCER, THERAPY, CANADA. Région: India, Canada. Programme: Fondements pour l' ...

MAQUETTE ORL Décembre 2004

African Journals Online (AJOL)

souvent indolore. Son histoire naturelle se fait vers lʼaug- mentation de volume et la dissémination métastatique ganglionnaire et pulmonaire essentiellement. Le pronostic est principalement lié à la taille de la tumeur. Le diagnos- tic se doit dʼêtre le plus précoce possible puisque le seul traitement efficace étant chirurgical ...

Phylogenetic diversity and spatial distribution of the microbial community associated with the Caribbean deep-water sponge Polymastia cf. corticata by 16S rRNA, aprA, and amoA gene analysis.

Science.gov (United States)

Meyer, Birte; Kuever, Jan

2008-08-01

Denaturing gradient gel electrophoresis (DGGE)-based analyses of 16S rRNA, aprA, and amoA genes demonstrated that a phylogenetically diverse and complex microbial community was associated with the Caribbean deep-water sponge Polymastia cf. corticata Ridley and Dendy, 1887. From the 38 archaeal and bacterial 16S rRNA phylotypes identified, 53% branched into the sponge-specific, monophyletic sequence clusters determined by previous studies (considering predominantly shallow-water sponge species), whereas 26% appeared to be P. cf. corticata specifically associated microorganisms ("specialists"); 21% of the phylotypes were confirmed to represent seawater- and sediment-derived proteobacterial species ("contaminants") acquired by filtration processes from the host environment. Consistently, the aprA and amoA gene-based analyses indicated the presence of environmentally derived sulfur- and ammonia-oxidizers besides putative sponge-specific sulfur-oxidizing Gammaproteobacteria and Alphaproteobacteria and a sulfate-reducing archaeon. A sponge-specific, endosymbiotic sulfur cycle as described for marine oligochaetes is proposed to be also present in P. cf. corticata. Overall, the results of this work support the recent studies that demonstrated the sponge species specificity of the associated microbial community while the biogeography of the host collection site has only a minor influence on the composition. In P. cf. corticata, the specificity of the sponge-microbe associations is even extended to the spatial distribution of the microorganisms within the sponge body; distinct bacterial populations were associated with the different tissue sections, papillae, outer and inner cortex, and choanosome. The local distribution of a phylotype within P. cf. corticata correlated with its (1) phylogenetic affiliation, (2) classification as sponge-specific or nonspecifically associated microorganism, and (3) potential ecological role in the host sponge.

Ar neatliekamās medicīniskās palīdzības brigādēm stacionārā nogādāto pacientu apmierinātība ar veselības aprūpi pirms stacionāra un stacionāra etapā

OpenAIRE

Dzene, Dace

2017-01-01

Autore: Dace Dzene, stud.apl.nr. dd15034 Darba vadītājs: Dr.med. Igors Ivanovs Ar neatliekamās medicīniskās palīdzības brigādēm stacionārā nogādāto pacientu apmierinātība ar veselības aprūpi pirms stacionāra un stacionāra etapā. Maģistra darbs, Latvijas universitāte, Rīga, 2017. Darbs sastāv no teorētiskās un empīriskās daļas, 6 nodaļām, 66 lapām, 29 attēliem, 10 tabulām, 2 pielikumiem. Pētījuma mērķis ir noskaidrot pacientu apmierinātību ar saņemto veselības aprūpes kvalitāti pirms st...

phytochemical study and evaluation of the antimicrobial and ...

African Journals Online (AJOL)

30 juin 2014 ... CARACTERISATION DES SUBSTANCES PRIMAIRES ET SECONDAIRES DE ..... Médecine arabe ancienne et ... Identification, Préparation, Soin. .... [32] Euzeby J.P. Abrégé de Bactériologie Générale et Médicale à l'usage ...

Knowledge, Perceptions and Ever Use of Modern Contraception ...

African Journals Online (AJOL)

Erah

service- and knowledge-related barriers to use (Afr J Reprod Health 2010; 14[4]: 27-32). Résumé. Connaissance ... obstacle et 65% des utilisatrices ont déclaré au moins un effet secondaire. Dans un .... pharmacies, and other social marketing.

Protection for work in the pressure tank of the pile G2; Protection des travaux dans le caisson de la pile G2

Energy Technology Data Exchange (ETDEWEB)

Chassany, J Ph; Rodier, J [Commissariat a l' Energie Atomique, Service de Protection contre les Radiations, Marcoule (France). Centre d' Etudes Nucleaires

1961-07-01

While the pile was shut down after a three-month run at full power, the secondary circuit was cleaned and some alterations were carried out. The pile contained 100 tons of uranium, half of which made up the periphery and was irradiated uranium. The possibility of carrying on work inside the pressure tank was not considered at the time of construction. Because of the heat and the irradiation it was only possible to remain in the pressure tank for a limited period of time, and several operators received doses of the order of 1.5 rem. Cotton clothing gave satisfactory protection against contamination and was more comfortable than the vinyl equipment. The work lasted for 17 days and involved 881 incursions into the pressure tank. (author) [French] Un nettoyage et des modifications ont ete realises dans le circuit secondaire pendant l'arret de la pile apres un fonctionnement de trois mois a pleine puissance. La pile contenait 100 tonnes d'uranium dont la moitie, composant la peripherie, etait de l'uranium irradie. La possibilite d'entreprendre un travail a l'interieur du caisson n'avait pas ete envisage lors de la construction. Le temps de sejour dans le caisson etait a la fois limite par l'irradiation et la chaleur, plusieurs operateurs, ont integre une dose de l'ordre de 1,5 rem. Les vetements de coton ont apporte une protection contre la contamination satisfaisante et un confort relatif par rapport aux equipements de vinyle. L'intervention a dure 17 jours, a comporte 881 entrees dans le caisson. (auteur)

2572-IJBCS-Article-Yapi Adon Basile

African Journals Online (AJOL)

hp

des plantes médicinales est le fait de métabolites primaires et surtout secondaires. ... la médecine moderne, certaines affections ..... Anémie, Fatigue générale, Maladie de la peau, Rhumatisme ..... dans la couverture des soins de santé.

Profil épidémiologique, diagnostique, thérapeutique et évolutif du ...

African Journals Online (AJOL)

K. Tengue

Épidémiologie diagnostic;. Traitement; ... soit 6,4 % et le traitement hormonal dans 93,1 % des cas. Le taux de décès .... avaient permis la recherche de localisation secondaire et la classi- .... de plateau technique adéquat dans nos structures.

Untitled

African Journals Online (AJOL)

5 cm de la marge anale, à surface lisse et. Le tératome est une tumeur qui se contours réguliers. développe au dépend de trois cellules souches embryonnaires (ectodermiques, L'échographie abdominopelvienne a endodermiques et mésodermique)". Il siège le montré une masse rétrovésicale, homogène, plus souvent au ...

African Journal of Neurological Sciences - 2009 Vol. 28 No 1

African Journals Online (AJOL)

transcisternale antéro-médiale pour atteindre la corne temporale. Cette voie permet d'éviter les lésions de la boucle antérieure des radiations optiques à condition qu'une retraction rigide ne soit pas appliquée au lobe temporal. Les tumeurs isolées de la corne occipitale peuvent être traité par un abord occipital ou un abord.

Angiomyolipome rénal agressif avec extension à la veine rénale: à ...

African Journals Online (AJOL)

Exceptionnellement la tumeur peut avoir un caractère agressive avec extension locorégionale et veineuse (la veine rénale et la veine cave inferieure). Nous présentons une observation d'une patiente âgée de 37 ans présentant un Angiomyolipome rénal volumineux avec extension à la veine rénale. Mots clés: Rein ...

Case series

African Journals Online (AJOL)

abp

28 mai 2014 ... Abstract. Le mélanome malin des fosses nasales est une tumeur rare mais très agressive, de traitement complexe et de pronostic défavorable. Son traitement relève en principe d'une prise en charge essentiellement chirurgicale complétée par une radiothérapie. L'objectif de ce travail est de rapporter les ...

Hematome organise du sinus maxillaire a propos d'un cas | Beltaief ...

African Journals Online (AJOL)

L'hématome organisé du sinus maxillaire est une entité rare. Son étiopathogénie reste incertaine. Nous rapportons le cas d'une patiente âgée de 16 ans présentant une épistaxis unilatérale droite de grande abondance avec une endoscopie nasale strictement normale. L'imagerie était en faveur d'une tumeur vasculaire du ...

Existe-t-il une corrélation entre la taille tumorale au scanner et les caractéristiques anatomopathologiques du cancer du rein?

Directory of Open Access Journals (Sweden)

Y. Kharbach

2015-03-01

Conclusion: La présente étude réaffirme la précision de la TDM pour prédire la taille des tumeurs rénales mesurée à l’anatomopathologie, d’établir le renal score afin de mieux orienter le choix thérapeutique et de prédire les caractéristiques anatomopathologique du carcinome à cellules rénales.

Leiomyome agressif naso-sinusien : a propos d'un cas et revue de ...

African Journals Online (AJOL)

Introduction : Les léiomyomes sont des tumeurs bénignes issues des fibres musculaires lisses. La localisation au niveau des cavités nasosinusiennes est très rare. Cas clinique : Il s'agit d'une patiente âgée de 59 ans, qui a consulté pour obstruction nasale et épistaxis gauches. L'endoscopie nasale a montré une formation ...

La chronologie du royaume de Qatabân du Ier siècle avant J.-C. au Ier siècle après J.-C.

Directory of Open Access Journals (Sweden)

Mounir Arbach

2002-04-01

Full Text Available Les nouvelles découvertes archéologiques et épigraphiques de ces dernières années, effectuées au cours des fouilles franco-italiennes à Tamna`, l'ancienne capitale du royaume de Qatabân, permettent d'établir une nouvelle chronologie des souverains de Qatabân entre le Ier siècle avant J.-C. et le Ier siècle après J.- C.The chronology of the kingdom of Qatabân, from the 1st century BC to the 1st century AD. Archaeological and epigraphical discoveries made in recent years by the Franco-Italian excavations at Tamna`, the ancient capital of the kingdom of Qatabân, allows us to establish a new chronology for the kings of Qatabân during the 1st century BC and the 1st century AD.

Analysis of Post-LOCA Core Inlet Blockage to Evaluate In-vessel Downstream Effect in APR1400

International Nuclear Information System (INIS)

Bang, Young Seok

2015-01-01

The method was developed to have a conservatism to cover the uncertainty of analysis and the acceptance is judged by the representative bounding estimation. However, the important safety parameters such as the available driving head need to be confirmed by the plant specific calculation. Also an interaction between the debris induced head loss and the core flow rate needs to be explained because the head loss induced by debris in actual condition may reduce the core inflow rate faster. To confirm the safety parameters, in this study, thermal-hydraulic response considering the core inlet blockage (CIB) by debris during LTCC process following a double-ended guillotine break of cold leg (CLB), one of hot leg (HLB) and one of intermediate leg (ILB) of the APR1400 were calculated, respectively. MARS-KS 1.3 code has been used. The CIB has been modeled by the closure of valves to the core in exponential manner with time to observe the behavior near the complete blockage. To understand the effect of core inlet blockage (CIB) during a long term core cooling (LTCC) phase following a loss-of-coolant accident (LOCA) in the light of in-vessel downstream effect (IDE) of Generic Safety Issue (GSI) 191, double-ended guillotine break of hot leg (HLB), one of cold leg (CLB) and one of intermediate leg (ILB) were calculated, respectively. And the important safety parameters such as the available driving head and the head loss due to debris were calculated using MARS-KS code and discussed in comparison with the WCAP method. As a result, a little delayed heatup behavior of the fuel cladding was found for all the cases, which due to the redistribution of flow within the core after blockage

Analysis of Post-LOCA Core Inlet Blockage to Evaluate In-vessel Downstream Effect in APR1400

Energy Technology Data Exchange (ETDEWEB)

Bang, Young Seok [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2015-10-15

The method was developed to have a conservatism to cover the uncertainty of analysis and the acceptance is judged by the representative bounding estimation. However, the important safety parameters such as the available driving head need to be confirmed by the plant specific calculation. Also an interaction between the debris induced head loss and the core flow rate needs to be explained because the head loss induced by debris in actual condition may reduce the core inflow rate faster. To confirm the safety parameters, in this study, thermal-hydraulic response considering the core inlet blockage (CIB) by debris during LTCC process following a double-ended guillotine break of cold leg (CLB), one of hot leg (HLB) and one of intermediate leg (ILB) of the APR1400 were calculated, respectively. MARS-KS 1.3 code has been used. The CIB has been modeled by the closure of valves to the core in exponential manner with time to observe the behavior near the complete blockage. To understand the effect of core inlet blockage (CIB) during a long term core cooling (LTCC) phase following a loss-of-coolant accident (LOCA) in the light of in-vessel downstream effect (IDE) of Generic Safety Issue (GSI) 191, double-ended guillotine break of hot leg (HLB), one of cold leg (CLB) and one of intermediate leg (ILB) were calculated, respectively. And the important safety parameters such as the available driving head and the head loss due to debris were calculated using MARS-KS code and discussed in comparison with the WCAP method. As a result, a little delayed heatup behavior of the fuel cladding was found for all the cases, which due to the redistribution of flow within the core after blockage.

Case series

African Journals Online (AJOL)

ebutamanya

23 oct. 2015 ... secondaires à des agressions physiques sur une durée de trois ans. Les critères d'inclusion ... morceaux de verre. Dans notre série .... contre les comportements agressifs; les médias devront éliminer la diffusion de portraits ...

Encéphalopathie de Gayet-Wernicke compliquant des ...

African Journals Online (AJOL)

L'encéphalopathie de Gayet-Wernicke est une complication neuropsychiatrique aiguë secondaire à une carence en thiamine. Les vomissements incoercibles compliquant une obstruction intestinale chronique en sont une cause rare. Nous rapportons un cas d'encéphalopathie de Gayet-Wernicke compliquant des ...

Case report

African Journals Online (AJOL)

ebutamanya

3 juil. 2015 ... Abstract. L'encéphalopathie de Gayet-Wernicke est une complication neuropsychiatrique aiguë secondaire à une carence en thiamine. Les vomissements incoercibles compliquant une obstruction intestinale chronique en sont une cause rare. Nous rapportons un cas d'encéphalopathie de Gayet-.

President Meri kutsub lapsi üles koguma mälestusi küüditamisest / Lennart Meri

Index Scriptorium Estoniae

Meri, Lennart, 1929-2006

2001-01-01

President Lennart Meri korraldab enne oma ametiaja lõppu suurejoonelise konkursi, millega kutsub 5.-11. klasside õpilasi koguma mitme põlvkonna mälestusi küüditamisest. Ilmunud ka: Postimees, 11. apr. 2001, lk. 17; Maaleht, 12. apr. 2001, lk. 8; Hiiumaa, 10. apr. 2001, lk. 1; Lääne Elu, 10. apr. 2001, lk. 5; Põhjarannik, 10. apr. 2001, lk. 7; Virumaa Teataja, 11. apr. 2001, lk. 7; Valgamaalane, 12. apr. 2001, lk. 5; Sakala, 11. apr. 2001, lk. 2; Koit, 12. apr. 2001, lk. 7; Nädaline, 12. apr. 2001, lk. 3; Meie Maa, 11. apr. 2001, lk. 2; Hiiu Leht, 12. apr. 2001, lk. 2; Eesti Kirik, 18. apr. 2001, lk. 1; Järva Teataja, 17. apr. 2001, lk. 2; Sirp, 20. apr. 2001, lk. 2; Sillamjaeskii Vestnik, 19. apr. 2001, lk. 1; Õpetajate Leht, 20. apr. 2001, lk. 10; Den za Dnjom, 20. apr. 2001, lk. 9; Narvskaja Gazeta, 26. apr. 2001, lk. 3.

Uus valitsus kordab eelkäija vigu / Ivari Padar

Index Scriptorium Estoniae

Padar, Ivari, 1965-

2005-01-01

Ilmunud ka Nädaline 14. apr., lk. 4, Järva Teataja 14. apr., lk. 2, Põhjarannik 14. apr., lk. 2, Severnoje Poberezhje 14. apr., lk. 2, Koit 14. apr., lk. 6, Virumaa Teataja 15. apr., lk. 7, Vali Uudised 15. apr., lk. 2, Hiiu Leht 15. apr., lk. 2, Kuuulutaja 15. apr., lk. 4, Virumaa Nädlalaht 15. apr. lk. 3, Võrumaa Teataja 16. apr. lk. 2, Sakala 19. apr. lk. 2, Videvik 21. apr. lk. 3, Pärnu Postimees 6. mai lk. 15. Sotsiaaldemokraatide arvamus uuest valitsuslepingust

Barriers to Systemic, Effective, and Sustainable Technology Use in High School Classrooms / Obstacles à l’utilisation systémique, efficace et durable de la technologie dans les salles de classe des écoles secondaires

Directory of Open Access Journals (Sweden)

Jason Scott Daniels

2014-01-01

Full Text Available The purpose of the Technology and High School Success (THSS initiative was to encourage innovative strategies focused on improving provincial high school completion rates, using technology and student-centered learning to engage student interest. The primary purpose of this paper is to report on barriers that impede systemic, effective and sustainable technology integration within schools. Even with teacher and administrative support and commitment for THSS, evaluative research indicated minimal change in system capacity as a result of the initiative. Three primary barriers to program sustainability were: 1 schools and school districts did not leverage the opportunity to revisit their existing vision(s, 2 schools and school districts did not use data to make changes, and 3 limited access to technology. Le but de l’initiative « Technology and High School Success (THSS » était d'encourager des stratégies novatrices visant à améliorer le taux d’achèvement des études secondaires dans la province de l’Alberta en utilisant la technologie et un apprentissage centré sur l'élève afin de susciter l'intérêt des élèves. L'objectif principal de cet article est de rendre compte des obstacles entravant l'intégration systémique, efficace et durable de la technologie dans les écoles. La recherche évaluative a révélé des changements minimes dans la capacité systémique à la suite de l'initiative, et ce, malgré l’appui et l’engagement des enseignants et des administrateurs envers le THSS. Les trois obstacles principaux à la viabilité du programme sont les suivants: 1 les écoles et les districts scolaires n'ont pas profité de l’occasion pour revoir leur(s vision(s, 2 les écoles et les districts scolaires n'ont pas utilisé les données pour effectuer des changements, et 3 l'accès limité à la technologie.

Nighttime Near Infrared Observations of Augustine Volcano Jan-Apr, 2006 Recorded With a Small Astronomical CCD Camera

Science.gov (United States)

Sentman, D.; McNutt, S.; Reyes, C.; Stenbaek-Nielsen, H.; Deroin, N.

2006-12-01

Nighttime observations of Augustine Volcano were made during Jan-Apr, 2006 using a small, unfiltered, astronomical CCD camera operating from Homer, Alaska. Time-lapse images of the volcano were made looking across the open water of the Cook Inlet over a slant range of ~105 km. A variety of volcano activities were observed that originated in near-infrared (NIR) 0.9-1.1 micron emissions, which were detectable at the upper limit of the camera passband but were otherwise invisible to the naked eye. These activities included various types of steam releases, pyroclastic flows, rockfalls and debris flows that were correlated very closely with seismic measurements made from instruments located within 4 km on the volcanic island. Specifically, flow events to the east (towards the camera) produced high amplitudes on the eastern seismic stations and events presumably to the west were stronger on western stations. The ability to detect nighttime volcanic emissions in the NIR over large horizontal distances using standard silicon CCD technology, even in the presence of weak intervening fog, came as a surprise, and is due to a confluence of several mutually reinforcing factors: (1) Hot enough (~1000K) thermal emissions from the volcano that the short wavelength portion of the Planck radiation curve overlaps the upper portions (0.9-1.1 micron) of the sensitivity of the silicon CCD detectors, and could thus be detected, (2) The existence of several atmospheric transmission windows within the NIR passband of the camera for the emissions to propagate with relatively small attenuation through more than 10 atmospheres, and (3) in the case of fog, forward Mie scattering.

Predictors of exclusive breastfeeding: observations from the Alberta pregnancy outcomes and nutrition (APrON) study.

Science.gov (United States)

Jessri, Mahsa; Farmer, Anna P; Maximova, Katerina; Willows, Noreen D; Bell, Rhonda C

2013-05-16

Despite growing evidence that supports the importance of 6-month exclusive breastfeeding, few Canadian mothers adhere to this, and early weaning onto solids is a common practice. This study assessed infant feeding transitions during the first 6 months postpartum and factors that predicted exclusive breastfeeding to 3 and 6 months. This prospective cohort study was part of the Alberta Pregnancy Outcomes and Nutrition study (APrON). From an initial sample of 600 pregnant women recruited from Edmonton and Calgary, 402 mothers provided complete details at 3 months postpartum; 300 stayed on to provide information at 6 months postpartum. During pregnancy and at 3 and 6 months postpartum, data on maternal and infant socio-demographic, behavior, and feeding were collected. Even though there was a high rate of "ever having breastfed" (98.6%), exclusive breastfeeding rates for 3 and 6 months were 54.0% and 15.3%, respectively. After controlling for potential confounders, the study showed that mothers who held post-graduate university degrees were 3.76 times more likely to breastfeed exclusively for 6 months than those without a university degree (95% CI: 1.30-10.92; p = 0.015). In addition, mother of previous children were more likely to breastfeed exclusively for 6 months (OR: 2.21, 95% CI: 1.08-4.52; p = 0.031). Mothers who were in the highest quartile of the Iowa Infant Feeding Attitude Score were 4.29 and 5.40 times more likely to breastfeed exclusively for 3 months (95% CI: 1.31-14.08; p-trend < 0.001) and 6 months (95% CI: 2.75-10.60; P-trend < 0.001), respectively. The 6-month exclusive breastfeeding rate in Alberta is considerably below national and international breastfeeding recommendations. Professional advice that focuses on prenatal maternal knowledge, attitudes, and misperceptions may promote adherence to World Health Organization breastfeeding guidelines. Knowing that exclusive breastfeeding is less likely to take place among lower

Predictors of exclusive breastfeeding: observations from the Alberta pregnancy outcomes and nutrition (APrON) study

Science.gov (United States)

2013-01-01

Background Despite growing evidence that supports the importance of 6-month exclusive breastfeeding, few Canadian mothers adhere to this, and early weaning onto solids is a common practice. This study assessed infant feeding transitions during the first 6 months postpartum and factors that predicted exclusive breastfeeding to 3 and 6 months. Methods This prospective cohort study was part of the Alberta Pregnancy Outcomes and Nutrition study (APrON). From an initial sample of 600 pregnant women recruited from Edmonton and Calgary, 402 mothers provided complete details at 3 months postpartum; 300 stayed on to provide information at 6 months postpartum. During pregnancy and at 3 and 6 months postpartum, data on maternal and infant socio-demographic, behavior, and feeding were collected. Results Even though there was a high rate of “ever having breastfed” (98.6%), exclusive breastfeeding rates for 3 and 6 months were 54.0% and 15.3%, respectively. After controlling for potential confounders, the study showed that mothers who held post-graduate university degrees were 3.76 times more likely to breastfeed exclusively for 6 months than those without a university degree (95% CI: 1.30-10.92; p = 0.015). In addition, mother of previous children were more likely to breastfeed exclusively for 6 months (OR: 2.21, 95% CI: 1.08-4.52; p = 0.031). Mothers who were in the highest quartile of the Iowa Infant Feeding Attitude Score were 4.29 and 5.40 times more likely to breastfeed exclusively for 3 months (95% CI: 1.31-14.08; p-trend breastfeeding rate in Alberta is considerably below national and international breastfeeding recommendations. Professional advice that focuses on prenatal maternal knowledge, attitudes, and misperceptions may promote adherence to World Health Organization breastfeeding guidelines. Knowing that exclusive breastfeeding is less likely to take place among lower-educated, primiparous women may help health practitioners focus their

Extension of Surveillance Test Interval of Safety Injection Pump for APR-1400 Reactors to Improve Reliability and Availability of the Pump

Energy Technology Data Exchange (ETDEWEB)

Osama, A. Rezk; Jung, J. C.; Lee, Yong-Kwan [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2015-10-15

The safety features function to localize, control, mitigate, and terminate such incidents and to hold exposure levels below applicable limits. The safety injection system is comprised of four independent mechanical trains without any tie line among the injection paths and two electrical divisions. Each train has one active Safety Injection Pump (SIP) and one passive Safety Injection Tank (SIT) equipped with a Fluidic Device (FD), each train provides 50% of the minimum injection flow rate for breaks larger than the size of a direct vessel injection line. For breaks equal to or smaller than the size of a direct vessel injection line, each train has 100% of the required capacity. The low pressure injection pumps with common header installed in the conventional design are eliminated, and the functions for safety injection and shutdown cooling are separated. The arrangement of safety injection system for APR-1400 as shown in figure (1). The results obtained in this work show that STI extensions for the SIS feasible without any unacceptable increase in the plant total risk, STI extensions are acceptable for safety injection system to provide plant operational flexibility in the performance of both corrective and preventive maintenance for the safety injection system.

Les tumeurs intraventriculaires de l'encephale | Haidara | African ...

African Journals Online (AJOL)

African Journal of Neurological Sciences. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 28, No 1 (2009) >. Log in or Register to get access to full text downloads.

Radiotherapy and skin tumors; Radiotherapie et tumeurs curanees

Energy Technology Data Exchange (ETDEWEB)

Calitchi, E.; KIrova, Y.; Le bourgeois, J.P. [Hopital Henri-Mondor, 94 - Creteil (France)

1998-09-01

Radiotherapy plays an important role in treatment of skin tumours. For skin carcinomas, external irradiation (kilo-voltage X-rays or electrons according to clinical characteristics) is more valuable than interstitial brachytherapy, which is recommended for tumours of the lip and of the nasal vestibule. In mycosis fungoides, total cutaneous electron beam radiation therapy is efficient for patients with limited superficial plaques. In the classical form of Kaposi`s sarcoma, radiotherapy can achieve local control-whereas it obtains good palliative results in the epidemic form. (author)

coloproctectomie avec anastomose colo-sus-anale pour tumeur ...

African Journals Online (AJOL)

Une coloproctectomie fut réalisée le 30/06/2014 avec anastomose colo-anale, colostomie de protection sous-couvert d'une transfusion sanguine. L'examen histologique du segment colorectal prélevé objectiva une rectocolite granulomateuse autour de nombreux oeufs de schistosomes. En effet, le patient a vécu à Pahou, ...

MAQUETTE ORL Décembre 2004

African Journals Online (AJOL)

3 : Actine musculaire lisse(+). Cet examen concluait au diagnostic de fasciite nodulaire. Une exérèse de la tumeur fut alors programmée. Elle fut menée sous anesthésie générale, par voie endobuccale avec section autour du pédicule en muqueuse saine. (Figure 4). Fig. 4 : Pièce opératoire. Les suites opératoires furent ...

L'adénome métanéphrique bilatéral du rein

African Journals Online (AJOL)

ra

L'adénome métanéphrique du rein est une tumeur épithéliale bénigne rare. Son diagnostic est exclusivement histologique. Le diagnostic différentiel se fait essentiellement avec le néphroblastome et le carcinome papillaire à cellules rénales. L'étude cytogénétique apporte des éléments importants pour différencier entre ...

African Journal of Neurological Sciences 2010 - Vol. 29, No 2 http ...

African Journals Online (AJOL)

une tumeur agressive et rapidement métastatique. Il siège essentiellement au niveau des extrémités, la sphère ORL et urogénitale. La localisation paravertébrale avec extension endocanalaire est très rare (6). Nous rapportons un cas de rhabdomyosarcome paravertébral chez une fille de 6 ans révélé par un tableau.

CARCINOME ANAPLASIQUE DE LA THYROÏDE: A PROPOS DE ...

African Journals Online (AJOL)

16 juin 2006 ... Introduction : le carcinome anaplasique de la thyroïde est une tumeur rare, mais agressive. Le but de notre travail est d'étudier les aspects cliniques et de discuter les modalités thérapeutiques de ce cancer. Matériel et méthodes : Il s'agit d'une étude rétrospective de 11 cas de carcinomes anaplasiques de ...

Case report

African Journals Online (AJOL)

raoul

30 mars 2011 ... Une prise en charge multidisciplinaire basée sur une chirurgie large et une radiothérapie externe adjuvante systématique, est le seul garant d´une bonne évolution voire de la guérison de cette tumeur particulièrement rare et agressive. Conflit d'intérêts. Les auteurs ne déclarent aucun conflit d'intérêts ...

LES OSTEOMES SINUSIENS A ExTENSION ORBITAIRE A ...

African Journals Online (AJOL)

gine de la constitution d'une néoformation osseuse. Enfin selon une théorie embryologique, l'ostéome résulterait de l'ossification du cartilage fœtal situé à la jonction du sinus frontal et ethmoïdal (3). Sur le plan clinique, les ostéomes sont souvent asymptomatiques lorsque la tumeur est de petite taille et située a distance de ...

Tuumajaam Eestisse - otstarbekas ja paratamatu? / Harri Õunapuu

Index Scriptorium Estoniae

Õunapuu, Harri, 1947-

2008-01-01

Ilmunud ka: Hiiu Leht 11. apr., lk. 2, Harju Ekspress 11. apr., lk. 6, Sakala 11. apr., lk. 2, Kuulutaja 11. apr. lk. 4, Elva Postipoiss 12. apr., lk. 4, Koit 12. apr. lk. 6, Meie Maa 14. apr. lk. 2, Järva Teataja 15. apr. lk. 2, Põhjarannik 16. apr., lk. 2, Severnoje Poberezhje 16. apr. lk. 2, Vooremaa 19. apr. lk. 2, Lääne Elu 26. apr. lk. 2, Paremad Uudised apr. nr. 3 lk. 7, Virumaa Teataja 26. juuni lk. 11, Nädalaleht 11. apr. lk. 2. Riigikogu liikme hinnangul on tuumaenergia kui praktiliselt heitmevaba energialiik tõsiseltvõetav alternatiiv Eesti heitainemahuka elektritootmise nüüdisajastamisel. Riigikogu peaks vastu võtma põhimõttelise seisukoha tuumaenergeetika osas

Pidamata jäänud kõne / Imre Sooäär

Index Scriptorium Estoniae

Sooäär, Imre, 1969-

2007-01-01

Ilmunud ka: Lääne Elu, 10. apr. 2007, lk. 2; Hiiu Leht, 10. apr. 2007, lk. 2; Põhjarannik, 10. apr. 2007, lk. 2; Severnoje Poberezhje, 10. apr. 2007, lk. 2; Harjumaa, 10. apr. 2007, lk. 2; Virumaa Teataja, 12. apr. 2007, lk. 11; Nädaline, 12. apr. 2007, lk. 2; Sakala, 13. apr. 2007, lk. 2; Harju Ekspress, 13. apr. 2007, lk. 6; Vali Uudised, 13. apr. 2007, lk. 2; Järva Teataja, 14. apr. 2007, lk. 2; Vooremaa, 14. apr. 2007, lk. 2. Parlamendiliige leiab, et Ene Ergma oli parim Riigikogu XI koosseisu kandidaat spiikri kohale

Study of contamination by 100 {mu}Ci of Sr 90 in the rat: clinical, hematological and osseous effects (appearance of osteosarcomas); Etude d'une contamination par 100 {mu}Ci de Sr 90 chez le rat: consequences cliniques, hematologiques et osseuses (apparition d'osteosarcomes)

Energy Technology Data Exchange (ETDEWEB)

Graf, B.; Lafuma, J.; Parmentier, C.; Parmentier, N. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1968-07-01

Clinical, hematological and osseous effects following an intramuscular injection of 100 {mu}Ci 90 Sr were studied in the rat. In spite of the magnitude of the injection and the resulting damage, the elimination of strontium could compare with what occurs after an injection at tracer doses. Comparing with the controls at the outcoming time, clinical monitoring mainly brought out a loss of body weight. Fairly early (20. - 30. day) there occurred severe hematological damage, especially on lymphocyte line, which subsided spontaneously. As foreseen, the anatomo-pathological survey of the early period showed bone and medullar lesions in the areas of enchondral ossification. In the late period, bone sarcomas occurred in nine animals out of ten. The outstanding histological type was osteogenic osteosarcomas; besides, two animals experienced bilateral tumors. (authors) [French] Les auteurs etudient les consequences cliniques, hematologiques et osseuses d'une contamination par 100 microcuries de Sr 90 injectes par voie intramusculaire chez le rat. Malgre l'importance de la contamination et les lesions consequentes, l'elimination du Sr 90 est comparable a celle que l'on observe apres injection de doses traceuses. La surveillance clinique ne met essentiellement en evidence, a la periode terminale, qu'une diminution du poids par rapport aux temoins. Les lesions hematologiques sont importantes, predominant sur la lignee lymphocytaire. Elles sont relativement precoces (20e - 30e jours) et regressent spontanement. La surveillance anatomo-pathologique de la periode precoce a montre, comme il etait previsible, des lesions osseuses et medullaires dans les zones d'ossification enchondrale. A la periode tardive, la survenue de sarcomes osseux a ete observee chez neuf animaux sur dix. Le type histologique predominant est l'osteosarcome osteogenique et il faut signaler egalement les tumeurs bilaterales observees chez deux animaux. (auteurs)

Study of contamination by 100 {mu}Ci of Sr 90 in the rat: clinical, hematological and osseous effects (appearance of osteosarcomas); Etude d'une contamination par 100 {mu}Ci de Sr 90 chez le rat: consequences cliniques, hematologiques et osseuses (apparition d'osteosarcomes)

Energy Technology Data Exchange (ETDEWEB)

Graf, B; Lafuma, J; Parmentier, C; Parmentier, N [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1968-07-01

Clinical, hematological and osseous effects following an intramuscular injection of 100 {mu}Ci 90 Sr were studied in the rat. In spite of the magnitude of the injection and the resulting damage, the elimination of strontium could compare with what occurs after an injection at tracer doses. Comparing with the controls at the outcoming time, clinical monitoring mainly brought out a loss of body weight. Fairly early (20. - 30. day) there occurred severe hematological damage, especially on lymphocyte line, which subsided spontaneously. As foreseen, the anatomo-pathological survey of the early period showed bone and medullar lesions in the areas of enchondral ossification. In the late period, bone sarcomas occurred in nine animals out of ten. The outstanding histological type was osteogenic osteosarcomas; besides, two animals experienced bilateral tumors. (authors) [French] Les auteurs etudient les consequences cliniques, hematologiques et osseuses d'une contamination par 100 microcuries de Sr 90 injectes par voie intramusculaire chez le rat. Malgre l'importance de la contamination et les lesions consequentes, l'elimination du Sr 90 est comparable a celle que l'on observe apres injection de doses traceuses. La surveillance clinique ne met essentiellement en evidence, a la periode terminale, qu'une diminution du poids par rapport aux temoins. Les lesions hematologiques sont importantes, predominant sur la lignee lymphocytaire. Elles sont relativement precoces (20e - 30e jours) et regressent spontanement. La surveillance anatomo-pathologique de la periode precoce a montre, comme il etait previsible, des lesions osseuses et medullaires dans les zones d'ossification enchondrale. A la periode tardive, la survenue de sarcomes osseux a ete observee chez neuf animaux sur dix. Le type histologique predominant est l'osteosarcome osteogenique et il faut signaler egalement les tumeurs bilaterales observees chez deux animaux. (auteurs)

Seitse miljardit veemajandusele / Rein Randver

Index Scriptorium Estoniae

Randver, Rein, 1956-

2007-01-01

Ilmunud ka: Sakala, 3. apr. 2007, lk. 2; Võrumaa Teataja, 3. apr. 2007, lk. 2; Vooremaa, 3. apr. 2007, lk. 2; Vali Uudised, 4. apr. 2007, lk. 2; Meie Maa, 4. apr. 2007, lk. 2; Põhjarannik, 4. apr. 2007, lk. 2; Severnoje Poberezhje, 4. apr. 2007, lk. 2; Harju Ekspress, 5. apr. 2007, lk. 8; Harjumaa, 5. apr. 2007, lk. 4; Lääne Elu, 10. apr. 2007, lk. 2; Oma Saar, 13. apr. 2007, lk. 5. Ametist lahkuv keskkonnaminister peab kõige olulisemaks ja rahaliselt suuremahulisemaks tegevusvaldkonnaks veemajandust

Proceedings: Pacific Northwest Council on Foreign Languages. Volume XXX, Part 2.

Science.gov (United States)

Mazur, Gertrud S., Ed.

The following papers of relevance to second language instruction are compiled here: (1) "Bilingual Math in a Monolingual Classroom: A Field Study," by Elizabeth M. Baricevic; (2) "Ideologie et pedagogie: reflexions sur le manuel de francais au programme de '3e annee secondaire' en Algerie," by Jeanne Adam; (3) "Pedagogic…

Vers l'integration des textes dans le programme du fran9ais langue ...

African Journals Online (AJOL)

Au Malawi, on enseigne le fran9ais en tant que langue etrangere depuis une quarantaine d'annees .... !'organisation institutionnelle du systeme educatif du Malawi, le palier secondaire en ... Les objectifs du type : rediger une lettre, decrire une .... nouveau (rheme). Charolles souligne qu'il s'agit d'une performance delicate.

Lähme, naised / Tiina Kuuler

Index Scriptorium Estoniae

Kuuler, Tiina, 1969-

2008-01-01

Muusikasündmustest: Rebecca "Inglite pisarad" 10. apr. Tallinnas Toompeal Nelipühi kirikus, "Puhkpilliorkester Tartu 60" 6. apr. Vanemuise kontserdimajas, Singer-Vinger 4. apr. Tallinnas Rock Cafés, "Kolumbus Kris 21" 11. apr. Rock Cafés, "Rock & Roll City" 5. apr. Rock Cafés, Voiceboys 4. apr. Vanemuise kontserdimajas, 5. apr. Jõhvi kontserdimajas ja 6. apr. Estonia kontserdisaalis, "The Musigue Bazaar" 4. apr. Tartus baaris Tige Tikker, Clubarena sünnipäev 4. apr. Tallinnas Mustpeade majas (vt. www.clubarena.com)

Loodus ja inimesed on ühtemoodi olulised / Jaanus Tamkivi

Index Scriptorium Estoniae

Tamkivi, Jaanus, 1959-

2007-01-01

Ilmunud ka: Hiiu Leht (lüh.), 17. apr. 2007, lk. 2; Oma Saar, 17. apr. 2007, lk. 5; Harjumaa, 17. apr. 2007, lk. 2; Vooremaa, 17. apr. 2007, lk. 2; Sõnumitooja, 18. apr. 2007, lk. 2; Lääne Elu, 18. apr. 2007, lk. 2; Valgamaalane, 19. apr. 2007, lk. 2; Virumaa Teataja, 19. apr. 2007, lk. 11; Koit, 19. apr. 2007, lk. 6; Järva Teataja, 21. apr. 2007, lk. 2; Põhjarannik, 21. apr. 2007, lk. 2; Severnoje Poberezhje, 21. apr. 2007, lk. 2. Keskkonnaminister Jaanus Tamkivi sõnul hakkab PRIA, lisaks poollooduslike koosluste toetustele, uue maaelu arengukava raames maksma Natura 2000 toetust põllumajandusmaadele ning erametsaomanikud võivad taotlema hakata saamata jäänud tulu kompenseerimist

PRIMA-1 and PRIMA-1Met (APR-246: From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies

Directory of Open Access Journals (Sweden)

Anne Perdrix

2017-12-01

Full Text Available p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the protein. Accordingly, reactivation of p53 appears as a quite promising pharmacological approach and, effectively, several attempts have been made in that sense. The most widely investigated compounds for this purpose are PRIMA-1 (p53 reactivation and induction of massive apoptosis and PRIMA-1Met (APR-246, that are at an advanced stage of development, with several clinical trials in progress. Based on publications referenced in PubMed since 2002, here we review the reported effects of these compounds on cancer cells, with a specific focus on their ability of p53 reactivation, an overview of their unexpected anti-cancer effects, and a presentation of the investigated drug combinations.

Images in medicine

African Journals Online (AJOL)

abp

1 oct. 2015 ... maxillaires et un larmoiement. L'inspection a montré une hémiface fortement déformée par une tuméfaction lisse faisant huit centimètres de grand axe (A,B), de consistance dure à la palpation. La rhinoscopie antérieure a révélé dans la cavité nasale gauche une tumeur lisse, blanchâtre, non hémorragique ...

Vol. 9, No. 3, 200:3

African Journals Online (AJOL)

notre patient. Chez la femme, les tumeurs de l'urètre antérieur se manifestent plutôt par une urétrorragie, une dysurie, ou même par une masse perçue au méat ... Le traitement du cancer de l'urètre fait appel à la chirurgie, à la radiothérapie et à la chimiothérapie”. La Chirurgie”1o. Elle peut être conservatrice ou mutilante.

metastase cervicale d'un adenome pleomorphe cervical metastasis ...

African Journals Online (AJOL)

tic demeure bon. Cependant, les risques évolutifs de cette tumeur, avec un potentiel létal non négligeable, impose une surveillance régulière et prolongée des adénomes pléo- morphes opérés, surtout en cas de récidives locales. Un traitement initial adéquat de l'AP, consistant en une paroti- dectomie exofaciale ou totale ...

Esimene neljandik / Ela Tomson

Index Scriptorium Estoniae

Tomson, Ela, 1945-

2004-01-01

Ilmunud ka: Põhjarannik, 15. apr. 2004, lk. 2; Severnoje Poberezhje, 15. apr. 2004, lk. 2; Koit, 15. apr. 2004, lk. 6; Hiiumaa, 16. apr. 2004, lk. 2; Meie Maa, 16. apr. 2004, lk. 2; Võrumaa Teataja, 17. apr. 2004, lk. 2; Valgamaalane, 17. apr. 2004, lk. 2; Pärnu Postimees, 20. apr. 2004, lk. 15; Hiiu Leht, 20. apr. 2004, lk. 2. Ülevaade Riigikogu töö esimesest neljandikust, olulisematest saavutustest: vanemapalga kehtestamine ja lastetoetuse kahekordistamine, pensionitõus

Case series

African Journals Online (AJOL)

ebutamanya

25 mai 2015 ... antécédents, les données de l'examen clinique général et de l'examen ... centre de soins. Les informations sur nos ... patientes ayant le niveau primaire ou secondaire représentaient ..... FES Maroc: Faculté de médecine et de.

DJODJOUWIN 2.xps

African Journals Online (AJOL)

HP Pro 2000

guinéennes au Bénin. Terminalia superba est un arbre caractéristique des forêts denses semi-décidues, envahissant les recrûs secondaires. L'espèce est grégaire, de pleine lumière et à croissance rapide. Holoptelea grandis est une espèce exigeante.

Priapisme induit par la chlorpromazine: A propos de deux cas

Directory of Open Access Journals (Sweden)

I. Marrag

2016-06-01

Le priapisme veineux est une urgence urologique. Il constitue un des effets secondaires des neuroleptiques parmi les quels la chlorpromazine. Cet effet iatrogène, qui est rare mais grave, doit être connu par les cliniciens afin d’être mieux prévenu pour éviter les séquelles érectiles.

Case report

African Journals Online (AJOL)

ebutamanya

29 mai 2015 ... d'un patient de 58 ans, diabétique et tabagique chronique ayant présenté une nécrose ... diabète type 2, découvert il y a 5 ans, sous antidiabétique oraux, ... troubles de coagulation secondaire à une maladie néoplasique, les.

Analysis of a molten pool natural convection in the APR1400 RPV at a severe accident

International Nuclear Information System (INIS)

Kim, Jong Tae; Park, Rae Joon; Kim, Sang Baik

2005-01-01

During a hypothetical severe accident, reactor fuel rods and structures supporting them are melted and relocated in the lower head of the reactor vessel. These relocated molten materials could be separated by their density difference and construct metal/oxide stratified pools in the lower head. A decay heat generated from the fuel material is transferred to the vessel wall and upper structures remaining in the reactor vessel by natural convection. As shown in Fig. 1 two-layered stratified molten pool is developed in the reactor lower vessel. The oxidic pool usually constructed by the mixture of uranium oxide and zirconium oxide. The melting temperature of the oxidic material is very high compared to the steel vessel and metallic layer. And highly turbulent natural convection generated by the decay heat enhances heat transfer to the boundary of the oxidic pool. By this thermal mechanism, oxide curst is developed around the oxidic layer as shown in Fig. 1. The oxidic pool is bounded thermally and fluid-dynamically by the developed crust. By this boundedness, the heat transfer structure in the stratified oxidic/metallic pool can be solved separately. The thermal boundary condition of the oxidic pool is isothermal with constant melting temperature of the oxidic material. The decay heat is transfer to side wall and upper interface between oxidic and metallic layer. Turbulent natural convection is dominant heat transfer mechanism in the oxidic pool. The heat transferred from the bottom oxidic layer is imposed to the upper metallic layer. This transferred heat in the metallic pool is removed through side and upper surface, which is augmented also by natural convection developed in the pool. In this study, a molten pool natural convection in the APR1400 RPV during a severe accident is simulated using the Lilac code and the calculated heat flux distribution on the reactor vessel wall is compared with a lumped-parameter (LP) prediction

Rehepapid ja peremehed / Hannes Astok

Index Scriptorium Estoniae

Astok, Hannes, 1964-

2007-01-01

Ilmunud ka: Järva Teataja, 26. apr. 2007, lk. 2; Võrumaa Teataja, 26. apr. 2007, lk. 2; Vooremaa, 26. apr. 2007, lk. 2; Põhjarannik, 26. apr. 2007, lk. 2; Severnoje Poberezhje, 26. apr. 2007, lk. 2; Lääne Elu, 26. apr. 2007, lk. 2; Pärnu Postimees, 27. apr. 2007, lk. 15; Hiiu Leht, 27. apr. 2007, lk. 2; Koit, 28. apr. 2007, lk. 6; Sakala, 8. mai 2007, lk. 2. Parlamendiliige mõtestab lahti intellektuaalse omandi päeva mõtte

Dictyostelium cells bind a secreted autocrine factor that represses cell proliferation.

Science.gov (United States)

Choe, Jonathan M; Bakthavatsalam, Deenadayalan; Phillips, Jonathan E; Gomer, Richard H

2009-02-02

Dictyostelium cells secrete the proteins AprA and CfaD. Cells lacking either AprA or CfaD proliferate faster than wild type, while AprA or CfaD overexpressor cells proliferate slowly, indicating that AprA and CfaD are autocrine factors that repress proliferation. CfaD interacts with AprA and requires the presence of AprA to slow proliferation. To determine if CfaD is necessary for the ability of AprA to slow proliferation, whether AprA binds to cells, and if so whether the binding requires the presence of CfaD, we examined the binding and effect on proliferation of recombinant AprA. We find that the extracellular accumulation of AprA increases with cell density and reaches a concentration of 0.3 microg/ml near a stationary cell density. When added to wild-type or aprA- cells, recombinant AprA (rAprA) significantly slows proliferation at 0.1 microg/ml and higher concentrations. From 4 to 64 microg/ml, the effect of rAprA is at a plateau, slowing but not stopping proliferation. The proliferation-inhibiting activity of rAprA is roughly the same as that of native AprA in conditioned growth medium. Proliferating aprA- cells show saturable binding of rAprA to 92,000 +/- 11,000 cell-surface receptors with a KD of 0.03 +/- 0.02 microg/ml. There appears to be one class of binding site, and no apparent cooperativity. Native AprA inhibits the binding of rAprA to aprA- cells with a Ki of 0.03 mug/ml, suggesting that the binding kinetics of rAprA are similar to those of native AprA. The proliferation of cells lacking CrlA, a cAMP receptor-like protein, or cells lacking CfaD are not affected by rAprA. Surprisingly, both cell types still bind rAprA. Together, the data suggest that AprA functions as an autocrine proliferation-inhibiting factor by binding to cell surface receptors. Although AprA requires CfaD for activity, it does not require CfaD to bind to cells, suggesting the possibility that cells have an AprA receptor and a CfaD receptor, and activation of both receptors is

Elame üheskoos kaua ja tervelt / Maret Maripuu

Index Scriptorium Estoniae

Maripuu, Maret, 1974-

2008-01-01

Ilmunud ka: Den za Dnjom 11. apr. lk. 18-19, Virumaa Teataja 18. apr., lk. 11, Harju Ekspress 18.apr., lk. 6, Harju Elu 18. apr., lk. 2, Türi Rahvaleht 18. apr. lk. 4, Põhjarannik 19. apr., lk. 2, Severnoje Poberezhje 19. apr. lk. 2. Sotsiaalministeeriumis valminud rahvastiku tervise arengukavast

Concerts & Opera

Index Scriptorium Estoniae

2006-01-01

Kammerorkestri Kremerata Baltica kontserdid: 19. apr. Londonis LSO St Lukesis, 21. apr. Oxfordis Sheldonian Theatre'is, 17. apr. Aldeburghis, 20. apr. Manchesteris Bridgewater Hallis, 23. apr. Wales Millennium Centre'is, 22. apr. Edinburghis Usher Hallis

Development of an amphibious robot for visual inspection of APR1400 Npp IRWST strainer

International Nuclear Information System (INIS)

Jang, You Hyun; Kim, Jong Seog

2014-01-01

An amphibious inspection robot system (hereafter AIROS) is being developed to visually inspect the in-containment refueling storage water tank (hereafter IRWST) strainer in APR1400 instead of a human diver. Four IRWST strainers are located in the IRWST, which is filled with boric acid water. Each strainer has 108 sub-assembly strainer fin modules that should be inspected with the VT-3 method according to Reg. guide 1.82 and the operation manual. AIROS has 6 thrusters for submarine voyage and 4 legs for walking on the top of the strainer. An inverse kinematic algorithm was implemented in the robot controller for exact walking on the top of the IRWST strainer. The IRWST strainer has several top cross braces that are extruded on the top of the strainer, which can be obstacles of walking on the strainer, to maintain the frame of the strainer. Therefore, a robot leg should arrive at the position beside the top cross brace. For this reason, we used an image processing technique to find the top cross brace in the sole camera image. The sole camera image is processed to find the existence of the top cross brace using the cross edge detection algorithm in real time. A 5-DOF robot arm that has multiple camera modules for simultaneous inspection of both sides can penetrate narrow gaps. For intuitive presentation of inspection results and for management of inspection data, inspection images are stored in the control PC with camera angles and positions to synthesize and merge the images. The synthesized images are then mapped in a 3D CAD model of the IRWST strainer with the location information. An IRWST strainer mock-up was fabricated to teach the robot arm scanning and gaiting. It is important to arrive at the designated position for inserting the robot arm into all of the gaps. Exact position control without anchor under the water is not easy. Therefore, we designed the multi leg robot for the role of anchoring and positioning. Quadruped robot design of installing sole

Development of an amphibious robot for visual inspection of APR1400 Npp IRWST strainer

Energy Technology Data Exchange (ETDEWEB)

Jang, You Hyun; Kim, Jong Seog [Korea Hydro Nuclear Power Central Research Institute, Daejeon (Korea, Republic of)

2014-06-15

An amphibious inspection robot system (hereafter AIROS) is being developed to visually inspect the in-containment refueling storage water tank (hereafter IRWST) strainer in APR1400 instead of a human diver. Four IRWST strainers are located in the IRWST, which is filled with boric acid water. Each strainer has 108 sub-assembly strainer fin modules that should be inspected with the VT-3 method according to Reg. guide 1.82 and the operation manual. AIROS has 6 thrusters for submarine voyage and 4 legs for walking on the top of the strainer. An inverse kinematic algorithm was implemented in the robot controller for exact walking on the top of the IRWST strainer. The IRWST strainer has several top cross braces that are extruded on the top of the strainer, which can be obstacles of walking on the strainer, to maintain the frame of the strainer. Therefore, a robot leg should arrive at the position beside the top cross brace. For this reason, we used an image processing technique to find the top cross brace in the sole camera image. The sole camera image is processed to find the existence of the top cross brace using the cross edge detection algorithm in real time. A 5-DOF robot arm that has multiple camera modules for simultaneous inspection of both sides can penetrate narrow gaps. For intuitive presentation of inspection results and for management of inspection data, inspection images are stored in the control PC with camera angles and positions to synthesize and merge the images. The synthesized images are then mapped in a 3D CAD model of the IRWST strainer with the location information. An IRWST strainer mock-up was fabricated to teach the robot arm scanning and gaiting. It is important to arrive at the designated position for inserting the robot arm into all of the gaps. Exact position control without anchor under the water is not easy. Therefore, we designed the multi leg robot for the role of anchoring and positioning. Quadruped robot design of installing sole

Vastutus Euroopa eest / Igor Gräzin

Index Scriptorium Estoniae

Gräzin, Igor, 1952-

2004-01-01

Ilmunud ka: Põhjarannik, 14. apr. 2004, lk. 2; Severnoje Poberezhje, 14. apr. 2004, lk. 2; Valgamaalane, 13. apr. 2004, lk. 2; Sakala, 13. apr. 2004, lk. 2; Hiiu Leht, 16. apr. 2004, lk. 2; Paremad Uudised, apr., nr. 4, 2004, lk. 7; Meie Maa, 22. apr. 2004, lk. 2; Harjumaa, 23. apr. 2004, lk. 2. Autor teeb kokkuvõtteid Eesti majanduse ja poliitilise struktuuri edukusest ning vaeb EL-ist tulevaid ebameeldivusi

Perekondade ühinemise eelnõust / Mart Nutt

Index Scriptorium Estoniae

Nutt, Mart, 1962-

2002-01-01

Ilmunud ka: Hiiumaa 1. apr. lk. 2, Meie Maa 13. apr. lk. 2, Põhjarannik, Severnoje Poberezhje 13. apr. lk. 2, Lääne-Harju Ekspress 13. apr. lk. 3, Lääne Elu, Vooremaa 16. apr. lk. 4;2, Molodjozh Estonii 18. apr. lk. 4, Sillamajeskii Vestnik : Notabene 18. apr. lk. 5, Valgamaalane 18. apr. lk. 2, Virumaa Teataja 30. apr. lk. 7. EL liikmeks saamisega kaasneb kohustus tagada turvalisus EL-i välispiiril ja viia ellu ühtset immigratsioonipoliitikat. Autor: Isamaaliit. Parlamendisaadik

Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.

Science.gov (United States)

Shalom-Feuerstein, Ruby; Serror, Laura; Aberdam, Edith; Müller, Franz-Josef; van Bokhoven, Hans; Wiman, Klas G; Zhou, Huiqing; Aberdam, Daniel; Petit, Isabelle

2013-02-05

Ectodermal dysplasia is a group of congenital syndromes affecting a variety of ectodermal derivatives. Among them, ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome is caused by single point mutations in the p63 gene, which controls epidermal development and homeostasis. Phenotypic defects of the EEC syndrome include skin defects and limbal stem-cell deficiency. In this study, we designed a unique cellular model that recapitulated major embryonic defects related to EEC. Fibroblasts from healthy donors and EEC patients carrying two different point mutations in the DNA binding domain of p63 were reprogrammed into induced pluripotent stem cell (iPSC) lines. EEC-iPSC from both patients showed early ectodermal commitment into K18(+) cells but failed to further differentiate into K14(+) cells (epidermis/limbus) or K3/K12(+) cells (corneal epithelium). APR-246 (PRIMA-1(MET)), a small compound that restores functionality of mutant p53 in human tumor cells, could revert corneal epithelial lineage commitment and reinstate a normal p63-related signaling pathway. This study illustrates the relevance of iPSC for p63 related disorders and paves the way for future therapy of EEC.

Haldusreform - mis ja milleks / Kalle Jürgenson

Index Scriptorium Estoniae

Jürgenson, Kalle, 1960-

2001-01-01

Riigi haldamise kolme tasandit - riigi keskvõimu, maakonna ja kohalike omavalitsuste tasandit - on vaja ühes või teises osas reformida. Autor: Isamaaliit. Parlamendisaadik. Ilmunud ka: Võrumaa Teataja, 10. apr. 2001, lk. 2; Põhjarannik, 10. apr. 2001, lk. 2; Severnoje Poberezhje, 10. apr. 2001, lk. 2; Meie Maa, 10. apr. 2001, lk. 2; Lääne Elu, 10. apr. 2001, lk. 4; Vooremaa, 10. apr. 2001, lk. 2; Nädaline, 10. apr. 2001, lk. 5; Virumaa Teataja, 18. apr. 2001, lk. 7; Infoleht : Isamaaliit, apr., nr. 27, 2001, lk. 8

Ühistransport kui ühiskonna peegel / Rudolf Tigasing

Index Scriptorium Estoniae

Tigasing, Rudolf

2007-01-01

Ilmunud ka: Sakala, 10. apr. 2007, lk. 2; Nädaline, 10. apr. 2007, lk. 4; Meie Maa, 20. apr. 2007, lk. 2; Vooremaa, 10. apr. 2007, lk. 2; Põhjarannik, 11. apr. 2007, lk. 2; Severnoje Poberezhje, 11. apr. 2007, lk. 2; Koit, 12. apr. 2007, lk. 6; Lääne Elu, 14. apr. 2007, lk. 2; Tartu Postimees, 16. apr. 2007, lk. 2; Pärnu Postimees, 5. mai 2007, lk. 19; Järva Teataja, 21. juuli 2007, lk. 2. Transpordi Ametiühingu bussijuhtide sektsiooni asejuhataja Eesti bussijuhtide olukorrast

Reha jalge all / Andrus Villem

Index Scriptorium Estoniae

Villem, Andrus

2004-01-01

Ilmunud ka: Vooremaa, 15. apr. 2004, lk. 2; Koit, 15. apr. 2004, lk. 6; Meie Maa, 14. apr. 2004, lk. 2; Sakala, 14. apr. 2004, lk. 2; Hiiu Leht, 16. apr. 2004, lk. 2; Harjumaa, 20. apr. 2004, lk. 2; Virumaa Teataja, 22. apr. 2004, lk. 7; Koit, 22. apr. 2004, lk. 2. Autor arutleb õiguskantsler Allar Jõksi tõstatatud küsimuse üle Riigikogu liikmete kuulumisest riigiettevõtete nõukogudesse

Abstract Résumé

African Journals Online (AJOL)

1 juil. 2013 ... VIH car ils facilitent l'acce`s a` la prévention et aux soins pour la personne avec ... plus général hypothétique en termes de prévention. La PVVIH ..... Scolarisation. Primaire. 2,7. 3. Secondaire. 87,4. 97. Supérieure. 9,9. 11.

Access to Norplant Removal: An Issue of Informed Choice | Tolley ...

African Journals Online (AJOL)

approbation de son mari à l'égard de la méthode utilisée ont augmenté son acceptation des effets secondaires et l'utilisation de la méthode. Le conseil que les femmes ont aperçu comme étant méticuleux y compris les discussions des autres ...

Leveillula taurica ON Ficus carica ABSTRACT RÉSUMÉ

African Journals Online (AJOL)

Prof. Adipala Ekwamu

Les conidiophores avaient des pattes à cellules cylindriques, munis d'une seule de conidium ou occasionnellement avec des chaînes courtes de 2-3 conidia. Les champignons avaient produit des conidia primaries à bout en forme de lance, ainsi que des conidia secondaires ellipsoides voire cylindriques. Les cléistothèces ...

Dictyostelium cells bind a secreted autocrine factor that represses cell proliferation

Directory of Open Access Journals (Sweden)

Phillips Jonathan E

2009-02-01

Full Text Available Abstract Background Dictyostelium cells secrete the proteins AprA and CfaD. Cells lacking either AprA or CfaD proliferate faster than wild type, while AprA or CfaD overexpressor cells proliferate slowly, indicating that AprA and CfaD are autocrine factors that repress proliferation. CfaD interacts with AprA and requires the presence of AprA to slow proliferation. To determine if CfaD is necessary for the ability of AprA to slow proliferation, whether AprA binds to cells, and if so whether the binding requires the presence of CfaD, we examined the binding and effect on proliferation of recombinant AprA. Results We find that the extracellular accumulation of AprA increases with cell density and reaches a concentration of 0.3 μg/ml near a stationary cell density. When added to wild-type or aprA- cells, recombinant AprA (rAprA significantly slows proliferation at 0.1 μg/ml and higher concentrations. From 4 to 64 μg/ml, the effect of rAprA is at a plateau, slowing but not stopping proliferation. The proliferation-inhibiting activity of rAprA is roughly the same as that of native AprA in conditioned growth medium. Proliferating aprA- cells show saturable binding of rAprA to 92,000 ± 11,000 cell-surface receptors with a KD of 0.03 ± 0.02 μg/ml. There appears to be one class of binding site, and no apparent cooperativity. Native AprA inhibits the binding of rAprA to aprA- cells with a Ki of 0.03 μg/ml, suggesting that the binding kinetics of rAprA are similar to those of native AprA. The proliferation of cells lacking CrlA, a cAMP receptor-like protein, or cells lacking CfaD are not affected by rAprA. Surprisingly, both cell types still bind rAprA. Conclusion Together, the data suggest that AprA functions as an autocrine proliferation-inhibiting factor by binding to cell surface receptors. Although AprA requires CfaD for activity, it does not require CfaD to bind to cells, suggesting the possibility that cells have an AprA receptor and a Cfa

Cancer du sein au Cameroun, profil histo-épidémiologique: à propos de 3044 cas

Science.gov (United States)

Engbang, Jean Paul Ndamba; Essome, Henri; Koh, Valère Mve; Simo, Godefroy; Essam, Jean Daniel Sime; Mouelle, Albert Sone; Essame, Jean Louis Oyono

2015-01-01

Décrire les caractéristiques épidémiologiques et histo-pathologiques des tumeurs malignes du sein au Cameroun. Il s'agissait d'une étude rétrospective descriptive portant sur les tumeurs malignes du sein, colligées, dans les registres des différents laboratoires d'Anatomie Pathologique publiques et privés repartis dans cinq régions (centre, littoral, Ouest, Nord-ouest, Sud-ouest), pendant une période de 10 ans (2004-2013). Les paramètres étudiés étaient la fréquence, l’âge, le sexe, la localisation, le type et le grade histologique, et les récepteurs hormonaux. Un total de 3044 cas de cancers du sein a été recensé, soit une fréquence annuelle de 304,4 cas en moyenne. Le sexe féminin était le plus représenté avec 2971 cas (97,60%) et les hommes avec 73 cas (2,40%), soit un sexe ratio (H/F) de 0,02. L’âge moyen des patients était de 46±15,87 ans, avec des extrêmes de 13 et 95 ans. Selon la localisation, le sein gauche était atteint dans 1244 cas (52%) et le sein droit dans 1115 cas (47%). Au plan histologique, on retrouvait essentiellement des carcinomes avec 96,50% des cas, des sarcomes 1,39%, des lymphomes 1,07% et la maladie de Paget du mamelon, 1,03%. Les tumeurs épithéliales étaient infiltrantes dans 2049 cas (84,46%), avec une prédominance du carcinome canalaire infiltrant (1870 cas) et non infiltrantes dans 377 cas (15,54%). Le grade histo-pronostic de SBR avait révélé une prédominance du grade II dans 66% des cas. Les cancers du sein restent une pathologie fréquente au Cameroun et atteignent principalement la population féminine en âge de procréer. Ils sont caractérisés par la prédominance du carcinome canalaire infiltrant. PMID:26523182

Identity of major sulfur-cycle prokaryotes in freshwater lake ecosystems revealed by a comprehensive phylogenetic study of the dissimilatory adenylylsulfate reductase.

Science.gov (United States)

Watanabe, Tomohiro; Kojima, Hisaya; Fukui, Manabu

2016-11-08

Adenylylsulfate reductase is a heterodimeric complex of two subunits, AprB and AprA, and is a key enzyme in dissimilatory sulfate reduction and sulfur oxidation. Common use of aprA as a functional marker gene has revealed the diversity of sulfur-cycle prokaryotes in diverse environments. In this study, we established a comprehensive sequence set of apr genes and employed it to reanalyze apr phylogeny, evaluate the coverage of a widely used primer set (AprA-1-FW/AprA-5-RV), and categorize environmental aprA sequences. Phylogenetic tree construction revealed new members of Apr lineage II and several previously unrecognized lateral gene transfer events. Using the established phylogenetic tree, we classified all previously reported aprA sequences amplified from freshwater lakes with the primer pair AprA-1-FW/AprA-5-RV in addition to the aprA sequences newly retrieved from freshwater lakes; the obtained results were complemented by 16S rRNA clone library analysis. Apr-based classifications of some of operational taxonomic units were supported by 16S rRNA-based analysis. This study updates our knowledge on the phylogeny of aprBA and shows the identities of several sulfur-cycle bacteria, which could not be classified to a known taxa until now. The established apr sequence set is publicly available and can be applied to assign environmental sequences to known lineages.

Eakatele suurem kaal omavalitsustes / Tunne Kelam

Index Scriptorium Estoniae

Kelam, Tunne, 1936-

2004-01-01

Ilmunud ka: Virumaa Teataja, 16. apr. 2004, lk. 7; Põhjarannik, 16. apr. 2004, lk. 2; Severnoje Poberezhje, 16. apr. 2004, lk. 2; Hiiumaa, 17. apr. 2004, lk. 2; Koit, 20. apr. 2004, lk. 6; Pärnu Postimees, 21. apr. 2004, lk. 15; Vali Uudised, 21. apr. 2004, lk. 2; Meie Maa, 21. apr. 2004, lk. 2; Videvik, 22. apr. 2004, lk. 3; Sakala, 11. mai 2004, lk. 2. Autori arvates tuleks lõpetada vabatahtliku pensionikindlustuse rahastamine esimese samba arvelt, samuti tuleb enam kaasata eakaid inimesi otsuste tegemise protsessi ja tagada neile suuremad võimalused kohaliku elu mõjutamiseks

Suhkrutrahvi maksku süüdlased / Eero Elenurm

Index Scriptorium Estoniae

Elenurm, Eero

2005-01-01

Ilmunud ka Pärnu Postimees 1. apr, lk. 15, Vali Uudised 1. apr. lk. 2, Põhjarannik 2. apr., lk. 2, Severnoje Poberezhje 2. apr., lk. 2, Valgamaalane 2. apr. lk. 2, Hiiu Leht, Võrumaa Teataja 5. apr., lk. 2, Koit 5. apr. lk. 2,6, Meie Maa 6. apr. lk. 2, Türi Rahvaleht 9. apr. lk. 4. Maksu- ja tolliameti tubli töö tulemusena ettevõtetest leitud deklareerimata suhkruvarud ei suurenda Eestile Euroopa Komisjonis määratud trahvisummat, vaid see võimaldab Eesti riigil osa trahvist sisse nõuda liigset suhkruvaru varjanud ettevõtetel

Vanasti oli parem / Paul-Eerik Rummo

Index Scriptorium Estoniae

Rummo, Paul-Eerik, 1942-

2002-01-01

Ilmunud ka: Hiiumaa, Koit, Lääne-Harju Ekspress, Pärnu Postimees 5. apr. lk. 2;6;3;2, Hiiu Leht 5. apr. lk. 2, Põhjarannik, Severnoje Poberezhje 5. apr. lk. 2, Vooremaa 9. apr. lk. 2, Nädaline, Valgamaalane, Lääne Elu 9. apr. lk. 2;2;4, Meie Maa 10. apr. lk. 2, Sakala 18. apr. lk. 2, Järva Teataja 20. apr. lk. 2, Paremad Uudised aprill nr. 4 lk. 7. Eesti erakonnapoliitikast. Autor: Reformierakond. Parlamendisaadik

Europinė semiotika šiandien | Sémiotique européenne d’aujourd’hui

Directory of Open Access Journals (Sweden)

Kęstutis Nastopka

2004-01-01

Full Text Available Dans le champ sémiotique, deux approches épistémologiques se distinguent : sémiotique européenne et sémiotique américaine. La sémiotique européenne, issue de la théorie du signe linguistique de Ferdinand de Saussure, dans les années 1960 voit se former deux écoles indépendantes : celle de Paris (de Greimas et celle de Tartou-Moscou (de Lotman.La sémiotique dite « standard » de Greimas présente une théorie du discours envisagé comme un tout de signification. En comprenant la signification comme un processus, Greimas décrit les transformations des significations d’après le modèle du discours mythique élaboré par Vladimir Propp. Le monde est traité comme discontinu et composé d’oppositions. Dans les années 1980 l’école greimassienne passe de la sémiotique de faire à celle d’état, de la discontinuité à la continuité, de l’objet au sujet, de l’énoncé à l’énonciation. Dans la sémiotique des passions au centre du programme narratif se trouve une compétence modale du sujet. Ces derniers temps, parmi les héritiers de Greimas, à côté de la sémiotique tensive qui choisit un métalangage savant et des schématisations un peu arides, apparaît une sémiotique esthésique, issue de De l’imperfection de Greimas.Le concept de systèmes modelants secondaires est devenu une sorte d’emblème de l’école de Tartou. Ce terme détermine des structures communicatives différentes, organisées d’après le modèle des signes linguistiques. A la recherche d’un métalangage scientifique, commun aux diverses disciplines humaines, on s’oriente vers la linguistique structurale et la théorie de l’information. Autour de l’année 1980, dans la sémiotique de Lotman la conception du texte commeune manifestation de la langue est changée par celle du texte qui produit sa propre langue. Le texte est considéré non plus comme un systéme autonome, synchronique mais comme un énoncé, inséparable de la m

Research

African Journals Online (AJOL)

ebutamanya

21 oct. 2015 ... pelvienne, les troubles de l'hémostase, les tumeurs vésicales, les rétentions vésicales par caillotage, l'absence de globe vésical. Matériels et équipements Pour la réalisation de cette CPC, ont été utilisés: une sonde de Foley charrière 16, 18 ou 20; une pince de Kelly droite ou courbe (sans griffe) de 14 ou ...

Case report

African Journals Online (AJOL)

raoul

22 avr. 2012 ... postérieur de la 6ème côte droite et arrivant jusqu´au contact de l´articulation costo-vertebrale (Figure 1). Comme la tumeur était bien circonscrite une intervention chirurgicale à visée diagnostique et thérapeutique était décidée. On avait réalisé alors une résection en mononbloc des arcs postérieurs des 5e ...