WorldWideScience

Sample records for tu devrais savoir

  1. Savoirs appris, savoirs réfléchis

    OpenAIRE

    Collomb, Natacha

    2014-01-01

    Ce numéro thématique fait suite au séminaire de l’IrAsia (alors IRSEA) « Savoirs locaux et constitution des savoirs en sciences humaines » que j’avais animé en 2010-2011 dans le cadre de l’axe de recherche éponyme dont Jean-Marc de Grave était alors coresponsable et dont il prolonge actuellement les réflexions dans le cadre de l’axe « Savoirs et patrimoines », thématique « Constitution et pérennisation des savoirs et des savoir-faire ». Les contributeurs (dont deux, Bénédicte Brac de la Perri...

  2. Reference Specifications for SAVOIR Avionics Elements

    Science.gov (United States)

    Hult, Torbjorn; Lindskog, Martin; Roques, Remi; Planche, Luc; Brunjes, Bernhard; Dellandrea, Brice; Terraillon, Jean-Loup

    2012-08-01

    Space industry and Agencies have been recognizing already for quite some time the need to raise the level of standardisation in the spacecraft avionics systems in order to increase efficiency and reduce development cost and schedule. This also includes the aspect of increasing competition in global space business, which is a challenge that European space companies are facing at all stages of involvement in the international markets.A number of initiatives towards this vision are driven both by the industry and ESA’s R&D programmes. However, today an intensified coordination of these activities is required in order to achieve the necessary synergy and to ensure they converge towards the shared vision. It has been proposed to federate these initiatives under the common Space Avionics Open Interface Architecture (SAVOIR) initiative. Within this initiative, the approach based on reference architectures and building blocks plays a key role.Following the principles outlined above, the overall goal of the SAVOIR is to establish a streamlined onboard architecture in order to standardize the development of avionics systems for space programmes. This reflects the need to increase efficiency and cost-effectiveness in the development process as well as account the trend towards more functionality implemented by the onboard building blocks, i.e. HW and SW components, and more complexity for the overall space mission objectives.

  3. QU’EST-CE QU’UN SAVOIR POPULAIRE ? TRANSMISSION POPULAIRE SAVANTE DES SAVOIRS NON ECRITS

    Directory of Open Access Journals (Sweden)

    Salim Mokaddem

    2014-12-01

    Full Text Available Les problèmes afférents à l’éducation et à la transmission sont très souvent confrontés à ceux de la trace et de la mémoire écrite ; la patrimonialisation des savoirs passe encore majoritairement par les voies classiques de la littéracie, du discours écrit et des systèmes académiques (curricula, diplômatures, concours, lettres de motivations, évaluations, etc.. Pourtant les savoirs oraux et les pratiques non discursives – au sens de l’oralité de transmission – sont autant formatrices et transmissives que les savoirs et les vérités formelles normées par des processus dont Foucault a analysé les ordres et les logiques spécifiques d’inclusion, d’exclusion, d’ordre, de normalisation et de production. Nous voudrions introduire un corps de réflexion à partir d'une histoire hétéromorphe à celle que l’Université prolonge et sanctifie par la consécration des savoirs écrits, homologués et reconnus dans les validations, le corpus qu'elle ritualise, la forme institutionnelle qu'elle impose, les textes qu’elle produit, autorise, interdit ou canonise, souvent en recourant à des types de souverainetés ou de reconnaissances légitimes récusant justement ce qui ne relève pas de son pouvoir propre.

  4. Savoir gérer le mal

    Directory of Open Access Journals (Sweden)

    Michel Maffesoli

    2015-09-01

    Full Text Available Le sens commun, conservatoire immémorial de la sagesse humaine « sait », de savoir incorporé, que le mal, l’ombre, la mort, la douleur sont des caractéristiques essentielles de l’existence en son entièreté. Dès lors les créatures quelles qu’elles soient, sont des manifestations de la vie et, dès lors, méritent une attitude « compassionnelle », fraternelle, parce qu’ensemble elles constituent le flux vital. C’est ainsi que l’on peut comprendre l’utilité sociale de ces divers « mondes intermédiaires » que sont les croyances, religieuses ou philosophiques, au « double », au « daimon », aux esprits et autres figures tutélaires ou effrayantes. Elles aident à vivre, au jour le jour, la souffrance en la communalisant.

  5. Tu voz, tu lugar: proyecto comunicacional

    OpenAIRE

    Machado, Karen Noemí; Mamani, Ileana Vanesa; Montoya, Ana Alejandra

    2015-01-01

    Tu voz, tu lugar” es un proyecto comunicacional realizado en el Centro de Actividades Juveniles (C.A.J) del Colegio Secundario Luis María Preti N°5171. Éste se encuentra vinculado a las cátedras Promoción Cultural Comunitaria y Residencia/Pasantía en el Ámbito de la Promoción Comunitaria de la carrera Tecnicatura en Comunicación Social- UNSa- Sede Tartagal. Este proyecto es el resultado de un diagnostico comunicacional, que se retomó desde un posicionamiento teórico crítico, con el...

  6. Tu proyecto de vida

    OpenAIRE

    Ramos, Georgina

    2012-01-01

    - Párrafo Inicial - Conociendo a Liliana N. - La intervención de la psicóloga Adriana - Tu proyecto de vida - Referencias - Notas de enseñanza o Resumen o Objetivos o Temas relacionados o Plan de aplicación para el aprendizaje o Análisis o Epílogo

  7. Core TuLiP

    NARCIS (Netherlands)

    Czenko, M.R.; Etalle, Sandro

    2007-01-01

    We propose CoreTuLiP - the core of a trust management language based on Logic Programming. CoreTuLiP is based on a subset of moded logic programming, but enjoys the features of TM languages such as RT; in particular clauses are issued by different authorities and stored in a distributed manner. We

  8. SECTION 4 : BUDGET Remarque : Pour en savoir plus sur les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    (anonymous)

    SECTION 4 : BUDGET. Remarque : Pour en savoir plus sur les restrictions budgétaires, consulter l'appel à propositions et la foire aux questions. Inscrire toutes les sommes en dollars canadiens. 4.1 Indiquez toutes les dépenses prévues (en CAD). Inscrire une valeur numérique sans caractères, ni espaces, ni virgules (p. ex ...

  9. Mobiliser le savoir pour éradiquer la faim

    OpenAIRE

    Serageldin, Ismail

    2013-01-01

    Leçon inaugurale prononcée le 18 novembre 2010 Chaire Savoirs contre pauvreté Aujourd’hui, près d’un milliard de personnes dans le monde souffrent de la faim. Nous disposons pourtant des moyens techniques et scientifiques pour lutter contre ce fléau. Acteur international majeur des politiques de lutte contre la pauvreté depuis plusieurs décennies, Ismail Serageldin expose ici les causes de la faim, la question de la sécurité alimentaire et la nécessité de transformer l’agriculture mondiale. ...

  10. Comment diffuser les savoirs à travers les Alpes ?

    Directory of Open Access Journals (Sweden)

    Wolfgang Pfefferkorn

    2009-03-01

    Full Text Available CIPRA’s Future in the Alps Project aims at showcasing examples of successful implementation and successful projects in the Alps, and making available to others the extensive pool of experience and practical knowledge that lies in these projects. But how to transfer knowledge in an area of some 14 million inhabitants with several linguistic and cultural regions in which thousands of projects are carried out each year, that all kinds of players who work and life in completely different contexts are able to learn and benefit from one another? How do you go about something like that?Le projet « Avenir dans les Alpes » de la CIPRA (Commission Internationale pour la Protection des Alpes a pour objectif de présenter des exemples de réalisations et de projets réussis dans les Alpes, et de mettre à disposition du public l’ensemble de l’expérience et des connaissances pratiques acquises dans le cadre de ces projets. Cependant, comment transférer les savoirs dans une zone comptant quelque 14 millions d’habitants, composée de plusieurs régions linguistiques et culturelles dans lesquelles des milliers de projets sont menés à bien chaque année, et dont tous les acteurs, qui travaillent et vivent dans des contextes complètement différents, sont capables d’apprendre et de tirer profit les uns des autres ? Comment aborder ce genre de cas ?

  11. OECI TuBaFrost tumor biobanking

    NARCIS (Netherlands)

    Riegman, Peter H. J.; Bosch, Antonio Llombart; Riegman, P. H. J.; Dinjens, W. N. M.; Oomen, M. H. A.; Spatz, A.; Ratcliffe, C.; Knox, K.; Mager, R.; Kerr, D.; Pezzella, F.; van Damme, B.; van de Vijver, M.; van Boven, H.; Morente, M. M.; Alonso, S.; Kerjaschki, D.; Pammer, J.; Lopez-Guerrero, J. A.; Bosch, A. Llombart; Carbone, A.; Gloghini, A.; Teodorovic, I.; Isabelle, M.; Jaminé, D.; Passioukov, A.; Lejeune, S.; Therasse, P.; van Veen, E. B.; Lam, K. H.; Oosterhuis, J. W.

    2008-01-01

    OECI TuBaFrost harbors a complete infrastructure for the exchange of frozen tumor samples between European countries. OECI TuBaFrost consists of: * A code of conduct on how to exchange human residual samples in Europe, * A central database application accessible over the Internet (www.tubafrost.org)

  12. Mobiliser les externalités de savoir au service de développement local

    Directory of Open Access Journals (Sweden)

    Jean Bouinot

    2007-03-01

    Full Text Available Introduction : un processus invisible mais efficace Les externalités de savoir représentent des transferts de savoir gratuits d’un territoire à un autre (villes, régions, … : i.e. une ville (i bénéficie des effets de R&D et / ou des activités innovantes d’une autre ville (j « sans bourse délier ». Le savoir qui nous intéressera ici sera celui qui « féconde » la R&D et des innovations marchandes (dépôt de brevets. Ce processus de « spillover » de (j vers (2 fait tout d’abord l’objet d’un...

  13. TU electric reactor model verification

    International Nuclear Information System (INIS)

    Willingham, C.E.; Killgore, M.R.

    1989-01-01

    Power reactor benchmark calculations using the code package CASMO-3/SIMULATE-3 have been performed for six cycles of Prairie Island Unit 1. The reload fuel designs for the selected cycles include gadolinia as a burnable absorber, natural uranium axial blankets, and increased water-to-fuel ratio. The calculated results for both low-power physics tests (boron end points, control rod worths, and isothermal temperature coefficients) and full-power operation (power distributions and boron letdown) are compared to measured plant data. These comparisons show that the TU Electric reactor physics models accurately predict important physics parameters for power reactors

  14. Power Matters: Foucault's "Pouvoir/Savoir" as a Conceptual Lens in Information Research and Practice

    Science.gov (United States)

    Olsson, Michael; Heizmann, Helena

    2015-01-01

    Introduction: This paper advocates Foucault's notion of pouvoir/savoir (power/knowledge) as a conceptual lens that information researchers might fruitfully use to develop a richer understanding of the relationship between knowledge and power. Methods: Three of the authors' earlier studies are employed to illustrate the use of this conceptual lens.…

  15. Combler l'écart entre la recherche et le savoir | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    7 janv. 2011 ... Il ne sera jamais facile de comprendre une réalité dans toute sa complexité, mais tenter de le faire en associant le savoir local à celui des spécialistes accroît certainement les chances de réussite.

  16. Droits d'auteur et accès au savoir en Afrique | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    incidence de celles-ci est loin de faire l'unanimité. La question de l'équilibre entre la protection des intérêts des producteurs et l'accès aux produits du savoir, comme le matériel didactique, inquiète particulièrement les pays en développement.

  17. Savoir traditionnel sur les plantes antipaludiques à propriétés ...

    African Journals Online (AJOL)

    Savoir traditionnel sur les plantes antipaludiques à propriétés analgésiques, utilisées dans le district de Bamako (Mali). A Dénou, K Koudouvo, A Togola, M Haïdara, S.M Dembélé, F.N. Ballo, R Sanogo, D Diallo, M Gbeassor ...

  18. One-step purification of E. coli elongation factor Tu

    DEFF Research Database (Denmark)

    Knudsen, Charlotte Rohde; Clark, Brian F. C.; Degn, B

    1993-01-01

    The tuf A gene, encoding the E. coli elongation factor Tu, was cloned in the pGEX gene fusion system. Upon expression EF-Tu is fused to glutathione-S-transferase serving as a purification handle with affinity for glutathione immobilised on agarose. This allows purification of EF-Tu in a one...

  19. Exploitation du savoir autochtone afin de créer des emplois pour les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Transformer l'emploi des femmes. L'étude explorera le potentiel d'approches novatrices locales ou autochtones visant à appuyer l'emploi en milieu rural. Les chercheurs auront recours à des méthodes quantitatives et qualitatives pour analyser la façon dont le savoir autochtone et la technologie peuvent être utilisés pour ...

  20. Le savoir au service de la démocratie du Myanmar | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En coopération avec d'autres partenaires du développement, le savoir au service de la démocratie du Myanmar s'appuiera sur plusieurs méthodes pour atteindre ces objectifs : Établir une capacité institutionnelle grâce à la formation et au mentorat des principales parties prenantes avec : l'offre de petites bourses de ...

  1. Liens entre le savoir et l'innovation dans les services de gestion des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Liens entre le savoir et l'innovation dans les services de gestion des déchets solides de trois municipalités du Sri Lanka. Ce projet de recherche-action portera sur l'innovation dans la prestation de services par les administrations locales au Sri Lanka. Il ciblera principalement les administrateurs locaux chargés de la ...

  2. Savoir faire plus le français à l'Université

    CERN Document Server

    Enjelvin, Géraldine

    2013-01-01

    Written by an experienced tutor, Savoir-Faire Plus is specifically designed to meet the requirements of today's generation of language undergraduates. Focusing on the life of an Anglophone first year undergraduate studying French in the UK and sharing a house with four francophone students, this engaging textbook provides:a clear, logical structurea blend of communicative, research-based and traditional exercisesa wide range of activities covering the four key linguistic skills as well as intercultural skillsauthentic texts (w

  3. Élargir la portée de notre savoir : Rapport annuel du programme ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Pour atteindre son objectif premier – renforcer les capacités d'adaptation en Afrique –, le programme ACCA s'appuie sur une stratégie de recherche-action participative, de renforcement des capacités et de partage du savoir. ... Il risque de ne pas suffire, vu le rythme et l'ampleur du réchauffement planétaire annoncé.

  4. TU Delft Library as a vital link

    NARCIS (Netherlands)

    Van Wezenbeek, W.J.S.M.

    2012-01-01

    The next step is to make the Library Learning Centre a vibrant part of the university campus. A university is by nature a learning and research centre. The university campus of the TU Delft is close to the city of Delft at one side, and Science Port Holland – Technopolis, at the other side. The

  5. Artemisinin and Chinese Medicine as Tu Science.

    Science.gov (United States)

    Fu, Jia-Chen

    2017-09-01

    The story of discovery of artemisinin highlights the diversity of scientific values across time and space. Resituating artemisinin research within a broader temporal framework allows us to understand how Chinese drugs like qinghao came to articulate a space for scientific experimentation and innovation through its embodiment of alternating clusters of meanings associated with tu and yang within scientific discourse. Tu science, which was associated with terms like native, Chinese, local, rustic, mass, and crude, articulated a radical vision of science in the service of socialist revolutionary ideals. Yang science, which signified foreign, Western, elite, and professional, tended to bear the hallmarks of professionalism, transnational networks in education and training, and an emphasis on basic or foundational research. With respect to medical research, the case of artemisinin highlights how the constitution of socialist science as an interplay of tu and yang engendered different scientific values and parameters for scientific endeavor. Modern medical research in Maoist China could harness the productive energies of mass participation to technical expertise in its investigations of Chinese drugs, and under the banner of tu science, it became possible and scientifically legitimate to research Chinese drugs in ways that had previously provoked resistance and controversy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. 1-concave basis for TU games

    NARCIS (Netherlands)

    Driessen, Theo; Khmelnitskaya, Anna Borisovna; Sales, J.

    2005-01-01

    The first stage of research, twenty years ago, on the subclass of 1-convex TU games dealt with its characterization through some regular core structure. Appealing abstract and practical examples of 1-convex games were missing until now. Both drawbacks are solved. On the one hand, a generating set

  7. Structural studies of EF-Tu complexes

    DEFF Research Database (Denmark)

    Johansen, Jesper Sanderhoff

    2011-01-01

    Protein synthesis is a process vital to all living organisms. Protein synthesis occurs on large ribonucleoprotein complexes called ribosomes. Amino acids (aa) are brought to the ribosome as part of a ternary complex consisting of elongation factor EF-Tu, GTP and aminoacyl-tRNA (aa-tRNA). The GTP...... elongation factor, EF-Ts, catalyse the dissociation of GDP from EF-Tu which in turn allows EF-Tu to bind another GTP molecule. The resulting EF-Tu:GTP complex is then cable of forming a ternary complex with a new aa-tRNA which can then associate with the ribosome. During my time as a Ph. D. student I have...... proteins and 22 tRNAs and 2 rRNAs. The mammalian mitochondria have their own specialised translational system for maintaining the synthesis of the 13 proteins. The mammalian mitochondrial protein synthesis resembles the prokaryotic system more than the cytosolic system from eukaryotes. Some of the t...

  8. Savoirs disciplinaires scolaires et savoirs de sens commun ou pourquoi des « idées vraies » ne prennent pas, tandis que des « idées fausses » ont la vie dure

    Directory of Open Access Journals (Sweden)

    David Lefrançois

    2011-05-01

    Full Text Available Les savoirs de sens commun sont solidement ancrés dans les usages, notamment grâce à l’habitude et à la sécurité ontologique qu’ils engendrent. Cet article examinera d’abord pourquoi les savoirs disciplinaires appris à l’école ne sont pas automatiquement réinvestis dans des contextes de nature extrascolaire et pourquoi les savoirs de sens commun résistent à leur déconstruction. La première partie de l’analyse sera marquée par le croisement de discours épistémologiques concernant la nature et la place des savoirs de sens commun dans les conceptions familières de la science. Cet article explorera ensuite les dynamiques qui marquent les relations qu’entretiennent les savoirs disciplinaires scolaires et les savoirs de sens commun en contexte scolaire. Le langage propre à la seconde partie se rattachera davantage aux débats en éducation sur l’importance prépondérante des savoirs de sens commun dans l’apprentissage disciplinaire par concepts. Enfin, nous montrerons qu’il existe des stratégies d’enseignement qui peuvent optimiser l’appropriation intellectuelle des savoirs disciplinaires scolaires et leur transfert dans les interactions quotidiennes.Common sense knowledge is firmly anchored in everyday practices, notably as a result of habit and also for the ontological security it provides. This article will first examine why disciplinary knowledge learned in school is not automatically reinvested in non-school contexts, as well as why common sense knowledge persists in the face of its own deconstruction. The first part of this analysis juxtaposes various epistemological discourses relating to the nature of common sense knowledge and its position in familiar conceptions of science. The article then explores how disciplinary knowledge taught in school and common sense knowledge interact in an educational context. This section of the article will focus mainly on educational debates pertaining to the

  9. Construction de savoirs professionnels dans une formation hybride : étude d’un carnet de bord en ligne collaboratif

    Directory of Open Access Journals (Sweden)

    Fatiha TALI

    2017-01-01

    Full Text Available Cet article se focalise sur la co-construction de savoirs professionnels, la nature de ces savoirs et les processus sous-jacents à cette construction dans un contexte de formation hybride à l’Université. Nous analysons les écrits dans le carnet de bord collaboratif en ligne d’un groupe d’enseignants interagissant et échangeant leurs expériences. L’analyse longitudinale montre une diversification des savoirs co-construits et mis en œuvre par les apprenants. Les interactions relevées indiquent : l’importance des échanges socio-affectifs; un étayage entre pairs visant l’enrôlement et le contrôle de la frustration; et de nombreux exemples pouvant servir à l’apprentissage vicariant.

  10. Dispositif pédagogique pour un apprentissage de savoir-faire

    Directory of Open Access Journals (Sweden)

    Bénédicte Talon

    2008-01-01

    Full Text Available Les travaux présentés ici concernent la conception d’un dispositif pédagogique destiné à la formation professionnelle dans l’enseignement supérieur. Notre intérêt se porte sur la pédagogie de groupe par projet pour favoriser l’apprentissage des savoirs et savoir-faire essentiels à l’exercice d’une activité professionnelle. Nous avons conçu un dispositif pédagogique, appelé «e-mallette MAETIC», support de cet apprentissage. Dans cet article, nous présentons le contexte scientifique de nos travaux, la genèse du dispositif et le modèle pédagogique en couches proposé. Nous exposons ensuite la méthode pédagogique MAETIC, la e-mallette développée en 2006, son expérimentation et, enfin, la e-mallette développée en 2007. Nous concluons par les perspectives de développement du dispositif ouvertes à ce jour.

  11. Accès au savoir en Afrique australe : le libre accès à la recherche à l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Access to Knowledge Southern Africa (A2KSA) a pour but de mieux comprendre les différentes contraintes entourant l'accès des universités d'Afrique australe au savoir à des fins de recherche et ... A new website and resource library will help improve developing country registration and information systems for vital events.

  12. Core TuLiP - Logic Programming for Trust Management

    NARCIS (Netherlands)

    Czenko, M.R.; Etalle, Sandro; Dahl, V.; Niemelä, I.

    2007-01-01

    We propose CoreTuLiP - the core of a trust management language based on Logic Programming. CoreTuLiP is based on a subset of moded logic programming, but enjoys the features of TM languages such as RT; in particular clauses are issued by different authorities and stored in a distributed manner. We

  13. Bertillonnage : savoirs, technologies, pratiques et diffusion internationale de l’identification judiciaire

    Directory of Open Access Journals (Sweden)

    Pierre Piazza

    2011-04-01

    Full Text Available Lors de la mise en ligne de la première version du Projet Bertillon et l’identification des personnes, 1880-1914 sur Criminocorpus en mars 2010, un appel à contributions avait été lancé en vue d’approfondir l’étude du Bertillonnage et des différents enjeux qui s’y rattachent à travers la publication d’articles scientifiques inédits. Trois thématiques à explorer avaient alors été privilégiées : la diffusion internationale de l’identification judiciaire ; les réseaux de savoir et les technologi...

  14. Savoirs et pratiques diététiques au Moyen Âge

    OpenAIRE

    Nicoud, Marilyn

    2009-01-01

    L’appartenance de la diététique au domaine de compétence du praticien médiéval est affirmée par nombre d’ouvrages utilisés pour l’enseignement de la médecine, à commencer par le Canon d’Avicenne, véritable somme du savoir médical, traduit en latin à Tolède au XIIe siècle par Gérard de Crémone. Avicenne y rappelle que la médecine est divisée en deux branches : l’une est dite théorique (car elle a pour finalité la connaissance des causes de la santé et de la maladie) ; l’autre pratique – et ell...

  15. Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

    DEFF Research Database (Denmark)

    Villa, Elizabeth; Sengupta, Jayati; Trabuco, Leonard G.

    2009-01-01

    of EF-Tu that trigger hydrolysis of GTP, along with key interactions, including those between the sarcin-ricin loop and the P loop of EF-Tu, and between the effector loop of EF-Tu and a conserved region of the 16S rRNA. Our data suggest that GTP hydrolysis on EF-Tu is controlled through a hydrophobic...

  16. L'accès au savoir en Afrique : Le rôle du droit d'auteur | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 déc. 2011 ... Même ceux qui se considèrent experts en matière de propriété intellectuelle tireront un immense profit de la lecture de ce livre et, plus largement, des travaux du projet Droit d'auteur et accès au savoir en Afrique. Sisule Musungu, Président de IQsensato, Genève. L'émergence d'Internet et de l'univers ...

  17. Accès au savoir en Afrique australe : le libre accès à la recherche à l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Access to Knowledge Southern Africa (A2KSA) a pour but de mieux comprendre les différentes contraintes entourant l'accès des universités d'Afrique australe au savoir à des fins de recherche et d'enseignement. ... Le CRDI offre un appui essentiel à la recherche en santé mondiale au Moyen-Orient et en Afrique du Nord.

  18. Accès au savoir en Afrique australe : le libre accès à la recherche à l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le projet, une collaboration de recherche entre la Southern African Regional Universities Association (SARUA) et le LINK Centre, permettra d'explorer les possibilités de créer un réseau régional de libre accès fondé sur une charte du savoir libre. A2KSA examinera comment diverses approches de libre accès aux travaux ...

  19. L'innovation au service d'économies du savoir caractérisées par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'innovation au service d'économies du savoir caractérisées par l'inclusion en Asie - phase II. Learning Initiatives for Network Economies in Asia (LIRNEasia) cherche à cerner les obstacles institutionnels à l'utilisation efficace des technologies de l'information et de la communication (TIC) pour améliorer les conditions de ...

  20. L'accès au savoir en Afrique : Le rôle du droit d'auteur | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 déc. 2011 ... L'ouvrage s'inspire des travaux du projet Droit d'auteur et accès au savoir en Afrique (D2ASA), un réseau de recherche lancé vers la fin de 2007 qui réunit des ... L'Initiative des conseils subventionnaires de la recherche scientifique en Afrique subsaharienne remporte le prix de la diplomatie scientifique.

  1. Characterization of Elongation Factor Tu of Mycoplasma ovipneumoniae

    Directory of Open Access Journals (Sweden)

    Xuan Zhang, Yue-feng Chu, Ping Zhao, Peng-cheng Gao, Ying He, Nu Wang and Zhong-xin Lu*

    2013-11-01

    Full Text Available Mycoplasma ovipneumoniae is considered as an important pathogen of small ruminants, but its antigenic proteins are not well known so far. In this study, we cloned the EF-Tu gene of M. ovipneumoniae and analyzed the molecular features of the gene and its coding protein for the first time. The gene was then expressed in E.coli and the antigenicity of the coding protein was evaluated as well. The EF-Tu gene of M. ovipneumoniae is 1209 bp in length, encodes 402 amino acids, and shares the highest DNA sequence identity of 87.5% and deduced amino acid sequence identity of 97.8% with those of M. hyopneumoniae, respectively. The recombinant EF-Tu protein can react with the polyclonal antiserum of M. ovipneumoniae and can induce humoral immune responses in mice, which indicated that the EF-Tu may be used as a candidate protein in developing the technologies to control the disease.

  2. Rejouer les savoirs anthropologiques: de durkheim aux aborigènes

    Directory of Open Access Journals (Sweden)

    Barbara Glowczewski

    2014-06-01

    Full Text Available Les formes élémentaires de la vie religieuse de Durkheim (2013 s'appuient essentiellement sur les observations et analyses de Spencer et Gillen (1899 des rituels d'Australie centrale. Découlant de 35 ans de recherches en Australie, l'article montre que le paradigme du XXe siècle a empêché Durkheim de voir l'importance du rapport à la terre dans la cosmologie et les pratiques rituelles des Aborigènes. Il a aussi ignoré le dynamisme réticulaire de leurs cartographies totémiques que, depuis la colonisation, ils continuent à réactualiser par l'art et les luttes sociales. La réappropriation indigène par la parole et d'autres expressions de leurs propres systèmes de savoir pose la question de la légitimité contemporaine des interprétations anciennes. Patrimonialisés, Durkheim et d'autres deviennent des mythes fondateurs des sciences sociales qui s'opposent parfois à la reconnaissance des peuples concernés. L'anthropologie est ainsi confrontée à un problème à la fois éthique et politique.

  3. Les Nobel juifs de chimie le partage du savoir au XX siècle

    CERN Document Server

    Benguigui, Isaac

    2010-01-01

    L'un des traits marquants et remarquables des Juifs tout au long de leur histoire, plusieurs fois millénaire, a été leur créativité dans tous les domaines, en particulier dans le domaine scientifique. Ils ont participé de façon impressionnante à la remise en cause des valeurs, au démantèlement des dogmes et à l'irruption des forces cachées. On peut d'emblée souligner que la contribution des Juifs à la science a été sans commune mesure avec le pourcentage de la population qu'ils représentent. Cela reste vrai pour la chimie du XXe siècle. A travers la vie et l'oeuvre de 23 prix Nobel de chimie, l'auteur nous livre une histoire passionnante de ces hommes, biens souvent des exilés et d'origine modeste. dont la science fut leur vocation et le partage du savoir leur crédo.

  4. Bouvard et Pécuchet et le savoir médical

    Directory of Open Access Journals (Sweden)

    Norioki Sugaya

    2009-01-01

    Full Text Available Le présent article a pour objet le dossier médical que Flaubert a constitué pour la préparation du chapitre III de Bouvard et Pécuchet. Ce dossier considérable, qui contient des notes de lecture prises par le romancier en vue de la rédaction du chapitre médical, nous permet de comprendre à quel point le « comique d’idées » propre au roman encyclopédique est le produit d’un travail intense sur le savoir. L’écriture romanesque de Bouvard explore en effet les configurations épistémologiques de chaque discipline, et met au jour surtout ses apories et ses insuffisances. Nous nous proposons donc d’aborder le dossier médical pour saisir le sens de l’excès documentaire pour l’esthétique flaubertienne. Notre étude se compose de trois parties. D’abord, nous étudierons la composition du dossier en nous demandant quels ouvrages médicaux a lu l’auteur de Bouvard. Ensuite, nous essaierons d’examiner le travail critique de Flaubert pratiqué sur les discours du savoir, en particulier la manière dont il traque et construit des contradictions. Enfin, nous analyserons un épisode du roman, celui de la fièvre typhoïde de Gouy, dont l’étude de la genèse nous montrera l’inscription de l’épistémologique dans la représentation romanesque.This article proposes to study the medical documents gathered by Flaubert for the preparation of Chapter III of Bouvart et Pécuchet. This substantial file, which contains reading notes taken by the novelist for the writing of the medical chapter, allows us to understand to what extent the “comic of ideas”, characteristic of the encyclopedic novel, is the result of an intensive work on knowledge. Indeed, the novelistic writing of Bouvard explores the epistemological configurations of each discipline, and in particular reveals its aporia and its insufficiencies. We have chosen to focus on the medical file in order to understand the meaning of the documentary excess with

  5. Studies of elongation factor Tu in Streptococcus faecium (ATCC 9790)

    Energy Technology Data Exchange (ETDEWEB)

    Bourbeau, P.P.

    1986-01-01

    It has been known for over twenty years that elongation factor Tu (Ef-Tu) is one of the proteins involved in protein synthesis in bacteria. Several years ago, it was proposed that Ef-Tu may, in addition, have other structural functions in bacterial. The author's research has examined the function of Ef-Tu in Streptococcus faecium. Using an antibiotic kirromycin, which specifically inhibits Ef-Tu function, the effects upon a number of cellular parameters were determined. Inhibition of both protein and RNA synthesis was found to be similar to the effect of chloramphenicol. Using the residual division technique for the determination of cell cycle events with both heterogeneous and sucrose gradient fractionated cell populations, a kirromycin sensitive event was detected between 8 min. (Td = 30 min.) and 19 min. (Td = 175 min.) later in the cell cycle than the chloramphenical sensitive event. This suggests that kirromycin is inhibiting a terminal cell cycle event which is in addition to the inhibition of protein synthesis. Purification of Ef-Tu was performed using two different methods: ion exchange and molecular exclusion chromatography; and GDP affinity chromatography. Various schemes were employed to try and obtain optimum cellular fractionation, allowing for both proper separation of ribosomes from the other cellular fractions and retention of enzymatic activity by Ef-Tu as determined by a /sup 3/H-GDP binding assay. Analysis of the cell cycle of S. faecium using the residual division technique was also performed. In addition, certain cell wall antibiotics were used to determine if other cell cycle events could be determined using the residual division technique.

  6. UNITÉS DE CONSERVATION, PLANIFICATION, DIALOGUE DE SAVOIRS E L’EDUCATION

    Directory of Open Access Journals (Sweden)

    Mario Alberto dos Santos

    2009-03-01

    Full Text Available Cette étude sur la planification en aires de protection environnementale d’usage durable a comme espace d’expérience vécue la réserve extrativiste marine baie d’Iguape – BA. Avec des réflexions sur l’importance de l’éducation et du dialogue de savoirs à la lumière des phénoménologies existentielle et de l’imagination, de la théorie systémique et de la science de la cognition, sera discuté et analysé, à partir de la réalité d’une aire de protection environnementale, la nécessité de la dialogicité et du caractère communautaire et leurs implications en actions et projets politiques tournés vers le développement social et humain. Les populations traditionnelles et leurs savboirs ne sont pas objets d’étude ; ils en sont les sujets et leur univers cognitif qui es essentiel à la planification tout comme les sciences. Cet article essaye de contribuer aux questions qui engagent la discussion de la conservation de la nature et les stratégies adéquates pour sa matérialisation : une organisation sociale et politique viable pour penser l’autonomie politique et économie et la liverté sociale de la population de la réserve extrativiste.

  7. College via iTunes U : TU Delft deelt graag kennis

    NARCIS (Netherlands)

    Suijker, P.

    2010-01-01

    De TU Delft publiceert lezingen, colleges en informatieve films op iTunes U van Apple. De auteur beschrijft waarom de TU Delft gekozen heeft voor iTunes U en op welke manier het project tot stand is gekomen.

  8. TU PATERE LEGEM QUAM IPSE FECISTI

    CERN Multimedia

    Association du personnel

    2010-01-01

    In two judgments of February 2009, the ILO Administrative Tribunal (hereafter ILOAT) upheld CERN’s contract policy. In another case having given rise to a recent judgment (3 February 2010), the same problems, in essence, were raised concerning the illegal injustice which could result from the implementation of the policy in question. This time, the Tribunal decided in favour of our colleague, basing itself on the Latin maxim tu patere legem quam ipse fecisti, according to which any authority is bound by its own rules, as long as such rules have not been amended or abrogated. In fact, the Administration had informed the complainant that his application for a long-term contract would be examined for six slots, when in fact it was examined for only one. This judgment represents a victory for the complainant, for the Staff Association and its perseverance, and also for the principle according to which any organisation must keep its word and act in good faith. It shows that, without reversing its jud...

  9. Trust Management in P2P systems using Standard TuLiP

    NARCIS (Netherlands)

    Czenko, M.R.; Doumen, J.M.; Etalle, Sandro

    2008-01-01

    In this paper we introduce Standard TuLiP - a new logic based Trust Management system. In Standard TuLiP, security decisions are based on security credentials, which can be issued by different entities and stored at different locations. Standard TuLiP directly supports the distributed credential

  10. Trust Management in P2P Systems Using Standard TuLiP

    NARCIS (Netherlands)

    Czenko, M.R.; Doumen, J.M.; Etalle, Sandro

    2008-01-01

    In this paper we introduce Standard TuLiP - a new logic based Trust Management system. In Standard TuLiP, security decisions are based on security credentials, which can be issued by different entities and stored at different locations. Standard TuLiP directly supports the distributed credential

  11. Savoirs locaux et apprentissage du partenariat dans la gestion des écosystèmes forestiers humides au Cameroun

    OpenAIRE

    Bidzanga Nomo, L.; Kalms, Jean-Marie; Havard, Michel; Njoya, Aboubakar

    2011-01-01

    Les écosystèmes forestiers humides du Cameroun subissent une pression accrue sur les ressources forestières et sur la terre liée à l'augmentation rapide de la population. Les agriculteurs s'adaptent en mobilisant leurs savoirs et développant des pratiques innovantes de gestion des écosystèmes forestiers dont la durabilité est mise en cause. Pour accompagner les agriculteurs dans ces évolutions, l'Association pour le développement des exploitations agricoles du centre (ADEAC) au Cameroun, en p...

  12. Problem-Centered Design and Personal Teaching Style: An Exploratory Study of Youguang Tu's Course on Philosophy of Education

    Science.gov (United States)

    Lei, Hongde

    2016-01-01

    Youguang Tu is a contemporary Chinese philosopher of education. His course on philosophy of education had a significant impact on his students. This exploratory study examines how Tu designed and taught this course. Ultimately, there are two reasons why Tu's course had such a significant influence on his students. The first is that Tu used…

  13. Elongation Factor-Tu (EF-Tu) proteins structural stability and bioinformatics in ancestral gene reconstruction

    Science.gov (United States)

    Dehipawala, Sunil; Nguyen, A.; Tremberger, G.; Cheung, E.; Schneider, P.; Lieberman, D.; Holden, T.; Cheung, T.

    2013-09-01

    A paleo-experimental evolution report on elongation factor EF-Tu structural stability results has provided an opportunity to rewind the tape of life using the ancestral protein sequence reconstruction modeling approach; consistent with the book of life dogma in current biology and being an important component in the astrobiology community. Fractal dimension via the Higuchi fractal method and Shannon entropy of the DNA sequence classification could be used in a diagram that serves as a simple summary. Results from biomedical gene research provide examples on the diagram methodology. Comparisons between biomedical genes such as EEF2 (elongation factor 2 human, mouse, etc), WDR85 in epigenetics, HAR1 in human specificity, DLG1 in cognitive skill, and HLA-C in mosquito bite immunology with EF Tu DNA sequences have accounted for the reported circular dichroism thermo-stability data systematically; the results also infer a relatively less volatility geologic time period from 2 to 3 Gyr from adaptation viewpoint. Comparison to Thermotoga maritima MSB8 and Psychrobacter shows that Thermus thermophilus HB8 EF-Tu calibration sequence could be an outlier, consistent with free energy calculation by NUPACK. Diagram methodology allows computer simulation studies and HAR1 shows about 0.5% probability from chimp to human in terms of diagram location, and SNP simulation results such as amoebic meningoencephalitis NAF1 suggest correlation. Extensions to the studies of the translation and transcription elongation factor sequences in Megavirus Chiliensis, Megavirus Lba and Pandoravirus show that the studied Pandoravirus sequence could be an outlier with the highest fractal dimension and lowest entropy, as compared to chicken as a deviant in the DNMT3A DNA methylation gene sequences from zebrafish to human and to the less than one percent probability in computer simulation using the HAR1 0.5% probability as reference. The diagram methodology would be useful in ancestral gene

  14. "Les savoirs alimentaires dans le Paris de la fin du Moyen Âge : entre pratique culinaire et hygiène alimentaire"

    OpenAIRE

    Rambourg , Patrick

    2008-01-01

    International audience; Comment se diffusent les savoirs alimentaires dans le Paris de la fin du Moyen Âge ? Tel est le propos de cet article. A cette époque, Paris est déjà une grande ville où affluent des denrées de toutes sortes. Trois pôles diffusent et organisent les savoirs alimentaires : les pouvoirs publics qui légifèrent sur l'approvisionnement et la sécurité du consommateur ; les professionnels de bouche qui codifient les normes de fabrication ; et les Parisiens qui transmettent la ...

  15. Purification, characterization, and sequencing of novel antimicrobial peptides, Tu-AMP 1 and Tu-AMP 2, from bulbs of tulip (Tulipa gesneriana L.).

    Science.gov (United States)

    Fujimura, Masatoshi; Ideguchi, Mineo; Minami, Yuji; Watanabe, Keiichi; Tadera, Kenjiro

    2004-03-01

    Novel antimicrobial peptides (AMP), designated Tu-AMP 1 and Tu-AMP 2, were purified from the bulbs of tulip (Tulipa gesneriana L.) by chitin affinity chromatography and reverse-phase high-performance liquid chromatography (HPLC). They bind to chitin in a reversible way. They were basic peptides having isoelectric points of over 12. Tu-AMP 1 and Tu-AMP 2 had molecular masses of 4,988 Da and 5,006 Da on MALDI-TOF MS analysis, and their extinction coefficients of 1% aqueous solutions at 280 nm were 3.3 and 3.4, respectively. Half of all amino acid residues of Tu-AMP 1 and Tu-AMP 2 were occupied by cysteine, arginine, lysine, and proline. The concentrations of peptides required for 50% inhibition (IC(50)) of the growth of plant pathogenic bacteria and fungi were 2 to 20 microg/ml. The structural characteristics of Tu-AMP 1 and Tu-AMP 2 indicated that they were novel thionin-like antimicrobial peptides, though Tu-AMP 2 was a heterodimer composes of two short peptides joined with disulfide bonds.

  16. Rule based design workshop at the TU Berlin

    DEFF Research Database (Denmark)

    Tamke, Martin; Palz, Norbert; Josefsson, Kristoffer

    A new cluster of a possible series of digital design & digital fabrication workshops held at the Berlin University of Technology (TU Berlin), Department of Building Design, School of Architecture, explores teaching and learning Rule Based Design. The first workshop introduced computational logical...

  17. Defining a Pedagogical Model: The TU Delft Online Learning Experience

    NARCIS (Netherlands)

    Ribeiro Jorge, N.; Dopper, S.M.; van Valkenburg, W.F.

    2015-01-01

    In early 2014, the Delft University of Technology (TU Delft) started an innovation program with the aim to respond even more effectively to recent developments in open and online education. Drawing on the fields of Distance Education research and the university’s vision of the “engineer of the

  18. Roles of Protein Synthesis Elongation Factor EF-Tu in Heat Tolerance in Plants

    Directory of Open Access Journals (Sweden)

    Jianming Fu

    2012-01-01

    Full Text Available EF-Tu proteins of plastids, mitochondria, and the cytosolic counterpart EF-1α in plants, as well as EF-Tu proteins of bacteria, are highly conserved and multifunctional. The functions of EF-Tu include transporting the aminoacyl-tRNA complex to the A site of the ribosome during protein biosynthesis; chaperone activity in protecting other proteins from aggregation caused by environmental stresses, facilitating renaturation of proteins when conditions return to normal; displaying a protein disulfide isomerase activity; participating in the degradation of N-terminally blocked proteins by the proteasome; eliciting innate immunity and triggering resistance to pathogenic bacteria in plants; participating in transcription when an E. coli host is infected with phages. EF-Tu genes are upregulated by abiotic stresses in plants, and EF-Tu plays important role in stress responses. Expression of a plant EF-Tu gene confers heat tolerance in E. coli, maize knock-out EF-Tu null mutants are heat susceptible, and over-expression of an EF-Tu gene improves heat tolerance in crop plants. This review paper summarizes the current knowledge of EF-Tu proteins in stress responses in plants and progress on application of EF-Tu for developing crop varieties tolerant to abiotic stresses, such as high temperatures.

  19. Preparation of Immobilized Recombinant Tubulin Beta(TuBb on Chitosan Nanoparticles by Covalent Binding Method

    Directory of Open Access Journals (Sweden)

    Yan Qingfang

    2016-01-01

    Full Text Available Objective In order to screen TuBb inhibitors, this paper describes the preparation of immobilized TuBb on chitosan nanoparticles. Methods TuBb was immobilized onto chitosan nanoparticles by covalent binding method. Results The results of the univariate test indicated that the highest immobilized yield can be obtained when the optimal immobilization condition was 1 mg of TuBb, 0.5 mol/L of buffer solution with pH 6.5, immobilization 30 min and immobilization at 0-4 °C. Conclusions The authors conclude that the immobilized TuBb maintain the catalysis properties and can be used as the screening of TuBb inhibitors.

  20. Comparison of Plasma Tu-M2-PK and CA19-9 in Pancreatic Cancer

    DEFF Research Database (Denmark)

    Joergensen, Maiken Thyregod; Heegaard, Niels H H; Schaffalitzky de Muckadell, Ove B

    2009-01-01

    alone. The presence of chronic pancreatitis or jaundice causes increased levels of CA19-9 but does not influence Tu-M2-PK. CONCLUSIONS:: Tu-M2-PK was inferior to CA19-9 as marker of PDAC. Tu-M2-PK may have a role in diagnosing PDAC because it is not affected by cholestasis or Lewis phenotype. Neither...

  1. Trust Management in P2P systems using Standard TuLiP

    OpenAIRE

    Czenko, M.R.; Doumen, J.M.; Etalle, Sandro

    2008-01-01

    In this paper we introduce Standard TuLiP - a new logic based Trust Management system. In Standard TuLiP, security decisions are based on security credentials, which can be issued by different entities and stored at different locations. Standard TuLiP directly supports the distributed credential storage by providing a sound and complete Lookup and Inference AlgoRithm (LIAR). In this paper we focus on (a) the language of Standard TuLiP and (b) on the practical considerations which arise when d...

  2. Production of resonances in the T+U region

    CERN Document Server

    Duboc, J

    1974-01-01

    Preliminary results about K pi pi and KK pi production of resonances in pp annihilations are presented. The p momentum covers the range 1.28-2.04 GeV/c and spans the T+U region. The sample of about 26000 events at present on DST corresponds roughly to 90% of the total statistics and has been limited to events with at least one observed V /sup 0/. (2 refs).

  3. Co-ordination of Mobile Information Agents in TuCSoN.

    Science.gov (United States)

    Omicini, Andrea; Zambonelli, Franco

    1998-01-01

    Examines mobile agent coordination and presents TuCSoN, a coordination model for Internet applications based on mobile information agents that uses a tuple centre, a tuple space enhanced with the capability of programming its behavior in response to communication events. Discusses the effectiveness of the TuCSoN model in the contexts of Internet…

  4. Contribution of Arg288 of Escherichia coli elongation factor Tu to translational functionality

    DEFF Research Database (Denmark)

    Rattenborg, Thomas; Nautrup-Pedersen, Gitte; Clark, Brian F. C.

    1997-01-01

    The recently solved structure of the ternary complex formed between GTP-bound elongation factor Tu and aminoacylated tRNA reveals that the elements of aminoacyl-tRNA that interact with elongation factor Tu can be divided into three groups: the T stem; the 3'-end CCA-Phe; and the 5' end. The conse...

  5. The Danish National Travel Survey - declaration of variables : TU 2006-13, version 2

    DEFF Research Database (Denmark)

    Christiansen, Hjalmar; Skougaard, Britt Zoëga

    This record documents the reported data in the data set TU 2006-13 version 2 covering data from the period May 2006 until 30. April 2014. Please refer to our website for the most up-to-date documentation of the latest TU data. This record follows, where possible, the data set and is not updated...

  6. The Danish National Travel Survey - declaration of variables TU 2006-11, version 2

    DEFF Research Database (Denmark)

    Christiansen, Hjalmar

    This record documents the reported data in the data set TU 2006-11 version 2 covering data from the period May 2006 until 30. April 2012. Please refer to our website for the most up-to-date documentation of the latest TU data. This record follows, where possible, the data set and is not updated...

  7. The Danish National Travel Survey - declaration of variables : TU 2006-12, version 1

    DEFF Research Database (Denmark)

    Christiansen, Hjalmar; Skougaard, Britt Zoëga

    This record documents the reported data in the data set TU 2006-12 version 1 covering data from the period May 2006 until 31. December 2012. Please refer to our website for the most up-to-date documentation of the latest TU data. This record follows, where possible, the data set and is not updated...

  8. The Danish National Travel Survey - declaration of variables : TU 2006-10, version 2

    DEFF Research Database (Denmark)

    Christiansen, Hjalmar; Haunstrup, Brian

    This record documents the reported data in the data set TU 2006-10 version 1 covering data from the period May 2006 until 30 April 2011. Please refer to our website for the most up-to-date documentation of the latest TU data. This record follows, where possible, the data set and is not updated...

  9. The Danish National Travel Survey - declaration of variables TU 2006-11, version 1

    DEFF Research Database (Denmark)

    Christiansen, Hjalmar

    This record documents the reported data in the data set TU 2006-11 version 1 covering data from the period May 2006 until 31 December 2011. Please refer to our website for the most up-to-date documentation of the latest TU data. This record follows, where possible, the data set and is not updated...

  10. The Danish National Travel Survey - declaration of variables TU 2006-12, version 2 : Documentation note

    DEFF Research Database (Denmark)

    Christiansen, Hjalmar; Skougaard, Britt Zoëga

    This record documents the reported data in the data set TU 2006-12 version 1 covering data from the period May 2006 until 3o April 2013. Please refer to our website for the most up-to-date documentation of the latest TU data. This record follows, where possible, the data set and is not updated...

  11. Monolītu materiāli hromatogrāfijai

    OpenAIRE

    Picka, Edžus

    2010-01-01

    Aplūkotas literatūrā aprakstītās monolītu īpašības, izgatavošanas metodes un to apstākļi, kā arī monolītu izmantošanas iespējas hromatogrāfijā. Darbā veikta metakrilātu monomēru kapilāro monolītu kolonnu izgatavošana ar termisko polimerizāciju un fotopolimerizāciju, kā arī veikta hromatogrāfiskā analīze, izmantojot fotopolimerizācijas ceļā iegūto monolītu kolonnu.

  12. La racialisation, entre pouvoirs et savoirs : une lecture postcoloniale de la santé publique comme pratique discursive

    Directory of Open Access Journals (Sweden)

    PATRICK CLOOS

    2010-10-01

    Full Text Available Cet article présente et discute la perspective théorique interdisciplinaire qui a été construite lors d'une recherche de doctorat sur la conception contemporaine de la 'race' dans le domaine de la santé publique aux États-Unis. Dans ce contexte, la 'race' a été vue comme un objet qui a été pris en charge par le discours, se situant entre pouvoirs et savoirs comme le suggère Foucault, alors que la santé publique est ici une instance qui participe à la mise en oeuvre du discours et à la formation de l'objet. Certains auteurs du champ des études postcoloniales insistent sur le pouvoir représentationnel associé à ce discours qui correspond à un système d'opposition et de différence créant une dichotomie et assurant la domination des uns sur les autres. Cet article montre que la 'race' persistera aussi longtemps que les conditions historiques et les individus lui permettent d'exister comme idée de la différence.

  13. The gammaTuRC Nanomachine Mechanism and Future Applications

    Science.gov (United States)

    Riehlman, Timothy D.

    The complexity and precision of the eukaryotic cell's cytoskeletal network is unrivaled by any man-made systems, perfected by billions of years of evolution, mastering elegant processes of self-assembly, error correction, and self-repair. Understanding the capabilities of these networks will have important and far reaching applications in human medicine by aiding our understanding of developmental processes, cellular division, and disease mechanisms, and through biomimicry will provide insights for biosynthetic manufacturing at the nanoscale and across scales. My research utilizes cross species techniques from Human to the model organism of Fission Yeast to investigate the structure and mechanisms of the g-tubulin ring complex (gTuRC). The gTuRC is a highly conserved eukaryotic multiprotein complex serving as a microtubule organizing center (MTOC) responsible for microtubule nucleation through templating, regulation of dynamics, and establishment of microtubule polarity. Microtubules are 25 nm diameter dynamic flexible polymers of a/b-tubulin heterodimers that function as scaffolds, force generators, distributors, and intracellular highways. The microtubule cytoskeleton is essential for numerous fundamental cellular processes such as mitotic division of chromosomes and cell division, organelle distribution within the cell, cell signaling, and cell shape. This incredible diversity in functions is made possible in part due to molecular motor Kinesin-like proteins (Klps), which allow expansion into more specialized neural, immune, and ciliated cell functions. Combined, the MTOC, microtubules, and Klps represent ideal microtubule cytoskeleton protein (MCP) modular components for in vitro biomimicry towards generation of adaptable patterned networks for human designed applications. My research investigates the hypothesis that a mechanistic understanding of conserved MTOC gTuRC mechanisms will help us understand dynamic cellular nanomachines and their ability to self

  14. Alteration of nucleoside diphosphate binding specificity of E. coli elongation factor Tu (EF-Tu) by single amino acid substitution at position 138

    International Nuclear Information System (INIS)

    Hwang, Y.; Miller, D.L.

    1987-01-01

    A single amino acid substitution (Asp → Asn) at position 138 of E. coli EF-Tu was induced in the tufA gene by an M13 phage oligonucleotide site-directed mutagenesis protocol. The mutated tufA gene was then subcloned in a plasmid vector and expressed in maxicells. The properties of [ 35 S]methionine labelled mutant and wild type EF-Tu's were compared by in vitro assays. Mutant and wild-type EF-Tu's bound EF-Ts with approximately equal affinities. The 138-Asn mutation greatly reduced the protein's affinity for GDP; however, this mutation dramatically increased the proteins affinity for XDP. The mutant protein forms a stable complex with phe-tRNA and XTP, which binds to ribosomes; whereas, it does not form a complex with phe-tRNA and GTP. These results suggest that in EF-Tu x NDP complexes amino acid residue 138 must interact with the substituent on C-2 of the purine ring. Thus in wild-type EF-Tu Asp-138 would H-bond to 2-NH 2 of GDP, and in the mutant EF-Tu ASN-138 would form an equivalent H-bond with 2-0 of XDP. This explains why Asp-138 is conserved in the guanosine binding domains of nearly all GDP regulatory proteins

  15. The Measure your World / Mide tu Mundo Project

    Science.gov (United States)

    Hojman, S.; Johnson, R. M.; Meymaris, K. K.; Ward, D. L.; Russell, R.; Genyuk, J.; Lagrave, M.; Henderson, S.; Ostrosky, J.; Martinez, M.

    2007-12-01

    Over 22 centuries ago Erathostenes devised a method to determine the Earth radius. Measure your World / Mide tu Mundo is a joint venture lead by Windows to the Universe/Ventanas al Universo in the United States of America, EducaRed in Chile and RedEscolar in Mexico seeking to partner teams of students, teachers and parents from the three countries in a collaborative effort to determine the Earth circumference by sharing the results of their measurements, and exchanging cultural information. Data are collected from September 29 through October 7, 2007. A report of the whole experience will be presented.

  16. TU Electric reactor physics model verification: Power reactor benchmark

    International Nuclear Information System (INIS)

    Willingham, C.E.; Killgore, M.R.

    1988-01-01

    Power reactor benchmark calculations using the advanced code package CASMO-3/SIMULATE-3 have been performed for six cycles of Prairie Island Unit 1. The reload fuel designs for the selected cycles included gadolinia as a burnable absorber, natural uranium axial blankets and increased water-to-fuel ratio. The calculated results for both startup reactor physics tests (boron endpoints, control rod worths, and isothermal temperature coefficients) and full power depletion results were compared to measured plant data. These comparisons show that the TU Electric reactor physics models accurately predict important measured parameters for power reactors

  17. Doc toxin is a kinase that inactivates elongation factor Tu.

    Science.gov (United States)

    Cruz, Jonathan W; Rothenbacher, Francesca P; Maehigashi, Tatsuya; Lane, William S; Dunham, Christine M; Woychik, Nancy A

    2014-03-14

    The Doc toxin from bacteriophage P1 (of the phd-doc toxin-antitoxin system) has served as a model for the family of Doc toxins, many of which are harbored in the genomes of pathogens. We have shown previously that the mode of action of this toxin is distinct from the majority derived from toxin-antitoxin systems: it does not cleave RNA; in fact P1 Doc expression leads to mRNA stabilization. However, the molecular triggers that lead to translation arrest are not understood. The presence of a Fic domain, albeit slightly altered in length and at the catalytic site, provided a clue to the mechanism of P1 Doc action, as most proteins with this conserved domain inactivate GTPases through addition of an adenylyl group (also referred to as AMPylation). We demonstrated that P1 Doc added a single phosphate group to the essential translation elongation factor and GTPase, elongation factor (EF)-Tu. The phosphorylation site was at a highly conserved threonine, Thr-382, which was blocked when EF-Tu was treated with the antibiotic kirromycin. Therefore, we have established that Fic domain proteins can function as kinases. This distinct enzymatic activity exhibited by P1 Doc also solves the mystery of the degenerate Fic motif unique to the Doc family of toxins. Moreover, we have established that all characterized Fic domain proteins, even those that phosphorylate, target pivotal GTPases for inactivation through a post-translational modification at a single functionally critical acceptor site.

  18. Doc Toxin Is a Kinase That Inactivates Elongation Factor Tu*

    Science.gov (United States)

    Cruz, Jonathan W.; Rothenbacher, Francesca P.; Maehigashi, Tatsuya; Lane, William S.; Dunham, Christine M.; Woychik, Nancy A.

    2014-01-01

    The Doc toxin from bacteriophage P1 (of the phd-doc toxin-antitoxin system) has served as a model for the family of Doc toxins, many of which are harbored in the genomes of pathogens. We have shown previously that the mode of action of this toxin is distinct from the majority derived from toxin-antitoxin systems: it does not cleave RNA; in fact P1 Doc expression leads to mRNA stabilization. However, the molecular triggers that lead to translation arrest are not understood. The presence of a Fic domain, albeit slightly altered in length and at the catalytic site, provided a clue to the mechanism of P1 Doc action, as most proteins with this conserved domain inactivate GTPases through addition of an adenylyl group (also referred to as AMPylation). We demonstrated that P1 Doc added a single phosphate group to the essential translation elongation factor and GTPase, elongation factor (EF)-Tu. The phosphorylation site was at a highly conserved threonine, Thr-382, which was blocked when EF-Tu was treated with the antibiotic kirromycin. Therefore, we have established that Fic domain proteins can function as kinases. This distinct enzymatic activity exhibited by P1 Doc also solves the mystery of the degenerate Fic motif unique to the Doc family of toxins. Moreover, we have established that all characterized Fic domain proteins, even those that phosphorylate, target pivotal GTPases for inactivation through a post-translational modification at a single functionally critical acceptor site. PMID:24448800

  19. Genetic control of immunity to Turnip mosaic virus (TuMV) pathotype 1 in Brassica rapa (Chinese cabbage).

    Science.gov (United States)

    Lydiate, Derek J; Pilcher, Rachel L Rusholme; Higgins, Erin E; Walsh, John A

    2014-08-01

    Turnip mosaic virus (TuMV) is the major virus infecting crops of the genus Brassica worldwide. A dominant resistance gene, TuRB01b, that confers immunity to the virus isolate UK 1 (a representative pathotype 1 isolate of TuMV) on Brassica rapa was identified in the Chinese cabbage cultivar Tropical Delight. The TuRB01b locus was mapped to a 2.9-cM interval on B. rapa chromosome 6 (A6) that was flanked by RFLP markers pN101e1 and pW137e1. This mapping used a first backcross (B(1)) population segregating for the resistance gene at TuRB01b and sets of RFLP markers employed in previous mapping experiments in Brassica. Virus-plant interaction phenotypes were assayed in inbred progeny derived from B(1) individuals to allow different virus isolates to be tested. Comparative mapping confirmed that A6 of B. rapa was equivalent to chromosome 6 of Brassica napus (A6) and that the map position of TuRB01b in B. rapa could be identical to that of TuRB01 in B. napus. Detailed evaluation of plant-virus interactions showed that TuRB01 and TuRB01b had indistinguishable specificities to a range of TuMV isolates. The possibility that TuRB01 and TuRB01b represent similar or identical alleles at the same A genome resistance locus suggests that B. napus acquired TuRB01 from the B. rapa gene pool.

  20. Projekt Öko-Audit an der TU Dresden - erste Ergebnisse

    OpenAIRE

    Fröhlich, Jürgen; Günther, Edeltraud; Jetschny, Wolfgang; Klauke, Ines; Winkler, Ute

    2001-01-01

    Zwischenbericht zum Projekt “Multiplikatorwirkung und Implementierung des Öko-Audits an Hochschuleinrichtungen nach EMAS II am Beispiel der TU Dresden“, gefördert durch die Deutsche Bundesstiftung Umwelt

  1. Tunable Light-Guide Image Processing Snapshot Spectrometer (TuLIPSS) for Earth and Moon Observations

    Science.gov (United States)

    Tkaczyk, T. S.; Alexander, D.; Luvall, J. C.; Wang, Y.; Dwight, J. G.; Pawlowsk, M. E.; Howell, B.; Tatum, P. F.; Stoian, R.-I.; Cheng, S.; Daou, A.

    2018-02-01

    A tunable light-guide image processing snapshot spectrometer (TuLIPSS) for Earth science research and observation is being developed through a NASA instrument incubator project with Rice University and Marshall Space Flight Center.

  2. The intensive DT neutron generator of TU Dresden

    Science.gov (United States)

    Klix, Axel; DÖring, Toralf; Domula, Alexander; Zuber, Kai

    2018-01-01

    TU Dresden operates an accelerator-based intensive DT neutron generator. Experimental activities comprise investigation into material activation and decay, neutron and photon transport in matter and R&D work on radiation detectors for harsh environments. The intense DT neutron generator is capable to produce a maximum of 1012 n/s. The neutron source is a solid-type water-cooled tritium target based on a titanium matrix on a copper carrier. The neutron yield at a typical deuteron beam current of 1 mA is of the order of 1011 n/s in 4Π. A pneumatic sample transport system is available for short-time irradiations and connected to wo high-purity germanium detector spectrometers for the measurement of induced activities. The overall design of the experimental hall with the neutron generator allows a flexible setup of experiments including the possibility of investigating larger structures and cooled samples or samples at high temperatures.

  3. Cloning and Characterization of EF-Tu and EF-Ts from Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    Stephanie O. Palmer

    2013-01-01

    Full Text Available We have cloned genes encoding elongation factors EF-Tu and EF-Ts from Pseudomonas aeruginosa and expressed and purified the proteins to greater than 95% homogeneity. Sequence analysis indicated that P. aeruginosa EF-Tu and EF-Ts are 84% and 55% identical to E. coli counterparts, respectively. P. aeruginosa EF-Tu was active when assayed in GDP exchange assays. Kinetic parameters for the interaction of EF-Tu with GDP in the absence of EF-Ts were observed to be = 33 μM, = 0.003 s−1, and the specificity constant was  s−1 μM−1. In the presence of EF-Ts, these values were shifted to = 2 μM, = 0.005 s−1, and the specificity constant was  s−1 μM−1. The equilibrium dissociation constants governing the binding of EF-Tu to GDP ( were 30–75 nM and to GTP ( were 125–200 nM. EF-Ts stimulated the exchange of GDP by EF-Tu 10-fold. P. aeruginosa EF-Tu was active in forming a ternary complex with GTP and aminoacylated tRNA and was functional in poly(U-dependent binding of Phe-tRNAPhe at the A-site of P. aeruginosa ribosomes. P. aeruginosa EF-Tu was active in poly(U-programmed polyphenylalanine protein synthesis system composed of all P. aeruginosa components.

  4. Les chemins du savoir

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cathy Egan

    solutions africaines aux problèmes causés par les politiques d'ajustement structurel sévères imposées par les institutions financières internationales. Aujourd'hui, cet organisme à but non lucratif, se place au premier rang des organismes de recherche en économie en. « Quand la démocratie bat de l'aile dans un pays, tout.

  5. Stratégies de valorisation des savoirs locaux africains : questions et enjeux liés à l’usage du numérique au Cameroun

    OpenAIRE

    Mboa Nkoudou, Thomas Hervé

    2016-01-01

    La question des savoirs locaux suscite de nombreux débats sur la valeur et la considération que les uns et les autres leur accordent. Au-delà des aspects les plus vulgarisés que sont l’environnement et à la pharmacopée, cet article met en évidence une conception plus holiste des savoirs locaux et montre que leur valorisation est un enjeu de justice cognitive. À cette fin, l’auteur propose une stratégie numérique en quatre points adaptée au contexte camerounais : l’acquisition de compétences n...

  6. Function and structure in phage Qbeta RNA replicase. Association of EF-Tu-Ts with the other enzyme subunits

    DEFF Research Database (Denmark)

    Blumenthal, T; Young, R A; Brown, S

    1976-01-01

    of EF-Tu-Ts from the other enzyme subunits: whereas free EF-Tu-Ts binds GDP independently of salt concentration, this binding by Qbeta replicase is sensitive to high ionic strength and remains so in the presence of Qbeta RNA. Furthermore, RNA does not allow the release of EF-Ts from EF-Tu by GTP......Qbeta replicase is a complex of four nonidentical subunits readily dissociable into two subcomplexes: 30 S ribosomal protein S1 and the phage-coded polypeptide (Subunits I + II) and protein synthesis elongation factors EF-Tu and EF-Ts (Subunits III + IV). The affinity of the two subcomplexes...

  7. A kirromycin-resistant EF-Tu species reverses streptomycin dependence of Escherichia coli strains mutated in ribosomal protein S12.

    Science.gov (United States)

    Zuurmond, A M; Zeef, L A; Kraal, B

    1998-12-01

    Streptomycin dependence can be caused by mutations in ribosomal protein S12. Mutations suppressing such streptomycin dependence have been found in ribosomal proteins S4 and S5, and in 16S rRNA. Here a new suppressor mutation localized in elongation factor Tu (EF-Tu) is described, consistent with recent models of ribosome-EF-Tu-tRNA interaction at the decoding centre. The EF-Tu mutation was obtained by genetic selection for streptomycin independence; it was identified as Ala375 --> Thr, previously described as EF-TuA(R) and known to confer a kirromycin-resistant, error-prone phenotype. Also, other streptomycin-dependent (SmD) S12 mutations could be complemented by this mutation. The streptomycin-independent (Sm1) strain grows more slowly than the wild-type (wt), suggesting that not all the defects of the S12 mutation can be complemented by EF-Tu[A375T]. Moreover, this strain is more susceptible than wt to reduction in the cellular EF-Tu concentration, and disruption of tufB led to considerable growth-rate impairment. Expression of EF-Tu from tufB, not only of wt EF-Tu and EF-Tu[A375T] but, remarkably, also of EF-Tu[G222D], known as EF-TuB0 and defective in protein synthesis, equally contributed to cell growth. In vitro analysis revealed a decreased translational activity of wt EF-Tu with SmD ribosomes as compared to EF-Tu[A375T], while EF-Tu[G222D] showed no activity at all, just as with wt ribosomes. Possible mechanisms are discussed for the improved growth rate observed in such Sm1 strains when they include wt EF-Tu or EF-Tu[G222D].

  8. Independent safety analysis - why us? - A perspective from TU electric

    International Nuclear Information System (INIS)

    Rice, B.L.; Boatwright, W.J.; De Vore, C.V.; Lo, S.S.; Maier, S.M.

    1988-01-01

    The development of a plant transient analysis capability at TU Electric was initiated in 1982 for Comanche Peak operations support. This type of support was available from the NSSS vendor, but the timeliness and cost of vendor responses to requests for services become a concern. RETRAN-02 MOD002 was acquired at that time for developing a best estimate model of Comanche Peak Unit 1. The activities of the Transient Analysis Section have evolved to a point where operations support is no longer the primary activity. RETRAN is also being used for the development of reload licensing methods and the resolution of licensing concerns raised internally or by the Nuclear Regulatory Commission (NRC). Future uses of RETRAN include simulator certification, as required by Regulatory Guide 1.149, and Justifications for Continued Operation for the plants. Benefits similar to those experienced through the RETRAN activities are expected in the following areas currently being developed: core thermal-hydraulics, fuel performance, LOCA, and systems analysis (PRA and reliability analysis). The major benefit expected from these activities is the development of a thorough understanding of plant operations and the in-house ability to handle operations and licensing questions, concerns and problems in a timely and cost effective manner

  9. The intensive DT neutron generator of TU Dresden

    Directory of Open Access Journals (Sweden)

    Klix Axel

    2018-01-01

    Full Text Available TU Dresden operates an accelerator-based intensive DT neutron generator. Experimental activities comprise investigation into material activation and decay, neutron and photon transport in matter and R&D work on radiation detectors for harsh environments. The intense DT neutron generator is capable to produce a maximum of 1012 n/s. The neutron source is a solid-type water-cooled tritium target based on a titanium matrix on a copper carrier. The neutron yield at a typical deuteron beam current of 1 mA is of the order of 1011 n/s in 4Π. A pneumatic sample transport system is available for short-time irradiations and connected to wo high-purity germanium detector spectrometers for the measurement of induced activities. The overall design of the experimental hall with the neutron generator allows a flexible setup of experiments including the possibility of investigating larger structures and cooled samples or samples at high temperatures.

  10. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

    Science.gov (United States)

    Mills, S M; Mallmann, J; Santacruz, A M; Fuqua, A; Carril, M; Aisen, P S; Althage, M C; Belyew, S; Benzinger, T L; Brooks, W S; Buckles, V D; Cairns, N J; Clifford, D; Danek, A; Fagan, A M; Farlow, M; Fox, N; Ghetti, B; Goate, A M; Heinrichs, D; Hornbeck, R; Jack, C; Jucker, M; Klunk, W E; Marcus, D S; Martins, R N; Masters, C M; Mayeux, R; McDade, E; Morris, J C; Oliver, A; Ringman, J M; Rossor, M N; Salloway, S; Schofield, P R; Snider, J; Snyder, P; Sperling, R A; Stewart, C; Thomas, R G; Xiong, C; Bateman, R J

    2013-10-01

    The Dominantly Inherited Alzheimer's Network Trials Unit (DIAN-TU) was formed to direct the design and management of interventional therapeutic trials of international DIAN and autosomal dominant Alzheimer's disease (ADAD) participants. The goal of the DIAN-TU is to implement safe trials that have the highest likelihood of success while advancing scientific understanding of these diseases and clinical effects of proposed therapies. The DIAN-TU has launched a trial design that leverages the existing infrastructure of the ongoing DIAN observational study, takes advantage of a variety of drug targets, incorporates the latest results of biomarker and cognitive data collected during the observational study, and implements biomarkers measuring Alzheimer's disease (AD) biological processes to improve the efficiency of trial design. The DIAN-TU trial design is unique due to the sophisticated design of multiple drugs, multiple pharmaceutical partners, academics servings as sponsor, geographic distribution of a rare population and intensive safety and biomarker assessments. The implementation of the operational aspects such as home health research delivery, safety magnetic resonance imagings (MRIs) at remote locations, monitoring clinical and cognitive measures, and regulatory management involving multiple pharmaceutical sponsors of the complex DIAN-TU trial are described. Published by Elsevier Masson SAS.

  11. The YvfTU Two-component System is involved in plcR expression in Bacillus cereus

    Directory of Open Access Journals (Sweden)

    Nguyen-the Christophe

    2008-10-01

    Full Text Available Abstract Background Most extracellular virulence factors produced by Bacillus cereus are regulated by the pleiotropic transcriptional activator PlcR. Among strains belonging to the B. cereus group, the plcR gene is always located in the vicinity of genes encoding the YvfTU two-component system. The putative role of YvfTU in the expression of the PlcR regulon was therefore investigated. Results Expression of the plcR gene was monitored using a transcriptional fusion with a lacZ reporter gene in a yvfTU mutant and in its B. cereus ATCC 14579 parental strain. Two hours after the onset of the stationary phase, a stage at which the PlcR regulon is highly expressed, the plcR expression in the yvfTU mutant was only 50% of that of its parental strain. In addition to the reduced plcR expression in the yvfTU mutant, a few members of the PlcR regulon showed a differential expression, as revealed by transcriptomic and proteomic analyses. The virulence of the yvfTU mutant in a Galleria mellonella insect model was slightly lower than that of the parental strain. Conclusion The YvfTU two-component system is not required for the expression of most of the virulence factors belonging to the PlcR regulon. However, YvfTU is involved in expression of plcR, a major regulator of virulence in B. cereus.

  12. Mutation of the conserved Gly83 and Gly94 in Escherichia coli elongation factor Tu. Indication of structural pivots

    DEFF Research Database (Denmark)

    Kjaersgård, I V; Knudsen, Charlotte Rohde; Wiborg, O

    1995-01-01

    Elongation factor Tu from Escherichia coli cycles between an active conformation where GTP is bound, and an inactive conformation where GDP is bound. Between the two conformations, elongation factor Tu undergoes major structural changes. The aim of this work has been to reveal the role of two very...

  13. The YvfTU two-component system is involved in plcR expression in Bacillus cereus.

    Science.gov (United States)

    Brillard, Julien; Susanna, Kim; Michaud, Caroline; Dargaignaratz, Claire; Gohar, Michel; Nielsen-Leroux, Christina; Ramarao, Nalini; Kolstø, Anne-Brit; Nguyen-the, Christophe; Lereclus, Didier; Broussolle, Véronique

    2008-10-16

    Most extracellular virulence factors produced by Bacillus cereus are regulated by the pleiotropic transcriptional activator PlcR. Among strains belonging to the B. cereus group, the plcR gene is always located in the vicinity of genes encoding the YvfTU two-component system. The putative role of YvfTU in the expression of the PlcR regulon was therefore investigated. Expression of the plcR gene was monitored using a transcriptional fusion with a lacZ reporter gene in a yvfTU mutant and in its B. cereus ATCC 14579 parental strain. Two hours after the onset of the stationary phase, a stage at which the PlcR regulon is highly expressed, the plcR expression in the yvfTU mutant was only 50% of that of its parental strain. In addition to the reduced plcR expression in the yvfTU mutant, a few members of the PlcR regulon showed a differential expression, as revealed by transcriptomic and proteomic analyses. The virulence of the yvfTU mutant in a Galleria mellonella insect model was slightly lower than that of the parental strain. The YvfTU two-component system is not required for the expression of most of the virulence factors belonging to the PlcR regulon. However, YvfTU is involved in expression of plcR, a major regulator of virulence in B. cereus.

  14. On the Potentials for Synergy Between COST Action TU1406 and the JCSS

    DEFF Research Database (Denmark)

    Nielsen, Michael Havbro Faber

    On of the main challenges of COST Action TU1406 is to identify, categorize and to the extent possible represent performance indicators of roadway bridges in a manner supporting decision making for their service life integrity management. This calls for an information consistent approach accounting...... Committee to improve the general knowledge on structural safety. The main expertise of the JCSS is centered on the probabilistic modeling of structural performance characteristics of relevance for their safety and efficiency - and aligns well with many of the challenges of COST Action TU1406. The present...... paper thus first provides a short overview of the past and present activities of the JCSS. Thereafter a summary of the some of the key challenges of COST Action 1406 are outlined together with a proposal for their synthetization. Finally, ideas on how the COST Action TU1406 could contribute to the work...

  15. Harmonization of sound insulation descriptors and classification schemes in Europe: COST Action TU0901

    DEFF Research Database (Denmark)

    Rasmussen, Birgit

    -in-Chief. Handbook of noise and vibration control, USA: Wiley and Son; 2007 [Ch. 114]. [4] COST Action TU0901 “Integrating and Harmonizing Sound Insulation Aspects in Sustainable Urban Housing Constructions”, 2009-2013, www.cost.eu/index.php?id=240&action_number=tu0901 (public information at COST website) or http...... Sound Insulation Aspects in Sustainable Urban Housing Constructions" has been approved and runs for four years from November 2009. Until now (end 2010), 28 countries in Europe and 3 overseas countries have signed up for TU0901, and about 85 people have been nominated for the management committee...... of the inhabitants and the society. References [1] "Sound insulation between dwellings – Descriptors in building regulations in Europe" by Birgit Rasmussen & Jens Holger Rindel. Applied Acoustics, 2010, 71(3), 171-180. http://dx.doi.org/10.1016/j.apacoust.2009.05.002 [2] "Sound insulation between dwellings...

  16. Calibration Methods for Air Coupled Antennas - COST Action TU1208

    Science.gov (United States)

    Marecos, Vânia; Solla, Mercedes; Fontul, Simona; Pajewski, Lara

    2016-04-01

    This work focuses on the comparison of different methods for calibrating air coupled antennas: Coring, Surface Reflection Method (SRM) and Common Mid-Point (CMP) through the analysis of GPR data collected in a test site with different pavement solutions. Research activities have been carried out during a Short Term Scientific Mission (STSM) funded by the COST (European Cooperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" in December 2015. The use of GPR in transport infrastructures represents one of the most significant advances for obtaining continuous data along the road, with the advantage of operation at traffic speed and being a non-destructive technique. Its main application has been the evaluation of layer thickness. For the determination of layer thickness, it is necessary to know the velocity of the signal, which depends on the dielectric constant of the material, and the two-way travel time of the reflected signal that is recorded by the GPR system. The calculation of the dielectric value of the materials can be done using different approaches such as: using fixed values based on experience, laboratory determination of dielectric values, applying the SRM, performing back calculation from ground truth references such as cores and test pits, or using the CMP method. The problem with using ground truth is that it is time consuming, labour intensive and intrusive to traffic, in addition, a drill core is not necessarily representative of the whole surveyed area. Regarding the surface reflection technique, one of the problems is that it only measures the dielectric value from the layer surface and not from the whole layer. Recent works already started to address some of these challenges proposing new approaches for GPR layer thickness measurements using multiple antennas to calculate the average dielectric value of the asphalt layer, taking advantage of significant hardware improvements in GPR

  17. The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu.

    Science.gov (United States)

    Castro-Roa, Daniel; Garcia-Pino, Abel; De Gieter, Steven; van Nuland, Nico A J; Loris, Remy; Zenkin, Nikolay

    2013-12-01

    Fic proteins are ubiquitous in all of the domains of life and have critical roles in multiple cellular processes through AMPylation of (transfer of AMP to) target proteins. Doc from the doc-phd toxin-antitoxin module is a member of the Fic family and inhibits bacterial translation by an unknown mechanism. Here we show that, in contrast to having AMPylating activity, Doc is a new type of kinase that inhibits bacterial translation by phosphorylating the conserved threonine (Thr382) of the translation elongation factor EF-Tu, rendering EF-Tu unable to bind aminoacylated tRNAs. We provide evidence that EF-Tu phosphorylation diverged from AMPylation by antiparallel binding of the NTP relative to the catalytic residues of the conserved Fic catalytic core of Doc. The results bring insights into the mechanism and role of phosphorylation of EF-Tu in bacterial physiology as well as represent an example of the catalytic plasticity of enzymes and a mechanism for the evolution of new enzymatic activities.

  18. CWI and TU Delft at TREC 2013: Contextual Suggestion, Federated Web Search, KBA, and Web Tracks

    NARCIS (Netherlands)

    A. Bellogín Kouki (Alejandro); G.G. Gebremeskel (Gebre); J. He (Jiyin); J.J.P. Lin (Jimmy); A. Said (Alan); T. Samar (Thaer); A.P. de Vries (Arjen); J.B.P. Vuurens (Jeroen)

    2014-01-01

    htmlabstractThis paper provides an overview of the work done at the Centrum Wiskunde & Informatica (CWI) and Delft University of Technology (TU Delft) for different tracks of TREC 2013. We participated in the Contextual Suggestion Track, the Federated Web Search Track, the Knowledge Base

  19. RESULTS OF AIRPLANE TU-204-300 OPERATED BY "VLADIVOSTOK AVIA" COMPANY FUEL FLOW MONITIRING

    Directory of Open Access Journals (Sweden)

    G. E. Maslennikova

    2014-01-01

    Full Text Available This article describes the results obtained from continuous monitoring of fuel flow on the airplanes Tu-204-300, operated by the aircompany "Vladivostok Avia". The reasons for the change in the cost of each copy of airplane and changes in fuel characteristics due to pilots manner of flying.

  20. Všechno už tu bylo. Jenom trochu menší.

    Czech Academy of Sciences Publication Activity Database

    Mikuláš, Radek

    2016-01-01

    Roč. 95, č. 3 (2016), s. 154-157 ISSN 0042-4544 Institutional support: RVO:67985831 Keywords : geology * geological history of the Earth * historical geology * geological eras * Anthropocene * paleontology * ichnology * fossils * trace fossils * fossil animals * sediments Subject RIV: DB - Geology ; Mineralogy http://casopis.vesmir.cz/clanek/vsechno-uz-tu-bylo

  1. Česká literatura a kultura za protektorátu

    Czech Academy of Sciences Publication Activity Database

    Piorecký, Karel

    2017-01-01

    Roč. 65, č. 3 (2017), s. 482-485 ISSN 0009-0468. [Česká literatura a kultura za protektorátu. Ostrava, 24.11.2016-25.11.2016] Institutional support: RVO:68378068 Keywords : Czech literature * 1938-1945 Subject RIV: AJ - Letters, Mass-media, Audiovision

  2. Two axiomatizations of the kernel of TU games: bilateral and converse reduced game properties

    NARCIS (Netherlands)

    Driessen, Theo; Hu, C.-C.

    We provide two axiomatic characterizations of the kernel of TU games by means of both bilateral consistency and converse consistency with respect to two types of two-person reduced games. According to the first type, the worth of any single player in the two-person reduced game is derived from the

  3. Marketing digital. Guía básica para digitalizar tu empresa

    OpenAIRE

    Sánchez Hervás, David

    2016-01-01

    Reseña, para sección Tribuna de adComunica, del libro: Martínez Polo, Josep M.; Martínez Sánchez. Jesús y Parra, M. Concepción (2015). Marketing Digital. Guía básica para digitalizar tu empresa. Barcelona: Editorial UOC.

  4. Manûtu ša Bābili = the Babylonian subdivision of the mina

    NARCIS (Netherlands)

    van der Spek, R.J.

    A new interpretation of the term Manûtu ša Bābili is presented here. It is not the exchange rate between shekels and drachmas, as was generally assumed, but it is the Babylonian subdivision ("counting") of the mina as opposed to the Greek mina. A Babylonian mina counts 30 staters, a Greek mina 25

  5. Mutational analysis of Escherichia coli elongation factor Tu in search of a role for the N-terminal region

    DEFF Research Database (Denmark)

    Mansilla, Francisco; Knudsen, Charlotte Rohde; Laurberg, M

    1998-01-01

    We have mutated lysine 2 and arginine 7 in elongation factor Tu from Escherichia coli separately either to alanine or glutamic acid. The aim of the work was to reveal the possible interactions between the conserved N-terminal part of the molecule, which is rich in basic residues and aminoacyl...... this activity. Furthermore, arginine 7 seems to play a role in regulating the binding of GTP. The three-dimensional structure of the ternary complex, EF-Tu:GTP:Phe-tRNAPhe, involving Thermus aquaticus EF-Tu and yeast Phe-tRNA(Phe), shows that Arg7 is in a position which permits salt bridge formation with Asp284...

  6. Savoirs paysans autour des huiles d’olive, (zaytun, Olea europaea var. europaea) et d’oléastre, (əl-bərri, Olea europaea var. sylvestris) Rif, nord du Maroc

    OpenAIRE

    Aumeeruddy-Thomas, Yildiz; Caubet, Dominique

    2017-01-01

    Dans cet article, nous nous intéressons centralement aux produits de l’olivier et de l’oléastre du Nord du Maroc, aux modalités techniques d’obtention de différents types d’huile et ce que ces produits représentent pour les habitants. Il s’agit de comprendre si le Rif détient une particularité sur ce sujet. Nous suggérons que ces techniques et les savoirs et savoir-faire sur les huiles ont pu influencer des processus pré-domesticatoire et de création variétale dans le nord du Maroc. Nous cher...

  7. Contribution des savoir-faire viticoles au développement durable et à la démarche de responsabilité Sociétale et environnementale, dans le cadre d'une gouvernance patrimoniale des terroirs

    Directory of Open Access Journals (Sweden)

    Rochard Joël

    2017-01-01

    Full Text Available Les savoirs viticoles constituent, au-delà des atouts locaux, un patrimoine humain irremplaçable. Le génie des hommes a permis à de nombreux écosystèmes terrestres, y compris parfois les plus extrêmes, d'être valorisés afin d'exprimer la quintessence du vin, expression des terroirs, ainsi que des particularités historiques et culturelles locales. Au-delà de la dimension territoriale, les savoir-faire viticoles sont également porteurs de dynamique locale, de préservation et de valorisation. Par ailleurs, ceux-ci peuvent alimenter la créativité scientifique et technologique dans une période de post modernité, en proie à des doutes et parfois des impasses, en quête de valeurs traditionnelles. La communication, à partir d'exemples, souligne la contribution des savoirs historiques locaux à une culture et une gouvernance, indispensable à la valorisation des terroirs et des vins, mais également au développement de démarche opérationnelle du développement durable en lien notamment avec la responsabilité sociale et environnementale de la filière viticole, vis-à-vis de notre planète et des générations futures.

  8. Function and structure in phage Qbeta RNA replicase. Association of EF-Tu-Ts with the other enzyme subunits

    DEFF Research Database (Denmark)

    Blumenthal, T; Young, R A; Brown, S

    1976-01-01

    of EF-Tu-Ts from the other enzyme subunits: whereas free EF-Tu-Ts binds GDP independently of salt concentration, this binding by Qbeta replicase is sensitive to high ionic strength and remains so in the presence of Qbeta RNA. Furthermore, RNA does not allow the release of EF-Ts from EF-Tu by GTP...... for one another increases with increasing ionic strength. The enzyme is capable of initiation of RNA synthesis with synthetic templates only when in the low ionic strength conformation. Elongation of initiated polynucleotide chains is not affectedby ionic strength. Addition of Qbeta RNA to the enzyme also...... alters its quaternary structure: the EF-Tu-Ts cannot be covalently attached to the other enzyme subunits with bifunctional cross-linking reagents in the presence of RNA. This conformational change is not influenced by ionic strength. The addition of Qbeta RNA to the enzyme, does not result in the release...

  9. Les recueils de questions-réponses à l'Epoque Moderne : une forme de transmission du savoir scientifique ?1

    Directory of Open Access Journals (Sweden)

    Ventura Iolanda

    2015-01-01

    Full Text Available Mon article traite du genre littéraire des recueils scientifiques de questions-réponses, et en particulier des critères qui permettent une identification et une caractérisation des différents types de textes structurés de cette façon. Ces critères, tels que la structure des unités textuelles formées par les questions et les réponses, la présence et le rôle des sources, la séquence des sujets et l'image du monde de la nature livrée par ces œuvres, permettent aussi de mieux comprendre le rôle et la fonction de chaque texte et type de texte, ainsi que du genre littéraire en général, dans le mouvement de transmission du savoir au Moyen Age, à la Renaissance et à l'Epoque moderne. A l'aide de ces critères, je livre une analyse de deux recueils écrits au XVIe et au XVIIe siècle, les Problemas de Francisco Lopez de Villalobos et les Pensieri diversi d'Alessandro Tassoni.

  10. Progress of the COST Action TU1402 on the Quantification of the Value of Structural Health Monitoring

    DEFF Research Database (Denmark)

    Thöns, Sebastian; Limongelli, Maria Pina; Ivankovic, Ana Mandic

    2017-01-01

    This paper summarizes the development of Value of Structural Health Monitoring (SHM) Information analyses and introduces the development, objectives and approaches of the COST Action TU1402 on this topic. SHM research and engineering has been focused on the extraction of loading, degradation...... encompassing the infrastructure and the SHM systems, their functionality and thus require the interaction of several research disciplines. For progressing on these points, a scientific networking and dissemination project namely the COST Action TU1402 has been initiated....

  11. Duplication of Drosophila melanogaster mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues.

    Science.gov (United States)

    Sato, Aya; Suematsu, Takuma; Aihara, Koh-Ki; Kita, Kiyoshi; Suzuki, Tsutomu; Watanabe, Kimitsuna; Ohtsuki, Takashi; Watanabe, Yoh-Ichi

    2017-03-07

    Translation elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA (aa-tRNA) to ribosomes in protein synthesis. EF-Tu generally recognizes aminoacyl moieties and acceptor- and T-stems of aa-tRNAs. However, nematode mitochondrial (mt) tRNAs frequently lack all or part of the T-arm that is recognized by canonical EF-Tu. We previously reported that two distinct EF-Tu species, EF-Tu1 and EF-Tu2, respectively, recognize mt tRNAs lacking T-arms and D-arms in the mitochondria of the chromadorean nematode Caenorhabditis elegans C. elegans EF-Tu2 specifically recognizes the seryl moiety of serylated D-armless tRNAs. Mitochondria of the enoplean nematode Trichinella possess three structural types of tRNAs: T-armless tRNAs, D-armless tRNAs, and cloverleaf tRNAs with a short T-arm. Trichinella mt EF-Tu1 binds to all three types and EF-Tu2 binds only to D-armless Ser-tRNAs, showing an evolutionary intermediate state from canonical EF-Tu to chromadorean nematode (e.g. C. elegans ) EF-Tu species. We report here that two EF-Tu species also participate in Drosophila melanogaster mitochondria. Both D. melanogaster EF-Tu1 and EF-Tu2 bound to cloverleaf and D-armless tRNAs. D. melanogaster EF-Tu1 has the ability to recognize T-armless tRNAs that do not evidently exist in D. melanogaster mitochondria, but do exist in related arthropod species. In addition, D. melanogaster EF-Tu2 preferentially bound to aa-tRNAs carrying small amino acids, but not to aa-tRNAs carrying bulky amino acids. These results suggest that the Drosophila mt translation system could be another intermediate state between the canonical and nematode mitochondria-type translation systems. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

  12. On the Potentials for Synergy Between COST Action TU1406 and the JCSS

    DEFF Research Database (Denmark)

    Nielsen, Michael Havbro Faber

    On of the main challenges of COST Action TU1406 is to identify, categorize and to the extent possible represent performance indicators of roadway bridges in a manner supporting decision making for their service life integrity management. This calls for an information consistent approach accounting...... for the experience and statistical evidence collected from past performances as well as any relevant models relating to their future performances – with due consideration of associated uncertainties. The Joint Committee on Structural Safety (JCSS) is a pre-normative committee mandated by the in 1971 by the Liaison...... Committee to improve the general knowledge on structural safety. The main expertise of the JCSS is centered on the probabilistic modeling of structural performance characteristics of relevance for their safety and efficiency - and aligns well with many of the challenges of COST Action TU1406. The present...

  13. Geotechnical research on Jiangnan Tu-Dun tomb historical remains in China.

    Science.gov (United States)

    Lu, Jiang; Onitsuka, Katsutada

    2004-03-01

    Geotechnical research on historical remains can provide new data and distinctive viewpoint for research on soil mechanics. Two Jiangnan Tu-Dun tombs historical remains were investigated by means of in situ and laboratory geotechnical tests. In the present paper the geotechnical properties of these man-made earthworks, especially ageing effect on consolidation and direct shear, and compaction properties of earth fill are discussed.

  14. Proteosynthetic elongation factor EF-Tu domains: Thermal stability, adaptation and functions

    Czech Academy of Sciences Publication Activity Database

    Jonák, Jiří; Šanderová, Hana; Hůlková, Marta; Maloň, Petr; Krásný, Libor; Kepková, M.

    2009-01-01

    Roč. 16, 1a (2009), b23-b24 ISSN 1211-5894. [Meeting of the Czechoslovak and Slovak Biologists /7./. 12.03.2009-14.03.2009, Nové Hrady] R&D Projects: GA MŠk 2B06065; GA MZd NR9138 Institutional research plan: CEZ:AV0Z50520514; CEZ:AV0Z40550506 Keywords : EF-Tu * proteosynthetic elongation factor * thermal stability Subject RIV: EB - Genetics ; Molecular Biology

  15. Bacterial elongation factors EF-Tu, their mutants, chimeric forms, and domains: isolation and purification

    Czech Academy of Sciences Publication Activity Database

    Jonák, Jiří

    2007-01-01

    Roč. 849, 1-2 (2007), s. 141-153 ISSN 1570-0232 R&D Projects: GA AV ČR IAA5052206; GA AV ČR KJB500520503; GA MŠk 2B06065 Institutional research plan: CEZ:AV0Z50520514 Keywords : bacterial elongation factors EF-Tu, , G-domain * recombinant EF-Tus * preparation Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.935, year: 2007

  16. Töötu laevamehhaanik õppis seitsme kuuga kokaks / Agne Narusk

    Index Scriptorium Estoniae

    Narusk, Agne, 1971-

    2004-01-01

    Töötu Jevgeni Solovjov õppis OÜ-s Isabella kokaks, ettevõte on üks 54 koolitajast, kellelt Tallinna tööhõiveamet teenust ostab. 2004. aastaks oli Tallinna tööhõiveametil tööotsijate koolitamiseks 7 mln krooni, millest jätkus pooleks aastaks. Lisa: Tööandjad saavad küsitluslehed

  17. A new condensed toluene mechanism for Carbon Bond: CB05-TU

    Science.gov (United States)

    Whitten, Gary Z.; Heo, Gookyoung; Kimura, Yosuke; McDonald-Buller, Elena; Allen, David T.; Carter, William P. L.; Yarwood, Greg

    2010-12-01

    Toluene is ubiquitous in urban atmospheres and is a precursor to tropospheric ozone and aerosol (smog). An important characteristic of toluene chemistry is the tendency of some degradation products (e.g., cresols and methyl-catechols) to form organic nitro and nitrate compounds that sequester NOx (NO and NO 2) from active participation in smog formation. Explaining the NOx sinks in toluene degradation has made mechanism development more difficult for toluene than for many other organic compounds. Another challenge for toluene is explaining sources of radicals early in the degradation process. This paper describes the development of a new condensed toluene mechanism consisting of 26 reactions, and evaluates the performance of CB05 with this new toluene scheme (Toluene Update, TU) against 38 chamber experiments at 7 different environmental chambers, and provides recommendations for future developments. CB05 with the current toluene mechanism (CB05-Base) under-predicted the maximum O 3 and O 3 production rate for many of these toluene-NOx chamber experiments, especially under low-NOx conditions ([NOx] t=0 toluene mechanism (CB05-TU) includes changes to the yields and reactions of cresols and ring-opening products, and showed better performance than CB05-Base in predicting the maximum O 3, O 3 formation rate, NOx removal rate and cresol concentration. Additional environmental chamber simulations with xylene-NOx experiments showed that the TU mechanism updates tended to improve mechanism performance for xylene.

  18. Christophe Bonneuil et Frédéric Thomas, Gènes, pouvoirs et profits. Recherche publique et régimes de production des savoirs de Mendel aux OGM

    OpenAIRE

    Letté, Michel

    2014-01-01

    Quelle fonction la recherche publique devrait-elle désormais assigner à l’Institut national de la recherche agronomique (Inra) ? Telle est la question ambitieuse à laquelle les auteurs tentent de répondre en interrogeant l’histoire de cette institution créée en 1946. Partant de sa vocation première – la production et à la régulation des savoirs comme des innovations variétales – ils analysent sa politique de recherche à travers les évolutions d’un secteur mis sous tension par la confrontation...

  19. La télémédecine facilite le partage du savoir médical L'exemple du réseau ARPEGES Télémed (département de l'Indre)

    OpenAIRE

    Thorigny, Maxime; Caudron, Didier

    2016-01-01

    International audience; Nous cherchons à démontrer quels sont les effets induits de la pratique de la télémédecine dans l’exercice médical de deux manières et en quoi cela peut augmenter l’attractivité d’un territoire par la rupture de l’isolement professionnel par un processus d’auto-renforcement : elle participe à la diffusion du savoir médical entre praticiens, sa pratique modifie la perception qu’ont les acteurs des limites de cette nouvelle organisation des soins.

  20. La prison (et sa réforme), un enjeu formateur pour l’État républicain en construction. Innovation administrative, inventivité des savoirs, intensité des politiques.

    OpenAIRE

    Kaluszynski, Martine

    2016-01-01

    International audience; La prison (et sa réforme), un enjeu formateur pour l'État républicain en construction. Innovation administrative, inventivité des savoirs, intensité des politiques. Martine KaluszynskiCNRS Pacte /Grenoble Revue crminocorpus Criminocorpus [En ligne], Varia, mis en ligne le 24 février 2016, consulté le 24 février 2016. URL : https://criminocorpus.revues.org/3173 Au XIX e siècle, la réforme pénitentiaire et par là même la prison ont été de vrais projets politiques mobilis...

  1. Tööotsija töötuks tunnistamise ning töötu abiraha määramise ja maksmise ajutise juhendi kinnitamise kohta

    Index Scriptorium Estoniae

    1991-01-01

    Kehtib 1. aprillist 1991. Lisatud ajutine juhend: töö vahendamine tööotsijale, töötule, töötu abiraha määramine ja maksmine Lisatud: töötu abiraha arvutamine. Muudatus: RT I 1992 nr. 27 art. 362

  2. Site-directed mutagenesis of Arg58 and Asp86 of elongation factor Tu from Escherichia coli: effects on the GTPase reaction and aminoacyl-tRNA binding

    DEFF Research Database (Denmark)

    Knudsen, Charlotte Rohde; Clark, Brian F. C.

    1996-01-01

    Elongation factor Tu from Escherichia coli was mutated separately at positions Asp86 and Arg58, in order to shed light both on the GTPase mechanism of elongation factor Tu and on the binding of aminoacyl-tRNA. In addition, the binding of guanine nucleotides was investigated by determination...

  3. [Talking about the scene of diet and cooking based on Pao Chu Tu (kitchen picture) of Han dynasty].

    Science.gov (United States)

    Yang, Jin-ping

    2009-01-01

    The Pao Chu Tu (kitchen picture) of Han dynasty stone relief reconstructed the state of dietary cooking of Han dynasty with vivid and authentic picture. The Pao Chu Tu (kitchen picture) of Shandong Zhucheng city depicted ancient enormous and busy cooking scene which involved all kinds of cooking activities such as butcher, bailing, stewing, roast and brewing wine etc, displaying the advanced kitchen ware e.g. kettle, caldron, tripod, oven and complex cooking technology of Han Chinese people such as steaming, boiling, stirring baking and roast etc, reflecting rich dietary categories of Han dynasty. The Pao Chu Tu (kitchen picture) of Han dynasty stone relief provide us precious datas for the purpose of the study of dietary living of Han dynasty.

  4. Transportvaneundersøgelsen - Variabeldeklaration : TU 2006-09, version 2

    DEFF Research Database (Denmark)

    Christiansen, Hjalmar

    , eller anden årsag. Undervejs omtales en række vigtige detaljer ved spørgeskemaet, men dette notat har ikke til formål at give en udtømmende beskrivelse af hvilke spørgsmål, der er stillet til hvem og hvornår. Her kan det være til stor nytte at besøge testspørgeskemaet på http://tu2010.dk/dev/starttest.php...

  5. Hágase tu voluntad: Una muestra de virtuosismo periodístico.

    Directory of Open Access Journals (Sweden)

    Simón Espinosa Jalil

    2008-09-01

    Full Text Available Descubrir al ser humano detrás de la fría noticia e intentar ponerse en los zapatos del otro para revelar ese descubrimiento a sus lectores, es el primer mandamiento de un cronista. Se analiza la obra "Hágase tu voluntad" de Germán Caycedo que relata la muerte de Monseñor Alejandro Labaka y de la hermana Inés Arango. En la obra se explora el tema de choque cultural, y narra las distintas historias que conforman la gran tragedia del holocausto de los indígenas amazónicos

  6. Un Nouveau Monde du Savoir

    International Development Research Centre (IDRC) Digital Library (Canada)

    internationalisation. 293. Annexe 2. Collaborateurs. 301 ...... En sciences sociales et humaines, le Canada a produit en 1995 environ 5 500 articles dans les revues recensées par le Social Sciences Citation Index. Bien que cette base de données soit moins ...

  7. H1 - antihistamīna preparātu aprite aptiekās

    OpenAIRE

    Palamarčuka, Nadežda

    2009-01-01

    Maģistra darba mērķis bija noskaidrot, kādi H1-antihistamīna preparāti ir vislabāk pazīstami un tiek visvairāk pirkti aptiekās. Pētījumā tika aptaujāti 100 pacienti un analizēti lieltirgotavas MagnumMedical H1-antihistamīna preparātu tirdzniecības apjomi. Iegūtie rezultāti liecina, ka vislielākais H1-antihistamīna preparātu patēriņš ir pirmās paaudzes preparātiem Tavegyl (klemastīns) un Suprastin (hloropiramīns), jo to iegādei nav nepieciešamas receptes, tie ir salīdzinoši lēti un ir bijuši p...

  8. The "Da Ming Hunyi Tu": Repurposing a Ming Map in Sino-African Diplomacy

    Directory of Open Access Journals (Sweden)

    Alexander Akin

    2016-12-01

    Full Text Available In 2002, an exhibition at South Africa’s parliament included a reproduction of the Da Ming Hunyi Tu (Amalgamated map of the Great Ming, citing it as the earliest world map to depict the entire African continent. As part of its broader efforts to shape a narrative of long-standing and peaceful international relations with Africa, the People’s Republic of China formally presented a replica of this map as a gift to the South African government in conjunction with the exhibition. In official statements and popular media coverage alike, the map was described as evidence of a distinctly Chinese approach to global relations, based on benevolence and mutual respect. In particular, the map was ahistorically intertwined with the legacy of Zheng He’s diplomatic expeditions, which reached the East African coast in the early 1400s. To the cartographic historian, however, the depiction of Africa in the Da Ming Hunyi Tu is clearly derived from non-Chinese sources that predate Zheng He’s expeditions. This article examines the ways in which the map has been divorced from its original context to suit modern needs, exemplifying the deployment of cartography to deflect anxieties about the nature of Chinese economic influence in South Africa.

  9. An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

    Energy Technology Data Exchange (ETDEWEB)

    Whitney, John C.; Quentin, Dennis; Sawai, Shin; LeRoux, Michele; Harding, Brittany N.; Ledvina, Hannah E.; Tran, Bao Q.; Robinson, Howard; Goo, Young Ah; Goodlett, David R.; Raunser, Stefan; Mougous, Joseph D.

    2015-10-08

    Type VI secretion (T6S) influences the composition of microbial communities by catalyzing the delivery of toxins between adjacent bacterial cells. Here, we demonstrate that a T6S integral membrane toxin from Pseudomonas aeruginosa, Tse6, acts on target cells by degrading the universally essential dinucleotides NAD+ and NADP+. Structural analyses of Tse6 show that it resembles mono-ADP-ribosyltransferase proteins, such as diphtheria toxin, with the exception of a unique loop that both excludes proteinaceous ADP-ribose acceptors and contributes to hydrolysis. We find that entry of Tse6 into target cells requires its binding to an essential housekeeping protein, translation elongation factor Tu (EF-Tu). These proteins participate in a larger assembly that additionally directs toxin export and provides chaperone activity. Visualization of this complex by electron microscopy defines the architecture of a toxin-loaded T6S apparatus and provides mechanistic insight into intercellular membrane protein delivery between bacteria.

  10. Orbital period variations of the eclipsing binaries TU Cnc, VZ Leo, and OS Ori

    Science.gov (United States)

    Khaliullina, A. I.

    2017-10-01

    Variations of the orbital periods of the eclipsing binaries TU Cnc, VZ Leo, and OS Ori are analyzed. Secular period decreases were earlier believed to occur in these systems. It is demonstrated that the period variations of TU Cnc can be represented using the light-time effect corresponding to the orbital motion of the eclipsing binary with a period of 78.6 years around the center ofmass of the triple system, with the mass of the third body being M 3 > 0.82 M ⊙. With the same accuracy, the period variations of VZ Leo and OS Ori can be represented either solely using the light-time effect, or a superposition of a secular period decrease and the light-time effect. For VZ Leo, the period of the long-term orbit is 63.8 years in the former case and 67.9 years in the latter case. Similar masses for the third body are indicated in both cases: M 3 > 0.55 M ⊙ and M 3 > 0.61 M ⊙. For OS Ori, the period of the long-term orbit is 46 years and M 3 > 0.5 M ⊙ in the former case, and the period is 36 years and M 3 > 0.6 M ⊙ in the latter case.

  11. Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Atsushi Kaneko

    2013-01-01

    Full Text Available Purpose. Crohn's disease (CD and ulcerative colitis (UC, the two major forms of inflammatory bowel disease (IBD, have histopathologically and immunologically different characteristics. We previously reported that a traditional Japanese medicine, daikenchuto (TU-100, ameliorated a trinitrobenzenesulfonic acid- (TNBS- induced type-1 model colitis exhibiting histopathological features of CD through adrenomedullin (ADM enhancement. Our current aims were to examine whether TU-100 ameliorates a type-2 model colitis that histologically resembles UC and identify the active ingredients. Methods. TU-100 was administered orally to mice with oxazolone- (OXN- induced type-2 model colitis. The morbidity was evaluated by body weight loss and the macroscopic score of colonic lesions. ADM was quantified using an EIA kit. Results. TU-100 prevented weight loss and colon ulceration. ADM production by intestinal epithelial cells was increased by TU-100 addition. Screening to identify active ingredients showed that [6]-shogaol and hydroxy α-sanshool enhanced ADM production. Conclusions. TU-100 exerted a protective effect in OXN-induced type-2 model colitis, indicating that TU-100 may be a beneficial agent for treatment of UC.

  12. The YvfTU Two-component System is involved in plcR expression in Bacillus cereus

    NARCIS (Netherlands)

    Brillard, Julien; Susanna, Kim; Michaud, Caroline; Dargaignaratz, Claire; Gohar, Michel; Nielsen-Leroux, Christina; Ramarao, Nalini; Kolsto, Anne-Brit; Nguyen-The, Christophe; Lereclus, Didier; Broussolle, Veronique

    2008-01-01

    Background: Most extracellular virulence factors produced by Bacillus cereus are regulated by the pleiotropic transcriptional activator PlcR. Among strains belonging to the B. cereus group, the plcR gene is always located in the vicinity of genes encoding the YvfTU two-component system. The putative

  13. Mitochondrial translation factors of Trypanosoma brucei: elongation factor-Tu has a unique subdomain that is essential for its function

    Czech Academy of Sciences Publication Activity Database

    Cristodero, M.; Mani, J.; Oeljeklaus, S.; Aeberhard, L.; Hashimi, Hassan; Ramrath, D.J.F.; Lukeš, Julius; Warscheid, B.; Schneider, A.

    2013-01-01

    Roč. 90, č. 4 (2013), s. 744-755 ISSN 0950-382X R&D Projects: GA ČR GAP305/12/2261 Institutional support: RVO:60077344 Keywords : mitochondrial translation * Trypanosoma brucei * EF-Tu Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 5.026, year: 2013

  14. Crosslinking of tRNA containing a long extra arm to elongation factor Tu by trans-diamminedichloroplatinum(II)

    DEFF Research Database (Denmark)

    Rasmussen, Nils-Jørgen; Wikman, Friedrik; Clark, Brian F. C.

    1990-01-01

    A tRNA containing a long extra arm, namely E. coli tRNA1Leu has been crosslinked to elongation factor Tu, with the crosslinking reagent trans-diamminedichloroplatinum(II). The nucleotide involved in the crosslinking was identified to be a guanosine in the variable region at position 47F or 47G....

  15. The surface-associated elongation factor Tu is concealed for antibody binding on viable pneumococci and meningococci

    Czech Academy of Sciences Publication Activity Database

    Kolberg, J.; Hammerschmidt, S.; Frank, R.; Jonák, Jiří; Šanderová, Hana; Aase, A.

    2008-01-01

    Roč. 53, č. 2 (2008), s. 222-230 ISSN 0928-8244 R&D Projects: GA AV ČR KJB500520503 Institutional research plan: CEZ:AV0Z50520514; CEZ:AV0Z50200510 Keywords : Streptococcus pneumoniae * Neisseria meningitidis * elongation factor EF-Tu Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.972, year: 2008

  16. Le politique, opérateur de la construction des savoirs géographiques modernes: l'exemple des voyages d'Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Laura Péaud

    2011-10-01

    Full Text Available RésuméA la charnière du XVIIIème et du XIXème siècle, Alexander von Humboldt réalise une série de voyages scientifiques et géographiques en Europe, en Amérique et en Asie. Connus en grande partie par sa très riche correspondance, ces voyages sont tous marqués par la présence et l’intervention d’acteurs du monde politique européen. Par leur soutien financier, matériel et moral, ainsi que par leur délimitation spatiale, temporelle voire thématique des objets des expéditions, ceux-ci structurent pratiquement et intellectuellement le déroulement des expéditions humboldtiennes.Aux alentours du moment 1800, la géographie se trouve alors engagée dans un mouvement de construction disciplinaire, questionnant ses objets, ses méthodes et ses pratiques. Inséré dans ce processus, le voyage constitue un enjeu identitaire fort de l’élaboration et de la définition des savoirs géographiques modernes. La participation des acteurs politiques dans les voyages interroge leur rôle d’opérateurs de la fabrique scientifique. A partir de l’exemple humboldtien, dans une optique d’histoire et d’épistémologie de la géographie, cet article propose d’engager une analyse relationnelle du couple géographie/politique.ZusammenfassungZwischen 1799 und 1829 unternahm Alexander von Humboldt eine Reihe wissenschaftlicher Reisen durch Europa, Amerika und Asien. Nicht zuletzt dank der überlieferten Korrespondenz sind die Reisen sehr gut dokumentiert: Politische Akteure spielten eine große Rolle bei der Planung und Umsetzung der Reisen. So unterstützten sie Humboldts Reisen sowohl mit materiellen als auch ideellen Mitteln. Mitunter nahmen sie Einfluss auf Routen sowie auf Dauer und thematische Ausrichtung der Reisen. Dies strukturierte die Humboldt’schen Reisen intellektuell und in ihrer praktischen Umsetzung.Um 1800 bildete sich die Geographie zur wissenschaftlichen Disziplin heraus, ihre Forschungsgegenstände, Methoden und

  17. A guidelines handbook for GPR surveys in tunnels: a COST Action TU1208 contribution

    Science.gov (United States)

    Bianchini Ciampoli, Luca; Alani, Amir M.; Pajewski, Lara; Benedetto, Andrea; Loizos, Andreas; Tosti, Fabio

    2016-04-01

    A significant open issue concerning the reliability of geophysical methods and in particular of ground penetrating radar (GPR), both in research and professional context, is a general lack of international standards. This is a major problem to be faced, in order to gain scientific strictness for the GPR practices, and to easily extend to the international community the results achieved within the area of single virtuous countries. Producing international guidelines can represent an important step forward, in this sense. In the memorandum of understanding of the COST Action TU1208 is clearly stated that one of the main purposes of the Action is the "development of innovative protocols and guidelines which will be published in a handbook and constitute a basis for European Standards, for an effective GPR application in CE tasks; safety, economic and financial criteria will be integrated within the protocols". Of course this is not a simple task to be accomplished. Firstly, survey procedures are highly dependent on the objective of the survey itself. On the basis of the objective of each geophysical test, the GPR system, the antenna configuration, and even the processing procedures may change. Besides, these procedures are also influenced by the environmental conditions in which the tests are performed. This affects several aspects spanning from hardware to software, but including, for instance, also safety issues. Due to these reasons, one of the main goal of the COST Action TU1208 is the development of several guidelines related to the main applications of GPR in the field of civil engineering. In this work, the structure of a guidelines handbook for GPR activities in tunnels is outlined. In the first sections, the principal references in the field are provided, and the most common GPR equipment and complementary technologies are described. Subsequently, the survey methodologies are explained. Particular attention is paid to the preliminary activities to be carried

  18. “En tu casa o en la mía”: la entrevista como Infoentretenimiento

    Directory of Open Access Journals (Sweden)

    Marián Alonso González

    2016-11-01

    Full Text Available La lucha por la audiencia ha provocado una oferta de contenidos espectacular donde las fronteras de los géneros se han difuminado, dando lugar a nuevos formatos televisivos híbridos que han revitalizado la entrevista como un género de infoentretenimiento. A lo largo de este artículo analizamos el programa “En tu casa o en la mía”, un nuevo formato de entrevista de personalidad que aúna información y entretenimiento con claros elementos cercanos al infoshow. Estudiamos el producto mediático atendiendo a la narrativa, el tratamiento, la estructura y la técnica empleada con el fin de describir los elementos que hacen de este espacio un ejemplo de hibridación de géneros en el contexto televisivo actual.

  19. “En tu casa o en la mía’: the interview as infotainment

    Directory of Open Access Journals (Sweden)

    Marián Alonso González

    2016-11-01

    Full Text Available The fight for viewers has led to a spectacular range of television content on offer where boundaries of genres have disappeared giving rise to new formats of hybrid television programmes. This has given a new lease of life to interviews as a genre of infotainment. The present article analyses the programme ‘En tu casa o en la mía’, a new type of interview of famous personalities which combines information and entertainment with elements that are very similar to the info-show. We shall embark on a study of this media product, its narrative, treatment, structure and the technique used so as to describe the elements that make it an example of gender hybridization in today’s television programmes.

  20. Housing for the poor: Implementation and impact of Tu Casa program in Tijuana

    Directory of Open Access Journals (Sweden)

    Ana Elizabeth Jardón Hernández

    2009-01-01

    Full Text Available This study assesses the operation and some major results of most important federal housing program focus on households in poverty situation, with particular emphasis on their instrumentation process and impacts in Tijuana’s housing problem for poor families. The exam aims to analyses the design changes of the program that forced its transformation from Vivah to Tu Casa, and the operational difficulties for a proper implementation in an urban context, as well as its limited impact for solving popular housing needs. It also seeks to weigh the importance of government subsidies to acquire or improve housing, in their progressive modality, as an alternative for social segments excluded from any other public or private financing option.

  1. Joint efforts to harmonize sound insulation descriptors and classification schemes in Europe (COST TU0901)

    DEFF Research Database (Denmark)

    Rasmussen, Birgit

    2010-01-01

    Sound insulation descriptors, regulatory requirements and classification schemes in Europe represent a high degree of diversity. One implication is very little exchange of experience of housing design and construction details for different levels of sound insulation; another is trade barriers...... for building systems and products. Unfortunately, there is evidence for a development in the "wrong" direction. For example, sound classification schemes for dwellings exist in nine countries. There is no sign on increasing harmonization, rather the contrary, as more countries are preparing proposals with new......, new housing must meet the needs of the people and offer comfort. Also for existing housing, sound insulation aspects should be taken into account, when renovating housing; otherwise the renovation is not “sustainable”. A joint European Action, COST TU0901 "Integrating and Harmonizing Sound Insulation...

  2. Mapping Escherichia coli elongation factor Tu residues involved in binding of aminoacyl-tRNA

    DEFF Research Database (Denmark)

    Wiborg, Ove; Andersen, C; Knudsen, Charlotte Rohde

    1996-01-01

    Two residues of Escherichia coli elongation factor Tu involved in binding of aminoacyl-tRNA were identified and subjected to mutational analysis. Lys-89 and Asn-90 were each replaced by either Ala or Glu. The four single mutants were denoted K89A, K89E, N90A, and N90E, respectively. The mutants......-tRNA, which suggested an important role of Lys-89 and Asn-90 in tRNA binding. Furthermore, our results indicate helix B to be an important target site for nucleotide exchange factor EF-Ts. Also the mutants His-66 to Ala and His-118 to either Ala or Glu were characterized in an in vitro translation assay...

  3. An integrable coupling family of Merola-Ragnisco-Tu lattice systems, its Hamiltonian structure and related nonisospectral integrable lattice family

    International Nuclear Information System (INIS)

    Xu Xixiang

    2010-01-01

    An integrable coupling family of Merola-Ragnisco-Tu lattice systems is derived from a four-by-four matrix spectral problem. The Hamiltonian structure of the resulting integrable coupling family is established by the discrete variational identity. Each lattice system in the resulting integrable coupling family is proved to be integrable discrete Hamiltonian system in Liouville sense. Ultimately, a nonisospectral integrable lattice family associated with the resulting integrable lattice family is constructed through discrete zero curvature representation.

  4. Thermostability of Multidomain Proteins: Elongation Factors EF-Tu from Escherichia coli and Bacillus stearothermophilus and Their Chimeric Forms

    Czech Academy of Sciences Publication Activity Database

    Šanderová, Hana; Hůlková, Marta; Maloň, Petr; Kepková, M.; Jonák, Jiří

    2004-01-01

    Roč. 13, č. 1 (2004), s. 89-99 ISSN 0961-8368 R&D Projects: GA AV ČR IPP1050128; GA ČR GA204/98/0863; GA ČR GA303/02/0689 Institutional research plan: CEZ:AV0Z4055905; CEZ:AV0Z5052915 Keywords : elongation factor EF-Tu, thermostability, chimeric protein Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.116, year: 2004

  5. Collaboration of the Dutch research program for radioactive waste disposal (OPERA) and TU Delft

    International Nuclear Information System (INIS)

    Bykov, D.M.; Kloosterman, J.L.

    2015-01-01

    awarded research proposals available at www.covra.nl/downloads/o pera. Building up competences and knowledge on radioactive waste management and geological disposal is an important goal of OPERA. To this end OPERA collaborates with TU Delft to develop an academic curriculum for the chair Chemistry of the Nuclear Fuel Cycle in the Master of Science Engineering. Furthermore, the results obtained in OPERA will be presented at a Summer School which is planned to be organized at the end of the Program. TU Delft educates young specialists, bachelor and master students, by research projects on geological disposal at the new actinide laboratory (U and Th). For such purpose the knowledge transfer from other OPERA partners is also foreseen, including students internships and visits of the research facilities. Reactor Institute Delft (RID) is part of the Applied Sciences faculty of TU Delft and houses the Radiation Science and Technology (RST) department. RID operates the Hoger Onderwijs Reactor (HOR), a 2 MW pool- type research reactor in an academic setting. The reactor is used as a source of neutrons and positrons for research purposes, including those of OPERA. It also provides neutrons to a variety of facilities for radioisotope production and neutron activation analysis. OPERA is financed by the Dutch Ministry of Economic Affairs and the public limited liability company Elektriciteits-Produktiemaatschappij Zuid-Nederland (EPZ) and coordinated by COVRA.

  6. Collaboration of the Dutch research program for radioactive waste disposal (OPERA) and TU Delft

    Energy Technology Data Exchange (ETDEWEB)

    Bykov, D.M.; Kloosterman, J.L. [TU Delft (Netherlands). Reactor Inst. Delft; Neeft, E.A.C.; Verhoef, E.V. [COVRA N.V., Nieuwdorp (Netherlands)

    2015-07-01

    awarded research proposals available at www.covra.nl/downloads/o pera. Building up competences and knowledge on radioactive waste management and geological disposal is an important goal of OPERA. To this end OPERA collaborates with TU Delft to develop an academic curriculum for the chair Chemistry of the Nuclear Fuel Cycle in the Master of Science Engineering. Furthermore, the results obtained in OPERA will be presented at a Summer School which is planned to be organized at the end of the Program. TU Delft educates young specialists, bachelor and master students, by research projects on geological disposal at the new actinide laboratory (U and Th). For such purpose the knowledge transfer from other OPERA partners is also foreseen, including students internships and visits of the research facilities. Reactor Institute Delft (RID) is part of the Applied Sciences faculty of TU Delft and houses the Radiation Science and Technology (RST) department. RID operates the Hoger Onderwijs Reactor (HOR), a 2 MW pool- type research reactor in an academic setting. The reactor is used as a source of neutrons and positrons for research purposes, including those of OPERA. It also provides neutrons to a variety of facilities for radioisotope production and neutron activation analysis. OPERA is financed by the Dutch Ministry of Economic Affairs and the public limited liability company Elektriciteits-Produktiemaatschappij Zuid-Nederland (EPZ) and coordinated by COVRA.

  7. Development of SAP-DoA techniques for GPR data processing within COST Action TU1208

    Science.gov (United States)

    Meschino, Simone; Pajewski, Lara; Marciniak, Marian

    2016-04-01

    This work focuses on the use of Sub-Array Processing (SAP) and Direction of Arrival (DoA) approaches for the processing of Ground-Penetrating Radar data, with the purpose of locating metal scatterers embedded in concrete or buried in the ground. Research activities have been carried out during two Short-Term Scientific Missions (STSMs) funded by the COST (European COoperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" in May 2015 and January 2016. In applications involving smart antennas and in the presence of several transmitters operating simultaneously, it is important for a receiving array to be able to estimate the Direction of Arrival (DoA) of the incoming signals, in order to decipher how many emitters are present and predict their positions. A number of methods have been devised for DoA estimation: the MUltiple SIgnal Classification (MUSIC) and Estimation of Signal Parameters via Rotational Invariance Technique (ESPRIT) are amongst the most popular ones [1]. In the scenario considered by us, the electromagnetic sources are the currents induced on metal elements embedded in concrete or buried in the ground. GPR radargrams are processed, to estimate the DoAs of the electric field back-scattered by the sought targets. In order to work in near-field conditions, a sub-array processing (SAP) approach is adopted: the radargram is partitioned in sub-radargrams composed of few A-scans each, the dominant DoA is predicted for each sub-radargram. The estimated angles are triangulated, obtaining a set of crossings with intersections condensed around object locations. This pattern is filtered, in order to remove a noisy background of unwanted crossings, and is processed by applying the statistical procedure described in [2]. We tested our approach on synthetic GPR radargrams, obtained by using the freeware simulator gprMax implementing the Finite-Difference Time-Domain method [3]. In particular, we worked with

  8. DeitY-TU face database: its design, multiple camera capturing, characteristics, and evaluation

    Science.gov (United States)

    Bhowmik, Mrinal Kanti; Saha, Kankan; Saha, Priya; Bhattacharjee, Debotosh

    2014-10-01

    The development of the latest face databases is providing researchers different and realistic problems that play an important role in the development of efficient algorithms for solving the difficulties during automatic recognition of human faces. This paper presents the creation of a new visual face database, named the Department of Electronics and Information Technology-Tripura University (DeitY-TU) face database. It contains face images of 524 persons belonging to different nontribes and Mongolian tribes of north-east India, with their anthropometric measurements for identification. Database images are captured within a room with controlled variations in illumination, expression, and pose along with variability in age, gender, accessories, make-up, and partial occlusion. Each image contains the combined primary challenges of face recognition, i.e., illumination, expression, and pose. This database also represents some new features: soft biometric traits such as mole, freckle, scar, etc., and facial anthropometric variations that may be helpful for researchers for biometric recognition. It also gives an equivalent study of the existing two-dimensional face image databases. The database has been tested using two baseline algorithms: linear discriminant analysis and principal component analysis, which may be used by other researchers as the control algorithm performance score.

  9. Electromagnetic simulators for Ground Penetrating Radar applications developed in COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Giannopoulos, Antonios; Warren, Craig; Antonijevic, Sinisa; Doric, Vicko; Poljak, Dragan

    2017-04-01

    Founded in 1971, COST (European COoperation in Science and Technology) is the first and widest European framework for the transnational coordination of research activities. It operates through Actions, science and technology networks with a duration of four years. The main objective of the COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" (4 April 2013 - 3 October 2017) is to exchange and increase knowledge and experience on Ground-Penetrating Radar (GPR) techniques in civil engineering, whilst promoting in Europe a wider use of this technique. Research activities carried out in TU1208 include all aspects of the GPR technology and methodology: design, realization and testing of radar systems and antennas; development and testing of surveying procedures for the monitoring and inspection of structures; integration of GPR with other non-destructive testing approaches; advancement of electromagnetic-modelling, inversion and data-processing techniques for radargram analysis and interpretation. GPR radargrams often have no resemblance to the subsurface or structures over which the profiles were recorded. Various factors, including the innate design of the survey equipment and the complexity of electromagnetic propagation in composite scenarios, can disguise complex structures recorded on reflection profiles. Electromagnetic simulators can help to understand how target structures get translated into radargrams. They can show the limitations of GPR technique, highlight its capabilities, and support the user in understanding where and in what environment GPR can be effectively used. Furthermore, electromagnetic modelling can aid the choice of the most proper GPR equipment for a survey, facilitate the interpretation of complex datasets and be used for the design of new antennas. Electromagnetic simulators can be employed to produce synthetic radargrams with the purposes of testing new data-processing, imaging and inversion algorithms, or assess

  10. Planeando Tu Vida: sex and family life education: fundamentals of development, implementation, and evaluation.

    Science.gov (United States)

    Pick De Weiss, S; Givaudan, M; Givaudan, S

    1993-01-01

    Misinformation about sexuality, reproduction, and contraception is widespread among Mexican adolescents and existing sex education programs have been limited in both scope and availability. To address this situation, the Instituto Mexicano de Investigacion de Familia y Poblacion (IMIFAP) designed a comprehensive sex education program based on data gathered in a 1986 diagnostic survey of 865 adolescents 12-19 years of age and interviews with 365 pregnant adolescents. As part of this preliminary research, one group of teens was exposed to a traditional sex education course while another participated in a program that used participatory learning techniques and emphasized communication skills, assertiveness training, value clarification, peer support, and decision making processes. The latter, more effective approach served as the basis for design of a course, Planeando Tu Vida. Operational evaluations of this course conducted at completion and four and eight months later indicated significant increases in knowledge about contraception, but no effect on age at first intercourse. On the other hand, adolescent males who took the course before onset of sexual activity were significantly more likely to use contraceptives at first intercourse than those in traditional courses. This finding underscores the importance of early initiation of sex education programs. To date, the curriculum has been used in over 100 public and private schools, reaching more than 30,000 adolescents. IMIFAP has since developed more than 70 additional health education course guides aimed at children from preschool through high school, all of which emphasize a participatory approach to learning.

  11. [Control of Aedes aegypti breeding sites with the program Recicla por tu bienestar in Merida, Mexico].

    Science.gov (United States)

    Barrera-Pérez, Mario A; Pavía-Ruz, Norma; Mendoza-Mezquita, Jorge Eduardo; Torres-Arcila, Nerio; Hernández-Hernández, Ramón; Castro-Gamboa, Francisco; Geded-Moreno, Eduardo; Cohuo-Rodríguez, Azael; Medina-Barreiro, Anuar; Koyoc-Cardeña, Edgar; Gómez-Dantés, Héctor; Kroeger, Axel; Vázquez-Prokopec, Gonzalo; Manrique-Saide, Pablo

    2015-01-01

    To determine the importance of Ae. aegypti breeding-sites in Merida;to evaluate the impact of Recicla por tu bienestar (RxB, a recycling program) on the reduction of breeding sites and the perception of participants. The relative importance for pupae production of the different types of breeding-sites was determined. Pre-and post-RxB entomological surveys were performed in participant neighborhoods to evaluate the impact on total containers and positive breeding-sites. A survey on the perception of participating people about dengue prevention and control and RxB was applied. Buckets/pots and "small diverse items" were the most important breeding-sites. RxB had a significant impact in the reduction of total containers (IRR = 0.74), positive containers (IRR = 0.33) and the risk of a house being positive for Ae. aegypti (OR = 0.41). All the interviewed participants referred RxB as needed and most consider it useful. RxB should be considered as a good practice for the dengue vector control.

  12. Establishment and characterization of a novel uterine carcinosarcoma cell line, TU-ECS-1, with mutations of TP53 and KRAS.

    Science.gov (United States)

    Chiba, Yohei; Sato, Seiya; Itamochi, Hiroaki; Suga, Yasuko; Fukagawa, Tomoyuki; Oumi, Nao; Oishi, Tetsuro; Harada, Tasuku; Sugai, Tamotsu; Sugiyama, Toru

    2017-04-01

    A new human uterine carcinosarcoma (UCS) cell line, TU-ECS-1, was established and characterized. The morphological appearance of the cultured cells was an insular of epithelial-like cells arranged in the form of a jigsaw puzzle and mesenchymal-like cells with a spindle-shaped or fibroblast-like morphology. A relatively high proliferation rate was observed with a doubling time of 18.2 h. The chromosome number ranged from 44 to 49 and had an extra chromosome 12 (trisomy 12). The respective half-maximal inhibitory concentrations of cisplatin, paclitaxel, and doxorubicin were 2.9 µM, 154 nM, and 219 ng/mL, respectively. Mutational analysis revealed that TU-ECS-1 cells have mutations of TP53 in exons 4, 6, and 8 and of KRAS at codon 12 (G12D) in exon 2, which is a mutation hot spot on this gene. Western blot analysis showed that p53 protein was overexpressed in TU-ECS-1 cells. Immunostaining of the cultured cells and in vivo tumors showed that the TU-ECS-1 cells and xenografts were positive for epithelial marker cytokeratin AE1/3 and mesenchymal marker vimentin. These results suggested that TU-ECS-1 cells might have both epithelial and mesenchymal characteristics. This cell line may be useful to study the carcinogenesis of UCS and contribute to the development of novel treatment strategies.

  13. Le réseau d'échanges des savoirs de belleville e ménilmontant: uma discussão sobre associativismo e reciprocidade no mundo contemporâneo

    Directory of Open Access Journals (Sweden)

    Laura Graziela Gomes

    2001-12-01

    Full Text Available O presente artigo tem como objetivo tecer algumas reflexões sobre os modos de apropriação locais de uma forma associativa francesa específica - le réseau d' échanges des savoirs - de Belleville e Ménilmontant, dois quartiers populares, sediados no leste parisiense. A partir de minha experiência como participante do reseau, observações e conversas com os demais participantes, conclui que, basicamente, tratam-se de dois modos: o primeiro, relativo à produção de localidade, da condição de pertença dos moradores do quartier; o segundo, relativo à produção de capital social, traduzido em confiança e, por sua vez, formas de cooperação. O importante a ser ressaltado é que esses dois modos de apropriação não são exclusivos, ambos convivem, fundem- se e se interpenetram.

  14. COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar": ongoing research activities and third-year results

    Science.gov (United States)

    Pajewski, Lara; Benedetto, Andrea; Loizos, Andreas; Tosti, Fabio

    2016-04-01

    This work aims at disseminating the ongoing research activities and third-year results of the COST (European COoperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar." About 350 experts are participating to the Action, from 28 COST Countries (Austria, Belgium, Croatia, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Ireland, Italy, Latvia, Malta, Macedonia, The Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, United Kingdom), and from Albania, Armenia, Australia, Colombia, Egypt, Hong Kong, Jordan, Israel, Philippines, Russia, Rwanda, Ukraine, and United States of America. In September 2014, TU1208 has been recognised among the running Actions as "COST Success Story" ("The Cities of Tomorrow: The Challenges of Horizon 2020," September 17-19, 2014, Torino, IT - A COST strategic workshop on the development and needs of the European cities). The principal goal of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of GPR techniques in civil engineering, whilst simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. Moreover, the Action is oriented to the following specific objectives and expected deliverables: (i) coordinating European scientists to highlight problems, merits and limits of current GPR systems; (ii) developing innovative protocols and guidelines, which will be published in a handbook and constitute a basis for European standards, for an effective GPR application in civil- engineering tasks; safety, economic and financial criteria will be integrated within the protocols; (iii) integrating competences for the improvement and merging of electromagnetic scattering techniques and of data- processing techniques; this will lead to a novel freeware tool for the localization of

  15. Elongation Factor Tu and Heat Shock Protein 70 Are Membrane-Associated Proteins from Mycoplasma ovipneumoniae Capable of Inducing Strong Immune Response in Mice.

    Science.gov (United States)

    Jiang, Fei; He, Jinyan; Navarro-Alvarez, Nalu; Xu, Jian; Li, Xia; Li, Peng; Wu, Wenxue

    2016-01-01

    Chronic non-progressive pneumonia, a disease that has become a worldwide epidemic has caused considerable loss to sheep industry. Mycoplasma ovipneumoniae (M. ovipneumoniae) is the causative agent of interstitial pneumonia in sheep, goat and bighorn. We here have identified by immunogold and immunoblotting that elongation factor Tu (EF-Tu) and heat shock protein 70 (HSP 70) are membrane-associated proteins on M. ovipneumonaiea. We have evaluated the humoral and cellular immune responses in vivo by immunizing BALB/c mice with both purified recombinant proteins rEF-Tu and rHSP70. The sera of both rEF-Tu and rHSP70 treated BALB/c mice demonstrated increased levels of IgG, IFN-γ, TNF-α, IL-12(p70), IL-4, IL-5 and IL-6. In addition, ELISPOT assay showed significant increase in IFN-γ+ secreting lymphocytes in the rHSP70 group when compared to other groups. Collectively our study reveals that rHSP70 induces a significantly better cellular immune response in mice, and may act as a Th1 cytokine-like adjuvant in immune response induction. Finally, growth inhibition test (GIT) of M. ovipneumoniae strain Y98 showed that sera from rHSP70 or rEF-Tu-immunized mice inhibited in vitro growth of M. ovipneumoniae. Our data strongly suggest that EF-Tu and HSP70 of M. ovipneumoniae are membrane-associated proteins capable of inducing antibody production, and cytokine secretion. Therefore, these two proteins may be potential candidates for vaccine development against M. ovipneumoniae infection in sheep.

  16. Elongation Factor Tu and Heat Shock Protein 70 Are Membrane-Associated Proteins from Mycoplasma ovipneumoniae Capable of Inducing Strong Immune Response in Mice.

    Directory of Open Access Journals (Sweden)

    Fei Jiang

    Full Text Available Chronic non-progressive pneumonia, a disease that has become a worldwide epidemic has caused considerable loss to sheep industry. Mycoplasma ovipneumoniae (M. ovipneumoniae is the causative agent of interstitial pneumonia in sheep, goat and bighorn. We here have identified by immunogold and immunoblotting that elongation factor Tu (EF-Tu and heat shock protein 70 (HSP 70 are membrane-associated proteins on M. ovipneumonaiea. We have evaluated the humoral and cellular immune responses in vivo by immunizing BALB/c mice with both purified recombinant proteins rEF-Tu and rHSP70. The sera of both rEF-Tu and rHSP70 treated BALB/c mice demonstrated increased levels of IgG, IFN-γ, TNF-α, IL-12(p70, IL-4, IL-5 and IL-6. In addition, ELISPOT assay showed significant increase in IFN-γ+ secreting lymphocytes in the rHSP70 group when compared to other groups. Collectively our study reveals that rHSP70 induces a significantly better cellular immune response in mice, and may act as a Th1 cytokine-like adjuvant in immune response induction. Finally, growth inhibition test (GIT of M. ovipneumoniae strain Y98 showed that sera from rHSP70 or rEF-Tu-immunized mice inhibited in vitro growth of M. ovipneumoniae. Our data strongly suggest that EF-Tu and HSP70 of M. ovipneumoniae are membrane-associated proteins capable of inducing antibody production, and cytokine secretion. Therefore, these two proteins may be potential candidates for vaccine development against M. ovipneumoniae infection in sheep.

  17. COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar:" ongoing research activities and mid-term results

    Science.gov (United States)

    Pajewski, Lara; Benedetto, Andrea; Loizos, Andreas; Slob, Evert; Tosti, Fabio

    2015-04-01

    This work aims at presenting the ongoing activities and mid-term results of the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar.' Almost three hundreds experts are participating to the Action, from 28 COST Countries (Austria, Belgium, Croatia, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Ireland, Italy, Latvia, Malta, Macedonia, The Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, United Kingdom), and from Albania, Armenia, Australia, Egypt, Hong Kong, Jordan, Israel, Philippines, Russia, Rwanda, Ukraine, and United States of America. In September 2014, TU1208 has been praised among the running Actions as 'COST Success Story' ('The Cities of Tomorrow: The Challenges of Horizon 2020,' September 17-19, 2014, Torino, IT - A COST strategic workshop on the development and needs of the European cities). The principal goal of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of GPR techniques in civil engineering, whilst simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. Moreover, the Action is oriented to the following specific objectives and expected deliverables: (i) coordinating European scientists to highlight problems, merits and limits of current GPR systems; (ii) developing innovative protocols and guidelines, which will be published in a handbook and constitute a basis for European standards, for an effective GPR application in civil- engineering tasks; safety, economic and financial criteria will be integrated within the protocols; (iii) integrating competences for the improvement and merging of electromagnetic scattering techniques and of data- processing techniques; this will lead to a novel freeware tool for the localization of buried objects

  18. Combination of GPR with other NDT techniques in different fields of application - COST Action TU1208

    Science.gov (United States)

    Solla, Mercedes; Pérez-Gracia, Vega; Fontul, Simona; Santos-Assunçao, Sonia; Kucukdemirci, Melda

    2017-04-01

    common geophysical methods used for archaeological prospection (GPR and magnetometry). Regarding cultural heritage, an example in Barcelona (Spain) of the assessment of masonry structural elements, with embedded metallic targets, is included. Seismic tomography and 3D GPR imaging are applied, both supported with endoscopy. The results highlight the most affected areas of the structure and the existence of corroded metallic elements as consequence of humidity. Finally, two case studies support the importance of combining data in geological applications. Firstly, GPR and Electrical Resistivity Tomography (ERT) were combined for the analysis of the littoral drift and the tidal range affecting the transport of sediments in costal environments, and more particularly in O Adro Beach, in Vigo (Spain) that had been subjected to extension activities during the last decades. Secondly, the combination Multibeam Sonar and GPR data is presented for the study of a lake, which is an abandoned kaolin mine. Thus, it was possible to analyze the column of water in all the extension of the lake, while differentiating layers of lacustrine deposits and kaolin rock formations in subsurface. This work represents a contribution to the COST (European Cooperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar". The authors thank COST for funding the Action TU1208.

  19. I Passiuna tu Christù - Rito e teatro di una cantica popolare della Grecìa Salentina

    OpenAIRE

    Diana Costa

    2012-01-01

    Abstract – IT Questo articolo si basa sugli esiti di una ricerca di campo condotta nei paesi della Grecìa Salentina,una zona del basso Salento, dove si riscontra una peculiare modalità di esecuzione della cantica popolare grìca conosciuta come I Passiuna tu Christù (La Passione di Cristo). Attorno alla metà degli anni ´90 del ´900 la tradizione della cantica è stata oggetto di un prezioso recupero, fondato sulla memoria e disponibilità di alcuni anziani cantori, che l’ha riportata in vita dop...

  20. Modular programming for tuberculosis control, the "AuTuMN" platform.

    Science.gov (United States)

    Trauer, James McCracken; Ragonnet, Romain; Doan, Tan Nhut; McBryde, Emma Sue

    2017-08-07

    Tuberculosis (TB) is now the world's leading infectious killer and major programmatic advances will be needed if we are to meet the ambitious new End TB Targets. Although mathematical models are powerful tools for TB control, such models must be flexible enough to capture the complexity and heterogeneity of the global TB epidemic. This includes simulating a disease that affects age groups and other risk groups differently, has varying levels of infectiousness depending upon the organ involved and varying outcomes from treatment depending on the drug resistance pattern of the infecting strain. We adopted sound basic principles of software engineering to develop a modular software platform for simulation of TB control interventions ("AuTuMN"). These included object-oriented programming, logical linkage between modules and consistency of code syntax and variable naming. The underlying transmission dynamic model incorporates optional stratification by age, risk group, strain and organ involvement, while our approach to simulating time-variant programmatic parameters better captures the historical progression of the epidemic. An economic model is overlaid upon this epidemiological model which facilitates comparison between new and existing technologies. A "Model runner" module allows for predictions of future disease burden trajectories under alternative scenario situations, as well as uncertainty, automatic calibration, cost-effectiveness and optimisation. The model has now been used to guide TB control strategies across a range of settings and countries, with our modular approach enabling repeated application of the tool without the need for extensive modification for each application. The modular construction of the platform minimises errors, enhances readability and collaboration between multiple programmers and enables rapid adaptation to answer questions in a broad range of contexts without the need for extensive re-programming. Such features are particularly

  1. Bacillus anthracis Prolyl 4-Hydroxylase Interacts with and Modifies Elongation Factor Tu

    Energy Technology Data Exchange (ETDEWEB)

    Schnicker, Nicholas J. [Department; Razzaghi, Mortezaali [Department; Guha Thakurta, Sanjukta [Department; Chakravarthy, Srinivas [Biophysics; Dey, Mishtu [Department

    2017-10-17

    Prolyl hydroxylation is a very common post-translational modification and plays many roles in eukaryotes such as collagen stabilization, hypoxia sensing, and controlling protein transcription and translation. There is a growing body of evidence that suggests that prokaryotes contain prolyl 4-hydroxylases (P4Hs) homologous to the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes that act on elongation factor Tu (EFTu) and are likely involved in the regulation of bacterial translation. Recent biochemical and structural studies with a PHD from Pseudomonas putida (PPHD) determined that it forms a complex with EFTu and hydroxylates a prolyl residue of EFTu. Moreover, while animal, plant, and viral P4Hs act on peptidyl proline, most prokaryotic P4Hs have been known to target free l-proline; the exceptions include PPHD and a P4H from Bacillus anthracis (BaP4H) that modifies collagen-like proline-rich peptides. Here we use biophysical and mass spectrometric methods to demonstrate that BaP4H recognizes full-length BaEFTu and a BaEFTu 9-mer peptide for site-specific proline hydroxylation. Using size-exclusion chromatography coupled small-angle X-ray scattering (SEC–SAXS) and binding studies, we determined that BaP4H forms a 1:1 heterodimeric complex with BaEFTu. The SEC–SAXS studies reveal dissociation of BaP4H dimeric subunits upon interaction with BaEFTu. While BaP4H is unusual within bacteria in that it is structurally and functionally similar to the animal PHDs and collagen P4Hs, respectively, this work provides further evidence of its promiscuous substrate recognition. It is possible that the enzyme might have evolved to hydroxylate a universally conserved protein in prokaryotes, similar to the PHDs, and implies a functional role in B. anthracis.

  2. Structure of the E. coli ribosome-EF-Tu complex at cryo-EM.

    Science.gov (United States)

    Fischer, Niels; Neumann, Piotr; Konevega, Andrey L; Bock, Lars V; Ficner, Ralf; Rodnina, Marina V; Stark, Holger

    2015-04-23

    Single particle electron cryomicroscopy (cryo-EM) has recently made significant progress in high-resolution structure determination of macromolecular complexes due to improvements in electron microscopic instrumentation and computational image analysis. However, cryo-EM structures can be highly non-uniform in local resolution and all structures available to date have been limited to resolutions above 3 Å. Here we present the cryo-EM structure of the 70S ribosome from Escherichia coli in complex with elongation factor Tu, aminoacyl-tRNA and the antibiotic kirromycin at 2.65-2.9 Å resolution using spherical aberration (Cs)-corrected cryo-EM. Overall, the cryo-EM reconstruction at 2.9 Å resolution is comparable to the best-resolved X-ray structure of the E. coli 70S ribosome (2.8 Å), but provides more detailed information (2.65 Å) at the functionally important ribosomal core. The cryo-EM map elucidates for the first time the structure of all 35 rRNA modifications in the bacterial ribosome, explaining their roles in fine-tuning ribosome structure and function and modulating the action of antibiotics. We also obtained atomic models for flexible parts of the ribosome such as ribosomal proteins L9 and L31. The refined cryo-EM-based model presents the currently most complete high-resolution structure of the E. coli ribosome, which demonstrates the power of cryo-EM in structure determination of large and dynamic macromolecular complexes.

  3. TU1208 Open Database of Radargrams: The Dataset of the IFSTTAR Geophysical Test Site

    Directory of Open Access Journals (Sweden)

    Xavier Dérobert

    2018-03-01

    Full Text Available This paper aims to present a wide dataset of ground penetrating radar (GPR profiles recorded on a full-size geophysical test site, in Nantes (France. The geophysical test site was conceived to reproduce objects and obstacles commonly met in the urban subsurface, in a completely controlled environment; since the design phase, the site was especially adapted to the context of radar-based techniques. After a detailed description of the test site and its building process, the GPR profiles included in the dataset are presented and commented on. Overall, 67 profiles were recorded along eleven parallel lines crossing the test site in the transverse direction; three pulsed radar systems were used to perform the measurements, manufactured by different producers and equipped with various antennas having central frequencies from 200 MHz to 900 MHz. An archive containing all profiles (raw data is enclosed to this paper as supplementary material. This dataset is the core part of the Open Database of Radargrams initiative of COST (European Cooperation in Science and Technology Action TU1208 “Civil engineering applications of Ground Penetrating Radar”. The idea beyond such initiative is to share with the scientific community a selection of interesting and reliable GPR responses, to enable an effective benchmark for direct and inverse electromagnetic approaches, imaging methods and signal processing algorithms. We hope that the dataset presented in this paper will be enriched by the contributions of further users in the future, who will visit the test site and acquire new data with their GPR systems. Moreover, we hope that the dataset will be made alive by researchers who will perform advanced analyses of the profiles, measure the electromagnetic characteristics of the host materials, contribute with synthetic radargrams obtained by modeling the site with electromagnetic simulators, and more in general share results achieved by applying their techniques on

  4. Civil Engineering Applications of Ground Penetrating Radar: Research Perspectives in COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Benedetto, Andrea; Loizos, Andreas; Slob, Evert; Tosti, Fabio

    2013-04-01

    can be used by GPR operators to identify the signatures generated by uncommon targets or by composite structures. Repeated evaluations of the electromagnetic field scattered by known targets can be performed by a forward solver, in order to estimate - through comparison with measured data - the physics and geometry of the region investigated by the GPR. It is possible to identify three main areas, in the GPR field, that have to be addressed in order to promote the use of this technology in the civil engineering. These are: a) increase of the system sensitivity to enable the usability in a wider range of conditions; b) research novel data processing algorithms/analysis tools for the interpretation of GPR results; c) contribute to the development of new standards and guidelines and to training of end users, that will also help to increase the awareness of operators. In this framework, the COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar", proposed by Lara Pajewski, "Roma Tre" University, Rome, Italy, has been approved in November 2012 and is going to start in April 2013. It is a 4-years ambitious project already involving 17 European Countries (AT, BE, CH, CZ, DE, EL, ES, FI, FR, HR, IT, NL, NO, PL, PT, TR, UK), as well as Australia and U.S.A. The project will be developed within the frame of a unique approach based on the integrated contribution of University researchers, software developers, geophysics experts, Non-Destructive Testing equipment designers and producers, end users from private companies and public agencies. The main objective of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of GPR techniques in civil engineering, whilst promoting the effective use of this safe and non-destructive technique in the monitoring of systems. In this interdisciplinary Action, advantages and limitations of GPR will be highlighted, leading to the identification of gaps in knowledge and technology

  5. Overview and comparative study of GPR international standards and guidelines - COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Marciniak, Marian; Benedetto, Andrea; Tosti, Fabio

    2016-04-01

    Ground Penetrating Radar (GPR) can be effectively used for non-destructive testing of composite structures and diagnostics affecting the whole life-cycle of civil engineering works. Nevertheless, few recognised international standards exist in this field and inhomogeneous recommendations are present in different countries. Moreover, the levels of knowledge, awareness and experience regarding the use of GPR in civil engineering vary strongly across different European areas. The COST Action TU1208 is working hard on leveraging these differences, by sharing and disseminating knowledge and experience, as well as by developing guidelines and protocols for a safe and effective use of GPR in civil engineering. GPR users need to know which is the best way to conduct GPR measurements and what the quality level for the results should be. The TU1208 guidelines will ensure a higher efficiency and quality of GPR services and they will constitute a scientific basis for the introduction of European Standards on the application of GPR in civil engineering. The aim of this contribution is to present an in-depth overview and critical analysis of the existing GPR international and national standards and guidelines. The main documents considered in our work are listed and briefly described in the following. Three standards are provided by the American Society for Testing and Materials (ASTM), to guide the GPR use for subsurface investigation, evaluation of asphalt-covered concrete bridge decks, and determination of pavement-layer thickness: 1. ASTM D6432-11, Standard Guide for Using the Surface Ground Penetrating Radar Method for Subsurface Investigation, ASTM International, West Conshohocken, PA, 2011, www.astm.org, DOI: 10.1520/D6432-11. 2. ASTM D6087-08, Standard Test Method for Evaluating Asphalt-Covered Concrete Bridge Decks Using Ground Penetrating Radar, ASTM International, West Conshohocken, PA, 2008, www.astm.org, DOI: 10.1520/D6087-08. 3. ASTM D4748-10, Standard Test Method

  6. Improving containment mass and energy releases for CONTEMPT-LT/028 TU with RELAP5/MOD3

    International Nuclear Information System (INIS)

    DaSilva, H.C.; Choe, W.G.

    1996-01-01

    In order to obtain boundary conditions for RELAP5/MOD3 best estimate (BE) large break (LB) loss-of-coolant accident (LOCA) calculations, it is necessary to utilize a separate containment analysis code CONTEMPT-LT/028 TU, which in turn accepts mass and energy releases from the RELAP5/MOD3 calculation. When these boundary conditions are obtained, they are observed to be significantly lower than those reported in FSAR containment analyses. This motivates the present study, where RELAP5/MOD3 mass and energy releases are generated using the same assumptions listed in the FSAR containment calculations. Then CONTEMPT-LT/028 TU pressures and temperatures calculated with both sets of mass and energy releases are compared. It is seen that those obtained with the RELAP5/MOD3 input are still significantly lower, indicating a level of conservatism in the FSAR mass and energy releases that is even above that explicitly listed and also incorporated into the RELAP5/MOD3 calculation. An important conclusion from this finding is that Environmental Qualification (EQ) issues requiring containment re-analyses are likely to be easily resolved if new mass and energy releases are calculated with state-of-the-art LOCA codes modeling the entire reactor coolant system, even when conservative assumptions are incorporated

  7. COST Action TU1208 - Working Group 4 - Combined use of GPR and other NDT methods & GPR applications in geosciences

    Science.gov (United States)

    Pajewski, Lara; Solla, Mercedes; Fontul, Simona

    2017-04-01

    This work aims at presenting the main results achieved by Working Group (WG) 4 "Different applications of GPR and other NDT technologies in civil engineering" of the COST (European COoperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" (www.GPRadar.eu, www.cost.eu). The main objective of the Action TU1208, started in April 2013 and ending in October 2017, is to exchange and increase scientific-technical knowledge and experience of Ground Penetrating Radar (GPR) techniques in civil engineering, whilst promoting in Europe the effective use of this safe non-destructive technique. The Action involves more than 150 Institutions from 28 COST Countries, a Cooperating State, 6 Near Neighbour Countries and 6 International Partner Countries. WG4 deals with the use of GPR outside from the civil engineering area, namely in archaeological prospecting and cultural heritage diagnostics, agriculture and management of water resources, investigation of polluted industrial sites, non-destructive testing of living tree trunks, planetary exploration, demining, localization of people buried under avalanches and debris, and more. Furthermore, this WG studies the integration of GPR with other Non-Destructive Testing (NDT) methods. The most relevant achievements stemming from WG4 will be presented during the 2017 EGU GA. These are: (i) The collection of thorough information on the state-of-the-art, ongoing studies, problems and future research needs on the topics of interest for this WG; (ii) The performance of a plethora of interesting case studies in important sites all over Europe, including well-known historical places such as Stonehenge (United Kingdom), Carnuntum (Austria), the Wawel Cathedral (Cracow, Poland), the Tholos Tomb of Acharnon (Athens, Greece), the Łazienki Royal Palace (Warsaw, Poland), and more; (iii) WG4 contributed to the TU1208 Education Pack, an open educational package conceived to teach GPR in University

  8. COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar": first-year activities and results

    Science.gov (United States)

    Pajewski, Lara; Benedetto, Andrea; Loizos, Andreas; Slob, Evert; Tosti, Fabio

    2014-05-01

    This work aims at presenting the first-year activities and results of COST (European COoperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar". This Action was launched in April 2013 and will last four years. The principal aim of COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of GPR techniques in civil engineering, whilst simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. Moreover, the Action is oriented to the following specific objectives and expected deliverables: (i) coordinating European scientists to highlight problems, merits and limits of current GPR systems; (ii) developing innovative protocols and guidelines, which will be published in a handbook and constitute a basis for European standards, for an effective GPR application in civil- engineering tasks; safety, economic and financial criteria will be integrated within the protocols; (iii) integrating competences for the improvement and merging of electromagnetic scattering techniques and of data- processing techniques; this will lead to a novel freeware tool for the localization of buried objects, shape-reconstruction and estimation of geophysical parameters useful for civil engineering needs; (iv) networking for the design, realization and optimization of innovative GPR equipment; (v) comparing GPR with different NDT techniques, such as ultrasonic, radiographic, liquid-penetrant, magnetic-particle, acoustic-emission and eddy-current testing; (vi) comparing GPR technology and methodology used in civil engineering with those used in other fields; (vii) promotion of a more widespread, advanced and efficient use of GPR in civil engineering; and (viii) organization of a high-level modular training program for GPR European users. Four Working Groups (WGs) carry out the research activities. The first WG

  9. Mutation of the conserved Gly94 and Gly126 in elongation factor Tu from Escherichia coli. Elucidation of their structural and functional roles

    DEFF Research Database (Denmark)

    Knudsen, Charlotte Rohde; Kjaersgård, I V; Wiborg, O

    1995-01-01

    All guanine-nucleotide-binding proteins cycle between an inactive, GDP-bound and an active, GTP-bound conformation whereby they function as molecular switches. Elongation factor Tu from Escherichia coli is used as a model for defining residues important in the switch mechanism. Gly94 and Gly126...

  10. Formulations of the endophytic bacterium Bacillus subtilis Tu-100 suppress Sclerotinia sclerotiorum on oilseed rape and improve plant vigor in field trials conducted at separate locations

    Science.gov (United States)

    Sclerotinia sclerotiorum causes serious yield losses in crops in The People’s Republic of China. Two formulations of oilseed rape seed containing the endophytic bacterium Bacillus subtilis Tu-100 were evaluated for suppression of this pathogen in field trials conducted at two independent locations....

  11. Keeleuuendus ja tõlkimine Noor-Eesti kultuurilise utoopia raames : Villem Ridala tõlgitud "Süütu" näitel / Daniele Monticelli

    Index Scriptorium Estoniae

    Monticelli, Daniele

    2006-01-01

    Keeleuuenduse ja tõlketegevuse mõningastest olulistest seostest Noor-Eesti liikumisega alanud kultuurilise revolutsiooni kontekstis. Lähema lingvistilise vaatluse alla võetakse Gabriele D'Annunzio "L'Innocente" ("Süütu") Villem Ridala tõlkes. Järgneb: Keel ja Kirjandus, 2006, nr. 6, lk. 477-490

  12. Nondestructive tests for railway monitoring. European Experience in COST Action TU1208

    Science.gov (United States)

    Fontul, Simona; Solla, Mercedes; Loizos, Andreas

    2016-04-01

    The railway monitoring is an important issue for a proper maintenance planning. With the increase in loads and travel speed, it is important to be able to diagnose the track defects and to plan the proper maintenance without interfering with the users. Traditionally, the maintenance actions are planned based on the geometric level parameters assessed without contact with the line, at traffic speed, by dedicated inspection vehicles. Nevertheless, the geometric condition of the line does not provide information on the defects causes. In order to complements the information on the causes, geophysics measurements can be performed in a nondestructive way. Among these later methods, Ground Penetrating Radar (GPR) is a quick and effective technique to evaluate infrastructure condition in a continuous manner, replacing or reducing the use of traditional drilling method. GPR application to railways infrastructures, during construction and monitoring phase, is relatively recent. It is based on the measuring of layers thicknesses and detection of structural changes. It also enables the assessment of materials properties that constitute the infrastructure and the evaluation of the different types of defects such as ballast pockets, fouled ballast, poor drainage, subgrade settlement and transitions problems. These deteriorations are generally the causes of vertical deviations in track geometry. Moreover, the development of new GPR systems with higher antenna frequencies, better data acquisition systems, more user friendly software and new algorithms for calculation of materials properties can lead to a regular use of GPR. A resume of the European experience in COST Action TU1208 of the application of GPR for railway monitoring and the measurement interpretation is presented in this paper. Also complementary nondestructive tests and other geophysical methods are referred, together with case studies of their application. The main troubleshooting and the needs for data analysis

  13. Moisture evaluation of wood material using GPR with WARR method - COST Action TU1208

    Science.gov (United States)

    Reci, Hamza; Sbart'i, Zoubir Mehdi; Pajewski, Lara; Marciniak, Marian

    2016-04-01

    This work deals with the study of the sensitivity of GPR electromagnetic waves to moisture variation in wood material in relation with the direction of fibers and polarization of Electromagnetic field. The relations between relative permittivity and moisture content and the amplitude attenuation with distance was a target study using the direct waves in Wide Angle Radar Reflection (WARR) configuration. Comparison of results measured with reflected waves and direct waves was of main importance since they have different behavior in relation with moisture variation, due to different path of propagation. This research activity has been carried out during one Short-Term Scientific Missions (STSM) funded by the COST (European Cooperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" in November-December 2015. In context of durability evaluation of construction materials, several studies have been carried out by the I2M team, University of Bordeaux, using direct and reflected waves for the evaluation of water content on concrete and wood materials [1-3]. As related to the wood material there is one study carried out using the reflected waves on wood for different humidity and different wood samples, in all the direction of polarization using GPR technique ground coupled antenna at 1.5 GHz [3]. This work continued with different moisture content in order to study the behavior of direct waves as function of moisture. Results taken from those measurements are compared with them from Fixed Offset (reflected method) with one antenna (1.5GHz or 2.6GHz), realized from the previous studies from the I2M and already published [1-3]. The results taken from this work from the reflected waves, show that the effect of wood anisotropy is significant on the variation of relative permittivity with moisture content on wood sample and that is in good agreement with the previous results [3-6]. As related to the direct waves, a small

  14. Assessment of waterfront location in hardened concrete by GPR within COST Action TU1208

    Science.gov (United States)

    Rodríguez-Abad, Isabel; Klysz, Gilles; Balayssac, Jean Paul; Pajewski, Lara

    2016-04-01

    This work focuses on the analysis of the capability of Ground-Penetrating radar (GPR) technique for evaluating how the water penetrates into concrete samples by means of the assessment of the waterfront advance. Research activities have been carried out during a Short-Term Scientific Missions (STSMs) funded by the COST (European Cooperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" in November 2015. The evaluation of water penetrability is crucial in most building materials, such us concrete, since, water and aggressive chemical agents dissolved therein contribute to the deterioration of the material. A number of techniques have been developed to measure their advance in concrete. Although the most common method for measuring water content is the gravimetric method by observing the change in mass, this method has a large number of disadvantages. In this context, non-destructive techniques as GPR play an interesting role. In particular, the application of GPR in the building materials area is providing very promising and interesting results regarding the building materials characterization and especially concrete deterioration evaluation [1-3]. In addition, recent experimental studies highlight the strong relation between wave propagation parameters (velocity and energy level) and water content advance [4-5]. Water content has a decisive influence on dielectric properties and those might be assessed by the study of the wave properties that are derived by using GPR. Therefore, the waterfront advance will result in a change on wave parameters. In line with this, this research is focused on the development of specific processing algorithms necessary to understand how the water penetrates and how the wave parameters will be affected regarding the location of the antenna in reference to the water absorption direction. For this purpose, concrete samples were manufactured, which after curing (90 days) and oven

  15. De l'importance stratégique des technologies intellectuelles et cognitives dans les sociétés technologiquement dominantes l'avenir des écritures dans la redéfinition des rapports de puissance et dans la transformation des espaces publics. Quelles économies politiques des savoirs ?

    OpenAIRE

    Juanals, Brigitte; Noyer, Jean-Max

    2007-01-01

    International audience; À l'ère numérique, les technologies intellectuelles et cognitives opèrent au cœur des modes de production et de circulation des savoirs et des apprentissages. En affectant les capacités associationnistes et analogiques des intelligences, elles posent également la question technopolitique des écritures et des mémoires numériques hypertextuelles en réseau. Elles opèrent à tous les niveaux d'échelle et participent de la performation des mondes politico-stratégiques et de ...

  16. A Whitham-Theory Sonic-Boom Analysis of the TU-144 Aircraft at a Mach Number of 2.2

    Science.gov (United States)

    Mack, Robert J.

    1999-01-01

    Officially, the Tu-144 was the first supersonic-cruise, passenger-carrying aircraft to enter commercial service. Design, construction, and testing were carried out by the Soviet Union, flight certification was by the Soviet Union, and the only regular passenger flights were scheduled and flown across the territory of the Soviet Union. Although it was not introduced to international passenger service, there were many significant engineering accomplishments achieved in the design, production, and flight of this aircraft. Development of the aircraft began with a prototype stage. Systematic testing and redesign led to a production aircraft in discrete stages that measurably improved the performance of the aircraft from the starting concept to final aircraft certification. It flew in competition with the English-French Concorde for a short time, but was withdrawn from national commercial service due to a lack of interest by airlines outside the Soviet Union. NASA became interested in the Tu- 144 aircraft when it was offered for use as a flying "testbed" in the study of operating characteristics of a supersonic-cruise commercial airplane. Since it had been in supersonic-cruise service, the Tu- 144 had operational characteris'tics similar to those anticipated in the conceptual aircraft designs being studied by the United States aircraft companies. In addition to the other operational tests being conducted on the Tu-144 aircraft, it was proposed that two sets of sonic-boom pressure signature measurements be made. The first set would be made on the ground, using techniques and devices similar to those in reference I and many other subsequent studies. A second set would be made in the air with an instrumented aircraft flying close under the Tu-144 in supersonic flight. Such in-flight measurements would require pressure gages that were capable of accurately recording the flow-field overpressures generated by the Tu- 144 at relatively close distances under the vehicle

  17. Is the sup(99m)Tc-Thyroid-uptake (TcTU) a valid measure of thyroidal trapping

    International Nuclear Information System (INIS)

    Mahlstedt, J.; Hotze, L.A.; Schwedes, H.G.; Joseph, K.

    1979-01-01

    In 2067 euthyroid goitrous patients living in an iodine deficient area which is under medical service of the university of Marburg/L. (W. Germany) sup(99m)Tc-Thyroid-Uptake as a measure for thyroidal trapping has been evaluated with respect to age and sex dependance. For both sexes there is marked decrease with increasing age, the values in the female sex are always higher than in the male sex. Comparison with the relevant results of ODDIE and coworkers reveals general correspondence, the differences of a more strong age and sex dependance are to expect in a region of iodine deficiency. Thus, the study confirms the validity of TcTU as a measure of thyroidal trapping. (orig.) [de

  18. [Information technologies intended to solve contingencies in the Peruvian subsidized health system affiliation: "Resuelve tu afiliación"].

    Science.gov (United States)

    Villegas-Ortega, José; Loyola-Martínez, César; Santisteban-Romero, Javier; Manchego-Lombardi, Mónica; Lozada-Urbano, Michelle

    2016-01-01

    The National Health Authority (SUSALUD) has developed an online platform, "ReSUelve tu afiliación", with the intent to solve the problems with health service access experienced by Peruvian citizens who hold health insurance policies through institutions that manage health insurance funds (IAFAS). This platform virtually articulates the main IAFAS in Peru, which receives requests from any user requiring an update on his/her affiliation status to be resolved within 24 hours. Nearly 8 months after the implementation of this platform, more than 55 thousand applications have been resolved, thus ensuring timely access to health services under the corresponding user coverage form. As a result, this platform has helped to guarantee citizens' rights to health service access in the face of infringement caused by delays in affiliation processing among the different IAFAS in Peru.

  19. COST Action TU1208 - Working Group 2 - GPR surveying of pavements, bridges, tunnels and buildings; underground utility and void sensing

    Science.gov (United States)

    Pajewski, Lara; Benedetto, Andrea; Derobert, Xavier; Fontul, Simona; Govedarica, Miro; Gregoire, Colette; Loizos, Andreas; Perez-Gracia, Vega; Plati, Christina; Ristic, Aleksandar; Tosti, Fabio; Van Geem, Carl

    2017-04-01

    This work aims at presenting the main results achieved by Working Group (WG) 2 "GPR surveying of pavements, bridges, tunnels and buildings; underground utility and void sensing" of the COST (European COoperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" (www.GPRadar.eu, www.cost.eu). The principal goal of the Action, started in April 2013 and ending in October 2017, is to exchange and increase scientific-technical knowledge and experience of Ground Penetrating Radar (GPR) techniques in civil engineering, whilst promoting throughout Europe the effective use of this safe non-destructive technique. The Action involves more than 300 Members from 28 COST Countries, a Cooperating State, 6 Near Neighbour Countries and 6 International Partner Countries. The most interesting achievements of WG2 include: 1. The state of the art on the use of GPR in civil engineering was composed and open issues were identified. The few existing international/national guidelines/protocols for GPR inspection in civil engineering were reviewed and discussed. Academic end-users, private companies and stakeholders presented their point of view and needs. 2. Guidelines for investigating flexible pavement by using GPR were prepared, with particular regard to layer-thickness assessment, moisture-content sensing, pavement-damage detection and classification, and other main GPR-based investigations in pavement engineering. 3. Guidelines for GPR sensing and mapping of underground utilities and voids were prepared, with a main focus on urban areas. 4. Guidelines for GPR assessment of concrete structures, with particular regard to inspections in bridges and tunnels, were prepared. 5. A report was composed, including a series of practical suggestions and very useful information to guide GPR users during building inspection. 6. WG2 Members carried out a plethora of case studies where GPR was used to survey roads, highways, airport runways, car

  20. Adıyaman’da Yayılış Gösteren Nepeta Cataria L. (Lamiaceae) Türü Üzerinde Morfolojik ve Sistematik Bir Çalışma

    OpenAIRE

    KILIÇ, Ömer

    2013-01-01

    Bu çalışmada Adıyaman ilinde yayılış gösteren N. cataria L. türünün morfolojik özellikleri sistematik açı-dan araştırıldı. Stereo mikroskop ile yapılan morfolojik çalışmalar sonucu türlerin yaprak şekli, yaprak tüy örtüsü,ginekeum, androkeum, korolla, kaliks, tohum ve lamentin tekalara birleşme özellikleri belirlendi ve Türkiye Flo-rası’nda ki özellikleriyle karşılaştırıldı. Ek olarak N. cataria türünün gövde ve yaprak tüy örtüsü, polen ve tohumözellikleri SE...

  1. Perception des perturbations climatiques, savoirs locaux et ...

    African Journals Online (AJOL)

    Les effets profonds du changement climatique sur l'agriculture, couplés avec la faible résilience et la grande vulnérabilité des populations aux chocs, pourraient réduire considérablement leur capacité de gestion des ressources naturelles et altérer ainsi leurs moyens d'existence, leur sécurité alimentaire et leur bien-être.

  2. tu ša šarri. La « loi du roi »dans la Babylonie achéménide et séleucide dātu ša šarri, The “Law of the King” in Achaemenid and Seleucid Babylonia

    Directory of Open Access Journals (Sweden)

    Sophie Démare-Lafont

    2009-06-01

    Full Text Available Cet article examine le champ sémantique de l’expression dātu ša šarri, « loi du roi », formée sur un terme d’origine vieux-perse (data. La dizaine d’occurrences d’époques achéménide et séleucide montre que la « loi du roi »désigne un mode d’élaboration de la norme issu de la pratique judiciaire du souverain, progressivement compilée pour former un corps de règles invoquées dans les contrats. Ce procédé de création de la loi et de fabrication des recueils législatifs rappelle celui du rescrit romain.This article investigates the meaning of the formula dātu ša šarri, “law of the king”, using the akkadian dātu based on the old Persian word dāta. The ten Achaemenid and Seleucid occurrences of this formula suggest a process of creation of legal rules comparable to the Roman rescript: the legal standard dātu ša šarri derives from the judicial practice of the king, whose decisions were progressively compiled in order to create a body of regulations which were invoked in contracts.

  3. Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRC

    Directory of Open Access Journals (Sweden)

    Richard F. Reschen

    2012-03-01

    Dgp71WD/Nedd1 proteins are essential for mitotic spindle formation. In human cells, Nedd1 targets γ-tubulin to both centrosomes and spindles, but in other organisms the function of Dgp71WD/Nedd1 is less clear. In Drosophila cells, Dgp71WD plays a major part in targeting γ-tubulin to spindles, but not centrosomes, while in Xenopus egg extracts, Nedd1 acts as a more general microtubule (MT organiser that can function independently of γ-tubulin. The interpretation of these studies, however, is complicated by the fact that some residual Dgp71WD/Nedd1 is likely present in the cells/extracts analysed. Here we generate a Dgp71WD null mutant lacking all but the last 12 nucleotides of coding sequence. The complete loss of Dgp71WD has no quantifiable effect on γ-tubulin or Centrosomin recruitment to the centrosome in larval brain cells. The recruitment of γ-tubulin to spindle MTs, however, is severely impaired, and spindle MT density is reduced in a manner that is indistinguishable from cells lacking Augmin or γ-TuRC function. In contrast, the absence of Dgp71WD leads to defects in the assembly of the acentrosomal female Meiosis I spindle that are more severe than those seen in Augmin or γ-TuRC mutants, indicating that Dgp71WD has additional functions that are independent of these complexes in oocytes. Moreover, the localisation of bicoid RNA during oogenesis, which requires γ-TuRC function, is unperturbed in Dgp71WD120 mutants. Thus, Dgp71WD is not simply a general cofactor required for γ-TuRC and/or Augmin targeting, and it appears to have a crucial role independent of these complexes in the acentrosomal Meiosis I spindle.

  4. GPR applications in civil engineering collaborating with a Company and preparation of material for the educational package to teach in Universities. STSM, COST Action TU1208

    Science.gov (United States)

    Sossa, Viviana; Assunção, Sonia; Pérez, Vega

    2017-04-01

    The STSM, Short-Term Missions, was carried out with the support of Murphy Survey company from Dublin - Ireland, was proposed for to Develop a module "GPR Applications in Archaeology" of the educational pack defined in the different meetings of the Cost Action TU 1208. The employ of GPR is mainly determined by the limits and uncertainties associated to this technique that affects to the measurements and the results. Private companies and end-users are highly interested in known the limits associated to particular cases and the advantages of the methodology compared to other studies. During this STSM, we plan to prepare a field survey, analyzing the possible problems and defining the objectives, and to acquire data to assess the structure. This data will be analyzed and processed in order to determine the limits of the technique in the particular case. The results will be compared to other surveys, in order to determine some clear restrictions that the company need to take into account in further works. Aknowledgments: This work has been partially funded by the EU COST Action TU1208, "Civil Engineering Applications of Ground Penetrating Radar", and it is a contribution to the working group 2.2 tasks in the COST Action TU1208.

  5. SCAT/ASCAT Soil Moisture Data: Enhancements in the TU Wien Method for Soil Moisture Retrieval From ERS and METOP Scatterometer Observations

    Science.gov (United States)

    Naeimi, V.; Wagner, W.; Bartalis, Z.

    2009-05-01

    Active microwave remote sensing observations of the scatterometers onboard the European Remote Sensing (ERS) and METeorological OPerational (METOP) satellites have been proven to be valuable for monitoring surface soil moisture globally using the so-called TU Wien change detection method. The METOP satellite series carrying ASCAT (Advanced Scatteromer) instrument for the next 15 years will ensure the continuity of soil moisture retrieval from scatterometers' data for more than 30 years considering the available ERS-1&2 Scatterometer (SCAT) observations dataset. With the aim of implementing a near real-time system for operational soil moisture remote sensing at EUMETSAT, the Institute of Photogrammetry and Remote Sensing at Vienna University of Technology (TU Wien) has developed an improved soil moisture retrieval algorithm to cope with some of the limitations found in the earlier method. The new algorithm has been implemented on a discrete global grid with 12.5 km quasi-equal grid spacing and includes a correction method to reduce azimuthal anisotropy of backscatter signal, new techniques for calculation of the model parameters and incorporates a comprehensive error modeling. The error analysis provides not only the quality information about the product but also facilitates accurate determination of historically driest/wettest conditions during the retrieval process. Enhancements made in the TU Wien retrieval algorithm result in a more uniform performance of the model and, consequently, a spatially consistent soil moisture product with a better spatial resolution.

  6. Rhymes, games and songs for the family and 4-5 ages children of «Educa a tu hijo» program participation

    Directory of Open Access Journals (Sweden)

    Nancy Darías Ávila

    2016-08-01

    Full Text Available The present work is directed to the community as an essential space of our society, it has the objective to encourage the participation of the family and 4-5 ages children in «Educa a tu hijo» program through a group of rhyme, games and songs activities. The research was developed at «Cuba Libre» popular council motivated for the existence of insufficiencies on the participation of «Educa a tu hijo» program and a poor attendance to the rest of planned activities. There were used a group of theoretical, empirical and mathematic methods to solve the problem and fulfil the objective. Taking into account the obtained information it was designed a high motivated propose, which contains rhyme, games and songs that on the Educa a tu hijo program promoters hands constitutes a way to increase family and children participation. The designed and applied propose has had a great acceptation on the studied population and a positive impact in the participation increasing.

  7. COST Action TU1208 - Working Group 3 - Electromagnetic modelling, inversion, imaging and data-processing techniques for Ground Penetrating Radar

    Science.gov (United States)

    Pajewski, Lara; Giannopoulos, Antonios; Sesnic, Silvestar; Randazzo, Andrea; Lambot, Sébastien; Benedetto, Francesco; Economou, Nikos

    2017-04-01

    This work aims at presenting the main results achieved by Working Group (WG) 3 "Electromagnetic methods for near-field scattering problems by buried structures; data processing techniques" of the COST (European COoperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" (www.GPRadar.eu, www.cost.eu). The main objective of the Action, started in April 2013 and ending in October 2017, is to exchange and increase scientific-technical knowledge and experience of Ground Penetrating Radar (GPR) techniques in civil engineering, whilst promoting in Europe the effective use of this safe non-destructive technique. The Action involves more than 150 Institutions from 28 COST Countries, a Cooperating State, 6 Near Neighbour Countries and 6 International Partner Countries. Among the most interesting achievements of WG3, we wish to mention the following ones: (i) A new open-source version of the finite-difference time-domain simulator gprMax was developed and released. The new gprMax is written in Python and includes many advanced features such as anisotropic and dispersive-material modelling, building of realistic heterogeneous objects with rough surfaces, built-in libraries of antenna models, optimisation of parameters based on Taguchi's method - and more. (ii) A new freeware CAD was developed and released, for the construction of two-dimensional gprMax models. This tool also includes scripts easing the execution of gprMax on multi-core machines or network of computers and scripts for a basic plotting of gprMax results. (iii) A series of interesting freeware codes were developed will be released by the end of the Action, implementing differential and integral forward-scattering methods, for the solution of simple electromagnetic problems by buried objects. (iv) An open database of synthetic and experimental GPR radargrams was created, in cooperation with WG2. The idea behind this initiative is to give researchers the

  8. Computer Applications in Counselor Education: Developing Cultural Competencies Through Online Collaboration of Future School Counselors / L’informatique dans l’éducation des orienteurs : le développement du savoir-faire culturel par la collaboration en

    Directory of Open Access Journals (Sweden)

    Vessela Ilieva

    2012-07-01

    Full Text Available This study examined the applications of computer-mediated student collaboration in a graduate multicultural counseling course. The course work included a reflective cultural competency building assignment that utilized online communication and collaboration using a wiki to extend and improve students’ multicultural counseling and social justice advocacy skills. The online assignment design was aligned with the current call for utilizing technology in the counseling profession. It further considered the needs of the future counselors, the current levels of exposure to and experience with available technology of the class members, and the opportunities for utilization of a variety of online-based tools to extend in-class and out-of-class discussions. Students’ response to this new form of class work and communication confirmed the potential of the online component to other aspects of counselor preparation, and the data analysis showed that the computer-mediated assignment was a valuable addition to developing students’ skills as multiculturally competent professionals. Cette étude a examiné les applications de la collaboration entre étudiants par l’entremise de l’informatique dans le cadre d’un cours d’études supérieures sur l’orientation en contexte multiculturel. Les travaux du cours comprenaient un travail de réflexion pour renforcer le savoir-faire culturel grâce à la communication et à la collaboration en ligne, en utilisant un wiki pour accroître et améliorer les aptitudes des étudiants en orientation en contexte multiculturel et en défense de la justice sociale. La conception du travail en ligne s’alignait sur la tendance actuelle pour une utilisation accrue de la technologie dans le métier de conseiller en orientation. On y tenait également compte des besoins des futurs conseillers, de leur degré d’exposition à la technologie et de leur expérience avec celle-ci, ainsi que des occasions pour l

  9. COST Action TU1208 - Working Group 1 - Design and realisation of Ground Penetrating Radar equipment for civil engineering applications

    Science.gov (United States)

    Pajewski, Lara; Benedetto, Andrea; D'Amico, Sebastiano; Ferrara, Vincenzo; Frezza, Fabrizio; Persico, Raffaele; Tosti, Fabio

    2017-04-01

    This work aims at presenting the main results achieved by Working Group (WG) 1 "Novel Ground Penetrating Radar instrumentation" of the COST (European COoperation in Science and Technology) Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" (www.cost.eu, www.GPRadar.eu). The principal goal of the Action, which started in April 2013 and is ending in October 2017, is to exchange and increase scientific-technical knowledge and experience of Ground Penetrating Radar techniques in civil engineering, whilst promoting throughout Europe the effective use of this safe non-destructive technique. The Action involves more than 300 Members from 28 COST Countries, a Cooperating State, 6 Near Neighbour Countries and 6 International Partner Countries. The most interesting achievements of WG1 include: 1. The state of the art on GPR systems and antennas was composed; merits and limits of current GPR systems in civil engineering applications were highlighted and open issues were identified. 2. The Action investigated the new challenge of inferring mechanical (strength and deformation) properties of flexible pavement from electromagnetic data. A semi-empirical method was developed by an Italian research team and tested over an Italian test site: a good agreement was found between the values measured by using a light falling weight deflectometer (LFWD) and the values estimated by using the proposed semi-empirical method, thereby showing great promises for large-scale mechanical inspections of pavements using GPR. Subsequently, the method was tested on a real scale, on an Italian road in the countryside: again, a good agreement between LFWD and GPR data was achieved. As a third step, the method was tested at larger scale, over three different road sections within the districts of Madrid and Guadalajara, in Spain: GPR surveys were carried out at the speed of traffic for a total of 39 kilometers, approximately; results were collected by using different GPR antennas

  10. Bioavailability of iron multi-amino acid chelate preparation in mice and human duodenal HuTu 80 cells.

    Science.gov (United States)

    Kajarabille, Naroa; Brown, Catriona; Cucliciu, Anamaria; Thapaliya, Gita; Latunde-Dada, Gladys O

    2017-03-01

    Strategies for preventing Fe deficiency include Fe supplementation and Fe fortification of foods. The absorption, metabolism and chemical characteristics of Fe multi-amino acid chelate (IMAAC) are not known. Absorption of IMAAC was compared with FeSO4 in Fe-depleted mice and in vitro chemical studies of the Fe supplement was performed in HuTu 80 cells. Hb repletion study was carried out in Fe-deficient CD1 mice that were fed for 10 d a diet supplemented with ferrous IMAAC or FeSO4. A control group of Fe-replete mice was fed a diet with adequate Fe concentrations throughout the study. Tissues were collected from the mice, and the expression of Fe-related genes was determined by quantitative PCR. Ferric reductase and Fe uptake were evaluated in HuTu 80 cells. Supplementation of the diet with FeSO4 or IMAAC significantly increased Hb levels (P<0·001) in Fe-deficient mice from initial 93·9 (SD 10·8) or 116·2 (SD 9·1) to 191 (SD 0·7) or 200 (SD 0·5) g/l, respectively. Initial and final Hb for the Fe-deficient control group were 87·4 (SD 6·7) and 111 (SD 11·7) g/l, respectively. Furthermore, the liver non-haem Fe of both supplement groups increased significantly (P<0·001). IMAAC was more effective at restoring Fe in the spleen compared with FeSO4 (P<0·005). Gene expression showed the IMAAC supplement absorption is regulated by the body's Fe status as it significantly up-regulated hepcidin (P<0·001) and down-regulated duodenal cytochrome b mRNA (P<0·005), similar to the effects seen with FeSO4. A significant proportion of Fe in IMAAC is reduced by ascorbic acid. Fe absorption in mice and cells was similar for both IMAAC and FeSO4 and both compounds induce and regulate Fe metabolism genes similarly in the maintenance of homeostasis in mice.

  11. I Passiuna tu Christù - Rito e teatro di una cantica popolare della Grecìa Salentina

    Directory of Open Access Journals (Sweden)

    Diana Costa

    2012-01-01

    Full Text Available Abstract – IT Questo articolo si basa sugli esiti di una ricerca di campo condotta nei paesi della Grecìa Salentina,una zona del basso Salento, dove si riscontra una peculiare modalità di esecuzione della cantica popolare grìca conosciuta come I Passiuna tu Christù (La Passione di Cristo. Attorno alla metà degli anni ´90 del ´900 la tradizione della cantica è stata oggetto di un prezioso recupero, fondato sulla memoria e disponibilità di alcuni anziani cantori, che l’ha riportata in vita dopo anni di silenzio. Lo studio si è quindi focalizzato sull'esecuzione di Zollino, uno dei comuni grecanico-salentini, dove opera l'associazione culturale "Bottega del Teatro" che per prima ha promosso il recupero di cui si è detto. Protagonista e interprete raffinato della versione zollinese è l'anziano cantore Antimo Pellegrino, la cui voce si fa teatro attraverso un uso sapiente del corpo fatto di gesti stilizzati, regolati da codici che consentono di comprendere il divenire performativo, ossia il testo in grìco, anche a chi non intende tale idioma. Abstract – EN This article is based on the results of a field research conducted in the countries of the Grecìa Salentina, an area of Salento, where there is a particular execution method of the folksong known as I Passiuna tu Christù (The Passion of the Christ. Around the mid-90s of the 20th century the tradition of this folksong has been the subject of a careful recovery, based on memory and availability of some older singers, who brought it back to life after years of silence. The study then focused on the Zollino’s execution, one of the grecanico-salentino’s common, in which works the cultural association "Bottega del Teatro", the first promoter of this recovery. The old singer Antimo Pellegrino is the player and interpreter of the Zollino’s refined version, whose voice becomes theater through a wise use of body made of stylized gestures, regulated by codes that allow you to

  12. 40Ar/39Ar Geochronology of Supergene K-bearing Sulfate Minerals: Cenozoic Continental Weathering, Landscape Evolution and Paleoclimates in the Tu-Ha Basin, Northwestern China

    Science.gov (United States)

    Yang, J.; Zheng, D.; Chen, W.; Hough, B.; Qiu, H.; Wang, W.; Wu, Y.; Yang, L.

    2017-12-01

    40Ar/39Ar incremental-heating analyses of supergene jarosite and yavapaiite from three weathering profiles at the Hongshan, Liuhuangshan, and Caihuagou deposits in the Tu-Ha Basin, China, were carried out to provide numerical constraints on the timing and duration of weathering and derive insights into local paleoclimatic and landscape evolution. Well-constrained plateau ages and best-fitting inverse isochrons have been obtained for 11 samples, yield 40Ar/39Ar ages ranging from 33.3±0.5 Ma to 3.3±0.4 Ma (1σ). Our 40Ar/39Ar ages, combined with the published ages, indicate that the high elevations sites hosting the most complete and complex weathering profiles present. The presence of ancient weathering ages in current outcrop in the Tu-Ha Basin suggests that denudation was not homogeneous, and the landscape evolution follow a scarp retreat model. These geochronological results suggest that a protracted history of weathering and supergene enrichment and, by inference, arid-semiarid climate (with at least a moderate amount of precipitation (>10 cm/y)) favorable to intense chemical weathering emerged at 33.3 Ma, 27.7-23.3 Ma, and 16.4-14.7 Ma, and prevailed from 11-7.8 Ma. Then, a progressive change from arid-semiarid towards hyperarid conditions and predominantly hyperarid conditions may have persisted since at least ca. 3.3 Ma. The climatic implications inferred from the weathering geochronology are in agreement with the chemical parameters and isotopic compositions of the Cenozoic sedimentary sequence from the Lianmuqin section in the Tu-Ha Basin, attesting to the reliability of weathering geochronology by the 40Ar/39Ar method as an indicator of paleoclimate in arid areas. Our results suggest that the retreat of the Paratethys Sea, which would have reduced eastward water vapor transport by the westerlies to the Tu-Ha Basin, led to its aridification in the Oligocene and that increased rain shadow effects, resulting from uplift of the Tibetan Plateau and Tian Shan

  13. Control de criaderos de Aedes aegypti con el programa Recicla por tu bienestar en Mérida, México

    Directory of Open Access Journals (Sweden)

    Mario Barrera Pérez

    2015-05-01

    Full Text Available Objetivos. Determinar la importancia de los criaderos de Ae. aegypti en Mérida; evaluar el impacto del programa Recicla or tu bienestar (RxB sobre la presencia/abundancia de éstos y la percepción de los habitantes. Material y métodos. Se calculó la importancia de los criaderos por su productividad pupal. Se realizaron muestreos pre y post RxB en colonias para cuantificar el total de recipientes/criaderos. Se aplicó una encuesta a participantes sobre la percepción sobre RxB en colonias seleccionadas. Resultados. Los botes, cubetas y diversos objetos chicos fueron los criaderos más importantes. RxB tuvo un impacto significativo en la reducción del número de recipientes (IRR=0.74, en los recipientes positivos (IRR=0.33 y en la positividad de las viviendas para Ae. aegypti (OR=0.41. Todos los entrevistados opinaron que RxB es necesario la gran mayoría piensa que es útil. Conclusiones. RxB debe ser considerada una buena práctica para el control del vector del dengue.

  14. Increasing HIV-related knowledge, communication, and testing intentions among Latinos: Protege tu Familia: Hazte la Prueba.

    Science.gov (United States)

    Rios-Ellis, Britt; Espinoza, Lilia; Bird, Mara; Garcia, Melawhy; D'Anna, Laura Hoyt; Bellamy, Laura; Scolari, Rosana

    2010-08-01

    Latinos are less likely to be aware of their HIV seropositivity than African Americans and Whites. 'Protege tu Familia: Hazte la Prueba' is a culturally and linguistically-sensitive HIV/AIDS prevention and testing program targeting Latino families. Using community-based participatory research techniques, Spanish-speaking bicultural community health workers helped develop and then used an educational flip chart and materials to conduct outreach and HIV prevention education in diverse settings. The intervention was created to increase HIV/AIDS-related knowledge, to improve communication regarding sexual risk, and to augment intentions to use condoms and test for HIV. A secondary purpose was to decrease HIV-related stigma by improving knowledge about transmission and reducing homophobia. Participants demonstrated significant increases in HIV knowledge, intention to practice safer sex and communicate sexual risk to partner(s), and intention to test for HIV. Improvements were also found in self-reported comfort levels when interacting with and caring for the HIV positive, thus decreasing HIV/AIDS-related stigma.

  15. Applications of GPR in archaeological prospecting and cultural heritage diagnostics: Research Perspectives in COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Benedetto, Andrea; Schettini, Giuseppe; Soldovieri, Francesco

    2013-04-01

    Ground Penetrating Radar (GPR) is a safe, non-destructive and non-invasive imaging technique that can be effectively used for advanced inspection of composite structures and for diagnostics affecting the whole life-cycle of civil engineering works. GPR can also be successfully employed in archaeological prospecting and cultural heritage diagnostics. In many Countries, where the archeological patrimony is an outstanding value (as Egypt, Israel, Greece, Central and South America), GPR is usually employed both as a diagnostic tool for the preventive detection of archeological structures and as the most advanced instrument able to prospect geometry and shape of underground valuable sites. However many uncertainties persist, because of several difficulties and ambiguities due to the complexity of the image processing in heterogeneous environment. It is possible to identify three main areas, in GPR field, that have to be addressed in order to promote the use of this technology in archaeological prospecting and cultural heritage diagnostics. These are: a) increase of the system sensitivity to enable the usability in a wider range of conditions, archeological sites are often located in impervious and critical environments; b) research novel data processing algorithms/analysis tools for the interpretation of GPR results; c) contribute to the development of new standards and guidelines and to training of end users, that will also help to increase the awareness of operators. It is also important to further investigate and promote a combined use of GPR with other non-invasive advanced techniques, typically used in the archeological investigation. In this framework, the COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar", proposed by a research team of "Roma Tre" University, Rome, Italy, has been approved in November 2012 and is going to start in April 2013. It is a 4-years ambitious project already involving 17 European Countries (AT, BE, CH, CZ, DE

  16. The nuclear inclusion a (NIa protease of turnip mosaic virus (TuMV cleaves amyloid-β.

    Directory of Open Access Journals (Sweden)

    Hye-Eun Han

    Full Text Available BACKGROUND: The nuclear inclusion a (NIa protease of turnip mosaic virus (TuMV is responsible for the processing of the viral polyprotein into functional proteins. NIa was previously shown to possess a relatively strict substrate specificity with a preference for Val-Xaa-His-Gln↓, with the scissile bond located after Gln. The presence of the same consensus sequence, Val(12-His-His-Gln(15, near the presumptive α-secretase cleavage site of the amyloid-β (Aβ peptide led us to hypothesize that NIa could possess activity against Aβ. METHODOLOGY/PRINCIPAL FINDINGS: Western blotting results showed that oligomeric as well as monomeric forms of Aβ can be degraded by NIa in vitro. The specific cleavage of Aβ was further confirmed by mass spectrometry analysis. NIa was shown to exist predominantly in the cytoplasm as observed by immunofluorescence microscopy. The overexpression of NIa in B103 neuroblastoma cells resulted in a significant reduction in cell death caused by both intracellularly generated and exogenously added Aβ. Moreover, lentiviral-mediated expression of NIa in APP(sw/PS1 transgenic mice significantly reduced the levels of Aβ and plaques in the brain. CONCLUSIONS/SIGNIFICANCE: These results indicate that the degradation of Aβ in the cytoplasm could be a novel strategy to control the levels of Aβ, plaque formation, and the associated cell death.

  17. « Corps noirs et médecins blancs. Entre race, sexe et genre : savoirs et représentations du corps des Africain(e)s dans les sciences médicales françaises (1780-1950) », Thèse, sous la direction d’Anne Carol, Aix-Marseille Uni

    OpenAIRE

    Peiretti-Courtis, Delphine

    2015-01-01

    A la croisée de l’histoire du corps, de la race, du genre, de la médecine et de l’histoire coloniale, cette thèse analyse la construction des savoirs et des représentations du corps des hommes et des femmes noirs d’Afrique subsaharienne dans la littérature médicale française des années 1780 aux années 1950. Le corps des Africain-e-s suscite un intérêt nouveau dans la littérature médicale européenne à la fin du XVIIIe siècle. Dans un contexte de taxinomie raciale et d'expansion coloniale, l'al...

  18. Appccounting: gestiona tu microempresa desde tu Smartphone

    OpenAIRE

    MARTÍNEZ GONZÁLEZ, FABIÁN

    2016-01-01

    [ES] El presente Trabajo de Fin de Grado consiste en la creación de una aplicación para sistemas operativos Android. El trabajo se plantea como el desarrollo de la aplicación en sí y como un proyecto de negocio. Dada la situación actual económica de España y el elevado número de micro-empresas existentes, hay una buena oportunidad de negocio a largo plazo proporcionando un pequeño sistema de información que una micro-empresa se pueda permitir y le permita crecer con el uso de l...

  19. Effects of carbonated mineral water treatment in Băile Tuşnad on chronic arterial occlusive disease – a case report

    Directory of Open Access Journals (Sweden)

    Gabriela Dogaru

    2017-05-01

    Full Text Available Introduction. Băile Tușnad spa is recognized for its role in the prevention and rehabilitation treatment of cardiovascular diseases, including chronic arterial occlusive disease, due to the presence of natural therapeutic factors: carbonated mineral waters through their peripheral vasodilator effects, natural mofettes, stimulating bioclimate. Aim. The current study aimed to assess the clinical efficiency of natural therapeutic factors in Băile Tuşnad for the continuation of rehabilitation treatment in a patient with chronic arterial occlusive disease, in order to encourage walking, reduce cardiovascular risk and improve quality of life. Material and method. Patient N.M., aged 75, with multiple cardiovascular risk factors. In 2013, he was diagnosed with lower limb peripheral ischemia syndrome stage II B Fontaine, predominantly left claudication at about 100 m, for which balloon angioplasty was performed. He attended rehabilitation treatment for 3 years in Baile Tuşnad, consisting of carbonated mineral water baths for 15 minutes, aerotherapy for 30 minutes daily for the stimulation of walking, massotherapy, kinesiotherapy, performed daily for 16 days, and in 2016, at the Rehabilitation Hospital Cluj-Napoca. He was clinically evaluated before and at the end of treatment by the Visual Analogue Scale, the 10-m walking test, adverse reactions, Doppler ultrasound. Results. At the end of treatment, an increase in the walking distance and speed, a significant improvement in the quality of gait was found; claudication occurred after 250 m, pain in the lower limbs was improved. There were no side reactions. Conclusions. Rehabilitation treatment with natural therapeutic factors influenced the clinical and functional picture, determining a significant improvement in the quality of gait and quality of life.

  20. Investigation of functional aspects of the N-terminal region of elongation factor Tu from Escherichia coli using a protein engineering approach

    DEFF Research Database (Denmark)

    Laurberg, M; Mansilla, Francisco; Clark, Brian F. C.

    1998-01-01

    The function of the N-terminal region of elongation factor Tu is still unexplained. Until recently, it has not been visible in electron density maps from x-ray crystallography studies, but the presence of several well conserved basic residues suggest that this part of the molecule is of structural...... importance for the factor to function properly. In this study, two lysines at positions 4 and 9 were mutated separately to alanine or glutamate. The resulting four point mutants were expressed and purified using the pGEX system. The untagged products were characterized with regard to guanine...

  1. Optimal power flow based TU/CHP/PV/WPP coordination in view of wind speed, solar irradiance and load correlations

    International Nuclear Information System (INIS)

    Azizipanah-Abarghooee, Rasoul; Niknam, Taher; Malekpour, Mostafa; Bavafa, Farhad; Kaji, Mahdi

    2015-01-01

    Highlights: • Formulate probabilistic OPF with VPE, multi-fuel options, POZs, FOR of CHP units. • Propose a new powerful optimization method based on enhanced black hole algorithm. • Coordinate of TUs, WPPs, PVs and CHP units together in the proposed problem. • Evaluate the impacts of inputs’ uncertainties and their correlations on the POPF. • Use the 2m + 1 point estimated method. - Abstract: This paper addresses a novel probabilistic optimisation framework for handling power system uncertainties in the optimal power flow (OPF) problem that considers all the essential factors of great impact in the OPF problem. The object is to study and model the correlation and fluctuation of load demands, photovoltaic (PV) and wind power plants (WPPs) which have an important influence on transmission lines and bus voltages. Moreover, as an important tool of saving waste heat energy in the thermoelectric power plant, the power networks share of combined heat and power (CHP) has increased dramatically in the past decade. So, the probabilistic OPF (POPF) problem considering valve point effects, multi-fuel options and prohibited zones of thermal units (TUs) is firstly formulated. The PV, WPP and CHP units are also modeled. Then, a new method utilizing enhanced binary black hole (EBBH) algorithm and 2m + 1 point estimated method is proposed to solve this problem and to handle the random nature of solar irradiance, wind speed and load of consumers. The correlation between input random variables is considered using a correlation matrix. Finally, numerical results are presented and considered regarding the IEEE 118-busses, including PV, WPP, CHP and TU at several busses. The simulation and comparison results obtained demonstrate the broad advantages and feasibility of the suggested framework in the presence of dependent non-Gaussian distribution of random variables

  2. Ground-penetrating radar investigation of St. Leonard's Crypt under the Wawel Cathedral (Cracow, Poland) - COST Action TU1208

    Science.gov (United States)

    Benedetto, Andrea; Pajewski, Lara; Dimitriadis, Klisthenis; Avlonitou, Pepi; Konstantakis, Yannis; Musiela, Małgorzata; Mitka, Bartosz; Lambot, Sébastien; Żakowska, Lidia

    2016-04-01

    The Wawel ensemble, including the Royal Castle, the Wawel Cathedral and other monuments, is perched on top of the Wawel hill immediately south of the Cracow Old Town, and is by far the most important collection of buildings in Poland. St. Leonard's Crypt is located under the Wawel Cathedral of St Stanislaus BM and St Wenceslaus M. It was built in the years 1090-1117 and was the western crypt of the pre-existing Romanesque Wawel Cathedral, so-called Hermanowska. Pope John Paul II said his first Mass on the altar of St. Leonard's Crypt on November 2, 1946, one day after his priestly ordination. The interior of the crypt is divided by eight columns into three naves with vaulted ceiling and ended with one apse. The tomb of Bishop Maurus, who died in 1118, is in the middle of the crypt under the floor; an inscription "+ MAVRVS EPC MCXVIII +" indicates the burial place and was made in 1938 after the completion of archaeological works which resulted in the discovery of this tomb. Moreover, the crypt hosts the tombs of six Polish kings and heroes: Michał Korybut Wiśniowiecki (King of the Polish-Lithuanian Commonwealth), Jan III Sobieski (King of the Polish-Lithuanian Commonwealth and Commander at the Battle of Vienna), Maria Kazimiera (Queen of the Polish-Lithuanian Commonwealth and consort to Jan III Sobieski), Józef Poniatowski (Prince of Poland and Marshal of France), Tadeusz Kościuszko (Polish general, revolutionary and a Brigadier General in the American Revolutionary War) and Władysław Sikorski (Prime Minister of the Polish Government in Exile and Commander-in-Chief of the Polish Armed Forces). The adjacent six crypts and corridors host the tombs of the other Polish kings, from Sigismund the Old to Augustus II the Strong, their families and several Polish heroes. In May 2015, the COST (European COoperation in Science and Technology) Action TU1208 "Civil engineering applications of Ground Penetrating Radar" organised and offered a Training School (TS) on the

  3. Exchanging knowledge and working together in COST Action TU1208: Short-Term Scientific Missions on Ground Penetrating Radar

    Science.gov (United States)

    Santos Assuncao, Sonia; De Smedt, Philippe; Giannakis, Iraklis; Matera, Loredana; Pinel, Nicolas; Dimitriadis, Klisthenis; Giannopoulos, Antonios; Sala, Jacopo; Lambot, Sébastien; Trinks, Immo; Marciniak, Marian; Pajewski, Lara

    2015-04-01

    This work aims at presenting the scientific results stemming from six Short-Term Scientific Missions (STSMs) funded by the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' (Action Chair: Lara Pajewski, STSM Manager: Marian Marciniak). STSMs are important means to develop linkages and scientific collaborations between participating institutions involved in a COST Action. Scientists have the possibility to go to an institution abroad, in order to undertake joint research and share techniques/equipment/infrastructures that may not be available in their own institution. STSMs are particularly intended for Early Stage Researchers (ESRs), i.e., young scientists who obtained their PhD since no more than 8 years when they started to be involved in the Action. Duration of a standard STSM can be from 5 to 90 days and the research activities carried out during this short stay shall specifically contribute to the achievement of the scientific objectives of the supporting COST Action. The first STSM was carried out by Lara Pajewski, visiting Antonis Giannopoulos at The University of Edinburgh (United Kingdom). The research activities focused on the electromagnetic modelling of Ground Penetrating Radar (GPR) responses to complex targets. A set of test scenarios was defined, to be used by research groups participating to Working Group 3 of COST Action TU1208, to test and compare different electromagnetic forward- and inverse-scattering methods; these scenarios were modelled by using the well-known finite-difference time-domain simulator GprMax. New Matlab procedures for the processing and visualization of GprMax output data were developed. During the second STSM, Iraklis Giannakis visited Lara Pajewski at Roma Tre University (Italy). The study was concerned with the numerical modelling of horn antennas for GPR. An air-coupled horn antenna was implemented in GprMax and tested in a realistically

  4. ELEKTROMAGNĒTISKI IETEKMĒTU HIDRODINAMISKO PROCESU EKSPERIMENTĀLI PĒTĪJUMI ŠĶIDRU METĀLU NOSLĒGTOS TILPUMOS

    OpenAIRE

    Andris Bojarevičs

    2014-01-01

    ANOTĀCIJA Promocijas darbs veidots kā paplašināts kopsavilkums par 18 zinātnisku publikāciju kopu, kas veltīta šķidru metālu kustības dinamikai noslēgtos tilpumos apstākļos, kad to ietekmē ārēji uzlikts magnētiskais lauks, kā pastāvīgs, tā arī laikā mainīgs. Praktiski visi darbi ir autora plānotu un realizētu fizikālu eksperimentālu modeļu izpētes izklāsts, kas iekļaujas magnētiskās hidrodinamikas jomā. Darbā atspoguļoti eksperimentālie rezultāti par dažādu ārēji rosinātu faktoru veidotu ...

  5. Raúl Gonzalez Tuñón desencuadernado. Políticas de la literatura, entre el libro y las publicaciones periódicas

    Directory of Open Access Journals (Sweden)

    Geraldine Rogers

    2015-11-01

    Full Text Available RESUMEN: el artículo revisa algunos supuestos sobre la producción literaria de Raúl González Tuñón en las décadas de 1920 y 1930 a partir de dos desplazamientos. En primer lugar, explora las políticas de la literatura que permitirían pensar, de manera menos esquemática que con la habitual categoría de “literatura política” con que se suelen abordar sus textos de la década del treinta, las apuestas y limitaciones de una escritura que desde su inicio se propuso como transformadora. En segundo lugar, el artículo pone el foco en la primera circulación de los textos, muchas veces en diarios y revistas, contextos formativos de una literatura que en gran medida surgió en sus páginas. Desencuadernar a Tuñón implica atender a la materialidad de sus escritos y explorar más allá de la tradicional figura del autor de libros, para indagar políticas de la escritura que articularon campos y prácticas, y experimentaron no sólo con nuevas formas estéticas sino también con diversos modos de circulación pública de las letras.

  6. Electromagnetic modelling, inversion and data-processing techniques for GPR: ongoing activities in Working Group 3 of COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Giannopoulos, Antonis; van der Kruk, Jan

    2015-04-01

    This work aims at presenting the ongoing research activities carried out in Working Group 3 (WG3) 'EM methods for near-field scattering problems by buried structures; data processing techniques' of the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' (www.GPRadar.eu). The principal goal of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of GPR techniques in civil engineering, simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. WG3 is structured in four Projects. Project 3.1 deals with 'Electromagnetic modelling for GPR applications.' Project 3.2 is concerned with 'Inversion and imaging techniques for GPR applications.' The topic of Project 3.3 is the 'Development of intrinsic models for describing near-field antenna effects, including antenna-medium coupling, for improved radar data processing using full-wave inversion.' Project 3.4 focuses on 'Advanced GPR data-processing algorithms.' Electromagnetic modeling tools that are being developed and improved include the Finite-Difference Time-Domain (FDTD) technique and the spectral domain Cylindrical-Wave Approach (CWA). One of the well-known freeware and versatile FDTD simulators is GprMax that enables an improved realistic representation of the soil/material hosting the sought structures and of the GPR antennas. Here, input/output tools are being developed to ease the definition of scenarios and the visualisation of numerical results. The CWA expresses the field scattered by subsurface two-dimensional targets with arbitrary cross-section as a sum of cylindrical waves. In this way, the interaction is taken into account of multiple scattered fields within the medium hosting the sought targets. Recently, the method has been extended to deal with through-the-wall scenarios. One of the

  7. Solid Phase Extraction of Bryophyte Lipids / Briofītu lipīdu cietfāzes ekstrakcijas frakcionēšana

    Directory of Open Access Journals (Sweden)

    Klavina Laura

    2015-11-01

    Full Text Available Pētījuma ietvaros izstrādāta vienkārša, ātra un viegli atkārtojama analītiska metode briofītu lipīdu frakcionēšanai. Lipīdu frakcijas frakcionēšanai izmantoja cietfāzes ekstrakciju ar silikagēlu un ar NH2 grupām modificētu silikagēlu, iegūtās vielu grupas kvantificēja kā to trimetilsilil atvasinājumus, izmantojot gāzes hromatogrāfiju-masas spektrometriju. Frakcionēšanu veica, izmantojot eluentu polaritātes gradienta principu (eluenti: heksāns, heksāns/hloroforms 5:1, hloroforms, kā pēdējo eluentu ar NH2 grupām modificēta silikagēla gadījumā izmantojot skābes (etiķskābes šķīdumu. Izpētes objekti bija divi Latvijā plaši izplatīti sūnaugi (Polytrichum commune, Dicranum polysetum, kuru sastāvā identificēja vairāk nekā 45 dažādus savienojumus, daudzi no kuriem ir ar augstu bioloģisko aktivitāti. Sūnaugu sastāvā identificēja sterolus, tokoferolus, taukskābes un citi savienojumus. Izmantotā frakcionēšanas shēma pavēra iespējas identificēt daudzus savienojumus, kuri kopējā ekstrakta hromatogrammā nebija uzrādīti, piemēram, alkānu rindas savienojumi, vairāki steroli. Līdz ar to sūnaugu lipīdu cietfāzes frakcionēšanas metode ļāva noteikt vielu klātbūtni, kuras atrodas mikrodaudzumos, bet kuras varēja ļaut izsekot brīofītu pārvērtībām bioģeoķīmiskos procesos. Ieteiktā frakcionēšanas metode ļāva arī identificēt vairākas vielu grupas, kuras varētu būt perspektīvas kā jaunas bioloģiski aktīvas vielas, kā arī palīdzēja labāk izprast briofītu metabolismu, piemēram starpsugu atšķirības un sastāva sezonālās mainības raksturu.

  8. Za přečtení stojí... Kateřina Tučková: Vyhnání Gerty Schnirch. Brno, Host 2009

    Czech Academy of Sciences Publication Activity Database

    Košnarová, Veronika

    2010-01-01

    Roč. 60, č. 5 (2010), s. 237-240 ISSN 0009-0786 Institutional research plan: CEZ:AV0Z90560517 Keywords : Czech literature * Tučková, Kateřina * interpretations Subject RIV: AJ - Letters, Mass-media, Audiovision

  9. Professional knowledge and MSD prevention: portrait of their transmission during training and the intervention perspective Savoirs professionnels et prévention des TMS : portrait de leur transmission durant la formation et perspectives d’intervention Saberes profesionales y prevención de las LMS : un retrato de su transmisión durante la formación y perspectivas de intervención

    Directory of Open Access Journals (Sweden)

    Sylvie Ouellet

    2009-11-01

    Full Text Available When training is being organized in enterprises where the work is considered as being repetitive and manual, the trainer is usually chosen from among experienced workers with recognized expertise. The study’s aim was to analyze the types of knowledge transmitted by worker-trainers to apprentices in a food-processing industry in order to prevent musculoskeletal disorders. The knowledge orally transmitted by the trainers was analyzed from audio recordings of the daily follow-up of the training given. The ergonomic approach developed in this study has shown that knowledge linked to health protection, and to the “why” of movements and the benchmarks, aren’t as easily transmitted as others. The complexity of the transmission phenomenon and the need to help worker-trainers in developing the competency for passing on this knowledge were demonstrated. Intervention scenarios are proposed.Lors de l’organisation de formations dans les entreprises où le travail est considéré manuel et répétitif, le formateur est habituellement choisi parmi les travailleurs expérimentés dont le savoir-faire est reconnu. L’étude a eu pour objectif de faire l’analyse des types de savoirs transmis par des travailleurs-formateurs à des apprentis dans une entreprise du secteur agroalimentaire avec l’objectif de prévenir les troubles musculo-squelettiques. Une analyse des savoirs transmis verbalement par les formateurs a été effectuée à partir d’enregistrements audio provenant du suivi quotidien des formations données. La démarche ergonomique développée dans cette étude a permis de montrer que les savoirs liés à la protection de la santé, au « pourquoi » des gestes et aux repères sont plus difficilement transmis que d’autres. La complexité du phénomène de transmission et la nécessité d’accompagner les travailleurs-formateurs dans le développement de compétences pour transmettre ces savoirs ont été mises en évidence. Des

  10. Savoirs professionnels et prévention des TMS : portrait de leur transmission durant la formation et perspectives d’intervention Professional knowledge and MSD prevention: portrait of their transmission during training and the intervention perspective Saberes profesionales y prevención de las LMS : un retrato de su transmisión durante la formación y perspectivas de intervención

    Directory of Open Access Journals (Sweden)

    Sylvie Ouellet

    2009-11-01

    Full Text Available Lors de l’organisation de formations dans les entreprises où le travail est considéré manuel et répétitif, le formateur est habituellement choisi parmi les travailleurs expérimentés dont le savoir-faire est reconnu. L’étude a eu pour objectif de faire l’analyse des types de savoirs transmis par des travailleurs-formateurs à des apprentis dans une entreprise du secteur agroalimentaire avec l’objectif de prévenir les troubles musculo-squelettiques. Une analyse des savoirs transmis verbalement par les formateurs a été effectuée à partir d’enregistrements audio provenant du suivi quotidien des formations données. La démarche ergonomique développée dans cette étude a permis de montrer que les savoirs liés à la protection de la santé, au « pourquoi » des gestes et aux repères sont plus difficilement transmis que d’autres. La complexité du phénomène de transmission et la nécessité d’accompagner les travailleurs-formateurs dans le développement de compétences pour transmettre ces savoirs ont été mises en évidence. Des perspectives d’intervention sont proposées.When training is being organized in enterprises where the work is considered as being repetitive and manual, the trainer is usually chosen from among experienced workers with recognized expertise. The study’s aim was to analyze the types of knowledge transmitted by worker-trainers to apprentices in a food-processing industry in order to prevent musculoskeletal disorders. The knowledge orally transmitted by the trainers was analyzed from audio recordings of the daily follow-up of the training given. The ergonomic approach developed in this study has shown that knowledge linked to health protection, and to the « why » of movements and the benchmarks, aren’t as easily transmitted as others. The complexity of the transmission phenomenon and the need to help worker-trainers in developing the competency for passing on this knowledge were

  11. Blockage of both the extrinsic and intrinsic pathways of diazinon-induced apoptosis in PaTu cells by magnesium oxide and selenium nanoparticles

    Directory of Open Access Journals (Sweden)

    Shiri M

    2016-11-01

    Full Text Available Mahdi Shiri,1,2,* Mona Navaei-Nigjeh,1,3,* Maryam Baeeri,1 Mahban Rahimifard,1 Hossein Mahboudi,4 Ahmad Reza Shahverdi,5 Abbas Kebriaeezadeh,1 Mohammad Abdollahi1,6,7 1Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 2School of Medicine, Artesh University of Medical Sciences, 3Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 4Department of Biotechnology, Faculty of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 5Department of Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, 6Toxicology Interest Group, USERN, 7Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran *These authors contributed equally to this work Abstract: Diazinon (DZ is an organophosphorus insecticide that acts as an acetylcholinesterase inhibitor. It is important to note that it can induce oxidative stress, lipid peroxidation, diabetic disorders, and cytotoxicity. Magnesium oxide (MgO and selenium nanoparticles (Se NPs showed promising protection against oxidative stress, lipid peroxidation, cytotoxicity, and diabetic disorders. Therefore, this study was conducted to explore the possible protective mechanisms of MgO and Se NPs against DZ-induced cytotoxicity in PaTu cell line. Cytotoxicity of DZ, in the presence or absence of effective doses of MgO and Se NPs, was determined in human pancreatic cancer cell line (PaTu cells after 24 hours of exposure by using mitochondrial activity and mitochondrial membrane potential assays. Then, the insulin, proinsulin, and C-peptide release; caspase-3 and -9 activities; and total thiol molecule levels were assessed. Determination of cell viability, including apoptotic and necrotic cells, was assessed via acridine orange/ethidium bromide double

  12. COST Action TU1206 "SUB-URBAN - A European network to improve understanding and use of the ground beneath our cities"

    Science.gov (United States)

    Campbell, Diarmad; de Beer, Johannes; Lawrence, David; van der Meulen, Michiel; Mielby, Susie; Hay, David; Scanlon, Ray; Campenhout, Ignace; Taugs, Renate; Eriksson, Ingelov

    2014-05-01

    Sustainable urbanisation is the focus of SUB-URBAN, a European Cooperation in Science and Technology (COST) Action TU1206 - A European network to improve understanding and use of the ground beneath our cities. This aims to transform relationships between experts who develop urban subsurface geoscience knowledge - principally national Geological Survey Organisations (GSOs), and those who can most benefit from it - urban decision makers, planners, practitioners and the wider research community. Under COST's Transport and Urban Development Domain, SUB-URBAN has established a network of GSOs and other researchers in over 20 countries, to draw together and evaluate collective urban geoscience research in 3D/4D characterisation, prediction and visualisation. Knowledge exchange between researchers and City-partners within 'SUB-URBAN' is already facilitating new city-scale subsurface projects, and is developing a tool-box of good-practice guidance, decision-support tools, and cost-effective methodologies that are appropriate to local needs and circumstances. These are intended to act as catalysts in the transformation of relationships between geoscientists and urban decision-makers more generally. As a result, the importance of the urban sub-surface in the sustainable development of our cities will be better appreciated, and the conflicting demands currently placed on it will be acknowledged, and resolved appropriately. Existing city-scale 3D/4D model exemplars are being developed by partners in the UK (Glasgow, London), Germany (Hamburg) and France (Paris). These draw on extensive ground investigation (10s-100s of thousands of boreholes) and other data. Model linkage enables prediction of groundwater, heat, SuDS, and engineering properties. Combined subsurface and above-ground (CityGML, BIMs) models are in preparation. These models will provide valuable tools for more holistic urban planning; identifying subsurface opportunities and saving costs by reducing uncertainty in

  13. Gigantes digitales. Quijote en 17000 tuits de Diego Buendía y Escribe tu propio Quijote de Belén Gache

    Directory of Open Access Journals (Sweden)

    Celia Corral Cañas

    2015-05-01

    Full Text Available To incorporate Don Quixote into the virtual environment offers many possibilities, from the literal adaptation into an electronic format, such as rewriting it on Twitter, to the allusion to the book in an avant-garde creation. Thus, among the various ways of tackling Don Quixote in Twitter, the project El Quijote en 17000 tuits by Diego Buendía, who makes a fragmented transcript in 17000 sections or tweets, stands out. Furthermore, Escribe tu propio Quijote by Belén Gache honors Cervantes’ novel with a simple interactive game that invites the reader to rethink the authorship issue within and outside the work. These two creations, born from the junction of the famous novel by Cervantes and the particularities of the new ecosystem, recover the quixotic nature to integrate it, from very different paths, into the digital universe.

  14. TuGen

    DEFF Research Database (Denmark)

    Gilling, Lasse

    An implementation of Mann's method of generating synthetic turbulence is described. A brief introduction to the method is given prior to some details on the implementation. Several tests to verify the implementation follows and finally the use of the program is described....

  15. Construye tu Música

    Directory of Open Access Journals (Sweden)

    Contreras, Antonio de

    2000-05-01

    Full Text Available En el Sistema Educativo actual la composición musical está contemplada en el tramo final de los estudios de Conservatorio, tras muchos años de adiestramiento técnico-instrumental y teórico. Por otra parte, si visitamos un Aula de Educación Plástica de un Instituto, podemos ver a los alumnos de Secundaria expresándose, canalizando su creatividad a través de colores, formas y volúmenes, sin prejuicios, con un mínimo y, en la mayoría de los casos, muy simple bagaje de conocimientos técnicos previos. Está claro que se trata de dos artes completamente diferentes, también es bien sabido y repetido hasta la saciedad el carácter abstracto de la música. Pero así y todo ¿Será posible arbitrar un modo de acercarse a la música desde dentro, desde la práctica de la composición musical de una forma directa y simple, sin necesidad de una formación musical de nivel superior, de forma parecida a como se plantea la actividad creativa en la educación plástica? ¿Será posible complementar dicha práctica con la subsiguiente interpretación de las composiciones y la crítica de las producciones ajenas del mismo nivel? Las preguntas no son, por supuesto, nuevas: ya los grandes pedagogos musicales del primer cuarto de siglo las plantearon y resolvieron cada uno a su modo. La siguiente comunicación pretende dar a conocer los resultados de una investigación en el Aula de música, realizada por el autor durante los cuatro últimos años, que parte de una propuesta original en este sentido.

  16. GPR surveying of transport infrastructures and buildings; underground utility and void sensing - ongoing activities in Working Group 2 of COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Plati, Christina; Derobert, Xavier

    2015-04-01

    This work aims at presenting the ongoing research activities carried out in Working Group 2 'GPR surveying of pavements, bridges, tunnels and buildings; underground utility and void sensing' of the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' (www.GPRadar.eu). The principal goal of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of Ground Penetrating Radar (GPR) techniques in civil engineering, whilst simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. Four Working Groups (WGs) carry out the research activities. WG1 focuses on the development of innovative GPR equipment dedicated for civil engineering applications. WG2 deals with the development of guidelines and protocols for the surveying, through the use of a GPR system, of transport infrastructure and buildings, as well as for the sensing of utilities and voids. WG3 deals with the development of electromagnetic forward and inverse scattering methods, for the characterization of GPR scenarios, as well as with data- processing algorithms for the elaboration of the data collected during GPR surveys. WG4 is concerned with the use of GPR in fields different from the civil engineering, as well as with the integration of GPR with other non-destructive testing techniques. Each WG includes several Projects. WG2 includes five Projects. Project 2.1 focuses on outlining 'Innovative inspection procedures for effective GPR surveying of critical transport infrastructures (pavements, bridges and tunnels).' Project 2.2 is concerned with the development of 'Innovative inspection procedures for effective GPR surveying of buildings.' Project 2.3 deals with identifying 'Innovative inspection procedures for effective GPR sensing and mapping of underground utilities and voids, with a focus to urban

  17. Divdaivu Ginka (Ginkgo Biloba) farmakoloģiskās īpašības un tā preparātu aprite SIA "Gulbju aptiekā"

    OpenAIRE

    Indriča, Alīna

    2014-01-01

    Divdaivu ginks (Ginkgo biloba) ir viens no vecākajiem kokiem pasaulē. Ķīnas tradicionālajā medicīnā ginka lapas un sēklas izmanto jau vismaz 5000 gadus. Standartizēts Ginkgo biloba ekstrakts satur – 24% flavonglikozīdu un 6% terpēnlaktonu. Šī darba mērķis ir veikt apkopoto datu analīzi par Ginkgo biloba preparātu apriti „Gulbju aptiekā” – Gulbenē, 2013. gada laikā, kā arī noskaidrot cilvēku informētību par Ginkgo biloba preparātu lietošanu. Darbā tika izvirzīti 4 uzdevumi: Noskaidrot, k...

  18. Depresijas, traumatiskās pieredzes un disociācijas saistība pacientiem ar diagnosticētu depresiju un psihiski veseliem cilvēkiem

    OpenAIRE

    Bērtule, Marika

    2014-01-01

    Pētījuma mērķis: noteikt kāda saistība pastāv starp depresijas izteiktības pakāpi, traumatisko pieredzi un disociatīvo traucējumu simptomu līmeni. Pētījuma dalībnieki: grupa ar diagnosticētu depresiju - 36 pacienti. Kontroles grupa – 58 personas. Instrumentārijs: Beka depresijas izpētes aptauja (BDI-II), Traumatisko pagātnes notikumu aptauja (TAQ), Disociācijas Multidimensiju Aptauja (MID-6). Rezultāts: grupā ar diagnosticētu depresiju depresijas izteiktības, psihotraumatiskās piered...

  19. Synergism between the GTPase activities of EF-Tu.GTP and EF-G.GTP on empty ribosomes. Elongation factors as stimulators of the ribosomal oscillation between two conformations.

    Science.gov (United States)

    Mesters, J R; Potapov, A P; de Graaf, J M; Kraal, B

    1994-10-07

    A remarkable positive cooperativity between the GTPase activities of EF-Tu and EF-G on empty ribosomes from Escherichia coli has been discovered. This cooperativity implies a decrease of the corresponding apparent KM values of the empty ribosome for either elongation factor: from more than 10 microM to 0.5 microM for EF-Tu.GTP by the addition of 0.25 microM EF-G and from 0.7 microM to 0.5 microM for EF-G.GTP by the addition of 3 microM EF-Tu. In a further analysis of this phenomenon, the effects of various specific antibiotics were studied: thiostrepton, fusidic acid, tetracycline, pulvomycin and kirromycin appeared to inhibit the synergistic effect, whereas streptomycin was found to stimulate it. Even in the present minimal system the ribosomes respond to the above-mentioned antibiotics in a way surprisingly similar to that in the coupled system with mRNA and tRNAs. The cooperativity seems not to be due to a simultaneous binding of the two elongation factors to the ribosome as revealed by studying the effects of fusidic acid and kirromycin, and by band-shift experiments by means of gel electrophoresis under non-denaturing conditions. Our experimental data and the kinetic analysis of alternative models provide evidence that EF-Tu.GTP and EF-G.GTP interact sequentially with empty ribosomes that oscillate between two different conformations, one for each elongation factor. Apparently, ribosomes have an intrinsic property for oscillation as normally observed during protein synthesis with a frequency paced by the events of tRNA binding and translocation.

  20. Design and testing of Ground Penetrating Radar equipment dedicated for civil engineering applications: ongoing activities in Working Group 1 of COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Manacorda, Guido; Persico, Raffaele

    2015-04-01

    This work aims at presenting the ongoing research activities carried out in Working Group 1 'Novel GPR instrumentation' of the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' (www.GPRadar.eu). The principal goal of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of GPR techniques in civil engineering, simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. Working Group 1 (WG1) of the Action focuses on the development of innovative GPR equipment dedicated for civil engineering applications. It includes three Projects. Project 1.1 is focused on the 'Design, realisation and optimisation of innovative GPR equipment for the monitoring of critical transport infrastructures and buildings, and for the sensing of underground utilities and voids.' Project 1.2 is concerned with the 'Development and definition of advanced testing, calibration and stability procedures and protocols, for GPR equipment.' Project 1.3 deals with the 'Design, modelling and optimisation of GPR antennas.' During the first year of the Action, WG1 Members coordinated between themselves to address the state of the art and open problems in the scientific fields identified by the above-mentioned Projects [1, 2]. In carrying our this work, the WG1 strongly benefited from the participation of IDS Ingegneria dei Sistemi, one of the biggest GPR manufacturers, as well as from the contribution of external experts as David J. Daniels and Erica Utsi, sharing with the Action Members their wide experience on GPR technology and methodology (First General Meeting, July 2013). The synergy with WG2 and WG4 of the Action was useful for a deep understanding of the problems, merits and limits of available GPR equipment, as well as to discuss how to quantify the reliability of GPR results. An

  1. Intégrer la notion d’équité : création d'un cadre d'action pour placer la mobilisation du savoir et l’équité en santé au coeur des rapports sur l’état de santé des populations

    Directory of Open Access Journals (Sweden)

    Lesley Ann Dyck

    2018-01-01

    Full Text Available Les centres de collaboration nationale en santé publique (CCNSP ont collaboré à l’élaboration d’un cadre d’action visant à intégrer la notion d’équité dans les rapports sur l’état de santé des populations (RESP. Ce cadre d’action rassemble les comptes rendus de recherche et une expérience de terrain fondée sur une approche originale d’apprentissage collaboratif faisant appel aux praticiens en santé publique du Canada. Dans cet article, nous présentons le cadre d’action, nous décrivons le processus d’apprentissage et nous situons les RESP au sein des travaux en cours dans le secteur de la santé publique. Nous analysons ensuite la nature des données probantes sur les déterminants sociaux de la santé à titre de dimension clé pour déterminer sur quoi portent les rapports et comment ces données y sont intégrées. Enfin, nous établissons le lien entre les données et la mise en oeuvre en explorant le concept de renseignements exploitables et en détaillant le cadre d’action visant à intégrer la notion d’équité dans les RESP. Nous concluons sur l’importance de placer la mobilisation du savoir au coeur du processus d’élaboration des RESP et nous apportons des suggestions pour les prochaines étapes. Notre objectif est d’encourager les praticiens à utiliser le cadre d’action, à en discuter et, ultimement, à le renforcer.

  2. Saistība starp pusaudžu piederības izjūtu skolai un mācību sasniegumiem

    OpenAIRE

    Jēkabsone, Agnese

    2008-01-01

    Jēkabsone, A., bakalaura darbs „ Saistība starp pusaudžu piederības izjūtu skolai un mācību sasniegumiem”. Pētījuma teorētiskajā daļā autore apkopo un analizē Ā. Adlera, M. Balsona, E. Eriksona, J. Maļickas atziņas par piederības jēdzienu, tās uzbūvi, kā arī teorētiski pamato piederības izjūtas un mācību sasniegumu noteicošām pazīmes. Pētījuma empīriskajā daļā tiek veikta piederības izjūtas un mācību sasniegumu pazīmju empīriskā pārbaude. Datu ieguvei tika izmantota anketēšana, savukār...

  3. Proceso de educación intercultural en primera infancia: programa educa a tu hijo -Cuba- y programa hogares comunitarios de bienestar -HBC -Colombia

    Directory of Open Access Journals (Sweden)

    Cindy Tatiana Capera Espinel

    2017-09-01

    Full Text Available En el presente artículo se pretende hacer un análisis comparativo, desde una perspectiva intercultural, de dos programas educativos no convencionales, el programa cubano Educa a tu hijo y el programa colombiano Ho­gares Comunitarios de Bienestar —HCB—, dirigidos a la educación de la primera infancia. Se hace referencia a las características y estrategias en las que se evidencia el vínculo existente entre educación intercultural y la primera infancia, con el fin de fortalecer el desarrollo integral de niños y niñas. Esto surge como resultado de una experiencia de internacionalización en la que se desarrolló el curso de corta duración titulado «Didáctica de la inclusión social y la actividad física» durante dieciséis días en Cuba, ello como parte del proceso de formación de pedagogos infantiles de UNIMINUTO.

  4. Tu Amigo Pepe: Evaluation of a Multi-media Marketing Campaign that Targets Young Latino Immigrant MSM with HIV Testing Messages.

    Science.gov (United States)

    Solorio, Rosa; Norton-Shelpuk, Pamela; Forehand, Mark; Montaño, Daniel; Stern, Joshua; Aguirre, Joel; Martinez, Marcos

    2016-09-01

    Latino immigrant men who have sex with men (MSM) are at risk for HIV and delayed diagnosis in the United States. This paper describes the evaluation of a pilot of the Tu Amigo Pepe, a multimedia HIV testing campaign aimed at Latino MSM in Seattle, WA particularly targeting immigrants who may not identify as gay, ages 18-30 years old. The 16-week campaign included Spanish-language radio public service announcements (PSAs), a Web site, social media outreach, a reminder system using mobile technology, print materials and a toll-free hotline. In developing the PSAs, the Integrated Behavioral Model was used as a framework to reframe negative attitudes, beliefs and norms towards HIV testing with positive ones as well as to promote self-efficacy towards HIV testing. The campaign had a significant and immediate impact on attitudes, beliefs, norms and self-efficacy towards HIV testing as well as on actual behavior, with HIV testing rates increasing over time.

  5. La satisfacción de residentes con su colonia y el programa gubernamental Tu Casa en el estado de Zacatecas

    Directory of Open Access Journals (Sweden)

    Jorge Ibarra Salazar

    2016-01-01

    Full Text Available El grado de satisfacción residencial, considerado como un indicador de nivel de vida, tiene como uno de sus componentes la satisfacción con la colonia de los individuos. En este artículo estimamos una serie de modelos para analizar el grado de satisfacción con la colonia de una muestra de hogares en el estado de Zacatecas. Las estimaciones nos permiten determinar si el programa federal de vivienda Tu Casa en ese estado, operado de 2004 a 2009, tuvo alguna influencia en el grado de satisfacción con la colonia, de acuerdo con la percepción de los residentes entrevistados. Encontramos evidencia de que el referido programa causó un efecto significativo en el grado de satisfacción del grupo de familias beneficiarias. Además de ese resultado, la estimación por mínimos cuadrados ordinarios muestra que el acceso vial, la contaminación ambiental, la percepción del valor de la casa y el tiempo de vivir en la vivienda influyen de forma significativa en el grado de satisfacción con la colonia. En los modelos estimados por probit y logit encontramos evidencia de que la seguridad pública y la posesión del inmueble también influyen en tal satisfacción.

  6. CERN Library | Sandrine Saison-Marsollier, Corinne Pralavorio and Michel Spiro present "Si tu devais me dessiner l’Univers…" | 10 December

    CERN Multimedia

    CERN Library

    2015-01-01

    Sandrine Saison-Marsollier, Corinne Pralavorio and Michel Spiro present Si tu devais me dessiner l’Univers… Thursday, 10 December 2015 at 3.30 p.m. at the Library, Building 52-1-052 Tea and coffee will be served at 3 p.m. In 2014, CERN launched an art competition for local primary schools. Children were asked to come up with questions about the universe, matter and working as a researcher. The initiative was so successful that it has been turned into a book that teachers can explore with their pupils, discussing the questions and discovering the answers together. The book is laid out in double-page spreads, with the child’s illustration on one page and the question and its answer opposite. The answers take the form of a short text written by Michel Spiro, the competition’s scientific advisor, together with a cultural quotation whose purpose is to highlight the close association between science, literature and philosophy. The questions include: What was there...

  7. Tu e o de quem?" Tecendo os os com Bakhtin, Vigotski e Paulo Freire / Who do you think you are?" Commenting the wires with Bakhtin, Vigotski and Freire

    Directory of Open Access Journals (Sweden)

    Joselito Manoel de Jesus

    2010-08-01

    Full Text Available RESUMO: Este artigo analisa o enunciado "Tu é o de quem?", apontando para a responsabilidade que um filho da roça tem como partícipe do sustento da família e como essa realidade imediata constitui fios que enredam sua existência. Adota as contribuições de Bakhtin, Freire e Vigotski, evidenciando o processo de humanização como resultado das interações verbais e sociais que os indivíduos estabelecem em determinadas condições que caracterizam o espaço e o tempo em queestão inseridos e inserindo-se num processo ininterrupto. ABSTRACT:This article aims at analyzing the statement addressed to a farm child "Who do you think you are?" pointing to the fact that these children are responsible for their family income and as thisimmediate reality is intertwined by wires which build up their existence. This text is based on Bakhtin, Vygotsky and Freire, showing the process of humanization as a result of social and verbalinteractions which individuals establish under certain conditions in order to characterize the space and time in which they are inserted and inserting themselves into a never-ending process.

  8. Incidence and remission of parasomnias among adolescent children in the Tucson Children’s Assessment of Sleep Apnea (TuCASA Study

    Directory of Open Access Journals (Sweden)

    Furet O

    2011-06-01

    Full Text Available Background: Longitudinal assessments of parasomnias in the adolescent population are scarce. This analysis aims to identify the incidence and remission of parasomnias in the adolescent age group.Methods: The TuCASA study is a prospective cohort study that initially enrolled children between the ages of 6 and 11 years (Time 1 and subsequently re-studied them approximately 5 years later (Time 2. At both time points parents were asked to complete a comprehensive sleep habits questionnaire designed to assess the severity of sleep-related symptoms that included questions about enuresis (EN, sleep terrors (TR, sleep walking (SW and sleep talking (ST.Results: There were 350 children participating at Time 1 who were studied as adolescents at time 2. The mean interval between measurements was (4.6 years. The incidence of EN, TR, ST, and SW in these 10-18 year old children was 0.3%, 0.6%, 6.0% and 1.1% respectively. Remission rates were 70.8%, 100%, 64.8% and 50.0% respectively.Conclusions: The incidence rates of EN, TR, and SW were relatively low moving from childhood to adolescence while remission rates were high across all parasomnias.

  9. Daudzkanālu skaņas formātu izplatība un testēšanas rīki

    OpenAIRE

    Brēmers, Ronalds

    2014-01-01

    Mūsdienās mājas lietotāju vidū, stereo sistēmas tiek izmantotas visbiežāk, ko var secināt gan no statistikas par daudzkanālu audio formātu izplatību, kā arī paša pieredzes un tā, ka stereo sistēmas uzstādīšana un izmantošana prasa mazāk pūļu un resursus. Par spīti tam, filmu un mūzikas pilnai baudīšanai daudzi izvēlas tieši 5.1 vai 7.1 audio sistēmas konfigurāciju, kurām ir savi trūkumi, kā pareizas uzstādīšanas un konfigurēšanas problēmas, tā arī, galvenokārt, legāla satura iegūšanas grūtība...

  10. Perceptions populaires du risque et savoirs experts en contexte de pandémie : le cas du A(H1N1 au Québec. Public perceptions of risk and expert knowledge in times of pandemic disease: the cases of A (H1N1 in Quebec.

    Directory of Open Access Journals (Sweden)

    Michel Désy

    2011-11-01

    Full Text Available La pandémie A(H1N1 de 2009 a mis en évidence les limites des stratégies de communication du risque tout en ravivant l’intérêt pour une analyse des perceptions populaires du risque. Au Québec, la campagne de vaccination de l’automne 2009 fut le théâtre de la circulation d’informations perçues souvent comme contradictoires sur le risque épidémique. Dans le cadre de dix focus groups organisés à Montréal et à Québec dans les mois qui ont suivi la fin de la campagne de vaccination, 100 Québécois francophones ont été invités à débattre de leur perception tant du risque associé au virus et au vaccin que de la gestion qui en fut faite par les autorités de santé publique. L’article analyse ces perceptions, en illustre la diversité et montre que diverses logiques cohabitent dans un savoir populaire marqué d’une certaine réflexivité. L’article conclut sur certaines leçons à tirer pour les stratégies de communication du risque épidémique.The A(H1N1 pandemic of 2009 illustrated the limitations of communication strategies on risk and revived interest in the analysis of public perception of risk. In Quebec, during the vaccination campaign carried out in the fall of 2009, the spread of information on epidemiological risk was often perceived as contradictory. In the months following the vaccination campaign, 10 focus groups were organized in Montréal and Québec City and 100 French-speaking Quebecers were invited to discuss their perception of the risk associated with the virus and vaccination, the management of the situation by public health authorities and the pertinence of holding a public consultation in the context of a pandemic disease. The article presents the different opinions of the general public tempered, however, by a measure of reflexivity. The article concludes with lessons to be learned regarding communication strategies on epidemiological risk.

  11. Sonder le cerveau pour savoir comment il apprend | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    29 nov. 2017 ... Highlight: Pioneer of oral rehydration therapy visits IDRC's Asia regional office in Delhi. Dr Richard A. Cash was a guest lecturer at the IDRC Asia ... The 14th World Congress on Public Health was held from February 11 to 15, 2015, at Science City, Kolkata, India.This year's theme was "Healthy Peop.

  12. Learning more about plutonium; En savoir plus sur le plutonium

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    This digest brochure explains what plutonium is, where it comes from, how it is used, its recycling into Mox fuel, its half life, historical discovery, its presence in the environment, toxicity and radioactivity. (J.S.)

  13. Learning more about radioactivity; En savoir plus sur la radioactivite

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    This digest brochure explains what radioactivity is, where it comes from, how it is measured, what are its effects on the body and the way to protect it against these effects, the uses of radioactivity (In the medical field, In industry, In the food industry, and In the cultural world). It ends with some examples of irradiation levels, of natural radioactivity and with the distribution in France of various sources of exposure. (J.S.)

  14. Savoir Fluide. A newsletter on computational hydraulics and fluid dynamics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This newsletter reports on computational works performed by the National Laboratory of Hydraulics (LNH) from Electricite de France (EdF). Two papers were selected which concern the simulation of the Paluel nuclear power plant plume and the computation of particles and droplets inside a cooling tower. (J.S.).

  15. Les chemins du savoir | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Quand la démocratie bat de l'aile dans un pays, tout débat devient très partisan. Le CIES tente de fournir de l'information permettant aux responsables des politiques et à ceux qui façonnent l'opinion publique d'examiner les questions de manière plus impartiale. —Carlos Eduardo Aramburú, ancien directeur général, CIES ...

  16. All about nuclear sciences; Tout savoir sur le nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Le Blanc, A. [CEA Saclay DSM-SAC/USL2TI/STI/SVI, 91 - Gif-sur-Yvette (France)

    2009-07-01

    This French/English flyer, made by the French INIS team of CEA-Saclay, presents the INIS information system, the coverage and content of the database and makes the promotion of the opening of the database to free access through the web link: http://inisdb2.iaea.org/. (J.S.)

  17. Savoir Fluide. A newsletter on computational hydraulics and fluid dynamics

    International Nuclear Information System (INIS)

    1997-01-01

    This newsletter reports on computational works performed by the National Laboratory of Hydraulics (LNH) from Electricite de France (EdF). Two papers were selected which concern the simulation of the Paluel nuclear power plant plume and the computation of particles and droplets inside a cooling tower. (J.S.)

  18. Protection des droits communautaires sur le savoir traditionnel ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Peu de recherches ont été effectuées dans cet important domaine, et il n'y a guère d'exemples concrets d'accès aux ressources génétiques et de partage juste et équitable des avantages pouvant servir de modèles ... Gender and Taxation : Improving Revenue Generation and Social Protection in Developing Countries.

  19. La voie vers l'harmonie : savoir partager les ressources

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cathy Egan

    Le défi sur le plan du développement : apprendre de la discorde. Sur les fameuses îles Galápagos, en Équateur, les pêcheurs, les touristes et les écologistes ne s'entendent pas sur le sort des poissons : doit-on les pêcher, les photographier ou laisser libre cours à leur existence ? Au Pérou, institutions publiques ...

  20. Sonder le cerveau pour savoir comment il apprend | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    29 nov. 2017 ... Si vous apprenez à quelqu'un à jouer du piano, cette personne peut-elle facilement transférer son haut niveau de compétence dans une autre sphère, comme l'apprentissage d'une langue ? Des chercheurs du Canada, d'Israël et de l'Inde estiment que la musique peut nous renseigner sur la capacité du ...

  1. "Savoir Fare": Are Cooking Skills a New Morality?

    Science.gov (United States)

    Coveney, John; Begley, Andrea; Gallegos, Danielle

    2012-01-01

    There has been a recent surge of interest in cooking skills in a diverse range of fields, such as health, education and public policy. There appears to be an assumption that cooking skills are in decline and that this is having an adverse impact on individual health and well-being, and family wholesomeness. The problematisation of cooking skills…

  2. Protection des droits communautaires sur le savoir traditionnel ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La phase III permettra à des chercheurs chinois, indiens et péruviens d'aborder des questions ayant trait à la biodiversité agricole, en accordant une place de choix au riz, au maïs et à la pomme de terre. D'autres chercheurs, en Inde, au Kenya et au Panama, se pencheront sur les plantes médicinales traditionnelles dans le ...

  3. Błędy kształtu, porowatość wewnętrzna, dokładność wymiarów liniowych staliwnych odlewów precyzyjnych w aspekcie ekologii ich wytwarzania

    Directory of Open Access Journals (Sweden)

    J. Tomasik

    2012-12-01

    Full Text Available Dokonano kompleksowej oceny jakości odlewów precyzyjnych przez badanie warstwy wierzchniej, ocenę błędu kształtu, dokładnościwymiarów liniowych. Badania wykonano w oparciu o nowoczesną aparaturę, miedzy innymi zastosowano maszynę pomiarową ZeissCalypso.Otrzymane wyniki badań pozwolą na zastosowanie optymalnej technologii wytwarzania odlewów w procesie wytapianych modeliw aspekcie ekologii.

  4. Odpovědnost státu za škodu způsobenou rozhodnutím nebo nesprávným úředním postupem

    OpenAIRE

    Šimáková, Eva

    2012-01-01

    Odpovědnost státu za škodu způsobenou rozhodnutím nebo nesprávným úředním postupem Abstrakt English Thesis is interested in a legal institution of state liability for damage incurred due to the decision or incorrect official procedure as one of the particular case of a civil liability. It evaluates its legal forms on the one hand and specifics of proceedings concerning compensation for damage on the other, de lege lata in the area of the Czech national law. The thesis offers an European sight...

  5. Annotated draft genome sequences of three species of Cryptosporidium: Cryptosporidium meleagridis isolate UKMEL1, C. baileyi isolate TAMU-09Q1 and C. hominis isolates TU502_2012 and UKH1

    OpenAIRE

    Ifeonu, Olukemi O.; Chibucos, Marcus C.; Orvis, Joshua; Su, Qi; Elwin, Kristin; Guo, Fengguang; Zhang, Haili; Xiao, Lihua; Sun, Mingfei; Chalmers, Rachel M.; Fraser, Claire M.; Zhu, Guan; Kissinger, Jessica C.; Widmer, Giovanni; Silva, Joana C.

    2016-01-01

    Human cryptosporidiosis is caused primarily by Cryptosporidium hominis, C. parvum and C. meleagridis. To accelerate research on parasites in the genus Cryptosporidium, we generated annotated, draft genome sequences of human C. hominis isolates TU502_2012 and UKH1, C. meleagridis UKMEL1, also isolated from a human patient, and the avian parasite C. baileyi TAMU-09Q1. The annotation of the genome sequences relied in part on RNAseq data generated from the oocyst stage of both C. hominis and C. b...

  6. Tu Salud ¡Sí Cuenta! Your Health Matters! A Community-wide Campaign in a Hispanic Border Community in Texas.

    Science.gov (United States)

    Heredia, Natalia I; Lee, MinJae; Mitchell-Bennett, Lisa; Reininger, Belinda M

    To evaluate a community-wide campaign, Tu Salud ¡Si Cuenta! (TSSC), in improving eating behaviors and anthropometric outcomes in Hispanic border communities. A quasi-experimental study with matched intervention and comparison communities. Cross-sectional assessments with randomly sampled adults, examined by actual exposure and site (unexposed intervention, exposed intervention, and unexposed comparison). Predominately Mexican Americans located in Brownsville, TX (intervention) and Laredo, TX (control). The TSSC campaign included television and radio segments, community health worker discussions, and newsletters delivered in Brownsville from 2005 to 2010. Healthy and unhealthy eating indices and average hip and waist circumferences. Univariable and multivariable regression models. The sample (n = 799; 400 comparison and 399 intervention) was 98% of Mexican origin; 54% had completed grade 9 or higher. Exposure to any TSSC component was associated with a lower rate of unhealthy food consumption. Compared with the unexposed intervention group, the exposed intervention for the newsletter had a higher rate of healthy eating (adjusted rate ratio = 1.18; P < .01). Compared with the unexposed intervention, the exposed intervention for the community health worker discussion had a smaller hip circumference (adjusted mean difference = -5.77 cm; P < .05) and a smaller waist circumference (adjusted mean difference = -5.25 cm; P < .05). This study provides evidence for the use of community-wide campaigns for nutrition and obesity-related outcomes in Hispanic communities. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

  7. Kļūdu analīze Latvijas pilsētu tīmekļa vietņu tulkojumos vācu valodā

    OpenAIRE

    Surova, Jevgeņija

    2015-01-01

    Maģistra darba „Kļūdu analīze Latvijas pilsētu tīmekļa vietņu tulkojumos vācu valodā” mērķis ir sniegt ieguldījumu tūrisma jomas tekstu tulkošanas uzlabošanā, kā arī izstrādāt ieteikumus tūrisma tekstu tulkotājiem svešvalodā, norādot uz būtiskākajām kļūdām jeb nepilnībām. Šī mērķa sasniegšanai tika izvēlētas 10 Latvijas pilsētu un citas ar tūrismu saistītas tīmekļa vietnes, kuras pieejamas arī vācu valodā. Tulkojumi vācu valodā tika vērtēti un analizēti no vairākiem valodas un tulkošanas aspe...

  8. Banku loma noziedzīgi iegūtu līdzekļu legalizācijas un terorisma finansēšanas novēršanā

    OpenAIRE

    Beirote, Laura

    2017-01-01

    Bankas līdz pat šim brīdim ir bijušas lielākā privātā sektora pārstāves, kas ir veicinājušas naudas atmazgāšanas un terorisma finansēšanas atklāšanu, tādēļ autors ar šī darba palīdzību vēlas norādīt tieši uz banku nozīmīgo lomu noziedzīgi iegūtu līdzekļu legalizācijas un terorisma finansēšanas novēršanā. Valsts institūcijas nevar bez finanšu iestāžu starpniecības šādus nelikumīgus darījumus izsekot, un saukt pie kriminālās atbildības vainīgās personas. Darbā ir analizēts noziedzīgi iegūtu lī...

  9. Genotypic and phenotypic characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii sp. nov. (formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Acinetobacter genomic species 13TU).

    Science.gov (United States)

    Nemec, Alexandr; Krizova, Lenka; Maixnerova, Martina; van der Reijden, Tanny J K; Deschaght, Pieter; Passet, Virginie; Vaneechoutte, Mario; Brisse, Sylvain; Dijkshoorn, Lenie

    2011-05-01

    Acinetobacter genomic species (gen. sp.) 3 and gen. sp. 13TU are increasingly recognized as clinically important taxa within the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex. To define the taxonomic position of these genomic species, we investigated 80 strains representing the known diversity of the ACB complex. All strains were characterized by AFLP analysis, amplified rDNA restriction analysis and nutritional or physiological testing, while selected strains were studied by 16S rRNA and rpoB gene sequence analysis, multilocus sequence analysis and whole-genome comparison. Results supported the genomic distinctness and monophyly of the individual species of the ACB complex. Despite the high phenotypic similarity among these species, some degree of differentiation between them could be made on the basis of growth at different temperatures and of assimilation of malonate, l-tartrate levulinate or citraconate. Considering the medical relevance of gen. sp. 3 and gen. sp. 13TU, we propose the formal names Acinetobacter pittii sp. nov. and Acinetobacter nosocomialis sp. nov. for these taxa, respectively. The type strain of A. pittii sp. nov. is LMG 1035(T) (=CIP 70.29(T)) and that of A. nosocomialis sp. nov. is LMG 10619(T) (=CCM 7791(T)). Copyright © 2011 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

  10. Professional know-how and MSD prevention: conceptual and methodological reflection leading to their identification and the start of their construction Savoirs professionnels et prévention des TMS : réflexions conceptuelles et méthodologiques menant à leur identification et à la genèse de leur construction Saberes profesionales y prevención de LME : reflexiones conceptuales y metodológicas que conducen a su identificación y a la génesis de su construcción

    Directory of Open Access Journals (Sweden)

    Nicole Vézina

    2008-11-01

    Full Text Available Repetitive work is often seen as work that can be learned by simple observation of a colleague. This study aimed to describe the know-how and especially the know-how that can be used for one’s protection, developed by six expert workers in a meat-cutting department. Individual and group interviews, on-site and video observations, and individual auto-confrontation (confronting participants with their own activity were conducted. A typology of the know-how’s knowledge base was developed and the existence of a hierarchy in the development of expertise was brought to light, including know-how called « efficient know-how ». This hierarchy highlights all the complexity of the work that should be considered in organizing training and presenting content. The ergonomic approach developed in this study and a theoretical framework resulting from practice have helped to uncover the wealth of knowledge that is mobilized in manual labor.Le travail répétitif est souvent vu comme un travail qui peut s’apprendre par la simple observation d’un collègue. Cette étude a eu pour objectif de décrire les savoir-faire et en particulier ceux qui permettent de se protéger, qui sont développés par six travailleurs-experts d’un département de découpe de la viande. Des entretiens individuels et collectifs, des observations sur place et sur vidéos et des rencontres d’autoconfrontation ont été réalisés. Une typologie des savoirs à la base des savoir-faire a été élaborée et l’existence d’une hiérarchie dans la construction des savoir-faire a été dévoilée, notamment pour des savoir-faire appelés « savoir-faire efficients ». Cette hiérarchie fait ressortir toute la complexité du travail qui devrait être considérée dans l’organisation de la formation et la présentation du contenu. La démarche ergonomique développée dans cette étude ainsi qu’un cadre théorique issu de la pratique sur le terrain ont permis de mettre au

  11. Savoirs professionnels et prévention des TMS : réflexions conceptuelles et méthodologiques menant à leur identification et à la genèse de leur construction Professional know-how and MSD prevention: conceptual and methodological reflection leading to their identification and the start of their construction Saberes profesionales y prevención de LME : reflexiones conceptuales y metodológicas que conducen a su identificación y a la génesis de su construcción

    Directory of Open Access Journals (Sweden)

    Sylvie Ouellet

    2008-11-01

    Full Text Available Le travail répétitif est souvent vu comme un travail qui peut s’apprendre par la simple observation d’un collègue. Cette étude a eu pour objectif de décrire les savoir-faire et en particulier ceux qui permettent de se protéger, qui sont développés par six travailleurs-experts d’un département de découpe de la viande. Des entretiens individuels et collectifs, des observations sur place et sur vidéos et des rencontres d’autoconfrontation ont été réalisés. Une typologie des savoirs à la base des savoir-faire a été élaborée et l’existence d’une hiérarchie dans la construction des savoir-faire a été dévoilée, notamment pour des savoir-faire appelés « savoir-faire efficients ». Cette hiérarchie fait ressortir toute la complexité du travail qui devrait être considérée dans l’organisation de la formation et la présentation du contenu. La démarche ergonomique développée dans cette étude ainsi qu’un cadre théorique issu de la pratique sur le terrain ont permis de mettre au jour la richesse des savoirs mobilisés dans le travail manuel.Repetitive work is often seen as work that can be learned by simple observation of a colleague. This study aimed to describe the know-how and especially the know-how that can be used for one’s protection, developed by six expert workers in a meat-cutting department. Individual and group interviews, on-site and video observations, and individual auto-confrontation (confronting participants with their own activity were conducted. A typology of the know-how’s knowledge base was developed and the existence of a hierarchy in the development of expertise was brought to light, including know-how called « efficient know-how ». This hierarchy highlights all the complexity of the work that should be considered in organizing training and presenting content. The ergonomic approach developed in this study and a theoretical framework resulting from practice have helped to

  12. Should Degree Programs in Biomedical and Health Informatics be Dedicated or Integrated? : Reflections and Recommendations after more than 40 Years of Medical Informatics Education at TU Braunschweig, including 10 Years of B.Sc. and 15 Years of M.Sc. Integrated Degree Curricula.

    Science.gov (United States)

    Haux, Reinhold; Marschollek, Michael; Wolf, Klaus-Hendrik; Zeisberg, Ute

    2017-07-01

    Education in biomedical and health informatics (BMHI) has been established in many countries throughout the world. For degree programs in BMHI we can distinguish between those that are completely stand-alone or dedicated to the discipline vs. those that are integrated within another program. After running integrated degree medical informatics programs at TU Braunschweig for 10 years at the B.Sc. and for 15 years at the M.Sc level, we (1) report about this educational approach, (2) analyze recommendations on, implementations of, and experiences with degree educational programs in BMHI worldwide, (3) summarize our lessons learned with the integrated approach at TU Braunschweig, and (4) suggest an answer to the question, whether degree programs in biomedical and health informatics should be dedicated or integrated. According to our experience at TU Braunschweig and based on our analysis of publications, there is a clear dominance of dedicated degree programs in BMHI. The specialization in medical informatics within a computer science program, as offered at TU Braunschweig, may be a good way of implementing an integrated, informatics-based approach to medical informatics, in particular if a dual degree option can be chosen. The option of curricula leading to double degrees, i.e. in this case to two separate degrees in computer science and in medical informatics might, however, be a better solution.

  13. Izlaganje na javni uvid podataka o nekretninama i utvrđivanje prava na zemljištu u funkciji uspostave jedinstvenog registra zemljišta i prava na zemljištu u Brčko distriktu BiH : Public presentation of data on real-estate and determination of rights in function of the establishment of a single registry of real-estate and real rights to real-estate in the Brcko district of B&H

    Directory of Open Access Journals (Sweden)

    Faruk Latifović

    2014-12-01

    Full Text Available Zakon o registru zemljišta i prava na zemljištu Brčko distrikta Bosne i Hercegovine je propisao uspostavu jedinstvene evidencije nekretnina i stvarnih prava na nekretninama u Brčko distriktu Bosne i Hercegovine. Poslovi uspostave jedinstvene evidencije, u segmentu izlaganja na javni uvid podataka o nekretninama i utvrđivanje prava, su povjereni Vijeću za izlaganje podataka o nekretninama i utvrđivanje prava na zemljištu Brčko distrikta Bosne i Hercegovine. Autor se, u ovom radu, uz nezaobilazan kraći prikaz historijata javnih evidencija na nekretninama u Bosni i Hercegovini, bavi organizacijom, nadležnostima i načinom rada Vijeća za izlaganje podataka o nekretninama i utvrđivanje prava na zemljištu Brčko distrikta BIH. Nakon što bude uspješno okončan projekat izlaganje podataka o nekretninama i utvrđivanje prava na zemljištu u Brčko distriktu BiH, svi geodetsko – katastarski podaci o nepokretnostima kao i podaci o njihovom pravnom statusu će biti vođeni u Registru zemljišta i prava na zemljištu Osnovnog suda Brčko distrikta BiH. : The Law of Land Registry and Rights over Land of the Brčko District of B&H stipulated the establishment of a single registry of real-estate and real rights to real-estate in the Brčko District of B&H. Activities of the establishment of a single registry, in the segment of public presentation of data on real-estate and determination of rights, were entrusted to the Council for Presentation of Data on Real-estate and Establishment of Rights to Land of the Brčko District of B&H. In this paper, the author presents the inevitable short overview of the history of real-estate registries in Bosnia and Herzegovina and he also deals with organization, competencies and manner of work of the Council for Presentation of Data on Real-estate and Establishment of Rights to Land of the Brčko District of B&H. After a successful completion of the project of presentation of data on real-estate and

  14. Si estoy en tu recuerdo soy parte de tu historia

    OpenAIRE

    Boixader i Corominas, Agnès

    2008-01-01

    Partiendo de la constatación de que la historia es transmisora de actitudes, valores e ideología, siempre sujeta a interpretaciones nuevas, y partiendo, asimismo, del valor que tiene para la historia el recuerdo de algunos testimonios de los hechos, se justifica y expone una experiencia didáctica llevada a cabo con jóvenes de bachillerato.

  15. Luz, yo soy tu padre

    OpenAIRE

    Sánchez Martín, Rubén

    2013-01-01

    Se presenta un pack de autopromoción. Son un recurso común entre la comunidad creativa como forma de demostrar sus habilidades en diferentes formatos y buscar un contacto original y agradable con el receptor a la hora de considerar a un candidato para un puesto laboral o la concesión de un proyecto. Se abordan desde el diseño de packaging a la dirección de arte de vídeo, pasando por el diseño de publicaciones, la redacción creativa, la conceptualización, la creación de identidad visual, el di...

  16. TU Delft en online media

    NARCIS (Netherlands)

    Speekenbrink, R.J.H.

    2013-01-01

    Dit boek behandelt een visie op online media bij Nederlandse universiteiten. Daarbij beperk ik me tot die aspecten waarin online communicatie en/of online marketing een rol speelt. Dit boek behandelt niet de onderwijsgerelateerde aspecten van online media. Elektronische leeromgevingen, sociale media

  17. Les connaissances au quotidien : perceptions et savoirs des populations riveraines de l’Amazonie sur leurs ressources halieutiques Conhecimentos no cotidiano : percepções e saberes de populações ribeirinhas da Amazônia sobre seus recursos haliêuticos  Knowledge in everyday life: perceptions and knowledges of riparian Amazonian populations on their fishery resources

    Directory of Open Access Journals (Sweden)

    S. Paquet

    2011-12-01

    Full Text Available Dans cet article nous nous sommes intéressés à la la pêche vivrière et artisanale pratiquée par les riverains de l’Amazonie. Les résultats présentés, touchant le savoir traditionnel de ces populations, leurs perceptions des changements environnementaux et de l’évolution des ressources halieutiques, ainsi que les solutions à y apporter, proviennent de deux questionnaires administrés à douze communautés du bassin du Tapajós. Ces résultats apportent un nouvel éclairage sur les enjeux liés à la gestion des ressources halieutiques et soulèvent les lacunes empêchant une réele appropriationdes problèmes environnementaux et l’émergence locale de solutions. Nous avons en effet mis en évidence que le déboisement et l’érosion des berges étaient perçus comme les plus importants changements environnementaux observés au fil du temps. La diminution de l’abondance et/ou la réduction des tailles des poissons a également été signalée par les personnes rencontrées. Le manque de lien entre les changements observés sur les écosystèmes naturels et ceux observés sur la ressource halieutique a attiré notre attention. En conséquence, toute intervention visant l’élaboration et/ou l’implantion de méthodes durables d’exploitation des ressources halieutiques doit absolument passer par une activité préalable d’information. Ceci dans le but de générer une appropriation locale des problèmes environnementaux et de favoriser l’émergence de solutions au sein des communautés concernées.Nesse artigo nós nos interessamos a pesca artesanal praticada pelos ribeirinhos da Amazônia. Os resultados apresentados, tocando o saber tradicional dessas populações, suas percepções sobre as mudanças ambientais e a evolução dos recursos haliêuticos, assim como as soluções para essas mudanças, provêm da análise de dois questionários aplicados em doze comunidades da bacia do Tapajós. Esses resultados lançam uma

  18. Maestros narrados en el cine.Una mirada entreabierta sobre la escuela, el saber y la formación (Teachers in Cinema. A Half-open Perspective of Schools, Knowledge and Education (Mestres narrados no cinema. Um olhar entreaberto sobre a escola, o saber e a formação(Maîtres narrateurs dans le cinéma. Un regard entrouvert sur l′école, le savoir et la formation

    Directory of Open Access Journals (Sweden)

    Érica Elexandra Areiza-Pérez

    2011-12-01

    Full Text Available ResumenEl texto realiza una reflexión pedagógica a partir de tres producciones cinematográficas, a saber, Estrellas del cielo sobre la tierra, Rojo como el cie- lo y La sonrisa de Mona Lisa. El foco de atención de esta reflexión tiene relación con la figura del maestro y con el modo en que acoge o entorpe- ce el proyecto humano de sus estudiantes. Tam- bién se exploran algunas tensiones propias del escenario educativo y el lugar del saber en los procesos de formación.AbstractThis paper approaches pedagogy adressing three cinematographical productions: Like Stars on Earth, Red Like the Sky and Mona Lisa Smile, focusing on the teacher characters and how they welcome or hinder the life plans of their students. Also, some tensions of education scenes and the role of knowledge in education processes are explored.RésuméLe texte réalise une réflexion pé- dagogique à partir de trois pro- ductions cinématographiques, telles que, Une étoile du ciel dans la terre, Rouge comme le ciel, Le sourire de Mona Lisa. Le focus de concentration de cette réflexion s'agit de la figure du maître et la manière dans laquelle il accueille ou il empêche le projet humain de ses étudiants. Par ailleurs, on explore les tensions propres de la scène éducative et le lieu du savoir dans les processus de formation.ResumoO texto realiza uma reflexão peda- gógica a partir de três produções cinematográficas: Uma estrela do céu na terra, Vermelho como o céu e O sorriso de Mona Lisa. O foco central desta reflexão está re- lacionado à figura do mestre e ao modo como acolhe ou entorpece o projeto humano de seus estu- dantes. O artigo também explora algumas tensões próprias do ce- nário educativo e o lugar do saber nos processos de formação.

  19. Assessing the effectiveness of a patient-centred computer-based clinic intervention, Health-E You/Salud iTu, to reduce health disparities in unintended pregnancies among Hispanic adolescents: study protocol for a cluster randomised control trial.

    Science.gov (United States)

    Tebb, Kathleen P; Rodriguez, Felicia; Pollack, Lance M; Trieu, Sang Leng; Hwang, Loris; Puffer, Maryjane; Adams, Sally; Ozer, Elizabeth M; Brindis, Claire D

    2018-01-10

    Teen pregnancy rates in the USA remain higher than any other industrialised nation, and pregnancies among Hispanic adolescents are disproportionately high. Computer-based interventions represent a promising approach to address sexual health and contraceptive use disparities. Preliminary findings have demonstrated that the Health-E You/Salud iTu, computer application (app) is feasible to implement, acceptable to Latina adolescents and improves sexual health knowledge and interest in selecting an effective contraceptive method when used in conjunction with a healthcare visit. The app is now ready for efficacy testing. The purpose of this manuscript is to describe patient-centred approaches used both in developing and testing the Health-E You app and to present the research methods used to evaluate its effectiveness in improving intentions to use an effective method of contraception as well as actual contraceptive use. This study is designed to assess the effectiveness of a patient-centred computer-based clinic intervention, Health-E You/Salud  iTu, on its ability to reduce health disparities in unintended pregnancies among Latina adolescent girls. This study uses a cluster randomised control trial design in which 18 school-based health centers from the Los Angeles Unified School District were randomly assigned, at equal chance, to either the intervention ( Health-E You app) or control group. Analyses will examine differences between the control and intervention group's knowledge of and attitudes towards contraceptive use, receipt of contraception at the clinic visit and self-reported use of contraception at 3-month and 6-month follow-ups. The study began enrolling participants in August 2016, and a total of 1400 participants (700 per treatment group) are expected to be enrolled by March 2018. Ethics approval was obtained through the University of California, San Francisco Institutional Review Board. Results of this trial will be submitted for publication in peer

  20. Biscuits with No Added Sugar Containing Stevia, Coffee Fibre and Fructooligosaccharides Modifies α-Glucosidase Activity and the Release of GLP-1 from HuTu-80 Cells and Serotonin from Caco-2 Cells after In Vitro Digestion

    Science.gov (United States)

    Martinez-Saez, Nuria; Hochkogler, Christina Maria; Somoza, Veronika; del Castillo, Maria Dolores

    2017-01-01

    This study assessed the in vitro effects of the bioaccessible food components released during the simulated human digestion of a coffee fibre-containing biscuit (CFB) on α-glucosidase activity, antioxidant capacity and satiety hormones. Digest of CFB presented a significantly (p < 0.05) lower amount of sugar (68.6 mg/g) and a higher antioxidant capacity (15.1 mg chlorogenic acid eq./g) than that of a sucrose-containing biscuit (SCB). The CFB significantly reduced (p < 0.05) α-glucosidase activity (IC50 = 3.3 mg/mL) compared to the SCB (IC50 = 6.2 mg/mL). Serotonin and glucagon-like peptide-1 (GLP-1) release by differentiated Caco-2 and HuTu-80 cells, respectively, was stimulated by the CFB (355% at a concentration of 0.5 mg/mL and 278% at a concentration of 0.05 mg/mL) to the same order of magnitude as those of the SCB. To summarize, the CFB was demonstrated to reduce monosaccharide bioaccessibility, to inhibit a diabetes-related digestive enzyme, and to improve the release of satiety hormones. PMID:28677657

  1. ESCARIFICAÇÃO ÁCIDA NA SUPERAÇÃO DA DORMÊNCIA DE SEMENTES DE PAU FERRO (Caesalpinea ferrea Mart.ex Tu. var. leiostachya Benth.

    Directory of Open Access Journals (Sweden)

    Edna Ursulino Alves

    2009-01-01

    Full Text Available Seeds of Caesalpinea ferrea Mart. ex Tu. var. leiostachya Benth. present low and irregular germination due to dormancy caused by the impermeability of the tegument. With the purpose to determine an efficient method to accelerate and uniformize seed germination, they were submitted to different immersion periods (0, 5, 10, 15, 20, 25 and 30 minutes in sulfuric acid (95-98%, influence emergency and vigor (first count, speed index, medium time and relative frequency of emergency, length and dry matter of the seedlings. The experiment was carried out under greenhouse conditions with an experimental design of completely randomized, with seven treatments and four replications. The pre-conditioning of the seeds with immersion in concentrated sulfuric acid was efficient to overcoming seed dormancy, by increasing the percentage and speed emergency, the first count of emergency, length and dry matter of seedlings and reduction in the medium time for emergency. The efficiency of this chemical treatment with concentrated sulfuric depends on the immersion time, and 10 to 20 minutes were the most adequate to provide larger emergency uniformity percentages and vigor.

  2. Biscuits with No Added Sugar Containing Stevia, Coffee Fibre and Fructooligosaccharides Modifies α-Glucosidase Activity and the Release of GLP-1 from HuTu-80 Cells and Serotonin from Caco-2 Cells after In Vitro Digestion.

    Science.gov (United States)

    Martinez-Saez, Nuria; Hochkogler, Christina Maria; Somoza, Veronika; Del Castillo, Maria Dolores

    2017-07-04

    This study assessed the in vitro effects of the bioaccessible food components released during the simulated human digestion of a coffee fibre-containing biscuit (CFB) on α-glucosidase activity, antioxidant capacity and satiety hormones. Digest of CFB presented a significantly ( p < 0.05) lower amount of sugar (68.6 mg/g) and a higher antioxidant capacity (15.1 mg chlorogenic acid eq./g) than that of a sucrose-containing biscuit (SCB). The CFB significantly reduced ( p < 0.05) α-glucosidase activity (IC50 = 3.3 mg/mL) compared to the SCB (IC50 = 6.2 mg/mL). Serotonin and glucagon-like peptide-1 (GLP-1) release by differentiated Caco-2 and HuTu-80 cells, respectively, was stimulated by the CFB (355% at a concentration of 0.5 mg/mL and 278% at a concentration of 0.05 mg/mL) to the same order of magnitude as those of the SCB. To summarize, the CFB was demonstrated to reduce monosaccharide bioaccessibility, to inhibit a diabetes-related digestive enzyme, and to improve the release of satiety hormones.

  3. Annotated draft genome sequences of three species of Cryptosporidium: Cryptosporidium meleagridis isolate UKMEL1, C. baileyi isolate TAMU-09Q1 and C. hominis isolates TU502_2012 and UKH1.

    Science.gov (United States)

    Ifeonu, Olukemi O; Chibucos, Marcus C; Orvis, Joshua; Su, Qi; Elwin, Kristin; Guo, Fengguang; Zhang, Haili; Xiao, Lihua; Sun, Mingfei; Chalmers, Rachel M; Fraser, Claire M; Zhu, Guan; Kissinger, Jessica C; Widmer, Giovanni; Silva, Joana C

    2016-10-01

    Human cryptosporidiosis is caused primarily by Cryptosporidium hominis, C. parvum and C. meleagridis. To accelerate research on parasites in the genus Cryptosporidium, we generated annotated, draft genome sequences of human C. hominis isolates TU502_2012 and UKH1, C. meleagridis UKMEL1, also isolated from a human patient, and the avian parasite C. baileyi TAMU-09Q1. The annotation of the genome sequences relied in part on RNAseq data generated from the oocyst stage of both C. hominis and C. baileyi The genome assembly of C. hominis is significantly more complete and less fragmented than that available previously, which enabled the generation of a much-improved gene set for this species, with an increase in average gene length of 500 bp relative to the protein-encoding genes in the 2004 C. hominis annotation. Our results reveal that the genomes of C. hominis and C. parvum are very similar in both gene density and average gene length. These data should prove a valuable resource for the Cryptosporidium research community. © FEMS 2016.

  4. Los narûs (kudurrus babilónicos del Bronce Final y el Hierro = The Babylonian narû (kudurrētu in Late Bronze and Iron Age

    Directory of Open Access Journals (Sweden)

    Sara Arroyo Cuadra

    2016-11-01

    Full Text Available Los narû babilónicos, conocidos tradicionalmente con el nombre de kudurrētu (en singular kudurru, fueron unos monumentos de piedra que incluían representaciones divinas encarnadas generalmente por sus emblemas y escenas con figuras antropomorfas, junto a un texto administrativo sobre transacciones  de tierras. Estos narû vieron la luz con la Dinastía Casita de Babilonia y dejaron de utilizarse en el período Neo-babilónico (ca. 1400-650 a.C.. La gran mayoría de los ejemplares se ha descubierto en Susa en contextos arqueológicos descontextualizados, pero los ejemplares hallados in situ nos hablan de que su dispersión geográfica original hay que situarla en el territorio de la Baja Mesopotamia. Hemos emprendido una investigación orientada a estudiar el corpus de estos monumentos integrado hasta el momento por 178 ejemplares, adoptando una postura interdisciplinar que incluye el análisis de la información que transmiten sus textos, iconografía, materialidad y contexto arqueológico. Por ello, a lo largo del presente artículo se intentará definir el criterio de adscripción de los ejemplares conocidos a dicho corpus según sus propias inscripciones y los estudios previos de  otros autores. A continuación, se hablará de las circunstancias que pudieron motivar su aparición y de los eventos histórico-políticos que pudieron influir en su evolución, así como del ámbito geográfico en que estuvieron vigentes. Después, se analizará el contenido de sus inscripciones y la simbología de su iconografía para, aportar, finalmente, un estudio comparativo entre textos y símbolos, quedando todo ello plasmado en un apartado final de conclusiones.Babylonian narû, traditionally named kudurrētu, were stone monuments with divine representations (generally through its divine emblems and figurative scenes with anthropomorphic figures, together with an administrative text about a land grant. These narû originated in Kassite Babylon and

  5. Tu Salud, ¡Si Cuenta!: Exposure to a community-wide campaign and its associations with physical activity and fruit and vegetable consumption among individuals of Mexican descent.

    Science.gov (United States)

    Reininger, Belinda M; Mitchell-Bennett, Lisa; Lee, MinJae; Gowen, Rose Z; Barroso, Cristina S; Gay, Jennifer L; Saldana, Mayra Vanessa

    2015-10-01

    Mexican Americans along the US-Mexico border have been found to be disproportionately affected by chronic diseases particularly related to lack of physical activity and healthful food choices. A community-wide campaign (CWC) is an evidence-based strategy to address these behaviors but with few examples of implementation in Mexican descent populations facing profound health disparities. We examined exposure to a CWC, titled Tu Salud ¡Sí Cuenta!, and its association with meeting the recommended minutes of moderate and vigorous physical activity weekly and consuming more portions of fruits and vegetables daily. A cross-sectional sample of 1438 Mexican descent participants was drawn from a city-wide, randomly-selected cohort interviewed between the years 2008 and 2012. Multivariable comparisons of participants exposed and not exposed to the CWC and meeting physical activity guidelines or their fruit and vegetable consumptions using mixed effects models were conducted. The community-wide campaign components included different forms of mass media and individually-focused components such as community health worker (CHW) home visits. After adjusting for gender, age, marital status, educational attainment, language preference, health insurance, and diabetes diagnosis, the strongest association was found between meeting physical activity guidelines and exposure to both CHW discussions and radio messages (adjusted OR = 3.83; 95% CI = [1.28, 6.21]; p = 0.0099). Participants who reported exposure to both radio and TV messages consumed more portions of fruits and vegetables than those who reported no exposure (adjusted RR = 1.30; 95% CI = [1.02, 1.66]; p = 0.0338). This study provides insights into the implementation and behavioral outcomes associated with exposure to a community-wide campaign, a potential model for addressing lifestyle modifications in populations affected by health disparities. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Reclaiming streets for outdoor play: A process and impact evaluation of "Juega en tu Barrio" (Play in your Neighborhood, an intervention to increase physical activity and opportunities for play.

    Directory of Open Access Journals (Sweden)

    Andrea Cortinez-O'Ryan

    Full Text Available New strategies are required to create supportive physical and social environments for children and promote active free-play. Juega en tu Barrio (JETB; Play in your Neighborhood was designed and implemented to explore the effectiveness of closing a street in a low-to-middle income neighborhood in order to increase children's outside play and physical activity.A pretest-posttest design with control group was employed to investigate the intervention effects in a subsample of 100 children, 51 from the intervention neighborhood and 49 from the control neighborhood. The children wore pedometers for one week, and their parents completed questionnaires at two time points: before the intervention began and during the last two weeks of the intervention. JETB was conducted in the intervention neighborhood from 17:30 to 20:30, twice a week, from September to December 2014. Stewards ensured that the children were safe. Children and adults were assessed using systematic observation.The intervention and control neighborhoods included 177 and 116 children respectively. The average attendance per event was 60 children (SD = 22, reach 34%. In the intervention neighborhood, a significant increase between baseline and final assessment was observed in after-school outdoor playtime (p = 0.02, steps during the 3-hour intervention (p = 0.004, and daily steps Monday to Sunday (p = 0.006. Meanwhile, no changes were observed in the control neighborhood for the same variables. The proportion of children who met recommended daily step counts increased from 27.5% to 53.0% in the intervention neighborhood (p = 0.007, while for control neighborhood no difference was observed (49.0% to 53.0% p = 0.804.JETB showed high community engagement while offering opportunities for increased outdoor play in children. The intervention showed a significant effect on the number of children meeting the daily pedometer-derived physical activity recommendations.

  7. Chair in open-cast and international mining at the Institute for Mining at Clausthal Technological University; Lehrstuhl fuer Tagebau und Internationaler Bergbau am Institut fuer Bergbau der TU Clausthal

    Energy Technology Data Exchange (ETDEWEB)

    Tudeshki, H.; Hardebusch, T. [Lehrstuhl fuer Tagebau und Internationaler Bergbau am Institut fuer Bergbau, TU Clausthal-Zellerfeld (Germany)

    2002-12-05

    The range of activities of the Chair in Open-cast and International Mining at the Institute for Mining at Clausthal Technological University currently comprises the field of teaching and further scientific training, research and development as well as transfer of knowledge and technology. In addition to these legally sanctioned activities PR work concerning the necessity for the mining of mineral raw materials and the associated training of mining engineers plays a central role. In accordance with the fundamental idea that a prerequisite for good training in the field of engineering science is a close link between university and industry the contents of the courses are always adapted to the state of the art in the mining industry and the main areas of research based on practical requirements. In accordance with this process current aspects of the safeguarding of raw materials, sustenance and management of knowledge in the mining industry are integrated in these courses. The current research work is interdisciplinary and deals with quality management, deposit protection, recultivation and rehabilitation as well as reduction of emissions. (orig.) [German] Das Aufgabenspektrum des Lehrstuhls fuer Tagebau und Internationalen Bergbau am Institut fuer Bergbau der TU Clausthal umfasst die Gebiete Lehre und wissenschaftliche Weiterbildung, Forschung und Entwicklung sowie Wissens- und Technologietransfer. Ueber diese gesetzlich verankerten Aufgaben hinaus nimmt die PR-Arbeit ueber die Notwendigkeit bergmaennischer Gewinnung mineralischer Rohstoffe und der damit einhergehenden Ausbildung von Bergbauingenieuren eine zentrale Stellung ein. Dem Leitgedanken folgend, dass eine gute Ausbildung im ingenieurwissenschaftlichen Bereich eine enge Verbindung zwischen Hochschule und Industrie voraussetzt, werden die Lehrinhalte stets dem Stand der Technik im Bergbau angepasst und die Forschungsschwerpunkte praxisbezogen abgeleitet. Diesem Prozess folgend wurden aktuell Aspekte der

  8. Savoirs mondains, savoirs savants : les femmes et leurs cabinets de curiosités au siècle des Lumières

    Directory of Open Access Journals (Sweden)

    Adeline Gargam

    2010-01-01

    Full Text Available Dans la France des Lumières, la culture de la curiosité est un phénomène de mode mais surtout un jeu social et intellectuel. La présente étude entend retracer l’histoire d’une trentaine de cabinets féminins de curiosité tenus à cette époque. Des femmes fortunées de l’aristocratie et de la bourgeoisie parisienne et provinciale ont alors constitué sous l’emprise de leur libido sciendi des cabinets d’alchimie, de minéralogie, de physique‑chimie, d’histoire naturelle et d’anatomie naturelle et artificielle. Ces cabinets obéissent à une typologie particulière. Il en existe deux catégories : les cabinets d’amateurs, constitués pour la parade et le spectacle des visiteurs et fonctionnant comme de véritables écoles de plaisirs intellectuels et éducatifs ; les cabinets à finalité scientifique et didactique, formés par des savantes expérimentées qui se livrent dans leurs laboratoires à des recherches personnelles et expérimentales au nom des progrès de la science médicale et de l’instruction publique. La réflexion porte aussi sur le fonctionnement de ces cabinets privés de curiosité, particulièrement sur leur mode de constitution, leur décor intérieur ainsi que sur le contenu des collections qui nécessitaient certaines techniques d’organisation, d’acquisition et de conservation communes à celles de leurs homologues masculins.During the Enlightenment in France, curiosity culture constituted both a fashion and an intellectual and social game.  This article explores thirty cabinets of  curiosities run by women during this period. Wealthy women from the Parisiain and provincial aristocracy and middle classes organized cabinets in alchemy, mineralogy, physics and chemistry, natural history and biology studies. These cabinets can be divided into two distinct categories. The first represented amateur interests; they were developed for show and served as schools for intellectual and éducational pleasure. The second category were run by experienced women scientists who used their laboratories to conduct experimental research in the name of medical progress and public instruction. This article also describes how these private cabinets functioned, their composition, their interior décor as well as the contents of the collections, which required the organisation, acquisition and preservation techniques used in their male counterparts.

  9. İnternet ve Tuğla-Harç Mağazalarına İlişkin Müşteri Düşünceleri ve Değişen Müşteri Davranışları

    Directory of Open Access Journals (Sweden)

    Abdolrazagh MADAHI

    2014-09-01

    Full Text Available Bu çalışma Malezya’da internette faaliyet gösteren tuğla harç mağazalarına ilişkin müşteri düşüncelerini ve müşterilerin değişen kanal eğilimlerini analiz etmeyi amaçlamaktadır. Çalışmaya ilişkin veriler Klang Vadisi ve Penang Bölgesi’nde 497 kişinin katılımıyla gerçekleştirilen anketlerin neticesinde elde edilmiştir. Çalışmada yapısal bağlamda PLS Modeli ve data analizi bağlamında ise SEM Modeli kullanılmıştır. Yapılan 497 anketin neticesinde, çalışmanın verileri, uygunluk ve zorluk bağlamında internetten tuğla ve harç mağazalara doğru değişen bir eğilim olduğunu göstermiştir. Bulgular benzer şekilde cinsiyet ve niyetin de müşterilerin kanal değiştirmesinde etkin unsurlar olduğunu ortaya koymuştur.

  10. Determination, by using GPR, of the volumetric water content in structures, sub-structures, foundations and soil - ongoing activities in Working Project 2.5 of COST Action TU1208

    Science.gov (United States)

    Tosti, Fabio; Slob, Evert

    2015-04-01

    This work will endeavour to review the current status of research activities carried out in Working Project 2.5 'Determination, by using GPR, of the volumetric water content in structures, sub-structures, foundations and soil' within the framework of Working Group 2 'GPR surveying of pavements, bridges, tunnels and buildings; underground utility and void sensing' of the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' (www.GPRadar.eu). Overall, the Project includes 55 Participants from over 21 countries representing 33 Institutions. By considering the type of Institution, a percentage of 64% (35 units) comes from the academic world, while Research Centres and Companies include, respectively, the 27% (15 units) and 9% (5 units) of Institutions. Geographically speaking, Europe is the continent most represented with 18 out of 21 countries, followed by Africa (2 countries) and Asia (1 country). In more details and according to the Europe sub-regions classification provided by the United Nations, Southern Europe includes 39% of countries, Western Europe 27%, while Northern and Eastern Europe are equally present with 17% of countries each. Relying on the main purpose of Working Project 2.5, namely, the ground-penetrating radar-based evaluation of volumetric water content in structures, substructures , foundations, and soils, four main issues have been overall addressed over the first two years of activities. The first one, has been related to provide a comprehensive state of the art on the topic, due to the wide-ranging applications covered in the main disciplines of civil engineering, differently demanding. In this regard, two main publications reviewing the state of the art have been produced [1,2]. Secondly, discussions among Working Group Chairs and other Working Project Leaders have been undertaken and encouraged to avoid the risk of overlapping amongst similar topics from other Working

  11. Dynamique des savoirs et des échanges d’un produit de collecte en territoire transfrontalier Dinâmicas de conhecimentos e trocas de uma fruta de palmeira numa região fronteiriça. O caso do açaí (Euterpe oleracea Mart. na região do baixo Oiapoque Dynamics of knowledge and exchanges of a non timber forest product in border territory. The case of açai (Euterpe oleracea Mart. in the Lower Oyapock

    Directory of Open Access Journals (Sweden)

    Laval Pauline

    2012-11-01

    Full Text Available Le palmier wassaï (Euterpe oleracea Mart., aussi appelé açaí au Brésil et pinot en Guyane, est natif du bassin amazonien, en Amérique du Sud. Dans cette région, il est d’une importance alimentaire majeure. En effet, on peut tirer de ses fruits un nectar très riche qui constitue une part importante de la consommation de certains peuples d’Amazonie, notamment pendant la période de fructification du palmier. Ce nectar est désormais à la mode en milieu urbain au Brésil, et s’exporte sous une large gamme de produits dérivés à l’international, grâce à ses vertus énergétiques et anti-oxydantes reconnues. Si la majeure partie de la production et de la transformation de wassaï se déroule à Belém, dans l’Etat du Pará au Brésil, de nombreuses autres filières existent à plus petite échelle, car le fruit comme le nectar, très périssables, supportent mal le transport. Cet article explicite la filière de production du nectar de wassaï du bas Oyapock, région frontalière entre la Guyane française et le Brésil. Nous étudions, du point de vue de l’ethnoécologie, les impacts de la frontière sur la dynamique des savoirs et des échanges du wassaï. Plus de 100 entretiens semi-directifs ont été menés chez les différents groupes ethniques du bas Oyapock, ainsi que des travaux d’observation participante de localisation des zones de croissance du wassaï, et un lexique spécialisé trilingue a été réalisé. Les résultats révèlent une très grande diversité de savoirs, de savoir-faire et d’usages de ce palmier, parmi les 9 groupes ethniques recensés dans la région. Ces usages sont le plus souvent spécifiques à chaque groupe, et en perte de vitesse, sauf la consommation de nectar, qui est commune à tous les groupes ethniques, en augmentation générale. Les savoirs et techniques consacrés à la domestication et à la préparation du nectar sont explicités. Dans le but de comprendre la répartition du

  12. TU-AB-204-04: Partnerships

    Energy Technology Data Exchange (ETDEWEB)

    Ochs, R. [Food & Drug Administration Center for Devices and Radiological Health (United States)

    2016-06-15

    The responsibilities of the Food and Drug Administration (FDA) have increased since the inception of the Food and Drugs Act in 1906. Medical devices first came under comprehensive regulation with the passage of the 1938 Food, Drug, and Cosmetic Act. In 1971 FDA also took on the responsibility for consumer protection against unnecessary exposure to radiation-emitting devices for home and occupational use. However it was not until 1976, under the Medical Device Regulation Act, that the FDA was responsible for the safety and effectiveness of medical devices. This session will be presented by the Division of Radiological Health (DRH) and the Division of Imaging, Diagnostics, and Software Reliability (DIDSR) from the Center for Devices and Radiological Health (CDRH) at the FDA. The symposium will discuss on how we protect and promote public health with a focus on medical physics applications organized into four areas: pre-market device review, post-market surveillance, device compliance, current regulatory research efforts and partnerships with other organizations. The pre-market session will summarize the pathways FDA uses to regulate the investigational use and commercialization of diagnostic imaging and radiation therapy medical devices in the US, highlighting resources available to assist investigators and manufacturers. The post-market session will explain the post-market surveillance and compliance activities FDA performs to monitor the safety and effectiveness of devices on the market. The third session will describe research efforts that support the regulatory mission of the Agency. An overview of our regulatory research portfolio to advance our understanding of medical physics and imaging technologies and approaches to their evaluation will be discussed. Lastly, mechanisms that FDA uses to seek public input and promote collaborations with professional, government, and international organizations, such as AAPM, International Electrotechnical Commission (IEC), Image Gently, and the Quantitative Imaging Biomarkers Alliance (QIBA) among others, to fulfill FDA’s mission will be discussed. Learning Objectives: Understand FDA’s pre-market and post-market review processes for medical devices Understand FDA’s current regulatory research activities in the areas of medical physics and imaging products Understand how being involved with AAPM and other organizations can also help to promote innovative, safe and effective medical devices J. Delfino, nothing to disclose.

  13. TU Delft expert judgment data base

    International Nuclear Information System (INIS)

    Cooke, Roger M.; Goossens, Louis L.H.J.

    2008-01-01

    We review the applications of structured expert judgment uncertainty quantification using the 'classical model' developed at the Delft University of Technology over the last 17 years [Cooke RM. Experts in uncertainty. Oxford: Oxford University Press; 1991; Expert judgment study on atmospheric dispersion and deposition. Report Faculty of Technical Mathematics and Informatics No.01-81, Delft University of Technology; 1991]. These involve 45 expert panels, performed under contract with problem owners who reviewed and approved the results. With a few exceptions, all these applications involved the use of seed variables; that is, variables from the experts' area of expertise for which the true values are available post hoc. Seed variables are used to (1) measure expert performance, (2) enable performance-based weighted combination of experts' distributions, and (3) evaluate and hopefully validate the resulting combination or 'decision maker'. This article reviews the classical model for structured expert judgment and the performance measures, reviews applications, comparing performance-based decision makers with 'equal weight' decision makers, and collects some lessons learned

  14. Tu primer paso hacia el empleo

    OpenAIRE

    Díaz Iglesias, Luis Javier

    2014-01-01

    Cita anual con los jóvenes universitarios que buscan su primera oportunidad laboral. Contiene: Un trato directo (p.19).-- Foroempleo en datos (p. 20).--Fomentando el empleo (p.21).-- Luis Javier Díaz Iglesias. La clave del éxito profesional es ser feliz en el trabajo (pp. 22-24)

  15. TuLiP : reshaping trust management

    NARCIS (Netherlands)

    Czenko, M.R.

    2009-01-01

    In today's highly distributed and heterogeneous world of the Internet, sharing resources has become an everyday activity of every Internet user. We buy and sell goods over the Internet, share our holiday pictures using facebook (TM), "tube" our home videos on You Tube (TM), and exchange our

  16. TU-AB-BRD-01: Process Mapping

    International Nuclear Information System (INIS)

    Palta, J.

    2015-01-01

    Current quality assurance and quality management guidelines provided by various professional organizations are prescriptive in nature, focusing principally on performance characteristics of planning and delivery devices. However, published analyses of events in radiation therapy show that most events are often caused by flaws in clinical processes rather than by device failures. This suggests the need for the development of a quality management program that is based on integrated approaches to process and equipment quality assurance. Industrial engineers have developed various risk assessment tools that are used to identify and eliminate potential failures from a system or a process before a failure impacts a customer. These tools include, but are not limited to, process mapping, failure modes and effects analysis, fault tree analysis. Task Group 100 of the American Association of Physicists in Medicine has developed these tools and used them to formulate an example risk-based quality management program for intensity-modulated radiotherapy. This is a prospective risk assessment approach that analyzes potential error pathways inherent in a clinical process and then ranks them according to relative risk, typically before implementation, followed by the design of a new process or modification of the existing process. Appropriate controls are then put in place to ensure that failures are less likely to occur and, if they do, they will more likely be detected before they propagate through the process, compromising treatment outcome and causing harm to the patient. Such a prospective approach forms the basis of the work of Task Group 100 that has recently been approved by the AAPM. This session will be devoted to a discussion of these tools and practical examples of how these tools can be used in a given radiotherapy clinic to develop a risk based quality management program. Learning Objectives: Learn how to design a process map for a radiotherapy process Learn how to perform failure modes and effects analysis analysis for a given process Learn what fault trees are all about Learn how to design a quality management program based upon the information obtained from process mapping, failure modes and effects analysis and fault tree analysis. Dunscombe: Director, TreatSafely, LLC and Center for the Assessment of Radiological Sciences; Consultant to IAEA and Varian Thomadsen: President, Center for the Assessment of Radiological Sciences Palta: Vice President of the Center for the Assessment of Radiological Sciences

  17. TuLiP : reshaping trust management

    OpenAIRE

    Czenko, M.R.

    2009-01-01

    In today's highly distributed and heterogeneous world of the Internet, sharing resources has become an everyday activity of every Internet user. We buy and sell goods over the Internet, share our holiday pictures using facebook (TM), "tube" our home videos on You Tube (TM), and exchange our interests and thoughts on blogs. We podcast, we are Linkedin (TM) to extend our professional network, we share files over P2P networks, and we seek advice on numerous on-line discussion groups. Although in...

  18. La grammaire, tu piges ? niveau 1

    CERN Document Server

    Granger, Colin

    1997-01-01

    This French resource is one of a series of stand-alone photocopiable materials designed to supplement any modern-language course. The activities are suitable for individuals, pairs, groups and whole-class language practice.

  19. La grammaire, tu piges ? niveau 2

    CERN Document Server

    Granger, Colin

    1997-01-01

    This French resource is one of a series of stand-alone photocopiable materials designed to supplement any modern-language course. The activities are suitable for individuals, pairs, groups and whole-class language practice.

  20. La ayahuasca te da tu arte

    Directory of Open Access Journals (Sweden)

    Paolo del Aguila

    2014-09-01

    Full Text Available Para Paolo del Águila, descendiente del pueblo asháninka, la creatividad es un don de las plantas. Durante su primera experiencia visionaria, la ayahuasca personificada en el cuerpo de anciana le entregó unos pinceles y un estilo propio, liberándolo de las disputas y los convencionalismos que había encontrado en la escuela de arte en Pucallpa. Desde entonces, pintura y vida son indisociables y su objetivo como artista es comunicar al público las experiencias espirituales que le acontecieron en un ámbito normalmente invisible que él se esfuerza por visibilizar.

  1. Fuzzy TU games and their classes

    Czech Academy of Sciences Publication Activity Database

    Mareš, Milan

    2001-01-01

    Roč. 7, č. 13 (2001), s. 83-88 ISSN 1212-074X R&D Projects: GA ČR GA402/99/0032 Institutional research plan: AV0Z1075907 Keywords : fuzzy set * coalitional gam * fuzzification of game Subject RIV: BB - Applied Statistics, Operational Research

  2. TU-AB-BRD-01: Process Mapping

    Energy Technology Data Exchange (ETDEWEB)

    Palta, J. [Virginia Commonwealth University (United States)

    2015-06-15

    Current quality assurance and quality management guidelines provided by various professional organizations are prescriptive in nature, focusing principally on performance characteristics of planning and delivery devices. However, published analyses of events in radiation therapy show that most events are often caused by flaws in clinical processes rather than by device failures. This suggests the need for the development of a quality management program that is based on integrated approaches to process and equipment quality assurance. Industrial engineers have developed various risk assessment tools that are used to identify and eliminate potential failures from a system or a process before a failure impacts a customer. These tools include, but are not limited to, process mapping, failure modes and effects analysis, fault tree analysis. Task Group 100 of the American Association of Physicists in Medicine has developed these tools and used them to formulate an example risk-based quality management program for intensity-modulated radiotherapy. This is a prospective risk assessment approach that analyzes potential error pathways inherent in a clinical process and then ranks them according to relative risk, typically before implementation, followed by the design of a new process or modification of the existing process. Appropriate controls are then put in place to ensure that failures are less likely to occur and, if they do, they will more likely be detected before they propagate through the process, compromising treatment outcome and causing harm to the patient. Such a prospective approach forms the basis of the work of Task Group 100 that has recently been approved by the AAPM. This session will be devoted to a discussion of these tools and practical examples of how these tools can be used in a given radiotherapy clinic to develop a risk based quality management program. Learning Objectives: Learn how to design a process map for a radiotherapy process Learn how to perform failure modes and effects analysis analysis for a given process Learn what fault trees are all about Learn how to design a quality management program based upon the information obtained from process mapping, failure modes and effects analysis and fault tree analysis. Dunscombe: Director, TreatSafely, LLC and Center for the Assessment of Radiological Sciences; Consultant to IAEA and Varian Thomadsen: President, Center for the Assessment of Radiological Sciences Palta: Vice President of the Center for the Assessment of Radiological Sciences.

  3. Przeciw Świętu wiosny

    Directory of Open Access Journals (Sweden)

    Richard Taruskin

    2016-10-01

    Full Text Available [Editorial abstract] The paper analyses multifaceted manifestations of resistance to Rite of Spring by Igor Stravinsky. It discusses artistic, cultural, philosophical, and political sources of the resistance.

  4. TU-A-BRB-03: Panel Member

    International Nuclear Information System (INIS)

    Winey, B.

    2016-01-01

    Brain stereotactic radiosurgery (SRS) and spine stereotactic body radiation therapy (SBRT) are commonly treated by a multidisciplinary team of neurosurgeons, radiation oncologists, and medical physicists. However the treatment objectives, constraints, and technical considerations involved can be quite different between the two techniques. In this interactive session an expert panel of speakers will present clinical brain SRS and spine SBRT cases in order to demonstrate real-world considerations for ensuring safe and accurate treatment delivery and to highlight the significant differences in approach for each treatment site. The session will include discussion of topic such as clinical indications, immobilization, target definition, normal tissue tolerance limits, and beam arrangements. Learning Objectives: Understand the differences in indications and dose/fractionation strategies for intracranial SRS and spine SBRT. Describe the different treatment modalities which can be used to deliver intracranial SRS and spine SBRT. Cite the major differences in treatment setup and delivery principles between intracranial and spine treatments. Identify key critical structures and clinical dosimetric tolerance levels for spine SBRT and intracranial SRS. Understand areas of ongoing work to standardize intracranial SRS and spine SBRT procedures. Schlesinger: Research support: Elekta Instruments, AB; D. Schlesinger, Elekta Instruments, AB - research support; B. Winey, No relevant external funding for this subject.

  5. TU-A-BRB-02: Panel Member

    International Nuclear Information System (INIS)

    Ma, L.

    2016-01-01

    Brain stereotactic radiosurgery (SRS) and spine stereotactic body radiation therapy (SBRT) are commonly treated by a multidisciplinary team of neurosurgeons, radiation oncologists, and medical physicists. However the treatment objectives, constraints, and technical considerations involved can be quite different between the two techniques. In this interactive session an expert panel of speakers will present clinical brain SRS and spine SBRT cases in order to demonstrate real-world considerations for ensuring safe and accurate treatment delivery and to highlight the significant differences in approach for each treatment site. The session will include discussion of topic such as clinical indications, immobilization, target definition, normal tissue tolerance limits, and beam arrangements. Learning Objectives: Understand the differences in indications and dose/fractionation strategies for intracranial SRS and spine SBRT. Describe the different treatment modalities which can be used to deliver intracranial SRS and spine SBRT. Cite the major differences in treatment setup and delivery principles between intracranial and spine treatments. Identify key critical structures and clinical dosimetric tolerance levels for spine SBRT and intracranial SRS. Understand areas of ongoing work to standardize intracranial SRS and spine SBRT procedures. Schlesinger: Research support: Elekta Instruments, AB; D. Schlesinger, Elekta Instruments, AB - research support; B. Winey, No relevant external funding for this subject.

  6. TU-A-BRB-01: Panel Member

    International Nuclear Information System (INIS)

    Schlesinger, D.

    2016-01-01

    Brain stereotactic radiosurgery (SRS) and spine stereotactic body radiation therapy (SBRT) are commonly treated by a multidisciplinary team of neurosurgeons, radiation oncologists, and medical physicists. However the treatment objectives, constraints, and technical considerations involved can be quite different between the two techniques. In this interactive session an expert panel of speakers will present clinical brain SRS and spine SBRT cases in order to demonstrate real-world considerations for ensuring safe and accurate treatment delivery and to highlight the significant differences in approach for each treatment site. The session will include discussion of topic such as clinical indications, immobilization, target definition, normal tissue tolerance limits, and beam arrangements. Learning Objectives: Understand the differences in indications and dose/fractionation strategies for intracranial SRS and spine SBRT. Describe the different treatment modalities which can be used to deliver intracranial SRS and spine SBRT. Cite the major differences in treatment setup and delivery principles between intracranial and spine treatments. Identify key critical structures and clinical dosimetric tolerance levels for spine SBRT and intracranial SRS. Understand areas of ongoing work to standardize intracranial SRS and spine SBRT procedures. Schlesinger: Research support: Elekta Instruments, AB; D. Schlesinger, Elekta Instruments, AB - research support; B. Winey, No relevant external funding for this subject.

  7. TU-AB-204-04: Partnerships

    International Nuclear Information System (INIS)

    Ochs, R.

    2016-01-01

    The responsibilities of the Food and Drug Administration (FDA) have increased since the inception of the Food and Drugs Act in 1906. Medical devices first came under comprehensive regulation with the passage of the 1938 Food, Drug, and Cosmetic Act. In 1971 FDA also took on the responsibility for consumer protection against unnecessary exposure to radiation-emitting devices for home and occupational use. However it was not until 1976, under the Medical Device Regulation Act, that the FDA was responsible for the safety and effectiveness of medical devices. This session will be presented by the Division of Radiological Health (DRH) and the Division of Imaging, Diagnostics, and Software Reliability (DIDSR) from the Center for Devices and Radiological Health (CDRH) at the FDA. The symposium will discuss on how we protect and promote public health with a focus on medical physics applications organized into four areas: pre-market device review, post-market surveillance, device compliance, current regulatory research efforts and partnerships with other organizations. The pre-market session will summarize the pathways FDA uses to regulate the investigational use and commercialization of diagnostic imaging and radiation therapy medical devices in the US, highlighting resources available to assist investigators and manufacturers. The post-market session will explain the post-market surveillance and compliance activities FDA performs to monitor the safety and effectiveness of devices on the market. The third session will describe research efforts that support the regulatory mission of the Agency. An overview of our regulatory research portfolio to advance our understanding of medical physics and imaging technologies and approaches to their evaluation will be discussed. Lastly, mechanisms that FDA uses to seek public input and promote collaborations with professional, government, and international organizations, such as AAPM, International Electrotechnical Commission (IEC), Image Gently, and the Quantitative Imaging Biomarkers Alliance (QIBA) among others, to fulfill FDA’s mission will be discussed. Learning Objectives: Understand FDA’s pre-market and post-market review processes for medical devices Understand FDA’s current regulatory research activities in the areas of medical physics and imaging products Understand how being involved with AAPM and other organizations can also help to promote innovative, safe and effective medical devices J. Delfino, nothing to disclose

  8. Associated consistency and values for TU games

    NARCIS (Netherlands)

    Driessen, Theo

    In the framework of the solution theory for cooperative transferable utility games, Hamiache axiomatized the well-known Shapley value as the unique one-point solution verifying the inessential game property, continuity, and associated consistency. The purpose of this paper is to extend Hamiache’s

  9. Soutien du programme de savoir, d'innovation et de développement ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet a pour objectif de renforcer les capacités de FORO de réaliser des recherches, de susciter des débats et d'exercer une influence en ce qui concerne les politiques de STI et d'autres politiques sociales et économiques propices au développement inclusif et durable au Pérou. Il soutiendra une série d'études portant ...

  10. Liens entre le savoir et l'innovation dans les services de gestion des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Extrants. Documents. Linking knowledge to innovation in government services: the case of solid waste services in local government in Sri Lanka (K2I Project). Téléchargez le PDF. Rapports ... GrowInclusive : la plateforme tant attendue est en construction. Le CRDI, en partenariat avec le Forum économique mondial, ...

  11. L'algerie, du transfert de technologie a l'economie du savoir et de l ...

    African Journals Online (AJOL)

    Les nouvelles théories de la croissance endogène consa-crent la recherche et le capital humain comme facteurs centraux de la croissance, Plus tard la vision évolutionniste déclasse le marché comme seul moteur de changement technologique et met l'innovation par le biais de l'approche systémique au coeur du ...

  12. Apprendre, un moment de vie ? Savoir, expérience et rapport au vivant

    Directory of Open Access Journals (Sweden)

    Noack Julie

    2015-01-01

    Full Text Available L’objectif de cette communication est de comparer sur le plan pédagogique deux conceptions du rapport entre science et vivant, diamétralement opposées sur le plan épistémologique. En se basant sur un livre [1], une conférence [2] et un entretien [3], on analysera l’expérience de pensée par laquelle le biologiste et épistémologue Jean-Jacques Kupiec fait se sentir vivants les apprenants afin de mieux les conscientiser aux réquisits de la démarche scientifique. On comparera ensuite les motivations de Kupiec avec les idées pédagogiques du philosophe-médecin Georges Canguilhem (1904–1995 afin d’essayer de comprendre pourquoi l’un et l’autre jugent pertinent de faire remarquer à l’apprenant qu’il est actuellement en vie. Car, malgré des conceptions du vivant diamétralement opposées, Canguilhem et Kupiec se rejoignent sur l’idée que l’expérience vitale joue un rôle crucial – que ce soit en positif ou en négatif, comme un obstacle épistémologique ou comme un levier heuristique – dans l’apprentissage et la pratique de la biologie ou de la médecine. Prendre en charge cette expérience constitue peut-être une ressource face au double défi (scientifique et éthico-politique qui échoit à l’éducation aux sciences du vivant.

  13. Un nouveau monde du savoir : Les universités canadiennes et la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ou simplement d'un message de marketing qui vise à positionner l'université de façon à lui permettre de contrer les compressions budgétaires par la vente de ... Le nouveau site Web et la nouvelle bibliothèque de ressources aideront à améliorer les systèmes d'information et d'enregistrement des faits d'état civil dans les ...

  14. Rapport au savoir et psychose ordinaire: considérations cliniques

    Directory of Open Access Journals (Sweden)

    Jean-Luc Gaspard

    2010-01-01

    Full Text Available A introdução do sintagma "psicose ordinária" por J.-A. Miller permitiu enfatizar a atualidade de uma nova clínica dita "continuista", não relegando mais a psicose somente às formas fixadas pelo discurso psiquiátrico. No tempo em que o Outro não existe, o atendimento desses sujeitos permite levar em conta as modalidades de bricolagem que fazem com que as dimensões RSI se mantenham juntas. Este artigo pretende iniciar uma reflexão em torno das ligações entre função paterna e relação ao saber. Para tanto, parte da distinção entre neurose e psicose a partir da relação do sujeito com o saber e discute o encontro do sujeito com um analista e o comparecimento de um saber já constituído, um saber total, de onde o psicótico retira sua certeza. Ao mesmo tempo, distingue na psicose o processo de pensamento e a relação com o corpo. A partir de dois casos clínicos, aborda a vergonha e a descrença e enfatiza as semelhanças e diferenças entre neurose e "psicose ordinária" na relação com o saber. Conclui com considerações sobre a posição do analista, de destinatário de signos sem sentido, com vistas a auxiliar uma abertura ao laço social para o sujeito da psicose.

  15. Technologies omniprésentes et accès au savoir (A2K) | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'omniprésence des technologies de la communication en réseau transforme les modes d'accès à l'information partout dans le monde. Le prix des téléphones mobiles et ... Six équipes de chercheurs de classe mondiale étudieront comment surmonter la résistance au traitement des cancers les plus mortels. Les équipes de ...

  16. Droits d'auteur et accès au savoir en Afrique | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Legislative review : review of IPR Act and regulations : Intellectual Property Rights from Publically Financed Research and Development Act, Act No. 51 of 2008, Republic of South Africa. Téléchargez le PDF. Articles de revue. Copyright and education : lessons on African copyright and access to knowledge. Téléchargez le ...

  17. Savoir, innovation, solutions: septième assemblée publique ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    18 mars 2016 ... En partenariat avec trois organismes canadiens, le CRDI appuie les essais cliniques d'un vaccin prometteur contre la maladie à virus Ebola en Guinée, mis au point au Canada. Le CRDI, qui pilote les efforts du Canada sur ce vaccin, a partagé avec d'autres ministères un prix d'excellence de la fonction ...

  18. Savoir-faire des populations locales des taxons du Jardin Botanique ...

    African Journals Online (AJOL)

    Objectif : En vu de connaître l'usage des espèces végétales du Jardin Botanique de Bingerville par les populations locales, diverses activités de recherche ont été réalisées. Méthodologies et résultats : Le recensement de la flore a été effectué et a permis d'enregistrer 419 taxons. A l'issue d'une enquête ethnobotanique ...

  19. l'algerie, du transfert de technologie a l'economie du savoir et de l ...

    African Journals Online (AJOL)

    Abdelkader DJEFLAT

    s'occuper de la recherche appliquée dans le domaine des énergies re- ... recherche sous la forme de projets et de programmes distincts des tra- ..... Les cahiers du CREAD n°100-2012. 85. Maroc également11. L'inadéquation de la formation et les problèmes de niveau de qualifications risquent de poser à terme un sérieux ...

  20. Savoir lire les centres historiques comme clé pour construire la ville de demain

    Directory of Open Access Journals (Sweden)

    Alexis Sierra

    2010-05-01

    Full Text Available Yves Dauge est sénateur d’Indre et Loire (membre de la commission de la culture, de l'éducation et de la communication, membre du groupe d'études sur le patrimoine architectural. Inspecteur général de l’équipement, ancien maire de Chinon, il a été délégué interministériel à la ville et au développement social urbain de 1988 à 1991. Il a conduit la délégation française au Vème Forum Urbain Mondial à Rio. Il anime avec les services du Ministère des Affaires Etrangères et Européennes, le nouvea...

  1. Savoir-faire des populations locales des taxons du Jardin Botanique ...

    African Journals Online (AJOL)

    SARAH

    2 sept. 2013 ... pour guérir l'asthme : la poudre obtenue par pulvérisation des feuilles de Adansonia digitata est consommée en sauce ; le décocté de feuilles de. Baphia nitida (okoué) est consommé en boisson ; l'infusion des feuilles de Boerhavia diffusa donne une solution prise en boisson ; le décocté de pétioles de.

  2. Knowing anything on wind energy channel; Tout savoir sur la filiere eolienne

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1997-12-31

    This extra booklet gives a glimpse on regional development of wind power generation. Dispersed generators on the shore deliver power for two types of uses. Either a single generator produces power dedicated to an industrial use, or computer controlled sets of a few generators ( less than 10 ) are connected to the general power network as small production units. Market trends for industrial builders of wind generators are sketched out. (D.L.)

  3. Intégration du savoir autochtone à la gestion des risques ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Driving vaccine innovations to improve lives and livelihoods. Five world-class research teams are working to develop vaccines for neglected livestock diseases in the Global South. View moreDriving vaccine innovations to improve lives and livelihoods ...

  4. Exploitation du savoir autochtone afin de créer des emplois pour les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Pour les habitants qui dépendent des terres, ces transformations ont eu de graves incidences sur le plan social et écologique : - un déplacement ... Il existe un besoin reconnu en institutions intermédiaires, comme les médias, les partis politiques et les syndicats, pour aider les citoyens à exercer leurs droits. Les techniciens ...

  5. Le savoir offre aux jeunes des milieux urbains d'autres possibilités ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 août 2016 ... Les chercheurs du CRDI en Côte d'Ivoire recommandent que les responsables des politiques s'attaquent d'urgence au chômage chez les jeunes. ... Kuluna à Kinshasa, se considèrent comme « socialement morts » et se tournent vers la vie de gang pour avoir un sentiment d'appartenance à la collectivité.

  6. Climate change: the knowledge and the possible; Changement climatique: les savoirs et les possibles

    Energy Technology Data Exchange (ETDEWEB)

    Le Treut, H. [Institut Pierre Simon Laplace, Lab. de Meteorologie Dynamique, 94 - Ivry sur Seine (France); Huet, S. [Journaliste a Liberation, Domaine de l' Information Scientifique, 75 - Paris (France); Chappellaz, J. [Centre National de la Recherche Scientifique (CNRS), Lab. de Glaciologie et Geophysique de l' Environnement de Grenoble, 38 - Grenoble (France); Godard, O. [Centre National de la Recherche Scientifique (CNRS), Dept. Humanites et Sciences Sociales, Ecole Polytechnique, 75 - Paris (France)

    2010-07-01

    Ultimatum, justice, crisis, green development, skepticism, controversy.. climate change is making noise in the beginning of this- 21 century and is going to make much more. In order to act with full knowledge of the facts, it is recommended to get the information from the right source and to make a precise status of the available knowledge. Then, this knowledge must be analyzed to understand how it has been obtained, discussed, validated, spread and sometimes distorted. This is what the authors of this book are applying themselves to do: two climatologists, one economist and one journalist are joining their skills and give us the keys that allow us to decode the paradoxes and challenges of the climate question. They provide us with intellectual arms to fight against the insincere skepticism and to discuss about the rational skepticism. (J.S.)

  7. INVESTIR DANS LE SAVOIR : le soutien que le CRDI consent à des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    5 nov. 2010 ... ... 40 ans, le Cenre de recherches pour le développement international (CRDI), en plus d'appuyer des travaux de recherche dans l'ensemble des pays en développement, encourage des générations successives de jeunes chercheurs par l'entremise de son Programme de formation et de bourses (PFB).

  8. Un nouveau monde du savoir : Les universités canadiennes et la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ou simplement d'un message de marketing qui vise à positionner l'université de façon à lui permettre de contrer les compressions budgétaires par la vente de services d'éducation ? Dans Un ... Board of Governors. IDRC invests in knowledge, innovation, and solutions to improve the lives of people in the developing world.

  9. Fait saillant : Du savoir à l'action : Améliorer la vie des femmes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Université McGill, et Stella Muthuri, boursière de recherches postdoctorales au African Population Health and Research Council au Kenya, ont présenté la situation actuelle en matière de garde d'enfants dans le bidonville de ...

  10. Combler l'écart entre la recherche et le savoir | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    extérieur en mettant à profit les compétences, les connaissances et l'imagination d'un ensemble de personnes. Selon les professeurs Chevalier et Buckles, il est plus urgent que jamais de faire participer tous les êtres ...

  11. Savoir combler un déficit en eau | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 déc. 2010 ... Tête-à-tête avec David Brooks sur la rareté de l'eau et la gestion locale · Water Management in Africa and the Middle East: Challenges and Opportunities Une crise de l'eau est imminente en Afrique et au Moyen-Orient, où le volume annuel renouvelable d'eau douce par personne a diminué de moitié ...

  12. The Basoche in the late Middle Ages: a school of technical savoir-faire

    NARCIS (Netherlands)

    Bouhaïk-Gironès, M.; van Dixhoorn, A.; Speakman Sutch, S.

    2008-01-01

    The Basoche of Paris was the professional community of law clerks attached to the Parlement of Paris, created in the fourteenth century. The law clerks had their own specific communal, professional and cultural practices, among which literature and theatre took on a major role. The Basoche

  13. Savoir combler un déficit en eau | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 déc. 2010 ... C'est ainsi que les Jordaniens examinent toute une gamme de mesures, dont certaines sont déjà en chantier. Cela va de changements dans les habitudes de consommation jusqu'à de grands travaux ambitieux. Une initiative modeste, par exemple, est la pratique devenue courante de compenser la rareté ...

  14. Exploitation du savoir autochtone afin de créer des emplois pour les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La Commission des Nations unies pour la démarginalisation estime que quatre milliards de personnes ne peuvent pas exercer leurs droits juridiques à cause des coûts, du dysfonctionnement, de la corruption ou de l'abus de pouvoir. Il existe un besoin reconnu en institutions intermédiaires, comme les médias, les partis ...

  15. D'éminents spécialistes mettent leur savoir-faire en commun | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 oct. 2010 ... Les bienfaits d'Internet sont en effet limités en Chine, car 1,3 milliard de personnes ne lisent pas l'anglais, et seulement 163 millions utilisent un ordinateur. Ming Li explique que la solution consiste à accroître les fonctions des moteurs de recherche. Les chercheurs s'appliquent donc à mettre au point un ...

  16. Technologies omniprésentes et accès au savoir (A2K) | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    De fait, ces appareils viennent remplir les promesses d'initiatives comme " Un ordinateur portable par enfant " (OLPC), qui n'ont jamais vraiment livré les résultats attendus. En Chine, les fabricants de matériel informatique inventent des appareils technologiques ou en remanient pour en créer de nouveaux, dont le statut ...

  17. Déconstruire les savoirs sur l’Afrique et les relire en mode hypertexte.

    Directory of Open Access Journals (Sweden)

    Sylvain Guyot

    2005-06-01

    Full Text Available L’Afrique est le dernier ouvrage paru (janvier 2005 à destination des candidats préparant les concours de l’enseignement secondaire (Capes et Agrégation en histoire et géographie. Sous la direction d’Anne Volvey, ce livre a été conçu et écrit collectivement par un groupe de jeunes chercheurs et enseignants-chercheurs (cinq géographes et une historienne composé en majorité de spécialistes de contrées africaines. Si j’encourage vivement tous les candidats à le consulter, ...

  18. La voie vers l'harmonie : savoir partager les ressources | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    26 janv. 2011 ... Au Pérou, institutions publiques, entreprises privées, porteurs, touristes et même l'UNESCO forment un tissu complexe d'intérêts divers et se disputent sur la façon de gérer le site fragile qu'est la citadelle du Machu Picchu. À Cochabamba, en Bolivie, la gestion de l'approvisionnement en eau a fait l'objet ...

  19. La fabrique du savoir Essai sur les carnets de voyage d'Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Marie-Noëlle Bourguet

    2006-10-01

    Full Text Available Article in French, Abstract in English.Whilst the notebook belongs to the imagery of the enlightened scientist's persona (an auxiliary tool kept by his side to be hastily scribbled with data, when at the bench or in the field, it has been given little attention by historians of science, who are used to consider its manuscript pages as a documentary resource to complement the printed text, but rarely take the notebook as a material and cultural object by itself, the history and epistemology of which is to be explored. Only recently have new trends in the historiography, by historians of printed books and reading practices, and by social and cultural historians of knowledge, called for a fresh look and opened the way for new approaches. Taking Alexander von Humboldt as a paramount example, who expressly devoted his life to "observing and recording" the world, pen in hand, this paper explores the note-taking practices at work in his travel diaries and notebooks from the perspective of the history of scientific observation and cognitive practices. Four themes are successively considered : the question of method and apprenticeship ; the timing of note-taking practices ; the nature and status of the data jotted down on the page ; finally, their uses in the production of scientific knowledge. In the back and forth movement between the observation of the world and the writing of science, the notebook stood as a crucial intellectual step and cognitive tool.

  20. Des mots pour voir et savoir - Le dictionnaire de voyage revisité

    DEFF Research Database (Denmark)

    Leroyer, Patrick; Rasmussen, Kirsten Wølch

    2017-01-01

    According to Hans Christian Andersen, to travel is to live. When crossing borders and cultures, travelers of modern times, tourists, need fast and easy access to relevant intercultural information in order to live out their travel dreams and augment their reality. They need words to guide them...

  1. Intégration du savoir autochtone à la gestion des risques ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les exploitants agricoles africains se fient depuis toujours aux connaissances autochtones pour comprendre le climat, prévoir les conditions météorologiques et prendre des décisions à propos de leurs cultures et des cycles d'irrigation. Toutefois, la variabilité accrue associée aux changements climatiques a miné leur ...

  2. LES APPROCHES PLURIELLES DANS LE MODELE CARAP: SAVOIRS ACQUIS PAR L'INTERCOMPREHENSION

    Directory of Open Access Journals (Sweden)

    Constantin Felicia

    2012-07-01

    Full Text Available Custom sets that teaching foreign languages refers to teaching and learning a language taken in isolation, within an essentially monolingual framework. Academic orthodoxy Chardenet (2007 refers to training the teacher in one foreign language only, following the unnatural preoccupation for the completion of knowledge and skills in this language. The dynamics of the societies forces towards the transition from monolingualism to multilingualism, by introducing the pluralistic like teaching devices. Defined as "teaching approaches that put into practice the teaching-learning activities while involving more (= more than one linguistic and cultural variety," pluralistic approaches are designed as opposed to traditional teaching approaches, the aim of which is a particular language or culture in isolation (Candelier, 2007: 7. Intercomprehension is, along with the intercultural approach, the integrated teaching of foreign languages and awakening to languages, a pluralistic approach that allows the development of diverse and unthinkable emotional and practical knowledge and skills, inventoried in a Framework of reference for pluralistic approaches to languages and cultures (CARAP. Considered from different perspectives - as a method, strategy, training device or educational purpose - intercomprehension is mainly a general competence of the multilingual individual. A doctoral program attended at the University of Reims, France, as part of a team coordinated by professors J.E. Tyvaert and E. Castagne, has allowed us to experiment intercomprehension with a public trained for skills training for acquiring the perception and understanding of foreign languages not known a priori. According to Jamet (2010, it is a metalinguistic cognitive type activity (the awareness of areas of formal transparency and of significance, meta-pragmatic (the use of knowledge acquired in the native language to decide the needs triggered in a certain situation and meta-cultural (by means of the encyclopaedic knowledge of the world, activity practiced by inferential type strategies. The regular observation of ICE type training sessions has led us to a reflection applied to non-philological learning environment. We consider that organizing a module of initiation in French for beginner economic students, a course relying on intercomprehension principles, would be an excellent introduction to multilingualism. In this paper we will tackle the knowledge that, according to CARAP, seems attainable by means of this alternative method of teaching - learning a language, in the light, even if only virtual at the moment, of the introduction of French in the curriculum by specific means of intercomprehension. Established as prolegomena to the traditional study, an introductory course of intercomprehension of French would be able to provide students with quicker global linguistic knowledge otherwise acquired in a longer period of time, with more effort and without guaranteed results.

  3. Conjunto de actividades para la estimulación del desarrollo físico en los niños de 4-5 años atendidos en el programa “educa a tu hijo” en la circunscripción # 185 del consejo popular 10 de octubre del municipio la Pinar del Río

    Directory of Open Access Journals (Sweden)

    Adelina Saldañas Carmona

    2009-12-01

    Full Text Available La necesidad de preparar a los promotoras y ejecutoras para orientar a la familia en la estimulación temprana en los niños con el propósito de concebir un proceso educativo y desarrollador en las condiciones de vida y educación me motivaron a proponer actividades físico para niños de 4-5 años, atendidas por el Programa “Educa a tu Hijo”. Como punto de partida se realizó una valoración de cómo se desarrolla la atención a los niños y niñas de estas edades atendidas por el Programa “Educa a tu Hijo” con énfasis en la estimulación al desarrollo físico de los mismos, realizando un diagnostico a la situación actual de esta actividad en el consejo popular, entrevista- encuesta a los promotores , ejecutoras,a los líderes comunitarios así como organizaciones tales como el INDER municipal , Ministerio Educación municipal pudiéndose constatar que existe un bajo nivel de participantes, poca sistematización , pobre desarrollo de esta actividad lo que sin duda redunda en detrimento del desarrollo y estimulación del desarrollo físico de estos niños Por lo anteriormente expuesto se proponen actividades físicas, asequibles con ejemplos precisos y variados en aras de estimular el desarrollo en los niños de 4-5 años atendidos en este programa educativo. Como novedad se ha puesto al alcance de ejecutoras y promotores un soporte digital DVD que permite brindar mejor orientación a las ejecutaras y promotores en la organización de estas actividades , facilitando la estimulación y desarrollo físico e intelectual, de manera oportuna consciente y organizada favoreciendo la preparación del niño para su ingreso en la escuela.

  4. Propuesta de Actividades Recreativas Físicas para elevar la participación de Niños y padres del Programa Educa a tu Hijo de 1 A 4 años de vida en el Consejo Popular Hermanos Barcon del Municipio Pinar del Rio

    Directory of Open Access Journals (Sweden)

    Ismael Becerra Vento

    2009-12-01

    Full Text Available En Cuba todos los niños de dos a cinco años de edad que no asisten a los círculos infantiles son atendidos en el programa educa a tu hijo por la vía no institucional. Nuestros profesores deben preparar las familias para que a partir de su experiencia estimulen el desarrollo integral de sus hijos. Uno de los problemas que enfrentan es elevar la participación de niños y padres para ejecutar ejercicios que manifiesten la buena postura, capacidades coordinativas y juegos. De esta forma el padre puede favorecer en el hogar y durante sus paseos a la comunicación afectiva, la alegría y disposición de su hijo. Varias tesis en esta materia dan paso a nuestra teoría. No obstante, la preoucapacion que siempre asaltaba mi mente era la propuesta de ejercicios recreativos físicos capaces de mantener el interés y motivación del niño y su familia. Fue así como decidimos revisar las bibliografías existentes, consultar a muchos especialistas en la temática, realizar encuestas y entrevistas a padres o tutores. El curso de la investigación nos aportaba muchas ideas para ampliar la propuesta. Así se multiplicaron las actividades con estos niños en la comunidad elevando la cultura de cada familia. Ya no solo era la preocupación de los niños por participar sino de padres y abuelos que venían a observar las actividades para ponerlas en práctica. Esta propuesta de actividades recreativas físicas sin dudas podrá desarrollarse en todos los consejos populares de nuestro país y tendrá el apoyo del grupo coordinador del programa educa a tu hijo.

  5. Vairogdziedzera kompensējamo hormonālo preparātu aprites īpatnības Rīgā laika posmā no 2013.gada janvāra līdz 2013.gada decembrim

    OpenAIRE

    Loča, Agita

    2014-01-01

    Vairogdziedzeris regulē audu attīstību, stimulē vielmaiņu un ietekmē nervu sistēmas darbību, kā arī visa organisma augšanu un attīstību. Ar katru gadu pieaug pacientu skaits, kam jālieto vairogdziedzera hormonālie preparāti. Šādu situāciju veicina ekoloģiskās situācijas pasliktināšanās, produkti, kuri satur kancerogēnus, kā arī joda trūkums ūdenī un pārtikā, līdz ar to, arī mūsu organismā. Maģistra darbs izstrādāts ar mērķi – noskaidrot vairogdziedzera hormonālo preparātu aprites īpatnības...

  6. Výchova ke zdraví v učebnicích 1. stupně ZŠ: výsledky analýzy didaktického aparátu učebnic prvouky/přírodovědy/Health education in primary school textbooks – results of a content analysis

    Directory of Open Access Journals (Sweden)

    Markéta Hrozová

    2015-02-01

    Full Text Available Cílem empirické studie je prezentace výsledků obsahové analýzy didaktického aparátu učebnic a cvičebnic školního vzdělávacího předmětu prvouka/přírodověda určených pro žáky 1. stupně základních škol z hlediska jejich zaměření na výchovu ke zdraví. V první části studie prezentujeme teoretický základ našeho výzkumu, který spočíval ve vymezení analytických kategorií vyplývajících z holistického pojetí zdraví. V druhé části představujeme cíle a metody výzkumu, výzkumný vzorek sestávající z pěti současných ucelených učebnicových řad učebnic prvouky/ přírodovědy (38 učebnic/cvičebnic; 3136 zkoumaných jednotek, tedy otázek, námětů a úkolů zařazených do učebnic platných pro 1. stupeň základního vzdělávání. Třetí část je věnována výsledkům analýzy, která poukázala na významné rozdíly v prezentaci učiva v oblasti výchova ke zdraví. Z výsledků vyplývá nereflektování holistického pojetí zdraví v jeho plném rozsahu, majoritní zastoupení biologického kontextu zdraví ve zkoumaných učebnicích. Holistické pojetí zdraví nejvíce reflektují učebnice druhých ročníků. Dále poukazujeme na významné rozdíly ve strukturaci učiva v rámci jednotlivých učebnicových řad (absence tematiky zdraví ve většině zkoumaných učebnic 4. ročníků a nestabilitu v distribuci tematických celků zkoumaného vzorku učebnic. V závěru studie (čtvrtá a pátá část jsou diskutovány výsledky, možnosti a limity studie a představujeme eventuality navazujícího výzkumného šetření.

  7. Intra-specific brood parasitism revealed by DNA micro-satellite analyses in a sub-oscine bird, the vermilion flycatcher Parasitismo intraespecífico revelado mediante análisis de microsatélites de ADN en un ave suboscina, el cardenalito o saca tu real

    Directory of Open Access Journals (Sweden)

    ALEJANDRO A RÍOS-CHELÉN

    2008-03-01

    ón extrapareja. En este estudio nos preguntamos si ocurre o no la reproducción extrapareja en el cardenalito o saca tu real (Pyrocephalus rubinus, un suboscino sexualmente dimórfico y socialmente monógamo. Reportamos casos de paternidad extrapareja, maternidad extrapareja y parasitismo intraespecífico, y discutimos nuestros resultados bajo la luz de otros estudios en paserinos

  8. „My tu nie mówimy, ino godumy i jesteśmy z tego dumni”. O tym, dlaczego gwary wielkopolskie przetrwały (na przykładzie języka mieszkańców wsi powiatu międzychodzkiego

    Directory of Open Access Journals (Sweden)

    Bartosz Cemborowski

    2015-12-01

    Full Text Available On why have the dialects of the Province of Greater Poland survived (an example, the language of Międzychodzki district inhabitants The aim of this article is to respond to the question: Why have the dialects of the Province of Greater Poland survived while the dialects from other parts of Poland are in decline? The analytical material relates to the statements of the users of this dialect who live in the western parts of Greater Poland (Międzychodzki district. It was collected during fieldwork in the villages of the Międzychodzki district between 2012 and 2015. The research methodology was based on autobiographical interviews, questionnaires and participant observations. Three important factors which contributed to the survival of the dialects of Greater Poland are: the history of this region, the identity of its people and the fashion for dialect use among the younger generation of Greater Poland’s inhabitants.   „My tu nie mówimy, ino godumy i jesteśmy z tego dumni”. O tym, dlaczego gwary wielkopolskie przetrwały (na przykładzie języka mieszkańców wsi powiatu międzychodzkiego Celem artykułu jest odpowiedź na pytanie, dlaczego gwary wielkopolskie przetrwały, podczas gdy w innych regionach Polski zauważalna jest tendencja do ich zaniku. Materiałem wykorzystanym w analizie są wypowiedzi mieszkańców wsi powiatu międzychodzkiego, którzy posługują się gwarą. Materiał został zebrany podczas badań terenowych w latach 2012–2015 za pomocą takich metod, jak wywiad autobiograficzny, ankiety i obserwacja uczestnicząca. Trzema istotnymi czynnikami, które wpłynęły na to, że gwary przetrwały w języku respondentów, są: historia, identyfikacja i narastająca wśród młodego pokolenia moda na mówienie gwarą.

  9. Commerce, sexospécificités et équité en Amérique latine : le savoir ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    économique en se retirant des services publics, y compris des services essentiels à la reproduction humaine tels que le soin des jeunes, des personnes âgées et des malades. Puisque les femmes jouent déjà un rôle disproportionné dans la ...

  10. Intégration des principes de l'accès au savoir (A2K) aux Principes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les Principes directeurs des Nations Unies pour la protection du consommateur ont été adoptés en 1985 afin de formuler un ensemble de normes représentant les pratiques exemplaires en matière de protection du consommateur, en particulier à l'intention des pays en développement. Les Principes directeurs ...

  11. A savoir against barbary: begginings of the popularization of science in the platino space of Uruguay and Brasil

    OpenAIRE

    Silveira, Ada Cristina Machado de; Gripp, Phillip Días

    2015-01-01

    O artigo estrutura elementos históricos no aparecimento de publicações dedicado à cultura científica no Uruguai e na região da Campanha no Estado brasileiro de Rio Grande faça Sul e é interrogado sobre os vínculos existentes naquele espaço platino e que favoreceram o surgimento de duas publicações especializadas analisadas em sua vontade de saber e de poder. Eles se salientam aspectos da revista uruguaia La Propaganda Rural e as publicações criadas por uma associação de produtores sul-brasile...

  12. Réseau d'accès au savoir visant à favoriser l'interconnectivité en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Outputs. Reports. Learning from experience : a manual for organising, analysing and documenting field based information [Arabic language]. Download PDF. Training materials. Some methodologies of agricultural knowledge management for Arab users [Arabic language]. Download PDF ...

  13. « J'aurais préféré ne pas le savoir » : pourquoi les femmes au ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 août 2017 ... Tout au long de mon enfance et de ma jeunesse, le VIH était la crainte à avoir, synonyme d'une condamnation à mort. Malheureusement, malgré les défis et les préjugés qui demeurent, le Swaziland a fait des progrès importants. Le dépistage du VIH et les programmes de counseling sont largement ...

  14. L'individu au coeur des systèmes de santé : savoir et faire | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    4 déc. 2014 ... Increasing immunization, reducing child mortality in Haiti. Results from the Canadian International Immunization Initiative for Haiti. View moreIncreasing immunization, reducing child mortality in Haiti ...

  15. Société du savoir arabe - qui représente le monde arabe en ligne ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Internet est souvent perçu comme un outil habilitant et égalisateur, car il offre aux citoyens un moyen de prendre part aux discussions touchant leur région et les ... an enabler and an equalizer, because it allows citizens a means to discuss their regions and businesses, to voice their concerns and to connect to the people.

  16. Réseau d'accès au savoir visant à favoriser l'interconnectivité en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Report on expert systems developed for onion, barley pomegranate, and tomato in the period from Jan. 1 to Feb. 28, 2013. Download PDF. Reports. Rapport technique final (14 mai 2012 au 30 septembre 2013) / Projet de recherche «Le système d'innovation technique dans la filière maraîchage sous serre à Biskra ...

  17. Réseau d'accès au savoir visant à favoriser l'interconnectivité en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Élaboration et essai pilote de modèles d'affaires pour obtenir des résultats à vaste échelle pour la transformation mécanisée des plantes fourragères. On retrouve en Afrique du Nord des écosystèmes marginaux, ainsi qu'une grande population rurale qui dépend sur des systèmes de cultures irriguées pour leur subsistance.

  18. Accès au savoir en Afrique australe : le libre accès à la recherche à l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Driving vaccine innovations to improve lives and livelihoods. Five world-class research teams are working to develop vaccines for neglected livestock diseases in the Global South. View moreDriving vaccine innovations to improve lives and livelihoods ...

  19. "Communicative Criticality" and "Savoir Se Reconnaître": Emerging New Competencies of Criticality and Intercultural Communicative Competence

    Science.gov (United States)

    Parks, Elinor

    2018-01-01

    This study reports on the findings of a PhD study investigating the implications of the division between language and content in Modern Language degrees on students' development of intercultural competence and criticality across four universities, two in the US and two in the UK. It draws upon the theoretical frameworks of Intercultural…

  20. Réseau d'accès au savoir visant à favoriser l'interconnectivité en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2013-01-25

    Hosting the Regional Knowledge Management and Knowledge Sharing Network / ESDU - KariaNet Project : final report. Download PDF. Reports. Establishment of national networks in Sudan, Morocco and Algeria : final technical report (January 25, 2013 - September 30, 2013). Download PDF. Reports. Innovation contest ...

  1. Réseau sur l'économie du savoir dans les Caraïbes | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les deux projets visent à stimuler la croissance économique en misant davantage sur le capital social, les ressources technologiques, les innovations ... Le projet comprendra en outre de la formation sur le recours à la cartographie des incidences aux fins de l'évaluation d'impact et appuiera la mise sur pied d'un institut ...

  2. Savoir émergent - suivi de la progression vers la société de l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Journal supplement features 10 years of West African health systems research. In the wake of the devastating Ebola virus outbreak in 2014, increased attention has been paid to West Africa's poorly functioning health systems. View moreJournal supplement features 10 years of West African health systems research ...

  3. Intégration des principes de l'accès au savoir (A2K) aux Principes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les Principes directeurs s'appliquent à huit domaines touchant la protection du consommateur, ou droits : le droit à la satisfaction des besoins fondamentaux, à la sécurité, au choix, à l'information, à des programmes d'éducation, à des voies de recours, à la représentation et à un environnement sain. Bien qu'ils n'aient pas ...

  4. Guide documentaire pour en savoir plus sur l'informatique (A Documentary Guide to Further Knowledge of Computer Science).

    Science.gov (United States)

    Achard-Bayle, Guy

    1985-01-01

    Presents a listing of textbooks, computer program guides, articles, opinion papers, histories, reference works, databases, reviews, bibliographies, organizations, and other information sources concerning computer applications. (MSE)

  5. Les sociétés du savoir ... En bref : La technologie de l'information au ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    information et des communications (TIC) sont au cœur des transformations que connaissent depuis quelque temps les Sociétés du monde entier. Plus particulièrement, les pays en développement sont encouragés à investir dans une infrastructure ...

  6. Société du savoir arabe - qui représente le monde arabe en ligne ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ils s'attacheront à déterminer si, en comparaison d'autres régions du monde, le nombre d'articles sur la région est proportionnellement inférieur, si les auteurs de la région sont sous-représentés, et si la structure centralisée de Wikipédia tend à défavoriser les nouveaux contributeurs de la région. Enfin, ils chercheront à ...

  7. Savoir émergent - suivi de la progression vers la société de l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'indice du fossé numérique (DDI) d'Orbicom est un outil statistique rigoureux permettant l'analyse comparative de l'accès aux technologies de l'information et de la communication (TIC) et de leur utilisation, ainsi que le suivi de la progression vers la société de l'information au fil du temps. Cet indice a été mis à jour et ...

  8. L'accès au savoir en Afrique : le rôle du droit d'auteur

    International Development Research Centre (IDRC) Digital Library (Canada)

    Il existe en outre très peu de témoignages démontrant le véritable impact de certains droits d'auteur en particulier, ni d'ailleurs d'autres lois ou politiques de ...... Le mouvement en faveur de la protection du droit d'auteur est soutenu par de grandes entreprises des secteurs de l'industrie cinématographique et musicale ...

  9. Effet de serre : les lacunes du savoir et de la perceptionGreenhouse effect: gaps of knowledge and perception

    Science.gov (United States)

    Lorius, Claude

    2003-06-01

    The anthropogenic emissions of greenhouse gases should result in a marked warming of the Planet. Although quantitatively uncertain, this message is well apprehended by the society. Development of more investigations upon future climate and sources of energy should help to limit the extensiveness of this risk. To cite this article: C. Lorius, C. R. Geoscience 335 (2003).

  10. Si tu devais me dessiner l'Univers

    CERN Document Server

    Saison-Marsollier, Sandrine; Pralavorio, Corinne; Spiro, Michel; Goldberg, Marc

    2015-01-01

    Le CERN a lancé en 2014 un concours de dessins dans les classes de primaire des villes des environs : les enfants étaient invités à s’interroger sur l’Univers, la matière et le métier de chercheur. Le succès de l’opération a été tel qu’il a été décidé d’en faire un livre que l’enseignant pourra parcourir en classe avec ses élèves, discuter avec eux des questions et découvrir ensemble les réponses. Le livre est en effet construit ainsi : sur une double page la question que s’est posée l’enfant et le dessin l’illustrant trouvent leur réponse sur la page d’en face, via un court texte écrit par le chercheur référent (Michel Spiro), qu’accompagne une citation tirée du domaine culturel, destinée à montrer les passerelles entre science, littérature et philosophie. Exemples de questions : Qu’y avait-il avant le Big Bang ? Les chercheurs sont-ils des personnes comme les autres ? Pourquoi les lois de la physique ne changent-elles pas ? Peut-on attraper les particules ?...

  11. TU-A-210-00: HIFU Therapies - A Primer

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    High-intensity focused ultrasound (HIFU) has developed rapidly in recent years and is used frequently for clinical treatments in Asia and Europe with increasing clinical use and clinical trial activity in the US, making it an important medical technology with which the medical physics community must become familiar. Akin to medical devices that deliver treatments using ionizing radiation, HIFU relies on emitter geometry to non-invasively form a tight focus that can be used to affect diseased tissue while leaving healthy tissue intact. HIFU is unique in that it does not involve the use of ionizing radiation, it causes thermal necrosis in 100% of the treated tissue volume, and it has an immediate treatment effect. However, because it is an application of ultrasound energy, HIFU interacts strongly with tissue interfaces, which makes treatment planning challenging. In order to appreciate the advantages and disadvantages of HIFU as a thermal therapy, it is important to understand the underlying physics of ultrasound tissue interactions. The first lecture in the session will provide an overview of the physics of ultrasound wave propagation; the mechanism for the accumulation of heat in soft-tissue; image-guidance modalities including temperature monitoring; current clinical applications and commercial devices; active clinical trials; alternate mechanisms of action (future of FUS). The second part of the session will compare HIFU to existing ionization radiation techniques. The difficulties in defining a clear concept of absorbed dose for HIFU will be discussed. Some of the technical challenges that HIFU faces will be described, with an emphasis on how the experience of radiation oncology physicists could benefit the field. Learning Objectives: Describe the basic physics and biology of HIFU, including treatment delivery and image guidance techniques. Summarize existing and emerging clinical applications and manufacturers for HIFU. Understand that thermal ablation with HIFU is likely the first of several applications of the technology Learn about some similarities and differences between HIFU and ionizing radiation in terms of physics and biological effects. Learn about some of the technical challenges HIFU faces that might benefit from the experience of radiation oncology physicists including treatment planning improvements, quality assurance procedures, and treatment risk analysis. David Schlesinger receives research support from Elekta Instruments, AB. Matt Eames is an employee of the Focused Ultrasound Foundation which supports research and clinical trials. Dr. Eames conducts research which is supported by the Focused Ultrasound Foundation.

  12. TU-A-210-01: HIFU Physics and Delivery

    Energy Technology Data Exchange (ETDEWEB)

    Eames, M. [Focused Ultrasound Foundation (United States)

    2015-06-15

    High-intensity focused ultrasound (HIFU) has developed rapidly in recent years and is used frequently for clinical treatments in Asia and Europe with increasing clinical use and clinical trial activity in the US, making it an important medical technology with which the medical physics community must become familiar. Akin to medical devices that deliver treatments using ionizing radiation, HIFU relies on emitter geometry to non-invasively form a tight focus that can be used to affect diseased tissue while leaving healthy tissue intact. HIFU is unique in that it does not involve the use of ionizing radiation, it causes thermal necrosis in 100% of the treated tissue volume, and it has an immediate treatment effect. However, because it is an application of ultrasound energy, HIFU interacts strongly with tissue interfaces, which makes treatment planning challenging. In order to appreciate the advantages and disadvantages of HIFU as a thermal therapy, it is important to understand the underlying physics of ultrasound tissue interactions. The first lecture in the session will provide an overview of the physics of ultrasound wave propagation; the mechanism for the accumulation of heat in soft-tissue; image-guidance modalities including temperature monitoring; current clinical applications and commercial devices; active clinical trials; alternate mechanisms of action (future of FUS). The second part of the session will compare HIFU to existing ionization radiation techniques. The difficulties in defining a clear concept of absorbed dose for HIFU will be discussed. Some of the technical challenges that HIFU faces will be described, with an emphasis on how the experience of radiation oncology physicists could benefit the field. Learning Objectives: Describe the basic physics and biology of HIFU, including treatment delivery and image guidance techniques. Summarize existing and emerging clinical applications and manufacturers for HIFU. Understand that thermal ablation with HIFU is likely the first of several applications of the technology Learn about some similarities and differences between HIFU and ionizing radiation in terms of physics and biological effects. Learn about some of the technical challenges HIFU faces that might benefit from the experience of radiation oncology physicists including treatment planning improvements, quality assurance procedures, and treatment risk analysis. David Schlesinger receives research support from Elekta Instruments, AB. Matt Eames is an employee of the Focused Ultrasound Foundation which supports research and clinical trials. Dr. Eames conducts research which is supported by the Focused Ultrasound Foundation.

  13. Tu eres gallo… pero la de los huevos soy yo

    OpenAIRE

    Pine, Adrienne

    2011-01-01

    En Honduras, la industria maquiladora con sus prácticas disciplinarias y modernas, es vista por muchas personas como una fuerza protectora contra la violencia extrema de las maras y de las calles que es el enfoque principal del discurso diario hondureño. Sin embargo, la industria maquiladora, y las políticas militares y neoliberales (implementados por el fmi y el Banco Mundial) de las cuáles se aprovecha directamente, están estrechamente ligados con las prácticas de violencia asociadas al gén...

  14. TU-CD-213-04: Panel Discussion

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, J. [MD Anderson Cancer Center (United States)

    2015-06-15

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration.

  15. TU-CD-213-04: Panel Discussion

    International Nuclear Information System (INIS)

    Johnson, J.

    2015-01-01

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration

  16. TU-AB-204-01: Device Approval Process

    Energy Technology Data Exchange (ETDEWEB)

    Delfino, J. [Food & Drug Administration (United States)

    2016-06-15

    The responsibilities of the Food and Drug Administration (FDA) have increased since the inception of the Food and Drugs Act in 1906. Medical devices first came under comprehensive regulation with the passage of the 1938 Food, Drug, and Cosmetic Act. In 1971 FDA also took on the responsibility for consumer protection against unnecessary exposure to radiation-emitting devices for home and occupational use. However it was not until 1976, under the Medical Device Regulation Act, that the FDA was responsible for the safety and effectiveness of medical devices. This session will be presented by the Division of Radiological Health (DRH) and the Division of Imaging, Diagnostics, and Software Reliability (DIDSR) from the Center for Devices and Radiological Health (CDRH) at the FDA. The symposium will discuss on how we protect and promote public health with a focus on medical physics applications organized into four areas: pre-market device review, post-market surveillance, device compliance, current regulatory research efforts and partnerships with other organizations. The pre-market session will summarize the pathways FDA uses to regulate the investigational use and commercialization of diagnostic imaging and radiation therapy medical devices in the US, highlighting resources available to assist investigators and manufacturers. The post-market session will explain the post-market surveillance and compliance activities FDA performs to monitor the safety and effectiveness of devices on the market. The third session will describe research efforts that support the regulatory mission of the Agency. An overview of our regulatory research portfolio to advance our understanding of medical physics and imaging technologies and approaches to their evaluation will be discussed. Lastly, mechanisms that FDA uses to seek public input and promote collaborations with professional, government, and international organizations, such as AAPM, International Electrotechnical Commission (IEC), Image Gently, and the Quantitative Imaging Biomarkers Alliance (QIBA) among others, to fulfill FDA’s mission will be discussed. Learning Objectives: Understand FDA’s pre-market and post-market review processes for medical devices Understand FDA’s current regulatory research activities in the areas of medical physics and imaging products Understand how being involved with AAPM and other organizations can also help to promote innovative, safe and effective medical devices J. Delfino, nothing to disclose.

  17. TU-EF-BRD-02: Indicators and Technique Analysis

    International Nuclear Information System (INIS)

    Carlone, M.

    2015-01-01

    Research related to quality and safety has been a staple of medical physics academic activities for a long time. From very early on, medical physicists have developed new radiation measurement equipment and analysis techniques, created ever increasingly accurate dose calculation models, and have vastly improved imaging, planning, and delivery techniques. These and other areas of interest have improved the quality and safety of radiotherapy for our patients. With the advent of TG-100, quality and safety is an area that will garner even more research interest in the future. As medical physicists pursue quality and safety research in greater numbers, it is worthwhile to consider what actually constitutes research on quality and safety. For example, should the development of algorithms for real-time EPID-based in-vivo dosimetry be defined as “quality and safety” research? How about the clinical implementation of such as system? Surely the application of failure modes and effects analysis to a clinical process would be considered quality and safety research, but is this type of research that should be included in the medical physics peer-reviewed literature? The answers to such questions are of critical importance to set researchers in a direction that will provide the greatest benefit to our field and the patients we serve. The purpose of this symposium is to consider what constitutes research in the arena of quality and safety and differentiate it from other research directions. The key distinction here is developing the tool itself (e.g. algorithms for EPID dosimetry) vs. studying the impact of the tool with some quantitative metric. Only the latter would I call quality and safety research. Issues of ‘basic’ versus ‘applied’ quality and safety research will be covered as well as how the research results should be structured to provide increasing levels of support that a quality and safety intervention is effective and sustainable. Examples from existing peer-reviewed research will be used to highlight the main points. Historical, medical physicists have leveraged many areas of applied physics, engineering and biology to improve radiotherapy. Research on quality and safety is another area where physicists can have an impact. The key to further progress is to clearly define what constitutes quality and safety research for those interested in doing such research and the reviewers of that research. Learning Objectives: List several tools of quality and safety with references to peer-reviewed literature. Describe effects of mental workload on performance. Outline research in quality and safety indicators and technique analysis. Understand what quality and safety research needs to be going forward. Understand the links between cooperative group trials and quality and safety research

  18. TU-D-201-01: 2016 Economics Update

    Energy Technology Data Exchange (ETDEWEB)

    Fontenot, J [Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Fuss, W [Health Policy Solutions, Delray Beach, FL (United States)

    2016-06-15

    The purpose of this session is to introduce attendees to the healthcare reimbursement system and how it applies to the clinical work of a medical physicist. This will include general information about the different categories of payers and payees, how work is described by CPT codes, and how various payers set values for this work in different clinical settings. 2016 is another year of significant changes to the payment system. This presentation will describe the work encompassed in these codes and will give attendees an overview of the changes for 2016 as they apply to radiation oncology. Finally, some insight into what can be expected during 2017 will be presented. This includes what information is typically released by the Centers for Medicaid and Medicare Services (CMS) during the year and how we as an organization respond. This will include ways members can interact with the AAPM professional economics committee and other resources members may find helpful. Learning objectives1) Basics of how Medicare is structured and how reimbursement rates are set.2) Basic understanding of proposed changes to the 2016 Medicare rules.3) Describe economics and policy resources that are available from the AAPM and how to interact with the professional economics committee.

  19. TU-F-16A-01: Communicating Risk

    International Nuclear Information System (INIS)

    McCollough, C; Kofler, J; Wagner, L; Brateman, L

    2014-01-01

    The radiobiological risks associated with medical imaging are generally considered to be small, if existent. However, the public view of the risk of medical radiation at diagnostic levels can be substantially different from the clinical reality. Radiation science is not taught to the general public, and so perception of radiation risks can be based on a variety sources, including some that may be misleading, incorrect, or sensationalized. Consequently, patients can have significant concerns about procedures they or their loved ones might have had or that might be needed in their medical care. It is the responsibility of the physicist to be able to communicate risk in a manner that is clear, understandable, and respectful. This session will present a number of real life scenarios of patient or family concern about radiation risks. The panel will, through demonstration or discussion, present various options for handling each situation. The audience will be involved in discussion and critique of the approaches presented. Learning Objectives: To gain insight to the patients perspective on radiation risk and how to respond professionally to their concerns. To learn basic principles for effectively communicating with patients about radiation risk. To gain tools and approaches for addressing a wide range of patient concerns

  20. TU-AB-BRD-03: Fault Tree Analysis

    International Nuclear Information System (INIS)

    Dunscombe, P.

    2015-01-01

    Current quality assurance and quality management guidelines provided by various professional organizations are prescriptive in nature, focusing principally on performance characteristics of planning and delivery devices. However, published analyses of events in radiation therapy show that most events are often caused by flaws in clinical processes rather than by device failures. This suggests the need for the development of a quality management program that is based on integrated approaches to process and equipment quality assurance. Industrial engineers have developed various risk assessment tools that are used to identify and eliminate potential failures from a system or a process before a failure impacts a customer. These tools include, but are not limited to, process mapping, failure modes and effects analysis, fault tree analysis. Task Group 100 of the American Association of Physicists in Medicine has developed these tools and used them to formulate an example risk-based quality management program for intensity-modulated radiotherapy. This is a prospective risk assessment approach that analyzes potential error pathways inherent in a clinical process and then ranks them according to relative risk, typically before implementation, followed by the design of a new process or modification of the existing process. Appropriate controls are then put in place to ensure that failures are less likely to occur and, if they do, they will more likely be detected before they propagate through the process, compromising treatment outcome and causing harm to the patient. Such a prospective approach forms the basis of the work of Task Group 100 that has recently been approved by the AAPM. This session will be devoted to a discussion of these tools and practical examples of how these tools can be used in a given radiotherapy clinic to develop a risk based quality management program. Learning Objectives: Learn how to design a process map for a radiotherapy process Learn how to perform failure modes and effects analysis analysis for a given process Learn what fault trees are all about Learn how to design a quality management program based upon the information obtained from process mapping, failure modes and effects analysis and fault tree analysis. Dunscombe: Director, TreatSafely, LLC and Center for the Assessment of Radiological Sciences; Consultant to IAEA and Varian Thomadsen: President, Center for the Assessment of Radiological Sciences Palta: Vice President of the Center for the Assessment of Radiological Sciences

  1. TU-EF-210-02: MRg Hyperthermia

    Energy Technology Data Exchange (ETDEWEB)

    Chopra, R. [UT Southwestern Medical Ctr at Dallas (United States)

    2015-06-15

    The use of therapeutic ultrasound to provide targeted therapy is an active research area that has a broad application scope. The invited talks in this session will address currently implemented strategies and protocols for both hyperthermia and ablation applications using therapeutic ultrasound. The role of both ultrasound and MRI in the monitoring and assessment of these therapies will be explored in both pre-clinical and clinical applications. Katherine Ferrara: High Intensity Focused Ultrasound, Drug Delivery, and Immunotherapy Rajiv Chopra: Translating Localized Doxorubicin Delivery to Pediatric Oncology using MRI-guided HIFU Elisa Konofagou: Real-time Ablation Monitoring and Lesion Quantification using Harmonic Motion Imaging Keyvan Farahani: AAPM Task Groups in Interventional Ultrasound Imaging and Therapy Learning Objectives: Understand the role of ultrasound in localized drug delivery and the effects of immunotherapy when used in conjunction with ultrasound therapy. Understand potential targeted drug delivery clinical applications including pediatric oncology. Understand the technical requirements for performing targeted drug delivery. Understand how radiation-force approaches can be used to both monitor and assess high intensity focused ultrasound ablation therapy. Understand the role of AAPM task groups in ultrasound imaging and therapies. Chopra: Funding from Cancer Prevention and Research Initiative of Texas (CPRIT), Award R1308 Evelyn and M.R. Hudson Foundation; Research Support from Research Contract with Philips Healthcare; COI are Co-founder of FUS Instruments Inc Ferrara: Supported by NIH, UCDavis and California (CIRM and BHCE) Farahani: In-kind research support from Philips Healthcare.

  2. TU-EF-210-02: MRg Hyperthermia

    International Nuclear Information System (INIS)

    Chopra, R.

    2015-01-01

    The use of therapeutic ultrasound to provide targeted therapy is an active research area that has a broad application scope. The invited talks in this session will address currently implemented strategies and protocols for both hyperthermia and ablation applications using therapeutic ultrasound. The role of both ultrasound and MRI in the monitoring and assessment of these therapies will be explored in both pre-clinical and clinical applications. Katherine Ferrara: High Intensity Focused Ultrasound, Drug Delivery, and Immunotherapy Rajiv Chopra: Translating Localized Doxorubicin Delivery to Pediatric Oncology using MRI-guided HIFU Elisa Konofagou: Real-time Ablation Monitoring and Lesion Quantification using Harmonic Motion Imaging Keyvan Farahani: AAPM Task Groups in Interventional Ultrasound Imaging and Therapy Learning Objectives: Understand the role of ultrasound in localized drug delivery and the effects of immunotherapy when used in conjunction with ultrasound therapy. Understand potential targeted drug delivery clinical applications including pediatric oncology. Understand the technical requirements for performing targeted drug delivery. Understand how radiation-force approaches can be used to both monitor and assess high intensity focused ultrasound ablation therapy. Understand the role of AAPM task groups in ultrasound imaging and therapies. Chopra: Funding from Cancer Prevention and Research Initiative of Texas (CPRIT), Award R1308 Evelyn and M.R. Hudson Foundation; Research Support from Research Contract with Philips Healthcare; COI are Co-founder of FUS Instruments Inc Ferrara: Supported by NIH, UCDavis and California (CIRM and BHCE) Farahani: In-kind research support from Philips Healthcare

  3. TU-C-218-02: Effective Oncology Physics Education.

    Science.gov (United States)

    Burmeister, J; Coffey, C; Salehpour, M; Ibbott, G

    2012-06-01

    The education of medical physicists has historically been quite varied and medical physicists have entered the field through several pathways including specialized educational programs, postdoctoral fellowships, and on-the-job training. It is argued that the contributions of viewpoints from different branches of physics has contributed to the development of novel solutions and advances in radiation oncology. However, there also has been an effort recently to make graduate education of medical physicists more consistent and uniform, particularly for the preparation of clinically oriented therapy physicists. The trend towards a more systematic approach has been guided in part by the requirements for graduate program accreditation developed by CAMPEP and by the requirements for medical physicist certification by the ABR. At the same time, there has been criticism of this approach as being too confining and guiding graduates toward a career as technicians rather than independent thinkers. Educational programs have had to balance the requirements of accreditation and certification against the goal of preparing students for careers as independent researchers. Three speakers will describe the approaches taken by their graduate educational programs to meet the requirements of CAMPEP and adequately prepare graduates for certification by the ABR, while maintaining a commitment to providing a comprehensive education in medical physics. 1. Understand the requirements for graduate program accreditation 2. Understand the education and experience requirements for certification 3. Learn the approaches taken by several graduate programs to meet the requirements for accreditation and certification while providing a comprehensive education in medical physics. © 2012 American Association of Physicists in Medicine.

  4. TU-AB-BRD-04: Development of Quality Management Program

    International Nuclear Information System (INIS)

    Thomadsen, B.

    2015-01-01

    Current quality assurance and quality management guidelines provided by various professional organizations are prescriptive in nature, focusing principally on performance characteristics of planning and delivery devices. However, published analyses of events in radiation therapy show that most events are often caused by flaws in clinical processes rather than by device failures. This suggests the need for the development of a quality management program that is based on integrated approaches to process and equipment quality assurance. Industrial engineers have developed various risk assessment tools that are used to identify and eliminate potential failures from a system or a process before a failure impacts a customer. These tools include, but are not limited to, process mapping, failure modes and effects analysis, fault tree analysis. Task Group 100 of the American Association of Physicists in Medicine has developed these tools and used them to formulate an example risk-based quality management program for intensity-modulated radiotherapy. This is a prospective risk assessment approach that analyzes potential error pathways inherent in a clinical process and then ranks them according to relative risk, typically before implementation, followed by the design of a new process or modification of the existing process. Appropriate controls are then put in place to ensure that failures are less likely to occur and, if they do, they will more likely be detected before they propagate through the process, compromising treatment outcome and causing harm to the patient. Such a prospective approach forms the basis of the work of Task Group 100 that has recently been approved by the AAPM. This session will be devoted to a discussion of these tools and practical examples of how these tools can be used in a given radiotherapy clinic to develop a risk based quality management program. Learning Objectives: Learn how to design a process map for a radiotherapy process Learn how to perform failure modes and effects analysis analysis for a given process Learn what fault trees are all about Learn how to design a quality management program based upon the information obtained from process mapping, failure modes and effects analysis and fault tree analysis. Dunscombe: Director, TreatSafely, LLC and Center for the Assessment of Radiological Sciences; Consultant to IAEA and Varian Thomadsen: President, Center for the Assessment of Radiological Sciences Palta: Vice President of the Center for the Assessment of Radiological Sciences

  5. Portal web de servicios adecua tu casa.com

    OpenAIRE

    Aguirre Sanabria, Marco; Galio Molina, Gustavo Humberto

    2009-01-01

    El objetivo principal del desarrollo de este portal como complemento de estrategias de e-marketing para obtener clientes potenciales en el área de la construcción y, aprovechando las tecnologías de Internet es proporcionar y dar a conocer a usuarios, los distintos servicios que ofrece la empresa constructora Makurdi S.A. tales como: construcción, remodelación, ampliación adecuación, acabados e instalaciones eléctricas y sanitarias, utilizando mano de obra calificada que permitan garantizar la...

  6. TU-F-BRD-01: Biomedical Informatics for Medical Physicists

    International Nuclear Information System (INIS)

    Phillips, M; Kalet, I; McNutt, T; Smith, W

    2014-01-01

    Biomedical informatics encompasses a very large domain of knowledge and applications. This broad and loosely defined field can make it difficult to navigate. Physicists often are called upon to provide informatics services and/or to take part in projects involving principles of the field. The purpose of the presentations in this symposium is to help medical physicists gain some knowledge about the breadth of the field and how, in the current clinical and research environment, they can participate and contribute. Three talks have been designed to give an overview from the perspective of physicists and to provide a more in-depth discussion in two areas. One of the primary purposes, and the main subject of the first talk, is to help physicists achieve a perspective about the range of the topics and concepts that fall under the heading of 'informatics'. The approach is to de-mystify topics and jargon and to help physicists find resources in the field should they need them. The other talks explore two areas of biomedical informatics in more depth. The goal is to highlight two domains of intense current interest--databases and models--in enough depth into current approaches so that an adequate background for independent inquiry is achieved. These two areas will serve as good examples of how physicists, using informatics principles, can contribute to oncology practice and research. Learning Objectives: To understand how the principles of biomedical informatics are used by medical physicists. To put the relevant informatics concepts in perspective with regard to biomedicine in general. To use clinical database design as an example of biomedical informatics. To provide a solid background into the problems and issues of the design and use of data and databases in radiation oncology. To use modeling in the service of decision support systems as an example of modeling methods and data use. To provide a background into how uncertainty in our data and knowledge can be incorporated into modeling methods

  7. Energy Flexible Buildings, Case study: TU Delft campus, The Netherlands

    NARCIS (Netherlands)

    Mlecnik, E.; Hellinga, C.; Stoelinga, P.

    2018-01-01

    In-depth knowledge from demonstrations is needed for the future development of facility management, related to the introduction of energy-saving devices, buildings and energy systems. Particularly there is a need to understand better how the concept of Energy Flexibility can effect energy saving

  8. Rule based design workshop at the TU Berlin

    DEFF Research Database (Denmark)

    Tamke, Martin; Palz, Norbert; Josefsson, Kristoffer

    and design concepts to lead into a second workshop further exploring digital design and fabrication tools. The goal is to produce a full-scale prototype to test the ideas, methods and materials. This paper focuses on digital design & fabrication via a pedagogical exploration between academics...

  9. Poniendo tu granito de arena: Latinos and HIV.

    Science.gov (United States)

    Vazquez, E

    1999-01-01

    Because the Latino community often lacks the money and power of large, white-run agencies in HIV prevention efforts, Latino HIV-service providers often turn to bootstrap efforts that are well-grounded in cultural realities. The community response to HIV prevention efforts is examined in terms of the cultural sensitivity needed to reach this ethnic group more effectively. Reasons why grassroots efforts are more effective in a Latino community than traditional agencies, and some examples of successful programs are outlined. The discrepancies seen in HIV services due to lack of resources and connections to needed funding are also discussed. Discussions on the Latino understanding of fatalism, homophobia, family values, and machismo that all affect the spread of HIV are highlighted.

  10. On proper Shapley values for monotone TU-games

    NARCIS (Netherlands)

    van den Brink, J.R.; Levinsky, R.; Zeleny, M.

    2015-01-01

    The Shapley value of a cooperative transferable utility game distributes the dividend of each coalition in the game equally among its members. Given exogenous weights for all players, the corresponding weighted Shapley value distributes the dividends proportionally to their weights. A proper Shapley

  11. Un chercheur du CERN tué dans un accident

    CERN Multimedia

    2008-01-01

    The accident occured on Sunday between Collonges and Pougnu (Pays de Gex): 4 russians scientists were aboard the vehicle; the driver lost the control of the vehicle and the car made a barrel. (1/4 page)

  12. T/U expansion for the Hubbard model

    Energy Technology Data Exchange (ETDEWEB)

    MacDonald, A.H.; Girvin, S.M.; Yoshioka, D.

    1988-06-01

    We describe a unitary transformation which eliminates terms coupling states with differing numbers of doubly occupied sites from the Hamiltonian of the Hubbard model. The S matrix for the transformation, and the transformed Hamiltonian, H', are generated by an iterative procedure which results in an expansion in powers of the hopping integral t divided by the on-site energy U. For a half-filled band and in the space with no doubly occupied sites, H' is equivalent to a spin Hamiltonian. We discuss the implications of our results for H' on theories of high-temperature superconductivity.

  13. The TU Delft Online Learning Experience: From Theory to Practice

    NARCIS (Netherlands)

    Ribeiro Jorge, N.; Dopper, S.M.; van Valkenburg, W.F.

    2016-01-01

    Last year, when we presented the OLE at the 2015 EDEN Conference in Barcelona, we were still at an early stage of its development, collecting fundamental background to support it and feedback from online learning experts. Although we only had a collection of ideas translated into 8 principles, it

  14. ATTACHMENT STUDY OF AGROBACTERIUM TuMEPACIrNs TO

    African Journals Online (AJOL)

    dicot plant cells, but also monocots notably corn and brome grass (Bromus inermis) bind as many bacterial cells as does D. innoxia (Lippincott and. Lippincott, 1975). Monocot cell walls were thought to have fewer bacterial attachment sites than dicots, which would account for the lack of tumour formation in some monocots.

  15. ¿Crees que tu voz es única?

    OpenAIRE

    Cerdà Massó, Ramon

    2011-01-01

    Desde el punto de vista forense —o, más exactamente, criminalístico—, la unicidad de la voz no se puede dilucidar como la experiencia cotidiana, de manera intuitiva. Lo ideal sería establecer qué rasgos digitalmente identificados conforman la voz de cada uno, incluso por encima de alteraciones voluntarias o inconscientes debidas a cambios ambientales o a trastornos biológicos. Mientras esto se ha conseguido desde hace años por lo que respecta a rasgos generales, necesarios para la identificac...

  16. TU-EF-BRA-00: MR Basics I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    NMR, and Proton Density MRI of the 1D Patient - Anthony Wolbarst Net Voxel Magnetization, m(x,t). T1-MRI; The MRI Device - Lisa Lemen ‘Classical’ NMR; FID Imaging in 1D via k-Space - Nathan Yanasak Spin-Echo; S-E/Spin Warp in a 2D Slice - Ronald Price Magnetic resonance imaging not only reveals the structural, anatomic details of the body, as does CT, but also it can provide information on the physiological status and pathologies of its tissues, like nuclear medicine. It can display high-quality slice and 3D images of organs and vessels viewed from any perspective, with resolution better than 1 mm. MRI is perhaps most extraordinary and notable for the plethora of ways in which it can create unique forms of image contrast, reflective of fundamentally different biophysical phenomena. As with ultrasound, there is no risk from ionizing radiation to the patient or staff, since no X-rays or radioactive nuclei are involved. Instead, MRI harnesses magnetic fields and radio waves to probe the stable nuclei of the ordinary hydrogen atoms (isolated protons) occurring in water and lipid molecules within and around cells. MRI consists, in essence, of creating spatial maps of the electromagnetic environments around these hydrogen nuclei. Spatial variations in the proton milieus can be related to clinical differences in the biochemical and physiological properties and conditions of the associated tissues. Imaging of proton density (PD), and of the tissue proton spin relaxation times known as T1 and T2, all can reveal important clinical information, but they do so with approaches so dissimilar from one another that each is chosen for only certain clinical situations. T1 and T2 in a voxel are determined by different aspects of the rotations and other motions of the water and lipid molecules involved, as constrained by the local biophysical surroundings within and between its cells – and they, in turn, depend on the type of tissue and its state of health. Three other common applications of MRI exploit its capability to detect and image distinct movements of fluids: MR angiography (MRA), which rivals CT angiography but often requires no contrast medium, monitors the bulk flow of blood; functional MRI (f MRI), distinguishes the perfusion of oxygenated blood from that of de-oxygenated, and lights up parts of the brain that are activated by a stimulus, rather like PET; and diffusion tensor imaging (DTI) indicates the diffusion of free water along tracts of axons, thereby bringing nerve trunks into view. There are variants on all of these themes, and on others as well. Magnetic Resonance Spectroscopy (MRS), for example, can perform non-invasive ‘virtual biopsies’ that allow identification of certain cancers and other lesions. And an MRI-guided needle biopsy can sample brain tissue from a region only millimeters in dimensions. MRI, however, involves deeper and more complex aspects of physics, technology, and biology than do most other imaging modalities, and it is widely considered to be correspondingly more difficult to learn. We could probably cover all of this rather comprehensively if we had 50 hours available rather than 2 ̶ but, to paraphrase a former Secretary of Defense, you tell your story in the time you have allotted. The four presenters and another physicist, Kevin King from GE, have combined their efforts to co-author a single slide show that describes essentials of MRI as simply as possible. It is obviously far from thorough, but hopefully it will succeed in explaining some of the basics in a simplified but still valid fashion; in providing a taste of the numerous capabilities and complexities of the modality; and in whetting your appetite to learn more. Part I. NMR, and Proton Density MRI of the 1D Patient (Wolbarst), begins with an introductory case study that illustrates a half dozen ways in which MRI provides valuable clinical information. It then explores the nuclear magnetic resonance (NMR) phenomenon, which underlies MRI. NMR can be introduced with either of two approaches. In the first, one thinks (loosely) of the nuclei of hydrogen atoms as (rotating and charged and therefore) magnetic objects, whose spin-axes tend to align in a strong external magnetic field, much like a compass needle. As with the Bohr atom, this spin-up/spin-down picture is a highly abridged version of the full quantum mechanical treatment, but still it leads to some useful, legitimate pictures of the NMR process occurring within a voxel: When RF photons of the correct (Larmor) frequency elevate protons in a fixed magnetic field out of their lower-energy spin state into the upper, the NMR phenomenon is indicated by the detectable absorption of RF power. With the addition of a linear gradient field along a multi-voxel, one-dimensional patient/phantom, as well, we can determine the water content of each compartment – an example of a real MRI study, albeit in 1D. Part I concludes with a discussion of the net magnetization at position x, m0(x), under conditions of dynamic thermal equilibrium, which leads into: Part II. Net Voxel Magnetization, m(x,t); T1-MRI; The MRI Device (Lemen), investigates the biophysics of the form of proton spin relaxation process characterized by the time T1. It then moves on to the creation of an MR image that displays the spatial variation in the values of this clinically relevant parameter, again in 1D. Finally, the design and workings of a clinical MRI machine are sketched, in preparation for: Part III. ‘Classical’ NMR; FID Imaging in 1D via k-Space (Yanasak) presents the second standard approach to NMR and MRI, the classical model. It focuses on the time dependence of the net nuclear magnetization, m(x,t), the overall magnetic field generated by the cohort of protons in the voxel at position x. Quite remarkably, this nuclear net magnetization itself acts in a strong magnetic field like a gyroscope in a gravitational field. This tack is better for explaining Free Induction Decay (FID), which involves a brief introduction to the Fourier transform and k-space. This leads to conventional Spin-Echo (S-E) reconstruction techniques for creating clinical images from raw data, and sets the stage for: Part IV. Spin-Echo; S-E / Spin Warp in a 2D Slice (Price) discusses application of the S- E sequence of radiofrequency pulses and gradient magnetic fields to the 1D patient. T2 is introduced but not explained. This Part also considers how to manipulate the image acquisition parameters so as to generate clinical pictures with contrast dominated by spatial variations in PD, T1, or T2. We conclude by demonstrating the spin-warp approach to imaging in 2D with a simple 2×2, 4-voxel example. Much of this material is presented in more detail in the chapter “MRI of the One-dimensional Patient, Part I”, in Advances in Medical Physics, Vol 5 (2014). Copies are on display at the Medical Physics Publishing booth. Learning Objectives: The participant will learn about the processes of NMR and T1 spin relaxation in a tissue voxel in a uniform magnetic field. The participant will learn about combining spin-up/spin-down NMR and T1 processes with a linear gradient to effect frequency-encoding of voxel spatial position. This approach can be used to create proton density and T1 MRI maps, respectively, of the contents of multi-voxel 1D phantoms. The participant will learn about how the ‘classical’ model of NMR it can generate Free Induction Decay (FID) images of 1D phantoms, which involves the use of the Fourier transform in k-space. This can lead simply into standard Spin-Echo images. The participant will learn about extending Spin-Echo imaging into 2 and more dimensions.

  17. Tu(r)ning weakness to strength: Mechanomutable bioinspired materials

    Science.gov (United States)

    2017-04-03

    Chemistry and Microbiology Student Symposium (ECMSS), The Pennsylvania State University, State College , PA March 2014 - "Biomateriomics: Multiscale...Kaplan, M.J. Buehler, “Materials by Design: Merging Proteins and Music ,” Nano Today, DOI: 10.1016/j.nantod.2012.09.001, 2012 • J. Zang, S. Ryu, N...Silk (editors: Tetsuo Asakura and Thomas A. Miller), Springer, 2014 Students that were supported throughout the years, students graduated - Zhao Qin

  18. TU-EF-207-00: Advances in Breast Imaging

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  19. TU-AB-204-01: Device Approval Process

    International Nuclear Information System (INIS)

    Delfino, J.

    2016-01-01

    The responsibilities of the Food and Drug Administration (FDA) have increased since the inception of the Food and Drugs Act in 1906. Medical devices first came under comprehensive regulation with the passage of the 1938 Food, Drug, and Cosmetic Act. In 1971 FDA also took on the responsibility for consumer protection against unnecessary exposure to radiation-emitting devices for home and occupational use. However it was not until 1976, under the Medical Device Regulation Act, that the FDA was responsible for the safety and effectiveness of medical devices. This session will be presented by the Division of Radiological Health (DRH) and the Division of Imaging, Diagnostics, and Software Reliability (DIDSR) from the Center for Devices and Radiological Health (CDRH) at the FDA. The symposium will discuss on how we protect and promote public health with a focus on medical physics applications organized into four areas: pre-market device review, post-market surveillance, device compliance, current regulatory research efforts and partnerships with other organizations. The pre-market session will summarize the pathways FDA uses to regulate the investigational use and commercialization of diagnostic imaging and radiation therapy medical devices in the US, highlighting resources available to assist investigators and manufacturers. The post-market session will explain the post-market surveillance and compliance activities FDA performs to monitor the safety and effectiveness of devices on the market. The third session will describe research efforts that support the regulatory mission of the Agency. An overview of our regulatory research portfolio to advance our understanding of medical physics and imaging technologies and approaches to their evaluation will be discussed. Lastly, mechanisms that FDA uses to seek public input and promote collaborations with professional, government, and international organizations, such as AAPM, International Electrotechnical Commission (IEC), Image Gently, and the Quantitative Imaging Biomarkers Alliance (QIBA) among others, to fulfill FDA’s mission will be discussed. Learning Objectives: Understand FDA’s pre-market and post-market review processes for medical devices Understand FDA’s current regulatory research activities in the areas of medical physics and imaging products Understand how being involved with AAPM and other organizations can also help to promote innovative, safe and effective medical devices J. Delfino, nothing to disclose

  20. TU-AB-BRD-02: Failure Modes and Effects Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Huq, M. [University of Pittsburgh Medical Center (United States)

    2015-06-15

    Current quality assurance and quality management guidelines provided by various professional organizations are prescriptive in nature, focusing principally on performance characteristics of planning and delivery devices. However, published analyses of events in radiation therapy show that most events are often caused by flaws in clinical processes rather than by device failures. This suggests the need for the development of a quality management program that is based on integrated approaches to process and equipment quality assurance. Industrial engineers have developed various risk assessment tools that are used to identify and eliminate potential failures from a system or a process before a failure impacts a customer. These tools include, but are not limited to, process mapping, failure modes and effects analysis, fault tree analysis. Task Group 100 of the American Association of Physicists in Medicine has developed these tools and used them to formulate an example risk-based quality management program for intensity-modulated radiotherapy. This is a prospective risk assessment approach that analyzes potential error pathways inherent in a clinical process and then ranks them according to relative risk, typically before implementation, followed by the design of a new process or modification of the existing process. Appropriate controls are then put in place to ensure that failures are less likely to occur and, if they do, they will more likely be detected before they propagate through the process, compromising treatment outcome and causing harm to the patient. Such a prospective approach forms the basis of the work of Task Group 100 that has recently been approved by the AAPM. This session will be devoted to a discussion of these tools and practical examples of how these tools can be used in a given radiotherapy clinic to develop a risk based quality management program. Learning Objectives: Learn how to design a process map for a radiotherapy process Learn how to perform failure modes and effects analysis analysis for a given process Learn what fault trees are all about Learn how to design a quality management program based upon the information obtained from process mapping, failure modes and effects analysis and fault tree analysis. Dunscombe: Director, TreatSafely, LLC and Center for the Assessment of Radiological Sciences; Consultant to IAEA and Varian Thomadsen: President, Center for the Assessment of Radiological Sciences Palta: Vice President of the Center for the Assessment of Radiological Sciences.

  1. TU-AB-BRD-03: Fault Tree Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Dunscombe, P. [University of Calgary (Canada)

    2015-06-15

    Current quality assurance and quality management guidelines provided by various professional organizations are prescriptive in nature, focusing principally on performance characteristics of planning and delivery devices. However, published analyses of events in radiation therapy show that most events are often caused by flaws in clinical processes rather than by device failures. This suggests the need for the development of a quality management program that is based on integrated approaches to process and equipment quality assurance. Industrial engineers have developed various risk assessment tools that are used to identify and eliminate potential failures from a system or a process before a failure impacts a customer. These tools include, but are not limited to, process mapping, failure modes and effects analysis, fault tree analysis. Task Group 100 of the American Association of Physicists in Medicine has developed these tools and used them to formulate an example risk-based quality management program for intensity-modulated radiotherapy. This is a prospective risk assessment approach that analyzes potential error pathways inherent in a clinical process and then ranks them according to relative risk, typically before implementation, followed by the design of a new process or modification of the existing process. Appropriate controls are then put in place to ensure that failures are less likely to occur and, if they do, they will more likely be detected before they propagate through the process, compromising treatment outcome and causing harm to the patient. Such a prospective approach forms the basis of the work of Task Group 100 that has recently been approved by the AAPM. This session will be devoted to a discussion of these tools and practical examples of how these tools can be used in a given radiotherapy clinic to develop a risk based quality management program. Learning Objectives: Learn how to design a process map for a radiotherapy process Learn how to perform failure modes and effects analysis analysis for a given process Learn what fault trees are all about Learn how to design a quality management program based upon the information obtained from process mapping, failure modes and effects analysis and fault tree analysis. Dunscombe: Director, TreatSafely, LLC and Center for the Assessment of Radiological Sciences; Consultant to IAEA and Varian Thomadsen: President, Center for the Assessment of Radiological Sciences Palta: Vice President of the Center for the Assessment of Radiological Sciences.

  2. TU-AB-BRD-00: Task Group 100

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    Current quality assurance and quality management guidelines provided by various professional organizations are prescriptive in nature, focusing principally on performance characteristics of planning and delivery devices. However, published analyses of events in radiation therapy show that most events are often caused by flaws in clinical processes rather than by device failures. This suggests the need for the development of a quality management program that is based on integrated approaches to process and equipment quality assurance. Industrial engineers have developed various risk assessment tools that are used to identify and eliminate potential failures from a system or a process before a failure impacts a customer. These tools include, but are not limited to, process mapping, failure modes and effects analysis, fault tree analysis. Task Group 100 of the American Association of Physicists in Medicine has developed these tools and used them to formulate an example risk-based quality management program for intensity-modulated radiotherapy. This is a prospective risk assessment approach that analyzes potential error pathways inherent in a clinical process and then ranks them according to relative risk, typically before implementation, followed by the design of a new process or modification of the existing process. Appropriate controls are then put in place to ensure that failures are less likely to occur and, if they do, they will more likely be detected before they propagate through the process, compromising treatment outcome and causing harm to the patient. Such a prospective approach forms the basis of the work of Task Group 100 that has recently been approved by the AAPM. This session will be devoted to a discussion of these tools and practical examples of how these tools can be used in a given radiotherapy clinic to develop a risk based quality management program. Learning Objectives: Learn how to design a process map for a radiotherapy process Learn how to perform failure modes and effects analysis analysis for a given process Learn what fault trees are all about Learn how to design a quality management program based upon the information obtained from process mapping, failure modes and effects analysis and fault tree analysis. Dunscombe: Director, TreatSafely, LLC and Center for the Assessment of Radiological Sciences; Consultant to IAEA and Varian Thomadsen: President, Center for the Assessment of Radiological Sciences Palta: Vice President of the Center for the Assessment of Radiological Sciences.

  3. TU-AB-BRD-04: Development of Quality Management Program

    Energy Technology Data Exchange (ETDEWEB)

    Thomadsen, B. [University of Wisconsin (United States)

    2015-06-15

    Current quality assurance and quality management guidelines provided by various professional organizations are prescriptive in nature, focusing principally on performance characteristics of planning and delivery devices. However, published analyses of events in radiation therapy show that most events are often caused by flaws in clinical processes rather than by device failures. This suggests the need for the development of a quality management program that is based on integrated approaches to process and equipment quality assurance. Industrial engineers have developed various risk assessment tools that are used to identify and eliminate potential failures from a system or a process before a failure impacts a customer. These tools include, but are not limited to, process mapping, failure modes and effects analysis, fault tree analysis. Task Group 100 of the American Association of Physicists in Medicine has developed these tools and used them to formulate an example risk-based quality management program for intensity-modulated radiotherapy. This is a prospective risk assessment approach that analyzes potential error pathways inherent in a clinical process and then ranks them according to relative risk, typically before implementation, followed by the design of a new process or modification of the existing process. Appropriate controls are then put in place to ensure that failures are less likely to occur and, if they do, they will more likely be detected before they propagate through the process, compromising treatment outcome and causing harm to the patient. Such a prospective approach forms the basis of the work of Task Group 100 that has recently been approved by the AAPM. This session will be devoted to a discussion of these tools and practical examples of how these tools can be used in a given radiotherapy clinic to develop a risk based quality management program. Learning Objectives: Learn how to design a process map for a radiotherapy process Learn how to perform failure modes and effects analysis analysis for a given process Learn what fault trees are all about Learn how to design a quality management program based upon the information obtained from process mapping, failure modes and effects analysis and fault tree analysis. Dunscombe: Director, TreatSafely, LLC and Center for the Assessment of Radiological Sciences; Consultant to IAEA and Varian Thomadsen: President, Center for the Assessment of Radiological Sciences Palta: Vice President of the Center for the Assessment of Radiological Sciences.

  4. Comet P/2001 TU 80 (Linear-Neat)

    Czech Academy of Sciences Publication Activity Database

    Kušnirák, Peter

    č. 7753 (2001), s. 1 ISSN 0081-0304 R&D Projects: GA ČR GA205/99/0255 Institutional research plan: CEZ:AV0Z1003909 Keywords : comets * astrometry Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

  5. Hegelova teorie mravního státu

    Czech Academy of Sciences Publication Activity Database

    Chotaš, Jiří

    2003-01-01

    Roč. 51, č. 2 (2003), s. 275-291 ISSN 0015-1831 R&D Projects: GA ČR GA401/03/0863 Institutional research plan: CEZ:AV0Z9009908 Keywords : state * ethical state * Hegel * Popper Subject RIV: AA - Philosophy ; Religion

  6. Changing culture - the experience of TU Delft Library

    NARCIS (Netherlands)

    Heijne, M.; Van der Sar, E.

    2004-01-01

    When seeking to introduce change into an organisation, it is usually the organisational structure that is the main focus of attention. A reorganisation, however, does not necessarily resolve underlying cultural problems. It can, in fact, be just these cultural problems that prevent the organisation

  7. TU-EF-BRD-03: Mental Workload and Performance

    International Nuclear Information System (INIS)

    Mazur, L.

    2015-01-01

    Research related to quality and safety has been a staple of medical physics academic activities for a long time. From very early on, medical physicists have developed new radiation measurement equipment and analysis techniques, created ever increasingly accurate dose calculation models, and have vastly improved imaging, planning, and delivery techniques. These and other areas of interest have improved the quality and safety of radiotherapy for our patients. With the advent of TG-100, quality and safety is an area that will garner even more research interest in the future. As medical physicists pursue quality and safety research in greater numbers, it is worthwhile to consider what actually constitutes research on quality and safety. For example, should the development of algorithms for real-time EPID-based in-vivo dosimetry be defined as “quality and safety” research? How about the clinical implementation of such as system? Surely the application of failure modes and effects analysis to a clinical process would be considered quality and safety research, but is this type of research that should be included in the medical physics peer-reviewed literature? The answers to such questions are of critical importance to set researchers in a direction that will provide the greatest benefit to our field and the patients we serve. The purpose of this symposium is to consider what constitutes research in the arena of quality and safety and differentiate it from other research directions. The key distinction here is developing the tool itself (e.g. algorithms for EPID dosimetry) vs. studying the impact of the tool with some quantitative metric. Only the latter would I call quality and safety research. Issues of ‘basic’ versus ‘applied’ quality and safety research will be covered as well as how the research results should be structured to provide increasing levels of support that a quality and safety intervention is effective and sustainable. Examples from existing peer-reviewed research will be used to highlight the main points. Historical, medical physicists have leveraged many areas of applied physics, engineering and biology to improve radiotherapy. Research on quality and safety is another area where physicists can have an impact. The key to further progress is to clearly define what constitutes quality and safety research for those interested in doing such research and the reviewers of that research. Learning Objectives: List several tools of quality and safety with references to peer-reviewed literature. Describe effects of mental workload on performance. Outline research in quality and safety indicators and technique analysis. Understand what quality and safety research needs to be going forward. Understand the links between cooperative group trials and quality and safety research

  8. ¿Qué tan verde es tu mercado?

    Directory of Open Access Journals (Sweden)

    Wilmar R. Olaya-González

    2011-01-01

    Full Text Available El mercado de lo verde y lo ecológico es una tendencia indiscutible en nuestro mundo globalizado, que busca de alguna manera resarcir el daño infringido sobre el medio ambiente. Más allá de simple altruismo, la ecología se ha convertido en una moda, de la cual unos y otros toman ventaja a su mejor acomodo, haciendo del mercado de productos y servicios su tribuna; eco-diseño, planes de responsabilidad social y ambiental, campañas por el reciclaje y consumo de productos "más amigables" con el medio ambiente hacen parte del panorama que se intenta describir en esta reseña. Por medio de un estudio de caso, se hará énfasis en cómo la comunicación asume un papel crucial en la verdadera apropiación del concepto de "consumidor verde" y "consumidor responsable", de manera que la propuesta transversal de las tic se convierta en una herramienta no solo tecnológica, sino también de empoderamiento del papel que la sociedad puede representar en el cuidado de los recursos naturales.

  9. TU-A-210-01: HIFU Physics and Delivery

    International Nuclear Information System (INIS)

    Eames, M.

    2015-01-01

    High-intensity focused ultrasound (HIFU) has developed rapidly in recent years and is used frequently for clinical treatments in Asia and Europe with increasing clinical use and clinical trial activity in the US, making it an important medical technology with which the medical physics community must become familiar. Akin to medical devices that deliver treatments using ionizing radiation, HIFU relies on emitter geometry to non-invasively form a tight focus that can be used to affect diseased tissue while leaving healthy tissue intact. HIFU is unique in that it does not involve the use of ionizing radiation, it causes thermal necrosis in 100% of the treated tissue volume, and it has an immediate treatment effect. However, because it is an application of ultrasound energy, HIFU interacts strongly with tissue interfaces, which makes treatment planning challenging. In order to appreciate the advantages and disadvantages of HIFU as a thermal therapy, it is important to understand the underlying physics of ultrasound tissue interactions. The first lecture in the session will provide an overview of the physics of ultrasound wave propagation; the mechanism for the accumulation of heat in soft-tissue; image-guidance modalities including temperature monitoring; current clinical applications and commercial devices; active clinical trials; alternate mechanisms of action (future of FUS). The second part of the session will compare HIFU to existing ionization radiation techniques. The difficulties in defining a clear concept of absorbed dose for HIFU will be discussed. Some of the technical challenges that HIFU faces will be described, with an emphasis on how the experience of radiation oncology physicists could benefit the field. Learning Objectives: Describe the basic physics and biology of HIFU, including treatment delivery and image guidance techniques. Summarize existing and emerging clinical applications and manufacturers for HIFU. Understand that thermal ablation with HIFU is likely the first of several applications of the technology Learn about some similarities and differences between HIFU and ionizing radiation in terms of physics and biological effects. Learn about some of the technical challenges HIFU faces that might benefit from the experience of radiation oncology physicists including treatment planning improvements, quality assurance procedures, and treatment risk analysis. David Schlesinger receives research support from Elekta Instruments, AB. Matt Eames is an employee of the Focused Ultrasound Foundation which supports research and clinical trials. Dr. Eames conducts research which is supported by the Focused Ultrasound Foundation

  10. ¡Abre tu cerebro! Descubre la Neurociencia Cognitiva

    Directory of Open Access Journals (Sweden)

    Ángel Correa

    2007-11-01

    Full Text Available En el presente Año de la Ciencia, el gobierno español apuesta por la divulgación científica. Numerosas actividades acercarán a todos los públicos los conocimientos sobre el cerebro y la mente humana desde la Neurociencia Cognitiva.

  11. ¡Abre tu cerebro! Descubre la Neurociencia Cognitiva

    OpenAIRE

    Ángel Correa

    2007-01-01

    En el presente Año de la Ciencia, el gobierno español apuesta por la divulgación científica. Numerosas actividades acercarán a todos los públicos los conocimientos sobre el cerebro y la mente humana desde la Neurociencia Cognitiva.

  12. TU-EF-BRA-00: MR Basics I

    International Nuclear Information System (INIS)

    2015-01-01

    NMR, and Proton Density MRI of the 1D Patient - Anthony Wolbarst Net Voxel Magnetization, m(x,t). T1-MRI; The MRI Device - Lisa Lemen ‘Classical’ NMR; FID Imaging in 1D via k-Space - Nathan Yanasak Spin-Echo; S-E/Spin Warp in a 2D Slice - Ronald Price Magnetic resonance imaging not only reveals the structural, anatomic details of the body, as does CT, but also it can provide information on the physiological status and pathologies of its tissues, like nuclear medicine. It can display high-quality slice and 3D images of organs and vessels viewed from any perspective, with resolution better than 1 mm. MRI is perhaps most extraordinary and notable for the plethora of ways in which it can create unique forms of image contrast, reflective of fundamentally different biophysical phenomena. As with ultrasound, there is no risk from ionizing radiation to the patient or staff, since no X-rays or radioactive nuclei are involved. Instead, MRI harnesses magnetic fields and radio waves to probe the stable nuclei of the ordinary hydrogen atoms (isolated protons) occurring in water and lipid molecules within and around cells. MRI consists, in essence, of creating spatial maps of the electromagnetic environments around these hydrogen nuclei. Spatial variations in the proton milieus can be related to clinical differences in the biochemical and physiological properties and conditions of the associated tissues. Imaging of proton density (PD), and of the tissue proton spin relaxation times known as T1 and T2, all can reveal important clinical information, but they do so with approaches so dissimilar from one another that each is chosen for only certain clinical situations. T1 and T2 in a voxel are determined by different aspects of the rotations and other motions of the water and lipid molecules involved, as constrained by the local biophysical surroundings within and between its cells – and they, in turn, depend on the type of tissue and its state of health. Three other common applications of MRI exploit its capability to detect and image distinct movements of fluids: MR angiography (MRA), which rivals CT angiography but often requires no contrast medium, monitors the bulk flow of blood; functional MRI (f MRI), distinguishes the perfusion of oxygenated blood from that of de-oxygenated, and lights up parts of the brain that are activated by a stimulus, rather like PET; and diffusion tensor imaging (DTI) indicates the diffusion of free water along tracts of axons, thereby bringing nerve trunks into view. There are variants on all of these themes, and on others as well. Magnetic Resonance Spectroscopy (MRS), for example, can perform non-invasive ‘virtual biopsies’ that allow identification of certain cancers and other lesions. And an MRI-guided needle biopsy can sample brain tissue from a region only millimeters in dimensions. MRI, however, involves deeper and more complex aspects of physics, technology, and biology than do most other imaging modalities, and it is widely considered to be correspondingly more difficult to learn. We could probably cover all of this rather comprehensively if we had 50 hours available rather than 2 ̶ but, to paraphrase a former Secretary of Defense, you tell your story in the time you have allotted. The four presenters and another physicist, Kevin King from GE, have combined their efforts to co-author a single slide show that describes essentials of MRI as simply as possible. It is obviously far from thorough, but hopefully it will succeed in explaining some of the basics in a simplified but still valid fashion; in providing a taste of the numerous capabilities and complexities of the modality; and in whetting your appetite to learn more. Part I. NMR, and Proton Density MRI of the 1D Patient (Wolbarst), begins with an introductory case study that illustrates a half dozen ways in which MRI provides valuable clinical information. It then explores the nuclear magnetic resonance (NMR) phenomenon, which underlies MRI. NMR can be introduced with either of two approaches. In the first, one thinks (loosely) of the nuclei of hydrogen atoms as (rotating and charged and therefore) magnetic objects, whose spin-axes tend to align in a strong external magnetic field, much like a compass needle. As with the Bohr atom, this spin-up/spin-down picture is a highly abridged version of the full quantum mechanical treatment, but still it leads to some useful, legitimate pictures of the NMR process occurring within a voxel: When RF photons of the correct (Larmor) frequency elevate protons in a fixed magnetic field out of their lower-energy spin state into the upper, the NMR phenomenon is indicated by the detectable absorption of RF power. With the addition of a linear gradient field along a multi-voxel, one-dimensional patient/phantom, as well, we can determine the water content of each compartment – an example of a real MRI study, albeit in 1D. Part I concludes with a discussion of the net magnetization at position x, m0(x), under conditions of dynamic thermal equilibrium, which leads into: Part II. Net Voxel Magnetization, m(x,t); T1-MRI; The MRI Device (Lemen), investigates the biophysics of the form of proton spin relaxation process characterized by the time T1. It then moves on to the creation of an MR image that displays the spatial variation in the values of this clinically relevant parameter, again in 1D. Finally, the design and workings of a clinical MRI machine are sketched, in preparation for: Part III. ‘Classical’ NMR; FID Imaging in 1D via k-Space (Yanasak) presents the second standard approach to NMR and MRI, the classical model. It focuses on the time dependence of the net nuclear magnetization, m(x,t), the overall magnetic field generated by the cohort of protons in the voxel at position x. Quite remarkably, this nuclear net magnetization itself acts in a strong magnetic field like a gyroscope in a gravitational field. This tack is better for explaining Free Induction Decay (FID), which involves a brief introduction to the Fourier transform and k-space. This leads to conventional Spin-Echo (S-E) reconstruction techniques for creating clinical images from raw data, and sets the stage for: Part IV. Spin-Echo; S-E / Spin Warp in a 2D Slice (Price) discusses application of the S- E sequence of radiofrequency pulses and gradient magnetic fields to the 1D patient. T2 is introduced but not explained. This Part also considers how to manipulate the image acquisition parameters so as to generate clinical pictures with contrast dominated by spatial variations in PD, T1, or T2. We conclude by demonstrating the spin-warp approach to imaging in 2D with a simple 2×2, 4-voxel example. Much of this material is presented in more detail in the chapter “MRI of the One-dimensional Patient, Part I”, in Advances in Medical Physics, Vol 5 (2014). Copies are on display at the Medical Physics Publishing booth. Learning Objectives: The participant will learn about the processes of NMR and T1 spin relaxation in a tissue voxel in a uniform magnetic field. The participant will learn about combining spin-up/spin-down NMR and T1 processes with a linear gradient to effect frequency-encoding of voxel spatial position. This approach can be used to create proton density and T1 MRI maps, respectively, of the contents of multi-voxel 1D phantoms. The participant will learn about how the ‘classical’ model of NMR it can generate Free Induction Decay (FID) images of 1D phantoms, which involves the use of the Fourier transform in k-space. This can lead simply into standard Spin-Echo images. The participant will learn about extending Spin-Echo imaging into 2 and more dimensions

  13. TU-AB-BRC-06: Dose Calculation in Curved Space

    Energy Technology Data Exchange (ETDEWEB)

    Kieselmann, J; Bartzsch, S; Oelfke, U [The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London (United Kingdom)

    2016-06-15

    Purpose: Microbeam Radiation Therapy is a preclinical method in radiation oncology that modulates radiation fields on a micrometre scale. Dose calculation is challenging due to arising dose gradients and therapeutically important dose ranges. Monte Carlo (MC) simulations, often used as gold standard, are computationally expensive and hence too slow for the optimisation of treatment parameters in future clinical applications. On the other hand, conventional kernel based dose calculation leads to inaccurate results close to material interfaces. The purpose of this work is to overcome these inaccuracies while keeping computation times low. Methods: A point kernel superposition algorithm is modified to account for tissue inhomogeneities. Instead of conventional ray tracing approaches, methods from differential geometry are applied and the space around the primary photon interaction is locally warped. The performance of this approach is compared to MC simulations and a simple convolution algorithm (CA) for two different phantoms and photon spectra. Results: While peak doses of all dose calculation methods agreed within less than 4% deviations, the proposed approach surpassed a simple convolution algorithm in accuracy by a factor of up to 3 in the scatter dose. In a treatment geometry similar to possible future clinical situations differences between Monte Carlo and the differential geometry algorithm were less than 3%. At the same time the calculation time did not exceed 15 minutes. Conclusion: With the developed method it was possible to improve the dose calculation based on the CA method with respect to accuracy especially at sharp tissue boundaries. While the calculation is more extensive than for the CA method and depends on field size, the typical calculation time for a 20×20 mm{sup 2} field on a 3.4 GHz and 8 GByte RAM processor remained below 15 minutes. Parallelisation and optimisation of the algorithm could lead to further significant calculation time reductions.

  14. TU-FG-201-09: Predicting Accelerator Dysfunction

    International Nuclear Information System (INIS)

    Able, C; Nguyen, C; Baydush, A; Munley, M; Gersh, J; Ndlovu, A; Rebo, I; Booth, J; Perez, M; Sintay, B

    2016-01-01

    Purpose: To develop an integrated statistical process control (SPC) framework using digital performance and component data accumulated within the accelerator system that can detect dysfunction prior to unscheduled downtime. Methods: Seven digital accelerators were monitored for twelve to 18 months. The accelerators were operated in a ‘run to failure mode’ with the individual institutions determining when service would be initiated. Institutions were required to submit detailed service reports. Trajectory and text log files resulting from a robust daily VMAT QA delivery were decoded and evaluated using Individual and Moving Range (I/MR) control charts. The SPC evaluation was presented in a customized dashboard interface that allows the user to review 525 monitored parameters (480 MLC parameters). Chart limits were calculated using a hybrid technique that includes the standard SPC 3σ limits and an empirical factor based on the parameter/system specification. The individual (I) grand mean values and control limit ranges of the I/MR charts of all accelerators were compared using statistical (ranked analysis of variance (ANOVA)) and graphical analyses to determine consistency of operating parameters. Results: When an alarm or warning was directly connected to field service, process control charts predicted dysfunction consistently on beam generation related parameters (BGP)– RF Driver Voltage, Gun Grid Voltage, and Forward Power (W); beam uniformity parameters – angle and position steering coil currents; and Gantry position accuracy parameter: cross correlation max-value. Control charts for individual MLC – cross correlation max-value/position detected 50% to 60% of MLCs serviced prior to dysfunction or failure. In general, non-random changes were detected 5 to 80 days prior to a service intervention. The ANOVA comparison of BGP determined that each accelerator parameter operated at a distinct value. Conclusion: The SPC framework shows promise. Long term monitoring coordinated with service will be required to definitively determine the effectiveness of the model. Varian Medical System, Inc. provided funding in support of the research presented.

  15. TU-CD-BRD-00: Incident Learning / RO-ILS

    International Nuclear Information System (INIS)

    2015-01-01

    It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set aside for audience members to contribute to the discussion. Learning Objectives: Learn how to promote the use of an incident learning system in a clinic. Learn how to convert “event reporting” into “incident learning”. See examples of practice changes that have come out of learning systems. Learn how the RO-ILS system can be used as a primary internal learning system. Learn how to create succinct, meaningful reports useful to outside readers. Gary Ezzell chairs the AAPM committee overseeing RO-ILS and has received an honorarium from ASTRO for working on the committee reviewing RO-ILS reports. Derek Brown is a director of http://TreatSafely.org . Brett Miller has previously received travel expenses and an honorarium from Varian. Phillip Beron has nothing to report

  16. L’INTRODUCTION DES NOUVELLES TECHNOLOGIES DE L’IMAGE DANS LA TRANSMISSION DES SAVOIRS ARCHITECTURAUX: L’IMPACT SUR LA CONCEPTION ARCHITECTURALE ET LA REPRESENTATION DU PROJET

    Directory of Open Access Journals (Sweden)

    M FOURA

    2001-12-01

    Full Text Available L’introduction des nouvelles technologies de l’image touche de plein fouet l’architecture par ce qui lui permet d’être conçue, élaborée et communiquée: la conception et la représentation. Cette nouvelle possibilité d’accès aux informations d’un projet produit évidemment un nouveau type de communication et donc une nouvelle attitude d’analyse du projet.  Dans cet article, il s’agit de mettre en évidence les enjeux conceptuels de l’introduction des nouvelles technologies dans le champ de la représentation du projet d’architecture, postulant qu’il ne s’agit pas d’un simple développement des représentations traditionnelles, mais d’un bouleversement par rapport à des procédés traditionnels de la conception architecturale qui datent de la Renaissance.

  17. Espaces documentaires, espaces de savoir, espaces d'expérience : vers une (re)définition du modèle des CDI ?

    OpenAIRE

    Maury , Yolande

    2011-01-01

    International audience; This paper explores the Documentation and Information Centres (CDI) as physical and symbolic spaces, at the heart of knowledge organization. The research is based on two previous research projects (2001-2005; 2006-2010) on high school education in France. Findings show evolutions that question established models.; Cette communication interroge les Centres de Documentation et d'Information (CDI) en tant qu'espaces physiques et symboliques, au coeur de l'organisation et ...

  18. La mise en ordre écologique des parcs urbains. Savoirs, pratiques et paysages : Exemple d'un grand parc francilien

    OpenAIRE

    Legrand , Marine

    2015-01-01

    In France, local public authorities have taken a growing interest in ecological landscape management of urban parks and gardens since the 1980’s. It results in the emergence of a new landscape model that embodies the encounter between two tendencies in urban territories. First, the growing influence of biological sciences on urban planning through the “urban ecology” political horizon. Second, the enlargement of nature conservation policies, that starts to include ordinary nature and urban bi...

  19. Oulebsir Nabila et Volait Mercedes (dir., L’Orientalisme architectural entre imaginaires et savoirs, Paris, CNRS et Picard, 2009, 300 p.

    Directory of Open Access Journals (Sweden)

    Rémi Labrusse

    2009-11-01

    Full Text Available D’usage potentiellement aussi large qu’est vague la notion d’Orient dont il est issu, le terme « orientalisme », en histoire de l’art et de l’architecture, sert le plus souvent, faute de mieux, à caractériser l’emploi de formes issues des arts de l’Islam, décontextualisées puis réappropriées dans le cadre de pratiques propres à la culture occidentale (celles-ci fussent-elles endossées par des artistes non-occidentaux. Ces pratiques, le xixe siècle, pour des raisons à la fois scientifiques (l...

  20. Everything you need to know to operate on Day-Ahead{sup TM}; Tout ce que vous devez savoir pour intervenir sur Powernext Day-Ahead{sup TM}

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-05-15

    The introduction of a power exchange in France is a direct response to the opening up of the European electricity markets. Powernext SA is a Multilateral Trading Facility in charge of managing the French power exchange through an optional and anonymous organised exchange offering: - Day-ahead contracts for the management of volume risk on Powernext Day-Ahead{sup TM} since 21 November 2001, - Medium term contracts for the management of price risk on Powernext Futures{sup TM} since 18 June 2004. This document is the user's guide of Powernext Day-Ahead{sup TM}. It presents: 1 - the power exchange in France (market model, Powernext's regulatory environment, general market operations, 2 - Powernext Day-Ahead{sup TM} members (membership, agreement, start-up notification, tariffs, standing obligations, membership termination), 3 - Powernext Day-Ahead{sup TM} products (specifications, management), 4 - trading (connections, system flow chart, ElWeb client installation and daily connections, portfolio-management, single bidding, type of order, submitting, importing, saving, sending, modifying or canceling an order form, transmission problems, block bidding block bid characteristics, sending, saving, transmitting, modifying and canceling a block bid, price calculations, blind auction procedure, example, taking into account block bids, rounding off rules, consulting and saving the results, sample documents, auction validation), 5 - clearing (LCH.Clearnet SA, legal framework, clearing agreement, PP-DPES agreement, market security, initial margin, daily adjustments, additional margin calls, trade-related financial flows, net financial position, value-added tax, settlement statements, general idea, characteristics and transmission method of settlement statements sample Documents, cash calls, settlement, default, sample cash call documents, financial Reports), 6 - delivery (balance responsible entity, file characteristics and transmission, imbalance settlement, interconnection access), contacts and glossary.

  1. L’Université de Perpignan au XVIIIe siècle : palais et temple du savoir à l’âge des Lumières

    Directory of Open Access Journals (Sweden)

    Esteban Castañer Muñoz

    2012-01-01

    Full Text Available L’édifice de l’ancienne Université de Perpignan fut construit en 1759 par l’Ingénieur Lescure. Louis XV, à la demande du gouverneur de Mailly, voulut faire de Perpignan une ville des Lumières. La construction de l’Université avait dans ce contexte une signification particulière. Le bâtisseur s’inspira des modèles architecturaux du palais et du temple suivant les orientations stylistiques de la deuxième moitié du XVIIIe siècle. Avec son amphithéâtre d’anatomie, l’ancienne université de Perpignan est l’un des ensembles universitaires du XVIIIe siècle le plus complet encore existant en France.The former buildings of the University of Perpignan date back to 1759 and were designed by an engineer: Lescure. King Louis XV attending the request of Governor de Mailly wanted to turn Perpignan into a city of the Enlightenment. Considering this circumstance the university buildings themselves had a specific significance. The master-builder was inspired by the style of the palaces and the temples that were built during the second half of the 18th Century. The former University of Perpignan and its anatomy lecture hall constitutes one of the best examples of a well preserved 18th Century French university.

  2. Policies, Administration, and Management: As published in "Distances et Savoirs" (D & S--7/2009. A La Croisee des Recherches, pages 627 to 641)

    Science.gov (United States)

    Thompson, Melody M.; Vidal, Martine

    2011-01-01

    The chapters in Part IV of "Handbook of Distance Education" (2007), "Policies, Administration, and Management," focus on the ways in which policies encourage or hamper the integration of distance education into mainstream educational institutions. The authors provide insights and perspectives into the key policies, roles, structures, processes,…

  3. Savoirs experts et idiome quotidien. Biens et vertus de la conception participative des velos de quartiers à Trois-Rivières

    Directory of Open Access Journals (Sweden)

    Philippe Gauthier

    2010-11-01

    Full Text Available This paper analyzes the development of a public bike system initiated by a civic organization that treats participation as a core principle. The analysis shows that the satisfaction of the goals pursued through the adoption of participative principles, amongst which the respect of citizens' personal experiences in the design of their world, is a difficult task. The near identity between the system designed with the help of citizens and other systems offered by large industrial companies cast doubt on the capacity of the participative principles to produce outputs that would represent genuine alternatives to careless design. The difficulty stems from the willingness to take participatory procedures as necessary conditions to the realization of democratic ideals in modern liberal societies. Putting forward principles for their own sake drives us away from the ideals of liberal democracy that promote efficiency in the actions we adopt, over and above sole obedience to a common practice.RÉSUMÉDans ce texte, nous analysons la mise en place d’un système de vélos partagés à Trois-Rivières initié par un organisme faisant de la participation citoyenne son principe fondamental d’action. Cette analyse montre comment l’atteinte des objectifs poursuivis par l’adhésion à ce principe participatif, outre le respect de l’expérience du citoyen dans le développement de son milieu de vie, peut poser problème. La similarité entre le système de vélos conçu avec la participation des citoyens et les systèmes offerts par les groupes industriels met en question la capacité du principe de la participation à produire des solutions alternatives. La difficulté relèverait de la volonté de faire des méthodes participatives un principe nécessaire à la réalisation des idéaux démocratiques des sociétés libérales modernes. Promulguer l’obéissance à des procédures d’action communes, pour elles-mêmes, nous éloigne d’une conception libérale de la démocratie qui s’attache d’abord à l’efficacité de l’action, donc à la qualité de ce qu’elle produit, indépendamment des moyens mis en œuvre.

  4. Caractérisation du savoir paysan sur les insectes nuisibles du pois d'Angole (Cajanus Cajan (L. Millsp. dans le Nord de l'Ouganda

    Directory of Open Access Journals (Sweden)

    Velay F.

    2001-01-01

    Full Text Available Characterization of indigenous traditional knowledge on insect pests of pigeonpea (Cajanus cajan (L. Millsp. in Northern Uganda. In order to assess the perception of the main insect pests of pigeonpea (Cajanus cajan (L. Millsp. by small farmers and to inventoriate methods traditionally used to control these insects, a survey was conducted in 41 households of Northern Uganda (Lira and Apac districts. Virtually all small farmers (95/ considered blister beetle (Mylabris sp., which is the most conspicious insect damaging pigeonpea at the flowering stage, as the main pest of the crop. This is conflicting with field observations made earlier in Northern Uganda which pointed out pod borers (Helicoverpa armigera Huebner and Maruca vitrata Geyer and pod sucking bugs (mainly Clavigralla sp. as the most damaging pests for pigeonpea production. A new pest of pigeonpea, Luprops baldius Mueller, was identified during this survey. Its adults and larvae are damaging to mature pods in case of late harvest.

  5. Le savoir de l’Europe sur la Chine : transferts franco-allemands au miroir des encyclopédies (1750-1850)

    OpenAIRE

    Lehner, Georg

    2011-01-01

    Les dictionnaires encyclopédiques français et surtout la Description... de la Chine de Du Halde ont influencé durablement les informations sur la Chine contenues dans les encyclopédies allemandes. Toutefois, cette reprise et cette diffusion des travaux français ont également eu des effets en retour et ont conduit à de véritables interactions entre les encyclopédies allemandes et françaises. Les encyclopédies françaises portent mention des travaux des savants allemands ainsi que de leur écho e...

  6. La caravane des animaux. Circulation des « orangs-outans » et des savoirs, reconfigurations des frontières de l’humain

    OpenAIRE

    Sebastiani, Silvia

    2018-01-01

    L’article interroge la présence des animaux exotiques dans la Grande-Bretagne des Lumières, et en particulier des « orangs-outans ». Il retrace la mobilité de ces bêtes, met en lumière les réseaux au long cours de leur circulation, dessine les multiples espaces de sociabilité de leur mise en observation et le foisonnement des registres de discours dont ils font l’objet. Mis au cœur des travaux d’anatomie comparée dès la fin du xviie siècle, les orangs-outans deviennent l’une des grandes attra...

  7. Rodina dnes: veřejný vzdělávací cyklus Université de tous les savoirs

    Czech Academy of Sciences Publication Activity Database

    Dudová, Radka

    2005-01-01

    Roč. 6, č. 1 (2005), s. 51-52 ISSN 1213-0028 R&D Projects: GA AV ČR(CZ) 1QS700280503; GA AV ČR(CZ) KJB700280503 Institutional research plan: CEZ:AV0Z70280505 Keywords : family * lecture * French sociology Subject RIV: AO - Sociology , Demography www.genderonline.cz

  8. Des méthodes et des hommes. La production sociale du savoir sur l’efficacité de la peine de mort

    OpenAIRE

    Raoult, Sacha

    2015-01-01

    International audience; Forschungen zur abschreckenden Wirkung von Strafen haben eine beeindruckende Quantität erreicht, aller-dings mit widersprüchlichen und schwer verdaulichen Ergebnissen. Eine Untersuchung der Forschergruppen, die über die Korrelationen von Mord und Todesstrafe arbeiten, erlaubt die Identifikation einer« laute Minderheit », die für die abschreckende Wirkung der Todesstrafe plädiert. Die Kenntnis eines Autors stellt einen bedeutenderen Prädiktor für die Ergebnisse der empi...

  9. Académies et création du savoir scientifique: circulation des idées et mécanismes de la censure

    Directory of Open Access Journals (Sweden)

    Patrizia Delpiano

    2016-12-01

    Full Text Available [Academies and the creation of scientific knowledge: the circulation of ideas and censorships mechanisms]. This article analyses how European academies contributed to shape the idea of scientific truth in the second half of XVIIIth century. It focuses on the role played by academics in disseminating certain theories and censoring other ones, destined to be considered as false beliefs. Two theories stand out: mesmerism, connected to the Viennese physician Franz Anton Mesmer, and the nouvelle chimie, connected to the chemical revolution implemented by Antoine-Laurent Lavoisier. The criteria of scientific truth elaborated by academics influenced the reception of the two theories in France and Italy: mesmerism was received with popular enthusiasm while was condemned by the academic world as the invention of a charlatan; on the opposite, Lavoisier’s chemistry, after initial resistances, was accepted at the institutional level.

  10. Des Ecritures illicites. Le savoir des agents de la sureté sur l’écrit à Paris (1871-1900

    Directory of Open Access Journals (Sweden)

    Philippe Artières

    2011-03-01

    Full Text Available Ce rapport est celui d’un policier parisien en date du 29 décembre 1884 ; ce regard sur des écrits tracés sur un mur paraît aujourd’hui banal tant la lutte contre le graffiti (« contre le vandalisme » fait partie des prérogatives policières. Il n’en était rien, il y a cent cinquante ans : ce constat d’écriture illicite constitue un événement aussi minuscule que considérable : il s’inscrit dans un moment important de redéfinition des fonctions du policier2 ; il inaugure un regard et sa pratique ; le policier précise non seulement le siège de l’écrit mais sa taille, sa couleur, son support et sa consistance. L’agent indique aussi le trouble provoqué, ce qu’aujourd’hui on nomme la saillance d’un écrit. Comment un tel constat d’écriture a-t-il été rendu possible ? Quel intérêt pouvait pousser un policier faisant sa ronde à noter, avec tant de soins, quelques signes traces à la peinture verte ? Pourquoi soudain cet écrit en public devient suspect ? Et surtout pour ces inspecteurs qu’est-ce qui constitue dans leur fonction l’acte d’écrire en un acte à observer et à décrire dans un rapport ?

  11. Plantes tinctoriales des traditions et sociétés du Pacifique : de la sauvegarde des savoirs aux nouvelles perspectives d'application

    OpenAIRE

    Cardon, D.; Cabalion, Pierre; Blanc, B.; Boulanger-Penduff, M.; Hnawia, E.; Nowik, W.; Waikedre, Jean; Sam, C.

    2010-01-01

    Les colorants naturels, utilisés depuis les temps préhistoriques, sont principalement extraits du monde végétal. Les applications des plantes tinctoriales ont concerné non seulement textiles et vannerie, mais aussi la peinture ou teinture de la peau et des cuirs, des cheveux et poils, etc. Des exemples de leur importance dans le patrimoine culturel des sociétés du Pacifique sont présentés, en développant celui de recherches interdisciplinaires récentes, d'ordre botanique, chimique et anthropo...

  12. Le savoir-faire local dans la valorisation alimentaire des fruits du safoutier (Dacryodes edulis (G. Don H.J. Lam au Cameroun

    Directory of Open Access Journals (Sweden)

    Noumi, GB.

    2006-01-01

    Full Text Available The Local Know-how in the Valorisation of (Dacryodes edulis (G. Don H.J. Lam Fruits in Cameroon. Dacryodes edulis (G. Don H.J. Lam (Burseraceae is an oleaginous plant highly appreciated in the forest zone of Cameroon. This tree yields fruits called african pear or safou, highly consumed by local populations and even abroad. African pear is at the centre of a great economic activity in the Central Africa subregion as its trade generates cash for local traders during the production period. However, the valorisation of african pear is hindered by its high perishable nature responsible for important post-harvest losses due to lack of proper post-harvest handling. Some studies addressed the problem, unfortunately, nothing was done on the local know-how which has still to be investigated. The present paper sheds light on african pear local harvesting, handling and marketing practices in Cameroon. Field surveys were carried out in different production zones in Cameroon savannah and humid forest lowlands: Adamawa, centre, east, littoral and west provinces. Results showed that african pear occupies an important place in the population daily life. This multipurpose tree specie appears to be a source of foodstuffs, cash income, drugs and wood. If, on one hand diverse strategies are developed by the population for a proper conservation of fruits, on the other hand there is not a real fruits transformation activity. Results of this study highlight the traditional know-how and bring out prospects for future works on african pear valorisation.

  13. PROPOS SUR LE SAVOIR-FAIRE DES ETUDIANTS NON-PHILOLOGUES ACQUIS PAR DES APPROCHES PLURIELLES. ETUDE DE CAS : LE METALANGAGE

    Directory of Open Access Journals (Sweden)

    Constantin Felicia

    2012-07-01

    Full Text Available The Framework of reference for pluralistic approaches to languages and cultures (CARAP, developed in 2007 under Michel Candelier’s coordination is an imperative instrument for all the teachers and decision makers preoccupied with the didactic stances of plurilinguism. Much less known than the Common European Framework of Reference for Languages, CARAP provides an inventory of knowledge, attitudes and skills the students will get to master within certain plural didactic approaches, oriented towards the development of plurilinguism. These didactic approaches are profoundly original compared with a traditional training path. We will consider as a reference point for our reflection one of the most promising and dynamic plural approaches: intercomprehension, more exactly the model developed by the InterCompréhension Européenne (ICE team of the University of Reims, France. The census of knowledge, attitudes and skills allows a systematic look on linguistic and cultural realities that the future plurilinguistic individual is meant to assimilate. Our attention will be focused on skills. Attending the ICE meetings made us familiar with a running manner excluding the preoccupation for the acquiring of a complete foreign language grammar, circumscribed to assuming its partial knowledge, in one or two of the competences defining it (written and oral understanding. The results of the experiments allow us to state that a minimum of grammar is enough to get the access to the global understanding of texts written in a foreign language: « intercomprehenders » getting involved in the global understanding of foreign languages previously unknown, related to their mother tongue, using a very reduced metalanguage, complementary with a wide range of relieve strategies. This observation has led to our professional activity, marked by the recurrent confrontation with the reality of teaching classes – economic students’ inability to remember, understand, and naturally use a significant part of the grammar metalanguage acquired in their mother tongue. To emphasize this, we applied an empirical survey related to the fundamental grammar terminology in their mother tongue and interpreted the answers of a significant number of first and second year students of the Faculty of Economics. The results prove a disquieting inability to manage the already acquired morphological and syntactical categories within grammar analysis of mother tongue and subsequently transferred to the process of teaching-acquiring foreign languages. We have established a contiguity between the natural path in a training session in ICE type intercomprehension and the didactic path in institutional education, concluding that (1 a simplification of the grammar taught within traditional education is beneficial for students and teacher and that (2 the use of certain intercomprehensive techniques, such as the parangon, is extremely profitable when approaching certain aspects connected to foreign language grammar.

  14. Vision d‘avenir pour la recherche en agriculture biologique à l‘horizon 2025. Un savoir bio pour l‘avenir

    OpenAIRE

    Niggli, Urs; Slabe, Anamarija; Schmid, Otto; Halberg, Niels; Schlüter, Marco

    2009-01-01

    Ce dossier a pour objectif de montrer le chemin vers un programme de recherche européen en agriculture et alimentation biologiques qui permettra de faire face aux défis des vingt prochaines années.

  15. Fusillades scolaires : construction d’une catégorie et savoirs explicatifs d’une forme de violence juvénile

    OpenAIRE

    Paton, Nathalie

    2016-01-01

    Dans cet article, l’auteure présente une revue de la littérature, sous deux angles complémentaires, concernant la notion de school shooting, c’est-à-dire les fusillades commises au sein des établissements scolaires par des élèves. Elle examine d’abord la manière dont la notion a été forgée aux États-Unis au sein des débats publics en relation à une autre forme de violence juvénile, celle des gangs des milieux populaires des grandes villes, avant de constituer une forme de violence autonome, s...

  16. Clara BIERMANN : Les visages du candombe. Pratiques, création et savoir-faire chez les musiciens et les danseurs afro-uruguayens

    OpenAIRE

    2017-01-01

    Cette thèse propose une étude sur les musiciens et les danseurs afro-uruguayens considérés comme les spécialistes du candombe, le genre musico-chorégraphique emblématique de la culture afro-uruguayenne. Dans un contexte d’appropriation nationale du candombe, marqué par l’adoption de politiques patrimoniales qui s’appuient sur cet engouement pour lutter contre les discriminations raciales en Uruguay, ils revendiquent leur propriété sur ce genre. Cette recherche analyse les positionnements et ...

  17. L’anthropologue dans la réponse aux épidémies : science, savoir-faire ou placebo ?

    OpenAIRE

    Epelboin, Alain

    2010-01-01

    Alors que de plus en plus de chercheurs — juniors et seniors — s’interrogent sur la place de l’anthropologie dans la société, ainsi que sur les voies possibles de la professionnalisation, nous avons demandé à Alain Epelboin de nous faire part de sa réflexion en termes d’application de l’anthropologie médicale. En effet, sa participation à plusieurs missions pluridisciplinaires, à la demande de l’OMS, pour lutter contre des épidémies de fièvre hémorragique à virus Ebola et Marburg, fait assuré...

  18. Chronic recurrent multifocal osteomyelitis: how to suggest this diagnosis?; L`osteite chronique recurrente multifocale. Un diagnostic qu`il faut savoir evoquer

    Energy Technology Data Exchange (ETDEWEB)

    Saint-Martin, Ch. [UCL Cliniques Saint-Luc, Bruxelles (Belgium); Kurelovic, I.; Soler, C.; Geoffray, A. [Fondation Laval, 06 - Nice (France); Durckel, J. [Hopital Hautepierre, 67 - Strasbourg (France)

    1997-09-01

    Chronic recurrent multifocal osteomyelitis is a rare disorder that affects children and teenagers. Clinically, it is characterized by insidious onset of local swelling and pain in several metaphyses. A symmetric, recurrent and multifocal pattern is usual. Spinal involvement is possible. Inconstant association with a cutaneous affection (palmo-plantar pustulosis, acne fulminans, psoriasis), or less frequently with an inflammatory chronic gut disorder is described. Pathogenesis usually recognized is an enthesopathy. Enthesitis may progress to the osseous part of the enthese and produce an aseptic chronic osteomyelitis. Biopsy specimen with culture is certainly necessary to rule out bacterial osteomyelitis and bone tumor. It is particularly true when the bone lesion is isolated. Disease course is benign and self-limited. The clinical course is characterized by recurrences and remissions occurring for 6 to 10 years. Treatment based on non steroid anti-inflammatory drugs is usually effective. (authors). 17 refs.

  19. Stanovení adenosintrifosfátu a adenosindifosfátu v reálných vzorcích

    OpenAIRE

    Černá, Martina

    2013-01-01

    The aim of the diploma thesis was to find optimal conditions of high pressure liquid chromatography for the detection and quantification of two common nucleotides, namely adenosine diphosphate and adenosine triphosphate, as well as to perform an analysis of these in real life samples of citrus fruits and plant extracts. Further aim of the project was to determine the limits of detection and quantification of adenosine diphosphate and adenosine triphosphate under the optimized conditions and u...

  20. Confidence in and beliefs about first-year engineering student success : Case study from KU Leuven, TU Delft, and TU Graz

    NARCIS (Netherlands)

    de Laet, Tinne; Broos, Tom; van Staalduinen, J.P.; Ebner, Martin; Langie, G.; van Soom, Carolien; Schepers, Wim

    2017-01-01

    This paper explores the confidence starting first-year engineering students have in being successful in the first study year and which study-related behaviour they believe to be important to this end. Additionally, this paper studies which feedback these students would like to receive and compares

  1. La coherencia entre lo que saben de ti y lo que ven en tu rostro afecta a la valoración de tu personalidad

    Directory of Open Access Journals (Sweden)

    Fernando Gordillo

    2017-08-01

    Full Text Available La valoración que los demás hacen de nuestra personalidad tiene un importante efecto sobre las interacciones sociales. La emoción expresada juega un importante papel en esta valoración (p.ej., la sonrisa nos hace parecer más extrovertidos. Sin embargo, no le damos tanta importancia a la información previa que tiene el perceptor sobre nosotros ni a la coherencia entre esta información y la expresión percibida. En el presente artículo analizaremos cómo todos estos factores condicionan la impresión que causamos a los demás, muy importante, por ejemplo, cuando hacemos una entrevista de trabajo, cuando nos “evalúan” como posibles parejas, o cuando nos enfrentamos a un juicio.

  2. CEDEF

    International Development Research Centre (IDRC) Digital Library (Canada)

    Alejandra

    À qui devrais-je m'adresser si j'ai des questions au sujet de la demande ? Pour préserver le caractère équitable et objectif du processus de sélection, l'équipe du programme. CEDEF ne répondra à aucune question sur la substance de votre demande. La FAQ et l'appel en tant que tel devraient répondre à la plupart des ...

  3. Kinematická analýza posturálních změn v bipedálním stoji při aplikaci podnětu ze zevního prostředí a modifikaci vizuální scény u pacientů po plastice předního zkříženého vazu Kinematic analysis of postural changes in bipedal stance at application of stimulus from external environment and modifi cation of visual scene in patients with anterior cruciate ligament reconstruction

    Directory of Open Access Journals (Sweden)

    Miroslav Janura

    2007-01-01

    Full Text Available Tato studie se zabývá změnami postury při modifikované zrakové scéně a při aplikaci podnětu ze zevního prostředí u zdravých jedinců a u pacientů po plastice předního zkříženého vazu (LCA za nezměněné a modifi kované vizuální scény. Do vyšetřovaného souboru bylo zahrnuto 11 pacientů po plastice LCA a 14 zdravých jedinců. Modifi kace vizuální scény bylo dosaženo prostřednictvím speciálního optického systému Olympus – Eye trek FMD-700. Zevní podnět byl realizován pomocí nárazu letícího míče. K hodnocení posturálních změn jsme využili kinematickou analýzu. U pacientů po rekonstrukci LCA i u zdravých jedinců jsme nejvíce diferencí v jednotlivých způsobech provedení nalezli pro kinematické parametry na dolních končetinách a trupu. U obou skupin probandů jsme zaznamenali podobné tendence k posturálním změnám. Při porovnávání kinematických parametrů mezi skupinou pacientů a zdravých jedinců jsme nalezli rozdíly v poloze horních končetin. Pro dolní končetiny a trup (s výjimkou minimální velikosti úhlu bérec – stehno při modifi kované scéně s reálným podnětem nejsou rozdíly mezi oběma skupinami statisticky významné. Tears and rupture of the anterior cruciate ligament (ACL, which has an important function in knee joint stability, are very common and more so in sports. ACL injury can be managed in two ways. One alternative pertains to conservative therapy whereas the second variant is surgical intervention (reconstruction. The number of ACL reconstructions has risen recently. The purpose of this study was to analyze the postural changes in bipedal stance at application of a stimulus from external environment and the resultant modifi cation in the visual scene in patients with ACL reconstruction. The examined group consisted of 25 subjects – 11 patients with ACL reconstruction and 14 healthy adults. The external stimulus was realized by striking

  4. TU-C-HORIZONS-01: The Expanding Horizons Travel Grant Program: ePosters and Discussion

    Energy Technology Data Exchange (ETDEWEB)

    Siewerdsen, J [Johns Hopkins University, Baltimore, MD (United States); Jeraj, R [University of Wisconsin, Madison, WI (United States)

    2016-06-15

    The Expanding Horizons travel grant program provides opportunity for students and trainees to broaden the scope of scientific meetings they attend and gain insight from research outside traditional domains of medical physics. Through participation in such conferences, early-career researchers are introduced to new topics with relevance to medical physics research as a means to expand the scientific horizons of our discipline. This year, 21 Expanding Horizons travel grants were awarded, granting travel to 17 conferences, including: Radiomics, the World Molecular Imaging Society (WMIS), the 3D Printing Conference and Expo, the GPU Technology Conference, the SIAM Imaging Science Conference, the Human Brain Mapping Conference, the OSA Conference on Clinical and Translational Biophotonics, the Society for Neuroscience, the AACR Conference on Tumor Microenvironment, and the Conference on Knowledge Discovery and Data Mining. The Expanding Horizons electronic poster session gives a venue for AAPM conference attendees to meet and discuss with awardees, learn the hot topics and emerging research areas presented at these conferences, and understand the relevance to future medical physics research.

  5. O předmětu, metodě a zájmech naratologie

    Czech Academy of Sciences Publication Activity Database

    Jedličková, Alice

    2012-01-01

    Roč. 60, č. 6 (2012), s. 874-881 ISSN 0009-0468 R&D Projects: GA ČR GAP406/12/1711 Institutional support: RVO:68378068 Keywords : cognitive science * methodological pluralism * cognitive narratology * unnatural narratology * narrative poetics * postmodern fiction * experimental narrative * narrator * identity * subject * deviation Subject RIV: AJ - Letters, Mass-media, Audiovision

  6. TU-E-BRA-05: Reverse Geometry Imaging with MV Detector for Improved Image Resolution.

    Science.gov (United States)

    Ganguly, A; Abel, E; Sun, M; Fahrig, R; Virshup, G; Star-Lack, J

    2012-06-01

    Thick pixilated scintillators can offer significant improvements in quantum efficiency over phosphor screen megavoltage (MV) detectors. However spatial resolution can be compromised due to the spreading of light across pixels within septa. Of particular interest are the lower energy x-ray photons and associated light photons that produce higher image contrast but are stopped near the scintillator entrance surface. They suffer the most scattering in the scintillator prior to detection in the photodiodes. Reversing the detector geometry, so that the incident x-ray beam passes through the photodiode array into the scintillator, allows the light to scatter less prior to detection. This also reduces the Swank noise since now higher and lower energy x-ray photons tend to produce similar electronic signals. In this work, we present simulations and measurements of detector MTF for the conventional/forward and reverse geometries to demonstrate this phenomenon. A tabletop system consisting of a Varian CX1 1MeV linear accelerator and a modified Varian Paxscan4030 with the readout electronics moved away from the incident the beam was used. A special holder was used to press a 2.5W×5.0L×2.0Hcm 3 pixellated Cesium Iodide (CsI:Tl) scintillator array on to the detector glass. The CsI array had a pitch of 0.784mm with plastic septa between pixels and the photodiode array pitch was 0.192 mm. The MTF in the forward and reverse geometries was measured using a 0.5mm thick Tantalum slanted edge. Geant4-based Monte Carlo simulations were performed for comparison. The measured and simulated MTFs matched to within 3.4(±3.7)% in the forward and 4.4(±1.5)% in reverse geometries. The reverse geometry MTF was higher than the forward geometry MTF at all spatial frequencies and doubled to .25 at 0.3lp/mm. A novel method of improving the image resolution at MV energies was demonstrated. The improvements should be more pronounced with increased scintillator thickness. Funding support provided by NIH (grant number NIH R01 CA138426). © 2012 American Association of Physicists in Medicine.

  7. TU-E-BRA-07: Post-Operative Eye Plaque Imaging Using Tomotherapy MVCT.

    Science.gov (United States)

    Lamb, J; Chao, E; Kamrava, M; Demanes, J; McCannel, T; Low, D

    2012-06-01

    Intra-operative ultrasound is used to verify the positioning of episcleral eye plaques used to treat ocular melanoma. Ultrasound can be ambiguous because of image artifacts, and plaques may shift position after surgery. Ultrasound verification is particularly challenging for anterior tumors. Post-operative imaging could be used to trigger interventions that would prevent local treatment failure. We investigated if, and under what conditions, the Tomotherapy megavoltage computed tomography (MVCT) system could be used to perform post-implantation verification of eye plaque positioning. Plaques were placed on a preserved cow's eye, and imaged with the megavoltage CT of a Tomotherapy linear accelerator (Accuray, Sunnyvale, CA). The images were visually and quantitatively assessed to determine if they were of sufficient quality to verify tumor coverage and plaque tilt with respect to the sclera. We used the visibility of the lens as a proxy for visibility of a tumor. To test the utility of hypothetical higher beam current Tomotherapy images, we averaged sequential images of the same setup. The plaque, the lens of the eye, and the globe are visible in the images. The CNR of the lens with respect to the vitreous was 5.6 for a single image. For 10 images averaged, the CNR was 9.2. Estimated dose from a single image was 1.3 cGy (body CTDIvol); even 10 times this dose would be an acceptable image-guidance dose for radiotherapy patients. One limitation of the imaging procedure is the long scan time (up to 240 seconds), during which time any significant patient motion would lead to image artifacts. Human trials on eye plaque patients are planned. Tomotherapy MVCT imaging could be used to verify tumor coverage and plaque tilt after episcleral plaque implantation. Tumors should be visible in standard Tomotherapy images but higher beam current images would be preferred if available. © 2012 American Association of Physicists in Medicine.

  8. TU-E-BRA-02: A Method to Remove Support Arm Backscatter from EPID Images.

    Science.gov (United States)

    King, B; Greer, P

    2012-06-01

    To develop a method for removing the effect of support arm backscatter from Varian electronic portal imaging devices (EPIDs), improving the dosimetric abilities of the imager. A physical, kernel based model of the backscatter signal produced during an exposure was developed. The model parameters were determined through an optimization process, comparing measured images without arm backscatter (EPID removed from arm) to measured images that include arm backscatter. The backscatter model was used to develop a backscatter correction process that removes the support arm backscatter from measured EPID images. The correction process was tested by applying the method to measured images of 17 rectangular asymmetric fields and comparing the Result to off-arm images. The same process was repeated with 42 IMRT fields. The backscatter removal process was able to effectively remove the arm backscatter from all of the measured images and accurately predict the measured off-arm images. Comparing the corrected images to the measured off-arm images, the mean absolute difference at the centre of each rectangular field was 0.29% (standard deviation 0.18%). This is an improvement over the uncorrected images which gave a mean difference of 1.01% (standard deviation 0.73%). The largest discrepancy observed with the corrected images was 0.6%, compared to 2.8% for the uncorrected images. Comparing the corrected IMRT images to the measured off-arm images, an overall mean gamma value of 0.28 (standard deviation 0.04) was found using 2%, 2mm criteria. Comparison of the uncorrected images to the measured off-arm images resulted in an overall mean gamma of 0.40 (standard deviation 0.10). A method for accurately and reliably removing the effect of support arm backscatter from EPID images has been developed and extensively tested. The method can be applied to any measured EPID image and does not require any additional information about the exposure. © 2012 American Association of Physicists in Medicine.

  9. TU-F-CAMPUS-T-03: Enhancing the Tumor Specific Radiosensitization Using Molecular Targeted Gold Nanorods

    Energy Technology Data Exchange (ETDEWEB)

    Diagaradjane, P [M.D. Anderson Cancer Center, Houston, TX (United States); Deorukhkar, A; Sankaranarayanapillai, M; Singh, P [The UT MD Anderson Cancer Center, Houston, TX (United States); Manohar, N; Tailor, R; Cho, S [UT MD Anderson Cancer Center, Houston, TX (United States); Goodrich, G [Nanospectra Biosciences Inc, Houston, TX (United States); Krishnan, S [The University of Texas MD Anderson Cancer Center, Houston, TX (United States)

    2015-06-15

    Purpose: Gold nanoparticle (GNP) mediated radiosensitization has gained significant attention in recent years. However, the widely used passive targeting strategy requires high concentration of GNPs to induce the desired therapeutic effect, thus dampening the enthusiasm for clinical translation. The purpose of this study is to utilize a molecular targeting strategy to minimize the concentration of GNPs injected while simultaneously enhancing the tumor specific radiosensitization for an improved therapeutic outcome. Methods: Cetuximab (antibody specific to the epidermal growth factor receptor that is over-expressed in tumors) conjugated gold nanorods (cGNRs) was used for the tumor targeting. The binding affinity, internalization, and in vitro radiosensitization were evaluated using dark field microscopy, transmission electron microscopy, and clonogenic cell survival assay, respectively. In vivo biodistribution in tumor (HCT116-colorectal cancer cells) bearing mice were quantified using inductively coupled plasma mass spectrometry. In vivo radiosensitization potential was tested using 250-kVp x-rays and clinically relevant 6-MV radiation beams. Results: cGNRs displayed excellent cell-surface binding and internalization (∼31,000 vs 12,000/cell) when compared to unconjugated GNRs (pGNRs). In vitro, the dose enhancement factor at 10% survival (DEF10) was estimated as 1.06 and 1.17, respectively for both 250-kVp and 6-MV beams. In vivo biodistribution analysis revealed enhanced uptake of cGNRs in tumor (1.3 µg/g of tumor tissue), which is ∼1000-fold less than the reported values using passive targeting strategy. Nonetheless, significant radiosensitization was observed in vivo with cGNRs when compared to pGNRs, when irradiated with 250-kVp (tumor volume doubling time 35 days vs 25 days; p=0.002) and 6 MV (17 days vs 13 days; p=0.0052) beams. Conclusion: The enhanced radiosensitization effect observed with very low intratumoral concentrations of gold and megavoltage x-rays using the active targeting strategy holds promise for clinical translation of this strategy from a toxicity and cost-effectiveness perspective and could evolve as a paradigm-changing approach in the field of radiation oncology.

  10. TU-A-210-02: HIFU: Why Should a Radiation Oncology Physicist Pay Attention?

    Energy Technology Data Exchange (ETDEWEB)

    Schlesinger, D. [University of Virginia Health Systems (United States)

    2015-06-15

    High-intensity focused ultrasound (HIFU) has developed rapidly in recent years and is used frequently for clinical treatments in Asia and Europe with increasing clinical use and clinical trial activity in the US, making it an important medical technology with which the medical physics community must become familiar. Akin to medical devices that deliver treatments using ionizing radiation, HIFU relies on emitter geometry to non-invasively form a tight focus that can be used to affect diseased tissue while leaving healthy tissue intact. HIFU is unique in that it does not involve the use of ionizing radiation, it causes thermal necrosis in 100% of the treated tissue volume, and it has an immediate treatment effect. However, because it is an application of ultrasound energy, HIFU interacts strongly with tissue interfaces, which makes treatment planning challenging. In order to appreciate the advantages and disadvantages of HIFU as a thermal therapy, it is important to understand the underlying physics of ultrasound tissue interactions. The first lecture in the session will provide an overview of the physics of ultrasound wave propagation; the mechanism for the accumulation of heat in soft-tissue; image-guidance modalities including temperature monitoring; current clinical applications and commercial devices; active clinical trials; alternate mechanisms of action (future of FUS). The second part of the session will compare HIFU to existing ionization radiation techniques. The difficulties in defining a clear concept of absorbed dose for HIFU will be discussed. Some of the technical challenges that HIFU faces will be described, with an emphasis on how the experience of radiation oncology physicists could benefit the field. Learning Objectives: Describe the basic physics and biology of HIFU, including treatment delivery and image guidance techniques. Summarize existing and emerging clinical applications and manufacturers for HIFU. Understand that thermal ablation with HIFU is likely the first of several applications of the technology Learn about some similarities and differences between HIFU and ionizing radiation in terms of physics and biological effects. Learn about some of the technical challenges HIFU faces that might benefit from the experience of radiation oncology physicists including treatment planning improvements, quality assurance procedures, and treatment risk analysis. David Schlesinger receives research support from Elekta Instruments, AB. Matt Eames is an employee of the Focused Ultrasound Foundation which supports research and clinical trials. Dr. Eames conducts research which is supported by the Focused Ultrasound Foundation.

  11. TU-EF-207-02: Spectral Mammography Based on Photon Counting Detectors

    International Nuclear Information System (INIS)

    Molloi, S.

    2015-01-01

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation

  12. TU-EF-207-05: Dedicated Cone-beam Breast CT

    International Nuclear Information System (INIS)

    Vedantham, S.

    2015-01-01

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation

  13. TU-EF-207-04: Advances in Detector Technology for Breast Tomosynthesis

    International Nuclear Information System (INIS)

    Zhao, W.

    2015-01-01

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation

  14. TU-CD-303-00: In Memoriam of Warren Sinclair: Physics Applications for New Radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    The Medical Physics and Radiation Protection communities lost one of their true pioneers in May, 2014 with the passing of Warren K. Sinclair, Ph.D. He received his Doctorate in Physics at the University of London, U.K. He was a fellow of the Institute of Physics and a Certified Health Physicist. After a number of posts at Hospitals and Universities in the U.K. and New Zealand, he became the Head, Physics Department at the M.D. Anderson Hospital, Houston, TX. He held a number of academic physics positions with the University of Texas, Austin at the main campus and at the Postgraduate School of Medicine, Houston. He later served as a Senior Biophysicist, Division Director, and then Associate Laboratory Director for Biomedical Division Director, and then Associate Laboratory Director for Biomedical and Environmental Research at the Argonne National Laboratory, IL. He had additional academic appointments at the University of California, Berkeley; Northern Illinois University; the University of Illinois (Chicago Circle Campus); and the University of Chicago. Warren was a charter member of the AAPM and a leader in many communities: President of the AAPM from 1960 to 1961 and the Journal Editor from 1964 to 1969, the 2nd President of the NCRP from 1977 to 1991, and the President of the Radiation Research Society from 1978 to 1979. His many awards included the William D. Coolidge Award in 1986. Even this barely scratches the surface of the many other organizations he served with and influenced including the ICRP, IOP, RSNA, SNM, and UNSCEAR. His research interests resulted in publications from 1948 to the 1990s in many aspects (physical and biological) of radiotherapy and the effects of ionizing radiation in general, leading to early definitions of RBE values for megavoltage radiotherapy as well as contributing to the development of the modern framework for radiation protection worldwide. Warren was not a retiring person and even after moving to NCRP President Emeritus status continued to provide advice and comments on publications and to mentor others until the time of his passing. Sadly, Warren’s long-time wife Joy passed away in December, 2014 but he is survived by his son Bruce and daughter Roslyn, 2 grandchildren and 4 great-grandchildren.

  15. TU-CD-303-01: Memorial to Warren Sinclair - Memorial Lecturer

    Energy Technology Data Exchange (ETDEWEB)

    Grissom, M [MPG--HP Inc, Riverside, CA (United States)

    2015-06-15

    The Medical Physics and Radiation Protection communities lost one of their true pioneers in May, 2014 with the passing of Warren K. Sinclair, Ph.D. He received his Doctorate in Physics at the University of London, U.K. He was a fellow of the Institute of Physics and a Certified Health Physicist. After a number of posts at Hospitals and Universities in the U.K. and New Zealand, he became the Head, Physics Department at the M.D. Anderson Hospital, Houston, TX. He held a number of academic physics positions with the University of Texas, Austin at the main campus and at the Postgraduate School of Medicine, Houston. He later served as a Senior Biophysicist, Division Director, and then Associate Laboratory Director for Biomedical Division Director, and then Associate Laboratory Director for Biomedical and Environmental Research at the Argonne National Laboratory, IL. He had additional academic appointments at the University of California, Berkeley; Northern Illinois University; the University of Illinois (Chicago Circle Campus); and the University of Chicago. Warren was a charter member of the AAPM and a leader in many communities: President of the AAPM from 1960 to 1961 and the Journal Editor from 1964 to 1969, the 2nd President of the NCRP from 1977 to 1991, and the President of the Radiation Research Society from 1978 to 1979. His many awards included the William D. Coolidge Award in 1986. Even this barely scratches the surface of the many other organizations he served with and influenced including the ICRP, IOP, RSNA, SNM, and UNSCEAR. His research interests resulted in publications from 1948 to the 1990s in many aspects (physical and biological) of radiotherapy and the effects of ionizing radiation in general, leading to early definitions of RBE values for megavoltage radiotherapy as well as contributing to the development of the modern framework for radiation protection worldwide. Warren was not a retiring person and even after moving to NCRP President Emeritus status continued to provide advice and comments on publications and to mentor others until the time of his passing. Sadly, Warren’s long-time wife Joy passed away in December, 2014 but he is survived by his son Bruce and daughter Roslyn, 2 grandchildren and 4 great-grandchildren.

  16. TU-CD-213-00: Administrative Aspects of Medical Physics

    International Nuclear Information System (INIS)

    2015-01-01

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration

  17. TU-CD-213-03: Communication, Negotiation, and Persuasion: Approaches for Better Results

    Energy Technology Data Exchange (ETDEWEB)

    Wells, M. [Piedmont Cancer (United States)

    2015-06-15

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration.

  18. TU-CD-213-02: Communication, Negotiation, and Persuasion: Approaches for Better Results

    Energy Technology Data Exchange (ETDEWEB)

    Clements, J. [Kaiser Permanente (United States)

    2015-06-15

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration.

  19. TU-CD-213-01: Communication, Negotiation, and Persuasion: Approaches for Better Results

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, J. [MD Anderson Cancer Center (United States)

    2015-06-15

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration.

  20. TU-CD-213-03: Communication, Negotiation, and Persuasion: Approaches for Better Results

    International Nuclear Information System (INIS)

    Wells, M.

    2015-01-01

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration

  1. TU-CD-213-00: Administrative Aspects of Medical Physics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration.

  2. TU-CD-213-02: Communication, Negotiation, and Persuasion: Approaches for Better Results

    International Nuclear Information System (INIS)

    Clements, J.

    2015-01-01

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration

  3. TU-CD-213-01: Communication, Negotiation, and Persuasion: Approaches for Better Results

    International Nuclear Information System (INIS)

    Johnson, J.

    2015-01-01

    As part of the AAPM’s Scope of Practice, medical physicists are expected to collaborate effectively with practioners and allied health care providers. Interpersonal skills such as communication, negotiation and persuasion are vital for successful collaboration to achieve shared goals. This session will provide some theoretical background of these interpersonal skills as well as specific techniques and practical tools to influence others. Applications of these interpersonal skills for administrative and human resource management purposes vital to medical physicists will be shared. Session attendees will gain knowledge and tools to help them effectively collaborate with administrative and physician leaders in areas such as capital and human resource selection, prioritization, and implementation. Participants will hear methods of how to articulate their goals and to understand the goals of administration, helping ensure alignment of purpose. Session speakers will present one of the topics: equipment selection, budget creation, contracts, and program-related policy development. Specifics may include designing a business case in language that administrators understand, calculating the prioritization of budget requests, and influencing policies for safe and effective care. Human resource topics may include staffing justification, recruitment for fit, employment contracts, and benefits. Speakers will provide examples in both radiation therapy and diagnostic imaging departments and will share experiences and outcomes of their approaches for better results. Learning Objectives: After this course attendees will be better able to Understand the shared goal between administrative and physicist leadership. Articulate the “why” of the technical or human resource need. Utilize communication, negotiation and persuasion tools to improve collaboration

  4. Turbulent drag reduction by nonplanar surfaces - A survey on the research at TU/DLR Berlin

    Science.gov (United States)

    Bechert, D. W.; Bartenwerfer, M.; Hoppe, G.

    The use of riblets for drag reduction is examined theoretically. For various riblet shapes, the anisotropic properties of the viscous flow over the riblets are determined. The results obtained can be used for riblet optimization and as input data for computer simulations of the complete turbulent flow field. Attention is also given to other concepts, such as hypothetical mechanisms derived from observations of the shark skin. The experimental facilities that would be required to test these new concepts are discussed.

  5. TU-AB-204-00: CDRH/FDA Regulatory Processes and Device Science Activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-15

    The responsibilities of the Food and Drug Administration (FDA) have increased since the inception of the Food and Drugs Act in 1906. Medical devices first came under comprehensive regulation with the passage of the 1938 Food, Drug, and Cosmetic Act. In 1971 FDA also took on the responsibility for consumer protection against unnecessary exposure to radiation-emitting devices for home and occupational use. However it was not until 1976, under the Medical Device Regulation Act, that the FDA was responsible for the safety and effectiveness of medical devices. This session will be presented by the Division of Radiological Health (DRH) and the Division of Imaging, Diagnostics, and Software Reliability (DIDSR) from the Center for Devices and Radiological Health (CDRH) at the FDA. The symposium will discuss on how we protect and promote public health with a focus on medical physics applications organized into four areas: pre-market device review, post-market surveillance, device compliance, current regulatory research efforts and partnerships with other organizations. The pre-market session will summarize the pathways FDA uses to regulate the investigational use and commercialization of diagnostic imaging and radiation therapy medical devices in the US, highlighting resources available to assist investigators and manufacturers. The post-market session will explain the post-market surveillance and compliance activities FDA performs to monitor the safety and effectiveness of devices on the market. The third session will describe research efforts that support the regulatory mission of the Agency. An overview of our regulatory research portfolio to advance our understanding of medical physics and imaging technologies and approaches to their evaluation will be discussed. Lastly, mechanisms that FDA uses to seek public input and promote collaborations with professional, government, and international organizations, such as AAPM, International Electrotechnical Commission (IEC), Image Gently, and the Quantitative Imaging Biomarkers Alliance (QIBA) among others, to fulfill FDA’s mission will be discussed. Learning Objectives: Understand FDA’s pre-market and post-market review processes for medical devices Understand FDA’s current regulatory research activities in the areas of medical physics and imaging products Understand how being involved with AAPM and other organizations can also help to promote innovative, safe and effective medical devices J. Delfino, nothing to disclose.

  6. TU-AB-204-02: Device Adverse Events and Compliance

    Energy Technology Data Exchange (ETDEWEB)

    Gonzales, S. [Food & Drug Administration (United States)

    2016-06-15

    The responsibilities of the Food and Drug Administration (FDA) have increased since the inception of the Food and Drugs Act in 1906. Medical devices first came under comprehensive regulation with the passage of the 1938 Food, Drug, and Cosmetic Act. In 1971 FDA also took on the responsibility for consumer protection against unnecessary exposure to radiation-emitting devices for home and occupational use. However it was not until 1976, under the Medical Device Regulation Act, that the FDA was responsible for the safety and effectiveness of medical devices. This session will be presented by the Division of Radiological Health (DRH) and the Division of Imaging, Diagnostics, and Software Reliability (DIDSR) from the Center for Devices and Radiological Health (CDRH) at the FDA. The symposium will discuss on how we protect and promote public health with a focus on medical physics applications organized into four areas: pre-market device review, post-market surveillance, device compliance, current regulatory research efforts and partnerships with other organizations. The pre-market session will summarize the pathways FDA uses to regulate the investigational use and commercialization of diagnostic imaging and radiation therapy medical devices in the US, highlighting resources available to assist investigators and manufacturers. The post-market session will explain the post-market surveillance and compliance activities FDA performs to monitor the safety and effectiveness of devices on the market. The third session will describe research efforts that support the regulatory mission of the Agency. An overview of our regulatory research portfolio to advance our understanding of medical physics and imaging technologies and approaches to their evaluation will be discussed. Lastly, mechanisms that FDA uses to seek public input and promote collaborations with professional, government, and international organizations, such as AAPM, International Electrotechnical Commission (IEC), Image Gently, and the Quantitative Imaging Biomarkers Alliance (QIBA) among others, to fulfill FDA’s mission will be discussed. Learning Objectives: Understand FDA’s pre-market and post-market review processes for medical devices Understand FDA’s current regulatory research activities in the areas of medical physics and imaging products Understand how being involved with AAPM and other organizations can also help to promote innovative, safe and effective medical devices J. Delfino, nothing to disclose.

  7. TU-AB-204-03: Research Activities in Medical Physics

    Energy Technology Data Exchange (ETDEWEB)

    Badano, A. [Food & Drug Administration (United States)

    2016-06-15

    The responsibilities of the Food and Drug Administration (FDA) have increased since the inception of the Food and Drugs Act in 1906. Medical devices first came under comprehensive regulation with the passage of the 1938 Food, Drug, and Cosmetic Act. In 1971 FDA also took on the responsibility for consumer protection against unnecessary exposure to radiation-emitting devices for home and occupational use. However it was not until 1976, under the Medical Device Regulation Act, that the FDA was responsible for the safety and effectiveness of medical devices. This session will be presented by the Division of Radiological Health (DRH) and the Division of Imaging, Diagnostics, and Software Reliability (DIDSR) from the Center for Devices and Radiological Health (CDRH) at the FDA. The symposium will discuss on how we protect and promote public health with a focus on medical physics applications organized into four areas: pre-market device review, post-market surveillance, device compliance, current regulatory research efforts and partnerships with other organizations. The pre-market session will summarize the pathways FDA uses to regulate the investigational use and commercialization of diagnostic imaging and radiation therapy medical devices in the US, highlighting resources available to assist investigators and manufacturers. The post-market session will explain the post-market surveillance and compliance activities FDA performs to monitor the safety and effectiveness of devices on the market. The third session will describe research efforts that support the regulatory mission of the Agency. An overview of our regulatory research portfolio to advance our understanding of medical physics and imaging technologies and approaches to their evaluation will be discussed. Lastly, mechanisms that FDA uses to seek public input and promote collaborations with professional, government, and international organizations, such as AAPM, International Electrotechnical Commission (IEC), Image Gently, and the Quantitative Imaging Biomarkers Alliance (QIBA) among others, to fulfill FDA’s mission will be discussed. Learning Objectives: Understand FDA’s pre-market and post-market review processes for medical devices Understand FDA’s current regulatory research activities in the areas of medical physics and imaging products Understand how being involved with AAPM and other organizations can also help to promote innovative, safe and effective medical devices J. Delfino, nothing to disclose.

  8. TU-H-206-02: Novel Linearly-Filled Derenzo PET Phantom Design

    International Nuclear Information System (INIS)

    Graves, S; Cox, B; Valdovinos, H; Jeffery, J; Eliceiri, K; Barnhart, T; Nickles, R; Farhoud, M

    2016-01-01

    Purpose: To design a linearly-filled Derenzo positron emission tomography (PET) phantom, eliminating the extraneous radioisotope volumes in a conventional reservoir-type design. This activity reduction combined with the elimination of bubbles in smaller phantom channels would significantly reduce personnel dose, radioisotope cost, and would improve image quality by reducing out-of-slice activity scatter. Methods: A computer-aided design (CAD) was created of a modular Derenzo phantom consisting of three phantom layers with gaskets between the layers. The central piece contains the active pattern volume and channels connecting adjacent rods in a serpentine pattern. The two end-pieces contained an inlet and an outlet for filling purposes. Phantom prototypes were 3D printed on a Viper Si2 stereolithography machine. The two gaskets were fabricated from silicon sheets using a PLS 6.75 laser cutter. Phantoms were held together by pass-through glass-filled nylon bolts and nuts. Phantoms were filled with 52 Mn, 64 Cu, 74 Br, and 124 I for testing, and were imaged on a Siemens Inveon MicroPET scanner. Results: Four phantom prototypes were constructed using male Leur Lock fittings for inlet/outlet ports. 3D printed layers were sanded to ensure proper coupling to the silicon gaskets. The filling volume for each prototype was approximately 2.4 mL. The filling process was found to be rapid, leak-tight, and with minimal back-pressure. PET images were reconstructed by OSEM3D, and axial slices along the phantom pattern length were averaged to provide final images. Image distortion was isotope dependent with 52 Mn and 64 Cu having the least distortion and 124 I having the most distortion. Conclusion: These results indicate that the linearlyfilled Derenzo design improves on conventional reservoir-type designs by eliminating potential bubbles in small channels and by reducing activity level, radioisotope volume, radioisotope cost, personnel dose, filling time, and out-of-slice activity scatter The method described in this abstract has been filed as a patent application to the US Patent and Trade Office by the Wisconsin Alumni Research Foundation (WARF).

  9. TU-C-201-02: Clinical Implementation of HDR: Afterloader and Applicator Selection

    Energy Technology Data Exchange (ETDEWEB)

    Esthappan, J. [Washington University School of Medicine (United States)

    2015-06-15

    Recent use of HDR has increased while planning has become more complex often necessitating 3D image-based planning. While many guidelines for the use of HDR exist, they have not kept pace with the increased complexity of 3D image-based planning. Furthermore, no comprehensive document exists to describe the wide variety of current HDR clinical indications. This educational session aims to summarize existing national and international guidelines for the safe implementation of an HDR program. A summary of HDR afterloaders available on the market and their existing applicators will be provided, with guidance on how to select the best fit for each institution’s needs. Finally, the use of checklists will be discussed as a means to implement a safe and efficient HDR program and as a method by which to verify the quality of an existing HDR program. This session will provide the perspective of expert HDR physicists as well as the perspective of a new HDR user. Learning Objectives: Summarize national and international safety and staffing guidelines for HDR implementation Discuss the process of afterloader and applicator selection for gynecologic, prostate, breast, interstitial, surface treatments Learn about the use of an audit checklist tool to measure of quality control of a new or existing HDR program Describe the evolving use of checklists within an HDR program.

  10. TU-C-201-00: Clinical Implementation of HDR Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    Recent use of HDR has increased while planning has become more complex often necessitating 3D image-based planning. While many guidelines for the use of HDR exist, they have not kept pace with the increased complexity of 3D image-based planning. Furthermore, no comprehensive document exists to describe the wide variety of current HDR clinical indications. This educational session aims to summarize existing national and international guidelines for the safe implementation of an HDR program. A summary of HDR afterloaders available on the market and their existing applicators will be provided, with guidance on how to select the best fit for each institution’s needs. Finally, the use of checklists will be discussed as a means to implement a safe and efficient HDR program and as a method by which to verify the quality of an existing HDR program. This session will provide the perspective of expert HDR physicists as well as the perspective of a new HDR user. Learning Objectives: Summarize national and international safety and staffing guidelines for HDR implementation Discuss the process of afterloader and applicator selection for gynecologic, prostate, breast, interstitial, surface treatments Learn about the use of an audit checklist tool to measure of quality control of a new or existing HDR program Describe the evolving use of checklists within an HDR program.

  11. Radiochemical research and education program at the TU in Ho-Chi-Minh City

    International Nuclear Information System (INIS)

    Ngo Manh Thang

    2016-01-01

    In the first part of this presentation a review of studying programmes at the Ho-Chi-Minh City University of Technology as well as international co-operation is discussed. In the second part the results of gamma radiation induced radiolysis of sulfamethoxazole aqueous solutions are presented.

  12. TU-PIS-Exhibit Hall-01: CT Dose Optimization Technologies II

    International Nuclear Information System (INIS)

    Driesser, I; Angel, E

    2014-01-01

    Partners in Solutions is an exciting new program in which AAPM partners with our vendors to present practical “hands-on” information about the equipment and software systems that we use in our clinics. The imaging topic this year is CT scanner dose optimization capabilities. Note that the sessions are being held in a special purpose room built on the Exhibit Hall Floor, to encourage further interaction with the vendors. Siemens‘ Commitment to the Right Dose in Computed Tomography Presentation Time: 11:15 - 11:45 AM Providing sustainable clinical results at highest patient safety: This is the challenge in medical imaging. Especially for Computed Tomography this means applying not simply the lowest, but the right dose for sound diagnostic imaging. Consequently, Siemens is committed to deliver the right dose in CT. In order to reduce radiation to the right dose, the first step is to provide the right dose technology. Through decades of research and development in CT imaging, Siemens CT has constantly introduced new ideas leading to a comprehensive portfolio of unique CARE technologies to deliver the right dose. For example automated kV adjustment based on patient size and the clinical question with CARE kV and three generations of iterative reconstruction. Based on the right dose technology, the next step is to actually scan at the right dose. For this, it is key to know the right dose targets for every examination. Siemens continuously involves CT experts to push developments further and outline how users can best adapt their procedures to the right dose. For users to know whether they met the right dose targets, it is therefore important to understand and monitor the actual absolute dose values. All scanners are delivered with defined default protocols which automatically use the available right dose technologies. Finally, to deliver the right dose not just in singular cases, but ideally to patients everywhere, organizations need then to manage dose across their institutions. Here Siemens offers the right dose management tools for administrations to analyze and document dose, to train their clinical staff and to continuously optimize the application of the right dose in clinical routine. Siemens CT is not only adhering to the ALARA principle, but is inspired by it. With CARE Right Siemens show their commitment to the right dose in CT. Toshiba Aquilion CT Dose Management Tools Presentation Time: 11:45 - 12:15 PM A practical review of Toshiba’s CT dose management technologies from the physicist’s perspective. This presentation will include an overview of Toshiba’s CT dose reduction technologies and dose safeguards. Content will include answers to frequently asked questions relating to dose management, dose tracking, CTDI measurement, ACR accreditation, ACR QC, and protocol review on Toshiba CT systems. Specific topics will include the following: Toshiba’s mechanism of tube current modulation; Exposure record format and interpretation of the values; Dose reporting and dose safeguard tools; Use of AIDR 3D iterative reconstruction; The configuration of task specific image quality target and its integration with AIDR 3D; Tips for scanning the ACR phantom with wide beam geometry; Measuring CTDI for wide beam geometry; Discussion of daily QC procedures and specifications; Tips for annual QC evaluation; Protocol management tools

  13. TU-B-16A-01: To Which Journal Should I Submit My Paper

    International Nuclear Information System (INIS)

    Williamson, J; Mills, M; Klein, E; Pawlicki, T

    2014-01-01

    Research papers authored by Medical Physicists address a large spectrum of oncologic, imaging, or basic research problems; exploit a wide range of physical and engineering methodologies; and often describe the efforts of a multidisciplinary research team. Given the large number (about 100) competing journals accepting medical physics articles, it may not be clear to an individual author which journal is the best venue for disseminating their work to the scientific community. Relevant factors usually include the Journal’s audience and scientific impact, but also such factors as perceived acceptance rate, interest in their topic, and quality of service. The purpose of this symposium is to provide the medical physics community with an overview of scope, review processes, and article guidelines for the following journals: Medical Physics, International Journal of Radiation Biology and Physics, Journal of Applied Clinical Medical Physics, and Practical Radiation Oncology. The senior editors for each journal will provide details as to the journals review process, for example: single blind versus double blind reviews; the hierarchy of the review process in terms of editorial board structure; the reality of acceptance, in terms of acceptance rate; and the types of research the journal prefers to publish. The goal is to provide for authors guidance before they begin to write their papers, not only for proper formatting, but also that the readership is appropriate for the particular paper, hopefully increasing the likelihood of publication. Learning Objectives: To review each Journal’s submission and review process Guidance as to how to increase chances of acceptance To help decipher which journal is appropriate for a given work

  14. TU-EF-210-00: Therapeutic Strategies and Image Guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    The use of therapeutic ultrasound to provide targeted therapy is an active research area that has a broad application scope. The invited talks in this session will address currently implemented strategies and protocols for both hyperthermia and ablation applications using therapeutic ultrasound. The role of both ultrasound and MRI in the monitoring and assessment of these therapies will be explored in both pre-clinical and clinical applications. Katherine Ferrara: High Intensity Focused Ultrasound, Drug Delivery, and Immunotherapy Rajiv Chopra: Translating Localized Doxorubicin Delivery to Pediatric Oncology using MRI-guided HIFU Elisa Konofagou: Real-time Ablation Monitoring and Lesion Quantification using Harmonic Motion Imaging Keyvan Farahani: AAPM Task Groups in Interventional Ultrasound Imaging and Therapy Learning Objectives: Understand the role of ultrasound in localized drug delivery and the effects of immunotherapy when used in conjunction with ultrasound therapy. Understand potential targeted drug delivery clinical applications including pediatric oncology. Understand the technical requirements for performing targeted drug delivery. Understand how radiation-force approaches can be used to both monitor and assess high intensity focused ultrasound ablation therapy. Understand the role of AAPM task groups in ultrasound imaging and therapies. Chopra: Funding from Cancer Prevention and Research Initiative of Texas (CPRIT), Award R1308 Evelyn and M.R. Hudson Foundation; Research Support from Research Contract with Philips Healthcare; COI are Co-founder of FUS Instruments Inc Ferrara: Supported by NIH, UCDavis and California (CIRM and BHCE) Farahani: In-kind research support from Philips Healthcare.

  15. TU-EF-210-01: HIFU, Drug Delivery, and Immunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ferrara, K. [University of California - Davis (United States)

    2015-06-15

    The use of therapeutic ultrasound to provide targeted therapy is an active research area that has a broad application scope. The invited talks in this session will address currently implemented strategies and protocols for both hyperthermia and ablation applications using therapeutic ultrasound. The role of both ultrasound and MRI in the monitoring and assessment of these therapies will be explored in both pre-clinical and clinical applications. Katherine Ferrara: High Intensity Focused Ultrasound, Drug Delivery, and Immunotherapy Rajiv Chopra: Translating Localized Doxorubicin Delivery to Pediatric Oncology using MRI-guided HIFU Elisa Konofagou: Real-time Ablation Monitoring and Lesion Quantification using Harmonic Motion Imaging Keyvan Farahani: AAPM Task Groups in Interventional Ultrasound Imaging and Therapy Learning Objectives: Understand the role of ultrasound in localized drug delivery and the effects of immunotherapy when used in conjunction with ultrasound therapy. Understand potential targeted drug delivery clinical applications including pediatric oncology. Understand the technical requirements for performing targeted drug delivery. Understand how radiation-force approaches can be used to both monitor and assess high intensity focused ultrasound ablation therapy. Understand the role of AAPM task groups in ultrasound imaging and therapies. Chopra: Funding from Cancer Prevention and Research Initiative of Texas (CPRIT), Award R1308 Evelyn and M.R. Hudson Foundation; Research Support from Research Contract with Philips Healthcare; COI are Co-founder of FUS Instruments Inc Ferrara: Supported by NIH, UCDavis and California (CIRM and BHCE) Farahani: In-kind research support from Philips Healthcare.

  16. TU-G-210-00: Treatment Planning Strategies, Modeling, Control

    International Nuclear Information System (INIS)

    2015-01-01

    Modeling can play a vital role in predicting, optimizing and analyzing the results of therapeutic ultrasound treatments. Simulating the propagating acoustic beam in various targeted regions of the body allows for the prediction of the resulting power deposition and temperature profiles. In this session we will apply various modeling approaches to breast, abdominal organ and brain treatments. Of particular interest is the effectiveness of procedures for correcting for phase aberrations caused by intervening irregular tissues, such as the skull in transcranial applications or inhomogeneous breast tissues. Also described are methods to compensate for motion in targeted abdominal organs such as the liver or kidney. Douglas Christensen – Modeling for Breast and Brain HIFU Treatment Planning Tobias Preusser – TRANS-FUSIMO – An Integrative Approach to Model-Based Treatment Planning of Liver FUS Tobias Preusser – TRANS-FUSIMO – An Integrative Approach to Model-Based Treatment Planning of Liver FUS Learning Objectives: Understand the role of acoustic beam modeling for predicting the effectiveness of therapeutic ultrasound treatments. Apply acoustic modeling to specific breast, liver, kidney and transcranial anatomies. Determine how to obtain appropriate acoustic modeling parameters from clinical images. Understand the separate role of absorption and scattering in energy delivery to tissues. See how organ motion can be compensated for in ultrasound therapies. Compare simulated data with clinical temperature measurements in transcranial applications. Supported by NIH R01 HL172787 and R01 EB013433 (DC); EU Seventh Framework Programme (FP7/2007-2013) under 270186 (FUSIMO) and 611889 (TRANS-FUSIMO)(TP); and P01 CA159992, GE, FUSF and InSightec (UV)

  17. TU-EF-210-04: AAPM Task Groups in Interventional Ultrasound Imaging and Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Farahani, K. [National Cancer Institute (United States)

    2015-06-15

    The use of therapeutic ultrasound to provide targeted therapy is an active research area that has a broad application scope. The invited talks in this session will address currently implemented strategies and protocols for both hyperthermia and ablation applications using therapeutic ultrasound. The role of both ultrasound and MRI in the monitoring and assessment of these therapies will be explored in both pre-clinical and clinical applications. Katherine Ferrara: High Intensity Focused Ultrasound, Drug Delivery, and Immunotherapy Rajiv Chopra: Translating Localized Doxorubicin Delivery to Pediatric Oncology using MRI-guided HIFU Elisa Konofagou: Real-time Ablation Monitoring and Lesion Quantification using Harmonic Motion Imaging Keyvan Farahani: AAPM Task Groups in Interventional Ultrasound Imaging and Therapy Learning Objectives: Understand the role of ultrasound in localized drug delivery and the effects of immunotherapy when used in conjunction with ultrasound therapy. Understand potential targeted drug delivery clinical applications including pediatric oncology. Understand the technical requirements for performing targeted drug delivery. Understand how radiation-force approaches can be used to both monitor and assess high intensity focused ultrasound ablation therapy. Understand the role of AAPM task groups in ultrasound imaging and therapies. Chopra: Funding from Cancer Prevention and Research Initiative of Texas (CPRIT), Award R1308 Evelyn and M.R. Hudson Foundation; Research Support from Research Contract with Philips Healthcare; COI are Co-founder of FUS Instruments Inc Ferrara: Supported by NIH, UCDavis and California (CIRM and BHCE) Farahani: In-kind research support from Philips Healthcare.

  18. TU-EF-210-00: Therapeutic Strategies and Image Guidance

    International Nuclear Information System (INIS)

    2015-01-01

    The use of therapeutic ultrasound to provide targeted therapy is an active research area that has a broad application scope. The invited talks in this session will address currently implemented strategies and protocols for both hyperthermia and ablation applications using therapeutic ultrasound. The role of both ultrasound and MRI in the monitoring and assessment of these therapies will be explored in both pre-clinical and clinical applications. Katherine Ferrara: High Intensity Focused Ultrasound, Drug Delivery, and Immunotherapy Rajiv Chopra: Translating Localized Doxorubicin Delivery to Pediatric Oncology using MRI-guided HIFU Elisa Konofagou: Real-time Ablation Monitoring and Lesion Quantification using Harmonic Motion Imaging Keyvan Farahani: AAPM Task Groups in Interventional Ultrasound Imaging and Therapy Learning Objectives: Understand the role of ultrasound in localized drug delivery and the effects of immunotherapy when used in conjunction with ultrasound therapy. Understand potential targeted drug delivery clinical applications including pediatric oncology. Understand the technical requirements for performing targeted drug delivery. Understand how radiation-force approaches can be used to both monitor and assess high intensity focused ultrasound ablation therapy. Understand the role of AAPM task groups in ultrasound imaging and therapies. Chopra: Funding from Cancer Prevention and Research Initiative of Texas (CPRIT), Award R1308 Evelyn and M.R. Hudson Foundation; Research Support from Research Contract with Philips Healthcare; COI are Co-founder of FUS Instruments Inc Ferrara: Supported by NIH, UCDavis and California (CIRM and BHCE) Farahani: In-kind research support from Philips Healthcare

  19. TU-G-210-01: Modeling for Breast and Brain HIFU Treatment Planning

    International Nuclear Information System (INIS)

    Christensen, D.

    2015-01-01

    Modeling can play a vital role in predicting, optimizing and analyzing the results of therapeutic ultrasound treatments. Simulating the propagating acoustic beam in various targeted regions of the body allows for the prediction of the resulting power deposition and temperature profiles. In this session we will apply various modeling approaches to breast, abdominal organ and brain treatments. Of particular interest is the effectiveness of procedures for correcting for phase aberrations caused by intervening irregular tissues, such as the skull in transcranial applications or inhomogeneous breast tissues. Also described are methods to compensate for motion in targeted abdominal organs such as the liver or kidney. Douglas Christensen – Modeling for Breast and Brain HIFU Treatment Planning Tobias Preusser – TRANS-FUSIMO – An Integrative Approach to Model-Based Treatment Planning of Liver FUS Tobias Preusser – TRANS-FUSIMO – An Integrative Approach to Model-Based Treatment Planning of Liver FUS Learning Objectives: Understand the role of acoustic beam modeling for predicting the effectiveness of therapeutic ultrasound treatments. Apply acoustic modeling to specific breast, liver, kidney and transcranial anatomies. Determine how to obtain appropriate acoustic modeling parameters from clinical images. Understand the separate role of absorption and scattering in energy delivery to tissues. See how organ motion can be compensated for in ultrasound therapies. Compare simulated data with clinical temperature measurements in transcranial applications. Supported by NIH R01 HL172787 and R01 EB013433 (DC); EU Seventh Framework Programme (FP7/2007-2013) under 270186 (FUSIMO) and 611889 (TRANS-FUSIMO)(TP); and P01 CA159992, GE, FUSF and InSightec (UV)

  20. TU-AB-204-02: Advances in C-Arm CBCT for Cardiac Interventions

    International Nuclear Information System (INIS)

    Fahrig, R.

    2015-01-01

    This symposium highlights advanced cone-beam CT (CBCT) technologies in four areas of emerging application in diagnostic imaging and image-guided interventions. Each area includes research that extends the spatial, temporal, and/or contrast resolution characteristics of CBCT beyond conventional limits through advances in scanner technology, acquisition protocols, and 3D image reconstruction techniques. Dr. G. Chen (University of Wisconsin) will present on the topic: Advances in C-arm CBCT for Brain Perfusion Imaging. Stroke is a leading cause of death and disability, and a fraction of people having an acute ischemic stroke are suitable candidates for endovascular therapy. Critical factors that affect both the likelihood of successful revascularization and good clinical outcome are: 1) the time between stroke onset and revascularization; and 2) the ability to distinguish patients who have a small volume of irreversibly injured brain (ischemic core) and a large volume of ischemic but salvageable brain (penumbra) from patients with a large ischemic core and little or no penumbra. Therefore, “time is brain” in the care of the stroke patients. C-arm CBCT systems widely available in angiography suites have the potential to generate non-contrast-enhanced CBCT images to exclude the presence of hemorrhage, time-resolved CBCT angiography to evaluate the site of occlusion and collaterals, and CBCT perfusion parametric images to assess the extent of the ischemic core and penumbra, thereby fulfilling the imaging requirements of a “one-stop-shop” in the angiography suite to reduce the time between onset and revascularization therapy. The challenges and opportunities to advance CBCT technology to fully enable the one-stop-shop C-arm CBCT platform for brain imaging will be discussed. Dr. R. Fahrig (Stanford University) will present on the topic: Advances in C-arm CBCT for Cardiac Interventions. With the goal of providing functional information during cardiac interventions, significant effort has been expended to improve the quantitative accuracy of C-arm CBCT reconstructions. The challenge is to improve image quality while providing very short turnaround between data acquisition and volume data visualization. Corrections for x-ray scatter, view aliasing and patient motion that require no more than 2 iterations keep processing time short while reducing artifact. Fast, multi-sweep acquisitions can be used to permit assessment of left ventricular function, and visualization of radiofrequency lesions created to treat arrhythmias. Workflows for each imaging goal have been developed and validated against gold standard clinical CT or histology. The challenges, opportunities, and limitations of the new functional C-arm CBCT imaging techniques will be discussed. Dr. W. Zbijewski (Johns Hopkins University) will present on the topic: Advances in CBCT for Orthopaedics and Bone Health Imaging. Cone-beam CT is particularly well suited for imaging of musculoskeletal extremities. Owing to the high spatial resolution of flat-panel detectors, CBCT can surpass conventional CT in imaging tasks involving bone visualization, quantitative analysis of subchondral trabecular structure, and visualization and monitoring of subtle fractures that are common in orthopedic radiology. A dedicated CBCT platform has been developed that offers flexibility in system design and provides not only a compact configuration with improved logistics for extremities imaging but also enables novel diagnostic capabilities such as imaging of weight-bearing lower extremities in a natural stance. The design, development and clinical performance of dedicated extremities CBCT systems will be presented. Advanced capabilities for quantitative volumetric assessment of joint space morphology, dual-energy image-based quantification of bone composition, and in-vivo analysis of bone microarchitecture will be discussed, along with emerging applications in the diagnosis of arthritis and osteoporosis and assessment of novel therapies. Finally, Dr. J. Boone (UC Davis) will present on the topic: Advances in CBCT for Breast Imaging. Breast CT has been studied as an imaging tool for diagnostic breast evaluation and for potential breast cancer screening. The breast CT application lends itself to CBCT because of the small dimensions of the breast, the tapered shape of the breast towards higher cone angle, and the fact that there are no bones in the breast. The performance of various generations of breast CT scanners developed in recent years will be discussed, focusing on advances in spatial resolution and image noise characteristics. The results will also demonstrate the results of clinical trials using both computer and human observers. Learning Objectives: Understand the challenges, key technological advances, and emerging opportunities of CBCT in: Brain perfusion imaging, including assessment of ischemic stroke Cardiac imaging for functional assessment in cardiac interventions Orthopedics imaging for evaluation of musculoskeletal trauma, arthritis, and osteoporosis Breast imaging for screening and diagnosis of breast cancer. Work presented in this symposium includes research support by: Siemens Healthcare (Dr. Chen); NIH and Siemens Healthcare (Dr. Fahrig); NIH and Carestream Health (Dr. Zbijewski); and NIH (Dr. Boone)

  1. TU-AB-204-00: Advances in Cone-Beam CT and Emerging Applications

    International Nuclear Information System (INIS)

    2015-01-01

    This symposium highlights advanced cone-beam CT (CBCT) technologies in four areas of emerging application in diagnostic imaging and image-guided interventions. Each area includes research that extends the spatial, temporal, and/or contrast resolution characteristics of CBCT beyond conventional limits through advances in scanner technology, acquisition protocols, and 3D image reconstruction techniques. Dr. G. Chen (University of Wisconsin) will present on the topic: Advances in C-arm CBCT for Brain Perfusion Imaging. Stroke is a leading cause of death and disability, and a fraction of people having an acute ischemic stroke are suitable candidates for endovascular therapy. Critical factors that affect both the likelihood of successful revascularization and good clinical outcome are: 1) the time between stroke onset and revascularization; and 2) the ability to distinguish patients who have a small volume of irreversibly injured brain (ischemic core) and a large volume of ischemic but salvageable brain (penumbra) from patients with a large ischemic core and little or no penumbra. Therefore, “time is brain” in the care of the stroke patients. C-arm CBCT systems widely available in angiography suites have the potential to generate non-contrast-enhanced CBCT images to exclude the presence of hemorrhage, time-resolved CBCT angiography to evaluate the site of occlusion and collaterals, and CBCT perfusion parametric images to assess the extent of the ischemic core and penumbra, thereby fulfilling the imaging requirements of a “one-stop-shop” in the angiography suite to reduce the time between onset and revascularization therapy. The challenges and opportunities to advance CBCT technology to fully enable the one-stop-shop C-arm CBCT platform for brain imaging will be discussed. Dr. R. Fahrig (Stanford University) will present on the topic: Advances in C-arm CBCT for Cardiac Interventions. With the goal of providing functional information during cardiac interventions, significant effort has been expended to improve the quantitative accuracy of C-arm CBCT reconstructions. The challenge is to improve image quality while providing very short turnaround between data acquisition and volume data visualization. Corrections for x-ray scatter, view aliasing and patient motion that require no more than 2 iterations keep processing time short while reducing artifact. Fast, multi-sweep acquisitions can be used to permit assessment of left ventricular function, and visualization of radiofrequency lesions created to treat arrhythmias. Workflows for each imaging goal have been developed and validated against gold standard clinical CT or histology. The challenges, opportunities, and limitations of the new functional C-arm CBCT imaging techniques will be discussed. Dr. W. Zbijewski (Johns Hopkins University) will present on the topic: Advances in CBCT for Orthopaedics and Bone Health Imaging. Cone-beam CT is particularly well suited for imaging of musculoskeletal extremities. Owing to the high spatial resolution of flat-panel detectors, CBCT can surpass conventional CT in imaging tasks involving bone visualization, quantitative analysis of subchondral trabecular structure, and visualization and monitoring of subtle fractures that are common in orthopedic radiology. A dedicated CBCT platform has been developed that offers flexibility in system design and provides not only a compact configuration with improved logistics for extremities imaging but also enables novel diagnostic capabilities such as imaging of weight-bearing lower extremities in a natural stance. The design, development and clinical performance of dedicated extremities CBCT systems will be presented. Advanced capabilities for quantitative volumetric assessment of joint space morphology, dual-energy image-based quantification of bone composition, and in-vivo analysis of bone microarchitecture will be discussed, along with emerging applications in the diagnosis of arthritis and osteoporosis and assessment of novel therapies. Finally, Dr. J. Boone (UC Davis) will present on the topic: Advances in CBCT for Breast Imaging. Breast CT has been studied as an imaging tool for diagnostic breast evaluation and for potential breast cancer screening. The breast CT application lends itself to CBCT because of the small dimensions of the breast, the tapered shape of the breast towards higher cone angle, and the fact that there are no bones in the breast. The performance of various generations of breast CT scanners developed in recent years will be discussed, focusing on advances in spatial resolution and image noise characteristics. The results will also demonstrate the results of clinical trials using both computer and human observers. Learning Objectives: Understand the challenges, key technological advances, and emerging opportunities of CBCT in: Brain perfusion imaging, including assessment of ischemic stroke Cardiac imaging for functional assessment in cardiac interventions Orthopedics imaging for evaluation of musculoskeletal trauma, arthritis, and osteoporosis Breast imaging for screening and diagnosis of breast cancer. Work presented in this symposium includes research support by: Siemens Healthcare (Dr. Chen); NIH and Siemens Healthcare (Dr. Fahrig); NIH and Carestream Health (Dr. Zbijewski); and NIH (Dr. Boone)

  2. TU-E-211-01: Establishing Multidisciplinary Collaboration as a Medical Physicist.

    Science.gov (United States)

    Xing, L; Fraass, B; Ford, E; Chang, S

    2012-06-01

    Many medical physicists are scientists at heart and their career fulfillment includes a balance of clinical service and research development. Multidisciplinary collaboration is a great way for the medical physicists to advance science and technology of our fields and the fields of our collaborators. Cross-pollination among scientists of different fields has been the key for some of the most significant breakthroughs in science and medicine and produced some of the most rewarding experiences for the individuals involved. However, medical physicists face unique challenges in establishing multidisciplinary collaboration because our time and resources for research are often quite limited compared to basic scientists. Yet we medical physicists are uniquely positioned and have a tremendous opportunity to create/contribute to multidisciplinary research: our fields are already multidisciplinary in nature and hospital environment is problem rich. How do we establish and carry out research collaboration with scientists of other fields? How to balance research with your higher priority clinical service? How do you find the right multidisciplinary collaboration in your own environment? We will discuss the challenges, provide real exemplary solutions to the above questions, and offer advise to medical physicists who are interested in starting or improving their multidisciplinary collaboration. There are different kinds of multidisciplinary collaborations a medical physicist can create and participate at different involvement levels. Multidisciplinary collaboration is not for every medical physicist but for those who seek and devote time to it, the experience can be truly rewarding and the impact can be enormous. 1. Learn the types of multidisciplinary collaboration medical physicists can created/participated 2. Learn the approaches and strategies to develop collaborations with scientists and professional of other fields3. Understand the challenges and different approaches to balance clinical service and multidisciplinary research collaboration. © 2012 American Association of Physicists in Medicine.

  3. Grand Challenges and Chemical Engineering Curriculum--Developments at TU Dortmund University

    Science.gov (United States)

    Kockmann, Norbert; Lutze, Philip; Gorak, Andrzej

    2016-01-01

    Chemical processing industry is progressively focusing their research activities and product placements in the areas of Grand Challenges (or Global Megatrends) such as mobility, energy, communication, or health care and food. Innovation in all these fields requires solving high complex problems, rapid product development as well as dealing with…

  4. TU-C-BRE-10: A Streamlined Approach to EPID Transit Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Morris, B; Fontenot, J [Louisiana State University, Baton Rouge, LA (United States); Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States)

    2014-06-15

    Purpose: To investigate the feasibility of a simple and efficient transit dosimetry method using the electronic portal imaging device (EPID) for dose delivery error detection and prevention. Methods: In the proposed method, 2D reference transit images are generated for comparison with online images acquired during treatment. Reference transit images are generated by convolving through-air EPID measurements of each field with pixel-specific kernels selected from a library of pre-calculated Monte Carlo pencil kernels of varying radiological thickness. The kernel used for each pixel is selected based on the calculated radiological thickness of the patient along a line joining the pixel and the virtual source. The accuracy of the technique was evaluated in flat homogeneous and heterogeneous plastic water phantoms, a heterogeneous cylindrical phantom, and an anthropomorphic head phantom. Gamma criteria of 3%/3 mm was used to quantify the accuracy of the technique for the various cases. Results: An average of 99.9% and 99.7% of the points in the comparison between the measured and predicted images passed a 3%/3mm gamma for the homogeneous and heterogeneous plastic water phantoms, respectively. 97.1% of the points passed for the analysis of the heterogeneous cylindrical phantom. For the anthropomorphic head phantom, an average of 97.8% of points passed the 3%/3mm gamma criteria for all field sizes. Failures were observed primarily in areas of drastic thickness or material changes and at the edges of the fields. Conclusion: The data suggest that the proposed transit dosimetry method is a feasible approach to in vivo dose monitoring. Future research efforts could include implementation for more complex fields and sensitivity testing of the method to setup errors and changes in anatomy. Oncology Data Systems provided partial funding support but did not participate in the collection or analysis of data.

  5. Marca la diferencia en tu comunidad (Make a Difference in Your Community)

    Centers for Disease Control (CDC) Podcasts

    2013-04-23

    En este podcast los niños de Kidtastics hablan sobre lo que ellos pueden hacer para que las escuelas y las comunidades sean sitios más saludables.  Created: 4/23/2013 by Centers for Disease Control and Prevention (CDC).   Date Released: 12/11/2013.

  6. Innovative collection development for e-books at the TU Delft Library

    NARCIS (Netherlands)

    Brinkman Dzwig, Z.E.

    2013-01-01

    Thanks to new technologies libraries worldwide go digital and are accessible 24/7 from remote locations. The innovation is even more visible in traditional library tasks such as collection development and acquisitions. Those tasks are undergoing rapid transformation as well. One of the reasons is

  7. TU-F-CAMPUS-T-04: Using Gold Nanoparticles to Target Mitochondria in Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    McNamara, A [Massachusetts General Hospital & Harvard Med. Sch., Boston, MA (United States); McMahon, S [Massachusetts General Hospital, Boston, Ma (United States); Lin, Y [Massachusetts General Hospital and Harvard Medical School, Boston, MA (United States); Paganetti, H; Schuemann, J [Massachusetts General Hospital, Boston, MA (United States); Kuncic, Z [University of Sydney, Sydney, NSW (Australia)

    2015-06-15

    Purpose: The mitochondrion, like the cell nucleus, contains genetic material and plays several critical roles that determine the cell viability, including neutralization of free radicals within the cell. Studies have shown that irradiated cells with impaired mitochondria will incur more damage to the cell nucleus. This study investigates the potential use of GNPs to enhance radiation-induced damage to the organelle. Methods: The compositions of the organelles of a JURKAT cell were determined experimentally. Using Monte Carlo simulations, we investigate the significance of dose enhancement in a monoenergetic (10–50 keV and 6 MeV) x-ray irradiated cell cytoplasm, consisting of the experimentally determined composition. We also investigate the track structure of secondary electrons in the mitochondria using Geant4-DNA in the presence and absence of GNPs for incident protons and photons. The biological effect was determined using an approach based on the local effect model, assuming the mitochondrial DNA (mtDNA) was the primary target. Results: Adding 0.01% of gold to the cell cytoplasm material can cause substantial dose enhancement, dependent on the incident x-ray energy. Track structure Monte Carlo (MC) simulations show an increased number of ionization events within the mitochondrion structure. The close proximity of GNPs to the mtDNA storing nucleoid may cause the mtDNA to receive doses above ∼100 Gy for keV x-rays, leading to mitochondrial dysfunction. Conclusion: A substantial increase in ionization events can occur in the mitochondria in the presence of GNPs. If GNPs can be delivered to tumors and attached to a sufficient number of mitochondria inside the tumor cells, mitochondrial induced cell death could be a prevalent cause of cell death. The biological structures developed here will be included in the biological MC toolkit, TOPAS-nBio.

  8. « Comment le sais-tu ? ». La paralepse, aujourd’hui

    Directory of Open Access Journals (Sweden)

    Frank Wagner

    2013-04-01

    Full Text Available À partir des définitions genettiennes de la paralepse (excès d’informations par rapport au code modal dominant, il s’agit de cerner les usages et les fonctions du procédé dans la littérature narrative d’aujourd’hui, en relation homo- ou hétérodiégétique, en régime fictionnel ou semi-fictionnel. Des exemples prélevés dans divers récits contemporains (de Roegiers, Toussaint, Carrère, Echenoz permettent de constater que la paralepse assure un renouvellement du soupçon à l’époque actuelle, en jouant un rôle de révélateur épistémologique. En effet, ce procédé narratif paradoxal engage une réflexion en acte sur la fiction, son perspectivisme, ses capacités de modélisation, et ses pouvoirs heuristiques.Based upon Gerard Genette’s definitions of paralepsis, (information exceeding that normally offered by the dominant mode of narrative focalisation, this article seeks to outline the uses and functions of the device in contemporary narrative literature, through its homo and heterodiegetic positioning in both fictional and semi-fictional texts. Examples taken from a variety of contemporary stories (Roegiers, Toussaint, Carrère, Echenoz allow us to see that paralepsis plays a role of epistemological indicator, facilitating a contemporary renewal of suspicion (le soupçon concerning narration. In fact, this paradoxical narrative device brings about a reflection upon fiction, its perspectivism, its modelling capabilities and heuristic capacities.

  9. Anne, ma soeur Anne, ne vois-tu rien venir? Que oui! | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    23 déc. 2010 ... Les montagnes peuvent nous donner des signes précurseurs du sort réservé à la planète tout entière. L'Organisation des Nations Unies a désigné 2002 Année internationale de la montagne. Ce choix peut paraître bien inusité. Après tout, 60 pour cent de la population mondiale ne vit-elle pas dans un ...

  10. Preparation, production and labelling of scFv against TU-20 and HIV

    Czech Academy of Sciences Publication Activity Database

    Fábry, Milan; Sedláček, Juraj; Kronrád, L.; Málek, Z.; Viklický, Vladimír

    2003-01-01

    Roč. 18, č. 2 (2003), s. 285 ISSN 1084-9785 R&D Projects: GA MŠk OE67/1 Institutional research plan: CEZ:AV0Z5052915 Keywords : neurotubulin * antibody * labelling Subject RIV: CE - Biochemistry Impact factor: 1.841, year: 2003

  11. TU-AB-BRA-01: Abdominal Synthetic CT Generation in Support of Liver SBRT Dose Calculation

    Energy Technology Data Exchange (ETDEWEB)

    Bredfeldt, JS; Liu, L; Feng, M [University of Michigan, Ann Arbor, MI (United States); Cao, Y [The University of Michigan, Ann Arbor, MI (United States); Balter, J [University Michigan, Ann Arbor, MI (United States)

    2016-06-15

    Purpose: To demonstrate and validate a technique for generating MRI-derived synthetic CT volumes (MRCTs) in support of adaptive liver SBRT. Methods: Under IRB approval, ten hepatocellular carcinoma patients were scanned using a single MR sequence (T1 Dixon-VIBE), yielding inherently-registered water, fat, and T1-weighted images. Air-containing voxels were identified by intensity thresholding. The envelope of the anterior vertebral bodies was segmented from the fat image by fitting a shape model to vertebral body candidate voxels, then using level sets to expand the contour outward. Fuzzy-C-Means (FCM) was then used to classify each non-air voxel in the image as fat, water, bone, or marrow. Bone and marrow only were classified within the vertebral body envelope. The MRCT was created by integrating the product of the FCM class probability with the assigned class density for each voxel. The resulting MRCTs were deformably aligned with planning CTs and 2-ARC SBRT VMAT plans were optimized on the MRCT density maps. Fluence was copied onto the CT density grids and dose recalculated. Results: The MRCTs faithfully reproduced most of the features visible in the corresponding CT image volumes, with exceptions of ribs and posterior spinous processes. The liver, vertebral bodies, kidneys, spleen and cord all had median HU differences of less than 75 between MRCT and CT images. PTV D99% values had an average 0.2% difference (standard deviation: 0.46%) between calculations on MRCT and CT density grids. The maximum difference in dose to 0.1cc of the PTV was 0.25% (std:0.49%). OAR dose differences were similarly small (mean:0.03Gy, std:0.26Gy). The largest normal tissue complication percentage (NTCP) difference was 1.48% (mean:0.06%, std:0.54%). Conclusions: MRCTs from a single abdominal imaging sequence are promising for use in SBRT dose calculation. Future work will focus on extending models to better define bones in the upper abdomen. Supported by NIHR01EB016079 and NIH1L30CA199594-01.

  12. Vztah mýtu a literatury na tématu vlkodlaka

    OpenAIRE

    Benešová, Anna

    2013-01-01

    anglicky: Title of the thesis: Myth and Literature: The Werewolf Keywords: myth, literature, mythology, mythodology, mythanalysis, mythocriticism, werewolf Abstract: This thesis deals with the relation between literature and myth. Literature transcribes the myth from a language of symbols to the language of literature. This process limits the multiplicity of meaning and the variety of renderings of a myth but at the same time makes it possible to preserve the elemental message and make it com...

  13. TU-E-201-02: Eye Lens Dosimetry From CT Perfusion Studies

    International Nuclear Information System (INIS)

    Zhang, D.

    2015-01-01

    Madan M. Rehani, Massachusetts General Hospital and Harvard Medical School, Boston Methods for Eye Lens Dosimetry and Studies On Lens Opacities with Interventionalists Radiation induced cataract is a major threat among staff working in interventional suites. Nearly 16 million interventional procedures are performed annually in USA. Recent studies by the principal investigator’s group, primarily among interventional cardiologists, on behalf of the International Atomic Energy Agency, show posterior subcapsular (PSC) changes in the eye lens in 38–53% of main operators and 21–45% of support staff. These changes have potential to lead to cataract in future years, as per information from A-Bomb survivors. The International Commission on Radiological Protection has reduced dose limit for staff by a factor of 7.5 (from 150 mSv/y to 20 mSv/y). With increasing emphasis on radiation induced cataracts and reduction in threshold dose for eye lens, there is a need to implement strategies for estimating eye lens dose. Unfortunately eye lens dosimetry is at infancy when it comes to routine application. Various approaches are being tried namely direct measurement using active or passive dosimeters kept close to eyes, retrospective estimations and lastly correlating patient dose in interventional procedures with staff eye dose. The talk will review all approaches available and ongoing active research in this area, as well as data from surveys done in Europe on status of eye dose monitoring in interventional radiology and nuclear medicine. The talk will provide update on how good is Hp(10) against Hp(3), estimations from CTDI values, Monte Carlo based simulations and current status of eye lens dosimetry in USA and Europe. The cataract risk among patients is in CT examinations of the head. Since radiation induced cataract predominantly occurs in posterior sub-capsular (PSC) region and is thus distinguishable from age or drug related cataracts and is also preventable, actions on awareness can lead to avoidance or even prevention. Learning Objectives: To understand recent changes in eye lens dose limits and thresholds for tissue reactions To understand different approaches to dose estimation for eye lens To learn about challenges in eye lens opacities among staff in interventional fluoroscopy Di Zhang, Toshiba America Medical Systems, Tustin, CA, USA Eye lens radiation dose from brain perfusion CT exams CT perfusion imaging requires repeatedly exposing one location of the head to monitor the uptake and washout of iodinated contrast. The accumulated radiation dose to the eye lens can be high, leading to concerns about potential radiation injury from these scans. CTDIvol assumes continuous z coverage and can overestimate eye lens dose in CT perfusion scans where the table do not increment. The radiation dose to the eye lens from clinical CT brain perfusion studies can be estimated using Monte Carlo simulation methods on voxelized patient models. MDCT scanners from four major manufacturers were simulated and the eye lens doses were estimated using the AAPM posted clinical protocols. They were also compared to CTDIvol values to evaluate the overestimation from CTDIvol. The efficacy of eye lens dose reduction techniques such as tilting the gantry and moving the scan location away from the eyelens were also investigated. Eye lens dose ranged from 81 mGy to 279 mGy, depending on the scanner and protocol used. It is between 59% and 63% of the CTDIvol values reported by the scanners. The eye lens dose is significantly reduced when the eye lenses were not directly irradiated. CTDIvol should not be interpreted as patient dose; this study has shown it to overestimate dose to the eye lens. These results may be used to provide more accurate estimates of actual dose to ensure that protocols are operated safely below thresholds. Tilting the gantry or moving the scanning region further away from the eyes are effective for reducing lens dose in clinical practice. These actions should be considered when they are consistent with the clinical task and patient anatomy. Learning Objectives: To become familiar with method of eye dose estimation for patient in specific situation of brain perfusion CT To become familiar with level of eye lens radiation doses in patients undergoing brain perfusion MDCT To understand methods for reducing eye lens dose to patient Jong Min Park, Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea Eye lens dosimetry in radiotherapy using contact lens-shaped applicator Dose calculation accuracy of commercial treatment planning systems is relatively low at shallow depths. Therefore, in-vivo measurements are often performed in the clinic to verify delivered doses to eye lens which are located at shallow depth. Current in-vivo dosimetry for eye lens during radiotherapy is generally performed with small in-vivo dosimeters on the surface of patient eyelid. Since this procedure potentially contains considerable uncertainty, a contact lens-shaped applicator made of acrylic (lens applicator) was developed for in-vivo measurements of eye lens dose during radiotherapy to reduce uncertainty. The lens applicator allows the insertion of commercially available metal oxide semiconductor field effect transistor (MOSFET) dosimeters. Computed tomography (CT) images of an anthropomorphic phantom with and without the lens applicator were acquired. A total of 20 VMAT plans were delivered to an anthropomorphic phantom and the doses with the lens applicator and the doses at the surface of the eyelid were measured using both micro and standard MOSFET dosimeters. The differences in measured dose at the surface of the eyelid from the calculated lens dose were acquired. The differences between the measured and the calculated doses at the lens applicator, as well as the differences between the measured and the calculated doses at the surface of the eyelid were acquired. The statistical significance of the differences was analyzed. The average difference between the measured and the calculated dose with the lens applicator was 16.8 % ± 10.4 % with a micro MOSFET dosimeter and 16.6 % ± 10.9% with a standard MOSFET dosimeter. The average difference without the lens applicator was 35.9% ± 41.5% with micro MOSFET dosimeter and 42.9% ± 52.2% with standard MOSFET dosimeter. The maximum difference with micro MOSFET dosimeter was 46% with the applicator and 188.4% without the applicator. For the standard MOSFET dosimeter, the maximum difference was 44.4% with the applicator and 246.4% without the applicator. The lens applicator allowed reduction of the differences between the calculated and the measured dose during in-vivo measurement for the eye lens as compared to in-vivo measurement at the surface of the eyelid. Learning Objectives: To understand limitations of dose calculation with commercial treatment planning system for eye lens during radiotherapy To learn about current in-vivo dosimetry methods for eye lens in the clinic To understand limitations of in-vivo dosimetry for eye lens during radiotherapy Di Zhang is an employee of Toshiba America Medical Systems

  14. Et tu, Brute? Not Even Intracellular Mutualistic Symbionts Escape Horizontal Gene Transfer

    Directory of Open Access Journals (Sweden)

    Sergio López-Madrigal

    2017-09-01

    Full Text Available Many insect species maintain mutualistic relationships with endosymbiotic bacteria. In contrast to their free-living relatives, horizontal gene transfer (HGT has traditionally been considered rare in long-term endosymbionts. Nevertheless, meta-omics exploration of certain symbiotic models has unveiled an increasing number of bacteria-bacteria and bacteria-host genetic transfers. The abundance and function of transferred loci suggest that HGT might play a major role in the evolution of the corresponding consortia, enhancing their adaptive value or buffering detrimental effects derived from the reductive evolution of endosymbionts’ genomes. Here, we comprehensively review the HGT cases recorded to date in insect-bacteria mutualistic consortia, and discuss their impact on the evolutionary success of these associations.

  15. TU-D-201-07: Severity Indication in High Dose Rate Brachytherapy Emergency Response Procedure

    Energy Technology Data Exchange (ETDEWEB)

    Li, K [Associates in Medical Physics, Hagerstown, MD (United States); Rustad, F [Associates In Medical Physics, Lanham, MD (United States)

    2016-06-15

    Purpose: Understanding the corresponding dose to different staff during the High Dose Rate (HDR) Brachytherapy emergency response procedure could help to develop a strategy in efficiency and effective action. In this study, the variation and risk analysis methodology was developed to simulation the HDR emergency response procedure based on severity indicator. Methods: A GammaMedplus iX HDR unit from Varian Medical System was used for this simulation. The emergency response procedure was decomposed based on risk management methods. Severity indexes were used to identify the impact of a risk occurrence on the step including dose to patient and dose to operation staff by varying the time, HDR source activity, distance from the source to patient and staff and the actions. These actions in 7 steps were to press the interrupt button, press emergency shutoff switch, press emergency button on the afterloader keypad, turn emergency hand-crank, remove applicator from the patient, disconnect transfer tube and move afterloader from the patient, and execute emergency surgical recovery. Results: Given the accumulated time in second at the assumed 7 steps were 15, 5, 30, 15, 180, 120, 1800, and the dose rate of HDR source is 10 Ci, the accumulated dose in cGy to patient at 1cm distance were 188, 250, 625, 813, 3063, 4563 and 27063, and the accumulated exposure in rem to operator at outside the vault, 1m and 10cm distance were 0.0, 0.0, 0.1, 0.1, 22.6, 37.6 and 262.6. The variation was determined by the operators in action at different time and distance from the HDR source. Conclusion: The time and dose were estimated for a HDR unit emergency response procedure. It provided information in making optimal decision during the emergency procedure. Further investigation would be to optimize and standardize the responses for other emergency procedure by time-spatial-dose severity function.

  16. TU-AB-201-07: Image Guided Endorectal HDR Brachytherapy Using a Compliant Balloon Applicator

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, G; Goodman, K [Memorial Sloan Kettering Cancer Center, New York, NY (United States)

    2015-06-15

    Purpose: High dose rate endorectal brachytherapy is an option to deliver a focal, high-dose radiotherapy to rectal tumors for patients undergoing non-operative management. We investigate a new multichannel, MR compatible applicator with a novel balloon-based design to provide improved treatment geometry. We report on the initial clinical experience using this applicator. Methods: Patients were enrolled on an IRB-approved, dose-escalation protocol evaluating the use of the anorectal (AR-1) applicator (Ancer Medical, Hialeah, FL), a multichannel applicator with two concentric balloons. The inner balloon supports 8 source lumens; the compliant outer balloon expands to separate the normal rectal wall and the source lumens, yet deforms around a firm, exophytic rectal mass, leading to dose escalation to tumor while sparing normal rectum. Under general anesthesia, gold fiducial markers were inserted above and below the tumor, and the AR applicator was placed in the rectum. MRI-based treatment plans were prepared to deliver 15 Gy in 3 weekly fractions to the target volume while sparing healthy rectal tissue, bladder, bowel and anal muscles. Prior to each treatment, CBCT/Fluoroscopy were used to place the applicator in the treatment position and confirm the treatment geometry using rigid registration of the CBCT and planning MRI. After registration of the applicator images, positioning was evaluated based on the match of the gold markers. Results: Highly conformal treatment plans were achieved. MR compatibility of the applicator enabled good tumor visualization. In spite of the non-rigid nature of the applicators and the fact that a new applicator was used at each treatment session, treatment geometry was reproducible to within 2.5 mm. Conclusions: This is the first report on using the AR applicator in patients. Highly conformal plans, confidence in MRI target delineation, in combination with reproducible treatment geometry provide encouraging feedback for continuation with dose escalation in these patients.

  17. TU-EF-204-04: Feasibility Study of a Novel Stationary Spectral CT Scanner

    International Nuclear Information System (INIS)

    Xu, P; Xing, X; Zheng, J; Chen, S; Zhang, Y; Yuan, G; Sun, M

    2015-01-01

    Purpose: To evaluate a cadmium zinc telluride (CZT) detector module and to develop a proof-of-concept bench-top system to examine the concept and feasibility of a stationary spectral scanner that would consist of a CZT detector ring and a distributed source for rotationless imaging. Methods: The bench-top system employs a double-rotation set-up with two concentric but independent rotating stages, one for turning the object at sparse angles to mimic the imaging from a sequentially activated source distributed on a ring, while the other for translating the detector module to simulate a projection arc along a virtual detector ring. A source of 30-degree fan is used in the set-up, and the ring is designed to be 85cm in diameter in order to provide a 22cm field-of-view that is large enough for an average human head. The CZT detector module has 16×16 0.5mm pixels and eight global energy thresholds, and is attached to an experimental data acquisition board from the same vendor (Nova R&D). Its pixel gain is first calibrated using radioisotope Tc-99m to align the photo-peaks. Count rate performance is assessed using the X-ray source. Air and offset corrections are done prior to each CT scan. A 10cm acrylic phantom with 5 different inserts is imaged at 100kVp, 2mA, with an effective exposure window of 150ms per projection. Reconstruction is done using a total variation-type iterative method. Results: The detector module exhibited large gain variations among pixels. Average count rate was over 1Mcps per pixel. Parallax effect was observed along the arcs but was corrected. Reconstructed images from two energy bins demonstrated good contrast, spatial resolution and image uniformity, with little artifacts. Conclusion: The CZT detector tested is suitable for imaging relatively small objects. A stationary spectral CT appears feasible should we have enough buttable modules and a distributed source. This work was supported by Ministry of Science and Technology of China through grants 11YQ040082 and 2012BAI13B04

  18. TU-F-9A-01: Balancing Image Quality and Dose in Radiography

    International Nuclear Information System (INIS)

    Peck, D; Pasciak, A

    2014-01-01

    Emphasis is often placed on minimizing radiation dose in diagnostic imaging without a complete consideration of the effect on image quality, especially those that affect diagnostic accuracy. This session will include a patient image-based review of diagnostic quantities important to radiologists in conventional radiography, including the effects of body habitus, age, positioning, and the clinical indication of the exam. The relationships between image quality, radiation dose, and radiation risk will be discussed, specifically addressing how these factors are affected by image protocols and acquisition parameters and techniques. This session will also discuss some of the actual and perceived radiation risk associated with diagnostic imaging. Regardless if the probability for radiation-induced cancer is small, the fear associated with radiation persists. Also when a risk has a benefit to an individual or to society, the risk may be justified with respect to the benefit. But how do you convey the risks and the benefits to people? This requires knowledge of how people perceive risk and how to communicate the risk and the benefit to different populations. In this presentation the sources of errors in estimating risk from radiation and some methods used to convey risks are reviewed. Learning Objectives: Understand the image quality metrics that are clinically relevant to radiologists. Understand how acquisition parameters and techniques affect image quality and radiation dose in conventional radiology. Understand the uncertainties in estimates of radiation risk from imaging exams. Learn some methods for effectively communicating radiation risk to the public

  19. TU-F-CAMPUS-T-04: Using Gold Nanoparticles to Target Mitochondria in Radiation Therapy

    International Nuclear Information System (INIS)

    McNamara, A; McMahon, S; Lin, Y; Paganetti, H; Schuemann, J; Kuncic, Z

    2015-01-01

    Purpose: The mitochondrion, like the cell nucleus, contains genetic material and plays several critical roles that determine the cell viability, including neutralization of free radicals within the cell. Studies have shown that irradiated cells with impaired mitochondria will incur more damage to the cell nucleus. This study investigates the potential use of GNPs to enhance radiation-induced damage to the organelle. Methods: The compositions of the organelles of a JURKAT cell were determined experimentally. Using Monte Carlo simulations, we investigate the significance of dose enhancement in a monoenergetic (10–50 keV and 6 MeV) x-ray irradiated cell cytoplasm, consisting of the experimentally determined composition. We also investigate the track structure of secondary electrons in the mitochondria using Geant4-DNA in the presence and absence of GNPs for incident protons and photons. The biological effect was determined using an approach based on the local effect model, assuming the mitochondrial DNA (mtDNA) was the primary target. Results: Adding 0.01% of gold to the cell cytoplasm material can cause substantial dose enhancement, dependent on the incident x-ray energy. Track structure Monte Carlo (MC) simulations show an increased number of ionization events within the mitochondrion structure. The close proximity of GNPs to the mtDNA storing nucleoid may cause the mtDNA to receive doses above ∼100 Gy for keV x-rays, leading to mitochondrial dysfunction. Conclusion: A substantial increase in ionization events can occur in the mitochondria in the presence of GNPs. If GNPs can be delivered to tumors and attached to a sufficient number of mitochondria inside the tumor cells, mitochondrial induced cell death could be a prevalent cause of cell death. The biological structures developed here will be included in the biological MC toolkit, TOPAS-nBio

  20. Yo pongo, tu pones, todos ponen para ayudar a las familias de nuestra comunidad

    Directory of Open Access Journals (Sweden)

    Alexandra García-Rueda

    2013-12-01

    Full Text Available Objetivo: gestionar la creación y puesta en marcha de una red de apoyo intersectorial, cuyo fin es brindar soporte y contribuir a la solución de la problemática de las familias. Materiales y Métodos: estudio descriptivo, llevado a cabo en 42 familias, 15 líderes comunitarios y representantes de 8 instituciones y 11 trabajadores del centro de salud de un barrio de estratos 1 y 2 de la ciudad de Bucaramanga. Se aplicó un formato de valoración por dominios de la Asociación Norteamericana de Diagnósticos de Enfermería (NANDA para identificar la problemática de las familias. El procesamiento de los datos, se realizó en Excel mediante la obtención de frecuencias y promedios para su posterior análisis. Resultados: se logró la creación y puesta en marcha de la red de apoyo, conformada por ocho instituciones del sector, con la cual se abordaron problemáticas como: inasistencia a programas de promoción y prevención, drogadicción, violencia intrafamiliar, embarazos en adolescentes. Conclusiones: la articulación interinstitucional y la conformación de redes de apoyo logran mejores efectos a nivel económico, social, espiritual, físico y psicológico, contribuyendo a la salud familiar. Asimismo, contribuye al desarrollo personal, profesional, liderazgo y construcción del conocimiento, propios de enfermería familiar como eje de abordaje en la salud pública

  1. TU-D-209-01: Dosimetry of Diagnostic Work Up Mammography

    Energy Technology Data Exchange (ETDEWEB)

    Jallow, N [Emory University, Atlanta, GA (United States); Sechopoulos, I [Radboud University Medical Centre, Nijmegen (Netherlands)

    2016-06-15

    Purpose: To investigate patient average glandular dose (AGD) characteristics of diagnostic mammography. Methods: The techniques used to image 14420 patients who received diagnostic work up mammography from October 2008 to December 2014 at one academic hospital were retrospectively collected. The most common diagnostic views and the techniques used for each according to compressed breast thickness were determined. For all techniques, 1st half value layer and air kerma output per tube current-exposure time product were measured; then the incident air kerma for each acquisition was calculated. The values for normalized glandular dose (DgN) were obtained with a validated Monte Carlo simulation of mammographic acquisition. The mono-energetic DgN results were combined according to relative fluence using the TASMICS model to obtain DgN coefficients for each spectrum. The spectral DgN and calculated incident air kerma were used to estimate AGD of patients with breast thickness ranging from 2 to 8 cm. Results: The most common views utilized during diagnostic mammography were magnification craniocaudal (24%), magnification mediolateral (19%), spot craniocaudal (28%), and spot mediolateral oblique (24%). The AGD increased with increasing breast thickness for both the magnification and spot views. The AGD for a 5.5 cm thick breast was approximately 6.8 mGy and 2.2 mGy for the magnification and spot views, respectively. The AGD ranged from 3.6 mGy to 6.8 mGy for the magnification views and from 1.0 mGy to 3.1 mGy for spot views. The difference in AGD between the two magnification views or the two spot views was not significant. Conclusion: These results provide information on breast dose to which screening recalled women are exposed to. In addition to understanding the dose used for common clinical imaging tests, this data could be used when comparing use of mammography for diagnostic workup to other potential modalities, such as breast tomosynthesis and breast CT.

  2. TU-A-17A-01: Memorial to Benjamin M. Galkin - Memorial Lecture

    Energy Technology Data Exchange (ETDEWEB)

    Suntharalingam, N [Voorhees, NJ (United States)

    2014-06-15

    This past year Medical Physics lost one of its active members, Benjamin M. Galkin. Ben Galkin was a Past-Treasurer of the AAPM. During his leadership role he played an important part in Securing membership, for the AAPM, in the American Institute of physics. As Treasurer he was also a prime mover in starting the journal, Medical Physics, and served as its business manager in the formative years.Ben Galkin received his Masters Degree at Columbia University in New York, under the mentorship of Dr. Edith Quimby, one of the pioneer Hospital Radiation Physicists in the country. He started his professional career at Jefferson Hospital in Philadelphia, joining Robert Gorson, and remained there until retirement. He served as the institution’s Radiation Safety Officer throughout his career. His research interest was Breast Imaging. He held joint faculty appointments in the Department of Radiology and the Department of Radiation Therapy and Nuclear Medicine, rising up to the rank of Full professor. He was a well respected teacher for the residents in Radiology.

  3. TU-CD-303-00: In Memoriam of Warren Sinclair: Physics Applications for New Radiobiology

    International Nuclear Information System (INIS)

    2015-01-01

    The Medical Physics and Radiation Protection communities lost one of their true pioneers in May, 2014 with the passing of Warren K. Sinclair, Ph.D. He received his Doctorate in Physics at the University of London, U.K. He was a fellow of the Institute of Physics and a Certified Health Physicist. After a number of posts at Hospitals and Universities in the U.K. and New Zealand, he became the Head, Physics Department at the M.D. Anderson Hospital, Houston, TX. He held a number of academic physics positions with the University of Texas, Austin at the main campus and at the Postgraduate School of Medicine, Houston. He later served as a Senior Biophysicist, Division Director, and then Associate Laboratory Director for Biomedical Division Director, and then Associate Laboratory Director for Biomedical and Environmental Research at the Argonne National Laboratory, IL. He had additional academic appointments at the University of California, Berkeley; Northern Illinois University; the University of Illinois (Chicago Circle Campus); and the University of Chicago. Warren was a charter member of the AAPM and a leader in many communities: President of the AAPM from 1960 to 1961 and the Journal Editor from 1964 to 1969, the 2nd President of the NCRP from 1977 to 1991, and the President of the Radiation Research Society from 1978 to 1979. His many awards included the William D. Coolidge Award in 1986. Even this barely scratches the surface of the many other organizations he served with and influenced including the ICRP, IOP, RSNA, SNM, and UNSCEAR. His research interests resulted in publications from 1948 to the 1990s in many aspects (physical and biological) of radiotherapy and the effects of ionizing radiation in general, leading to early definitions of RBE values for megavoltage radiotherapy as well as contributing to the development of the modern framework for radiation protection worldwide. Warren was not a retiring person and even after moving to NCRP President Emeritus status continued to provide advice and comments on publications and to mentor others until the time of his passing. Sadly, Warren’s long-time wife Joy passed away in December, 2014 but he is survived by his son Bruce and daughter Roslyn, 2 grandchildren and 4 great-grandchildren

  4. TU-FG-201-10: Quality Management of Accelerated Partial Breast Irradiation (APBI) Plans

    International Nuclear Information System (INIS)

    Ji, H; Lorio, V; Cernica, G; Han, J; Nurhussien, M; Nasr, N; Hong, R

    2016-01-01

    Purpose: Since 2008, over 700 patients received high dose rate (HDR) APBI treatment at Virginia Hospital Center. The complexity involved in the planning process demonstrated a broad variation between patient geometry across all applicators, in relation to anatomical regions of interest. A quality management program instituting various metrics was implemented in March 2013 with the goal of ensuring an optimal plan is achieved for each patient. Methods: For each plan, an in-house complexity index, geometric conformity index, and plan quality index were defined. These indices were obtained for all patients treated. For patients treated after the implementation, the conformity index and quality index were maximized while other dosimetric limits, such as maximum skin and rib doses, were strictly kept. Subsequently, all evaluation parameters and applicator information were placed in a database for cross-evaluation with similar complexity. Results: Both the conformity and quality indices show good correlation with the complexity index. They decrease as complexity increases for all applicators. Multi lumen type balloon applicators demonstrate a minimal advantage over single lumen applicators in increasingly complex patient geometries, as compared to SAVI applicators which showed considerably greater advantage in these circumstances. After the implementation of the in-house planning protocol, there is a direct improvement of quality for SAVI plans. Conclusion: Due to their interstitial nature, SAVI devices show a better conformity in comparison to balloon-based devices regardless of the number of lumens, especially in complex cases. The quality management program focuses on optimizing indices by utilizing prior planning knowledge based on complexity levels. The database of indices assists in decision making and has subsequently aided in balancing the experience level among planners. This approach has made APBI planning more robust for patient care, with a measurable improvement in the plan quality.

  5. TU-C-BRF-01: Innovation in Medical Physics and Engineering

    International Nuclear Information System (INIS)

    Mohan, R; Pelc, N; Jaffray, D; Mackie, T

    2014-01-01

    We seek to heighten the awareness of the role of research and innovation that leads to clinical advances in the field of medical physics and engineering. Marie Curie (discovery and use of radium) and Harold Johns (Co-60 tele-therapy) in radiotherapy, and pioneers in imaging (Allan Cormack and Godfrey Hounsfield for the CT and Paul Lauterbur, Peter Mansfield for MRI, etc.) were scientists often struggling against great odds. Examples of more recent innovations that are clearly benefitting our patients include IMRT, Image Guided Radiation Therapy and Surgery, Particle Therapy, Quantitative imaging, amongst others.We would also like to highlight the fact that not all of the discovery and engineering that we benefit from in today’s world, was performed at research institutions alone. Rather, companies often tread new ground at financial and reputational risk. Indeed the strength of the private sector is needed in order to bring about new advances to our practice. The keys to long term success in research and development may very well include more public and private research spending. But, when more investigators are funded, we also need to recognize that there needs to be a willingness on the part of the funding institutions, academic centers and investigators to risk failure for the greater potential achievements in innovation and research. The speakers will provide examples and insight into the fields of innovation and research in medical physics from their own first hand experiences. Learning Objectives: To obtain an understanding of the importance of research and development towards advances in physics in medicine. To raise awareness of the role of interdisciplinary collaborations in translational research and innovation. To highlight the importance of entrepreneurships and industrial-institutional research partnerships in fostering new ideas and their commercial success. To recognize and account for the risk of failure for the greater potential achievements in innovation and research

  6. TU-FG-201-04: Computer Vision in Autonomous Quality Assurance of Linear Accelerators

    International Nuclear Information System (INIS)

    Yu, H; Jenkins, C; Yu, S; Yang, Y; Xing, L

    2016-01-01

    Purpose: Routine quality assurance (QA) of linear accelerators represents a critical and costly element of a radiation oncology center. Recently, a system was developed to autonomously perform routine quality assurance on linear accelerators. The purpose of this work is to extend this system and contribute computer vision techniques for obtaining quantitative measurements for a monthly multi-leaf collimator (MLC) QA test specified by TG-142, namely leaf position accuracy, and demonstrate extensibility for additional routines. Methods: Grayscale images of a picket fence delivery on a radioluminescent phosphor coated phantom are captured using a CMOS camera. Collected images are processed to correct for camera distortions, rotation and alignment, reduce noise, and enhance contrast. The location of each MLC leaf is determined through logistic fitting and a priori modeling based on knowledge of the delivered beams. Using the data collected and the criteria from TG-142, a decision is made on whether or not the leaf position accuracy of the MLC passes or fails. Results: The locations of all MLC leaf edges are found for three different picket fence images in a picket fence routine to 0.1mm/1pixel precision. The program to correct for image alignment and determination of leaf positions requires a runtime of 21– 25 seconds for a single picket, and 44 – 46 seconds for a group of three pickets on a standard workstation CPU, 2.2 GHz Intel Core i7. Conclusion: MLC leaf edges were successfully found using techniques in computer vision. With the addition of computer vision techniques to the previously described autonomous QA system, the system is able to quickly perform complete QA routines with minimal human contribution.

  7. Fyziologie glutamátu, dlouhodobá potenciace, schizofrenie a paměť

    Czech Academy of Sciences Publication Activity Database

    Stuchlík, Aleš; Svojanovská, Markéta

    2014-01-01

    Roč. 63, č. 2 (2014), s. 84-91 ISSN 1210-6313 R&D Projects: GA ČR(CZ) GA14-03627S; GA MZd(CZ) NT13386; GA MŠk(CZ) LH14053 Grant - others:Rada Programu interní podpory projektů mezinárodní spolupráce AV ČR(CZ) M200111204 Institutional support: RVO:67985823 Keywords : glutamate * memory * NMDA receptors Subject RIV: FH - Neurology

  8. TU-EF-204-02: Hiigh Quality and Sub-MSv Cerebral CT Perfusion Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Li, Ke; Niu, Kai; Wu, Yijing; Chen, Guang-Hong [University of Wisconsin, Madison, WI (United States)

    2015-06-15

    Purpose: CT Perfusion (CTP) imaging is of great importance in acute ischemic stroke management due to its potential to detect hypoperfused yet salvageable tissue and distinguish it from definitely unsalvageable tissue. However, current CTP imaging suffers from poor image quality and high radiation dose (up to 5 mSv). The purpose of this work was to demonstrate that technical innovations such as Prior Image Constrained Compressed Sensing (PICCS) have the potential to address these challenges and achieve high quality and sub-mSv CTP imaging. Methods: (1) A spatial-temporal 4D cascaded system model was developed to indentify the bottlenecks in the current CTP technology; (2) A task-based framework was developed to optimize the CTP system parameters; (3) Guided by (1) and (2), PICCS was customized for the reconstruction of CTP source images. Digital anthropomorphic perfusion phantoms, animal studies, and preliminary human subject studies were used to validate and evaluate the potentials of using these innovations to advance the CTP technology. Results: The 4D cascaded model was validated in both phantom and canine stroke models. Based upon this cascaded model, it has been discovered that, as long as the spatial resolution and noise properties of the 4D source CT images are given, the 3D MTF and NPS of the final CTP maps can be analytically derived for a given set of processing methods and parameters. The cascaded model analysis also identified that the most critical technical factor in CTP is how to acquire and reconstruct high quality source images; it has very little to do with the denoising techniques often used after parametric perfusion calculations. This explained why PICCS resulted in a five-fold dose reduction or substantial improvement in image quality. Conclusion: Technical innovations generated promising results towards achieving high quality and sub-mSv CTP imaging for reliable and safe assessment of acute ischemic strokes. K. Li, K. Niu, Y. Wu: Nothing to disclose. G.-H. Chen: Research funded, GE Healthcare; Research funded, Siemens AX.

  9. "Ishica, de quien sos tu?": Nostalgia for a Mother Tongue in Rosa Nissan's Novels

    Science.gov (United States)

    Linhard, Tabea Alex

    2009-01-01

    This paper explores the use of Judeo-Spanish in the Rosa Nissan's novels "Novia que te vea" (1992) and "Hisho que te nazca" (1996) and reveals the ways in which the presence of this language interrupts the otherwise linear coming-of-age narrative. An analysis of the main character's relationship with Judeo-Spanish establishes a critical dialogue…

  10. Standardization of quality control plans for highway bridges in Europe: COST Action TU 1406

    Science.gov (United States)

    Casas, Joan R.; Matos, Jose Campos e.

    2017-09-01

    In Europe, as all over the world, the need to manage roadway bridges in an efficient way led to the development of different management systems. Hence, nowadays, many European countries have their own system. Although they present a similar architectural framework, several differences can be appointed. These differences constitute a divergent mechanism that may conduct to different decisions on maintenance actions. Within the roadway bridge management process, the identification of maintenance needs is more effective when developed in a uniform and repeatable manner. This process can be accomplished by the identification of performance indicators and definition of performance goals and key performance indicators (KPI), improving the planning of maintenance strategies. Therefore, a discussion at a European level, seeking to achieve a standardized approach in this subject, will bring significant benefits. Accordingly, a COST Action is under way in Europe with the aim of standardizing the establishment of quality control plans for roadway bridges.

  11. TU-G-207-01: CT Imaging Using Energy-Sensitive Photon-Counting Detectors

    International Nuclear Information System (INIS)

    Taguchi, K.

    2015-01-01

    Last few years has witnessed the development of novel of X-ray imaging modalities, such as spectral CT, phase contrast CT, and X-ray acoustic/fluorescence/luminescence imaging. This symposium will present the recent advances of these emerging X-ray imaging modalities and update the attendees with knowledge in various related topics, including X-ray photon-counting detectors, X-ray physics underlying the emerging applications beyond the traditional X-ray imaging, image reconstruction for the novel modalities, characterization and evaluation of the systems, and their practical implications. In addition, the concept and practical aspects of X-ray activatable targeted nanoparticles for molecular X-ray imaging will be discussed in the context of X-ray fluorescence and luminescence CT. Learning Objectives: Present background knowledge of various emerging X-ray imaging techniques, such as spectral CT, phase contrast CT and X-ray fluorescence/luminescence CT. Discuss the practical need, technical aspects and current status of the emerging X-ray imaging modalities. Describe utility and future impact of the new generation of X-ray imaging applications

  12. Kde se vzal-tu se vzal-sociální kapitál

    Czech Academy of Sciences Publication Activity Database

    Vajdová, Zdenka

    2007-01-01

    Roč. 5, č. 2 (2007), s. 1-2 ISSN 1214-1720 R&D Projects: GA MŠk 2D06006 Institutional research plan: CEZ:AV0Z70280505 Keywords : social capital * research network * bibliographical data Subject RIV: AO - Sociology, Demography www.socioweb.cz

  13. TU-G-BRB-04: Digital Phantoms for Developing Protocols in Particle Therapy

    International Nuclear Information System (INIS)

    Lee, C.

    2015-01-01

    Proton therapy, in particular, and ion therapy, just beginning, are becoming an increasing focus of attention in clinical radiation oncology and medical physics. Both modalities have been criticized of lacking convincing evidence from randomized trials proving their efficacy, justifying the higher costs involved in these therapies. This session will provide an overview of the current status of clinical trials in proton therapy, including recent developments in ion therapy. As alluded to in the introductory talk by Dr. Schulte, opinions are diverging widely as to the usefulness and need for clinical trials in particle therapy and the challenge of equipoise. The lectures will highlight some of the challenges that surround clinical trials in particle therapy. One, presented by Dr. Choy from UT Southwestern, is that new technology and even different types of particles such as helium and carbon ions are introduced into this environment, increasing the phase space of clinical variables. The other is the issue of medical physics quality assurance with physical phantoms, presented by Mrs. Taylor from IROC Houston, which is more challenging because 3D and 4D image guidance and active delivery techniques are in relatively early stages of development. The role of digital phantoms in developing clinical treatment planning protocols and as a QA tool will also be highlighted by Dr. Lee from NCI. The symposium will be rounded off by a panel discussion among the Symposium speakers, arguing pro or con the need and readiness for clinical trials in proton and ion therapy. Learning Objectives: To get an update on the current status of clinical trials allowing or mandating proton therapy. Learn about the status of planned clinical trials in the U.S. and worldwide involving ion therapy. Discuss the challenges in the design and QA of clinical trials in particle therapy. Learn about existing and future physical and computational anthropomorphic phantoms for charged particle clinical trial development and support. Research reported in this presentation is supported by the National Cancer Institute of the National; Institutes of Health under Award Number P20CA183640

  14. TU-F-BRB-03: Clinical Implementation of MR-Based Motion Management

    Energy Technology Data Exchange (ETDEWEB)

    Glide-Hurst, C. [Henry Ford Health System (United States)

    2015-06-15

    The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

  15. Pakend - kaunis ja tüütu lisand / Villem Loigom

    Index Scriptorium Estoniae

    Loigom, Villem

    2007-01-01

    Piimapaki, suitsu- ja parfüümipakendite ajaloost ja tänapäevast. Paberist pudeli looja oli John Van Wormer, Marlboro tänapäevase sigaretipaki disainer oli Francesco Gianninoto ja üheks nimekamaks parfüümipudelite kujundajaks Fabien Baron

  16. TU-A-17A-01: Memorial to Benjamin M. Galkin - Memorial Lecture

    International Nuclear Information System (INIS)

    Suntharalingam, N

    2014-01-01

    This past year Medical Physics lost one of its active members, Benjamin M. Galkin. Ben Galkin was a Past-Treasurer of the AAPM. During his leadership role he played an important part in Securing membership, for the AAPM, in the American Institute of physics. As Treasurer he was also a prime mover in starting the journal, Medical Physics, and served as its business manager in the formative years.Ben Galkin received his Masters Degree at Columbia University in New York, under the mentorship of Dr. Edith Quimby, one of the pioneer Hospital Radiation Physicists in the country. He started his professional career at Jefferson Hospital in Philadelphia, joining Robert Gorson, and remained there until retirement. He served as the institution’s Radiation Safety Officer throughout his career. His research interest was Breast Imaging. He held joint faculty appointments in the Department of Radiology and the Department of Radiation Therapy and Nuclear Medicine, rising up to the rank of Full professor. He was a well respected teacher for the residents in Radiology

  17. DNA Barcoding for Identification of "Candidatus Phytoplasmas" Using a Fragment of the Elongation Factor Tu Gene

    DEFF Research Database (Denmark)

    Makarova, Olga; Contaldo, Nicoletta; Paltrinieri, Samanta

    2012-01-01

    barcoding gap. The use of the tuf barcode allowed separation of main ribosomal groups and most of their subgroups. Phytoplasma tuf barcodes were deposited in the NCBI GenBank and Q-bank databases. Conclusions/Significance This study demonstrates that DNA barcoding principles can be applied...... by plant health services and researchers for online phytoplasma identification....

  18. TU-G-303-03: Machine Learning to Improve Human Learning From Longitudinal Image Sets

    International Nuclear Information System (INIS)

    Veeraraghavan, H.

    2015-01-01

    ‘Radiomics’ refers to studies that extract a large amount of quantitative information from medical imaging studies as a basis for characterizing a specific aspect of patient health. Radiomics models can be built to address a wide range of outcome predictions, clinical decisions, basic cancer biology, etc. For example, radiomics models can be built to predict the aggressiveness of an imaged cancer, cancer gene expression characteristics (radiogenomics), radiation therapy treatment response, etc. Technically, radiomics brings together quantitative imaging, computer vision/image processing, and machine learning. In this symposium, speakers will discuss approaches to radiomics investigations, including: longitudinal radiomics, radiomics combined with other biomarkers (‘pan-omics’), radiomics for various imaging modalities (CT, MRI, and PET), and the use of registered multi-modality imaging datasets as a basis for radiomics. There are many challenges to the eventual use of radiomics-derived methods in clinical practice, including: standardization and robustness of selected metrics, accruing the data required, building and validating the resulting models, registering longitudinal data that often involve significant patient changes, reliable automated cancer segmentation tools, etc. Despite the hurdles, results achieved so far indicate the tremendous potential of this general approach to quantifying and using data from medical images. Specific applications of radiomics to be presented in this symposium will include: the longitudinal analysis of patients with low-grade gliomas; automatic detection and assessment of patients with metastatic bone lesions; image-based monitoring of patients with growing lymph nodes; predicting radiotherapy outcomes using multi-modality radiomics; and studies relating radiomics with genomics in lung cancer and glioblastoma. Learning Objectives: Understanding the basic image features that are often used in radiomic models. Understanding requirements for reliable radiomic models, including robustness of metrics, adequate predictive accuracy, and generalizability. Understanding the methodology behind radiomic-genomic (’radiogenomics’) correlations. Research supported by NIH (US), CIHR (Canada), and NSERC (Canada)

  19. TU-F-BRE-05: Experimental Determination of K Factor in Small Field Dosimetry

    International Nuclear Information System (INIS)

    Das, I; Akino, Y; Francescon, P

    2014-01-01

    Purpose: Small-field dosimetry is challenging due to charged-particle disequilibrium, source occlusion and more importantly finite size of detectors. IAEA/AAPM has published approach to convert detector readings to dose by k factor. Manufacturers have been trying to provide various types of micro-detectors that could be used in small fields. However k factors depends on detector perturbations and are derived using Monte Carlo simulation. PTW has introduced a microDiamond for small-field dosimetry. An experimental approach is presented to derive the k factor for this detector. Methods: PTW microDiamond is a small volume detector with 1.1 mm radius and 1.0 micron thick synthetic diamond. Output factors were measured from 1×1cm2 to 12×12 cm2 on a Varian machine at various depths using various micro-detectors with published k factors. Dose is calculated as reading * K. Assuming k factor is accurate, output factor should be identical with every micro-detectors. Hence published k values (Francescon et al Med Phys 35, 504-513,2008) were used to covert readings and then output factors were computed. Based on the converged curve from other detectors, k factor for microDiamond was computed versus field size. Results: Traditional output factors as ratio of readings normalized to 10×10 cm2 differ significantly for micro-detectors for fields smaller than 3×3 cm2 which are now being used extensively. When readings are converted to dose, the output factor is independent of detector. Based on this method, k factor for microDiamond was estimated to be nearly constant 0.993±0.007 over varied field sizes. Conclusion: Our method provides a unique opportunity to determine the k factor for any unknown detector. It is shown that even though k factor depends on machine type due to focal spot, however for fields ≥1×1 cm2 this method provides accurate evaluation of k factor. Additionally microDiamond could be used with assumption that k factor is nearly unity

  20. REACTION OF THYMUS TU DPT VACCINATION IN CHILDREN AS ASSESSED BY ULTRASONOGRAPHIC STUDIES

    Directory of Open Access Journals (Sweden)

    O. B. Sirotina

    2010-01-01

    Full Text Available When performing ultrasonography of thymus in young children, we have revealed a specific phenomenon, i.e., a significant increase of thymus size in the children of 4 to 6 months old, having been observed at the terms of vaccination with a combined dyphteria/pertussis/tetanus (DPT vaccine. After examining the dimensions, volume, mass and features of thymic blood flow, we have found that, during the DTP vaccinations, 88.7% of the children exhibit an increase in thymic dimensions, along with higher blood flow rates, as compared with the same indices in unvaccinated children. In 11.3% per cent of the cases, the vascularization of thymus was not altered at all, or did not show any changes. To our mind, these ultrasonic parameters of thymic status represent a regular reaction of a key immune organ to a challenge with bacterial antigens, i.e., being an indicator of the primary immune response to DTP vaccination.