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Sample records for trialist association anita

  1. The Anita Peridotite, New Zealand

    DEFF Research Database (Denmark)

    Czertowicz, Tom; Scott, James; Waight, Tod Earle

    2016-01-01

    The orogenic Anita Peridotite in Fiordland, SW New Zealand, provides an opportunity to examine the composition of a large block of upper mantle exhumed from beneath a Cretaceous arc. This Little studied 1km2 km massif is dominated by spinel-facies harzburgite and dunite. Olivine Mg# of 92–93, spi...

  2. Pollination biology of basal angiosperms (ANITA Grade)

    Science.gov (United States)

    Leonard B. Thien; Peter Bernhardt; Margaret S. Devall; Zhi-Duan Chen; Yi-bo Luo; Jian-Hua Fan; Liang-Chen Yuan; Joseph H. Williams

    2009-01-01

    The fi rst three branches of the angiosperm phylogenetic tree consist of eight families with ~201 species of plants (the ANITA grade). The oldest fl ower fossil for the group is dated to the Early Cretaceous (115 – 125 Mya) and identifi ed to the Nymphaeales. The fl owers of extant plants in the ANITA grade are small, and pollen is the edible reward (rarely nectar or...

  3. Pollination biology of basal angiosperms (ANITA grade).

    Science.gov (United States)

    Thien, Leonard B; Bernhardt, Peter; Devall, Margaret S; Chen, Zhi-Duan; Luo, Yi-Bo; Fan, Jian-Hua; Yuan, Liang-Chen; Williams, Joseph H

    2009-01-01

    The first three branches of the angiosperm phylogenetic tree consist of eight families with ∼201 species of plants (the ANITA grade). The oldest flower fossil for the group is dated to the Early Cretaceous (115-125 Mya) and identified to the Nymphaeales. The flowers of extant plants in the ANITA grade are small, and pollen is the edible reward (rarely nectar or starch bodies). Unlike many gymnosperms that secrete "pollination drops," ANITA-grade members examined thus far have a dry-type stigma. Copious secretions of stigmatic fluid are restricted to the Nymphaeales, but this is not nectar. Floral odors, floral thermogenesis (a resource), and colored tepals attract insects in deceit-based pollination syndromes throughout the first three branches of the phylogenetic tree. Self-incompatibility and an extragynoecial compitum occur in some species in the Austrobaileyales. Flies are primary pollinators in six families (10 genera). Beetles are pollinators in five families varying in importance as primary (exclusive) to secondary vectors of pollen. Bees are major pollinators only in the Nymphaeaceae. It is hypothesized that large flowers in Nymphaeaceae are the result of the interaction of heat, floral odors, and colored tepals to trap insects to increase fitness.

  4. Initial Results from the ANITA 2006-2007 Balloon Flight

    Energy Technology Data Exchange (ETDEWEB)

    Gorham, P.W.; /Hawaii U.; Allison, P.; /Hawaii U.; Barwick, S.W.; /UC, Irvine; Beatty, J.J.; /Ohio State U.; Besson, D.Z.; /Kansas U.; Binns, W.R.; /Washington U., St. Louis; Chen, C.; /SLAC; Chen, P.; /SLAC; Clem, J.M.; /Delaware U.; Connolly, A.; /University Coll. London; Dowkontt, P.F.; /Washington U., St. Louis; DuVernois, M.A.; /Minnesota U.; Field, R.C.; /SLAC; Goldstein, D.; /UC, Irvine; Goodhue, A.; /UCLA; Hast, C.; /SLAC; Hebert, C.L.; /Hawaii U.; Hoover, S.; /UCLA; Israel, M.H.; /Washington U., St. Louis; Kowalski, J.; /Hawaii U.; Learned, J.G.; /Hawaii U. /Caltech, JPL /Hawaii U. /Minnesota U. /Hawaii U. /Ohio State U. /Hawaii U. /Hawaii U. /UC, Irvine /Taiwan, Natl. Taiwan U. /Caltech, JPL /SLAC /University Coll. London /Ohio State U. /SLAC /Hawaii U. /Hawaii U. /Hawaii U. /UCLA /Delaware U. /Hawaii U. /SLAC /Taiwan, Natl. Taiwan U. /UC, Irvine

    2011-11-16

    We report initial results of the Antarctic Impulsive Transient Antenna (ANITA) 2006-2007 Long Duration Balloon flight, which searched for evidence of the flux of cosmogenic neutrinos. ANITA flew for 35 days looking for radio impulses that might be due to the Askaryan effect in neutrino-induced electromagnetic showers within the Antarctic ice sheets. In our initial high-threshold robust analysis, no neutrino candidates are seen, with no physics background. In a non-signal horizontal-polarization channel, we do detect 6 events consistent with radio impulses from extensive air showers, which helps to validate the effectiveness of our method. Upper limits derived from our analysis now begin to eliminate the highest cosmogenic neutrino models.

  5. Estimating the adoption of transcatheter aortic valve replacement by US interventional cardiologists and clinical trialists.

    Science.gov (United States)

    Stolker, Joshua M; Patel, Akshar Y; Lim, Michael J; Hauptman, Paul J

    2013-11-01

    Despite extensive attention dedicated to transcatheter aortic valve replacement (TAVR) in both the medical literature and lay press, little is known about the anticipated utilization of TAVR by the US cardiology community. TAVR use is likely to outstrip its initial clinical indications. Four days after approval of the first TAVR device in November 2011 by the US Food and Drug Administration, we emailed an online questionnaire to 201 authors of major TAVR clinical trials (trialists) and 461 recent members of an interventional cardiology professional society (clinicians). Responses were compared using χ(2) , t tests, and analysis of variance. Of 205 surveys received (response rate 31%; 114 clinicians, 91 trialists), the majority of respondents were interventionalists (86%) working in academic practices (72%). Although most physicians anticipated referring optimism for TAVR acceptance in the United States., with more conservative expectations regarding training, procedural volume requirements, and anticipated referral patterns among TAVR trialists than clinical interventionalists. © 2013 Wiley Periodicals, Inc.

  6. Guy ja Anita kõnelevad kaladega kui omasugustega / Kristel Kossar

    Index Scriptorium Estoniae

    Kossar, Kristel

    2005-01-01

    22.-25.09. 2005 toimuvalt Matsalu III rahvusvaheliselt loodusfilmide festivalilt Lihulas. Inglise-prantsuse merebioloogide-allveefilmide autorite Anita ja Guy Chaumette'i filmid "Täiuslik riff" ja "Räägime kaladega"

  7. ANITA Air Monitoring on the International Space Station: Results Compared to Other Measurements

    Science.gov (United States)

    Honne, A.; Schumann-Olsen, H.; Kaspersen, K.; Limero, T.; Macatangay, A.; Mosebach, H.; Kampf, D.; Mudgett, P. D.; James, J. T.; Tan, G.; hide

    2009-01-01

    ANITA (Analysing Interferometer for Ambient Air) is a flight experiment precursor for a permanent continuous air quality monitoring system on the ISS (International Space Station). For the safety of the crew, ANITA can detect and quantify quasi-online and simultaneously 33 gas compounds in the air with ppm or sub-ppm detection limits. The autonomous measurement system is based on FTIR (Fourier Transform Infra-Red spectroscopy). The system represents a versatile air quality monitor, allowing for the first time the detection and monitoring of trace gas dynamics in a spacecraft atmosphere. ANITA operated on the ISS from September 2007 to August 2008. This paper summarizes the results of ANITA s air analyses with emphasis on comparisons to other measurements. The main basis of comparison is NASA s set of grab samples taken onboard the ISS and analysed on ground applying various GC-based (Gas Chromatography) systems.

  8. Anita Hill/Clarence Thomas Revisited: Emotionality as a Necessary Component of Credibility

    Science.gov (United States)

    Sigal, Janet; And Others

    In the years since the Anita Hill/Clarence Thomas Senate Confirmation hearings, it is apparent that this event has had some far-reaching consequences. Although the immediate outcome of the Senate hearings was not positive for Professor Hill, the effect of her testimony seems to have been to encourage more discussion of sexual harassment. The…

  9. Heldentum und Heroisierungsstrategien in Alberto Rondallis Film ‚Anita e Garibaldi‘

    Directory of Open Access Journals (Sweden)

    Robert Lukenda

    2016-06-01

    Full Text Available Der folgende Beitrag rezensiert den 2013 erschienenen Film Anita e Garibaldi vor dem Hintergrund eines zumindest in Italien vorherrschenden gesellschaftlichen Klimas, in dem der italienische Nationalheld sich zwar weiterhin einer hohen Medienpräsenz erfreut, aber längst zum Gegenstand ideologisch konnotierter Vergangenheitsdebatten avanciert ist. Wie zu sehen sein wird, lehnt sich der Film, in dessen Mittelpunkt Garibaldis Heldentaten in Südamerika und die Beziehungsgeschichte zwischen dem Revolutionär und seiner späteren Frau Anita stehen, in seiner Verstrickung intimer Begebenheiten mit dem Wirken auf der großen historischen Bühne dezidiert an Garibaldis eigene Sicht der Dinge an, die dieser selbst in seinen Memoiren an den Tag gelegt hatte.

  10. DIASPORIC HISTORY AND TRANSNATIONAL NETWORKS IN ANITA DESAI’S BAUMGARTNER’S BOMBAY

    Directory of Open Access Journals (Sweden)

    Lucio De Capitani

    2015-11-01

    Full Text Available Anita Desai’s Baumgartner’s Bombay adopts the perspective of a German Jewish Holocaust survivor and of a former cabaret performer to connect the histories of Germany and India. This paper examines how these characters – witnesses to a multiplicity of stories and receptacles of a variety of cultural instances – engender a diasporic network that dismantles the solidity of official history and grants a meaning to the desolate experience of exile.

  11. Tropical, de Anita Malfatti: reorientando uma velha questão

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    Tadeu Chiarelli

    2008-03-01

    Full Text Available A partir da análise de Tropical, tela pintada por Anita Malfatti em 1917, este artigo propõe que a artista procedia a uma mudança em sua linguagem pictórica, afastando-se das concepções de vanguarda que adotara até então para, aderindo ao clima de retorno à ordem internacional, aproximar-se das discussões sobre o nacionalismo na arte, presentes na cena paulistana. Assim, a imagem de mulher insegura que mudou sua perspectiva por causa da crítica de Monteiro Lobato adquire outra conotação. Os modernistas teriam preferido essa interpretação a efetuar uma análise da obra de Anita Malfatti, por meio da qual se poderia desvelar uma deserção do programa vanguardista feita de forma consciente pela artista.Looking back at the issue of a lecture given at Pinacoteca do Estado (São Paulo, Brazil in 2003, this article, based on the analysis of Tropical, canvas painted by Anita Malfatti in 1917, proposes that the artist, contrary to what has traditionally been stated, was undergoing a change in her pictorial language, distancing herself from the vanguard conceptions she had been embracing up to that date. In so doing, she would align with the international trend of the Rappel à l'ordre and approach the discussions on nationalism in art, present in the art millieu of São Paulo city. Thus, the image of an insecure woman who changed her perspective because of the famous review by Monteiro Lobato, acquires another connotation. Modernists would have preferred, and reiterated, this interpretation instead of making an analysis of Anita Malfatti's work per se, through which a volunteer desertion from the vanguard program could be unveiled.

  12. Pahoin vaurioituneen puuvillakankaalle maalatun teoksen konservointi : Konservointikohteena Anita Snellman Vedenkantajan perhe, 1959

    OpenAIRE

    Belinskij, Susanna

    2016-01-01

    Opinnäytetyön konservointikohteena oli Anita Snellmanin öljymaalaus Vedenkantajan perhe vuodelta 1959. Snellman maalasi teoksen Ibizalla. Teos on kuulunut Valtion taideteostoimikunnan kokoelmaan ja ollut sijoitettuna Voioinmaan lukiossa Jyväskylässä. Vedenkantajan perhe on maalattu teollisesti pohjustetulle puuvillakankaalle. Maalauksen kangas on ohut ja harvaan kudottu. Pohjustus sisältää synteettistä sideainetta. Maalipinnan paksuus on vaihteleva; siinä on mattaa ohutta maalipintaa ja ...

  13. Antarctic Surface Reflectivity Measurements from the ANITA-3 and HiCal-1 Experiments

    Science.gov (United States)

    Gorham, P. W.; Allison, P.; Banerjee, O.; Beatty, J. J.; Belov, K.; Besson, D. Z.; Binns, W. R.; Bugaev, V.; Cao, P.; Chen, C.; Chen, P.; Clem, J. M.; Connolly, A.; Dailey, B.; Dasgupta, P.; Deaconu, C.; Cremonesi, L.; Dowkontt, P. F.; Fox, B. D.; Gordon, J.; Hill, B.; Hupe, R.; Israel, M. H.; Jain, P.; Kowalski, J.; Lam, J.; Learned, J. G.; Liewer, K. M.; Liu, T. C.; Matsuno, S.; Miki, C.; Mottram, M.; Mulrey, K.; Nam, J.; Nichol, R. J.; Novikov, A.; Oberla, E.; Prohira, S.; Rauch, B. F.; Romero-Wolf, A.; Rotter, B.; Ratzlaff, K.; Russell, J.; Saltzberg, D.; Seckel, D.; Schoorlemmer, H.; Stafford, S.; Stockham, J.; Stockham, M.; Strutt, B.; Tatem, K.; Varner, G. S.; Vieregg, A. G.; Wissel, S. A.; Wu, F.; Young, R.

    The primary science goal of the NASA-sponsored ANITA project is measurement of ultra-high energy neutrinos and cosmic rays, observed via radio-frequency signals resulting from a neutrino or cosmic ray interaction with terrestrial matter (e.g. atmospheric or ice molecules). Accurate inference of the energies of these cosmic rays requires understanding the transmission/reflection of radio wave signals across the ice-air boundary. Satellite-based measurements of Antarctic surface reflectivity, using a co-located transmitter and receiver, have been performed more-or-less continuously for the last few decades. Our comparison of four different reflectivity surveys, at frequencies ranging from 2 to 45GHz and at near-normal incidence, yield generally consistent maps of high versus low reflectivity, as a function of location, across Antarctica. Using the Sun as an RF source, and the ANITA-3 balloon borne radio-frequency antenna array as the RF receiver, we have also measured the surface reflectivity over the interval 200-1000MHz, at elevation angles of 12-30∘. Consistent with our previous measurement using ANITA-2, we find good agreement, within systematic errors (dominated by antenna beam width uncertainties) and across Antarctica, with the expected reflectivity as prescribed by the Fresnel equations. To probe low incidence angles, inaccessible to the Antarctic Solar technique and not probed by previous satellite surveys, a novel experimental approach (“HiCal-1”) was devised. Unlike previous measurements, HiCal-ANITA constitute a bi-static transmitter-receiver pair separated by hundreds of kilometers. Data taken with HiCal, between 200 and 600MHz shows a significant departure from the Fresnel equations, constant with frequency over that band, with the deficit increasing with obliquity of incidence, which we attribute to the combined effects of possible surface roughness, surface grain effects, radar clutter and/or shadowing of the reflection zone due to Earth

  14. Past Cultural Restrictions in Anita Rau Badami's "Can You Hear the Night Bird Call?" and "'Tamarind Mem"

    Science.gov (United States)

    Johny, S.

    2014-01-01

    The objective of the thesis is to bring out the trauma of the immigrants who are stuck up by the nostalgic and glorious past in their alien world. The cultural and social restrictions faced by the characters who live in their separate but intertwined worlds are brought in a detailed manner. Anita Rau Badami, one of the newest writers in the field…

  15. Energy and flux measurements of ultra-high energy cosmic rays observed during the first ANITA flight

    Energy Technology Data Exchange (ETDEWEB)

    Schoorlemmer, H.; Belov, K.; Romero-Wolf, A.; García-Fernández, D.; Bugaev, V.; Wissel, S. A.; Allison, P.; Alvarez-Muñiz, J.; Barwick, S. W.; Beatty, J. J.; Besson, D. Z.; Binns, W. R.; Carvalho Jr., W. R.; Chen, C.; Chen, P.; Clem, J. M.; Connolly, A.; Dowkontt, P. F.; DuVernois, M. A.; Field, R. C.; Goldstein, D.; Gorham, P. W.; Hast, C.; Huege, T.; Heber, C. L.; Hoover, S.; Israel, M. H.; Javaid, A.; Kowalski, J.; Lam, J.; Learned, J. G.; Link, J. T.; Lusczek, E.; Matsuno, S.; Mercurio, B. C.; Miki, C.; Miočinović, P.; Mulrey, K.; Nam, J.; Naudet, C. J.; Ng, J.; Nichol, R. J.; Palladino, K.; Rauch, B. F.; Roberts, J.; Reil, K.; Rotter, B.; Rosen, M.; Ruckman, L.; Saltzberg, D.; Seckel, D.; Urdaneta, D.; Varner, G. S.; Vieregg, A. G.; Walz, D.; Wu, F.; Zas, E.

    2016-04-01

    The first flight of the Antarctic Impulsive Transient Antenna (ANITA) experiment recorded 16 radio signals that were emitted by cosmic-ray induced air showers. The dominant contribution to the radiation comes from the deflection of positrons and electrons in the geomagnetic field, which is beamed in the direction of motion of the air shower. For 14 of these events, this radiation is reflected from the ice and subsequently detected by the ANITA experiment at a flight altitude of ~36 km. In this paper, we estimate the energy of the 14 individual events and find that the mean energy of the cosmic-ray sample is 2.9 × 1018 eV, which is significantly lower than the previous estimate. By simulating the ANITA flight, we calculate its exposure for ultra-high energy cosmic rays. We estimate for the first time the cosmic-ray flux derived only from radio observations and find agreement with measurements performed at other observatories. In addition, we find that the ANITA data set is consistent with Monte Carlo simulations for the total number of observed events and with the properties of those events.

  16. Anita Fricek: la pintura contemporánea como mecanismo de crítica institucional

    Directory of Open Access Journals (Sweden)

    Stephen Zepke

    2009-04-01

    Full Text Available Este ensayo formula la pregunta acerca de las relaciones posibles entre el arte contemporáneo y la propuesta estética de Gilles Deleuze. Valiéndose de su propia disyunción, pone en contacto dos asuntos yuxtapuestos: lo “conceptual” y la “sensación”. A partir de esa conexión y a través de la obra pictórica de la artista suiza Anita Fricek, el autor critica la propuesta de estética inmanente de la sensación de Deleuze, y la vincula con el mecanismo de crítica institucional inmerso en la propuesta pictórica-crítica de Fricek.

  17. Individual patient data meta-analysis of acupuncture for chronic pain: protocol of the Acupuncture Trialists' Collaboration

    Directory of Open Access Journals (Sweden)

    Sherman Karen J

    2010-09-01

    Full Text Available Abstract Background The purpose of clinical trials of acupuncture is to help clinicians and patients make decisions about treatment. Yet this is not straightforward: some trials report acupuncture to be superior to sham (placebo acupuncture while others show evidence that acupuncture is superior to usual care but not sham, and still others conclude that acupuncture is no better than usual care. Meta-analyses of these trials tend to come to somewhat indeterminate conclusions. This appears to be because, until recently, acupuncture research was dominated by small trials of questionable quality. The Acupuncture Trialists' Collaboration, a group of trialists, statisticians and other researchers, was established to synthesize patient-level data from several recently published large, high-quality trials. Methods There are three distinct phases to the Acupuncture Trialists Collaboration: a systematic review to identify eligible studies; collation and harmonization of raw data; statistical analysis. To be eligible, trials must have unambiguous allocation concealment. Eligible pain conditions are osteoarthritis; chronic headache (tension or migraine headache; shoulder pain; and non-specific back or neck pain. Once received, patient-level data will undergo quality checks and the results of prior publications will be replicated. The primary analysis will be to determine the effect size of acupuncture. Each trial will be evaluated by analysis of covariance with the principal endpoint as the dependent variable and, as covariates, the baseline score for the principal endpoint and the variables used to stratify randomization. The effect size for acupuncture from each trial - that is, the coefficient and standard error from the analysis of covariance - will then be entered into a meta-analysis. We will compute effect sizes separately for comparisons of acupuncture with sham acupuncture, and acupuncture with no acupuncture control for each pain condition. Other

  18. Insufficient recruitment and premature discontinuation of clinical trials in Switzerland: qualitative study with trialists and other stakeholders.

    Science.gov (United States)

    Briel, Matthias; Elger, Bernice; von Elm, Erik; Satalkar, Priya

    2017-11-29

    Premature discontinuation occurs in about 25% of randomised clinical trials in Switzerland; it mainly affects investigator-initiated trials and is mostly due to problems with recruitment of patients. The aim of this study was to qualitatively investigate reasons for trial discontinuation due to poor patient recruitment and suggestions to address those reasons in the Swiss context. We conducted semi-structured interviews with trialists whose trials were discontinued because of recruitment problems, other experienced trialists, and stakeholders in clinical research in Switzerland. Interviews were audio-recorded, transcribed verbatim, and anonymised. We analysed the transcripts using deductive coding and built up themes that were continuously discussed within the research team. Of 65 invited Swiss trialists and stakeholders, 39 (60%) agreed to be interviewed and contributed to this analysis. We identified four main themes of reasons for poor recruitment: (1) Switzerland has a decentralised healthcare system with many small hospitals and few patients per hospital, many research regulations, no standardisation of medical records across hospitals, and a heterogeneous ethics assessment of study protocols. There is little collaboration of different stakeholders in clinical research and a lack of prioritisation of projects. (2) Limited human and financial resources, especially in the academic setting, compromise research questions and size of clinical trials. When funding is used up this typically triggers discontinuation of already delayed clinical trials. (3) Investigators face underdeveloped research networks and a limited collaborative attitude among clinical researchers. They typically embark on clinical studies with a great deal of optimism but insufficient preparation. (4) Swiss patients have universal health coverage and many treatment options. Negative media coverage of clinical research and a lack of accessible information for patients about ongoing clinical

  19. Residual activity evaluation: a benchmark between ANITA, FISPACT, FLUKA and PHITS codes

    Science.gov (United States)

    Firpo, Gabriele; Viberti, Carlo Maria; Ferrari, Anna; Frisoni, Manuela

    2017-09-01

    The activity of residual nuclides dictates the radiation fields in periodic inspections/repairs (maintenance periods) and dismantling operations (decommissioning phase) of accelerator facilities (i.e., medical, industrial, research) and nuclear reactors. Therefore, the correct prediction of the material activation allows for a more accurate planning of the activities, in line with the ALARA (As Low As Reasonably Achievable) principles. The scope of the present work is to show the results of a comparison between residual total specific activity versus a set of cooling time instants (from zero up to 10 years after irradiation) as obtained by two analytical (FISPACT and ANITA) and two Monte Carlo (FLUKA and PHITS) codes, making use of their default nuclear data libraries. A set of 40 irradiating scenarios is considered, i.e. neutron and proton particles of different energies, ranging from zero to many hundreds MeV, impinging on pure elements or materials of standard composition typically used in industrial applications (namely, AISI SS316 and Portland concrete). In some cases, experimental results were also available for a more thorough benchmark.

  20. Residual activity evaluation: a benchmark between ANITA, FISPACT, FLUKA and PHITS codes

    Directory of Open Access Journals (Sweden)

    Firpo Gabriele

    2017-01-01

    Full Text Available The activity of residual nuclides dictates the radiation fields in periodic inspections/repairs (maintenance periods and dismantling operations (decommissioning phase of accelerator facilities (i.e., medical, industrial, research and nuclear reactors. Therefore, the correct prediction of the material activation allows for a more accurate planning of the activities, in line with the ALARA (As Low As Reasonably Achievable principles. The scope of the present work is to show the results of a comparison between residual total specific activity versus a set of cooling time instants (from zero up to 10 years after irradiation as obtained by two analytical (FISPACT and ANITA and two Monte Carlo (FLUKA and PHITS codes, making use of their default nuclear data libraries. A set of ~40 irradiating scenarios is considered, i.e. neutron and proton particles of different energies, ranging from zero to many hundreds MeV, impinging on pure elements or materials of standard composition typically used in industrial applications (namely, AISI SS316 and Portland concrete. In some cases, experimental results were also available for a more thorough benchmark.

  1. Anita: cultivar de alface de verão para cultivo protegido no solo e em hidroponia 'Anita': a new summer lettuce cultivar suitable for protected cultivation in soil and hydroponics systems

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    Ernani Clarete da Silva

    2009-06-01

    Full Text Available 'Anita' é uma cultivar de alface (Lactuca sativa L. do grupo lisa, de cor verde-clara intensa, cujo desenvolvimento se deu a partir de 1994 no município de Campos dos Goytacazes, RJ. Foi selecionada pelo método genealógico a partir do cruzamento entre as cultivares comerciais Vitória e Brasil 303. As plantas contêm diâmetro médio de cabeça de 55 cm, massa fresca de 700 g e número médio de 55 folhas, conforme resultados de ensaios conduzidos nas quatro estações do ano. Possui resistência ao LMV e ao pendoamento precoce em cultivos de verão. As folhas são grandes, macias, crocrantes e adocicadas, sendo estas características mantidas tanto no cultivo protegido no solo quanto em hidroponia.'Anita' is a lettuce cultivar (Lactuca sativa L. of the loose-leaf group whose leaves are of intense green color. This cv. was developed in Campos dos Goytacazes, Rio de Janeiro State, Brazil, since 1994. "Anita" was selected by the pedigree method through crossings between commercial cultivars Vitória and Brasil 303. After evaluations done during four seasons, there were detected a head mean diameter around 55 cm, average fresh plant weight of 700 g and 55 leaves in average. Plants present resistance to Lettuce Mosaic Virus (LMV and high resistance to bolting in the summer. In both cultivation systems, protected environment or hydroponics, plants present leaves of great size, soft and sweet.

  2. Os talentos e a cultura: a trajetória de Anita Malfatti

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    Denise Rocha Belfort Arantes-Brero

    2016-08-01

    Full Text Available Muito se tem pesquisado sobre os indivíduos dotados e talentosos, havendo, em diversos momentos históricos, preocupação com essa população. No Brasil, uma das primeiras vezes em que se falou disso foi na década de 30, por ocasião da fundação da Sociedade Pestalozzi. Apesar desse interesse crescente, na atualidade, existem poucas pesquisas que versam sobre o tema. Este trabalho visa entender como dotação e talento podem se manifestar e serem reconhecidos pela sociedade e cultura na qual a pessoa está inserida, com base na análise da biografia de Anita Malfatti (1889-1964, pintora expressionista, incompreendida em sua época, por ter introduzido uma forma de pintar que não era reconhecida como arte no Brasil. Neste estudo, será apresentada a teoria de Gagné, bem como o que se pretende nomear com os termos dotação e talento. O grande desafio de nossa sociedade é reconhecer as diferenças e valorizá-las, oferecendo a essas pessoas condições para expressão de suas habilidades, garantindo-lhes plena inserção na vida em sociedade para que se sintam produtivas e autorrealizadas. Precisamos lutar contra a “solidão do fundista”, para que o talentoso não esteja sempre adiante dos demais no aspecto intelectual, mas emocionalmente solitário e incompreendido.

  3. Was the ANITA rooting of the angiosperm phylogeny affected by long-branch attraction? Amborella, Nymphaeales, Illiciales, Trimeniaceae, and Austrobaileya.

    Science.gov (United States)

    Qiu, Y L; Lee, J; Whitlock, B A; Bernasconi-Quadroni, F; Dombrovska, O

    2001-09-01

    Five groups of basal angiosperms, Amborella, Nymphaeales, Illiciales, Trimeniaceae, and Austrobaileya (ANITA), were identified in several recent studies as representing a series of the earliest-diverging lineages of the angiosperm phylogeny. All of these studies except one employed a multigene analysis approach and used gymnosperms as the outgroup to determine the ingroup topology. The high level of divergence between gymnosperms and angiosperms, however, has long been implicated in the difficulty of reconstructing relationships at the base of angiosperm phylogeny using DNA sequences, for fear of long-branch attraction (LBA). In this study, we replaced the gymnosperm sequences from the five-gene matrix (mitochondrial atp1 and matR, plastid atpB and rbcL, and nuclear 18S rDNA) used in our earlier study with four categories of divergent sequences--random sequences with equal base frequencies or equally AT- and GC-rich contents, homopolymers and heteropolymers, misaligned gymnosperm sequences, and aligned lycopod and bryophyte sequences--to evaluate whether the gymnosperms were an appropriate outgroup to angiosperms in our earlier study that identified the ANITA rooting. All 24 analyses performed rooted the angiosperm phylogeny at either Acorus or Alisma (or Alisma-Triglochin-Potamogeton in one case due to use of a slightly different alignment) and placed the monocots as a basal grade, producing genuine LBA results. These analyses demonstrate that the identification of ANITA as the basalmost extant angiosperms was based on historical signals preserved in the gymnosperm sequences and that the gymnosperms were an appropriate outgroup with which to root the angiosperm phylogeny in the multigene sequence analysis. This strategy of evaluating the appropriateness of an outgroup using artificial sequences and a series of outgroups with increments of divergence levels can be applied to investigations of phylogenetic patterns at the bases of other major clades, such as land

  4. La gestión de las políticas sobre los espacios públicos para la infancia en el distrito de Santa Anita

    OpenAIRE

    Torres Saco, José Martín

    2012-01-01

    La tesis titulada GESTIÓN DE LAS POLÍTICAS SOBRE LOS ESPACIOS PÚBLICOS PARA LA INFANCIA EN EL DISTRITO DE SANTA ANITA, que presento como trabajo de investigación para optar el grado de magíster en Gerencia Social, es un trabajo que tiene como esencia describir la preocupación y el estado de promoción del derecho a jugar y a recrearse de niños y niñas en espacios públicos, desde los ámbitos políticos (gobierno local), y sociales (dirigentes, padres y madres), en el distrito de Santa Anita. ...

  5. ANITA-2000 activation code package - updating of the decay data libraries and validation on the experimental data of the 14 MeV Frascati Neutron Generator

    Directory of Open Access Journals (Sweden)

    Frisoni Manuela

    2016-01-01

    Full Text Available ANITA-2000 is a code package for the activation characterization of materials exposed to neutron irradiation released by ENEA to OECD-NEADB and ORNL-RSICC. The main component of the package is the activation code ANITA-4M that computes the radioactive inventory of a material exposed to neutron irradiation. The code requires the decay data library (file fl1 containing the quantities describing the decay properties of the unstable nuclides and the library (file fl2 containing the gamma ray spectra emitted by the radioactive nuclei. The fl1 and fl2 files of the ANITA-2000 code package, originally based on the evaluated nuclear data library FENDL/D-2.0, were recently updated on the basis of the JEFF-3.1.1 Radioactive Decay Data Library. This paper presents the results of the validation of the new fl1 decay data library through the comparison of the ANITA-4M calculated values with the measured electron and photon decay heats and activities of fusion material samples irradiated at the 14 MeV Frascati Neutron Generator (FNG of the NEA-Frascati Research Centre. Twelve material samples were considered, namely: Mo, Cu, Hf, Mg, Ni, Cd, Sn, Re, Ti, W, Ag and Al. The ratios between calculated and experimental values (C/E are shown and discussed in this paper.

  6. Santa Anita: la finca, el feudo y el territorio en la nación imaginada por el personaje Fernando Vallejo Santa Anita: Farm, feud and territory in the nation imagined by the character Fernando Vallejo

    Directory of Open Access Journals (Sweden)

    Alberto Cueva Lobelle

    2010-07-01

    Full Text Available La finca de Santa Anita es un espacio emblemático que aparece constantemente en la narrativa de Fernando Vallejo; a través del recuerdo de la finca podemos observar una cosmovisión, una manera de ver el mundo ligada al territorio dentro de una escritura literaria que constituye una práctica social fuertemente contextualizada. En este sentido, la imaginación puede ser entendida como un acto comprometido con la realidad y por ello se apreciará el mérito de las variaciones ideológicas y políticas de las agencias humanas y sociales que la escritura literaria pone en movimiento. Por tanto, se analizará el texto como un documento en el que la relación con el poder se presenta como un testimonio de la existencia de unas más o menos abiertas relaciones de lucha y conflicto.The farm of Santa Anita is an emblematic place constantly appearing in Fernando Vallejo's narrative. Through the memory of the farm, we see a worldview, a way of seeing the world linked to the region within a literary writing which constitutes a highly contextualized social practice. In this sense, we consider the imagination as an act committed to reality and therefore we will appraise the ideological and political changes of human and social agencies that literary writing set in motion. Therefore, we will analyze the text as a document in which the relationship with power is presented as a testimony of the existence of more or less opened relations of struggle and conflict.

  7. ANITA-IEAF activation code package - updating of the decay and cross section data libraries and validation on the experimental data from the Karlsruhe Isochronous Cyclotron

    Science.gov (United States)

    Frisoni, Manuela

    2017-09-01

    ANITA-IEAF is an activation package (code and libraries) developed in the past in ENEA-Bologna in order to assess the activation of materials exposed to neutrons with energies greater than 20 MeV. An updated version of the ANITA-IEAF activation code package has been developed. It is suitable to be applied to the study of the irradiation effects on materials in facilities like the International Fusion Materials Irradiation Facility (IFMIF) and the DEMO Oriented Neutron Source (DONES), in which a considerable amount of neutrons with energies above 20 MeV is produced. The present paper summarizes the main characteristics of the updated version of ANITA-IEAF, able to use decay and cross section data based on more recent evaluated nuclear data libraries, i.e. the JEFF-3.1.1 Radioactive Decay Data Library and the EAF-2010 neutron activation cross section library. In this paper the validation effort related to the comparison between the code predictions and the activity measurements obtained from the Karlsruhe Isochronous Cyclotron is presented. In this integral experiment samples of two different steels, SS-316 and F82H, pure vanadium and a vanadium alloy, structural materials of interest in fusion technology, were activated in a neutron spectrum similar to the IFMIF neutron field.

  8. A escrita de si como prática de uma literatura menor: cartas de Anita Malfatti a Mário de Andrade Self writing as minor literature: the letters of Anita Malfatti to Mário de Andrade

    Directory of Open Access Journals (Sweden)

    Marilda Ionta

    2011-04-01

    Full Text Available No interior de uma cultura falocêntrica a escrita epistolar foi considerada pelos críticos literários uma literatura menor. Por sua vez, os historiadores entenderam por longos anos as cartas pessoais como uma fonte de pesquisa inapropriada ao conhecimento histórico. Neste texto, procuro positivar a literatura de si oriunda das correspondências originadas no âmbito privado, destacando que essa forma de produção literária pode ser tão transgressiva quanto a denominada "grande literatura", isto é, aquela que visa transpor os limites da linguagem, pois nesse caso específico trata-se de recriar a nós mesmos, de transpor as fronteiras do que somos no espaço intersubjetivo da troca epistolar e da amizade. Assim, interpreto as cartas pessoais da artista plástica paulista Anita Malfatti (1889-1964 endereçadas ao escritor modernista Mário de Andrade (1893-1945 como uma literatura menor, no sentido apontado por Gilles Deleuze e Felix Guattari. Essa escrita de caráter privado está associada à construção de uma escultura de si, de uma estética da existência para usar o conceito formulado por Michel Foucault. Portanto, leio a literatura de si das cartas da artista plástica como uma escritura contra-hegemônica e política, pois nas linhas de suas missivas o enredo que se compõe é o da produção de uma subjetividade feminina autônoma que resiste às subjetivações ligadas à família, ao Estado e à Igreja.In a falogocentric culture letter writing has been considered by literary critics as a minor form of literature. Historians, on their part, have considered personal letters as an inadequate source of historical knowledge. In this text I seek to give positive value to the epistolary literature originating from a private exchange of letters, stressing that this kind of literary production can be as transgressive as the so-called "great literature", i.e. that literature that seeks to transpose the limits of language, since in this

  9. Prevention of cardiovascular disease guided by total risk estimations - challenges and opportunities for practical implementation: highlights of a CardioVascular Clinical Trialists (CVCT) Workshop of the ESC Working Group on CardioVascular Pharmacology and Drug Therapy.

    LENUS (Irish Health Repository)

    Zannad, Faiez

    2011-11-03

    This paper presents a summary of the potential practical and economic barriers to implementation of primary prevention of cardiovascular disease guided by total cardiovascular risk estimations in the general population. It also reviews various possible solutions to overcome these barriers. The report is based on discussion among experts in the area at a special CardioVascular Clinical Trialists workshop organized by the European Society of Cardiology Working Group on Cardiovascular Pharmacology and Drug Therapy that took place in September 2009. It includes a review of the evidence in favour of the \\'treat-to-target\\' paradigm, as well as potential difficulties with this approach, including the multiple pathological processes present in high-risk patients that may not be adequately addressed by this strategy. The risk-guided therapy approach requires careful definitions of cardiovascular risk and consideration of clinical endpoints as well as the differences between trial and \\'real-world\\' populations. Cost-effectiveness presents another issue in scenarios of finite healthcare resources, as does the difficulty of documenting guideline uptake and effectiveness in the primary care setting, where early modification of risk factors may be more beneficial than later attempts to manage established disease. The key to guideline implementation is to improve the quality of risk assessment and demonstrate the association between risk factors, intervention, and reduced event rates. In the future, this may be made possible by means of automated data entry and various other measures. In conclusion, opportunities exist to increase guideline implementation in the primary care setting, with potential benefits for both the general population and healthcare resources.

  10. Participación ciudadana de las mujeres de organizaciones sociales en las localidades de Ate, El Agustino y Santa Anita.

    OpenAIRE

    Trelles Cabrera, Mariela

    2010-01-01

    La tesis analiza la participación de las mujeres de las organizaciones sociales en las localidades limeñas de Ate, El Agustino y Santa Anita. En el marco de la nueva reforma del estado la descentralización que promovió la institucionalidad de la participación ciudadana en los procesos de desarrollo local a partir de un marco normativo de leyes y reformas. La investigación se ubica en el período comprendido que van desde fines del año 2003 hasta comienzos del año 2007. Consid...

  11. “One thing does not exist: Oblivion”. The Poiesis of Everness and the Wildness of Art in Anita Desai’s “The Artist of Disappearance”

    Directory of Open Access Journals (Sweden)

    Daniela Fargione

    2017-11-01

    Full Text Available Anita Desai’s The Artist of Disappearance opens with the first line of “Everness” by Jorge Luis Borges to suggest that nothing can be forgotten except for what is not strong enough to become memory. If oblivion is the main theme of this collection, the eponymous story illustrates the need to preserve (mainly from forgetfulness both cultural and natural artworks. The ethical role of the artist as transmitter of values, together with artistic travail as a tool of preservation are particularly evident in Desai’s reference to Nek Chand’s unauthorized “Rock Garden”. In this article I explore the literary representation of desecrated natural and cultural heritage, postcolonial India’s destruction of naturecultural biodiversity, the decentralization of the human, and the agency of elemental materiality.

  12. One life saved by four prevented recurrencies? Update of the early breast cancer trialists confirms. Postoperative radiotherapy improves survival after breast conserving surgery

    International Nuclear Information System (INIS)

    Sautter-Bihl, M.L.; Budach, W.

    2012-01-01

    The debate about the impact of local control on survival in early breast cancer patients is still going on, in spite of the continuously growing evidence that avoidance of locoregional disease reduces the risk of tumor-specific death. Recently, B. Fisher, one of the pioneers of breast conserving therapy claimed that during the last two decades, as a result of the use of systemic therapy in conjunction with breast conserving surgery and radiation, the incidence of locoregional recurrence has been reduced to a level where further reduction is likely to have little impact on survival. The penultimate meta-analysis of the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) reported the effect of radiotherapy in early breast cancer on recurrence and survival in 2005 and provided the essential message that four prevented local recurrences at 5 years would avoid one breast cancer death in 15 years. The scientific community has eagerly awaited the quinquennial update of the EBCTCG which has now been published. A total of 17 randomized studies comparing postoperative radiotherapy vs. none were analyzed and comprised 7 new studies in addition to follow-up data of from 9 previously reported trials. A total of 10,801 patients with pT1-2 tumors were included, the majority of whom (n=7,287) were node negative, while 1,050 were node positive (2,464 unknown). In contrast to the previous meta-analysis, all patients received breast conserving surgery, consisting of lumpectomy (n=8,422) or more extensive techniques like quadrantectomy or sectoral resection (n= 2,399). The effect of radiotherapy on 10-year recurrences of any type and their relation to the 15-year breast cancer death rate were studied in correlation to various prognostic parameters and treatment characteristics (e.g., surgery, tamoxifen use). Moreover, a subgroup analysis was performed according to low, intermediate, and high initial risk of recurrence, from which the expected absolute benefit was derived by

  13. Santa Anita: la finca, el feudo y el territorio en la nación imaginada por el personaje Fernando Vallejo

    Directory of Open Access Journals (Sweden)

    Alberto Cueva Lobelle

    2011-09-01

    Full Text Available La finca de Santa Anita es un espacio emblemático que aparece constantemente en la narrativa de Fernando Vallejo; a través del recuerdo de la finca podemos observar una cosmovisión, una manera de ver el mundo ligada al territorio dentro de una escritura literaria que constituye una práctica social fuertemente contextualizada. En este sentido, la imaginación puede ser entendida como un acto comprometido con la realidad y por ello se apreciará el mérito de las variaciones ideológicas y políticas de las agencias humanas y sociales que la escritura literaria pone en movimiento. Por tanto, se analizará el texto como un documento en el que la relación con el poder se presenta como un testimonio de la existencia de unas más o menos abiertas relaciones de lucha y conflicto.

  14. A escrita de si como prática de uma literatura menor: cartas de Anita Malfatti a Mário de Andrade

    Directory of Open Access Journals (Sweden)

    Marilda Ionta

    2011-01-01

    Full Text Available http://dx.doi.org/10.1590/S0104-026X2011000100007 No interior de uma cultura falocêntrica a escrita epistolar foi considerada peloscríticos literários uma literatura menor. Por sua vez, os historiadores entenderam por longosanos as cartas pessoais como uma fonte de pesquisa inapropriada ao conhecimento histórico.Neste texto, procuro positivar a literatura de si oriunda das correspondências originadas noâmbito privado, destacando que essa forma de produção literária pode ser tão transgressivaquanto a denominada “grande literatura”, isto é, aquela que visa transpor os limites da linguagem,pois nesse caso específico trata-se de recriar a nós mesmos, de transpor as fronteiras do quesomos no espaço intersubjetivo da troca epistolar e da amizade. Assim, interpreto as cartaspessoais da artista plástica paulista Anita Malfatti (1889-1964 endereçadas ao escritor modernistaMário de Andrade (1893-1945 como uma literatura menor, no sentido apontado por GillesDeleuze e Felix Guattari. Essa escrita de caráter privado está associada à construção de umaescultura de si, de uma estética da existência para usar o conceito formulado por MichelFoucault. Portanto, leio a literatura de si das cartas da artista plástica como uma escrituracontra-hegemônica e política, pois nas linhas de suas missivas o enredo que se compõe é o daprodução de uma subjetividade feminina autônoma que resiste às subjetivações ligadas àfamília, ao Estado e à Igreja.

  15. Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration

    Science.gov (United States)

    Pitcher, Alex; Emberson, Jonathan; Lacro, Ronald V.; Sleeper, Lynn A.; Stylianou, Mario; Mahony, Lynn; Pearson, Gail D.; Groenink, Maarten; Mulder, Barbara J.; Zwinderman, Aeilko H.; De Backer, Julie; De Paepe, Anne M.; Arbustini, Eloisa; Erdem, Guliz; Jin, Xu Yu; Flather, Marcus D.; Mullen, Michael J.; Child, Anne H.; Forteza, Alberto; Evangelista, Arturo; Chiu, Hsin-Hui; Wu, Mei-Hwan; Sandor, George; Bhatt, Ami B.; Creager, Mark A.; Devereux, Richard B.; Loeys, Bart; Forfar, J. Colin; Neubauer, Stefan; Watkins, Hugh; Boileau, Catherine; Jondeau, Guillaume; Dietz, Harry C.; Baigent, Colin

    2015-01-01

    Rationale A number of randomized trials are underway, which will address the effects of angiotensin receptor blockers (ARBs) on aortic root enlargement and a range of other end points in patients with Marfan syndrome. If individual participant data from these trials were to be combined, a meta-analysis of the resulting data, totaling approximately 2,300 patients, would allow estimation across a number of trials of the treatment effects both of ARB therapy and of β-blockade. Such an analysis would also allow estimation of treatment effects in particular subgroups of patients on a range of end points of interest and would allow a more powerful estimate of the effects of these treatments on a composite end point of several clinical outcomes than would be available from any individual trial. Design A prospective, collaborative meta-analysis based on individual patient data from all randomized trials in Marfan syndrome of (i) ARBs versus placebo (or open-label control) and (ii) ARBs versus β-blockers will be performed. A prospective study design, in which the principal hypotheses, trial eligibility criteria, analyses, and methods are specified in advance of the unblinding of the component trials, will help to limit bias owing to data-dependent emphasis on the results of particular trials. The use of individual patient data will allow for analysis of the effects of ARBs in particular patient subgroups and for time-to-event analysis for clinical outcomes. The meta-analysis protocol summarized in this report was written on behalf of the Marfan Treatment Trialists' Collaboration and finalized in late 2012, without foreknowledge of the results of any component trial, and will be made available online (http://www.ctsu.ox.ac.uk/research/meta-trials). PMID:25965707

  16. Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration.

    Science.gov (United States)

    Pitcher, Alex; Emberson, Jonathan; Lacro, Ronald V; Sleeper, Lynn A; Stylianou, Mario; Mahony, Lynn; Pearson, Gail D; Groenink, Maarten; Mulder, Barbara J; Zwinderman, Aeilko H; De Backer, Julie; De Paepe, Anne M; Arbustini, Eloisa; Erdem, Guliz; Jin, Xu Yu; Flather, Marcus D; Mullen, Michael J; Child, Anne H; Forteza, Alberto; Evangelista, Arturo; Chiu, Hsin-Hui; Wu, Mei-Hwan; Sandor, George; Bhatt, Ami B; Creager, Mark A; Devereux, Richard B; Loeys, Bart; Forfar, J Colin; Neubauer, Stefan; Watkins, Hugh; Boileau, Catherine; Jondeau, Guillaume; Dietz, Harry C; Baigent, Colin

    2015-05-01

    A number of randomized trials are underway, which will address the effects of angiotensin receptor blockers (ARBs) on aortic root enlargement and a range of other end points in patients with Marfan syndrome. If individual participant data from these trials were to be combined, a meta-analysis of the resulting data, totaling approximately 2,300 patients, would allow estimation across a number of trials of the treatment effects both of ARB therapy and of β-blockade. Such an analysis would also allow estimation of treatment effects in particular subgroups of patients on a range of end points of interest and would allow a more powerful estimate of the effects of these treatments on a composite end point of several clinical outcomes than would be available from any individual trial. A prospective, collaborative meta-analysis based on individual patient data from all randomized trials in Marfan syndrome of (i) ARBs versus placebo (or open-label control) and (ii) ARBs versus β-blockers will be performed. A prospective study design, in which the principal hypotheses, trial eligibility criteria, analyses, and methods are specified in advance of the unblinding of the component trials, will help to limit bias owing to data-dependent emphasis on the results of particular trials. The use of individual patient data will allow for analysis of the effects of ARBs in particular patient subgroups and for time-to-event analysis for clinical outcomes. The meta-analysis protocol summarized in this report was written on behalf of the Marfan Treatment Trialists' Collaboration and finalized in late 2012, without foreknowledge of the results of any component trial, and will be made available online (http://www.ctsu.ox.ac.uk/research/meta-trials). Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Inconsistencies in Quality of Life Data Collection in Clinical Trials: A Potential Source of Bias? Interviews with Research Nurses and Trialists

    Science.gov (United States)

    Kyte, Derek; Ives, Jonathan; Draper, Heather; Keeley, Thomas; Calvert, Melanie

    2013-01-01

    Background Patient-reported outcomes (PROs), such as health-related quality of life (HRQL) are increasingly used to evaluate treatment effectiveness in clinical trials, are valued by patients, and may inform important decisions in the clinical setting. It is of concern, therefore, that preliminary evidence, gained from group discussions at UK-wide Medical Research Council (MRC) quality of life training days, suggests there are inconsistent standards of HRQL data collection in trials and appropriate training and education is often lacking. Our objective was to investigate these reports, to determine if they represented isolated experiences, or were indicative of a potentially wider problem. Methods And Findings We undertook a qualitative study, conducting 26 semi-structured interviews with research nurses, data managers, trial coordinators and research facilitators involved in the collection and entry of HRQL data in clinical trials, across one primary care NHS trust, two secondary care NHS trusts and two clinical trials units in the UK. We used conventional content analysis to analyze and interpret our data. Our study participants reported (1) inconsistent standards in HRQL measurement, both between, and within, trials, which appeared to risk the introduction of bias; (2), difficulties in dealing with HRQL data that raised concern for the well-being of the trial participant, which in some instances led to the delivery of non-protocol driven co-interventions, (3), a frequent lack of HRQL protocol content and appropriate training and education of trial staff, and (4) that HRQL data collection could be associated with emotional and/or ethical burden. Conclusions Our findings suggest there are inconsistencies in the standards of HRQL data collection in some trials resulting from a general lack of HRQL-specific protocol content, training and education. These inconsistencies could lead to biased HRQL trial results. Future research should aim to develop HRQL guidelines

  18. Inconsistencies in quality of life data collection in clinical trials: a potential source of bias? Interviews with research nurses and trialists.

    Science.gov (United States)

    Kyte, Derek; Ives, Jonathan; Draper, Heather; Keeley, Thomas; Calvert, Melanie

    2013-01-01

    Patient-reported outcomes (PROs), such as health-related quality of life (HRQL) are increasingly used to evaluate treatment effectiveness in clinical trials, are valued by patients, and may inform important decisions in the clinical setting. It is of concern, therefore, that preliminary evidence, gained from group discussions at UK-wide Medical Research Council (MRC) quality of life training days, suggests there are inconsistent standards of HRQL data collection in trials and appropriate training and education is often lacking. Our objective was to investigate these reports, to determine if they represented isolated experiences, or were indicative of a potentially wider problem. We undertook a qualitative study, conducting 26 semi-structured interviews with research nurses, data managers, trial coordinators and research facilitators involved in the collection and entry of HRQL data in clinical trials, across one primary care NHS trust, two secondary care NHS trusts and two clinical trials units in the UK. We used conventional content analysis to analyze and interpret our data. Our study participants reported (1) inconsistent standards in HRQL measurement, both between, and within, trials, which appeared to risk the introduction of bias; (2), difficulties in dealing with HRQL data that raised concern for the well-being of the trial participant, which in some instances led to the delivery of non-protocol driven co-interventions, (3), a frequent lack of HRQL protocol content and appropriate training and education of trial staff, and (4) that HRQL data collection could be associated with emotional and/or ethical burden. Our findings suggest there are inconsistencies in the standards of HRQL data collection in some trials resulting from a general lack of HRQL-specific protocol content, training and education. These inconsistencies could lead to biased HRQL trial results. Future research should aim to develop HRQL guidelines and training programmes aimed at supporting

  19. Inconsistencies in quality of life data collection in clinical trials: a potential source of bias? Interviews with research nurses and trialists.

    Directory of Open Access Journals (Sweden)

    Derek Kyte

    Full Text Available Patient-reported outcomes (PROs, such as health-related quality of life (HRQL are increasingly used to evaluate treatment effectiveness in clinical trials, are valued by patients, and may inform important decisions in the clinical setting. It is of concern, therefore, that preliminary evidence, gained from group discussions at UK-wide Medical Research Council (MRC quality of life training days, suggests there are inconsistent standards of HRQL data collection in trials and appropriate training and education is often lacking. Our objective was to investigate these reports, to determine if they represented isolated experiences, or were indicative of a potentially wider problem.We undertook a qualitative study, conducting 26 semi-structured interviews with research nurses, data managers, trial coordinators and research facilitators involved in the collection and entry of HRQL data in clinical trials, across one primary care NHS trust, two secondary care NHS trusts and two clinical trials units in the UK. We used conventional content analysis to analyze and interpret our data. Our study participants reported (1 inconsistent standards in HRQL measurement, both between, and within, trials, which appeared to risk the introduction of bias; (2, difficulties in dealing with HRQL data that raised concern for the well-being of the trial participant, which in some instances led to the delivery of non-protocol driven co-interventions, (3, a frequent lack of HRQL protocol content and appropriate training and education of trial staff, and (4 that HRQL data collection could be associated with emotional and/or ethical burden.Our findings suggest there are inconsistencies in the standards of HRQL data collection in some trials resulting from a general lack of HRQL-specific protocol content, training and education. These inconsistencies could lead to biased HRQL trial results. Future research should aim to develop HRQL guidelines and training programmes aimed at

  20. Efectos de la aplicación de las estrategias lúdicas en el desarrollo del pensamiento creativo de los estudiantes de comunicación de la Institución Educativa 1256 Alfonso Ugarte del distrito de Santa Anita - 2011

    OpenAIRE

    Berrocal Villegas, Carmen Rosa.

    2013-01-01

    En la presente investigación se estudia el siguiente problema: En qué medida la aplicación de las estrategias lúdicas permite mejorar el desarrollo del pensamiento creativo en los estudiantes de comunicación de la Institución Educativa N° 1256 Alfonso Ugarte del distrito de Santa Anita, 2011. La hipótesis que se formula es: "La aplicación de las estrategias lúdicas permite mejorar el desarrollo del pensamiento creativo en los estudiantes de Comunicación de la Institución Educativa N° 1256 Alf...

  1. Under-reporting of conflicts of interest among trialists

    DEFF Research Database (Denmark)

    Rasmussen, Kristine; Schroll, Jeppe; Gøtzsche, Peter C

    2015-01-01

    OBJECTIVES: To determine the prevalence of conflicts of interest (COIs) among Danish physicians who are authors of clinical drug trial reports and determine the extent of undisclosed COIs in trial publications. DESIGN: Cross-sectional study. SETTING: The 100 most recent drug trial reports...... with at least one Danish non-industry employed physician author published in a journal adhering to the International Committee of Medical Journal Editors' (ICMJE) manuscript guidelines. For each article, two observers independently extracted trial characteristics and the authors' COIs. Disclosed COIs were...... compared to what was registered on the Danish Health and Medicines Authority's public disclosure list. PARTICIPANTS: Trial authors who are Danish physicians. MAIN OUTCOME MEASURES: Number of disclosed and undisclosed COIs. RESULTS: One observer screened 928 articles and two observers assessed 120 articles...

  2. En Équateur, une association de tisserandes contribue à l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 oct. 2010 ... Le centre ne manque pas de tisserandes, affirme Anita Loja, la coordonnatrice des ventes du CACH. Les femmes peuvent même tisser jusqu'à l'aube s'il le faut. Anita Loja, qui a appris son métier de sa mère, fait partie des quelque 30 000 femmes de la province d'Azuay et de la province voisine de Cañar ...

  3. The ACRONYM (Alternatives for Circumvention of Restrictions on Naming BY Trialists of Their Manuscripts) Report.

    Science.gov (United States)

    Nusbaum, Neil J

    2009-06-01

    It is hoped that this commentary may draw attention to the issues raised by the enthusiastic naming of large clinical trials. Although the article is tongue in cheek, the underlying concern is that the names of studies may not, in fact, correspond to the actual results they yield.

  4. A randomized study of pomalidomide vs placebo in persons with myeloproliferative neoplasm-associated myelofibrosis and RBC-transfusion dependence.

    Science.gov (United States)

    Tefferi, A; Al-Ali, H K; Barosi, G; Devos, T; Gisslinger, H; Jiang, Q; Kiladjian, J-J; Mesa, R; Passamonti, F; Ribrag, V; Schiller, G; Vannucchi, A M; Zhou, D; Reiser, D; Zhong, J; Gale, R P

    2017-04-01

    RBC-transfusion dependence is common in persons with myeloproliferative neoplasm (MPN)-associated myelofibrosis. The objective of this study was to determine the rates of RBC-transfusion independence after therapy with pomalidomide vs placebo in persons with MPN-associated myelofibrosis and RBC-transfusion dependence. Two hundred and fifty-two subjects (intent-to-treat (ITT) population) including 229 subjects confirmed by central review (modified ITT population) were randomly assigned (2:1) to pomalidomide or placebo. Trialists and subjects were blinded to treatment allocation. Primary end point was proportion of subjects achieving RBC-transfusion independence within 6 months. One hundred and fifty-two subjects received pomalidomide and 77 placebo. Response rates were 16% (95% confidence interval (CI), 11, 23%) vs 16% (8, 26%; P=0.87). Response in the pomalidomide cohort was associated with ⩽4 U RBC/28 days (odds ratio (OR)=3.1; 0.9, 11.1), age ⩽65 (OR=2.3; 0.9, 5.5) and type of MPN-associated myelofibrosis (OR=2.6; 0.7, 9.5). Responses in the placebo cohort were associated with ⩽4 U RBC/28 days (OR=8.6; 0.9, 82.3), white blood cell at randomization >25 × 10 9 /l (OR=4.9; 0.8, 28.9) and interval from diagnosis to randomization >2 years (OR=4.9; 1.1, 21.9). Pomalidomide was associated with increased rates of oedema and neutropenia but these adverse effects were manageable. Pomalidomide and placebo had similar RBC-transfusion-independence response rates in persons with MPN-associated RBC-transfusion dependence.

  5. The relationship between job insecurity, organisational citizenship behaviours and affective organisational commitment / Anita Caldeira Jorge

    OpenAIRE

    Jorge, Anita Caldeira

    2005-01-01

    During the last few decades economic changes leading to transformations in the labour market have taken place in the industrialised world (Mauno & Kinnunen, 1999). These changes have had to be implemented as a result of economic recession, new information technology, industrial restructuring and accelerated global competition (Hartley, Jacobson, Klandermans & Van Vuuren, 199 1 ; Hellgren, Sverke & Isakson, 1999). South African organisations, to remain competitive in these harsh conditions, ha...

  6. CUP-A New High-Flux Irradiation Position at the ANITA Neutron Facility at TSL

    Czech Academy of Sciences Publication Activity Database

    Prokofiev, A. V.; Passoth, E.; Hjalmarsson, A.; Majerle, Mitja

    2014-01-01

    Roč. 61, č. 4 (2014), s. 1929-1936 ISSN 0018-9499. [European Conference on Radiation and its Effects on Components and Systems (RADECS). Oxford, 23.09.2013-27.09.2013] Institutional support: RVO:61389005 Keywords : accelerated testing * integrated circuit radiation effects * neutron beams * neutron detectors * neutron radiation effects * radiation facilities * single event effects * soft error rates * terrestrial radiation environments * test facilities Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.283, year: 2014

  7. Tuleviku-uuringud kui teadmiste valdkond = Futures studies as a field of knowledge / Anita Rubin

    Index Scriptorium Estoniae

    Rubin, Anita

    2005-01-01

    Tuleviku-uuringute algpunktid. Tuleviku-uuringud kui teaduslik distsipliin. Tuleviku moodustamine olevikust. Bibliograafia lk. 34. Artikli kommentaariks Panu Lehtovuori tuleviku-uuringute meetodite kasutamisest linnauuringutes ja teadusuuringutel põhinevast kavandamisest/disainist

  8. Is there an association between insomnia symptoms, aggressive behavior, and suicidality in adolescents?

    Directory of Open Access Journals (Sweden)

    Zschoche M

    2015-03-01

    Full Text Available Maria Zschoche, Angelika Anita Schlarb Faculty of Psychology and Sports Science, University of Bielefeld, Bielefeld, Germany Purpose: Sleep disturbances are a common problem during adolescence. Often there is a relationship with the mental health of the affected person. The existing literature concerning the link between sleep disturbances and aggressive behavior and sleep disturbances and suicidality during adolescence shows no clear results. The present study tested a mediation model to prove the relation between sleep problems, aggressive behavior, and suicidality during adolescence. To take the link between suicidality and depression into account, the amount of depressive symptoms was included into the mediation model. Methods: A sample of 93 adolescents aged 14–18 years (30% male was studied. A survey was conducted to interview the adolescents about their mental health, sleep-related behaviors, aggressive behavior, and suicidality. Results: Sleep problems and suicidality measures were significantly related to each other. Furthermore, aggressive behavior and suicidality showed a significant relationship. The expected link between sleep problems and aggressive behavior was not significant. For the mediation model, no significant influence of aggressive behavior on the relationship between the amount of sleep problems and suicidality was found. However, the impact of depressive symptoms on the relationship between sleep problems and suicidality was significant. Conclusion: Sleep problems and overall suicidality in adolescents are significantly connected, even after adjusting for several possible influencing factors. Aggressive behavior could not be confirmed as a mediator for the association between sleep problems and suicidality in adolescents. Further studies to examine the link between insomnia symptoms, aggressive behavior, and suicidality in adolescents are necessary. Keywords: adolescents, aggressive behavior, sleep problems

  9. Loss of Consciousness at Onset of Aneurysmal Subarachnoid Hemorrhage is Associated with Functional Outcomes in Good-Grade Patients.

    Science.gov (United States)

    Wang, Justin; Alotaibi, Naif M; Akbar, Muhammad Ali; Ayling, Oliver G S; Ibrahim, George M; Macdonald, R Loch

    2017-02-01

    Transient loss of consciousness (LOC) is one of the most common presentations of aneurysmal subarachnoid hemorrhage (SAH) and may be an indicator of early brain injury. In this study, we examined the association of LOC and functional outcomes in patients with good-grade SAH. We searched the Subarachnoid Hemorrhage International Trialists Repository for patients who presented with LOC at ictus of SAH. A propensity score analysis was performed on good-grade patients (defined as World Federation of Neurosurgical Societies grade 1-3) to balance selected covariates between those with and without LOC. The primary outcome was Glasgow Outcome Score (GOS) at 3 months (with poor outcome defined as a GOS of 1-3). Secondary outcomes were delayed cerebral ischemia (DCI), rebleed, length of hospital stay, and time to death. A propensity score-matching algorithm identified 336 patients (168 with and 168 without LOC at ictus). The proportion of patients with poor functional outcome at 3 months was significantly higher in the cohort with LOC at ictus compared with the matched cohort without LOC at ictus (30% vs. 19%; P = 0.02). There was a nonsignificant trend toward greater mortality in the patients with LOC at ictus (19% vs. 13%; P = 0.14). There were no significant differences in the secondary outcomes between the 2 cohorts. LOC at ictus of SAH is associated with a higher rate of unfavorable functional outcomes but not of mortality, DCI, or rebleed in patients with good-grade SAH. Future studies should further investigate the putative mechanisms through which LOC mediates early brain injury in SAH. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. The Challenges Facing Canadian Trialists in an Increasingly Competitive Global Market: What Can be Done to Remain Competitive?

    Directory of Open Access Journals (Sweden)

    David W Scheifele

    2007-01-01

    Full Text Available Globally, the pharmaceutical industry is condensing into fewer, larger international corporations. This has occurred with the vaccine industry in Canada, where two domestic producers have been absorbed by international companies. This changes the relationship between Canadian vaccine researchers and corporate head office research directors, who carefully assign prelicensure studies to potential market countries around the globe. To succeed in attracting prelicensure vaccine studies, Canadian researchers need to be outstanding in quality, reliability and efficiency. The present article highlights strategies to help researchers remain internationally competitive for industry-sponsored pharmaceutical studies.

  11. The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial.

    Science.gov (United States)

    Barr, Colin; Marois, Maria; Sim, Ida; Schmid, Christopher H; Wilsey, Barth; Ward, Deborah; Duan, Naihua; Hays, Ron D; Selsky, Joshua; Servadio, Joseph; Schwartz, Marc; Dsouza, Clyde; Dhammi, Navjot; Holt, Zachary; Baquero, Victor; MacDonald, Scott; Jerant, Anthony; Sprinkle, Ron; Kravitz, Richard L

    2015-02-27

    Chronic pain is prevalent, costly, and clinically vexatious. Clinicians typically use a trial-and-error approach to treatment selection. Repeated crossover trials in a single patient (n-of-1 trials) may provide greater therapeutic precision. N-of-1 trials are the most direct way to estimate individual treatment effects and are useful in comparing the effectiveness and toxicity of different analgesic regimens. The goal of the PREEMPT study is to test the 'Trialist' mobile health smartphone app, which has been developed to make n-of-1 trials easier to accomplish, and to provide patients and clinicians with tools for individualizing treatments for chronic pain. A randomized controlled trial is being conducted to test the feasibility and effectiveness of the Trialist app. A total of 244 participants will be randomized to either the Trialist app intervention group (122 patients) or a usual care control group (122 patients). Patients assigned to the Trialist app will work with their clinicians to set up an n-of-1 trial comparing two pain regimens, selected from a menu of flexible options. The Trialist app provides treatment reminders and collects data entered daily by the patient on pain levels and treatment side effects. Upon completion of the n-of-1 trial, patients review results with their clinicians and develop a long-term treatment plan. The primary study outcome (comparing Trialist to usual care patients) is pain-related interference with daily functioning at 26 weeks. Trialist will allow patients and clinicians to conduct personalized n-of-1 trials. In prior studies, n-of-1 trials have been shown to encourage greater patient involvement with care, which has in turn been associated with better health outcomes. mHealth technology implemented using smartphones may offer an efficient means of facilitating n-of-1 trials so that more patients can benefit from this approach. ClinicalTrials.gov: NCT02116621 , first registered 15 April 2014.

  12. Microbial Community Diversity in Fault-Associated and Ophiolite-Hosted Springs

    Science.gov (United States)

    Meyer-Dombard, D. R.; Cardace, D.; Uzunlar, N.; Gulecal, Y.; Yargicoglu, E. N.; Carbone, J. N.

    2010-12-01

    Deep biosphere habitats and hydrothermal systems are ideal candidates for analog ecosystems to life on Early Earth and Astrobiological targets. They also likely harbor vast repositories of novel biological and genetic diversity. This study compares the biological and genetic diversity of microbial communities in terrestrial hydrothermal and cool fluid seeps and springs, occuring in both ophiolite-hosted and non-ophiolite sequences. Fluids and solids (biofilms and sediment) with variable fractions of ultramafic-sourced and serpentinizing reaction fluids and mineral fragments were collected from surface seeps and deeply-sourced springs associated with the Northern Anatolian Fault Zone (NAFZ, Turkey) and the Anita Shear Zone (ASZ, New Zealand). Comparisons are drawn between three regimes: 1) cool fluid systems in ophiolite-hosted sequences in NAFZ vs. ASZ, 2) cool fluid vs. hydrothermal fluid systems in the NAFZ, and 3) hydrothermal systems in NAFZ ophiolite-hosted vs. non-ophiolite sequences. These comparisons help differentiate microbial community structure and metabolic strategies between hydrothermal and serpentinizing input to these ecosystems. The integration of geobiological data from these sites clarifies how microbial systems respond to even subtle shifts in geochemistry of the water-rock system, and our consideration of mafic/ultramafic rocks as habitable formations brings new astrobiological relevance to this work. Microbial communities were examined using a suite of culture-dependant and independent methods, co-registered with a network of geochemical contextual samples. Geochemical datasets allow prediction of available sources of energy in these nutrient-limited ecosystems. Sample locations varied in temperature 30-90C and pH 6.5-9.0 Potential sources of energy and carbon include dissolved organic carbon, CO2, sulfide, sulfate, and ferrous iron, depending on the sample location. Enrichments were obtained using a variety of carbon and energy sources, in

  13. Révision de Jane Eyre comme métacommentaire philosophique dans les romans d’Anita Brookner Re-Vision of Jane Eyre as Philosophical Metacomment in the Novels of Anita Brookner

    Directory of Open Access Journals (Sweden)

    Eileen Williams-Wanquet

    2009-10-01

    Full Text Available Although none of Brookner’s twenty-three novels to date actually re-write Jane Eyre as hypotext, Brontë’s novel is part of the pervasive intertextuality of Brookner’s text, addressed here as a monolithic fiction. This omnipresent intertextuality, which is the key to understanding the whole œuvre, serves to define the moral codes followed by the heroine and to make a philosophical metacommentary on contemporary culture. Brookner’s characters read and comment on Jane Eyre, the heroine takes Jane as a role model of virtue and the masculine characters are divided into those who resemble Mr Rochester and those who belong to the same category as St John Rivers. But Brookner’s text is a re-vision of Brontë’s novel, as of other novels set in the tradition of the classic realist text and of romance, which have Cartesian rationalism and Christianity as philosophical underpinnings. Brookner reverses the poetic justice of Jane Eyre, which is re-contextualised to fit a new moral landscape in which God is dead as ultimate justification for virtuous conduct. Whereas Jane Eyre can ultimately be read as a “Victorian romance” which preaches reason in the name of social order, by replacing the traditional happy ending by an unhappy ending in which virtue is punished and by foregrounding the disastrous effects of suppressing passion in the name of reason or self in the name of the other, Brookner announces the end of a philosophical humanistic tradition in which the subject / object or self / other opposition gives rise to a host of binary oppositions, the notion of centre validating the dominance of one of the terms of the hierarchy.

  14. Elephants for Mr. Lincoln: American Civil War-Era Diplomacy in Southeast Asia, William Strobridge & Anita Hibler

    Directory of Open Access Journals (Sweden)

    Adela Baer

    2012-11-01

    Full Text Available This curious book, which begins with events in the 1810s, emphasizes Burma and Siam but undervalues other parts of Southeast Asia. The title refers to the offer by the king of Siam to send elephants to the United States to help President Lincoln win the Civil War. The book rightly discusses commerce, diplomats, and military actions in Southeast Asia. Missionaries are, for unclear reasons, also given prominence; in fact, much of the authors’ information comes from Protestant missionary sources...

  15. Association between age and risk of stroke or death from carotid endarterectomy and carotid stenting: a meta-analysis of pooled patient data from four randomised trials.

    Science.gov (United States)

    Howard, George; Roubin, Gary S; Jansen, Olav; Hendrikse, Jeroen; Halliday, Alison; Fraedrich, Gustav; Eckstein, Hans-Henning; Calvet, David; Bulbulia, Richard; Bonati, Leo H; Becquemin, Jean-Pierre; Algra, Ale; Brown, Martin M; Ringleb, Peter A; Brott, Thomas G; Mas, Jean-Louis

    2016-03-26

    Age was reported to be an effect-modifier in four randomised controlled trials comparing carotid artery stenting (CAS) and carotid endarterectomy (CEA), with better CEA outcomes than CAS outcomes noted in the more elderly patients. We aimed to describe the association of age with treatment differences in symptomatic patients and provide age-specific estimates of the risk of stroke and death within narrow (5 year) age groups. In this meta-analysis, we analysed individual patient-level data from four randomised controlled trials within the Carotid Stenosis Trialists' Collaboration (CSTC) involving patients with symptomatic carotid stenosis. We included only trials that randomly assigned patients to CAS or CEA and only patients with symptomatic stenosis. We assessed rates of stroke or death in 5-year age groups in the periprocedural period (between randomisation and 120 days) and ipsilateral stroke during long-term follow-up for patients assigned to CAS or CEA. We also assessed differences between CAS and CEA. All analyses were done on an intention-to-treat basis. Collectively, 4754 patients were randomly assigned to either CEA or CAS treatment in the four studies. 433 events occurred over a median follow-up of 2·7 years. For patients assigned to CAS, the periprocedural hazard ratio (HR) for stroke and death in patients aged 65-69 years compared with patients younger than 60 years was 2·16 (95% CI 1·13-4·13), with HRs of roughly 4·0 for patients aged 70 years or older. We noted no evidence of an increased periprocedural risk by age group in the CEA group (p=0·34). These changes underpinned a CAS-versus CEA periprocedural HR of 1·61 (95% CI 0·90-2·88) for patients aged 65-69 years and an HR of 2·09 (1·32-3·32) for patients aged 70-74 years. Age was not associated with the postprocedural stroke risk either within treatment group (p≥0·09 for CAS and 0·83 for CEA), or between treatment groups (p=0·84). In these RCTs, CEA was clearly superior to CAS in

  16. Evaluation of implanted gold seeds for breast radiotherapy planning and on treatment verification: A feasibility study on behalf of the IMPORT trialists

    International Nuclear Information System (INIS)

    Coles, Charlotte E.; Harris, Emma J.; Donovan, Ellen M.; Bliss, Peter; Evans, Philip M.; Fairfoul, Jamie; Mackenzie, Christine; Rawlings, Christine; Syndikus, Isabel; Twyman, Nicola; Vasconcelos, Joana; Vowler, Sarah L.; Wilkinson, Jenny S.; Wilks, Robin; Wishart, Gordon C.; Yarnold, John

    2011-01-01

    Background and purpose: We describe a feasibility study testing the use of gold seeds for the identification of post-operative tumour bed after breast conservation surgery (BCS). Materials and Methods: Fifty-three patients undergoing BCS for invasive cancer were recruited. Successful use was defined as all six seeds correctly positioned around the tumour bed during BCS, unique identification of all implanted seeds on CT planning scan and ≥3 seeds uniquely identified at verification to give couch displacement co-ordinates in 10/15 fractions. Planning target volume (PTV) margin size for four correction strategies were calculated from these data. Variability in tumour bed contouring was investigated with five radiation oncologists outlining five CT datasets. Results: Success in inserting gold seeds, identifying them at CT planning and using them for on-treatment verification was recorded in 45/51 (88%), 37/38 (97%) and 42/43 (98%) of patients, respectively. The clinicians unfamiliar with CT breast planning consistently contoured larger volumes than those already trained. Margin size ranged from 10.1 to 1.4 mm depending on correction strategy. Conclusion: It is feasible to implant tumour bed gold seeds during BCS. Whilst taking longer to insert than surgical clips, they have the advantage of visibility for outlining and verification regardless of the ionising radiation beam quality. Appropriate correction strategies enable margins of the order of 5 mm as required by the IMPORT trials however, tackling clinician variability in contouring is important.

  17. [Associative commitments].

    Science.gov (United States)

    Paulet, Marie-Claire

    2017-12-01

    Volunteering to serve the general interest, that is the profession of faith behind associative commitments. Notably, actions by associations undertaken in favour of organ donation today must, in their content and forms, reconcile tradition and modernity. But they keep their driving principles and values intact. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  18. Staff Association

    CERN Multimedia

    Staff Association

    2014-01-01

    Remove of the staff association office   The Staff Association offices are going to be renovated during the coming four months, February to May 2014. The physical move from our current premises 64/R-002 to our temporary office in  510/R-010 will take place on Friday January 31st, so the Secretariat will be closed on that day. Hence, from Monday February 3rd until the end of May 2014 the Staff Association Secretariat will be located in 510/R-010 (entrance just across the CERN Printshop).    

  19. Alzheimer's Association

    Science.gov (United States)

    ... will not share your information. * Required. View archives. Alzheimer's impact is growing Alzheimer's disease is the sixth- ... Last Updated: Our vision is a world without Alzheimer's Formed in 1980, the Alzheimer's Association advances research ...

  20. Aerobic fitness is associated with low cardiovascular disease risk: the impact of lifestyle on early risk factors for atherosclerosis in young healthy Swedish individuals – the Lifestyle, Biomarker, and Atherosclerosis study

    Directory of Open Access Journals (Sweden)

    Fernström M

    2017-03-01

    Full Text Available Maria Fernström,1,* Ulrika Fernberg,2,* Gabriella Eliason,1 Anita Hurtig-Wennlöf1 1Department of Medical Diagnostics, Medical Faculty, School of Health Sciences, 2Medical Faculty, School of Medical Sciences, Örebro University, Örebro, Sweden *These authors contributed equally to this work Background: The progression of cardiovascular disease (CVD and atherosclerosis is slow and develops over decades. In the cross-sectional Swedish Lifestyle, Biomarker, and Atherosclerosis study, 834 young, self-reported healthy adults aged 18.0–25.9 years have been studied to identify early risk factors for atherosclerosis.Purpose: The aims of this study were to 1 assess selected cardiometabolic biomarkers, carotid intima–media thickness (cIMT as a marker of subclinical atherosclerosis, and lifestyle-related indicators (food habits, handgrip strength, and oxygen uptake, VO2 max; 2 analyze the assofciations between cIMT and lifestyle factors; and 3 identify subjects at risk of CVD using a risk score and to compare the characteristics of subjects with and without risk of CVD.Method: Blood samples were taken in a fasting state, and food habits were reported through a questionnaire. cIMT was measured by ultrasound, and VO2 max was measured by ergometer bike test. The risk score was calculated according to Wildman.Result: cIMT (mean ± standard deviation was 0.50±0.06 mm, and VO2 max values were 37.8±8.5 and 42.9±9.9 mL/kg/min, in women and men, respectively. No correlation was found between aerobic fitness expressed as VO2 max (mL/kg/min and cIMT. Using Wildman’s definition, 12% of the subjects were classified as being at risk of CVD, and 15% had homeostasis model assessment of insulin resistance. A total of 35% of women and 25% of men had lower high-density lipoprotein cholesterol than recommended. Food habits did not differ between those at risk and those not at risk. However, aerobic fitness measured as VO2 max (mL/kg/min differed; 47% of the

  1. CHARGE Association

    Directory of Open Access Journals (Sweden)

    Semanti Chakraborty

    2012-01-01

    Full Text Available We present here a case of 17-year-old boy from Kolkata presenting with obesity, bilateral gynecomastia, mental retardation, and hypogonadotrophic hypogonadism. The patient weighed 70 kg and was of 153 cm height. Facial asymmetry (unilateral facial palsy, gynecomastia, decreased pubic and axillary hair, small penis, decreased right testicular volume, non-palpable left testis, and right-sided congenital inguinal hernia was present. The patient also had disc coloboma, convergent squint, microcornea, microphthalmia, pseudohypertelorism, low set ears, short neck, and choanalatresia. He had h/o VSD repaired with patch. Laboratory examination revealed haemoglobin 9.9 mg/dl, urea 24 mg/dl, creatinine 0.68 mg/dl. IGF1 77.80 ng/ml (decreased for age, GH <0.05 ng/ml, testosterone 0.25 ng/ml, FSH-0.95 ΅IU/ml, LH 0.60 ΅IU/ml. ACTH, 8:00 A.M cortisol, FT3, FT4, TSH, estradiol, DHEA-S, lipid profile, and LFT was within normal limits. Prolactin was elevated at 38.50 ng/ml. The patient′s karyotype was 46XY. Echocardiography revealed ventricularseptal defect closed with patch, grade 1 aortic regurgitation, and ejection fraction 67%. Ultrasound testis showed small right testis within scrotal sac and undescended left testis within left inguinal canal. CT scan paranasal sinuses revealed choanalatresia and deviation of nasal septum to the right. Sonomammography revealed bilateral proliferation of fibroglandular elements predominantly in subareoalar region of breasts. MRI of brain and pituitary region revealed markedly atrophic pituitary gland parenchyma with preserved infundibulum and hypothalamus and widened suprasellar cistern. The CHARGE association is an increasingly recognized non-random pattern of congenital anomalies comprising of coloboma, heart defect, choanal atresia, retarded growth and development, genital hypoplasia, ear abnormalities, and/or deafness. [1] These anomalies have a higher probability of occurring together. In this report, we have

  2. Interstitial Cystitis Association

    Science.gov (United States)

    ... frequency? You may have IC. Get The Facts Interstitial Cystitis Association The Interstitial Cystitis Association (ICA) is the ... news and events. Please leave this field empty Interstitial Cystitis Association 7918 Jones Branch Drive, Suite 300 McLean, ...

  3. Marketing and clinical trials: a case study.

    Science.gov (United States)

    Francis, David; Roberts, Ian; Elbourne, Diana R; Shakur, Haleema; Knight, Rosemary C; Garcia, Jo; Snowdon, Claire; Entwistle, Vikki A; McDonald, Alison M; Grant, Adrian M; Campbell, Marion K

    2007-11-20

    Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well, adopting effective marketing strategies. Using methods of analysis drawn from management studies, this paper presents a structured assessment framework or reference model, derived from a case analysis of the MRC's CRASH trial, of 12 factors that may affect the success of the marketing and sales activities associated with clinical trials. The case study demonstrates that trials need various categories of people to buy in - hence, to be successful, trialists must embrace marketing strategies to some extent. The performance of future clinical trials could be enhanced if trialists routinely considered these factors.

  4. Timing is the elusive connector of dreams

    Science.gov (United States)

    Lones, Joe J.; Lones, Lance

    2014-12-01

    Establishing San Diego as the venue for SPIE annual meetings was an activity loaded with unusual efforts and imagination on the part Joe Yaver, his wife, Anita, and some southern California members. Of interest is the origin (and retention) of SPIE as a name for the organization. Few know the associated logo has real technical meaning. Then there was moving SPIE headquarters to Bellingham, Washington, to complicate things.

  5. Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration.

    NARCIS (Netherlands)

    Pitcher, A.; Emberson, J.; Lacro, R.V.; Sleeper, L.A.; Stylianou, M.; Mahony, L.; Pearson, G.D.; Groenink, M.; Mulder, B.J.; Zwinderman, A.H.; Backer, J. De; Paepe, A.M. De; Arbustini, E.; Erdem, G.; Jin, X.Y.; Flather, M.D.; Mullen, M.J.; Child, A.H.; Forteza, A.; Evangelista, A.; Chiu, H.H.; Wu, M.H.; Sandor, G.; Bhatt, A.B.; Creager, M.A.; Devereux, R.B.; Loeys, B.L.; Forfar, J.C.; Neubauer, S.; Watkins, H.; Boileau, C.; Jondeau, G.; Dietz, H.C.; Baigent, C.

    2015-01-01

    RATIONALE: A number of randomized trials are underway, which will address the effects of angiotensin receptor blockers (ARBs) on aortic root enlargement and a range of other end points in patients with Marfan syndrome. If individual participant data from these trials were to be combined, a

  6. American Nephrology Nurses' Association

    Science.gov (United States)

    ... Association About ANNA Association About ANNA Strategic Plan Constitution and Bylaws Organizational Chart Fact Sheet History The ... Jobs Find a Job Information for Advertisers Health Policy Health Policy Health Policy Handbook Resources and Tools ...

  7. Associative Memory Acceptors.

    Science.gov (United States)

    Card, Roger

    The properties of an associative memory are examined in this paper from the viewpoint of automata theory. A device called an associative memory acceptor is studied under real-time operation. The family "L" of languages accepted by real-time associative memory acceptors is shown to properly contain the family of languages accepted by one-tape,…

  8. Intended Brand Associations

    DEFF Research Database (Denmark)

    Koll, Oliver; von Wallpach, Sylvia

    2014-01-01

    Brand managers exhibit considerable effort to define intended brand associations to anchor in consumers' minds. They follow a credo deeply rooted in branding literature: intended brand associations drive consumer response and brand equity. This article investigates the benefits of a strong overlap...... of actual consumer brand associations and management-intended brand associations (brand association match). The article presents results from two large-scale studies (3353 and 1201 respondents) involving one consumer goods and one service brand with multiple operationalizations of consumer response...... (attitudinal and behavioral). The results show that consumers with high brand association match show more positive brand response. However, after accounting for the valence of associations match does not add explanatory power. This outcome challenges a key foundation of brand management. The discussion...

  9. Class Association Rule Pada Metode Associative Classification

    Directory of Open Access Journals (Sweden)

    Eka Karyawati

    2011-11-01

    Full Text Available Frequent patterns (itemsets discovery is an important problem in associative classification rule mining.  Differents approaches have been proposed such as the Apriori-like, Frequent Pattern (FP-growth, and Transaction Data Location (Tid-list Intersection algorithm. This paper focuses on surveying and comparing the state of the art associative classification techniques with regards to the rule generation phase of associative classification algorithms.  This phase includes frequent itemsets discovery and rules mining/extracting methods to generate the set of class association rules (CARs.  There are some techniques proposed to improve the rule generation method.  A technique by utilizing the concepts of discriminative power of itemsets can reduce the size of frequent itemset.  It can prune the useless frequent itemsets. The closed frequent itemset concept can be utilized to compress the rules to be compact rules.  This technique may reduce the size of generated rules.  Other technique is in determining the support threshold value of the itemset. Specifying not single but multiple support threshold values with regard to the class label frequencies can give more appropriate support threshold value.  This technique may generate more accurate rules. Alternative technique to generate rule is utilizing the vertical layout to represent dataset.  This method is very effective because it only needs one scan over dataset, compare with other techniques that need multiple scan over dataset.   However, one problem with these approaches is that the initial set of tid-lists may be too large to fit into main memory. It requires more sophisticated techniques to compress the tid-lists.

  10. Antibiotic-Associated Diarrhea

    Science.gov (United States)

    ... antibiotic-associated colitis, which can occur after the antibiotic therapy upsets the balance of good and bad bacteria in your intestinal tract. Besides loose stools, C. difficile infection can ... and symptoms of antibiotic-associated diarrhea. These signs and symptoms are common ...

  11. Unilateral CHARGE association

    NARCIS (Netherlands)

    Trip, J; van Stuijvenberg, M; Dikkers, FG; Pijnenburg, MWH

    A case with a predominantly unilateral CHARGE association is reported. The CHARGE association refers to a combination of congenital malformations. This boy had left-sided anomalies consisting of choanal atresia. coloboma and peripheral facial palsy. The infant had a frontal encephalocele. an anomaly

  12. Prevalence and associated f

    Directory of Open Access Journals (Sweden)

    Wafaa Yousif Abdel Wahed

    2017-03-01

    Conclusion: A substantial proportion of medical students are suffering from depression, stress, and anxiety. Female sex, increasing age, overweight and obesity are significant associated factors. Further studies need to be carried to identify other associated factors related to academic medical education.

  13. Italian Word Association Norms.

    Science.gov (United States)

    1966-07-01

    Ricerche Istituto Nazionale I Psicologia , Roma Italy. A different, but not unrelated, approach is to use word association norms to study other types of... Psicologia , 1961 , 55, 1,13-155. Chiari, S. 11 comportamento associative nell’eta ovolutiva, Rivista di Psicologia , 1 96 1b , 55, 175-189. Cofer, C.N

  14. Staff Association Cocktail

    CERN Multimedia

    Staff Association

    2017-01-01

    The Staff Association has been organising for many years a cocktail with delegates of the Member States participating in Finance Committees of March and September. This cocktail is held at the end of the day, after the Finance Committee meeting. This direct and regular communication helps establish an ongoing contact between the Staff Association and CERN Member States and, more recently, the Associate Member States. Ambassadors of the CERN Staff Association, who are Members of the Personnel, have the opportunity to meet their national delegation in an informal and friendly atmosphere. These exchanges, facilitated by the use of the national language, allow the personnel via the Staff Association to express its ideas and positions on current affairs and fundamental issues, and also to hear about those of the delegations in return.

  15. Lewy Body Dementia Association

    Science.gov (United States)

    ... Read Story A New Mission In Life Don Kent is a licensed attorney with a brilliant career. ... Reserved Lewy Body Dementia Association, Inc. 912 Killian Hill Road S.W., Lilburn, GA 30047 © 2016 Lewy Body ...

  16. Kennedy's Disease Association

    Science.gov (United States)

    Kennedy's Disease Association A Public Benefit, Non-Profit Organization Register GTranslate GTranslate Javascript is required to use ... educate, fund research, and find a cure for Kennedy's Disease Main Menu Home About Kennedy's Disease Kennedy's ...

  17. Healthcare Associated Infections - State

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Healthcare-Associated Infections (HAI) measures - state data. These measures are developed by Centers for Disease Control and Prevention (CDC) and collected...

  18. Healthcare Associated Infections - National

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Healthcare-Associated Infections (HAI) measures - national data. These measures are developed by Centers for Disease Control and Prevention (CDC) and collected...

  19. American Medical Association

    Science.gov (United States)

    ... AMA Wire For healthy individual market, keep tax rules that spur coverage Senate tax plan would scrap ... Foundation AMA Insurance Copyright 1995 - 2017 American Medical Association. All rights reserved. Terms of Use Privacy Policy ...

  20. National Fire Protection Association

    Science.gov (United States)

    ... Harvey became 'a landmark in the evolution of drone usage.' Learn more in NFPA Journal Storm stats ... YouTube GooglePlus Blogger Pinterest RSSFeeds Instagram Terms of Use Privacy Policy © National Fire Protection Association (NFPA) 2017

  1. American Pediatric Surgical Association

    Science.gov (United States)

    American Pediatric Surgical Association Search for: Login Resources + For Members For Professionals For Training Program Directors For Media For ... Surgical Outcomes Surveys & Results Publications Continuing Education + ExPERT Pediatric Surgery NaT Annual Meeting CME MOC Requirements Residents / ...

  2. Algae associated with mangroves

    Digital Repository Service at National Institute of Oceanography (India)

    Dhargalkar, V.K.

    are uprooted and enter the mangrove area. The epiphytic algal flora on mangrove trunks, pneumatophores, stilt roots, upper branches and canopies are comparatively poor. With regard to biotic factors there are a number of animals grazing on mangrove associated...

  3. American Public Health Association

    Science.gov (United States)

    ... faculty at @PBRCNews! Thanks to co-… Most food advertising to kids remains unhealthy, says @uconnruddcenter: https://t.co/wlWhLnwuEA Follow us on Twitter PH Jobs Coalition Development Associate | Community Anti-Drug ...

  4. Healthcare Associated Infections - Hospital

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Healthcare-Associated Infection (HAI) measures - provider data. These measures are developed by Centers for Disease Control and Prevention (CDC) and...

  5. Healthcare Associated Infections - State

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Healthcare-Associated Infections (HAI) measures - state data. These measures are developed by Centers for Disease Control and Prevention (CDC) and collected...

  6. [TATTOO-ASSOCIATED UVEITIS].

    Science.gov (United States)

    Klímová, A; Heissigerová, J; Říhová, E; Holan, P; Brichová, M; Svozílková, P

    2017-01-01

    The clinical case of tattoo-associated uveitis was first described by Lubeck and Epstein in 1952. Uveitis is accompanied by induration and hyperemia of tattoo skin, which can precede, follow or manifest simultaneously with uveitis. The diagnosis is determined on clinical grounds after exclusion of other causes. Uveitis is usually bilateral, chronic and vision impairment is variable. Tattoo-associated uveitis should be remembered in differential diagnosis due to the growing interest in tattoo.Key words: uveitis, tattoo, masquerade syndrome.

  7. Immunological memory is associative

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.J.; Forrest, S. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Computer Science; Perelson, A.S. [Los Alamos National Lab., NM (United States)

    1996-12-31

    The purpose of this paper is to show that immunological memory is an associative and robust memory that belongs to the class of sparse distributed memories. This class of memories derives its associative and robust nature by sparsely sampling the input space and distributing the data among many independent agents. Other members of this class include a model of the cerebellar cortex and Sparse Distributed Memory (SDM). First we present a simplified account of the immune response and immunological memory. Next we present SDM, and then we show the correlations between immunological memory and SDM. Finally, we show how associative recall in the immune response can be both beneficial and detrimental to the fitness of an individual.

  8. Associations with Minspeak icons.

    Science.gov (United States)

    van der Merwe, Elmarie; Alant, Erna

    2004-01-01

    Although the Minspeak approach is used on communication devices worldwide, little research has been conducted on its applicability within specific cultural contexts. The impact that users' familiarity of symbols and associations can have on learnability necessitates more systematic research. This study was an investigation into the associations which young South African adults from a tertiary education institution make with selected Minspeak icons, used in Unity software. Associations with the 12 core icons of the UniChat program were elicited from 480 able-bodied tertiary education students, using a cueing questionnaire. Each participant completed one questionnaire on one icon, so that 40 response questionnaires were obtained per icon. The responses from the questionnaires were pruned and computerised. Two analyses were done from these data: Firstly, the percentage of common associations per icon was calculated, and secondly, the elicited associations were compared to the current Unity vocabulary on a word and conceptual level. The results indicate that some of the icons and their encoded vocabulary items might be used successfully in the South African context, while others need to be adapted to be locally relevant. The results emphasize that iconic encoding systems based on commercially available graphic representational systems cannot merely be imported to South Africa due to the multicultural and multilingual nature of the context. As a result of this activity (1) the participant will be able to understand different types of associational responses based on icons used in Minspeak; (2) the participant will be able to understand the cultural relevance of some aspects of the Unity application programme; and (3) the participant will be able to identify different strategies that can be used to describe the cultural relevance o of the Unity application programme.

  9. Acromegaly associated with gangliocytoma.

    LENUS (Irish Health Repository)

    Crowley, R K

    2009-09-30

    BACKGROUND: Acromegaly secondary to growth hormone-releasing hormone (GHRH) excess is rare. AIMS\\/CASE DESCRIPTION: We report two patients with acromegaly who were diagnosed with sellar gangliocytomas that were immunopositive for GHRH. Tumour tissue persisted after debulking surgery and in the second case this was associated with persistent growth hormone hypersecretion, successfully suppressed by a somatostatin analogue. CONCLUSIONS: The development of functional pituitary adenomas in association with sellar gangliocytomas is poorly understood. We present a brief discussion of the possible aetiology of these unusual pituitary tumours.

  10. Land associations in Slovakia

    Directory of Open Access Journals (Sweden)

    Anna Bandlerová

    2017-10-01

    Full Text Available The land fragmentation is one of the serious problems in Slovakia which is given by the historical development of the land law. In the past, landowners tried to solve this problem by creation of various forms of land associations oriented to the common cultivation of agricultural land and forest land. Nowadays, the Slovak lawmaker decided to regulate the institute of land associations by the law. Land associations in Slovakia are legal entities conducting agricultural business on agricultural land, forest land or in water areas; moreover, they can provide also other business activities according to particular legal regulations. Land associations conduct business on real estate property or, more commonly, properties, which are usually owned by many co-owners, because the individual cultivation of small part of land plots would not be effective. However, the law is a subject of legal amendments more often than necessary in order to ensure the legal certainty. This paper introduces this recondite legal entity, its activities, its internal government and the ownership rights of its members. A pre-emption right that has a special legal regulation different from the general legal regulations of the pre-emption rights in the Civil Code is one of the special issues.

  11. HIV-associated vasculopathy

    African Journals Online (AJOL)

    Human immunodeficiency virus (HIV) disease was first described in 1981 in the USA in young homosexual men presenting with opportunistic infections associated with severe immune deficiency.1. The virus itself was identified 2 years later2 and the link between. HIV and acquired immune deficiency syndrome (AIDS) was.

  12. Tourniquet associated chemical burn

    Directory of Open Access Journals (Sweden)

    Jae-Hyuk Yang

    2012-01-01

    Full Text Available Chemical burn under pneumatic tourniquet is an iatrogenic preventable injury and is rarely reported in the literature. The two important mechanisms are maceration (friction and wetness underneath the tourniquent. In this report, our experience with two illustrative patients who presented with iatrogenic tourniquet associated burn is described.

  13. Canadian Nuclear Association

    International Nuclear Information System (INIS)

    Reid, John

    1992-01-01

    It is the view of the Canadian Nuclear Association that continuing creation of economic wealth is vital to sustainable development. A plentiful supply of cheap energy is essential. Nuclear energy provides the cleanest source of bulk energy generation essential to any path of sustainable development

  14. Guilt by association

    DEFF Research Database (Denmark)

    Perez-Moreno, Mirna; Fuchs, Elaine

    2012-01-01

    Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif...

  15. Hypertrophic Cardiomyopathy Association

    Science.gov (United States)

    ... be donated to Hypertrophic Cardiomyopathy Association. iGive.com - Online Shopping Joing iGive.com to earn money for the ... it works, check out the iGive website . AmazonSmile - Online Shopping Amazon donates 0.5% of the purchase price ...

  16. National Military Family Association

    Science.gov (United States)

    ... Take Action Volunteer Mark Your Calendar Donate Twitter Facebook Instagram Donate Appreciating Military Families: Meet the Wilsons This ... MilitaryFamily.org © 2017 - National Military Family Association Twitter Facebook Pinterest Instagram Charity Navigator Four Star Charity GuideStar Exchange Better ...

  17. Refugee by association

    Directory of Open Access Journals (Sweden)

    Blanche Tax

    2014-09-01

    Full Text Available Many Syrians, even when they have not been individually singled out, meet the refugee criteria on the grounds of being at risk of persecution because of a perceived association, in the broadest sense, with one of the parties to the conflict.

  18. Lenalidomide-Associated ITP

    Directory of Open Access Journals (Sweden)

    Christina I. Herold

    2011-01-01

    Full Text Available Lenalidomide is a potent immunomodulatory agent being used increasingly for treatment of hematologic malignancies including multiple myeloma and myelodysplasia. The common toxicities of lenalidomide, including dose-limiting myelosuppression, are well described. However, the immunomodulatory properties of lenalidomide may give rise to unexpected autoimmune complications. Herein, we describe a case of immune thrombocytopenic purpura (ITP associated with use of lenalidomide.

  19. Captopril-associated agranulocytosis

    African Journals Online (AJOL)

    1991-04-06

    Apr 6, 1991 ... times a day. Two patients recovered after withdrawal of the drug but the third died of septicaemia. Captopril-associated agranulocytosis is reviewed. S Air Med J 1991; 79: 399-400. Case reports. Case 1. A 56-year-old woman with longstanding hypertension suf- fered a myocardial infarction in May 1989.

  20. Refugee by association

    OpenAIRE

    Blanche Tax

    2014-01-01

    Many Syrians, even when they have not been individually singled out, meet the refugee criteria on the grounds of being at risk of persecution because of a perceived association, in the broadest sense, with one of the parties to the conflict.

  1. Whiplash-Associated Disorders

    DEFF Research Database (Denmark)

    Ferrara, S. D.; Ananian, V.; Baccino, E.

    2016-01-01

    The manuscript presents the International Guidelines developed by the Working Group on Personal Injury and Damage under the patronage of the International Academy of Legal Medicine (IALM) regarding the Methods of Ascertainment of any suspected Whiplash-Associated Disorders (WAD). The document...

  2. Osteosarcoma associated with hyperparathyroidism

    NARCIS (Netherlands)

    Jutte, PC; Rosso, R; de Paolis, M; Errani, C; Pasini, E; Campanacci, L; Bacci, G; Bertoni, F; Mercuri, M

    The fourth case in the literature is presented of a patient with the rare association of hyperparathyroidism and osteosarcoma. A 56-year-old woman presented with hyperparathyroidism and a lesion in the tibia. Initial diagnosis was brown tumor. Histology, however, revealed osteosarcoma, and the

  3. Civic Engagement and Associationalism

    DEFF Research Database (Denmark)

    Alexander, Damon Timothy; Barraket, Jo; Lewis, Jenny

    2012-01-01

    use a large survey to explore these questions empirically by focusing on the membership patterns and civic engagement practices of 4,001 citizens drawn from eight suburbs across Greater Melbourne, Australia. Our findings indicate that, while associational intensity is positively related to civic...

  4. Ontology in association rules.

    Science.gov (United States)

    Ferraz, Inhaúma Neves; Garcia, Ana Cristina Bicharra

    2013-01-01

    Data mining has emerged to address the problem of transforming data into useful knowledge. Although most data mining techniques, such as the use of association rules, may substantially reduce the search effort over large data sets, often, the consequential outcomes surpass the amount of information humanly manageable. On the other hand, important association rules may be overlooked owing to the setting of the support threshold, which is a very subjective metric, but rooted in most data mining techniques. This paper presents a study on the effects, in terms of precision and recall, of using a data preparation technique, called SemPrune, which is built on domain ontology. SemPrune is intended for pre- and post-processing phases of data mining. Identifying generalization/specialization relations, as well as composition/decomposition relations, is the key to successfully applying SemPrune.

  5. HIV-Associated Psoriasis.

    Science.gov (United States)

    Queirós, N; Torres, T

    2018-01-17

    Human immunodeficiency virus (HIV) prevalence is increasing worldwide as people on antiretroviral therapy are living longer. These patients are often susceptible to debilitating inflammatory disorders that are frequently refractory to standard treatment. Psoriasis is a systemic inflammatory disorder, associated with both physical and psychological burden, and can be the presenting feature of HIV infection. In this population, psoriasis tends to be more severe, to have atypical presentations and higher failure rates with the usual prescribed treatments. Management of moderate and severe HIV-associated psoriasis is challenging. Systemic conventional and biologic agents may be considered, but patients should be carefully followed up for potential adverse events, like opportunist infections, and regular monitoring of CD4 counts and HIV viral loads. Copyright © 2017 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. [Ventilator associated pneumonia].

    Science.gov (United States)

    Bellani, S; Nesci, M; Celotto, S; Lampati, L; Lucchini, A

    2003-04-01

    Ventilator associated pneumonia (VAP) is a nosocomial lower respiratory tract infection that ensues in critically ill patients undergoing mechanical ventilation. The reported incidence of VAP varies between 9% and 68% with a mortality ranging between 33% and 71%. Two key factors are implicated in the pathogenesis of VAP: bacterial colonization of the upper digestive-respiratory tract and aspiration of oral secretions into the trachea. Preventive measurements are advocated to reduce the incidence of VAP, such as selective decontamination of the digestive tract (SDD), supraglottic aspiration and positioning. Prompt recognition and treatment of established VAP has also been demostrated to affect outcome. Therefore, the knowledge of risk factors associated with the development of VAP and the implementation of strategies to prevent, diagnose and treat VAP are mainstems in the nursing of mechanically ventilated patients.

  7. Fellows, Associates & Students Programmes

    CERN Document Server

    2005-01-01

    The present document reviews the CERN Fellows, Associates and Students Programmes emphasizing the developments since 2000, when the previous review was presented to the Scientific Policy Committee, Finance Committee and Council (CERN/2325), and makes proposals for the coming five years. In summary, it is proposed to â?¢ Simplify the payment scheme for the Paid Scientific Associates Programme, which will no longer depend on candidateâ??s home support and age; â?¢ Broaden the scope of the Fellowship Programme, in order to facilitate the recruitment of young graduates in computing and engineering. Age-related eligibility conditions and payment levels will be replaced with experience-based criteria; â?¢ Modify subsistence rates for the Doctoral and Technical Student Programme in order to harmonize CERNâ??s payment levels with those offered by other research establishments. This document is presented for discussion and recommendation by the Scientific Policy Committee and approval by the Council. Additiona...

  8. Freedom and Association

    OpenAIRE

    Hill, Christopher Leslie Gowens

    2017-01-01

    The project Freedom and Association is a flexible, fluid, and personal investment in practice that loosens forms of language and opens up structures of value that cohere onto words and objects. The non-fixed, process-based nature of the practical component of the research is extended in an understanding of post anarchism - as an ongoing, lived experience of the everyday and of friendship. I define anarchism as the rejection of dominant power structures and as pertaini...

  9. Carcinoma-associated antigens

    International Nuclear Information System (INIS)

    Bartorelli, A.; Accinni, R.

    1981-01-01

    This invention relates to novel antigens associated with breast carcinoma, anti-sera specific to said antigens, 125 I-labeled forms of said antigens and methods of detecting said antigens in serum or plasma. The invention also relates to a diagnostic kit containing standardised antigens or antisera or marked forms thereof for the detection of said antigens in human blood, serum or plasma. (author)

  10. Quantum Associative Memory

    OpenAIRE

    Ventura, Dan; Martinez, Tony

    1998-01-01

    This paper combines quantum computation with classical neural network theory to produce a quantum computational learning algorithm. Quantum computation uses microscopic quantum level effects to perform computational tasks and has produced results that in some cases are exponentially faster than their classical counterparts. The unique characteristics of quantum theory may also be used to create a quantum associative memory with a capacity exponential in the number of neurons. This paper combi...

  11. Thyroid-associated Ophthalmopathy

    Directory of Open Access Journals (Sweden)

    Esra Şahlı

    2017-03-01

    Full Text Available Thyroid-associated ophthalmopathy is the most frequent extrathyroidal involvement of Graves’ disease but it sometimes occurs in euthyroid or hypothyroid patients. Thyroid-associated ophthalmopathy is an autoimmune disorder, but its pathogenesis is not completely understood. Autoimmunity against putative antigens shared by the thyroid and the orbit plays a role in the pathogenesis of disease. There is an increased volume of extraocular muscles, orbital connective and adipose tissues. Clinical findings of thyroid-associated ophthalmopathy are soft tissue involvement, eyelid retraction, proptosis, compressive optic neuropathy, and restrictive myopathy. To assess the activity of the ophthalmopathy and response to treatment, clinical activity score, which includes manifestations reflecting inflammatory changes, can be used. Supportive approaches can control symptoms and signs in mild cases. In severe active disease, systemic steroid and/or orbital radiotherapy are the main treatments. In inactive disease with proptosis, orbital decompression can be preferred. Miscellaneous treatments such as immunosuppressive drugs, somatostatin analogs, plasmapheresis, intravenous immunoglobulins and anticytokine therapies have been used in patients who are resistant to conventional treatments. Rehabilitative surgeries are often needed after treatment.

  12. Sudoku associative memory.

    Science.gov (United States)

    Wu, Jiann-Ming; Hsu, Pei-Hsun; Liou, Cheng-Yuan

    2014-09-01

    This work presents bipolar neural systems for check-rule embedded pattern restoration, fault-tolerant information encoding and Sudoku memory construction and association. The primitive bipolar neural unit is generalized to have internal fields and activations, which are respectively characterized by exponential growth and logistic differential dynamics, in response to inhibitory and excitatory stimuli. Coupling extended bipolar units induces multi-state artificial Potts neurons which are interconnected with inhibitory synapses for Latin square encoding, K-alphabet Latin square encoding and Sudoku encoding. The proposed neural dynamics can generally restore Sudoku patterns from partial sparse clues. Neural relaxation is based on mean field annealing that well guarantees reliable convergence to ground states. Sudoku associative memory combines inhibitory interconnections of Sudoku encoding with Hebb's excitatory synapses of encoding conjunctive relations among active units over memorized patterns. Sudoku associative memory is empirically shown reliable and effective for restoring memorized patterns subject to typical sparse clues, fewer partial clues, dense clues and perturbed or damaged clues. On the basis, compound Sudoku patterns are further extended to emulate complex topological information encoding. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Scoliosis Associated With Syringomyelia

    Directory of Open Access Journals (Sweden)

    Gh Fathi

    2007-01-01

    Full Text Available Introduction: The differential diagnosis of idiopathic and syringomyelia associated scoliosis is important because corrective surgery for scoliosis associated with syringomyelia prior to management of syringomyelia can be dangerous. There are important imaging indicators for diagnosis of syringomyelia associated with scoliosis. A few of these indicators have been assessed in our study. Methods: A retrospective descriptive study including 38 patients with both scoliosis and syringomyelia was performed at the Shafa Yahyaeian center. Standard scoliosis series radiographs and MRI of all patients were studied. The type of scoliosis, location and magnitude of deformity, kyphosis or lordosis in the sagittal plane, location and size of syrinx were assessed. Results: Thoracic kyphosis was present in 94.7% of patients. 37% of patients had scoliosis with convexity to left. Arnold –chiari malformation was present in 36% and cord tethering in 21% of patients. The locations of syrinx were as follows: 47.4%cervical, 44.6 thoracic, 2.7% lumbar and 5.3% were holocord. Conclusion: Kyphosis, abscence of lordosis in sagittal plane, progressive scoliosis and scoliosis with convexity to left are atypical findings and could be indicators of the presence of syringomyelia. If these indicators are present, a diagnosis of idiopathic scoliosis should be made with caution.

  14. Osteosarcoma associated with hyperparathyroidism

    International Nuclear Information System (INIS)

    Jutte, Paul C.; Rosso, Renato; Paolis, Massimiliano de; Errani, Costatino; Pasini, Elisabetta; Campanacci, Laura; Bacci, Gaetano; Bertoni, Franco; Mercuri, Mario

    2004-01-01

    The fourth case in the literature is presented of a patient with the rare association of hyperparathyroidism and osteosarcoma. A 56-year-old woman presented with hyperparathyroidism and a lesion in the tibia. Initial diagnosis was brown tumor. Histology, however, revealed osteosarcoma, and the patient was treated accordingly. The experimental induction of osteosarcoma by parathormone in rodent studies makes this finding alarming, considering the increasing use of parathormone in the treatment of osteoporosis. The mechanism by which osteosarcoma is induced in humans cannot be explained based on current knowledge of mechanisms of action of parathyroid hormone. (orig.)

  15. Dermatosis associated with menopause

    Directory of Open Access Journals (Sweden)

    Pragya A Nair

    2014-01-01

    Full Text Available Menopause is defined as permanent irreversible cessation of menses brought by decline in ovarian follicular activity. Hormonal alteration results in various physical, psychological, and sexual changes in menopausal women. Associated dermatological problems can be classified as physiological changes, age-related changes, changes due to estrogen deficiency and due to hormone replacement therapy. Dermatosis seen due to estrogen deficiency includes Atrophic Vulvovaginitis, Vulvar Lichen Sclerosus, Dyaesthetic Vulvodynia, Hirsutism, Alopecia, Menopausal Flushing, Keratoderma Climactericum, Vulvovaginal Candidiasis. Dermatologists and gynecologists need to be familiar with the problems of menopausal women, as with increase in life expectancy, women passing through this phase is rising.

  16. Pancytopenia associated with clonazepam.

    Science.gov (United States)

    Bautista-Quach, Marnelli A; Liao, Yu-Min; Hsueh, Chung-Tsen

    2010-07-14

    We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subsequently, she was hospitalized for neutropenic fever with thrombocytopenia and worsening anemia. Bone marrow examination demonstrated a markedly hypocellular marrow (10-20% total cellularity). Clonazepam was discontinued, with gradual improvement of thrombocytopenia, and neutropenia in 1-2 weeks. To our knowledge, this is the first reported case of pancytopenia associated with clonazepam. We recommend patients taking clonazepam to be monitored with regular complete blood count to check for clinically significant pancytopenia or thrombocytopenia.

  17. Osteosarcoma associated with hyperparathyroidism

    Energy Technology Data Exchange (ETDEWEB)

    Jutte, Paul C. [Istituti Orthopedici Rizzoli, Via Pupilli 1, 40136, Bologna (Italy); University Medical Center Groningen, PO Box 30.001, 9700 RB, Groningen (Netherlands); Rosso, Renato [Anatomia Patologica Universita di Pavia, via Forlanini 16, 27100, Pavia (Italy); Paolis, Massimiliano de; Errani, Costatino; Pasini, Elisabetta; Campanacci, Laura; Bacci, Gaetano; Bertoni, Franco; Mercuri, Mario [Istituti Orthopedici Rizzoli, Via Pupilli 1, 40136, Bologna (Italy)

    2004-08-01

    The fourth case in the literature is presented of a patient with the rare association of hyperparathyroidism and osteosarcoma. A 56-year-old woman presented with hyperparathyroidism and a lesion in the tibia. Initial diagnosis was brown tumor. Histology, however, revealed osteosarcoma, and the patient was treated accordingly. The experimental induction of osteosarcoma by parathormone in rodent studies makes this finding alarming, considering the increasing use of parathormone in the treatment of osteoporosis. The mechanism by which osteosarcoma is induced in humans cannot be explained based on current knowledge of mechanisms of action of parathyroid hormone. (orig.)

  18. Vaccine Associated Myocarditis

    Directory of Open Access Journals (Sweden)

    Johnson Francis

    2017-04-01

    Full Text Available Most of the cases of vaccine associated myocarditis have been following small pox vaccination. Reports have also been there after streptococcal pneumonia vaccine and influenza vaccine. In some cases, autoimmune/inflammatory syndrome induced by adjuvants (ASIA used in the vaccine have been implicated. Exclusion of other causes is very important in the diagnostic process, especially that of acute coronary syndrome. Management is similar to that of other etiologies of myocarditis. These rare instances of myocarditis should not preclude one from taking necessary immunization for vaccine preventable diseases.

  19. Associated morbidity of chalazia.

    Science.gov (United States)

    Nemet, Arie Y; Vinker, Shlomo; Kaiserman, Igor

    2011-12-01

    Chalazion may be associated with some local and systemic conditions. We studied the prevalence of various conditions among patients with chalazion. A retrospective observational case-control study of all the members who were diagnosed with chalazion in the Central District of Clalit Health Services in Israel (years 2000-2008; n = 9119) and 9119 age- and gender-matched controls randomly selected from the district members. We calculated the prevalence of various ocular, systemic, and demographic conditions as risk factors for chalazion. Demographically, a significant (P chalazion was found in the population of lower socioeconomic class, in the population living in urban areas, in young females (10-29 years), in older men (older than 60 years), and in non-Ashkenazi Jews. The following risk factors of chalazion were statistically significant: blepharitis [odds ratio (OR), 6.2], rosacea (OR, 2.9), gastritis (OR, 1.4), anxiety (OR, 1.5), irritable bowel syndrome (OR, 1.7), and smoking (OR, 1.2). Diabetes (OR, 0.8) and hypothyroidism (OR, 0.8) were significantly less prevalent among chalazion patients. Some systemic conditions are significantly more prevalent and some are significantly less prevalent among patients with chalazion. Better understanding of the pathophysiological association between those diseases and chalazion may help in its treatment and prevention.

  20. Endometriosis Associated with Hemothorax

    Directory of Open Access Journals (Sweden)

    Hung-Tsung Lee

    2006-01-01

    Full Text Available Bloody pleural effusion is rarely associated with endometriosis. To effectively treat this condition, it is important to differentiate the malady from other common diseases such as malignancy or tuberculosis. We describe the case of a 40-year-old multiparous female featuring right-sided hemothorax presenting with right shoulder pain and progressive shortness of breath for the preceding 2 months. Thoracoscopy disclosed grossly negative findings apart from multiple small pores in the right hemi-diaphragm with blood clots within them. Examination of the thoracoscopic biopsy specimens showed chronic pleuritis without evidence of malignancy or tuberculosis. Pelvic endometriosis was considered a possible diagnosis according to the results of abdominal computed tomography (CT scan, transvaginal sonography, and the results of dilatation and curettage. Periodic episodes of symptoms concurrent with menstruation led to the suspicion of a relationship between these conditions in our patient. Despite the patient undergoing an abdominal total hysterectomy and adhesiolysis without salpingo-oophorectomy, recurrent right-sided bloody pleural effusion developed 1.5 months subsequent to surgery. As a consequence, danazol (400 mg/day was maintained because of the endometriosis associated with pleural effusion. One year of regular follow-up later, there was no evidence of recurrent pleural effusion. We considered that the bloody pleural fluid arose via seepage from the pelvic endometriosis through the pores of the right hemi-diaphragm during menstruation.

  1. Ventilator-associated pneumonia.

    Science.gov (United States)

    Shaw, Michael Jan

    2005-05-01

    This review summarises some of the notable papers on ventilator-associated pneumonia (VAP) from January 2003 to October 2004. Ventilator-associated pneumonia remains an important drain on hospital resources. All population groups are affected, but patients with VAP are more likely to be older, sicker, and male, with invasive medical devices in situ. Early VAP diagnosis is desirable to reduce VAP mortality and to retard emergence of multidrug-resistant microbes. This may be possible using preliminary culture results or intracellular organism in polymorphonuclear cells. In most intensive care units, Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii are the commonest organisms isolated in VAP. However, causative organisms vary between and within hospitals. Consequently, individual intensive care units should develop empirical antibiotic policies to target the pathogenic bacteria prevalent in their patient populations. Preventative strategies aimed at reducing aerodigestive tract colonisation by pathogenic organisms, and also their subsequent aspiration, are becoming increasingly important. Educating medical staff about these simple measures is therefore pertinent. To reduce the occurrence of multidrug-resistant organisms, limiting the duration of antibiotic treatment to 8 days and antimicrobial rotation should be contemplated. Empirical therapy with antipseudomonal penicillins plus beta-lactamase inhibitors should be considered. If methicillin-resistant Staphylococcus aureus VAP is a possibility, linezolid may be better than vancomycin. Prevention remains the key to reducing VAP prevalence.

  2. Hom-associative Ore extensions

    Science.gov (United States)

    Bäck, P.; Richter, J.; Silvestrov, S.

    2018-02-01

    We introduce hom-associative Ore extensions as non-associative, non-unital Ore extensions with a hom-associative multiplication, as well as give some necessary and sufficient conditions when such exist. Within this framework, we also construct a family of hom-associative Weyl algebras as generalizations of the classical analogue, and prove that they are simple.

  3. Retinoblastoma associated orbital cellulitis

    Science.gov (United States)

    Mullaney, P.; Karcioglu, Z.; Huaman, A.; Al-Mesfer, S.

    1998-01-01

    AIM—Preseptal and orbital cellulitis are rare presenting features of intraocular retinoblastoma. The objectives of this study were to determine the frequency of retinoblastoma associated cellulitis, as well as to review its clinical and histopathological features.
METHODS—The medical records of 292 retinoblastoma patients in the King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia were reviewed. Those indicating a history of, or presenting with, cellulitis were retrieved and their clinical, radiological, and histopathological variables were assessed. Patients with definite extraocular tumour extension on clinical or radiological examination were excluded.
RESULTS—14 patients were found to have retinoblastoma associated cellulitis (4.8%); nine had bilateral and five had unilateral retinoblastoma. Conjunctival and blood cultures were performed in 10 cases and were negative. 10 children were treated with intravenous steroids, often in conjunction with antibiotics, resulting in a prompt decrease in inflammation. Three other children were treated with antibiotics alone and one received no treatment. Computed tomographic scanning depicted large intraocular tumours occupying between 80% and 100% of the globe in each case. In eight patients, periocular inflammation was radiologically interpreted as possible extraocular extension. In one patient serial computed tomographic scanning showed a reduction in intraocular calcification over time which occurred in the presence of cellulitis. 12 patients underwent enucleation and histopathological examination revealed large necrotic, poorly differentiated tumours associated with uveal involvement and early optic nerve invasion. Focal perilimbal destruction was seen in one patient, and in another peripapillary extrascleral extension was present. 12 patients are alive with a mean follow up of 56.4 months.
CONCLUSIONS—Radiological evaluation of scleral integrity may be hindered by periocular inflammatory

  4. Pancytopenia associated with clonazepam

    Directory of Open Access Journals (Sweden)

    Hsueh Chung-Tsen

    2010-07-01

    Full Text Available Abstract We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subsequently, she was hospitalized for neutropenic fever with thrombocytopenia and worsening anemia. Bone marrow examination demonstrated a markedly hypocellular marrow (10-20% total cellularity. Clonazepam was discontinued, with gradual improvement of thrombocytopenia, and neutropenia in 1-2 weeks. To our knowledge, this is the first reported case of pancytopenia associated with clonazepam. We recommend patients taking clonazepam to be monitored with regular complete blood count to check for clinically significant pancytopenia or thrombocytopenia.

  5. MUTYH Associated Polyposis (MAP)

    DEFF Research Database (Denmark)

    Poulsen, Marie Louise Mølgaard; Bisgaard, M L

    2008-01-01

    MUTYH Associated Polyposis (MAP), a Polyposis predisposition caused by biallelic mutations in the Base Excision Repair (BER) gene MUTYH, confers a marked risk of colorectal cancer (CRC). The MAP phenotype is difficult to distinguish from other hereditary CRC syndromes. Especially from Familial...... Adenomatous Polyposis (FAP) and to a lesser extend Lynch Syndrome, which are caused by germline mutations in the APC and Mismatch Repair (MMR) genes, respectively.Here we review research findings regarding MUTYH interactions, genotypic and phenotypic characteristics of MAP, as well as surveillance......, cooperation between the BER and the MMR systems exists, as MUTYH interacts with MMR gene-products. Possibly, monoallelic defects in both pathways are of significance to CRC development.Specific MUTYH variants are found to be characteristic in distinct ethnic populations, which could facilitate future genetic...

  6. Tattoo associated retinochoroiditis.

    Science.gov (United States)

    Orellana Rios, J; Verdaguer Díaz, J I; Agee, J; Theodore Smith, R

    2018-04-01

    A young woman was referred to our offices with impairment of visual acuity after she received a third tattoo on her arm. Systemic medical and laboratory work-up were performed in order to exclude an infectious agent or inflammatory disease. A yellowish juxtafoveal lesion in left eye along with a plaque-like outer retinal disruption and focal pigmentary defects was assessed using multi-modal diagnostic imaging. Ophthalmologists treating uveitis should consider this uncommon association and question patients regarding tattoos and tattoo inflammation given the rise of subjects undergoing artistic tattooing. Copyright © 2017 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

  7. Urolithiasis associated with topiramate

    Directory of Open Access Journals (Sweden)

    Scott Eggener

    2004-02-01

    Full Text Available OBJECTIVE: Topiramate is a sulfamate-substituted monosaccharide anticonvulsant used as adjunctive therapy for intractable refractory seizures. It is report a case of topiramate-induced urolithiasis. CASE REPORT: A 35-year-old man presented with acute, right-sided, colicky flank pain. He denied hematuria or dysuria. He was in use of phenytoin, risperidone, phenobarbital, and topiramate. The total daily dose of topiramate was 375 mg. A CT scan showed a 7 x 1 mm curvilinear density at the right ureterovesical junction with proximal hydrouretronephrosis. He was managed with rigid ureteroscopic stone extraction and the calculus metabolic analysis revealed the stone was composed of carbonate apatite (70%, calcium oxalate dihydrate (20%, and calcium oxalate monohydrate (10%. COMMENTS: The present case typifies many features of topiramate-induced urolithiasis. Those who care for patients with urinary stone disease should be aware of this association.

  8. Sleepwalking associated with hyperthyroidism.

    Science.gov (United States)

    Ajlouni, Kamel M; Ahmad, Azmi T; El-Zaheri, Mohamed M; Al-Zahiri, Mohammad M; Ammari, Fawwaz L; Jarrah, Nadim S; AbuJbara, Mousa A; Ajlouni, Heitham K; Daradkeh, Tewfik K

    2005-01-01

    To report several cases of hyperthyroidism in patients presenting with the unusual symptom of sleepwalking and to discuss the possible pathophysiologic basis for this novel association. After encountering and reporting the first case of new-onset somnambulism in a patient presenting with thyrotoxicosis at our institution, we routinely inquired about the sleep history of patients with thyrotoxicosis, questioning both the patients and family members when applicable. Those patients who actually had sleepwalking episodes coinciding with the onset of thyrotoxicosis underwent close follow-up, and the relationship between the sleepwalking and the results of thyroid function tests was analyzed. In addition, we reviewed the literature on psychiatric disorders and sleep problems, and the pathophysiologic rationale for a cause-and-effect relationship is discussed. We collected 8 cases of patients with new-onset sleepwalking episodes that coincided with the start of thyrotoxicosis. The disappearance of the sleepwalking with successful achievement of euthyroidism supports a cause-and-effect relationship. This hypothesis is further supported by the absence of a family history, the adult onset, and the relapse of sleepwalking in 2 of the patients when their thyrotoxicosis became poorly controlled as a result of noncompliance with medications and its subsequent disappearance with reachievement of euthyroidism. Of note, such a presentation was seen only in patients with thyrotoxicosis caused by diffuse toxic goiter or Graves' disease and never in patients with other causes of thyrotoxicosis. New-onset sleepwalking could be caused by thyrotoxicosis or, more specifically, by thyrotoxicosis resulting from diffuse toxic goiter. The mechanism is hypothesized to be related to the combination of prolongation of non-rapid eye movement sleep and the associated fatigue. Specific inquiry about this unusual presentation of thyrotoxicosis is encouraged, and more studies are needed to confirm

  9. Vaccine-associated hypersensitivity.

    Science.gov (United States)

    McNeil, Michael M; DeStefano, Frank

    2018-02-01

    Vaccine-associated hypersensitivity reactions are not infrequent; however, serious acute-onset, presumably IgE-mediated or IgG and complement-mediated anaphylactic or serious delayed-onset T cell-mediated systemic reactions are considered extremely rare. Hypersensitivity can occur because of either the active vaccine component (antigen) or one of the other components. Postvaccination acute-onset hypersensitivity reactions include self-limited localized adverse events and, rarely, systemic reactions ranging from urticaria/angioedema to full-blown anaphylaxis with multisystem involvement. Risk of anaphylaxis after all vaccines is estimated to be 1.31 (95% CI, 0.90-1.84) per million vaccine doses, respectively. Serious hypersensitivity reactions after influenza vaccines are particularly important because of the large number of persons vaccinated annually. Influenza vaccines are unique in requiring annual changes in the vaccines' antigenic composition to match the predicted circulating influenza strains. Recently, novel influenza vaccine types were introduced in the United States (recombinant vaccines, some with higher antigen content and a new adjuvanted vaccine). Providers should be aware of changing recommendations on the basis of recent published evidence for persons with a history of egg allergy to receive annual influenza vaccination. Further research is needed to elucidate the pathophysiology and risk factors for reported vaccine-associated adverse events. Further research is also needed to determine whether repeated annual inactivated influenza vaccination, the number of vaccine antigens administered at the same time, and the current timing of routine infant vaccinations are optimal for overall population well-being. Published by Elsevier Inc.

  10. Pregnancy associated pancreatitis revisited.

    Science.gov (United States)

    Igbinosa, Osamuyimen; Poddar, Sameer; Pitchumoni, Capercomorin

    2013-04-01

    To evaluate the demographics, risk factors and outcomes of pregnancy associated pancreatitis (PAP). A retrospective chart review was done using ICD-9 Code 577.0 (acute pancreatitis) from January 2005 through December 2009. Women aged 18 to 45 years, who were pregnant and 6 months after delivery were considered for the study. For each case, two women of the same age (± 4 years) with no history of pancreatitis were matched as control. Demographics, etiology, diagnostic modality and intervention were obtained. During the 5 years of study, 29 cases of PAP occurred among 25,600 total hospital deliveries, yielding prevalence of 0.001%: Hispanics 48%, Caucasians 24%, African Americans 17.2%, and Asian/Pacific Islanders 13% (Ppregnancy body mass index (BMI) more than 30 kg/m(2) had PAP, versus 24% with BMI between 25 and 30 kg/m(2) and 10% with BMI less than 25 kg/m(2) (Ppregnancy. Gallstone disease is the most frequent etiology for PAP and tends to occur more often in Hispanics in New Jersey. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  11. Simulated Associating Polymer Networks

    Science.gov (United States)

    Billen, Joris

    Telechelic associating polymer networks consist of polymer chains terminated by endgroups that have a different chemical composition than the polymer backbone. When dissolved in a solution, the endgroups cluster together to form aggregates. At low temperature, a strongly connected reversible network is formed and the system behaves like a gel. Telechelic networks are of interest since they are representative for biopolymer networks (e.g. F-actin) and are widely used in medical applications (e.g. hydrogels for tissue engineering, wound dressings) and consumer products (e.g. contact lenses, paint thickeners). In this thesis such systems are studied by means of a molecular dynamics/Monte Carlo simulation. At first, the system in rest is studied by means of graph theory. The changes in network topology upon cooling to the gel state, are characterized. Hereto an extensive study of the eigenvalue spectrum of the gel network is performed. As a result, an in-depth investigation of the eigenvalue spectra for spatial ER, scale-free, and small-world networks is carried out. Next, the gel under the application of a constant shear is studied, with a focus on shear banding and the changes in topology under shear. Finally, the relation between the gel transition and percolation is discussed.

  12. Sepsis Associated Encephalopathy

    Directory of Open Access Journals (Sweden)

    Neera Chaudhry

    2014-01-01

    Full Text Available Sepsis associated encephalopathy (SAE is a common but poorly understood neurological complication of sepsis. It is characterized by diffuse brain dysfunction secondary to infection elsewhere in the body without overt CNS infection. The pathophysiology of SAE is complex and multifactorial including a number of intertwined mechanisms such as vascular damage, endothelial activation, breakdown of the blood brain barrier, altered brain signaling, brain inflammation, and apoptosis. Clinical presentation of SAE may range from mild symptoms such as malaise and concentration deficits to deep coma. The evaluation of cognitive dysfunction is made difficult by the absence of any specific investigations or biomarkers and the common use of sedation in critically ill patients. SAE thus remains diagnosis of exclusion which can only be made after ruling out other causes of altered mentation in a febrile, critically ill patient by appropriate investigations. In spite of high mortality rate, management of SAE is limited to treatment of the underlying infection and symptomatic treatment for delirium and seizures. It is important to be aware of this condition because SAE may present in early stages of sepsis, even before the diagnostic criteria for sepsis can be met. This review discusses the diagnostic approach to patients with SAE along with its epidemiology, pathophysiology, clinical presentation, and differential diagnosis.

  13. Mortality associated with phaeochromocytoma.

    Science.gov (United States)

    Prejbisz, A; Lenders, J W M; Eisenhofer, G; Januszewicz, A

    2013-02-01

    Two major categories of mortality are distinguished in patients with phaeochromocytoma. First, the effects of excessive circulating catecholamines may result in lethal complications if the disease is not diagnosed and/or treated timely. The second category of mortality is related to development of metastatic disease or other neoplasms. Improvements in disease recognition and diagnosis over the past few decades have reduced mortality from undiagnosed tumours. Nevertheless, many tumours remain unrecognised until they cause severe complications. Death resulting from unrecognised or untreated tumour is caused by cardiovascular complications. There are also numerous drugs and diagnostic or therapeutic manipulations that can cause fatal complications in patients with phaeochromocytoma. Previously it has been reported that operative mortality was as high as 50% in unprepared patients with phaeochromocytoma who were operated and in whom the diagnosis was unsuspected. Today mortality during surgery in medically prepared patients with the tumour is minimal. Phaeochromocytomas may be malignant at presentation or metastases may develop later, but both scenarios are associated with a potentially lethal outcome. Patients with phaeochromocytoma run an increased risk to develop other tumours, resulting in an increased mortality risk compared to the general population. Phaeochromocytoma during pregnancy represents a condition with potentially high maternal and foetal mortality. However, today phaeochromocytoma in pregnancy is recognised earlier and in conjunction with improved medical management, maternal mortality has decreased to less than 5%. © Georg Thieme Verlag KG Stuttgart · New York.

  14. Associated particle imaging (API)

    International Nuclear Information System (INIS)

    1998-05-01

    Associated Particle Imaging (API) is an active neutron probe technique that provides a 3-D image with elemental composition of the material under interrogation, and so occupies a unique niche in the interrogation of unknown objects. The highly penetrating nature of neutrons enables API to provide detailed information about targets of interest that are hidden from view. Due to the isotropic nature of the induced reactions, radiation detectors can be set on the same side of the object as the neutron source, so that the object can be interrogated from a single side. At the heat of the system is a small generator that produces a continuous, monoenergetic flux of neutrons. By measuring the trajectory of coincident alpha particles that are produced as part of the process, the trajectory of the neutron can be inferred. Interactions between a neutron and the material in its path often produce a gamma ray whose energy is characteristic of that material. When the gamma ray is detected, its energy is measured and combined with the trajectory information to produce a 3-D image of the composition of the object being interrogated. During the course of API development, a number of improvements have been made. A new, more rugged sealed Tube Neutron Generator (STNG) has been designed and fabricated that is less susceptible to radiation damage and better able to withstand the rigors of fielding than earlier designs. A specialized high-voltage power supply for the STNG has also been designed and built. A complete package of software has been written for the tasks of system calibration, diagnostics and data acquisition and analysis. A portable system has been built and field tested, proving that API can be taken out of the lab and into real-world situations, and that its performance in the field is equal to that in the lab

  15. The Growth-Inequality Association:

    DEFF Research Database (Denmark)

    Bjørnskov, Christian

    2008-01-01

    This note suggests that the association between income inequality and economic growth rates might arguably depend on the political ideology of incumbent governments. Estimates indicate that under leftwing governments, inequality is negatively associated with growth while the association is positive...... under rightwing governments. This may provide a qualification to recent studies of inequality....

  16. Submanifolds weakly associated with graphs

    Indian Academy of Sciences (India)

    theory by defining submanifolds weakly associated with graphs. We prove that, in a local sense, every submanifold satisfies such an association, and other general results. Finally, we study submanifolds associated with graphs either in low dimensions or belonging to some special families. Keywords. Almost Hermitian ...

  17. Submanifolds weakly associated with graphs

    Indian Academy of Sciences (India)

    We establish an interesting link between differential geometry and graph theory by defining submanifolds weakly associated with graphs. We prove that, in a local sense, every submanifold satisfies such an association, and other general results. Finally, we study submanifolds associated with graphs either in low ...

  18. Interfacial Protein-Protein Associations

    OpenAIRE

    Langdon, Blake B.; Kastantin, Mark; Walder, Robert; Schwartz, Daniel K.

    2013-01-01

    While traditional models of protein adsorption focus primarily on direct protein-surface interactions, recent findings suggest that protein-protein interactions may play a central role. Using high-throughput intermolecular resonance energy transfer (RET) tracking, we directly observed dynamic, protein-protein associations of bovine serum albumin on poly(ethylene glycol) modified surfaces. The associations were heterogeneous and reversible, and associating molecules resided on the surface for ...

  19. Mandibular Osteonecrosis Associated With Raloxifene.

    Science.gov (United States)

    Pontes, Hélder Antônio Rebelo; de Souza, Lucas Lacerda; Uchôa, Daniel Cavalléro Colares; Cerqueira, João Mateus Mendes

    2018-01-04

    Osteonecrosis is a disease with diverse pathophysiology, clinical presentation, and management. It may be associated with some medications used to treat systemic issues with bone metabolism. A few cases of jaw bone osteonecrosis have been associated with raloxifene. In this paper, the authors present a clinical report of a 64-year-old woman who presented with a necrosis foci in the right alveolar ridge of the mandible, associated with continued raloxifene use.

  20. Dengue-associated neuromuscular complications

    OpenAIRE

    Ravindra Kumar Garg; Hardeep Singh Malhotra; Amita Jain; Kiran Preet Malhotra

    2015-01-01

    Dengue is associated with many neurological dysfunctions. Up to 4% of dengue patients may develop neuromuscular complications. Muscle involvement can manifest with myalgias, myositis, rhabdomyolysis and hypokalemic paralysis. Diffuse myalgia is the most characteristic neurological symptom of dengue fever. Dengue-associated myositis can be of varying severity ranging from self-limiting muscle involvement to severe dengue myositis. Dengue-associated hypokalemic paralysis often has a rapidly evo...

  1. Grouping by association: using associative networks for document categorization

    NARCIS (Netherlands)

    Bloom, Niels

    2015-01-01

    In this thesis we describe a method of using associative networks for automatic doc- ument grouping. Associative networks are networks of ideas or concepts in which each concept is linked to concepts that are semantically similar to it. By activating concepts in the network based on the text of a

  2. Regulating the nursing associate profession.

    Science.gov (United States)

    Glasper, Alan

    2017-11-23

    Emeritus Professor Alan Glasper, University of Southampton, discusses the Government's consultation on changes to the Nursing and Midwifery Order 2001 and the legislation to regulate nursing associates.

  3. Cutaneous manifestations associated with melanoma.

    Science.gov (United States)

    Vyas, Ritva; Selph, Jacqueline; Gerstenblith, Meg R

    2016-06-01

    Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated with local or diffuse pigmentation changes, including depigmentation associated with the leukodermas and hyperpigmentation associated with diffuse melanosis cutis. The leukodermas occur frequently, illustrate the immunogenic nature of melanoma, and may impact prognosis. Paraneoplastic syndromes in association with melanoma are rare, though can occur. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Association between Oral Anticoagulation Knowledge ...

    African Journals Online (AJOL)

    Association between Oral Anticoagulation Knowledge, Anticoagulation Control, and Demographic Characteristics of Patients Attending an Anticoagulation Clinic in Saudi Arabia: A Cross-Sectional Prospective Evaluation.

  5. Risk factors associated with development of ventilator associated pneumonia.

    Science.gov (United States)

    Noor, Ahmed; Hussain, Syed Fayyaz

    2005-02-01

    To assess the risk factors associated with development of ventilator associated pneumonia (VAP). A case control study. Intensive Care Unit (ICU) at the Aga Khan University Hospital, Karachi, between January 1999 and June 2000. All patients with assisted mechanical ventilation were assessed for the development of VAP. Risk factors associated with development of VAP were determined. Adult patients who developed pneumonia, 48 hours after ventilation, were called cases while those who did not develop pneumonia were called controls. Seventy (28%) out of 250 mechanically ventilated patients developed VAP (rate of VAP was 26 cases per 1000 ventilator days). Shock during first 48 hours of ventilation (odds ratio (OR), 5.95; 95% confidence interval (CI), 2.83-12.52), transport out of ICU during mechanical ventilation (OR, 6.0; 95% CI, 2.92-12.37), re-intubation (OR, 4.23; 95% CI, 2.53-9.85), prior episode of aspiration of gastric content (OR, 3.07; 95% CI, 1.35-7.01), and use of antibiotics prior to intubation (OR,2.55; 95% CI, 1.20-5.41) were found to be independently associated with a higher risk of developing VAP. Gram negative organisms and Staphylococcus aureus were responsible for over 90% of cases. Patients with VAP had higher crude mortality rate (57.1%) compared with controls (32.2%). Ventilator associated pneumonia is associated with a high mortality. This study has identified risk factors associated with VAP.

  6. Health risks associated with obesity

    African Journals Online (AJOL)

    annaline

    systemic hypertension are usually associated with severe cases.64. The exact mechanisms underlying the relationship between obesity and sleep apnoea are still unclear. It may be related to the effect of fat deposition on airway anatomy or changes in upper airway function.62 Weight loss has been shown to be associated ...

  7. Associative Learning Should Go Deep.

    Science.gov (United States)

    Mondragón, Esther; Alonso, Eduardo; Kokkola, Niklas

    2017-11-01

    Conditioning, how animals learn to associate two or more events, is one of the most influential paradigms in learning theory. It is nevertheless unclear how current models of associative learning can accommodate complex phenomena without ad hoc representational assumptions. We propose to embrace deep neural networks to negotiate this problem. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Bioinformatics of genomic association mapping

    NARCIS (Netherlands)

    Vaez Barzani, Ahmad

    2015-01-01

    In this thesis we present an overview of bioinformatics-based approaches for genomic association mapping, with emphasis on human quantitative traits and their contribution to complex diseases. We aim to provide a comprehensive walk-through of the classic steps of genomic association mapping

  9. African Diaspora Associations in Denmark

    DEFF Research Database (Denmark)

    Vammen, Ida Marie; Trans, Lars Ove

    2011-01-01

    Since the early 1990s, an increasing number of African migrants have come to Denmark, where they have formed a large number of migrant associations. This chapter presents selected findings from a comprehensive survey of African diaspora associations in Denmark and focuses specifically...

  10. Basic hue-meaning associations.

    Science.gov (United States)

    Moller, Arlen C; Elliot, Andrew J; Maier, Markus A

    2009-12-01

    Color may not only be pleasing to the eye, but may also carry important associations relevant for psychological functioning. Two experiments were conducted to test for basic hue-meaning associations, controlling for lightness and chroma. Specifically, we used a reaction time paradigm to test for links between red and green, and words that varied in achievement content (failure and success) or valence more generally. Results revealed that red was positively associated with failure and general negative words, and was negatively associated with success and general positive words, whereas green was positively associated with success words only. These findings directly document that hue carries psychologically relevant meaning. Implications both within and beyond the achievement domain are discussed.

  11. Building an Associative Classifier Based on Fuzzy Association Rules

    Directory of Open Access Journals (Sweden)

    Zuoliang Chen

    2008-08-01

    Full Text Available Classification based on association rules is considered to be effective and advantageous in many cases. However, there is a so-called qsharp boundaryq problem in association rules mining with quantitative attribute domains. This paper aims at proposing an associative classification approach, namely Classification with Fuzzy Association Rules (CFAR, where fuzzy logic is used in partitioning the domains. In doing so, the notions of support and confidence are extended, along with the notion of compact set in dealing with rule redundancy and conflict. Furthermore, the corresponding mining algorithm is introduced and tested on benchmarking datasets. The experimental results revealed that CFAR generated better understandability in terms of fewer rules and smother boundaries than the traditional CBA approach while maintaining satisfactory accuracy.

  12. Weak associativity and deformation quantization

    Science.gov (United States)

    Kupriyanov, V. G.

    2016-09-01

    Non-commutativity and non-associativity are quite natural in string theory. For open strings it appears due to the presence of non-vanishing background two-form in the world volume of Dirichlet brane, while in closed string theory the flux compactifications with non-vanishing three-form also lead to non-geometric backgrounds. In this paper, working in the framework of deformation quantization, we study the violation of associativity imposing the condition that the associator of three elements should vanish whenever each two of them are equal. The corresponding star products are called alternative and satisfy important for physical applications properties like the Moufang identities, alternative identities, Artin's theorem, etc. The condition of alternativity is invariant under the gauge transformations, just like it happens in the associative case. The price to pay is the restriction on the non-associative algebra which can be represented by the alternative star product, it should satisfy the Malcev identity. The example of nontrivial Malcev algebra is the algebra of imaginary octonions. For this case we construct an explicit expression of the non-associative and alternative star product. We also discuss the quantization of Malcev-Poisson algebras of general form, study its properties and provide the lower order expression for the alternative star product. To conclude we define the integration on the algebra of the alternative star products and show that the integrated associator vanishes.

  13. Weak associativity and deformation quantization

    International Nuclear Information System (INIS)

    Kupriyanov, V.G.

    2016-01-01

    Non-commutativity and non-associativity are quite natural in string theory. For open strings it appears due to the presence of non-vanishing background two-form in the world volume of Dirichlet brane, while in closed string theory the flux compactifications with non-vanishing three-form also lead to non-geometric backgrounds. In this paper, working in the framework of deformation quantization, we study the violation of associativity imposing the condition that the associator of three elements should vanish whenever each two of them are equal. The corresponding star products are called alternative and satisfy important for physical applications properties like the Moufang identities, alternative identities, Artin's theorem, etc. The condition of alternativity is invariant under the gauge transformations, just like it happens in the associative case. The price to pay is the restriction on the non-associative algebra which can be represented by the alternative star product, it should satisfy the Malcev identity. The example of nontrivial Malcev algebra is the algebra of imaginary octonions. For this case we construct an explicit expression of the non-associative and alternative star product. We also discuss the quantization of Malcev–Poisson algebras of general form, study its properties and provide the lower order expression for the alternative star product. To conclude we define the integration on the algebra of the alternative star products and show that the integrated associator vanishes.

  14. Weak associativity and deformation quantization

    Directory of Open Access Journals (Sweden)

    V.G. Kupriyanov

    2016-09-01

    Full Text Available Non-commutativity and non-associativity are quite natural in string theory. For open strings it appears due to the presence of non-vanishing background two-form in the world volume of Dirichlet brane, while in closed string theory the flux compactifications with non-vanishing three-form also lead to non-geometric backgrounds. In this paper, working in the framework of deformation quantization, we study the violation of associativity imposing the condition that the associator of three elements should vanish whenever each two of them are equal. The corresponding star products are called alternative and satisfy important for physical applications properties like the Moufang identities, alternative identities, Artin's theorem, etc. The condition of alternativity is invariant under the gauge transformations, just like it happens in the associative case. The price to pay is the restriction on the non-associative algebra which can be represented by the alternative star product, it should satisfy the Malcev identity. The example of nontrivial Malcev algebra is the algebra of imaginary octonions. For this case we construct an explicit expression of the non-associative and alternative star product. We also discuss the quantization of Malcev–Poisson algebras of general form, study its properties and provide the lower order expression for the alternative star product. To conclude we define the integration on the algebra of the alternative star products and show that the integrated associator vanishes.

  15. Weak associativity and deformation quantization

    Energy Technology Data Exchange (ETDEWEB)

    Kupriyanov, V.G., E-mail: vladislav.kupriyanov@gmail.com [CMCC-Universidade Federal do ABC, Santo André, SP (Brazil); Tomsk State University, Tomsk (Russian Federation)

    2016-09-15

    Non-commutativity and non-associativity are quite natural in string theory. For open strings it appears due to the presence of non-vanishing background two-form in the world volume of Dirichlet brane, while in closed string theory the flux compactifications with non-vanishing three-form also lead to non-geometric backgrounds. In this paper, working in the framework of deformation quantization, we study the violation of associativity imposing the condition that the associator of three elements should vanish whenever each two of them are equal. The corresponding star products are called alternative and satisfy important for physical applications properties like the Moufang identities, alternative identities, Artin's theorem, etc. The condition of alternativity is invariant under the gauge transformations, just like it happens in the associative case. The price to pay is the restriction on the non-associative algebra which can be represented by the alternative star product, it should satisfy the Malcev identity. The example of nontrivial Malcev algebra is the algebra of imaginary octonions. For this case we construct an explicit expression of the non-associative and alternative star product. We also discuss the quantization of Malcev–Poisson algebras of general form, study its properties and provide the lower order expression for the alternative star product. To conclude we define the integration on the algebra of the alternative star products and show that the integrated associator vanishes.

  16. Wavelet-based associative memory

    Science.gov (United States)

    Jones, Katharine J.

    2004-04-01

    Faces provide important characteristics of a person"s identification. In security checks, face recognition still remains the method in continuous use despite other approaches (i.e. fingerprints, voice recognition, pupil contraction, DNA scanners). With an associative memory, the output data is recalled directly using the input data. This can be achieved with a Nonlinear Holographic Associative Memory (NHAM). This approach can also distinguish between strongly correlated images and images that are partially or totally enclosed by others. Adaptive wavelet lifting has been used for Content-Based Image Retrieval. In this paper, adaptive wavelet lifting will be applied to face recognition to achieve an associative memory.

  17. The Associative Nature of Creativity

    DEFF Research Database (Denmark)

    Friis-Olivarius, Morten

    The overarching objective of this doctoral dissertation is to advance our understanding of the role of associations in creative thought and creativity training. While research in associative abilities and creativity has a long history and lies at the heart of many prevailing theories of creativity......, the exact details of how associations are formed and their involvement in creativity remains largely unexplored. The dissertation contains three original manuscripts: I: Morten Friis-Olivarius & Bo T. Christensen: CHange slows only the creative mind. II: Morten Friis-Olivarius, Oliver J. Hulme, Martin Skov...

  18. SMARANDACHE NON-ASSOCIATIVE RINGS

    OpenAIRE

    Vasantha, Kandasamy

    2002-01-01

    An associative ring is just realized or built using reals or complex; finite or infinite by defining two binary operations on it. But on the contrary when we want to define or study or even introduce a non-associative ring we need two separate algebraic structures say a commutative ring with 1 (or a field) together with a loop or a groupoid or a vector space or a linear algebra. The two non-associative well-known algebras viz. Lie algebras and Jordan algebras are mainly built using a vecto...

  19. HPV-Associated Cancers Statistics

    Science.gov (United States)

    ... What CDC Is Doing Related Links Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Vaginal and Vulvar Cancer Home HPV-Associated Cancer Statistics Language: English (US) Español (Spanish) Recommend on Facebook ...

  20. Business Associations and Private Ordering

    NARCIS (Netherlands)

    Prüfer, J.

    2012-01-01

    Abstract: We study the capacity of business associations - private, formal, noncommercial organizations designed to promote the common business interests of their members - to support contract enforcement and collective action. Inspired by recent empirical literature, our theoretical framework

  1. National Association of Social Workers

    Science.gov (United States)

    ... Join NASW today! What's New NASW Condemns President Trump's DACA Decision Decision to rescind Deferred Action for ... the vital services social workers provide. NASW monitoring Trump Election Commission The Association is concerned that the ...

  2. Brain Injury Association of America

    Science.gov (United States)

    ... com/Godspeed-Story-Pag.. Read More... BIAA Applauds Trump Administration's Opioid Emergency Declaration; Calls for More Resources ... The Brain Injury Association of America salutes the Trump Administration for directing the Department of Health and ...

  3. Benchmarking Complications Associated with Esophagectomy

    NARCIS (Netherlands)

    Low, Donald E.; Kuppusamy, Madhan Kumar; Alderson, Derek; Cecconello, Ivan; Chang, Andrew C.; Darling, Gail; Davies, Andrew; D'journo, Xavier Benoit; Gisbertz, Suzanne S.; Griffin, S. Michael; Hardwick, Richard; Hoelscher, Arnulf; Hofstetter, Wayne; Jobe, Blair; Kitagawa, Yuko; Law, Simon; Mariette, Christophe; Maynard, Nick; Morse, Christopher R.; Nafteux, Philippe; Pera, Manuel; Pramesh, C. S.; Puig, Sonia; Reynolds, John V.; Schroeder, Wolfgang; Smithers, Mark; Wijnhoven, B. P. L.

    2017-01-01

    Utilizing a standardized dataset with specific definitions to prospectively collect international data to provide a benchmark for complications and outcomes associated with esophagectomy. Outcome reporting in oncologic surgery has suffered from the lack of a standardized system for reporting

  4. Neoplasm associated with chagasic megaesophagus

    International Nuclear Information System (INIS)

    Pereira, A.B.; Barros, N. de; Souza Rocha, M. de; Cerri, G.G.; Cecconello, I.; Pinotti, H.W.; Almeida Magalhaes, A. de

    1990-01-01

    Two cases of chagasic megaesophagus associated with neoplasia are presented in this article: one with early and another with advanced neoplasia. Comments on their clinic, endoscopic and radiologic examinations are presented. Computerized tomography and anatomopathologic findings are also discussed and reviewed. We emphasize on the need of a previous esophagic preparation for the radiological examination in order to obtain an adequate diagnosis of neoplasia associated with megaesophagus mainly in the early phase of the disease. (author)

  5. Vitiligo associated with esophageal adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Ali Asilian

    2013-01-01

    Full Text Available Vitiligo is a disease that results in depigmented areas in the skin. It may develop at any age but the average age at onset is 20 years. Association of vitiligo and melanoma has been commonly reported, but malignancies other than melanoma have been rarely associated with vitiligo. We report a 73-year-old patient with new onset vitiligo who developed esophageal adenocarcinoma in the following years.

  6. Ovarian carcinoma associated with endometriosis.

    Science.gov (United States)

    Boyraz, Gokhan; Selcuk, Ilker; Yazıcıoğlu, Aslıhan; Tuncer, Zafer Selçuk

    2013-09-01

    Previous studies have suggested an association between endometriosis and development of ovarian cancer. A study was performed to evaluate the cases of ovarian carcinoma associated with endometriosis. The study includes patients with ovarian carcinoma associated with endometriosis diagnosed between 2000 and 2010 at Hacettepe University Hospital, Ankara, Turkey. A total of 1086 patients who underwent surgical staging for ovarian carcinoma were analyzed retrospectively for the presence of histologically documented endometriosis. The clinical and pathological characteristics of 45 ovarian carcinoma patients associated with endometriosis were evaluated including histologic subtype, stage and grade. Ovarian carcinoma was found to be associated with endometriosis in 4.1% (45/1086) of the cases. Of them, 17 patients (37.8%) had clear cell, 15 (33.3%) had endometrioid, 6 (13.3%) had serous papillary, 4 (8.9%) had mucinous and the remaining 3 patients had an undifferentiated subtype of ovarian carcinoma. Twenty-three (51.1%) patients had stage I, 4 (8.9%) had stage II and 18 (40.0%) had stage III disease. The frequency of coexistence of endometriosis was 20.4% (17/83) for clear cell carcinoma and 9.3% (15/161) for endometrioid cell carcinoma. Only a small proportion of ovarian cancer cases were found to be associated with endometriosis. Endometriosis was most frequently associated with clear cell and endometrioid types of ovarian carcinoma. Ovarian carcinoma associated with endometriosis seems to represent a distinct disease entity with different histological subtypes, early presentation and a relatively favorable outcome. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  7. The Associative Nature of Creativity

    DEFF Research Database (Denmark)

    Friis-Olivarius, Morten

    The overarching objective of this doctoral dissertation is to advance our understanding of the role of associations in creative thought and creativity training. While research in associative abilities and creativity has a long history and lies at the heart of many prevailing theories of creativit......, Thomas Z. Ramsøy, Hartwig Siebner: Viewing objects activates the creative mind. III: Balder Onarheim & Morten Friis-Olivarius (2013): Applying the neuroscience of creativity to creativity training. Frontiers in Human Neuroscience, Volume 7, Article 656...

  8. Insomnia: prevalence and associated factors

    OpenAIRE

    Lopes, Cátia; Lopes, Daniela; Ferreira, Sofia; Correia, Teresa; Pinto, Isabel C.

    2014-01-01

    Nowadays sleep disorders are very common and affect most of the population, the most common may be insomnia. Insomnia is defined as the difficulty of initiating or maintaining sleep it, may also be reflected in an early wake up and by the presence of a non-restful sleep and it is associated with impairment in social and occupational functioning of the individual. Knowing the prevalence and the associated factors of insomnia. This is a cross-sectional epidemiological study. The pop...

  9. Healthcare-associated atypical pneumonia.

    Science.gov (United States)

    Forgie, Sarah; Marrie, Thomas J

    2009-02-01

    Atypical pneumonia was first described in 1938, and over time, Mycoplasma, Legionella, and Chlamydophila were the agents commonly linked with community-associated atypical pneumonia. However, as technology has improved, so has our understanding of this clinical entity. It is now known that there are many agents linked with atypical pneumonia in the community, and many of these agents are also major causes of healthcare-associated pneumonia. This article discusses the history, epidemiology, and pathogenesis of infection; control of infection; clinical findings; diagnosis; and, where applicable, treatment of the agents of healthcare-associated atypical pneumonia. Bacterial agents include Legionella species, Mycoplasma pneumoniae, Chlamydophila species, and Coxiella burnetii. Although there are over 100 viruses that can cause respiratory tract infections, only a fraction of those have been defined in the context of healthcare-associated atypical pneumonia: adenovirus and human bocavirus (HBoV); rhinovirus; human coronaviruses (HCoV), including HCoV 229E, HCoV OC43, HCoV NL63, HCoV HKU1; members of the paramyxoviridae (parainfluenza viruses, human metapneumovirus, and respiratory syncytial virus); hantavirus; influenza; and severe acute respiratory syndrome (SARS) Co-V. Our knowledge about healthcare-associated atypical pneumonia will continue to evolve as newer pathogens are identified and as newer diagnostic modalities such as multiplex polymerase chain reaction are introduced.

  10. HIV-associated neurocognitive disorder.

    Science.gov (United States)

    Clifford, David B

    2017-02-01

    HIV-associated neurocognitive disease is the most active topic for neuroAIDS investigations at present. Although impairment is mild in patients successfully treated with modern antiviral regimens, it remains an ongoing problem for HIV patients. It is important to update the emerging research concerning HIV-associated neurocognitive disease. The virus enters the brain during acute infection, with evidence for abnormal functioning that may occur early and often persists. Direct relationships with ongoing viral infection continue to be monitored, but chronic inflammation often associated with monocytes and macrophages appears to be the most likely driver of cognitive dysfunction. Appreciation for cerebrovascular disease as a significant comorbidity that is associated with cognitive deficits is increasing. Neuroimaging is actively being developed to address detection and measurement of changes in the brain. Optimal combined antiretroviral treatment therapy has vastly improved neurologic outcomes, but so far has not been demonstrated to reverse the remaining mild impairment. Inflammatory and vascular mechanisms of cerebral dysfunction may need to be addressed to achieve better outcomes. Ongoing research is required to improve neurological outcomes for persons living with HIV. It is likely that interventions beyond antiviral approaches will be required to control or reverse HIV-associated neurocognitive disease.

  11. Extracurricular associations and college enrollment.

    Science.gov (United States)

    Gibbs, Benjamin G; Erickson, Lance D; Dufur, Mikaela J; Miles, Aaron

    2015-03-01

    There is consistent evidence that student involvement in extracurricular activities (EAs) is associated with numerous academic benefits, yet understanding how peer associations within EAs might influence this link is not well understood. Using Add Health's comprehensive data on EA participation across 80 schools in the United States, we develop a novel measure of peer associations within EA activities. We find that EA participation with high achieving peers has a nontrivial link to college enrollment, even after considering individual, peer, and school-level factors. This suggests that school policies aimed at encouraging student exposure to high achieving peers in EAs could have an important impact on a student's later educational outcomes. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. The Staff Association and you

    CERN Multimedia

    Association du personnel

    2013-01-01

    The Staff Association, your representative with the Management and the Member States The article VII 1.01 of the Staff Rules and Regulations (SR&R) provides that “the relations between the Director-General and the personnel shall be established either on an individual basis or on a collective basis with the Staff Association as intermediary”. This essential role of the Staff representatives, of being the spokesperson of the entire staff of the Organization vis-à-vis the Director-General and the Members States, is achieved through regular participation in the various joint advisory committees defined in the SR&R. The most important are the Standing Concertation Committee and the TREF, tripartite forum where your representatives meet with the Member States delegates, in the presence of the Management, to explain the position of the staff on the various issues concerning employment conditions. The Finance Committee also gives the opportunity to the Staff Association to ...

  13. Self-associating autotransporters, SAATs

    DEFF Research Database (Denmark)

    Klemm, Per; Vejborg, Rebecca Munk; Sherlock, O.

    2006-01-01

    autoaggregation factor found in the majority of E. coli strains. The three proteins exhibit approximately 25% identity at the sequence level, and are quite different with respect to size, glycosylation and processing. Nevertheless, they share some important properties: all are self-associating proteins that cause...... with the widespread presence of these proteins. The group encompasses many important virulence factors. In Escherichia coli, a subgroup of autotransporter proteins consists of the TibA adhesin/invasin associated with some enterotoxigenic E. coli, the AIDA adhesin from diarrhea-causing E. coli and finally, the Ag43...... bacterial aggregation. They can also interact with each other via heterologous interactions to cause formation of mixed bacterial aggregates. Furthermore, these proteins enhance biofilm formation. Based on these properties we propose to classify them together in a group termed SAATs: self-associating...

  14. Global Employer and Business Associations

    DEFF Research Database (Denmark)

    Ronit, Karsten

    2016-01-01

    Global employer and business associations at the peak level are neglected in research, but this paper argues that it is possible to develop collective action and represent interests in many policy fields through these encompassing entities, and they add to other forms of global business...... coordination. This study analyses all the global peak associations (International Chamber of Commerce, International Organisation of Employers, World Chambers Federation, Business and Industry Advisory Committee to the OECD, B20 Coalition, World Economic Forum and World Business Council for Sustainable...... implications for our understanding of global politics where new approaches are needed to analyse the institutionalisation of business interests....

  15. Rhombencephalitis associated with Dengue fever.

    Science.gov (United States)

    Verma, Rajesh; Bharti, Kavita; Mehta, Mannan; Bansod, Amrit

    2016-05-01

    Dengue infection is gradually disseminating throughout the world in alarming proportions. It is a arbovirus infection,transmitted by aedes mosquitoes. It is a multi-systemic disorder associated with varied neurological complications. There is increased trend of development of neurological complications in dengue fever. The neurological complications arising due to dengue infection can be categorized into central and neuromuscular complications. The central nervous system disorders reported with dengue fever are encephalopathy,encephalitis and myelitis.Here we report a case of rhombencephalitis associated with dengue fever. The literature does not mention rhombencephalitis occurring with dengue illness. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Asymptotics for Associated Random Variables

    CERN Document Server

    Oliveira, Paulo Eduardo

    2012-01-01

    The book concerns the notion of association in probability and statistics. Association and some other positive dependence notions were introduced in 1966 and 1967 but received little attention from the probabilistic and statistics community. The interest in these dependence notions increased in the last 15 to 20 years, and many asymptotic results were proved and improved. Despite this increased interest, characterizations and results remained essentially scattered in the literature published in different journals. The goal of this book is to bring together the bulk of these results, presenting

  17. Papulonecrotic tuberculids associated with uveitis

    International Nuclear Information System (INIS)

    Dar, N.R.; Raza, N.

    2008-01-01

    Papulonecrotic tuberculids represent an immunological expression of an internal focus of tuberculosis in an individual with a moderate or high degree of immunity. It responds to anti-tuberculosis treatment and is characterized by an eruption of necrotizing papules occurring in symmetrical crops, particularly affecting the elbows, knees, buttocks and face. A case of papulonecrotic tuberculids associated with immune mediated unilateral uveitis is reported in which all investigations were negative for tuberculosis except a strongly positive tuberculin test. There was an excellent response to anti-tuberculosis treatment. The association of immune mediated uveitis with papulonecrotic tuberculids has not been described before. (author)

  18. Pregnancy-associated Breast Cancer.

    Science.gov (United States)

    Case, Ashley S

    2016-12-01

    Breast cancer is one of the most common malignancies affecting pregnancy. Pregnancy-associated breast cancer refers to breast cancer that is diagnosed during pregnancy or within the first postpartum year. The incidence is increasing as more women delay childbearing. Breast cancer can be safely diagnosed, staged, and treated during pregnancy while protecting the fetus and mother with excellent outcomes for both. Avoiding diagnostic delays is vital to prognosis. This article provides an overview of the diagnosis, staging, management, and prognosis of pregnancy-associated breast cancer. Relevant current literature is reviewed.

  19. The Ontario Energy Marketers Association

    Energy Technology Data Exchange (ETDEWEB)

    Baker, W.F.C. [Ontario Energy Marketers Association, ON (Canada)

    1998-12-31

    An overview of the role of the Ontario Energy Marketers Association (OEMA) and its future orientation was presented. Participants in the OEMA include agents, brokers, marketers, local distribution companies, public interest representatives, associations and government representatives. The role of the OEMA is to encourage open competition for the benefit and protection of all energy consumer and market participants. As well, the OEMA serves as a forum for key industry stakeholders to resolve market issues outside the regulatory arena, set standards and codes of practice, establish customer education programs, and develop industry input into public policy making.

  20. Updating optical pseudoinverse associative memories.

    Science.gov (United States)

    Telfer, B; Casasent, D

    1989-07-01

    Selected algorithms for adding to and deleting from optical pseudoinverse associative memories are presented and compared. New realizations of pseudoinverse updating methods using vector inner product matrix bordering and reduced-dimensionality Karhunen-Loeve approximations (which have been used for updating optical filters) are described in the context of associative memories. Greville's theorem is reviewed and compared with the Widrow-Hoff algorithm. Kohonen's gradient projection method is expressed in a different form suitable for optical implementation. The data matrix memory is also discussed for comparison purposes. Memory size, speed and ease of updating, and key vector requirements are the comparison criteria used.

  1. Delineating SPTAN1 associated phenotypes

    DEFF Research Database (Denmark)

    Syrbe, Steffen; Harms, Frederike L; Parrini, Elena

    2017-01-01

    De novo in-frame deletions and duplications in the SPTAN1 gene, encoding the non-erythrocyte αII spectrin, have been associated with severe West syndrome with hypomyelination and pontocerebellar atrophy. We aimed at comprehensively delineating the phenotypic spectrum associated with SPTAN1...... contact site exhibited severe and progressive brain, brainstem and cerebellar atrophy, with hypomyelination in most. We used fibroblasts from five patients to study spectrin aggregate formation by Triton-X extraction and immunocytochemistry followed by fluorescence microscopy. αII/βII aggregates and α...

  2. Beyond Intra-Transaction Association Analysis: Mining Multi-Dimensional Inter-Transaction Association Rules

    NARCIS (Netherlands)

    Lu, H.J.; Feng, L.; Han, J.W.

    2000-01-01

    In this paper, we extend the scope of mining association rules from traditional single-dimensional intratransaction associations, to multidimensional intertransaction associations. Intratransaction associations are the associations among items with the same transaction, where the notion of the

  3. The International Big History Association

    Science.gov (United States)

    Duffy, Michael; Duffy, D'Neil

    2013-01-01

    IBHA, the International Big History Association, was organized in 2010 and "promotes the unified, interdisciplinary study and teaching of history of the Cosmos, Earth, Life, and Humanity." This is the vision that Montessori embraced long before the discoveries of modern science fleshed out the story of the evolving universe. "Big…

  4. Associated jet production at HERA

    CERN Document Server

    Bartels, Julius; de Roeck, A; Graudenz, Dirk; Wüsthoff, M

    1996-01-01

    We compare the BFKL prediction for the associated production of forward jets at HERA with fixed-order matrix element calculations taking into account the kinematical cuts imposed by experimental conditions. Comparison with H1 data of the 1993 run favours the BFKL prediction. As a further signal of BFKL dynamics, we propose to look for the azimuthal dependence of the forward jets.

  5. Montessori Transformation at Computer Associates.

    Science.gov (United States)

    Mars, Lisa

    2002-01-01

    Describes the growth of the all-day Montessori program for children ages 6 weeks to 6 years at Computer Associates' corporate headquarters and multiple sites worldwide. Focuses on placement of AMI Montessori-trained teachers, refurbishing of the child development centers to fit Montessori specifications, and the Nido--the children's community--and…

  6. Pseudobulbar palsy associated with trismus.

    OpenAIRE

    Lai, M. M.; Howard, R. S.

    1994-01-01

    A 60 year old patient presented with an acute pseudobulbar palsy associated with trismus. A computed tomography scan revealed low attenuation areas consistent with infarction affecting the genu of the internal capsules bilaterally. Trismus has not previously been described as the presenting feature of a pseudobulbar palsy.

  7. Pseudobulbar palsy associated with trismus.

    Science.gov (United States)

    Lai, M. M.; Howard, R. S.

    1994-01-01

    A 60 year old patient presented with an acute pseudobulbar palsy associated with trismus. A computed tomography scan revealed low attenuation areas consistent with infarction affecting the genu of the internal capsules bilaterally. Trismus has not previously been described as the presenting feature of a pseudobulbar palsy. Images Figure 1 PMID:7824418

  8. Multiple sclerosis associated with trismus.

    Science.gov (United States)

    D'Costa, D. F.; Vania, A. K.; Millac, P. A.

    1990-01-01

    This report describes the case history of a middle-aged lady who presented with symptoms and signs over one year leading to a diagnosis of multiple sclerosis. During one of her relapses, she developed trismus--an association that has not been described before in multiple sclerosis. PMID:2099430

  9. Spectrophotometric determination of association constant

    DEFF Research Database (Denmark)

    2016-01-01

    Least-squares 'Systematic Trial-and-Error Procedure' (STEP) for spectrophotometric evaluation of association constant (equilibrium constant) K and molar absorption coefficient E for a 1:1 molecular complex, A + B = C, with error analysis according to Conrow et al. (1964). An analysis of the Charg...

  10. Lynch syndrome-associated neoplasms

    DEFF Research Database (Denmark)

    Shia, Jinru; Holck, Susanne; Depetris, Giovanni

    2013-01-01

    of such information. This article provides an overview of the development of histopathology and immunohistochemistry in Lynch syndrome-associated tumors, particularly in colorectal and endometrial cancers, and outlines the issues and current status of these specific pathologic aspects in not only the major tumors...

  11. Statin-Associated Side Effects.

    Science.gov (United States)

    Thompson, Paul D; Panza, Gregory; Zaleski, Amanda; Taylor, Beth

    2016-05-24

    Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well tolerated, but associated with various statin-associated symptoms (SAS), including statin-associated muscle symptoms (SAMS), diabetes mellitus (DM), and central nervous system complaints. These are "statin-associated symptoms" because they are rare in clinical trials, making their causative relationship to statins unclear. SAS are, nevertheless, important because they prompt dose reduction or discontinuation of these life-saving mediations. SAMS is the most frequent SAS, and mild myalgia may affect 5% to 10% of statin users. Clinically important muscle symptoms, including rhabdomyolysis and statin-induced necrotizing autoimmune myopathy (SINAM), are rare. Antibodies against HMG-CoA reductase apparently provoke SINAM. Good evidence links statins to DM, but evidence linking statins to other SAS is largely anecdotal. Management of SAS requires making the possible diagnosis, altering or discontinuing the statin treatment, and using alternative lipid-lowering therapy. Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  12. Association between methylenetetrahydrofolate reductase (MTHFR ...

    African Journals Online (AJOL)

    Association between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and risk of ischemic stroke in North Indian population: A hospital based case–control study. Amit Kumar, Shubham Misra, Anjali Hazarika, Pradeep Kumar, Ram Sagar, Abhishek Pathak, Kamalesh Chakravarty, Kameshwar ...

  13. Hypothyroidism associated with parathyroid disorders.

    Science.gov (United States)

    Mantovani, Giovanna; Elli, Francesca Marta; Corbetta, Sabrina

    2017-03-01

    Hypothyroidism may occur in association with congenital parathyroid disorders determining parathyroid hormone insufficiency, which is characterized by hypocalcemia and concomitant inappropriately low secretion of parathormone (PTH). The association is often due to loss of function of genes common to thyroid and parathyroid glands embryonic development. Hypothyroidism associated with hypoparathyroidism is generally mild and not associated with goiter; moreover, it is usually part of a multisystemic involvement not restricted to endocrine function as occurs in patients with 22q11 microdeletion/DiGeorge syndrome, the most frequent disorders. Hypothyroidism and hypoparathyroidism may also follow endocrine glands' damages due to autoimmunity or chronic iron overload in thalassemic disorders, both genetically determined conditions. Finally, besides PTH deficiency, hypocalcemia can be due to PTH resistance in pseudohypoparathyroidism; when hormone resistance is generalized, patients can suffer from hypothyroidism due to TSH resistance. In evaluating patients with hypothyroidism and hypocalcemia, physical examination and clinical history are essential to drive the diagnostic process, while routine genetic screening is not recommended. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Canine Copper-Associated Hepatitis

    NARCIS (Netherlands)

    Dirksen, Karen|info:eu-repo/dai/nl/412424428; Fieten, Hille|info:eu-repo/dai/nl/314112596

    2017-01-01

    Copper-associated hepatitis is recognized with increasing frequency in dogs. The disease is characterized by centrolobular hepatic copper accumulation, leading to hepatitis and eventually cirrhosis. The only way to establish the diagnosis is by histologic assessment of copper distribution and copper

  15. MURCS Association: a Case Report

    African Journals Online (AJOL)

    rme

    infancy, the child presented with the skeletal deformities, recurrent urinary tract infections ... features of this syndrome in association with right deviation of anorectal canal, subglottic stenosis and unilateral oblique inguinal hernia. ... syndactyly between index and middle fingers. Both lower limbs showed talipus and club ...

  16. Spina Bifida Association of America

    Science.gov (United States)

    Exceptional Parent, 1974

    1974-01-01

    The Statement of the Spina Bifida Association of America (SBAA) explains SB as a malformation of the central nervous system, reports the formation of SBAA in 1974, explains SBAA's emphasis on local chapter organization, and describes SBAA services, including a bimonthly publication, public education efforts, and research validation projects. (GW)

  17. Differential Association and Marijuana Use.

    Science.gov (United States)

    Griffin, Brenda S.; Griffin, Charles T.

    Edwin Sutherland's differential association theory was posited to explain all types of criminal or delinquent behavior. While research efforts have generally been confined to a focus on general criminal or delinquent behavior of the individual, it appears that the theory may also be applied to specific criminal or delinquent acts such as marijuana…

  18. Chromosomal abnormalities associated with omphalocele.

    Science.gov (United States)

    Chen, Chih-Ping

    2007-03-01

    Fetuses with omphalocele have an increased risk for chromosomal abnormalities. The risk varies with maternal age, gestational age at diagnosis, association with umbilical cord cysts, complexity of associated anomalies, and the contents of omphalocele. There is considerable evidence that genetics contributes to the etiology of omphalocele. This article provides an overview of chromosomal abnormalities associated with omphalocele and a comprehensive review of associated full aneuploidy such as trisomy 18, trisomy 13, triploidy, trisomy 21, 45,X, 47,XXY, and 47,XXX, partial aneuploidy such as dup (3q), dup (11p), inv (11), dup (1q), del (1q), dup (4q), dup (5p), dup (6q), del (9p), dup (15q), dup(17q), Pallister-Killian syndrome with mosaic tetrasomy 12p and Miller-Dieker lissencephaly syndrome with deletion of 17p13.3, and uniparental disomy (UPD) such as UPD 11 and UPD 14. Omphalocele is a prominent marker for chromosomal abnormalities. Perinatal identification of omphalocele should alert chromosomal abnormalities and familial unbalanced translocations, and prompt thorough cytogenetic investigations and genetic counseling.

  19. Macroinvertebrate communities associated with duckweed ...

    African Journals Online (AJOL)

    The functional feeding groups and diversity of macroinvertebrate communities associated with duckweed mats in the New Years River (two sites) and Bloukrans River (two sites), Eastern Cape province, South Africa, were assessed. Duckweed (Lemnaceae) is a ubiquitous family of floating macrophytes. A total of 41 ...

  20. Chromosomal Abnormalities Associated With Omphalocele

    Directory of Open Access Journals (Sweden)

    Chih-Ping Chen

    2007-03-01

    Full Text Available Fetuses with omphalocele have an increased risk for chromosomal abnormalities. The risk varies with maternal age, gestational age at diagnosis, association with umbilical cord cysts, complexity of associated anomalies, and the contents of omphalocele. There is considerable evidence that genetics contributes to the etiology of omphalocele. This article provides an overview of chromosomal abnormalities associated with omphalocele and a comprehensive review of associated full aneuploidy such as trisomy 18, trisomy 13, triploidy, trisomy 21, 45,X, 47,XXY, and 47,XXX, partial aneuploidy such as dup(3q, dup(11p, inv(11, dup(1q, del(1q, dup(4q, dup(5p, dup(6q, del(9p, dup(15q, dup(17q, Pallister-Killian syndrome with mosaic tetrasomy 12p and Miller-Dieker lissencephaly syndrome with deletion of 17p13.3, and uniparental disomy (UPD such as UPD 11 and UPD 14. Omphalocele is a prominent marker for chromosomal abnormalities. Perinatal identification of omphalocele should alert chromosomal abnormalities and familial unbalanced translocations, and prompt thorough cytogenetic investigations and genetic counseling.

  1. Microfibrillar-Associated Protein 4

    DEFF Research Database (Denmark)

    Sækmose, Susanne Gjørup; Mössner, Belinda; Christensen, Peer Brehm

    2015-01-01

    BACKGROUND AND AIMS: A method for assessment of liver fibrosis and cirrhosis without the need for a liver biopsy is desirable. Microfibrillar-associated protein 4 (MFAP4) is a suggested biomarker for identification of high-risk patients with severe fibrosis stages. This study aimed to examine...

  2. Microfibrillar-associated protein 4

    DEFF Research Database (Denmark)

    Johansson, Sofie Lock; Roberts, Nassim Bazeghi; Schlosser, Anders

    2014-01-01

    BACKGROUND: Microfibrillar-associated protein 4 (MFAP4) is a matricellular glycoprotein that co-localises with elastic fibres and is highly expressed in the lungs. The aim of this study was to test the hypothesis that plasma MFAP4 (pMFAP4) reflects clinical outcomes in chronic obstructive pulmonary...

  3. THE AFRICAN ASSOCIATION FOR LEXICOGRAPHY

    African Journals Online (AJOL)

    Riette Ruthven

    She also made a big pottery AFRILEX emblem to be used by the. Association during conferences or other events. AFRILEX recognises special contributions that were made by members in honour or on behalf of AFRILEX (e.g. being a chairperson for a number of years). Deserving members are presented with a certificate of ...

  4. ERP correlates of associative learning.

    Science.gov (United States)

    Rose, M; Verleger, R; Wascher, E

    2001-05-01

    We examined changes of event-related potentials (ERPs) while participants learned stimulus-to-stimulus relations in an S1-S2 task. The design allowed for separating processes of associative learning from nonspecific effects. Participants had to respond to S2 by a left or right key-press dependent on S2 identity (letter W or M). Preparation for S2 could be improved by using the associative information given by S1. The S1 was an arrow pointing to the left or right. In combination with its color, arrow direction was informative about location and identity of S2, but participants were not informed about the relevance of color. Arrows in two of the colors were fully predictive for the S2 whereas the third color gave no valid information. This third stimulus controlled for habituation and procedural learning. Six blocks with 200 trials each and all three S1 colors in random order were presented. Behavioral and ERP differences in each block between "learning" and control trials were used to identify processes of associative learning. Several effects of associative learning were identified indicating the involvement of specific stages of information processing: a continuous increase of P3 amplitude evoked by S1 was accompanied by a decrease of P3 evoked by S2. These changes reflected the modifications of stimulus weights for response selection and the strengthened association between the two stimulus complexes in the time course of learning. The related motor preparation benefited from learning too, expressed in a decrease of CNV amplitude and an increase of LRP amplitude. Finally a decrease of N1 amplitude evoked by S2 indicated the reduced need to allocate spatial attention to the S2 location according to the learned meaning of S1.

  5. Automatic controller at associated memory

    International Nuclear Information System (INIS)

    Courty, P.

    1977-06-01

    Organized around an A2 type controller, this CAMAC device allows on command of the associated computer to start reading 64K 16 bit words into an outer memory. This memory is fully controlled by the computer. In the automatic mode, which works at 10 6 words/sec, the computer can access any other module of the same crate by cycle-stealing [fr

  6. Mirror Neurons from Associative Learning

    OpenAIRE

    Catmur, Caroline; Press, Clare; Heyes, Cecilia

    2016-01-01

    Mirror neurons fire both when executing actions and observing others perform similar actions. Their sensorimotor matching properties have generally been considered a genetic adaptation for social cognition; however, in the present chapter we argue that the evidence in favor of this account is not compelling. Instead we present evidence supporting an alternative account: that mirror neurons’ matching properties arise from associative learning during individual development. Notably, this proces...

  7. American Psychological Association annual report.

    Science.gov (United States)

    2010-01-01

    Presents the 2009 American Psychological Association annual report. It highlights a very important year for APA and psychology by summarizing activities within each directorate. It describes strides made toward the goal of infusing psychology into the health care marketplace and of bringing psychology-and the unique skills of psychologists-to the attention of the public. This report aims to give insight into the contributions psychologists make to our communities and our country. 2010 APA, all rights reserved.

  8. Distributed and associative working memory.

    Science.gov (United States)

    Zhou, Yong-Di; Ardestani, Allen; Fuster, Joaquín M

    2007-09-01

    This study explores the cortical cell dynamics of unimodal and cross-modal working memory (WM). Neuronal activity was recorded from parietal areas of monkeys performing delayed match-to-sample tasks with tactile or visual samples. Tactile memoranda (haptic samples) consisted of rods with differing surface features (texture or orientation of ridges) perceived by active touch. Visual memoranda (icons) consisted of striped patterns of differing orientation. In a haptic-haptic task, the animal had to retain through a period of delay the surface feature of the sample rod to select a rod that matched it. In a visual-haptic task, the animal had to retain the icon for the haptic choice of a rod with ridges of the same orientation as the icon's stripes. Units in all areas responded with firing change to one or more task events. Also in all areas, cells responded differently to different sample memoranda. Differential sample coherent firing was present in most areas during the memory period (delay). It is concluded that neurons in somatosensory and association areas of parietal cortex participate in broad networks that represent various task events and stimuli (auditory, motor, proprioceptive, tactile, and visual). Neurons in the same networks take part in retaining in WM the memorandum for each trial, whether it is encoded haptically or visually. The VH association by parietal cells in WM is analogous to the auditory-visual association previously observed in prefrontal cortex. Both illustrate the capacity of cortical neurons to associate sensory information across time and across modalities in accord with the rules of a behavioral task.

  9. Paliperidone-associated motor tics.

    Science.gov (United States)

    Hsieh, Ming-Han; Chiu, Nan-Ying

    2014-01-01

    Paliperidone-associated motor tics. Case report. We report a 30-year-old man with schizophrenia who developed motor tics (eye blinking) after treatment of paliperidone up to 15 mg daily. Tic-like symptoms, from simple eye blinking to complex Tourette-like syndrome, may occur during paliperidone treatment, especially with high dose. Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.

  10. Variables associated with active spondylolysis.

    Science.gov (United States)

    Gregg, Chris D; Dean, Sarah; Schneiders, Anthony G

    2009-11-01

    Retrospective non-experimental study. To investigate variables associated with active spondylolysis. A retrospective study audited clinical data over a two year period from patients with suspected spondylolysis that were referred for a SPECT bone scan. Six exploratory variables were identified and analysed using uni- and multi-variate regression from 82 patient records to determine the association between symptomatic, physical and demographic characteristics, and the presence of an active spondylolysis. Tertiary level multidisciplinary private practice sports medicine clinic. All patients with low back pain that required a SPECT bone scan to confirm suspected spondylolysis. 82 subjects were included in the final sample group. The six exploratory variables included Age, Gender, Injury duration, Injury onset, Sports participation and the result of the Single Leg Hyperextension Test. The dependent outcome variable was the result of the SPECT bone scan (scan-positive or scan-negative). Adolescent males had a higher incidence of spondylolysis detected by SPECT bone scan compared to other patients and a statistically significant association was demonstrated for both age (p=0.01) and gender (p=0.01). Subjects with an active spondylolysis were nearly five times more likely to be male and aged less than 20 years. Furthermore, the likelihood ratio indicated that adolescent males with suspected spondylolysis were three and a half times more likely to have a positive bone scan result. The Single Leg Hyperextension Test did not demonstrate a statistically significant association with spondylolysis (p=0.47). Clinicians assessing for a predisposition to the development of spondylolysis should consider the gender and age of the patient and not rely on the predictive ability of the Single Leg Hyperextension Test.

  11. Hepatitis C-associated arthritis.

    Science.gov (United States)

    Buskila, D

    2000-07-01

    Rheumatologic complications of hepatitis C virus (HCV) infection are common and include mixed cryoglobulinemia, vasculitis, sicca symptoms, myalgia, arthritis, and fibromyalgia. The prevalence of cryoglobulinemia in Sweden and Germany is much lower compared with data from southern Europe. Viral, genetic, or environmental factors may be responsible for such a difference in prevalence. There is no single clinical picture of arthritis in patients with HCV infection. There is a well-defined picture of arthritis associated with the presence of mixed cryoglobulinemia that consists of an intermittent mono- or oligoarticular, nondestructive arthritis affecting large and medium-size joints. Involvement of salivary and lacrimal glands is common in HCV-infected subjects, but HCV antigens are not detected in affected glands. HCV-infected subjects express a high prevalence of a variety of autoantibodies, usually in low titers. The clinical significance of most of these autoantibodies is not clear. The prevalence and titer of these autoantibodies are unaffected by interferon-alpha therapy. Several studies have attempted to assess whether HCV infection may be involved in the etiopathogenesis of rheumatic and autoimmune diseases. The results of most of these studies do not support the idea that HCV infection may play a pathogenic role in the development of systemic lupus erythematosus, antiphospholipid syndrome, or leukocytoclastic vasculitis. Experience treating patients with HCV-associated arthritis is limited and treatment remains controversial. No major therapeutic trials in HCV-associated arthritis were reported in the past 2 years.

  12. HIV-associated neurocognitive disorders

    Directory of Open Access Journals (Sweden)

    Zahir Vally

    2011-12-01

    Full Text Available HIV infection is associated with disturbances in brain function referred to as HIV-associated neurocognitive disorders (HAND. This literature review outlines the recently revised diagnostic criteria for the range of HAND from the earliest to the more advanced stages: (i asymptomatic neurocognitive impairment; (ii mild neurocognitive disorder; and (iii HIV-associated dementia. Relevant literature is also reviewed regarding the differential impact upon component cognitive domains known to be affected in HAND, which in turn should ideally be targeted during clinical and neuropsychological assessments: psychomotor and information processing speed, learning and memory, attention and working memory, speech and language, executive functioning and visuospatial functioning. A discussion outlining the neuropsychological tools used in the diagnostic screening of HAND is also included. The central mechanisms of HAND appear to revolve primarily around psychomotor slowing and cognitive control over mental operations, possibly reflecting the influence of disrupted fronto-striatal circuits on distributed neural networks critical to cognitive functions. The accurate assessment and diagnosis of HAND depends on meeting the need for statistically sound neuropsychological assessment techniques that may be used confidently in assessing South African populations, as well as the development of relevant norms for comparison of test performance data.

  13. association inhibition by transferrin.

    Science.gov (United States)

    Raditsis, Annie V; Milojevic, Julijana; Melacini, Giuseppe

    2013-07-16

    The iron-transport glycoprotein transferrin has recently been shown to serve as a potent inhibitor of Aβ self-association. Although this novel, to our knowledge, inhibitory function of transferrin is of potential therapeutic interest for the treatment of Alzheimer's disease, the underlying mechanism is still not fully understood. Although it has been shown that the Fe(III) sequestration by transferrin reduces oxidative damage and Aβ aggregation, it is not clear whether transferrin is also able to inhibit Aβ self-association through direct binding of Aβ. Here, using saturation transfer and off-resonance relaxation NMR spectroscopy, we show that transferrin inhibits Aβ aggregation also by preferentially binding Aβ oligomers and outcompeting Aβ monomers that would otherwise cause the growth of the Aβ oligomers into larger assemblies. This inhibitory mechanism is different from the iron-sequestration model, but it is qualitatively similar to a mechanism previously proposed for the inhibition of Aβ self-association by another plasma and cerebrospinal fluid protein, i.e., human serum albumin. These results suggest that Aβ monomer competition through direct Aβ oligomer binding might be a general strategy adopted by proteins in plasma and cerebrospinal fluid to prevent Aβ aggregation. Copyright © 2013 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  14. [Insomnia associated with psychiatric disorders].

    Science.gov (United States)

    Suzuki, Masahiro; Konno, Chisato; Furihata, Ryuji; Osaki, Koichi; Uchiyama, Makoto

    2009-08-01

    Most psychiatric disorders, such as schizophrenia, mood disorders, or neurotic disorders are associated with sleep disorders of various kinds, among which insomnia is most prevalent and important in psychiatric practice. Almost all patients suffering from major depression complain of insomnia. Pharmacological treatment of insomnia associated with major depression shortens the duration to achieve remission of depression. Insomnia has been recently reported to be a risk factor for depression. In patients with schizophrenia, insomnia is often an early indicator of the aggravation of psychotic symptoms. Electroencephalographic sleep studies have also revealed sleep abnormalities characteristic to mood disorders, schizophrenia and anxiety disorders. A shortened REM sleep latency has been regarded as a biological marker of depression. Reduced amount of deep non-REM sleep has been reported to be correlated with negative symptoms of schizophrenia. Recently, REM sleep abnormalities were found in teenagers having post-traumatic stress disorder after a boat accident. Although these facts indicate that insomnia plays an important role in the development of psychiatric disorders, there are few hypotheses explaining the cause and effect of insomnia in these disorders. Here, we reviewed recent articles on insomnia associated with psychiatric disorders together with their clinical managements.

  15. Why join the Staff Association

    CERN Multimedia

    Association du personnel

    2011-01-01

    Becoming a member of the Staff Association (SA) is above all a personal choice, showing that the joining person’s commitment and adherence to values such as solidarity, social cohesion, etc.In September, the SA launches a membership campaign to convince a maximum number to join, to inform, arouse interest and support. Posters, emails and individual contacts are part of the campaign programme, just like this editorial. As far as individual contacts are concerned, we ask you to give time and lend an ear to the delegates of your department in the Staff Council, who will approach you, in order to make an open and constructive discussion possible. Do not hesitate to ask questions and let them know your thoughts about the SA, as (constructive) criticism enables us to progress. The Staff Association and its role of collective representation The Staff Association, via its delegates, represents collectively all staff of the Organization before the Director-General and Member States. To do this, staff rep...

  16. 25 CFR 700.722 - Grazing associations.

    Science.gov (United States)

    2010-04-01

    ... associations will provide the means for the members: (1) To jointly manage their permitted livestock and the... constitution and bylaws. All of the association's livestock will be run under an association brand properly...

  17. Pathogenesis of PR3-ANCA associated vasculitis

    NARCIS (Netherlands)

    Kallenberg, C. G. M.

    2008-01-01

    Wegener's Granulomatosis (WG) is closely associated with antineutrophil cytoplasmic autoantibodies (ANCA), particularly those directed to proteinase 3 (PR3). ANCA directed to myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and the Churg Strauss syndrome. PR3-ANCA associated

  18. A PROPOSAL OF FUZZY MULTIDIMENSIONAL ASSOCIATION RULES

    Directory of Open Access Journals (Sweden)

    Rolly Intan

    2006-01-01

    Full Text Available Association rules that involve two or more dimensions or predicates can be referred as multidimensional association rules. Rather than searching for frequent itemsets (as is done in mining single-dimensional association rules, in multidimensional association rules, we search for frequent predicate sets. In general, there are two types of multidimensional association rules, namely interdimension association rules and hybrid-dimension association rules. Interdimension association rules are multidimensional association rules with no repeated predicates. This paper introduces a method for generating interdimension association rules. A more meaningful association rules can be provided by generalizing crisp value of attributes to be fuzzy value. To generate the multidimensional association rules implying fuzzy value, this paper introduces an alternative method for mining the rules by searching for the predicate sets.

  19. Vaginosis-associated bacteria and its association with HPV infection.

    Science.gov (United States)

    Romero-Morelos, Pablo; Bandala, Cindy; Jiménez-Tenorio, Julián; Valdespino-Zavala, Mariana; Rodríguez-Esquivel, Miriam; Gama-Ríos, Reyna Anaid; Bandera, Artfy; Mendoza-Rodríguez, Mónica; Taniguchi, Keiko; Marrero-Rodríguez, Daniel; López-Romero, Ricardo; Ramón-Gallegos, Eva; Salcedo, Mauricio

    2018-03-12

    Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history. All samples were screened for Atopobium vaginae, Gardnerella vaginalis and HPV by PCR. High HPV prevalence was found in precursor samples, and 30% of samples without lesions were positive for HPV. Virtually all samples contained sequences of both bacteria, and interestingly, there was not HPV association observed; these results could suggest that these microorganisms could be part of the cervical microbiome in Mexican population. The results obtained indicate that the bacteria analysed could be part of normal biome in Mexican women, suggesting a potential reconsideration of the pathogen role of these microorganisms. Copyright © 2018 Elsevier España, S.L.U. All rights reserved.

  20. Mucosal melanosis associated with chemoembolization

    Directory of Open Access Journals (Sweden)

    Ali Alkan

    2015-06-01

    Full Text Available Mucosal lesions due to underlying disease or drug toxicity, are important part of oncology practice. Patient with a diagnosis of hepatocellular carcinoma was treated with chemoembolisation. She presented with new onset of mucosal hyperpigmented lesion all through her oral cavity. Biopsy was consistent with mucosal melanosis, which was associated with the chemotherapeutics used in the chemoembolisation procedure. Lesion progressively improved without any treatment. Here we present an mucosal melanosis experience after chemoembolisation. J Clin Exp Invest 2015; 6 (2: 189-191

  1. The Bayesian Approach to Association

    Science.gov (United States)

    Arora, N. S.

    2017-12-01

    The Bayesian approach to Association focuses mainly on quantifying the physics of the domain. In the case of seismic association for instance let X be the set of all significant events (above some threshold) and their attributes, such as location, time, and magnitude, Y1 be the set of detections that are caused by significant events and their attributes such as seismic phase, arrival time, amplitude etc., Y2 be the set of detections that are not caused by significant events, and finally Y be the set of observed detections We would now define the joint distribution P(X, Y1, Y2, Y) = P(X) P(Y1 | X) P(Y2) I(Y = Y1 + Y2) ; where the last term simply states that Y1 and Y2 are a partitioning of Y. Given the above joint distribution the inference problem is simply to find the X, Y1, and Y2 that maximizes posterior probability P(X, Y1, Y2| Y) which reduces to maximizing P(X) P(Y1 | X) P(Y2) I(Y = Y1 + Y2). In this expression P(X) captures our prior belief about event locations. P(Y1 | X) captures notions of travel time, residual error distributions as well as detection and mis-detection probabilities. While P(Y2) captures the false detection rate of our seismic network. The elegance of this approach is that all of the assumptions are stated clearly in the model for P(X), P(Y1|X) and P(Y2). The implementation of the inference is merely a by-product of this model. In contrast some of the other methods such as GA hide a number of assumptions in the implementation details of the inference - such as the so called "driver cells." The other important aspect of this approach is that all seismic knowledge including knowledge from other domains such as infrasound and hydroacoustic can be included in the same model. So, we don't need to separately account for misdetections or merge seismic and infrasound events as a separate step. Finally, it should be noted that the objective of automatic association is to simplify the job of humans who are publishing seismic bulletins based on this

  2. Associative programming language and virtual associative access manager

    Science.gov (United States)

    Price, C.

    1978-01-01

    APL provides convenient associative data manipulation functions in a high level language. Six statements were added to PL/1 via a preprocessor: CREATE, INSERT, FIND, FOR EACH, REMOVE, and DELETE. They allow complete control of all data base operations. During execution, data base management programs perform the functions required to support the APL language. VAAM is the data base management system designed to support the APL language. APL/VAAM is used by CADANCE, an interactive graphic computer system. VAAM is designed to support heavily referenced files. Virtual memory files, which utilize the paging mechanism of the operating system, are used. VAAM supports a full network data structure. The two basic blocks in a VAAM file are entities and sets. Entities are the basic information element and correspond to PL/1 based structures defined by the user. Sets contain the relationship information and are implemented as arrays.

  3. [Acute pancreatitis associated with hypercalcaemia].

    Science.gov (United States)

    Tun-Abraham, Mauro Enrique; Obregón-Guerrero, Gabriela; Romero-Espinoza, Larry; Valencia-Jiménez, Javier

    2015-01-01

    Hypercalcaemia due to primary hyperparathyroidism is a rare cause of acute pancreatitis, with a reported prevalence of 1.5 to 8%. There is no clear pathophysiological basis, but elevated parathyroid hormone and high serum calcium levels could be responsible for calcium deposit in the pancreatic ducts and activation of pancreatic enzymes, which may be the main risk factor for developing acute pancreatitis. The aim of this report is to describe four cases. Four cases are reported of severe pancreatitis associated with hypercalcaemia secondary to primary hyperparathyroidism; three of them with complications (two pseudocysts and one pancreatic necrosis). Cervical ultrasound, computed tomography, and scintigraphy using 99mTc-Sestambi, studies showed the parathyroid adenoma. Surgical resection was the definitive treatment in all four cases. None of the patients had recurrent acute pancreatitis events during follow-up. Acute pancreatitis secondary to hypercalcaemia of primary hyperparathyroidism is rare; however, when it occurs it is associated with severe pancreatitis. It is suspected in patients with elevated serum calcium and high parathyroid hormone levels. Imaging techniques such as cervical ultrasound, computed tomography, and scintigraphy using 99mTc-Sestambi, should be performed, to confirm clinical suspicion. Surgical resection is the definitive treatment with excellent results. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

  4. Association between Frailty and Dementia

    DEFF Research Database (Denmark)

    Kulmala, J; Nykänen, I; Mänty, Minna Regina

    2014-01-01

    Background: Frailty is commonly considered as a syndrome with several symptoms, including weight loss, exhaustion, weakness, slow walking speed and physical inactivity. It has been suggested that cognitive impairment should be included in the frailty index, however the association between frailty...... dementia with Lewy bodies and 8 persons (1%) had some other type of dementia. Multivariate logistic regression models showed that frail persons were almost 8 times more likely to have cognitive impairment (OR 7.8, 95% CI 4.0-15.0), 8 times more likely to have some kind of dementia (OR 8.0, 95% CI 4.......0-15.9), almost 6 times more likely to have vascular dementia (OR 5.6, 95% CI 1.2-25.8) and over 4 times more likely to have Alzheimer's disease (OR 4.5, 95% CI 2.1-9.6) than persons who were robust. Conclusion: Frailty is strongly associated with cognitive impairment and clinically diagnosed dementia among...

  5. Factors associated with secondary infertility

    Directory of Open Access Journals (Sweden)

    Hasina Momtaz

    2011-01-01

    Full Text Available Infertility is an experience that strikes at the very core of a woman’s life and as a whole her family and society. Studies in Bangladesh to evaluate the factors are difficult to come by. This case control study was carried out from Jan 2010 to June 2010 to find out the factors associated with secondary infertility. A total of 70 cases were selected from the infertility unit of Bangabandhu Sheikh Mujib Medical University and 70 unmatched controls from the same hospital attending the pediatrics unit with their children were also recruited. Data were collected by interview and review of documents. No age difference was noticed between the cases (29.26 ± 4.13 and controls (29.21 ± 3.95. Association of secondary infertility was found with body mass index (p=0.036, previous bad obstetric history (p = 0.011 and previous caesarian delivery (p=0.044. Women with secondary infertility were more than four times more likely to have gynecological problem(s than their fertile counterparts [OR 4.76 with 95% CI (2.018-11.270]. The factors identified in this study might help the policy makers in designing prevention and health care programmes and thus reducing the hidden burden of secondary infertility. Ibrahim Med. Coll. J. 2011; 5(1: 17-21

  6. Covariance Association Test (CVAT) Identifies Genetic Markers Associated with Schizophrenia in Functionally Associated Biological Processes

    DEFF Research Database (Denmark)

    Rohde, Palle Duun; Demontis, Ditte; Castro Dias Cuyabano, Beatriz

    2016-01-01

    power to detect genetic markers with small effects. Instead, aggregating genetic markers based on biological information might increase the power to identify sets of genetic markers of etiological significance. Several set test methods have been proposed: Here we propose a new set test derived from......Schizophrenia is a psychiatric disorder with large personal and social costs, and understanding the genetic etiology is important. Such knowledge can be obtained by testing the association between a disease phenotype and individual genetic markers; however, such single-marker methods have limited...

  7. Epidemiology of ANCA associated vasculitis

    Directory of Open Access Journals (Sweden)

    Wenche Koldingsnes

    2009-10-01

    Full Text Available ANCA associated vasculitis (AAV comprises three syndromes with systemic vasculitis (Wegener’s granulomatosis (WG, Churg Strauss syndrome (CSS and icroscopic polyangiitis (MPA, which all involve small and medium sized vessels and are associated with antibodies against cytoplasmatic antibodies in neutrophils (ANCA. Polyarteritis nodosa (PAN is included in this review as it also affects medium sized vessels, and has many clinical findings in common with the AAV.Since the recognition of ANCA, increasing data have become available on the epidemiology of these vasculitidis. WG constitutes half of the AAV and its prevalence has increased from 30/million in the late 1980’s in the USA to 160/million in this century in northern Europe. The prevalence for the whole group of primary systemic vasculitides is now 300/million in Sweden. The annual incidence of WG increased from 6.0/million to 14/million during the 1990’s in Tromsø, but it is unknown if this is a true increase or the result of an increased awareness of the diagnosis. For the whole group of AAV, the annual incidence in most more recent studies is relatively constant over time and by geographical location, ranging from 13 to 21/million. Nonetheless there are interesting differences in the prevalence of specific vasculitis between different geographical areas, as well as for sub specificities of ANCA.There seems to be a South-North gradient for WG and PR3-ANCA with high figures reported from northern Europe and southern New Zealand. In European studies WG is 90% PR3-ANCA positive. MPA which is predominantly MPO-ANCA associated are more frequent in the Mediterranean countries and also has an increasing gradient towards east-Asia, as almost all AAV in China and Japan are diagnosed as MPA, predominantly MPO-ANCA positive.There are also some ethnic and gender differences. WG is most prevalent among Caucasians in the USA and in people with European ancestors in Paris and in New Zealand, less

  8. Community-associated Staphylococcus aureus infections: pneumonia

    OpenAIRE

    Marios Karvouniaris; Demosthenes Makris; Epaminondas Zakynthinos

    2010-01-01

    Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging health problem with distinct epidemiology. CA-MRSA colonization and infection is associated with risk factors different from healthcare-associated methicillin-resistant S. aureus infection. CA-MRSA strains pre­sent different characteristics to healthcare associated strains in terms of microbiology as well. Moreover, infection as a result of CA-MRSA may be associated with severe infections, in particular ...

  9. Antisperm antibodies and fertility association.

    Science.gov (United States)

    Restrepo, B; Cardona-Maya, W

    2013-10-01

    To evaluate the relation between antisperm antibodies (ASA) and human fertility by reviewing the scientific literature of the last 45 years. We carried out a review of scientific literature about antisperm antibodies and infertility published in spanish or english in databases as Pubmed, Medline, Scielo, some books and another gray literature include information related to this review and that is published in the last 45 years. Infertile couples suffer infertility by immunological mechanisms mainly by the presence of antisperm antibodies ASA in blood, semen or cervicovaginal secretions; the formation of ASA in men and women may be associated with disturbance in immunomodulatory mechanisms that result in functional impairment of sperm and thus its inability to fertilize the oocyte. Immunological infertility caused by ASA is the result of interference of these antibodies in various stages of fertilization process, inhibiting the ability of interaction between sperm and oocyte. Copyright © 2012 AEU. Published by Elsevier Espana. All rights reserved.

  10. Is Episcleritis Associated to Glaucoma?

    Science.gov (United States)

    Pikkel, Joseph; Chassid, Otzem; Srour, Ward; Busool, Yumna; Vainer, Larisa; Epstein, Irena; Beiran, Itzchak

    2015-12-01

    The aim of this study was to show possible connection between episcleritis and open-angle glaucoma. This was a retrospective study. Data on 21 patients who suffered from episcleritis and had no previous attack of episcleritis or glaucoma were collected for a period of 8 years (from 2004 to 2011). Six of the 21 patients of the study group (28.6%) were diagnosed as suffering from glaucoma. Four patients had a diffuse conjunctival congestion, 1 had sectoral congestion, and for 1 patient there was no record of conjunctival congestion. Two of the 6 patients with episcleritis and glaucoma experienced recurrent episcleritis events during the follow-up period. This study suggests an association between episcleritis and open-angle glaucoma.

  11. Achondroplasia Associated with Bilateral Keratoconus

    Directory of Open Access Journals (Sweden)

    Ammar M. Al Mahmood

    2012-01-01

    Full Text Available We report a rare case of bilateral keratoconus in association with achondroplasia. A 26-year-old male, with a known case of achondroplasia, complained of bilateral gradual deterioration in vision for the past few years. Slit lamp biomicroscopy showed bilateral central corneal protrusion and stromal thinning at the apex consistent with keratoconus. a trial of hard contact lens fitting failed to improve VA in the left eye (LE. Right eye (RE improved to 20/25. The patient underwent penetrating keratoplasty (PKP in his LE. Twenty-seven months postoperatively, uncorrected visual acuity (UCVA was 20/30. Ophthalmologists should be aware that patients with achondroplasia who complain of poor vision should be suspected of having keratoconus once other more common conditions are ruled out.

  12. L’Association au collectif

    Directory of Open Access Journals (Sweden)

    Denis Saint-Amand

    2011-12-01

    Full Text Available À la difficulté intrinsèque que pose l’exercice du compte rendu d’un volume collectif se lie ici le fait que le groupe de recherche Acme, dont les membres rassemblent leurs énergies autour de la question de la bande dessinée et auquel on doit le recueil L’Association. Une utopie éditoriale et esthétique, est constitué en majeure partie de chercheurs en sciences humaines de l’Université de Liège ; soit des collègues avec lesquels je partage une même affiliation institutionnelle. J’ai pour auta...

  13. Clozapine-associated extrapyramidal reaction.

    Science.gov (United States)

    Elliott, E S; Marken, P A; Ruehter, V L

    2000-05-01

    To report a case of extrapyramidal reaction associated with a dosage increase of clozapine. A 44-year-old white man with a 20-year history of chronic paranoid schizophrenia was admitted to an inpatient psychiatric facility. His prior medications restarted on admission were clozapine 650 mg at bedtime, haloperidol 10 mg at bedtime, clonazepam 2 mg/d, and aspirin 325 mg/d. Two days after admission (hospital day 3), clozapine and clonazepam were discontinued, and he was prescribed haloperidol 5 mg every morning and 10 mg every evening. Stabilization occurred over the following 24 days, with progressively lower dosages of haloperidol and increasing dosages of clozapine. Haloperidol was discontinued on day 24. On day 47, the patient was agitated and making bizarre statements; thus, the morning dose of clozapine was increased by 50 mg (total 450 mg/d). On day 48 at 2200, a dystonic reaction was diagnosed; he received intramuscular diphenhydramine 50 mg, which caused the reaction to subside. At the time of the adverse reaction, he was prescribed clozapine 450 mg/d, vitamin E 400 IU three times daily, aspirin 325 mg/d, and acetaminophen, milk of magnesia, and Maalox as needed. Although the risk of extrapyramidal symptoms (EPS) is significantly lower with clozapine than with conventional agents, elevated clozapine blood concentrations have been reported to cause EPS; other reports have cited severe dystonias and dyskinesias on abrupt clozapine withdrawal. Considering the medications prescribed at the time and the discontinuation of haloperidol 24 days before the event, clozapine was the most likely cause of the extrapyramidal reaction. Regardless of anticipated safety associated with novel antipsychotics such as clozapine, reports of dystonic reactions must be taken into account and patients monitored appropriately.

  14. Thyroid Hemiagenesis Associated with Hyperthyroidism

    Directory of Open Access Journals (Sweden)

    Gunay Gurleyik

    2015-01-01

    Full Text Available Thyroid hemiagenesis (TH, very rare congenital anomaly, is generally asymptomatic. We report two cases of TH with hyperthyroidism. Case One. The patient presented with signs and symptoms of thyrotoxicosis. Physical examination revealed asymmetric nodular goitre at right lobe. Biochemical analysis revealed the diagnosis of hyperthyroidism. Ultrasound showed multinodular hypertrophy in the right lobe and absence of the left lobe. Nuclear scan, confirming absence of the left lobe, showed hot nodules in the right one. The diagnosis was toxic multinodular goitre. Case Two. The thyroid was not palpable in this patient presented with signs and symptoms of thyrotoxicosis. Biochemical analysis revealed the diagnosis of autoimmune thyrotoxicosis. Ultrasound showed mild diffuse hyperplasia of the right lobe and agenesis of the left lobe. Nuclear scan, confirming absence of the left lobe, showed increasing diffuse uptake of radiotracer in the right one. The diagnosis was Graves’ disease in this patient. After antithyroid medication, the patients were surgically treated with total excision of the thyroid tissue. TH is sometimes associated with disorders of the thyroid. Hyperthyroidism makes TH cases symptomatic. During evaluation of patients, ultrasound and nuclear scan usually report agenesis of one lobe and establish the diagnosis of TH. The surgical treatment is total removal of hyperactive tissue and total excision of the remaining lobe.

  15. Thanks to outgoing Associate Editors

    Science.gov (United States)

    Lichti, Derek D.; Weng, Qihao

    2018-04-01

    As of the end of December 2017, Professors Eberhard Gülch, Olaf Hellwich, Minho Kim, and Lalit Kumar have retired as Associate Editors of the ISPRS Journal of Photogrammetry and Remote Sensing. Our Journal's readership has benefited greatly from their longstanding commitment to their editorial duties. Both Profs. Gülch and Hellwich began their service to the Journal in 2007, while Profs. Kumar and Kim began in 2012 and 2014, respectively. In their many years as editors, they have witnessed the incredible growth of the Journal in terms of the number of papers submitted and published as well as the impact factor. Thanks to their high standards for paper quality and rigorous peer review, these professors have been important contributors to the Journal's current high standing. They were very versatile in terms of the scope of papers they could handle. Eberhard handled papers in photogrammetry, terrain modelling and geographic information systems (GIS) while Olaf handled papers in radar, computer vision and GIS. Both Lalit and Minho handled papers in optical remote sensing. On behalf of the Journal and the International Society for Photogrammetry and Remote Sensing, we thank them for many years of dedicated service to the Journal.

  16. Celiac disease and associated diseases

    Directory of Open Access Journals (Sweden)

    I. N. Zakharova

    2014-01-01

    Full Text Available In accordance with the current definition proposed by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN in 2012, celiac disease is regarded as an immune-mediated systemic disease caused by gluten and respective prola-mins in genetically predisposed people. Detailed studies of the pathogenesis of gluten enteropathy provided the basis for investigating the possible causes of the common concurrence of celiac disease with a number of autoimmune and endocrine diseases. The possible reasons for the association are considered to be common genetic markers in the patients, a cross reaction of the autoantibodies formed in celiac disease and activated T lymphocytes with the body's intrinsic antigens, as well as the systemic action of proinflam-matory cytokines. Although many issues of pathophysiology remain a matter of debate, the fact that patients suffering from a number of diseases form a group at risk for celiac disease and require a careful follow-up and examination for timely diagnosis and use of gluten-free diet is currently beyond question.

  17. [Isaacs's syndrome and associated diseases].

    Science.gov (United States)

    Watanabe, Osamu

    2013-01-01

    Isaacs' syndrome is an antibody-mediated potassium channel disorder. Clinical symptoms of Isaacs' syndrome are characterized by muscle cramp, slow relaxation following muscle contraction, and hyperhidrosis. Hyperexcitability of the peripheral nerve cause these symptoms, which are relieved by administration of Na channel blockers and immunotherapy.The target channel proteins are voltage-gated potassium channels (VGKCs). The suppression of voltage-gated outward K(+) current by antibodies induces hyperexcitability of the peripheral nerve. Electrophysiological findings show that antibodies may not directly block the kinetics of VGKCs, but may decrease channel density. From the electrophysiological, pharmacologic and immunologic view points, the site of origin of spontaneous discharges is located principally in the distal portion of the motor nerve."VGKC antibodies" are also detected in Morvan syndrome (severe insomnia with neuromyotonia and various autonomic disorders) and in a form of autoimmune limbic encephalitis. Recent studies indicated that the "VGKC antibodies" are mainly directed toward associated proteins (for example LGI-1, CASPR-2) that complex with VGKCs themselves. The "VGKC antibodies" are now usually known as VGKC-complex antibodies. In general, LGI-1 antibodies are most common in limbic encephalitis with SIADH. CASPR-2 antibodies are present in the majority of patients with Morvan syndrome.

  18. Exercise-Associated Muscle Cramps

    Science.gov (United States)

    Miller, Kevin C.; Stone, Marcus S.; Huxel, Kellie C.; Edwards, Jeffrey E.

    2010-01-01

    Context: Exercise-associated muscle cramps (EAMC) are a common condition experienced by recreational and competitive athletes. Despite their commonality and prevalence, their cause remains unknown. Theories for the cause of EAMC are primarily based on anecdotal and observational studies rather than sound experimental evidence. Without a clear cause, treatments and prevention strategies for EAMC are often unsuccessful. Evidence Acquisition: A search of Medline (EBSCO), SPORTDiscus, and Silverplatter (CINHAL) was undertaken for journal articles written in English between the years 1955 and 2008. Additional references were collected by a careful analysis of the citations of others’ research and textbooks. Results: Dehydration/electrolyte and neuromuscular causes are the most widely discussed theories for the cause of EAMC; however, strong experimental evidence for either theory is lacking. Conclusions: EAMC are likely due to several factors coalescing to cause EAMC. The variety of treatments and prevention strategies for EAMC are evidence of the uncertainty in their cause. Acute EAMC treatment should focus on moderate static stretching of the affected muscle followed by a proper medical history to determine any predisposing conditions that may have triggered the onset of EAMC. Based on physical findings, prevention programs should be implemented to include fluid and electrolyte balance strategies and/or neuromuscular training. PMID:23015948

  19. Parvovirus B19 Associated Hepatitis

    Science.gov (United States)

    Bihari, Chhagan; Rastogi, Archana; Saxena, Priyanka; Rangegowda, Devraj; Chowdhury, Ashok; Gupta, Nalini; Sarin, Shiv Kumar

    2013-01-01

    Parvovirus B19 infection can present with myriads of clinical diseases and syndromes; liver manifestations and hepatitis are examples of them. Parvovirus B19 hepatitis associated aplastic anemia and its coinfection with other hepatotropic viruses are relatively underrecognized, and there is sufficient evidence in the literature suggesting that B19 infections can cause a spectrum of liver diseases from elevation of transaminases to acute hepatitis to fulminant liver failure and even chronic hepatitis. It can also cause fatal macrophage activation syndrome and fibrosing cholestatic hepatitis. Parvovirus B19 is an erythrovirus that can only be replicate in pronormoblasts and hepatocytes, and other cells which have globosides and glycosphingolipids in their membrane can also be affected by direct virus injury due to nonstructural protein 1 persistence and indirectly by immune mediated injury. The virus infection is suspected in bone marrow aspiration in cases with sudden drop of hemoglobin and onset of transient aplastic anemia in immunosuppressed or immunocompetent patients and is confirmed either by IgM and IgG positive serology, PCR analysis, and in situ hybridization in biopsy specimens or by application of both. There is no specific treatment for parvovirus B19 related liver diseases, but triple therapy regimen may be effective consisting of immunoglobulin, dehydrohydrocortisone, and cyclosporine. PMID:24232179

  20. Fusion Power Associates annual meeting

    International Nuclear Information System (INIS)

    Nickerson, S.B.

    1985-03-01

    The Fusion Power Associates symposium, 'The Search for Attractive Fusion Concepts', was held January 31 - February 1 1985 in La Jolla, California. The purpose of this meeting was to bring together industry, university and government managers of the US fusion program to discuss the state of fusion development and the direction in which the program should be heading, given the cutbacks in the US fusion budget. There was a strong, minority opinion that until the best concept could be identified, the program should be broadly based. But there was also widespread criticism, aimed mainly at the largest segment of the magnetic fusion program, the tokamak. It was felt by many that the tokamak would not develop into a reactor that would be attractive to a utility and therefore should be phased out of the program. If the tokamak will indeed not lead to a commercial product then this meeting shows the US fusion program to be in a healthy state, despite the declining budgets

  1. Nelarabine Associated Myotoxicity and Rhabdomyolysis

    Directory of Open Access Journals (Sweden)

    Mahnur Haider

    2015-01-01

    Full Text Available Nelarabine (ara-G; Arranon; compound 506U78 is an antineoplastic purine analog used for the treatment of refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL and T-cell lymphoblastic lymphoma (T-LBL. The drug was granted accelerated approval in October 2005 by the US Food and Drug Administration (FDA given the efficacy (induction of complete responses noted in 2 single-arm trials (one in pediatric setting and one in adult patient population. The main spectra of toxicities that have been reported in these clinical trials and subsequent studies are hematological and neurological. Nelarabine induced rhabdomyolysis and increased creatinine phosphokinase (CK; CPK levels apparently have been reported and this side effect has been added as an adverse reaction in the product monograph from the drug company during postmarketing surveillance. However, the true extent and incidence of the myotoxicity from the drug are unclear. In this paper we report a grade IV CK elevation and rhabdomyolysis in a patient with T-ALL treated with nelarabine. Given the reported finding, we examined the literature further for myotoxicity, increased CK, and/or rhabdomyolysis associated with the use of the nelarabine and report our findings.

  2. Discoid Meniscus Associated With Achondroplasia.

    Science.gov (United States)

    Hoernschemeyer, Daniel G; Atanda, Alfred; Dean-Davis, Ellen; Gupta, Sumit K

    2016-05-01

    Achondroplasia is the most common skeletal dysplasia. This form of dwarfism is caused by a point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene, leading to inhibition of endochondral ossification for these patients. This results in a normal trunk height but shortened limbs. The discoid meniscus may be an important associated finding to better understand the common complaints of leg pain for these patients. Although the incidence for a discoid meniscus is between 3% and 5% for the general population, it is unknown with achondroplasia. This case series includes 4 patients, with ages ranging from adolescence to early adulthood, with symptoms of knee pain that were not attributable to some of the more common findings seen in this patient population. Typically, patients with achondroplasia who experience knee pain are evaluated for more common and well-known etiologies such as genu varum, ligamentous instability, and neurogenic claudication. However, the authors propose that symptomatic discoid lateral meniscus should be added to the differential diagnosis for lower-extremity pain in the achondroplasia population. A thorough history and physical examination, in combination with magnetic resonance imaging, can aid in making the diagnosis. Treatment with arthroscopic debridement, saucerization of the meniscus, and repair for unstable injuries has yielded good outcomes for this patient population. [Orthopedics. 2016; 39(3):e498-e503.]. Copyright 2016, SLACK Incorporated.

  3. Ketamine-snorting associated cystitis

    Directory of Open Access Journals (Sweden)

    Chung-Hsien Chen

    2011-12-01

    Full Text Available Ketamine hydrochloride, commonly used as a pediatric anesthetic agent, is an N-methyl-d-aspartic (NMDA acid receptor antagonist with rapid onset and short duration of action. It produces a cataleptic-like state where the patient is dissociated from the surrounding environment by direct action on the cortex and limbic system. It has emerged as an increasingly popular choice among young drug users, especially within dance club venues. Cases of bladder dysfunction among recreational ketamine users were reported since Shahani et al first reported nine cases of ketamine-associated ulcerative cystitis in 2007. We report on four patients who had history of ketamine abuse, presenting with dysuria, fluctuating lower urinary tract symptoms (LUTS, lower abdominal or perineal pain, and impaired functional bladder capacities. Urinalysis showed pyuria and microhematuria. Urine culture was sterile. Bladder ulceration with severe diffuse hemorrhage and low bladder capacity were noted under anesthetized cystoscopic examination. Transurethral bladder mucosa biopsy was consistent with chronic cystitis. Cessation of ketamine abuse was the milestone of treatment, followed by the administration of mucosal protective agents, such as pentosan polysulphate or hyaluronic acid. Suprapubic pain was improved in three patients during follow-up. However, the outcome of treatment depends on the severity of the disease process, similar to that of interstitial cystitis (IC.

  4. Association of eumycetoma and schistosomiasis.

    Directory of Open Access Journals (Sweden)

    Jaap J van Hellemond

    Full Text Available Eumycetoma is a morbid chronic granulomatous subcutaneous fungal disease. Despite high environmental exposure to this fungus in certain regions of the world, only few develop eumycetoma for yet unknown reasons. Animal studies suggest that co-infections skewing the immune system to a Th2-type response enhance eumycetoma susceptibility. Since chronic schistosomiasis results in a strong Th2-type response and since endemic areas for eumycetoma and schistosomiasis do regionally overlap, we performed a serological case-control study to identify an association between eumycetoma and schistosomiasis. Compared to endemic controls, eumycetoma patients were significantly more often sero-positive for schistosomiasis (p = 0.03; odds ratio 3.2, 95% CI 1.18-8.46, but not for toxoplasmosis, an infection inducing a Th1-type response (p = 0.6; odds ratio 1.5, 95% CI 0.58-3.83. Here, we show that schistosomiasis is correlated to susceptibility for a fungal disease for the first time.

  5. Pregnancy-associated severe sepsis.

    Science.gov (United States)

    Oud, Lavi

    2016-04-01

    This article examines the contemporary knowledge and uncertainties about the burden of pregnancy-associated severe sepsis (PASS), and its manifestations, management, and outcomes. There are relatively sparse data on PASS, related in part to infrequent reports and varying use of terminology and case definitions. PASS remains rare, although its incidence appears to be rapidly rising in some high-resource countries, affecting especially women with limited resources, minorities, and those with chronic illness. High level of clinician vigilance and rapid initiation of appropriate antimicrobial therapy, coupled with effective systemic support for organ dysfunction and correction of occult and overt hypoperfusion are the keys to limit adverse outcomes. However, timely diagnosis and provision of effective care remain a challenge, with reported prevalent delay in recognition and delivery of time-sensitive care interventions among maternal decedents. The mortality rate of PASS has been rising and its case fatality, although relatively low, has remained unchanged, in contrast to the outcome gains in the general population. The long-term sequelae of PASS remain unknown. The relatively limited contemporary data on PASS suggest a rising public health hazard in the obstetric population in high-resource countries, with ongoing challenges in assuring consistent provision of time-sensitive care.

  6. Bacterial biofilm and associated infections

    Directory of Open Access Journals (Sweden)

    Muhsin Jamal

    2018-01-01

    Full Text Available Microscopic entities, microorganisms that drastically affect human health need to be thoroughly investigated. A biofilm is an architectural colony of microorganisms, within a matrix of extracellular polymeric substance that they produce. Biofilm contains microbial cells adherent to one-another and to a static surface (living or non-living. Bacterial biofilms are usually pathogenic in nature and can cause nosocomial infections. The National Institutes of Health (NIH revealed that among all microbial and chronic infections, 65% and 80%, respectively, are associated with biofilm formation. The process of biofilm formation consists of many steps, starting with attachment to a living or non-living surface that will lead to formation of micro-colony, giving rise to three-dimensional structures and ending up, after maturation, with detachment. During formation of biofilm several species of bacteria communicate with one another, employing quorum sensing. In general, bacterial biofilms show resistance against human immune system, as well as against antibiotics. Health related concerns speak loud due to the biofilm potential to cause diseases, utilizing both device-related and non-device-related infections. In summary, the understanding of bacterial biofilm is important to manage and/or to eradicate biofilm-related diseases. The current review is, therefore, an effort to encompass the current concepts in biofilm formation and its implications in human health and disease.

  7. Alagille Syndrome Associated with Xerophthalmia

    Directory of Open Access Journals (Sweden)

    Elad Moisseiev

    2013-12-01

    Full Text Available Purpose: To report the occurrence of xerophthalmia and keratomalacia in a patient with Alagille syndrome. Methods: The patient's record and relevant literature were reviewed. Results: A 3-year-old boy with Alagille syndrome was examined at our institution due to severe bilateral ocular irritation. A corneal ulcer and keratomalacia were found in the right eye and severe dryness with corneal opacification was found in the left eye. He was treated with topical fortified antibiotics in the right eye, followed by amniotic membrane transplantation. Due to his systemic condition, characterized by severe cholestasis and intestinal malabsorption, a suspicion of vitamin A deficiency was raised and was later confirmed in serum analysis. Conclusion: This is the first report of xerophthalmia in a patient with Alagille syndrome. Vitamin A deficiency leading to xerophthalmia is common in developing countries; however, its occurrence in the West is rare, leading to a reduced awareness of this disorder amongst clinicians. Unusual eating habits, intestinal malabsorption and liver disease are possible causes for such a deficiency. The purpose of this case report is to raise awareness to the possibility of vitamin A deficiency in children with keratopathy, especially when associated with these disorders.

  8. Sorting waves and associated eigenvalues

    Science.gov (United States)

    Carbonari, Costanza; Colombini, Marco; Solari, Luca

    2017-04-01

    The presence of mixed sediment always characterizes gravel bed rivers. Sorting processes take place during bed load transport of heterogeneous sediment mixtures. The two main elements necessary to the occurrence of sorting are the heterogeneous character of sediments and the presence of an active sediment transport. When these two key ingredients are simultaneously present, the segregation of bed material is consistently detected both in the field [7] and in laboratory [3] observations. In heterogeneous sediment transport, bed altimetric variations and sorting always coexist and both mechanisms are independently capable of driving the formation of morphological patterns. Indeed, consistent patterns of longitudinal and transverse sorting are identified almost ubiquitously. In some cases, such as bar formation [2] and channel bends [5], sorting acts as a stabilizing effect and therefore the dominant mechanism driving pattern formation is associated with bed altimetric variations. In other cases, such as longitudinal streaks, sorting enhances system instability and can therefore be considered the prevailing mechanism. Bedload sheets, first observed by Khunle and Southard [1], represent another classic example of a morphological pattern essentially triggered by sorting, as theoretical [4] and experimental [3] results suggested. These sorting waves cause strong spatial and temporal fluctuations of bedload transport rate typical observed in gravel bed rivers. The problem of bed load transport of a sediment mixture is formulated in the framework of a 1D linear stability analysis. The base state consists of a uniform flow in an infinitely wide channel with active bed load transport. The behaviour of the eigenvalues associated with fluid motion, bed evolution and sorting processes in the space of the significant flow and sediment parameters is analysed. A comparison is attempted with the results of the theoretical analysis of Seminara Colombini and Parker [4] and Stecca

  9. Analyze of Ventilator Associated Pneumonia

    Directory of Open Access Journals (Sweden)

    Aysel Sunnetcioglu

    2014-03-01

    Full Text Available Aim: Ventilator-associated pneumonia (VAP is the infection that is an important cause of morbidity and mortality developed in patients whom the invasive mechanical ventilation (MV were performed in intensive care units (ICU. In this study, the factors of VAP developing in patients whom the mechanical ventilation of ICU performed, antibiotic susceptibility to these factors and determining the risk factors were aimed. Material and Method: Between January 2009 and March 2013, 79 cases, followed with the mechanical ventilation for at least for 48 hours and developed VAP, were retrospectively reviewed at Anesthesiology and Intensive Care Unit of Reanimation at Faculty of Medicine at Yuzuncu Yil University, performing endotracheal intubation. The cases were evaluated in terms of microorganisms, antibiotic susceptibility and risk factors. Results: The rate of our VAP speed was calculated to be 19.68 on the day of 1000 ventilator. While a single microorganism could be isolated in 81.1% of the 74 VAP cases whose the active pathogen could be isolated, two or more than two microorganisms were isolated in 18.9% of them.While 83 of the strains (90.2% were gram-negative bacteria, 7 of them (7.6% were gram-positive bacteria. Acinetobacter spp. (40.2% was most commonly isolated as a gram-negative factor, but methicillin-resistant S. aureus (4.3% was isolated as a gram-positive factor. It was determined that the isolated factors in VAP cases were significantly resistant to the broad-spectrum antibiotics. Discussion: As a result, in patients with high-risk factors for the development of VAP, early and appropriate empirical antibiotic treatment should be started according to the results of the sensitivity of the unit and for the multi-drug-resistant microorganisms with common and high mortality.

  10. Molecular films associated with LDEF

    Science.gov (United States)

    Crutcher, E. R.; Warner, K. J.

    1992-01-01

    The molecular films deposited on the surface of the Long Duration Exposure Facility (LDEF) originated from the paints and room-temperature-vulcanized (RTV) silicone materials intentionally used on the satellite and not from residual contaminants. The high silicone content of most of the films and the uniformity of the films indicates a homogenization process in the molecular deposition and suggests a chemically most favored composition for the final film. The deposition on interior surfaces and vents indicated multiple bounce trajectories or repeated deposition-reemission cycles. Exterior surface deposits indicated a significant return flux. Ultraviolet light exposure was required to fix the deposited film as is indicated by the distribution of the films on interior surfaces and the thickness of films at the vent locations. Thermal conditions at the time of exposure to ultraviolet light seems to be an important factor in the thickness of the deposit. Sunrise facing (ram direction) surfaces always had the thicker film. These were the coldest surfaces at the time of their exposure to ultraviolet light. The films have a layered structure suggesting cyclic deposition. As many as 34 distinct layers were seen in the films. The cyclic nature of the deposition and the chemical uniformity of the film one layer to the next suggest an early deposition of the films though there is evidence for the deposition of molecular films throughout the nearly six year exposure of the satellite. A final 'spray' of an organic material associated with water soluble salts occurred very late in the mission. This may have been the result of one of the shuttle dump activities.

  11. Adrenomyeloneuropathy associated with congenital cataract

    International Nuclear Information System (INIS)

    Komori, Tetsuo; Nagashima, Toshiko; Hirose, Kazuhiko; Tanabe, Hitoshi; Tsubaki, Tadao

    1988-01-01

    Two cases of adrenomyeloneuropathy (AMN) in a family and the results of their MRI study are reported. Case 1, a 24-year-old male proband, was admitted to our hospital because of gait disturbance for three years. Bilateral cataracts were pointed out at birth, which required left side lenticotomy at age four. Neurological examinations on admission revealed a marked spastic paraparesis with pathological reflexes and a mild hypesthesia in the distal part of the left leg. No abnormal findings were detected in X-ray studies on the spine and spinal cord, electromyography and nerve conduction test. Serum very long chain fatty acids (VLCFAs) levels were apparently elevated, and the serum cortisol response to ACTH was low. Case 2, a 53-year-old woman, is the mother of Case 1 having a complaint of gait disturbance since age 51. She presented a mild spastic paraparesis with localized hypesthesia in the distal part of the both legs. She also had bilateral congenital cataracts. Her serum VLCFAs analysis indicated the intermediate levels between that of AMN and the normal control. Adrenal functions were normal. Cranial MRI (TR 2,000 msec/TE 80 msec) study disclosed high signal intensity areas in bilateral internal capsules in Case 1. These findings, suggesting the pathological change of dysmyelination, seemed to be well compatible with the clinical pictures. With these clinical findings and the laboratory data, these two cases were diagnosed as AMN. In addition, association of congenital cataract with AMN in both cases was characteristic in this family, which hasn't been reported in the literature. On regarding the genetic background of these two disorders, AMN and congenital cataract, it was speculated that each gene could be closely located on the same or very adjacent locus, possibly on Xq. (author)

  12. Clinicopathological associations of acquired erythroblastopenia.

    Science.gov (United States)

    Gunes, Gursel; Malkan, Umit Yavuz; Yasar, Hatime Arzu; Eliacik, Eylem; Haznedaroglu, Ibrahim Celalettin; Demiroglu, Haluk; Sayinalp, Nilgun; Aksu, Salih; Etgul, Sezgin; Aslan, Tuncay; Goker, Hakan; Ozcebe, Osman Ilhami; Buyukasik, Yahya

    2015-01-01

    Acquired erythroblastopenia (AE) is a rare clinical situation. It is characterized by the reduction of erythroid precursors in the bone marrow together with the low reticulocyte counts in the peripheral blood. Main secondary causes of AE are drugs, Parvovirus B19 and other infectious reasons, lymphoid and myeloid neoplasia, autoimmune diseases, thymoma and pregnancy. The aim of this study is to assess the frequencies and clinical associations of AE via analyzing 12340 bone marrow samples in a retrospective manner. Bone marrow aspirations which were obtained from patients who applied to Hacettepe University Hematology Clinic between 2002 and 2013, were analyzed retrospectively. Thirty four erythroblastopenia cases were found. Patients ranged in age from 16 to 80 years with a median of 38 years. Fifteen patients were men (44%) and nineteen were women (56%). In these patients, detected causes of erythroblastopenia were MDS, idiopathic pure red cell aplasia (PRCA), parvovirus infection, post chemotherapy aplasia, plasma proliferative diseases, copper deficiency due to secondary amyloidosis, fever of unknown origin, hemophagocytic syndrome, enteric fever and legionella pneumonia. We found that between those reasons the most common causes of erythroblastopenia are MDS (17.7%) and idiopathic PRCA (17.7%). As a result, erythroblastopenia in the bone marrow may be an early sign of MDS. In those AE cases possibility of being MDS must be kept in mind as it can be mistaken for PRCA. To conclude, in adults MDS without excess blast is one of the most common causes of erythroblastopenia in clinical practice and in case of erythroblastopenia the presence of MDS should be investigated.

  13. American Association of Occupational Health Nurses

    Science.gov (United States)

    ... Online Store Workplace Health & Safety Journal Awards & Recognition Occupational Health Nurses Week Member Discounts Monthly Newsletter Foundation About ... effective January 1, 2018. The American Association of Occupational Health Nurses, Inc. is the primary association for the ...

  14. Primary Sjogren's syndrome associated with inappropriate ...

    African Journals Online (AJOL)

    A patient in whom primary Sjogren's syndrome and inappropriate antiduretic hormone secretion were associated is reported. This is the first report of such an association. The possible pathophysiological mechanisms are discussed and vasculitis proposed as the underlying pathogenetic mechanism.

  15. Characterization of melanoma associated spongiform scleropathy

    DEFF Research Database (Denmark)

    Alyahya, Ghassan Ayish Jabur; Heegaard, Steffen; Prause, J.U.

    2002-01-01

    ophthalmology, melanoma associated spongiform scleropathy (MASS), MASS, malignant uveal melanoma, sclera, ciliary body, choroid, histopathology......ophthalmology, melanoma associated spongiform scleropathy (MASS), MASS, malignant uveal melanoma, sclera, ciliary body, choroid, histopathology...

  16. Association between competing interests and authors' conclusions

    DEFF Research Database (Denmark)

    Kjaergard, Lise L; Als-Nielsen, Bodil

    2002-01-01

    To assess the association between competing interests and authors' conclusions in randomised clinical trials.......To assess the association between competing interests and authors' conclusions in randomised clinical trials....

  17. The Founding of the Learning Communities Association

    Science.gov (United States)

    Huerta, Juan Carlos

    2017-01-01

    Learning communities have reached the point in their growth that we now need a professional association to allow for more opportunities for participation in advancing learning communities. This is the story of the founding of the new Learning Communities Association.

  18. Dermatomyositis Associated with Lung Neuroendocrine Carcinoma

    Science.gov (United States)

    Takashima, Reina; Takamatsu, Kazufumi; Shinkawa, Yutaka; Yagita, Masato; Fukui, Motonari; Fujita, Masaaki

    2017-01-01

    Dermatomyositis is associated with various types of malignancy. However, the association of dermatomyositis with lung neuroendocrine carcinoma is rare. We herein report a case of dermatomyositis with lung neuroendocrine carcinoma. PMID:28321077

  19. Dermatomyositis Associated with Lung Neuroendocrine Carcinoma

    OpenAIRE

    Takashima, Reina; Takamatsu, Kazufumi; Shinkawa, Yutaka; Yagita, Masato; Fukui, Motonari; Fujita, Masaaki

    2017-01-01

    Dermatomyositis is associated with various types of malignancy. However, the association of dermatomyositis with lung neuroendocrine carcinoma is rare. We herein report a case of dermatomyositis with lung neuroendocrine carcinoma.

  20. Cardiovascular hospitalizations and associations with environmental quality

    Science.gov (United States)

    Cardiovascular disease has been identified as a condition that may be associated with environmental factors. Air pollution in particular has been demonstrated to be associated with cardiovascular disease and atherosclerosis, which can increase the likelihood of cardiovascular eve...

  1. Association of African Universities : Education and Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Association of African Universities : Education and Research Networking Unit. The Association of African Universities (AAU), headquartered in Accra, Ghana, is an international nongovernmental organization (NGO) that promotes cooperation between African universities and with the international community.

  2. 7 CFR 1000.18 - Cooperative association.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE GENERAL PROVISIONS OF FEDERAL MILK MARKETING ORDERS Definitions § 1000.18 Cooperative association. Cooperative association means any cooperative marketing...

  3. Groupoids which satisfy certain associative laws

    OpenAIRE

    Pushkashu, D. I.

    2010-01-01

    In this paper we study properties of left (right) division (cancellative) groupoids with associative-like identities, namely, with cyclic associative identity (x (y z) = (z x) y) and Tarki (x (z y) = (x y) z) identities.

  4. Associations between baseline allergens and polysensitization

    DEFF Research Database (Denmark)

    Carlsen, Berit Christina; Menné, Torkil; Johansen, Jeanne Duus

    2008-01-01

    sulfate, epoxy resin, primin, and nickel sulfate showed statistically significant negative associations to polysensitization. For the allergens with the strongest associations, only every second individual with these particular allergies had two or more additional allergies. CONCLUSIONS: No common...

  5. Should there be an Australian Army Association?

    Science.gov (United States)

    2006-12-15

    of the United States Army BAFF British Armed Forces Federation BCOF British Commonwealth Occupation Forces CAD Canadian Dollars CDA Conference of...Federation ( BAFF ) 7. The Canadian Infantry Association 23 8. The Royal Canadian Armoured Corps Association 9. The Canadian Association of Veterans in...surprising that these associations and the focus of their objects have high degrees of similarity.2 The British Armed Forces Federation ( BAFF ) is a

  6. OPATs: Omnibus P-value association tests.

    Science.gov (United States)

    Chen, Chia-Wei; Yang, Hsin-Chou

    2017-07-10

    Combining statistical significances (P-values) from a set of single-locus association tests in genome-wide association studies is a proof-of-principle method for identifying disease-associated genomic segments, functional genes and biological pathways. We review P-value combinations for genome-wide association studies and introduce an integrated analysis tool, Omnibus P-value Association Tests (OPATs), which provides popular analysis methods of P-value combinations. The software OPATs programmed in R and R graphical user interface features a user-friendly interface. In addition to analysis modules for data quality control and single-locus association tests, OPATs provides three types of set-based association test: window-, gene- and biopathway-based association tests. P-value combinations with or without threshold and rank truncation are provided. The significance of a set-based association test is evaluated by using resampling procedures. Performance of the set-based association tests in OPATs has been evaluated by simulation studies and real data analyses. These set-based association tests help boost the statistical power, alleviate the multiple-testing problem, reduce the impact of genetic heterogeneity, increase the replication efficiency of association tests and facilitate the interpretation of association signals by streamlining the testing procedures and integrating the genetic effects of multiple variants in genomic regions of biological relevance. In summary, P-value combinations facilitate the identification of marker sets associated with disease susceptibility and uncover missing heritability in association studies, thereby establishing a foundation for the genetic dissection of complex diseases and traits. OPATs provides an easy-to-use and statistically powerful analysis tool for P-value combinations. OPATs, examples, and user guide can be downloaded from http://www.stat.sinica.edu.tw/hsinchou/genetics/association/OPATs.htm. © The Author 2017

  7. 11 CFR 114.8 - Trade associations.

    Science.gov (United States)

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Trade associations. 114.8 Section 114.8 Federal Elections FEDERAL ELECTION COMMISSION GENERAL CORPORATE AND LABOR ORGANIZATION ACTIVITY § 114.8 Trade associations. (a) Definition. A trade association is generally a membership organization of persons engaging in...

  8. Associations between asthma and bronchial hyperresponsiveness ...

    African Journals Online (AJOL)

    Skinprick tests (SPTs) were performed for 8 aeroallergens and 4 food allergens. Results. Asthma was reported in 9%, and 16% demonstrated BHR. Rhinitis was reported in 48% and eczema in 19%. Asthma was strongly associated with BHR. Asthma was associated with eczema whereas BHR was associated with rhinitis.

  9. Efficient Mining of Intertransaction Association Rules

    NARCIS (Netherlands)

    Tung, A.K.H.; Lu, H.J.; Han, J.W.; Feng, L.

    Most of the previous studies on mining association rules are on mining intratransaction associations, i.e., the associations among items within the same transaction where the notion of the transaction could be the items bought by the same customer, the events happened on the same day, etc. In this

  10. Histopathology of mucosa-associated lymphoid tissue

    NARCIS (Netherlands)

    Kuper, C.F.

    2006-01-01

    Mucosa-associated lymphoid tissue (MALT) is a generalized term incorporating a disseminated collection of lymphoid tissues in multiple sites throughout the body. MALT sites that have been/are primarily studied include bronchus-associated lymphoid tissue (BALT), gut-associated lymphoid tissue (GALT),

  11. Associative and Lie deformations of Poisson algebras

    OpenAIRE

    Remm, Elisabeth

    2011-01-01

    Considering a Poisson algebra as a non associative algebra satisfying the Markl-Remm identity, we study deformations of Poisson algebras as deformations of this non associative algebra. This gives a natural interpretation of deformations which preserves the underlying associative structure and we study deformations which preserve the underlying Lie algebra.

  12. Associations of objectively and subjectively measured physical ...

    African Journals Online (AJOL)

    Accelerometer-measured moderate and vigorous habitual PA is associated with indices of cortical bone size and geometry in children, whereas light PA has no detectable association. Furthermore, the bone-specific questionnaire appears to be more strongly associated with bone outcomes than accelerometer-derived ...

  13. MYOSITIS ASSOCIATED WITH MALIGNANT TUMORS

    Directory of Open Access Journals (Sweden)

    O. A. Antelava

    2016-01-01

    Full Text Available Idiopathic inflammatory myopathies (IIM are a heterogeneous group of acquired systemic diseases mainly involving skeletal muscles. The main representatives of IIM are polymyositis (PM and dermatomyositis (DM. Epidemiological surveys demonstrate that there is a relationship between PM/DM and malignant neoplasms (MNs, the detection risk of which is higher than that in the population of respective age groups. The rate of MNs in PM/DM ranges from 9 to 50%. The relationship to MNs is described in each subtype of IIM; however, these are most common in DM. The patients suffering from PM/DM associated with MNs have a worse prognosis than those without MNs. The early detection of MNs could improve the prognosis in these patients. The investigations published identify demographic, clinical, and laboratory factors increasing MN detection risks in patients with PM/DM. Just the same, they all cover small patient groups; the findings are heterogeneous and not well convincing, which calls for a further larger-scale study of this problem.Objective: to reveal and identify the specific features of paraneoplastic myositis (PnM.Subjects and methods. The investigation included 320 patients with a valid diagnosis of IIM, who had been followed up in the period of 1996 to 2016. The patients underwent laboratory tests, manual proximal muscle strength testing using a 10-point scale and electromyographic examination with needle electrodes.Results and discussion. PnM was detected in 32 (10% of the 320 patients with IIM. Among the patients with PnM, there were 6 (19% men and 26 (81% women. The mean age at the onset of PnM was 55.4 years. PnM manifested with characteristic musculocutaneous syndrome in 19 (59% patients; 18 (41% of them were found to have MNs within the first year after disease onset. The manifestation of MNs was preliminary to the picture of PM/DM in 13 (41% patients. The most commonly detected conditions were ovarian cancer (37.5%, MNs of the lung and breast

  14. Associative learning for a robot intelligence

    CERN Document Server

    Andreae, John H

    1998-01-01

    The explanation of brain functioning in terms of the association of ideas has been popular since the 17th century. Recently, however, the process of association has been dismissed as computationally inadequate by prominent cognitive scientists. In this book, a sharper definition of the term "association" is used to revive the process by showing that associative learning can indeed be computationally powerful. Within an appropriate organization, associative learning can be embodied in a robot to realize a human-like intelligence, which sets its own goals, exhibits unique unformalizable behaviou

  15. YAGM: a web tool for mining associated genes in yeast based on diverse biological associations.

    Science.gov (United States)

    Wu, Wei-Sheng; Wang, Chung-Ching; Jhou, Meng-Jhun; Wang, Yu-Cheng

    2015-01-01

    Investigating association between genes can be used in understanding the relations of genes in biological processes. STRING and GeneMANIA are two well-known web tools which can provide a list of associated genes of a query gene based on diverse biological associations such as co-expression, co-localization, co-citation and so on. However, the transcriptional regulation association and mutant phenotype association have not been used in these two web tools. Since the comprehensive transcription factor (TF)-gene binding data, TF-gene regulation data and mutant phenotype data are available in yeast, we developed a web tool called YAGM (Yeast Associated Genes Miner) which constructed the transcriptional regulation association, mutant phenotype association and five commonly used biological associations to mine a list of associated genes of a query yeast gene. In YAGM, we collected seven kinds of datasets including TF-gene binding (TFB) data, TF-gene regulation (TFR) data, mutant phenotype (MP) data, functional annotation (FA) data, physical interaction (PI) data, genetic interaction (GI) data, and literature evidence (LE) data. Then by using the hypergeometric test to calculate the association scores of all gene pairs in yeast, we constructed seven biological associations including two transcriptional regulation associations (TFB association and TFR association), MP association, FA association, PI association, GI association, and LE association. Moreover, the expression profile association from SPELL database was also included in YAGM. When using YAGM, users can input a query gene and choose any possible subsets of the eight biological associations, then a list of associated genes of the query gene will be returned based on the chosen biological associations. In this study, we presented the YAGM which provides eight biological associations for mining associated genes of a query gene in yeast. Among the eight biological associations constructed in YAGM, three (TFB

  16. Pemphigus vulgaris-associated interstitial lung disease.

    Science.gov (United States)

    Bai, Yi-Xiu; Chu, Jin-Gang; Xiao, Ting; Chen, Hong-Duo

    2016-07-01

    Autoimmune bullous diseases (AIBDs)-associated interstitial lung disease (ILD) is extremely rare. Pemphigus vulgaris (PV) is an intraepidermal autoimmune blistering disease caused by circulating autoantibodies against desmoglein. To date, PV-associated ILD has rarely been reported in English literature. We report a rare association of PV and ILD. A 53-year-old Chinese female with PV for 8 months developed ILD after a relapse of PV for 2 months due to discontinuation of oral prednisone by herself. She was successfully treated by systemic methylprednisolone. Taken previously reported bullous pemphigoid-associated ILD and linear IgA/IgG bullous dermatosis-associated ILD together, in general, AIBDs-associated ILD occurs when AIBDs relapse or are not controlled, responds well to systemic corticosteroids, and has a relatively better prognosis when compared with rheumatoid arthritis- or dermatomyositis-associated ILD. © 2016 Wiley Periodicals, Inc.

  17. Learned reward association improves visual working memory.

    Science.gov (United States)

    Gong, Mengyuan; Li, Sheng

    2014-04-01

    Statistical regularities in the natural environment play a central role in adaptive behavior. Among other regularities, reward association is potentially the most prominent factor that influences our daily life. Recent studies have suggested that pre-established reward association yields strong influence on the spatial allocation of attention. Here we show that reward association can also improve visual working memory (VWM) performance when the reward-associated feature is task-irrelevant. We established the reward association during a visual search training session, and investigated the representation of reward-associated features in VWM by the application of a change detection task before and after the training. The results showed that the improvement in VWM was significantly greater for items in the color associated with high reward than for those in low reward-associated or nonrewarded colors. In particular, the results from control experiments demonstrate that the observed reward effect in VWM could not be sufficiently accounted for by attentional capture toward the high reward-associated item. This was further confirmed when the effect of attentional capture was minimized by presenting the items in the sample and test displays of the change detection task with the same color. The results showed significantly larger improvement in VWM performance when the items in a display were in the high reward-associated color than those in the low reward-associated or nonrewarded colors. Our findings suggest that, apart from inducing space-based attentional capture, the learned reward association could also facilitate the perceptual representation of high reward-associated items through feature-based attentional modulation.

  18. Priming in a free association task as a function of association directionality

    NARCIS (Netherlands)

    Zeelenberg, R.; Shiffrin, R.M.; Raaijmakers, J.G.W.

    1999-01-01

    Two experiments investigated priming in free association, a conceptual implicit memory task. The stimuli consisted of bidirectionally associated word pairs (e.g., BEACH-SAND) and unidirectionally associated word pairs that have no association from the target response back to the stimulus cue (e.g.,

  19. NEPHROPATHIES ASSOCIATED WITH COMPLEMENT SYSTEM PATHOLOGY

    Directory of Open Access Journals (Sweden)

    V. V. Dlin

    2016-01-01

    Full Text Available Summarized research material for nephropathy associated with the pathology of the complement system in children and adults. Presents clinical, immunological and morphological differences of the nephropathy associated with the pathology of the complement system with other renal diseases, especially glomerulonephritis, including membranoproliferative variants and nephrotic syndrome associated with disorders of complement. The pathogenesis of the development of nephropathy associated with the pathology of the complement system, where highlighted as forms, associated with genetic mutations or variants, due to the formation of autoantibodies to components of the complement. Shown the options and effectiveness of treatment immunosuppressive drugs and by eculizumab depending on pathogenetic and clinical features of nephropathy associated with the pathology of the complement system.

  20. Associations between baseline allergens and polysensitization

    DEFF Research Database (Denmark)

    Carlsen, B.C.; Menne, T.; Johansen, J.D.

    2008-01-01

    : Seven allergens - parabens mix, N-isopropyl-N-phenyl-p-phenylenediamine, sesquiterpene lactone mix, wool alcohols, potassium dichromate, Myroxylon pereirae, and cobalt chloride - showed statistically significant positive associations to polysensitization. Five allergens p-phenylenediamine, neomycin...... sulfate, epoxy resin, primin, and nickel sulfate showed statistically significant negative associations to polysensitization. For the allergens with the strongest associations, only every second individual with these particular allergies had two or more additional allergies. Conclusions: No common...

  1. Primary sclerosing cholangitis associated with systemic sclerosis.

    Science.gov (United States)

    Fraile, G.; Rodríguez-García, J. L.; Moreno, A.

    1991-01-01

    Primary sclerosing cholangitis is a chronic inflammatory fibrotic disorder strongly associated with inflammatory bowel disease. Although an association between some inflammatory fibrotic conditions, such as Riedel's thyroiditis and retroperitoneal fibrosis and primary sclerosing cholangitis has been described, to our knowledge there are no reports of primary sclerosing cholangitis in patients with systemic sclerosis. A patient with this combination of conditions is presented and the possible significance of the association discussed. Images Figure 1 Figure 2 PMID:2041852

  2. Human salmonellosis associated with exotic pets.

    OpenAIRE

    Woodward, D L; Khakhria, R; Johnson, W M

    1997-01-01

    During the period from 1994 to 1996, an increase in the number of laboratory-confirmed cases of human salmonellosis associated with exposure to exotic pets including iguanas, pet turtles, sugar gliders, and hedgehogs was observed in Canada. Pet turtle-associated salmonellosis was recognized as a serious public health problem in the 1960s and 1970s, and in February 1975 legislation banning the importation of turtles into Canada was enacted by Agriculture Canada. Reptile-associated salmonellosi...

  3. On Associative Conformal Algebras of Linear Growth

    OpenAIRE

    Retakh, Alexander

    2000-01-01

    Lie conformal algebras appear in the theory of vertex algebras. Their relation is similar to that of Lie algebras and their universal enveloping algebras. Associative conformal algebras play a role in conformal representation theory. We introduce the notions of conformal identity and unital associative conformal algebras and classify finitely generated simple unital associative conformal algebras of linear growth. These are precisely the complete algebras of conformal endomorphisms of finite ...

  4. Recovering convexity in non-associated plasticity

    Science.gov (United States)

    Francfort, Gilles A.

    2018-03-01

    We quickly review two main non-associated plasticity models, the Armstrong-Frederick model of nonlinear kinematic hardening and the Drucker-Prager cap model. Non-associativity is commonly thought to preclude any kind of variational formulation, be it in a Hencky-type (static) setting, or when considering a quasi-static evolution because non-associativity destroys convexity. We demonstrate that such an opinion is misguided: associativity (and convexity) can be restored at the expense of the introduction of state variable-dependent dissipation potentials.

  5. Associated factors to academic performance in adult

    Directory of Open Access Journals (Sweden)

    Mawency Vergel-Ortega

    2016-08-01

    Full Text Available The article has the objective identify the associated factors to academic performance of adult students in mathematics and statistics modules. Was realized a study quantitative correlational in a sample of 80 students with age over 30 years old. A group of institutional aspects, social-demographics, psychosocials and pedagogic factors were used as independent variable. Results indicate that style of learning associated with type of intelligence, deficit conscience associated to abstraction capability and family motivation predicts the higher levels of performance, constituting explicative variables. Conclusion: type and style of learning, type of intelligence, motivation, conscience of deficit are associated factors to performance in adults.

  6. Macroinvertebrates associated with two submerged macrophytes ...

    African Journals Online (AJOL)

    Macroinvertebrates associated with two submerged macrophytes, Lagarosiphon ilicifolius and Vallisneria aethiopica , in the Sanyati Basin, Lake Kariba, Zimbabwe: effect of plant morphological complexity.

  7. Symbiotic fungal associations in 'lower' land plants.

    Science.gov (United States)

    Read, D J; Ducket, J G; Francis, R; Ligron, R; Russell, A

    2000-06-29

    An analysis of the current state of knowledge of symbiotic fungal associations in 'lower' plants is provided. Three fungal phyla, the Zygomycota, Ascomycota and Basidiomycota, are involved in forming these associations, each producing a distinctive suite of structural features in well-defined groups of 'lower' plants. Among the 'lower' plants only mosses and Equisetum appear to lack one or other of these types of association. The salient features of the symbioses produced by each fungal group are described and the relationships between these associations and those formed by the same or related fungi in 'higher' plants are discussed. Particular consideration is given to the question of the extent to which root fungus associations in 'lower' plants are analogous to 'mycorrhizas' of 'higher' plants and the need for analysis of the functional attributes of these symbioses is stressed. Zygomycetous fungi colonize a wide range of extant lower land plants (hornworts, many hepatics, lycopods, Ophioglossales, Psilotales and Gleicheniaceae), where they often produce structures analogous to those seen in the vesicular-arbuscular (VA) mycorrhizas of higher plants, which are formed by members of the order Glomales. A preponderance of associations of this kind is in accordance with palaeohbotanical and molecular evidence indicating that glomalean fungi produced the archetypal symbioses with the first plants to emerge on to land. It is shown, probably for the first time, that glomalean fungi forming typical VA mycorrhiza with a higher plant (Plantago lanceolata) can colonize a thalloid liverwort (Pellia epiphylla), producing arbuscules and vesicles in the hepatic. The extent to which these associations, which are structurally analogous to mycorrhizas, have similar functions remains to be evaluated. Ascomycetous associations are found in a relatively small number of families of leafy liverworts. The structural features of the fungal colonization of rhizoids and underground axes of

  8. Factors associated with daily walking of dogs.

    Science.gov (United States)

    Westgarth, Carri; Christian, Hayley E; Christley, Robert M

    2015-05-19

    Regular physical activity is beneficial to the health of both people and animals. The role of regular exercise undertaken together, such as dog walking, is a public health interest of mutual benefit. Exploration of barriers and incentives to regular dog walking by owners is now required so that effective interventions to promote it can be designed. This study explored a well-characterised cross-sectional dataset of 276 dogs and owners from Cheshire, UK, for evidence of factors associated with the dog being walked once or more per day. Factors independently associated with daily walking included: number of dogs owned (multiple (vs. single) dogs negatively associated); size (medium and possibly large dogs (vs. small) positively associated); and number of people in the household (more people negatively associated). Furthermore, a number of factors related to the dog-owner relationship and the dog's behaviour were associated with daily walking, including: having acquired the dog for a hobby (positively associated); dog lying on furniture (positively associated); dog lying on laps (negatively associated); growling at household members (negatively associated); and playing chase games with the dog (negatively associated). These findings are consistent with the hypothesis that the strength and nature of the human-dog relationship incentivises dog walking, and that behavioural and demographic factors may affect dog walking via this mechanism. Future studies need to investigate how dog demographic and behavioural factors, plus owner behavioural factors and perceptions of the dog, influence the dog-human relationship in respect to the perceived support and motivation a dog can provide for walking.

  9. Helicobacter heilmannii-associated Gastritis: Clinicopathologic Findings and Comparison with Helicobacter pylori-associated Gastritis

    Science.gov (United States)

    Kwak, Ji Eun; Chang, Sun Hee; Kim, Hanseong; Chi, Je G.; Kim, Kyung-Ah; Yang, Jeon Ho; Lee, June Sung; Moon, Young-Soo; Kim, Kyoung-Mee

    2007-01-01

    The aims of this study were to evaluate the clinicopathologic features of Helicobacter heilmannii-associated gastritis and to compare H. heilmannii-associated gastritis with H. pylori-associated gastritis. We reviewed 5,985 consecutive gastric biopsy specimens. All cases of chronic gastritis with Helicobacter infection were evaluated with the Updated Sydney System, and the grades of all gastritis variables were compared between H. heilmannii-associated gastritis and H. pylori-associated gastritis groups. There were 10 cases of H. heilmannii-associated gastritis (0.17%) and 3,285 cases of H. pylori-associated gastritis (54.9%). The organisms were superficially located within the mucous layer without adhesion to epithelial cells. Interestingly, in one case many intracytoplasmic H. heilmannii organisms were observed in parietal cells with cell damage. A case of low-grade mucosa-associated lymphoid tissue (MALT) lymphoma concomitant with H. heilmannii infection was detected. Compared to H. pylori-associated gastritis, H. heilmannii-associated gastritis showed less severe neutrophilic activity (pgastritis devoid of erosion or ulcer (p=0.0309). In conclusion, we present the detailed clinicopathologic findings of H. heilmannii-associated gastritis compared to H. pylori-associated gastritis. H. heilmannii-associated gastritis is uncommon and milder than H. pylori-associated gastritis, however it may be noteworthy with respect to the development of MALT lymphoma. PMID:17297253

  10. Associations of advertisement-promotion-sponsorship-related ...

    African Journals Online (AJOL)

    ... Global Youth Tobacco Survey were used to estimate the prevalence of current cigarette smoking and assess whether exposure to pro-tobacco media and perception of the potential harm of secondhand smoke are associated with adolescents' smoking. Logistic regression analysis was used to estimate the associations.

  11. Implicit associative learning in synesthetes and nonsynesthetes.

    Science.gov (United States)

    Bankieris, Kaitlyn R; Aslin, Richard N

    2017-06-01

    Although cross-modal neural connections and genetic underpinnings are prominent in most current theories regarding the development of synesthesia, the potential role of associative learning in the formation of synesthetic associations has recently been revitalized. In this study, we investigated implicit associative learning in synesthetes and nonsynesthetes by recording reaction times to a target whose color was probabilistically correlated with its shape. A continuous measure of target detection at multiple time points during learning revealed that synesthetes and nonsynesthetes learn associations differently. Specifically, our results demonstrated a "fast-facilitation" learning effect for nonsynesthetes and a "fast-interference, slow-facilitation" learning effect for synesthetes. Additionally, synesthetes exhibited superior long-term memory for the learned associations in a surprise delayed retest. After this retest, participants implicitly learned new (shuffled) shape-color associations. We found that synesthetes experienced greater interference while learning these new shape-color associations. These results detail ways in which implicit associative learning and memory differ between synesthetes and nonsynesthetes.

  12. Associations between phenotypes of preeclampsia and thrombophilia.

    Science.gov (United States)

    Berks, Durk; Duvekot, Johannes J; Basalan, Hillal; De Maat, Moniek P M; Steegers, Eric A P; Visser, Willy

    2015-11-01

    Preeclampsia complicates 2-8% of all pregnancies. Studies on the association of preeclampsia with thrombophilia are conflicting. Clinical heterogeneity of the disease may be one of the explanations. The present study addresses the question whether different phenotypes of preeclampsia are associated with thrombophilia factors. Study design We planned a retrospective cohort study. From 1985 until 2010 women with preeclampsia were offered postpartum screening for the following thrombophilia factors: anti-phospholipid antibodies, APC-resistance, protein C deficiency and protein S deficiency, hyperhomocysteineamia, factor V Leiden and Prothrombin gene mutation. Hospital records were used to obtain information on phenotypes of the preeclampsia and placental histology. We identified 844 women with singleton pregnancies who were screened for thrombophilia factors. HELLP complicated 49% of pregnancies; Fetal growth restriction complicated 61% of pregnancies. Early delivery (preeclampsia was associated with protein S deficiency (p=0.01). Fetal growth restriction was associated with anti-phospholipid antibodies (ppreeclampsia was associated with anti-phospholipid antibodies (p=0.01). Extensive placental infarction (>10%) was associated with anti-phospholipid antibodies (ppreeclampsia, especially if complicated by fetal growth restriction, are associated with anti-phospholipid antibodies. Other phenotypes of preeclampsia, especially HELLP syndrome, were not associated with thrombophilia. We advise only to test for anti-phospholipid antibodies after early onset preeclampsia, especially if complicated by fetal growth restriction. We suggest enough evidence is presented to justify no further studies are needed. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  13. MRI features associated with acute appendicitis

    NARCIS (Netherlands)

    Leeuwenburgh, Marjolein M. N.; Jensch, Sebastiaan; Gratama, Jan W. C.; Spilt, Aart; Wiarda, Bart M.; van Es, H. Wouter; Cobben, Lodewijk P. J.; Bossuyt, Patrick M. M.; Boermeester, Marja A.; Stoker, Jaap; Bouma, Wim H.; Houdijk, Alexander P. J.; Richir, Milan C.; Stockmann, Hein B. A. C.; Wiezer, Marinus J.; Verhagen, Thijs

    2014-01-01

    To identify MRI features associated with appendicitis. Features expected to be associated with appendicitis were recorded in consensus by two expert radiologists on 223 abdominal MRIs in patients with suspected appendicitis. Nine MRI features were studied: appendix diameter >7 mm, appendicolith,

  14. Social networks of participants in voluntary associations

    NARCIS (Netherlands)

    Bekkers, René; Völker, Beate; Gaag, Martin van der; Flap, Henk

    2007-01-01

    In which respects do the social networks of members of voluntary associations differ from those of non-members? We derive contrasting predictions on the effects of characteristics of social networks of participants in voluntary associations from two types of social capital theory. Lin (2001), Flap

  15. Hierarchical document categorization using associative networks

    NARCIS (Netherlands)

    Bloom, Niels; Theune, Mariet; de Jong, Franciska M.G.; Klement, E.P.; Borutzky, W.; Fahringer, T.; Hamza, M.H.; Uskov, V.

    Associative networks are a connectionist language model with the ability to handle dynamic data. We used two associative networks to categorize random sets of related Wikipedia articles with only their raw text as input. We then compared the resulting categorization to a gold standard: the manual

  16. Anaemia prevalence and factors associated with haemoglobin ...

    African Journals Online (AJOL)

    Information on social-clinical characteristics, cancer type and associated factors as well as haemoglobin level before and after radiation were obtained. The prevalence of anaemia was determined as a proportion and linear regression was used to determine factors associated with haemoglobin change. Results: A total of ...

  17. Linkage disequilibrium and association mapping of drought ...

    African Journals Online (AJOL)

    Drought stress is a major abiotic stress that limits crop production. Molecular association mapping techniques through linkage disequilibrium (LD) can be effectively used to tag genomic regions involved in drought stress tolerance. With the association mapping approach, 90 genotypes of cotton Gossypium hirsutum, from ...

  18. Prune belly syndrome associated with incomplete VACTERL

    Directory of Open Access Journals (Sweden)

    Ghritlaharey R

    2007-01-01

    Full Text Available A Prune Belly syndrome with VATER/VACTERL association is an extremely rare. They are either stillborn or die within few days of life, only few such cases have been reported in literature. We are presenting here a male neonate of Prune Belly syndrome associated with incomplete VACTERL with brief review of literature.

  19. Association of Inflammatory Cytokines with Traditional and ...

    African Journals Online (AJOL)

    Background: Inflammatory processes are implicated in the etiology of cardiovascular disease (CVD). Data on the association of inflammatory markers with cardiovascular risk factors in Indian patients with CVD are limited. Aim: This study was conducted with the aim to evaluate the association of inflammatory markers with ...

  20. Macrofauna Associated with the Sponge Neopetrosia exigua ...

    African Journals Online (AJOL)

    in Marine Biology, Annamalai University, Parangipettai-608 502, Tamil Nadu, India. Keywords: Neopetrosia exigua, sponge, associated-fauna, species richness,. Mauritius, Indian Ocean. Abstract — The macrofaunal community associated with the sponge Neopetrosia exigua (Kirkpatrick, 1900) was studied across a ...

  1. Prevention of health care-associated infections.

    Science.gov (United States)

    Hsu, Vincent

    2014-09-15

    Health care-associated infections cause approximately 75,000 deaths annually, in addition to increasing morbidity and costs. Over the past decade, a downward trend in health care-associated infections has occurred nationwide. Basic prevention measures include administrative support, educating health care personnel, and hand hygiene and isolation precautions. Prevention of central line- or catheter-associated infections begins with avoidance of unnecessary insertion, adherence to aseptic technique when inserting, and device removal when no longer necessary. Specific recommendations for preventing central line-associated bloodstream infections include use of chlorhexidine for skin preparation, as a component of dressings, and for daily bathing of patients in intensive care units. Catheter-associated urinary tract infections are the most common device-related health care-associated infection. Maintaining a closed drainage system below the patient reduces the risk of infection. To prevent ventilator-associated pneumonia, which is associated with high mortality, mechanically ventilated patients should be placed in the semirecumbent position and receive antiseptic oral care. Prevention of surgical site infections includes hair removal using clippers, glucose control, and preoperative antibiotic prophylaxis. Reducing transmission of Clostridium difficile and multidrug-resistant organisms in the hospital setting begins with hand hygiene and contact precautions. Institutional efforts to reduce unnecessary antibiotic prescribing are also strongly recommended. Reducing rates of methicillin-resistant Staphylococcus aureus infection can be achieved through active surveillance cultures and decolonization therapy with mupirocin.

  2. Sequential association rules in atonal music

    NARCIS (Netherlands)

    Honingh, A.; Weyde, T.; Conklin, D.; Chew, E.; Childs, A.; Chuan, C.-H.

    2009-01-01

    This paper describes a preliminary study on the structure of atonal music. In the same way as sequential association rules of chords can be found in tonal music, sequential association rules of pitch class set categories can be found in atonal music. It has been noted before that certain pitch class

  3. Demographic and Lifestyle Variables Associated with Obesity

    Science.gov (United States)

    Worthy, Sheri L.; Lokken, Kristine; Pilcher, Kenneth; Boeka, Abbe

    2010-01-01

    Objective: Overweight and obesity rates are associated with chronic diseases and higher rates of disability and continue to rise in the United States and worldwide. The purpose of this study was to build on past research and further investigate demographic and lifestyle variables associated with increased body mass index (BMI: kg/m[squared]).…

  4. Algodistrophy and breast cancer: exists association?

    International Nuclear Information System (INIS)

    Vidal, N.; Valdivia, S.; Santos, C.; Morales, R.; Cano, R.; Salomon, M.; Cabrera, N.

    1992-01-01

    Algodistrophy is a well defined clinical entity in which usually it is possible to identify an association with trauma or other diseases. In the present article we describe three patients with breast carcinoma who developed algodistrophy an association no previously reported in literature, and analyzed the possible interrelation between both diseases. (Author). 46 refs., 2 tab., 5 fig

  5. Local Dynamic Stability Associated with Load Carrying

    Directory of Open Access Journals (Sweden)

    Jian Liu

    2013-03-01

    Conclusion: Current study confirmed the sensitivity of local dynamic stability measure in load carrying situation. It was concluded that load carrying tasks were associated with declined local dynamic stability, which may result in increased risk of fall accident. This finding has implications in preventing fall accidents associated with occupational load carrying.

  6. Association between rubella seropositivity and parity among ...

    African Journals Online (AJOL)

    Background: Rubella virus infection in the first 12 weeks of pregnancy causes miscarriages, stillbirths or fetal anomalies known as congenital rubella syndrome. Factors associated with rubella immunity include age and parity. No studies have been done to isolate the association of parity independent of age. Objective: To ...

  7. Volunteer Teachers' Associates as School Reformers.

    Science.gov (United States)

    Wagener, James W.

    This paper explores the role of volunteer teacher associates in school reform. Three theses are examined: (1) qualified and well trained volunteers as teachers' associates can be important in remedying the difficulties students experience in public school classrooms; (2) many public school reform efforts produce mixed results because of difficult…

  8. Associations between family suicide and personal suicidal ...

    African Journals Online (AJOL)

    The mean age was 13.3 years (range 13–15 years). There were significant associations between family suicide and students' self-reported involvement in physical fights, use of alcohol and concerns about physical health. Family suicide was associated with personal suicidal ideation, suicidal plans and suicide attempts.

  9. International Ergonomics Association Activities and Constituent Societies

    Science.gov (United States)

    1988-05-01

    Soci~t d’Ergonomie de Langue Francaise Hungary: IHungarian Society for Organization and Management Science Italy: Societa Italiana di Ergonomia ...Human Ergology Society Korea: Korean Ergonomics Society Mexico: Association Mexicana de Ergonomia New Zealand: New Zealand Ergonomics Soceity South...34.-, NATIONAL & REGIONAL ERGONOMICS SOCIETIES Association Mexicana de Ergonomia AC Javier Castellanos, Secretario Ejecutivo Periferico Sur 4271 - "Mexico 20

  10. Medullary sponge kidney associated with congenital hemihypertrophy.

    Science.gov (United States)

    Indridason, O S; Thomas, L; Berkoben, M

    1996-08-01

    Medullary sponge kidney is a developmental disorder characterized by ectatic and cystic malformation of the collecting ducts and tubules. Clinical manifestations include urinary tract infections, renal stones, and hematuria. It can be associated with other developmental disorders. A case of medullary sponge kidney associated with congenital hemihypertrophy, complicated by nephrocalcinosis and nephrolithiasis, is reported here.

  11. Journal of African Association of Physiological Sciences

    African Journals Online (AJOL)

    Journal of African Association of Physiological Sciences (J. Afr. Assoc. Physiol. Sci.) is an international, bi-annual official publication of African Association of Physiological Sciences. Both print and online forms are available. The journal is aimed at dissemination of information on diverse areas of research in Physiological ...

  12. ORIGINAL ARTICLE Prevalence and Associated Factors of ...

    African Journals Online (AJOL)

    2018-01-01

    Jan 1, 2018 ... Incidentally Diagnosed Prostatic Carcinoma… Daniel G.. et al. .... bladder cancer, 25-40% of them were found to have associated prostatic carcinoma (8,9). .... Table 2: Factors associated with incidentally diagnosed prostatic carcinoma among 152 participants who underwent TURP for presumed BPH.

  13. Injuries Associated with Thoracolumbar Fractures | Montshiwa | East ...

    African Journals Online (AJOL)

    Results: A total of 32 cases had been admitted with fractures of the thoracolumbar spine over the study period. Neurologic injury was associated with a thoracolumbar fracture in two-thirds of cases. An associated non-spinal injury was found in 37.5% of cases. Most of these injuries (77%) involved the extremities. The

  14. Reflections of a Latino Associate Professor

    Science.gov (United States)

    Peguero, Anthony A.

    2018-01-01

    The following reflection essay is about my experiences as a Latino Associate Professor who focuses on criminology, youth violence, juvenile justice, and the associated disparities with race, ethnicity, and immigration. I reflect about the "race and justice" job market, pursuing and establishing a Latina/o Criminology working group, often…

  15. 27 CFR 10.22 - Employee associations.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Employee associations. 10.22 Section 10.22 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS COMMERCIAL BRIBERY Commercial Bribery § 10.22 Employee associations. Gifts...

  16. Congenital pyloric atresia: clinical features, diagnosis, associated ...

    African Journals Online (AJOL)

    Congenital pyloric atresia: clinical features, diagnosis, associated anomalies, management and outcome. ... Conclusion: CPA is a very rare malformation that can be familial and inherited as an autosomal recessive. It can either occur as an isolated lesion with an excellent prognosis, or be associated with other anomalies.

  17. association between health status and visual functioning

    African Journals Online (AJOL)

    2014-01-31

    Jan 31, 2014 ... impairment of vision. In the recent report that obesity is negatively associated with visual acuity (Bergman et al., 2004) supports of our finding, but the ocular conditions underlying this association and the potential implications remain unclear (Cheung and. Wong, 2007). Nevertheless, Momeni-Moghaddam ...

  18. Role of associativity in Ramsey algebras

    Indian Academy of Sciences (India)

    Andrew Rajah

    2017-11-02

    Nov 2, 2017 ... to understand the role associativity plays in a binary system being a Ramsey algebra. Specifically, we show that the nonassociative Moufang loop of octonions is not a Ramsey algebra. Keywords. Binary systems; Ramsey algebras; octonions; semigroups; associativity; nonassociative Moufang loops ...

  19. Implicit Measures of Association in Psychopathology Research

    NARCIS (Netherlands)

    Roefs, Anne; Huijding, Jorg; Smulders, Fren T. Y.; MacLeod, Colin M.; de Jong, Peter J.; Wiers, Reinout W.; Jansen, Anita T. M.

    Studies obtaining implicit measures of associations in Diagnostic and Statistical Manual of Mental Disorders (4th ed., Text Revision; American Psychiatric Association, 2000) Axis 1 psychopathology are organized into three categories: (a) studies comparing groups having a disorder with controls, (b)

  20. Implicit Measures of Association in Psychopathology Research

    Science.gov (United States)

    Roefs, Anne; Huijding, Jorg; Smulders, Fren T. Y.; MacLeod, Colin M.; de Jong, Peter J.; Wiers, Reinout W.; Jansen, Anita T. M.

    2011-01-01

    Validity;Measures (Individuals);Studies obtaining implicit measures of associations in "Diagnostic and Statistical Manual of Mental Disorders" (4th ed., Text Revision; American Psychiatric Association, 2000) Axis I psychopathology are organized into three categories: (a) studies comparing groups having a disorder with controls, (b) experimental…

  1. Implicit measures of association in psychopathology research

    NARCIS (Netherlands)

    Roefs, A.; Huijding, J.; Smulders, F.T.Y.; MacLeod, C.M.; de Jong, P.J.; Wiers, R.W.; Jansen, A.T.M.

    2011-01-01

    Studies obtaining implicit measures of associations in Diagnostic and Statistical Manual of Mental Disorders (4th ed., Text Revision; American Psychiatric Association, 2000) Axis I psychopathology are organized into three categories: (a) studies comparing groups having a disorder with controls, (b)

  2. Hearing impairment associated with oral terbinafine use

    NARCIS (Netherlands)

    Scholl, Joep; Van Grootheest, Kees; Van Puijenbroek, Eugene

    Background: The Netherlands Pharmacovigilance Centre Lareb received six reports of hearing impairment in association with oral terbinafine use. This study describes these cases and provides support for this association from the Lareb database of spontaneous ADR reporting and from Vigibase, the

  3. Associations between intimate partner violence, depression, and ...

    African Journals Online (AJOL)

    One type of IPV (sexual) was significantly associated with depression, whereas psychological abuse and femicide risk or danger was correlated with suicidal behavior. Conclusion: A high proportion of women with IPV suffered from depression and suicidal behavior. The study provides evidence of an association between ...

  4. Cross-cultural color-odor associations

    NARCIS (Netherlands)

    Levitan, C.A.; Ren, J.; Boesveldt, S.; Chan, J.; McKenzie, K.J.; Levin, J.A.; Leong, C.X.; Bosch, van den J.F.

    2014-01-01

    Colors and odors are associated; for instance, people typically match the smell of strawberries to the color pink or red. These associations are forms of crossmodal correspondences. Recently, there has been discussion about the extent to which these correspondences arise for structural reasons

  5. Semantic association ranking schemes for information retrieval ...

    Indian Academy of Sciences (India)

    Most of the Information Retrieval (IR) techniques are based on representing the documents using the traditional vector space and probabilistic language model i.e., bag-of- words model. In this paper, associations among words in the documents are assessed and it is expressed in Term Association Graph model to represent ...

  6. Prevalence and factors associated with depressive symptoms ...

    African Journals Online (AJOL)

    This study further suggests gender differences in that for women, depressive symptoms were associated with intimate partner violence and lower perceptions of community cohesion, while for men the associations were with a mother's death and relationship conflict. Journal of Child and Adolescent Mental Health 2013, ...

  7. Pregnancy- and lactation-associated osteoporosis

    African Journals Online (AJOL)

    2012-08-08

    Aug 8, 2012 ... Case Study: Pregnancy- and lactation-associated osteoporosis. 149. 2012 Volume 17 No 3. JEMDSA. Introduction. Osteoporosis, a condition that is usually associated with ageing and which is found in postmenopausal women, can present during pregnancy and lactation. A syndrome of spontaneous ...

  8. Semantic association ranking schemes for information retrieval ...

    Indian Academy of Sciences (India)

    Abstract. Most of the Information Retrieval (IR) techniques are based on repre- senting the documents using the traditional vector space and probabilistic language model i.e., bag-of- words model. In this paper, associations among words in the docu- ments are assessed and it is expressed in Term Association Graph model ...

  9. Investigating the association between diabetes mellitus, depression ...

    African Journals Online (AJOL)

    Background. Diabetes mellitus (DM) may increase the risk of depression as a result of a sense of threat of debilitating complications or because of associated lifestyle changes. Depression may increase the risk of type 2 diabetes as a result of poor health behaviours. Objective. To determine the association between ...

  10. Genetic association studies in lumbar disc degeneration

    DEFF Research Database (Denmark)

    Eskola, Pasi J; Lemmelä, Susanna; Kjaer, Per

    2012-01-01

    Low back pain is associated with lumbar disc degeneration, which is mainly due to genetic predisposition. The objective of this study was to perform a systematic review to evaluate genetic association studies in lumbar disc degeneration as defined on magnetic resonance imaging (MRI) in humans....

  11. Colon cancer associated transcripts in human cancers.

    Science.gov (United States)

    Chen, Yincong; Xie, Haibiao; Gao, Qunjun; Zhan, Hengji; Xiao, Huizhong; Zou, Yifan; Zhang, Fuyou; Liu, Yuchen; Li, Jianfa

    2017-10-01

    Long non-coding RNAs serve as important regulators in complicated cellular activities, including cell differentiation, proliferation and death. Dysregulation of long non-coding RNAs occurs in the formation and progression of cancers. The family of colon cancer associated transcripts, long non-coding RNAs colon cancer associated transcript-1 and colon cancer associated transcript-2 are known as oncogenes involved in various cancers. Colon cancer associated transcript-1 is a novel lncRNA located in 8q24.2, and colon cancer associated transcript-2 maps to the 8q24.21 region encompassing rs6983267. Colon cancer associated transcripts have close associations with clinical characteristics, such as lymph node metastasis, high TNM stage and short overall survival. Knockdown of them can reverse the malignant phenotypes of cancer cells, including proliferation, migration, invasion and apoptosis. Moreover, they can increase the expression level of c-MYC and oncogenic microRNAs via activating a series of complex mechanisms. In brief, the family of colon cancer associated transcripts may serve as potential biomarkers or therapeutic targets for human cancers. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  12. Large recurrent microdeletions associated with schizophrenia

    DEFF Research Database (Denmark)

    Stefansson, H.; Rujescu, D.; Cichon, S.

    2008-01-01

    Reduced fecundity, associated with severe mental disorders, places negative selection pressure on risk alleles and may explain, in part, why common variants have not been found that confer risk of disorders such as autism, schizophrenia and mental retardation. Thus, rare variants may account...... and autism. In a genome-wide search for CNVs associating with schizophrenia, we used a population-based sample to identify de novo CNVs by analysing 9,878 transmissions from parents to offspring. The 66 de novo CNVs identified were tested for association in a sample of 1,433 schizophrenia cases and 33......,250 controls. Three deletions at 1q21.1, 15q11.2 and 15q13.3 showing nominal association with schizophrenia in the first sample (phase I) were followed up in a second sample of 3,285 cases and 7,951 controls (phase II). All three deletions significantly associate with schizophrenia and related psychoses...

  13. Ranked Multi-Label Rules Associative Classifier

    Science.gov (United States)

    Thabtah, Fadi

    Associative classification is a promising approach in data mining, which integrates association rule discovery and classification. In this paper, we present a novel associative classification technique called Ranked Multilabel Rule (RMR) that derives rules with multiple class labels. Rules derived by current associative classification algorithms overlap in their training data records, resulting in many redundant and useless rules. However, RMR removes the overlapping between rules using a pruning heuristic and ensures that rules in the final classifier do not share training records, resulting in more accurate classifiers. Experimental results obtained on twenty data sets show that the classifiers produced by RMR are highly competitive if compared with those generated by decision trees and other popular associative techniques such as CBA, with respect to prediction accuracy.

  14. The different roles of the Staff association

    CERN Multimedia

    Staff Association

    2012-01-01

    The statutory role of the CERN Staff Association is defined in Chapter VII of the Staff Rules and Regulations. The means of the Association to realize its aims are described in Article I.1.3 of the Statutes of the CERN Staff Association. Generally speaking, its aims are “To serve and defend the economic, social, professional and moral interests of its members and all CERN staff“. Usually we deal with professional and social issues (employment conditions, defence of collective or individual rights, promotion of basic research...). But the Association also plays a role of integration (clubs promoting cultural, humanitarian, and sport or offering entertainment, organizing exhibitions and conferences) and it can promote actions to provide its members with material or social advantages (Interfon, commercial offers). Advantageous commercial offers In recent years the Association was able to negotiate with business or cultural partners benefits for its members. A full list can be found on our...

  15. Intramolecular Association within the SAFT Framework

    DEFF Research Database (Denmark)

    Avlund, Ane Søgaard; Kontogeorgis, Georgios; Chapman, Walter G.

    2011-01-01

    the contribution to the Helmholtz free energy from association (inter- as well as intramolecularly) at equilibrium. Sear and Jackson rederived the contribution to the Helmholtz free energy from association from the theory by Wertheim [J. Stat. Phys. 42 (3–4), 459 (1986)] with inclusion of intramolecular...... association, and using this approach we obtain an expression for the Helmholtz free energy that is valid also at non-equilibrium states (with respect to hydrogen bonds), which is very useful when calculating derivatives.......A general theory for modelling intramolecular association within the SAFT framework is proposed. Sear and Jackson [Phys. Rev. E. 50 (1), 386 (1994)] and Ghonasgi and Chapman [J. Chem. Phys. 102 (6), 2585 (1995)] have previously extended SAFT to include intramolecular association for chains with two...

  16. The association between oxytocin and social capital.

    Directory of Open Access Journals (Sweden)

    Takeo Fujiwara

    Full Text Available BACKGROUND: Oxytocin is known to be related to social behaviors, including trust. However, few studies have investigated the association between oxytocin levels and social capital. Thus, we tested the hypothesis that endogenous oxytocin levels are positively associated with social capital. We also considered whether the association differed across gender because previous studies have shown differential effects of OT on social behaviors depending on gender. METHODS: We recruited a convenience sample of 50 women and 31 men in Japan via community sampling from whom we obtained urine sample with which to measure oxytocin levels. Individual-level cognitive social capital (social trust and mutual aid and structural social capital (community participation were assessed using a questionnaire. We used multivariate regression, adjusted for covariates (age, number of children, self-rated health, and education, and stratified by gender to consider associations between oxytocin and social capital. RESULTS: Among women, oxytocin was inversely associated with social trust and mutual aid (p<0.05. However, women participating in only 1 organization in the community showed higher oxytocin than women who participated in either no organizations (p<0.05 or 2 or more organization (i.e. inverse-U shape association. Among men, no association was observed between oxytocin and either form of cognitive and structural social capital. CONCLUSION: Women who perceived low cognitive social capital showed higher oxytocin levels, while structural social capital showed inverse-U shape association with oxytocin. No association between oxytocin and social capital was found among men. Further study is needed to elucidate why oxytocin was inversely associated with cognitive social capital only among women.

  17. MRI features associated with acute appendicitis

    Energy Technology Data Exchange (ETDEWEB)

    Leeuwenburgh, Marjolein M.N. [University of Amsterdam, Department of Surgery, Academic Medical Center, Amsterdam (Netherlands); University of Amsterdam, Department of Radiology, Academic Medical Center, Amsterdam (Netherlands); Academic Medical Center, Department of Radiology (G1-223.1), Amsterdam (Netherlands); Jensch, Sebastiaan [Sint Lucas Andreas Hospital, Department of Radiology, Amsterdam (Netherlands); Gratama, Jan W.C. [Gelre Hospitals, Department of Radiology, Apeldoorn (Netherlands); Spilt, Aart [Kennemer Gasthuis, Department of Radiology, Haarlem (Netherlands); Wiarda, Bart M. [Alkmaar Medical Center, Department of Radiology, Alkmaar (Netherlands); Es, H.W. van [Sint Antonius Hospital, Department of Radiology, Nieuwegein (Netherlands); Cobben, Lodewijk P.J. [Haaglanden Medical Center, Department of Radiology, Leidschendam (Netherlands); Bossuyt, Patrick M.M. [University of Amsterdam, Department of Clinical Epidemiology, Academic Medical Center, Amsterdam (Netherlands); Boermeester, Marja A. [University of Amsterdam, Department of Surgery, Academic Medical Center, Amsterdam (Netherlands); Stoker, Jaap [University of Amsterdam, Department of Radiology, Academic Medical Center, Amsterdam (Netherlands); Collaboration: on behalf of the OPTIMAP study group

    2014-01-15

    To identify MRI features associated with appendicitis. Features expected to be associated with appendicitis were recorded in consensus by two expert radiologists on 223 abdominal MRIs in patients with suspected appendicitis. Nine MRI features were studied: appendix diameter >7 mm, appendicolith, peri-appendiceal fat infiltration, peri-appendiceal fluid, absence of gas in the appendix, appendiceal wall destruction, restricted diffusion of the appendiceal wall, lumen or focal fluid collections. Appendicitis was assigned as the final diagnosis in 117/223 patients. Associations between imaging features and appendicitis were evaluated with logistic regression analysis. All investigated features were significantly associated with appendicitis in univariate analysis. Combinations of two and three features were associated with a probability of appendicitis of 88 % and 92 %, respectively. In patients without any of the nine features, appendicitis was present in 2 % of cases. After multivariate analysis, only an appendix diameter >7 mm, peri-appendiceal fat infiltration and restricted diffusion of the appendiceal wall were significantly associated with appendicitis. The probability of appendicitis was 96 % in their presence and 2 % in their absence. An appendix diameter >7 mm, peri-appendiceal fat infiltration and restricted diffusion of the appendiceal wall have the strongest association with appendicitis on MRI. (orig.)

  18. The Staff Association and its history

    CERN Multimedia

    Staff Association

    2015-01-01

    The Staff Association will celebrate its 60th birthday in the spring of 2015. We are collecting all information about the sixty years of the Staff Association. In particular, we are looking at publications of the Staff Association, which started with the “Staff Association Journal”, in 1955, which later became “Le Proton déchainé”, then, more simply, “Proton” in 1982 (the figure on the left shows the different mutations of our magazine). In our collection we are missing a few issues, in particular № 1 (dated mid-1955).     Dear reader, if have any old issues of this magazine, or of Graviton (figure on the right), another magazine edited by the Staff Association, or any other material or information that might help us document the history of the Staff Association, we would very much like to have a copy of the material or your contribution (written or oral). Please contact the Staff Association Sec...

  19. Analyzing microarray data using quantitative association rules.

    Science.gov (United States)

    Georgii, Elisabeth; Richter, Lothar; Rückert, Ulrich; Kramer, Stefan

    2005-09-01

    We tackle the problem of finding regularities in microarray data. Various data mining tools, such as clustering, classification, Bayesian networks and association rules, have been applied so far to gain insight into gene-expression data. Association rule mining techniques used so far work on discretizations of the data and cannot account for cumulative effects. In this paper, we investigate the use of quantitative association rules that can operate directly on numeric data and represent cumulative effects of variables. Technically speaking, this type of quantitative association rules based on half-spaces can find non-axis-parallel regularities. We performed a variety of experiments testing the utility of quantitative association rules for microarray data. First of all, the results should be statistically significant and robust against fluctuations in the data. Next, the approach should be scalable in the number of variables, which is important for such high-dimensional data. Finally, the rules should make sense biologically and be sufficiently different from rules found in regular association rule mining working with discretizations. In all of these dimensions, the proposed approach performed satisfactorily. Therefore, quantitative association rules based on half-spaces should be considered as a tool for the analysis of microarray gene-expression data. The code is available from the authors on request.

  20. Associated Information Increases Subjective Perception of Duration.

    Science.gov (United States)

    Schweitzer, Richard; Trapp, Sabrina; Bar, Moshe

    2017-08-01

    Our sense of time is prone to various biases. For instance, one factor that can dilate an event's perceived duration is the violation of predictions; when a series of repeated stimuli is interrupted by an unpredictable oddball. On the other hand, when the probability of a repetition itself is manipulated, predictable conditions can also increase estimated duration. This suggests that manipulations of expectations have different or even opposing effects on time perception. In previous studies, expectations were generated because stimuli were repeated or because the likelihood of a sequence or a repetition was varied. In the natural environment, however, expectations are often built via associative processes, for example, the context of a kitchen promotes the expectation of plates, appliances, and other associated objects. Here, we manipulated such association-based expectations by using oddballs that were either contextually associated or nonassociated with the standard items. We find that duration was more strongly overestimated for contextually associated oddballs. We reason that top-down attention is biased toward associated information, and thereby dilates subjective duration for associated oddballs. Based on this finding, we propose an interplay between top-down attention and predictive processing in the perception of time.

  1. Visual attention to features by associative learning.

    Science.gov (United States)

    Gozli, Davood G; Moskowitz, Joshua B; Pratt, Jay

    2014-11-01

    Expecting a particular stimulus can facilitate processing of that stimulus over others, but what is the fate of other stimuli that are known to co-occur with the expected stimulus? This study examined the impact of learned association on feature-based attention. The findings show that the effectiveness of an uninformative color transient in orienting attention can change by learned associations between colors and the expected target shape. In an initial acquisition phase, participants learned two distinct sequences of stimulus-response-outcome, where stimuli were defined by shape ('S' vs. 'H'), responses were localized key-presses (left vs. right), and outcomes were colors (red vs. green). Next, in a test phase, while expecting a target shape (80% probable), participants showed reliable attentional orienting to the color transient associated with the target shape, and showed no attentional orienting with the color associated with the alternative target shape. This bias seemed to be driven by learned association between shapes and colors, and not modulated by the response. In addition, the bias seemed to depend on observing target-color conjunctions, since encountering the two features disjunctively (without spatiotemporal overlap) did not replicate the findings. We conclude that associative learning - likely mediated by mechanisms underlying visual object representation - can extend the impact of goal-driven attention to features associated with a target stimulus. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Prefrontal Dopamine in Associative Learning and Memory

    Science.gov (United States)

    Puig, M. Victoria; Antzoulatos, Evan G.; Miller, Earl K.

    2014-01-01

    Learning to associate specific objects or actions with rewards and remembering the associations are everyday tasks crucial for our flexible adaptation to the environment. These higher-order cognitive processes depend on the prefrontal cortex (PFC) and frontostriatal circuits that connect areas in the frontal lobe with the striatum in the basal ganglia. Both structures are densely innervated by dopamine (DA) afferents that originate in the midbrain. Although the activity of DA neurons is thought to be important for learning, the exact role of DA transmission in frontostriatal circuits during learning-related tasks is still unresolved. Moreover, the neural substrates of this modulation are poorly understood. Here, we review our recent work in monkeys utilizing local pharmacology of DA agents in the PFC to investigate the cellular mechanisms of DA modulation of associative learning and memory. We show that blocking both D1 and D2 receptors in the lateral PFC impairs learning of new stimulus-response associations and cognitive flexibility, but not the memory of highly familiar associations. In addition, D2 receptors may also contribute to motivation. The learning deficits correlated with reductions of neural information about the associations in PFC neurons, alterations in global excitability and spike synchronization, and exaggerated alpha and beta neural oscillations. Our findings provide new insights into how DA transmission modulate associative learning and memory processes in frontostriatal systems. PMID:25241063

  3. HLA and disease: guilt by association.

    Science.gov (United States)

    Howell, W M

    2014-02-01

    It is now over forty years since the first associations between particular HLA antigens and disease susceptibility were described, and the identification of large numbers HLA-associated diseases parallels our increased understanding of the genetic complexity of the HLA system and its extensive polymorphism. However, surprisingly and frustratingly, clear identification of the underlying mechanisms resulting in a causative role for HLA polymorphism in the molecular immunopathogenesis of individual HLA-associated diseases remains the exception rather than the rule. This review, while not intended to be a comprehensive catalogue of HLA-associated diseases, aims to revisit a number of well known and more recently described HLA-associated diseases as exemplars of our current understanding of the underlying molecular mechanisms which may result in genetic disease predisposition. Such mechanisms may act as pointers for further investigations in other HLA-associated diseases. The clinical utility of specific HLA disease associations in disease diagnosis/exclusion is also considered. © 2013 John Wiley & Sons Ltd.

  4. [Mortality risk factors in ventilator associated pneumonia].

    Science.gov (United States)

    Iribarren B, Osvaldo; Aranda T, Jacquelin; Dorn H, Lilian; Ferrada M, Mónica; Ugarte E, Héctor; Koscina M, Vinka; López R, Daniel; Morel F, Mauro

    2009-06-01

    to identify lethality and mortality rates and, mortality risk factors in ventilator associated pneumonia (VAP) on 114 patients treated between 2000 and 2007. Twenty five risk factors were analyzed, emphasizing age, gender, APACHE score, associated diseases, hypotension at intake, coma, hospitalization time, length of time of ventilation, emergency intubation, reintubation, previous antibiotics, and resistant microrganisms. Lethality was 25.4 %, and mortality was 2.4 %. Association between lethality, and APACHE score was found (p: 0.04). Critical APACHE value was 22. Also, in early pneumonia, association between lethality and nasogastric tube (p: 0.01, I.C. 95 % 1.39 - 6.35) was found. No association with late pneumonia was found among mortality and clinical practices. Death's RR (relative risk) increase in following values with: previous neurological disease 2.7 (p: 0.15, IC 95 % 1.15 - 6.5), neurological comaRR 2 (p: 0.2, IC 95 % 0.54 - 7.53). Nevertheless, at multivariate analysis no mortality risk factors were identified. Fair association with time in ICU (p: 0.051 IC 95 % 0.99 - 1.17) and, male sex (p: 0.051, IC 95 % 0.99 - 6.72) was found. We observed multiple factors associated to mortality in VAP: use of nasogastric catheter, longer stay in ICU and male sex.

  5. Molecular piracy of Kaposi's sarcoma associated herpesvirus.

    Science.gov (United States)

    Choi, J; Means, R E; Damania, B; Jung, J U

    2001-01-01

    Kaposi's Sarcoma associated Herpesvirus (KSHV) is the most recently discovered human tumor virus and is associated with the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and Multicentric Casttleman's disease. KSHV contains numerous open reading frames with striking homology to cellular genes. These viral gene products play a variety of roles in KSHV-associated pathogenesis by disrupting cellular signal transduction pathways, which include interferon-mediated anti-viral responses, cytokine-regulated cell growth, apoptosis, and cell cycle control. In this review, we will attempt to cover our understanding of how viral proteins deregulate cellular signaling pathways, which ultimately contribute to the conversion of normal cells to cancerous cells.

  6. Hypophosphatemic rickets associated with giant hairy nevus

    Directory of Open Access Journals (Sweden)

    Sameer Aggarwal

    2013-01-01

    Full Text Available The association of multisystem pathologic conditions and epidermal nevi, known as the epidermal nevus syndrome, includes disorders of bone, central nervous system, eye, kidney, vasculature and skin. Rarely, congenital nevomelanocytic nevus also known as hairy nevus has also been reported in association with hypophosphatemic rickets. Studies suggest that phosphaturia, caused by circulating factors, called "phosphatonins" may be secreted by an epidermal or hairy nevus. We report here, a rare case of hypophosphatemic rickets associated with a giant hairy nevus in a 10-year-old boy.

  7. Autoimmune hepatitis in association with lymphocytic colitis.

    LENUS (Irish Health Repository)

    Cronin, Edmond M

    2012-02-03

    Autoimmune hepatitis is a rare, chronic inflammatory disorder which has been associated with a number of other auto-immune conditions. However, there are no reports in the medical literature of an association with microscopic (lymphocytic) colitis. We report the case of a 53-year-old woman with several autoimmune conditions, including lymphocytic colitis, who presented with an acute hepatitis. On the basis of the clinical features, serology, and histopathology, we diagnosed autoimmune hepatitis. To our knowledge, this is the first report of autoimmune hepatitis in association with lymphocytic colitis, and lends support to the theory of an autoimmune etiology for lymphocytic colitis.

  8. Thromboembolic stroke associated with thoracic outlet syndrome.

    Science.gov (United States)

    Meumann, Ella M; Chuen, Jason; Fitt, Greg; Perchyonok, Yuliya; Pond, Franklin; Dewey, Helen M

    2014-05-01

    Thoracic outlet syndrome occurs due to compression of the neurovascular structures as they exit the thorax. Subclavian arterial compression is usually due to a cervical rib, and is rarely associated with thromboembolic stroke. The mechanism of cerebral embolisation associated with the thoracic outlet syndrome is poorly understood, but may be due to retrograde propagation of thrombus or transient retrograde flow within the subclavian artery exacerbated by arm abduction. We report an illustrative patient and review the clinical features, imaging findings and management of stroke associated with thoracic outlet syndrome. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Bilateral maculopathy associated with Pierre Robin sequence.

    Science.gov (United States)

    Witmer, Matthew T; Vasan, Ryan; Levy, Richard; Davis, Jessica; Chan, R V Paul

    2012-08-01

    Pierre Robin sequence has been associated with a number of ocular complications, including myopia, strabismus, Möbius syndrome, nasolacrimal duct obstruction, glaucoma, cataract, microphthalmos, coloboma of choroid, and retinal detachment. We report a 10-day-old boy who presented with micrognathia, glossoptosis, and cleft palate as well as multiple congenital anomalies. Ophthalmic examination was notable for bilateral maculopathy, with focal areas of retinal and retinal pigment epithelial atrophy. The association of Pierre Robin sequence and maculopathy has been reported only twice previously. Copyright © 2012 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.

  10. Territorial Rights, Political Association, and Immigration

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2013-01-01

    is therefore in need of additional justification. The paper considers Christopher Heath Wellman’s liberal proposal for justifying the right to control immigration, which understands the right as derivative of a general right to freedom of association held collectively by the people of the state. The paper...... argues that state legitimacy and freedom of political association fail to connect in the way required to justify a right to control immigration. Wellman’s argument conflates the state as an institution and the people as a political collective and elides the difference between territorial jurisdiction...... and associational freedom....

  11. Marked chromosomes associations in catarrhine monkeys, with a note on chromosome associations in other primate groups

    NARCIS (Netherlands)

    Boer, L.E.M. de

    In metaphase figures, obtained from cultures of whole blood, associations of the marked chromosomes were found in species of the following genera: Macaca, Cercocebus, Cercopithecus and Symphalangus. The different types of these associations are discussed. A note is given on chromosome associations

  12. Functional imaging of implicit marijuana associations during performance on an Implicit Association Test (IAT)

    NARCIS (Netherlands)

    Ames, S.L.; Grenard, J.L.; Stacy, A.W.; Xiao, L.; He, Q.; Wong, S.W; Xue, G.; Wiers, R.W.; Bechara, A.

    2013-01-01

    This research evaluated the neural correlates of implicit associative memory processes (habit-based processes) through the imaging (fMRI) of a marijuana Implicit Association Test. Drug-related associative memory effects have been shown to consistently predict level of drug use. To observe

  13. Glycerine associated molecules with herbicide for controlling ...

    African Journals Online (AJOL)

    Glycerine associated molecules with herbicide for controlling Adenocalymma peregrinum in cultivated pastures. Rejanne Lima Arruda, Melquezedeque do Vale Nunes, Paulo Roberto da Silva, Fernando Ferreira Leao, Renato de Almeida Sarmento, Thomas Viera Nunes, Eduardo Andrea Lemus Erasmo ...

  14. Business Associations, Lobbying, and Endogenous Institutions

    NARCIS (Netherlands)

    Larrain Aylwin, M.J.; Prüfer, J.O.

    2014-01-01

    Are business associations - private, formal, nonprofit organizations designed to promote the common interests of their members - positive or negative for the economy and overall welfare? Scholars from institutional and organizational economics, on the one side, and from industrial organization, law

  15. American Evaluation Association Guiding Principles for Evaluators

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-01-18

    Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles they can expect to be upheld by professional evaluators.

  16. Benefits and Risks Associated with Landscapes

    Science.gov (United States)

    To fully reap the benefits that lawns and landscapes can provide our urban and suburban communities, these green spaces must be well-maintained. The landscaping initiative helps manage the benefits and risks associated with lawn care.

  17. Estrogen-associated severe hypertriglyceridemia with pancreatitis.

    Science.gov (United States)

    Aljenedil, Sumayah; Hegele, Robert A; Genest, Jacques; Awan, Zuhier

    Estrogen, whether therapeutic or physiologic, can cause hypertriglyceridemia. Hypertriglyceridemia-induced pancreatitis is a rare complication. We report 2 women who developed estrogen-associated severe hypertriglyceridemia with pancreatitis. The first patient developed pancreatitis secondary to hypertriglyceridemia associated with in vitro fertilization cycles. Marked reduction in her triglyceride was achieved with dietary restrictions and fibrate. The second patient developed pancreatitis secondary to hypertriglyceridemia during her pregnancies. She was noncompliant with the treatment; therefore, her triglyceride remained high after delivery. In both patients, no hypertriglyceridemia-associated genes mutations were identified, although the second patient had strong polygenic susceptibility to hypertriglyceridemia. Estrogen-induced severe hypertriglyceridemia with pancreatitis can be a life-threatening condition. Screening in high-risk patients is crucial to prevent subsequent complications. Copyright © 2016 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  18. Seizures associated with Lupus during pregnancy

    OpenAIRE

    Aoki, Shigeru; Kobayashi, Natsuko; Mochimaru, Aya; Takahashi, Tsuneo; Hirahara, Fumiki

    2016-01-01

    Key Clinical Message A sudden flare of previously stable SLE may give rise to CNS lupus. During pregnancy, seizures associated with CNS lupus can cause hypoxic?ischemic encephalopathy (HIE) in the infant.

  19. Is occupational stress associated with work engagement ?

    Science.gov (United States)

    Padula, Rosimeire Simprini; Chiavegato, Luciana Dias; Cabral, Cristina Maria Nunes; Almeid, Talita; Ortiz, Thais; Carregaro, Rodrigo Luiz

    2012-01-01

    The occupational stress is associated with dissatisfaction, excessive demand at work and personal factors. Those factors can reduce work performance and can predispose workers to various diseases. Workers' health may be protected if there is encouragement to face challenges, which may lessen the impact on psychological and somatic stress and thus have greater personal and professional satisfaction. The aim of this study was to evaluate the association between occupational stress and work engagement. Participated in this study 457 male and female workers of a metallurgical industry. Subjects answered personal data, and the Job Stress Scale and Utrecht Work Engagement Scale were applied. Results showed an association between occupational stress and work engagement (P=0,001). The way the individual deals with his frustrations, or rather the work engagement, is associated with the occupational stress.

  20. Journal of the Association of Nigerian Musicologists

    African Journals Online (AJOL)

    The objectives of Journal of the Association of Nigerian Musicologists are to develop musicology as a field through research and publication of highly standard articles; to enhance quality scholarship in Nigerian music and to promote Nigerian musicology internationally ...

  1. Agranulocytosis and granulocytopenia associated with quetiapine

    NARCIS (Netherlands)

    Ruhé, H. G.; Becker, H. E.; Jessurun, P.; Marees, C. H.; Heeringa, M.; Vermeulen, H. D.

    2001-01-01

    Quetiapine is a recently introduced atypical antipsychotic. Although adverse effects are mainly mild, more serious infrequent adverse effects including leucopenia are mentioned. We describe three case-reports concerning haematological adverse effects of quetiapine. Quetiapine was associated with

  2. Kocuria kristinae infection associated with acute cholecystitis

    Directory of Open Access Journals (Sweden)

    Chan Edmond CH

    2005-07-01

    Full Text Available Abstract Background Kocuria, previously classified into the genus of Micrococcus, is commonly found on human skin. Two species, K. rosea and K. kristinae, are etiologically associated with catheter-related bacteremia. Case presentation We describe the first case of K. kristinae infection associated with acute cholecystitis. The microorganism was isolated from the bile of a 56-year old Chinese man who underwent laparoscopic cholecystectomy. He developed post-operative fever that resolved readily after levofloxacin treatment. Conclusion Our report of K. kristinae infection associated with acute cholecystitis expands the clinical spectrum of infections caused by this group of bacteria. With increasing number of recent reports describing the association between Kocuria spp. and infectious diseases, the significance of their isolation from clinical specimens cannot be underestimated. A complete picture of infections related to Kocuria spp. will have to await the documentation of more clinical cases.

  3. Association Euratom - Confederation Suisse: Report 1991 - 1992

    International Nuclear Information System (INIS)

    1993-01-01

    This is the first integrated biannual report of the Swiss-Euratom Association, one of the twelve Associations of the European programme for controlled nuclear fusion research. Up until now, each Swiss group presented its activities within the framework of the institution to which it belonged. The report of the CRPP, whose research is almost entirely dedicated to fusion, gave a good picture of the Swiss programme in physics but the important technological activities of the PSI were described separately in the PSI report, out of its natural context and buried amongst a multitude of other projects. We hope that this report will contribute to a better knowledge of the Association and appreciation of its work. It is also the answer to an old Euratom desire to have each Association publish such an integrated report of its activities. (author) figs., tabs., refs

  4. Catheter-Associated Urinary Tract Infections

    Science.gov (United States)

    ... Vaccine Safety Frequently Asked Questions about Catheter-associated Urinary Tract Infections Recommend on Facebook Tweet Share Compartir What is ... an incision above the pubis. What is a urinary tract infection? A urinary tract infection (UTI) is an infection ...

  5. Database Management Using Optical Associative Memory

    National Research Council Canada - National Science Library

    Ralston, Lynda

    1998-01-01

    A concept was developed for an optical based associative memory system that accepts a query request from a user, searches the disk for the location of the information and ensures maximum efficiency in data recovery...

  6. Associations between baseline allergens and polysensitization

    DEFF Research Database (Denmark)

    Carlsen, B.C.; Menne, T.; Johansen, J.D.

    2008-01-01

    : Seven allergens - parabens mix, N-isopropyl-N-phenyl-p-phenylenediamine, sesquiterpene lactone mix, wool alcohols, potassium dichromate, Myroxylon pereirae, and cobalt chloride - showed statistically significant positive associations to polysensitization. Five allergens p-phenylenediamine, neomycin...

  7. Growth performance and some haematological changes associated ...

    African Journals Online (AJOL)

    day feeding trial to evaluate growth performance and some haematological changes associated with yam peel meal inclusions in finisher diet of broiler chicks in Ghana. The birds were separated into four treatment groups (each group consisting ...

  8. Mean associative multiplicities in deep inelastic processes

    International Nuclear Information System (INIS)

    Dzhaparidze, G.Sh.; Kiselev, A.V.; Petrov, V.A.

    1981-01-01

    The associative hadron multiplicities in deep inelastic and Drell--Yan processes are studied. In particular the mean multiplicities in different hard processes in QCD are found to be determined by the mean multiplicity in parton jet [ru

  9. National Association of Area Agencies on Aging

    Science.gov (United States)

    National Association of Area Agencies on Aging Search Member Login Forgot Password? Menu ABOUT n4a Mission, Vision & Work AAAs & Title VI Aging Programs Membership Board of Directors Staff Contact ...

  10. Association of Cardiometabolic Multimorbidity With Mortality

    DEFF Research Database (Denmark)

    Di Angelantonio, Emanuele; Kaptoge, Stephen; Wormser, David

    2015-01-01

    IMPORTANCE: The prevalence of cardiometabolic multimorbidity is increasing. OBJECTIVE: To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. DESIGN, SETTING, AND PARTICIPANTS: Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using i...

  11. Acute dysautonomia associated with Hodgkin's disease

    NARCIS (Netherlands)

    van Lieshout, J. J.; Wieling, W.; van Montfrans, G. A.; Settels, J. J.; Speelman, J. D.; Endert, E.; Karemaker, J. M.

    1986-01-01

    A patient is described with acute dysautonomia associated with Hodgkin's disease. Testing of cardiovascular reflex control showed that this patient had a rare manifestation of autonomic cardiovascular neuropathy, namely intact parasympathetic heart rate control in combination with a sympathetic

  12. Factors associated with colonization of Streptococcus pneumoniae ...

    African Journals Online (AJOL)

    -fives attending clinic in Mwanza City, Tanzania. ... Number of children at home, positive HIV status and someone smoking showed association with S. pneumoniae carriage but the differences were not statistically significant. The resistance ...

  13. Association Between Insecure Attachment and ADHD

    DEFF Research Database (Denmark)

    Storebo, Ole Jakob; Darling Rasmussen, Pernille; Simonsen, Erik

    2016-01-01

    Objective: Psychological theories have postulated an association between insecure attachment and ADHD. The objective of this study is to investigate possible association between insecure attachment and ADHD in children and adults. Method: Review of literature was performed using the Psyc......INFO, Medline, and EMBASE databases. Results: Twenty-nine studies were included in the review. Overall, the studies showed that parental attachment problems and environmental mediating factors were significantly associated with childhood ADHD. Adults with ADHD had a much higher incidence of insecure attachment...... styles than reported in the general population. Conclusion: There seems to be a clear association between ADHD and insecure attachment. It is likely that early intervention in the form of parent training and pharmacological treatment may prevent development of attachment problems. But such studies have...

  14. Gyrokinetic Magnetohydrodynamics and the Associated Equilibrium

    Science.gov (United States)

    Lee, W. W.; Hudson, S. R.; Ma, C. H.

    2017-10-01

    A proposed scheme for the calculations of gyrokinetic MHD and its associated equilibrium is discussed related a recent paper on the subject. The scheme is based on the time-dependent gyrokinetic vorticity equation and parallel Ohm's law, as well as the associated gyrokinetic Ampere's law. This set of equations, in terms of the electrostatic potential, ϕ, and the vector potential, ϕ , supports both spatially varying perpendicular and parallel pressure gradients and their associated currents. The MHD equilibrium can be reached when ϕ -> 0 and A becomes constant in time, which, in turn, gives ∇ . (J|| +J⊥) = 0 and the associated magnetic islands. Examples in simple cylindrical geometry will be given. The present work is partially supported by US DoE Grant DE-AC02-09CH11466.

  15. Associations between depressive symptoms and insulin resistance

    DEFF Research Database (Denmark)

    Adriaanse, M C; Dekker, J M; Nijpels, G

    2006-01-01

    AIMS/HYPOTHESIS: The association between depression and insulin resistance has been investigated in only a few studies, with contradictory results reported. The aim of this study was to determine whether the association between symptoms of depression and insulin resistance varies across glucose...... established type 2 diabetes mellitus. Main outcome measures were insulin resistance defined by the homeostasis model assessment for insulin resistance (HOMA-IR) and symptoms of depression using the Centre for Epidemiologic Studies Depression Scale (CES-D). RESULTS: In the total sample, we found a weak.......942). The association between depressive symptoms and insulin resistance was similar for men and women. CONCLUSIONS/INTERPRETATION: We found only weak associations between depressive symptoms and insulin resistance, which did not differ among different glucose metabolism subgroups or between men and women....

  16. Codominant scoring of AFLP in association panels

    NARCIS (Netherlands)

    Gort, G.; Eeuwijk, van F.A.

    2010-01-01

    A study on the codominant scoring of AFLP markers in association panels without prior knowledge on genotype probabilities is described. Bands are scored codominantly by fitting normal mixture models to band intensities, illustrating and optimizing existing methodology, which employs the

  17. Chiari I malformation associated with turner syndrome

    Directory of Open Access Journals (Sweden)

    Kamble Jayaprakash Harsha

    2017-01-01

    Full Text Available Turner syndrome (TS is a rare genetic disease due to the absence of one X chromosome. Patients with TS have more subtle neurological/neuropsychiatric problems, while headache is an uncommon clinical presentation which needs attention. We report a 12-year-old child presenting with typical cough headache. Her magnetic resonance imaging revealed Chiari I malformation associated with TS. To the best of our knowledge, Chiari I malformation associated with TS is not described in literature. We report the first case of TS associated with Chiari I malformation. Interestingly, Chiari I malformation is also associated with Noonan's syndrome, which is a close morphological mimicker of TS, raising the possibility of sharing similar pathogenesis in both conditions.

  18. Costs Associated With Propane Vehicle Fueling Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.; Gonzales, J.

    2014-08-01

    This document is designed to help fleets understand the cost factors associated with propane vehicle fueling infrastructure. It provides an overview of the equipment and processes necessary to develop a propane fueling station and offers estimated cost ranges.

  19. Costs Associated With Propane Vehicle Fueling Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.; Gonzales, J.

    2014-08-05

    This document is designed to help fleets understand the cost factors associated with propane vehicle fueling infrastructure. It provides an overview of the equipment and processes necessary to develop a propane fueling station and offers estimated cost ranges.

  20. Anaerobic microbial associations degrading aminoaromatic acids

    NARCIS (Netherlands)

    Kotova, I.; Savelieva, O.; Dyakonova, A.T.; Sklyar, V.; Kalyushnyi, S.V.; Stams, A.J.M.; Netrusov, A.

    2005-01-01

    Anaerobic microbial associations have been isolated that degrade aminoaromatic acids to methane and carbon dioxide at high rates. Significant differences between the morphological, cytological, and physiological traits of cultures isolated from samples of adapted and unadapted sludge are shown. The

  1. Experience with Vincristine - Associated Neurotoxicity | Othieno ...

    African Journals Online (AJOL)

    associated neurotoxicity. Design: A retrospective case series study. Setting: Burlingham Oncology Clinic, Nairobi. Subjects: Thirty-eight patients treated for various neoplasms with vincristine containing chemotherapeutic regimens. Main outcome ...

  2. Awake, Offline Processing during Associative Learning.

    Science.gov (United States)

    Bursley, James K; Nestor, Adrian; Tarr, Michael J; Creswell, J David

    2016-01-01

    Offline processing has been shown to strengthen memory traces and enhance learning in the absence of conscious rehearsal or awareness. Here we evaluate whether a brief, two-minute offline processing period can boost associative learning and test a memory reactivation account for these offline processing effects. After encoding paired associates, subjects either completed a distractor task for two minutes or were immediately tested for memory of the pairs in a counterbalanced, within-subjects functional magnetic resonance imaging study. Results showed that brief, awake, offline processing improves memory for associate pairs. Moreover, multi-voxel pattern analysis of the neuroimaging data suggested reactivation of encoded memory representations in dorsolateral prefrontal cortex during offline processing. These results signify the first demonstration of awake, active, offline enhancement of associative memory and suggest that such enhancement is accompanied by the offline reactivation of encoded memory representations.

  3. Awake, Offline Processing during Associative Learning.

    Directory of Open Access Journals (Sweden)

    James K Bursley

    Full Text Available Offline processing has been shown to strengthen memory traces and enhance learning in the absence of conscious rehearsal or awareness. Here we evaluate whether a brief, two-minute offline processing period can boost associative learning and test a memory reactivation account for these offline processing effects. After encoding paired associates, subjects either completed a distractor task for two minutes or were immediately tested for memory of the pairs in a counterbalanced, within-subjects functional magnetic resonance imaging study. Results showed that brief, awake, offline processing improves memory for associate pairs. Moreover, multi-voxel pattern analysis of the neuroimaging data suggested reactivation of encoded memory representations in dorsolateral prefrontal cortex during offline processing. These results signify the first demonstration of awake, active, offline enhancement of associative memory and suggest that such enhancement is accompanied by the offline reactivation of encoded memory representations.

  4. Novel genetic loci associated with hippocampal volume

    OpenAIRE

    Hibar, Derrek P.; Adams, Hieab H. H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteria, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivieres, Sylvane; Vernooij, Meike W.; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf

    2017-01-01

    International audience; The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal ...

  5. A Case of Melanoma Associated Leukoderma

    Directory of Open Access Journals (Sweden)

    Özer Arıcan

    2010-06-01

    Full Text Available Melanoma associated leukoderma is a rare disease characterized by hypopigmented or depigmented macules, which are usualy localized at distant sites from the primary malignant melonoma. Immunologic response to abnormal melanocytes is thought to be responsible for the physiopathology of the disease. A 34-year- old male patient with a facially localized melanoma associated leukoderma is presented and the clinical features, pathogenesis, differential diagnosis, treatment and follow-up of the disease are discussed with the recent literature.

  6. Extension of UNIFAC to associating systems

    OpenAIRE

    Foco, Gloria; Ferreira, Olga; Brignole, Esteban A.; Bottini, Susana B.

    2001-01-01

    An extended UNIFAC group contribution model for the prediction of activity coefficients in associating mixtures was presented recently (Mengarelli et al.,1999). In the present work the model is applied to solutions containing alcohols, water, carboxylic acids and inert components. The residual UNIFAC local composition term is re-parameterized in order to take into account only dispersive forces between associating and inert functional groups. Good representation of vapor-liquid and liqu...

  7. Genetic Variants Associated with Circulating Parathyroid Hormone.

    Science.gov (United States)

    Robinson-Cohen, Cassianne; Lutsey, Pamela L; Kleber, Marcus E; Nielson, Carrie M; Mitchell, Braxton D; Bis, Joshua C; Eny, Karen M; Portas, Laura; Eriksson, Joel; Lorentzon, Mattias; Koller, Daniel L; Milaneschi, Yuri; Teumer, Alexander; Pilz, Stefan; Nethander, Maria; Selvin, Elizabeth; Tang, Weihong; Weng, Lu-Chen; Wong, Hoi Suen; Lai, Dongbing; Peacock, Munro; Hannemann, Anke; Völker, Uwe; Homuth, Georg; Nauk, Matthias; Murgia, Federico; Pattee, Jack W; Orwoll, Eric; Zmuda, Joseph M; Riancho, Jose Antonio; Wolf, Myles; Williams, Frances; Penninx, Brenda; Econs, Michael J; Ryan, Kathleen A; Ohlsson, Claes; Paterson, Andrew D; Psaty, Bruce M; Siscovick, David S; Rotter, Jerome I; Pirastu, Mario; Streeten, Elizabeth; März, Winfried; Fox, Caroline; Coresh, Josef; Wallaschofski, Henri; Pankow, James S; de Boer, Ian H; Kestenbaum, Bryan

    2017-05-01

    Parathyroid hormone (PTH) is a primary calcium regulatory hormone. Elevated serum PTH concentrations in primary and secondary hyperparathyroidism have been associated with bone disease, hypertension, and in some studies, cardiovascular mortality. Genetic causes of variation in circulating PTH concentrations are incompletely understood. We performed a genome-wide association study of serum PTH concentrations among 29,155 participants of European ancestry from 13 cohort studies ( n =22,653 and n =6502 in discovery and replication analyses, respectively). We evaluated the association of single nucleotide polymorphisms (SNPs) with natural log-transformed PTH concentration adjusted for age, sex, season, study site, and principal components of ancestry. We discovered associations of SNPs from five independent regions with serum PTH concentration, including the strongest association with rs6127099 upstream of CYP24A1 ( P =4.2 × 10 -53 ), a gene that encodes the primary catabolic enzyme for 1,25-dihydroxyvitamin D and 25-dihydroxyvitamin D. Each additional copy of the minor allele at this SNP associated with 7% higher serum PTH concentration. The other SNPs associated with serum PTH concentration included rs4074995 within RGS14 ( P =6.6 × 10 -17 ), rs219779 adjacent to CLDN14 ( P =3.5 × 10 -16 ), rs4443100 near RTDR1 ( P =8.7 × 10 -9 ), and rs73186030 near CASR ( P =4.8 × 10 -8 ). Of these five SNPs, rs6127099, rs4074995, and rs219779 replicated. Thus, common genetic variants located near genes involved in vitamin D metabolism and calcium and renal phosphate transport associated with differences in circulating PTH concentrations. Future studies could identify the causal variants at these loci, and the clinical and functional relevance of these variants should be pursued. Copyright © 2017 by the American Society of Nephrology.

  8. Auto-associative nanoelectronic neural network

    Energy Technology Data Exchange (ETDEWEB)

    Nogueira, C. P. S. M.; Guimarães, J. G. [Departamento de Engenharia Elétrica - Laboratório de Dispositivos e Circuito Integrado, Universidade de Brasília, CP 4386, CEP 70904-970 Brasília DF (Brazil)

    2014-05-15

    In this paper, an auto-associative neural network using single-electron tunneling (SET) devices is proposed and simulated at low temperature. The nanoelectronic auto-associative network is able to converge to a stable state, previously stored during training. The recognition of the pattern involves decreasing the energy of the input state until it achieves a point of local minimum energy, which corresponds to one of the stored patterns.

  9. Ontology Learning - Suggesting Associations from Text

    OpenAIRE

    Kvarv, Gøran Sveia

    2007-01-01

    In many applications, large-scale ontologies have to be constructed and maintained. A manual construction of an ontology is a time consuming and resource demanding process, often involving some domain experts. It would therefore be beneficial to support this process with tools that automates the construction of an ontology. This master thesis has examined the use of association rules for suggesting associations between words in text. In ontology learning, concepts are often extracted from d...

  10. Auto-associative nanoelectronic neural network

    International Nuclear Information System (INIS)

    Nogueira, C. P. S. M.; Guimarães, J. G.

    2014-01-01

    In this paper, an auto-associative neural network using single-electron tunneling (SET) devices is proposed and simulated at low temperature. The nanoelectronic auto-associative network is able to converge to a stable state, previously stored during training. The recognition of the pattern involves decreasing the energy of the input state until it achieves a point of local minimum energy, which corresponds to one of the stored patterns

  11. Terminal hemimyelocystocele associated with Chiari II malformation

    Directory of Open Access Journals (Sweden)

    Umamaheswara Reddy V.

    2014-06-01

    Full Text Available Terminal myelocystocele (TMC results from failure of embryonic CSF to drain outside the neural tube creating CSF reservoir within a dorsal meningocele. Association of Chiari II malformation with diastematomyelia and myelocystocele is extremely rare. Myelocystoceles do not have neural tissue so they have good prognosis after treatment, however when associated with hydromelia and Chiari malformation they present with neurological deficits. We present details of a 2 year old female who presented to us with this rare anomaly.

  12. ANCA-associated vasculitis and malignancy

    DEFF Research Database (Denmark)

    Mahr, Alfred; Heijl, Caroline; Le Guenno, Guillaume

    2013-01-01

    In this review, we summarise the current understanding of the potential link between cancer and anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (Wegener's; GPA) and microscopic polyangiitis (MPA). As is true for many autoimmune or infla......In this review, we summarise the current understanding of the potential link between cancer and anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (Wegener's; GPA) and microscopic polyangiitis (MPA). As is true for many autoimmune...

  13. Omphalocele and gastroschisis and associated malformations.

    Science.gov (United States)

    Stoll, Claude; Alembik, Yves; Dott, Beatrice; Roth, Marie-Paule

    2008-05-15

    The etiology of gastroschisis and omphalocele is unclear and their pathogenesis is controversial. Because previous reports have inconsistently noted the type and frequency of malformations associated with omphalocele and gastroschisis, we assessed these associated malformations ascertained between 1979 and 2003 in 334,262 consecutive births. Of the 86 patients with omphalocele, 64 (74.4%) had associated malformations. These included patients with chromosomal abnormalities (25, 29.0%); non-chromosomal syndromes including Beckwith-Wiedemann syndrome, Goltz syndrome, Marshall-Smith syndrome, Meckel-Gruber syndrome, Oto-palato-digital type II syndrome, CHARGE syndrome, and fetal valproate syndrome; malformation sequences, including ectopia cordis, body stalk anomaly, exstrophy of bladder, exstrophy of cloaca, and OEIS (Omphalocele, Exstrophy of bladder, Imperforate anus, Spinal defect); malformation complexes including Pentalogy of Cantrell, and non-syndromic multiple congenital anomalies (MCA) (26, 30.2%). Malformations of the musculoskeletal system (31, 23.5%), urogenital system (27, 20.4%), cardiovascular system (20, 15.1%), and central nervous system (12, 9.1%) were the most common other congenital malformations in patients with omphalocele and non-syndromic MCA. Of the 60 patients with gastroschisis, 10 (16.6%) had associated malformations. In contrast to omphalocele, gastroschisis was rarely associated with a complex pattern of malformation, that is, one each (1.7%) with a chromosomal abnormality (trisomy 21), sequence (amyoplasia congenita), unspecified dwarfism, and 7 (11.7%) with MCA. We observed a striking difference in the prevalence of total malformations (74.4% vs. 16.6%, P < 0.001) and specific patterns of malformations associated with omphalocele and gastroschisis which emphasizes the need to evaluate all patients with omphalocele and gastroschisis for possible associated malformations. Malformation surveillance programs should be aware that the

  14. Associated malformations in patients with anorectal anomalies.

    Science.gov (United States)

    Stoll, C; Alembik, Y; Dott, B; Roth, M P

    2007-01-01

    Patients with congenital anorectal malformations (ARM) often have other associated congenital defects. The reported incidence and the types of associated malformations vary between different studies. The purpose of this investigation was to assess the prevalences at birth of associated malformations in patients of a geographically defined population with ARM which were collected between 1979 and 2003 in 334, 262 consecutive births. Of the 174 patients with ARM during the study period, 49.4% had associated malformations. Patients with associated malformations were further classified into groups with nonsyndromic multiple congenital anomalies; chromosomal abnormalities; nonchromosomal syndromes including Townes-Brocks, Walker-Warburg, Ivemark, Fetal alcohol, Klippel-Feil, Pallister-Hall, Facio-auriculo-vertebral spectrum, deletion 22q11.2; sequences, including OEIS, Pierre Robin and sirenomelia; and associations including VATER and MURCS. Malformations of the urogenital system (81.1%) and of the skeletal system (45.5%) were the most common other congenital anomalies occurring with ARM in multiply malformed patients without recognized entities, followed by malformations of the cardiovascular system, the digestive system, and the central nervous system. Weight, length, and head circumference of children with ARM and multiple associated malformations were lower than in controls, as was the weight of the placenta. Prenatal detection by fetal ultrasonographic examination was rarely made in isolated ARM. However, even in multiple associated malformations, prenatal detection by fetal ultrasonographic examination had a low sensitivity, 36%. In conclusion the overall prevalence of malformations, which was close to 1 in two infants, emphasizes the need for a thorough investigation of patients with ARM. A routine screening for other malformations may be considered in patients with ARM, and genetic counseling seems warranted in most of these complicated cases.

  15. Bayesian Graphical Models for Genomewide Association Studies

    OpenAIRE

    Verzilli, Claudio J.; Stallard, Nigel; Whittaker, John C.

    2006-01-01

    As the extent of human genetic variation becomes more fully characterized, the research community is faced with the challenging task of using this information to dissect the heritable components of complex traits. Genomewide association studies offer great promise in this respect, but their analysis poses formidable difficulties. In this article, we describe a computationally efficient approach to mining genotype-phenotype associations that scales to the size of the data sets currently being ...

  16. Retinal Detachment Associated With Atopic Dermatitis.

    Science.gov (United States)

    Kothari, Nikisha; Young, Ryan C; Read, Sarah P; Tutiven, Jacqueline; Perez, Victor L; Flynn, Harry W; Berrocal, Audina M

    2017-06-01

    Ocular manifestations related to atopic dermatitis include keratoconus, keratoconjunctivitis, cataract, and retinal detachment. The authors report three cases of retinal detachment associated with atopic dermatitis. Although the pathogenesis is poorly understood, chronic blunt trauma may play a role in the development of retinal detachment. In addition, retinal detachments associated with atopic dermatitis may have lower rates of successful retinal detachment repair. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:513-517.]. Copyright 2017, SLACK Incorporated.

  17. Persistent insomnia is associated with mortality risk.

    Science.gov (United States)

    Parthasarathy, Sairam; Vasquez, Monica M; Halonen, Marilyn; Bootzin, Richard; Quan, Stuart F; Martinez, Fernando D; Guerra, Stefano

    2015-03-01

    Insomnia has been associated with mortality risk, but whether this association is different in subjects with persistent vs intermittent insomnia is unclear. Additionally, the role of systemic inflammation in such an association is unknown. We used data from a community-based cohort to determine whether persistent or intermittent insomnia, defined based on persistence of symptoms over a 6-year period, was associated with death during the following 20 years of follow-up. We also determined whether changes in serum C-reactive protein (CRP) levels measured over 2 decades between study initiation and insomnia determination were different for the persistent, intermittent, and never insomnia groups. The results were adjusted for confounders such as age, sex, body mass index, smoking, physical activity, alcohol, and sedatives. Of the 1409 adult participants, 249 (18%) had intermittent and 128 (9%) had persistent insomnia. During a 20-year follow-up period, 318 participants died (118 due to cardiopulmonary disease). In adjusted Cox proportional-hazards models, participants with persistent insomnia (adjusted hazards ratio [HR] 1.58; 95% confidence interval [CI], 1.02-2.45) but not intermittent insomnia (HR 1.22; 95% CI, 0.86-1.74) were more likely to die than participants without insomnia. Serum CRP levels were higher and increased at a steeper rate in subjects with persistent insomnia as compared with intermittent (P = .04) or never (P = .004) insomnia. Although CRP levels were themselves associated with increased mortality (adjusted HR 1.36; 95% CI, 1.01-1.82; P = .04), adjustment for CRP levels did not notably change the association between persistent insomnia and mortality. In a population-based cohort, persistent, and not intermittent, insomnia was associated with increased risk for all-cause and cardiopulmonary mortality and was associated with a steeper increase in inflammation. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Secondary Cutaneous Amyloidosis Associated with Mycosis Fungoides

    Science.gov (United States)

    2018-02-16

    and has been reported with PUVA use. To date, there are three reported cases of secondary localized cutaneous amyloidosis associated with mycosis...Secondary localized cutaneous amyloidosis is often not clinically apparent , but may be seen histologically. It is associated with several skin tumors...fungoides prior to any treatment. We present a case of a 39-year-old female who presented to the dermatology clinic for evaluation of facial acne

  19. Trinary Associative Memory Would Recognize Machine Parts

    Science.gov (United States)

    Liu, Hua-Kuang; Awwal, Abdul Ahad S.; Karim, Mohammad A.

    1991-01-01

    Trinary associative memory combines merits and overcomes major deficiencies of unipolar and bipolar logics by combining them in three-valued logic that reverts to unipolar or bipolar binary selectively, as needed to perform specific tasks. Advantage of associative memory: one obtains access to all parts of it simultaneously on basis of content, rather than address, of data. Consequently, used to exploit fully parallelism and speed of optical computing.

  20. Two genetic loci associated with ankle injury

    OpenAIRE

    Kim, Stuart K.; Kleimeyer, John P.; Ahmed, Marwa A.; Avins, Andrew L.; Fredericson, Michael; Dragoo, Jason L.; Ioannidis, John P. A.

    2017-01-01

    Ankle injuries, including sprains, strains and other joint derangements and instability, are common, especially for athletes involved in indoor court or jumping sports. Identifying genetic loci associated with these ankle injuries could shed light on their etiologies. A genome-wide association screen was performed using publicly available data from the Research Program in Genes, Environment and Health (RPGEH) including 1,694 cases of ankle injury and 97,646 controls. An indel (chr21:47156779:...

  1. Toxic metabolic syndrome associated with HAART

    DEFF Research Database (Denmark)

    Haugaard, Steen B

    2006-01-01

    (HAART) may encounter the HIV-associated lipodystrophy syndrome (HALS), which attenuates patient compliance to this treatment. HALS is characterised by impaired glucose and lipid metabolism and other risk factors for cardiovascular disease. This review depicts the metabolic abnormalities associated...... with HAART by describing the key cell and organ systems that are involved, emphasising the role of insulin resistance. An opinion on the remedies available to treat the metabolic abnormalities and phenotype of HALS is provided....

  2. Association and Centrality in Criminal Networks

    DEFF Research Database (Denmark)

    Petersen, Rasmus Rosenqvist

    Network-based techniques are widely used in criminal investigations because patterns of association are actionable and understandable. Existing network models with nodes as first class entities and their related measures (e.g., social networks and centrality measures) are unable to capture and an...... three of these associations and extend and test two centrality measures using CrimeFighter Investigator, a novel tool for criminal network investigation. Our findings show that the extended centrality measures offer new insights into criminal networks....

  3. Suicide and Lyme and associated diseases.

    Science.gov (United States)

    Bransfield, Robert C

    2017-01-01

    The aim of this paper is to investigate the association between suicide and Lyme and associated diseases (LAD). No journal article has previously performed a comprehensive assessment of this subject. Multiple case reports and other references demonstrate a causal association between suicidal risk and LAD. Suicide risk is greater in outdoor workers and veterans, both with greater LAD exposure. Multiple studies demonstrate many infections and the associated proinflammatory cytokines, inflammatory-mediated metabolic changes, and quinolinic acid and glutamate changes alter neural circuits which increase suicidality. A similar pathophysiology occurs in LAD. A retrospective chart review and epidemiological calculations were performed. LAD contributed to suicidality, and sometimes homicidality, in individuals who were not suicidal before infection. A higher level of risk to self and others is associated with multiple symptoms developing after acquiring LAD, in particular, explosive anger, intrusive images, sudden mood swings, paranoia, dissociative episodes, hallucinations, disinhibition, panic disorder, rapid cycling bipolar, depersonalization, social anxiety disorder, substance abuse, hypervigilance, generalized anxiety disorder, genital-urinary symptoms, chronic pain, anhedonia, depression, low frustration tolerance, and posttraumatic stress disorder. Negative attitudes about LAD from family, friends, doctors, and the health care system may also contribute to suicide risk. By indirect calculations, it is estimated there are possibly over 1,200 LAD suicides in the US per year. Suicidality seen in LAD contributes to causing a significant number of previously unexplained suicides and is associated with immune-mediated and metabolic changes resulting in psychiatric and other symptoms which are possibly intensified by negative attitudes about LAD from others. Some LAD suicides are associated with being overwhelmed by multiple debilitating symptoms, and others are impulsive

  4. Alopecia Areata Associated with Localized Vitiligo

    Directory of Open Access Journals (Sweden)

    Shankarling D. Kuchabal

    2010-03-01

    Full Text Available Alopecia areata is a common cause of noncicatricial alopecia that occurs in a patchy, confluent or diffuse pattern. It may occur as a single, self-limiting episode or may recur at varying intervals over many years. The association of alopecia areata with localized vitiligo has not been reported. The association of alopecia areata with localized vitiligo in the same patient is documented here; it is the first of its kind.

  5. Cannabis intake and intussusception: an accidental association?

    Directory of Open Access Journals (Sweden)

    Alberto Fernández-Atutxa

    Full Text Available Most intussusception cases in adults have an organic cause and their treatment is surgical. In some cases, there is no injury associated with intussusception and we can opt for conservative management. In our clinical practice we have shown the presence of intussusceptions in the absence of structural damage associated with chronic cannabis with a good course after conservative management. We describe three cases of recurrent intussusception in cannabis users, suggesting a relationship between cannabis use and the incidence of intussusception.

  6. Associations between B Vitamins and Parkinson's Disease.

    Science.gov (United States)

    Shen, Liang

    2015-08-27

    B vitamins may correlate with Parkinson's disease (PD) through regulating homocysteine level. However, there is no comprehensive assessment on the associations between PD and B vitamins. The present study was designed to perform a meta-analytic assessment of the associations between folate, vitamin B6, and vitamin B12 and PD, including the status of B vitamins in PD patients compared with controls, and associations of dietary intakes of B vitamins and risk of PD. A literature search using Medline database obtained 10 eligible studies included in the meta-analyses. Stata 12.0 statistical software was used to perform the meta-analysis. Pooled data revealed that there was no obvious difference in folate level between PD patients and healthy controls, and PD patients had lower level of vitamin B12 than controls. Available data suggested that higher dietary intake of vitamin B6 was associated with a decreased risk of PD (odds ratio (OR) = 0.65, 95% confidence intervals (CI) = (0.30, 1.01)), while no significant association was observed for dietary intake of folate and vitamin B12 and risk of PD. PD patients had lower level of vitamin B12 and similar level of folate compared with controls. Dietary intake of vitamin B6 exhibited preventive effect of developing PD based on the available data. As the number of included studies is limited, more studies are needed to confirm the findings and elucidate the underpinning underlying these associations.

  7. [Factors associated with mortality in cryptococcal meningitis].

    Science.gov (United States)

    Wu, Ji-qin; Xu, Bin; Ou, Xue-ting; Zhu, Li-ping; Weng, Xin-hua

    2010-01-05

    To investigate factors associated with mortality in non-AIDS patients with cryptococcal meningitis. We retrospectively reviewed 154 cases of non-HIV cryptococcal meningitis in a tertiary care hospital in China, from 1997 through 2007. The 1-year attributable mortality was 19.6% (28/143), and overall mortality was 28.7% (41/143). Advanced age (> or = 60 years), delay in diagnosis (> 4 months), hematologic malignancy, solid malignancy, altered mental status (coma, seizure, herniation), and CSF drainage or shunting were factors associated with increased death; factors associated with increased survival were amphotericin B based initial therapy and flucytosine containing therapy. In multivariate analysis, age > or = 60 years, the time from symptom onset to diagnosis > 4 months, coma, cerebral herniation, and non-amphotericin B based initial therapy were independently associated with increased overall mortality; factors independently associated with cause-specific mortality were time from symptom onset to diagnosis > 4 months, cerebral herniation and non-amphotericin B based initial therapy. A variety of factors were associated with mortality in non-AIDS cryptococcal meningitis. Amphotericin B based initial treatment was independently correlated to improved 1-year survival.

  8. Naturally Biased Associations Between Music and Poetry.

    Science.gov (United States)

    Albertazzi, Liliana; Canal, Luisa; Micciolo, Rocco; Ferrari, Fulvio; Sitta, Sebastiano; Hachen, Iacopo

    2017-02-01

    The study analyzes the existence of naturally biased associations in the general population between a series of musical selections and a series of quatrains. Differently from other studies in the field, the association is tested between complex stimuli involving literary texts, which increases the load of the semantic factors. The stimuli were eight quatrains taken from the same poem and eight musical clips taken from a classical musical version of the poem. The experiment was conducted in two phases. First, the participants were asked to rate 10 couples of opposite adjectives on a continuous bipolar scale when reading a quatrain or when listening to a musical clip; then they were asked to associate a given clip directly with the quatrains in decreasing order. The results showed the existence of significant associations between the semantics of the quatrains and the musical selections. They also confirmed the correspondences experienced by the composer when writing the musical version of the poem. Connotative dimensions such as rough or smooth, distressing or serene, turbid or clear, and gloomy or bright, characterizing both the semantic and the auditory stimuli, may have played a role in the associations. The results also shed light on the accomplishment of the two diverse methodologies adopted in the two different phases of the test. Finally, the role of specific musical components and their combinations is likely to have played an important role in the associations, an aspect that shall be addressed in further studies.

  9. Associating Symptom Phenotype and Genotype in Preeclampsia.

    Science.gov (United States)

    Founds, Sandra A; Tsigas, Eleni; Ren, Dianxu; Barmada, M Michael

    2018-03-01

    Preeclampsia is a complex genetic disorder with an incompletely understood pathogenesis. Its phenotype may be better elucidated by integrating symptoms. This study aimed to identify symptoms by gestational age and associations with novel preeclampsia candidate genes. Women with a history of preeclampsia recruited from The Preeclampsia Registry completed clinical/demographic, symptom surveys and provided medical records. DNA extracted from saliva was processed with multiplexed assays for eight single-nucleotide polymorphisms (SNPs) selected to tag candidate genes and/or located in symptom susceptibility regions. Groups with versus without symptoms were compared using χ 2 . Associations between SNPs and symptoms were analyzed as genotype categories and presence/absence of the variant allele. Logistic regression modeling was conducted with exploratory p = .05. In 114 participants, 113 reported at least 1 of the 18 symptoms. Symptoms varied by trimester. Nine symptoms were associated with seven SNPs. Visual disturbances were associated with three SNPs and nausea/vomiting with two SNPs. Modeling adjustment for maternal age and parity resulted in 15 associations between 9 symptoms and 8 SNPs. Medical records demonstrated 100% concordance with self-reported diagnosis and 48% concordance with reported severity. Findings indicated novel symptom-genotype associations in preeclampsia. The small sample was self-selected, but results support future studies including medical records review. When validated, these results may lead to holistic phenotyping of women to characterize subsets of preeclampsia. This approach may optimize health in pregnancy and later life for mothers and offspring through prediction, prevention, and precision nursing care.

  10. Associations of Systemic Diseases with Intermediate Uveitis.

    Science.gov (United States)

    Shoughy, Samir S; Kozak, Igor; Tabbara, Khalid F

    2016-01-01

    To determine the associations of systemic diseases with intermediate uveitis. The medical records of 50 consecutive cases with intermediate uveitis referred to The Eye Center in Riyadh, Saudi Arabia, were reviewed. Age- and sex-matched patients without uveitis served as controls. Patients had complete ophthalmic and medical examinations. There were 27 male and 23 female patients. Mean age was 29 years with a range of 5-62 years. Overall, 21 cases (42%) had systemic disorders associated with intermediate uveitis and 29 cases (58%) had no associated systemic disease. A total of 11 patients (22%) had asthma, 4 (8%) had multiple sclerosis, 3 (6%) had presumed ocular tuberculosis, 1 (2%) had inflammatory bowel disease, 1 (2%) had non-Hodgkin lymphoma and 1 (2%) had sarcoidosis. Evidence of systemic disease was found in 50 (5%) of the 1,000 control subjects. Bronchial asthma was found in 37 patients (3.7 %), multiple sclerosis in 9 patients (0.9%), inflammatory bowel disease in 3 patients (0.3%), and tuberculosis in 1 patient (0.1%). None of the control patients had sarcoidosis or lymphoma. There were statistically significant associations between intermediate uveitis and bronchial asthma (p = 0.0001), multiple sclerosis (p = 0.003) and tuberculosis (p = 0.0005). Bronchial asthma and multiple sclerosis were the most frequently encountered systemic diseases associated with intermediate uveitis in our patient population. Patients with intermediate uveitis should undergo careful history-taking and investigations to rule out associated systemic illness.

  11. Association between Snoring and Leukocyte Telomere Length.

    Science.gov (United States)

    Shin, Chol; Yun, Chang-Ho; Yoon, Dae Wui; Baik, Inkyung

    2016-04-01

    Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomere length (LTL) using PSG and a questionnaire. A cross-sectional PSG study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2010-2013. During the same period, questionnaire-based interviews, blood collection, and relative LTL assays were conducted. A total of 887 Korean men and women aged 50-79 y with an apnea-hypopnea index (AHI) snoring during sleep (% time spent snoring) assessed by PSG was inversely associated with LTL even after adjusting for potential risk factors and AHI. In the linear regression association between tertiles of percentage of time spent snoring and log-transformed LTL, coefficient estimates (P value) were -0.076 (snoring status determined using PSG and questionnaire information, both primary snorers and those with mild sleep apnea (5 ≤ AHI snoring may influence telomere attrition independent of sleep apnea. © 2016 Associated Professional Sleep Societies, LLC.

  12. Two genetic loci associated with ankle injury.

    Science.gov (United States)

    Kim, Stuart K; Kleimeyer, John P; Ahmed, Marwa A; Avins, Andrew L; Fredericson, Michael; Dragoo, Jason L; Ioannidis, John P A

    2017-01-01

    Ankle injuries, including sprains, strains and other joint derangements and instability, are common, especially for athletes involved in indoor court or jumping sports. Identifying genetic loci associated with these ankle injuries could shed light on their etiologies. A genome-wide association screen was performed using publicly available data from the Research Program in Genes, Environment and Health (RPGEH) including 1,694 cases of ankle injury and 97,646 controls. An indel (chr21:47156779:D) that lies close to a collagen gene, COL18A1, showed an association with ankle injury at genome-wide significance (p = 3.8x10-8; OR = 1.99; 95% CI = 1.75-2.23). A second DNA variant (rs13286037 on chromosome 9) that lies within an intron of the transcription factor gene NFIB showed an association that was nearly genome-wide significant (p = 5.1x10-8; OR = 1.63; 95% CI = 1.46-1.80). The ACTN3 R577X mutation was previously reported to show an association with acute ankle sprains, but did not show an association in this cohort. This study is the first genome-wide screen for ankle injury that yields insights regarding the genetic etiology of ankle injuries and provides DNA markers with the potential to inform athletes about their genetic risk for ankle injury.

  13. Two genetic loci associated with ankle injury.

    Directory of Open Access Journals (Sweden)

    Stuart K Kim

    Full Text Available Ankle injuries, including sprains, strains and other joint derangements and instability, are common, especially for athletes involved in indoor court or jumping sports. Identifying genetic loci associated with these ankle injuries could shed light on their etiologies. A genome-wide association screen was performed using publicly available data from the Research Program in Genes, Environment and Health (RPGEH including 1,694 cases of ankle injury and 97,646 controls. An indel (chr21:47156779:D that lies close to a collagen gene, COL18A1, showed an association with ankle injury at genome-wide significance (p = 3.8x10-8; OR = 1.99; 95% CI = 1.75-2.23. A second DNA variant (rs13286037 on chromosome 9 that lies within an intron of the transcription factor gene NFIB showed an association that was nearly genome-wide significant (p = 5.1x10-8; OR = 1.63; 95% CI = 1.46-1.80. The ACTN3 R577X mutation was previously reported to show an association with acute ankle sprains, but did not show an association in this cohort. This study is the first genome-wide screen for ankle injury that yields insights regarding the genetic etiology of ankle injuries and provides DNA markers with the potential to inform athletes about their genetic risk for ankle injury.

  14. An association account of false belief understanding.

    Science.gov (United States)

    De Bruin, L C; Newen, A

    2012-05-01

    The elicited-response false belief task has traditionally been considered as reliably indicating that children acquire an understanding of false belief around 4 years of age. However, recent investigations using spontaneous-response tasks suggest that false belief understanding emerges much earlier. This leads to a developmental paradox: if young infants already understand false belief, then why do they fail the elicited-response false belief task? We postulate two systems to account for the development of false belief understanding: an association module, which provides infants with the capacity to register congruent associations between agents and objects, and an operating system, which allows them to transform these associations into incongruent associations through a process of inhibition, selection and representation. The interaction between the association module and the operating system enables infants to register increasingly complex associations on the basis of another agent's movements, visual perspective and propositional attitudes. This allows us account for the full range of findings on false belief understanding. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Effect of Allopurinol on Cardiovascular Outcomes in Hyperuricemic Patients

    DEFF Research Database (Denmark)

    Larsen, Kasper Søltoft; Pottegård, Anton; Lindegaard, Hanne M

    2015-01-01

    BACKGROUND: Hyperuricemia and gout have been associated with increased cardiovascular risk. Allopurinol is an effective urate-lowering drug. Whether lowering of urate by allopurinol improves the cardiovascular risk in hyperuricemic patients remains to be established. OBJECTIVE: Our objective...... was to investigate the effect of allopurinol on cardiovascular outcomes in hyperuricemic patients in an observational setting. METHODS: We had access to a study population consisting of all patients from Funen County, Denmark with high urate levels (≥6 mg/dL) from 1992 to 2010. We linked 4 registries; all blood...... competing risk regression model, with respect to Antiplatelet Trialists' Collaboration composite outcome (myocardial infarction, stroke, or cardiovascular death) and all-cause mortality. RESULTS: Among 65,971 patients with hyperuricemia, we found 7127 patients on allopurinol treatment. In the propensity...

  16. Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema

    Science.gov (United States)

    Pare, Guillaume; Kubo, Michiaki; Byrd, James B.; McCarty, Catherine A.; Woodard-Grice, Alencia; Teo, Koon K.; Anand, Sonia S.; Zuvich, Rebecca L.; Bradford, Yuki; Ross, Stephanie; Nakamura, Yusuke; Ritchie, Marylyn; Brown, Nancy J.

    2013-01-01

    Objective The objective of this study was to identify genetic variants associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema. Participants and methods We carried out a genome-wide association study in 175 individuals with ACE inhibitor-associated angioedema and 489 ACE inhibitor-exposed controls from Nashville (Tennessee) and Marshfield (Wisconsin). We tested for replication in 19 cases and 57 controls who participated in Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET). Results There were no genome-wide significant associations of any single-nucleotide polymorphism (SNP) with angioedema. Sixteen SNPs in African Americans and 41 SNPs in European Americans were associated moderately with angioedema (Pangioedema in the Nashville/Marshfield sample and ONTARGET. In a candidate gene analysis, rs989692 in the gene encoding neprilysin (MME), an enzyme that degrades bradykinin and substance P, was significantly associated with angioedema in ONTARGET and Nashville/Marshfield African Americans. Conclusion Unlike other serious adverse drug effects, ACE inhibitor-associated angioedema is not associated with a variant with a large effect size. Variants in MME and genes involved in immune regulation may be associated with ACE inhibitor-associated angioedema. PMID:23838604

  17. Genetic determinants of cocaine-associated agranulocytosis.

    Science.gov (United States)

    Buxton, Jane A; Omura, John; Kuo, Margot; Ross, Colin; Tzemis, Despina; Purssell, Roy; Gardy, Jennifer; Carleton, Bruce

    2015-06-13

    Drug-induced agranulocytosis is a recognized adverse drug event associated with serious infectious complications. Levamisole is an antihelminthic and immunomodulator withdrawn from North American markets in 2005 after reports of agranulocytosis. Previous studies of levamisole, suggest that the human leukocyte antigen (HLA)-B27 confers a genetic predisposition to this adverse drug event. Since 2009, emergency room visits due to agranulocytosis in individuals consuming levamisole-adulterated crack-cocaine have increased. We performed a case-control study using a genotyping assay and novel gene chip to test the association between cocaine-associated agranulocytosis (CAA) and HLA-B27 and to identify pharmacokinetic and pharmacodynamic gene variants associated with the phenotype. Fifty-one CAA cases were identified through a provincial physician reporting system between 2008 and 2011. We examined eight of these cases and 26 matched controls. Genotyping revealed a significant association between HLA-B27 and CAA (odds ratio [OR] 9.2, 95% confidence interval [CI], 1.54-54.6). We also observed a similar association with the HLA-B27 tag single nucleotide polymorphism rs4349859 (OR 9.2, 95% CI 1.5-54.6) and rs13202464 (OR 6.7, 95% CI 1.1-41). Further associations were identified with variants in the ARBCC12 (OR 10.0, 95% CI 2.7-36.8) and CYP11A1 (OR 7.4, 95% CI 2.1-26.6) genes, while a novel protective association was observed with variants in the ARDB1 gene (OR 0.06, 95% CI 0.007-0.46). We confirmed the association of HLA-B27 with CAA and identified additional susceptibility variants. Health care providers should inform people who are identified as having CAA that it is genetically determined and can recur with continued cocaine use. The severity of infections and subsequent hospitalization, and the risk of recurrence may prompt health-promoting behaviour changes of the affected individuals. These genetic associations warrant the attention of public health and knowledge

  18. Associated anomalies in cases with esophageal atresia.

    Science.gov (United States)

    Stoll, Claude; Alembik, Yves; Dott, Beatrice; Roth, Marie-Paule

    2017-08-01

    Esophageal atresia (EA) is a common type of congenital anomaly. The etiology of esophageal atresia is unclear and its pathogenesis is controversial. Infants with esophageal atresia often have other non-EA associated congenital anomalies. The purpose of this investigation was to assess the prevalence and the types of these associated anomalies in a defined population. The associated anomalies in cases with EA were collected in all livebirths, stillbirths, and terminations of pregnancy during 29 years in 387,067 consecutive births in the area covered by our population-based registry of congenital malformations. Of the 116 cases with esophageal atresia, representing a prevalence of 2.99 per 10,000, 54 (46.6%) had associated anomalies. There were 9 (7.8%) cases with chromosomal abnormalities including 6 trisomies 18, and 20 (17.2%) nonchromosomal recognized dysmorphic conditions including 12 cases with VACTERL association and 2 cases with CHARGE syndrome. Twenty five (21.6%) of the cases had multiple congenital anomalies (MCA). Anomalies in the cardiovascular, the digestive, the urogenital, the musculoskeletal, and the central nervous systems were the most common other anomalies. The anomalies associated with esophageal atresia could be classified into a recognizable malformation syndrome or pattern in 29 out of 54 cases (53.7%). This study included special strengths: each affected child was examined by a geneticist, all elective terminations were ascertained, and the surveillance for anomalies was continued until 2 years of age. In conclusion the overall prevalence of associated anomalies, which was close to one in two cases, emphasizes the need for a thorough investigation of cases with EA. A routine screening for other anomalies may be considered in infants and in fetuses with EA. © 2017 Wiley Periodicals, Inc.

  19. Periodontal diseases and osteoporosis: association and mechanisms.

    Science.gov (United States)

    Wactawski-Wende, J

    2001-12-01

    There is increasing evidence that osteoporosis, and the underlying loss of bone mass characteristic of this disease, is associated with periodontal disease and tooth loss. Periodontitis has long been defined as an infection-mediated destruction of the alveolar bone and soft tissue attachment to the tooth, responsible for most tooth loss in adult populations. Current evidence including several prospective studies supports an association of osteoporosis with the onset and progression of periodontal disease in humans. The majority of studies have shown low bone mass to be independently associated with loss of alveolar crestal height and tooth loss. However studies that focus on the relation of clinical attachment loss and osteoporosis are less consistent. To date, the majority of studies on the relationship between periodontal disease and osteoporosis have been hindered by small sample sizes, limited control of other potential confounding factors, varying definitions of both periodontal disease and osteoporosis, and few prospective studies where the temporality of the association can be established. Potential mechanisms by which host factors may influence onset and progression of periodontal disease directly or indirectly include underlying low bone density in the oral cavity, bone loss as an inflammatory response to infection, genetic susceptibility, and shared exposure to risk factors. Systemic loss of bone density in osteoporosis, including that of the oral cavity, may provide a host system that is increasingly susceptible to infectious destruction of periodontal tissue. Studies have provided evidence that hormones, heredity, and other host factors influence periodontal disease incidence and severity. Both periodontal disease and osteoporosis are serious public-health concerns in the United States. Prevalence of both osteoporosis and tooth loss increase with advancing age in both women and men. Understanding the association between these common diseases and the

  20. Associative Processing Is Inherent in Scene Perception

    Science.gov (United States)

    Aminoff, Elissa M.; Tarr, Michael J.

    2015-01-01

    How are complex visual entities such as scenes represented in the human brain? More concretely, along what visual and semantic dimensions are scenes encoded in memory? One hypothesis is that global spatial properties provide a basis for categorizing the neural response patterns arising from scenes. In contrast, non-spatial properties, such as single objects, also account for variance in neural responses. The list of critical scene dimensions has continued to grow—sometimes in a contradictory manner—coming to encompass properties such as geometric layout, big/small, crowded/sparse, and three-dimensionality. We demonstrate that these dimensions may be better understood within the more general framework of associative properties. That is, across both the perceptual and semantic domains, features of scene representations are related to one another through learned associations. Critically, the components of such associations are consistent with the dimensions that are typically invoked to account for scene understanding and its neural bases. Using fMRI, we show that non-scene stimuli displaying novel associations across identities or locations recruit putatively scene-selective regions of the human brain (the parahippocampal/lingual region, the retrosplenial complex, and the transverse occipital sulcus/occipital place area). Moreover, we find that the voxel-wise neural patterns arising from these associations are significantly correlated with the neural patterns arising from everyday scenes providing critical evidence whether the same encoding principals underlie both types of processing. These neuroimaging results provide evidence for the hypothesis that the neural representation of scenes is better understood within the broader theoretical framework of associative processing. In addition, the results demonstrate a division of labor that arises across scene-selective regions when processing associations and scenes providing better understanding of the functional

  1. Señor presidente no creo en vos; señor policía no temo de voz. Represión estatal y paramilitar y prácticas juveniles en los barrios Alameda, Brisas, Anita y Almendros

    OpenAIRE

    Sastoque Espinosa, Víctor Angel

    2015-01-01

    El estudio sobre la juventud y su relación con prácticas realizadas en los espacios públicos, especialmente la calle, ha tenido un renovado interés durante las últimas décadas. Estos debates se han vuelto relevantes en cuanto que los jóvenes parecen ocupar un lugar primordial en las escenas cotidianas de violencia, en particular los jóvenes de sectores populares. A través de un proceso etnográfico de carácter sistemático y sostenido en el tiempo identifico y explico las distintas interaccione...

  2. Association between Positivity and Smoking Cessation

    Directory of Open Access Journals (Sweden)

    Maria Caterina Grassi

    2014-01-01

    Full Text Available The literature documents that personality characteristics are associated with healthy lifestyles, including smoking. Among positive traits, Positivity (POS, defined as a general disposition conducive to facing experience under a positive outlook has shown robust associations with psychological health. Thus, the present study investigated the extent to which POS is able to predict (i relapse after quitting smoking and (ii the desire to smoke again. All participants (481 had previously attended a Group Counselling Program (GCP for Smoking Cessation (from 2005 through 2010. They were contacted through telephone interview. Among participants, 244 were ex-smokers (age: years 56.3±10.08, 52% female and 237 were still-smokers (age: years 55.0±9.63; 63.5% female. The association of POS with “craving to smoke” levels was assessed with multivariate linear regression analysis while controlling also for important differences in personality such as conscientiousness and general self-efficacy, as well as for gender and age. Results showed that POS was significantly and negatively associated with smoking status and with craving to smoke. Among covariates (i.e., conscientiousness, generalized self-efficacy, gender was associated with smoking status and with craving to smoke. Altogether these findings corroborate the idea that POS plays a significant role in sustaining individuals' efforts to quit smoking.

  3. Environmental impacts associated with Project Rio Blanco

    International Nuclear Information System (INIS)

    Alldredge, A.W.; Whicker, F.W.; Hanson, W.C.

    Project Rio Blanco, an experiment involving deep underground detonation of three 30-kton nuclear explosives designed to stimulate natural gas flow in geologic formations of low permeability, was conducted in western Colorado on 17 May 1973. Environmental impacts associated with this experiment were divided into three categories: radiation, ground motion, and conventional physical activities. Radiation and ground motion are unique to this type experiment while conventional activities would be associated with any type of resource development. The objective of observations made at Rio Blanco was to qualitatively and, where possible, quantitatively ascertain environmental impacts associated with the project. Observations indicated that ground motion and conventional activities appeared to cause the greatest impacts. Ground motion impacts were most severe within 2.4 km of the emplacement well (EW) and were predominantly associated with steep ravine and stream banks and rocky cliffs. Following the detonation, flow and turbidity had increased in a small stream adjacent to the EW. Animals receiving deleterious impacts were those associated with stream banks, cliffs and burrows. No mortality or injury was observed in any large animals. (U.S.)

  4. Auditing Associative Relations across Two Knowledge Sources

    Science.gov (United States)

    Vizenor, Lowell T.; Bodenreider, Olivier; McCray, Alexa T.

    2009-01-01

    Objectives This paper proposes a novel semantic method for auditing associative relations in biomedical terminologies. We tested our methodology on two Unified Medical Language System (UMLS) knowledge sources. Methods We use the UMLS semantic groups as high-level representations of the domain and range of relationships in the Metathesaurus and in the Semantic Network. A mapping created between Metathesaurus relationships and Semantic Network relationships forms the basis for comparing the signatures of a given Metathesaurus relationship to the signatures of the semantic relationship to which it is mapped. The consistency of Metathesaurus relations is studied for each relationship. Results Of the 177 associative relationships in the Metathesaurus, 84 (48%) exhibit a high degree of consistency with the corresponding Semantic Network relationships. Overall, 63% of the 1.8M associative relations in the Metathesaurus are consistent with relations in the Semantic Network. Conclusion The semantics of associative relationships in biomedical terminologies should be defined explicitly by their developers. The Semantic Network would benefit from being extended with new relationships and with new relations for some existing relationships. The UMLS editing environment could take advantage of the correspondence established between relationships in the Metathesaurus and the Semantic Network. Finally, the auditing method also yielded useful information for refining the mapping of associative relationships between the two sources. PMID:19475724

  5. Is atopic dermatitis associated with obesity?

    DEFF Research Database (Denmark)

    Ali, Zarqa; Suppli Ulrik, Charlotte; Agner, Tove

    2018-01-01

    Obesity has been associated with atopic dermatitis (AD), however the results have been conflicting. Our aim was to provide an update on current knowledge from observational studies addressing the possible association between obesity and AD. Systematic literature review was performed by identifyin...... to confirm the association between AD and obesity and the possibility that weight control in childhood may help to mitigate or reverse AD symptoms. This article is protected by copyright. All rights reserved.......Obesity has been associated with atopic dermatitis (AD), however the results have been conflicting. Our aim was to provide an update on current knowledge from observational studies addressing the possible association between obesity and AD. Systematic literature review was performed by identifying...... studies addressing a possible link between AD and overweight/obesity from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guidelines. The quality of the included studies was assessed using the Newcastle...

  6. Dapsone-associated fixed drug eruption.

    Science.gov (United States)

    Garcia, Daniel; Cohen, Philip R

    2017-07-01

    Dapsone is a sulfone drug used to treat infectious conditions and also numerous dermatologic diseases. Fixed drug eruption is a distinctive adverse cutaneous reaction associated with the initial administration and subsequent delivery of a specific agent. Areas covered: The authors preformed a literature search using the following keywords: dapsone, fixed drug eruption, and adverse cutaneous drug reaction. Bibliographies were also reviewed for pertinent articles. The results were combed for relevant papers and reviewed. Articles pertaining to dapsone-associated fixed drug eruption were included. Expert commentary: The majority of cases of dapsone-associated fixed drug eruption in the literature come from Africa or India where there is a high prevalence of patients treated for leprosy. Characteristics of these cases are similar to fixed drug eruption described in the western literature, with differences in frequency of multiple versus solitary lesions. Dapsone-associated fixed drug eruption should be considered when reviewing the drug history of a patient with fixed drug eruption. In the case of darker pigmented individuals, multiple fixed drug eruption lesions may be more common. Multiple lesions may mimic Kaposi's sarcoma in human immunodeficiency virus positive patients. Dapsone-associated fixed drug eruption should be considered in the differential diagnosis of multiple hyperpigmented lesions.

  7. Genetic Variants Associated with Colorectal Adenoma Susceptibility.

    Directory of Open Access Journals (Sweden)

    Anna Abulí

    Full Text Available Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk.To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas.We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity.We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles.Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.

  8. FUNGAL ASSOCIATION WITH SESSILE MARINE INVERTEBRATES

    Directory of Open Access Journals (Sweden)

    Oded eYarden

    2014-05-01

    Full Text Available The presence and association of fungi with sessile marine animals such as coral and sponges has been well established, yet information on the extent of diversity of the associated fungi is still in its infancy. Culture- as well as metagenomic- and transcriptomic-based analyses have shown that fungal presence in association with these animals can be dynamic and can include core residents as well as shifts in fungal communities. Evidence for detrimental and beneficial interactions between fungi and their marine hosts is accumulating and current challenges include the elucidation of the chemical and cellular crosstalk between fungi and their associates within the holobionts. The ecological function of fungi in association with sessile marine animals is complex and is founded on a combination of factors such as fungal origin, host health, environmental conditions and the presence of other resident or invasive microorganisms in the host. Based on evidence from the much more studied terrestrial systems, the evaluation of marine animal-fungal symbioses under varying environmental conditions may well prove to be critical in predicting ecosystem response to global change, including effects on the health of sessile marine animals.

  9. Association Between Obesity and Migraine in Women.

    Science.gov (United States)

    Pavlovic, Jelena M; Vieira, Julio R; Lipton, Richard B; Bond, Dale S

    2017-08-25

    Migraine is a common and highly disabling condition that is particularly prevalent among women and especially women of reproductive age. The tremendous rise in adiposity in the Western world has led to an epidemic of obesity in women. The particular effects of obesity on women with migraine of various ages are the focus of this review. Conflicting findings from various studies with different approaches and populations have made challenging definitive conclusions about associations between migraine and obesity. While the association between obesity and migraine frequency has been consistently demonstrated and obesity is considered a risk factor for progression from episodic to chronic migraine, the association between obesity and migraine prevalence is still somewhat debated and appears to be dependent on gender and age, with the most consistent effects observed in women younger than 55 years of age. Association between migraine and obesity is most commonly observed in women of reproductive age. The multimodal changes associated with age and hormonal change in women likely play a role in this relationship, as obesity does not appear to be related to migraine in women over 55 years of age. Future studies focusing on the migraine-obesity relationship in women should examine the effects of age, endogenous hormonal state, and exogenous hormones on migraine and obesity.

  10. EXPLAINING THE ASSOCIATION BETWEEN INCARCERATION AND DIVORCE*

    Science.gov (United States)

    Siennick, Sonja E.; Stewart, Eric A.; Staff, Jeremy

    2014-01-01

    Recent studies have suggested that incarceration dramatically increases the odds of divorce, but we know little about the mechanisms that explain the association. This study uses prospective longitudinal data from a subset of married young adults in the National Longitudinal Study of Adolescent Health (N = 1,919) to examine whether incarceration is associated with divorce indirectly via low marital love, economic strain, relationship violence, and extramarital sex. The findings confirmed that incarcerations occurring during, but not before, a marriage were associated with an increased hazard of divorce. Incarcerations occurring during marriage also were associated with less marital love, more relationship violence, more economic strain, and greater odds of extramarital sex. Above-average levels of economic strain were visible among respondents observed preincarceration, but only respondents observed postincarceration showed less marital love, more relationship violence, and higher odds of extramarital sex than did respondents who were not incarcerated during marriage. These relationship problems explained approximately 40 percent of the association between incarceration and marital dissolution. These findings are consistent with theoretical predictions that a spouse’s incarceration alters the rewards and costs of the marriage and the relative attractiveness of alternative partners. PMID:25598544

  11. Association of Oxidative Stress with Psychiatric Disorders.

    Science.gov (United States)

    Hassan, Waseem; Noreen, Hamsa; Castro-Gomes, Vitor; Mohammadzai, Imdadullah; da Rocha, Joao Batista Teixeira; Landeira-Fernandez, J

    2016-01-01

    When concentrations of both reactive oxygen species and reactive nitrogen species exceed the antioxidative capability of an organism, the cells undergo oxidative impairment. Impairments in membrane integrity and lipid and protein oxidation, protein mutilation, DNA damage, and neuronal dysfunction are some of the fundamental consequences of oxidative stress. The purpose of this work was to review the associations between oxidative stress and psychological disorders. The search terms were the following: "oxidative stress and affective disorders," "free radicals and neurodegenerative disorders," "oxidative stress and psychological disorders," "oxidative stress, free radicals, and psychiatric disorders," and "association of oxidative stress." These search terms were used in conjunction with each of the diagnostic categories of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders and World Health Organization's International Statistical Classification of Diseases and Related Health Problems. Genetic, pharmacological, biochemical, and preclinical therapeutic studies, case reports, and clinical trials were selected to explore the molecular aspects of psychological disorders that are associated with oxidative stress. We identified a broad spectrum of 83 degenerative syndromes and psychiatric disorders that were associated with oxidative stress. The multi-dimensional information identified herein supports the role of oxidative stress in various psychiatric disorders. We discuss the results from the perspective of developing novel therapeutic interventions.

  12. Solid tumors associated with multiple endocrine neoplasias.

    Science.gov (United States)

    Almeida, Madson Q; Stratakis, Constantine A

    2010-11-01

    We present an update on molecular and clinical genetics of solid tumors associated with the various multiple endocrine neoplasias (MEN) syndromes. MEN type 1 (MEN1) describes the association of pituitary, parathyroid, and pancreatic islet cell tumors with a variety of many other lesions. MEN type 2 (MEN2) conditions represent at least four different syndromes that associate pheochromocytoma with medullary thyroid carcinoma, hyperparathyroidism, and a number of other manifestations. Other pheochromocytoma-associated syndromes include von Hippel-Lindau disease; neurofibromatosis 1; the recently defined paraganglioma syndromes type 1, 3, and 4; Carney-Stratakis syndrome; and the Carney triad. Carney-Stratakis syndrome is characterized by the association of paragangliomas and familial gastrointestinal stromal tumors. In the Carney triad, patients can manifest gastrointestinal stromal tumors, lung chondroma, paraganglioma, adrenal adenoma and pheochromocytoma, esophageal leiomyoma, and other conditions. The Carney complex is yet another form of MEN that is characterized by skin tumors and pigmented lesions, myxomas, schwannomas, and various endocrine neoplasias. Copyright © 2010 Elsevier Inc. All rights reserved.

  13. Cross-cultural color-odor associations.

    Directory of Open Access Journals (Sweden)

    Carmel A Levitan

    Full Text Available Colors and odors are associated; for instance, people typically match the smell of strawberries to the color pink or red. These associations are forms of crossmodal correspondences. Recently, there has been discussion about the extent to which these correspondences arise for structural reasons (i.e., an inherent mapping between color and odor, statistical reasons (i.e., covariance in experience, and/or semantically-mediated reasons (i.e., stemming from language. The present study probed this question by testing color-odor correspondences in 6 different cultural groups (Dutch, Netherlands-residing-Chinese, German, Malay, Malaysian-Chinese, and US residents, using the same set of 14 odors and asking participants to make congruent and incongruent color choices for each odor. We found consistent patterns in color choices for each odor within each culture, showing that participants were making non-random color-odor matches. We used representational dissimilarity analysis to probe for variations in the patterns of color-odor associations across cultures; we found that US and German participants had the most similar patterns of associations, followed by German and Malay participants. The largest group differences were between Malay and Netherlands-resident Chinese participants and between Dutch and Malaysian-Chinese participants. We conclude that culture plays a role in color-odor crossmodal associations, which likely arise, at least in part, through experience.

  14. Human salmonellosis associated with exotic pets.

    Science.gov (United States)

    Woodward, D L; Khakhria, R; Johnson, W M

    1997-11-01

    During the period from 1994 to 1996, an increase in the number of laboratory-confirmed cases of human salmonellosis associated with exposure to exotic pets including iguanas, pet turtles, sugar gliders, and hedgehogs was observed in Canada. Pet turtle-associated salmonellosis was recognized as a serious public health problem in the 1960s and 1970s, and in February 1975 legislation banning the importation of turtles into Canada was enacted by Agriculture Canada. Reptile-associated salmonellosis is once again being recognized as a resurgent disease. From 1993 to 1995, there were more than 20,000 laboratory-confirmed human cases of salmonellosis in Canada. The major source of Salmonella infection is food; however, an estimated 3 to 5% of all cases of salmonellosis in humans are associated with exposure to exotic pets. Among the isolates from these patients with salmonellosis, a variety of Salmonella serotypes were also associated with exotic pets and included the following: S. java, S. stanley, S. poona, S. jangwani, S. tilene, S. litchfield, S. manhattan, S. pomona, S. miami, S. rubislaw, S. marina subsp. IV, and S. wassenaar subsp. IV.

  15. Phase formation of physically associating polymer blends

    International Nuclear Information System (INIS)

    Tanaka, Fumihiko

    1993-01-01

    Polymers exhibit a variety of condensed phases when some of their segments are capable of forming weak bonds which can be created and destroyed by thermal motion. Transition from one phase to another caused by such 'segment association' is reversible by the change of the temperature and the concentration, so that it is called 'reversible phase transition'. What types of reversible phase formation are possible for a given associative interaction? What is the most fundamental laws which govern the competition between molecular association and phase separation? This paper surveys, as typical examples of reversible phases, macroscopic phase separation, microphase formation, solvation, gelation, etc. from the unified point of view, and explores the possibility of new condensed phases caused by their mutual interference. (author)

  16. Fracture risk associated with use of antibiotics

    DEFF Research Database (Denmark)

    Vestergaard, Peter

    2018-01-01

    BACKGROUND: Data have pointed at an impaired fracture healing with fluoroquinolones and thus potentially a decreased bone biomechanical competence. OBJECTIVES: To study fracture risk associated with antibiotics. METHODS: Case control study. There were 124,655 fracture cases and 373,962 age...... and gender matched controls. The main exposure was use of various groups of antibiotics. Confounder control was performed for social variables, contacts to hospitals and general practitioners, alcoholism and a number of other variables. RESULTS: An increased risk of any fracture (OR =1. 45, 95% CI: 1. 42 -1...... fractures with dicloxacillin and flucloxacillin. None of the other groups of antibiotics against bacteria, tuberculosis, virus, and fungi were systematically associated with any major change in the risk of fractures. CONCLUSION: Dicloxacillin and flucloxacillin seem associated with an increased risk...

  17. Extension of association models to complex chemicals

    DEFF Research Database (Denmark)

    Avlund, Ane Søgaard

    ; CPA and sPC-SAFT. Phase equilibrium and monomer fraction calculations with sPC-SAFT for methanol are used in the thesis to illustrate the importance of parameter estimation when using SAFT. Different parameter sets give similar pure component vapor pressure and liquid density results, whereas very......Summary of “Extension of association models to complex chemicals”. Ph.D. thesis by Ane Søgaard Avlund The subject of this thesis is application of SAFT type equations of state (EoS). Accurate and predictive thermodynamic models are important in many industries including the petroleum industry...... not account for steric self-hindrance for tree-like structures. An important practical problem is how to obtain optimal and consistent parameters. Moreover, multifunctional associating molecules represent a special challenge. In this work two equations of state using the SAFT theory for association are used...

  18. Association between serotonin transporter genotype and extraversion.

    Science.gov (United States)

    Gillihan, Seth J; Farah, Martha J; Sankoorikal, Geena Mary V; Breland, Jessica; Brodkin, Edward S

    2007-12-01

    Despite the long-standing recognition that extraversion is partially heritable, few specific genes have been found to be associated significantly with this personality trait. The purpose of this study was to examine the association between a functional genetic polymorphism of the serotonin transporter promoter region (5-HTTLPR) and extraversion. Caucasian participants (N=183) were genotyped for the 5-HTTLPR; extraversion scores for participants homozygous for the short allele (s/s) were compared with those participants carrying at least one long allele (s/l and l/l). An s/s genotype at 5-HTTLPR was significantly associated with self ratings of reduced extraversion (P=0.012); presence versus absence of the long allele explained 3.4% of the variance in extraversion. These findings provide support for the effect of the 5-HTTLPR, and for the serotonergic system more broadly, on behaviors related to extraversion.

  19. Associations between Mycobacterium tuberculosis Strains and Phenotypes

    Science.gov (United States)

    Brown, Timothy; Nikolayevskyy, Vladyslav; Velji, Preya

    2010-01-01

    To inform development of tuberculosis (TB) control strategies, we characterized a total of 2,261 Mycobacterium tuberculosis complex isolates by using multiple phenotypic and molecular markers, including polymorphisms in repetitive sequences (spoligotyping and variable-number tandem repeats [VNTRs]) and large sequence and single-nucleotide polymorphisms. The Beijing family was strongly associated with multidrug resistance (p = 0.0001), and VNTR allelic variants showed strong associations with spoligotyping families: >5 copies at exact tandem repeat (ETR) A, >2 at mycobacterial interspersed repetitive unit 24, and >3 at ETR-B associated with the East African–Indian and M. bovis strains. All M. tuberculosis isolates were differentiated into 4 major lineages, and a maximum parsimony tree was constructed suggesting a more complex phylogeny for M. africanum. These findings can be used as a model of pathogen global diversity. PMID:20113558

  20. Association between migraine, lifestyle and socioeconomic factors

    DEFF Research Database (Denmark)

    Le, Han; Tfelt-Hansen, Peer; Skytthe, Axel

    2011-01-01

    or studying. The risk was increased for men compared to women in subjects with heavy physical exercise, intake of alcohol, and body mass index >25. Migraine was associated with several lifestyle and socioeconomic factors. Most associations such as low education and employment status were probably due......To investigate whether sex-specific associations exist between migraine, lifestyle or socioeconomic factors. We distinguished between the subtypes migraine with aura (MA) and migraine without aura (MO). In 2002, a questionnaire containing validated questions to diagnose migraine and questions...... on lifestyle and socioeconomic factors was sent to 46,418 twin individuals residing in Denmark. 31,865 twin individuals aged 20-71 were included. The twins are representative of the Danish population with regard to migraine and other somatic diseases and were used as such in the present study. An increased...

  1. Severe gingival enlargement associated with aggressive periodontitis

    Directory of Open Access Journals (Sweden)

    Shyam Padmanabhan

    2013-01-01

    Full Text Available Enlargement of the gingiva can be due to various causes. Most prevalent are the inflammatory type and drug-induced type of gingival hyperplasia. However, sever enlargement associated with an aggressive type of periodontitis is an infrequent finding. Reported here is a case of a female patient aged 18 years who presented with severe enlargement of the maxillary and mandibular gingiva. Examination revealed enlargement extending up to the incisal edge of all the teeth and also an associated generalized loss of attachment with radiographic evidence of reduced bone height resembling an aggressive type of periodontitis. There were no associated systemic signs and symptoms or any family history except that there was generalized vitiligo of the skin and oral mucous membrane. The case was treated by gross electrosection of the gingiva.

  2. Track recognition with an associative pattern memory

    International Nuclear Information System (INIS)

    Bok, H.W. den; Visschers, J.L.; Borgers, A.J.; Lourens, W.

    1991-01-01

    Using Programmable Gate Arrays (PGAs), a prototype for a fast Associative Pattern Memory module has been realized. The associative memory performs the recognition of tracks within the hadron detector data acquisition system at NIKHEF-K. The memory matches the detector state with a set of 24 predefined tracks to identify the particle tracks that occur during an event. This information enables the trigger hardware to classify and select or discriminate the event. Mounted on a standard size (6U) VME board, several PGAs together form an associative memory. The internal logic architecture of the Gate Array is used in such a way as to minimize signal propagation delay. The memory cells, containing a binary representation of the particle tracks, are dynamically loadable through a VME bus interface, providing a high level of flexibility. The hadron detector and its readout system are briefly described and our track representation method is presented. Results from measurements under experimental conditions are discussed. (orig.)

  3. The association of exosomes with lymph nodes.

    Science.gov (United States)

    Hood, Joshua L

    2017-07-01

    Cells produce extracellular nanovesicles known as exosomes that transport information between tissue microenvironments. Exosomes can engage and regulate the function of various immune cell types facilitating both normal and pathological processes. It follows that exosomes should also associate with lymph nodes containing immune cells. Herein, data derived from investigations that incorporate experiments pertaining to the trafficking of exosomes to lymph nodes is reviewed. Within lymph nodes, direct evidence demonstrates that exosomes associate with dendritic cells, subcapsular sinus macrophages, B lymphocytes and stromal cells. Interactions with endothelial cells are also likely. The functional significance of these associations depends on exosome type. Continued investigations into the relationship between exosomes and lymph nodes will further our understanding of how exosomes regulate immune cells subsets and may serve to inspire new exosome based therapeutics to treat a variety of diseases. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Psychotic Symptoms Associated with Left Caudate Infarction

    Directory of Open Access Journals (Sweden)

    Ying-Chih Cheng

    2015-09-01

    Full Text Available Psychotic symptoms following acquired brain lesion are relatively rare, and thus, the specific association linking such symptoms to the distinct brain structure remains unclear. The frontal–subcortical circuits are thought to modulate motor activity and human behavior, and have been reported to be associated with many neuropsychiatric symptoms. We herein report the case of a 77-year-old man without previous psychiatric disorder who developed a new onset of psychotic symptoms following left caudate infarction. The presented case supports the fact that psychosis might arise from alteration of the distinct brain structure. The functional impairment of the frontal–subcortical circuits may be a critical factor linking the pathogenesis of psychosis associated with acquired brain lesion.

  5. Neuroimaging of HIV-associated neurocognitive disorders

    Directory of Open Access Journals (Sweden)

    Michel Elyas Jung Haziot

    Full Text Available ABSTRACT A significant increase in the incidence of cognitive impairment in HIV/AIDS patients has been continuously observed. Consequently, three classification categories of cognitive impairment have been proposed: asymptomatic neurocognitive impairment (ANI and mild neurocognitive disorder (MND, that correspond to the mild and intermediate forms, and HIV-associated dementia (HAD for the most severe cases. HIV-associated neurocognitive disorders (HAND is a broad term that encompasses these three categories. Moreover, the application of neuroimaging methods has led to a major breakthrough in understanding of the neurological changes in HIV, providing greater reliability in the exclusion of associated diseases and allowing earlier diagnosis. Therefore, abnormalities and/or specific neuroimaging elements may soon be incorporated into the HAND classification criteria, which will be of great value in the management of these diseases, including in the optimization of high CNS penetration antiretroviral regimens.

  6. Genetics in psychiatry: common variant association studies

    Directory of Open Access Journals (Sweden)

    Buxbaum Joseph D

    2010-03-01

    Full Text Available Abstract Many psychiatric conditions and traits are associated with significant heritability. Genetic risk for psychiatric conditions encompass rare variants, identified due to major effect, as well as common variants, the latter analyzed by association analyses. We review guidelines for common variant association analyses, undertaking after assessing evidence of heritability. We highlight the importance of: suitably large sample sizes; an experimental design that controls for ancestry; careful data cleaning; correction for multiple testing; small P values for positive findings; assessment of effect size for positive findings; and, inclusion of an independent replication sample. We also note the importance of a critical discussion of any prior findings, biological follow-up where possible, and a means of accessing the raw data.

  7. Association between migraine, lifestyle and socioeconomic factors

    DEFF Research Database (Denmark)

    Le, Han; Tfelt-Hansen, Peer; Skytthe, Axel

    2011-01-01

    To investigate whether sex-specific associations exist between migraine, lifestyle or socioeconomic factors. We distinguished between the subtypes migraine with aura (MA) and migraine without aura (MO). In 2002, a questionnaire containing validated questions to diagnose migraine and questions...... on lifestyle and socioeconomic factors was sent to 46,418 twin individuals residing in Denmark. 31,865 twin individuals aged 20-71 were included. The twins are representative of the Danish population with regard to migraine and other somatic diseases and were used as such in the present study. An increased...... or studying. The risk was increased for men compared to women in subjects with heavy physical exercise, intake of alcohol, and body mass index >25. Migraine was associated with several lifestyle and socioeconomic factors. Most associations such as low education and employment status were probably due...

  8. Neurobiology of inflammation-associated anorexia

    Directory of Open Access Journals (Sweden)

    Laurent Gautron

    2010-01-01

    Full Text Available Compelling data demonstrate that inflammation-associated anorexia directly results from the action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous system. For instance, the aforementioned pro-inflammatory factors can stimulate the activity of peripheral sensory neurons, and induce their own de novo synthesis and release into the brain parenchyma and cerebrospinal fluid. Ultimately, it results in the mobilization of a specific neural circuit that shuts down appetite. The present article describes the different cell groups and neurotransmitters involved in inflammation-associated anorexia and examines how they interact with neural systems regulating feeding such as the melanocortin system. A better understanding of the neurobiological mechanisms underlying inflammation-associated anorexia will help to develop appetite stimulants for cancer and AIDS patients.

  9. Factors associated with myelopathy in spinal tuberculosis

    International Nuclear Information System (INIS)

    Kitada, Yuki; Izawa, Kazutaka; Imoto, Kazuhiko; Yonenobu, Kazuo

    2009-01-01

    To identity factors associated with Pott's disease, 49 spinal tuberculosis patients were classified into a group of 22 patients with a neurological deficit and a group of 27 patients with no neurological deficits, and their clinical findings (gender, age, pulmonary tuberculosis, antituberculous chemotherapy, C reactive protein (CRP), nutritional status, and duration of disease) and radiographic findings (degree of canal encroachment, pathology and level of dural compression, number of affected vertebral bodies, range of paravertebral abscesses, signals in the spinal cord on MRI, kyphotic angle, and spinal instability) were compared. The results showed that malnutrition, severe canal encroachment, and abnormal signal within the spinal cord on MRI were associated with neurological complications. Factors associated with the degree of neurological deficit were unclear because the study population was too small. (author)

  10. Association of igneous phophate and uranium

    International Nuclear Information System (INIS)

    Loureiro, F.E.V.L.

    1980-10-01

    Data from Catalao permit some brief comments about the association of igneous phosphate and uranium, and on the possible economic importance of this type of mineralization in spite of the low grades of metals observed. Chemical and mineralogical analyses of carbonatites, phosphate ore and different phosphate concentrates, reveal the existence of important low-grade reserves of Th, Nb, Zr, U and La, and possibly of other metals such as V and Cu. Uranium is enriched 1.6 and 1.2 times, respectively, in the residual muds and flotation wastes produced at the processing plant of Goiasfertil operating in the area. The uranium is associated with two types of minerals, the first one comprised primarily of phosphates of the gorceixite group and secondarily of apatite and dahllite. THe second association is with pyrochlore, or rather barium-pyrochlore. Further investigations of similar occurences may define more clearly and specifically the various factors controlling the observed enrichment in heavy elements. (Author) [pt

  11. Vasculitis associated with connective tissue diseases.

    Science.gov (United States)

    Cozzani, E; Gasparini, G; Papini, M; Burlando, M; Drago, F; Parodi, A

    2015-04-01

    Vasculitis in connective tissue disease (CTD) is quite rare, it is reported in approximately 10% of patients with CTD; systemic lupus erythematosus (SLE) shows the highest association rate. Vessels of any size may be involved, but mainly small vessels vasculitis is reported. At present the classification of these vasculitis is unsatisfactory. According to the 2012 revised International Chapel Hill Consensus Conference, vasculitides secondary to CTD are a well identified entity and are classified under the category of "vasculitis associated with systemic disease". However only lupus vasculitis and rheumatoid vasculitis are explicitly listed, while the remaining are generically included under the heading "others". Petechiae, purpura, gangrene and ulcers are the most frequent cutaneous manifestations that should investigated in order to rule out potentially dangerous systemic involvement, especially if cryoglobulinemic or necrotizing vasculitis are suspected. This review will focus on the cutaneous involvement in CTD associated vasculitis.

  12. Association of atopic dermatitis with smoking

    DEFF Research Database (Denmark)

    Kantor, Robert; Kim, Ashley; Thyssen, Jacob P

    2016-01-01

    BACKGROUND: Tobacco exposure might be a modifiable risk factor for atopic dermatitis (AD). OBJECTIVE: We examine the association between AD and exposure to tobacco smoke. METHODS: We performed a systematic review and meta-analysis of observational studies (n = 86) in MEDLINE, EMBASE, Scopus......-sectional, longitudinal), study sizes (smoking (mild, extensive). RESULTS: A diagnosis of AD was associated with higher odds of active smoking (OR 1.87, 95% confidence interval 1.32-2.63) and exposure to passive smoke (OR 1.18, 95% confidence interval 1.......01-1.38), but not maternal smoking during pregnancy (OR 1.06, 95% confidence interval 0.80-1.40). The association between active smoking and AD remained significant in children and adults, all continents studied, and study sizes, but all were cross-sectional designs and had NOS score 6 or greater. Passive smoke...

  13. On Central Extensions of Associative Dialgebras

    Science.gov (United States)

    Rakhimov, Isamiddin S.

    2016-03-01

    The concept of central extensions plays an important in constructing extensions of algebras. This technique has been successfully used in the classification problem of certain classes of algebras. In 1978 Skjelbred and Sund reduced the classification of nilpotent Lie algebras in a given dimension to the study of orbits under the action of automorphism group on the space of second degree cohomology of a smaller Lie algebra with coefficients in a trivial module. Then W. de Graaf applied the Skjelbred and Sund method to the classification problem of low-dimensional nilpotent Lie and associative algebras over some fields. The main purpose of this note is to establish elementary properties of central extensions of associative dialgebras and apply the above mentioned method to the classification of low dimensional nilpotent associative dialgebras.

  14. Epstein-Barr virus-associated lymphomas.

    Science.gov (United States)

    Shannon-Lowe, Claire; Rickinson, Alan B; Bell, Andrew I

    2017-10-19

    Epstein-Barr virus (EBV), originally discovered through its association with Burkitt lymphoma, is now aetiologically linked to a remarkably wide range of lymphoproliferative lesions and malignant lymphomas of B-, T- and NK-cell origin. Some occur as rare accidents of virus persistence in the B lymphoid system, while others arise as a result of viral entry into unnatural target cells. The early finding that EBV is a potent B-cell growth transforming agent hinted at a simple oncogenic mechanism by which this virus could promote lymphomagenesis. In reality, the pathogenesis of EBV-associated lymphomas involves a complex interplay between different patterns of viral gene expression and cellular genetic changes. Here we review recent developments in our understanding of EBV-associated lymphomagenesis in both the immunocompetent and immunocompromised host.This article is part of the themed issue 'Human oncogenic viruses'. © 2017 The Authors.

  15. DISCRIMINATION BY ASSOCIATION IN EUROPEAN LAW

    Directory of Open Access Journals (Sweden)

    Cătălina-Adriana Ivănuș

    2013-11-01

    Full Text Available The european law prohibit direct and indirect discrimination and harrasment on grounds of sex, racial or ethnic, religion or belief, disability, age or sexual orientation. The question is what is the situation when someone is discriminated on can claim to be the victim of unlawful discrimination because he or she is associated with another person who has the protected characteristic. The the Court of Justice of the European Union’s judgment in Coleman v Attridge Law and Steve Law confirms, for the first time in European law, the existence of the concept of discrimination by association. In this article I examine the implications of this case on all conceps of discrimination concepts of discrimination in European law (direct discrimination, indirect discrimination and harassment. I also examine the application of discrimination by association to grounds other than disability.

  16. Data fusion using dynamic associative memory

    Science.gov (United States)

    Lo, Titus K. Y.; Leung, Henry; Chan, Keith C. C.

    1997-07-01

    An associative memory, unlike an addressed memory used in conventional computers, is content addressable. That is, storing and retrieving information are not based on the location of the memory cell but on the content of the information. There are a number of approaches to implement an associative memory, one of which is to use a neural dynamical system where objects being memorized or recognized correspond to its basic attractors. The work presented in this paper is the investigation of applying a particular type of neural dynamical associative memory, namely the projection network, to pattern recognition and data fusion. Three types of attractors, which are fixed-point, limit- cycle, and chaotic, have been studied, evaluated and compared.

  17. Gyrokinetic magnetohydrodynamics and the associated equilibria

    Science.gov (United States)

    Lee, W. W.; Hudson, S. R.; Ma, C. H.

    2017-12-01

    The gyrokinetic magnetohydrodynamic (MHD) equations, related to the recent paper by W. W. Lee ["Magnetohydrodynamics for collisionless plasmas from the gyrokinetic perspective," Phys. Plasmas 23, 070705 (2016)], and their associated equilibria properties are discussed. This set of equations consists of the time-dependent gyrokinetic vorticity equation, the gyrokinetic parallel Ohm's law, and the gyrokinetic Ampere's law as well as the equations of state, which are expressed in terms of the electrostatic potential, ϕ, and the vector potential, A , and support both spatially varying perpendicular and parallel pressure gradients and the associated currents. The corresponding gyrokinetic MHD equilibria can be reached when ϕ→0 and A becomes constant in time, which, in turn, gives ∇.(J∥+J⊥)=0 and the associated magnetic islands, if they exist. Examples of simple cylindrical geometry are given. These gyrokinetic MHD equations look quite different from the conventional MHD equations, and their comparisons will be an interesting topic in the future.

  18. Association between Contact allergy and Psoriasis

    DEFF Research Database (Denmark)

    Bangsgaard, Nannie

    2011-01-01

    6. SUMMERY 6.1 Summery in English Allergic contact dermatitis (ACD) and psoriasis are the two most prevalent skin diseases in the western world. ACD is the clinical manifestation of contact allergy. Contact allergy and psoriasis are both due to inflammatory mechanisms involving the innate...... and adaptive immune system. Psoriasis is conceived to be an autoimmune disease. Recent studies have suggested an inverse relation between contact allergy and autoimmune diseases. The association between contact allergy and psoriasis could reveal mechanistic insights into both inflammatory processes....... The overall aim of this PhD study was to investigate the association between contact allergy and autoimmune disease, with focus on psoriasis. The work was done in three study parts. Part I Epidemiological studies. Part II Sensitization study and Part III Experimental studies. In part I the association between...

  19. The association between depression and mortality

    DEFF Research Database (Denmark)

    Christensen, Gunhild Tidemann; Maartensson, Solvej; Osler, Merete

    2017-01-01

    on depression, use of antidepressants and the Major Depression Inventory (MDI) from a survey in 2004, in which 58.8% (n=6292) of the men participated. Information on mortality and cause of death was retrieved from registers for the period between 2004 and 2011. RESULTS: Depression diagnosis from hospital...... registers as well as self-reported depression, use of antidepressants and having a high MDI-score were significantly associated with mortality from all, natural and unnatural causes. The associations were of a similar magnitude for the register-based measure of depression and for the survey-based measures......BACKGROUND: A number of studies have associated depression with a high mortality risk. However, in surveys, depression is often measured by self-reports in selected sub-samples, while register studies have been based on hospital diagnosis or purchase of antidepressants. We examined how different...

  20. Seronegative myasthenia gravis associated with malignant thymoma.

    Science.gov (United States)

    Richards, Jason; Howard, James F

    2017-05-01

    Myasthenia gravis (MG) is generally caused by antibodies directed against the neuromuscular junction, including antibodies against the postsynaptic nicotinic acetylcholine receptor (AChR). Pathologic abnormalities of the thymus gland, including thymoma, are associated with MG. We report a 56-year-old woman who presented with double vision. Single fiber EMG confirmed myasthenia gravis. AChR, striational muscle and MuSK antibodies were absent in the serum. Chest CT demonstrated a malignant thymoma. We report the first case of seronegative myasthenia gravis associated with malignant thymoma. The case challenges the conventional wisdom that all patients with thymoma associated MG test positive for antibodies against AChR. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. New association formed for hospital case managers.

    Science.gov (United States)

    1999-09-01

    A national board of case management professionals has established the Little Rock, AR-based American Case Management Association (ACMA), the first case management association specifically designed to address the needs and concerns of hospital and health system-based case managers. The formation of ACMA was motivated in part by the desire to foster closer cooperation between nurses and social workers in the acute care setting. The association's board and officers have equal representation from the nursing and social work professions. Members of ACMA will be able to take advantage of the following services: a job opportunities network, an information resource center, a director's forum, and a mentoring service. Annual membership dues are $135.

  2. [On the Chosen Pharmaceutical Association and "The Journal of the Chosen Pharmaceutical Association"].

    Science.gov (United States)

    Ushikubo, Hiroko; Chiba, Yoshihiko; Misawa, Miwa

    2008-01-01

    In the 20th century, the medical and pharmaceutical fields in Korea and Japan were markedly developed. There was a deep relationship between the two countries as Japan had annexed Korea from 1910 to 1945, until the end of World War II. The present study was performed to investigate the Chosen Pharmaceutical Association and "The Journal of the Chosen Pharmaceutical Association" to research part of the history of Korean pharmacology in those days. In 1914, the Chosen Pharmaceutical Association was established; Takasato Kojima was appointed as the first chairman. The first issue of "The Journal of the Chosen Pharmaceutical Association" was published in 1921 as the only chemical bulletin in Korea. The contents of the journals mainly consisted of academic papers, investigations on hygiene and health in Korea and management reports of the association. Concerning the academic papers, most of them were on studies of environmental health and medicinal plants in Korea. The Chosen Pharmaceutical Association was disbanded by 1945.

  3. Associations between Gun Violence Exposure, Gang Associations, and Youth Aggression: Implications for Prevention and Intervention Programs

    Directory of Open Access Journals (Sweden)

    Myriam Forster

    2015-01-01

    Full Text Available Using cross-sectional data collected from three middle schools in Southeast Los Angeles, we assessed the association of neighborhood violence exposure, gang associations, and social self-control with past week aggression in a sample of minority youth (n=164. Results from Poisson and logistic regression models showed that direct exposure to gun violence, having friends in gangs, and low social self control were all positively associated with past week aggression. Among girls, having gang affiliated family members was positively associated with aggression, whereas among boys having friends in gangs was associated with past week aggression. Subjective expectations of engagement in future interpersonal violence were associated with being male, having friends in gangs, and fear of neighborhood gun violence. We recommend that youth violence prevention and intervention programs address the impact of family, peers, and gun violence on student coping and identify students with low social self-control who could benefit from social and emotional skills training.

  4. VizieR Online Data Catalog: Star Clusters/Associations. I. Associations (Ruprecht+ 1982)

    Science.gov (United States)

    Ruprecht, J.; Balazs, B.; White, R. E.

    1998-02-01

    The catalog contains data and bibliographical citations for all 70 associations of the second edition of the "Catalogue of Star Clusters and Associations (CSCA)" edited by Alter et al. (1970) which includes data for open clusters, associations, globular clusters and extragalactic objects up to 1967 and "Supplement to the CSCA" by Ruprecht et al. (1982), which contains the supplementary data up to the end of 1973. Thus, the literature is covered through 1973. The catalog includes the years of the literature, references, authors, abbreviated journal references, diameters, distances and color indices of the associations, number of stars and spectral types of the stars in the associations, and identification of the Palomar Observatory Sky Survey Chart on which the association appears. (3 data files).

  5. Automated detection and association of surface waves

    Directory of Open Access Journals (Sweden)

    C. R. D. Woodgold

    1994-06-01

    Full Text Available An algorithm for the automatic detection and association of surface waves has been developed and tested over an 18 month interval on broad band data from the Yellowknife array (YKA. The detection algorithm uses a conventional STA/LTA scheme on data that have been narrow band filtered at 20 s periods and a test is then applied to identify dispersion. An average of 9 surface waves are detected daily using this technique. Beamforming is applied to determine the arrival azimuth; at a nonarray station this could be provided by poIarization analysis. The detected surface waves are associated daily with the events located by the short period array at Yellowknife, and later with the events listed in the USGS NEIC Monthly Summaries. Association requires matching both arrival time and azimuth of the Rayleigh waves. Regional calibration of group velocity and azimuth is required. . Large variations in both group velocity and azimuth corrections were found, as an example, signals from events in Fiji Tonga arrive with apparent group velocities of 2.9 3.5 krn/s and azimuths from 5 to + 40 degrees clockwise from true (great circle azimuth, whereas signals from Kuriles Kamchatka have velocities of 2.4 2.9 km/s and azimuths off by 35 to 0 degrees. After applying the regional corrections, surface waves are considered associated if the arrival time matches to within 0.25 km/s in apparent group velocity and the azimuth is within 30 degrees of the median expected. Over the 18 month period studied, 32% of the automatically detected surface waves were associated with events located by the Yellowknife short period array, and 34% (1591 with NEIC events; there is about 70% overlap between the two sets of events. Had the automatic detections been reported to the USGS, YKA would have ranked second (after LZH in terms of numbers of associated surface waves for the study period of April 1991 to September 1992.

  6. Prioritizing genes associated with prostate cancer development

    International Nuclear Information System (INIS)

    Gorlov, Ivan P; Logothetis, Christopher J; Sircar, Kanishka; Zhao, Hongya; Maity, Sankar N; Navone, Nora M; Gorlova, Olga Y; Troncoso, Patricia; Pettaway, Curtis A; Byun, Jin Young

    2010-01-01

    The genetic control of prostate cancer development is poorly understood. Large numbers of gene-expression datasets on different aspects of prostate tumorigenesis are available. We used these data to identify and prioritize candidate genes associated with the development of prostate cancer and bone metastases. Our working hypothesis was that combining meta-analyses on different but overlapping steps of prostate tumorigenesis will improve identification of genes associated with prostate cancer development. A Z score-based meta-analysis of gene-expression data was used to identify candidate genes associated with prostate cancer development. To put together different datasets, we conducted a meta-analysis on 3 levels that follow the natural history of prostate cancer development. For experimental verification of candidates, we used in silico validation as well as in-house gene-expression data. Genes with experimental evidence of an association with prostate cancer development were overrepresented among our top candidates. The meta-analysis also identified a considerable number of novel candidate genes with no published evidence of a role in prostate cancer development. Functional annotation identified cytoskeleton, cell adhesion, extracellular matrix, and cell motility as the top functions associated with prostate cancer development. We identified 10 genes--CDC2, CCNA2, IGF1, EGR1, SRF, CTGF, CCL2, CAV1, SMAD4, and AURKA--that form hubs of the interaction network and therefore are likely to be primary drivers of prostate cancer development. By using this large 3-level meta-analysis of the gene-expression data to identify candidate genes associated with prostate cancer development, we have generated a list of candidate genes that may be a useful resource for researchers studying the molecular mechanisms underlying prostate cancer development

  7. Sequence robust association test for familial data.

    Science.gov (United States)

    Dai, Wei; Yang, Ming; Wang, Chaolong; Cai, Tianxi

    2017-09-01

    Genome-wide association studies (GWAS) and next generation sequencing studies (NGSS) are often performed in family studies to improve power in identifying genetic variants that are associated with clinical phenotypes. Efficient analysis of genome-wide studies with familial data is challenging due to the difficulty in modeling shared but unmeasured genetic and/or environmental factors that cause dependencies among family members. Existing genetic association testing procedures for family studies largely rely on generalized estimating equations (GEE) or linear mixed-effects (LME) models. These procedures may fail to properly control for type I errors when the imposed model assumptions fail. In this article, we propose the Sequence Robust Association Test (SRAT), a fully rank-based, flexible approach that tests for association between a set of genetic variants and an outcome, while accounting for within-family correlation and adjusting for covariates. Comparing to existing methods, SRAT has the advantages of allowing for unknown correlation structures and weaker assumptions about the outcome distribution. We provide theoretical justifications for SRAT and show that SRAT includes the well-known Wilcoxon rank sum test as a special case. Extensive simulation studies suggest that SRAT provides better protection against type I error rate inflation, and could be much more powerful for settings with skewed outcome distribution than existing methods. For illustration, we also apply SRAT to the familial data from the Framingham Heart Study and Offspring Study to examine the association between an inflammatory marker and a few sets of genetic variants. © 2017, The International Biometric Society.

  8. The European Nuclear Education Network Association - ENEN

    International Nuclear Information System (INIS)

    De Regge, P.P.

    2005-01-01

    The temporary network, established through the European 5 th Framework Programme project ENEN, was given a more permanent character by the foundation of the European Nuclear Education Network Association, a non-profit-making association according to the French law of 1901, pursuing a pedagogic and scientific aim. Its main objective is the preservation and the further development of higher nuclear education and expertise. This objective is realized through the co-operation between the European universities, involved in education and research in the nuclear engineering field, the nuclear research centres and the nuclear industry. The membership of the ENEN Association now consists of 35 universities members and 6 research centres. The paper briefly describes the history and structure of the ENEN Association and elaborates on the objectives and activities of its five committees during its first two years of operation. Supported by the 5 th and 6 th Framework Programme of the European Community, the ENEN Association established the delivery of the European Master of Science in Nuclear Engineering certificate. In particular, education and training courses have been developed and offered to materialise the core curricula and optional fields of study in a European exchange structure. Pilot editions of those courses and try-outs of training programmes have been successfully organised with a satisfying interest, attendance and performance by the students and the support of nuclear industries and international organisations. The involvement of ENEN in the 6 th EC Framework project EUROTRANS will further enlarge its field of activities into a realm of nuclear disciplines. The ENEN Association further contributes to the management of nuclear knowledge within the European Union as well as on a world-wide level, through contacts with its sister Network ANENT in Asia, and by its participation to activities of the World Nuclear University. (author)

  9. Factors associated with students' orientations to nursing.

    Science.gov (United States)

    Vanhanen, L; Janhonen, S

    2000-05-01

    Factors associated with students' orientations to nursing This paper presents the results of a study focusing on the factors associated with orientations to nursing. Students' orientations to nursing have not as yet been a focus of nursing research. In some other professions, however, professional orientation has been associated with learning motivation and study performance, and has been seen as a predictor of work satisfaction. In this study, students' orientations to nursing were defined in terms of caring, nursing expertise and life orientation. The hypothesis of whether students' pre-educational experiences of nursing, gender, choice of nursing specialty, problems with nursing studies and intention to stay in nursing were associated with different orientations was tested. The extent to which students were orientated to caring, nursing expertise and their own life was also examined. The orientation to nursing measurement tool, which has been developed on the basis of a qualitative study, was used to collect the data. Nurse teachers collected the data from nursing students (n=184) who were studying in three different nursing programmes in Finland. Non-parametric assessments (Mann-Whitney U-test and Kruskal-Wallis test) of the differences between the students' orientations were carried out. A majority of the students were highly life-orientated, and two-thirds had average nursing expertise or caring orientation scores. The results supported the study hypothesis of an association between students' orientations and their gender, choice of nursing speciality, problems with nursing studies and intention to stay in nursing. However, the hypothesis of an association between students' pre-educational nursing experiences and orientation to nursing was not supported. The contradictions between students' orientation to nursing and the philosophy of nursing underlying the study programme may be a source of motivational problems and dissatisfaction with nursing education

  10. Factors Associated with Fever in Intracerebral Hemorrhage.

    Science.gov (United States)

    Gillow, Sabreena J; Ouyang, Bichun; Lee, Vivien H; John, Sayona

    2017-06-01

    Fever is common in patients with intracerebral hemorrhage (ICH). We sought to identify predictors of fever in patients hospitalized with ICH, and compare infectious fever with noninfectious fever. A retrospective review on consecutive spontaneous ICH patients from April 2009 to March 2010 was performed. Fever was defined as temperature 100.9°F or higher and attributed to infectious versus noninfectious etiology, based upon the National Healthcare Safety Network criteria. Univariate analysis and multivariable logistic regression model were used to determine factors associated with fever and with infection. Among the 351 ICH patients, 136 (39%) developed fever. Factors associated with fever included mean ICH volume, intraventricular hemorrhage (IVH), external ventricular drain (EVD) placement or surgical evacuation, positive microbial cultures, longer length of stay (LOS), and higher in-hospital mortality. Among patients with fever, 96 (71%) were noninfectious and 40 (29%) were infectious. Infectious fever was associated with higher LOS. Noninfectious fever was associated with higher in-hospital mortality. In multivariable analysis, ICH volume (OR = 1.01, P = .04), IVH (OR = 2.0, P = .03), EVD (OR = 3.7, P fever. Infectious fever (OR = 5.26, P = .004), EVD (OR = 4.86, P = .01), and surgical evacuation (OR = 4.77, P = .04) correlated with prolonged LOS when dichotomized using a median of 15 days. Fever is common in ICH patients and is not associated with a clear infectious etiology in the majority of patients. Patients with noninfectious fever have higher in-hospital mortality, but survivors have shorter LOS. Further studies are warranted to better understand fevers in ICH. Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  11. Neonatal Outcomes Associated With Placental Abruption.

    Science.gov (United States)

    Downes, Katheryne L; Shenassa, Edmond D; Grantz, Katherine L

    2017-12-15

    Placental abruption (early separation of the placenta) is associated with preterm birth and perinatal mortality, but associations with other neonatal morbidities remain understudied. We examined the association between abruption and newborn outcomes. We analyzed 223,341 singleton deliveries from the Consortium on Safe Labor study, a retrospective, multisite, observational study (2002-2008) of electronic medical records in the United States. Adjusted relative risks, incidence rate ratios, and 99% confidence intervals were estimated. Direct effects attributable to abruption were examined by conditioning on intermediates (preterm birth and small for gestational age) with sensitivity analyses. Incidence of abruption was 1.6% (n = 3,619). Abruption was associated with an elevated risk of newborn resuscitation (relative risk (RR) = 1.5, 99% confidence interval (CI): 1.5, 1.6), apnea (RR = 5.8, 99% CI: 5.1, 6.5), asphyxia (RR = 8.5, 99% CI: 5.7, 11.3), respiratory distress syndrome (RR = 6.5, 99% CI: 5.9, 7.1), neonatal intensive care unit admission (RR = 3.4, 99% CI: 3.2, 3.6), longer intensive care length of stay (incidence rate ratio = 2.0, 99% CI: 1.9, 2.2), stillbirth (RR = 6.3, 99% CI: 4.7, 7.9), and neonatal mortality (RR = 7.6, 99% CI: 5.2, 10.1). In sensitivity analyses, there was a direct effect of abruption associated with increased neonatal risks. These findings expand our knowledge of the association between abruption and perinatal and neonatal outcomes. © The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  12. The European Nuclear Education Network Association - ENEN

    Energy Technology Data Exchange (ETDEWEB)

    Gentile, D. [Institut des Sciences et Techniques Nucleaires, CEA - Centre de Saclay, Bat. 395, F-91191 Gif-sur-Yvette (France)

    2006-07-01

    The temporary network, established through the European 5. Framework Programme project ENEN, was given a more permanent character by the foundation of the European Nuclear Education Network Association, a non-profit-making association according to the French law of 1901, pursuing a pedagogic and scientific aim. Its main objective is the preservation and the further development of higher nuclear education and expertise. This objective is realized through the co-operation between the European universities, involved in education and research in the nuclear engineering field, the nuclear research centres and the nuclear industry. The membership of the ENEN Association now consists of 35 universities members and 6 research centres. The paper briefly describes the history and structure of the ENEN Association and elaborates on the objectives and activities of its five committees during its first two years of operation. Supported by the 5. and 6. Framework Programme of the European Community, the ENEN Association established the delivery of the European Master of Science in Nuclear Engineering certificate. In particular, education and training courses have been developed and offered to materialize the core curricula and optional fields of study in a European exchange structure. Pilot editions of those courses and try-outs of training programmes have been successfully organised with a satisfying interest, attendance and performance by the students and the support of nuclear industries and international organisations. The involvement of ENEN in the 6. EC Framework project EUROTRANS will further enlarge its field of activities into a realm of nuclear disciplines. The ENEN Association further contributes to the management of nuclear knowledge within the European Union as well as on a world-wide level, through contacts with its sister Network ANENT in Asia, and by its participation to activities of the World Nuclear University. (author)

  13. The European Nuclear Education Network Association - ENEN

    International Nuclear Information System (INIS)

    Gentile, D.

    2006-01-01

    The temporary network, established through the European 5. Framework Programme project ENEN, was given a more permanent character by the foundation of the European Nuclear Education Network Association, a non-profit-making association according to the French law of 1901, pursuing a pedagogic and scientific aim. Its main objective is the preservation and the further development of higher nuclear education and expertise. This objective is realized through the co-operation between the European universities, involved in education and research in the nuclear engineering field, the nuclear research centres and the nuclear industry. The membership of the ENEN Association now consists of 35 universities members and 6 research centres. The paper briefly describes the history and structure of the ENEN Association and elaborates on the objectives and activities of its five committees during its first two years of operation. Supported by the 5. and 6. Framework Programme of the European Community, the ENEN Association established the delivery of the European Master of Science in Nuclear Engineering certificate. In particular, education and training courses have been developed and offered to materialize the core curricula and optional fields of study in a European exchange structure. Pilot editions of those courses and try-outs of training programmes have been successfully organised with a satisfying interest, attendance and performance by the students and the support of nuclear industries and international organisations. The involvement of ENEN in the 6. EC Framework project EUROTRANS will further enlarge its field of activities into a realm of nuclear disciplines. The ENEN Association further contributes to the management of nuclear knowledge within the European Union as well as on a world-wide level, through contacts with its sister Network ANENT in Asia, and by its participation to activities of the World Nuclear University. (author)

  14. [German Urological Associations under National Socialism].

    Science.gov (United States)

    Krischel, M; Moll, F; Fangerau, H

    2011-09-01

    The Deutsche Gesellschaft für Urologie (German Urological Association), established in 1907, was a German-Austrian medical society in which Jewish physicians held important positions. When the Nazis seized power in 1933, the Austrian Hans Rubritius was president of the society. The non-German presidency and the exclusion of Jewish colleagues from the professional society and medical practice led to a halt of the society's activities. At the same time in the mid 1930s, German urologists founded the Gesellschaft Reichsdeutscher Urologen (Association of Reichs-German Urologists) whose members aligned themselves with Nazi health policies and in turn received professional and personal benefits.

  15. Tracheal quadrifurcation associated with congenital heart disease

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, Venkatraman; Gadabanahalli, Karthik; Ahmad, Ozaire [Narayana Multispeciality Hospital and Mazumdar Shaw Cancer Center, Department of Radiology, Bangalore (India)

    2015-08-15

    Tracheal anomalies are known in association with congenital cardiac defects. Some of the well-described anomalies include accessory (displaced) tracheal bronchus with variants, tracheal trifurcation and accessory cardiac bronchus. Here we describe a case of tracheal quadrifurcation associated with complex congenital heart disease. Illustration of complex airway anatomy was simplified by the use of multidetector CT using a variety of image display options. Awareness of this complex anomaly will expand our knowledge of tracheal anomalies and equip the anesthesia and surgical team for better airway management. (orig.)

  16. Cardiomyopathy Associated with Celiac Disease in Childhood

    Directory of Open Access Journals (Sweden)

    Aleksandra Boskovic

    2012-01-01

    Full Text Available Celiac disease is predominantly a disease of the small intestine characterized by chronic malabsorption in genetically susceptible individuals who ingest grains containing gluten, such as wheat, barley, and rye. Although previously believed to be uncommon, celiac disease may be present in up to 1% of the adult and children population. Celiac disease is associated frequently with iron-deficiency anemia, dermatitis herpetiformis, selective IgA deficiency, thyroid disorders, diabetes mellitus, and various connective tissue disorders but is rarely associated with cardiomyopathy.

  17. Homocysteine increases the risk associated with hyperlipidaemia.

    LENUS (Irish Health Repository)

    Daly, Caroline

    2009-04-01

    The European Concerted Action Project \\'Homocysteine and Vascular Disease\\' showed that an elevated homocysteine is associated with a substantially increased risk of cardiovascular disease, and particularly when combined with other factors such as smoking, hypertension and hypercholesterolaemia. The purpose of this study was to examine the potential interactions between homocysteine and individual lipid subfractions. In addition, it was hypothesized that HDL cholesterol may protect against hyperhomocysteinaemia because HDL cholesterol is associated with the enzyme paroxonase, which reduces oxidization of homocysteine to the harmful metabolite, homocysteine thiolactonase.

  18. Cortical Thickness Changes Associated with Photoparoxysmal Response

    DEFF Research Database (Denmark)

    Hanganu, Alexandru; Groppa, Stanislav A; Deuschl, Günther

    2014-01-01

    Photoparoxysmal response (PPR) is an EEG trait of spike and spike-wave discharges in response to photic stimulation that is closely linked to idiopathic generalized epilepsy (IGE). In our previous studies we showed that PPR is associated with functional alterations in the occipital and frontal...... cortices. The aim of the present study was to determine structural changes associated with PPR. For this purpose we analysed the cortical thickness as derived from T1 MRI images in PPR-positive-subjects (n = 12; 15.5 ± 8.6 years; 4 males), PPR-positive-IGE-patients (n = 12; 14.9 ± 2.7 years; 4 males...

  19. Netherton syndrome associated with idiopathic congenital hemihypertrophy.

    Science.gov (United States)

    Yerebakan, Ozlem; Uğuz, Ayşen; Keser, Ibrahim; Lüleci, Güven; Ciftçioğlu, Mehmet Akif; Başaran, Erdal; Alpsoy, Erkan

    2002-01-01

    Netherton syndrome is a rare genodermatosis comprised of anichthyosiform dermatitis, hair shaft defects, and atopic features. Other problems associated with Netherton syndrome are delayed growth and development, immune abnormalities, recurrent infections, and intermittent aminoaciduria. We describe an 18-month-old girl with Netherton syndrome who had idiopathic congenital hemihypertrophy on her right side with contralateral benign nephromegaly in addition to the characteristic clinical signs of the syndrome. To our knowledge, this is the first case of Netherton syndrome associated with idiopathic congenital hemihypertrophy to be reported.

  20. Connective Tissue Disorder-Associated Vasculitis.

    Science.gov (United States)

    Sharma, Aman; Dhooria, Aadhaar; Aggarwal, Ashish; Rathi, Manish; Chandran, Vinod

    2016-06-01

    Vasculitides secondary to connective tissue diseases are classified under the category of 'vasculitis associated with systemic disease' in the revised International Chapel Hill Consensus Conference (CHCC) nomenclature. These secondary vasculitides may affect any of the small, medium or large vessels and usually portend a poor prognosis. Any organ system can be involved and the presentation would vary depending upon that involvement. Treatment depends upon the type and severity of presentation. In this review, we describe secondary vasculitis associated with rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, relapsing polychondritis, systemic sclerosis, Sjogren's syndrome and idiopathic inflammatory myositis, focusing mainly on recent advances in the past 3 years.

  1. The genesis of the association contract

    International Nuclear Information System (INIS)

    Segovia Salas Rodolfo

    2001-01-01

    The circumstances that gestated the installation of the association contract, with Ecopetrol like trustee of the underground are mentioned. The association contract, constituted a landmark in the history of the relationships between the country and the companies of the field, and that, during some time, it found imitators. Without being, by no means, revolutionary picked up dispersed elements of other legislations and recruiting modalities and it overturned them in a simple contract of adhesion. It is so simple their writing that has not given place to judicial reclamation some after having been subscribed by hundreds derived of their interpretation

  2. Association of Metabolic Syndrome and Hidradenitis Suppurativa

    DEFF Research Database (Denmark)

    Miller, Iben Marie; Ellervik, Christina; Vinding, Gabrielle Randskov

    2014-01-01

    IMPORTANCE An association between the metabolic syndrome (MetS) and chronic inflammatory diseases, such as psoriasis or rheumatoid arthritis, has been suggested.Hidradenitis suppurativa (HS), a more localized chronic inflammation of the skin, has been speculated to have a similar association......,predominantly female, and more often smokers compared with the non-HS group.EXPOSURE Hidradenitis suppurativa.MAIN OUTCOMES AND MEASURES Metabolic syndrome and its components of diabetes mellitus, hypertension, dyslipidemia, and obesity.RESULTS When compared with the non-HS group, the odds ratios (ORs...

  3. Association pityriasis rubra pilaire et myasthenie

    Directory of Open Access Journals (Sweden)

    Fatima Zahra Agharbi

    2011-09-01

    Full Text Available Le pityriasis rubra pilaire est un trouble de keratinisation rare dont l�etiopathogenie reste inconnue mais dont l�association avec autres pathologies a ete deja rapportee. Nous rapportons l�observation d�une jeune patiente qui presente un pityriasis rubra pilaire associe a une myasthenie. Traitee par Neostigmine et thymectomie avec bonne evolution sur le plan neurologique. Vu son desir de grossesse un traitement systemique de son pityriasis rubra pilaire n�a pas pu etre instaure et l�evolution sous dermocorticoides n�etait pas tres favorable.

  4. 2015 Association for Women in Mathematics Symposium

    CERN Document Server

    Lauter, Kristin; Chambers, Erin; Flournoy, Nancy; Grigsby, Julia; Martin, Carla; Ryan, Kathleen; Trivisa, Konstantina

    2016-01-01

    Presenting the latest findings in topics from across the mathematical spectrum, this volume includes results in pure mathematics along with a range of new advances and novel applications to other fields such as probability, statistics, biology, and computer science. All contributions feature authors who attended the Association for Women in Mathematics Research Symposium in 2015: this conference, the third in a series of biennial conferences organized by the Association, attracted over 330 participants and showcased the research of women mathematicians from academia, industry, and government.

  5. Associations between faith, distress and mental adjustment

    DEFF Research Database (Denmark)

    Johannessen-Henry, Christine Tind

    2013-01-01

    spiritual well-being, the faith dimension of spiritual well-being and aspects of performed faith are associated with distress and mental adjustment among cancer patients. Methods. In a cross-sectional design, 1043 survivors of various cancers filled in a questionnaire on spiritual well-being (FACIT-Sp-12...... = −0.79, CI −0.92; −0.66) and increased adjustment to cancer (fighting spirit, anxious preoccupation, helplessness-hopelessness). Specific aspects of faith were associated with high confusion-bewilderment and tension-anxiety, but also lower score on vigor-activity, and with higher anxious...

  6. Campylobacter gastroenteritis associated with Sweet's syndrome.

    Science.gov (United States)

    Pai, Sumita; Rytina, Ed; Sterling, Jane; Karas, J A; Aliyu, S H

    2012-10-01

    Sweet's syndrome or acute febrile neutrophilic dermatosis has been associated with underlying infection, malignancy, inflammatory disease and certain medications. The infection agents associated with this include Streptococcus species, Yersinia species, Chlamydia species, Salmonella species and Helicobacter pylori. We report a case of Sweet's syndrome in a 73-year-old woman following a 2 week course of severe gastroenteritis caused by Campylobacter species. Histological examination of skin lesions showed marked inflammatory infiltrate throughout the dermis, composed of neutrophils and histiocytes. The patient was successfully treated with topical and systemic steroids. To date, this is the first case of Sweet's syndrome to be reported linked to Campylobacter species to our knowledge.

  7. Dystonia Associated with Idiopathic Slow Orthostatic Tremor

    Directory of Open Access Journals (Sweden)

    Christopher Kobylecki

    2016-02-01

    Full Text Available Background: We aimed to characterize the clinical and electrophysiological features of patients with slow orthostatic tremor.Case Report: The clinical and neurophysiological data of patients referred for lower limb tremor on standing were reviewed. Patients with symptomatic or primary orthostatic tremor were excluded. Eight patients were identified with idiopathic slow 4–8 Hz orthostatic tremor, which was associated with tremor and dystonia in cervical and upper limb musculature. Coherence analysis in two patients showed findings different to those seen in primary orthostatic tremor.Discussion: Slow orthostatic tremor may be associated with dystonia and dystonic tremor.

  8. On construction of partial association rules

    KAUST Repository

    Moshkov, Mikhail

    2009-01-01

    This paper is devoted to the study of approximate algorithms for minimization of partial association rule length. It is shown that under some natural assumptions on the class NP, a greedy algorithm is close to the best polynomial approximate algorithms for solving of this NP-hard problem. The paper contains various bounds on precision of the greedy algorithm, bounds on minimal length of rules based on an information obtained during greedy algorithm work, and results of the study of association rules for the most part of binary information systems. © 2009 Springer Berlin Heidelberg.

  9. European Nuclear Education Network (ENEN) Association Initiative

    International Nuclear Information System (INIS)

    Comsa, Olivia; Meglea, Claudia; Banutoiu, Marina; Paraschiva, M. V.; Meglea, S.

    2003-01-01

    The main objective of the ENEN Association is the preservation and further development of a higher nuclear education and expertise. This objective should be achieved through the co-operation between European universities involved in education and research in the nuclear engineering field, research centers and the nuclear industry. To reach this objective, the ENEN Association has to: Promote and develop the collaboration in nuclear engineering education of engineers and researchers required by the nuclear industry and the regulatory bodies; Ensure the quality of nuclear academic engineering education and training; Increase the attractiveness for engagement in the nuclear field for students and young academics. The basic objectives of the ENEN Association shall be to: Deliver an European Master of Science Degree in Nuclear Engineering and promote PhD studies; Promote exchange of students and teachers participating in the frame of this network; Increase the number of students by providing incentives; Establish a framework for mutual recognition; Foster and strengthen the relationship with research laboratories and networks, industry and regulatory bodies, by involving them in (or association them with) nuclear academic education and by offering continuous training. The aims of the ENEN Association shall be achieved by: Discussion on educational objectives, methods and course contents among the members and with external partners, particularly national European industries; Organization of internal audits on the quality of nuclear engineering curricula; Awarding the label of 'European Master degree of Science in Nuclear Engineering' to the curricula satisfying the criteria set up by the ENEN Association; Cooperation between the members, and with the research centers and the nuclear industry for enhancement of mobility of teachers and students, organization of training and advanced courses, use of large research and teaching facilities or infrastructures; Cooperation

  10. Has risk associated with smoking increased?

    DEFF Research Database (Denmark)

    Prescott, E; Osler, M; Andersen, P K

    1997-01-01

    BACKGROUND: Two recent much cited publications have raised the concern that risk associated with cigarette smoking has so far been underestimated. In this study we wish to determine whether excess all-cause mortality associated with smoking has increased during the last 20-30 years in a study......,525 females, initially examined between 1964 and 1992 with examinations repeated at intervals from 1-10 years, were followed until 1995 for all-cause mortality. Relative mortality risk in smokers versus never-smokers was calculated within periods of five calendar years and compared throughout the study period...

  11. Suicide and Lyme and associated diseases

    Directory of Open Access Journals (Sweden)

    Bransfield RC

    2017-06-01

    Full Text Available Robert C Bransfield Department of Psychiatry, Rutgers-RWJ Medical School, Piscataway, NJ, USA Purpose: The aim of this paper is to investigate the association between suicide and Lyme and associated diseases (LAD. No journal article has previously performed a comprehensive assessment of this subject.Introduction: Multiple case reports and other references demonstrate a causal association between suicidal risk and LAD. Suicide risk is greater in outdoor workers and veterans, both with greater LAD exposure. Multiple studies demonstrate many infections and the associated proinflammatory cytokines, inflammatory-mediated metabolic changes, and quinolinic acid and glutamate changes alter neural circuits which increase suicidality. A similar pathophysiology occurs in LAD.Method: A retrospective chart review and epidemiological calculations were performed.Results: LAD contributed to suicidality, and sometimes homicidality, in individuals who were not suicidal before infection. A higher level of risk to self and others is associated with multiple symptoms developing after acquiring LAD, in particular, explosive anger, intrusive images, sudden mood swings, paranoia, dissociative episodes, hallucinations, disinhibition, panic disorder, rapid cycling bipolar, depersonalization, social anxiety disorder, substance abuse, hypervigilance, generalized anxiety disorder, genital–urinary symptoms, chronic pain, anhedonia, depression, low frustration tolerance, and posttraumatic stress disorder. Negative attitudes about LAD from family, friends, doctors, and the health care system may also contribute to suicide risk. By indirect calculations, it is estimated there are possibly over 1,200 LAD suicides in the US per year.Conclusion: Suicidality seen in LAD contributes to causing a significant number of previously unexplained suicides and is associated with immune-mediated and metabolic changes resulting in psychiatric and other symptoms which are possibly

  12. Myanmar Library Association Newsletter No. 2

    International Nuclear Information System (INIS)

    1995-04-01

    The news and articles related to the Myanmar Library Association (MLA) are contained in this issue in English language namely. 1. National library statistics, activities of the Sarpay Beikman public library and the list of books translated from English to Myanmar in the year 1994. Compiled by Daw Nu-Nu. 2. The Myanmar Library Association by U Tin - Maung - Lwin. 3. Librarians conference to be huge (extract from China Daily November 18, 1994). 4. Magic of computers in libraries by U Maung - Maung. 5. The two union catalogues of Myanmar by Hla-Win (MSTRD)

  13. Graded associative conformal algebras of finite type

    OpenAIRE

    Kolesnikov, Pavel

    2011-01-01

    In this paper, we consider graded associative conformal algebras. The class of these objects includes pseudo-algebras over non-cocommutative Hopf algebras of regular functions on some linear algebraic groups. In particular, an associative conformal algebra which is graded by a finite group $\\Gamma $ is a pseudo-algebra over the coordinate Hopf algebra of a linear algebraic group $G$ such that the identity component $G^0$ is the affine line and $G/G^0\\simeq \\Gamma $. A classification of simple...

  14. [Neurological outcome associated with influenza viral infection].

    Science.gov (United States)

    Kamimura, N; Matsuzaka, T; Tsuji, Y

    1997-04-01

    Several neurological complications associated with Influenza virus infection are known as a febrile convulsion, polyneuritis, meningitis, encephalomyelitis and encephalopathy. Influenza encephalopathy is the most severe complication associated with Influenza. It may be classified into several subtypes according to the clinical symptoms and laboratory data. In this review, Reye's syndrome, acute necrotizing encephalopathy and hemorrhagic shock and encephalopathy syndrome (HSE) are described in detail. The 1995 influenza pandemia in Nagasaki prefecture was markedly neurovirulent and lethal. Twelve cases developed influenza encephalopathy, and the mortality rate between them was 50%. Almost all of them had never be inoculated of influenza vaccine before.

  15. HTLV-1-associated infective dermatitis and probable HTLV-1- associated myelopathy in an adolescent female*

    Science.gov (United States)

    Steglich, Raquel Bisacotti; Tonoli, Renata Elise; Souza, Paulo Ricardo Martins; Pinto, Giselle Martins; Riesgo, Rudimar dos Santos

    2015-01-01

    Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (ID) is a chronic, severe and recurrent eczema occurring during childhood in patients vertically infected with HTLV-1. HTLV-1-associated myelopathy/tropical spastic paraparesia (HAM/ TSP) is slow and progressive. We report the case of an adolescent female from a non-endemic area for HTLV-1 who presents ID and, most likely, associated HAM/TSP. PMID:26312674

  16. Novel Loci Associated with Usual Sleep Duration: The CHARGE Consortium Genome-Wide Association Study

    Science.gov (United States)

    Gottlieb, Daniel J.; Hek, Karin; Chen, Ting-hsu; Watson, Nathaniel F.; Eiriksdottir, Gudny; Byrne, Enda M.; Cornelis, Marilyn; Warby, Simon C.; Bandinelli, Stefania; Cherkas, Lynn; Evans, Daniel S.; Grabe, Hans J.; Lahti, Jari; Li, Man; Lehtimäki, Terho; Lumley, Thomas; Marciante, Kristin D.; Pérusse, Louis; Psaty, Bruce M.; Robbins, John; Tranah, Gregory J.; Vink, Jacqueline M.; Wilk, Jemma B.; Stafford, Jeanette M.; Bellis, Claire; Biffar, Reiner; Bouchard, Claude; Cade, Brian; Curhan, Gary C.; Eriksson, Johan G.; Ewert, Ralf; Ferrucci, Luigi; Fülöp, Tibor; Gehrman, Philip R.; Goodloe, Robert; Harris, Tamara B.; Heath, Andrew C.; Hernandez, Dena; Hofman, Albert; Hottenga, Jouke-Jan; Hunter, David J.; Jensen, Majken K.; Johnson, Andrew D.; Kähönen, Mika; Kao, Linda; Kraft, Peter; Larkin, Emma K.; Lauderdale, Diane S.; Luik, Annemarie I.; Medici, Marco; Montgomery, Grant W.; Palotie, Aarno; Patel, Sanjay R.; Pistis, Giorgio; Porcu, Eleonora; Quaye, Lydia; Raitakari, Olli; Redline, Susan; Rimm, Eric B.; Rotter, Jerome I.; Smith, Albert V.; Spector, Tim D.; Teumer, Alexander; Uitterlinden, André G.; Vohl, Marie-Claude; Widen, Elisabeth; Willemsen, Gonneke; Young, Terry; Zhang, Xiaoling; Liu, Yongmei; Blangero, John; Boomsma, Dorret I.; Gudnason, Vilmundur; Hu, Frank; Mangino, Massimo; Martin, Nicholas G.; O’Connor, George T.; Stone, Katie L.; Tanaka, Toshiko; Viikari, Jorma; Gharib, Sina A.; Punjabi, Naresh M.; Räikkönen, Katri; Völzke, Henry; Mignot, Emmanuel; Tiemeier, Henning

    2015-01-01

    Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study of usual sleep duration was conducted using 18 population-based cohorts totaling 47,180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35–80 kb upstream from the thyroid-specific transcription factor PAX8 (lowest p=1.1 ×10−9). This finding was replicated in an African-American sample of 4771 individuals (lowest p=9.3 × 10−4). The strongest combined association was at rs1823125 (p=1.5 × 10−10, minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 minutes longer per night. The alleles associated with longer sleep duration were associated in previous genome-wide association studies with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease. PMID:25469926

  17. Treatment of Kaposi sarcoma-associated herpesvirus (KSHV-associated cancers

    Directory of Open Access Journals (Sweden)

    Dirk P Dittmer

    2012-04-01

    Full Text Available Kaposi sarcoma (KS is the most frequent AIDS-defining cancer worldwide. Kaposi sarcoma associated herpesvirus (KSHV is the etiological agent of KS, and the virus is also associated with two lymphoproliferative diseases. Both KS and KSHV-associated lymphomas, are cancers of unique molecular composition. They represent a challenge for cancer treatment and an opportunity to identify new mechanisms of transformation. Here, we review the current clinical insights into KSHV-associated cancers and discuss scientific insights into the pathobiology of KS, primary effusion lymphoma and multicentric Castleman’s disease.

  18. Bladder exstrophy associated with complete urethral duplication ...

    African Journals Online (AJOL)

    J.E. Mensah

    ees.elsevier.com/afju · www.sciencedirect.com. Case report. Bladder exstrophy associated with complete urethral duplication: Bladder can be augmented with dorsal urethral mucosa. J.E. Mensaha,∗. , K.N. Ampadua, M.Y. Kyeia, B. Edusieb.

  19. Asparaginase-associated pancreatitis in a dog.

    Science.gov (United States)

    Schleis, Stephanie E; Rizzo, Scott A; Phillips, Jeffery C; LeBlanc, Amy K

    2011-09-01

    A dog with lymphosarcoma was evaluated for vomiting, lethargy, and abdominal pain 48 h after treatment with L-asparaginase. Based on drug administration, clinical signs, bloodwork, and elevated canine pancreatic lipase immunoreactivity, L-asparaginase-associated pancreatitis was diagnosed. This is an acknowledged toxicity; however, its pathophysiology and incidence rate in veterinary patients are unknown and sparsely documented.

  20. Intestinal schistosomiasis associated with intussusception: a case ...

    African Journals Online (AJOL)

    Abstract: We report a case of intestinal schistosomiasis associated with iliocaecal intussusception resulting from obstructions of the terminal part of the ileum by schistosome egg-induced fibrosis. A 7- year-old boy presented with the history of abdominal pain and difficulties in passing stool for two months. Ultrasound ...