WorldWideScience

Sample records for toyota camry hev

  1. Evaluation of the 2007 Toyota Camry Hybrid Synergy Drive System

    Energy Technology Data Exchange (ETDEWEB)

    Burress, T A; Coomer, C L; Campbell, S L; Seiber, L E; Marlino, L D; Staunton, R H; Cunningham, J P

    2008-04-15

    The U.S. Department of Energy (DOE) and American automotive manufacturers General Motors, Ford, and DaimlerChrysler began a five-year, cost-shared partnership in 1993. Currently, hybrid electric vehicle (HEV) research and development is conducted by DOE through its FreedomCAR and Vehicle Technologies (FCVT) program. The mission of the FCVT program is to develop more energy efficient and environmentally friendly highway transportation technologies. Program activities include research, development, demonstration, testing, technology validation, and technology transfer. These activities are aimed at developing technologies that can be domestically produced in a clean and cost-competitive manner. Under the FCVT program, support is provided through a three-phase approach [1] which is intended to: • Identify overall propulsion and vehicle-related needs by analyzing programmatic goals and reviewing industry’s recommendations and requirements, then develop the appropriate technical targets for systems, subsystems, and component research and development activities; • Develop and validate individual subsystems and components, including electric motors, emission control devices, battery systems, power electronics, accessories, and devices to reduce parasitic losses; and • Determine how well the components and subassemblies work together in a vehicle environment or as a complete propulsion system and whether the efficiency and performance targets at the vehicle level have been achieved. The research performed in this area will help remove technical and cost barriers to enable technology for use in such advanced vehicles as hybrid electric, plug-in hybrid electric, electric, and fuel-cell-powered vehicles.

  2. Logic Model Checking of Unintended Acceleration Claims in the 2005 Toyota Camry Electronic Throttle Control System

    Science.gov (United States)

    Gamble, Ed; Holzmann, Gerard

    2011-01-01

    Part of the US DOT investigation of Toyota SUA involved analysis of the throttle control software. JPL LaRS applied several techniques, including static analysis and logic model checking, to the software. A handful of logic models were built. Some weaknesses were identified; however, no cause for SUA was found. The full NASA report includes numerous other analyses

  3. Assembling Toyota in Portugal

    OpenAIRE

    Machado, Tiago; Moniz, António

    2003-01-01

    A lot has been written over the last decade with regard to Toyota and the productive model associated to it (toyota-ism). And more specifically concerning the "(…) best-seller that changed the... sociological world" (Castillo, 1998: 31). But the case of Salvador Caetano’s Ovar Industrial Division (OID), that assembles Toyota light commercial vehicles in Portugal, allows us to put forward a sub-hypothesis that fits into the analysis schema proposed in the First GERPISA International Program – ...

  4. HEV and cirrhosis: methods

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. HEV and cirrhosis: methods. Study group. Patients with cirrhosis and recent jaundice for <30 d. Controls. Patients with liver cirrhosis but no recent worsening. Exclusions. Significant alcohol consumption. Recent hepatotoxic drugs. Recent antiviral therapy. Recent ...

  5. Toyota hybrid synergy drive

    Energy Technology Data Exchange (ETDEWEB)

    Gautschi, H.

    2008-07-01

    This presentation made at the Swiss 2008 research conference on traffic by Hannes Gautschi, director of service and training at the Toyota company in Switzerland, takes a look at Toyota's hybrid drive vehicles. The construction of the vehicles and their combined combustion engines and electric generators and drives is presented and the combined operation of these components is described. Braking and energy recovery are discussed. Figures on the performance, fuel consumption and CO{sub 2} output of the hybrid vehicles are compared with those of conventional vehicles.

  6. A Study on Magnetic Decoupling of Compound-Structure Permanent-Magnet Motor for HEVs Application

    Directory of Open Access Journals (Sweden)

    Qiwei Xu

    2016-10-01

    Full Text Available The compound-structure permanent-magnet (CSPM motor is used for an electrical continuously-variable transmission (E-CVT in a hybrid electric vehicle (HEV. It can make the internal combustion engine (ICE independent of the road loads and run in the high efficiency area to improve the fuel economy and reduce the emissions. This paper studies the magnetic coupling of a new type of CSPM motor used in HEVs. Firstly, through the analysis of the parameter matching with CSPM in the HEV, we receive the same dynamic properties’ design parameters between the CSPM motor and the THS (Toyota Hybrid System of the Toyota Prius. Next, we establish the equivalent magnetic circuit model of the overall and the secondary model considering the tangential and radial flux distribution in the outer rotor of the CSPM motor. Based on these two models, we explore the internal magnetic coupling rule of the CSPM motor. Finally, finite element method analysis in 2D-ansoft is used to analyze the magnetic field distribution of the CSPM motor in different operation modes. By the result of the finite element method analysis, the internal magnetic decoupling scheme is put forward, laying the theoretical foundation for the further application of the CSPM motor in HEVs.

  7. The importance of vehicle costs, fuel prices, and fuel efficiency to HEV market success.

    Energy Technology Data Exchange (ETDEWEB)

    Santini, D. J.; Patterson, P. D.; Vyas, A. D.

    1999-12-08

    Toyota's introduction of a hybrid electric vehicle (HEV) named ''Prius'' in Japan and Honda's proposed introduction of an HEV in the United States have generated considerable interest in the long-term viability of such fuel-efficient vehicles. A performance and cost projection model developed entirely at Argonne National Laboratory (ANL) is used here to estimate costs. ANL staff developed fuel economy estimates by extending conventional vehicle (CV) modeling done primarily under the National Cooperative Highway Research Program. Together, these estimates are employed to analyze dollar costs vs. benefits of two of many possible HEV technologies. We project incremental costs and fuel savings for a Prius-type low-performance hybrid (14.3 seconds zero to 60 mph acceleration, 260 time) and a higher-performance ''mild'' hybrid vehicle, or MHV (11 seconds 260 time). Each HEV is compared to a U.S. Toyota Corolla with automatic transmission (11 seconds 260 time). The base incremental retail price range, projected a decade hence, is $3,200-$3,750, before considering battery replacement cost. Historical data are analyzed to evaluate the effect of fuel price on consumer preferences for vehicle fuel economy, performance, and size. The relationship between fuel price, the level of change in fuel price, and consumer attitude toward higher fuel efficiency is also evaluated. A recent survey on the value of higher fuel efficiency is presented and U.S. commercial viability of the hybrids is evaluated using discount rates of 2090 and 870. Our analysis, with our current HEV cost estimates and current fuel savings estimates, implies that the U.S. market for such HEVS would be quite limited.

  8. Markkinointitutkimus : Case: Toyota Airport

    OpenAIRE

    Sonne, Emilia

    2012-01-01

    Tämä opinnäytetyö pyrkii selvittämään, miten Toyota Airportin markkinointi on onnistunut ja miten sitä voisi tulevaisuudessa kehittää. Työn tarve syntyi kohdeyrityksen halusta selvittää asiakkaiden ja potentiaalisten asiakkaiden keskuudessa mielipiteitä yrityksen mainonnasta. Työn tarkoituksena oli kartoittaa markkinoinnin nykytilaa ja potentiaalisia viestintäkanavia. Teoreettinen viitekehys keskittyy markkinointiin ja mainontaan. Opinnäytetyössä käytettiin useita eri kirjallisia markkin...

  9. Learning to lead at Toyota.

    Science.gov (United States)

    Spear, Steven J

    2004-05-01

    Many companies have tried to copy Toyota's famous production system--but without success. Why? Part of the reason, says the author, is that imitators fail to recognize the underlying principles of the Toyota Production System (TPS), focusing instead on specific tools and practices. This article tells the other part of the story. Building on a previous HBR article, "Decoding the DNA of the Toyota Production System," Spear explains how Toyota inculcates managers with TPS principles. He describes the training of a star recruit--a talented young American destined for a high-level position at one of Toyota's U.S. plants. Rich in detail, the story offers four basic lessons for any company wishing to train its managers to apply Toyota's system: There's no substitute for direct observation. Toyota employees are encouraged to observe failures as they occur--for example, by sitting next to a machine on the assembly line and waiting and watching for any problems. Proposed changes should always be structured as experiments. Employees embed explicit and testable assumptions in the analysis of their work. That allows them to examine the gaps between predicted and actual results. Workers and managers should experiment as frequently as possible. The company teaches employees at all levels to achieve continuous improvement through quick, simple experiments rather than through lengthy, complex ones. Managers should coach, not fix. Toyota managers act as enablers, directing employees but not telling them where to find opportunities for improvements. Rather than undergo a brief period of cursory walk-throughs, orientations, and introductions as incoming fast-track executives at most companies might, the executive in this story learned TPS the long, hard way--by practicing it, which is how Toyota trains any new employee, regardless of rank or function.

  10. ACT OF IMPLEMENTATION OF TOYOTA SYSTEM

    OpenAIRE

    Damjan Stanojević; Slobodan Stefanović; Branislav Stanisavljević; Dragoslav Ilić

    2013-01-01

    The production system developed by Toyota Motor Corporation was developed to provide best quality, lowest costs, and shortest lead time through the elimination of losts. Kiichiro Toyota, son of Sakichi and founder of the Toyota automobile factory, developed the concept of Just-in-Time in the 1930's. He decreed that by this act Toyota would contain no excess inventory and that Toyota would strive to work both in partnership with suppliers and level production. The Toyot...

  11. HEV

    African Journals Online (AJOL)

    Moatez Billah HARIDA

    Hybrid Electrical Vehicle Model Balance Fidelity and Speed (HEVMBFS) .... introduced to the automatic control engineering community for the ..... Incorporating Engine Transient Characteristics, IEEE transactions on vehicular technology, no.

  12. Kuidas Toyota suureks kasvas / Mart Kuusk

    Index Scriptorium Estoniae

    Kuusk, Mart

    2004-01-01

    Maailma kasumlikumaks autotootjaks tõusnud Toyota edukusest maailmas, selle võimalikest põhjustest ning veel suurema turuosa hõivamisega seotud tulevikuplaanidest. Vt. samas: Toyota aktsia on sellel aastal hinnas

  13. Evaluation of the 2010 Toyota Prius Hybrid Synergy Drive System

    Energy Technology Data Exchange (ETDEWEB)

    Burress, Timothy A [ORNL; Campbell, Steven L [ORNL; Coomer, Chester [ORNL; Ayers, Curtis William [ORNL; Wereszczak, Andrew A [ORNL; Cunningham, Joseph Philip [ORNL; Marlino, Laura D [ORNL; Seiber, Larry Eugene [ORNL; Lin, Hua-Tay [ORNL

    2011-03-01

    Subsystems of the 2010 Toyota Prius hybrid electric vehicle (HEV) were studied and tested as part of an intensive benchmarking effort carried out to produce detailed information concerning the current state of nondomestic alternative vehicle technologies. Feedback provided by benchmarking efforts is particularly useful to partners of the Vehicle Technologies collaborative research program as it is essential in establishing reasonable yet challenging programmatic goals which facilitate development of competitive technologies. The competitive nature set forth by the Vehicle Technologies Program (VTP) not only promotes energy independence and economic stability, it also advocates the advancement of alternative vehicle technologies in an overall global perspective. These technologies greatly facilitate the potential to reduce dependency on depleting natural resources and mitigate harmful impacts of transportation upon the environment.

  14. Toyota ületas kiirust / Tarvo Vaarmets

    Index Scriptorium Estoniae

    Vaarmets, Tarvo

    2007-01-01

    Jaapani autotootja Toyota Motor ületas majandusaasta esimese poole tulemuste põhjal USA konkurenti General Motorsit automüügi, tootmismahtude ja käibe osas. Edasiste prognooside osas jääb Toyota Motor siiski konservatiivseks. Diagramm: Toyota Motori aktsia on aastaga tõusnud 16 protsenti

  15. Toyota Aktiivi -kampanja ja markkinointi

    OpenAIRE

    Peltola, Jouni

    2015-01-01

    Opinnäytetyön aiheena oli kehittää markkinointisuunnitelma Tampereella toimivalle Toyota Autotalot Oy -autoliikkeelle. Suunnittelun kohteena oli syksyllä 2014 valtakunnallisesti lanseerattu Toyota Aktiivi -huoltokampanja, jonka tarkoituksena on kasvattaa vanhempien autojen markkinaosuutta merkkihuollossa. Kampanjan ja tämän työn taustalla on Suomen ajoneuvokannan ikääntyminen, johon pyritään mukautumaan kehittämällä ja markkinoimalla uusia, kuluttajaystävällisempiä huolto-ohjelmia vanhempien ...

  16. Hepatitis E Virus (HEV) Infection in Ireland

    LENUS (Irish Health Repository)

    Hickey, C

    2016-09-01

    Hepatitis E virus (HEV) is a single stranded RNA virus causing infection worldwide. In developing countries HEV genotypes 1 and 2 spread faeco-orally via water. Recently, infections with HEV have been detected in Europe and North America in patients with no travel history. These are food-borne HEV genotypes 3 and 4, a pig-associated zoonosis. Most infections are asymptomatic but morbidity and chronic infection may occur with prior liver disease or immunosuppression. International seroprevalence rates vary and with improved diagnostics have increased. To determine the current prevalence in this region we studied anonymised serum samples submitted in 2015 for routine testing. We detected anti-HEV IgG in 16\\/198 (8%) individuals, highest rate in 40-59 year olds (43.8%). This is higher than reported for the same region in 1995 (0.4%) using a previous generation assay. This study provides evidence of HEV circulation in Ireland and reinforces the need for ongoing surveillance.

  17. Siklus Daur Hidup Mobil Toyota Avanza dan Strategi Pemasaran pada PT Toyota Astra Motor

    OpenAIRE

    Alvi, Zahra Waini

    2013-01-01

    The title of this research is "Life Cycle of Toyota Avanza and Strategic Marketing at PT Toyota Astra Motor". In determining marketing strategy, a company must know step of a product in product life cycle with a purpose to that company can take policy to product in every step, in this case is Toyota Avanza product at PT Toyota Astra Motor. At this research, applied marketing strategy based on product life cycle developed with marketing mix ( product, price, place, and promotion). This stud...

  18. Improving Formwork Engineering Using the Toyota Way

    OpenAIRE

    Jiun-De Kuo; Wei-Chieh Wang; Chien-Ho Ko

    2011-01-01

    Construction is a labor-intensive industry with formwork engineering requiring a disproportionate amount of labor and costs. Formwork accounts for approximately one-third of the cost of reinforced concrete construction, partly because traditional formwork processes frequently result in delivery delays and material waste. The purpose of this research is to adapt production concepts pioneered by Toyota (the “Toyota Way”) to improve formwork engineering. The Toyota Way of production consists of ...

  19. Lower-Energy Energy Storage System (LEESS) Evaluation in a Full-Hybrid Electric Vehicle (HEV) (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Cosgrove, J.; Gonder, J.; Pesaran, A.

    2013-11-01

    The cost of hybrid electric vehicles (HEVs) (e.g., Toyota Prius or Ford Fusion Hybrid) remains several thousand dollars higher than the cost of comparable conventional vehicles, which has limited HEV market penetration. The battery energy storage device is typically the component with the greatest contribution toward this cost increment, so significant cost reductions/performance improvements to the energy storage system (ESS) can improve the vehicle-level cost-benefit relationship, which would in turn lead to larger HEV market penetration and greater aggregate fuel savings. The National Renewable Energy Laboratory (NREL) collaborated with a United States Advanced Battery Consortium (USABC) Workgroup to analyze trade-offs between vehicle fuel economy and reducing the minimum energy requirement for power-assist HEVs. NREL's analysis showed that significant fuel savings could still be delivered from an ESS with much lower energy storage than previous targets, which prompted the United States Advanced Battery Consortium (USABC) to issue a new set of lower-energy ESS (LEESS) targets that could be satisfied by a variety of technologies, including high-power batteries or ultracapacitors. NREL has developed an HEV test platform for in-vehicle performance and fuel economy validation testing of the hybrid system using such LEESS devices. This presentation describes development of the vehicle test platform and in-vehicle evaluation results using a lithium-ion capacitor ESS-an asymmetric electrochemical energy storage device possessing one electrode with battery-type characteristics (lithiated graphite) and one with ultracapacitor-type characteristics (carbon). Further efforts include testing other ultracapacitor technologies in the HEV test platform.

  20. Lean construction management the Toyota way

    CERN Document Server

    Gao, Shang

    2014-01-01

    The book presents a mixed research method adopted to assess and present the Toyota Way practices within construction firms in general and for firms in China specifically. The results of an extensive structured questionnaire survey based on the Toyota Way-styled attributes identified were developed, and data collected from building professionals working in construction firms is presented. The quantitative data presented in the book explains the status quo of the Toyota Way-styled practices implemented in the construction industry, as well as the extent to which these attributes were perceived for lean construction management. The book highlights all the actionable attributes derived from the Toyota Way model appreciated by the building professionals, but alerts the readers that some attributes felled short of implementation. Further findings from in-depth interviews and case studies are also presented in the book to provide to readers an understanding how these Toyota Way practices can be implemented in real-l...

  1. ACT OF IMPLEMENTATION OF TOYOTA SYSTEM

    Directory of Open Access Journals (Sweden)

    Damjan Stanojević

    2013-04-01

    Full Text Available The production system developed by Toyota Motor Corporation was developed to provide best quality, lowest costs, and shortest lead time through the elimination of losts. Kiichiro Toyota, son of Sakichi and founder of the Toyota automobile factory, developed the concept of Just-in-Time in the 1930's. He decreed that by this act Toyota would contain no excess inventory and that Toyota would strive to work both in partnership with suppliers and level production. The Toyota production system has been compared to squeezing water from a dry towel. Importance of Toyota sistem for production proces can sum up on the next way : Reducing costs includung the elimination of waste, With help without warehouse production – elimination the „excess inventory in production“, Reducing time of handwork using maxim „smallest posible of serve“, To reach a production without warehouse – its demand a production in small series, Its not neccessary to produce something else except that you realy need

  2. Development of nickel/metal-hydride batteries for EVs and HEVs

    Science.gov (United States)

    Taniguchi, Akihiro; Fujioka, Noriyuki; Ikoma, Munehisa; Ohta, Akira

    This paper is to introduce the nickel/metal-hydride (Ni/MH) batteries for electric vehicles (EVs) and hybrid electric vehicles (HEVs) developed and mass-produced by our company. EV-95 for EVs enables a vehicle to drive approximately 200 km per charge. As the specific power is extremely high, more than 200 W/kg at 80% depth of discharge (DOD), the acceleration performance is equivalent to that of gasoline fuel automobiles. The life characteristic is also superior. This battery gives the satisfactory result of more than 1000 cycles in bench tests and approximately 4-year on-board driving. EV-28 developed for small EVs comprises of a compact and light battery module with high specific power of 300 W/kg at 80% DOD by introducing a new technology for internal cell connection. Meanwhile, our cylindrical battery for the HEV was adopted into the first generation Toyota Prius in 1997 which is the world's first mass-product HEV, and has a high specific power of 600 W/kg. Its life characteristic was found to be equivalent to more than 100,000 km driving. Furthermore, a new prismatic module in which six cells are connected internally was used for the second generation Prius in 2000. The prismatic battery comprises of a compact and light battery pack with a high specific power of 1000 W/kg, which is approximately 1.7 times that of conventional cylindrical batteries, as a consequence of the development of a new internal cell connection and a new current collection structure.

  3. Frequency of HEV contamination in sewerage waters in Pakistan.

    Science.gov (United States)

    Ahmad, Tahir; Waheed, Yasir; Tahir, Sadia; Safi, Sher Zaman; Fatima, Kaneez; Afzal, Muhammad Sohail; Farooqi, Zia-ur-Rehman; Qadri, Ishtiaq

    2010-12-23

    Enteric viruses, including Hepatitis E virus (HEV), are able to persist under environmental conditions and may cause public health problems by contaminating natural and drinking water resources. Routine procedures for monitoring viruses in water samples have not been established for the water microbiology screening panel. Eighty-six raw sewerage samples were collected from the different regions of Islamabad and Rawalpindi, the twin cities of Pakistan. Samples were concentrated for HEV, using a polyethylene glycol-based method followed by viral RNA extraction using a commercial kit-based method. Reverse transcription polymerase chain reaction (RT-PCR) with HEV specific primers was used for the detection of HEV. The present investigation focused on 86 raw sewerage water samples taken from different locations of drainage outlets of Islamabad and Rawalpindi. After careful experimentation, 35 samples were found to be RT-PCR positive.  Nineteen (44.7%) out of 47 samples from Rawalpindi city were HEV positive while 16 (41.02%) out of 39 samples from Islamabad were HEV positive. All positive samples were found in the highly congested areas. The high detection rate of HEV in this study shows that HEV circulates at a relatively high frequency in the sewerage waters in Pakistan. This study is the first report on detection of HEV from sewerage waste water from Pakistan and suggests that HEV might be a potent indicator of viral pollution in environmental specimens.

  4. Improving Formwork Engineering Using the Toyota Way

    Directory of Open Access Journals (Sweden)

    Jiun-De Kuo

    2011-07-01

    Full Text Available Construction is a labor-intensive industry with formwork engineering requiring a disproportionate amount of labor and costs. Formwork accounts for approximately one-third of the cost of reinforced concrete construction, partly because traditional formwork processes frequently result in delivery delays and material waste. The purpose of this research is to adapt production concepts pioneered by Toyota (the “Toyota Way” to improve formwork engineering. The Toyota Way of production consists of four tiers of management philosophy, known as the “4Ps” model. This research adopts the 4Ps as steps for formwork improvement. The first step, “establishing long term vision,” emphasizes long term considerations for formwork improvement. Step two, “establishing value streams,” reviews formwork flows and eliminates wastage. The third step, “developing the crew,” forms mold workers as a team. The final step is “developing a culture of continuous improvement” that provides a basis for constant review and provides a basis for continuous progress. The present research used the Toyota Way to improve formwork engineering. The improvements include reductions in resource waste and increases in operational value. In the long run, the proposed model could provide a learning and growth platform for individuals, the business unit, and the company’s extended network of partners. It could also serve to spur innovative thinking in the improvement of formwork engineering.

  5. Hepatitis E virus (HEV) genotype 3 infection of human liver chimeric mice as a model for chronic HEV infection

    NARCIS (Netherlands)

    M.D.B. van de Garde (Martijn D.B.); S.D. Pas (Suzan); Van Der Net, G. (Guido); R.A. de Man (Robert); A.D.M.E. Osterhaus (Albert); B.L. Haagmans (Bart); P.A. Boonstra (André); T. Vanwolleghem (Thomas)

    2016-01-01

    textabstractGenotype 3 (gt3) hepatitis E virus (HEV) infections are emerging in Western countries. Immunosuppressed patients are at risk of chronic HEV infection and progressive liver damage, but no adequate model system currently mimics this disease course. Here we explore the possibilities of in

  6. [Assessment of a transfusion emergent risk: the case of HEV].

    Science.gov (United States)

    Pillonel, J; Gallian, P; Sommen, C; Couturier, E; Piquet, Y; Djoudi, R; Laperche, S

    2014-11-01

    The risk assessment for blood transfusion is an essential step that must precede any screening strategy of a pathogen transmitted by transfusion. After several cases of HEV transmission by transfusion in France, a risk assessment for this virus was performed. We used a method based on the prevalence of HEV-RNA in plasmas collected for the preparation of SD-plasma. To estimate the rate of HEV-RNA positive among all blood donations, data on SD-plasma were adjusted on the following HEV risk factors: gender, age group and region of residence. We assumed that HEV risk factors were the same in plasma donors and whole blood donors. Among 57,101 plasma donations tested for HEV-RNA in 2013, 24 were positive (crude rate of 4.2 per 10,000 donations). After adjustment, the total number of HEV-RNA positive blood donations was estimated at 788, accounting for a rate of 2.65 per 10,000 donations (95% CI: 1.6-3.7) or 1 in 3800 donations (1 in 6,200-1 in 2,700). This rate was 12 times higher in men than in women, increased with age, and varied according to region of residence. The risk of blood donation contamination by HEV has been estimated to be 1 in 3800 donations in 2013. An essential input is still missing to assess now the risk in recipients: the minimum infectious dose. Furthermore, the risk in recipients has to be analyzed according to characteristics of transfused patients: presence of anti-HEV immunity, existence of chronic liver disease or immunodeficiency. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  7. Re-lanzamiento del Toyota Corolla

    Directory of Open Access Journals (Sweden)

    José Luis Saavedra Torres

    2010-10-01

    Full Text Available El caso refleja la dinámica de la toma de decisiones corporativas de Toyota Venezuela en el lanzamiento de la novena generación de su modelo Corolla, frente a una situación de expansión del mercado, con caídas en su participación, luego de un largo período como líder. El objetivo es desarrollar una estrategia de posicionamiento acorde con la situación del mercado y la percepción de los consumidores. El estudiante debe someter a discusión las bases de una arquitectura de marca y desarrollar un brief de comunicaciones para el desarrollo de la estrategia de posicionamiento. Se recomienda el retorno a la comunicación más localista, con fuerte énfasis en los valores y el posicionamiento de la marca Toyota.

  8. RE-LANZAMIENTO DEL TOYOTA COROLLA

    Directory of Open Access Journals (Sweden)

    JOSÉ LUIS SAAVEDRA TORRES

    2010-01-01

    Full Text Available El caso refleja la dinámica de la toma de decisiones corporativas de Toyota Venezuela en el lanzamiento de la novena generación de su modelo Corolla, frente a una situación de expansión del mercado, con caídas en su participación, luego de un largo período como líder. El objetivo es desarrollar una estrategia de posicionamiento acorde con la situación del mercado y la percepción de los consumidores. El estudiante debe someter a discusión las bases de una arquitectura de marca y desarrollar un brief de comunicaciones para el desarrollo de la estrategia de posicionamiento. Se recomienda el retorno a la comunicación más localista, con fuerte énfasis en los valores y el posicionamiento de la marca Toyota.

  9. Hev b 11, a peculiar class I chitinase?

    NARCIS (Netherlands)

    Beintema, J. J.

    2007-01-01

    The recently identified rubber allergen Hev b 11, which is a class I chitinase, may be a cytosolic (C-serum) protein. This is a rather unique feature, as all other known plant class I chitinases are vacuolar proteins.

  10. HEV Test Bench Based on CAN Bus Sensor Communication

    Directory of Open Access Journals (Sweden)

    Shupeng ZHAO

    2014-02-01

    Full Text Available The HEV test bench based on Controller Area Network bus was studied and developed. Control system of HEV power test bench used the CAN bus technology. The application of CAN bus technology on control system development has opened up a new research direction for domestic automobile experimental platform. The HEV power control system development work was completed, including power master controller, electric throttle controller, driving simulation platform, CAN2.0 B communication protocol procedures for formulation, CAN communication monitoring system, the simulation model based on MATLAB code automatic generation technology research, etc. Maximum absorption power of the test bench is 90 kW, the test bench top speed is 6000 r/min, the CAN communication data baud rate is 10~500 k, the conventional electric measurement parameter part precision satisfies the requirement of development of HEV. On the HEV test bench the result of regenerative braking experiment shows that the result got by the test bench was closer to the results got by outdoor road test. And the fuel consumption experiment test results show that the HEV fuel consumption and the charge-discharge character are in linear relationship. The establishment of the test platform for the evaluation of the development of hybrid electric vehicle and power provides physical simulation and test platform.

  11. A Recombinant HAV Expressing a Neutralization Epitope of HEV Induces Immune Response against HAV and HEV in Mice.

    Science.gov (United States)

    Xiang, Kui; Kusov, Yuri; Ying, Guan; Yan, Wang; Shan, Yi; Jinyuan, Wu; Na, Yin; Yan, Zhou; Hongjun, Li; Maosheng, Sun

    2017-09-15

    Hepatitis A virus (HAV) and hepatitis E virus (HEV) are causative agents of acute viral hepatitis transmitted via the fecal-oral route. Both viruses place a heavy burden on the public health and economy of developing countries. To test the possibility that HAV could be used as an expression vector for the development of a combination vaccine against hepatitis A and E infections, recombinant HAV-HEp148 was created as a vector to express an HEV neutralization epitope (HEp148) located at aa 459-606 of the HEV capsid protein. The recombinant virus expressed the HEp148 protein in a partially dimerized state in HAV-susceptible cells. Immunization with the HAV-HEp148 virus induced a strong HAV- and HEV-specific immune response in mice. Thus, the present study demonstrates a novel approach to the development of a combined hepatitis A and E vaccine.

  12. Life-cycle private costs of hybrid electric vehicles in the current Chinese market

    International Nuclear Information System (INIS)

    Lin, Chengtao; Wu, Tian; Ou, Xunmin; Zhang, Qian; Zhang, Xu; Zhang, Xiliang

    2013-01-01

    Understanding the life-cycle private cost (LCPC) of the hybrid electric vehicle (HEV) is important for market feasibility analysis. An HEV LCPC model was established to evaluate HEV market prospects in China compared with traditional internal combustion engine vehicles (ICEV). The Kluger HV, a full-hybrid HEV sports utility vehicle (SUV), aimed at the Chinese market, was simulated as the 2010 model's technology details were well publicized. The LCPC of the Kluger HV was roughly the same (about 1.06 times) as that of its comparable ICEV (Highlander SUV). This aligns with other compact and midsize HEV cars (e.g., Toyota Prius, Honda Civic and Toyota Camry HEV) in China. With oil prices predicted to rise in the long-term, the advantage of HEVs energy saving will partly compensate the high manufacturing costs associated with their additional motor/battery components. Besides supporting technology development, enabling policy should be implemented to introduce HEV technology into taxi fleets and business cars. This technology's cost-competitiveness, compared with traditional ICEVs, is advantageous for these higher mileage vehicles. - Highlights: ► A model is set up to evaluate the life-cycle private cost of HEVs. ► Life-cycle private costs of HEVs are higher than conventional cars in China. ► HEVs become competitive when the oil price rises

  13. Septembri müüghitt oli Toyota / Tõnu Tramm

    Index Scriptorium Estoniae

    Tramm, Tõnu, 1968-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti 13. okt. lk. 12. Ülevaade septembrikuu automüügistatistikast. Tabelid: Toyota müük kasvanud viiendiku võrra; Toyota Corolla septembris ostjate lemmik. Vt. samas: Tartus jätkub Volkswageni-hullus

  14. An Evaluability Assessment of the Toyota Families in Schools Program.

    Science.gov (United States)

    Quint, Janet

    The Toyota Families in Schools (TFS) Program is a new family literacy initiative that was developed by the National Center for Family Literacy (NCFL) with support from the Toyota Motor Corporation. TFS is based on a previous NCFL model calling for providing literacy activities to preschoolers and parents from low-income families. NCFL wanted to…

  15. Maintenance of Cruising (Set Speed) Control System of TOYOTA CAMRY CAR%丰田佳美轿车巡航(定速)控制系统的维修

    Institute of Scientific and Technical Information of China (English)

    戴冠军

    2000-01-01

    介绍了日本丰田佳美轿车巡航(定速)控制系统的结构与原理.该系统通常具有巡航(定速)、惯性滑行、恢复车速、加速及点动增(减)速等功能.阐述了该系统代码故障的维修及未显示故障代码但有故障症状时的维修.

  16. PEFC R&D technology at Toyota

    Energy Technology Data Exchange (ETDEWEB)

    Kawatsu, Shigeyuki; Aoyama, Satoshi; Iwase, Masayoshi [Toyota Motor Corp., Shizuoka (Japan)

    1996-12-31

    Fuel cells are being considered as notable new energy sources due to, not only their potential for obtaining high energy conversion efficiencies, but also their environmental sensitive features. These are especially important now that the problems relating to global environmental pollution are regarded as serious social issues. Polymer electrolyte fuel cells (PEFCs) in particular are being pursued due in part to the prospect of realizing timely enhancements to several key characteristics, including size and power. Encouraged by these anticipated improvements, PEFCs are being investigated as promising power generator candidates for hybrid electric vehicles. The substantial future potential of PEFCs has been noted by TOYOTA, and has motivated extensive R&D activities toward the practical application of PEFCs to hybrid electric vehicles. These R&D efforts include, not only activities on such key areas as performance enhancement, but also extensive attention to a broad range of related concerns, such as cost reduction, reformer development, system integration, durability, reliability and so on. From these diverse tasks, this paper focuses on the issues related to ensuring adequate PEFC performance when reformed fuel is utilized. Recent outcomes of R&D conducted at TOYOTA on this topic will be described.

  17. Innovative development methodology based on the Toyota Way; Innovative Entwicklungsmethodik basierend auf dem Toyota Way

    Energy Technology Data Exchange (ETDEWEB)

    Ueda, T. [Toyota Motor Corp., Aichi (Japan)

    2007-07-01

    Since its foundation, Toyota has been innovating in each process of automobile production based on the ideas shown in the Toyoda Precepts. These innovations are not only innovations in the methodology for various development processes, but also in company philosophy models cultivated by development engineers during their daily job. These are known as the ''Toyota Way'' and its elements which include ''Continuous Improvement'', ''Challenge'', ''Respect for People'', ''Genchi Genbutsu'' and ''Teamwork''. Various technological innovations have already progressed in the process from engine development to production. Examples are the use of CAD (computer aided design) and structure analysis based on 3-D CAD data in hardware development, CFD (computational fluid dynamics) and visualization techniques in combustion system development, MBD (model based development), the related DOE (design of engineering) and new algorithms in software development, as well as new production strategies linked to the new techniques mentioned above. The development of Toyota's direct injection gasoline engine (Toyota D-4 engine) originated from a pre-combustion chamber system in the 1970's with the aim of purifying the exhaust gases when the future of catalyst technology was unpromising. This technology could not be mass-produced, but could subsequently go on to the, R and D of DISC (direct injection stratified charge). In 1996, the stratified charge lean combustion gasoline DI engine could then be launched as the first-generation Toyota D-4 engine. After the second-generation D-4 engine was developed, this technology has now acceded to the dual injection D-4 system (D-4S), which combines it with homogeneous charged stoichiometric combustion and port fuel injection. During this progress, innovative development methods have been used and improvements in production

  18. Pengaruh Brand Identity Terhadap Timbulnya Brand Preference Dan Repurchase Intention Pada Merek Toyota

    OpenAIRE

    Halim, Beatrice Clementia

    2014-01-01

    Penelitian ini dilakukan untuk mengetahui pengaruh identitas merk Toyota terhadap timbulnya preferensi merek dan niat pembelian kembali konsumen terhadap merek Toyota. Toyota sebagai penguasa pasar mobil di Indonesia, memiliki keunggulan kompetitif tersendiri dibandingkan dengan pesaingnya. Kepercayaan terhadap merek Toyota juga menimbulkan adanya niat pembelian kembali konsumen terhadap merek tersebut.Teknik analisa yang digunakan dalam penelitian ini adalah kausal asosiatif dengan metode pe...

  19. 77 FR 4396 - Petition for Exemption From the Federal Motor Vehicle Motor Theft Prevention Standard; Toyota

    Science.gov (United States)

    2012-01-27

    ... From the Federal Motor Vehicle Motor Theft Prevention Standard; Toyota AGENCY: National Highway Traffic... exemption. SUMMARY: This document grants in full the petition of Toyota Motor North America, Inc's., (Toyota.... SUPPLEMENTARY INFORMATION: In a petition dated September 30, 2011, Toyota requested an exemption from the parts...

  20. 78 FR 3081 - Petition for Exemption From the Federal Motor Vehicle Motor Theft Prevention Standard; Toyota

    Science.gov (United States)

    2013-01-15

    ... From the Federal Motor Vehicle Motor Theft Prevention Standard; Toyota AGENCY: National Highway Traffic.... SUMMARY: This document grants in full Toyota Motor North America, Inc.'s (Toyota) petition for an... a petition dated October 16, 2012, Toyota requested an exemption from the parts-marking requirements...

  1. 76 FR 12221 - Petition for Exemption From the Federal Motor Vehicle Motor Theft Prevention Standard; Toyota

    Science.gov (United States)

    2011-03-04

    ... From the Federal Motor Vehicle Motor Theft Prevention Standard; Toyota AGENCY: National Highway Traffic.... SUMMARY: This document grants in full the petition of Toyota Motor North America, Inc's., (Toyota... INFORMATION: In a petition dated January 24, 2011, Toyota requested an exemption from the parts-marking...

  2. Subcellular localization of hepatitis E virus (HEV) replicase

    International Nuclear Information System (INIS)

    Rehman, Shagufta; Kapur, Neeraj; Durgapal, Hemlata; Panda, Subrat Kumar

    2008-01-01

    Hepatitis E virus (HEV) is a hepatotropic virus with a single sense-strand RNA genome of ∼ 7.2 kb in length. Details of the intracellular site of HEV replication can pave further understanding of HEV biology. In-frame fusion construct of functionally active replicase-enhanced green fluorescent protein (EGFP) gene was made in eukaryotic expression vector. The functionality of replicase-EGFP fusion protein was established by its ability to synthesize negative-strand viral RNA in vivo, by strand-specific anchored RT-PCR and molecular beacon binding. Subcellular co-localization was carried out using organelle specific fluorophores and by immuno-electron microscopy. Fluorescence Resonance Energy Transfer (FRET) demonstrated the interaction of this protein with the 3' end of HEV genome. The results show localization of replicase on the endoplasmic reticulum membranes. The protein regions responsible for membrane localization was predicted and identified by use of deletion mutants. Endoplasmic reticulum was identified as the site of replicase localization and possible site of replication

  3. seroprevalence of hav, hbv, hcv, and hev among acute hepatitis

    African Journals Online (AJOL)

    2013-07-30

    =1); IgM anti-HBc and IgM anti-HEV 1% (n=1); IgM anti-HBc and ... Viral hepatitis is a recognised major public health ... of HBV carriers varies substantially between regions, ... standards of sanitation promote the transmission.

  4. Analisis Pangsa Pasar Mobil Toyota Avanza Di Kutai Timur

    OpenAIRE

    Mardiana, Edy Fatmaraga, Theresia Militina

    2016-01-01

    The purpose of this study is to determine the market share of car brands Toyota Avanza and knowing the type of the largest market share in 2013 in East Kutai.The results of this study stated hypothesis proposed that "alleged that the market share of car brands Toyota Avanza types from January to December in 2013 is larger than its competitors in the East Kutai Regency" is denied, the reason for this hypothesis is rejected Car Market Share brands Toyota types Avanza from January to December of...

  5. A New Hybrid Power Configuration Used In HEV And Development of Its Driving BLDC

    Directory of Open Access Journals (Sweden)

    Yanliang Xu

    2013-07-01

    Full Text Available Hybrid electric vehicle (HEV that has the advantages of high performance, high fuel efficiency, low emissions, and long operating range is focused on nowadays. A new hybrid power configuration used in HEV is presented with different control strategies and HEV performances when equipping different weight of fuel power and battery one. In order to realize the new hybrid power configuration especially in the refitted HEV, fractional-slot concentrated-wingding BLDC with higher rated spinning speed is given and the prototyped one is developed and fabricated which satisfy successfully the requirements of high performance and demission restriction for the refitted HEV.

  6. Estimation of hepatitis E virus (HEV) pig seroprevalence using Elisa and Western blot and comparison between human and pig HEV sequences in Belgium.

    NARCIS (Netherlands)

    Thiry, D.; Mauroy, A.; Saegerman, C.; Thomas, I.; Wautier, M.; Miry, C.; Czaplicki, G.; Berkvens, D.; Praet, N.; Poel, van der W.H.M.; Cariolet, R.; Brochier, B.; Thiry, E.

    2014-01-01

    Zoonotic transmission of hepatitis E virus (HEV) is of special concern, particularly in high income countries were waterborne infections are less frequent than in developing countries. High HEV seroprevalences can be found in European pig populations. The aims of this study were to obtain prevalence

  7. Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4

    OpenAIRE

    An, Junqing; Liu, Tianlong; She, Ruiping; Wu, Qiaoxing; Tian, Jijing; Shi, Ruihan; Hao, Wenzhuo; Ren, Xinxin; Yang, Yue; Lu, Yiyao; Yang, Yifei; Wu, Yuanheng

    2017-01-01

    Hepatitis E virus (HEV) infection can induce infertility and miscarriage in pregnant women and infect neonates through vertical transmission. However, the mechanism of infertility and vertical transmission remains unclear. In the present study, we evaluated the replication of HEV in the ovary and structural and molecular changes induced by HEV after intraperitoneal injection of HEV in rabbits. Positive- and negative-strand HEV RNA was detected in the ovaries at 28 and 49 days post-infection. ...

  8. HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients.

    Science.gov (United States)

    Westhölter, Dirk; Hiller, Jens; Denzer, Ulrike; Polywka, Susanne; Ayuk, Francis; Rybczynski, Meike; Horvatits, Thomas; Gundlach, Svantje; Blöcker, Johanna; Schulze Zur Wiesch, Julian; Fischer, Nicole; Addo, Marylyn M; Peine, Sven; Göke, Burkhard; Lohse, Ansgar W; Lütgehetmann, Marc; Pischke, Sven

    2018-03-15

    Routine HEV testing of blood products has recently been implemented in Great Britain and the Netherlands. The relevance of transfusion-transmitted HEV infections is still controversially discussed in Europe. All blood donations at the University Medical Center Hamburg-Eppendorf were prospectively tested for HEV RNA by pooled PCR from October 2016 to May 2017. Reactive samples were individually retested. Additionally, stored samples from previous donations of positive donors were tested to determine the duration of HEV viraemia. HEV RNA-positive donors and a control cohort were asked to answer a questionnaire. Twenty-three out of 18,737 HEV RNA-positive donors were identified (0.12%). Only two of the positive donors (8.7%) presented with elevated aminotransferases at time of donation (alanine aminotransferase: 192 and 101 U/L). The retrospective analysis of all positive donors revealed that four asymptomatic donors had been HEV viraemic for up to three months with the longest duration of HEV viraemia exceeding four months. Despite the HEV-testing efforts, 14 HEV RNA-positive blood products were transfused into 12 immunocompromised and two immunocompetent patients. One recipient of these products developed fatal acute-on-chronic liver failure complicated by Pseudomonas septicemia. The questionnaire revealed that HEV RNA-positive donors significantly more often consumed raw pork meat (12 out of 18; 67%) than controls (89 out of 256; 35%; p = 0.01). In two donors, undercooked pork liver dishes were identified as the source of infection. HEV genotyping was possible in 7 out of 23 of HEV viraemic donors and six out of seven isolates belonged to HEV Genotype 3, Group 2. Prolonged HEV viraemia can be detected at a relatively high rate in Northern German blood donors, leading to transfusion-transmitted HEV infections in several patients with the risk of severe and fatal complications. Eating raw pork tartare represented a relevant risk for the acquisition of HEV

  9. "The Toyota Way". LEAN, more than a kit of tools and techniques

    OpenAIRE

    SERGIO JULIÁN GARCÍA; ASIER TOLEDANO DE DIEGO; NAGORE MAÑES SIERRA

    2009-01-01

    When speaking about LEAN, people immediately think about Toyota and its continuous success. Accordingly, many companies have tried to follow its model: the TPS (Toyota Production System) or the LEAN model, based on it. However, few ones have achieved it. We think the book «The Toyota way» gives the answer through fourteen principles that we are commenting in this article.

  10. Analisis Faktor Pembentuk Ekuitas Merek Toyota dan Daihatsu di Indonesia (Studi Komparasi pada Masyarakat Bandung)

    OpenAIRE

    Sigiro, Cristine Afriani; Rachma Putri, Yuliani; Ilfandy Imran, Ayub

    2016-01-01

    Toyota dan Daihatsu merupakan dua merek otomotif (mobil) yang sangat fenomenal di kalangan masyarakat Indonesia. Produk dari kedua merek tersebut memiliki persamaan yang identik, namun Toyota memasarkan produknya lebih mahal dibandingkan Daihatsu. Tujuan penelitian ini untuk mengetahui perbandingan ekuitas merek Toyota dan Daihatsu menurut masyarakat Bandung. Penelitian ini menggunakan paradigma penelitian positivistik dengan metode penelitian studi komparatif melalui teknik analisis data yan...

  11. Toyota production system beyond large-scale production

    CERN Document Server

    Ohno, Taiichi

    1998-01-01

    In this classic text, Taiichi Ohno--inventor of the Toyota Production System and Lean manufacturing--shares the genius that sets him apart as one of the most disciplined and creative thinkers of our time. Combining his candid insights with a rigorous analysis of Toyota's attempts at Lean production, Ohno's book explains how Lean principles can improve any production endeavor. A historical and philosophical description of just-in-time and Lean manufacturing, this work is a must read for all students of human progress. On a more practical level, it continues to provide inspiration and instruction for those seeking to improve efficiency through the elimination of waste.

  12. Optical projection tomography reveals dynamics of HEV growth after immunization with protein plus CFA and features shared with HEVs in acute autoinflammatory lymphadenopathy.

    Science.gov (United States)

    Kumar, Varsha; Chyou, Susan; Stein, Jens V; Lu, Theresa T

    2012-01-01

    The vascular-stromal compartment of lymph nodes is important for lymph node function, and high endothelial venules (HEVs) play a critical role in controlling the entry of recirculating lymphocytes. In autoimmune and autoinflammatory diseases, lymph node swelling is often accompanied by apparent HEV expansion and, potentially, targeting HEV expansion could be used therapeutically to limit autoimmunity. In previous studies using mostly flow cytometry analysis, we defined three differentially regulated phases of lymph node vascular-stromal growth: initiation, expansion, and the re-establishment of vascular quiescence and stabilization. In this study, we use optical projection tomography to better understand the morphologic aspects of HEV growth upon immunization with ovalbumin/CFA (OVA/CFA). We find HEV elongation as well as modest arborization during the initiation phase, increased arborization during the expansion phase, and, finally, vessel narrowing during the re-establishment of vascular quiescence and stabilization. We also examine acutely enlarged autoinflammatory lymph nodes induced by regulatory T cell depletion and show that HEVs are expanded and morphologically similar to the expanded HEVs in OVA/CFA-stimulated lymph nodes. These results reinforce the idea of differentially regulated, distinct phases of vascular-stromal growth after immunization and suggest that insights gained from studying immunization-induced lymph node vascular growth may help to understand how the lymph node vascular-stromal compartment could be therapeutically targeted in autoimmune and autoinflammatory diseases.

  13. Optical projection tomography reveals dynamics of HEV growth after immunization with protein plus CFA and features shared with HEVs in acute autoinflammatory lymphadenopathy

    Directory of Open Access Journals (Sweden)

    Varsha eKumar

    2012-09-01

    Full Text Available The vascular-stromal compartment of lymph nodes is important for lymph node function, and high endothelial venules (HEVs play a critical role in controlling the entry of recirculating lymphocytes. In autoimmune and autoinflammatory diseases, lymph node swelling is often accompanied by apparent HEV expansion and, potentially, targeting HEV expansion could be used therapeutically to limit autoimmunity. In previous studies using mostly flow cytometry analysis, we defined 3 differentially regulated phases of lymph node vascular-stromal growth: initiation, expansion, and the re-establishment of vascular quiescence and stabilization. In this study, we use optical projection tomography to better understand the morphologic aspects of HEV growth upon immunization with ovalbumin/CFA. We find HEV elongation as well as modest arborization during the initiation phase, increased arborization during the expansion phase, and, finally, vessel narrowing during the re-establishment of vascular quiescence and stabilization. We also examine acutely enlarged autoinflammatory lymph nodes induced by regulatory T cell depletion and show that HEVs are expanded and morphologically similar to the expanded HEVs in OVA/CFA-stimulated lymph nodes. These results reinforce the idea of differentially regulated, distinct phases of vascular-stromal growth after immunization and suggest that insights gained from studying immunization-induced lymph node vascular growth may help to understand how the lymph node vascular-stromal compartment could be therapeutically targeted in autoimmune and autoinflammatory diseases.

  14. 76 FR 78043 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Toyota Motor...

    Science.gov (United States)

    2011-12-15

    ... Production Act of 1993--Toyota Motor Corporation and Ford Motor Company Collaboration Notice is hereby given... Ford Motor Company Collaboration (``Toyota and Ford'') has filed written notifications simultaneously... venture are: Toyota Motor Corporation, Toyota City, JAPAN; and Ford Motor Company, Dearborn, MI. The...

  15. Using Toyota's A3 Thinking for Analyzing MBA Business Cases

    Science.gov (United States)

    Anderson, Joe S.; Morgan, James N.; Williams, Susan K.

    2011-01-01

    A3 Thinking is fundamental to Toyota's benchmark management philosophy and to their lean production system. It is used to solve problems, gain agreement, mentor team members, and lead organizational improvements. A structured problem-solving approach, A3 Thinking builds improvement opportunities through experience. We used "The Toyota…

  16. Development of Traction Drive Motors for the Toyota Hybrid System

    Science.gov (United States)

    Kamiya, Munehiro

    Toyota Motor Corporation developed in 2005 a new hybrid system for a large SUV. This system included the new development of a high-speed traction drive motor achieving a significant increase in power weight ratio. This paper provides an overview of the hybrid system, discusses the characteristics required of a traction drive motor, and presents the technologies employed in the developed motor.

  17. Renault ja Toyota - mullused turuvõitjad / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2005-01-01

    Enam müüdavatest sõiduautodest Eestis aastal 2004. Diagrammid. Tabelid: Toyota edu teiste ees mäe kõrgune; Kõige edukam oli 2004. aasta Renault müüjatele; Saksa ja Jaapani autode müük kasvas enim. Vt. samas: Tõnu Tramm. Euroliit tekitas eelmise aasta kevadel müügibuumi

  18. Logic Model Checking of Unintended Acceleration Claims in Toyota Vehicles

    Science.gov (United States)

    Gamble, Ed

    2012-01-01

    Part of the US Department of Transportation investigation of Toyota sudden unintended acceleration (SUA) involved analysis of the throttle control software, JPL Laboratory for Reliable Software applied several techniques including static analysis and logic model checking, to the software; A handful of logic models were build, Some weaknesses were identified; however, no cause for SUA was found; The full NASA report includes numerous other analyses

  19. Toyota production system - one example to shipbuilding industry

    OpenAIRE

    Delmo Alves de Moura; Rui Carlos Botter

    2017-01-01

    The shipbuilding system can use the techniques used in the Toyota Production System as an example for its production process. Production should be lean, minimize defects, stop production and reduce or eliminate inventories. Lean production is regarded by many as simply an enhancement of mass production methods, whereas agility implies breaking out of the mass production mould and producing much more highly customized products - where the customer wants them in any quantity. In a product line ...

  20. Pengaruh Citra Merek dan Terpaan Iklan terhadap Keputusan Pembelian Toyota Yaris di Kota Semarang

    OpenAIRE

    Putri, Annisya Winarni; Pradekso, Tandiyo; Herieningsih, Sri Widowati; Rakhmad, Wiwid Noor

    2016-01-01

    Selama tujuh tahun terakhir, penjualan otomotif di Indonesia naik hampir empat kali lipatatau 286%. Para produsen mobil terus melakukan inovasi terhadap produknya. Hal ini terlihatdari semakin beraneka ragamnya merek dan jenis mobil di Indonesia. Toyota, sebagai salah satupabrik otomotif terbesar di Indonesia meluncurkan beberapa jenis mobil. Pada kategorihatchback, PT. Toyota Astra Motor mengeluarkan beberapa jenis produk yaitu Toyota Yaris.Sebagai produk yang diunggulkan di kelasnya, tentun...

  1. Pengaruh Kualitas Pelayanan Dan Kepuasan Konsumen Terhadap Loyalitas Konsumen PT. Toyota Astra Financial Service Medan

    OpenAIRE

    Purba, Nona Erika

    2012-01-01

    Formulation of the problem in this study is to what extent the influence of service quality: reliability, responsiveness, assurance, empathy and physical evidence of customer satisfaction PT. Toyota Astra Financial Service Field, the influence of customer satisfaction on consumer loyalty PT. Toyota Astra Financial Service Field and the influence of service quality and customer satisfaction to customer loyalty PT. Toyota Astra Financial Service Field. The purpose of this study is to investigat...

  2. Pengembangan Value Proposition Dalam Penetapan Strategi Pemasaran (Studi Kasus Terhadap Mobil Toyota Agya Di Kota Malang)

    OpenAIRE

    Andaru, Rizka Kurnia

    2015-01-01

    This research aims to knowing value proposition that is offered on Toyota Agya, knowing consumer perceptions about value proposition of toyota agya in Malang City, and knowing the development of value proposition in determining the marketing strategy at Toyota Agya in Malang City. The data source of research were informant, documents, places and events. Analysis of the data used interactive data analysis. The results showed that 11 elements of Value proposition according to Alexander Osterwal...

  3. Pengaruh Marketing Mix Terhadap Keputusan Pembelian Toyota Avanza Tipe G Di Surabaya

    OpenAIRE

    Setiawan, Wilson

    2014-01-01

    This research aims to analyze the impact of elemen's marketing mix such as product, price, place and promotion to Purchase Decision Toyota Avanza Type G at Surabaya. And then, between four element of marketing mix, the dominant element's of marketing to affect Purchase Decision Toyota Avanza type G at Surabaya. This research was conducting by distributing questionnaires to 100 consumers of Toyota Avanza type G. Analysis tool used to measure the impact of Marketing Mix to Purchase Decisionis ...

  4. Analisis Pelaksanaan Strategi Positioning pada Produk Toyota Avanza (Kasus Penjualan Toyota Avanza pada PT. Agung Automall Pekanbaru)

    OpenAIRE

    Andri, Seno; Rinaldi, Oki

    2015-01-01

    PT. Agung Automall Sutomo Pekanbaru branch is one of Toyota dealers in Pekanbaru is located at Jl. Sutomo 13 Pekanbaru. PT Agung Automall Sutomo Pekanbaru branch charged with marketing activities for the products produced. Marketing includes the companys business that starts with identifying consumers needs should be satisfied, determine the products to be manufactured, determine appropriate product prices, determine ways of promotion and distribution / sale of such products, and eventually t...

  5. KAJIAN DESAIN TOYOTA KIJANG DAN PENGUATAN CITRA PADA MASYARAKAT SOLO

    Directory of Open Access Journals (Sweden)

    Satriana Didiek Isnanta

    2007-01-01

    Full Text Available Indonesia's modern consumer societies develop in conjunction with the history of global economy and the transformation of consumer capitalism. This happens in many communities in cities of Indonesia, including Solo. With a population of 500 thousand at night and 1.5 million during the day, it is a potential market for global products. Therefore, it is obvious if the Solo people's tastes are no different than other communities, because of the consumer behaviour and global economy that are intertwined. The value of the meaning of products have also shifted, such as with cars. Cars that usually function as a vehicle no different than a wagon, have changed into a symbol of social class for the modern society, even for the people of Solo. The functions and facilities of the Various brands and types of cars, and elements that are related to automotive technology, are not too different. What makes the difference between these cars lays on the design of the form and image. This form design is able to create an image for certain social class for its user and its product brand. The most interesting phenomenon from automotive products in Indonesia is what happened with Toyota Kijang. Since its launch on 1977, Toyota Kijang, which is on its fifth generation this year, has succeeded in becoming the number one choice for cars for Indonesians. Abstract in Bahasa Indonesia: Masyarakat konsumen Indonesia mutakhir tumbuh beriringan dengan sejarah globalisasi ekonomi dan transformasi kapitalisme konsumsi Hal ini terjadi di banyak masyarakat perkotaan Indonesia termasuk masyarakat kota Solo. Dengan jumlah penduduk sebesar 500 ribu jiwa pada malam hari dan 1,5 juta jiwa pada siang hari merupakan pasar potensial bagi produk-produk global, maka tidak mengherankan bila selera masyarakat Solo sekarang tidak ubahnya dengan selera masyarakat lain karena perilaku konsumtif dan globalisasi ekonomi sangat terkait. Dalam menilai sebuah makna produkpun juga telah bergeser, tak

  6. Systemic antibody response to nano-size calcium phospate biocompatible adjuvant adsorbed HEV-71 killed vaccine

    OpenAIRE

    Saeed, Mohamed Ibrahim; Omar, Abd Rahaman; Hussein, Mohd Zobir; Elkhidir, Isam Mohamed; Sekawi, Zamberi

    2015-01-01

    Purpose Since 1980s, human enterovirus-71 virus (HEV-71) is one of the common infectious disease in Asian Pacific region since late 1970s without effective commercial antiviral or protective vaccine is unavailable yet. The work examines the role of vaccine adjuvant particle size and the route of administration on postvaccination antibody response towards HEV-71 vaccine adsorbed to calcium phosphate (CaP) adjuvant. Materials and Methods First, CaP nano-particles were compared to a commercial m...

  7. Why is the market for hybrid electric vehicles (HEVs) moving slowly?

    Science.gov (United States)

    Rahmani, Djamel; Loureiro, Maria L

    2018-01-01

    Hybrid electric vehicles (HEVs) could be a good short term option to help achieve global targets regarding road transport greenhouse gas emissions. Several common and country-specific public policies based on price or tax rebates are established in order to encourage the adoption of HEVs. The present research empirically assesses market preferences for HEVs in Spain, looking at the role of subsidies. An interactive internet-based survey was conducted in a representative sample (N = 1,200) of Spanish drivers. Drivers are willing to pay an extra amount of €1,645 for a HEV model compared to a conventional vehicle, premium which is well below the price markup for these cars. Therefore, current levels of economic subsidies applied in isolation to promote these types of vehicles may have a quite limited effect in extending their use. Overall, it is found that drivers have clear misconceptions about HEVs, which affect their purchasing choices and perceptions. Therefore, a policy mix of various incentives (including informational campaigns) may be required in order to stimulate the demand for HEVs.

  8. Why is the market for hybrid electric vehicles (HEVs) moving slowly?

    Science.gov (United States)

    Rahmani, Djamel; Loureiro, Maria L.

    2018-01-01

    Hybrid electric vehicles (HEVs) could be a good short term option to help achieve global targets regarding road transport greenhouse gas emissions. Several common and country-specific public policies based on price or tax rebates are established in order to encourage the adoption of HEVs. The present research empirically assesses market preferences for HEVs in Spain, looking at the role of subsidies. An interactive internet-based survey was conducted in a representative sample (N = 1,200) of Spanish drivers. Drivers are willing to pay an extra amount of €1,645 for a HEV model compared to a conventional vehicle, premium which is well below the price markup for these cars. Therefore, current levels of economic subsidies applied in isolation to promote these types of vehicles may have a quite limited effect in extending their use. Overall, it is found that drivers have clear misconceptions about HEVs, which affect their purchasing choices and perceptions. Therefore, a policy mix of various incentives (including informational campaigns) may be required in order to stimulate the demand for HEVs. PMID:29561860

  9. Optimal energy management of HEVs with hybrid storage system

    International Nuclear Information System (INIS)

    Vinot, E.; Trigui, R.

    2013-01-01

    Highlights: • A battery and ultra-capacitor system for parallel hybrid vehicle is considered. • Optimal management using Pontryagin’s minimum principle is developed. • Battery stress limitation is taken into account by means of RMS current. • Rule based management approaching the optimal control is proposed. • Comparison between rule based and optimal management are proposed using Pareto front. - Abstract: Energy storage systems are a key point in the design and development of electric and hybrid vehicles. In order to reduce the battery size and its current stress, a hybrid storage system, where a battery is coupled with an electrical double-layer capacitor (EDLC) is considered in this paper. The energy management of such a configuration is not obvious and the optimal operation concerning the energy consumption and battery RMS current has to be identified. Most of the past work on the optimal energy management of HEVs only considered one additional power source. In this paper, the control of a hybrid vehicle with a hybrid storage system (HSS), where two additional power sources are used, is presented. Applying the Pontryagin’s minimum principle, an optimal energy management strategy is found and compared to a rule-based parameterized control strategy. Simulation results are shown and discussed. Applied on a small compact car, optimal and ruled-based methods show that gains of fuel consumption and/or a battery RMS current higher than 15% may be obtained. The paper also proves that a well tuned rule-based algorithm presents rather good performances when compared to the optimal strategy and remains relevant for different driving cycles. This rule-based algorithm may easily be implemented in a vehicle prototype or in an HIL test bench

  10. Pengaruh Citra Merek (Brand Image) Dan Kepercayaan Merek (Brand Trust) Terhadap Keputusan Toyota Avanza Di Kota Semarang

    OpenAIRE

    Trista, Nadia Lona; prihatini, Apriatni Endang; Saryadi, Saryadi

    2013-01-01

    Toyota is an automotive company that manufactures Toyota Avanza. There are several motives in buying the Toyota Avanza, one of which is the image of the brand. But, in the city of Semarang instability sales volume of Toyota Avanza. The purpose of this study was to determine the effect of brand image and brand trust on purchase decisions. The sampling technique used nonprobability sampling technique, purpose accidental sampling and purposive sampling-judgment sampling with a sample size of 100...

  11. ANALISIS PENERAPAN STRATEGI PEMASARAN DALAM PENINGKATAN PANGSA PASAR PADA PT. HADJI KALLA (TOYOTA) CABANG COKROAMINOTO DI MAKASSAR

    OpenAIRE

    ASTRINI, PRATANTI AYU

    2007-01-01

    Analisis Penerapan Strategi Pemasaran Dalam Peningkatan Pangsa Pasar Pada PT. Hadji Kalla (Toyota) Cabang Cokroaminoto di Makassar Implementation of marketing strategy analyze on increasing market share study case PT.Hadji Kalla (Toyota) Cabang Cokroaminoto in Makassar Pratanti Ayu Astrini Mursalim Nohong Wardhani Hakim Tujuan dari penelitian ini adalah untuk mengetahui penerapan strategi pemasaran mobil Toyota pada PT. Hadji Kalla (Toyota) Cabang Cokroaminoto di Makassar me...

  12. A comparative study and analysis of an optimized control strategy for the toyota hybrid system

    NARCIS (Netherlands)

    Hofman, Theo; Purnot, Thijs

    2009-01-01

    The Toyota Prius equipped with the Toyota Hybrid System (THS) II vehicle uses a combination of a combustion engine and two electric machines in order to increase the efficiency and the fuel economy. The Energy Management Strategy (EMS) of the THS II is analyzed using measurement data collected with

  13. Strategi Pemasaran Komunitas And Implikasinya Pada Loyalitas Merek Toyota Di Indonesia [Community Marketing Strategy and Its Implication on Brand Loyalty Toyota in Indonesia

    Directory of Open Access Journals (Sweden)

    Aditya Wardhana

    2016-10-01

    Full Text Available This research study examined the strategic community marketing and its impact on brand loyalty of Toyota in Indonesia. Elements of the strategic community marketing were: (a critical awareness and reflection, (b building community identity, political and legislative actions, (c culturally relevant practice, (d spontaneous associations of neighbors, colleagues, or groups with a particular interest in a topic, (e leadership in communities; (f empowerment; and (g critical reflection. Elements of the brand loyalty were: perceived risk, inertia, habit, involvement, satisfaction, and relationship between product or service providers. The population of this study was 4,000 customers from 29 Toyota communities in Indonesia who used Toyota cars. The size of the sample was 400 respondents. The sampling method used nonprobability sampling by incidental sampling. The results by using structural equation modeling (SEM found significant impacts of strategic marketing community on brand loyalty of Toyota in Indonesia.

  14. 77 FR 20485 - Notice of Receipt of Petition for Decision That Nonconforming 1999 to 2006 Toyota Land Cruiser...

    Science.gov (United States)

    2012-04-04

    ...-0035, Notice 1] Notice of Receipt of Petition for Decision That Nonconforming 1999 to 2006 Toyota Land... Administration (NHTSA) of a petition for a decision that nonconforming 1999 to 2006 Toyota Land Cruiser IFS 100... manufacturer as complying with the safety standards (the U.S.-certified version of the 1999 to 2006 Toyota Land...

  15. Lean Management—The Journey from Toyota to Healthcare

    Directory of Open Access Journals (Sweden)

    Sorin T. Teich

    2013-04-01

    Full Text Available The evolution of production systems is tightly linked to the story of Toyota Motor Company (TMC that has its roots around 1918. The term “lean” was coined in 1990 following the exploration of the Toyota model that led to the “transference” thesis sustaining the concept that manufacturing problems and technologies are universal problems faced by management and that these concepts can be emulated in non-Japanese enterprises. Lean is a multi-faceted concept and requires organizations to exert effort along several dimensions simultaneously; some consider a successful implementation either achieving major strategic components of lean, implementing practices to support operational aspects, or providing evidence that the improvements are sustainable in the long term. The article explores challenges and opportunities faced by organizations that intend incorporating lean management principles and presents the specific context of the healthcare industry. Finally, the concepts of “essential few” and customer value are illustrated through a simple example of process change following lean principles, which was implemented in a dental school in the United States.

  16. Lean Management—The Journey from Toyota to Healthcare

    Science.gov (United States)

    Teich, Sorin T.; Faddoul, Fady F.

    2013-01-01

    The evolution of production systems is tightly linked to the story of Toyota Motor Company (TMC) that has its roots around 1918. The term “lean” was coined in 1990 following the exploration of the Toyota model that led to the “transference” thesis sustaining the concept that manufacturing problems and technologies are universal problems faced by management and that these concepts can be emulated in non-Japanese enterprises. Lean is a multi-faceted concept and requires organizations to exert effort along several dimensions simultaneously; some consider a successful implementation either achieving major strategic components of lean, implementing practices to support operational aspects, or providing evidence that the improvements are sustainable in the long term. The article explores challenges and opportunities faced by organizations that intend incorporating lean management principles and presents the specific context of the healthcare industry. Finally, the concepts of “essential few” and customer value are illustrated through a simple example of process change following lean principles, which was implemented in a dental school in the United States. PMID:23908857

  17. Present state of applying diode laser in Toyota Motor Corp.

    Science.gov (United States)

    Terada, Masaki; Nakamura, Hideo

    2003-03-01

    Since the mid-1980s, Toyota Motor Corporation has applied CO2 lasers and YAG lasers to machine (welding, piercing, cutting, surface modifying etc.) automobile parts. In recent years diode lasers, which are excellent in terms of cost performance, are now available on the market as a new type of oscillator and are expected to bring about a new age in laser technology. Two current problems with these lasers, however, are the lack of sufficient output and the difficulty in improving the focusing the beam, which is why it has not been easy to apply them to the machining of metal parts in the past. On the other hand, plastics can be joined with low energy because they have a lower melting point than metal and the rate of absorption of the laser is easy to control. Moreover, because the high degree of freedom in molding plastic parts results in many complex shapes that need to be welded, Toyota is looking into the use of diode lasers to weld plastic parts. This article will introduce the problems of plastics welding and the methods to solve them referring to actual examples.

  18. Lean management-the journey from toyota to healthcare.

    Science.gov (United States)

    Teich, Sorin T; Faddoul, Fady F

    2013-04-01

    The evolution of production systems is tightly linked to the story of Toyota Motor Company (TMC) that has its roots around 1918. The term "lean" was coined in 1990 following the exploration of the Toyota model that led to the "transference" thesis sustaining the concept that manufacturing problems and technologies are universal problems faced by management and that these concepts can be emulated in non-Japanese enterprises. Lean is a multi-faceted concept and requires organizations to exert effort along several dimensions simultaneously; some consider a successful implementation either achieving major strategic components of lean, implementing practices to support operational aspects, or providing evidence that the improvements are sustainable in the long term. The article explores challenges and opportunities faced by organizations that intend incorporating lean management principles and presents the specific context of the healthcare industry. Finally, the concepts of "essential few" and customer value are illustrated through a simple example of process change following lean principles, which was implemented in a dental school in the United States.

  19. ANALISIS SISTEM INFORMASI AKUNTANSI PENJUALAN PADA PT HADJI KALLA (TOYOTA CABANG PINRANG

    Directory of Open Access Journals (Sweden)

    Andi Mujahidah

    2017-05-01

    Full Text Available Andi Mujahidah, (2015 "Accounting Information System Analysis Sales At PT Hadji Kalla (Toyota Branch Pinrang" under the guidance of Mrs. Faridah, SE., M.Si, .AK, .ca as first counselor and Mr. Thanwain, SE ,. M.Si as supervisor II. Accounting Information Systems are very important in the sales function remembers every sales transaction must involve the responsibility of a few people within the company. To improve the handling of the sale of the company it needed an adequate internal control sales in its implementation. Problems in this study as follows: (1 How the application of accounting information system of sales at PT Hadji Kalla (Toyota Branch Pinrang? (2 How can the application of the system of credit sales at PT Hadji Kalla (Toyota Branch Pinrang? The research objective is to determine: (1 The application of accounting information system of sales at PT Hadji Kalla (Toyota Branch Pinrang. (2 Analysis of credit sales at PT Hadji Kalla (Toyota Branch Pinrang. The method used is the comparative method and data collection through interviews. After the author doing research and comparing the elements of sale accounting information system applied by PT Hadji Kalla (Toyota Branch Pinrang with elements of information systems sales accounting standard, the writer can say that the PT Hadji Kalla (Toyota Branch Pinrang has implemented a system sales accounting information as appropriate, in order to increase sales, it will have an impact on the company's assets will increase sales and accounting data accuracy and reliability is assured.

  20. Toyota production system - one example to shipbuilding industry

    Directory of Open Access Journals (Sweden)

    Delmo Alves de Moura

    2017-09-01

    Full Text Available The shipbuilding system can use the techniques used in the Toyota Production System as an example for its production process. Production should be lean, minimize defects, stop production and reduce or eliminate inventories. Lean production is regarded by many as simply an enhancement of mass production methods, whereas agility implies breaking out of the mass production mould and producing much more highly customized products - where the customer wants them in any quantity. In a product line context, it amounts to striving for economies of scope, rather than economies of scale ideally serving ever smaller niche markets, even quantities of one, without the high cost traditionally associated with customization. A lean company may be thought of as a very productive and cost efficient producer of goods or services.

  1. Molecular Investigation on the Presence of Hepatitis E Virus (HEV) in Wild Game in North-Western Italy.

    Science.gov (United States)

    Serracca, Laura; Battistini, Roberta; Rossini, Irene; Mignone, Walter; Peletto, Simone; Boin, Claudia; Pistone, Giancarlo; Ercolini, Riccardo; Ercolini, Carlo

    2015-09-01

    Meat products from HEV-infected reservoir animal species are capable of transmitting HEV to humans and represent a public health concern. Human HEV cases have been linked to the consumption of raw or undercooked pig liver sausages, pork, and game meats, such as wild boars and deer worldwide. Direct exposure to swine or wild game species might also represent a source of HEV transmission especially for veterinarians, hunters, or butchers. A limited amount of data is available on HEV prevalence in wild boars in Italy and no data are available for other wild game species intended for human consumption. In this study, the circulation of HEV in four different animal species hunted in north-western Italy was evaluated to gain insight into the infection levels and the genetic diversity of the virus in such animal populations. Liver samples of 372 wild boars, 30 roe deer, 47 European hares and 38 coypus were analyzed for HEV RNA by real-time RT-PCR; positive samples were then sequenced and submitted to phylogenetic analysis. HEV RNA was detected in the livers of 7/372 (1.9%) wild boars tested, while no sample was positive for roe deer, European hare, and coypu. Phylogenetic analysis showed that wild boar HEV sequences belonged to HEV subtypes 3e, 3c, and 3f. Our results indicate that HEV is circulating only in wild boar among the considered game species in north-western Italy and suggest a potential zoonotic risk related to handling and/or consumption of raw or undercooked meat and products made of the liver from this species.

  2. The effectiveness of automatic belts in reducing fatality rates in Toyota Cressidas.

    Science.gov (United States)

    Nash, C E

    1989-12-01

    Toyota Cressidas have had motor driven automatic belts since 1981. Their observed use rates have been consistently close to 100%. This paper compares fatality rates in Toyota Cressidas with those in the similar Nissan Maximas (which are equipped with three-point manual belts) using the latest data from the Fatal Accident Reporting System. After making adjustments for differences in the average ages of front seat occupants of the two fleets, the Toyotas have a fatality rate that is about three-quarters that of the Nissans. From this, the fatality-reducing effectiveness for the Toyota automatic belts is estimated to be 40% with an uncertainty of +/- 8%. This effectiveness estimate is consistent with earlier estimates of automatic belt effectiveness.

  3. THE EFFECT OF TRUST AND BRAND IMAGE ON PURCHASE DECISION (TOYOTA CAR SURVEY IN JAKARTA REGION

    Directory of Open Access Journals (Sweden)

    Setyo Ferry Wibowo

    2017-09-01

    Full Text Available The purpose of this research is to know: 1 influence of confidence to Toyota Agya car purchase decision in Jakarta area, and 2 influence of brand image to Toyota Agya car purchase decision in Jakarta area. The object of this research is 200 respondents of Toyota Agya car users in Jakarta area. Methods of data collection using survey method. Data analysis using SPSS 22. Descriptive test results explain that there is still a lack of trust and brand image in Toyota Agya car in the Jakarta area causing the lack of consumer response to make purchasing decisions. The result of hypothesis testing shows: 1 existence of positive and significant influence of trust toward purchasing decision, 2 existence of positive and significant influence from brand image to purchasing decision.

  4. Hepatitis E virus genotype three infection of human liver chimeric mice as a model for chronic HEV infection

    NARCIS (Netherlands)

    M.D.B. van de Garde (Martijn D.B.); S.D. Pas (Suzan); G. van der Net (Guido); R.A. de Man (Robert); A.D.M.E. Osterhaus (Albert); B.L. Haagmans (Bart); A. Boonstra (Andre); T. Vanwolleghem (Thomas)

    2016-01-01

    textabstractGenotype (gt) 3 hepatitis E virus (HEV) infections are emerging in Western countries. Immunosuppressed patients are at risk of chronic HEV infection and progressive liver damage, but no adequate model system currently mimics this disease course. Here we explore the possibilities of in

  5. Empowering Kanban through TPS-Principles - An Empirical Analysis of the Toyota Production System

    OpenAIRE

    Thun , Jörn-Henrik; Drüke , Martin; Grübner , Andre

    2010-01-01

    Abstract The purpose of this paper is the empirical investigation of the Toyota Production System in order to test existing relationships as they are proposed in theory. The underlying model consists of seven factors reflecting the key practices of the Toyota Production System. Using data from 188 manufacturing plants participating in the High Performance Manufacturing research project, the model?s measurement characteristics were validated through confirmatory factor analysis. Pat...

  6. Peranan Komunikasi Pemasaran Mobil Toyota Dump Truck Dyna Pada Masyarakat Kota Manado

    OpenAIRE

    Roring, Benny; Mewengkang, Norma; Harilama, Stefi

    2015-01-01

    The role of marketing communications cars toyota dyna dump truck in Manado city community. Background: The Community of Indonesian automotive world has witnessed many different brands and types of new cars milling about on the highway though the brand and type of the car recently launched by the automotive world produsennya.perkembangan archipelago is the influx of cars with the latest technology and some of them even offer technology Toyota concept depan.Kehadiran period of 40 years in Indon...

  7. Analisis Pengukuran Waktu Kerja Karyawan Bengkel Toyota Auto 2000 di Balikpapan

    OpenAIRE

    -, Agus -

    2014-01-01

    This study aims to determine the specific labor standard time engine oil replacement vehicle machine Toyota Auto 2000 MT. Balikpapan Haryono used standard working time. Based on interviews with employees of Auto 2000 Toyota workshop. MT. Haryono completed replacement of engine oil required an average completion time of 1 hour of receipt to the consumer.The problem of this study is the labor time required to complete the work car oil changes are in accordance with the standart time in the wor...

  8. Pengaruh Promosi, Desain Produk Dan Kesadaran Merek Terhadap Keputusan Konsumen Untuk Membeli Mobil Toyota Yaris

    OpenAIRE

    Widaningsih, Raden Ayu; Waluyo, Handoyo Djoko; Listyorini, Sari

    2014-01-01

    The purpose of this study is to determine how much influence promotion, product design and brand awareness to the consumer's decision to buy a Toyota Yaris in Nasmoco Pemuda Semarang. The sample is the consumer brand of car owners and users who purchased the Toyota Yaris in PT. Nasmoco Pemuda Semarang. A total of 85 respondents using purposive sampling technique. From the results of the study partially through t-test showed that there is a positive and significant effect between the variables...

  9. The Effect of Differentiation and Promotion Toyota Avanza Purchasing Decision in PT. Nasmoco Pemuda Semarang

    OpenAIRE

    Purnomo, Adityan Dwi; Hadi, Sudharto Prawata; Prabawani, Bulan

    2015-01-01

    PT. Nasmoco Pemuda Semarang is a company engaged in the marketing of Toyota products for Central Java and Yogyakarta. The tied competition of automotive business led to decreased supposed to be adjective in the number of buyers and many new products from Toyota competitors sells new products with a more elegant design and reasonable price. This study is aimed to identify the driving factors of purchase decisions, specifically differentiation (X1) and promotion (X2) factor on purchasing decisi...

  10. The Impact of Marketing Mix (4p's) on Customer Loyalty Towards Toyota Avanza

    OpenAIRE

    Harsono, Rendy

    2016-01-01

    With the tight competition in the automotive industry, customer loyalty has become the key for success. However, customer loyalty is not always easy to earn. With this in mind, the research is established with the goal to analyze the impact of 4P's of Marketing Mix towards customer loyalty on Toyota Avanza.Using questionnaires as data gathering instrument with simple random sampling, 124 respondents were gathered from people around Surabaya, who has bought and ride Toyota Avanza. The data obt...

  11. Energetic macroscopic representation and inversion-based control of a CVT-based HEV

    NARCIS (Netherlands)

    Chouhou, M.; Grée, F.; Jivan, C.; Bouscayrol, A.; Hofman, T.

    2014-01-01

    A Continuous Variable Transmission (CVT) is introduced in the simulation model of a Hybrid Electric Vehicle (HEV). The CVT-based vehicle simulation and its control are deduced from the Energetic Macroscopic Representation (EMR). Simulations are provided to show the interest of the CVT in term of

  12. Energetic macroscopic representation and inversion- based control of a CVT-based HEV

    NARCIS (Netherlands)

    Chouhou, M.; Grée, F.; Jivan, C.; Bouscayrol, A.; Hofman, T.

    2013-01-01

    A Continuous Variable Transmission (CVT) is introduced in the simulation model of a Hybrid Electric Vehicle (HEV). The CVT-based vehicle simulation and its control are deduced from the Energetic Macroscopic Representation (EMR). Simulations are provided to show the interest of the CVT in term of

  13. Modeling and Control of Flexible HEV Charging Station upgraded with Flywheel Energy Storage

    DEFF Research Database (Denmark)

    Dragicevic, Tomislav; Shafiee, Qobad; Wu, Dan

    2014-01-01

    This paper deals with the design of a fast DC charging station (FCS) for hybrid electric vehicles (HEVs) that is connected at a remote location. Power rating of this new technology can go up to a hundred kW and it represents a main challenge for its broad acceptance in distribution systems...

  14. Simulation and Comparison of HEV Battery Control for Best Fuel Economy and Longer Battery Life

    OpenAIRE

    Adel, Boukehili; Youtong, Zhang; shuai, Sun

    2010-01-01

    Almost all HEV battery control strategies keep the battery state of charge (SOC) within a lower limit (SOCmin) (these strategies also called charge sustaining strategies). The goal from sustaining the SOC in this way is to prolong the battery life. But the question is

  15. Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex protein

    NARCIS (Netherlands)

    Beezhold, Donald H.; Hickey, Vicky L.; Kostyal, David A.; Puhl, Henry; Zuidmeer, Laurian; van Ree, Ronald; Sussman, Gordon L.

    2003-01-01

    BACKGROUND: Latex-allergic individuals experience clinical cross-reactivity to a large number of fruits and vegetables. Much of the cross-reactivity can be attributed to Hev b 6, but evidence indicates that additional cross-reactive allergens may be present. A common pan-allergen, which has not

  16. Gümnaasiumiõpilased õpetajate tööst HEV lastega / Ants Reinmaa

    Index Scriptorium Estoniae

    Reinmaa, Ants

    2001-01-01

    Lühikokkuvõte rakendusuuringust, millega selgitati põhi- ja keskkoolide ning gümnaasiumide õpilaste arvamusi ja hoiakuid õpetajate ja õpetajatöö suhtes. Uurimuse ühe osa moodustas keskendumine probleemidele, millistena paistavad gümnaasiumiõpilastele õpetajate tegevus HEV lastega

  17. Prevalence of Hepatitis A virus (HAV) and Hepatitis E virus (HEV) in the patients presenting with acute viral hepatitis.

    Science.gov (United States)

    Joon, A; Rao, P; Shenoy, S M; Baliga, S

    2015-02-01

    Hepatitis A virus (HAV) and Hepatitis E virus (HEV) are both enterically transmitted, resulting in acute viral hepatitis (AVH) in developing countries. They pose major health problems in our country. This study was done to determine prevalence of HAV and HEV in patients presenting with AVH and the co-infection of HAV and HEV in these patients. A cross-sectional study of 2-years duration was conducted in the Department of Microbiology, KMC, Mangalore. A non-random sampling of 958 patients presenting with AVH was considered in the study. On the basis of history, serum samples were analysed for IgM anti-HAV and IgM anti-HEV for the detection of HAV and HEV, respectively using commercially available ELISA kits. Data collected was analysed by using Statistical Package for the Social Sciences (SPSS) version 11.5. The seroprevalence of HAV- and HEV-positive patients were 19.31% and 10.54%, respectively. The seroprevalence of both HAV and HEV in patients with acute viral hepatitis was 11.5%. The prevalence of HAV and HEV among males (68% and 31%) was higher than in females (31% and 20%) and was predominantly seen among young adults. These infections were predominantly seen during end of monsoons and beginning of winter. Though the prevalence of HAV is much higher than that of HEV, co-infection rate of 11.5% mandates the screening for HEV which will be of immense importance in pregnant women and improving levels of personal hygiene among higher socio-economic population. These data will be essential for planning of future vaccination strategies and for better sanitation programme in this part of the country.

  18. ANALISIS PENERAPAN STRATEGI PEMASARAN DALAM PENINGKATAN PANGSA PASAR PADA PT. HADJI KALLA (TOYOTA) CABANG URIP DI MAKASSAR

    OpenAIRE

    MAULADI RAHMAN, EKI

    2012-01-01

    - EKI MAULADI RAHMAN, A211 076 644. Analisis Penerapan Strategi Pemasaran Dalam Peningkatan Pangsa Pasar Pada PT. Hadji Kalla (Toyota) Cabang Urip di Makassar. (dibimbing oleh Muhammad Ismail dan Mukhtar) Tujuan dari penelitian ini adalah untuk mengetahui penerapan strategi pemasaran mobil Toyota pada PT. Hadji Kalla (Toyota) Cabang Urip di Makassar melalui penerapan (produk, harga, promosi dan saluran distribusi) dalam peningkatan pangsa pasar, untuk menganlisis sejauh mana penerapan ...

  19. Swine and rabbits are the main reservoirs of hepatitis E virus in China: detection of HEV RNA in feces of farmed and wild animals.

    Science.gov (United States)

    Xia, Junke; Zeng, Hang; Liu, Lin; Zhang, Yulin; Liu, Peng; Geng, Jiabao; Wang, Lin; Wang, Ling; Zhuang, Hui

    2015-11-01

    Hepatitis E virus (HEV) infection is recognized as a zoonosis. The prevalence of HEV RNA and anti-HEV antibodies in many animal species has been reported, but the host range of HEV is unclear. The aims of this study were to investigate HEV infection in various animal species and to determine the reservoirs of HEV. Eight hundred twenty-two fecal samples from 17 mammal species and 67 fecal samples from 24 avian species were collected in China and tested for HEV RNA by RT-nPCR. The products of PCR were sequenced and analyzed phylogenetically. The positive rates of HEV RNA isolated from pigs in Beijing, Shandong, and Henan were 33%, 30%, and 92%, respectively, and that from rabbits in Beijing was 5%. HEV RNA was not detectable in farmed foxes, sheep or sika deer, or in wild animals in zoos, including wild boars, yaks, camels, Asiatic black bears, African lions, red pandas, civets, wolves, jackals and primates. Sequence analysis revealed that swine isolates had 97.8%-98.4% nucleotide sequence identity to genotype 4d isolates from patients in Shandong and Jiangsu of China. Phylogenetic analysis showed that swine HEV isolates belong to genotype 4, including subgenotype 4h in Henan and 4d in Beijing and Shandong. The rabbit HEV strains shared 93%-99% nucleotide sequence identity with rabbit strains isolated from Inner Mongolia. In conclusion, swine and rabbits have been confirmed to be the main reservoirs of HEV in China.

  20. Preliminary study on the detection of hepatitis E virus (HEV antibodies in pigs and wild boars in Poland

    Directory of Open Access Journals (Sweden)

    Weiner Marcin

    2016-12-01

    Full Text Available Introduction: Although HEV infection in pigs does not pose a major economic risk to pork production, the risk of zoonotic transmission to humans is an important aspect of public health. HEV genotype 3 infections were reported in developed countries in individuals who had consumed raw meat or meat products from deer, wild boars, or pigs. The aim of the study was the analysis of the occurrence of HEV-specific antibodies among wild boars and domestic pigs in Poland. Material and Methods: A total of 290 samples from wild boars and 143 samples from pigs were tested. The antibodies were tested by ELISA. Results: The presence of anti-HEV IgG was demonstrated in 44.1% of pigs and 31.0% of wild boars. Anti-HEV IgG antibodies were detected in 1.4% of samples from pigs and in 2.1% of samples from wild boars at borderline level. The statistical analysis shows significant differences in the positive results for anti-HEV IgG between the groups of pigs and wild boars (P = 0.0263. Conclusion: Regular surveillance of the occurrence of HEV in swine and wild boars should be performed in the future.

  1. The newly developed Toyota plug-in hybrid system

    Energy Technology Data Exchange (ETDEWEB)

    Takaoka, Toshifumi; Ichinose, Hiroki [Toyota Motor Corporation (Japan)

    2010-07-01

    Toyota has been introducing several hybrid vehicles (HV) as a countermeasure to the automobile's concerns, like CO2 reduction, energy security, and emission reduction in urban areas. A next step towards an even more effective solution for these concerns is a plug-in hybrid vehicle (PHV). This vehicle combines the advantages of electric vehicles (EV), which use clean electric energy, and HV, with it's high environmental potential and user- friendliness comparable to conventional vehicles, such as a long cruising range. This paper describes a newly developed plug-in hybrid system and its vehicle performance. This system uses a Li-ion battery with high energy density and has an affordable EV range without sacrificing cabin space. The vehicle achieves a CO2 emission of 59g/km and meets the most stringent emission regulations in the world. The new PHV is a forerunner of the large-scale mass production PHV two years later. PHVs have the potential to become popular as a realistic solution towards sustainable mobility by renewable electricity usage in the future. (orig.)

  2. Toyota production system quality improvement initiative improves perioperative antibiotic therapy.

    Science.gov (United States)

    Burkitt, Kelly H; Mor, Maria K; Jain, Rajiv; Kruszewski, Matthew S; McCray, Ellesha E; Moreland, Michael E; Muder, Robert R; Obrosky, David Scott; Sevick, Mary Ann; Wilson, Mark A; Fine, Michael J

    2009-09-01

    To assess the role of a Toyota production system (TPS) quality improvement (QI) intervention on appropriateness of perioperative antibiotic therapy and in length of hospital stay (LOS) among surgical patients. Pre-post quasi-experimental study using local and national retrospective cohorts. We used TPS methods to implement a multifaceted intervention to reduce nosocomial methicillin-resistant Staphylococcus aureus infections on a Veterans Affairs surgical unit, which led to a QI intervention targeting appropriate perioperative antibiotic prophylaxis. Appropriate perioperative antibiotic therapy was defined as selection of the recommended antibiotic agents for a duration not exceeding 24 hours from the time of the operation. The local computerized medical record system was used to identify patients undergoing the 25 most common surgical procedures and to examine changes in appropriate antibiotic therapy and LOS over time. Overall, 2550 surgical admissions were identified from the local computerized medical records. The proportion of surgical admissions receiving appropriate perioperative antibiotics was significantly higher (P <.01) in 2004 after initiation of the TPS intervention (44.0%) compared with the previous 4 years (range, 23.4%-29.8%) primarily because of improvements in compliance with antibiotic therapy duration rather than appropriate antibiotic selection. There was no statistically significant decrease in LOS over time. The use of TPS methods resulted in a QI intervention that was associated with an increase in appropriate perioperative antibiotic therapy among surgical patients, without affecting LOS.

  3. Driving improvement in patient care: lessons from Toyota.

    Science.gov (United States)

    Thompson, Debra N; Wolf, Gail A; Spear, Steven J

    2003-11-01

    Nurses today are attempting to do more with less while grappling with faulty error-prone systems that do not focus on patients at the point of care. This struggle occurs against a backdrop of rising national concern over the incidence of medical errors in healthcare. In an effort to create greater value with scarce resources and fix broken systems that compromise quality care, UPMC Health System is beginning to master and implement the Toyota Production System (TPS)--a method of managing people engaged in work that emphasizes frequent rapid problem solving and work redesign that has become the global archetype for productivity and performance. The authors discuss the rationale for applying TPS to healthcare and implementation of the system through the development of "learning unit" model lines and initial outcomes, such as dramatic reductions in the number of missing medications and thousands of hours and dollars saved as a result of TPS-driven changes. Tracking data further suggest that TPS, with sufficient staff preparation and involvement, has the potential for continuous, lasting, and accelerated improvement in patient care.

  4. Application of the Toyota Production System improves core laboratory operations.

    Science.gov (United States)

    Rutledge, Joe; Xu, Min; Simpson, Joanne

    2010-01-01

    To meet the increased clinical demands of our hospital expansion, improve quality, and reduce costs, our tertiary care, pediatric core laboratory used the Toyota Production System lean processing to reorganize our 24-hour, 7 d/wk core laboratory. A 4-month, consultant-driven process removed waste, led to a physical reset of the space to match the work flow, and developed a work cell for our random access analyzers. In addition, visual controls, single piece flow, standard work, and "5S" were instituted. The new design met our goals as reflected by achieving and maintaining improved turnaround time (TAT; mean for creatinine reduced from 54 to 23 minutes) with increased testing volume (20%), monetary savings (4 full-time equivalents), decreased variability in TAT, and better space utilization (25% gain). The project had the unanticipated consequence of eliminating STAT testing because our in-laboratory TAT for routine testing was less than our prior STAT turnaround goal. The viability of this approach is demonstrated by sustained gains and further PDCA (Plan, Do, Check, Act) improvements during the 4 years after completion of the project.

  5. Pengaruh Kapasitas Kondensator Terhadap Daya Mesin Toyota 5K

    Directory of Open Access Journals (Sweden)

    M. Alfian Mizar

    2009-02-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui perbedaan daya motor dan daya maksimumnya pada mesin Toyota 5K untuk pemakaian kondensator berkapasitas 0,15 mf, 0,22 mf, dan 0,25 mf. Desain yang digunakan adalah eksperimen satu jalur (one-way design dengan 3 kelompok eksperimen. Pengumpulan datanya dilakukan dengan observasi, sedangkan instrumen pengukurannya menggunakan "Prony Brake" dengan cara mengukur putaran mesin dan momen torsi yang terjadi. Hasil analisis varian menunjukkan adanya perbedaan yang dignifikan, sedangkan Scheffe test memberikan hasil: (1 ada perbedaan daya motor antara pemasangan kondensator berkapasitas 0,15 mf dengan 0,22 mf, (2 ada perbedaan daya motor antara pemasangan kondensator berkapasitas 0,15 mf dengan 0,25 mf, (3 tidak ada perbedaan daya motor antara pemasangan kondensator berkapasitas 0,22 mf dengan 0,25 mf. Daya maksimum yang dihasilkan pada pemasangan kondensator yang berkapasitas 0,15 mf, 0,22 mf, dan 0,25 mf nasing-masing adalah 59,46153+1,46177 PK, 60,32692+1,35744 PK, dan 60,78461+1,68140 PK. Jenis kondensator yang dapat menghasilkan daya paling maksimum adalah kondensator berkapasitas 0,25 mf.

  6. Lean implementation strategies: how are the Toyota way principles addressed?

    Directory of Open Access Journals (Sweden)

    Coetzee, Rojanette

    2016-11-01

    Full Text Available Lean manufacturing is widely considered to be a proven organisational improvement philosophy, yet the success rate of lean implementation in industry remains relatively low. Neglect of the human aspect of lean manufacturing is often cited as the leading reason for this, despite the emphasis so clearly placed upon this aspect by the creators of the lean philosophy. This article reviews the extent to which the human dimensions of the lean philosophy, as described in the Toyota Way management principles, have been incorporated in lean implementation strategies. It is found that few of the principles feature prominently in these strategies. Notably absent are those linked to the ‘respect for people’ pillar , which forms half of the T oyota Way’s foundation. This conclusion indicates that the adoption of the lean philosophy runs contrary to the oft-repeated message from its creators that no tenet of the philosophy should be favoured at the expense of another. This may provide valuable insight into the reasons for the high implementation failure rate.

  7. Determination of the full-genome sequence of hepatitis E virus (HEV) SAAS-FX17 and use as a reference to identify putative HEV genotype 4 virulence determinants.

    Science.gov (United States)

    Zhu, Yumin; Yu, Xiaoming; Huang, Fenfen; Yu, Ruisong; Dong, Shijuan; Si, Fusheng; Zhang, Yuanshu; Li, Zhen

    2012-11-08

    Four major genotypes of hepatitis E virus (HEV), the causative agent of hepatitis E, have so far been recognized. While genotypes 3 and 4 are both zoonotic, the disease symptoms caused by the latter tend to be more severe. To examine if specific nucleotide/amino acid variations between genotypes 3 and 4 play a role in determining the severity of hepatitis E disease, the complete genome of one swine HEV genotype 4 isolate, SAAS-FX17, was determined and compared with other genotype 4 and genotype 3 genomes to identify putative HEV genotype 4 virulence determinants. A total of 42 conformable nt/aa variations between genotype 3 and 4 HEVs were detected, of which 19 were proposed to be potential disease severity determinants for genotype 4 strains. One potential determinant was located in each of the 5'-UTR and 3'-UTR, 3 and 12 within ORF1 and ORF2 respectively, and 2 in the junction region.

  8. How much of Toyota's philosophy is embedded in health care at the organisational level? A review.

    Science.gov (United States)

    Antierens, Alain; Beeckman, Dimitri; Verhaeghe, Sofie; Myny, Dries; Van Hecke, Ann

    2018-05-01

    Identify which of Toyota's principles are reported in health care institutions at the organisational level and to identify the type of reported outcomes related to the effectiveness of lean production reported in these studies. No scientific research has been conducted to determine which of Toyota's principles are embedded in health care systems. This knowledge is needed to perform targeted adjustments in health care. Sixty studies were identified for the final analysis. Some Toyota Way principles appear more deeply embedded in health care institutions than others are. Not all principles of Toyota's philosophy and production system were embedded in the studies in this review. The type of reported outcomes at the organisational level was diverse. This literature review increases our knowledge about how many (and which) of the Toyota Way principles are embedded in health care. This knowledge may support reflection by nursing managers about how the full range of lean management principles could be embedded at the managerial and/or operational level. © 2018 John Wiley & Sons Ltd.

  9. Total Quality Management and Business Excellence: The Best Practices at Toyota Motor Corporation.

    Directory of Open Access Journals (Sweden)

    Sorin-George Toma

    2017-05-01

    Full Text Available Today’s rough competition at a global level in all spheres of activity imposes companies worldwide to make sustained efforts in order to improve their products, services and processes. The automotive industry has always provided valuable examples of companies that achieved business excellence by putting quality at the core of their production system such as Toyota Motor Corporation. It has continuously designed, implemented and developed the Toyota Production System that influenced the emergence of the business excellence models. The paper aims to highlight the relationship between the concepts of total quality management and business excellence, and to identify and analyze the best practices related to them at Toyota Motor Corporation, a leader of automotive industry. The information obtained through the direct and personal observation method and from multiple secondary sources of data was collected, processed and analyzed in order to achieve the objectives of the paper. The main results show that the best practices of Toyota Motor Corporation related to total quality management and business excellence derive from the Toyota Production System and these practices are to be found in the attributes of business excellence.

  10. Toyota beamline (BL33XU) at SPring-8

    Energy Technology Data Exchange (ETDEWEB)

    Nonaka, T., E-mail: nonaka@mosk.tytlabs.co.jp; Dohmae, K.; Hayashi, Y.; Yamaguchi, S.; Nagai, Y.; Hirose, Y. [Toyota Central R& D Labs., Inc., 41-1 Nagakute Aichi 480-1192 Japan (Japan); Araki, T. [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE UK (United Kingdom); Tanaka, T.; Kitamura, H. [RIKEN Harima Institute 1-1-1 Koto Sayo, Hyogo 679-5148 (Japan); Uruga, T.; Yamazaki, H.; Yumoto, H.; Ohashi, H.; Goto, S. [JASRI/SPring-8 1-1-1 Koto Sayo, Hyogo 679-5148 (Japan)

    2016-07-27

    The Toyota beamline (BL33XU) at SPring-8 is an undulator beamline developed to assist in the study of various automotive-related materials. The light source is a tapered in-vacuum undulator that provides a variable energy band width as well as a high brilliance X-ray beam. Two different optical arrangements are available: Optics 1 and Optics 2. Optics 1 is dedicated to time-resolved X-ray absorption spectroscopy (XAFS), and consists of two channel-cut crystal monochromators and four water-cooled flat Si mirrors. The Si(111) and Si(220) monochromator crystals cover an energy range of 4.0–46.0 keV and are driven by high-speed AC servo motors. These monochromators, in conjunction with the tapered undulator, enable high-quality XAFS data acquisition with a temporal resolution of 10 ms. Optics 2 is optimized for X-ray diffraction, scattering and imaging and includes a recently installed double crystal monochromator, two water-cooled flat Si mirrors and Kirkpatrick-Baez (KB) focusing mirrors. The monochromator incorporates parallel mounted Si(111) and Si(311) crystals and covers an energy range of 4.5–70 keV. The beamline provides two experimental stations: Exp. Hutch 2 and Exp. Hutch 3. The gas supply system and mass spectrometers installed in Exp. Hutch 2 allow in-operando measurements under various atmospheres. The scanning three-dimensional X-ray diffraction (scanning 3DXRD) microscopy instrumentation developed and installed in Exp. Hutch 3 enables non-destructive orientation and stress mapping of 1 mm-thick steel specimens using a high energy microbeam.

  11. Toyota beamline (BL33XU) at SPring-8

    International Nuclear Information System (INIS)

    Nonaka, T.; Dohmae, K.; Hayashi, Y.; Yamaguchi, S.; Nagai, Y.; Hirose, Y.; Araki, T.; Tanaka, T.; Kitamura, H.; Uruga, T.; Yamazaki, H.; Yumoto, H.; Ohashi, H.; Goto, S.

    2016-01-01

    The Toyota beamline (BL33XU) at SPring-8 is an undulator beamline developed to assist in the study of various automotive-related materials. The light source is a tapered in-vacuum undulator that provides a variable energy band width as well as a high brilliance X-ray beam. Two different optical arrangements are available: Optics 1 and Optics 2. Optics 1 is dedicated to time-resolved X-ray absorption spectroscopy (XAFS), and consists of two channel-cut crystal monochromators and four water-cooled flat Si mirrors. The Si(111) and Si(220) monochromator crystals cover an energy range of 4.0–46.0 keV and are driven by high-speed AC servo motors. These monochromators, in conjunction with the tapered undulator, enable high-quality XAFS data acquisition with a temporal resolution of 10 ms. Optics 2 is optimized for X-ray diffraction, scattering and imaging and includes a recently installed double crystal monochromator, two water-cooled flat Si mirrors and Kirkpatrick-Baez (KB) focusing mirrors. The monochromator incorporates parallel mounted Si(111) and Si(311) crystals and covers an energy range of 4.5–70 keV. The beamline provides two experimental stations: Exp. Hutch 2 and Exp. Hutch 3. The gas supply system and mass spectrometers installed in Exp. Hutch 2 allow in-operando measurements under various atmospheres. The scanning three-dimensional X-ray diffraction (scanning 3DXRD) microscopy instrumentation developed and installed in Exp. Hutch 3 enables non-destructive orientation and stress mapping of 1 mm-thick steel specimens using a high energy microbeam.

  12. Co-opetition and knowledge co-creation in Japanese supplier-networks : The case of Toyota

    NARCIS (Netherlands)

    Wilhelm, Miriam M.; Kohlbacher, Florian

    This article examines how knowledge co-creation takes place within the Toyota network. We extend the work of Dyer and Nobeoka, who contributed to the theory of network-level learning by showing how Toyota succeeded in 'creating and managing a high-performance knowledge-sharing network'. By examining

  13. Pengaruh Fungsi Advence Centrifugal dan Putaran Terhadap Konsumsi Bahan Bakar pada Motor Toyota Tipe 4K

    Directory of Open Access Journals (Sweden)

    Paryono Paryono

    2009-02-01

    Full Text Available Kesalahan yang sering dilakukan oleh pengelola bengkel mobil dan mekaniknya adalah pada waktu melaksanakan pekerjaan tune up. Mereka hanya menyetel saat pengapian dan platina saja tanpa mengontrol fungsi advance centrifugal. Penelitian ini bertujuan untuk mengetahui perbedaan konsumsi bahan-bakar pada motor bensin saat advance centrifugal bekerja normal dan macet pada putaran menengah dan tinggi. Sebagai obyek penelitian digunakan motor Toyota Type 4K yang telah diservis sesuai dengan standar industri. Hasil pengujian menunjukkan bahwa putaran motor dan kondisi advance centrifugal ada interaksi yang signifikan dengan F rasio = 82,975 dan P lebih kecil 0,05 terhadap konsumsi bensin pada motor Toyota Type 4K. Hal ini berarti bahwa pada berbagai putaran motor dengan kondisi advance centrifugal bekerja normal, konsumsi bensin pada motor Toyota Type 4K lebih irit jika dibandingkan dengan kondisi advance centrifugal yang macet.

  14. Il Toyota way e la crisi. Tornare alle origini del lean management per sopravvivere e prosperare

    OpenAIRE

    A. Camuffo; D. Weber

    2009-01-01

    Nel settore automobilistico gli occhi sono tutti puntati sui bailouts delle Big Three americane e sugli interventi statali a supporto dei produttori europei, oltre che sulla scommessa rappresentata dall’operazione FIAT-Chrysler. Ma la domanda più importante per capire dove andrà il settore auto è cosa accadrà a Toyota. È questa la vera domanda che ci si deve porre, perché il Toyota Way è importante, al di là del suo destino individuale, per il destino del settore automobi...

  15. Design Of Toyota Home Service Applications For AUTO2000 Based On Android

    OpenAIRE

    Aswin, Arief Rahmadian

    2016-01-01

    AUTO2000 is a network of sales services, maintenance, repair and supply of spare parts Toyota that was established in 1975 under the name Astra Motor Sales, in 1989 changed its name to AUTO2000 with management that has been handled entirely by PT. Astra International Tbk. Services provided by AUTO2000 one of which is a service of Toyota Home Service, a service provided by the service vehicle Auto 2000 where customers can service their vehicles without having to come to the dealership Auto 200...

  16. Using Seaports in Distribution Logistics of Cars on the Example of the Toyota Company

    Directory of Open Access Journals (Sweden)

    Zbigniew Lukasik

    2015-12-01

    Full Text Available The maritime transport is an element of the intermodal transport, which makes the distribution process of automotive industry more efficient. The article presents possibilities of using the sea transport and seaports in the logistic chain of car distribution on the example of the Toyota company. Toyota is one of the largest car manufacturers in the world, having (among others its logistic centers of distribution in seaports of Grimsby (Grimsby Logistic Centre in North East Lincolnshire – England and Sagunto (Sagunto Logistic Centre in Valencia – Spain.

  17. ANALISIS SISTEM INFORMASI AKUNTANSI PENJUALAN PADA PT HADJI KALLA (TOYOTA CABANG PINRANG

    Directory of Open Access Journals (Sweden)

    ANDI MUJAHIDAH

    2017-06-01

    The method used is the comparative method and data collection through interviews. After the author doing research and comparing the elements of sale accounting information system applied by PT Hadji Kalla (Toyota Branch Pinrang with elements of information systems sales accounting standard, the writer can say that the PT Hadji Kalla (Toyota Branch Pinrang has implemented a system sales accounting information as appropriate, in order to increase sales, it will have an impact on the company's assets will increase sales and accounting data accuracy and reliability is assured.

  18. Plan estratégico para Toyota USA 2011-2013

    OpenAIRE

    Arrieta Clavijo, María Luisa Jesús; Cabero Rojas, Augusto Mauricio; Quinto Tapia, Daniel Federico

    2015-01-01

    Plan Estratégico para Toyota USA 2011-2013 permitirá, a través del uso de herramientas propias del análisis externo e interno, identificar sus ventajas competitivas, su posición competitiva y establecer los planes funcionales en tres ámbitos principales: marketing, operaciones y recursos humanos. Estos planes funcionales se enfocarán en las acciones estratégicas que permitan a Toyota generar una mayor eficiencia operativa, redireccionarse a su consumidor y aplicar una estrategia de marketin...

  19. Optimizing value utilizing Toyota Kata methodology in a multidisciplinary clinic.

    Science.gov (United States)

    Merguerian, Paul A; Grady, Richard; Waldhausen, John; Libby, Arlene; Murphy, Whitney; Melzer, Lilah; Avansino, Jeffrey

    2015-08-01

    Value in healthcare is measured in terms of patient outcomes achieved per dollar expended. Outcomes and cost must be measured at the patient level to optimize value. Multidisciplinary clinics have been shown to be effective in providing coordinated and comprehensive care with improved outcomes, yet tend to have higher cost than typical clinics. We sought to lower individual patient cost and optimize value in a pediatric multidisciplinary reconstructive pelvic medicine (RPM) clinic. The RPM clinic is a multidisciplinary clinic that takes care of patients with anomalies of the pelvic organs. The specialties involved include Urology, General Surgery, Gynecology, and Gastroenterology/Motility. From May 2012 to November 2014 we performed time-driven activity-based costing (TDABC) analysis by measuring provider time for each step in the patient flow. Using observed time and the estimated hourly cost of each of the providers we calculated the final cost at the individual patient level, targeting clinic preparation. We utilized Toyota Kata methodology to enhance operational efficiency in an effort to optimize value. Variables measured included cost, time to perform a task, number of patients seen in clinic, percent value-added time (VAT) to patients (face to face time) and family experience scores (FES). At the beginning of the study period, clinic costs were $619 per patient. We reduced conference time from 6 min/patient to 1 min per patient, physician preparation time from 8 min to 6 min and increased Medical Assistant (MA) preparation time from 9.5 min to 20 min, achieving a cost reduction of 41% to $366 per patient. Continued improvements further reduced the MA preparation time to 14 min and the MD preparation time to 5 min with a further cost reduction to $194 (69%) (Figure). During this study period, we increased the number of appointments per clinic. We demonstrated sustained improvement in FES with regards to the families overall experience with their providers

  20. Use of the Toyota management principles for evaluation of the company’s mission

    Directory of Open Access Journals (Sweden)

    Jacek Selejdak

    2013-04-01

    Full Text Available In the paper there were described the elements of the Toyota roof. Electroacoustic products were characterized. Immaterial resources of the company were analyzed. To do so, the BOST survey, whose questionnaires were filled in by employees of the chosen enterprise, was used. Particular attention was paid to the following factors: quality, costs, lead time, work safety and personnel morale

  1. Learning from Toyota: How Action Learning Can Foster Competitive Advantage in New Product Development (NPD)

    Science.gov (United States)

    Fuchs, Barbara

    2007-01-01

    New product development and commercialization are essential to entrepreneurial growth and international competitiveness. Excellence in this area is strongly supported by individual and organizational learning efforts. By analyzing how Japanese car manufacturer Toyota organizes learning, this paper evaluates the potential of action learning to…

  2. The Toyota product development system applied to a design management workshop model

    DEFF Research Database (Denmark)

    Thyssen, Mikael Hygum; Emmitt, Stephen; Bonke, Sten

    2008-01-01

    reports the early findings of a research project which aims to develop a workshop method for lean design management in construction through a deeper understanding of the Toyota product development system (TPDS) and value theory in general. Results from a case-study will be presented and a theoretical...

  3. Review of Lean Construction Conference Proceedings and Relationship to the Toyota Production System Framework

    Science.gov (United States)

    Jacobs, Gideon Francois

    2010-01-01

    The objective of this study was to align the International Group of Lean Construction (IGLC) conference proceedings against the Toyota Production System (TPS) to determine how well research themes in construction studies align with the TPS framework. Factories around the world that have implemented the TPS framework have experienced impressive…

  4. General Motors ja Toyota otsivad koostöövõimalusi

    Index Scriptorium Estoniae

    2006-01-01

    General Motors ja Toyota teatasid, et on loobunud koostööst hübriidautode arendamisel, uus koostöölepe ettevõtete vahel sõlmitakse sõiduautode turvalisust ja keskkonnasõbralikkust käsitlevate uuringute korraldamiseks

  5. Toyota/Skyline Technical Education Network. Cooperative Demonstration Program. Final Performance Report.

    Science.gov (United States)

    Skyline Coll., San Bruno, CA.

    A joint project was conducted between Toyota Motor Sales and Skyline College (in the San Francisco, California, area) to create an automotive technician training program that would serve the needs of working adults. During the project, a model high technology curriculum suitable for adults was developed, the quality of instruction available for…

  6. The Role of Ambidexterity in Managing Buyer–Supplier Relationships : The Toyota Case

    NARCIS (Netherlands)

    Aoki, Katsuki; Wilhelm, Miriam

    2017-01-01

    Most ambidexterity theories deal with managing exploration–exploitation trade-offs among business units within firms or between alliance partners, but these theories remain yet to be extended to the buyer-supplier relationship level. Through an in-depth case study of the Toyota Motor Corporation, we

  7. 3WCC Temperature Integration in a Gasoline-HEV Optimal Energy Management Strategy

    Directory of Open Access Journals (Sweden)

    Pierre Michel

    2014-02-01

    Full Text Available For a gasoline-hybrid electric vehicle (HEV, the energy management strategy (EMS is the computation of the distribution between electric and gasoline propulsion. Until recently, the EMS objective was to minimize fuel consumption. However, decreasing fuel consumption does not directly minimize the pollutant emissions, and the 3-way catalytic converter (3WCC must be taken into account. This paper proposes to consider the pollutant emissions in the EMS, by minimizing, with the Pontryagin minimum principle, a tradeoff between pollution and fuel consumption. The integration of the 3WCC temperature in the EMS is discussed and finally a simplification is proposed.

  8. cDNA encoding a polypeptide including a hev ein sequence

    Energy Technology Data Exchange (ETDEWEB)

    Raikhel, Natasha V. (Okemos, MI); Broekaert, Willem F. (Dilbeek, BE); Chua, Nam-Hai (Scarsdale, NY); Kush, Anil (New York, NY)

    2000-07-04

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1018 nucleotides long and includes an open reading frame of 204 amino acids. The deduced amino acid sequence contains a putative signal sequence of 17 amino acid residues followed by a 187 amino acid polypeptide. The amino-terminal region (43 amino acids) is identical to hevein and shows homology to several chitin-binding proteins and to the amino-termini of wound-induced genes in potato and poplar. The carboxyl-terminal portion of the polypeptide (144 amino acids) is 74-79% homologous to the carboxyl-terminal region of wound-inducible genes of potato. Wounding, as well as application of the plant hormones abscisic acid and ethylene, resulted in accumulation of hevein transcripts in leaves, stems and latex, but not in roots, as shown by using the cDNA as a probe. A fusion protein was produced in E. coli from the protein of the present invention and maltose binding protein produced by the E. coli.

  9. Assessment by Simu ation of Benefits of New HEV Powertrain Configurations Évaluation par simulation des bénéfices de nouvelles chaînes de traction hybrides

    Directory of Open Access Journals (Sweden)

    Kim N.

    2013-05-01

    Full Text Available During the past couple of years, numerous powertrain configurations for Hybrid Electric Vehicles (HEV have been introduced into the marketplace. The current dominant architecture is the power-split configuration with the input split (single-mode from Toyota and Ford. General Motors (GM recently introduced a two-mode power-split configuration for applications in sport utility vehicles. Also, the first commercially available Plug-In Hybrid Electric Vehicle (PHEV — the GM Volt — was introduced into the market in 2010. The GM Volt uses a series-split powertrain architecture, which provides benefits over the series architecture, which typically has been considered for Electric-Range Extended Vehicles (E-REV. This paper assesses the benefits of these different powertrain architectures (single-mode versus multi-mode for HEV (series versus GM Voltec for PHEV by comparing component sizes, system efficiency and fuel consumption over several drive cycles. On the basis of dynamic models, a detailed component control algorithm was developed for each configuration. The powertrain components were sized to meet all-electric-range, performance and grade-capacity requirements. This paper presents and compares the impact of these different powertrain configurations on component size and fuel consumption. Durant les dernières années, de nombreuses configurations de motorisation pour véhicules hybrides ont été introduites sur le marché. La solution dominante est actuellement la dérivation de puissance en configuration ‘input split’ simple mode utilisée par Toyota et Ford. General Motors (GM a récemment introduit une configuration basée sur la dérivation de puissance avec deux modes pour application sur des SUV (Sport Utility Vehicle. Par ailleurs, le premier véhicule hybride rechargeable la Volt de GM a été introduite sur le marché en 2010. La Volt utilise une architecture qui autorise plusieurs modes : électrique, série et dérivation de

  10. Effectiveness of Toyota process redesign in reducing thyroid gland fine-needle aspiration error.

    Science.gov (United States)

    Raab, Stephen S; Grzybicki, Dana Marie; Sudilovsky, Daniel; Balassanian, Ronald; Janosky, Janine E; Vrbin, Colleen M

    2006-10-01

    Our objective was to determine whether the Toyota Production System process redesign resulted in diagnostic error reduction for patients who underwent cytologic evaluation of thyroid nodules. In this longitudinal, nonconcurrent cohort study, we compared the diagnostic error frequency of a thyroid aspiration service before and after implementation of error reduction initiatives consisting of adoption of a standardized diagnostic terminology scheme and an immediate interpretation service. A total of 2,424 patients underwent aspiration. Following terminology standardization, the false-negative rate decreased from 41.8% to 19.1% (P = .006), the specimen nondiagnostic rate increased from 5.8% to 19.8% (P Toyota process change led to significantly fewer diagnostic errors for patients who underwent thyroid fine-needle aspiration.

  11. The Enigma of Toyota's Competitive Advantage: Is Denso the Missing Link in the Academic Literature?

    OpenAIRE

    Evelyn Anderson

    2003-01-01

    This paper analyses the reasons for the competitiveness of Toyota. It focuses on the company’s unique relationship with one partner supplier – Denso – where contingency loss potential is the greatest. A literature review reveals some gaps between the English and Japanese literature. The author uses resource based view literature, game theory literature, transaction cost literature and the concept of positive external economy to explain Toyota’s success. She also identifies a future research q...

  12. PELANGGARAN PRINSIP-PRINSIP KERJA SAMA PADA IKLAN TOYOTA VERSI DORAEMON-NOBITA BBQ

    Directory of Open Access Journals (Sweden)

    Idrus Idrus

    2017-03-01

    Full Text Available Kepatuhan pada prinsip-prinsip kerja sama Grice dalam berkomunikasi akan menyebabkan komunikasi berjalan efisien. Iklan merupakan salah satu bentuk mengkomunikasikan produk atau jasa. Bahasa Iklan dapat menciptakan efek persuasi yang kuat dengan melakukan pelanggaran terhadap maksim-maksim pada prinsip-prinsip kerja sama Grice. Pada makalah ini dipaparkan prinsip-prinsip kerja sama pada iklan Toyota versi Doraemon-Nobita BBQ dan tujuan pembuat iklan melakukan pelanggaran maksim-maksim tersebut.

  13. PELANGGARAN PRINSIP-PRINSIP KERJA SAMA PADA IKLAN TOYOTA VERSI DORAEMON-NOBITA BBQ

    OpenAIRE

    Idrus Idrus

    2017-01-01

    Kepatuhan pada prinsip-prinsip kerja sama Grice dalam berkomunikasi akan menyebabkan komunikasi berjalan efisien. Iklan merupakan salah satu bentuk mengkomunikasikan produk atau jasa. Bahasa Iklan dapat menciptakan efek persuasi yang kuat dengan melakukan pelanggaran terhadap maksim-maksim pada prinsip-prinsip kerja sama Grice. Pada makalah ini dipaparkan prinsip-prinsip kerja sama pada iklan Toyota versi Doraemon-Nobita BBQ dan tujuan pembuat iklan melakukan pelanggaran maksim-maksim tersebut.

  14. Transportation flow analysis in a centralised supply chain at Toyota Material Handling Europe

    OpenAIRE

    Gustavsson, Styrbjörn; Öberg, Mikael

    2010-01-01

    This report is the result of a Master Thesis written at Toyota Material Handling Europe (TMHE), with the purpose to map the existing spare part supply chain structure and to analyse future suggested supply chain structures with a focus on transportation flows. TMHE is one of the world’s largest producing forklift distributers with large market shares throughout Europe. Besides the main activity of forklifts the aftermarket of distributing spare parts is a major business. With a current decent...

  15. Implications of the Tohoku earthquake for Toyota's coordination mechanism: Supply chain disruption of automotive semiconductors

    OpenAIRE

    Matsuo, Hirofumi

    2015-01-01

    The 2011 Tohoku Earthquake damaged severely and extensively a large geographical area and caused devastating disruptions to the industrial supply chains in Japan. This paper focuses on a case of supply disruption of the automotive microcontroller units, which were produced by Renesas Electronics and supplied to Toyota via its first tier vendors like Denso. The first purpose of this paper is to describe, from a supply chain management view point, what happened and what actions these companies ...

  16. Analisis Perbandingan Sikap Konsumen terhadap Toyota Avanza dan Daihatsu Xenia di Pekanbaru

    OpenAIRE

    Nursanti, Aida; Sulistyowati, Lilis; Wulandari, Sri Ayu

    2014-01-01

    This research aim to to analyse do there is difference of consumer attitude factor in buying brand car of Toyota AVANZA and of Daihatsu XENIA influenced by product, brand, promotion and price.Study sampling accidental the uses This of technique selected 100 samples. Methods data qualitative of method a is study this in used Analysis of analysis, data quantitative of analysis test different of analysis and.From result of examination which have been, There are difference which is consumer attit...

  17. Pengaruh Produk, Harga, Dan Promosi Terhadap Keputusan Pembelian Toyota Yaris Pada PT. Nasmoco Gombel Semarang

    OpenAIRE

    Perwira, Faber Tri; Prihartini, Apriatni Endang; Wijayanto, Andi

    2013-01-01

    The purpose of this study is to investigate and examine the effect of product, price, and promotion to the Toyota Yaris purchasing decisions on PT. Nasmoco Gombel Semarang. This study uses explanatory research approach to the 94 respondents who were taken by purposive sampling method.Techniques of data collection using questionnaires, interviews, and documentation. The data obtained were analyzed using linear regression analysis. Based on the results of analysis variables influence product pu...

  18. ANALISIS SISTEM INFORMASI AKUNTANSI PENJUALAN PADA PT HADJI KALLA (TOYOTA) CABANG PINRANG

    OpenAIRE

    Andi Mujahidah

    2017-01-01

    Andi Mujahidah, (2015) "Accounting Information System Analysis Sales At PT Hadji Kalla (Toyota) Branch Pinrang" under the guidance of Mrs. Faridah, SE., M.Si, .AK, .ca as first counselor and Mr. Thanwain, SE ,. M.Si as supervisor II. Accounting Information Systems are very important in the sales function remembers every sales transaction must involve the responsibility of a few people within the company. To improve the handling of the sale of the company it needed an adequate internal cont...

  19. IMPACT OF UNETHICAL PRACTICES ON BUSINESS ENVIRONMENT: A CASE STUDY ON TOYOTA

    OpenAIRE

    Uzma Ehtesham; Asif Amin Kuchey

    2017-01-01

    Purpose: This paper tries to identify the unethical practice carried out by the Toyota. It also tries to examine the impact of these unethical practices on their respective employee performance, their employee relations, company credibility, and on the society. Lessons can be learned from these experiences and preventive measures can be applied across international borders to improve business conduct in other developing economies. Design / Methodology/ Approach-The present research paper ...

  20. Sistem Pakar Diagnosis Kerusakan Mobil Toyota Kijang LSX Menggunakan Metode Forward Chaining

    Directory of Open Access Journals (Sweden)

    Turnawan Turnawan

    2017-09-01

    Abstract Damage to the car was realized by the owner when the car is not operating properly or not as usual. Periodic maintenance needed each car to detect damage to what happened to the car. Many of the causes and signs as the car is not running properly, some of which car lights are not lit and have no idea why it happened, it is this which encourages the development of expert systems with forward chaining method  for detecting damage to the car. Especially for cars that are old and no longer manufactured, therefore the authors use a Toyota Kijang LSX as research objects. In this study, the authors designed so that the delivery of information can be done using any mobile device with the request from the user. The request will be processed in the system then the results will be sent back to the user with a display on a mobile device screen. This expert system application is made in the form of android application to allow users to access and resolve the problems associated quickly, anywhere and anytime.The expert system is able to provide optimal information of the user and the system of reciprocity to the owner of the vehicle Toyota Kijang LSX.   Keywords: Android, expert systems, Toyota Kijang LSX.

  1. Improving Papanicolaou test quality and reducing medical errors by using Toyota production system methods.

    Science.gov (United States)

    Raab, Stephen S; Andrew-Jaja, Carey; Condel, Jennifer L; Dabbs, David J

    2006-01-01

    The objective of the study was to determine whether the Toyota production system process improves Papanicolaou test quality and patient safety. An 8-month nonconcurrent cohort study that included 464 case and 639 control women who had a Papanicolaou test was performed. Office workflow was redesigned using Toyota production system methods by introducing a 1-by-1 continuous flow process. We measured the frequency of Papanicolaou tests without a transformation zone component, follow-up and Bethesda System diagnostic frequency of atypical squamous cells of undetermined significance, and diagnostic error frequency. After the intervention, the percentage of Papanicolaou tests lacking a transformation zone component decreased from 9.9% to 4.7% (P = .001). The percentage of Papanicolaou tests with a diagnosis of atypical squamous cells of undetermined significance decreased from 7.8% to 3.9% (P = .007). The frequency of error per correlating cytologic-histologic specimen pair decreased from 9.52% to 7.84%. The introduction of the Toyota production system process resulted in improved Papanicolaou test quality.

  2. DVD. Alar Niineväli soovitab "Tähevärav : Tõelaegas" / Alar Niineväli

    Index Scriptorium Estoniae

    Niineväli, Alar

    2008-01-01

    Esimene kahest otse DVD levisse läinud mängufilmist populaarse ulmeseriaali lõpuleviimiseks "Tähevärav: Tõelaegas" ("Stargate: The Ark of Truth") : režissöör Robert C. Cooper : Ameerika Ühendriigid - Kanada 2008

  3. On the design of a (H)EV steerable warning device using acoustic beam forming and advanced numerical acoustic simulation

    NARCIS (Netherlands)

    Van Genechten, B.; Vansant, K.; Berkhoff, Arthur P.

    2014-01-01

    This paper describes the simulation-based design methodology used in the eVADER project for the development of targeted acoustic warning devices for increased detectability of Hybrid and Electric Vehicles (HEVs) while, at the same time, reducing urban noise pollution. A key component of this system

  4. Population Movement and Virus Spreading: HEV Spreading in a Pilgrimage City, Mashhad in Northeast Iran; an Example.

    Science.gov (United States)

    Ahmadi Ghezeldasht, Sanaz; Miri, Rahele; Hedayatimoghadam, Mohamadreza; Shamsian, Aliakbar; Bidkhori, Hamidreza; Fathimoghadam, Fahad; Rezaee, Seyyed Abdorrahim

    2013-01-01

    Hepatitis E Virus (HEV) infection is a significant public health concern and responsible for large outbreaks of acute hepatitis in poor sanitary and living conditions. To investigate the impact of population movements on virus spreading, a large-scale population-based survey was performed in a pilgrimage- tourism area, the great Mashhad, capital city of Khorasan province. A cross-sectional study was carried out among 1582 randomly selected individuals from general population of Mashhad, north east of Iran, between May to September 2009. Serum samples were tested for total anti-HEV antibody using a specific enzyme linked immunoassay (ELISA) kit. The prevalence of HEV infection was 14.2% (225/1582) with a maximum of 25.5 % (14/55) in densely populated areas. The highest prevalence was observed in visitant areas (≥ 20%) near the holly shrine with crowded hotels and inns. The differences between these areas and other districts were statistically significant (P socio-economic status, Illiterate individuals were significantly at higher risk for infection than educated persons (P < 0.001). These findings demonstrated that, high prevalence of HEV is related to populated district, which can reach to the highest rate in hotels and inns close to visitants. Traditional sanitation and water supplying systems are the second important factor for the virus transmission. Therefore, it can be concluded that such areas need efficient surveillance systems to prevent the spreading of infectious diseases.

  5. Diagnosis of HEV infection by serological and real-time PCR assays: a study on acute non-A-C hepatitis collected from 2004 to 2010 in Italy

    Directory of Open Access Journals (Sweden)

    Candido Angela

    2012-06-01

    Full Text Available Abstract Background The impact of hepatitis E in developed countries, like Italy, still requires a clear definition. In the present study, we evaluated HEV infection in patients with acute non-A-C hepatitis by an approach comparing data from Real-time PCR and serological assays. Methods In a first analysis, sera from 52 patients hospitalized with a diagnosis of acute viral non-A-C hepatitis in Italy were tested by in-house Real-Time PCR assay for identification of Hepatitis E Virus (HEV RNA and by anti-HEV IgM and IgG assays. In a subsequent analysis, selected samples were evaluated by additional IgM tests to confirm diagnosis. Results Among the 52 samples, 21 showed positive results for all three markers (IgM, IgG and HEV RNA. One patient showed HEV RNA as single marker. Uncertain results were found in 8 samples while the remaining 22 were negative for all markers. Further analysis of the 8 undefined samples by additional IgM tests confirmed HEV infection in 1 patient. Overall, acute HEV infections were reliably identified in 23 (44.2% out of 52 patients. Conclusions In the present paper, we performed a study evaluating HEV infection in 52 sporadic non-A-C acute hepatitis cases. All samples were collected from 2004 to 2010 in Italy. By a diagnostic strategy based on genomic and serological assays we identified HEV infections in 23 out of 52 patients (44.2%, a percentage higher than previous estimates. Thus, the actual impact of HEV infections in Italy needs to be further evaluated on a national scale by a diagnostic strategy based on multiple and last generation assays.

  6. "Las claves del éxito de Toyota". LEAN, más que un conjunto de herramientas y técnicas

    OpenAIRE

    Toledano de Diego, Asier; Mañes Sierra, Nagore; García, Sergio Julián

    2009-01-01

    [ES] Cuando se habla de LEAN, inmediatamente se piensa en Toyota y en su continuo éxito. De ahí que hayan sido muchas las empresas que han intentado seguir su modelo: el TPS (Sistema de Producción Toyota) o el modelo LEAN, basado en él. Sin embargo, pocas lo han conseguido. El libro titulado «Las claves del éxito de Toyota», creemos que da la respuesta a través de catorce principios que comentaremos en este artículo. [EN] When speaking about LEAN, people immediately think about Toyota a...

  7. Construction of an infectious cDNA clone of avian hepatitis E virus (avian HEV) recovered from a clinically healthy chicken in the United States and characterization of its pathogenicity in specific-pathogen-free chickens.

    Science.gov (United States)

    Kwon, Hyuk Moo; LeRoith, Tanya; Pudupakam, R S; Pierson, F William; Huang, Yao-Wei; Dryman, Barbara A; Meng, Xiang-Jin

    2011-01-27

    A genetically distinct strain of avian hepatitis E virus (avian HEV-VA strain) was isolated from a healthy chicken in Virginia, and thus it is important to characterize and compare its pathogenicity with the prototype strain (avian HEV-prototype) isolated from a diseased chicken. Here we first constructed an infectious clone of the avian HEV-VA strain. Capped RNA transcripts from the avian HEV-VA clone were replication-competent after transfection of LMH chicken liver cells. Chickens inoculated intrahepatically with RNA transcripts of avian HEV-VA clone developed active infection as evidenced by fecal virus shedding, viremia, and seroconversion. To characterize the pathogenicity, RNA transcripts of both avian HEV-VA and avian HEV-prototype clones were intrahepatically inoculated into the livers of chickens. Avian HEV RNA was detected in feces, serum and bile samples from 10/10 avian HEV-VA-inoculated and 9/9 avian HEV-prototype-inoculated chickens although seroconversion occurred only in some chickens during the experimental period. The histopathological lesion scores were lower for avian HEV-VA group than avian HEV-prototype group in the liver at 3 and 5 weeks post-inoculation (wpi) and in the spleen at 3 wpi, although the differences were not statistically significant. The liver/body weight ratio, indicative of liver enlargement, of both avian HEV-VA and avian HEV-prototype groups were significantly higher than that of the control group at 5 wpi. Overall, the avian HEV-VA strain still induces histological liver lesions even though it was isolated from a healthy chicken. The results also showed that intrahepatic inoculation of chickens with RNA transcripts of avian HEV infectious clone may serve as an alternative for live virus in animal pathogenicity studies. Copyright © 2010 Elsevier B.V. All rights reserved.

  8. Serological and virological survey of hepatitis E virus (HEV) in animal reservoirs from Uruguay reveals elevated prevalences and a very close phylogenetic relationship between swine and human strains.

    Science.gov (United States)

    Mirazo, Santiago; Gardinali, Noemí R; Cecilia, D'Albora; Verger, Lorenzo; Ottonelli, Florencia; Ramos, Natalia; Castro, Gustavo; Pinto, Marcelo A; Ré, Viviana; Pisano, Belén; Lozano, Alejandra; de Oliveira, Jaqueline Mendes; Arbiza, Juan

    2018-01-01

    Hepatitis E virus (HEV) infection is an issue of public health concern in high-income and non-endemic countries. Increasing evidence supports the hypothesis of a zoonotic route as the main mode of infection in this epidemiological setting, since the transmission of genotypes HEV-3 and HEV-4 from reservoirs to humans has been demonstrated. In America, studies have confirmed the circulation of HEV in pig herds but the zoonotic role of wild boars has never been evaluated. Uruguay has a high burden of HEV- associated acute hepatitis, and a close phylogenetic relationship was observed among human HEV-3 strains and European isolates detected in swine. However in this context, swine herds have never been surveyed. Herein is reported a survey of HEV in swine herds, pigs at slaughter-house and free-living wild boar populations. Two-hundred and twenty sera and 150 liver tissue samples from domestic pigs, and 140 sera from wild boars were tested for HEV by ELISA and PCR-based approaches. All tested swine farms resulted seropositive with an overall rate of 46.8%. In turn, 22.1% of the wild boars had anti-HEV antibodies. HEV RNA was detected in 16.6% and 9.3% of liver samples from slaughter-age pigs and adult wild boars sera, respectively. Three strains from domestic pig were also amplified by nested-PCR approaches. By contrast, none of the positive samples obtained from wild boars could be confirmed by nested-PCR. Phylogenetic analysis revealed a very high nucleotide identity among swine strains and sequences obtained from humans in Uruguay. Results showed that HEV is widely distributed among swine herds in Uruguay. Additionally, this study evidences for the first time in the American continent that wild boar populations are a reservoir for HEV, though its zoonotic role remains to be elucidated. Altogether, data presented here suggest a high zoonotic risk of HEV transmission from swine to humans. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Further demonstration of the VRLA-type UltraBattery under medium-HEV duty and development of the flooded-type UltraBattery for micro-HEV applications

    Energy Technology Data Exchange (ETDEWEB)

    Furukawa, J.; Takada, T.; Monma, D. [The Furukawa Battery Co., Ltd., R and D Division, 23-6 Kuidesaku, Shimofunao-machi, Joban, Iwaki-city, 972-8501 (Japan); Lam, L.T. [CSIRO Energy Technology, Bayview Avenue, Clayton South, Vic. 3169 (Australia)

    2010-02-15

    The UltraBattery has been invented by the CSIRO Energy Technology in Australia and has been developed and produced by the Furukawa Battery Co., Ltd., Japan. This battery is a hybrid energy storage device which combines a super capacitor and a lead-acid battery in single unit cells, taking the best from both technologies without the need of extra, expensive electronic controls. The capacitor enhances the power and lifespan of the lead-acid battery as it acts as a buffer during high-rate discharging and charging, thus enabling it to provide and absorb charge rapidly during vehicle acceleration and braking. The laboratory results of the prototype valve-regulated UltraBatteries show that the capacity, power, available energy, cold cranking and self-discharge of these batteries have met, or exceeded, all the respective performance targets set for both minimum and maximum power-assist HEVs. The cycling performance of the UltraBatteries under micro-, mild- and full-HEV duties is at least four times longer than that of the state-of-the-art lead-acid batteries. Importantly, the cycling performance of UltraBatteries is proven to be comparable or even better than that of the Ni-MH cells. On the other hand, the field trial of UltraBatteries in the Honda Insight HEV shows that the vehicle has surpassed 170,000 km and the batteries are still in a healthy condition. Furthermore, the UltraBatteries demonstrate very good acceptance of the charge from regenerative braking even at high state-of-charge, e.g., 70% during driving. Therefore, no equalization charge is required for the UltraBatteries during field trial. The HEV powered by UltraBatteries gives slightly higher fuel consumption (cf., 4.16 with 4.05 L/100 km) and CO{sub 2} emissions (cf., 98.8 with 96 g km{sup -1}) compared with that by Ni-MH cells. There are no differences in driving experience between the Honda Insight powered by UltraBatteries and by Ni-MH cells. Given such comparable performance, the UltraBattery pack

  10. Renault, Volkswagen ja Toyota Baltimaade suurimad müügihitid / Tõnu Tramm

    Index Scriptorium Estoniae

    Tramm, Tõnu, 1968-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti 1. sept. lk. 11. Ülevaade Baltimaade 2004. aasta esimese seitsme kuu uute autode registreerimise statistikast. Diagramm ja tabelid: Eesti turuosa jätkuvalt Baltimaade suurim; Toyota Baltimaades ostetuim; Renault' müük kasvanud kõige rohkem; Eestis kasvas kõige enam Renault' müük; Lätis kasvas enim Hyundai müük; Leedus kasvas enim Mitsubishi müük; Juulis varastati välismaalastelt 24 autot. Vt. samas: Autovargad ihaldavad turistide autosid

  11. Learning from business: incorporating the Toyota Production System into nursing curricula.

    Science.gov (United States)

    Serembus, Joanne Farley; Meloy, Faye; Posmontier, Bobbie

    2012-12-01

    The faculty at Drexel University decided to investigate a new model to transform nursing education, aiming to produce a new skill set that would serve to improve the transition of nursing graduates from academic settings to practice, to better serve the needs of patients and reduce medical error. Faculty looked to the Toyota Production System (TPS), which has established credibility in industry and health care settings. TPS has demonstrated increased efficiency and effectiveness, reduced cost, and enhanced achievement of stated goals. Drexel University is the first academic institution to incorporate the principles of the TPS into nursing education. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Durability comparison of four different types of high-power batteries in HEV and their degradation mechanism analysis

    International Nuclear Information System (INIS)

    Yan, Dongxiang; Lu, Languang; Li, Zhe; Feng, Xuning; Ouyang, Minggao; Jiang, Fachao

    2016-01-01

    Highlights: • Utilize a realistic current profile for an HEV to study the degradation mechanism of batteries. • Compare the durability of four different types of high-power battery. • Degradation mechanisms of four different types of high-power battery are analyzed by IC curves. • The prognostic model is used to quantitatively clarify the aging mechanism of batteries. - Abstract: There are many types of high-power batteries used in HEVs, and their durabilities and degradation mechanisms are different. In this paper, four types of commercial high-power batteries, including two types of LTO/NCM lithium-ion battery from two different manufacturers, a C/LMO battery and a supercapacitor (SC), are studied. A durability test with a realistic current profile for an HEV is used so that the durability results more closely reflect real operating conditions than a general cycle life test. Incremental capacity (IC) curves are used to qualitatively analyze the degradation mechanism. To compensate for defects in the IC method, a prognosis model, using a genetic algorithm to reconstruct constant current charge voltage curves, is adopted to quantitatively identify the battery aging mechanism.

  13. Performance of a Nonlinear Real-Time Optimal Control System for HEVs/PHEVs during Car Following

    Directory of Open Access Journals (Sweden)

    Kaijiang Yu

    2014-01-01

    Full Text Available This paper presents a real-time optimal control approach for the energy management problem of hybrid electric vehicles (HEVs and plug-in hybrid electric vehicles (PHEVs with slope information during car following. The new features of this study are as follows. First, the proposed method can optimize the engine operating points and the driving profile simultaneously. Second, the proposed method gives the freedom of vehicle spacing between the preceding vehicle and the host vehicle. Third, using the HEV/PHEV property, the desired battery state of charge is designed according to the road slopes for better recuperation of free braking energy. Fourth, all of the vehicle operating modes engine charge, electric vehicle, motor assist and electric continuously variable transmission, and regenerative braking, can be realized using the proposed real-time optimal control approach. Computer simulation results are shown among the nonlinear real-time optimal control approach and the ADVISOR rule-based approach. The conclusion is that the nonlinear real-time optimal control approach is effective for the energy management problem of the HEV/PHEV system during car following.

  14. Pengaruh Pelaksanaan Penetapan Harga Produk terhadap Minat Konsumen (Kasus Penjualan Mobil Toyota Avanza pada PT. Agung Automall Cabang Pekanbaru)

    OpenAIRE

    Heriyanto, Meyzi; Fibrianti, Resi

    2014-01-01

    This research is a problem in any decline in consumer interest for buy a car Toyota Avanza, indicated by decline in sales by 2012 compared with 2011. As for the purpose of this research is to know the implementation of pricing and consumer interest against Toyota Avanza car on PT Agung Automall branch of Soweto as well as to know how the implementation of pricing products of consumer interest buying a car on PT. Supreme Avanza Automall branch of Soweto. Results of the study concluded that imp...

  15. 76 FR 65610 - Final Theft Data; Motor Vehicle Theft Prevention Standard

    Science.gov (United States)

    2011-10-24

    ......... S-CLASS 22 10,189 2.1592 34 GENERAL MOTORS..... CHEVROLET HHR...... 172 80,781 2.1292 35 TOYOTA... MOTOR CO...... LINCOLN TOWN CAR... 24 11,596 2.0697 39 TOYOTA AVALON 45 22,030 2.0427 40 NISSAN 350Z 1....7552 50 TOYOTA CAMRY/SOLARA....... 781 447,882 1.7438 51 TOYOTA COROLLA 632 363,515 1.7386 52 HYUNDAI...

  16. Pengaruh Sistem Pengapian Terhadap Produk Gas Buang yang Dihasilkan oleh Motor Toyota Type 5K

    Directory of Open Access Journals (Sweden)

    Paryono Paryono

    2009-02-01

    Full Text Available Salah platina dan elektronik pada satu faktor yang menyebabkan polusi udara di sekitar kita adalah gas buang hasil pembakaran bahan bakar dan udara yang ditimbulkan oleh banyaknya kendaraan di jalan raya. Selain itu dalam rangka era globalisasi semua produsen kendaraan bermotor dituntut untuk bersaing lebih ketat dalam memproduksi kendaraan yang praktis, ekonomis, dan selalu memperhatikan aspek lingkungan. Tujuan penelitian ini adalah untuk mengetahui perbedaan produk emisi gas buang yang teridiri dari carbon hidrogen, carbon monoksida, dan oksigen yang dihasilkan oleh kendaraan bermotor Toyota 5K yang menggunakan sistem pengapian saat putaran rendah, menengah, dan tinggi. Sebagai objek penelitian digunakan motor Toyota 5K. Hasil yang diperoleh dari pengujian menunjukkan bahwa putaran motor dan sistem pengapian ada iteraksi yang signifikan dengan F rasio = 96,966 pada p < 0,05 terhadap emisi gas buang HC dan F rasio = 12, 801 pada p < 0,05 terhadap emisi gas buang CO. Hal ini berarti bahwa pada berbagai putaran motor, produk emisi gas buang paa sistem pengapian elektronik lebih rendah daripada sistem pengapian konvensional.

  17. Toyota Prius Hybrid Plug-in Conversation and Battery Monitoring system

    Science.gov (United States)

    Unnikannan, Krishnanunni; McIntyre, Michael; Harper, Doug; Kessinger, Robert; Young, Megan; Lantham, Joseph

    2012-03-01

    The objective of the project was to analyze the performance of a Toyota Hybrid. We started off with a stock Toyota Prius and taking data by driving it in city and on the highway in a mixed pre-determined route. The batteries can be charged using standard 120V AC outlets. First phase of the project was to increase the performance of the car by installing 20 Lead (Pb) batteries in a plug-in kit. To improve the performance of the kit, a centralized battery monitoring system was installed. The battery monitoring system has two components, a custom data modules and a National Instruments CompactRIO. Each Pb battery has its own data module and all the data module are connected to the CompactRIO. The CompactRIO records differential voltage, current and temperature from all the 20 batteries. The LabVIEW software is dynamic and can be reconfigured to any number of batteries and real time data from the batteries can be monitored on a LabVIEW enabled machine.

  18. Waste minimization activities in Toyota Motor Corporation; Haikibutsu teigen eno torikumi jokyo

    Energy Technology Data Exchange (ETDEWEB)

    Taguchi, S.; Yamamoto, N.; Kurai, H. [Toyota Motor Corp., Aichi (Japan)

    1998-07-01

    Toyota`s waste reduction efforts based on a drive for dealing with the source of waste generation are introduced. For the propulsion of the policy for dealing directly with the origin of waste, it is necessary to convert the existing manufacturing processes that give high priority to product quality and low production cost into environmental impact reduction oriented processes. In particular, conversion of materials into those that are easier to recycle, technology for reducing defective products, technology for the completion of recycling within the process involved, and the simplification of all the processes are mentioned. For the cleaning job in the machining process, a detergent enhanced in oil/water separating capability is developed, and this prolongs doubly the detergent replacement period and decreases the waste liquid to a 1/4 or less of what the conventional method produces. For the handling of foundry sand that is yielded in great quantities, a flow classification system is developed to replace the conventional gravitational classifier, and the reusable coarse-grain sand in the collected dust which occupies approximately 70% of the whole waste is now recovered for reuse. In the vehicle body coating process, a newly-developed robot arm type coating system is developed, which halves the coating waste. 2 refs., 9 figs., 1 tab.

  19. Economic Sociology and the Theory of the Firm: Lessons from the "Toyota Momentum" in the History of Capitalism

    OpenAIRE

    HEIM, Stéphane

    2016-01-01

    This paper is a revised and expanded version of an editorial, "Toyota, victim of its Production System: why do social sciences still have much to learn from this firm?", published on February 1, 2017 in La Lettre du GIS-Réseau Asie et Pacifique (French and English).

  20. Battery Usage and Thermal Performance of the Toyota Prius and Honda Insight for Various Chassis Dynamometer Test Procedures: Preprint

    International Nuclear Information System (INIS)

    Kelly, K. J.; Mihalic, M.; Zolot, M.

    2001-01-01

    This study describes the results from the National Renewable Energy Laboratory's (NREL) chassis dynamometer testing of a 2000 model year Honda Insight and 2001 model year Toyota Prius. The tests were conducted for the purpose of evaluating the battery thermal performance, assessing the impact of air conditioning on fuel economy and emissions, and providing information for NREL's Advanced Vehicle Simulator (ADVISOR)

  1. Lean manufacturing and Toyota Production System terminology applied to the procurement of vascular stents in interventional radiology.

    Science.gov (United States)

    de Bucourt, Maximilian; Busse, Reinhard; Güttler, Felix; Wintzer, Christian; Collettini, Federico; Kloeters, Christian; Hamm, Bernd; Teichgräber, Ulf K

    2011-08-01

    OBJECTIVES: To apply the economic terminology of lean manufacturing and the Toyota Production System to the procurement of vascular stents in interventional radiology. METHODS: The economic- and process-driven terminology of lean manufacturing and the Toyota Production System is first presented, including information and product flow as well as value stream mapping (VSM), and then applied to an interdisciplinary setting of physicians, nurses and technicians from different medical departments to identify wastes in the process of endovascular stent procurement in interventional radiology. RESULTS: Using the so-called seven wastes approach of the Toyota Production System (waste of overproducing, waiting, transport, processing, inventory, motion and waste of defects and spoilage) as well as further waste characteristics (gross waste, process and method waste, and micro waste), wastes in the process of endovascular stent procurement in interventional radiology were identified and eliminated to create an overall smoother process from the procurement as well as from the medical perspective. CONCLUSION: Economic terminology of lean manufacturing and the Toyota Production System, especially VSM, can be used to visualise and better understand processes in the procurement of vascular stents in interventional radiology from an economic point of view.

  2. Robust equivalent consumption-based controllers for a dual-mode diesel parallel HEV

    International Nuclear Information System (INIS)

    Finesso, Roberto; Spessa, Ezio; Venditti, Mattia

    2016-01-01

    Highlights: • Non-plug-in dual-mode parallel hybrid architecture. • Cross-validation machine-learning for robust equivalent consumption-based controllers. • Optimal control strategy based on fuel consumption, NOx and battery aging. • Impact of different equivalent consumption definitions on HEV performance. • Correlation between vehicle braking energy and SOC variation in the traction stages. - Abstract: New equivalent consumption minimization strategy (ECMS) tools have been developed and applied to identify the optimal control strategy of a dual-mode parallel hybrid electric vehicle equipped with a compression-ignition engine. In this architecture, the electric machine is coupled to the engine through either a single-speed gearbox (torque-coupling) or a planetary gear set (speed-coupling). One of the main novelties of the present study concerns the definition of the instantaneous equivalent consumption (EC) function, which takes into account not only fuel consumption (FC) and the energy flow through the electric components, but also NO_x emissions, battery aging, and the battery SOC. The EC function has been trained using a cross-validation machine-learning technique, based on a genetic algorithm, where the training data set has been selected in order to maximize performances over a testing data set. The adoption of this technique, in conjunction with the new definition of EC, have led to the identification of very robust controllers, which provide an accurate control for different driving scenarios, even when the EC function is not specifically trained on the same missions over which it is tested. To this aim, a data set of fifty driving cycles and six user-defined missions, which cover a total distance of 70–100 km, has been considered as a training driving set. The ECMS controllers can be implemented in a vehicle control unit, and their performance has resulted to be close to that of a dynamic programming tool, which has here been used as benchmark

  3. Pengaruh Promosi, Harga Dan Pelayanan Terhadap Keputusan Pembelian Toyota Dyna Dengan Jenis USAha Sebagai Variabel Moderasi (Studi Kasus Konsumen PT. New Ratna Motor, Semarang)

    OpenAIRE

    Afifi, Fahmi Rezqa; Ngatno, Ngatno

    2016-01-01

    Goal of companies is become the market leader of their products. To achieve it, companies have to increase their sales volume. As Toyota brand holder in Central Java and DIY, PT. New Ratna Motor always tries to lead the market share in all car types, including two-tonnage vehicles (truck) class. Toyota Dyna becomes the favorite of Toyota in this class, which the competition in this class is tighter. Promotion, price, and service are some of important factors which can be related with consumer...

  4. Assessment of HAV and HEV Seroprevalence in Children Living in Post-Earthquake Camps from Duezce, Turkey

    International Nuclear Information System (INIS)

    Sencan, Irfan; Sahin, Idris; Kaya, Demet; Oksuz, Sukru; Yildirim, Mustafa

    2004-01-01

    The aim of the study was to investigate the prevalance of enterically transmitted hepatitis among children living in post-earthquake camps, and to assess the efficacy of the measurements during and after the disaster in Duezce and Golyaka. In the second half of 1999, North-western Turkey, was struck by two massive earthquakes in less than 3months. The first, on 17 August 1999, involving Golyaka, was struck, measuring between 7.4 and 7.8 on the Richter scale. Irregularity about providing clean water and necessary sanitary facilities were observed after the first earthquake because of confusion. The second quake, on 12 November 1999, which rated 7.2 on the Richter scale, shook Duezce. Necessary precautions were applied rapidly at the second quake about shelter, clean drinking water, food and control of distribution of the aids by government and civil aid organisations. Anti-HEV(IgG) and anti-HAV(IgG) antibodies were determined in 476 sera of the children who was living in six camps. HAV prevalence of the children who were living in Duezce and Golyaka temporary houses was 44.4 and 68.8% respectively, OR: 0.37, CI 95%: 0.22-0.61, p=0.0005. HEV prevalence of the children was 4.7 and 17.2% respectively, OR: 0.24, CI 95%: 0.11-0.51, p=0.0007. In conclusion, HAV and HEV prevalence of children were lower than that in endemic areas but higher than that in developed countries. This study has pointed out the importance of providing urgent need of the sufficient sanitary facilities after disasters for preventing or reducing the incidence of enterically transmitted hepatitis, especially in the regions which were at risk for various disasters. Essential precautions such as providing clean water and food supply must be taken and an emergency action plan for preventing the infectious disease must be prepared before disasters such as earthquakes

  5. Use of microPCM fluids as enhanced liquid coolants in automotive EV and HEV vehicles. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Mulligan, James C.; Gould, Richard D.

    2001-10-31

    Proof-of-concept experiments using a specific microPCM fluid that potentially can have an impact on the thermal management of automotive EV and HEV systems have been conducted. Samples of nominally 20-micron diameter microencapsulated octacosane and glycol/water coolant were prepared for testing. The melting/freezing characteristics of the fluid, as well as the viscosity, were determined. A bench scale pumped-loop thermal system was used to determine heat transfer coefficients and wall temperatures in the source heat exchanged. Comparisons were made which illustrate the enhancements of thermal performance, reductions of pumping power, and increases of heat transfer which occur with the microPCM fluid.

  6. Estimation of State of Charge of Lithium-Ion Batteries Used in HEV Using Robust Extended Kalman Filtering

    Directory of Open Access Journals (Sweden)

    Suleiman M. Sharkh

    2012-04-01

    Full Text Available A robust extended Kalman filter (EKF is proposed as a method for estimation of the state of charge (SOC of lithium-ion batteries used in hybrid electric vehicles (HEVs. An equivalent circuit model of the battery, including its electromotive force (EMF hysteresis characteristics and polarization characteristics is used. The effect of the robust EKF gain coefficient on SOC estimation is analyzed, and an optimized gain coefficient is determined to restrain battery terminal voltage from fluctuating. Experimental and simulation results are presented. SOC estimates using the standard EKF are compared with the proposed robust EKF algorithm to demonstrate the accuracy and precision of the latter for SOC estimation.

  7. Modifying the Toyota Production System for continuous performance improvement in an academic children's hospital.

    Science.gov (United States)

    Stapleton, F Bruder; Hendricks, James; Hagan, Patrick; DelBeccaro, Mark

    2009-08-01

    The Toyota Production System (TPS) has become a successful model for improving efficiency and eliminating errors in manufacturing processes. In an effort to provide patients and families with the highest quality clinical care, our academic children's hospital has modified the techniques of the TPS for a program in continuous performance improvement (CPI) and has expanded its application to educational and research programs. Over a period of years, physicians, nurses, residents, administrators, and hospital staff have become actively engaged in a culture of continuous performance improvement. This article provides background into the methods of CPI and describes examples of how we have applied these methods for improvement in clinical care, resident teaching, and research administration.

  8. Improving preanalytic processes using the principles of lean production (Toyota Production System).

    Science.gov (United States)

    Persoon, Thomas J; Zaleski, Sue; Frerichs, Janice

    2006-01-01

    The basic technologies used in preanalytic processes for chemistry tests have been mature for a long time, and improvements in preanalytic processes have lagged behind improvements in analytic and postanalytic processes. We describe our successful efforts to improve chemistry test turnaround time from a central laboratory by improving preanalytic processes, using existing resources and the principles of lean production. Our goal is to report 80% of chemistry tests in less than 1 hour and to no longer recognize a distinction between expedited and routine testing. We used principles of lean production (the Toyota Production System) to redesign preanalytic processes. The redesigned preanalytic process has fewer steps and uses 1-piece flow to move blood samples through the accessioning, centrifugation, and aliquoting processes. Median preanalytic processing time was reduced from 29 to 19 minutes, and the laboratory met the goal of reporting 80% of chemistry results in less than 1 hour for 11 consecutive months.

  9. Sistema Toyota de produção: mais do que simplesmente Just-in-Time

    OpenAIRE

    Ghinato,Paulo

    1995-01-01

    As interpretações acerca do Sistema Toyota de Produção (STP), apontando o Just-In-Time e o Kanban como sua essência, demostram um entendimento limitado de sua verdadeira abrangência e potencialidade. O STP está estruturado sobre a base da completa eliminação das perdas, tendo o JIT e a autonomação como seus dois pilares de sustentação. O Controle da Qualidade Zero Defeitos (CQZD) aparece, também, como elemento essencial para a operacionalização da autonomação e funcionalidade de todo o sistem...

  10. Plan estratégico 2010-2013 Toyota en USA

    OpenAIRE

    Justo Coloma, Ana Cecilia; Alvarado Barrantes, Jorge Augusto; Boza Dibos, Francisco Juan José

    2015-01-01

    El presente trabajo realiza un análisis estratégico para Toyota en USA, abarcando los siguientes aspectos: (i) Los antecedentes de la compañía, la descripción del negocio, el alcance geográfico, la visión, la misión y los valores corporativos; (ii) La evaluación externa del macroentorno, el nivel de atracción y el ciclo de vida de la industria, así como el perfil competitivo y (iii) La descripción y el análisis de la cadena de valor, los recursos y capacidades y la posición financiera. La pri...

  11. Sistema Toyota de produção: mais do que simplesmente Just-in-Time

    Directory of Open Access Journals (Sweden)

    Paulo Ghinato

    1995-12-01

    Full Text Available As interpretações acerca do Sistema Toyota de Produção (STP, apontando o Just-In-Time e o Kanban como sua essência, demostram um entendimento limitado de sua verdadeira abrangência e potencialidade. O STP está estruturado sobre a base da completa eliminação das perdas, tendo o JIT e a autonomação como seus dois pilares de sustentação. O Controle da Qualidade Zero Defeitos (CQZD aparece, também, como elemento essencial para a operacionalização da autonomação e funcionalidade de todo o sistema. Neste artigo, pretende-se apresentar um modelo que represente esta interpretação. Com este propósito, o modelo apresentado por Monden é adotado como ponto de partida, introduzindo-lhe, no entanto, significativas mudanças. Neste artigo, discute-se cada uma das relações mantidas pela autonomação e pelo CQZD com os diversos componentes do sistema.The interpretations of the Toyota Production System (TPS which point out to Just-In-Time (JIT and Kanban as its essence are evidence of restrictive understanding of its real reach and strength. The TPS has the "complete elimination of wastes " as its grounds and JIT and autonomation as its two pillars. Zero Defect Quality Control (ZDQC appears as essential support to the operation of autonomation and Systems working. In this paper it is proposed a model which may portray the above interpretation of TPS. On this purpose, the model proposed by Monden was taken up as a starting point. Nevertheless, it was necessary to introduce significant changes. It is also discussed the nature o@f links among autonomation, ZDCQ and all Systems components.

  12. Production of Hev b5 as a fluorescent biotin-binding tripartite fusion protein in insect cells

    International Nuclear Information System (INIS)

    Nordlund, Henri R.; Laitinen, Olli H.; Uotila, Sanna T.H.; Kulmala, Minna; Kalkkinen, Nisse; Kulomaa, Markku S.

    2005-01-01

    The presented green fluorescent protein and streptavidin core-based tripartite fusion system provides a simple and efficient way for the production of proteins fused to it in insect cells. This fusion protein forms a unique tag, which serves as a multipurpose device enabling easy optimization of production, one-step purification via streptavidin-biotin interaction, and visualization of the fusion protein during downstream processing and in applications. In the present study, we demonstrate the successful production, purification, and detection of a natural rubber latex allergen Hev b5 with this system. We also describe the production of another NRL allergen with the system, Hev b1, which formed large aggregates and gave small yields in purification. The aggregates were detected at early steps by microscopical inspection of the infected insect cells producing this protein. Therefore, this fusion system can also be utilized as a fast indicator of the solubility of the expressed fusion proteins and may therefore be extremely useful in high-throughput expression approaches

  13. Production of Hev b5 as a fluorescent biotin-binding tripartite fusion protein in insect cells.

    Science.gov (United States)

    Nordlund, Henri R; Laitinen, Olli H; Uotila, Sanna T H; Kulmala, Minna; Kalkkinen, Nisse; Kulomaa, Markku S

    2005-10-14

    The presented green fluorescent protein and streptavidin core-based tripartite fusion system provides a simple and efficient way for the production of proteins fused to it in insect cells. This fusion protein forms a unique tag, which serves as a multipurpose device enabling easy optimization of production, one-step purification via streptavidin-biotin interaction, and visualization of the fusion protein during downstream processing and in applications. In the present study, we demonstrate the successful production, purification, and detection of a natural rubber latex allergen Hev b5 with this system. We also describe the production of another NRL allergen with the system, Hev b1, which formed large aggregates and gave small yields in purification. The aggregates were detected at early steps by microscopical inspection of the infected insect cells producing this protein. Therefore, this fusion system can also be utilized as a fast indicator of the solubility of the expressed fusion proteins and may therefore be extremely useful in high-throughput expression approaches.

  14. Analysis the Influence of Marketing Mix and After Sales Service Towards Purchase Decision on Toyota Yaris at PT. Agung Automall Duri.

    OpenAIRE

    ibrahim, Restu; Setiawan, Heru Putra

    2014-01-01

    This study aimed to analyze the influence of the marketing mix which consisting of Price, Product, Promotion and After sales service towards purchase decision on Toyota Yaris at PT. Agung Automall Duri located on jl.Raya Dumai Km thriteen, number four Duri. The population in this study are the consumers who bought Toyota Yatis car at PT. Agung Automall in year two thousand eleven. The research conducted by using census method with members of thirty seven respondents. Data analyze using multip...

  15. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KONSUMEN DALAM MEMILIH MOBIL MERK TOYOTA RUSH PADA PT. HADJI KALLA CABANG URIP SUMIHARJO MAKASSAR

    OpenAIRE

    PRABUANA H.P, MOCH.

    2013-01-01

    2012 Penelitian ini bertujuan untuk menganalisis Pengaruh Faktor bauran Bauran pemasaran (marketing mix) terhadap keputusan pembelian mobil merek Toyota Rush pada PT. Hadji Kalla cabang Urip Sumiharjo Makassar. Data penelitian ini diperoleh dari kuisioner (primer) dan beberapa observasi serta wawancara langsung dengan pihak terkait dengan produk mobil Toyota Rush. Temuan penelitian ini menunjukkan bahwa variabel bauran pemasaran yang terdiri dari faktor Produk (kualitas), Harga, promosi, d...

  16. Structural analysis of the endogenous glycoallergen Hev b 2 (endo-β-1,3-glucanase) from Hevea brasiliensis and its recognition by human basophils

    Energy Technology Data Exchange (ETDEWEB)

    Rodríguez-Romero, Adela, E-mail: adela@unam.mx; Hernández-Santoyo, Alejandra; Fuentes-Silva, Deyanira [Universidad Nacional Autónoma de México, Circuito Exterior, CU, 04310 Coyoacán, DF (Mexico); Palomares, Laura A. [Universidad Nacional Autónoma de México, Apartado Postal 510-3, 62250 Cuernavaca, MOR (Mexico); Muñoz-Cruz, Samira; Yépez-Mulia, Lilian [Centro Médico Nacional Siglo XXI, IMSS, Avenida Cuauhtémoc 330, Colonia Doctores, Mexico, DF (Mexico); Orozco-Martínez, Socorro [Instituto Nacional de Pediatría, Insurgentes Sur 3700C, 04530 Cuicuilco, DF (Mexico); Universidad Nacional Autónoma de México, Circuito Exterior, CU, 04310 Coyoacán, DF (Mexico)

    2014-02-01

    This study describes the three-dimensional structure of the endogenous glycosylated allergen Hev b 2 (endo-β-1,3-glucanase), which exhibits three post-translational modifications that form a patch on the surface of the molecule that is proposed to be an allergenic IgE epitope. Endogenous glycosylated Hev b 2 (endo-β-1,3-glucanase) from Hevea brasiliensis is an important latex allergen that is recognized by IgE antibodies from patients who suffer from latex allergy. The carbohydrate moieties of Hev b 2 constitute a potentially important IgE-binding epitope that could be responsible for its cross-reactivity. Here, the structure of the endogenous isoform II of Hev b 2 that exhibits three post-translational modifications, including an N-terminal pyroglutamate and two glycosylation sites at Asn27 and at Asn314, is reported from two crystal polymorphs. These modifications form a patch on the surface of the molecule that is proposed to be one of the binding sites for IgE. A structure is also proposed for the most important N-glycan present in this protein as determined by digestion with specific enzymes. To analyze the role of the carbohydrate moieties in IgE antibody binding and in human basophil activation, the glycoallergen was enzymatically deglycosylated and evaluated. Time-lapse automated video microscopy of basophils stimulated with glycosylated Hev b 2 revealed basophil activation and degranulation. Immunological studies suggested that carbohydrates on Hev b 2 represent an allergenic IgE epitope. In addition, a dimer was found in each asymmetric unit that may reflect a regulatory mechanism of this plant defence protein.

  17. Analisis Stabilitas Arah Mobil Toyota Agya G dengan Variasi Jumlah Penumpang, Kecepatan Belok, Sudut Belok dan Kemiringan Melintang Jalan

    Directory of Open Access Journals (Sweden)

    Faisal Rahman

    2017-03-01

    Full Text Available Mobil jenis Low Cost Green Car (LCGC semakin banyak digunakan masyarakat karena harganya yang murah dan ramah lingkungan. Meski termasuk kendaraan dengan biaya produksi yang rendah, adanya analisis perilaku arah kendaraan tetap diperlukan untuk menjamin kenyamaan dan keamanan pengemudi. Pada penelitian ini, analisa slip, skid dan guling dilakukan untuk mengetahui stabilitas kendaraan jenis LCGC, yaitu Toyota Agya. Pengaruh jumlah penumpang, kecepatan, sudut belok dan kemiringan melintang jalan terhadap slip, skid dan guling juga diperhitungkan. Sebagai komparatif studi, uji jalan dilakukan untuk mendapatkan koefisien understeer dan mengetahui kecepatan kendaraan dalam kondisi skid. Hasil penelitian menunjukkan bahwa mobil Toyota Agya mengalami kondisi stabilitas paling baik ketika dinaiki oleh 2 orang penumpang dengan sudut kemiringan melintang jalan 5.7°. Sedangkan kecepatan maksimum kendaraan tidak terguling terjadi pada kecepatan 94,987 km/jam untuk sudut belok 5° dan pada kecepatan 46,585 km/jam sudut belok 25°.

  18. Influence of Product Quality, Brand Image and Price Concerning Automobile Buying Decision of Toyota Avanza at PT. Nasmoco Majapahit Semarang

    OpenAIRE

    Putra, Arya Willis Nugraha; Waluyo, Handoyo Djoko; Nugraha, Hari Susanta

    2015-01-01

    This research was based on rapid automotive sector business development, especially automobile. Specifically, this research was discuss about automobile buying of Toyota Avanza brand at PT Nasmoco Majapahit Semarang during 2011 - 2014 keep have sale descending and it's sale target. If that case wasn't improve and solve, probably will presence problem for PT. Nasmoco Majapahit Semarang next.Aim of this research was to found product quality, brand image and price concerning automobile buying de...

  19. The motivation for strategic alliance formation: A case study between FAW-Volkswagen and FAW-Toyota

    OpenAIRE

    CHEN, L

    2009-01-01

    This paper investigates the concept of strategic alliance, motivations for strategic alliances formation and criteria for selecting strategic partners. At the same time, it integrates present situations of the international and domestic automobile industries. By analysis and comparison of motives between strategic alliance of FAW-Volkswagen and that of FAW-Toyota, it sums up reasons of China's automobile industry joining strategic alliances and problems that will occur. This paper aims at pro...

  20. Analisis Kenyamanan Serta Redesain Pegas Suspensi Mobil Toyota Fortuner 4.0 V6 SR (AT 4x4

    Directory of Open Access Journals (Sweden)

    Puja Priyambada

    2017-01-01

    Full Text Available Perkembangan dunia otomotif mengalami kemajuan yang sangat pesat. Seiring dengan perkembangan  tersebut kualitas kenyamanan kendaraan merupakan faktor yang harus diperhatikan. Dalam upaya meningkatkan kualitas kenyamanan kendaraan dilakukan pengembangan dalam sistem suspensi. Hal ini yang mendasari penulis untuk melakukan penelitian terkait suspensi mobil Toyota Fortuner 4.0 V6 SR. Pada penelitian ini, terdapat dua tahap, yakni tahap pengujian dan tahap analisis. Tahap pengujian untuk mendapatkan persentase road holding yang digunakan dalam menentukan kriteria keamanan kendaraan. Pada tahap analisis dilakukan simulasi untuk mengetahui percepatan rms yang dialami penumpang dengan pemodelan Half Car memanjang. Selanjutnya dilakukan perancangan ulang pegas suspensi yang lebih baik dari segi keamanan dan kenyamanan. Dari penelitian ini diketahui bahwa desain dari mobil Toyota Fortuner mengutamakan kenyamanan untuk penggunaan di jalan perkotaan. Berdasarkan standar ISO 2631 menunjukkan bahwa respon suspensi redesain untuk jalan perkotaan menghasilkan kenyamanan yang lebih baik daripada suspensi aktual. Berdasarkan kriteria keamanan BEISSBARTH dari hasil pengujian menunjukkan bahwa suspensi mobil Toyota Fortuner termasuk dalam kategori kurang baik sedangkan hasil simulasi untuk suspensi aktual dan redesain termasuk dalam kategori cukup baik. Dari hasil penelitian didapatkan kekakuan pegas untuk suspensi depan (ksf = 44631,61 N/m dan (ksr = 53500 N/m untuk suspensi belakang.

  1. Experimental investigation on the feasibility of heat pipe cooling for HEV/EV lithium-ion battery

    International Nuclear Information System (INIS)

    Tran, Thanh-Ha; Harmand, Souad; Desmet, Bernard; Filangi, Sebastien

    2014-01-01

    In this paper, the use of flat heat pipe as an effective and low-energy device to mitigate the temperature of a battery module designed for a HEV application was investigated. For this purpose, nominal heat flux generated by a battery module was reproduced and applied to a flat heat pipe cooling system. The thermal performance of the flat heat pipe cooling system was compared with that of a conventional heat sink under various cooling conditions and under several inclined positions. The results show that adding heat pipe reduced the thermal resistance of a common heat sink of 30% under natural convection and 20% under low air velocity cooling. Consequently, the cell temperature was kept below 50 °C, which cannot be achieved using heat sink. According to the space allocated for the battery pack in the vehicle, flat heat pipe can be used in vertical or horizontal position. Furthermore, flat heat pipe works efficiently under different grade road conditions. The transient behaviour of the flat heat pipe was also studied under high frequency and large amplitude variable input power. The flat heat pipe was found to handle more efficiently instant increases of the heat flux than the conventional heat sink. -- Highlights: • Constant heat flux was applied to a flat heat pipe cooling system. • Its thermal performance was compared with that of a heat sink under several cooling conditions. • The influence of the inclination was evaluated. • The heat pipe transient behaviour was also studied under variable input power. • Heat pipe was found to be an effective and low-energy solution for HEV/EV battery cooling

  2. Applying Toyota production system techniques for medication delivery: improving hospital safety and efficiency.

    Science.gov (United States)

    Newell, Terry L; Steinmetz-Malato, Laura L; Van Dyke, Deborah L

    2011-01-01

    The inpatient medication delivery system used at a large regional acute care hospital in the Midwest had become antiquated and inefficient. The existing 24-hr medication cart-fill exchange process with delivery to the patients' bedside did not always provide ordered medications to the nursing units when they were needed. In 2007 the principles of the Toyota Production System (TPS) were applied to the system. Project objectives were to improve medication safety and reduce the time needed for nurses to retrieve patient medications. A multidisciplinary team was formed that included representatives from nursing, pharmacy, informatics, quality, and various operational support departments. Team members were educated and trained in the tools and techniques of TPS, and then designed and implemented a new pull system benchmarking the TPS Ideal State model. The newly installed process, providing just-in-time medication availability, has measurably improved delivery processes as well as patient safety and satisfaction. Other positive outcomes have included improved nursing satisfaction, reduced nursing wait time for delivered medications, and improved efficiency in the pharmacy. After a successful pilot on two nursing units, the system is being extended to the rest of the hospital. © 2010 National Association for Healthcare Quality.

  3. Applying the Toyota Production System: using a patient safety alert system to reduce error.

    Science.gov (United States)

    Furman, Cathie; Caplan, Robert

    2007-07-01

    In 2002, Virginia Mason Medical Center (VMMC) adapted the Toyota Production System, also known as lean manufacturing. To translate the techniques of zero defects and stopping the line into health care, the Patient Safety Alert (PSA) system requires any employee who encounters a situation that is likely to harm a patient to make an immediate report and to cease any activity that could cause further harm (stopping the line). IMPLEMENTING THE PSA SYSTEM--STOPPING THE LINE: If any VMMC employee's practice or conduct is deemed capable of causing harm to a patient, a PSA can cause that person to be stopped from working until the problem is resolved. A policy statement, senior executive commitment, dedicated resources, a 24-hour hotline, and communication were all key features of implementation. As of December 2006, 6,112 PSA reports were received: 20% from managers, 8% from physicians, 44% from nurses, and 23% from nonclinical support personnel, for example. The number of reports received per month increased from an average of 3 in 2002 to 285 in 2006. Most reports were processed within 24 hours and were resolved within 2 to 3 weeks. Implementing the PSA system has drastically increased the number of safety concerns that are resolved at VMMC, while drastically reducing the time it takes to resolve them. Transparent discussion and feedback have helped promote staff acceptance and participation.

  4. The Toyota Production Systems fundamental nature at selected South African organisations A learning perspective

    Directory of Open Access Journals (Sweden)

    Nortje, F. D.

    2013-05-01

    Full Text Available The Toyota Production System (TPS has been cited as being the pinnacle of continuous improvement approaches in manufacturing organisations, and many models of the TPS are well known. However, some authors question the effectiveness of established approaches, and propose Batesons theory of learning [1] to be an effective way to explain phenomena like the TPS. This paper investigates the degree to which TPS elements are found in selected South African organisations. It constructs a model of the TPS using Bateson's theory of learning as a framework. The adoption of TPS elements is investigated through multiple qualitative case studies in seven organisations. The analysis follows a clustering and cross-case approach combined with pattern matching. While elements vary in their use, the selected organisations practise the TPS substantially less than the model advocates, with the model being least practised in low volume job/batch manufacturing. Product-process differences and higher levels of the TPS model may clarify peculiar outcomes.

  5. Toyota's new single-chip microcomputer based engine and transmission control system

    Energy Technology Data Exchange (ETDEWEB)

    Kawamura, T.; Kawai, M.; Aoki, K.; Tamaki, K.; Sugawara, M.

    1985-01-01

    Toyota succeeded in the fall of 1984 in manufacturing a complex engine and transmission control system using a newly developed single-chip microcomputer. This microcomputer, equipped with an 8K-byte ROM (Read Only Memory) and a 256-byte RAM (Random Access Memory), a powerful real time processing function, and a high-speed optimum instruction set, is better suited for automobiles. Application of the latest CMOS technology has enabled lower power consumption and improved noise immunity. The new system, which includes a new function; the electronic spark advance with knock control in addition to the conventional sophisticated system, has greatly improved the performance and driveability of vehicles. The newly designed electronic control unit (ECU) has been greatly improved in reliability and has not changed in its size with the adoption of the highly integrated new microcomputer, which is due to the fact that it uses fewer LSIs (Large Scale Integrated circuits) than the conventional ECU, although it includes the great additional function.

  6. OPTIMASI DAYA MESIN DAN KONSUMSI BAHAN BAKAR MESIN TOYOTA SERI 5K MELALUI PENGGUNAAN PENGAPIAN BOOSTER

    Directory of Open Access Journals (Sweden)

    Mardani Ali Sera

    2015-10-01

    Full Text Available Proses pembakaran adalah proses secara fisik yang terjadi di dalam silinder. Proses pembakaran dimulai pada saat busi memercikkan bunga api hingga terjadi proses pembakaran. Dalam penelitian ini digunakan metode eksperimen yaitu membandingkan daya dan konsumsi bahan bakar antara pengapian standar dengan pengapian menggunakan booster. Berdasarkan data hasil uji coba perbandingan antara sistem pengapian standar dengan pengapian yang menggunakan booster dengan objek penelitian mesin Toyota seri 5K diketahui adanya kenaikan 2.61% daya menjadi 27.723 kW dari 27.17 kW antara sistem pengapian standar dengan pengapian yang menggunakan booster pada putaran mesin 2400 rpm. Sedangkan prosentase kenaikan rerata daya sebesar 2.79 %. Penggunaan booster juga membuat penggunaan konsumsi bahan bakar spesifik (sfc antara sistem pengapian standar dengan pengapian yang menggunakan booster. Prosentase penurunan rerata konsumsi bahan bakar spesifik (sfc sebesar 6.99%. Pada sistem pengapian yang menggunakan booster, sfc minimum sebesar 0.219 kg/kWh pada putaran mesin 2200 rpm. Pada pengapian standar sfc minimum sebesar 0.231 kg/kWh pada putaran mesin 2400 rpm.

  7. Relationship Between Storm Hydrograph Components and Subsurface Flow Processes in a Hilly Headwater Basin, Toyota, Japan

    Science.gov (United States)

    Tsujimura, M.; Asai, K.; Takei, R.

    2001-05-01

    Temporal and spatial distribution of tracer elements and subsurface flow processes were investigated to study relationship between storm hydrograph components and behavior of subsurface water in a headwater catchment of Toyota Hill, Aichi prefecture, central Japan. The catchment has an area of 0.857 ha with an altitude of 60 to 100 m, and is underlain by granite. The soil depth revealed by sounding test ranges from 0.5 to 4.0 m. Rain, stream, soil and ground waters were sampled once in a week, and the stream water was sampled at 5 to 60 minute intervals during rainstorms. The pressure head of subsurface water was monitored using tensiometers and piezometers nests, and the stream flow was monitored using V-notch weir. The stable isotopic ratios of deuterium and oxygen 18 and inorganic ion concentrations were determined on all water samples. The oxygen 18 isotopic ratio in stream water decreased with rainfall during the rainstorms. The ratio of event water component to the total runoff water at the peak discharge ranged from 16 to 92 %, and the event water ratio correlated with the peak discharge rate and rainfall intensity. The tesiometric data showed that the shallow subsurface water with low isotopic ratios at the lower slope discharged directly to the stream during the heavy rainstorms. The shallow subsurface flow at the lower slope and overland flow on the raiparian zone contributed much to the stream water chemistry during heavy rainstorms.

  8. PENGARUH RELATIONSHIP MARKETING STRATEGY DAN KUALITAS PELAYANAN TERHADAP KEPUASAN PELANGGAN BENGKEL MOBIL TOYOTA

    Directory of Open Access Journals (Sweden)

    Marietje Carolien Nanulaitta

    2008-10-01

    Full Text Available The background of this research was customer relationship marketing and service quality of Firms have accepted that customer retention is even more profitable than customer attraction and we can observe the interest of firms in adopting relationship marketing principles and designing strategies to develop close and long-lasting relationships with the most profitable customers. The objective of the analysis of marketing activities and programs implemented in order to establish, develop, and maintain relationships with customers and the impact these activities have on the firm performance. The design of this research applies to Toyota Car Repair and the questionnaires were spreaded away to 110 respondents. The Likert-scale for the 5 point measurement which means strongly agree and 1 point is for strongly disagree. Data analysis used in this research was multiple regression. The result of this research concludes that relationship marketing strategy and service quality in car repair significantly affect to customer satisfaction. Keywords: Relationship marketing strategy, Service quality, Customer satisfaction

  9. Simulation-based design of a steerable acoustic warning device to increase (H)EV detectability while reducing urban noise pollution

    NARCIS (Netherlands)

    Van Genechten, B.; Berkhoff, Arthur P.

    2014-01-01

    This paper describes the simulation-based design methodology used in the eVADER project for the development of targeted acoustic warning devices for increased detectability of Hybrid and Electric Vehicles (HEVs) while, at the same time, reducing urban noise pollution compared to conventional

  10. 77 FR 38024 - Preliminary Theft Data; Motor Vehicle Theft Prevention Standard

    Science.gov (United States)

    2012-06-26

    ............ SEBRING......... 130 43,022 3.0217 8 TOYOTA LEXUS SC........ 1 335 2.9851 9 CHRYSLER......... DODGE...,199 2.1822 24 TOYOTA CAMRY/SOLARA.... 691 317,754 2.1746 25 GENERAL MOTORS... CHEVROLET MALIBU 381 183...... SATURN VUE...... 4 2,904 1.3774 47 TOYOTA 4RUNNER......... 18 13,345 1.3488 48 NISSAN MAXIMA 89 66,639 1...

  11. 77 FR 58500 - Final Theft Data; Motor Vehicle Theft Prevention Standard

    Science.gov (United States)

    2012-09-21

    ....0217 8 TOYOTA LEXUS SC 1 335 2.9851 9 CHRYSLER DODGE AVENGER....... 197 67,604 2.9140 10 KIA RIO 55 18....1822 24 TOYOTA CAMRY/SOLARA........ 691 317,754 2.1746 25 GENERAL MOTORS...... CHEVROLET MALIBU.... 381......... SATURN VUE 4 2,904 1.3774 47 TOYOTA 4RUNNER 18 13,345 1.3488 48 NISSAN MAXIMA 89 66,639 1.3356 49 NISSAN...

  12. Improving patient care in cardiac surgery using Toyota production system based methodology.

    Science.gov (United States)

    Culig, Michael H; Kunkle, Richard F; Frndak, Diane C; Grunden, Naida; Maher, Thomas D; Magovern, George J

    2011-02-01

    A new cardiac surgery program was developed in a community hospital setting using the operational excellence (OE) method, which is based on the principles of the Toyota production system. The initial results of the first 409 heart operations, performed over the 28 months between March 1, 2008, and June 30, 2010, are presented. Operational excellence methodology was taught to the cardiac surgery team. Coaching started 2 months before the opening of the program and continued for 24 months. Of the 409 cases presented, 253 were isolated coronary artery bypass graft operations. One operative death occurred. According to the database maintained by The Society of Thoracic Surgeons, the risk-adjusted operative mortality rate was 61% lower than the regional rate. Likewise, the risk-adjusted rate of major complications was 57% lower than The Society of Thoracic Surgeons regional rate. Daily solution to determine cause was attempted on 923 distinct perioperative problems by all team members. Using the cost of complications as described by Speir and coworkers, avoiding predicted complications resulted in a savings of at least $884,900 as compared with the regional average. By the systematic use of a real time, highly formatted problem-solving methodology, processes of care improved daily. Using carefully disciplined teamwork, reliable implementation of evidence-based protocols was realized by empowering the front line to make improvements. Low rates of complications were observed, and a cost savings of $3,497 per each case of isolated coronary artery bypass graft was realized. Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  13. Applying Toyota Production System principles to a psychiatric hospital: making transfers safer and more timely.

    Science.gov (United States)

    Young, John Q; Wachter, Robert M

    2009-09-01

    Health care organizations have increasingly embraced industrial methods, such as the Toyota Production System (TPS), to improve quality, safety, timeliness, and efficiency. However, the use of such methods in psychiatric hospitals has been limited. A psychiatric hospital applied TPS principles to patient transfers to the outpatient medication management clinics (MMCs) from all other inpatient and outpatient services within the hospital's system. Sources of error and delay were identified, and a new process was designed to improve timely access (measured by elapsed time from request for transfer to scheduling of an appointment and to the actual visit) and patient safety by decreasing communication errors (measured by number of failed transfers). Complexity was substantially reduced, with one streamlined pathway replacing five distinct and more complicated pathways. To assess sustainability, the postintervention period was divided into Period 1 (first 12 months) and Period 2 (next 24 months). Time required to process the transfer and schedule the first appointment was reduced by 74.1% in Period 1 (p < .001) and by an additional 52.7% in Period 2 (p < .0001) for an overall reduction of 87% (p < .0001). Similarly, time to the actual appointment was reduced 31.2% in Period 1 (p < .0001), but was stable in Period 2 (p = .48). The number of transfers per month successfully processed and scheduled increased 95% in the postintervention period compared with the pre-implementation period (p = .015). Finally, data for failed transfers were only available for the postintervention period, and the rate decreased 89% in Period 2 compared with Period 1 (p = .017). The application of TPS principles enhanced access and safety through marked and sustained improvements in the transfer process's timeliness and reliability. Almost all transfer processes have now been standardized.

  14. Toyota's innovative concept for a SI direct fuel injection system

    Energy Technology Data Exchange (ETDEWEB)

    Matsumura, E.; Kanda, M.; Hattori, F. [Toyota Motor Corporation, Shizuoka (Japan)

    2013-08-01

    To reduce environmental footprint of vehicle, demands have been intensifying for gasoline engines with lower fuel consumption, improved power performance, and lower emissions. The adoption of direct injection technology is rapidly expanding because it is an efficient way to achieve these targets. Originally, gasoline direct injection engines were designed to allow stratified lean combustion, which has a significant fuel consumption reduction effect. However, as exhaust gas emission regulations have become more stringent, the combustion strategy of most gasoline direct injection engines was changed to homogeneous stoichiometric combustion. Stratified lean combustion can nevertheless be used during catalyst heat up phase to fasten it and reduce pollutant emissions. In addition, exhaust gas recirculation (EGR), widely used in Diesel combustion, can also be used in gasoline engine to further reduce fuel consumption by reducing fuel requirement to maintain stoichiometric combustion. Regulations covering the emission of particulate matter (PM), which is an issue of direct injection, have also been strengthened, such as by the introduction of particle number restrictions in Europe. Based on this background, this article introduces the new Toyota direct injection (D-4S) concept that was developed to respond to such requirements. In this concept, combustion speed and air-fuel mixture homogeneity were improved by active usage of spray jets to strengthen the in-cylinder flow. The PM number and oil dilution were significantly reduced by usage of a thin fan-shaped spray formed by a slit nozzle. In addition, this developed slit nozzle has high potential to avoid deposit build-up. Moreover, fast catalyst warming up performance was secured to achieve a low level of emissions compatible with the super ultra low emission vehicle (SULEV) standards in North America. (orig.)

  15. Toronto hybrid taxi pilot

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, M. [CrossChasm Technologies, Cambridge, ON (Canada); Marans, B. [Toronto Atmospheric Fund, ON (Canada)

    2009-10-15

    This paper provided details of a hybrid taxi pilot program conducted to compare the on-road performance of Toyota Camry hybrid vehicles against conventional vehicles over a 1-year period in order to determine the business case and air emission reductions associated with the use of hybrid taxi cabs. Over 750,000 km worth of fuel consumption was captured from 10 Toyota Camry hybrids, a Toyota Prius, and 5 non-hybrid Camry vehicles over an 18-month period. The average real world fuel consumption for the taxis demonstrated that the Toyota Prius has the lowest cost of ownership, while the non-hybrid Camry has the highest cost of ownership. Carbon dioxide (CO{sub 2}) reductions associated with the 10 Camry hybrid taxis were calculated at 236 tonnes over a 7-year taxi service life. Results suggested that the conversion of Toronto's 5680 taxis would yield annual CO{sub 2} emission reductions of over 19,000 tonnes. All hybrid purchasers identified themselves as highly likely to purchase a hybrid again. 5 tabs., 9 figs.

  16. Toronto hybrid taxi pilot

    International Nuclear Information System (INIS)

    Stevens, M.; Marans, B.

    2009-10-01

    This paper provided details of a hybrid taxi pilot program conducted to compare the on-road performance of Toyota Camry hybrid vehicles against conventional vehicles over a 1-year period in order to determine the business case and air emission reductions associated with the use of hybrid taxi cabs. Over 750,000 km worth of fuel consumption was captured from 10 Toyota Camry hybrids, a Toyota Prius, and 5 non-hybrid Camry vehicles over an 18-month period. The average real world fuel consumption for the taxis demonstrated that the Toyota Prius has the lowest cost of ownership, while the non-hybrid Camry has the highest cost of ownership. Carbon dioxide (CO 2 ) reductions associated with the 10 Camry hybrid taxis were calculated at 236 tonnes over a 7-year taxi service life. Results suggested that the conversion of Toronto's 5680 taxis would yield annual CO 2 emission reductions of over 19,000 tonnes. All hybrid purchasers identified themselves as highly likely to purchase a hybrid again. 5 tabs., 9 figs.

  17. Performance Analysis and Simulation of a Novel Brushless Double Rotor Machine for Power-Split HEV Applications

    Directory of Open Access Journals (Sweden)

    Jingang Bai

    2012-01-01

    Full Text Available A new type of brushless double rotor machine (BDRM is proposed in this paper. The BDRM is an important component in compound-structure permanent-magnet synchronous machine (CS-PMSM systems, which are promising for power-split hybrid electric vehicle (HEV applications. The BDRM can realize the speed adjustment between claw-pole rotor and permanent-magnet rotor without brushes and slip rings. The structural characteristics of the BDRM are described and its magnetic circuit model is built. Reactance parameters of the BDRM are deduced by an analytical method. It is found that the size characteristics of the BDRM are different from those of conventional machines. The new sizing and torque equations are analyzed and the theoretical results are used in the optimization process. Studies of the analytical magnetic circuit and finite element method (FEM model show that the BDRM tends to have high leakage flux and low power factor, and then the method to obtain high power factor is discussed. Furthermore, a practical methodology of the BDRM design is developed, which includes an analytical tool, 2D field calculation and performance evaluation by 3D field calculation. Finally, different topologies of the BDRM are compared and an optimum prototype is designed.

  18. Loss for rupture in gondola: an analysis of Toyota Production System in food industry and retail supermarket

    Directory of Open Access Journals (Sweden)

    Claralucia Prates Machado

    2014-05-01

    Full Text Available Perdas em uma cadeia produtiva representam atividades de processamento, fabricação, comercializa- ção, desnecessárias para o êxito dos negócios. Realizou-se uma análise entre as Sete Perdas do Sistema Toyota de Produção (STP, a perda por má formação no mix de produto e pela perda por ruptura em gôndola. Tendo como objetos de estudo uma indústria alimentícia e uma rede de supermercados. Adotou-se como metodologia a pesquisa exploratória, qualitativa com um estudo de caso através de entrevista semi-estruturada. Verificou-se a importância do combate à perda por ruptura dado seu impacto negativo junto aos consumidores e os reflexos em relação à indústria e varejo.

  19. Pragmatic evaluation of the Toyota Production System (TPS analysis procedure for problem solving with entry-level nurses

    Directory of Open Access Journals (Sweden)

    Lukasz Maciej Mazur

    2008-12-01

    Full Text Available Medication errors occurring in hospitals are a growing national concern. These medication errors and their related costs (or wastes are seen as major factors leading to increased patient safety risks and increased waste in the hospital setting.  This article presents a study in which sixteen entry-level nurses utilized a Toyota Production System (TPS analysis procedure to solve medication delivery problems at one community hospital. The objective of this research was to study and evaluate the TPS analysis procedure for problem solving with entry-level nurses. Personal journals, focus group discussions, and a survey study were used to collect data about entry-level nurses’ perceptions of using the TPS problem solving approach to study medication delivery. A regression analysis was used to identify characteristics that enhance problem solving efforts. In addition, propositions for effective problem solving by entry-level nurses to aid in the reduction of medication errors in healthcare delivery settings are offered.

  20. Toyota drivers' experiences with Dynamic Radar Cruise Control, Pre-Collision System, and Lane-Keeping Assist.

    Science.gov (United States)

    Eichelberger, Angela H; McCartt, Anne T

    2016-02-01

    Advanced crash avoidance and driver assistance technologies potentially can prevent or mitigate many crashes. Previous surveys with drivers have found favorable opinions for many advanced technologies; however, these surveys are not necessarily representative of all drivers or all systems. As the technologies spread throughout the vehicle fleet, it is important to continue studying driver acceptance and use of them. This study focused on 2010-2013 Toyota Sienna and Prius models that were equipped with adaptive cruise control, forward collision avoidance, and lane departure warning and prevention (Prius models only). Telephone interviews were conducted in summer 2013 with 183 owners of vehicles with these technologies. About 9 in 10 respondents wanted adaptive cruise control and forward collision avoidance on their next vehicle, and 71% wanted lane departure warning/prevention again. Males and females reported some differences in their experiences with the systems; for example, males were more likely to have turned on lane departure warning/prevention than females, and when using this system, males reported more frequent warnings than did females. Relative to older drivers, drivers age 40 and younger were more likely to have seen or heard a forward collision warning. Consistent with the results in previous surveys of owners of luxury vehicles, the present survey found that driver acceptance of the technologies was high, although less so for lane departure warning/prevention. Experiences with the Toyota systems differed by driver age and gender to a greater degree than in previous surveys, suggesting that the responses of drivers may begin to differ as crash avoidance technology becomes available on a wider variety of vehicles. Crash avoidance technologies potentially can prevent or mitigate many crashes, but their success depends in part on driver acceptance. These systems will be effective only to the extent that drivers use them. Copyright © 2015 Elsevier Ltd and

  1. A Comprehensive Study of Neutralizing Antigenic Sites on the Hepatitis E Virus (HEV) Capsid by Constructing, Clustering, and Characterizing a Tool Box*

    Science.gov (United States)

    Zhao, Min; Li, Xiao-Jing; Tang, Zi-Min; Yang, Fan; Wang, Si-Ling; Cai, Wei; Zhang, Ke; Xia, Ning-Shao; Zheng, Zi-Zheng

    2015-01-01

    The hepatitis E virus (HEV) ORF2 encodes a single structural capsid protein. The E2s domain (amino acids 459–606) of the capsid protein has been identified as the major immune target. All identified neutralizing epitopes are located on this domain; however, a comprehensive characterization of antigenic sites on the domain is lacking due to its high degree of conformation dependence. Here, we used the statistical software SPSS to analyze cELISA (competitive ELISA) data to classify monoclonal antibodies (mAbs), which recognized conformational epitopes on E2s domain. Using this novel analysis method, we identified various conformational mAbs that recognized the E2s domain. These mAbs were distributed into 6 independent groups, suggesting the presence of at least 6 epitopes. Twelve representative mAbs covering the six groups were selected as a tool box to further map functional antigenic sites on the E2s domain. By combining functional and location information of the 12 representative mAbs, this study provided a complete picture of potential neutralizing epitope regions and immune-dominant determinants on E2s domain. One epitope region is located on top of the E2s domain close to the monomer interface; the other is located on the monomer side of the E2s dimer around the groove zone. Besides, two non-neutralizing epitopes were also identified on E2s domain that did not stimulate neutralizing antibodies. Our results help further the understanding of protective mechanisms induced by the HEV vaccine. Furthermore, the tool box with 12 representative mAbs will be useful for studying the HEV infection process. PMID:26085097

  2. Analýza firemních kultur Baťa, Google a Toyota a porovnání postojů zaměstnanců v ČR v roce 2011

    OpenAIRE

    Ježková, Kateřina

    2011-01-01

    Bachelor thesis "An Analysis of Corporate Cultures Bata, Google and Toyota and Comparison of Attitudes of Employees in CR in 2011" briefly discusses the corporate culture in general- possible definitions, formation and change. Closer is discussed Schein's concept of corporate culture, especially his three level model. The study is also focused on corporate culture of Bata, Google and Toyota corporations, which was analyzed based on the available literature. A comparison of the concept of corp...

  3. Occurrence and prevalence of selected zoonotic agents: Echinococcus multilocularis, Trichinella spiralis and hepatitis E virus (HEV) in the population of Polish hunters--results of the study conducted in 2010-2012.

    Science.gov (United States)

    Sadkowska-Todys, Małgorzata; Baumann-Popczyk, Anna; Wnukowska, Natalia; Popczyk, Bartłomiej; Kucharczyk, Bożena; Gołąb, Elżbieta

    2015-01-01

    In Poland the development of the knowledge concerning zoonotic pathogens, of which free-living animals are the reservoir of is gaining in importance both in epidemiological aspect as well as in the context of prevention for improving public health. Dietary habits such as the consumption of forest undergrowth products and wild game meat, and the way of those products being prepared (in the process of barbequing) pose a risk factors of infection with the foodborne pathogens such as Echinococcus multilocularis, Trichinella spp., and HEV. The aim of this study is to estimate the prevalence of infections caused by Trichinella spp., Echinococcus multilocularis, and HEV in the population of Polish hunters, describing their geographical distribution in Poland, and to try to define basic factors, which may contribute to their occurrence. In 2010-2012 a cross-sectional study was carried out among Polish hunters. A blood samples were collected as well as a survey of 1027 participants recruited in the 16 provinces was also carried out. Serological tests were performed for the presence of specific antibodies against Echinococcus multilocularis, Trichinella spp. and HEV using commercial or "in home" ELISA tests. In case of positive result for Echinococcus, an Em2plus ELISA or/and western blot test were carried out, and for positive results for IgM for HEV a recomLine HEV IgM test was carried out. In the studied population a total number of 2 cases of Echinococcus multilocularis infection were found. Moreover in 47 (4,6%) participants presence of antibodies against Trichinella spp. were found, including 17 positive and 30 borderline results. In 206 persons (25%) IgG anti-HEV antibodies were found (by ELISA test). Geographical diversity in prevalence of both, the Trichinella spp. and HEV cases was observed. The study confirmed presence of zoonotic infections such as Echinococcus multilocularis, Trichinella spp., and hepatitis E (HEV) among Polish hunters. In the case of

  4. Redes de producción global y aprendizaje local para la competitividad en el sector automotriz: los casos de Ford-Hermosillo y Toyota-Tijuana

    Directory of Open Access Journals (Sweden)

    Óscar Contreras

    2016-03-01

    Full Text Available Este trabajo tiene tres objetivos: a mostrar las características de la nueva organización de producción en Ford Hermosillo y Toyota Tijuana; b analizar las consecuencias de incorporar compañías locales en la cadena de proveedores, y c analizar los mecanismos de transferencia de conocimiento de manufactura y capacidades gerenciales de las firmas líderes hacia las empresas locales. Los datos utilizados para el análisis en el caso de Ford provienen de un estudio reciente coordinado por óscar Contreras, basado en una encuesta con proveedores de Ford-Hermosillo, y en entrevistas con gerentes de empresas proveedoras de primera y segunda línea. En el caso de Tijuana, el análisis se basa en entrevistas realizadas con Toyota en el periodo 2003-2005, y con proveedores en 2006.

  5. Utilização de Bloquinhos de Montagem LEGO® para o Ensino dos Conceitos do Sistema Toyota de Produção

    Directory of Open Access Journals (Sweden)

    Alexandre Pinho

    2005-07-01

    Full Text Available Este artigo mostra como é possível facilitar  o aprendizado dos conceitos sobre o Sistema Toyota de Produção. É utilizada uma dinâmica de ensino através de bloquinhos de montagem LEGO® batizada de MIB – Montagem Interativa de Bloquinhos. Esta dinâmica além de abordar os principais conceitos sobre o Sistema de Toyota de Produção, também utiliza os conceitos sobre Just-in-time (JIT, tempo de setup, metodologia  5S e nivelamento de produção (Heijunka. O artigo descreve as quatro rodadas utilizadas na dinâmica MIB e como os conceitos descritos anteriormente são transmitidos aos alunos.

  6. Analisis SWOT Sebagai Faktor Penyusunan Strategi Manajemen Dalam Peningkatan Penjualan Mobil PT. Astra International TBK (Toyota Sales Operation) Cabang Medan Amplas

    OpenAIRE

    Lubis, Muhammad Arman

    2013-01-01

    Formulation of the problem described in this research is the strategies what is being done to improve sales management, how the role of the management strategies implemented in the increase of sales, what is the relationship between management strategy with the company's plans in the future, as well as what products the strengths and weaknesses as well as the products that have the opportunities and threats in PT Astra International Tbk (Toyota Sales Operation) Branch Medan Amplas. The purpos...

  7. Pengaruh Brand Image dan Kepercayaan Merek terhadap Minat Beli Konsumen pada Produk Mobil Toyota Etios Valco (Studi pada PT. Agung Automall Pekanbaru)

    OpenAIRE

    ", Antoni; Herianto, Meyzi

    2017-01-01

    In the higher level of competition, companies must be able to face competitors offering similar products. Competition between brands of each product in the vehicle will be more sharply captured the interest and attention of consumers. Realizing that the company PT. Agung Automall have prepared themselves by offering after-sales services that include maintenance and repair and supply of spare parts for the Toyota customer partners.This study aims to identify and analyze the brand image and bra...

  8. Navy Additive Manufacturing: Adding Parts, Subtracting Steps

    Science.gov (United States)

    2015-06-01

    consumers shifted buying preferences to vehicles that had higher gas mileage. Figure 13 depicts declining sales for GM, Ford, and Chrysler from 2004... Toyota leads the most costly recall in history when they recalled close to 9 million vehicles for models between 2004–2010 (Avalon, Camry, Corolla, Matrix...cases of runaway vehicles, half resulted in at least one death; thus, “ Toyota issued two separate recalls in 2009 and 2010 to ‘reconfigure’ the

  9. Applying the Lean principles of the Toyota Production System to reduce wait times in the emergency department.

    Science.gov (United States)

    Ng, David; Vail, Gord; Thomas, Sophia; Schmidt, Nicki

    2010-01-01

    In recognition of patient wait times, and deteriorating patient and staff satisfaction, we set out to improve these measures in our emergency department (ED) without adding any new funding or beds. In 2005 all staff in the ED at Hôtel-Dieu Grace Hospital began a transformation, employing Toyota Lean manufacturing principles to improve ED wait times and quality of care. Lean techniques such as value-stream mapping, just-in-time delivery techniques, workplace organization, reduction of systemic wastes, use of the worker as the source of quality improvement and ongoing refinement of our process steps formed the basis of our project. Our ED has achieved major improvements in departmental flow without adding any additional ED or inpatient beds. The mean registration to physician time has decreased from 111 minutes to 78 minutes. The number of patients who left without being seen has decreased from 7.1% to 4.3%. The length of stay (LOS) for discharged patients has decreased from a mean of 3.6 to 2.8 hours, with the largest decrease seen in our patients triaged at levels 4 or 5 using the Canadian Emergency Department Triage and Acuity Scale. We noted an improvement in ED patient satisfaction scores following the implementation of Lean principles. Lean manufacturing principles can improve the flow of patients through the ED, resulting in greater patient satisfaction along with reduced time spent by the patient in the ED.

  10. Analisis Karakteristik Traksi Serta Redesign Rasio Transmisi Mobil Toyota Fortuner 4.0 V6 Sr (At 4x4

    Directory of Open Access Journals (Sweden)

    Nico Yudha Wardana

    2017-01-01

    Full Text Available Produksi mobil Indonesia tahun 2014 mengalami peningkatan sebanyak 1,29 juta unit, meningkat 7,5 persen dari tahun sebelumnya dan terus mengalami peningkatan pada tahun 2015 sebesar 2 juta unit (Kemenprin, 1/16. Tingginya penjualan mobil tersebut tidak diiringi dengan upaya produsen untuk mencerdaskan konsumen mengenai performa mobil. Hal tersebut yang mendasari penulis untuk melakukan analisa karakteristik traksi pada mobil Toyota fortuner 4.0 V6 SR (4X4 AT. Dalam penelitian ini, telah dilakukan tiga tahapan pengujian. Tahapan pertama adalah melakukan pengujian dynotest pada mobil untuk mengetehaui efisiensi transmisi. Tahap kedua, dilakukan analisa perhitungan sehingga di dapatkan grafik karakteristik mobil pada kondisi standar. Selanjutnya tahap ketiga dilakukan evaluasi terhadap grafik karakteristik traksi mobil standar, dilanjutkan dengan proses redesign tingkat transmisi untuk mengoptimalkan kinerja mobil menggunakan metode progressi geometri. Dari penelitian ini diperoleh grafik karakteristik traksi mobil untuk kondisi rasio gigi standar serta hasil redesign dengan 5,6 dan 7 tingkat kecepatan. Setelah dilakukan analisa, ternyata distribusi traksi pada mobil kondisistandar tidak merata, terdapat loses yang cukup besar terutama pada 3 tingkatan gigi awal. Hasil redesign dengan menggunakan teori progressi geometry menunjukan distribusi traksi yang lebih baik dari kondisi standar. Loses traksi untuk perpindahan gigi pertama menuju tingkat gigi kedua yang awalnya pada kondisi standar sebesar 4.564 kN dapat diminimalisir sampai dengan 1 kN setelah dilakukan redesign dengan 7 tingkat kecepatan.

  11. A High-Power Wireless Charging System Development and Integration for a Toyota RAV4 Electric Vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Onar, Omer C [ORNL; Seiber, Larry Eugene [ORNL; White, Cliff P [ORNL; Chinthavali, Madhu Sudhan [ORNL; Campbell, Steven L [ORNL

    2016-01-01

    Several wireless charging methods are underdevelopment or available as an aftermarket option in the light-duty automotive market. However, there are not many studies detailing the vehicle integrations, particularly a complete vehicle integration with higher power levels. This paper presents the development, implementation, and vehicle integration of a high-power (>10 kW) wireless power transfer (WPT)-based electric vehicle (EV) charging system for a Toyota RAV4 vehicle. The power stages of the system are introduced with the design specifications and control systems including the active front-end rectifier with power factor correction (PFC), high frequency power inverter, high frequency isolation transformer, coupling coils, vehicle side full-bridge rectifier and filter, and the vehicle battery. The operating principles of the control, communications, and protection systems are also presented in addition to the alignment and the driver interface system. The physical limitations of the system are also defined that would prevent the system operating at higher levels. The experiments are carried out using the integrated vehicle and the results obtained to demonstrate the system performance including the stage-by-stage efficiencies with matched and interoperable primary and secondary coils.

  12. Magnetic Decoupling Design and Experimental Validation of a Radial-Radial Flux Compound-Structure Permanent-Magnet Synchronous Machine for HEVs

    Directory of Open Access Journals (Sweden)

    Zhiyi Song

    2012-10-01

    Full Text Available The radial-radial flux compound-structure permanent-magnet synchronous machine (CS-PMSM, integrated by two concentrically arranged permanent-magnet electric machines, is an electromagnetic power-splitting device for hybrid electric vehicles (HEVs. As the two electric machines share a rotor as structural and magnetic common part, their magnetic paths are coupled, leading to possible mutual magnetic-field interference and complex control. In this paper, a design method to ensure magnetic decoupling with minimum yoke thickness of the common rotor is investigated. A prototype machine is designed based on the proposed method, and the feasibility of magnetic decoupling and independent control is validated by experimental tests of mutual influence. The CS-PMSM is tested by a designed driving cycle, and functions to act as starter motor, generator and to help the internal combustion engine (ICE operate at optimum efficiency are validated.

  13. Takt-time: conceitos e contextualização dentro do Sistema Toyota de Produção Takt-time: concepts and context in Toyota Production System

    Directory of Open Access Journals (Sweden)

    Roberto dos Reis Alvarez

    2001-04-01

    Full Text Available O presente trabalho tem como preocupação central esclarecer, o máximo possível, o conceito de takt-time, na medida em que se pode observar um hiato na literatura que trata do tema em relação à compreensão das diferenças conceituais entre esse e as definições de tempo de ciclo e tempo padrão. Procura-se estabelecer uma conceituação rigorosa desses termos, tendo como referência básica os princípios gerais do Sistema Toyota de Produção (STP. Enfatiza-se a importância crucial da variável tempo para a gestão dos sistemas de produção, partindo-se da problemática da sincronização do fluxo dos materiais ao longo do tempo e do espaço no STP. Nesse contexto, ressalta-se a centralidade do takt-time na gestão da produção em diferentes aspectos do Sistema. Nuances relativas à flexibilidade também são destacadas. Os pontos conceituais que marcam a lógica da utilização do takt-time, a partir da ótica mais ampla da sincronização da produção, permitem identificar os limites de aplicação da sistemática. Finalmente, é analisada a relação da sistemática de gestão baseada na definição do takt-time com as lógicas da qualidade assegurada e da formação de recursos humanos.This text aims at clarifying, as much as possible, the concept of takt-time, considering that it is possible to perceive a gap in the literature in relation to the understanding of the conceptual differences between this and the definition of cycle time. An attempt to establish a rigorous conceptual framework for the understanding of the terms is made here, taking the principles of the Toyota Production System (TPS as a basic reference. Based on the problem of synchronizing materials flow along time and space in the TPS, the emphasis is put on the comprehension of time as a fundamental variable for production systems' management. In such a context, takt-time's central role in TPS' management scheme is highlighted. Aspects concerning the

  14. Analisis Pengaruh Parameter Operasional dan Penggunaan Stabilizer terhadap Perilaku Arah Belok Mobil Toyota Fortuner 4.0 V6 SR (AT 4X4

    Directory of Open Access Journals (Sweden)

    Deva Andriansyah

    2017-01-01

    Full Text Available Salah satu tipe mobil yang diminati oleh masyarakat Indonesia yaitu Toyota Fortuner yang termasuk dalam kelas mobil SUV (sport utility vehicle. Dalam pengoperasiannya mobil SUV harus mampu memberikan keamanan dan kenyamanan bagi pengendaranya. Salah satu faktor penunjang dari segi keamanan mobil ini yaitu perilaku arah beloknya. Dengan harga jual yang relatif tinggi di Indonesia, diharapkan mobil ini dapat memberikan perilaku arah belok yang baik. Terdapat dua tahapan dalam peneltian ini yaitu tahap analisis dan uji jalan pada radius belok tetap, 10 meter. Pada tahap analisis dilakukan perhitungan berdasarkan analisa slip, skid, dan guling untuk mengetahui perilaku arah belok mobil dengan variasi pada parameter operasionalnya yaitu: jumlah penumpang, kecepatan, sudut belok, kondisi permukaan jalan, dan tekanan ban. Selain itu, analisis pengaruh penggunaaan stabilizer terhadap perilaku arah belok mobil juga dilakukan. Uji jalan dilakukan untuk mengetahui Koefisien Understeer (KUS dari mobil tersebut pada jalan aspal dan tanah dengan kondisi mobil tanpa dan menggunakan stabilizer. Hasil yang didapatkan dari uji jalan akan dibandingkan dengan hasil dari analisis perhitungan. Hasil penelitian ini menunjukkan bahwa mobil Toyota Fortuner mengalami kondisi belok paling baik ketika dinaiki oleh 2 orang penumpang dengan tekanan ban sebesar 35 Psi dan melintas pada jalan aspal karena kendaraan lebih sedikit mengalami oversteer dan memiliki (KUS positif terkecil serta tidak mudah mengalami skid. Penggunaan stabilizer pada mobil Toyota Fortuner tidak berpengaruh terhadap perilaku arah beloknya karena KUS yang dihasilkan pada uji jalan nilainya hampir sama yaitu 1,8045 dan 1,8115 pada jalan aspal serta 2,151 dan 2,1641 pada jalan tanah. Namun, penggunaan stabilizer bermanfaat untuk memperkecil sudut guling ketika mobil berbelok.

  15. 丰田生产方式在载货车车身生产中的应用%Application of Toyota Production System in Truck Body Production

    Institute of Scientific and Technical Information of China (English)

    崔颖; 韩基栋

    2005-01-01

    丰田生产方式(Toyota Production System)简称TPS,即精益生产方式,在提高和稳定产品质量,提高效益方面卓有奇效,它是以消除一切浪费为目标,为企业谋取经济效益。对中国企业的现代化管理具有参考和借鉴作用。

  16. 谈一汽-丰田体系的涂装线管理%Discussions on Painting Line Management of FAW-Toyota System

    Institute of Scientific and Technical Information of China (English)

    宫金宝; 李树阳; 荆宏

    2006-01-01

    丰田汽车公司在自身的发展过程中,创造了一整套独特的管理经验。一汽-丰田体系涂装线正是以这种“丰田生产方式”(Toyota Production System,简称TPS)作为主要的生产管理理念。下面仅就一汽-丰田体系涂装线管理的几种典型思想理念进行简要介绍。

  17. 欧洲新车零部件配套目录续(十):新款Toyota Yaris

    Institute of Scientific and Technical Information of China (English)

    漓沙

    2005-01-01

    第二代Toyota Yaris的角模块由Auto Chassis International(ACI)公司提供,这是雪诺旗下有6年历史的全资子公司。这也是丰田首次在欧洲外购底盘系统模块。丰田汽车负责欧洲工程和生产的执行副总裁Kazuhiko Miyadera说.在过去3年里,丰田致力于增加其在欧洲的采购置。

  18. 78 FR 41016 - Preliminary Theft Data; Motor Vehicle Theft Prevention Standard

    Science.gov (United States)

    2013-07-09

    ... MOTORS..... CHEVROLET CAMARO.. 196 97,518 2.0099 21 MERCEDES-BENZ...... S-CLASS 19 9,652 1.9685 22 TOYOTA... 62,836 1.6074 32 TOYOTA CAMRY/SOLARA...... 781 486,288 1.6060 33 FORD MOTOR CO...... TAURUS 118 76,821 1.5360 34 TOYOTA YARIS 38 24,850 1.5292 35 AUDI AUDI A3 10 6,734 1.4850 36 CHRYSLER 300 42 28,373...

  19. Toyota Center (Architecture Hightech)

    OpenAIRE

    Harsono, Syafiz

    2011-01-01

    Indonesia merupakan sebuah Negara yang sedang berkembang. Setelah krisis ekonomi pada tahun 1998, Indonesia berjuang keluar dari krisis ekonomi. Di era globalisasi ini kebutuhan masyarakat semakin meningkat salah satunya merupakan kebutuhan akan sarana transportasi. Kebutuhan masyarakat akan sarana transportasi sangat besar,hal ini terbukti dari data yang didapatkan dari hasil penjualan kendaraan bermotor pada tahun 2003, 2004 dan 2005 mengalami peningkatan. Hal ini mengindikasikan walaupun ...

  20. Productieprocessen - Toyota Production System

    NARCIS (Netherlands)

    R, Akkerman; L. Buning; H.J. Kort

    2011-01-01

    Het hanteren en beheersen van specifieke productieprocessen heeft een positief effect op de efficiëntie waarmee bedrijven hun productie voeren en daarmee ook op hun concurrentiepositie. Dit geldt tevens voor de automobielindustrie en hun toeleveranciers. In diverse onderzoeken rondom het toepassen

  1. The impact of system level factors on treatment timeliness: utilizing the Toyota Production System to implement direct intake scheduling in a semi-rural community mental health clinic.

    Science.gov (United States)

    Weaver, Addie; Greeno, Catherine G; Goughler, Donald H; Yarzebinski, Kathleen; Zimmerman, Tina; Anderson, Carol

    2013-07-01

    This study examined the effect of using the Toyota Production System (TPS) to change intake procedures on treatment timeliness within a semi-rural community mental health clinic. One hundred randomly selected cases opened the year before the change and 100 randomly selected cases opened the year after the change were reviewed. An analysis of covariance demonstrated that changing intake procedures significantly decreased the number of days consumers waited for appointments (F(1,160) = 4.9; p = .03) from an average of 11 to 8 days. The pattern of difference on treatment timeliness was significantly different between adult and child programs (F(1,160) = 4.2; p = .04), with children waiting an average of 4 days longer than adults for appointments. Findings suggest that small system level changes may elicit important changes and that TPS offers a valuable model to improve processes within community mental health settings. Results also indicate that different factors drive adult and children's treatment timeliness.

  2. Effect of pregnancy on anti-HEV antibody titres, plasma cytokines and the corresponding gene expression levels in the PBMCs of patients presenting with self-recovering clinical and subclinical hepatitis E.

    Directory of Open Access Journals (Sweden)

    Ashwini Y Ramdasi

    Full Text Available High mortality in pregnant women (PR is a characteristic of hepatitis E in developing countries. To understand the pathogenesis of HEV infection in self-limiting disease during pregnancy, we compared clinical (PR-patients and subclinical-HEV-infections in pregnant women in the first (SC-PR-1 and later (2nd and 3rd, SC-PR-2+3 trimesters with the respective healthy controls and acute non-PR patients. The SC-PR-2+3 exhibited lower ALT, bilirubin levels, anti-HEV-IgM/IgG titres than the acute-PR/non-PR-patients (p<0.05-0.0001. IFNγ/IL4ratios indicated Th2/Th1 bias in non-PR and PR-patients respectively. Raised levels of 10/20 plasma cytokines in the non-PR-patients reflect predominant inflammatory response, unaltered- IFNγ/reduced-IFNα responses and a robust chemokine secretion. On contrary, the acute-PR-patients exhibited drastic reduction in majority of the cytokines relative to in the non-PR-patients. Importantly, diminished or unaltered response was noted in the acute-PR-group when compared to the corresponding controls. The only exception was sIL2RA, increasing in both patient categories. Of the 14 genes evaluated, the expression of IFNγ/IL10/IL1A/IL7/CCL2/CCL3/CXCL8/CXCL10 was higher in the non-PR patients. Of these, the expression of IFNγ/IL10/IL1A/CCL2/CCL3/CXCL8 and, additionally, IL2/IL6/TNF genes was higher in the clinical-PRs. Almost identical pattern was noted in the control-PR-2+3 category indicating no influence of HEV infection. Comparison of patient-categories identified significant elevation of IFNγ(P<0.001, CCL2(p<0.01, CXCL8(P<0.05, IL1B(p<0.05 and IL10(P<0.0001 and decrease in CXCL10(<0.05 in the PR-patients. The results suggest antibody-dependent disease severity and impaired immune response in the PR patients. Higher expression of cytokine-genes in the PBMCs did not correlate with the plasma-cytokine levels in the PR-patients.

  3. Elaboración de las políticas y procesos de control interno para mitigar los riesgos legales-tibutarios de Toyota del Ecuador S.A.

    OpenAIRE

    Flores Andrade, Wilson Roberto

    2015-01-01

    This dissertation seeks to establish policies and internal control procedures governing the activities of Toyota del Ecuador S.A. in order to mitigate potential legal-tax risks. The legislation that applies to the Ecuadorian automotive industry, and tax theory are described in Chapter 1. They also take into account basic concepts and several systems of internal control, choosing as the basis for this paper the COSO II model. Chapter 2 begins by describing the international environment o...

  4. EL KAIZEN COMO UN SISTEMA ACTUAL DE GESTIÓN PERSONAL PARA EL ÉXITO ORGANIZACIONAL EN LA EMPRESA ENSAMBLADORA TOYOTA

    Directory of Open Access Journals (Sweden)

    Edgar Chirinos

    2010-07-01

    Full Text Available La investigación propone estrategias kaizen para la mejora de estándares tecnológicos, gerenciales y operacionales en la empresa Toyota ubicada en Cumaná, estado Sucre. Es una investigación no experimental, de campo de carácter descriptivo. El análisis se enmarcó dentro de la estadística descriptiva, así como las proyecciones de la población en estudio, los encuestados revelaron tendencias y comportamiento de las opiniones emitidas en relación a las metodologías para diagnosticar las necesidades de aplicaciones de los ciclos PDCA/SDCA, como vehículo político para el mantenimiento y mejoramiento de los estándares empleados. Se concluye que es imprescindible efectuar una revisión de los indicadores que se encuentran en el nivel Requieren Atención, hasta que se logre indicadores definitivamente en otra escala positiva.

  5. Analysis on TOYOTA's Production Mode TPS%解读丰田生产模式(TPS)--走近丰田叉车系列报道之三

    Institute of Scientific and Technical Information of China (English)

    陈方建

    2004-01-01

    @@ 丰田生产模式(Toyota Production System,TPS)对国内读者来说并不陌生,它产生于日本丰田公司,是"为实现企业对员工、社会和产品负责的目的,以彻底杜绝浪费的思想为目标,在连续改善的基础上,采用准时化与自动化方式与方法,追求制造产品合理性的一种生产方式".通过此次赴日对丰田叉车日本总部的参观考察,笔者对这一在全世界广受瞩目的生产模式有了更进一步的了解与认识,在此愿提出来与大家共享.

  6. ANALISIS IDENTIFIKASI MASALAH DENGAN MENGGUNAKAN METODE FAILURE MODE AND EFFECT ANALYSIS (FMEA DAN RISK PRIORITY NUMBER (RPN PADA SUB ASSEMBLY LINE (Studi Kasus : PT. Toyota Motor Manufacturing Indonesia

    Directory of Open Access Journals (Sweden)

    Nia Budi Puspitasari

    2017-07-01

    Abstract The failure rate is a problem that has always attempted to be minimized by a company in order to improve the quality of products, and also were conducted by oleh Toyota Motor Manufacturing Indonesia (PT. TMMIN which is consistent in producting a quality product.  Knowing that in 2016 there is a defect GAP at 50 ppm, PT. TMMIN needs to identify the failures that occur in their company. FMEA is a method to identify and analyze the failure modes in detail that can able to know the cause and impact of each failures, so we get the proper repairment. FMEA that is used in PT. TMMIN case study indicate various modes of failure in assembly-line, then known the alternatives to repair for any prioritize failures. The priorities failures can be seen in the Risk Priority Number (RPN. Based on the RPN resulting, we can obtain the priority failures in  assembly-line of PT. TMMIN that are about the part installation errors, failures due to foreign objects in the part, and the failure of the piston assembly errors.

  7. The Impact of System Level Factors on Treatment Timeliness: Utilizing the Toyota Production System to Implement Direct Intake Scheduling in a Semi-Rural Community Mental Health Clinic

    Science.gov (United States)

    Weaver, A.; Greeno, C.G.; Goughler, D.H.; Yarzebinski, K.; Zimmerman, T.; Anderson, C.

    2013-01-01

    This study examined the effect of using the Toyota Production System (TPS) to change intake procedures on treatment timeliness within a semi-rural community mental health clinic. One hundred randomly selected cases opened the year before the change and one hundred randomly selected cases opened the year after the change were reviewed. An analysis of covariance (ANCOVA) demonstrated that changing intake procedures significantly decreased the number of days consumers waited for appointments (F(1,160)=4.9; p=.03) from an average of 11 days to 8 days. The pattern of difference on treatment timeliness was significantly different between adult and child programs (F(1,160)=4.2; p=.04), with children waiting an average of 4 days longer than adults for appointments. Findings suggest that small system level changes may elicit important changes and that TPS offers a valuable model to improve processes within community mental health settings. Results also indicate that different factors drive adult and children’s treatment timeliness. PMID:23576137

  8. Report on a project to support promotion of forming an environmentally friendly energy community. Survey on an environmentally friendly community business by means of high-efficiency wastes power generation system in the Toyota-Kamo wide area; Kankyo chowagata energy community keisei sokushin hojo jigyo chosa hokokusho. Toyota Kamo koikiken kokoritsu haikibutsu hatsuden kankyo chowagata energy community jigyo chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Taking the Toyota-Kamo wide area as the object, wastes power generation is positioned over the society system as worked on by administrations and operators integrally to incinerate mixedly those incineratable materials such as plastics among general and industrial combustible wastes for high-efficiency generation of power, which is supplied to electric utility operators as surplus power. Discussions were given on the business feasibility and the effectiveness as a society system. In this area, the mixed model B plan (dealing with general wastes plus industrial wastes) was evaluated as an effective plan as the society system. This is because the plan has effect to incinerate, melt and generate power from industrial wastes which have been used for land-fill, effect of improving the power generation efficiency, and effectiveness of mixed treatment with general wastes. The plan A in which general wastes are made into RDF, then incinerated mixedly with industrial wastes for power generation was evaluated to have high reliability potential of power supply and to be an effective plan as a society system, if effect can be expected to reduce transportation energy as a result of making the system large enough and turning wastes into RDF. (NEDO)

  9. Discussão teórica sobre o conceito de perdas do Sistema Toyota de Produção: inserindo a lógica do ganho da Teoria das Restrições Theoretical discussion of the concept of wastes in the Toyota Production System: introducing the throughput logic of the Theory of Constraints

    Directory of Open Access Journals (Sweden)

    Isaac Pergher

    2011-01-01

    Full Text Available Este estudo apresenta uma reflexão teórica a respeito dos possíveis impactos nos indicadores da Teoria das Restrições (TOC provocados pelas Sete Perdas abordadas no Sistema Toyota de Produção (STP e por um tipo de perda não relatada neste contexto. Trata-se da 'Perda por má definição do mix de produtos' influenciada pelo uso de métodos inadequados para formular o mix de produtos. Desta forma é construído um neologismo conceitual identificado como as 'Pergas' para demostrar as perdas de Ganho global (TOC, derivadas desta prática. A necessidade de combater as perdas nos processos deve-se a não agregação de valor ao produto, bem como a geração de custos, motivando, em algumas situações, o compromentimento à competitividade da organização. Em sentido similar, o combate às Pergas proporciona um incremento nos índices monitorados pelos indicadores Globais da TOC por meio da constiuição de um mix de produtos que contribua com a meta da empresa. Um referencial estrutural é desenvolvido relacionando as Sete Perdas abordadas no STP e os indicadores da TOC, o qual fornecerá subsídios para fundamentar as relações impactantes e possibilitará a proposição de ações de melhoria tendo por objetivo minimizar os impactos apresentados.This study presents a theoretical reflection about the possible impacts on of the Theory of Constraints (TOC indicators caused by the Seven Wastes in the Toyota Production System (TPS and a type of waste which is not included in that context. It refers to the 'waste due to unsatisfactory definition of product mix' influenced by the use of inappropriate methods to formulate the product mix. Therefore, a conceptual neologism is introduced, identified as the "Pergas" to demonstrate the overall gain waste derived from this practice. The need to reduce process waste is due to the fact that no value is added to the product and the cost increase putting at risk, in some situations, the organizational

  10. 76 FR 35271 - Toyota Motor Corporation, Inc., on Behalf of Toyota Corporation, and Toyota Manufacturing...

    Science.gov (United States)

    2011-06-16

    ..., symbols or pictograms are used, their meaning is explained to the consumer in writing, such as in the... vertical transverse and horizontal longitudinal planes intersecting at the horizontal centerline of each... longitudinal plane that passes through the center of the bar ( 25 mm); (4) The circle may be on a tag...

  11. 77 FR 24265 - Toyota Motor Corporation, Inc., on Behalf of Toyota Corporation, and Toyota Manufacturing...

    Science.gov (United States)

    2012-04-23

    ..., symbols or pictograms are used, their meaning is explained to the consumer in writing, such as in the... and horizontal longitudinal planes intersecting at the horizontal centerline of each lower anchorage, as illustrated in Figure 22. The center of the circle must be in the vertical longitudinal plane that...

  12. heväärtusliku vallasasja süstemaatiline vargus KarS § 199 lõike 2 punkti 9 tähenduses. Tartu Ringkonnakohtu kriminaalkolleegiumi määrus kriminaalasjas 1-11-11324 (Riigikohtu kriminaalkolleegiumi otsuses asjas 3-1-1-87-07 väljendatud seisu

    Index Scriptorium Estoniae

    Randma, Paavo, 1977-

    2013-01-01

    Riigikohus leidis lahendis 3-1-1-87-07, et süstemaatilisuse jaatamiseks on vaja isiku poolt vähemalt kolme varguse toimepanemist. Ringkonnakohus asus lahendis 1-11-11324 seisukohale, et varguste toimepanemisest kui inimese elustiilist saab väheväärtuslike vallasasjade varastamise korral rääkida vaid juhul, kui need pannakse toime teatud kindla ajavahemiku vältel

  13. New high expansion ratio gasoline engine for the TOYOTA hybrid system. Improving engine efficiency with high expansion ratio cycle; Hybrid system yo kobochohi gasoline engine. Kobochohi cycle ni yoru engine no kokoritsuka

    Energy Technology Data Exchange (ETDEWEB)

    Hirose, K; Takaoka, T; Ueda, T; Kobayashi, Y [Toyota Motor Corp., Aichi (Japan)

    1997-10-01

    50% reduction of CO2 and fuel consumption have been achieved with the newly developed gasoline engine for the Toyota Hybrid System. This is achieved due to the combination of electric motors and the internal combustion engine which is optimized in the size, swept volume and heat cycle. By delaying the intake valve close timing a high expansion ratio (13.5:1) cycle has been realized. Electricmotor assist enable to cut the maximum engine speed, and friction loss. A best fuel consumption figure better than 230 g/kWh has been achieved. Elimination of lightload firing, motor assisted quick start and improvement of catalyst warm up makes to achieve the clean emission level such as 1/10 of Japanese `78 regulation limit. 10 refs., 16 figs., 1 tab.

  14. Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes.

    Science.gov (United States)

    Karisola, Piia; Mikkola, Jari; Kalkkinen, Nisse; Airenne, Kari J; Laitinen, Olli H; Repo, Susanna; Pentikäinen, Olli T; Reunala, Timo; Turjanmaa, Kristiina; Johnson, Mark S; Palosuo, Timo; Kulomaa, Markku S; Alenius, Harri

    2004-02-15

    Recently we have established that IgE Abs bind to conformational epitopes in the N- and C-terminal regions of the major natural rubber latex allergen, hevein (Hev b 6.02). To identify the critical amino acid residues that interact with IgE, the hevein sequence was scanned by using site-specific mutations. Twenty-nine hevein mutants were designed and produced by a baculovirus expression system in insect cells and tested by IgE inhibition-ELISA using sera from 26 latex allergic patients. Six potential IgE-interacting residues of hevein (Arg(5), Lys(10), Glu(29), Tyr(30), His(35), and Gln(38)) were identified and characterized further in detail. Based on these six residues, two triple mutants (Hdelta3A, Hdelta3B) and hevein mutant where all six residues were mutated (Hdelta6), were designed, modeled, and produced. Structural and functional properties of these combinatory mutants were compared experimentally and in silico with those of recombinant hevein. The IgE-binding affinity of the mutants decreased by three to five orders of magnitude as compared with that of recombinant hevein. Skin prick test reactivity of the triple mutant HDelta3A was drastically reduced and that of the six-residue mutant Hdelta6 was completely abolished in all patients examined in this study. The approach presented in this paper offers tools for identification and modification of amino acid residues on conformational epitopes of allergens that interact with IgE. Hevein with a highly reduced ability to bind IgE should provide a valuable candidate molecule for immunotherapy of latex allergy and is anticipated to have a low risk of systemic side effects.

  15. Crystallization and Identification of the Glycosylated Moieties of Two Isoforms of the Main Allergen Hev b 2 and Preliminary X-ray Analysis of Two Polymorphs of Isoform ll

    Energy Technology Data Exchange (ETDEWEB)

    Fuentes-Silva,D.; Mendoza-Hernandez, G.; Stojanoff, V.; Palomares, L.; Zenteno, E.; Torres-Larios, A.; Rodriguez-Romero, A.

    2007-01-01

    Latex from Hevea brasiliensis contains several allergenic proteins that are involved in type I allergy. One of them is Hev b 2, which is a {beta}-1,3-glucanase enzyme that exists in different isoforms with variable glycosylation content. Two glucanase isoforms were isolated from trees of the GV-42 clone by gel filtration, affinity and ion-exchange chromatography. Isoform I had a carbohydrate content of about 20%, with N-linked N-acetyl-glucosamine, N-acetyl-galactosamine, fucose and galactose residues as the main sugars, while isoform II showed 6% carbohydrate content consisting of N-acetyl-glucosamine, fucose, mannose and xylose. Both isoforms were crystallized by the hanging-drop vapor-diffusion method. Isoform I crystals were grown using 0.2 M trisodium citrate dihydrate, 0.1 M Na HEPES pH 7.5 and 20%(v/v) 2-propanol, but these crystals were not appropriate for data collection. Isoform II crystals were obtained under two conditions and X-ray diffraction data were collected from both. In the first condition (0.2 M trisodium citrate, 0.1 M sodium cacodylate pH 6.5, 30% 2-propanol), crystals belonging to the tetragonal space group P4{sub 1} with unit-cell parameters a = b = 150.17, c = 77.41 {angstrom} were obtained. In the second condition [0.2 M ammonium acetate, 0.1 M trisodium citrate dihydrate pH 5.6, 30%(w/v) polyethylene glycol 4000] the isoform II crystals belonged to the monoclinic space group P2{sub 1}, with unit-cell parameters a = 85.08, b = 89.67, c = 101.80 {angstrom}, {beta}= 113.6{sup o}. Preliminary analysis suggests that there are four molecules of isoform II in both asymmetric units.

  16. Crystallization and identification of the glycosylated moieties of two isoforms of the main allergen Hev b 2 and preliminary X-ray analysis of two polymorphs of isoform II

    Energy Technology Data Exchange (ETDEWEB)

    Fuentes-Silva, D. [Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Cuidad Universitaria, Coyoacán, México, DF 04510 (Mexico); Mendoza-Hernández, G. [Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Cuidad Universitaria, Coyoacán, México, DF 04510 (Mexico); Stojanoff, V. [Brookhaven National Laboratory, National Synchrotron Light Source, Upton, NY (United States); Palomares, L. A. [Instituto de Biotecnología, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Cuidad Universitaria, Coyoacán, México, DF 04510 (Mexico); Zenteno, E. [Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Cuidad Universitaria, Coyoacán, México, DF 04510 (Mexico); Torres-Larios, A. [Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Cuidad Universitaria, Coyoacán, México, DF 04510 (Mexico); Rodríguez-Romero, A., E-mail: adela@servidor.unam.mx [Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Cuidad Universitaria, Coyoacán, México, DF 04510 (Mexico)

    2007-09-01

    Crystallization of important glycoenzymes involved in IgE-mediated latex allergy. Latex from Hevea brasiliensis contains several allergenic proteins that are involved in type I allergy. One of them is Hev b 2, which is a β-1,3-glucanase enzyme that exists in different isoforms with variable glycosylation content. Two glucanase isoforms were isolated from trees of the GV-42 clone by gel filtration, affinity and ion-exchange chromatography. Isoform I had a carbohydrate content of about 20%, with N-linked N-acetyl-glucosamine, N-acetyl-galactosamine, fucose and galactose residues as the main sugars, while isoform II showed 6% carbohydrate content constisting of N-acetyl-glucosamine, fucose, mannose and xylose. Both isoforms were crystallized by the hanging-drop vapour-diffusion method. Isoform I crystals were grown using 0.2 M trisodium citrate dihydrate, 0.1 M Na HEPES pH 7.5 and 20%(v/v) 2-propanol, but these crystals were not appropriate for data collection. Isoform II crystals were obtained under two conditions and X-ray diffraction data were collected from both. In the first condition (0.2 M trisodium citrate, 0.1 M sodium cacodylate pH 6.5, 30% 2-propanol), crystals belonging to the tetragonal space group P4{sub 1} with unit-cell parameters a = b = 150.17, c = 77.41 Å were obtained. In the second condition [0.2 M ammonium acetate, 0.1 M trisodium citrate dihydrate pH 5.6, 30%(w/v) polyethylene glycol 4000] the isoform II crystals belonged to the monoclinic space group P2{sub 1}, with unit-cell parameters a = 85.08, b = 89.67, c = 101.80 Å, β = 113.6°. Preliminary analysis suggests that there are four molecules of isoform II in both asymmetric units.

  17. Crystallization and identification of the glycosylated moieties of two isoforms of the main allergen Hev b 2 and preliminary X-ray analysis of two polymorphs of isoform II

    International Nuclear Information System (INIS)

    Fuentes-Silva, D.; Mendoza-Hernández, G.; Stojanoff, V.; Palomares, L. A.; Zenteno, E.; Torres-Larios, A.; Rodríguez-Romero, A.

    2007-01-01

    Crystallization of important glycoenzymes involved in IgE-mediated latex allergy. Latex from Hevea brasiliensis contains several allergenic proteins that are involved in type I allergy. One of them is Hev b 2, which is a β-1,3-glucanase enzyme that exists in different isoforms with variable glycosylation content. Two glucanase isoforms were isolated from trees of the GV-42 clone by gel filtration, affinity and ion-exchange chromatography. Isoform I had a carbohydrate content of about 20%, with N-linked N-acetyl-glucosamine, N-acetyl-galactosamine, fucose and galactose residues as the main sugars, while isoform II showed 6% carbohydrate content constisting of N-acetyl-glucosamine, fucose, mannose and xylose. Both isoforms were crystallized by the hanging-drop vapour-diffusion method. Isoform I crystals were grown using 0.2 M trisodium citrate dihydrate, 0.1 M Na HEPES pH 7.5 and 20%(v/v) 2-propanol, but these crystals were not appropriate for data collection. Isoform II crystals were obtained under two conditions and X-ray diffraction data were collected from both. In the first condition (0.2 M trisodium citrate, 0.1 M sodium cacodylate pH 6.5, 30% 2-propanol), crystals belonging to the tetragonal space group P4 1 with unit-cell parameters a = b = 150.17, c = 77.41 Å were obtained. In the second condition [0.2 M ammonium acetate, 0.1 M trisodium citrate dihydrate pH 5.6, 30%(w/v) polyethylene glycol 4000] the isoform II crystals belonged to the monoclinic space group P2 1 , with unit-cell parameters a = 85.08, b = 89.67, c = 101.80 Å, β = 113.6°. Preliminary analysis suggests that there are four molecules of isoform II in both asymmetric units

  18. Seroprevalence for hepatitis E virus (HEV infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná , Brazil Soroprevalência da infecção pelo virus da hepatite E (VHE em candidatos a doadores de sangue voluntários do Hemocentro Regional de Londrina, Londrina, Estado do Paraná, Brasil

    Directory of Open Access Journals (Sweden)

    André Luiz Bortoliero

    2006-04-01

    Full Text Available A cross-sectional study was carried out among 996 volunteer blood donors enrolled from May 1999 to December 1999 to determine the seroprevalence of hepatitis E virus (HEV infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná, Brazil, and to evaluate whether the rate of seroprevalence of IgG anti-HEV antibodies is associated with sociodemographic variables and with seropositivity for hepatitis A virus (HAV infection. All participants answered the questionnaire regarding the sociodemographic characterisitcs. Serum samples were tested for IgG antibodies to HEV (anti-HEV by an enzyme linked immunoassay (ELISA. All serum samples positive for anti-HEV IgG and 237 serum samples negative for anti-HEV were also assayed for IgG anti-HAV antibodies by ELISA. Anti-HEV IgG was confirmed in 23/996 samples, resulting in a seroprevalence of 2.3% for HEV infection, similar to previous results obtained in developed countries. No significant association was found between the presence of anti-HEV IgG antibodies and the sociodemographic variables including gender, age, educational level, rural or urban areas, source of water, and sewer system (p > 0.05. Also, no association with seropositivity for anti-HAV IgG antibodies was observed (p > 0.05. Although this study revealed a low seroprevalence of HEV infection in the population evaluated, the results showed that this virus is circulating among the population from Londrina, South Brazil, and point out the need of further studies to define the clinical and epidemiological importance of HEV infection and to identify additional risk factors involved in the epidemiology and pathogenesis of this infection in this population.Os objetivos do estudo foram determinar a soroprevalência da infecção pelo vírus da hepatite E (VHE em candidatos a doadores de sangue voluntários do Hemocentro Regional de Londrina, Paraná, e avaliar se essa soroprevalência está associada com vari

  19. Overview of battery technology for HEV

    NARCIS (Netherlands)

    Smets, S.; Debal, P.; Conte, V.; Alaküla, M.; Santini, D.; Duvall, M.; Winkel, R.; Badin, F.

    2006-01-01

    Several electric energy storage systems exist with different principles and characteristics. On the other hand, there are also various hybrid electric vehicles with specific requirements. This paper gives an overview of the advantages/disadvantages and practical aspects of battery technologies and

  20. 浅析丰田装载标准作业在我国整车物流的应用%Toyota is Analysed Load Standard Work in the Application of Vehicle Logistics in our Country

    Institute of Scientific and Technical Information of China (English)

    罗家权

    2014-01-01

    Handling operation is an important part of automobile logistics,and on the transport vehicle logistics business has an important influence.Loading and unloading of the establishment of the standard operating procedure,which can improve the efficiency of the loading operation,improve the quality of the goods truck safety,to provide greater security for the automobile logistics enterprise.Japan's Toyota motor logistics started earlier,they advanced its car carrier loading technology,worthy of reference and learning.This article obtains from the analysis of Toyota system standard operation,put forward improvement ideas about the present situation of domestic car transport vehicle load,by improving the training system,strengthen the training of workers,improve the efficiency of its transport vehicle loading and unloading operation and the quality of the goods vehicle safety.%装卸作业是汽车物流的重要组成部分,在整车物流运输业务方面具有重要的影响。装卸标准作业流程的建立,能提高装载作业的效率,提高对商品车品质安全,为汽车物流企业提供更大的安全保障。日本的丰田汽车物流起步较早,他们先进的轿运车装载技术,值得借鉴和学习。文中从分析丰田体系标准作业入手,对国内轿运车装载现状提出改善构想,通过完善培训体系,加强对作业人员的培训,实现提高轿运车装卸作业效率与商品车的品质安全。

  1. Study of General Applicability and Particularity of Management Basis on Toyota Management%从丰田模式的发展看管理学的普适性和特殊性

    Institute of Scientific and Technical Information of China (English)

    常文娟

    2012-01-01

    在认同“社会科学领域内存在着普适的管理学”这一理论前题的条件下,通过剖析丰田管理模式与科学管理及文化之间的关系,探索决定管理学普适性和特殊性的因素。科学管理的思想决定了管理学的普适性,而科学管理思想与不同文化环境的结合决定了管理学的特殊性。%This article agrees with that there would be a generally applicable management theory in the field of social sciences. After analyzing the relationship between the Toyota Management and the scientific management and the culture , the deciding factors of the general applicability and particularity are explored. The conclusion is that the general applicability is determined by the thoughts of scientific management , and the particularity is determined by different cultures.

  2. Hyperspectral-Augmented Target Tracking

    Science.gov (United States)

    2008-03-01

    Make Model 1 White Volvo 740 GL 2 Black Mitsubishi Montero 3 White Honda Accord 4 Black Jeep Grand Cherokee 5 Maroon Toyota Camry 6 Dark Blue...Landrover Discovery 7 Blue Chevy Colorado 8 Gold Honda Odyssey 9 Silver Nissan Altima 10 Gold Honda Accord 11 Red VW Beetle Continued on next page 3-11 Table...Gold Saturn SL2 16 Gold Nissan Maxima 17 Red Saturn SL2 18 Black Pontiac Grand Am 19 Silver Ford Focus 20 Gray with Black top Chrysler Sebring

  3. 国有企业丰田生产方式本土化标准研究%Research on Standard System of Toyota production system localization in the State-Owned Enterprise

    Institute of Scientific and Technical Information of China (English)

    李卓

    2012-01-01

    以“准时生产JIT”和“自动化”作为两大支柱的丰田生产方式(TPS)凭借其完整、超常规、最具革命性的全新生产方式被称为“改变世界的机器”.精益生产、持续改善等专门用语出现在全球制造业并成为争相学习、效仿的对象.国有企业在TPS本土化的道路上由于缺乏对其本质的理解和研究,照搬全抄、形式主义的学习方式只能步履维艰.文章以史为鉴,在吸取丰田经验教训的基础上,提出国有企业学习TPS的标准与方法,为TPS本土化提供依据和方向.%Based on "just-in-time production" and "automatic", the Toyota production system (TPS) is named "the machine that changed the world" as a complete, extraordinaryandthe most revolutionary new production system. Lean production, continuous improvement and other special terms involved in TPS appear in the global manufacturing industry and become the object to study or follow.Lack of localization of the essence of the understanding and research, it' s rather difficult for the state-owned enterprise to use it to optimize the processes of enterprises in formalism ways of learning.Taking history as a mirror, the study considers how the TPS produce, develop and improve,learning from the experience,proposea set of standards and effectiveways for the state-owned enterprise to take an advance in management and give the directionfor TPS localization.

  4. Metadecision in the toyota management model

    OpenAIRE

    Torres Júnior, Alvair Silveira

    2010-01-01

    O processo decisório no modelo de produção enxuta aparece como um fator pouco explorado na literatura. Os elementos que compõem o processo decisório aparecem marginalmente quando se discutem fatores como just-in-time, as parcerias com fornecedores, o desenvolvimento de produtos e a qualidade embutida no processo. O objetivo desta pesquisa é explorar como o processo decisório se apresenta no modelo de produção enxuta. Foram desenvolvidas entrevistas em profundidade com três ex-executivos do pr...

  5. Battery Ownership Model - Medium Duty HEV Battery Leasing & Standardization

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, Ken; Smith, Kandler; Cosgrove, Jon; Prohaska, Robert; Pesaran, Ahmad; Paul, James; Wiseman, Marc

    2015-12-01

    Prepared for the U.S. Department of Energy, this milestone report focuses on the economics of leasing versus owning batteries for medium-duty hybrid electric vehicles as well as various battery standardization scenarios. The work described in this report was performed by members of the Energy Storage Team and the Vehicle Simulation Team in NREL's Transportation and Hydrogen Systems Center along with members of the Vehicles Analysis Team at Ricardo.

  6. Multinational automobile manufacture enterprise internationalization management strategy——take Toyota Automobile as example%跨国汽车制造企业国际化经营战略及启示——以丰田汽车为例

    Institute of Scientific and Technical Information of China (English)

    周文辉; 钱春丽

    2011-01-01

    本文以日本丰田汽车公司为研究对象,对其国际化经营轨迹和经营战略进行了比较研究。先对其国际化历程进行了追溯,进而提炼其国际化经营战略的共性特点,分析了其国际化经营的优势来源,最后结合我国汽车制造企业国际化发展现状给出我国同业企业国际化经营战略制定与实施的对策建议。%General Toyota of Japan were taken as examples for the purpose of comparison study on their processes and strategies in the course of globalization.Globalization processe was firstly introduced and then similarities in globalization strategie was drawn from history study.Sources of competitiveness was also analyzed.In the end suggestions on globalization were given to our local automobile manufacturers on the basis of environmental analysis.

  7. Temperature rise and Heat build up inside a parked Car

    Science.gov (United States)

    Coady, Rose; Maheswaranathan, Ponn

    2001-11-01

    We have studied the heat build up inside a parked car under the hot summer Sun. Inside and outside temperatures were monitored every ten seconds from 9 AM to about 4 PM for a 2000 Toyota Camry parked in a Winthrop University parking lot without any shades or trees. Two PASCO temperature sensors, one inside the car and the other outside the car, are used along with PASCO-750 interface to collect the data. Data were collected under the following conditions while keeping track of the outside weather: fully closed windows, slightly open windows, half way open windows, fully open windows, and with window shades inside and outside. Inside temperatures reached as high as 150 degrees Fahrenheit on a sunny day with outside high temperature of about 100 degrees Fahrenheit. These results will be presented along with results from car cover and window tint manufacturers and suggestions to keep your car cool next time you park it under the Sun.

  8. Hydrogen: the great debate. 'Power to Gas - how to cope with the challenge of electricity storage?; Hydrogen in energy transition: which challenges to be faced?; Hydrogen, essential today, indispensable tomorrow; Electrolytic hydrogen, a solution for energy transition?; Development of high power electrolysis systems: need and approach; Hydrogen as energy vector, Potential and stakes: a perspective; The Toyota Fuel Cell System: a new era for the automotive industry; Three key factors: production, applications to mobility, and public acceptance; Hydrogen, benevolent fairy or tempting demon

    International Nuclear Information System (INIS)

    Hauet, Jean-Pierre; Boucly, Philippe; Beeker, Etienne; Mauberger, Pascal; Quint, Aliette; Pierre, Helene; Lucchese, Paul; Bouillon-Delporte, Valerie; Chauvet, Bertrand; Brisse, Annabelle; Gautier, Ludmila; Hercberg, Sylvain; De Volder, Marc; Gruson, Jean-Francois; Marion, Pierre; Grellier, Sebastien; Devezeaux, Jean-Guy; Mansilla, Christine; Le Net, Elisabeth; Le Duigou, Alain; Maire, Jacques

    2015-01-01

    This publication proposes a set of contributions which address various issues related to the development of the use of hydrogen as an energy source. More precisely, these contributions discuss how to face the challenge of electricity storage by using the Power-to-Gas technology, the challenges to be faced regarding the role of hydrogen in energy transition, the essential current role of hydrogen and its indispensable role for tomorrow, the possible role of electrolytic hydrogen as a solution for energy transition, the need of and the approach to a development of high power electrolysis systems, the potential and stakes of hydrogen as an energy vector, the Toyota fuel cell system as a sign for new era for automotive industry, the three main factors (production, applications to mobility, and public acceptance) for the use of hydrogen in energy transition, and the role of hydrogen perceived either as a benevolent fairy or a tempting demon

  9. The Electronic-controlled Engine's Fault Analog System Design Based on Toyota Lexus 1UZ-FE%基于丰田凌志1UZ-FE电控发动机故障模拟系统设计

    Institute of Scientific and Technical Information of China (English)

    贺大松

    2012-01-01

    To improve the engine electronic control technology theory and maintenance technology teaching effect, the meaningful Toyota Lexus 1UZ-FE electric engine has been chosen for training in this paper.Combined with the engine control circuit common fault diagnosis and testing ideas,we designed the hardware and software system and the single-chip microcomputer and circuit system are simulated by the single-chip microcomputer simulation software Proteus.It is shown that the system can set practical fault effectively and improve stability through the hardware and software matching,which can provide good fault detection and diagnosis learning platform for maintenance personnel and higher vocational students.%为提高发动机电控技术理论与维修技术的教学效果,本文选用具有代表意义的丰田凌志1UZ-FE电控发动机进行实训系统设计,结合发动机控制电路常见故障的诊断和检测思路,完成了对系统硬件和软件的设计,并通过单片机模拟仿真软件Proteus进行了单片机和电路系统的仿真。仿真结果表明,通过硬件与软件匹配,可有效设置实际故障,并且实训系统工作稳定,可为汽车维修人员和高职学生提供良好的故障检测与诊断学习平台。

  10. The Toyota Way and the Crisis: a New Industrial Divide

    OpenAIRE

    A. Camuffo; D.R. Weber

    2012-01-01

    The recent wave of recalls has shed new light on Toyota’s evolution and on its potential effects on the global automotive industry. The worsening of Toyota’s financial and market performance may be transitory, and has been exacerbated by the global crisis of 2009. However, it may also be the symptom of deeper and longer lasting problems, rooted in a reduced capacity of Toyota’s capabilities and management systems to cope with the changing competitive landscape of the automotive industry. ...

  11. The new Toyota variable valve timing and lift system

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, K.; Fuwa, N.; Yoshihara, Y. [Toyota Motor Corporation (Japan); Hori, K. [Toyota Boshoku Corporation (Japan)

    2007-07-01

    A continuously variable valve timing (duration and phase) and lift system was developed. This system was applied to the valvetrain of a new 2.0L L4 engine (3ZRFAE) for the Japanese market. The system has rocker arms, which allow continuously variable timing and lift, situated between a conventional roller-rocker arm and the camshaft, an electromotor actuator to drive it and a phase mechanism for intake and exhaust camshafts (Dual VVT-i). The rocking center of the rocker arm is stationary, and the axial linear motion of a helical spline changes the initial phase of the rocker arm which varies the timing and lift. The linear motion mechanism uses an original planetary roller screw and is driven by a brushless motor with a built-in electric control unit. Since the rocking center and the linear motion helical spline center coincide, a compact cylinder head design was possible, and the cylinder head is a common design with a conventional engine. Since the ECU controls intake valve duration and timing, a fuel economy gain of maximum 10% (depending on driving condition) is obtained by reducing light to medium load pumping losses. Also intake efficiency was maximized throughout the speed range, resulting in a power gain of 10%. Further, HC emissions were reduced due to increased air speed at low valve lift. (orig.)

  12. Theory Z and Schools: What Can We Learn from Toyota?

    Science.gov (United States)

    George, Paul S.

    1984-01-01

    William Ouchi's 1981 book designates as "Type Z" American firms that effectively combine domestic and Japanese management strategies. Applications of this theory to improving school effectiveness would involve combining in each school the components of vital philosophy, curricular clarity, instructional focus, social organization, and…

  13. Analisis Pengaruh Bauran Pemasaran Terhadap Keputusan Pembelian Mobil Merek Toyota Agya (Studi Kasus Pada Toyota Auto 2000 Sisingamangaraja Medan)

    OpenAIRE

    Maha, Kevin Allan

    2016-01-01

    Marketing mix is a set of tactical marketing tool and controlled by the company combined to produce the desired response target market consist of product , price , distribution channels and promotion . The concept of modern marketing orientation on the needs and desires of consumers . The first step of this strategy to understand the wants, needs and tastes of consumers (customer is king ) . If the car industry wants to continue to exist in the automotive market , it must remain consistent wi...

  14. Hybrid Car Creates Hybrid Organization: Development of Toyota's First Prius Model and Limits that Traditional Development Organization at Toyota confronted

    OpenAIRE

    Niihara, Hiroaki

    2010-01-01

    The manager of each function-based department holds private information about his or her respective department's fields of expertise and technological advances. Given this understanding, it may be advisable for the company's headquarters to delegate decision-making authority to the managers of these individual departments. However, if decision-making authority is delegated to individual departments or to the managers representing the interests of each of those departments, those departments m...

  15. Analisis Pengaruh Ekuitas Merek Terhadap Keputusan Pembelian Mobil Toyota New Avanza (Studi Kasus Toyota Auto 2000 Sisimangaraja)

    OpenAIRE

    Lubis, Faisal Afif

    2016-01-01

    Brand equity consists of several elements, such as brand awareness is the ability of a potential buyer to recognize, recall a brand as part of a particular product category. The role of brand awareness in brand equity will depend on the level of achievement of awareness in the minds of consumers. Brand association impression that everything that comes to mind someone associated with his memory about a brand. The impression that the quality of the overall customer perception ...

  16. Driver Injury Risk Variability in Finite Element Reconstructions of Crash Injury Research and Engineering Network (CIREN) Frontal Motor Vehicle Crashes.

    Science.gov (United States)

    Gaewsky, James P; Weaver, Ashley A; Koya, Bharath; Stitzel, Joel D

    2015-01-01

    A 3-phase real-world motor vehicle crash (MVC) reconstruction method was developed to analyze injury variability as a function of precrash occupant position for 2 full-frontal Crash Injury Research and Engineering Network (CIREN) cases. Phase I: A finite element (FE) simplified vehicle model (SVM) was developed and tuned to mimic the frontal crash characteristics of the CIREN case vehicle (Camry or Cobalt) using frontal New Car Assessment Program (NCAP) crash test data. Phase II: The Toyota HUman Model for Safety (THUMS) v4.01 was positioned in 120 precrash configurations per case within the SVM. Five occupant positioning variables were varied using a Latin hypercube design of experiments: seat track position, seat back angle, D-ring height, steering column angle, and steering column telescoping position. An additional baseline simulation was performed that aimed to match the precrash occupant position documented in CIREN for each case. Phase III: FE simulations were then performed using kinematic boundary conditions from each vehicle's event data recorder (EDR). HIC15, combined thoracic index (CTI), femur forces, and strain-based injury metrics in the lung and lumbar vertebrae were evaluated to predict injury. Tuning the SVM to specific vehicle models resulted in close matches between simulated and test injury metric data, allowing the tuned SVM to be used in each case reconstruction with EDR-derived boundary conditions. Simulations with the most rearward seats and reclined seat backs had the greatest HIC15, head injury risk, CTI, and chest injury risk. Calculated injury risks for the head, chest, and femur closely correlated to the CIREN occupant injury patterns. CTI in the Camry case yielded a 54% probability of Abbreviated Injury Scale (AIS) 2+ chest injury in the baseline case simulation and ranged from 34 to 88% (mean = 61%) risk in the least and most dangerous occupant positions. The greater than 50% probability was consistent with the case occupant's AIS 2

  17. 77 FR 35428 - Certain Automotive GPS Navigation Systems, Components Thereof, and Products Containing Same...

    Science.gov (United States)

    2012-06-13

    ... Warwickshire, United Kingdom; Toyota Motor Corporation of Toyota City, Japan; Toyota Motor North America, Inc. of Torrance, California; Toyota Motor Engineering & Manufacturing North America, Inc. of Erlanger, Kentucky; Toyota Motor Manufacturing, Indiana, Inc. of Princeton, Indiana; Toyota Motor Manufacturing...

  18. NANO-BATTERY TECHNOLOGY FOR EV-HEV PANEL: A PIONEERING STUDY

    OpenAIRE

    Ataur Rahman; M. Rashid; A. K. M. Mohiuddin; M. N. A. Hawlader

    2015-01-01

    Global trends toward CO2 reduction and resource efficiency have significantly increased the importance of lightweight materials for automobile original equipment manufacturers (OEM). CO2 reduction is a fundamental driver for a more lightweight automobile. The introduction of Electrical Vehicles (EVs) is one initiative towards this end. However EVs are currently facing several weaknesses: limited driving range, battery pack heaviness, lack of safety and thermal control, high cost, and overall ...

  19. Recovery of valuable metals from spent HEV NiMH battery leach solutions

    OpenAIRE

    Ricknell, Jonas

    2017-01-01

    As the demand on resources is increasing worldwide, the process of recycling material has become more important. The specific recycling of metals used in car batteries, and more specifically in the large batteries used in hybrid electric vehicles, is a rising concern where the industrially implemented recycling processes concerning these batteries that exist today are often highly pollutant and energy consuming. In the present study, an alternative hydrometallurgical recycling process of the ...

  20. Efficient Propulsion Structure with an Axial Flux Rotary Converter for HEV Drive Unit

    Directory of Open Access Journals (Sweden)

    Ales Havel

    2011-01-01

    Full Text Available This paper describes an efficient axial flux arrangement of the four quadrant rotary converter for hybrid electric vehicles. The design of the axial flux wound stator and both axial flux squirrel cage rotors is based on the arrangement of radial air gap induction motor and permanent magnet synchronous motor. The method of constant magnetic circuit volume is utilized for dimensions conversion, which results into basic dimensions of stator and rotor discs in axial flux conception. This allows the creation of real 3D models in the CAD application. Finally, the finite element simulations of electromagnetic induction in the axial flux stator pack are presented in the concluding part of this paper.

  1. NANO-BATTERY TECHNOLOGY FOR EV-HEV PANEL: A PIONEERING STUDY

    Directory of Open Access Journals (Sweden)

    Ataur Rahman

    2015-11-01

    Full Text Available Global trends toward CO2 reduction and resource efficiency have significantly increased the importance of lightweight materials for automobile original equipment manufacturers (OEM. CO2 reduction is a fundamental driver for a more lightweight automobile. The introduction of Electrical Vehicles (EVs is one initiative towards this end. However EVs are currently facing several weaknesses: limited driving range, battery pack heaviness, lack of safety and thermal control, high cost, and overall limited efficiency. This study presents a panel-style nano-battery technology built into an EV with CuO filler solid polymer electrolyte (SPE sandwiched by carbon fiber (CF and lithium (Li plate. In addition to this, an aluminum laminated polypropylene film is used as the electromagnetic compatibility (EMC shield. The proposed battery body panel of the EV would reduce the car weight by about 20%, with a charge and discharge capacity of 1.5 kWh (10% of car total power requirement, and provide the heat insulation for the car which would save about 10% power consumption of the air conditioning system. Therefore, the EV would be benefited by 30% in terms of energy reduction by using the proposed body. Furthermore, the proposed body is considered environmental-friendly since it is recyclable for use in a new product. However, the main limiting factors of the SPE are its thermal behavior and moderate ionic conductivity at low temperatures. The SPE temperature is maintained by controlling the battery panel charging/discharge rate. It is expected that the proposed panel-style nano-battery use in an EV would save up to 6.00 kWh in battery energy, equivalent to 2.81 liters of petrol and prevent 3.081 kg of CO2 emission for a travel distance of 100 km. KEYWORDS: epoxy resin; carbon fiber; lithium thin plate; energy generation; solid electrolyte battery

  2. Battery Power Management in Heavy-duty HEVs based on the Estimated Critical Surface Charge

    Science.gov (United States)

    2011-03-01

    energy flows through the system reach up to the marginal values during aggressive acceleration or braking . The underlying phenomenon determining the...the system reach up to the marginal values during aggressive acceleration or braking . The underlying phenomenon determining the limits is closely...where Pbatt.min is the minimum allowable battery power. When negative power demand is requested by the driver, regenerative braking mode is

  3. Improved Battery Parameter Estimation Method Considering Operating Scenarios for HEV/EV Applications

    Directory of Open Access Journals (Sweden)

    Jufeng Yang

    2016-12-01

    Full Text Available This paper presents an improved battery parameter estimation method based on typical operating scenarios in hybrid electric vehicles and pure electric vehicles. Compared with the conventional estimation methods, the proposed method takes both the constant-current charging and the dynamic driving scenarios into account, and two separate sets of model parameters are estimated through different parts of the pulse-rest test. The model parameters for the constant-charging scenario are estimated from the data in the pulse-charging periods, while the model parameters for the dynamic driving scenario are estimated from the data in the rest periods, and the length of the fitted dataset is determined by the spectrum analysis of the load current. In addition, the unsaturated phenomenon caused by the long-term resistor-capacitor (RC network is analyzed, and the initial voltage expressions of the RC networks in the fitting functions are improved to ensure a higher model fidelity. Simulation and experiment results validated the feasibility of the developed estimation method.

  4. Q/SdR.04.896-2008 SQR7130A217/Model A Car

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    1.Background As the development of global economy demands an increasingly large quantity of energy,the energy crisis is getting more severe.Auto manufacturers in Japan,America,and Europe have all began to develop hybrid power vehicles or its technology platform since 1990s,so as to save energy.Relied on its THS system which consists of the planet wheel and e-CVT,TOYOTA developed a series of strong hybrid power vehicles,such as Prius,Lexus,Highlander,Camry,etc.Based on its IMA system,HONDA developed a series of mild hybrid power vehicles,such as Insight,Civic,Accord,etc.On the basis of its Belt-driven Starter Generator (BSG) system,French SPA Group developed a series of weak hybrid power vehicles,such as Citroen C3,Citroen C2,Citroen 1007,Citroen 207,etc.In America the research of hybrid power vehicle is being done actively by a group of relevant parties consisting of Department of Transport,Department of Defense,major auto companies and relevant organizations under the leadership of Department of Energy and with the large quantity ofinvestment from GE Motors Co.and CHRYSLER.

  5. Safety and interaction of patients with implantable cardiac defibrillators driving a hybrid vehicle.

    Science.gov (United States)

    Tondato, Fernando; Bazzell, Jane; Schwartz, Linda; Mc Donald, Bruce W; Fisher, Robert; Anderson, S Shawn; Galindo, Arcenio; Dueck, Amylou C; Scott, Luis R

    2017-01-15

    Electromagnetic interference (EMI) can affect the function of implantable cardioverter defibrillators (ICD). Hybrid electric vehicles (HEV) have increased popularity and are a potential source of EMI. Little is known about the in vivo effects of EMI generated by HEV on ICD. This study evaluated the in vivo interaction between EMI generated by HEV with ICD. Thirty patients (73±9 y/o; 80% male) with stable ICD function were exposed to EMI generated by a Toyota Prius Hybrid®. The vehicle was lifted above the ground, allowing safe changes in engine rotation and consequent variations in electromagnetic emission. EMI was measured (NARDA STS® model EHP-50C) and expressed in A/m (magnetic), Volts/m (electrical), and Hertz (frequency). Six positions were evaluated: driver, front passenger, right and left back seats, outside, at the back and front of the car. Each position was evaluated at idle, 30 mph, 60 mph and variable speeds (acceleration-deceleration-brake). All ICD devices were continuously monitored during the study. The levels of EMI generated were low (highest mean levels: 2.09A/m at right back seat at 30 mph; and 3.5V/m at driver seat at variable speeds). No episode of oversensing or inadvertent change in ICD programming was observed. It is safe for patients with ICD to interact with HEV. This is the first study to address this issue using an in vivo model. Further studies are necessary to evaluate the interaction of different models of HEV or electric engine with ICD or unipolar pacemakers. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. Path dependence, initial conditions, and routines in organizations : The Toyota production system re-examined

    NARCIS (Netherlands)

    Dolfsma, W.A.; van Driel, H.

    2009-01-01

    Purpose - The purpose of this paper is to disentangle and elaborate on the constitutive elements of the concept of path dependence (initial conditions and lock-in) for a concerted and in-depth application to the study of organizational change. Design/methodology/approach - The approach takes the

  7. Applying Lean/Toyota production system principles to improve phlebotomy patient satisfaction and workflow.

    Science.gov (United States)

    Melanson, Stacy E F; Goonan, Ellen M; Lobo, Margaret M; Baum, Jonathan M; Paredes, José D; Santos, Katherine S; Gustafson, Michael L; Tanasijevic, Milenko J

    2009-12-01

    Our goals were to improve the overall patient experience and optimize the blood collection process in outpatient phlebotomy using Lean principles. Elimination of non-value-added steps and modifications to operational processes resulted in increased capacity to handle workload during peak times without adding staff. The result was a reduction of average patient wait time from 21 to 5 minutes, with the goal of drawing blood samples within 10 minutes of arrival at the phlebotomy station met for 90% of patients. In addition, patient satisfaction increased noticeably as assessed by a 5-question survey. The results have been sustained for 10 months with staff continuing to make process improvements.

  8. Seeking perfection in healthcare. A case study in adopting Toyota Production System methods.

    Science.gov (United States)

    Kaplan, Gary S; Patterson, Sarah H

    2008-01-01

    Virginia Mason Health System's vision to be the quality leader in healthcare means continually adopting new ways of thinking. One change has been shifting from believing defects are to be expected to believing zero defects in healthcare is not only possible, but also necessary. Generally, healthcare has advanced in technology and understanding of disease, but its business and management systems have changed little since the 1950s. Virginia Mason realized it needed a management method to help make real and measurable improvements in safety, quality, service and staff satisfaction.

  9. Supply Chain Security. Tools, Trends, and Techniques : Toyota and Honda cases

    OpenAIRE

    Klimova, Nadezda; Akimova, Anna

    2011-01-01

      Supply chain management has experienced great changes within the last fifty years. Inevitably, many companies entered the global market with the prime intention to achieve their defined goals. In comparison with the local markets, the global environment requires more efforts and changes in the supply chain operation in order to remain viable in business. Several business models are introduced for achieving the success in the market, suggested by the following researchers: Liker, Choi, Ronal...

  10. Global energy and environmental issues, reflected in Toyota's advanced powertrain development

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Toshiaki [Toyota Motor Corporation, Aichi (Japan)

    2013-08-01

    Energy diversification is proceeding due to environmental issues and need for energy security. At the same time, the environmental challenges for the automobile are becoming more and more severe due to the requirement for low fuel consumption and air pollution. While the alternative fuels are expanding due to concerns on future oil supply, automakers need to promote multi-directional developments. However it is considered that oil will remain as the main fuel source in the next few decades. Thus, the development of internal combustion engine (ICE) and of high efficiency vehicle systems will remain an important challenge. Furthermore hybrid vehicle (HV) technology and plug-in hybrid electric vehicle (PHEV) technology are expected to be one effective technology to save oil usage. For that purpose, promoting electricity production which emits low CO{sub 2} and the development of a high energy density battery is important. In addition to the energy issue, air pollution issue is also an important matter. Although the emission regulations are continuously becoming more stringent to respond to the air pollution issue, many areas have a mismatch between emission regulation and suitable fuel quality. Therefore automakers are taking action for resolving the contradiction. Since it will take time until fuel quality meets the required specification, developing the technologies to prevent the major matters for consumers can't be avoided. Coordination of fuel properties and quality over a wide area is essential for improving air quality locally and globally. (orig.)

  11. Reducing door-to-needle times using Toyota's lean manufacturing principles and value stream analysis.

    Science.gov (United States)

    Ford, Andria L; Williams, Jennifer A; Spencer, Mary; McCammon, Craig; Khoury, Naim; Sampson, Tomoko R; Panagos, Peter; Lee, Jin-Moo

    2012-12-01

    Earlier tissue-type plasminogen activator (tPA) treatment for acute ischemic stroke increases efficacy, prompting national efforts to reduce door-to-needle times. We used lean process improvement methodology to develop a streamlined intravenous tPA protocol. In early 2011, a multidisciplinary team analyzed the steps required to treat patients with acute ischemic stroke with intravenous tPA using value stream analysis (VSA). We directly compared the tPA-treated patients in the "pre-VSA" epoch with the "post-VSA" epoch with regard to baseline characteristics, protocol metrics, and clinical outcomes. The VSA revealed several tPA protocol inefficiencies: routing of patients to room, then to CT, then back to the room; serial processing of workflow; and delays in waiting for laboratory results. On March 1, 2011, a new protocol incorporated changes to minimize delays: routing patients directly to head CT before the patient room, using parallel process workflow, and implementing point-of-care laboratories. In the pre and post-VSA epochs, 132 and 87 patients were treated with intravenous tPA, respectively. Compared with pre-VSA, door-to-needle times and percent of patients treated ≤60 minutes from hospital arrival were improved in the post-VSA epoch: 60 minutes versus 39 minutes (PLean process improvement methodology can expedite time-dependent stroke care without compromising safety.

  12. From Toyota to the bedside: nurses can lead the lean way in health care reform.

    Science.gov (United States)

    Johnson, Joyce E; Smith, Amy L; Mastro, Kari A

    2012-01-01

    The advent of health care reform means new pressures on American hospitals, which will be forced to do more with less. In the next decade, increased use of "Lean" principles and practices in hospitals can create real value by reducing waste and improving productivity, costs, quality, and the timely delivery of patient care services. In 2010, the Institute of Medicine recommended that nurses lead collaborative quality improvement efforts and assume a major role in redesigning health care in the United States. In this article, we provide an overview of the use of Lean techniques in health care and 2 case studies of successful, nurse-directed Lean initiatives at the Robert Wood Johnson University Hospital. The article concludes with some lessons we have learned and implications for nursing education in the future that must include the concepts, tools, and skills required for adapting Lean to the patient care environment.

  13. Bauran Pemasaran Jasa, Pengaruhnya terhadap Kepuasan Konsumen Pengguna Mobil Toyota Avanza Veloz PT. Hasjrat Abadi Manado

    OpenAIRE

    Wowor, Valdy Ronald

    2013-01-01

    Perkembangan teknologi dunia yang sangat pesat saat ini, menyebabkan semua Perusahaan perotomotifan harus berpikir lebih keras untuk menciptakan produk yang unggul dengan menerapkan strategi-strategi pemasaran. Bauran Pemasaran merupakan salah satu strategi pemasaran untuk meningkatkan jumlah penjualan sebuah produk. Seiring dengan perkembangan zaman, kini orientasi berpikir Perusahaan perotomotifan tidak saja pada penciptaan produk unggul, namun bagaimana kepuasan konsumen menjadi tujuan uta...

  14. 77 FR 29449 - Toyota Motor Corporation, Inc., Grant of Petition for Decision of Inconsequential Noncompliance

    Science.gov (United States)

    2012-05-17

    ... to consumers and would not impair a consumer's ability to locate the lower anchorages. (2) Paragraph... consumers' ability to find the LATCH anchorages. While anchor bars are permitted to be as short as 25 mm in... longitudinal vertical plane tangent to the side of the anchorage bar. If a person were to probe the seat bight...

  15. Design,the vital element for Toyota%Toyota的设计核心:J-factor

    Institute of Scientific and Technical Information of China (English)

    许鸿德

    2005-01-01

    一提到Toyota,我们脑海中浮现的是高品质,稳定可靠与平易近人(另一面就是“为数众多”),鲜小人会将Toyota的产品与“设计”连在一块。但是在超越Ford成为世界上第二大车厂后,Toyota高层很清楚若要成为全球车坛的龙头老大,除了凭借该厂在生产与品管领域的优势之外,更需要世界第一流的汽车设计能力,以推出符合世界各地消费者口味的产品!Toyota全球设计总监Wahol Hirai更誓言将“日工风格”(J-factor)带入未来Toyota车型的设计元素中。

  16. Toyota A3 report: a tool for process improvement in healthcare.

    Science.gov (United States)

    Lee, Te-Shu; Kuo, Mu-Hsing

    2009-01-01

    It is proposed that the A3 problem solving process be used by hospital staff to improve its healthcare workflow. A hypothetical case study is given to demonstrate the applicability and benefits of the methodology. The research results show that A3 is a useful tool for healthcare organizations seeking to continuously improve their healthcare service quality.

  17. [Clinical result of testicular sperm extraction (TESE) to male-factor infertility in Toyota Memorial Hospital].

    Science.gov (United States)

    Kubota, Yasuaki; Tamaki, Masayoshi; Maeda, Shinichi; Katsumata, Yoshinari; Moriwaki, Takayuki; Tashiro, Kazuhiro; Deguchi, Takashi

    2005-01-01

    Owing to progress of assisted reproduction technology in recent years, it has become possible for couples with infertility problems to have children. Between March 1998 and May 2003 testicular sperm extraction (TESE) was performed on 30 men with male-factor infertility in our hospital. Consequently, we succeeded in recovering 20 spermatozoa. Intracytoplasmic sperm injection was subsequently performed in 15 couples and resulted in 8 pregnancies. There was a statistically significant difference in follicle-stimulating hormone, luteirizing hormone and Johnsen's score between the non-obstructive groups with successful TESE and those with unsuccessful TESE.

  18. Development of Toyota new 1GZ-FE engine; Shingata V12 gasoline engine no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Kawamura, H; Asahi, T; Goto, M; Endo, K; Terada, M [Toyota Motor Corp., Aichi (Japan)

    1997-10-01

    The first V-12 cylinder engine for passenger car in Japan, the 1GZ-FE, which is the status of high luxury vehicles has been developed. In order to proceed the merit of V-12 cylinder engine, Intelligent Variable Valve Timing (VVT-i) system, Slant squish combustion chamber, Iridium pole spark plug and Intelligent electronic throttle control system were introduced. Through these features this new 1GZ-FE has achieved an overwhelming smoothness and quietness and yet highest torque among the same displacement engine at low and medium engine speed. Additionally the 1GZ-FE achieved good fuel economy and high reliability which exceed any other competitors. 14 refs., 4 figs.

  19. Toxics, Toyotas, and terrorism: the behavioral economics of fear and stigma.

    Science.gov (United States)

    Schulze, William; Wansink, Brian

    2012-04-01

    Economists have traditionally viewed the behavioral response to risk as continuous and proportional. In contrast, psychologists have often contended that people have little control over their response to risk that is dichotomous, nonproportional, visceral, and fear based. In extreme cases, this automatic response results in the stigmatization of a product, technology, or choice, which seemingly cannot be eliminated or reduced. In resolving these contrasting perspectives, we review four recent studies that blend behavioral economics and psychology. Together, they provide evidence for a dual-process decision model for risk that incorporates both reason and fear. They show consumers' responses to perceived risk as a mix of proportional and dichotomous (safe/unsafe) responses that are relatively more continuous in situations where deliberation is possible, and more dichotomous in emotional or stressful circumstances. These findings reconcile mixed results in past studies, and, more importantly, the dual-process model allows a clear definition of stigma, and suggests new ways to mitigate stigma and to help manage potentially damaging overreactions to it. © 2012 Society for Risk Analysis.

  20. "Toyota" Production system as ability to rise effectivity and competitiveness for business entity

    OpenAIRE

    Kvetinskaya, A. V.; Кветинская, А. В.

    2013-01-01

    The article investigates Toyota’s system of production. The main principles of Lean production are described, such as Kaidzen”, “Just-in-Time”, “5 S” system, “Muda”, “Muri”, “Mura” and possibilities to adopt this system in Russian factories. В данной статье исследуется система производства которая используется в компании "Тойота". Описаны основные принципы "бережливого" производства, такие как "Кайдзен", "Точно в срок", "5С", "Муда", "Мури", "Мура" и описаны возможности применения данной с...

  1. Analytical Hierarchy Process Approach on Consumer Preference of Toyota Agya, Daihatsu Ayla, Honda Brio in Manado

    OpenAIRE

    Handoko, Agnes Maria

    2015-01-01

    The automobile industry in Manado has grown rapidly. So many type of car launched to fulfill the customer need for their daily mobility. Follow the current situation, where price of fuel increasing continously, and pollution level has increase day by day, the car producer react by launched a several type of small car. The purpose of this research are to determine which criteria in the small car is mostly selected by customers and to define which small car that customers like the most. This re...

  2. Pengaruh Promosi Penjualan Terhadap Keputusan Pembelian Toyota Avanza (Studi Pada Auto 2000 Gatot Subroto Medan)

    OpenAIRE

    Sari, Mufida

    2016-01-01

    Growing interest in public purchasing of car affect competition between companies selling their cars in attracting buyers. One of the efforts the company do to face the competition is doing a sales promotion. Sales promotion activities by the company may seek an increase in sales by influencing purchase decisions of potential customers .. Sales promotion is any deals or short-term incentives that directed to the buyer , retailer or wholesaler and designed to gather a specific response and imm...

  3. Skulle det være en Foster eller en Toyota?

    DEFF Research Database (Denmark)

    Vibæk, Kasper Sánchez

    2006-01-01

    Japanske husproducenter leverer nøglefærdige huse fra fabrik. De styrede produktionsforhold og det at der produceres ud fra en katalog tankegang har betydning for det arkitektoniske udtryk. Artiklen beskriver og analyserer konsekvenserne af dette....

  4. EVALUASI WAKTU PROSES SUPPLY SMALL PART DENGAN MEMPERHATIKAN BEBAN KERJA DI PT. TOYOTA MOTOR MANUFACTURING INDONESIA

    Directory of Open Access Journals (Sweden)

    Dene Herwanto

    2018-01-01

    The calculations show that the operator workload with Gentan-i time is higher than the workload with the standard time that takes into account the performance rating and allowance. One of the improvements to be proposed is to balance some tasks of route A supply to the other route so that the overall workload becomes more balanced.

  5. The impact of price changes on the brand equity of Toyota in Saudi Arabia

    OpenAIRE

    Ezzat, AM

    2014-01-01

    Document 3 describes the research methodology used in this qualitative case study, the rationale/justification for the methodology and reports the findings with an analysis of the findings. The purpose of the study is to investigate and describe the effect of sudden price changes on consumer purchasing behaviour and attitudes toward brand equity. The qualitative case study consists of 6 mini focus group each were comprised of between 3-5 participants who are Saudi national car owners of Toyot...

  6. Pengelolaan dan Pengembangan USAha Distribusi Mobil Toyota pada Ud. Asri Motor di Surabaya

    OpenAIRE

    Anggrean, Christian

    2013-01-01

    Tujuan dari pada penelitian ini adalah mendeskripsikan pengelolaan Perusahaan keluarga, melakukan analisa kondisi internal dan eksternal dengan analisis SWOT, menyusun strategi pengembangan bisnis pada UD. Asri Motor. Penelitian ini merupakan penelitian kualitatif deskriptif dengan metode pengumpulan data wawancara. Hasil yang diperoleh dari penelitian ini menunjukkan bahwa pengelolaan fungsi manajemen Perusahaan yang terdiri atas planning, organizing, actuating, controlling sudah berjalan de...

  7. Dual-Electrical-Port Control of Cascaded Doubly-Fed Induction Machine for EV/HEV Applications

    DEFF Research Database (Denmark)

    Han, Peng; Cheng, Ming; Chen, Zhe

    2017-01-01

    that of the power machine in singly-fed operation mode, and only a half of that of the power machine in doubly-fed operation mode, which shows the urgent need for torque density enhancement of brushless doubly-fed machines for electric vehicle/hybrid electric vehicle applications. Computer simulations...

  8. The patatin-like protein from the latex of Hevea brasiliensis (Hev b 7) is not a vacuolar protein

    NARCIS (Netherlands)

    Jekel, PA; Hofsteenge, J; Beintema, JJ

    Upon centrifugation, rubber latex is divided into a layer of rubber particles, the cytosol, and the lutoid-body fraction, which is of vacuolar origin. One of the proteins isolated from the lutoid-body fraction is a protein with a molecular mass of 43 kDa, which has esterase activity on

  9. Single-Electrical-Port Control of Cascaded Doubly-Fed Induction Machine for EV/HEV Applications

    DEFF Research Database (Denmark)

    Han, Peng; Cheng, Ming; Chen, Zhe

    2017-01-01

    A single-electrical-port control scheme, for four-quadrant operation of cascaded doubly-fed induction machine (CDFIM), which has long been conceived as a motor or generator only suitable for limited two-quadrant operation, is proposed and theoretically demonstrated. The drive system is configured...... as slave inverter. With this configuration, the control emphasis is placed on the slave inverter, yielding reduced control complexity and cost, and the inaccuracy of flux estimation in conventional FOC for singly-fed induction machines is avoided at very low or even zero speed. It is found that the doubly...

  10. A Novel Method for Inverter Faults Detection and Diagnosis in PMSM Drives of HEVs based on Discrete Wavelet Transform

    Directory of Open Access Journals (Sweden)

    AKTAS, M.

    2012-11-01

    Full Text Available The paper proposes a novel method, based on wavelet decomposition, for detection and diagnosis of faults (switch short-circuits and switch open-circuits in the driving systems with Field Oriented Controlled Permanent Magnet Synchro?nous Motors (PMSM of Hybrid Electric Vehicles. The fault behaviour of the analyzed system was simulated by Matlab/SIMULINK R2010a. The stator currents during transients were analysed up to the sixth level detail wavelet decomposition by Symlet2 wavelet. The results prove that the proposed fault diagnosis system have very good capabilities.

  11. Optimal design and allocation of electrified vehicles and dedicated charging infrastructure for minimum life cycle greenhouse gas emissions and cost

    International Nuclear Information System (INIS)

    Traut, Elizabeth; Hendrickson, Chris; Klampfl, Erica; Liu, Yimin; Michalek, Jeremy J.

    2012-01-01

    Electrified vehicles can reduce greenhouse gas (GHG) emissions by shifting energy demand from gasoline to electricity. GHG reduction potential depends on vehicle design, adoption, driving and charging patterns, charging infrastructure, and electricity generation mix. We construct an optimization model to study these factors by determining optimal design of conventional vehicles, hybrid electric vehicles (HEVs), plug-in hybrid electric vehicles (PHEVs), and battery electric vehicles (BEVs) with optimal allocation of vehicle designs and dedicated workplace charging infrastructure in the fleet for minimum life cycle cost or GHG emissions over a range of scenarios. We focus on vehicles with similar body size and acceleration to a Toyota Prius under government 5-cycle driving conditions. We find that under the current US grid mix, PHEVs offer only small GHG emissions reductions compared to HEVs, and workplace charging is insignificant. With grid decarbonization, PHEVs and BEVs offer substantial GHG emissions reductions, and workplace charging provides additional benefits. HEVs are optimal or near-optimal for minimum cost in most scenarios. High gas prices and low vehicle and battery costs are the major drivers for PHEVs and BEVs to enter and dominate the cost-optimal fleet. Carbon prices have little effect. Cost and range restrictions limit penetration of BEVs. - Highlights: ► We pose an MINLP model to minimize cost and GHG emissions of electrified vehicles. ► We design PHEVs and BEVs and assign vehicles and charging infrastructure in US fleet. ► Under US grid mix, PEVs provide minor GHG reductions and work chargers do little. ► HEVs are robust; PEVs and work charging potential improve with a decarbonized grid. ► We quantify factors needed for PEVs to enter and dominate the optimal fleet.

  12. Performance Evaluation of Lower-Energy Energy Storage Alternatives for Full-Hybrid Vehicles; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Gonder, J.; Cosgrove, J.; Pesaran, A.

    2014-02-11

    Automakers have been mass producing hybrid electric vehicles (HEVs) for well over a decade, and the technology has proven to be very effective at reducing per-vehicle fuel use. However, the incremental cost of HEVs such as the Toyota Prius or Ford Fusion Hybrid remains several thousand dollars higher than the cost of comparable conventional vehicles, which has limited HEV market penetration. The b b b b battery energy storage device is typically the component with the greatest contribution toward this cost increment, so significant cost reductions/performance improvements to the energy storage system (ESS) can correspondingly improve the vehicle-level cost/benefit relationship. Such an improvement would in turn lead to larger HEV market penetration and greater aggregate fuel savings. The United States Advanced Battery Consortium (USABC) and the U.S. Department of Energy (DOE) Energy Storage Program managers asked the National Renewable Energy Laboratory (NREL) to collaborate with a USABC Workgroup and analyze the trade-offs between vehicle fuel economy and reducing the decade-old minimum energy requirement for power-assist HEVs. NREL’s analysis showed that significant fuel savings could still be delivered from an ESS with much lower energy storage than the previous targets, which prompted USABC to issue a new set of lower-energy ESS (LEESS) targets that could be satisfied by a variety of technologies. With support from DOE, NREL has developed an HEV test platform for in-vehicle performance and fuel economy validation testing of the hybrid system using such LEESS devices. This presentation describes development of the vehicle test platform, and laboratory as well as in-vehicle evaluation results with alternate energy storage configurations as compared to the production battery system. The alternate energy storage technologies considered include lithium-ion capacitors -- i.e., asymmetric electrochemical energy storage devices possessing one electrode with battery

  13. 76 FR 72442 - Certain Automotive GPS Navigation Systems, Components Thereof, and Products Containing Same...

    Science.gov (United States)

    2011-11-23

    ...; Toyota Motor Corporation, 1 Toyota-cho, Toyota City, Aichi Prefecture 471-8571, Japan; Toyota Motor North America, Inc., 19001 S. Western Avenue, Torrance, CA 90501; Toyota Motor Sales, U.S.A., Inc., 19001 S. Western Avenue, Torrance, CA 90501; Toyota Motor Engineering & Manufacturing North America, Inc., 25...

  14. Pengaruh Komunikasi Pemasaran Terhadap Ekuitas Merek (Studi Pada Konsumen Mobil Toyota Avanza Tahun 2012 Di Auto 2000 Malang Cabang Sukun)

    OpenAIRE

    Wicaksono, Agung

    2014-01-01

    This study aims to find out how the marketing communications together or separately, and to tell the influential variables are dominant in the brand equity. As for the independent variables used in this study are of Advertising, Customer Relations and Personal Selling. Dependent variable used in this study is Brand Equity. Of research in this study was the explanatory research, which used research instruments in the form of a questionnaire that is disseminated to the 92 respondents who are co...

  15. The new TOYOTA 4.8L V10 petrol high performance engine for LEXUS LFA super car

    Energy Technology Data Exchange (ETDEWEB)

    Okamoto, Takamitsu; Kawamura, Hiroshi; Tsukamoto, Keisuke; Nagai, Masakatsu; Uchida, Takahiro [Toyota Motor Corporation (Japan); Maruyama, Heiji [Yamaha Motor Corporation (Japan)

    2011-07-01

    The new 1LR-GUE V10 high performance engine was designed exclusively for the Lexus LFA super car (below picture). Achieving the speed and performance of a true super car was merely the starting point. The engine was developed to create a feeling of infinite acceleration potential. Response is instant and based on close understanding of driver's reactions. Vehicle handling provides unsurpassed response and feedback with ideal transient torque characteristics and marvelous sound with unique design. The performance of this engine was accomplished by combining world-class high revolution speed and high power (per liter). The new 4.8L engine produces 412kW (560hp) at 8700rpm and redline is 9000rpm (fuel cut-off speed is 9500rpm). It meets the latest emission standard Euro V and achieves good fuel consumption with a wide range stoechiometric air fuel ratio, till speeds up to 240km/h. (orig.)

  16. 丰田发动机装配线精益设计%Perfect Design of Toyota Engine Assembly Line

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    一汽丰田(长春)发动机有限公司是一汽与丰田合资成立的公司,产品是3.0L和2.5L的V6发动机,其组装线完全按照丰田理念建造,丰田公司每新建一条组装线首先要考虑如下要求。

  17. The Applications of Toyota Production System to Reduce Wastes in Agricultural Products Packing Process: A Study of Onion Packing Plant

    OpenAIRE

    Paisarn Larpsomboonchai

    2015-01-01

    Agro-industry is one of major industries that have strong impacts on national economic incomes, growth, stability, and sustainable development. Moreover, this industry also has strong influences on social, cultural and political issues. Furthermore, this industry, as producing primary and secondary products, is facing challenges from such diverse factors such as demand inconsistency, intense international competition, technological advancements and new competitors. In ord...

  18. Sinkronisasi Waktu Kerja antara Operator Supply Part dan Mainline di Unit Produksi PT.TMMIN (Toyota Motor Manufacturing Indonesia

    Directory of Open Access Journals (Sweden)

    Ellisa Kusuma Dewi

    2013-03-01

    Full Text Available Dalam dunia manufaktur waktu line stop adalah masalah yang besar karena akan mengganggu kapasitas produksi. Data waktu line stop yang disebabkan oleh keterlambatan operator pada bulan April - October 2012 menampilkan bahwa 51.39% terjadi di area supply part. Masalah ini terjadi karena belum ada SOP yang mengatur antara supply part dengan mainline dalam hal pengiriman small part, dan tidak ada visualisasi waktu kerja operator supply part yang sinkron dengan operator mainline. Solusi yang ditawarkan adalah dengan menyinkronisasi waktu kerja antara operator supply part dan mainline, dengan cara menambahkan sinyal informasi mengenai waktu kerja operator di area supply part dalam bentuk indikator lampu berbasis PLC. Informasi ini berupa sinyal waktu kerja operator yaitu :start cycle, working process, middle cycle, warning start dan line stop. Setelah adanya penambahan sinyal informasi untuk operator supply part, sinkronisasi waktu kerja operator berhasil dilakukan sesuai standar kerja operator dan sinkron dengan waktu kerja operator mainline yaitu selama 88 detik.Waktu line stop dalam dua bulan terakhir berkurang sebesar 1080 detik dan 1170 detik.

  19. Pengaruh Social Media Marketing melalui Blackberry Messenger terhadap Minat Beli Konsumen di PT Agung Automall (Agung Toyota) Harapan Raya Pekanbaru

    OpenAIRE

    Lubis, Evawani Elysa; Pratama, Lian

    2016-01-01

    The rise of social media is the new media can be used as marketing at once to do consumer interaction, called social media marketing. One of the social media marketing which is now popular among business people, IE blackberry messenger. Through this application can send a message text, sound, and images for free about their business or place information and promotions offered from their products so that it formed an interest to buy from someone, with the blackberry messenger messages or infor...

  20. A Comparative Analysis of the Internationalisation Strategy of Chinese and Japanese Firms---The Case of Geely and Toyota

    OpenAIRE

    Jiang, Wenwen

    2012-01-01

    In a long period of time, internationalisation has been related to MNEs from developed markets. For instance, after the World War II, the development of Japanese MNEs should be regarded as a “miracle”. Recently, the internationalisation of enterprises from emerging markets is on the rise. Considering the growth of Chinese MNEs, the development path after economic reforms in 1978 is similar to that of Japanese MNEs since World War II. As more Chinese enterprises start to be engaged in internat...

  1. Analisis Pengaruh Ekuitas Merek Terhadap Keputusan Pembelian Mobil Toyota New Avanza (Studi Kasus Pada Auto 2000 Sm. Raja Medan)

    OpenAIRE

    Lubis, Faisal Afif

    2015-01-01

    Brand equity consists of several elements, such as brand awareness is the ability of a potential buyer to recognize, recall a brand as part of a particular product category. The role of brand awareness in brand equity will depend on the level of achievement of awareness in the minds of consumers. Brand association impression that everything that comes to mind someone associated with his memory about a brand. The impression that the quality of the overall customer perception of quality or exce...

  2. 76 FR 66750 - Certain Automotive GPS Navigation Systems, Components Thereof, and Products Containing Same...

    Science.gov (United States)

    2011-10-27

    ... Kingdom; Land Rover of United Kingdom; Toyota Motor Corporation of Japan; Toyota Motor North America, Inc. of Torrance, CA; Toyota Motor Sales, U.S.A., Inc. of Torrance, CA; Toyota Motor Engineering & Manufacturing North America, Inc. of Erlanger, KY; Toyota Motor Manufacturing, Indiana, Inc. of Princeton, IN...

  3. Development of EV/HEV systems suitable for EMC supported by simulation; EMV-gerechte Entwicklung von Elektro- und Hybridfahrzeugen mit Simulationsunterstuetzung

    Energy Technology Data Exchange (ETDEWEB)

    Reindl, Hartwig; Hansen, Heiko [AVL-Trimerics, Regensburg (Germany). Bereich EMV

    2011-07-15

    EMC requirements regarding emission and immunity valid for systems are also valid for all involved system components. To ensure electro-magnetic compatibility AVL-Trimerics follows a systematically approach. (orig.)

  4. Optimal Rule-Based Power Management for Online, Real-Time Applications in HEVs with Multiple Sources and Objectives: A Review

    Directory of Open Access Journals (Sweden)

    Bedatri Moulik

    2015-08-01

    Full Text Available The field of hybrid vehicles has undergone intensive research and development, primarily due to the increasing concern of depleting resources and increasing pollution. In order to investigate further options to optimize the performance of hybrid vehicles with regards to different criteria, such as fuel economy, battery aging, etc., a detailed state-of-the-art review is presented in this contribution. Different power management and optimization techniques are discussed focusing on rule-based power management and multi-objective optimization techniques. The extent of rule-based power management and optimization in solving battery aging issues is investigated along with an implementation in real-time driving scenarios where no pre-defined drive cycle is followed. The goal of this paper is to illustrate the significance and applications of rule-based power management optimization based on previous contributions.

  5. ESTABLISHING SUSTAINABLE US HEV/PHEV MANUFACTURING BASE: STABILIZED LITHIUM METAL POWDER, ENABLING MATERIAL AND REVOLUTIONARY TECHNOLOGY FOR HIGH ENERGY LI-ION BATTERIES

    Energy Technology Data Exchange (ETDEWEB)

    Yakovleva, Marina

    2012-12-31

    FMC Lithium Division has successfully completed the project “Establishing Sustainable US PHEV/EV Manufacturing Base: Stabilized Lithium Metal Powder, Enabling Material and Revolutionary Technology for High Energy Li-ion Batteries”. The project included design, acquisition and process development for the production scale units to 1) produce stabilized lithium dispersions in oil medium, 2) to produce dry stabilized lithium metal powders, 3) to evaluate, design and acquire pilot-scale unit for alternative production technology to further decrease the cost, and 4) to demonstrate concepts for integrating SLMP technology into the Li- ion batteries to increase energy density. It is very difficult to satisfy safety, cost and performance requirements for the PHEV and EV applications. As the initial step in SLMP Technology introduction, industry can use commercially available LiMn2O4 or LiFePO4, for example, that are the only proven safer and cheaper lithium providing cathodes available on the market. Unfortunately, these cathodes alone are inferior to the energy density of the conventional LiCoO2 cathode and, even when paired with the advanced anode materials, such as silicon composite material, the resulting cell will still not meet the energy density requirements. We have demonstrated, however, if SLMP Technology is used to compensate for the irreversible capacity in the anode, the efficiency of the cathode utilization will be improved and the cost of the cell, based on the materials, will decrease.

  6. Occupant kinematics of the Hybrid III, THOR-M, and postmortem human surrogates under various restraint conditions in full-scale frontal sled tests.

    Science.gov (United States)

    Albert, Devon L; Beeman, Stephanie M; Kemper, Andrew R

    2018-02-28

    The objective of this research was to compare the occupant kinematics of the Hybrid III (HIII), THOR-M, and postmortem human surrogates (PMHS) during full-scale frontal sled tests under 3 safety restraint conditions: knee bolster (KB), knee bolster and steering wheel airbag (KB/SWAB), and knee bolster airbag and steering wheel airbag (KBAB/SWAB). A total of 20 frontal sled tests were performed with at least 2 tests performed per restraint condition per surrogate. The tests were designed to match the 2012 Toyota Camry New Car Assessment Program (NCAP) full-scale crash test. Rigid polyurethane foam surrogates with compressive strength ratings of 65 and 19 psi were used to simulate the KB and KBAB, respectively. The excursions of the head, shoulders, hips, knees, and ankles were collected using motion capture. Linear acceleration and angular velocity data were also collected from the head, thorax, and pelvis of each surrogate. Time histories were compared between surrogates and restraint conditions using ISO/TS 18571. All surrogates showed some degree of sensitivity to changes in restraint condition. For example, the use of a KBAB decreased the pelvis accelerations and the forward excursions of the knees and hips for all surrogates. However, these trends were not observed for the thorax, shoulders, and head, which showed more sensitivity to the presence of a SWAB. The average scores computed using ISO/TS 18571 for the HIII/PMHS and THOR-M/PMHS comparisons were 0.527 and 0.518, respectively. The HIII had slightly higher scores than the THOR-M for the excursions (HIII average = 0.574; THOR average = 0.520). However, the THOR-M had slightly higher scores for the accelerations and angular rates (HIII average = 0.471; THOR average = 0.516). The data from the current study showed that both KBABs and SWABs affected the kinematics of all surrogates during frontal sled tests. The results of the objective rating analysis indicated that the HIII and THOR-M had comparable

  7. Assessing Rates of Global Warming Emissions from Port- Fuel Injection and Gasoline Direct Injection Engines in Light-Duty Passenger Vehicles

    Science.gov (United States)

    Short, D.; , D., Vi; Durbin, T.; Karavalakis, G.; Asa-Awuku, A. A.

    2013-12-01

    Passenger vehicles are known emitters of climate warming pollutants. CO2 from automobile emissions are an anthropogenic greenhouse gas (GHG) and a large contributor to global warming. Worldwide, CO2 emissions from passenger vehicles are responsible for 11% of the total CO2 emissions inventory. Black Carbon (BC), another common vehicular emission, may be the second largest contributor to global warming (after CO2). Currently, 52% of BC emissions in the U.S are from the transportation sector, with ~10% originating from passenger vehicles. The share of pollutants from passenger gasoline vehicles is becoming larger due to the reduction of BC from diesel vehicles. Currently, the majority of gasoline passenger vehicles in the United States have port- fuel injection (PFI) engines. Gasoline direct injection (GDI) engines have increased fuel economy compared to the PFI engine. GDI vehicles are predicted to dominate the U.S. passenger vehicle market in the coming years. The method of gasoline injection into the combustion chamber is the primary difference between these two technologies, which can significantly impact primary emissions from light-duty vehicles (LDV). Our study will measure LDV climate warming emissions and assess the impact on climate due to the change in U.S vehicle technologies. Vehicles were tested on a light- duty chassis dynamometer for emissions of CO2, methane (CH4), and BC. These emissions were measured on F3ederal and California transient test cycles and at steady-state speeds. Vehicles used a gasoline blend of 10% by volume ethanol (E10). E10 fuel is now found in 95% of gasoline stations in the U.S. Data is presented from one GDI and one PFI vehicle. The 2012 Kia Optima utilizes GDI technology and has a large market share of the total GDI vehicles produced in the U.S. In addition, The 2012 Toyota Camry, equipped with a PFI engine, was the most popular vehicle model sold in the U.S. in 2012. Methane emissions were ~50% lower for the GDI technology

  8. Hepatitis E Virus

    African Journals Online (AJOL)

    Before the discovery of hepatitis E virus (HEV), many epidemics of hepatitis in ... HEV was discovered in 1983 in the ... HEV infection is increased by HIV infection in pregnancy. (Caron et al. .... immunosuppressive therapy on the natural history.

  9. Aasta lõpp kisub automüügis pingeliseks / Tõnu Tramm

    Index Scriptorium Estoniae

    Tramm, Tõnu, 1968-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti 15. dets. lk. 17. Aasta müüduimatest automarkidest. Tabelid: Toyota selja taga rebivad prantslased; Toyota Corolla novembri müüduim; Aasta kokkuvõttes Toyota edu mäekõrgune; Toyota Corolla edukaim kui Mazda6

  10. 76 FR 2598 - Final Theft Data; Motor Vehicle Theft Prevention Standard

    Science.gov (United States)

    2011-01-14

    ... the Toyota Matrix. NHTSA is correcting the final theft data to include the thefts and production volumes for the Toyota Matrix. As a result of this correction, the Toyota Matrix, previously not listed........... 219 99,176 2.2082 47 TOYOTA COROLLA 374 170,360 2.1954 48 AUDI AUDI S6 2 928 2.1552 49 GENERAL MOTORS...

  11. 78 FR 51381 - Early Warning Reporting, Foreign Defect Reporting, and Motor Vehicle and Equipment Recall...

    Science.gov (United States)

    2013-08-20

    ... Toyota Motor North America, Inc. (Toyota). The specific comments of each entity will be discussed below... Toyota commented specifically on the proposal to amend Sec. 579.21(b) and (c) to require light vehicle.... Toyota indicated that they could determine the vehicle type from vehicle model; while Ford indicated that...

  12. 78 FR 68748 - Federal Motor Vehicle Safety Standards; Designated Seating Positions

    Science.gov (United States)

    2013-11-15

    ... Justice (AAJ), Safety Research and Strategies (SRS), Toyota Motor North America (Toyota), Mitsubishi Motors R&D of America (Mitsubishi), and Public Citizen.\\2\\ Toyota also expressed its support for the Alliance's petition. The petitions filed by SAE International and Toyota were styled both as requests for...

  13. 77 FR 29247 - Federal Motor Vehicle Safety Standards; Occupant Crash Protection

    Science.gov (United States)

    2012-05-17

    ...). On January 25, 2005, we received a request for interpretation from Toyota Motor North America, Inc. (Toyota) concerning S4.5.1(e).\\5\\ Toyota's concern was that S4.5.1(e)(1) makes an exception for S4.5.1(e... vehicles certified to meet certain advanced air bag requirements on or after December 1, 2003. Toyota...

  14. The District Capital, City of Toyota : experiments of advanced transportation information, park and ride at events, shared use of low emission vehicles

    Science.gov (United States)

    2000-11-09

    On Thursday, November 9, 2000, the Benefits, Evaluation and Costs (BEC) Committee of ITS America hosted a workshop entitled International Workshop on ITS Benefits: How Evaluation Results Are Used in Transportation Decision-Making in Turin, Ital...

  15. Technologies of TOYOTA Forklifts%先进的技术卓越的品质--走近丰田叉车系列报道之二

    Institute of Scientific and Technical Information of China (English)

    陈方建

    2004-01-01

    @@ 经过几天与丰田叉车的零距离接触,记者眼中的丰田叉车一步步地清晰起来,也慢慢明白了为什么它能在世界市场上取得如此骄人的业绩!因为丰田自主开发的多种先进技术,成就了丰田叉车无比卓越的品质.

  16. Trouble removal of throttle sensor in Toyota Crown.%丰田皇冠轿车节气门位置传感器的故障排除

    Institute of Scientific and Technical Information of China (English)

    张海山; 李占民

    2001-01-01

    @@一辆丰田皇冠CROWN轿车,装用2JZ-GE型发动机,发动机怠速不稳,转速时高时低,经反复调整也不见好转。另外,汽车在40 km/h速度段行驶时,经常出现窜动现象。   

  17. 丰田发动机空燃比传感器工作解析%Analysis of the Toyota engine air-fuel ratio sensor work

    Institute of Scientific and Technical Information of China (English)

    覃国金

    2010-01-01

    文章介绍了丰田系列发动机采用的线性型空燃比传感器的结构和工作原理,该类型传感器是目前电控发动机采用的新技术之一,希望对行业相关技术人员给予借鉴和帮助.

  18. Toyota Corolla sedan difficulty steering failure analysis%丰田卡罗拉轿车转向困难故障分析

    Institute of Scientific and Technical Information of China (English)

    罗锡亮

    2014-01-01

    本文主要介绍一部2012款卡罗拉电动转向系统(EPS)的构造,工作原理,分析该车出现转向困难,组合仪表上P/S警告灯亮起故障的原因,并提出解决故障的方法。%This paper describes a 2012 Corolla electric power steering system (EPS) of the structure, working principle, analyze the car steering difficulties arise, the combination meter P/S warning light on the reasons for failure and propose solutions to the fault.

  19. Failure Diagnosis Methods for TOYOTA A650E Automatic Transmission%丰田A650自动变速器故障诊断方法

    Institute of Scientific and Technical Information of China (English)

    胡宁; 吴训成; 陈志恒

    2005-01-01

    A650E型自动变速器是具有420N.m传矩能力的五挡自动变速器.论述了该自动变速器故障及诊断方法.介绍了排除一辆装备A650E自动变速器的凌志(LExUS)GS300轿车冷车行驶基本正常、热车起步困难的故障实例.

  20. Study on the TOYOTA Hybrid Power System with the ADVISOR%应用ADVISOR研究丰田混合动力系统

    Institute of Scientific and Technical Information of China (English)

    史广奎

    2003-01-01

    研究了丰田混合动力系统及其主要控制策略,利用ADVISOR软件对Prius轿车的加速过程和燃油经济性进行了模拟计算,并与试验结果进行了对比.UDDS工况下计算的油耗为4.88~5.65 L/100 km,EPA的试验结果为4.85 L/100 km;HWFET工况下计算的油耗为3.35~4.28 L/100 km,EPA的试验结果为4.37 L/100 km.

  1. The Influence of the Product, the Price and Promotion of the Decision of the Purchase of Toyota Avanza on PT Nasmoco Gombel Semarang

    OpenAIRE

    Rathomy, Evan; Rodhiyah, Rodhiyah; Listyorini, Sari

    2016-01-01

    Decision making consumers involves the intergration combining knowledge to evaluate two or more alternative behavior and choose the one of them. Many factors that must be considered in the decision to buy a product for consideration in decision making. Departing from consideration of for decision purchase, few customers choose car products other similar since goods was more offer design for affordable more dynamic and abreast of developments. This means that declining sales Avanza at PT. Toyo...

  2. "The Strategic Effects of Firm Sizes and Dynamic Capabilities on Overseas Operations: A Case-based Comparison of Toyota and Mitsubishi in Thailand and Australia" (in Japanese)

    OpenAIRE

    Takahiro Fujimoto; Shinya Orihashi

    2002-01-01

    In international business, much attention has been directed to the international expansion of firms based on their use of resources and competitive capabilities that have been built up in a home country to create a competitive advantage over host-country firms. More recently, the organizational capabilities and competitive advantages of Japanese manufacturing firms in general (in autos, electronics, etc.) have been analyzed as important factors in the establishment of overseas transplants. Th...

  3. "The Strategic Effects of Firm Sizes and Dynamic Capabilities on Overseas Operations: A Case-based Comparison of Toyota and Mitsubishi in Thailand and Australia"

    OpenAIRE

    Takahiro Fujimoto; Shinya Orihashi

    2002-01-01

    In international business, much attention has been directed to the international expansion of firms based on their use of resources and competitive capabilities that have been built up in a home country to create a competitive advantage over host-country firms. More recently, the organizational capabilities and competitive advantages of Japanese manufacturing firms in general (in autos, electronics, etc.) have been analyzed as important factors in the establishment of overseas transplants. Th...

  4. Analisis Strategi Menghadapi Persaingan Dalam Meningkatkan Volume Penjualan Mobil Toyota Avanza Pada PT Astra Internasional AUTO 2000 Cabang Gatot Subroto Medan

    OpenAIRE

    Simanungkalit, Meilinda

    2011-01-01

    Tujuan penelitian adalah untuk mengetahui dan menganalisis strategi persaingan dalam meningkatkan volume penjualan pada PT Astra Internasional AUTO 2000 cabang Gatot Subroto Medan. Kesimpulan yang diperoleh penulis berdasarkan hasil dari penelitian yang dilakukan dengan menggunakan Matriks SWOT, yaitu dengan strategi SO, WO, ST, WT, dengan strategi persaingan yang dilakukan oleh PT Astra Internasional AUTO 2000 sudah cukup baik. Akan tetapi PT Astra Internasional lebih menggunakan strategi ya...

  5. The Impact of Ninomiya Sontoku's Ideology of Hotoku on Toyota's Corporate Culture——Based on Toyota Five Main Principles%二宫尊德报德思想对丰田企业文化的影响——基于《丰田纲领》

    Institute of Scientific and Technical Information of China (English)

    左汉卿

    2013-01-01

    《丰田纲领》所体现的“报德思想”是集团创始人丰田佐吉人生价值观的根本,也是奠定丰田企业文化根基的思想基础.丰田佐吉“劳动、感谢、奉献”的人生理念,以及奠定丰田企业文化根基的核心理念,都来自日本江户时代农政思想家二官尊德“报德思想”中的“勤劳、至诚、分度、推让”理念.

  6. Prevalence of hepatitis E virus infection in liver transplant recipients

    NARCIS (Netherlands)

    Haagsma, Elizabeth B; Niesters, Hubert G M; van den Berg, Arie P; Riezebos-Brilman, Annelies; Porte, Robert J; Vennema, Harry; Reimerink, Johan H J; Koopmans, Marion P G

    2009-01-01

    Hepatitis E virus (HEV) infection is known to run a self-limited course. Recently, chronic hepatitis E has been described in several immunosuppressed patients after solid organ transplantation. The prevalence of HEV infection after transplantation, however, is unknown. We studied HEV parameters [HEV

  7. Hepatitis E Virus Genotype 3 in Humans and Swine, Bolivia

    Science.gov (United States)

    Cavallo, Annalisa; Gonzales, José Luis; Bonelli, Sara Irene; Valda, Ybar; Pieri, Angela; Segundo, Higinio; Ibañez, Ramón; Mantella, Antonia; Bartalesi, Filippo; Tolari, Francesco; Bartoloni, Alessandro

    2011-01-01

    We determined the seroprevalence of hepatitis E virus (HEV) in persons in 2 rural communities in southeastern Bolivia and the presence of HEV in human and swine fecal samples. HEV seroprevalence was 6.3%, and HEV genotype 3 strains with high sequence homology were detected. PMID:21801630

  8. Serological evidence of hepatitis E virus infection in pigs and jaundice among pig handlers in Bangladesh

    DEFF Research Database (Denmark)

    Haider, Najmul; Khan, M. S. U.; Hossain, M. B.

    2017-01-01

    Hepatitis E virus (HEV) is the most common cause of viral hepatitis in humans. Pigs may act as a reservoir of HEV, and pig handlers were frequently identified with a higher prevalence of antibodies to HEV. The objectives of this study were to identify evidence of HEV infection in pigs and compare...

  9. Hepatitis E Virus Variant in Farmed Mink, Denmark

    DEFF Research Database (Denmark)

    Krog, Jesper Schak; Breum, Solvej Østergaard; Jensen, Trine Hammer

    2013-01-01

    Hepatitis E virus (HEV) is a zoonotic virus for which pigs are the primary animal reservoir. To investigate whether HEV occurs in mink in Denmark, we screened feces and tissues from domestic and wild mink. Our finding of a novel HEV variant supports previous findings of HEV variants in a variety...

  10. High concentrations of natural rubber latex allergens in gloves used ...

    African Journals Online (AJOL)

    Introduction. Gloves made of natural rubber latex (NRL) are commonly used by healthcare workers because of their good qualities. However, allergic reactions to latex allergens are still commonly reported. Objective. To measure the concentrations of Hev b 1, Hev b 3, Hev b 5 and Hev b 6.02 allergens in gloves used by a ...

  11. State Constrained Optimal Control Applied to Supervisory Control in HEVs Commande optimale avec restrictions d’états appliquée à la supervision de l’énergie de véhicules hybrides

    Directory of Open Access Journals (Sweden)

    Pérez L.V.

    2010-02-01

    Full Text Available The optimization of the supervisory control of hybrid electric vehicles over predetermined driving cycles has been used as a previous study for determining on-line strategies and also for design and sizing purposes. This problem may be posed as an optimal control problem, in which the energy in the bank of batteries is often the state variable, and the power from any of the system sources is, the control action. As both of these quantities are bounded, the optimal control problem has control constraints or state constraints or both. Usually, the charge-sustaining mode of operation is ensured just by imposing a transversality condition, i.e. a fixed final energy, or including an additional term in the cost functional that penalizes the moving away of the state variable from the nominal value. We considered the problem where the state is allowed to move freely within a band. This led to an optimal control problem with control and state constraints. In this work we describe the difficulties that arise while solving the equations given by the Pontryagin’s Maximum Principle and how these difficulties can be overcome by using the so-called Direct Transcription approach that consists of a programming tool to solve the resultant large-scale finite dimensional optimization problem. L’optimisation de la commande au niveau superviseur de véhicules hybrides sur cycles d’usage prédéterminés a été utilisée comme une première étude pour déterminer des stratégies en ligne mais aussi avec des objectifs de conception et dimensionnement. Ce problème peut être posé comme un problème de commande optimale, où l’énergie dans les batteries est généralement la variable d’état et où la puissance de n’importe quelle source du système est l’action de commande. Comme ces deux quantités sont bornées, le problème de commande optimale a des restrictions sur la fonction de commande et sur l’état. Généralement, le fonctionnement à charge batterie constante est assuré juste en imposant une condition d’énergie finale fixée ou par l’introduction d’un terme additionnel dans la fonction coût qui pénalise les déviations de la variable d’état par rapport à sa valeur nominale. Par contre, nous avons considéré le cas où on permet que l’état varie librement à l’intérieur d’une plage. Ce cas conduit à un problème de commande optimale avec restrictions sur la fonction de commande et sur la variable d’état. Dans ce travail, nous décrivons les difficultés qui apparaissent quand on veut rechercher la solution des conditions d’optimalité données par le Principe du Maximum de Pontryagin et comment elles peuvent être résolues par l’utilisation de la technique appelée de Transcription Directe. Celle-ci consiste en la discrétisation dans le temps de toute la formulation du problème et en l’utilisation postérieure d’un outil de programmation non linéaire pour résoudre le problème d’optimisation à dimension finie et à grande échelle qui en résulte.

  12. 传统差速器应用于HEV动力耦合的可行性%Feasibility of applying traditional differential into HEV as power-split device

    Institute of Scientific and Technical Information of China (English)

    于永涛; 王庆年; 曾小华; 王鹏宇

    2010-01-01

    为了给混联式混合动力汽车提供新型的动力耦合装置,同时突破Toyota汽车公司的THS动力耦合系统专利的限制、束缚,通过对传统锥齿轮差速器的结构及工作原理的研究与分析,并与日本Toyota公司Prius混合动力汽车的THS系统中的PSD(动力耦合装置)进行对比研究,得出传统的差速器可以作为混联混合动力汽车的动力耦合装置的可行性,同时,通过仿真对可行性的结论进行了验证.

  13. Detection of Genotype 4 Swine Hepatitis E Virus in Systemic Tissues in Cross-Species Infected Rabbits

    OpenAIRE

    Wu, Qiaoxing; An, Junqing; She, Ruiping; Shi, Ruihan; Hao, Wenzhuo; Soomro, MajidHussain; Yuan, Xuerui; Yang, Jinling; Wang, Jingyuan

    2017-01-01

    Increasing evidence demonstrates that hepatitis E virus (HEV) can be transmitted across species. According to previous reports, swine HEV has two genotypes, genotype 3 and 4, and both can infect humans by the fecal-oral route. Thus, it is crucial for the control of HEV zoonotic transmission to evaluate the dynamics of viral shedding and distribution in different tissues during cross-species infection by HEV. In this study, rabbits were infected with genotype 4 swine HEV by the intraperitoneal...

  14. Effect of Intake Air Filter Condition on Vehicle Fuel Economy

    Energy Technology Data Exchange (ETDEWEB)

    Norman, Kevin M [ORNL; Huff, Shean P [ORNL; West, Brian H [ORNL

    2009-02-01

    The U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy and the U.S. Environmental Protection Agency (EPA) jointly maintain a fuel economy website (www.fueleconomy.gov), which helps fulfill their responsibility under the Energy Policy Act of 1992 to provide accurate fuel economy information [in miles per gallon (mpg)] to consumers. The site provides information on EPA fuel economy ratings for passenger cars and light trucks from 1985 to the present and other relevant information related to energy use such as alternative fuels and driving and vehicle maintenance tips. In recent years, fluctuations in the price of crude oil and corresponding fluctuations in the price of gasoline and diesel fuels have renewed interest in vehicle fuel economy in the United States. (User sessions on the fuel economy website exceeded 20 million in 2008 compared to less than 5 million in 2004 and less than 1 million in 2001.) As a result of this renewed interest and the age of some of the references cited in the tips section of the website, DOE authorized the Oak Ridge National Laboratory (ORNL) Fuels, Engines, and Emissions Research Center (FEERC) to initiate studies to validate and improve these tips. This report documents a study aimed specifically at the effect of engine air filter condition on fuel economy. The goal of this study was to explore the effects of a clogged air filter on the fuel economy of vehicles operating over prescribed test cycles. Three newer vehicles (a 2007 Buick Lucerne, a 2006 Dodge Charger, and a 2003 Toyota Camry) and an older carbureted vehicle were tested. Results show that clogging the air filter has no significant effect on the fuel economy of the newer vehicles (all fuel injected with closed-loop control and one equipped with MDS). The engine control systems were able to maintain the desired AFR regardless of intake restrictions, and therefore fuel consumption was not increased. The carbureted engine did show a decrease in

  15. 77 FR 55267 - Decision That Certain Nonconforming Motor Vehicles Are Eligible for Importation

    Science.gov (United States)

    2012-09-07

    ...-2012-0035 Nonconforming Vehicles: 1999-2006 Toyota Land Cruiser IFS 100 Series Multipurpose Passenger... Toyota Land Cruiser IFS 100 Series Multipurpose Passenger Vehicles Manufactured prior to September 1...

  16. [Hepatitis E as zoonosis].

    Science.gov (United States)

    Baumann-Popczyk, Anna

    2011-01-01

    The hepatitis E virus (HEV) the causative agent of hepatitis E, is a non-enveloped RNA virus. HEV is transmitted through oral consumption of contaminated food and water According to the currently knowledge now be considered as zoonosis. The main reservoir of HEV are pigs, boars and deer. For the first time HEV was isolated from animals (pigs) in 1997 in the U.S. Genetic analysis of strains isolated from pigs showed high similarity to strains HEV isolated from humans. This was the first evidence showing that HEV is a zoonosis. Further studies have shown that occupational groups e.g. veterinarians, swine breeders with close contact to pigs have an increased risk for HEV infections. The additional evidence supported the zoonotic potential of HEV were reports of acute hepatitis E after the consumption of undercooked meat from deer and wild boar. Infection of HEV in the domestic pig and wild boar population in Europe is widespread.

  17. Detection and localization of rabbit hepatitis e virus and antigen in systemic tissues from experimentally intraperitoneally infected rabbits.

    Directory of Open Access Journals (Sweden)

    Jingjing Mao

    Full Text Available Rabbit hepatitis E virus (HEV is a novel genotype of HEV, and is considered to pose a risk of zoonotic transmission. Research into the systemic distribution of rabbit HEV in rabbits during different periods of infection has rarely been reported. To better understand this virus, we infected rabbits with second-passage rabbit HEV via an intraperitoneal route. After inoculation, the infection showed two types, temporary and constant infection. The detection of HEV RNA in the feces varied with time, and serum antigen correlated with fecal HEV RNA. Viremia only appeared 72 days after inoculation. The rabbits remained antibody negative throughout the experimental period. When HEV was localized, several organs besides the liver were HEV RNA positive. Tissue antigen was observed immunohistochemically in the different cells of various organs, especially in parts of the small intestine and the characteristic rabbit gut-associated lymphoid tissue. These data provide valuable information for future research into the pathogenesis of HEV.

  18. High prevalence of hepatitis E virus infection in goats.

    Science.gov (United States)

    Long, Feiyan; Yu, Wenhai; Yang, Chenchen; Wang, Jue; Li, Yunlong; Li, Yi; Huang, Fen

    2017-11-01

    Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide, primarily transmitted by fecal-oral route. Zoonotic transmission of HEV from HEV-infected pigs (pork) or cows (milk) to human or non-human primate has been confirmed, but the risk of HEV in goat is still rarely assessed. In the present study, stool, blood, tissues, and milk of goat were collected for HEV infection investigation from Dali City of Yunnan Province in China, where raw mutton and goat milk are traditionally consumed. Surprisingly, a high prevalence of HEV infection in goat was found. Phylogenetic analysis revealed that all HEV isolates from goat belong to genotype 4 and subtype 4h, and shared a high similarity homology (>99.6%) with HEV isolated from human, swine, and cows in the same area. Results suggested that goats are a previously unrecognized HEV host. © 2017 Wiley Periodicals, Inc.

  19. Energy Dependence: The $1.4 Trillion Addiction Threatening National Security

    Science.gov (United States)

    2010-02-01

    shared by executives from major automobile manufacturers to include General Motors, Honda, Nissan and Toyota .52 Toyota , for example, is currently leasing...going away. The vehicles and fuels people use to travel and move goods will have to change in order to solve the problem. 9 Figure 1: Toyota Motor...the viability of new automobile products. Toyota Motor Company and the DOE National Renewable Energy Lab (NREL), for example, used California to

  20. ME化と労資関係 : トヨタ自動車を事例として

    OpenAIRE

    猿田, 正機; Masaki, Saruta; 中京大学経営学部

    1992-01-01

    In recent years, the high competitiveness of Toyota in international markets has been attracting worldwide attention. It has generally been asserted that the main reasons for Toyota's success have been the just-in-time (JIT) system, small-group production, and worker diligence, but I consider that the key to understanding the secret of Toyota's high competitiveness is the labour-management relations factor. The features of Toyota's production system cited above-JIT, small-group activities, an...

  1. Autonomous and Connected Vehicles: A Law Enforcement Primer

    Science.gov (United States)

    2015-12-01

    parallel or back-in parking in Toyota Prius vehicles is one example currently marketed and in operation in the United States.275 Testing is on-going...ownership in a connected environment.276 275 “All-New Third Generation Toyota Prius Raises the Bar for...design-patterns-and- operational-concepts-tasks-28-42-115/. Toyota . “All-New Third Generation Toyota Prius Raises the Bar for Hybrid Vehicles— Again

  2. Molecular Biology and Infection of Hepatitis E Virus

    Directory of Open Access Journals (Sweden)

    Yuchen Nan

    2016-09-01

    Full Text Available Hepatitis E virus (HEV is a viral pathogen transmitted primarily via fecal-oral route. In humans, HEV mainly causes acute hepatitis and is responsible for large outbreaks of hepatitis across the world. The case fatality rate of HEV-induced hepatitis ranges from 0.5 to 3% in young adults and up to 30% in infected pregnant women. HEV strains infecting humans are classified into four genotypes. HEV strains from genotype 3 and 4 are zoonotic, whereas those from genotype 1 and 2 have no known animal reservoirs. Recently, notable progress has been accomplished for better understanding of HEV biology and infection, such as chronic HEV infection, in vitro cell culture system, quasi-enveloped HEV virions, functions of the HEV proteins, mechanism of HEV antagonizing host innate immunity, HEV pathogenesis and vaccine development. However, further investigation on the cross-species HEV infection, host tropism, vaccine efficacy and HEV-specific antiviral strategy is still needed. This review mainly focuses on molecular biology and infection of HEV and offers perspective new insight of this enigmatic virus.

  3. Vaccine Development against Zoonotic Hepatitis E Virus: Open Questions and Remaining Challenges

    Directory of Open Access Journals (Sweden)

    Yuchen Nan

    2018-02-01

    Full Text Available Hepatitis E virus (HEV is a fecal-orally transmitted foodborne viral pathogen that causes acute hepatitis in humans and is responsible for hepatitis E outbreaks worldwide. Since the discovery of HEV as a zoonotic agent, this virus has been isolated from a variety of hosts with an ever-expanding host range. Recently, a subunit HEV vaccine developed for the prevention of human disease was approved in China, but is not yet available to the rest of the world. Meanwhile, notable progress and knowledge has been made and revealed in recent years to better understand HEV biology and infection, including discoveries of quasi-enveloped HEV virions and of a new function of the HEV-ORF3 product. However, the impact of these new findings on the development of a protective vaccine against zoonotic HEV infection requires further discussion. In this review, hallmark characteristics of HEV zoonosis, the history of HEV vaccine development, and recent discoveries in HEV virology are described. Moreover, special attention is focused on quasi-enveloped HEV virions and the potential role of the HEV-ORF3 product as antibody-neutralization target on the surface of quasi-enveloped HEV virions to provide new insights for the future development of improved vaccines against zoonotic HEV infection.

  4. Vaccine Development against Zoonotic Hepatitis E Virus: Open Questions and Remaining Challenges

    Science.gov (United States)

    Nan, Yuchen; Wu, Chunyan; Zhao, Qin; Sun, Yani; Zhang, Yan-Jin; Zhou, En-Min

    2018-01-01

    Hepatitis E virus (HEV) is a fecal-orally transmitted foodborne viral pathogen that causes acute hepatitis in humans and is responsible for hepatitis E outbreaks worldwide. Since the discovery of HEV as a zoonotic agent, this virus has been isolated from a variety of hosts with an ever-expanding host range. Recently, a subunit HEV vaccine developed for the prevention of human disease was approved in China, but is not yet available to the rest of the world. Meanwhile, notable progress and knowledge has been made and revealed in recent years to better understand HEV biology and infection, including discoveries of quasi-enveloped HEV virions and of a new function of the HEV-ORF3 product. However, the impact of these new findings on the development of a protective vaccine against zoonotic HEV infection requires further discussion. In this review, hallmark characteristics of HEV zoonosis, the history of HEV vaccine development, and recent discoveries in HEV virology are described. Moreover, special attention is focused on quasi-enveloped HEV virions and the potential role of the HEV-ORF3 product as antibody-neutralization target on the surface of quasi-enveloped HEV virions to provide new insights for the future development of improved vaccines against zoonotic HEV infection. PMID:29520257

  5. High prevalence of hepatitis e virus in Swedish moose--a phylogenetic characterization and comparison of the virus from different regions.

    Directory of Open Access Journals (Sweden)

    Jay Lin

    Full Text Available Hepatitis E virus (HEV infects a range of species, including humans, pigs, wild boars and deer. Zoonotic transmission may contribute to the high HEV seroprevalence in the human population of many countries. A novel divergent HEV from moose (Alces alces in Sweden was recently identified by partial genome sequencing. Since only one strain was found, its classification within the HEV family, prevalence in moose and zoonotic potential was unclear. We therefore investigated samples from 231 moose in seven Swedish counties for HEV, and sequenced a near complete moose HEV genome. Phylogenetic analysis to classify this virus within the family Hepeviridae and to explore potential host specific determinants was performed.The HEV prevalence of moose was determined by PCR (marker for active infection and serological assays (marker of past infection of sera and 51 fecal samples from 231 Swedish moose. Markers of active and past infection were found in 67 (29% animals, while 34 (15% were positive for HEV RNA, 43 (19% were seropositive for anti-HEV antibodies, and 10 (4% had both markers. The number of young individuals positive for HEV RNA was larger than for older individuals, and the number of anti-HEV antibody positive individuals increased with age. The high throughput sequenced moose HEV genome was 35-60% identical to existing HEVs. Partial ORF1 sequences from 13 moose strains showed high similarity among them, forming a distinct monophyletic clade with a common ancestor to HEV genotype 1-6 group, which includes members known for zoonotic transmission.This study demonstrates a high frequency of HEV in moose in Sweden, with markers of current and past infection demonstrated in 30% of the animals. Moose is thus an important animal reservoir of HEV. The phylogenetic relationship demonstrated that the moose HEV belonged to the genotype 1-6 group, which includes strains that also infect humans, and therefore may signify a potential for zoonotic transmission

  6. Salient Feature Identification and Analysis using Kernel-Based Classification Techniques for Synthetic Aperture Radar Automatic Target Recognition

    Science.gov (United States)

    2014-03-27

    22 2.2 Traditional backprojection image of Nissan Maxima . . . . . . . . . . . . . . . 23 2.3 SPLIT image output for Nissan Maxima...Toyota Tacoma . . . . . . . . . . . . . . . . . . . . . 27 2.6 SPLIT canonical shape histogram for Nissan Maxima . . . . . . . . . . . . . . 28 2.7 SPLIT...1999) SUV Nissan Maxima Sedan Mazda MPV SUV Mitsubishi Sedan Nissan Sentra Sedan Toyota Avalon Sedan Toyota Tacoma SUV is developed for distinguishing

  7. 77 FR 19155 - Federal Motor Vehicle Safety Standards; Seat Belt Assembly Anchorages; Incorporation by Reference

    Science.gov (United States)

    2012-03-30

    ... LeSabre, MY 2002 Toyota MR-2, MY 1995 Plymouth Neon, MY 1995 Toyota Previa, MY 2000 Chevrolet S-10, MY... FAD2 2005 VW Passat Pass Pass. 2005 Acura RL Pass Pass. 2005 Toyota Avalon Pass Pass. 2005 Buick... levels of government.'' NHTSA rules can preempt in two ways. First, the National Traffic and Motor...

  8. 76 FR 48009 - Federal Motor Vehicle Safety Standards; Lamps, Reflective Devices, and Associated Equipment

    Science.gov (United States)

    2011-08-08

    ... (AAM), Ford Motor Company (Ford), Nissan North America (Nissan), Toyota Motor North America (Toyota... ``* * * of multiple compartment lamps or * * *''. Toyota requested that paragraph S14.3.1 be modified to use... photometric requirements of DRLs. Valeo claimed that there is no way to reconcile Table 1 of SAE J222 (DEC...

  9. 78 FR 2111 - California State Motor Vehicle Pollution Control Standards; Notice of Decision Granting a Waiver...

    Science.gov (United States)

    2013-01-09

    ... complimentary in the way they address interrelated ambient air quality needs and climate change. EPA has...-0562-0349. EPA also received written comment from Toyota Motor North America (Toyota) at EPA-HQ-OAR-2012-0562- 0372 which notes that ``Toyota could be forced to employ a variety of costly marketing...

  10. The promise of fuel cell-based automobiles

    Indian Academy of Sciences (India)

    Unknown

    hybrid system or with a fuel cell–supercapacitor hybrid system (figure 4). In a clear demonstration of its commitment to have fuel-cell cars in series production by 2004, .... Toyota plans to launch a commercial FCV in 2003. Exxon and Toyota are working together on technology to extract hydrogen from gasoline. Toyota keeps ...

  11. 75 FR 35123 - Notice of Buy America Waiver for Minivans and Minivan Chassis

    Science.gov (United States)

    2010-06-21

    ... change its final assembly location from the United States to Japan; and Toyota has not responded to public procurements.\\1\\ \\1\\ Contrary to Chrysler's assertion that Toyota has not responded to public procurements, in May 2010 FTA learned that Toyota may have certified compliance with the Buy America...

  12. 75 FR 11005 - Final Theft Data; Motor Vehicle Theft Prevention Standard

    Science.gov (United States)

    2010-03-10

    ...)....... 91 41867 2.1735 45 TOYOTA......... COROLLA 740 351414 2.1058 46 NISSAN......... INFINITI FX45... 18579 1.6147 70 NISSAN......... INFINITI M35/M45.... 48 30144 1.5924 71 TOYOTA......... YARIS 252 159292... QUATTRO/ 18 11660 1.5437 S6/S6 AVANT. 77 FORD MOTOR CO.. FIVE HUNDRED........ 94 61270 1.5342 78 TOYOTA...

  13. 76 FR 35176 - Operation of Radar Systems in the 76-77 GHz Band

    Science.gov (United States)

    2011-06-16

    ... petitions for rulemaking filed by Toyota Motor Corporation (``TMC'') and Era Systems Corporation (``Era... and the general public. This action is taken in response to petitions for rulemaking filed by Toyota... NRAO's concerns about possible interference, but note that the peak limit recommended by Toyota is...

  14. Improving vehicle dynamics and fuel economy with an E-four hybrid powertrain

    NARCIS (Netherlands)

    Serrarens, A.F.A.; Noben, P.F.M.; Nievelstein, M.M.J.; Besselink, I.J.M.; Pauwelussen, J.P.

    2004-01-01

    Toyota Motor Corporation developed the Toyota Hybrid System with CVT (THS-C) for the Toyota Estimaminivan. The THS-C is based on Toyota’s Super CVT (K110), where the conventional torque converter is replaced by a torsional damper and a newly developed motor/generator. For smooth switching between

  15. 75 FR 28656 - New United Motor Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation, and...

    Science.gov (United States)

    2010-05-21

    ... Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation, and Toyota Motor Corporation, Including On- Site Leased Workers From Corestaff, ABM Janitorial, and Toyota Engineering and Manufacturing... joint venture of General Motors Corporation and Toyota Motor Corporation, including on-site leased...

  16. 75 FR 62424 - New United Motor Manufacturing, Inc. Formerly a Joint Venture of General Motors Corporation and...

    Science.gov (United States)

    2010-10-08

    ... Manufacturing, Inc. Formerly a Joint Venture of General Motors Corporation and Toyota Motor Corporation Including On- Site Leased Workers From Corestaff, ABM Janitorial, Toyota Engineering and Manufacturing North... Manufacturing, Inc., formerly a joint venture of General Motors Corporation and Toyota Motor Corporation...

  17. 75 FR 39045 - New United Motor Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation and...

    Science.gov (United States)

    2010-07-07

    ... Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation and Toyota Motor Corporation, Including On- Site Leased Workers From Corestaff, ABM Janitorial, Toyota Engineering and Manufacturing North... Corporation and Toyota Motor Corporation, including on-site leased workers from Corestaff, ABM Janitorial, and...

  18. 75 FR 47632 - New United Motor Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation and...

    Science.gov (United States)

    2010-08-06

    ... Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation and Toyota Motor Corporation, Including On- Site Leased Workers From Corestaff, ABM Janitorial, Toyota Engineering and Manufacturing North... of General Motors Corporation and Toyota Motor Corporation, including on-site leased workers from...

  19. 75 FR 26794 - New United Motor Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation and...

    Science.gov (United States)

    2010-05-12

    ... Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation and Toyota Motor Corporation... United Motor Manufacturing, Inc., formerly a joint venture of General Motors Corporation and Toyota Motor... reviewed the certification for workers of the subject firm. The workers assemble the Toyota Corolla and the...

  20. 76 FR 51120 - Denial of Motor Vehicle Defect Petition

    Science.gov (United States)

    2011-08-17

    ... investigation into the ``air bag systems failure'' that they experienced in their model year (MY) 2008 Toyota... investigation of MY 2008 Toyota Corolla vehicles is unlikely to result in a determination that a safety-related... allege that the frontal air bags in their Toyota Corolla failed to deploy during a crash into a deer...

  1. 76 FR 10396 - New United Motor Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation and...

    Science.gov (United States)

    2011-02-24

    ... Manufacturing, Inc., Formerly a Joint Venture of General Motors Corporation and Toyota Motor Corporation, Including On- Site Leased Workers From Corestaff, ABM Janitorial, Toyota Engineering and Manufacturing North... Motor Manufacturing, Inc., formerly a joint venture of General Motors Corporation and Toyota Motor...

  2. An epidemiological survey of hepatitis E virus in Shika deer, Cervus nippon, in Nara Park, Japan

    OpenAIRE

    萩原, 克郎; 辻, 正義; 川渕, 貴子; 鳥居, 春己; 小林, 朋子; 浅川, 満彦; 石原, 智明

    2008-01-01

    Hepatitis E Virus (HEV) infections have been reported in deer as well as in domestic animals; however, the precise epidemiological information regarding HEV infections in the Shika Deer in Nara Park in Japan remains to be investigated. In this study, we examined the anti-HEV antibodies and HEV-RNA in sera from 173 of female sika deer in the park. The reactivity to HEV antigen in the serum samples were low levels. The detection of HEV-RNA in sera from the deer revealed no positive samples by R...

  3. Low transfusion transmission of hepatitis E among 25,637 single-donation, nucleic acid-tested blood donors

    DEFF Research Database (Denmark)

    Harritshøj, Lene H.; Holm, Dorte K.; Sækmose, Susanne G.

    2016-01-01

    nucleic acid test with a 95% detection probability of 7.9 IU/mL. HEV-positive samples were quantified by real-time polymerase chain reaction and genotyped. Transmission was evaluated among recipients of HEV RNA-positive blood components. Phylogenetic analyses compared HEV sequences from blood donors......, symptomatic patients, and swine. RESULTS: Eleven donations (0.04%) were confirmed as positive for HEV RNA (median HEV RNA level, 13 IU/mL). Two donations were successfully genotyped as HEV-gt-3. Only one donor had a travel history outside Europe. Nine of 11 donors were male, but the gender ratio...

  4. PLUG-IN HYBRID ELECTRIC VEHICLE AND HYBRID ELECTRIC VEHICLE EMISSIONS UNDER FTP AND US06 CYCLES AT HIGH, AMBIENT, AND LOW TEMPERATURES

    Energy Technology Data Exchange (ETDEWEB)

    Seidman, M.R.; Markel, T.

    2008-01-01

    The concept of a Plug-in Hybrid Electric Vehicle (PHEV) is to displace consumption of gasoline by using electricity from the vehicle’s large battery pack to power the vehicle as much as possible with minimal engine operation. This paper assesses the PHEV emissions and operation. Currently, testing of vehicle emissions is done using the federal standard FTP4 cycle on a dynamometer at ambient (75°F) temperatures. Research was also completed using the US06 cycle. Furthermore, research was completed at high (95°F) and low (20°F) temperatures. Initial dynamometer testing was performed on a stock Toyota Prius under the standard FTP4 cycle, and the more demanding US06 cycle. Each cycle was run at 95°F, 75°F, and 20°F. The testing was repeated with the same Prius retrofi tted with an EnergyCS Plug-in Hybrid Electric system. The results of the testing confi rm that the stock Prius meets Super-Ultra Low Emission Vehicle requirements under current testing procedures, while the PHEV Prius under current testing procedures were greater than Super-Ultra Low Emission Vehicle requirements, but still met Ultra Low Emission Vehicle requirements. Research points to the catalyst temperature being a critical factor in meeting emission requirements. Initial engine emissions pass through with minimal conversion until the catalyst is heated to typical operating temperatures of 300–400°C. PHEVs also have trouble maintaining the minimum catalyst temperature throughout the entire test because the engine is turned off when the battery can support the load. It has been observed in both HEVs and PHEVs that the catalyst is intermittently unable to reduce nitrogen oxide emissions, which causes further emission releases. Research needs to be done to combat the initial emission spikes caused by a cold catalyst. Research also needs to be done to improve the reduction of nitrogen oxides by the catalyst system.

  5. Design, analysis and modeling of a novel hybrid powertrain system based on hybridized automated manual transmission

    Science.gov (United States)

    Wu, Guang; Dong, Zuomin

    2017-09-01

    Hybrid electric vehicles are widely accepted as a promising short to mid-term technical solution due to noticeably improved efficiency and lower emissions at competitive costs. In recent years, various hybrid powertrain systems were proposed and implemented based on different types of conventional transmission. Power-split system, including Toyota Hybrid System and Ford Hybrid System, are well-known examples. However, their relatively low torque capacity, and the drive of alternative and more advanced designs encouraged other innovative hybrid system designs. In this work, a new type of hybrid powertrain system based hybridized automated manual transmission (HAMT) is proposed. By using the concept of torque gap filler (TGF), this new hybrid powertrain type has the potential to overcome issue of torque gap during gearshift. The HAMT design (patent pending) is described in details, from gear layout and design of gear ratios (EV mode and HEV mode) to torque paths at different gears. As an analytical tool, mutli-body model of vehicle equipped with this HAMT was built to analyze powertrain dynamics at various steady and transient modes. A gearshift was decomposed and analyzed based basic modes. Furthermore, a Simulink-SimDriveline hybrid vehicle model was built for the new transmission, driveline and vehicle modular. Control strategy has also been built to harmonically coordinate different powertrain components to realize TGF function. A vehicle launch simulation test has been completed under 30% of accelerator pedal position to reveal details during gearshift. Simulation results showed that this HAMT can eliminate most torque gap that has been persistent issue of traditional AMT, improving both drivability and performance. This work demonstrated a new type of transmission that features high torque capacity, high efficiency and improved drivability.

  6. AN ASSESSMENT OF FLYWHEEL HIGH POWER ENERGY STORAGE TECHNOLOGY FOR HYBRID VEHICLES

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, James Gerald [ORNL

    2012-02-01

    An assessment has been conducted for the DOE Vehicle Technologies Program to determine the state of the art of advanced flywheel high power energy storage systems to meet hybrid vehicle needs for high power energy storage and energy/power management. Flywheel systems can be implemented with either an electrical or a mechanical powertrain. The assessment elaborates upon flywheel rotor design issues of stress, materials and aspect ratio. Twelve organizations that produce flywheel systems submitted specifications for flywheel energy storage systems to meet minimum energy and power requirements for both light-duty and heavy-duty hybrid applications of interest to DOE. The most extensive experience operating flywheel high power energy storage systems in heavy-duty and light-duty hybrid vehicles is in Europe. Recent advances in Europe in a number of vehicle racing venues and also in road car advanced evaluations are discussed. As a frame of reference, nominal weight and specific power for non-energy storage components of Toyota hybrid electric vehicles are summarized. The most effective utilization of flywheels is in providing high power while providing just enough energy storage to accomplish the power assist mission effectively. Flywheels are shown to meet or exceed the USABC power related goals (discharge power, regenerative power, specific power, power density, weight and volume) for HEV and EV batteries and ultracapacitors. The greatest technical challenge facing the developer of vehicular flywheel systems remains the issue of safety and containment. Flywheel safety issues must be addressed during the design and testing phases to ensure that production flywheel systems can be operated with adequately low risk.

  7. Cross-species infection of specific-pathogen-free pigs by a genotype 4 strain of human hepatitis E virus

    Science.gov (United States)

    Feagins, A. R.; Opriessnig, T.; Huang, Y. W.; Halbur, P. G.; Meng, X. J.

    2010-01-01

    SUMMARY Hepatitis E virus (HEV) is an important pathogen. The animal strain of HEV, swine HEV, is related to human HEV. The genotype 3 swine HEV infected humans and genotype 3 human HEV infected pigs. The genotype 4 swine and human HEV strains are genetically related, but it is unknown whether genotype 4 human HEV can infect pigs. A swine bioassay was utilized in this study to determine whether genotype 4 human HEV can infect pigs. Fifteen, 4-week-old, specific-pathogen-free pigs were divided into 3 groups of 5 each. Group 1 pigs were each inoculated intravenously with PBS buffer as negative controls, group 2 pigs similarly with genotype 3 human HEV (strain US-2), and group 3 pigs similarly with genotype 4 human HEV (strain TW6196E). Serum and fecal samples were collected at 0, 7, 14, 21, 28, 35, 42, 49, and 56 days postinoculation (dpi) and tested for evidence of HEV infection. All pigs were necropsied at 56 dpi. As expected, the negative control pigs remained negative. The positive control pigs inoculated with genotype 3 human HEV all became infected as evidenced by detection of HEV antibodies, viremia and fecal virus shedding. All five pigs in group 3 inoculated with genotype 4 human HEV also became infected: fecal virus shedding and viremia were detected variably from 7 to 56 dpi, and seroconversion occurred by 28 dpi. The data indicated that genotype 4 human HEV has an expanded host range, and the results have important implications for understanding the natural history and zoonosis of HEV. PMID:18551597

  8. Analisis Yuridis Terhadap Sengketa Kepemilikan Merek “Lexus” Antara Perusahaan PT. Toyota Jidosha Kabushiki Kaisha Dengan PT. Lexus Daya Utama (Studi Kasus Putusan No. 194.K/Pdt.Sus/2011)

    OpenAIRE

    Komalasari, Rini

    2016-01-01

    Brand is a mark which consists of pictures, names, words, alphabets, figures, color arrangement, of the combination of these elements which have distinctive power and are used in the activities of goods and services. The requirement/recognition on the right of brand for the brand ownership, according to constitution, is by registering it to the Directorate General of HKI as it is stipulated in Law on Brand No. 15/2001. This case began from the claim which was filed by PT. To...

  9. "TOYOTA",a Brand Forged for a Hundred Years%"丰田"--百年铸就的品牌--走近丰田叉车系列报道之一

    Institute of Scientific and Technical Information of China (English)

    陈方建; 郑朝霞

    2004-01-01

    @@ 应日本株式会社丰田自动织机、丰田产业车辆(上海)有限公司的邀请,记者随中国媒体代表团一行,于4月5日--9日在日本进行了为期5天的商务访问,亲临丰田集团日本总部参观考察,从而对丰田集团及丰田叉车有了更全面更深入地了解.

  10. On the Toyota LS400 Car Electronic Air Suspension System (TEMS)%浅谈丰田LS400轿车电子空气悬架系统(TEMS)

    Institute of Scientific and Technical Information of China (English)

    池杜旺

    2014-01-01

    随着汽车电子技术的不断发展以及人们对汽车舒适性的要求越来越高,一般的悬架系统已经很难满足高要求的现代车主们,而在如奥迪A8,奔驰S600,LS400等一些高档的轿车上面就采用了更为舒适,控制功能更强的电子悬架系统.

  11. 丰田皇冠3.0轿车怠速装置的检查与修理%Idle Speed Device and Maintenance of JAPAN TOYOTA CROWN 3.0 Carv

    Institute of Scientific and Technical Information of China (English)

    荆瑞山

    2000-01-01

    丰田皇冠3.0轿车装用2JZ-GE型发动机,采用的是多点电子控制燃油喷射系统.该系统主要由进气系统、供油系统、电子控制单元三部分组成.介绍了怠速装置的组成及工作原理;怠速转速的检查与调整及怠速混合气的调整.

  12. Hepatitis A and E virus infections among children in Mongolia.

    Science.gov (United States)

    Davaalkham, Dambadarjaa; Enkhoyun, Tsogzolbaatar; Takahashi, Masaharu; Nakamura, Yosikazu; Okamoto, Hiroaki

    2009-08-01

    To compare the epidemiologic profiles of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections in children in Mongolia, the prevalence of HAV and HEV infections was studied serologically and molecularly among 520 apparently healthy children 7-12 years of age (mean +/- standard deviation, 8.5 +/- 0.8 years) using serum samples obtained in 2004. Total antibody against HAV (anti-HAV) was detected in 438 children (84.2%), whereas IgG antibody against HEV (anti-HEV IgG) was detected in only three subjects (0.6%). All three subjects with anti-HEV IgG were negative for anti-HEV IgM and HEV RNA. The presence of HAV RNA was tested in all 520 subjects, and one child (9-year-old girl) was found to have detectable HAV RNA (subgenotype IA). In conclusion, HEV infection was uncommon, but subclinical HAV infection was highly prevalent among children in Mongolia.

  13. Prevalence of Anti-Hepatitis E Virus Antibodies and First Detection of Hepatitis E Virus in Wild Boar in Slovenia.

    Science.gov (United States)

    Žele, Diana; Barry, Aline F; Hakze-van der Honing, Renate W; Vengušt, Gorazd; van der Poel, Wim H M

    2016-01-01

    Hepatitis E is an emerging zoonotic disease caused by hepatitis E virus (HEV). In this study, we investigated HEV presence in a wild boar (Sus scrofa) population of Slovenia. A total of 288 wild boar serum samples were collected throughout the country, and HEV infection was investigated by serology, using enzyme-linked immunosorbent assay (ELISA) and by HEV RNA detection using a real-time PCR assay. Antibodies against HEV were detected in 30.2% (87/288) of animals tested, whereas HEV RNA was detected in only one sample. This is the first evidence of HEV presence in the wild boar population in Slovenia, and these results suggest that these animals are part of the HEV epidemiological cycle in the country.

  14. Detection of bat hepatitis E virus RNA in microbats in Japan.

    Science.gov (United States)

    Kobayashi, Tomoya; Murakami, Shin; Yamamoto, Terumasa; Mineshita, Ko; Sakuyama, Muneki; Sasaki, Reiko; Maeda, Ken; Horimoto, Taisuke

    2018-05-29

    Several recent studies have reported that various bat species harbor bat hepatitis E viruses (BatHEV) belonging to the family Hepeviridae, which also contains human hepatitis E virus (HEV). The distribution and ecology of BatHEV are not well known. Here, we collected and screened 81 bat fecal samples from nine bat species in Japan to detect BatHEV RNA by RT-PCR using HEV-specific primers, and detected three positive samples. Sequence and phylogenetic analyses indicated that these three viruses were BatHEVs belonging to genus Orthohepevirus D like other BatHEV strains reported earlier in various countries. These data support the first detection of BatHEVs in Japanese microbats, indicating their wide geographical distribution among multiple bat species.

  15. Evaluation of an antigen-capture EIA for the diagnosis of hepatitis E virus infection.

    Science.gov (United States)

    Zhao, C; Geng, Y; Harrison, T J; Huang, W; Song, A; Wang, Y

    2015-11-01

    An enzyme immunoassay (EIA) has been developed for hepatitis E virus (HEV) antigen (HEV-Ag) detection and marketed in China. This study aimed to evaluate the sensitivity of the assay and assess the value of HEV-Ag detection in the diagnosis of HEV infection in comparison with HEV RNA detection. Using serial dilutions of a genotype 4 HEV strain, significant correlation was found between the EIA (S/CO) and HEV RNA (IU/mL) concentration in the range 10(3.5) to 10(0.5) IU/mL HEV RNA, the Pearson correlation coefficient r approached 0.97. The EIA detection limit was 54.6 IU/mL, compared to 24 IU/mL for HEV RNA using real-time RT-PCR. In clinical samples from hepatitis E patients, the HEV-Ag and HEV RNA positivity rates were 55.6% (65/117) and 60.7% (71/117) in sera and 76.7% (56/73) and 84.9% (62/73) in stools, and the concordance of these two markers was 77.8% in sera and 80.8% in stools. In serum samples, the HEV-Ag positivity rate and the concordance between HEV-Ag and HEV RNA were inversely proportional to the presence of anti-HEV antibody. The presence of anti-HEV IgG could reduce the S/CO of the HEV-Ag EIA. These results reveal a significant correlation between the detection of HEV-Ag and HEV RNA. The sensitivity of the HEV-Ag EIA was lower than real-time RT-PCR but could be higher than conventional nested RT-PCR. Therefore, the detection of HEV-Ag in serum and faeces is valuable for the diagnosis and prognosis of HEV infection in developing regions where real-time RT-PCR is not available. © 2015 John Wiley & Sons Ltd.

  16. Development and validation of a genotype 3 recombinant protein-based immunoassay for hepatitis E virus serology in swine

    Directory of Open Access Journals (Sweden)

    W.H.M. van der Poel

    2014-04-01

    Full Text Available Hepatitis E virus (HEV is classified within the family Hepeviridae, genus Hepevirus. HEV genotype 3 (Gt3 infections are endemic in pigs in Western Europe and in North and South America and cause zoonotic infections in humans. Several serological assays to detect HEV antibodies in pigs have been developed, at first mainly based on HEV genotype 1 (Gt1 antigens. To develop a sensitive HEV Gt3 ELISA, a recombinant baculovirus expression product of HEV Gt3 open reading frame-2 was produced and coated onto polystyrene ELISA plates. After incubation of porcine sera, bound HEV antibodies were detected with anti-porcine anti-IgG and anti-IgM conjugates. For primary estimation of sensitivity and specificity of the assay, sets of sera were used from pigs experimentally infected with HEV Gt3. For further validation of the assay and to set the cutoff value, a batch of 1100 pig sera was used. All pig sera were tested using the developed HEV Gt3 assay and two other serologic assays based on HEV Gt1 antigens. Since there is no gold standard available for HEV antibody testing, further validation and a definite setting of the cutoff of the developed HEV Gt3 assay were performed using a statistical approach based on Bayes' theorem. The developed and validated HEV antibody assay showed effective detection of HEV-specific antibodies. This assay can contribute to an improved detection of HEV antibodies and enable more reliable estimates of the prevalence of HEV Gt3 in swine in different regions.

  17. Media, Art and Politics: The Centenary of the First World War in Britain

    OpenAIRE

    Peter Goodwin

    2015-01-01

    Peter Goodwin takes a critical look at how the media and arts in Britain have responded to the centenary of the First World War. He asks what this tells us about popular consciousness and the mechanisms of bourgeois ideology in Britain in the second decade of the 21st century. This contribution is a podcast of a Communication and Media Researach Institute (CAMRI) seminar that took place on January 21, 2015, at the University of Westminster.

  18. Media, Art and Politics: The Centenary of the First World War in Britain

    Directory of Open Access Journals (Sweden)

    Peter Goodwin

    2015-01-01

    Full Text Available Peter Goodwin takes a critical look at how the media and arts in Britain have responded to the centenary of the First World War. He asks what this tells us about popular consciousness and the mechanisms of bourgeois ideology in Britain in the second decade of the 21st century. This contribution is a podcast of a Communication and Media Researach Institute (CAMRI seminar that took place on January 21, 2015, at the University of Westminster.

  19. Epidemiologic, clinical and laboratory aspects of hepatitis E

    Indian Academy of Sciences (India)

    HEV infection: Clinical features · Hepatitis virus superinfection · HEV and cirrhosis: methods · HEV superinfection in cirrhosis · Hepatitis E: host cell damage · Intracellular cytokine expression · Slide 34 · Cytokine-expressing CD4 cells (ORF2) · Cytokine-expressing CD8 cells (ORF2) · Cytokine-expressing CD4 cells (ORF3).

  20. Silent hepatitis E virus infection in Dutch blood donors, 2011 to 2012

    NARCIS (Netherlands)

    Slot, E.; Hogema, B. M.; Riezebos-Brilman, A.; Kok, T. M.; Molier, M.; Zaaijer, H. L.

    2013-01-01

    In Europe, the dynamics of endemic hepatitis E virus (HEV) infection remain enigmatic. We studied the presence of silent HEV infection among Dutch blood donors. Using donations collected throughout the Netherlands in 2011 and 2012, 40,176 donations were tested for HEV RNA in 459 pools of 48 or 480

  1. Technology and design of a transmission ECU; Technologie und Design einer Transmissions-ECU

    Energy Technology Data Exchange (ETDEWEB)

    Maier, Johann [AB Mikroelektronik GmbH, Salzburg (Austria); Stephan, Waldemar [Online Engineering GmbH, Dortmund (Germany)

    2010-07-01

    Rising raw materials and fuel prices have revived interest in electric-powered vehicles. Powertrain design will depend on the driving characteristics and vehicle type; various combinations of hybrid-specific components are available: start-stop, Mild HEV (Hybrid Electric Vehicle), HEV, Plug-in HEV, Range Extender Vehicle, battery-driven cars, and fel cell driven cars. (orig.)

  2. Hepatitis E virus infection and acute non-traumatic neurological injury: A prospective multicentre study

    NARCIS (Netherlands)

    Dalton, H.R.; Eijk, J.J.J. van; Cintas, P.; Madden, R.G.; Jones, C.; Webb, G.W.; Norton, B.; Pique, J.; Lutgens, S.; Devooght-Johnson, N.; Woolson, K.; Baker, J.; Saunders, M.; Househam, L.; Griffiths, J.; Abravanel, F.; Izopet, J.; Kamar, N.; Alfen, N. van; Engelen, B.G.M. van; Hunter, J.G.; Eijk, A.A. van der; Bendall, R.P.; McLean, B.N.; Jacobs, B.C.

    2017-01-01

    BACKGROUND & AIMS: Hepatitis E virus (HEV) has been associated with a number of neurological syndromes, but causality has not yet been established. The aim of this study was to explore the relationship between HEV and neurological illness by prospective HEV testing of patients presenting with acute

  3. Development and Validation of a Genotype 3 Recombinant Protein based Immunoassay for Hepatitis E Virus Serology in Swine

    NARCIS (Netherlands)

    Poel, van der W.H.M.; Pavio, N.; Goot, van der J.; Es, van M.; Martin, M.; Engel, B.

    2014-01-01

    Hepatitis E virus (HEV) is classified within the family Hepeviridae, genus Hepevirus. HEV genotype 3 (Gt3) infections are endemic in pigs in Western Europe and in North and South America and cause zoonotic infections in humans. Several serological assays to detect HEV antibodies in pigs have been

  4. Hepatitis E seroprevalence and related risk factors among seafood processing workers: a cross-sectional survey in Shandong Province, China

    Directory of Open Access Journals (Sweden)

    Weihong Cui

    2016-08-01

    Conclusions: There is a higher risk of HEV infection in those who have direct contact with raw seafood. This study will help identify the risk factors for HEV infection and provide guidance on controlling HEV infection in the seafood processing occupations.

  5. Prevalence of Anti-Hepatitis E Virus Antibodies and First Detection of Hepatitis E Virus in Wild Boar in Slovenia

    NARCIS (Netherlands)

    Žele, Diana; Fernandes Barry, Aline; Honing-Hakze, van der Renate; Vengušt, Gorazd; Poel, Van Der W.H.M.

    2016-01-01

    Hepatitis E is an emerging zoonotic disease caused by hepatitis E virus (HEV). In this study, we investigated HEV presence in a wild boar (Sus scrofa) population of Slovenia. A total of 288 wild boar serum samples were collected throughout the country, and HEV infection was investigated by

  6. Hepatitis E virus infections in pigs : transmission dynamics and human exposure

    NARCIS (Netherlands)

    Bouwknegt, M.

    2009-01-01

    In dit promotieonderzoek is de transmissie dynamiek van Hepatitis E virus (HEV) bij varkens onderzocht, alsmede de potentiële blootstelling van de Nederlandse bevolking aan HEV uit varkens. Om te onderzoeken of HEV spreidt onder varkens is een experiment opgezet bestaande uit 10 infectieketens. Elke

  7. Increased hepatitis E virus seroprevalence correlates with lower CD4+ cell counts in HIV-infected persons in Argentina

    NARCIS (Netherlands)

    J.D. Debes; Martínez Wassaf, M. (Maribel); Pisano, M.B. (María Belén); Isa, M.B. (María Beatriz); Lotto, M. (Martin); Marianelli, L.G. (Leonardo G.); Frassone, N. (Natalia); Ballari, E. (Estefania); Bohjanen, P.R. (Paul R.); B.E. Hansen (Bettina); Ré, V. (Viviana)

    2016-01-01

    textabstractHepatitis E virus (HEV) is a single-stranded RNA virus that can cause hepatitis in an epidemic fashion. HEV usually causes asymptomatic or limited acute infections in immunocompetent individuals, whereas in immunosuppressed individuals such as transplant recipients, HEV can cause chronic

  8. The added value of hepatitis E diagnostics in determining causes of hepatitis in routine diagnostic settings in the Netherlands

    NARCIS (Netherlands)

    Doting, M. H. E.; Weel, J.; Niesters, H. G. M.; Riezebos-Brilman, A.; Brandenburg, A.

    OBJECTIVES: Hepatitis E virus (HEV) genotype 3 is endemic in Europe and an underdiagnosed and emerging (public) health issue. In recent years commercial enzyme immunoassays (EIAs) that detect antibodies to HEV more adequately, became available. We investigated the added value of this HEV serology in

  9. Hepatitis E virus as a Cause of Acute Hepatitis in The Netherlands

    NARCIS (Netherlands)

    Tholen, Aletta T. R.; Schinkel, Janke; Molenkamp, Richard; Ang, C. Wim

    2016-01-01

    Recent studies indicate that 27% of Dutch blood donors have evidence of past infection with HEV. However, the low number of diagnosed HEV infections indicates either an asymptomatic course or under diagnosis. We investigated whether HEV is a cause of acute hepatitis in Dutch patients and which

  10. Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear.

    Science.gov (United States)

    Spahr, Carina; Ryll, René; Knauf-Witzens, Tobias; Vahlenkamp, Thomas W; Ulrich, Rainer G; Johne, Reimar

    2017-12-01

    Hepatitis E virus (HEV) is the causative agent of hepatitis E, an emerging infectious disease of humans. HEV infections have also been described in various animal species. Whereas domestic pigs and wild boars are well-known animal reservoirs for HEV, the knowledge on natural HEV infection in zoo animals is scarce so far. Here, we analysed 244 sera from 66 mammal species derived from three zoos in Germany using a commercial double antigen sandwich ELISA. HEV-specific antibodies were detected in 16 animal species, with the highest detection rates in suids (33.3%) and carnivores (27.0%). However, RNA of the human pathogenic HEV genotypes 1-4 was not detected in the serum samples from suids or carnivores. Using a broad spectrum RT-PCR, a ratHEV-related sequence was identified in a sample of a female Syrian brown bear (Ursus arctos syriacus). Subsequent serum samples within a period of five years confirmed a HEV seroconversion in this animal. No symptoms of hepatitis were recorded. In a follow-up investigation at the same location, closely related ratHEV sequences were identified in free-living Norway rats (Rattus norvegicus), whereas feeder rats (Rattus norvegicus forma domestica) were negative for HEV-specific antibodies and RNA. Therefore, a spillover infection of ratHEV from free-living Norway rats is most likely. The results indicate that a wide range of zoo animals can be naturally infected with HEV or HEV-related viruses. Their distinct role as possible reservoir animals for HEV and sources of HEV infection for humans and other animals remains to be investigated. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Hepatitis E virus seroepidemiology: a post-earthquake study among blood donors in Nepal

    Directory of Open Access Journals (Sweden)

    Ashish C. Shrestha

    2016-11-01

    Full Text Available Abstract Background As one of the causative agents of viral hepatitis, hepatitis E virus (HEV has gained public health attention globally. HEV epidemics occur in developing countries, associated with faecal contamination of water and poor sanitation. In industrialised nations, HEV infections are associated with travel to countries endemic for HEV, however, autochthonous infections, mainly through zoonotic transmission, are increasingly being reported. HEV can also be transmitted by blood transfusion. Nepal has experienced a number of HEV outbreaks, and recent earthquakes resulted in predictions raising the risk of an HEV outbreak to very high. This study aimed to measure HEV exposure in Nepalese blood donors after large earthquakes. Methods Samples (n = 1,845 were collected from blood donors from Kathmandu, Chitwan, Bhaktapur and Kavre. Demographic details, including age and sex along with possible risk factors associated with HEV exposure were collected via a study-specific questionnaire. Samples were tested for HEV IgM, IgG and antigen. The proportion of donors positive for HEV IgM or IgG was calculated overall, and for each of the variables studied. Chi square and regression analyses were performed to identify factors associated with HEV exposure. Results Of the donors residing in earthquake affected regions (Kathmandu, Bhaktapur and Kavre, 3.2% (54/1,686; 95% CI 2.7–4.0% were HEV IgM positive and two donors were positive for HEV antigen. Overall, 41.9% (773/1,845; 95% CI 39.7–44.2% of donors were HEV IgG positive, with regional variation observed. Higher HEV IgG and IgM prevalence was observed in donors who reported eating pork, likely an indicator of zoonotic transmission. Previous exposure to HEV in Nepalese blood donors is relatively high. Conclusion Detection of recent markers of HEV infection in healthy donors suggests recent asymptomatic HEV infection and therefore transfusion-transmission in vulnerable patients is a risk in

  12. Hepatitis E virus seroepidemiology: a post-earthquake study among blood donors in Nepal.

    Science.gov (United States)

    Shrestha, Ashish C; Flower, Robert L P; Seed, Clive R; Rajkarnikar, Manita; Shrestha, Shrawan K; Thapa, Uru; Hoad, Veronica C; Faddy, Helen M

    2016-11-25

    As one of the causative agents of viral hepatitis, hepatitis E virus (HEV) has gained public health attention globally. HEV epidemics occur in developing countries, associated with faecal contamination of water and poor sanitation. In industrialised nations, HEV infections are associated with travel to countries endemic for HEV, however, autochthonous infections, mainly through zoonotic transmission, are increasingly being reported. HEV can also be transmitted by blood transfusion. Nepal has experienced a number of HEV outbreaks, and recent earthquakes resulted in predictions raising the risk of an HEV outbreak to very high. This study aimed to measure HEV exposure in Nepalese blood donors after large earthquakes. Samples (n = 1,845) were collected from blood donors from Kathmandu, Chitwan, Bhaktapur and Kavre. Demographic details, including age and sex along with possible risk factors associated with HEV exposure were collected via a study-specific questionnaire. Samples were tested for HEV IgM, IgG and antigen. The proportion of donors positive for HEV IgM or IgG was calculated overall, and for each of the variables studied. Chi square and regression analyses were performed to identify factors associated with HEV exposure. Of the donors residing in earthquake affected regions (Kathmandu, Bhaktapur and Kavre), 3.2% (54/1,686; 95% CI 2.7-4.0%) were HEV IgM positive and two donors were positive for HEV antigen. Overall, 41.9% (773/1,845; 95% CI 39.7-44.2%) of donors were HEV IgG positive, with regional variation observed. Higher HEV IgG and IgM prevalence was observed in donors who reported eating pork, likely an indicator of zoonotic transmission. Previous exposure to HEV in Nepalese blood donors is relatively high. Detection of recent markers of HEV infection in healthy donors suggests recent asymptomatic HEV infection and therefore transfusion-transmission in vulnerable patients is a risk in Nepal. Surprisingly, this study did not provide evidence of a large

  13. Prevalence of Hepatitis E Virus in Populations of Wild Animals in Comparison with Animals Bred in Game Enclosures.

    Science.gov (United States)

    Kubankova, Monika; Kralik, Petr; Lamka, Jiri; Zakovcik, Vladimir; Dolanský, Marek; Vasickova, Petra

    2015-03-15

    Hepatitis E virus (HEV) is now accepted as a zoonotic virus, and domestic pigs, wild boars and deer are recognised as natural reservoirs of the pathogen. In this study, 762 animals (wild boars, fallow deer, red deer, sika deer, roe deer and mouflons) originating from the wild and from game enclosures were tested for the presence of HEV RNA by qRT-PCR. HEV RNA was detected in wild boars (96/450), red deer (2/169), roe deer (1/30) and mouflons (5/39). The sequence relationship between HEV isolates from wild boars and domestic pigs or humans indicate a circulation of HEV in the Czech Republic.

  14. Molecular characterization of hepatitis E virus in patients with acute hepatitis in Venezuela.

    Science.gov (United States)

    García, Cristina Gutiérrez; Sánchez, Doneyla; Villalba, Maria Caridad Montalvo; Pujol, Flor Helene; de Los Ángeles Rodríguez Lay, Licel; Pinto, Belquis; Chacón, Elsa Patricia; Guzmán, Maria Guadalupe

    2012-07-01

    Hepatitis E virus (HEV) causes a common infection in developing countries. HEV infection occurs as outbreaks, as sporadic clinical cases and as large epidemics in endemic areas. The objective of this study was to determine the presence of HEV infection in patients with clinical suspicion of hepatitis A virus (HAV) infection, referred to the Instituto Nacional de Higiene "Rafael Rangel" in Venezuela. Seventy-four sera were tested for anti-HAV and anti-HEV IgM antibodies. HEV-RNA was amplified from anti-HEV IgM positive sera using nested reverse transcription polymerase chain reaction for ORF1 (RNA dependent RNA polymerase region) and the amplicons sequenced for phylogenetic analysis. The frequency of anti-HEV IgM was 22/74 (30%) in the samples tested. Dual infection with HAV and HEV was found in 31% (12/39) of anti-HAV IgM positive patients. Viremia was detected in 3/22 (14%) of sera positive for anti-HEV IgM. Two HEV strains were classified as genotype 1 and one as genotype 3, which were closely related to Yam 67 (north of India) and US1 isolates from the USA, respectively. These findings suggest that HEV is an important cause of acute viral hepatitis in Venezuela as a single infection or co-infection with HAV, with high morbidity in children and young adults suggesting that this infection is endemic in Venezuela. Copyright © 2012 Wiley Periodicals, Inc.

  15. Latex allergy: new insights to explain different sensitization profiles in different risk groups.

    Science.gov (United States)

    Peixinho, C; Tavares-Ratado, P; Tomás, M R; Taborda-Barata, L; Tomaz, C T

    2008-07-01

    Differences in latex allergen sensitization profiles have been described between children subjected to repetitive surgical interventions and health care workers (HCW). 'Major' allergens for patients with spina bifida are Hev b 1, 3 and 7, while for HCW, 'major' allergens are Hev b 2, 5, 6.01 and 13. The reason for these differential sensitization profiles is currently unknown. To investigate latex allergen profiles on internal and external surfaces of natural rubber latex gloves. Eighty-two samples of commonly used surgical gloves (41 glove brands) were used for analysis. Specific allergen levels of Hev b 1, 3, 5 and 6.02 on both surfaces of the gloves were quantified using an enzyme immunometric assay, a FITkit (FIT Biotech, Tampere, Finland). Differences in allergen levels were observed between internal and external surfaces of all glove types. Concentrations of Hev b 1 and Hev b 3 were significantly higher on external surfaces, while internal surfaces had higher allergen levels of Hev b 5 and Hev b 6.02. Analysis of surgical and examination gloves, powdered and nonpowdered gloves also showed that the content of Hev b 5 and Hev b 6.02 was significantly higher on internal surfaces while that of Hev b 1 and Hev b 3 was higher on external surfaces. Our study showed different allergen profiles on internal and external surfaces of natural rubber latex gloves. These results may suggest a relationship between latex allergen localization and sensitization routes in different risk groups.

  16. Optimization of the elution buffer and concentration method for detecting hepatitis E virus in swine liver using a nested reverse transcription-polymerase chain reaction and real-time reverse transcription-polymerase chain reaction.

    Science.gov (United States)

    Son, Na Ry; Seo, Dong Joo; Lee, Min Hwa; Seo, Sheungwoo; Wang, Xiaoyu; Lee, Bog-Hieu; Lee, Jeong-Su; Joo, In-Sun; Hwang, In-Gyun; Choi, Changsun

    2014-09-01

    The aim of this study was to develop an optimal technique for detecting hepatitis E virus (HEV) in swine livers. Here, three elution buffers and two concentration methods were compared with respect to enhancing recovery of HEV from swine liver samples. Real-time reverse transcription-polymerase chain reaction (RT-PCR) and nested RT-PCR were performed to detect HEV RNA. When phosphate-buffered saline (PBS, pH 7.4) was used to concentrate HEV in swine liver samples using ultrafiltration, real-time RT-PCR detected HEV in 6 of the 26 samples. When threonine buffer was used to concentrate HEV using polyethylene glycol (PEG) precipitation and ultrafiltration, real-time RT-PCR detected HEV in 1 and 3 of the 26 samples, respectively. When glycine buffer was used to concentrate HEV using ultrafiltration and PEG precipitation, real-time RT-PCR detected HEV in 1 and 3 samples of the 26 samples, respectively. When nested RT-PCR was used to detect HEV, all samples tested negative regardless of the type of elution buffer or concentration method used. Therefore, the combination of real-time RT-PCR and ultrafiltration with PBS buffer was the most sensitive and reliable method for detecting HEV in swine livers. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Hepatitis E Virus Mutations: Functional and Clinical Relevance

    Directory of Open Access Journals (Sweden)

    Hoang van Tong

    2016-09-01

    Full Text Available Hepatitis E virus (HEV infection is a major cause of acute hepatitis and affects more than 20 million individuals, with three million symptomatic cases and 56,000 recognized HEV-related deaths worldwide. HEV is endemic in developing countries and is gaining importance in developed countries, due to increased number of autochthone cases. Although HEV replication is controlled by the host immune system, viral factors (especially specific viral genotypes and mutants can modulate HEV replication, infection and pathogenesis. Limited knowledge exists on the contribution of HEV genome variants towards pathogenesis, susceptibility and to therapeutic response. Nonsynonymous substitutions can modulate viral proteins structurally and thus dysregulate virus-host interactions. This review aims to compile knowledge and discuss recent advances on the casual role of HEV heterogeneity and its variants on viral morphogenesis, pathogenesis, clinical outcome and antiviral resistance.

  18. Hepatitis E-induced severe myositis.

    Science.gov (United States)

    Mengel, Annerose M; Stenzel, Werner; Meisel, Andreas; Büning, Carsten

    2016-02-01

    Hepatitis E virus (HEV) is endemic in Asian and African countries but is rarely reported in Western countries. Although there are some prominent neurological manifestations, HEV is rarely recognized by neurologists. This is a case report of myositis induced by HEV. We report the life-threatening case of a 57-year-old man with flaccid tetraparesis due to myositis, acute hepatitis, and renal failure caused by HEV infection. Muscle biopsy revealed scattered myofiber necrosis with a diffuse, mild lymphomonocytic infiltrate in the endomysium and perimysium. Because the patient suffered from an acute HEV infection with a rapidly progressive course of severe myopathy, we started ribavirin treatment. He recovered partially within 3 weeks and recovered fully within 6 months. This case highlights a neurological manifestation of endemic HEV infection with severe myositis in a patient with alcoholic chronic liver disease. Ribavirin treatment is effective in severe HEV infection and may also lead to rapid neurological recovery. © 2015 Wiley Periodicals, Inc.

  19. Declining prevalence of hepatitis E antibodies among Danish blood donors

    DEFF Research Database (Denmark)

    Holm, Dorte K; Moessner, Belinda K; Engle, Ronald E

    2015-01-01

    BACKGROUND: The increasing incidence of reported hepatitis E cases in Europe has focused attention on hepatitis E virus (HEV) and the risk of transfusion-transmitted hepatitis E. The aim of this study was to investigate the prevalence of antibodies to HEV (anti-HEV) among Danish blood donors...... in 2013 and to compare it to previous studies in Denmark. In addition we wanted to compare the relative reactivity of two different assays. STUDY DESIGN AND METHODS: Samples from 504 blood donors were collected and analyzed for anti-HEV with an in-house assay developed at the National Institutes of Health...... (NIH). In addition the samples were analyzed with the Wantai anti-HEV assay. Demographic information and possible HEV exposure was collected by self-administered questionnaire. RESULTS: Using the NIH assay the prevalence of anti-HEV among Danish blood donors was 10.7% and with the Wantai assay...

  20. Prevalence of antibody to hepatitis E virus among wild sika deer, Cervus nippon, in Japan.

    Science.gov (United States)

    Matsuura, Y; Suzuki, M; Yoshimatsu, K; Arikawa, J; Takashima, I; Yokoyama, M; Igota, H; Yamauchi, K; Ishida, S; Fukui, D; Bando, G; Kosuge, M; Tsunemitsu, H; Koshimoto, C; Sakae, K; Chikahira, M; Ogawa, S; Miyamura, T; Takeda, N; Li, T C

    2007-01-01

    We examined 976 sika deer serum samples, 159 liver tissue samples and 88 stool samples collected from 16 prefectures in Japan, and performed ELISA and RT-PCR assays to detect antibodies to HEV and HEV RNA, respectively. Although 25 (2.6%) of 976 samples were positive for anti-HEV IgG, the antibody titers were very low. The OD values ranged between 0.018 and 0.486, forming a single distribution rather than a bimodal distribution, suggesting that the antibody detected in this study was not induced by HEV infection, or that deer have low sensitivity to HEV. HEV RNA was not detected in these samples, also suggesting that deer may not play a role as an HEV reservoir.

  1. Non-travel related Hepatitis E virus genotype 3 infections in the Netherlands; A case series 2004 – 2006

    Directory of Open Access Journals (Sweden)

    Bosman Arnold

    2008-05-01

    Full Text Available Abstract Background Human hepatitis E virus (HEV infections are considered an emerging disease in industrialized countries. In the Netherlands, Hepatitis E virus (HEV infections have been associated with travel to high-endemic countries. Non-travel related HEV of genotype 3 has been diagnosed occasionally since 2000. A high homology of HEV from humans and pigs suggests zoonotic transmission but direct molecular and epidemiological links have yet to be established. We conducted a descriptive case series to generate hypotheses about possible risk factors for non-travel related HEV infections and to map the genetic diversity of HEV. Methods A case was defined as a person with HEV infection laboratory confirmed (positive HEV RT-PCR and/or HEV IgM after 1 January 2004, without travel to a high-endemic country three months prior to onset of illness. For virus identification 148 bp of ORF2 was sequenced and compared with HEV from humans and pigs. We interviewed cases face to face using a structured questionnaire and collected information on clinical and medical history, food preferences, animal and water contact. Results We interviewed 19 cases; 17 were male, median age 50 years (25–84 y, 12 lived in the North-East of the Netherlands and 11 had preexisting disease. Most common symptoms were dark urine (n = 16 and icterus (n = 15. Sixteen ate pork ≥ once/week and six owned dogs. Two cases had received blood transfusions in the incubation period. Seventeen cases were viremic (genotype 3 HEV, two had identical HEV sequences but no identified relation. For one case, HEV with identical sequence was identified from serum and surface water nearby his home. Conclusion The results show that the modes of transmission of genotype-3 HEV infections in the Netherlands remains to be resolved and that host susceptibility may play an important role in development of disease.

  2. Hepatitis E Virus: Time to Change the Textbooks.

    Science.gov (United States)

    Dalton, Harry R; Webb, Glynn W; Norton, Ben C; Woolson, Kathy L

    Until recently, hepatitis E virus (HEV) was thought not to occur in developed countries. It is now clear that locally acquired HEV is common in such settings. HEV infection acquired in these areas differs from that in developing countries in a number of important aspects: it is caused by genotype 3 (and 4 in China and Japan), it mainly affects middle-aged/elderly males and it is zoonotic with a porcine primary host. Pig herds worldwide are infected with HEV genotype 3 and HEV has been found in the human food chain in a number of developed countries. However, the route of transmission is not fully understood, since most cases are not obviously associated with pigs/pig products. HEV can be transmitted by blood transfusion and surprisingly high numbers of asymptomatic blood donors are viremic at the time of donation: Germany 1:1,200, Netherlands 1:2,671, England 1:2,848. Our understanding of the clinical phenotype of HEV infection in humans has undergone a sea-change in recent years. Previously, HEV was thought to cause only acute self-limiting hepatitis. However, HEV may cause persistent disease in the immunocompromised. Patients with chronic HEV infection have no symptoms, but some develop rapidly progressive liver cirrhosis. The full clinical spectrum of HEV is still emerging. HEV has important extra-hepatic manifestations, which deserve further investigation. For example, HEV can cause a wide range of neurological illness. In particular, very recent data suggest that Guillain-Barré syndrome and neuralgic amyotrophy are associated with locally acquired HEV in approximately 5 and 10% of the cases, respectively. © 2016 S. Karger AG, Basel.

  3. Hepatitis E virus co-infection in HIV-infected patients in Foggia and Naples in southern Italy.

    Science.gov (United States)

    Scotto, Gaetano; Grisorio, Benvenuto; Filippini, Pietro; Ferrara, Sergio; Massa, Salvatore; Bulla, Fabio; Martini, Salvatore; Filippini, Alberico; Tartaglia, Alessandra; Lo Muzio, Lorenzo; Fazio, Vincenzina

    2015-01-01

    Hepatitis E virus (HEV) infection represents an emerging infection in developed countries and is thought to be a zoonotic infection. It has recently been described as a new causative agent of acute and chronic hepatitis in immunosuppressed subjects, including HIV-infected patients. The aim of this study was to assess the sero-virological prevalence of HEV in HIV patients and in the general population as control group. A prospective and observational cohort study was carried out in two hospitals in southern Italy. The seroprevalence of HEV was determined in a cohort of 959 subjects, 509 (53%) of whom were HIV-positive patients and 450 were from the general population. Serum samples were tested for anti-HEV antibodies; repeatedly positive results were confirmed by a Western blot assay. In positive patients HEV RNA and genotypes were also determined. A total of 46 (4.8%) of the 959 serum samples examined were reactive to anti-HEV Ig and confirmed by Western blotting. The prevalence of HEV antibodies (IgG and/or IgM) was 2.7% in the control group and 6.7% in HIV-infected patients. Anti-HEV IgM was found in 6/46 (13.0%) of the anti-HEV Ig-positive serum samples, in 5/34 HIV patients and in 1/12 of the general population. No HIV-infected patient presented chronic hepatitis with HEV infection alone. This study indicates a higher circulation of HEV in HIV-infected patients, whereas a low prevalence of HEV antibodies in the general Italian population was shown. Chronic hepatitis with HEV alone was absent, while it was present in subjects with HIV-HEV, co-infected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV).

  4. Transmission of Hepatitis E Virus in Developing Countries

    Directory of Open Access Journals (Sweden)

    Mohammad S. Khuroo

    2016-09-01

    Full Text Available Hepatitis E virus (HEV, an RNA virus of the Hepeviridae family, has marked heterogeneity. While all five HEV genotypes can cause human infections, genotypes HEV-1 and -2 infect humans alone, genotypes HEV-3 and -4 primarily infect pigs, boars and deer, and genotype HEV-7 primarily infects dromedaries. The global distribution of HEV has distinct epidemiological patterns based on ecology and socioeconomic factors. In resource-poor countries, disease presents as large-scale waterborne epidemics, and few epidemics have spread through person-to-person contact; however, endemic diseases within these countries can potentially spread through person-to-person contact or fecally contaminated water and foods. Vertical transmission of HEV from infected mother to fetus causes high fetal and perinatal mortality. Other means of transmission, such as zoonotic transmission, can fluctuate depending upon the region and strain of the virus. For instance, zoonotic transmission can sometimes play an insignificant role in human infections, such as in India, where human and pig HEV infections are unrelated. However, recently China and Southeast Asia have experienced a zoonotic spread of HEV-4 from pigs to humans and this has become the dominant mode of transmission of hepatitis E in eastern China. Zoonotic HEV infections in humans occur by eating undercooked pig flesh, raw liver, and sausages; through vocational contact; or via pig slurry, which leads to environmental contamination of agricultural products and seafood. Lastly, blood transfusion-associated HEV infections occur in many countries and screening of donors for HEV RNA is currently under serious consideration. To summarize, HEV genotypes 1 and 2 cause epidemic and endemic diseases in resource poor countries, primarily spreading through contaminated drinking water. HEV genotypes 3 and 4 on the other hand, cause autochthonous infections in developed, and many developing countries, by means of a unique zoonotic

  5. High occurrence of hepatitis E virus in samples from wastewater treatment plants in Switzerland and comparison with other enteric viruses.

    Science.gov (United States)

    Masclaux, Frédéric G; Hotz, Philipp; Friedli, Drita; Savova-Bianchi, Dessislava; Oppliger, Anne

    2013-09-15

    Hepatitis E virus (HEV) is responsible for many enterically transmitted viral hepatitides around the world. It is currently one of the waterborne diseases of global concern. In industrialized countries, HEV appears to be more common than previously thought, even if it is rarely virulent. In Switzerland, seroprevalence studies revealed that HEV is endemic, but no information was available on its environmental spread. The aim of this study was to investigate -using qPCR- the occurrence and concentration of HEV and three other viruses (norovirus genogroup II, human adenovirus-40 and porcine adenovirus) in influents and effluents of 31 wastewater treatment plants (WWTPs) in Switzerland. Low concentrations of HEV were detected in 40 out of 124 WWTP influent samples, showing that HEV is commonly present in this region. The frequency of HEV occurrence was higher in summer than in winter. No HEV was detected in WWTP effluent samples, which indicates a low risk of environmental contamination. HEV occurrence and concentrations were lower than those of norovirus and adenovirus. The autochthonous HEV genotype 3 was found in all positive samples, but a strain of the non-endemic and highly pathogenic HEV genotype I was isolated in one sample, highlighting the possibility of environmental circulation of this genotype. A porcine fecal marker (porcine adenovirus) was not detected in HEV positive samples, indicating that swine are not the direct source of HEV present in wastewater. Further investigations will be necessary to determine the reservoirs and the routes of dissemination of HEV. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. Hepatitis E virus as a Cause of Acute Hepatitis in The Netherlands.

    Directory of Open Access Journals (Sweden)

    Aletta T R Tholen

    Full Text Available Recent studies indicate that 27% of Dutch blood donors have evidence of past infection with HEV. However, the low number of diagnosed HEV infections indicates either an asymptomatic course or under diagnosis.We investigated whether HEV is a cause of acute hepatitis in Dutch patients and which diagnostic modality (serology or PCR should be used for optimal detection.Serum samples were retrospectively selected from non-severely immuno-compromised patients from a university hospital population, suspected of having an infectious hepatitis. Criteria were: elevated alanine aminotransferase (ALT> 34 U/l and request for antibody testing for CMV, EBV or Hepatitis A (HAV.All samples were tested for HEV using ELISA and PCR. Ninety patients/sera were tested, of which 22% were HEV IgG positive. Only one serum was IgM positive. HEV PCR was positive in two patients: one patient was both HEV IgM and IgG positive, the other patient was only IgG positive. Both HEV RNA positive samples belonged to genotype 3. Evidence of recent infection with CMV, EBV and HAV was found in 13%, 10% and 3% respectively.Although our study is limited by small numbers, we conclude that HEV is a cause of acute hepatitis in hospital associated patients in The Netherlands. Moreover, in our study population the prevalence of acute HAV (3% was almost similar to acute HEV (2%. We propose to incorporate HEV testing in panels for acute infectious hepatitis. Negative results obtained for HEV IgM in a HEV PCR positive patient, indicates that antibody testing alone may not be sufficient and argues for PCR as a primary diagnostic tool in hospital associated patients. The high percentage of HEV IgG seropositivity confirms earlier epidemiological studies.

  7. Autonomous Intersection Management

    Science.gov (United States)

    2009-12-01

    detects that the driver is not slowing sufficiently fast. Jaguar, Honda, and BMW offer similar systems. Nissan and Toyota have recently begun offering...that the driver is not braking hard enough. Both Toyota and BMW are currently selling vehicles that can parallel park completely autonomously, even...other vehicles. The system was tested both in simulation and with a robotic vehicle. This work is sponsored by Toyota , who have also currently have an

  8. The Navy’s Superior Supplier Incentive Program: Analysis of Supplier Proposed Benefits

    Science.gov (United States)

    2015-12-01

    rather than “short-term, easy, expendable and replaceable sources of goods and services” (Carter & Choi, 2008, p. 2). Japanese automakers Toyota ...was the key element behind Toyota and Honda’s strategic successes. Under the supplier keiretsu, the automakers worked closely with the selected...suppliers to achieve mutually beneficial objectives. Toyota and Honda implemented the keiretsu model in their North American plants and achieved

  9. 76 FR 36486 - Preliminary Theft Data; Motor Vehicle Theft Prevention Standard

    Science.gov (United States)

    2011-06-22

    ... 10,189 2.1592 33 GENERAL MOTORS......... CHEVROLET HHR 172 80,781 2.1292 34 TOYOTA SCION TC 57 27,179... LINCOLN TOWN CAR....... 24 11,596 2.0697 38 TOYOTA AVALON 45 22,030 2.0427 39 NISSAN 350Z 1 503 1.9881 40....7898 48 GENERAL MOTORS......... CADILLAC CTS 91 50,926 1.7869 49 VOLVO S60 12 6,837 1.7552 50 TOYOTA...

  10. 75 FR 47720 - Final Theft Data; Motor Vehicle Theft Prevention Standard

    Science.gov (United States)

    2010-08-09

    ........... 223 99681 2.2371 43 MERCEDES-BENZ......... 220 (S-CLASS)........ 91 41867 2.1735 44 TOYOTA COROLLA 740... M35/M45..... 48 30144 1.5924 71 TOYOTA YARIS 252 159292 1.5820 72 HONDA ACCORD 664 421206 1.5764 73............ FIVE HUNDRED......... 94 61270 1.5342 78 TOYOTA AVALON 121 79137 1.5290 79 NISSAN MURANO 137 92516 1...

  11. 77 FR 47882 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

    Science.gov (United States)

    2012-08-10

    ...; Navistar, Inc., Melrose Park, IL; Tata Motors, Ltd., Mumbai, INDIA; Toyota Motor Corp., Shizuoka, JAPAN..., Inc., Torrance, CA; Isuzu Motors Limited, Fujisawa, JAPAN; Jacobs Vehicle Systems, Bloomfield, CT...

  12. Seroprevalence and Incidence of hepatitis E in blood donors in Upper Austria.

    Directory of Open Access Journals (Sweden)

    Carina Fischer

    Full Text Available In recent years various studies showed, that hepatitis E virus (HEV is a growing public health problem in many developed countries. Therefore, HEV infections might bear a transmission risk by blood transfusions. The clinical relevance still requires further investigations. The aim of this study was to provide an overview of acute HEV infections in Upper Austrian blood donors as well as a risk estimation of this transfusion-related infection.A total of 58,915 blood donors were tested for HEV RNA using a commercial HEV RT-PCR Kit. 7 of these donors (0.01% were PCR-positive with normal laboratory parameters in absence of clinical signs of hepatitis. Viral load determined by quantitative real-time PCR showed a HEV nucleic acid concentration of 2,217 293,635 IU/ml. At follow-up testing (2-11 weeks after donation all blood donors had negative HEV RNA results. Additionally, genotyping was performed by amplification and sequencing of the ORF1 or ORF2 region of the HEV genome. All HEV RNA positive donor samples revealed a genotype 3 isolate. For the antibody screening, anti-HEV IgM and IgG were detected by ELISA. Follow up serological testing revealed that no donor was seropositive for HEV IgM or IgG antibodies at time of donation. Moreover, we verified the prevalence of anti-HEV IgG in 1,203 of the HEV RNA negative tested blood donors. Overall 13.55% showed positive results for anti-HEV IgG.In the presented study, we investigated HEV infections in blood donations of Upper Austria over 1 year. We concluded that 1 out of 8,416 blood donations is HEV RNA positive. Seroprevalence of anti HEV IgG results in an age-related increase of 13.55%. Therefore, based on this data, we recommend HEV-PCR screening to prevent transmission of hepatitis E virus by transfusion.

  13. Serological evidence of hepatitis E virus infection in pigs and jaundice among pig handlers in Bangladesh.

    Science.gov (United States)

    Haider, N; Khan, M S U; Hossain, M B; Sazzad, H M S; Rahman, M Z; Ahmed, F; Zeidner, N S

    2017-11-01

    Hepatitis E virus (HEV) is the most common cause of viral hepatitis in humans. Pigs may act as a reservoir of HEV, and pig handlers were frequently identified with a higher prevalence of antibodies to HEV. The objectives of this study were to identify evidence of HEV infection in pigs and compare the history of jaundice between pig handlers and people not exposed to pigs and pork. Blood and faecal samples were collected from 100 pigs derived from three slaughterhouses in the Gazipur district of Bangladesh from January to June, 2011. We also interviewed 200 pig handlers and 250 non-exposed people who did not eat pork or handled pigs in the past 2 years. We tested the pig sera for HEV-specific antibodies using a competitive ELISA and pig faecal samples for HEV RNA using real-time RT-PCR. Of 100 pig sera, 82% (n = 82) had detectable antibody against HEV. Of the 200 pig handlers, 28% (56/200) demonstrated jaundice within the past 2 years, whereas only 17% (43/250) of controls had a history of jaundice (p Bangladesh demonstrated evidence of HEV infection, and a history of jaundice was significantly more frequent in pig handlers. Identifying and genotyping HEV in pigs and pig handlers may provide further evidence of the pig's role in zoonotic HEV transmission in Bangladesh. © 2017 Blackwell Verlag GmbH.

  14. Energy conversion efficiency of hybrid electric heavy-duty vehicles operating according to diverse drive cycles

    Energy Technology Data Exchange (ETDEWEB)

    Banjac, Titina [AVL-AST d.o.o., Trg Leona Stuklja 5, SI-2000 Maribor (Slovenia); Trenc, Ferdinand; Katrasnik, Tomaz [Faculty of Mechanical Engineering, Univ. of Ljubljana, Askerceva 6, SI-1000 Ljubljana (Slovenia)

    2009-12-15

    Energy consumption and exhaust emissions of hybrid electric vehicles (HEVs) strongly depend on the HEV topology, power ratios of their components and applied control strategy. Combined analytical and simulation approach was applied to analyze energy conversion efficiency of different HEV topologies. Analytical approach is based on the energy balance equations and considers all energy paths in the HEVs from the energy sources to the wheels and to other energy sinks. Simulation approach is based on a fast forward-facing simulation model for simulating parallel and series HEVs as well as for conventional internal combustion engine vehicles, and considers all components relevant for modeling energy conversion phenomena. Combined approach enables evaluation of energy losses on different energy paths and provides their impact on the fuel economy. It therefore enables identification of most suitable HEV topology and of most suitable power ratios of the components for targeted vehicle application, since it reveals and quantifies the mechanisms that could lead to improved energy conversion efficiency of particular HEV. The paper exposes characteristics of the test cycles that lead to improved energy conversion efficiency of HEVs. Mechanisms leading to improved fuel economy of parallel HEVs through drive-away and vehicle propulsion at low powertrain loads by electric motor are also analyzed. It was also shown that control strategies managing energy flow through electric storage devices significantly influence energy conversion efficiency of series HEVs. (author)

  15. Acute Hepatitis E Virus infection with coincident reactivation of Epstein-Barr virus infection in an immunosuppressed patient with rheumatoid arthritis: a case report.

    Science.gov (United States)

    Schultze, Detlev; Mani, Bernhard; Dollenmaier, Günter; Sahli, Roland; Zbinden, Andrea; Krayenbühl, Pierre Alexandre

    2015-10-29

    Hepatitis E virus (HEV) is the most recently discovered of the hepatotropic viruses, and is considered an emerging pathogen in developed countries with the possibility of fulminant hepatitis in immunocompromised patients. Especially in the latter elevated transaminases should be taken as a clue to consider HEV infection, as it can be treated by discontinuation of immunosuppression and/or ribavirin therapy. To our best knowledge, this is a unique case of autochthonous HEV infection with coincident reactivation of Epstein-Barr virus (EBV) infection in an immunosuppressed patient with rheumatoid arthritis (RA). A 68-year-old Swiss woman with RA developed hepatitis initially diagnosed as methotrexate-induced liver injury, but later diagnosed as autochthonous HEV infection accompanied by reactivation of her latent EBV infection. She showed confounding serological results pointing to three hepatotropic viruses (HEV, Hepatitis B virus (HBV) and EBV) that could be resolved by detection of HEV and EBV viraemia. The patient recovered by temporary discontinuation of immunosuppressive therapy. In immunosuppressed patients with RA and signs of liver injury, HEV infection should be considered, as infection can be treated by discontinuation of immunosuppression. Although anti-HEV-IgM antibody assays can be used as first line virological tools, nucleic acid amplification tests (NAAT) for detection of HEV RNA are recommended--as in our case--if confounding serological results from other hepatotropic viruses are obtained. After discontinuation of immunosuppressive therapy, our patient recovered from both HEV infection and reactivation of latent EBV infection without sequelae.

  16. Interaction of displacement cascade with helium bubbles in α-iron: Computer simulation

    International Nuclear Information System (INIS)

    Pu, J.; Yang, L.; Gao, F.; Heinisch, H.L.; Kurtz, R.J.; Zu, X.T.

    2008-01-01

    Molecular dynamics (MD) method has been performed to study the interaction of displacement cascade with He bubbles with two sets of potentials. The results show that the stability of He bubbles depends much on the initial He-vacancy (He/V) ratio and the recoil energy. For an initial He/V ratio of 3, the cascade leads to the increase in the number of vacancies in the He bubble and the decrease in the He/V ratio. For an initial He/V ratio of 0.5, the interaction of a cascade with the He/V bubble results in the decrease in the number of vacancies and the increase in the He/V ratio. For an initial He/V ratio of 1, the stability of the bubbles slightly depends on the primary knock-on atom (PKA) energy. Furthermore, a large number of self-interstitial atom clusters are formed after cascade collision for the He/V ratio of 3, while large vacancy clusters are observed for the He/V ratio of 0.5. However, some differences of defect production and clustering between the two sets of potentials are observed, which may be associated the formation energies of He-V clusters, the binding energies of vacancies and He atoms to the clusters and the probability of subcascade formation

  17. Identification and characterization of two linear epitope motifs in hepatitis E virus ORF2 protein.

    Directory of Open Access Journals (Sweden)

    Heng Wang

    Full Text Available Hepatitis E virus (HEV is responsible for hepatitis E, which represents a global public health problem. HEV genotypes 3 and 4 are reported to be zoonotic, and animals are monitored for HEV infection in the interests of public hygiene and food safety. The development of novel diagnostic methods and vaccines for HEV in humans is thus important topics of research. Opening reading frame (ORF 2 of HEV includes both linear and conformational epitopes and is regarded as the primary candidate for vaccines and diagnostic tests. We investigated the precise location of the HEV epitopes in the ORF2 protein. We prepared four monoclonal antibodies (mAbs against genotype 4 ORF2 protein and identified two linear epitopes, G438IVIPHD444 and Y457DNQH461, corresponding to two of these mAbs using phage display biopanning technology. Both these epitopes were speculated to be universal to genotypes 1, 2, 3, 4, and avian HEVs. We also used two 12-mer fragments of ORF2 protein including these two epitopes to develop a peptide-based enzyme-linked immunosorbent assay (ELISA to detect HEV in serum. This assay demonstrated good specificity but low sensitivity compared with the commercial method, indicating that these two epitopes could serve as potential candidate targets for diagnosis. Overall, these results further our understanding of the epitope distribution of HEV ORF2, and provide important information for the development of peptide-based immunodiagnostic tests to detect HEV in serum.

  18. Surveillance of Hepatitis E Virus Contamination in Shellfish in China

    Directory of Open Access Journals (Sweden)

    Shenyang Gao

    2015-02-01

    Full Text Available Background: Hepatitis E virus (HEV has been confirmed to be a zoonotic virus of worldwide distribution. HEV contamination in the water environment has not been well examined in China. The objective of this study was to evaluate HEV contamination in shellfish in a coastal area of China. Such contamination would be significant for evaluating public health risks. Methods: samples of three species shellfish were collected from thirteen points of estuarine tidal flats around the Bohai Gulf and screened for HEV RNA using an in-house nested RT-PCR assay. The detected HEV-positive samples were further verified by gene cloning and sequencing analysis. Results: the overall HEV-positive detection rate is approximately 17.5% per kilogram of shellfish.  HEV was more common among S. subcrenata (28.2%, followed by A. granosa (14.3% and R. philippinarum (11.5%. The phylogenetic analysis of the 13 HEV strains detected revealed that gene fragments fell into two known 4 sub-genotypes (4b/4d groups and another unknown group. Conclusions: 13 different sub-genotype 4 HEVs were found in contaminated shellfish in the Bohai Gulf rim. The findings suggest that a health risk may exist for users of waters in the Bonhai area and to consumers of shellfish.  Further research is needed to assess the sources and infectivity of HEV in these settings, and to evaluate additional shellfish harvesting areas.

  19. Analytical framework for analyzing the energy conversion efficiency of different hybrid electric vehicle topologies

    International Nuclear Information System (INIS)

    Katrasnik, Tomaz

    2009-01-01

    Energy consumption and exhaust emissions of hybrid electric vehicles (HEVs) strongly depend on the HEV topology, power ratios of the components and applied control strategy. There are many available patterns of combining the power flows to meet load requirements making it difficult to analyze and evaluate a newly designed HEV. In order to enhance design of HEVs, the paper provides a stand alone analytical framework for evaluating energy conversion phenomena of different HEV topologies. Analytical analysis is based on the energy balance equations and considers the complete energy path in the HEVs from the energy sources to the wheels and to other energy sinks. The analytical framework enables structuring large amount of data in physically meaningful energy flows and associated energy losses, and therefore provides insightful information for HEV optimization. It therefore enables identification of most suitable HEV topology and of most suitable power ratios of the components, since it reveals and quantifies the instruments that could lead to improved energy conversion efficiency of particular HEV. The analytical framework is also applicable for correcting the energy consumption of the HEV to the value corresponding to balanced energy content of the electric storage devices.

  20. [Hepatitis E virus: Blood transfusion implications].

    Science.gov (United States)

    Gallian, P; Piquet, Y; Assal, A; Djoudi, R; Chiaroni, J; Izopet, J; Tiberghien, P

    2014-11-01

    Hepatitis E virus (HEV) is a non-enveloped RNA virus transmitted by the fecal-oral route. Autochthonous hepatitis E occurring in developed countries is caused by genotypes 3 and 4 and is a zoonotic infection. Humans are infected mostly after ingestion of undercooked meat from infected animals. Most HEV 3 and 4 infections are clinically inapparent. However, genotype 3 (HEV 3) can lead to chronic hepatitis in immuno-compromised patients such as organ-transplant recipients and patients with haematological malignancies. In Europe, HEV 3 is implicated in transfusion-transmitted HEV infection. In France, as observed in several European countries, prevalence of HEV RNA and specific IgG antibodies are high indicating that viral circulation is important. The systematic HEV NAT screening of blood donations used for preparation of solvent detergent plasma indicate that 1 to 2218 donation is infected by HEV RNA. The need or implementation's impacts of safety measures to prevent HEV transmission by blood transfusion are under reflexion by French's health authorities. The HEV NAT screening is the only available tool of prevention. Alternative strategies are under investigation including individual or mini pool NAT testing all or part of blood donations. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  1. Hepatitis E Virus Genotype 3 in Sewage and Genotype 1 in Acute Hepatitis Cases, Israel

    Science.gov (United States)

    Ram, Daniela; Manor, Yossi; Gozlan, Yael; Schwartz, Eli; Ben-Ari, Ziv; Mendelson, Ella; Mor, Orna

    2016-01-01

    Hepatitis E virus (HEV) is an emerging infectious agent in developed countries. HEV genotypes 1 (G1) and 3 (G3) have been identified in environmental and clinical samples in Europe. In Israel, the overall prevalence of anti-HEV IgG antibodies was found to be 10.6%; however, reports of HEV infection are scarce. In this study, the presence of HEV in Israel was investigated using 169 sewage samples from 32 treatment facilities and 49 samples from acute hepatitis patients, all collected between 2013 and 2015. Fourteen sewage samples, from Haifa (11/18 samples), Tel Aviv (2/29 samples), and Beer Sheva (1/17 samples), regions with good sanitary conditions and middle-high socioeconomic populations, were HEV positive. Among the patient samples, 6.1% (3/49) were HEV positive, all returning travelers from India. Genotype analysis revealed G1 HEV in patients and G3 HEV sequences in sewage. Evidence that HEV could be establishing itself in our region may justify more active surveillance to monitor its spread. PMID:27246446

  2. Seroprevalence of anti-hepatitis E virus antibodies in domestic pigs in Mexico.

    Science.gov (United States)

    García-Hernández, Montserrat Elemi; Cruz-Rivera, Mayra; Sánchez-Betancourt, José Iván; Rico-Chávez, Oscar; Vergara-Castañeda, Arely; Trujillo, María E; Sarmiento-Silva, Rosa Elena

    2017-09-21

    Hepatitis E virus (HEV) infection is one of the most common causes of acute liver diseases in humans worldwide. In developing countries, HEV is commonly associated with waterborne outbreaks. Conversely, in industrialized countries, HEV infection is often associated with travel to endemic regions or ingestion of contaminated animal products. Limited information on both, human and animal HEV infection in Mexico is available. As a consequence, the distribution of the virus in the country is largely unknown. Here, we assessed the seroprevalence of HEV among swine in different geographical regions in Mexico. Seroprevalence of anti-HEV antibodies in swine herds in Mexico was evaluated in a representative sample including 945 pig serum specimens from different regions of the country using a commercial enzyme-linked immunosorbent assay (ELISA). The overall prevalence of anti-HEV antibodies in swine was 59.4%. The northern region of Mexico exhibited the highest seroprevalence in the country (86.6%), while the central and southern regions in Mexico showed lower seroprevalence, 42.7% and 51.5%, respectively. In Mexico, HEV seroprevalence in swine is high. Importantly, northern Mexico showed the highest seroprevalence in the country. Thus, further studies are required to identify the risk factors contributing to HEV transmission among pigs in the country. Assessment of HEV human infection in the context of viral transmission in swine is required to better understand the epidemiology of hepatitis E in Mexico.

  3. Cellular receptors for human enterovirus species A

    Directory of Open Access Journals (Sweden)

    Yorihiro eNishimura

    2012-03-01

    Full Text Available Human enterovirus species A (HEV-A is one of the four species of HEV in the genus Enterovirus in the family Picornaviridae. Among HEV-A, coxsackievirus A16 (CVA16 and enterovirus 71 (EV71 are the major causative agents of hand, foot, and mouth disease (HFMD. Some other types of HEV-A are commonly associated with herpangina. Although HFMD and herpangina due to HEV-A are common febrile diseases among infants and children, EV71 can cause various neurological diseases, such as aseptic meningitis and fatal encephalitis.Recently, two human transmembrane proteins, P-selectin glycoprotein ligand-1 (PSGL-1 and scavenger receptor class B, member 2 (SCARB2, were identified as functional receptors for EV71 and CVA16. In in vitro infection experiments using the prototype HEV-A strains, PSGL-1 and SCARB2 could be responsible for the specific receptors for EV71 and CVA16. However, the involvement of both receptors in the in vitro and in vivo infections of clinical isolates of HEV-A has not been clarified yet. To elucidate a diverse array of the clinical outcome of HEV-A-associated diseases, the identification and characterization of HEV-A receptors may provide useful information in understanding the HEV-A pathogenesis at a molecular level.

  4. Determination of hemispheric emotional valence in individual subjects: A new approach with research and therapeutic implications

    Directory of Open Access Journals (Sweden)

    Polcari Ann

    2007-03-01

    Full Text Available Abstract Background Much has been theorized about the emotional properties of the hemispheres. Our review of the dominant hypotheses put forth by Schore, Joseph, Davidson, and Harmon-Jones on hemispheric emotional valences (HEV shows that none are supported by robust data. Instead, we propose that individual's hemispheres are organized to have differing HEVs that can be lateralized in either direction. Methods Probe auditory evoked potentials (AEP recorded during a neutral and an upsetting memory were used to assess HEV in 28 (20 F right-handed subjects who were either victims of childhood maltreatment (N = 12 or healthy controls. In a sub-population, we determined HEV by emotional response to lateral visual field stimulation (LVFS, in which vision is limited to one, then the other hemifield. We compare a number of morphometric and functional brain measures between individuals who have right-negative versus left-negative HEV. Results Using AEPs to determine HEV, we found 62% of controls and 67% of maltreated subjects had right negative HEV. There was a strong interaction between HEV-laterality and gender, which together accounted for 60% of individual variability in total grey matter volume (GMV. HEV-laterality was associated with differences in hippocampal volume, amygdala/hippocampal ratios, and measures of verbal, visual and global memory. HEV-laterality was associated also with different constellations of symptoms comparing maltreated subjects to controls. Emotional response to LVFS provided a convenient and complementary measure of HEV-laterality that correlated significantly with the HEVs determined by AEPs. Conclusion Our findings suggest that HEV-laterality, like handedness or gender, is an important individual difference with significant implications for brain and behavioral research, and for guiding lateralized treatments such as rTMS.

  5. Acute hepatitis E in a renal transplantation recipient: a case report.

    Science.gov (United States)

    Shindo, Mitsutoshi; Takemae, Hiroaki; Kubo, Takafumi; Soeno, Masatsugu; Ando, Tetsuo; Morishita, Yoshiyuki

    2018-01-01

    Hepatitis E is caused by infection with the hepatitis E virus (HEV). HEV is transmitted orally via HEV-contaminated food or drink. Hepatitis E usually shows mild symptoms and is self-limiting in the general population; however, it may progress to chronic hepatitis in immunosuppressed patients such as recipients of organ transplantation. However, a few cases of acute hepatitis E have been reported in organ transplantation recipients. We herein report a case of acute hepatitis E in a 31-year-old male renal transplant recipient. The patient underwent renal transplantation 2 years ago, and his postoperative course was uneventful without rejection. After complaining of general fatigue and low-grade fever for 1 week, he was referred to and admitted to our hospital. Careful interview revealed that he ate undercooked pork 10 weeks prior. Blood analysis revealed liver dysfunction but was serologically negative for hepatitis A, B and C virus, cytomegalovirus infection and collagen diseases. Immunoglobulin A antibody against hepatitis E virus (HEV-IgA) was also negative at that point. After 2 weeks of admission, HEV-IgA and HEV-RNA were measured again as hepatitis E could not be ruled out due to history of ingestion of undercooked meat that may have been contaminated with HEV. At that time, HEV-IgA and HEV-RNA (genotype 3) were positive. Thus, an acute hepatitis E was diagnosed. His liver function gradually improved to within the normal range, and HEV-IgA and HEV-RNA were negative at 11 weeks after admission. In conclusion, we describe here a case of acute hepatitis E in a renal transplant recipient. Careful interview regarding the possibility of ingestion of HEV-contaminated food and repeated measurements of HEV-IgA were helpful in finalizing a diagnosis.

  6. Excretion of infectious hepatitis E virus into milk in cows imposes high risks of zoonosis.

    Science.gov (United States)

    Huang, Fen; Li, Yunlong; Yu, Wenhai; Jing, Shenrong; Wang, Jue; Long, Feiyan; He, Zhanlong; Yang, Chenchen; Bi, Yanhong; Cao, Wentao; Liu, Chengbo; Hua, Xiuguo; Pan, Qiuwei

    2016-08-01

    Hepatitis E virus (HEV) represents the main cause of acute hepatitis worldwide. HEV infection in immunocompromised patients involves a high risk for the development of chronic hepatitis. Because HEV is recognized as a zoonotic pathogen, it is currently believed that swine is the primary reservoir. However, this is not sufficient to justify the strikingly high seroprevalence of HEV in both developing and Western countries. Thus, this study aimed to identify new zoonotic sources that bear a high risk of transmission to humans. We collected fecal, blood, and milk samples of cows in a typical rural region of Yunnan Province in southwest China, where mixed farming of domestic animals is a common practice. HEV RNA was quantified by quantitative real-time polymerase chain reaction, and the whole genome was sequenced. HEV infectivity was assessed in rhesus macaques. We found a high prevalence of active HEV infection in cows as determined by viral RNA positivity in fecal samples. Surprisingly, we discovered that HEV is excreted into milk that is produced by infected cows. Phylogenetic analysis revealed that all HEV isolates from cow/milk belong to genotype 4 and subtype 4h. Gavage with HEV-contaminated raw and even pasteurized milk resulted in active infection in rhesus macaques. Importantly, a short period of boiling, but not pasteurization, could completely inactivate HEV. Infectious HEV-contaminated cow milk is recognized as a new zoonotic source that bears a high risk of transmission to humans; these results call attention to understanding and establishing proper measurement and control of HEV zoonotic transmission, particularly in the setting of mixed farming of domestic animals. (Hepatology 2016;64:350-359). © 2016 by the American Association for the Study of Liver Diseases.

  7. Determination of hemispheric emotional valence in individual subjects: a new approach with research and therapeutic implications.

    Science.gov (United States)

    Schiffer, Fredric; Teicher, Martin H; Anderson, Carl; Tomoda, Akemi; Polcari, Ann; Navalta, Carryl P; Andersen, Susan L

    2007-03-06

    Much has been theorized about the emotional properties of the hemispheres. Our review of the dominant hypotheses put forth by Schore, Joseph, Davidson, and Harmon-Jones on hemispheric emotional valences (HEV) shows that none are supported by robust data. Instead, we propose that individual's hemispheres are organized to have differing HEVs that can be lateralized in either direction. Probe auditory evoked potentials (AEP) recorded during a neutral and an upsetting memory were used to assess HEV in 28 (20 F) right-handed subjects who were either victims of childhood maltreatment (N = 12) or healthy controls. In a sub-population, we determined HEV by emotional response to lateral visual field stimulation (LVFS), in which vision is limited to one, then the other hemifield. We compare a number of morphometric and functional brain measures between individuals who have right-negative versus left-negative HEV. Using AEPs to determine HEV, we found 62% of controls and 67% of maltreated subjects had right negative HEV. There was a strong interaction between HEV-laterality and gender, which together accounted for 60% of individual variability in total grey matter volume (GMV). HEV-laterality was associated with differences in hippocampal volume, amygdala/hippocampal ratios, and measures of verbal, visual and global memory. HEV-laterality was associated also with different constellations of symptoms comparing maltreated subjects to controls. Emotional response to LVFS provided a convenient and complementary measure of HEV-laterality that correlated significantly with the HEVs determined by AEPs. Our findings suggest that HEV-laterality, like handedness or gender, is an important individual difference with significant implications for brain and behavioral research, and for guiding lateralized treatments such as rTMS.

  8. Hepatitis E in liver transplant recipients in the Rhône-Alpes region in France.

    Science.gov (United States)

    Buffaz, C; Scholtes, C; Dron, A-G; Chevallier-Queyron, P; Ritter, J; André, P; Ramière, C

    2014-06-01

    In developed countries, hepatitis E virus (HEV) is considered an emerging pathogen, but prevalence seems highly variable according to previous European studies. As HEV can lead to chronic infections in immunosuppressed patients, it is thus essential to evaluate the prevalence and incidence of this infection. We determined retrospectively, in a cohort of 206 pediatric and adult liver transplant recipients from the Rhône-Alpes region in France, pre-transplant anti-HEV-IgG prevalence and incidence of HEV infections during post-transplant follow-up (HEV IgG and IgM ± HEV-RNA). Transplantations were carried out between 2005 and 2012 and mean post-transplant follow-up was 32.8 months. Global pre-transplant prevalence of anti-HEV IgG was 29%, increasing regularly with age from 7% for children under 15 to 49% for patients older than 60. From the 142 seronegative patients before transplant, 11 seroconversions (7.7%) were observed during follow-up (incidence of 2.83 cases per 100 person-years). HEV RNA-tested at transaminases peak or randomly-was detected in only one case of seroconversion. For at least 2 HEV-seropositive patients, who had negative RNAemia before transplantation, viral RNA was detected chronically during follow-up, suggesting reinfection with HEV. Acute infections were largely more frequent than chronic infections and were asymptomatic or misdiagnosed, suggesting that liver transplant patients may not be particularly prone to developing severe HEV hepatitis. In addition, the presence of IgG anti-HEV may not protect against re-infection. Serological testing, therefore, appears to be of limited interest for the diagnosis of HEV infections in liver transplant recipients.

  9. Prevalence, risk factors and molecular evaluation of hepatitis E virus infection among pregnant women resident in the northern shores of Persian Gulf, Iran

    Science.gov (United States)

    Farshadpour, Fatemeh; Ravanbod, Mohamad Reza; Eghbali, Seyed Sajjad; Taherkhani, Sakineh; Mahdavi, Easa

    2018-01-01

    Background Although Iran is reported to be an endemic country for hepatitis E virus (HEV), data on the prevalence of HEV infection among pregnant women are scarce and the epidemiology of HEV is unknown in most parts of the country. Therefore, this study was conducted to elucidate the prevalence, risk factors and genotypic pattern of HEV infection among pregnant women resident in the northern shores of Persian Gulf. This is the first report on the epidemiology of HEV infection among pregnant women in this territory. Methods From October 2016 to May 2017, 1331 pregnant women participated in this study. The mean age ± SD of participants was 27.93±5.7 years with a range of 14–45 years. Serum samples of pregnant women were screened for the presence of anti-HEV total antibodies, anti-HEV IgG and anti-HEV IgM using commercially available ELISA kits (DIA.PRO, Milan, Italy). All anti-HEV IgG and anti-HEV IgM positive samples were tested for HEV RNA using two independent reverse transcriptase polymerase chain reaction (RT-PCR) assays, targeting ORF2 and ORF3 of HEV genome. In addition, 92 anti-HEV seronegative samples as well as 50 pooled seronegative samples were evaluated by two independent RT-PCR assays for validation of results. Results Of the 1331 pregnant women, 84 women (6.3%, 95% CI: 5.1%-7.7%) were positive for anti-HEV antibodies, of which 83 women had anti-HEV IgG, and 11 women (0.83%, 95% CI: 0.47%-1.47%) had anti-HEV IgM. The highest rate of HEV seroprevalence was observed among Afghan immigrants (68.0%), uneducated pregnant women (46.51%) and those residents in Bushehr city (8.75%). All anti-HEV IgG and/or IgM positive samples were found to be negative for HEV RNA. In addition, all of the evaluated anti-HEV seronegative samples were negative for HEV RNA. HEV seropositivity among pregnant women was statistically associated with age, ethnicity, place of residence, number of pregnancies, and level of education. So that, low education levels, Afghan, residence

  10. Hepatitis E virus antibody prevalence in hunters from a district in Central Germany, 2013: a cross-sectional study providing evidence for the benefit of protective gloves during disembowelling of wild boars.

    Science.gov (United States)

    Schielke, A; Ibrahim, V; Czogiel, I; Faber, M; Schrader, C; Dremsek, P; Ulrich, R G; Johne, R

    2015-10-22

    In Germany, 17% of the general human population have antibodies to hepatitis E virus (HEV) (recomLine HEV-IgG/IgM immunoassay [Mikrogen GmbH]). Wild boars represent an animal reservoir for HEV genotype 3, which is the common genotype in Germany. We estimated the seroprevalence among hunters with contact to wild boars to identify factors that may be associated with past or present HEV infection. In 2013, the local veterinarian authority in a district in Central Germany attended meetings of hunters who provided blood specimens and completed a questionnaire collecting information on age, sex, hunting-related activities and consumption of wild boar meat. Specimens of wild boars were taken during drive hunts in this district during the season 2012/2013. All specimens were tested for HEV RNA and anti-HEV IgM and IgG antibodies. Log-binomial regression was used to estimate prevalence ratios (PR) for the hunters. Of 126 hunters (median age 55; 94% male) 21% tested positive for anti-HEV IgG antibodies (95% confidence interval [CI] 13-28%) (recomWell HEV IgG assay [Mikrogen GmbH]). Anti-HEV prevalence was highest in the age group of the 70-79-year-olds (67%; 95% CI 39-95%). Wild boars showed an average anti-HEV prevalence of 41%. HEV RNA was detected in 4/22 (18%) liver specimens and in 1/22 (4.5%) muscle specimens. Most wild boars were tested positive for HEV RNA (3/10; 30%) and HEV-specific antibodies (7/15; 47%) in the southwestern part of the district. Hunters preferring this hunting ground had a lower anti-HEV prevalence when gloves were frequently used during disembowelling of wild boars compared to hunters using gloves never or infrequently (age-adjusted PR 0.12; 95% CI 0.02-0.86). Hunters may benefit from wearing gloves when in contact with blood or body fluids of HEV animal reservoirs. Anti-HEV prevalence among the hunters of this study did not significantly differ from that of the general population suggesting that other factors play a major role in the

  11. Seroprevalence of Hepatitis E Virus in Four Species of Parrots in China

    Directory of Open Access Journals (Sweden)

    Xiao-Xuan Zhang, Nian-Zhang Zhang, Dong-Hui Zhou, Wei-Peng Tian, Ying-Tian Xu and Xing-Quan Zhu

    2014-01-01

    Full Text Available In this study, antibodies against avian Hepatitis E Virus (avian HEV were detected in 6.43% of examined serum samples (n=311 from budgerigars (Melopsittacus undulatus, lovebirds (Agapornis sp., cockatiel (Nymphicus hollandicus and Alexandrine parakeets (Psittacula eupatria by indirect ELISA. Seroprevalence of avian HEV infection in different parrot species varied from 0 to 7.92%. Statistical analysis of the origins of parrots demonstrated that parrots from Weifang city had a higher avian HEV seropositivity (7.84% compared with parrots from Beijing city (5.06%. The seroprevalence in parrots of different age groups varied from 4 to 7.62%. The avian HEV seroprevalence in parrots examined in spring and summer was 7.19 and 5.81%, respectively. This is the first report of avian HEV seroprevalence in four species of parrots in China, which will provide base-line data for the control of HEV infection in parrots in China.

  12. A comprehensive overview of hybrid electric vehicle: Powertrain configurations, powertrain control techniques and electronic control units

    Energy Technology Data Exchange (ETDEWEB)

    Cagatay Bayindir, Kamil; Goezuekuecuek, Mehmet Ali; Teke, Ahmet [Cukurova University, Department of Electrical and Electronics Engineering, Balcali, Saricam, Adana (Turkey)

    2011-02-15

    The studies for hybrid electrical vehicle (HEV) have attracted considerable attention because of the necessity of developing alternative methods to generate energy for vehicles due to limited fuel based energy, global warming and exhaust emission limits in the last century. HEV incorporates internal composition engine, electric machines and power electronic equipments. In this study, overview of HEVs with a focus on hybrid configurations, energy management strategies and electronic control units are presented. Advantages and disadvantages of each configuration are clearly emphasized. The existing powertrain control techniques for HEVs are classified and comprehensively described. Electronic control units used in HEV configuration are also elaborated. The latest trends and technological challenges in the near future for HEVs are discussed. (author)

  13. Structure of Hepatitis E Virion-Sized Particle Reveals an RNA-Dependent Viral Assembly Pathway

    Energy Technology Data Exchange (ETDEWEB)

    Xing, L.; Wall, J.; Li, T.-C.; Mayazaki, N.; Simon, M. N.; Moore, M.; Wang, C.-Y.; Takeda, N.; Wakita, T.; Miyamura, T.; Cheng, R. H.

    2010-10-22

    Hepatitis E virus (HEV) induces acute hepatitis in humans with a high fatality rate in pregnant women. There is a need for anti-HEV research to understand the assembly process of HEV native capsid. Here, we produced a large virion-sized and a small T=1 capsid by expressing the HEV capsid protein in insect cells with and without the N-terminal 111 residues, respectively, for comparative structural analysis. The virion-sized capsid demonstrates a T=3 icosahedral lattice and contains RNA fragment in contrast to the RNA-free T=1 capsid. However, both capsids shared common decameric organization. The in vitro assembly further demonstrated that HEV capsid protein had the intrinsic ability to form decameric intermediate. Our data suggest that RNA binding is the extrinsic factor essential for the assembly of HEV native capsids.

  14. Particle number emissions of gasoline hybrid electric vehicles; Partikelanzahl-Emission bei Hybridfahrzeugen mit Ottomotor

    Energy Technology Data Exchange (ETDEWEB)

    Porter, Scott [Horiba Instruments Inc., Ann Arbor, MI (United States)

    2012-04-15

    Hybrid Electric Vehicles (HEV) are commonly reputed to be environmentally friendly. Different studies show that this assumption raises some questions in terms of particle number emissions. Against the background that upcoming emission standards will not only limit particle matter emissions but also particle number emissions for gasoline engines, the exhaust behaviour of downsized gasoline engines used in HEV should be investigated more extensively. A Horiba study compares the particle number emissions of a gasoline vehicle to those of a gasoline powered HEV. (orig.)

  15. Hepatitis E: an emerging global disease - from discovery towards control and cure.

    Science.gov (United States)

    Khuroo, Mehnaaz S; Khuroo, Mohammad S

    2016-02-01

    Hepatitis E is a systemic disease affecting the liver predominantly and caused by infection with the hepatitis E virus (HEV). HEV has marked genetic heterogeneity and is known to infect several animal species including pigs, boar, deer, mongoose, rabbit, camel, chicken, rats, ferret, bats and cutthroat trout. HEV is the sole member of the family Hepeviridae and has been divided into 2 genera: Orthohepevirus (mammalian and avian HEV) and Piscihepevirus (trout HEV). Human HEVs included within the genus Orthohepevirus are designated Orthohepevirus A (isolates from human, pig, wild boar, deer, mongoose, rabbit and camel). Hepatitis E is an important public health concern, and an estimated one-third of the world population has been infected with HEV. In recent years, autochthonous hepatitis E is recognized as a clinical problem in industrialized countries. Several animal species especially domestic swine, wild boar and wild deer are reservoirs of genotype HEV-3 and HEV-4 in these countries. Human infections occur through intake of uncooked or undercooked meat of the infected animals and pig livers or sausages made from these livers and sold in supermarkets. HEV can be transmitted through blood and blood component transfusions, and donor screening for HEV is under serious consideration. Chronic hepatitis E resulting in rapidly progressive liver cirrhosis and end-stage liver disease has been described in organ transplant patients. Ribavirin monotherapy attains sustained virological response in most patients. HEV 239 vaccine has been marketed in China and its long-term efficacy over four and a half years reported. © 2015 John Wiley & Sons Ltd.

  16. Increased Hepatitis E Virus Seroprevalence Correlates with Lower CD4+ Cell Counts in HIV-Infected Persons in Argentina.

    Directory of Open Access Journals (Sweden)

    José D Debes

    Full Text Available Hepatitis E virus (HEV is a single-stranded RNA virus that can cause hepatitis in an epidemic fashion. HEV usually causes asymptomatic or limited acute infections in immunocompetent individuals, whereas in immunosuppressed individuals such as transplant recipients, HEV can cause chronic infections. The risks and outcomes of HEV co-infection in patients infected with human immunodeficiency virus (HIV are poorly characterized. We used a third generation immunoassay to measure serum IgG antibodies specific for HEV in 204 HIV-infected individuals from Argentina and a control group of 433 HIV-negative individuals. We found 15 of 204 (7.3%, 95%CI 3.74-10.96% individuals in the HIV-positive group to have positive HEV IgG levels suggestive of previous infection, compared to 19 of 433 (4.4%, 95% CI 2.5-6.3% individuals in the HIV-negative control group (p = 0.12. Among HIV-positive individuals, those with HEV seropositivity had lower CD4 counts compared to those that were HEV seronegative (average CD4 count of 234 vs 422 mm3, p = 0.01, indicating that patients with lower CD4 counts were more likely to be HEV IgG positive. Moreover, HEV seropositivity in patients with CD4 counts 200 mm3 (p = 0.012. We found a positive PCR result for HEV in one individual. Our study found that increased seroprevalence of HEV IgG correlated with lower CD4 counts in HIV-infected patients in Argentina.

  17. Hepatitis E virus RNA in Australian blood donations.

    Science.gov (United States)

    Shrestha, Ashish C; Flower, Robert L P; Seed, Clive R; Keller, Anthony J; Harley, Robert; Chan, Hiu-Tat; Hoad, Veronica; Warrilow, David; Northill, Judith; Holmberg, Jerry A; Faddy, Helen M

    2016-12-01

    Hepatitis E virus (HEV) poses a risk to transfusion safety. In Australia, locally acquired HEV is rare and cases are mainly reported in travelers returning from countries endemic for HEV. The risk posed by HEV to transfusion safety in Australia is unknown; therefore, we aimed to measure the rate of current HEV infection in Australian blood donations. A total of 14,799 blood donations were tested for HEV RNA by transcription-mediated amplification, with confirmatory testing by reverse transcription-polymerase chain reaction. Viral load quantification and phylogenetic analysis was performed on HEV RNA-positive samples. One (0.0068%; 95% confidence interval [CI], 0.0002%-0.0376%) sample was confirmed positive for HEV RNA, resulting in a risk of collecting a HEV-viremic donation of 1 in 14,799 (95% CI, 1 in 584,530 to 1 in 2,657). The viral load in this sample was approximately 15,000 IU/mL, and it was determined to be Genotype 3. Our finding of 1 in 14,799 Australian donations positive for HEV RNA is lower than that from many other developed countries; this is consistent with the relatively low seroprevalence in Australia. As this HEV RNA-positive sample was Genotype 3, it seems likely that this infection was acquired through zoonotic transmission, either within Australia or overseas in a developed nation. HEV has the potential to pose a risk to transfusion safety in Australia; however, additional, larger studies are required to quantify the magnitude of this risk. © 2016 AABB.

  18. Coexistence of IgM antihepatitis A virus and IgM antihepatitis E virus in acute viral hepatitis: a prospective, multicentre study in Korea.

    Science.gov (United States)

    Jang, J-H; Jung, Y M; Kim, J S; Lee, S H; Kim, J-W; Hwang, S G; Rim, K S; Park, S J; Park, Y M; Kang, S-K; Lee, H S; Yun, H; Kim, J-H; Jeong, S-H

    2011-10-01

    This study investigated the clinical, serological and molecular characteristics of coexistence of both immunoglobulin M (IgM) antihepatitis A virus (HAV) and IgM antihepatitis E virus (HEV) in acute viral hepatitis using a prospective, multicentre design. Among a total of 771 symptomatic cases with acute viral hepatitis enrolled in a Korean city from September 2006 to August 2008, coexistence of IgM anti-HAV and IgM anti-HEV was found in 43 patients (A+E group; 6%), while the existence of IgM anti-HAV alone was found in 595 patients (A group; 77%) and that of IgM anti-HEV alone in 14 patients (E group; 2%). Clinical data analysis and measurement of IgM and IgG anti-HEV were performed using two different commercial kits, and HAV RNA and HEV RNA were detected in available serum or stool samples. The clinical features of the A+E group were similar to those of the A group. HAV RNA detection rates in the A+E and A group were similar, while HEV RNA was detected only in the stool samples of the E group, not in the A+E group. Comparative testing of anti-HEV using two different ELISA kits showed markedly discordant results for IgM anti-HEV positivity and consistently low positivity for IgG anti-HEV in the A+E group. Coexistence of IgM anti-HEV measured by the Genelabs ELISA kit in the setting of hepatitis A appears to yield false-positive results in nonendemic areas of HEV infection. Diagnosis of hepatitis E using IgM anti-HEV should be made with caution. © 2011 Blackwell Publishing Ltd.

  19. Hepatitis E Virus and Related Viruses in Animals.

    Science.gov (United States)

    Thiry, D; Mauroy, A; Pavio, N; Purdy, M A; Rose, N; Thiry, E; de Oliveira-Filho, E F

    2017-02-01

    Hepatitis E is an acute human liver disease in healthy individuals which may eventually become chronic. It is caused by the hepatitis E virus (HEV) and can have a zoonotic origin. Nearly 57,000 people die yearly from hepatitis E-related conditions. The disease is endemic in both developing and developed countries with distinct epidemiologic profiles. In developing countries, the disease is associated with inadequate water treatment, while in developed countries, transmission is associated with animal contact and the ingestion of raw or uncooked meat, especially liver. All human HEV are grouped into at least four genotypes, while HEV or HEV-related viruses have been identified in an increasing number of domestic and wild animal species. Despite a high genetic diversity, only one single HEV serotype has been described to date for HEV genotypes 1-4. The discovery of new HEV or HEV-related viruses leads to a continuing increase in the number of genotypes. In addition, the genome organization of all these viruses is variable with overlapping open reading frames (ORF) and differences in the location of ORF3. In spite of the role of some domestic and wild animals as reservoir, the origin of HEV and HEV-related viruses in humans and animals is still unclear. This review discusses aspects of the detection, molecular virology, zoonotic transmission and origin of HEV and HEV-related viruses in the context of 'One Health' and establishes a link between the previous and the new taxonomy of this growing virus family. © 2015 Blackwell Verlag GmbH.

  20. First Report of Hepatitis E Virus Infection in Sika Deer in China

    OpenAIRE

    Zhang, Xiao-Xuan; Qin, Si-Yuan; Zhang, Yuan; Meng, Qing-Feng; Jiang, Jing; Yang, Gui-Lian; Zhao, Quan; Zhu, Xing-Quan

    2015-01-01

    Hepatitis E virus (HEV), a single stranded RNA, nonenveloped virus, belongs to the genus Hepevirus, in the family of Hepeviridae. In this study, 46 (5.43%) out of the 847 serum samples from sika deer (Cervus nippon) were detected as seropositive with hepatitis E virus (HEV) by enzyme linked immunosorbent assay (ELISA). These samples were collected from Inner Mongolia and Jilin and Heilongjiang provinces in China, between October 2012 and October 2013. Seroprevalence of HEV infection in male a...

  1. High occurrence of hepatitis E virus in samples from wastewater treatment plants in Switzerland and comparison with other enteric viruses.

    OpenAIRE

    Masclaux, Frédéric G.; Hotz, Philipp; Friedli, Drita; Savova-Bianchi, Dessislava; Oppliger, Anne

    2013-01-01

    Hepatitis E virus (HEV) is responsible for many enterically transmitted viral hepatitides around the world. It is currently one of the waterborne diseases of global concern. In industrialized countries, HEV appears to be more common than previously thought, even if it is rarely virulent. In Switzerland, seroprevalence studies revealed that HEV is endemic, but no information was available on its environmental spread. The aim of this study was to investigate -using qPCR- the occurrence and conc...

  2. Serological Evidence of Hepatitis E Virus Infection in an Indigenous North American Population

    Directory of Open Access Journals (Sweden)

    GY Minuk

    2007-01-01

    Full Text Available BACKGROUND: Hepatitis E virus (HEV infections are thought to be uncommon in North America. Recently, HEV transmission has been reported following the consumption of deer meat. Because deer are closely related to caribou and caribou meat is a staple of the Canadian Inuit and the American Eskimo diet, the present study explored the seroprevalence of HEV infection in an isolated Canadian Inuit community.

  3. Construction of an infectious cDNA clone of genotype 1 avian hepatitis E virus: characterization of its pathogenicity in broiler breeders and demonstration of its utility in studying the role of the hypervariable region in virus replication.

    Science.gov (United States)

    Park, Soo-Jeong; Lee, Byung-Woo; Moon, Hyun-Woo; Sung, Haan Woo; Yoon, Byung-Il; Meng, Xiang-Jin; Kwon, Hyuk Moo

    2015-05-01

    A full-length infectious cDNA clone of the genotype 1 Korean avian hepatitis E virus (avian HEV) (pT11-aHEV-K) was constructed and its infectivity and pathogenicity were investigated in leghorn male hepatoma (LMH) chicken cells and broiler breeders. We demonstrated that capped RNA transcripts from the pT11-aHEV-K clone were translation competent when transfected into LMH cells and infectious when injected intrahepatically into the livers of chickens. Gross and microscopic pathological lesions underpinned the avian HEV infection and helped characterize its pathogenicity in broiler breeder chickens. The avian HEV genome contains a hypervariable region (HVR) in ORF1. To demonstrate the utility of the avian HEV infectious clone, several mutants with various deletions in and beyond the known HVR were derived from the pT11-aHEV-K clone. The HVR-deletion mutants were replication competent in LMH cells, although the deletion mutants extending beyond the known HVR were non-viable. By using the pT11-aHEV-K infectious clone as the backbone, an avian HEV luciferase reporter replicon and HVR-deletion mutant replicons were also generated. The luciferase assay results of the reporter replicon and its mutants support the data obtained from the infectious clone and its derived mutants. To further determine the effect of HVR deletion on virus replication, the capped RNA transcripts from the wild-type pT11-aHEV-K clone and its mutants were injected intrahepatically into chickens. The HVR-deletion mutants that were translation competent in LMH cells displayed in chickens an attenuation phenotype of avian HEV infectivity, suggesting that the avian HEV HVR is important in modulating the virus infectivity and pathogenicity. © 2015 The Authors.

  4. Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark

    DEFF Research Database (Denmark)

    Christensen, Peer B; Engle, Ronald E; Hjort, Charlotte

    2008-01-01

    BACKGROUND: Antibody to hepatitis E virus (anti-HEV) is prevalent in Western countries, where clinical hepatitis E is rarely reported. The aim of this study was to determine the prevalence of anti-HEV among Danish blood donors and Danish farmers. In addition, we compared the prevalence among 2 sets...... groups (P hepatitis A virus were associated with the presence of anti-HEV in multivariate analysis. Among farmers, only age was independently associated with the presence of anti...

  5. Development and evaluation of a real-time method for testing human enteroviruses and coxsackievirus A16.

    Science.gov (United States)

    Chen, Qian; Hu, Zheng; Zhang, Qihua; Yu, Minghui

    2016-05-01

    Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by a group of the human enteroviruses (HEV), including coxsackievirus A16 (CA16) and enterovirus 71 (EV71). In recent years, another HEV-A serotype, CA6 or CA10, has emerged to be one of the major etiologic agents that can induce HFMD worldwide. The objective of this study is to develop specific, sensitive, and rapid methods to help diagnose HEV and CA16 specifically by using simultaneous amplification testing (SAT) based on isothermal amplification of RNA and real-time detection of fluorescence technique, which were named as SAT-HEV and SAT-CA16, respectively (SAT-HEV/SAT-CA16). The specificity and sensitivity of SAT were tested here. SAT-HEV/SAT-CA16 could measure viral titers that were at least 10-fold lower than those measured by real-time PCR. Non-false cross-reactive amplification indicated that SAT-HEV/SAT-CA16 were highly specific with the addition of internal control (IC) RNA (5000 copies/reaction). A total of 198 clinical specimens were assayed by SAT comparing with real-time PCR. The statistically robust assessment of SAT-HEV and HEV-specific real-time PCR plus sequencing reached 99.0% (196/198), with a kappa value of 0.97, and 99.5% (197/198) and a kappa value of 0.99 for CA16, respectively. Additionally, IC prevented false-negative readings and assured the SAT-HEV/SAT-CA16 method's accuracy. Overall, SAT-HEV/SAT-CA16 method may serve as a platform for the simple and rapid detection of HEV/CA16 in time of HFMD outbreak. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Implementation of lean leadership

    Directory of Open Access Journals (Sweden)

    Trenkner Małgorzata

    2016-12-01

    Full Text Available The Toyota case proves that lean leadership is of critical importance for the successful implementation and permanent functioning of Lean Production System. There is no ready formula for developing Toyota style lean leadership. However, one may gain inspiration from its experience.

  7. 75 FR 49945 - In the Matter of Certain Hybrid Electric Vehicles and Components Thereof; Notice of Commission...

    Science.gov (United States)

    2010-08-16

    ... Toyota hybrid vehicles of claims of U.S. Patent No. 5,343,970. On July 19, 2010, Paice and Toyota moved... INTERNATIONAL TRADE COMMISSION [ Inv. No. 337-TA-688] In the Matter of Certain Hybrid Electric Vehicles and Components Thereof; Notice of Commission Determination Not To Review an Initial Determination...

  8. 78 FR 9699 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-11

    .... However, high quality evidence demonstrating their effectiveness, by way of controlled trials, is lacking. This project will be conducted as a partnership between NIOSH and Toyota Motors Engineering & Manufacturing North America, Inc. (TEMA), with the intervention evaluation study taking place at the Toyota...

  9. More Than Just Selling Vehicles

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    FAW Toyota Motor Sales Co. Ltd. (FTMS), a joint vehicle sales venture owned by auto giants China FAW Group Corp. and Toyota Motor Corp., was inaugurated in 2003 in an effort to strengthen the two firms’ operations in the world’s fastest-growing auto mark

  10. Restricting rotation of triple bond through π-stacking interactions in ...

    Indian Academy of Sciences (India)

    SANKARARAMAN

    For various X and Y activation barrier range from 42-79 kJ/mole. Vögtle, F., et.al., Angew. Chem. Int. Ed., 1979, 18, 159. Toyota, S., et.al., Bull. Chem. Soc. Jpn, 2000, 73, 205 and 2591. Toyota, S., et.al., Tetrahedron Lett., 2001, 57, 3521.

  11. Ensuring continuous improvement processes through standardization in the automotive company

    Directory of Open Access Journals (Sweden)

    Marta Jagusiak-Kocik

    2014-06-01

    Full Text Available This chapter presents the concept of standardization. Presented research subject-central lamp, which is part of the car's external illumination. With BOST questionnaire - management principles Toyota's questions were analyzed E6 area associated with the six Toyota management principle

  12. Charge your electric vehicle when driving?; Rijdend je EV opladen?

    Energy Technology Data Exchange (ETDEWEB)

    Ishii, M.

    2012-07-05

    In late June 2012 a team of Japanese Toyota and ToyohashiUniversity of Technology (TUT) successfully developed and demonstrated a new induction charging method for electric vehicles (EV) [Dutch] Eind junidemonstreerde een Japans team van Toyota en ToyohashiUniversity of Technology (TUT) met succes een nieuwe inductie oplaadmethode voor elektrisch vervoer (EV)

  13. 77 FR 25055 - Addition of Certain Persons to the Entity List

    Science.gov (United States)

    2012-04-27

    ..., Dubai, U.A.E.; and 1st Street, Industrial Area 4th, Sharajah, U.A.E. (Behind the Toyota Showroom); and P..., Dubai, U.A.E.; and 1st Street, Industrial Area 4th, Sharajah, U.A.E. (Behind the Toyota Showroom), and P...

  14. KEPERCAYAAN SEBAGAI MEDIASI HUBUNGAN CORPORATE IMAGE TERHADAP LOYALITAS PELANGGAN MOBIL LOW MPV

    Directory of Open Access Journals (Sweden)

    Iva Nurdiana Nurfarida

    2017-01-01

    Full Text Available The program's cost environmentally friendly cars or Low MPV (LCGC issued by the Indonesian government to bring the impact of the availability of consumer choices Indonesia to buy a car at a bargain price. The challenge is whether consumers have confidence that the car MPV although low cost but still quality. Nearly all car manufacturers to get the car with this type so that competition in the automotive business has become very competitive. This study aims to determine causality corporate image to build customer trust and customer loyalty Low MPV car. The study was conducted on customers of Toyota cars, with the number of respondents 150, using accidental sampling and technique using path analysis. The results that the corporate image has a direct influence on the increase in customer loyalty, as well as striving indirectly through increased customer confidence LCGC Toyota. Manufacturer Toyota has the advantage of the corporate image of the customer against Toyota is high, so the products LCGC Toyota produced can be accepted by consumers for consumers / customers have a loyalty to Toyota, meaning that the high corporate image car customers LCGC Toyota lead to customer loyalty. Another result of this study that the corporate image is also able to increase customer confidence LCGC Toyota subsequent impact on improving customer loyalty, meaning that belief becomes a mediation of the causal relationship of corporate image on customer loyalty.

  15. Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase.

    Science.gov (United States)

    Kaushik, Nidhi; Subramani, Chandru; Anang, Saumya; Muthumohan, Rajagopalan; Shalimar; Nayak, Baibaswata; Ranjith-Kumar, C T; Surjit, Milan

    2017-11-01

    Hepatitis E virus (HEV) causes an acute, self-limiting hepatitis in healthy individuals and leads to chronic disease in immunocompromised individuals. HEV infection in pregnant women results in a more severe outcome, with the mortality rate going up to 30%. Though the virus usually causes sporadic infection, epidemics have been reported in developing and resource-starved countries. No specific antiviral exists against HEV. A combination of interferon and ribavirin therapy has been used to control the disease with some success. Zinc is an essential micronutrient that plays crucial roles in multiple cellular processes. Zinc salts are known to be effective in reducing infections caused by few viruses. Here, we investigated the effect of zinc salts on HEV replication. In a human hepatoma cell (Huh7) culture model, zinc salts inhibited the replication of genotype 1 (g-1) and g-3 HEV replicons and g-1 HEV infectious genomic RNA in a dose-dependent manner. Analysis of a replication-defective mutant of g-1 HEV genomic RNA under similar conditions ruled out the possibility of zinc salts acting on replication-independent processes. An ORF4-Huh7 cell line-based infection model of g-1 HEV further confirmed the above observations. Zinc salts did not show any effect on the entry of g-1 HEV into the host cell. Furthermore, our data reveal that zinc salts directly inhibit the activity of viral RNA-dependent RNA polymerase (RdRp), leading to inhibition of viral replication. Taken together, these studies unravel the ability of zinc salts in inhibiting HEV replication, suggesting their possible therapeutic value in controlling HEV infection. IMPORTANCE Hepatitis E virus (HEV) is a public health concern in resource-starved countries due to frequent outbreaks. It is also emerging as a health concern in developed countries owing to its ability to cause acute and chronic infection in organ transplant and immunocompromised individuals. Although antivirals such as ribavirin have been used

  16. High prevalence of hepatitis E virus antibodies in Sao Paulo, Southeastern Brazil: analysis of a group of blood donors representative of the general population.

    Science.gov (United States)

    Passos-Castilho, Ana Maria; Reinaldo, Mônica Renata; Sena, Anne de; Granato, Celso F H

    Brazil is a non-endemic country for hepatitis E virus (HEV) infection with seroprevalence from 1% to 4% in blood donors and the general population. However, data on seroprevalence of HEV in the country are still limited. This study evaluated the prevalence of past or present HEV infection in a group of blood donors representative of the general population of the city of Sao Paulo, Southeastern Brazil. Serum samples from 500 blood donors were tested from July to September 2014 by serological and molecular methods. Anti-HEV IgG antibodies were detected in 49 (9.8%) subjects and categorized age groups revealed an age-dependent increase of HEV seroprevalence. Among the anti-HEV IgG positive subjects, only 1 had anti-HEV IgM while none tested positive for HEV-RNA. The present data demonstrate a higher seroprevalence of anti-HEV IgG than previously reported in the region. Copyright © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

  17. [Molecular detection of hepatitis E virus in pig livers destined for human consumption in the state of Nuevo Leon, Mexico].

    Science.gov (United States)

    Cantú-Martínez, Marco Antonio; Roig-Sagués, Artur Xavier; Cedillo-Rosales, Sibilina; Zamora-Ávila, Diana Elisa; Avalos-Ramírez, Ramiro

    2013-04-01

    Molecular detection of HEV in pig livers destined for human consumption in Nuevo Leon, Mexico. 87 livers were collected from pigs slaughtered in TIF and 40 livers from butchers. A 212 pb fragment of HEV ORF2 gene was amplified by semi-nested RT-PCR. 19.54% (17) of tif's and 22.5% (9) of butcher's livers were positive for HEV. Sequencing of the amplified products showed a 94%-95% homology with the sequences reported for genotype 3. Our results indicate that HEV is circulating in swine herds in the state, constituting a probable source of contamination of pig meat products.

  18. Adherence of murine lymphocytes to high endothelial venules in vitro and its radiation effect

    Energy Technology Data Exchange (ETDEWEB)

    Lixin, Liu; Zijun, Mao; Zhiwei, Yin [Suzhou Medical Coll., JS (China). Dept. of Pathophysiology

    1991-02-01

    Using the assay of specific adhesion of lymphocytes to high endothelial venules (HEV) on cryostat sections of mesenteric lymph nodes (MLN), the effects of different doses (0, 1, 2, 4, 8 Gy) of {sup 60}Co {gamma}-ray irradiation of murine MLN lymphocytes in vitro on adhesion to normal HEV was observed. The results showed that in the irradiated murine MLN lymphocytes the ability to adhere to HEV of normal MLN was reduced. Statistical significance was revealed at 2, 4, 8 Gy irradiations. This results suggests that irradiation can inhibit the specific recognition and adhesion of lymphocytes to HEV to a certain extent.

  19. Clean Cities Annual Metrics Report 2006

    Energy Technology Data Exchange (ETDEWEB)

    Bergeron, P.; Putsche, V.

    2007-07-01

    Report summarizes Clean Cities coalition accomplishments, including membership, funding, sales of alternative fuel blends, deployment of AFVs and HEVs, idle reduction initiatives, and fuel economy activities.

  20. How hybrid-electric vehicles are different from conventional vehicles: the effect of weight and power on fuel consumption

    International Nuclear Information System (INIS)

    Reynolds, C; Kandlikar, M

    2007-01-01

    An increasingly diverse set of hybrid-electric vehicles (HEVs) is now available in North America. The recent generation of HEVs have higher fuel consumption, are heavier, and are significantly more powerful than the first generation of HEVs. We compare HEVs for sale in the United States in 2007 to equivalent conventional vehicles and determine how vehicle weight and system power affects fuel consumption within each vehicle set. We find that heavier and more powerful hybrid-electric vehicles are eroding the fuel consumption benefit of this technology. Nonetheless, the weight penalty for fuel consumption in HEVs is significantly lower than in equivalent conventional internal combustion engine vehicles (ICEVs). A 100 kg change in vehicle weight increases fuel consumption by 0.7 l/100 km in ICEVs compared with 0.4 l/100 km in HEVs. When the HEVs are compared with their ICEV counterparts in an equivalence model that differentiates between cars and sports-utility vehicles, the average fuel consumption benefit was 2.7 l/100 km. This analysis further reveals that a HEV which is 100 kg heavier than an identical ICEV would have a fuel consumption penalty of 0.15 l/100 km. Likewise, an increase in the HEV's power by 10 kW results in a fuel consumption penalty of 0.27 l/100 km

  1. Seroprevalence of hepatitis E virus among blood donors in Qatar (2013-2016).

    Science.gov (United States)

    Nasrallah, Gheyath K; Al Absi, Enas S; Ghandour, Rula; Ali, Nadima H; Taleb, Sara; Hedaya, Laila; Ali, Fatima; Huwaidy, Mariam; Husseini, Abdullatif

    2017-07-01

    Hepatitis E virus (HEV) is an RNA virus transmitted mainly through zoonotic transmission or fecal-oral route. More than 80% of Qatar's population are expatriates, including many coming from hyperendemic countries; thus, it is important to estimate the seroprevalence and to compare between different nationalities. The results can be useful in alerting blood banks to the importance of HEV screening. Samples from 5854 blood donations provided by Hamad Medical Corporation were tested in the period between June 2013 to June 2016. Samples were tested for the presence of anti-HEV immunoglobulin (Ig)G and IgM antibodies and viral RNA using real-time polymerase chain reaction (PCR). Descriptive statistics, bivariate analysis, and multivariate logistic regression were used. Anti-HEV seroprevalence was 20.7%. A total of 1198 and 38 donations tested positive for IgG and IgM antibodies, respectively. Of the IgM-positive donations four tested positive by PCR. A significant association was detected between HEV seroprevalence with age and nationality. The seroprevalence of anti-HEV was high in Qatar. Since HEV IgM and RNA were detected, this suggests the possibility of HEV transmission by transfusion. Blood banks in Qatar and the region should consider screening for HEV, especially when transfusion is intended to pregnant women or immunocompromised patients. © 2017 AABB.

  2. Testing Low-Energy, High-Power Energy Storage Alternatives in a Full-Hybrid Vehicle (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Cosgrove, J.; Gonger, J.

    2014-01-01

    Automakers have been mass producing hybrid electric vehicles (HEVs) for well over a decade, and the technology has proven to be very effective at reducing per-vehicle gasoline use. However, the battery cost in HEVs contribute to higher incremental cost of HEVs (a few thousand dollars) than the cost of comparable conventional vehicles, which has limited HEV market penetration. Significant cost reductions/performance improvements to the energy storage system (ESS) can improve the vehicle-level cost vs. benefit relationship for HEVs. Such an improvement could lead to larger HEV market penetration and greater aggregate gasoline savings. After significant analysis by the National Renewable Energy Laboratory (NREL), the United States Advanced Battery Consortium (USABC) and Department of Energy (DOE) Energy Storage program suggested a new set of requirements for ESS for power-assist HEVs for cost reduction without impacting performance and fuel economy significantly. With support from DOE, NREL has developed an HEV test platform for in-vehicle performance and fuel economy validation testing of the hybrid system using such LEESS devices. This poster will describe development of the LEESS HEV test platform, and LEESS laboratory as well as in-vehicle evaluation results. The first LEESS technology tested was lithium-ion capacitors (LICs) - i.e., asymmetric electrochemical energy storage devices possessing one electrode with battery-type characteristics (lithiated graphite) and one with ultracapacitor-type characteristics (carbon). We will discuss the performance and fuel saving results with LIC with comparison with original NiMH battery.

  3. Prevalence of Antibodies Against Hepatitis e Virus in Veterinarians in Estonia

    DEFF Research Database (Denmark)

    Lassen, Brian; Janson, Marilin; Neare, Kädi

    2017-01-01

    positive with both tests. Antibody-positive samples were further examined for the presence of HEV RNA. Three (2.6%) of the 115 veterinarians tested positive for immunoglobulin G antibodies against HEV, whereas no immunoglobulin M antibodies against the virus were detected. The antibody......-positive veterinarians were small animal practitioners. Pigs comprised no or small part of their working time or patients. No HEV RNA was detected in the antibody-positive samples. The prevalence of antibodies against HEV in veterinarians in Estonia was lower than what has been observed in veterinarians in other...

  4. Hepatitis E virus is the leading cause of acute viral hepatitis in Lothian, Scotland

    Directory of Open Access Journals (Sweden)

    I. Kokki

    2016-03-01

    Full Text Available Acute viral hepatitis affects all ages worldwide. Hepatitis E virus (HEV is increasingly recognized as a major cause of acute hepatitis in Europe. Because knowledge of its characteristics is limited, we conducted a retrospective study to outline demographic and clinical features of acute HEV in comparison to hepatitis A, B and C in Lothian over 28 months (January 2012 to April 2014. A total of 3204 blood samples from patients with suspected acute hepatitis were screened for hepatitis A, B and C virus; 913 of these samples were also screened for HEV. Demographic and clinical information on patients with positive samples was gathered from electronic patient records. Confirmed HEV samples were genotyped. Of 82 patients with confirmed viral hepatitis, 48 (59% had acute HEV. These patients were older than those infected by hepatitis A, B or C viruses, were more often male and typically presented with jaundice, nausea, vomiting and/or malaise. Most HEV cases (70% had eaten pork or game meat in the few months before infection, and 14 HEV patients (29% had a recent history of foreign travel. The majority of samples were HEV genotype 3 (27/30, 90%; three were genotype 1. Acute HEV infection is currently the predominant cause of acute viral hepatitis in Lothian and presents clinically in older men. Most of these infections are autochthonous, and further studies confirming the sources of infection (i.e. food or blood transfusion are required.

  5. Hepatitis E virus infection as a promoting factor for hepatocellular carcinoma in Cameroon: Preliminary Observations

    Directory of Open Access Journals (Sweden)

    Marie Amougou Atsama

    2017-11-01

    Full Text Available Objectives: To determine the seroprevalence of hepatitis E virus (HEV infection in patients with chronic hepatitis and/or hepatocellular carcinoma (HCC and to assess its potential consequences for disease progression. Methods: We conducted a prospective case-control study on patients with HCC hepatitis B or C related and non-HCC patients including patients with CLD and patients without clinical evidence of liver disease. Anti-HEV IgG and IgM were tested by ELISA using commercially available kits. Liver damage was assessed by alanine aminotransferase, aspartate aminotransferase, platelets and prothrombin measurements. Results: We observed a significant anti-HEV IgG carriage in HCC patients compared to non-HCC subjects with CLD (41.8% vs 12.6%; P = 9.1 E-6; OR = 4.8, 95%CI: 2.3-10.6. HCC patients with HEV infection display more profound alterations of circulating liver enzymes, platelets count and prothrombin time than HCC patients without sero-reactivity to HEV. Conclusion: Overall, this study indicates a high prevalence of HEV infection in Cameroonian patients with CLD and HCC. These data suggest either that patients with liver tumors are more susceptible to hepeviral infection or that, in a tropical context, HEV might promote the progression of liver diseases towards tumor. Keywords: Hepatocellular carcinoma, Hepatitis E, Seroprevalence, Anti-HEV IgG, Anti-HEV IgM

  6. Frequent hepatitis E in the Netherlands without traveling or immunosuppression.

    Science.gov (United States)

    Koot, H; Hogema, B M; Koot, M; Molier, M; Zaaijer, H L

    2015-01-01

    In several Western countries, silent endemic hepatitis E virus (HEV) infection is common among blood donors. Immunocompromised persons may develop chronic hepatitis E, but the relevance of endemic HEV for immunocompetent persons remains largely unknown. We investigated the immune status and travel history in cases of hepatitis E in the Netherlands. Between January 2009 and May 2014, physicians throughout the Netherlands submitted samples from 4067 hepatitis patients to Sanquin Diagnostic Services for HEV antibody testing. For the 144 patients testing positive for HEV IgM and HEV RNA, travel behavior and immune status were assessed. Complete information was obtained for 81 patients. Surprisingly, the majority of patients (52/81, 64%) were immunocompetent and did not travel outside Europe. HEV genotyping was obtained for 47 non-traveling patients, all concerned HEV genotype 3. Our findings suggest that currently in Western countries the impact of hepatitis E for non-traveling, immunocompetent persons is underestimated. Historically cases of hepatitis A, B and C, but not cases of hepatitis E, are notifiable and warrant preventive measures. However, in parts of Western Europe HEV may have become the most important source of viral hepatitis, in immunocompetent and in immunosuppressed persons. Pending measures against the ongoing transmission of HEV genotype 3 in parts of Europe, physicians should consider hepatitis E in dealing with new hepatitis patients. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Establishing operational stability--developing human infrastructure.

    Science.gov (United States)

    Gomez, Max A; Byers, Ernest J; Stingley, Preston; Sheridan, Robert M; Hirsch, Joshua A

    2010-12-01

    Over the past year, Toyota has come under harsh scrutiny as a result of several recalls. These well publicized mishaps have not only done damage to Toyota's otherwise sterling reputation for quality but have also called into question the assertions from a phalanx of followers that Toyota's production system (generically referred to as TPS or Lean) is the best method by which to structure one's systems of operation. In this article, we discuss how Toyota, faced with the pressure to grow its business, did not appropriately cadence this growth with the continued development and maintenance of the process capabilities (vis a vis the development of human infrastructure) needed to adequately support that growth. We draw parallels between the pressure Toyota faced to grow its business and the pressure neurointerventional practices face to grow theirs, and offer a methodology to support that growth without sacrificing quality.

  8. Characterization of self-assembled virus-like particles of dromedary camel hepatitis e virus generated by recombinant baculoviruses.

    Science.gov (United States)

    Zhou, Xianfeng; Kataoka, Michiyo; Liu, Zheng; Takeda, Naokazu; Wakita, Takaji; Li, Tian-Cheng

    2015-12-02

    Dromedary camel hepatitis E virus (DcHEV), a novel hepatitis E virus, has been identified in dromedary camels in Dubai, United Arab Emirates. The antigenicity, pathogenicity and epidemiology of this virus have been unclear. Here we first used a recombinant baculovirus expression system to express the 13 and 111 N-terminus amino-acid-truncated DcHEV ORF2 protein in insect Tn5 cells, and we obtained two types of virus-like particles (VLPs) with densities of 1.300 g/cm(3) and 1.285 g/cm(3), respectively. The small VLPs (Dc4sVLPs) were estimated to be 24 nm in diameter, and were assembled by a protein with the molecular mass 53 kDa. The large VLPs (Dc3nVLPs and Dc4nVLPs) were 35 nm in diameter, and were assembled by a 64-kDa protein. An antigenic analysis demonstrated that DcHEV was cross-reactive with G1, G3-G6, ferret and rat HEVs, and DcHEV showed a stronger cross-reactivity to G1 G3-G6 HEV than it did to rat and ferret HEV. In addition, the antibody against DcHEV-LPs neutralized G1 and G3 HEV in a cell culture system, suggesting that the serotypes of these HEVs are identical. We also found that the amino acid residue Met-358 affects the small DcHEV-LPs assembly. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Comparative pathogenesis in specific-pathogen-free chickens of two strains of avian hepatitis E virus recovered from a chicken with Hepatitis-Splenomegaly syndrome and from a clinically healthy chicken.

    Science.gov (United States)

    Billam, P; LeRoith, T; Pudupakam, R S; Pierson, F W; Duncan, R B; Meng, X J

    2009-11-18

    Avian hepatitis E virus (avian HEV) is the primary causative agent of Hepatitis-Splenomegaly (HS) syndrome in chickens. Recently, a genetically unique strain of avian HEV, designated avian HEV-VA, was recovered from healthy chickens in Virginia. The objective of this study was to experimentally compare the pathogenicity of the prototype strain recovered from a chicken with HS syndrome and the avian HEV-VA strain in specific-pathogen-free chickens. An infectious stock of the avian HEV-VA strain was first generated and its infectivity titer determined in chickens. For the comparative pathogenesis study, 54 chickens of 6-week-old were assigned to 3 groups of 18 chickens each. The group 1 chickens were each intravenously inoculated with 5x10(2.5) 50% chicken infectious dose of the prototype strain. The group 2 received the same dose of the avian HEV-VA strain, and the group 3 served as negative controls. Six chickens from each group were necropsied at 2, 3 and 4 weeks post-inoculation (wpi). Most chickens in both inoculated groups seroconverted by 3wpi, and the mean anti-avian HEV antibody titers were higher for the prototype strain group than the avian HEV-VA strain group. There was no significant difference in the patterns of viremia and fecal virus shedding. Blood analyte profiles did not differ between treatment groups except for serum creatine phosphokinase levels which were higher for prototype avian HEV group than avian HEV-VA group. The hepatic lesion score was higher for the prototype strain group than the other two groups. The results indicated that the avian HEV-VA strain is only slightly attenuated compared to the prototype strain, suggesting that the full spectrum of HS syndrome is likely associated with other co-factors.

  10. Experimental infection of Balb/c nude mice with Hepatitis E virus

    Directory of Open Access Journals (Sweden)

    Zhu Jianguo

    2009-06-01

    Full Text Available Abstract Background Several animal species can reportedly act as reservoirs for Hepatitis E virus (HEV, a zoonotic pathogen. HEV and antibody to the virus have been detected in a variety of animals including rodents. Pig and rat models for HEV have been established for HEV, but a nude mouse has not yet been developed. Methods Balb/c nude mice were inoculated with swine HEV, both orally and via intravenous injection to insure infection. Negative control and experimental contact-exposed groups of mice were also included in the study. The liver, spleen, kidney, jejunum, ileum, cecum and colon of each mouse from all three groups were collected for reverse transcription nested polymerase chain reaction (RT-nPCR detection, indirect immunofluorescence observation and histopathologic examination. The sera from nude mice were tested for anti-HEV IgG by enzyme linked immunosorbent assay (ELISA. Activities of liver enzymes, including alanine aminotransferase (ALT, aspartate aminotransferase (AST and alkaline phosphatase (ALP, as well as total bilirubin (TBIL were also measured in the sera of the nude mice. Results HEV antigens and HEV RNA were detected in liver, spleen, kidney, jejunum, ileum and colon both by indirect immunofluorescence and by RT-nPCR in all of the inoculated and in one of the contact-exposed nude mice. Histopathological changes were observed in the liver and spleen of these mice. Infected mice showed increased levels of AST, ALP, and anti-HEV IgG in sera. The livers of contact-exposed mice showed obvious histopathological damage. Conclusion Nude mice could be readily infected by HEV isolated from pigs. The nude mouse may therefore be a useful animal model for studying the pathogenesis of HEV.

  11. Hepatitis A Virus and Hepatitis E Virus Seroprevalence Among Blood Donors in Tehran, Iran.

    Science.gov (United States)

    Hesamizadeh, Khashayar; Sharafi, Heidar; Keyvani, Hossein; Alavian, Seyed Moayed; Najafi-Tireh Shabankareh, Azar; Sharifi Olyaie, Roghiyeh; Keshvari, Maryam

    2016-01-01

    Hepatitis A virus (HAV) and Hepatitis E virus (HEV) are both transmitted by the fecal-oral route and are known as the leading causes of acute viral hepatitis in the world, especially in developing countries. There is a lack of updated data on HAV and HEV seroprevalence in Iran. The aim of this study was to determine the seroprevalence of HAV and HEV among a group of blood donors in Tehran, Iran. A cross-sectional study was performed from July 2014 to December 2014, on a total of 559 blood donors referred to the Tehran blood transfusion center. The serum samples were tested for antibodies to HAV and HEV, using the enzyme-linked immunosorbent assay. In the present study, 536 (95.9%) cases were male and 23 (4.1%) female with mean age of 38 years. Out of 559 blood donors, 107 (19.1%) were first-time donors, 163 (29.2%) lapsed donors and 289 (51.7%) regular donors. Anti-HAV was found in 395 (70.7%) and anti-HEV in 45 (8.1%) of the blood donors. The HAV and HEV seroprevalence increased by age. There was no significant difference between genders in terms of anti-HAV and anti-HEV status. The HAV and HEV seroprevalence was significantly related to the level of education, where the donors with higher level of education had lower rate of HAV and HEV seroprevalence. The HAV and HEV seroprevalence was significantly higher in regular and lapsed donors than in first-time donors. The present study showed that both HAV and HEV infections are still endemic in Iran.

  12. Hepatitis E virus seroprevalence rate among Eastern Mediterranean and middle eastern countries; A systematic review and pooled analysis.

    Science.gov (United States)

    Karbalaie Niya, Mohammad Hadi; Rezaee-Zavareh, Mohammad Saeid; Ranaei, Alireza; Alavian, Seyed Moayed

    2017-09-01

    Hepatitis E virus (HEV) as a hepatotropic virus is one of the major global health concerns. Autochthonous HEV transmitted by oral fecal-route in poor sanitation conditions as well as vertical and rarely blood transfusion. HEV occurrence is more common in developing countries and recently increased in developed countries too. Middle East (ME) and Eastern Mediterranean region (EMR) of WHO have been an endemic region for HEV infection. In this regard, we aimed to design a systematic review and pooled analysis to determine seroprevalence of anti-HEV antibody in ME and EMR countries. By using PRISMA guideline, data were collected from papers identified through PubMed, Web of Science, Science Direct, Scopus and also from some national and regional databases from January 1990 to June 2016. Serum anti-HEV antibody (IgG) used for HEV prevalence estimation. HEV prevalence in the ME, WHO EMR countries, and in total, calculated by each country population size based on 2015 UN report. overall, 62 papers with a total sample size of 31,673 were fulfilled our eligibility criteria and included in our project. Considering anti-HEV antibody (IgG), prevalence of HEV infection in the countries of ME, WHO EMR and in total were 12.17% (95% CI: 11.79-12.57), 11.81% (95% CI: 11.43-12.21), and 11.87% (95% CI: 11.52-12.23) respectively. HEV seroprevalence in WHO EMR and ME countries has high rate and more considerations are needed for the prevention and control of this infection especially in high-risk groups such as pregnant women. Copyright © 2017. Published by Elsevier Ltd.

  13. Current Knowledge on Hepatitis E.

    Science.gov (United States)

    Pérez-Gracia, María Teresa; García, Mario; Suay, Beatriz; Mateos-Lindemann, María Luisa

    2015-06-28

    Although only a single serotype of hepatitis E virus (HEV), the causative agent of hepatitis E, has been identified, there is great genetic variation among the different HEV isolates reported. There are at least four major recognized genotypes of HEV: genotypes 1 and 2 are mainly restricted to humans and linked to epidemic outbreaks in nonindustrialized countries, whereas genotypes 3 and 4 are zoonotic in both developing and industrialized countries. Besides human strains, genotype 3 and 4 strains of HEV have been genetically characterized from swine, sika deer, mongooses, sheep, and rabbits. Currently, there are approximately 11,000 human and animal sequences of HEV available at the International Nucleotide Sequence Database Collaboration. HEV is the major cause of waterborne outbreaks of hepatitis in areas of poor sanitation. Additionally, it is responsible for sporadic cases of viral hepatitis in not only endemic but industrialized countries as well. Transmission of HEV occurs predominantly by the fecal-oral route, although parenteral and perinatal routes have been reported. HEV infection develops in most individuals as a self-limiting, acute, icteric hepatitis; with mortality rates around 1%. However, some affected individuals will develop fulminant hepatic failure, a serious condition that is frequently fatal without a liver transplant. This complication is particularly common when the infection occurs in pregnant women, where mortality rates rise dramatically to up to 25%. Among the preventive measures available to avoid HEV infection, two separate subunit vaccines containing recombinant truncated capsid proteins of HEV have been shown to be highly effective in the prevention of disease. One of them, HEV 239, was approved in China, and its commercialization by Innovax began in November 2012 under the name Hecolin(®).

  14. Application of Task Time Principle in On-the-scene Logistics Management,a Case Study of the GAC-Toyota Supplies Logistics Center%工时定额原理在现场物流管理中的应用——基于广汽丰田补给品物流中心的案例分析

    Institute of Scientific and Technical Information of China (English)

    肖建辉

    2010-01-01

    以工时定额原理为基础,以广汽丰田补给品物流中心的运作为实例,分析了工时定额原理如何在现场物流管理中具体应用,才能有效解决物流现场的管理难题,达到优化配置资源的目的.

  15. Assessment of Lean Construction Principles: A Case Study at Semarang Medical Centre Hospital Project

    Directory of Open Access Journals (Sweden)

    Matias Roy Adi Wijaya

    2016-06-01

    Full Text Available The lean construction frameworks have been developed for years to enhance the poor performance of Indonesian project delivery system which influenced by the waste of non-value adding activities. Never the less most of the developments were limited on working process and lack in people empowerment. Toyota Way which integrate working process optimization and people empowerment, was developed as a lean construction frame works. This paper aimed to assess the implementation of Toyota Way principles in project delivery system by observing project’s delivery current state (status quo. The assessment began by conducting a questionnaire survey about Toyota Way implementation which then validated by interview with involved stakeholders and field observation. The assessment showed that project’s stakeholders were still unfamiliar with Toyota Way concept. Although some Toyota Way guidelines have been used in projects completion process such as visual management and training program, it found that those guidelines had not fully implemented. The project delivery system was lack of process focus and concerns more on relationship inter-parties. It also found thatToyota Way implementation will constrained by the difficulties to change the status quo of project delivery. Moreover, it seems that construction projects need practical guidelines to simplify the Toyota Way implementation in project delivery system such as project flow evaluation and system of reflection.

  16. Advances in hepatitis E - II: Epidemiology, clinical manifestations, treatment and prevention.

    Science.gov (United States)

    Goel, Amit; Aggarwal, Rakesh

    2016-09-01

    Infection with hepatitis E virus (HEV) is the commonest cause of acute hepatitis worldwide. This infection, with fecal-oral transmission, was previously thought to be limited to humans residing in developing countries with poor sanitation, spreading via contaminated drinking water. In recent years, our understanding of epidemiology and clinical spectrum of this infection have changed markedly. This article reviews the epidemiology, including routes of transmission, and clinical manifestations of HEV infection around the world. In addition, recent findings on transmission-associated HEV infection, extrahepatic manifestations of hepatitis E and chronic infection with HEV, and treatment and prevention of this infection are discussed. Expert commentary: HEV infection has two distinct epidemiologic forms and clinical patterns of disease: (i) acute epidemic or sporadic hepatitis caused by fecal-oral (usually water-borne) transmission of genotype 1 and 2 HEV from a human reservoir in areas with poor hygiene and frequent water contamination, and (ii) infrequent sporadic hepatitis E caused by zoonotic infection, possibly from an animal source through ingestion of undercooked animal meal, of genotype 3 or 4 virus. In disease-endemic areas, pregnant women are at a particular risk of serious disease and high mortality. In less-endemic areas, chronic infection with HEV among immunosuppressed persons is observed. HEV can also be transmitted through Transfusion of blood and blood products. Ribivirin treatment is effective in chronic hepatitis E. Two efficacious vaccines have been tried in humans; one of these has received marketing approval in its country of origin.

  17. [Current dilemmas on the transmission of hepatitis E virus

    NARCIS (Netherlands)

    Jong, E de; Peters, A.M.; Rahamat-Langendoen, J.C.; Blijlevens, N.M.A.

    2017-01-01

    Immunocompromised patients are especially at risk for developing chronic hepatitis E virus (HEV) infection, which may result in progressive liver disease and cirrhosis. In addition, treatment of chronic HEV infection in these patients often includes dose reduction of immunosuppressive therapy and

  18. Prevalence and risk of hepatitis e virus infection in the HIV population of Nepal

    NARCIS (Netherlands)

    Shrestha, A. (Ananta); Adhikari, A. (Anurag); Bhattarai, M. (Manjula); Rauniyar, R. (Ramanuj); J.D. Debes; P.A. Boonstra (André); Lama, T.K. (Thupten K.); Al Mahtab, M. (Mamun); Butt, A.S. (Amna Subhan); Akbar, S.M.F. (Sheikh Mohammad Fazle); Aryal, N. (Nirmal); Karn, S. (Sapana); Manandhar, K.D. (Krishna Das); Gupta, B.P. (Birendra Prasad)

    2017-01-01

    textabstractBackground: Infection with the hepatitis E virus (HEV) can cause acute hepatitis in endemic areas in immune-competent hosts, as well as chronic infection in immune-compromised subjects in non-endemic areas. Most studies assessing HEV infection in HIV-infected populations have been

  19. Increasing Contact with Hepatitis E Virus in Red Deer, Spain

    Science.gov (United States)

    Casas, Maribel; Martín, Marga; Vicente, Joaquín; Segalés, Joaquim; de la Fuente, José; Gortázar, Christian

    2010-01-01

    To describe the epidemiology of hepatitis E virus (HEV) in red deer in mainland Spain, we tested red deer for HEV RNA and antibodies. Overall, 10.4% and 13.6% of serum samples were positive by ELISA and reverse transcription–PCR, respectively. The increasing prevalence suggests a potential risk for humans. PMID:21122241

  20. Porcine blood used as ingredient in meat productions may serve as a vehicle for hepatitis E virus transmission.

    NARCIS (Netherlands)

    Boxman, Ingeborg L A; Jansen, Claudia C C; Hägele, Geke; Zwartkruis-Nahuis, Ans; Cremer, Jeroen; Vennema, Harry; Tijsma, Aloys S L

    2017-01-01

    The aim of the present study was to investigate whether the use of porcine blood(products) in food could be a risk for a hepatitis E virus (HEV) infection. HEV RNA was detected in 33/36 batches of (non-heated) liquid products and in 7/24 spray dried powder products. Contamination levels varied among

  1. Development and testing of a bipolar lead-acid battery for hybrid electric vehicles

    NARCIS (Netherlands)

    Saakes, M.; Kluiters, E.; Schmal, D.; Mourad, S.; Have, P.T.J.H. ten

    1999-01-01

    An 80 V bipolar lead-acid battery was constructed and tested using hybrid electric vehicle (HEV) drive cycles. Drive cycles with a peak power of 6.7 kW, equal to 1/5 of the total power profile required for the HEV studied, were run successfully. Model calculations showed that the 80 V module

  2. Hepatitis E in Children : A Position Paper by the ESPGHAN Hepatology Committee

    NARCIS (Netherlands)

    Fischler, Bjorn; Baumann, Ulrich; Dezsofi, Antal; Hadzic, Nedim; Hierro, Loreto; Jahnel, Jorg; Mclin, Valerie; Nobili, Valerio; Smets, Francoise; Verkade, Henkjan; Debray, Dominique

    Background: Hepatitis E virus (HEV) is endemic in large parts of the developing world. Waterborne transmission of genotypes 1 or 2 commonly causes acute hepatitis, which is usually self-limited in healthy individuals. In addition, acute HEV infections also occur outside endemic areas, mostly related

  3. Töölehed õpiraskustega õpilastele / Inga Kukk

    Index Scriptorium Estoniae

    Kukk, Inga

    2007-01-01

    Projektist "Hariduslike erivajadustega õpilaste õppevara koostajate koolitus". Projekti raames loodud HEV-kodulehest (www.hev.edu.ee), millel on esitletud projektikoolituse käigus koostatud töölehed, kokku 140 töölehte matemaatikas ning 160 töölehte ja PowerPoint-esitlust loodusõpetuses

  4. Transfusion-Transmitted Hepatitis E: NAT Screening of Blood Donations and Infectious Dose.

    Science.gov (United States)

    Dreier, Jens; Knabbe, Cornelius; Vollmer, Tanja

    2018-01-01

    The risk and importance of transfusion-transmitted hepatitis E virus (TT-HEV) infections by contaminated blood products is currently a controversial discussed topic in transfusion medicine. The infectious dose, in particular, remains an unknown quantity. In the present study, we illuminate and review this aspect seen from the viewpoint of a blood donation service with more than 2 years of experience in routine HEV blood donor screening. We systematically review the actual status of presently known cases of TT-HEV infections and available routine NAT-screening assays. The review of the literature revealed a significant variation regarding the infectious dose causing hepatitis E. We also present the outcome of six cases confronted with HEV-contaminated blood products, identified by routine HEV RNA screening of minipools using the highly sensitive RealStar HEV RT-PCR Kit (95% LOD: 4.7 IU/mL). Finally, the distribution of viral RNA in different blood components [plasma, red blood cell concentrate (RBC), platelet concentrates (PC)] was quantified using the first WHO international standard for HEV RNA for NAT-based assays. None of the six patients receiving an HEV-contaminated blood product from five different donors (donor 1: RBC, donor 2-5: APC) developed an acute hepatitis E infection, most likely due to low viral load in donor plasma (donations should be adequate as a routine screening assay to identify high viremic donors and will cover at least a large part of viremic phases.

  5. Hepatitis E Virus in Farmed Rabbits, Wild Rabbits and Petting Farm Rabbits in the Netherlands

    NARCIS (Netherlands)

    Burt, S.A.; Veltman, Jorg; Hakze-van der Honing, Renate; Schmitt, Heike; van der Poel, Wim H.M.

    2016-01-01

    Rabbits have been suggested as a zoonotic source of Hepatitis E virus. Phylogenetic analysis of HEV isolates from farmed, wild and pet rabbits in the Netherlands (23, 0, and 60 % respectively) showed them to be grouped amongst published rabbit HEV sequences and distinct from most human isolates.

  6. Hepatitis E Virus in Farmed Rabbits, Wild Rabbits and Petting Farm Rabbits in the Netherlands

    NARCIS (Netherlands)

    Burt, Sara A.; Veltman, Jorg; Hakze-van der Honing, Renate; Schmitt, Heike; Poel, van der Wim H.M.

    2016-01-01

    Rabbits have been suggested as a zoonotic source of Hepatitis E virus. Phylogenetic analysis of HEV isolates from farmed, wild and pet rabbits in the Netherlands (23, 0, and 60 % respectively) showed them to be grouped amongst published rabbit HEV sequences and distinct from most human isolates.

  7. Hepatitis E virus is highly prevalent in the Danish pig population

    DEFF Research Database (Denmark)

    Breum, Solvej Østergaard; Hjulsager, Charlotte Kristiane; Deus, Nilsa de

    2010-01-01

    The objective of this study was to examine the prevalence of Hepatitis E virus (HEV) in the Danish pig population. Faecal samples from 97 pigs, 1–5 months of age were analysed for HEV RNA by a new PriProET real time RT-PCR assay. In addition, serum samples from 71 sow herds were screened...

  8. Food and environmental routes of Hepatitis E virus transmission

    NARCIS (Netherlands)

    Poel, van der W.H.M.

    2014-01-01

    Abstract Hepatitis E virus (HEV), genus Hepevirus, family hepeviridae is a main cause of epidemic hepatitis in developing countries and single cases of hepatitis in higher income countries. There are at least four HEV genotypes which have different epidemiologic and clinical features. Hepatitis E

  9. Meat consumption is a major risk factor for hepatitis E virus infection

    NARCIS (Netherlands)

    Slot, Ed; Zaaijer, Hans L.; Molier, Michel; van den Hurk, Katja; Prinsze, Femmeke; Hogema, Boris M.

    2017-01-01

    The incidence of autochthonous hepatitis E virus genotype 3 (HEV gt3) infections in Western Europe is high. Although pigs are a major reservoir of the virus, the exact sources and transmission route(s) of HEV gt3 to humans remain unclear. To determine the role of meat consumption at a population

  10. Chronic hepatitis E virus infection in liver transplant recipients

    NARCIS (Netherlands)

    Haagsma, Elizabeth B.; van den Berg, Arie P.; Porte, Robert J.; Benne, Cornelis A.; Vennema, Harry; Reimerink, Johan H. J.; Koopmans, Marion P. G.

    Hepatitis E virus (HEV) infection is known to run a self-limiting course. Sporadic cases of acute hepatitis due to infection with HEV genotype 3, present in pig populations, are increasingly recognized. Zoonotic transmission seems infrequent. The entity of unexplained chronic hepatitis after liver

  11. Hepatitis E virus persists in the presence of a type III interferon response.

    Science.gov (United States)

    Yin, Xin; Li, Xinlei; Ambardekar, Charuta; Hu, Zhimin; Lhomme, Sébastien; Feng, Zongdi

    2017-05-01

    The RIG-I-like RNA helicase (RLR)-mediated interferon (IFN) response plays a pivotal role in the hepatic antiviral immunity. The hepatitis A virus (HAV) and the hepatitis C virus (HCV) counter this response by encoding a viral protease that cleaves the mitochondria antiviral signaling protein (MAVS), a common signaling adaptor for RLRs. However, a third hepatotropic RNA virus, the hepatitis E virus (HEV), does not appear to encode a functional protease yet persists in infected cells. We investigated HEV-induced IFN responses in human hepatoma cells and primary human hepatocytes. HEV infection resulted in persistent virus replication despite poor spread. This was companied by a type III IFN response that upregulated multiple IFN-stimulated genes (ISGs), but type I IFNs were barely detected. Blocking type III IFN production or signaling resulted in reduced ISG expression and enhanced HEV replication. Unlike HAV and HCV, HEV did not cleave MAVS; MAVS protein size, mitochondrial localization, and function remained unaltered in HEV-replicating cells. Depletion of MAVS or MDA5, and to a less extent RIG-I, also diminished IFN production and increased HEV replication. Furthermore, persistent activation of the JAK/STAT signaling rendered infected cells refractory to exogenous IFN treatment, and depletion of MAVS or the receptor for type III IFNs restored the IFN responsiveness. Collectively, these results indicate that unlike other hepatotropic RNA viruses, HEV does not target MAVS and its persistence is associated with continuous production of type III IFNs.

  12. Swine is a possible source of hepatitis E virus infection by comparative study of hepatitis A and E seroprevalence in Thailand.

    Science.gov (United States)

    Sa-nguanmoo, Pattaratida; Posuwan, Nawarat; Vichaiwattana, Preeyaporn; Wutthiratkowit, Norra; Owatanapanich, Somchai; Wasitthankasem, Rujipat; Thongmee, Thanunrat; Poovorawan, Kittiyod; Theamboonlers, Apiradee; Vongpunsawad, Sompong; Poovorawan, Yong

    2015-01-01

    Hepatitis A virus (HAV) and hepatitis E virus (HEV) infection in developing countries are associated with contaminated food or water. Although Thailand is non-endemic for HEV, sporadic infections may occur from zoonotic transmission. Individuals between 7 months to 69 years (mean age = 32.8) from predominantly Islamic Narathiwat (n = 305) and swine farm-dense Lop Buri (n = 416) provinces were screened for anti-HEV and anti-HAV antibodies by commercial enzyme-linked immunosorbent assay and automated chemiluminescent microparticle immunoassay, respectively. Seroprevalence and relative antibody titers were analyzed according to age groups. HAV IgG antibody positive rates in Lop Buri and Narathiwat residents were 39.9% and 58%, respectively (p 50 years old in both provinces possessed anti-HAV IgG. In contrast, seroprevalence for anti-HEV IgG was much higher in Lop Buri (37.3%) than in Narathiwat (8.9%) (p < 0.001). Highest anti-HEV IgG prevalence was found among 21-30 year-olds (50%) in Lop Buri and 41-50 year-olds (14.1%) in Narathiwat. In summary, fewer individuals possessed anti-HEV IgG in Narathiwat where most residents abstained from pork and fewer swine farms are present. Therefore, an increased anti-HEV IgG seroprevalence was associated with the density of swine farm and possibly pork consumption. Adults were more likely than children to have antibodies to both HEV and HAV.

  13. Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt.

    Science.gov (United States)

    Hasan, Gamal; Assiri, Asaad; Marzuuk, Naglaa; Daef, Enas; Abdelwahab, Sayed; Ahmed, Ahmed; Mohamad, Ismail; Al-Eyadhy, Ayman; Alhaboob, Ali; Temsah, Mohamad-Hani

    2016-10-01

    Objective To describe the characteristics of hepatitis E virus (HEV) infection in a cohort of children from Upper Egypt using data from a large multicentre prospective study of acute viral hepatitis (AVH). Methods Data from subjects aged 2-18 years with AVH or close contacts of those with AVH found to have asymptomatic AVH were included in the analysis. Information concerning medical history, clinical examination, liver function tests and screening for hepatotropic viruses was recorded and analysed. Results A total of 123 patients (73 boys, 50 girls) were included in the analysis. Of these, 33 (26.8%) had HEV infection, 17 (13.8%) had hepatitis A virus infection, 10 (8.1%) had hepatitis B virus infection, 14 (11.4%) had cytomegalovirus hepatitis, five (4.1%) had autoimmune hepatitis, 11 (8.9%) had hepatitis due to mixed viral infections and 33 (26.8%) had non A-E hepatitis. Overall, 38 (30.9%) had infection with HEV. HEV infection was significantly higher among those using underground wells as a water source compared with tap water. Liver enzymes were significantly raised in patients with non-HEV infection compared with those with HEV infection. Conclusions HEV is a significant cause of AVH among children in Upper Egypt. Contamination of drinking water appears to be a major source of infection. Screening for HEV should be considered in all Egyptian children with AVH.

  14. Hepatitis E virus infection in North Italy: high seroprevalence in swine herds and increased risk for swine workers.

    NARCIS (Netherlands)

    Mughini-Gras, L; Angeloni, G; Salata, C; Vonesch, N; D'Amico, W; Campagna, G; Natale, A; Zuliani, F; Ceglie, L; Monne, I; Vascellari, M; Capello, K; DI Martino, G; Inglese, N; Palù, G; Tomao, P; Bonfanti, L

    2017-01-01

    We determined the hepatitis E virus (HEV) seroprevalence and detection rate in commercial swine herds in Italy's utmost pig-rich area, and assessed HEV seropositivity risk in humans as a function of occupational exposure to pigs, diet, foreign travel, medical history and hunting activities. During

  15. Hepatitis E virus infection in North Italy : high seroprevalence in swine herds and increased risk for swine workers

    NARCIS (Netherlands)

    Mughini-Gras, L|info:eu-repo/dai/nl/413306046; Angeloni, Giorgia; Salata, C; Vonesch, N; D'Amico, W; Campagna, G; Natale, Alda; Zuliani, Federica; Ceglie, Letizia; Monne, Isabella; Vascellari, M; Capello, Katia; DI Martino, G; Inglese, N; Palù, G; Tomao, P; Bonfanti, L.

    2017-01-01

    We determined the hepatitis E virus (HEV) seroprevalence and detection rate in commercial swine herds in Italy's utmost pig-rich area, and assessed HEV seropositivity risk in humans as a function of occupational exposure to pigs, diet, foreign travel, medical history and hunting activities. During

  16. Molecular detection of hepatitis E virus in feces and slurry from swine farms, Rio Grande do Sul, Southern Brazil

    Directory of Open Access Journals (Sweden)

    J. Vasconcelos

    2015-06-01

    Full Text Available Hepatitis E virus (HEV is highly disseminated among swine herds worldwide. HEV is also a threat to public health, since particularly genotypes 3 and 4 may cause acute hepatitis in human beings. No previous studies were done on the occurrence of HEV in environmental samples in Rio Grande do Sul, Brazil. In the present study, reverse transcriptase-polymerase chain reaction (RT-PCR was employed to detect the presence of HEV in swine feces and in effluents from slurry lagoons in farms located in the municipality of Teutônia, inside the area of swine husbandry in the state. Pooled fecal samples from the floor of pig barns from 9 wean-to-finish farms and liquid manure samples were collected from the slurry lagoons from 8 of these farms. From the pooled fecal samples, 8/9 were positive for the HEV ORF1 gene by RT-PCR; all the slurry lagoon samples were positive for HEV RNA (100%. The identity of the HEV ORF1 amplicons was confirmed by sequencing belonging to HEV genotype 3, which was previously shown to be circulating in South America.

  17. Hepatitis E is a cause of unexplained hepatitis in The Netherlands

    NARCIS (Netherlands)

    Waar, K; Herremans, MMPT; Vennema, H; Koopmans, MPG; Benne, CA

    Background: Hepatitis E virus (HEV) is the major etiologic agent of enterically transmitted viral hepatitis in much of the developing world. Evidence provided in recent years shows that HEV is also prevalent in very low numbers in non-endemic countries. Recently, a cluster of three patients with

  18. cDNA encoding a polypeptide including a hevein sequence

    Energy Technology Data Exchange (ETDEWEB)

    Raikhel, N.V.; Broekaert, W.F.; Namhai Chua; Kush, A.

    1993-02-16

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1,018 nucleotides long and includes an open reading frame of 204 amino acids.

  19. Epidemiology and Risk Factors of Incident Hepatitis E Virus Infections in Rural Bangladesh

    Science.gov (United States)

    Labrique, Alain B.; Zaman, K.; Hossain, Zahid; Saha, Parimalendu; Yunus, Mohammad; Hossain, Anowar; Ticehurst, John R.; Nelson, Kenrad E.

    2010-01-01

    Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis in the world. Most of South Asia is HEV endemic, with frequent seasonal epidemics of hepatitis E and continuous sporadic cases. This author group's epidemiologic work and clinical reports suggest that Bangladesh is HEV endemic, but there have been few population-based studies of this country's HEV burden. The authors calculated HEV infection rates, over an 18-month interval between 2003 and 2005, by following a randomly selected cohort of 1,134 subjects between the ages of 1 and 88 years, representative of rural communities in southern Bangladesh. Baseline prevalence of antibody to hepatitis E virus (anti-HEV) was 22.5%. Seroincidence was 60.3 per 1,000 person-years during the first 12 months and 72.4 per 1,000 person-years from >12 to 18 months (during the monsoon season), peaking by age 50 years and with low rates during childhood. Few of the seroconverting subjects reported hepatitis-like illness. Overall incidence was calculated to be 64 per 1,000 person-years, with 1,172 person-years followed. No significant associations were found between anti-HEV incidence and demographic or socioeconomic factors for which data were available. This is the first study to document annual HEV infection rates among “healthy” and very young to elderly subjects in a rural Bangladeshi population. PMID:20801864

  20. Hepatitis E and blood donation safety in selected European countries

    DEFF Research Database (Denmark)

    Domanović, Dragoslav; Tedder, Richard; Blümel, Johannes

    2017-01-01

    The public health implications of hepatitis E virus (HEV) in Europe have changed due to increasing numbers of hepatitis E cases and recent reports of chronic, persistent HEV infections associated with progression to cirrhosis in immunosuppressed patients. The main infectious risk...