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Sample records for today act trial

  1. Curricular Critique of an Environmental Education Policy Framework: Acting Today, Shaping Tomorrow

    Directory of Open Access Journals (Sweden)

    Douglas D. Karrow

    2015-10-01

    Full Text Available The following paper is a curricular critique of an environmental education policy framework called Acting Today, Shaping Tomorrow (2009. It is founded upon: (a an examination of the conventional argument for integrated curriculum models and its relevance to K-12 environmental education; and (b utilization of a typology of integrated curriculum models to analyze an environmental education policy framework within the jurisdiction of Ontario, Canada. In conclusion, Ontario’s environmental education policy framework tends toward an integrated curriculum model referred to as ‘selective infusion.’  The implications for integrated curricular practice are identified, with recommendations for improving the policy framework from an integrated curricular perspective.     Key Words: environmental education, integrated curriculum, curriculum critique, education policy.

  2. Leadership succession in nursing: thinking and acting today to ensure a better tomorrow

    Directory of Open Access Journals (Sweden)

    Denize Bouttelet Munari

    2017-03-01

    ];7(4:25–9. Available from: http://dx.doi.org/10.1016/j.mnl.2009.05.012. 13. Titzer JL, Shirey MR. Nurse manager succession planning: a concept analysis. Nursing Forum [Internet]. 2013 [cited 2017 mar 27];48(3:155–64. Available from: http://dx.doi.org/10.1111/nuf.12024. 14. Moore LW, Sublett C, Leahy C. Nurse managers' insights regarding their role highlight the need for practice changes. Appl Nurs Res [Internet]. 2016 [cited 2017 mar 27];30:98-103. Available from: http://dx.doi.org/10.1016/j.apnr.2015.11.006. 15. O'Neil E, Morjikian RL, Cherner D, Hirschkorn C, West T. Developing nursing leaders: an overview of trends and programs. J Nurs Adm [Internet]. 2008 [cited 2017 mar 27];38(4:178-83. Available from: http://dx.doi.org/10.1097/01.NNA.0000312754.61170.fa. 16. Stichler J. Succession planning: why grooming their replacements is critical for nurse leaders. Nurs Womens Health [Internet]. 2008 [cited 2017 mar 27];12(6:525-8. Available from: http://dx.doi.org/10.1111/j.1751-486X.2008.00387.x. 17. Vogelsang LE. Early succession planning for nursing faculty. Nurse Educ Today [Internet]. 2014 [cited 2017 mar 27];34(10:1277-9. Available from: http://dx.doi.org/10.1016/j.nedt.2014.05.015. 18. Bolton J, Roy W. Succession planning: securing the future. J Nurs Adm [Internet]. 2004 [cited 2017 mar 27];34(12:589-93. Available from: http://journals.lww.com/jonajournal/Abstract/2004/12000/Succession_Planning__Securing_the_Future.9.aspx. 19. Carriere BK, Muise M, Cummings G, Newburn-Cook C. Healthcare succession planning: an integrative review. J Nurs Adm [Internet]. 2009 [cited 2017 mar 27];39(12:548-55. Available from: http://dx.doi.org/10.1097/NNA.0b013e3181c18010. 20. Redman RW. Leadership succession planning: an evidence-based approach for managing the future. J Nurs Adm [Internet]. 2006 [cited 2017 mar 27];36(6:292-7. Available from: http://journals.lww.com/jonajournal/pages/articleviewer.aspx?year=2006&issue=06000&article=00003&type=abstract. 21. Scully NJ. Leadership in

  3. Retinopathy in youth with type 2 diabetes participating in the TODAY clinical trial

    Science.gov (United States)

    The objective of this study was to determine the prevalence of retinopathy in 517 youth with type 2 diabetes of 2–8 years duration enrolled in the TODAY study. Retinal photographs were graded centrally for retinopathy using established standards. Retinopathy was identified in 13.7% of subjects. Prev...

  4. Parental Characteristics Associated With Outcomes in Youth With Type 2 Diabetes: Results From the TODAY Clinical Trial.

    Science.gov (United States)

    Weinstock, Ruth S; Trief, Paula M; El Ghormli, Laure; Goland, Robin; McKay, Siripoom; Milaszewski, Kerry; Preske, Jeff; Willi, Steven; Yasuda, Patrice M

    2015-05-01

    This study examined parental factors associated with outcomes of youth in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial. Of 699 youth with type 2 diabetes in the TODAY cohort, 623 (89.1%) had a parent participate and provide data at baseline, including weight, HbA1c, blood pressure, symptoms of depression, binge eating (BE), and medical history. Youth were followed 2-6.5 years. Data were analyzed using regression models and survival curve methods. Parental diabetes (43.6% of parents) was associated with higher baseline HbA1c (P parent, P = 0.0002). Parental hypertension (40.6% of parents) was associated with hypertension in youth during TODAY (40.4% vs. 27.4% of youth with and without parental hypertension had hypertension, P = 0.0008) and with higher youth baseline BMI z scores (P = 0.0038). Parents had a mean baseline BMI of 33.6 kg/m(2). Parental obesity (BMI >30 kg/m(2)) was associated with higher baseline BMI z scores in the youth (P parents (20.6% of parents) were related to youth depressive symptoms at baseline only (P = 0.0430); subclinical BE in parents was related to the presence of subclinical BE (P = 0.0354) and depressive symptoms (P = 0.0326) in youth throughout the study period. Parental diabetes and hypertension were associated with lack of glycemic control, hypertension, and higher BMI z scores in youth. Further research is needed to better understand and address parental biological and behavioral factors to improve youth health outcomes. © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

  5. Clinical trials transparency and the Trial and Experimental Studies Transparency (TEST) act.

    Science.gov (United States)

    Logvinov, Ilana

    2014-03-01

    Clinical trial research is the cornerstone for successful advancement of medicine that provides hope for millions of people in the future. Full transparency in clinical trials may allow independent investigators to evaluate study designs, perform additional analysis of data, and potentially eliminate duplicate studies. Current regulatory system and publishers rely on investigators and pharmaceutical industries for complete and accurate reporting of results from completed clinical trials. Legislation seems to be the only way to enforce mandatory disclosure of results. The Trial and Experimental Studies Transparency (TEST) Act of 2012 was introduced to the legislators in the United States to promote greater transparency in research industry. Public safety and advancement of science are the driving forces for the proposed policy change. The TEST Act may benefit the society and researchers; however, there are major concerns with participants' privacy and intellectual property protection. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Heat grids today and after the German Renewable Energies Act (EEG). A business segment for the agriculture?

    International Nuclear Information System (INIS)

    Clemens, Dietrich; Billerbeck, Hagen

    2016-01-01

    The development of a centralised and sustainable heat supply through the construction of heat grids offers consumers numerous advantages compared to a decentralised energy supply of residential and commercial properties. Where the migration to centralised heat supply relegates fossil fuels through the long-term incorporation of sustainable renewable energy sources, the projects make an important contribution towards meeting the government's climate protection goals. Heat generation and heat sales from renewable energy sources should be ensured in the long term. In the countryside, biogas plant operators are frequently the initiators of heat grid investments, or they take on the role of supplier for the provision of low-cost CHP heat from cogeneration units. In view of the limited remuneration period under the terms of the German Renewable Energy Act, the clock is ticking for the establishment of a centralised heat supply. This paper presents the advantages and disadvantages of a centralised, sustainable heat supply and additionally considers the flexibi/isation of biogas plants in view of the construction of the heat grid and the associated infrastructure. A focus is placed on the security of supply for customers after the discontinuation of remuneration under the German Renewable Energy Act and on how a competitive heat price from alternative energy sources can continue to be ensured.

  7. Fibroid interventions: reducing symptoms today and tomorrow: extending generalizability by using a comprehensive cohort design with a randomized controlled trial.

    Science.gov (United States)

    AbdElmagied, Ahmed M; Vaughan, Lisa E; Weaver, Amy L; Laughlin-Tommaso, Shannon K; Hesley, Gina K; Woodrum, David A; Jacoby, Vanessa L; Kohi, Maureen P; Price, Thomas M; Nieves, Angel; Miller, Michael J; Borah, Bijan J; Gorny, Krzysztof R; Leppert, Phyllis C; Lemens, Maureen A; Stewart, Elizabeth A

    2016-09-01

    Uterine fibroids are an important source of morbidity for reproductive-aged women. Despite an increasing number of alternatives, hysterectomies account for about 75% of all fibroid interventional treatments. Evidence is lacking to help women and their health care providers decide among alternatives to hysterectomy. Fibroid Interventions: Reducing Symptoms Today and Tomorrow (NCT00995878, clinicaltrials.gov) is a randomized controlled trial to compare the safety, efficacy, and economics of 2 minimally invasive alternatives to hysterectomy: uterine artery embolization and magnetic resonance imaging-guided focused ultrasound surgery. Although randomized trials provide the highest level of evidence, they have been difficult to conduct in the United States for interventional fibroid treatments. Thus, contemporaneously recruiting women declining randomization may have value as an alternative strategy for comparative effectiveness research. We sought to compare baseline characteristics of randomized participants with nonrandomized participants meeting the same enrollment criteria and to determine whether combining the 2 cohorts in a comprehensive cohort design would be useful for analysis. Premenopausal women with symptomatic uterine fibroids seeking interventional therapy at 3 US academic medical centers were randomized (1:1) in 2 strata based on calculated uterine volume (<700 and ≥700 cc(3)) to undergo embolization or focused ultrasound surgery. Women who met the same inclusion criteria but declined randomization were offered enrollment in a parallel cohort. Both cohorts were followed up for a maximum of 36 months after treatment. The measures addressed in this report were baseline demographics, symptoms, fibroid and uterine characteristics, and scores on validated quality-of-life measures. Of 723 women screened, 57 were randomized and 49 underwent treatment (27 with focused ultrasound and 22 with embolization). Seven of the 8 women randomized but not treated were

  8. Fermilab Today

    Science.gov (United States)

    registration due today Women's Initiative: "Guiltless: Work/Life Balance" - Aug. 13 Nominations for ; -Leah Hesla In Brief Women's Initiative presents 'Guiltless: Work-Life Balance' - Thursday in One West Cowperthwaite-O'Hagan present "Guiltless: Work-Life Balance" on Thursday, Aug. 13, at 3 p.m. in One

  9. Einstein today

    International Nuclear Information System (INIS)

    Aspect, A.; Grangier, Ph.; Bouchet, F.R.; Brunet, E.; Derrida, B.; Cohen-Tannoudji, C.; Dalibard, J.; Laloe, F.; Damour, Th.; Darrigol, O.; Pocholle, J.P.

    2005-01-01

    The most important contributions of Einstein involve 5 fields of physics : the existence of quanta (light quanta, stimulated radiation emission and Bose-Einstein condensation), relativity, fluctuations (Brownian motion and thermodynamical fluctuations), the basis of quantum physics and cosmology (cosmological constant and the expansion of the universe). Diverse and renowned physicists have appreciated the development of modern physics from Einstein's ideas to the knowledge of today. This book is a collective book that gathers their work under 7 chapters: 1) 1905, a new beginning; 2) from the Einstein, Podolsky and Rosen's article to quantum information (cryptography and quantum computers); 3) the Bose-Einstein condensation in gases; 4) from stimulated emission to the today's lasers; 5) Brownian motion and the fluctuation-dissipation theory; 6) general relativity; and 7) cosmology. (A.C.)

  10. Radiochemistry - today

    International Nuclear Information System (INIS)

    Drawe, H.

    1980-01-01

    After a longer starting period many radiation techniques have prevailed practically. Today radiation processes are usual components of chemistry, biology, medicine, and technologies in the most common sense. This paper deals with the latest state of radiation chemistry, whereas the possible practical applications are in the foreground of discussion as to reach mainly practicians in laboratory and industry. But also physicians, pharmacists and chemical engineers should be informed about the possibilities of application of high energyy radiation. Because radiation chemistry has also enriched works of related subjects, for example physical, organic and inorganic chemistry, this paper will also be of interest for experts of these disciplines. (orig.) [de

  11. Neutrinos today

    International Nuclear Information System (INIS)

    Pontecorvo, B.; Bilen'kij, S.

    1987-01-01

    After the famous 1983 discovery of intermediate W, Z 0 bosons it may be stated with certainty that W, Z 0 are entirely responsible for the production of neutrinos and for their interactions. Neutrino physics notions are presented from this point of view in the first four introductory, quite elementary, paragraphs of the paper. The following seven paragraphs are more sophisticated. They are devoted to the neutrino mass and neutrino mixing question, which is the most actual problem in today neutrino physics. Vacuum neutrino oscillations, matter neutrino oscillations and netrinoless double-decay are considered. Solar neutrino physics is discussed in some detail from the point of view of vacuum and matter neutrino oscillations. The role played by neutrinos in the Universe is briefly considered. In the last paragraph there discussed the probable observation by different groups of neutrinos connected with the Supernova 1987 A: the first observation of gravitational star collapse (at least the general rehearsal of such observation) opens up a new era in astronomy of today exerimental physics and astrophysics is presented at the end of the paper in the form of a Table

  12. Psychoanalysis today

    Science.gov (United States)

    FONAGY, PETER

    2003-01-01

    The paper discusses the precarious position of psychoanalysis, a therapeutic approach which historically has defined itself by freedom from constraint and counted treatment length not in terms of number of sessions but in terms of years, in today's era of empirically validated treatments and brief structured interventions. The evidence that exists for the effectiveness of psychoanalysis as a treatment for psychological disorder is reviewed. The evidence base is significant and growing, but less than might meet criteria for an empirically based therapy. The author goes on to argue that the absence of evidence may be symptomatic of the epistemic difficulties that psychoanalysis faces in the context of 21st century psychiatry, and examines some of the philosophical problems faced by psychoanalysis as a model of the mind. Finally some changes necessary in order to ensure a future for psychoanalysis and psychoanalytic therapies within psychiatry are suggested. PMID:16946899

  13. Feminism today

    OpenAIRE

    Subhani, Muhammad Imtiaz; Osman, Ms. Amber

    2012-01-01

    Feminism has been noticed at various stages of time and still is unnoticed. The acts of sexism are apparently at large and only dialogues are delivered without any prompt action. This paper highlights the stage of feminism now and its prospects for the better. This topic talks about women from all walks of life and their thirst of justified identity. One has to develop in the conscious of mankind that women are equal to man and their suppleness to adapt to the environment does not give a sign...

  14. Comparing focused ultrasound and uterine artery embolization for uterine fibroids – Rationale and Design of the Fibroid Interventions: Reducing Symptoms Today and Tomorrow (FIRSTT) trial

    Science.gov (United States)

    Bouwsma, Esther V.A.; Hesley, Gina K.; Woodrum, David A.; Weaver, Amy L.; Leppert, Phyllis C.; Peterson, Lisa G.; Stewart, Elizabeth A.

    2011-01-01

    Objective To present the rational, design and methodology of the FIRSTT study (Fibroid Interventions: Reducing Symptoms Today and Tomorrow, NCT00995878, clinicaltrials.gov). Design Randomized Clinical Trial (RCT) Setting Two Academic Medical Centers Patient(s) Premenopausal women with symptomatic uterine fibroids. Intervention(s) Participants are randomized to two FDA-approved minimally invasive treatments for uterine leiomyomas: uterine artery embolization (UAE) and MRI guided focused ultrasound (MRgFUS). Main Outcome Measure(s) The primary endpoint is defined as the need for an additional intervention for fibroid symptoms following treatment. Secondary outcomes consist of group differences in symptom alleviation, recovery trajectory, health related quality of life, impairment of ovarian reserve, treatment complications and the economic impact of these issues. Results The trial is currently in the phase of active recruitment. Conclusions This RCT will provide important evidence-based information for patients and health care providers regarding optimal minimally invasive treatment approach for women with symptomatic uterine leiomyomas. PMID:21794858

  15. Formative process evaluation for implementing a social marketing intervention to increase walking among African Americans in the Positive Action for Today's Health trial.

    Science.gov (United States)

    Coulon, Sandra M; Wilson, Dawn K; Griffin, Sarah; St George, Sara M; Alia, Kassandra A; Trumpeter, Nevelyn N; Wandersman, Abraham K; Forthofer, Melinda; Robinson, Shamika; Gadson, Barney

    2012-12-01

    Evaluating programs targeting physical activity may help to reduce disparate rates of obesity among African Americans. We report formative process evaluation methods and implementation dose, fidelity, and reach in the Positive Action for Today's Health trial. We applied evaluation methods based on an ecological framework in 2 community-based police-patrolled walking programs targeting access and safety in underserved African American communities. One program also targeted social connectedness and motivation to walk using a social marketing approach. Process data were systematically collected from baseline to 12 months. Adequate implementation dose was achieved, with fidelity achieved but less stable in both programs. Monthly walkers increased to 424 in the walking-plus-social marketing program, indicating expanding program reach, in contrast to no increase in the walking-only program. Increased reach was correlated with peer-led Pride Strides (r = .92; P social marketing component, and program social interaction was the primary reason for which walkers reported participating. Formative process evaluation demonstrated that the walking programs were effectively implemented and that social marketing increased walking and perceived social connectedness in African American communities.

  16. Design of the Xylitol for Adult Caries Trial (X-ACT

    Directory of Open Access Journals (Sweden)

    Amaechi Bennett T

    2010-09-01

    Full Text Available Abstract Background Dental caries incidence in adults is similar to that in children and adolescents, but few caries preventive agents have been evaluated for effectiveness in adults populations. In addition, dentists direct fewer preventive services to their adult patients. Xylitol, an over-the-counter sweetener, has shown some potential as a caries preventive agent, but the evidence for its effectiveness is not yet conclusive and is based largely on studies in child populations. Methods/Design X-ACT is a three-year, multi-center, placebo controlled, double-blind, randomized clinical trial that tests the effects of daily use of xylitol lozenges versus placebo lozenges on the prevention of adult caries. The trial has randomized 691 participants (ages 21-80 to the two arms. The primary outcome is the increment of cavitated lesions. Discussion This trial should help resolve the overall issue of the effectiveness of xylitol in preventing caries by contributing evidence with a low risk of bias. Just as importantly, the trial will provide much-needed information about the effectiveness of a promising caries prevention agent in adults. An effective xylitol-based caries prevention intervention would represent an easily disseminated method to extend caries prevention to individuals not receiving caries preventive treatment in the dental office. Trial Registration ClinicalTrials.Gov NCT00393055

  17. Heat grids today and after the German Renewable Energies Act (EEG). A business segment for the agriculture?; Waermenetze heute und nach dem EEG. Ein Betriebszweig fuer die Landwirtschaft?

    Energy Technology Data Exchange (ETDEWEB)

    Clemens, Dietrich; Billerbeck, Hagen [Treurat und Partner Unternehmensberatungsgesellschaft mbH, Lueneburg (Germany). Abt. ' ' Climate and Energy' '

    2016-08-01

    The development of a centralised and sustainable heat supply through the construction of heat grids offers consumers numerous advantages compared to a decentralised energy supply of residential and commercial properties. Where the migration to centralised heat supply relegates fossil fuels through the long-term incorporation of sustainable renewable energy sources, the projects make an important contribution towards meeting the government's climate protection goals. Heat generation and heat sales from renewable energy sources should be ensured in the long term. In the countryside, biogas plant operators are frequently the initiators of heat grid investments, or they take on the role of supplier for the provision of low-cost CHP heat from cogeneration units. In view of the limited remuneration period under the terms of the German Renewable Energy Act, the clock is ticking for the establishment of a centralised heat supply. This paper presents the advantages and disadvantages of a centralised, sustainable heat supply and additionally considers the flexibi/isation of biogas plants in view of the construction of the heat grid and the associated infrastructure. A focus is placed on the security of supply for customers after the discontinuation of remuneration under the German Renewable Energy Act and on how a competitive heat price from alternative energy sources can continue to be ensured.

  18. The Anticoagulation of Calf Thrombosis (ACT project: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Horner Daniel

    2012-04-01

    Full Text Available Abstract Background Half of all lower limb deep vein thrombi (DVT in symptomatic ambulatory patients are located in the distal (calf veins. While proximal disease warrants therapeutic anticoagulation to reduce the associated risks, distal DVT often goes untreated. However, a proportion of untreated distal disease will undoubtedly propagate or embolize. Concern also exists that untreated disease could lead to long-term post thrombotic changes. Currently, it is not possible to predict which distal thrombi will develop such complications. Whether these potential risks outweigh those associated with unrestricted anticoagulation remains unclear. The Anticoagulation of Calf Thrombosis (ACT trial aims to compare therapeutic anticoagulation against conservative management for patients with acute symptomatic distal deep vein thrombosis. Methods ACT is a pragmatic, open-label, randomized controlled trial. Adult patients diagnosed with acute distal DVT will be allocated to either therapeutic anticoagulation or conservative management. All patients will undergo 3 months of clinical and assessor blinded sonographic follow-up, followed by 2-year final review. The project will commence initially as an external pilot study, recruiting over a 16-month period at a single center to assess feasibility measures and clinical event rates. Primary outcome measures will assess feasibility endpoints. Secondary clinical outcomes will be collected to gather accurate data for the design of a definitive clinical trial and will include: (1 a composite endpoint combining thrombus propagation to the popliteal vein or above, development of symptomatic pulmonary embolism or sudden death attributable to venous thromboembolic disease; (2 the incidence of major and minor bleeding episodes; (3 the incidence of post-thrombotic leg syndrome at 2 years using a validated screening tool; and (4 the incidence of venous thromboembolism (VTE recurrence at 2 years. Discussion The ACT trial

  19. Design and rationale of the Procalcitonin Antibiotic Consensus Trial (ProACT), a multicenter randomized trial of procalcitonin antibiotic guidance in lower respiratory tract infection.

    Science.gov (United States)

    Huang, David T; Angus, Derek C; Chang, Chung-Chou H; Doi, Yohei; Fine, Michael J; Kellum, John A; Peck-Palmer, Octavia M; Pike, Francis; Weissfeld, Lisa A; Yabes, Jonathan; Yealy, Donald M

    2017-08-29

    Overuse of antibiotics is a major public health problem, contributing to growing antibiotic resistance. Procalcitonin has been reported to be commonly elevated in bacterial, but not viral infection. Multiple European trials found procalcitonin-guided care reduced antibiotic use in lower respiratory tract infection, with no apparent harm. However, applicability to US practice is limited due to trial design features impractical in the US, between-country differences, and residual safety concerns. The Procalcitonin Antibiotic Consensus Trial (ProACT) is a multicenter randomized trial to determine the impact of a procalcitonin antibiotic prescribing guideline, implemented with basic reproducible strategies, in US patients with lower respiratory tract infection. We describe the trial methods using the Consolidated Standards of Reporting Trials (CONSORT) framework, and the rationale for key design decisions, including choice of eligibility criteria, choice of control arm, and approach to guideline implementation. ClinicalTrials.gov NCT02130986 . Registered May 1, 2014.

  20. Flue gas conditioning today

    Energy Technology Data Exchange (ETDEWEB)

    Southam, B.J.; Coe, E.L. Jr. [Wahlco Engineering International Ltd., Santa Ana, CA (United States)

    1995-12-01

    Many relatively small electrostatic precipitators (ESP`s) exist which collect fly ash at remarkably high efficiencies and have been tested consistently at correspondingly high migration velocities. But the majority of the world`s coal supplies produce ashes which are collected at much lower migration velocities for a given efficiency and therefore require correspondingly large specific collection areas to achieve acceptable results. Early trials of flue gas conditioning (FGC) showed benefits in maximizing ESP performance and minimizing expense which justified continued experimentation. Trials of several dozen ways of doing it wrong eventually developed a set of reliable rules for doing it right. One result is that the use of sulfur trioxide (SO{sub 3}) for adjustment of the resistivity of fly ash from low sulfur coal has been widely applied and has become an automatically accepted part of the option of burning low sulfur coal for compliance with the Clean Air Act of l990 in the U.S.A. Currently, over 100,000 MW of generating capacity is using FGC, and it is estimated that approximately 45,800 MW will utilize coal-switching with FGC for Clean Air Act emission compliance. Guarantees that this equipment will be available to operate at least 98 percent of the time it is called upon are routinely fulfilled.

  1. Long-acting reversible contraceptive acceptability and unintended pregnancy among women presenting for short-acting methods: a randomized patient preference trial.

    Science.gov (United States)

    Hubacher, David; Spector, Hannah; Monteith, Charles; Chen, Pai-Lien; Hart, Catherine

    2017-02-01

    Measures of contraceptive effectiveness combine technology and user-related factors. Observational studies show higher effectiveness of long-acting reversible contraception compared with short-acting reversible contraception. Women who choose long-acting reversible contraception may differ in key ways from women who choose short-acting reversible contraception, and it may be these differences that are responsible for the high effectiveness of long-acting reversible contraception. Wider use of long-acting reversible contraception is recommended, but scientific evidence of acceptability and successful use is lacking in a population that typically opts for short-acting methods. The objective of the study was to reduce bias in measuring contraceptive effectiveness and better isolate the independent role that long-acting reversible contraception has in preventing unintended pregnancy relative to short-acting reversible contraception. We conducted a partially randomized patient preference trial and recruited women aged 18-29 years who were seeking a short-acting method (pills or injectable). Participants who agreed to randomization were assigned to 1 of 2 categories: long-acting reversible contraception or short-acting reversible contraception. Women who declined randomization but agreed to follow-up in the observational cohort chose their preferred method. Under randomization, participants chose a specific method in the category and received it for free, whereas participants in the preference cohort paid for the contraception in their usual fashion. Participants were followed up prospectively to measure primary outcomes of method continuation and unintended pregnancy at 12 months. Kaplan-Meier techniques were used to estimate method continuation probabilities. Intent-to-treat principles were applied after method initiation for comparing incidence of unintended pregnancy. We also measured acceptability in terms of level of happiness with the products. Of the 916

  2. Insurance denials for cancer clinical trial participation after the Affordable Care Act mandate.

    Science.gov (United States)

    Mackay, Christine B; Antonelli, Kaitlyn R; Bruinooge, Suanna S; Saint Onge, Jarron M; Ellis, Shellie D

    2017-08-01

    The Affordable Care Act (ACA) includes a mandate requiring most private health insurers to cover routine patient care costs for cancer clinical trial participation; however, the impact of this provision on cancer centers' efforts to accrue patients to clinical trials has not been well described. First, members of cancer research centers and community-based institutions (n = 252) were surveyed to assess the status of insurance denials, and then, a focused survey (n = 77) collected denial details. Univariate and multivariate analyses were used to examine associations between the receipt of denials and site characteristics. Overall, 62.7% of the initial survey respondents reported at least 1 insurance denial during 2014. Sites using a precertification process were 3.04 times more likely to experience denials (95% confidence interval, 1.55-5.99; P ≤ .001), and similar rates of denials were reported from sites located in states with preexisting clinical trial coverage laws versus states without them (82.3% vs 85.1%; χ = 50.7; P ≤ .001). Among the focused survey sites, academic centers reported denials more often than community sites (71.4% vs 46.4%). The failure of plans to cover trial participation was cited as the most common reason provided for denials (n = 33 [80.5%]), with nearly 80% of sites (n = 61) not receiving a coverage response from the insurer within 72 hours. Despite the ACA's mandate for most insurers to cover routine care costs for cancer clinical trial participation, denials and delays continue. Denials may continue because some insurers remain exempt from the law, or they may signal an implementation failure. Delays in coverage may affect patient participation in trials. Additional efforts to eliminate this barrier will be needed to achieve federal initiatives to double the pace of cancer research over the next 5 years. Future work should assess the law's effectiveness at the patient level to inform these efforts

  3. The Brooks Act, Is it Relevant Today?

    Science.gov (United States)

    1994-06-01

    Publishing Company, 1990. 7. Fla=., Kenneth. Creatina The ComDuter. Washington, D.C.: The Brookings Institution, 1988. 8. Gilchrist, Bruce, & Wessel...Milton R. Reaulation of the Computer Industry. Montvale: AFIPS Press, 1972. 9. Gore, Al. Creatina A Government That Works Better & Cost Less: Renort

  4. Results from the Xylitol for Adult Caries Trial (X-ACT)

    Science.gov (United States)

    Bader, James D.; Vollmer, William M.; Shugars, Daniel A.; Gilbert, Gregg H.; Amaechi, Bennett T.; Brown, John P.; Laws, Reesa L.; Funkhouser, Kimberly A.; Makhija, Sonia K.; Ritter, André V.; Leo, Michael C.

    2013-01-01

    Background Although caries is prevalent in adults, few preventive therapies have been tested in adult populations. This randomized clinical trial evaluated the effectiveness of xylitol lozenges in preventing caries in elevated caries-risk adults. Methods X-ACT was a three-site placebo-controlled randomized trial. Participants (n=691) ages 21–80 consumed five 1.0 g xylitol or placebo lozenges daily for 33 months. Clinical examinations occurred at baseline, 12, 24 and 33 months. Results Xylitol lozenges reduced the caries increment 11%. This reduction, which represented less than one-third of a surface per year, was not statistically significant. There was no indication of a dose-response effect. Conclusions Daily use of xylitol lozenges did not result in a statistically or clinically significant reduction in 33-month caries increment among elevated caries-risk adults. Clinical Implications These results suggest that xylitol used as a supplement in adults does not significantly reduce their caries experience. PMID:23283923

  5. House of tomorrow today

    NARCIS (Netherlands)

    Lichtenberg, J.J.N.; Ham, M.; Hensen, J.L.M.

    2011-01-01

    The House of Tomorrow Today is a project focussing on a healthy, energy producing dwelling to be realized with today¿s proven technology. The project aims at an energy plus level based on the principles as formulated in SmartBuilding (Slimbouwen) [1] ActiveHouse [2] and HoTT [3] It can be seen as

  6. Physician and patient benefit–risk preferences from two randomized long-acting injectable antipsychotic trials

    Directory of Open Access Journals (Sweden)

    Katz EG

    2016-10-01

    Full Text Available Eva G Katz,1 Brett Hauber,2 Srihari Gopal,3 Angie Fairchild,2 Amy Pugh,4 Rachel B Weinstein,3 Bennett S Levitan3 1Janssen Research & Development, LLC, Raritan, NJ, 2RTI Health Solutions, Research Triangle Park, NC, 3Janssen Research & Development, LLC, Titusville, NJ, 4The University of California, San Francisco (UCSF, CA, USA Purpose: To quantify clinical trial participants’ and investigators’ judgments with respect to the relative importance of efficacy and safety attributes of antipsychotic treatments for schizophrenia, and to assess the impact of formulation and adherence.Methods: Discrete-choice experiment surveys were completed by patients with schizophrenia and physician investigators participating in two phase-3 clinical trials of paliperidone palmitate 3-month long-acting injectable (LAI antipsychotic. Respondents were asked to choose between hypothetical antipsychotic profiles defined by efficacy, safety, and mode of administration. Data were analyzed using random-parameters logit and probit models.Results: Patients (N=214 and physicians (N=438 preferred complete improvement in positive symptoms (severe to none as the most important attribute, compared with improvement in any other attribute studied. Both respondents preferred 3-month and 1-month injectables to oral formulation (P<0.05, irrespective of prior adherence to oral antipsychotic treatment, with physicians showing greater preference for a 3-month over a 1-month LAI for nonadherent patients. Physicians were willing to accept treatments with reduced efficacy for patients with prior poor adherence. The maximum decrease in efficacy (95% confidence interval [CI] that physicians would accept for switching a patient from daily oral to 3-month injectable was as follows: adherent: 9.8% (95% CI: 7.2–12.4, 20% nonadherent: 25.4% (95% CI: 21.0–29.9, and 50% nonadherent: >30%. For patients, adherent: 10.1% (95% CI: 6.1–14.1, nonadherent: the change in efficacy studied was

  7. Academic librarianship today

    CERN Document Server

    2017-01-01

    Intended for use by both librarians and students in LIS programs, Academic Librarianship Today is the most current, comprehensive overview of the field available today. Key features include: Each chapter was commissioned specifically for this new book, and the authors are highly regarded academic librarians or library school faculty— or both Cutting-edge topics such as open access, copyright, digital curation and preservation, emerging technologies, new roles for academic librarians, cooperative collection development and resource sharing, and patron-driven acquisitions are explored in depth Each chapter ends with thought-provoking questions for discussion and carefully constructed assignments that faculty can assign or adapt for their courses The book begins with Gilman’s introduction, an overview that briefly synthesizes the contents of the contributors’ chapters by highlighting major themes. The main part of the book is organized into three parts: The Academic Library Landscape Today, ...

  8. Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial.

    Science.gov (United States)

    Byakika-Kibwika, Pauline; Achan, Jane; Lamorde, Mohammed; Karera-Gonahasa, Carine; Kiragga, Agnes N; Mayanja-Kizza, Harriet; Kiwanuka, Noah; Nsobya, Sam; Talisuna, Ambrose O; Merry, Concepta

    2017-12-28

    Severe malaria is a medical emergency associated with high mortality. Adequate treatment requires initial parenteral therapy for fast parasite clearance followed by longer acting oral antimalarial drugs for cure and prevention of recrudescence. In a randomized controlled clinical trial, we evaluated the 42-day parasitological outcomes of severe malaria treatment with intravenous artesunate (AS) or intravenous quinine (QNN) followed by oral artemisinin based combination therapy (ACT) in children living in a high malaria transmission setting in Eastern Uganda. We enrolled 300 participants and all were included in the intention to treat analysis. Baseline characteristics were similar across treatment arms. The median and interquartile range for number of days from baseline to parasite clearance was significantly lower among participants who received intravenous AS (2 (1-2) vs 3 (2-3), P malaria symptoms. In this high transmission setting, we observed adequate initial treatment outcomes followed by very high rates of malaria re-infection post severe malaria treatment. The impact of recurrent antimalarial treatment on the long term efficacy of antimalarial regimens needs to be investigated and surveillance mechanisms for resistance markers established since recurrent malaria infections are likely to be exposed to sub-therapeutic drug concentrations. More strategies for prevention of recurrent malaria infections in the most at risk populations are needed. The study was registered with the Pan African Clinical Trial Registry ( PACTR201110000321348 ).

  9. The role of motivation in understanding social contextual influences on physical activity in underserved adolescents in the ACT Trial: a cross-sectional study.

    Science.gov (United States)

    Lawman, Hannah G; Wilson, Dawn K; Van Horn, M Lee; Zarrett, Nicole

    2012-12-01

    Previous research has shown that social contextual factors are important in understanding physical activity (PA) behavior, although little is known about how these factors may relate to PA, especially in underserved adolescents (low income, minorities). This study examined how motivation may differentially mediate the relationship of two social contextual variables (i.e., peer and parent social support) and moderate-to-vigorous PA (MVPA). Baseline data (n = 1421 sixth graders, 54% female, 72% African American) from the Active by Choice Today (ACT) trial in underserved adolescents were analyzed. Motivation was examined as a mediator of the relationships between peer social support, parent social support, and MVPA (measured by 7-day accelerometer estimates). Motivation and peer but not parent support were significantly related to MVPA overall. Significant mediation effects were found indicating motivation partially mediated the relation between peer social support and MVPA and to a lesser degree parent support and MVPA. These findings provide support for the importance of social contextual influences, especially peer social support, on underserved adolescents' PA and motivation for PA.

  10. Mathematics Teaching Today

    Science.gov (United States)

    Martin, Tami S.; Speer, William R.

    2009-01-01

    This article describes features, consistent messages, and new components of "Mathematics Teaching Today: Improving Practice, Improving Student Learning" (NCTM 2007), an updated edition of "Professional Standards for Teaching Mathematics" (NCTM 1991). The new book describes aspects of high-quality mathematics teaching; offers a model for observing,…

  11. The Alchemist of Today

    Science.gov (United States)

    Serret, Natasha

    2010-01-01

    Traditionally, alchemy has involved the power of transmuting base metals such as lead into gold or producing the "elixir of life" for those wealthy people who wanted to live forever. But what of today's developments? One hundred years ago, even breaking the four-minute mile would have been deemed "magic," which is what the alchemists of the past…

  12. Preface: Catalysis Today

    DEFF Research Database (Denmark)

    Li, Yongdan

    2016-01-01

    This special issue of Catalysis Today with the theme “Sustain-able Energy” results from a great success of the session “Catalytic Technologies Accelerating the Establishment of Sustainable and Clean Energy”, one of the two sessions of the 1st International Symposium on Catalytic Science and Techn...

  13. Educational Entrepreneurship Today

    Science.gov (United States)

    Hess, Frederick M., Ed.; McShane, Michael Q., Ed.

    2016-01-01

    In "Educational Entrepreneurship Today", Frederick M. Hess and Michael Q. McShane assemble a diverse lineup of high-profile contributors to examine the contexts in which new initiatives in education are taking shape. They inquire into the impact of entrepreneurship on the larger field--including the development and deployment of new…

  14. Building Tomorrow's Business Today

    Science.gov (United States)

    Ryan, Jim

    2010-01-01

    Modern automobile maintenance, like most skilled-trades jobs, is more than simple nuts and bolts. Today, skilled-trades jobs might mean hydraulics, computerized monitoring equipment, electronic blueprints, even lasers. As chief executive officer of Grainger, a business-to-business maintenance, repair, and operating supplies company that…

  15. Packaging Printing Today

    OpenAIRE

    Stanislav Bolanča; Igor Majnarić; Kristijan Golubović

    2015-01-01

    Printing packaging covers today about 50% of all the printing products. Among the printing products there are printing on labels, printing on flexible packaging, printing on folding boxes, printing on the boxes of corrugated board, printing on glass packaging, synthetic and metal ones. The mentioned packaging are printed in flexo printing technique, offset printing technique, intaglio halftone process, silk – screen printing, ink ball printing, digital printing and hybrid printing process. T...

  16. Today's markets for superconductivity

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    The worldwide market for superconductive products may exceed $1 billion in 1987. These products are expanding the frontiers of science, revolutionizing the art of medical diagnosis, and developing the energy technology of the future. In general, today's customers for superconductive equipment want the highest possible performance, almost regardless of cost. The products operate within a few degrees of absolute zero, and virtually all are fabricated from niobium or niobium alloys-so far the high-temperature superconductors discovered in 1986 and 1987 have had no impact on these markets. The industry shows potential and profound societal impact, even without the new materials

  17. Man and electrotechnics today

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    Man and electrotechnique today - this topic was discussed by experts of the VDE (Society of German Electrotechnicians) during a podium discussion directed by the TV-journalist Ruediger Proske. The discussion was centred on the popular questions of energy supply, electronics and the technical communication systems. What are the technologies' influences on our society, how can the social results for the places of employment be estimated and what role is played here by the technicians, the industry and by economy. In the debate which was partly very heated the members showed their anxiety of the negative attitude which society has been developing towards technique to cause big problems for the future.

  18. Man and electrotechnics today

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    Man and electrotechnique today - this topic was discussed by experts of the VDE (Society of German Electrotechnicians) during a podium discussion directed by the TV-journalist Ruediger Proske. The discussion was centred on the popular questions of energy supply, electronics and the technical communication systems. What are the technologies' influences on our society, how can the social results for the places of employment be estimated and what role is played here by the technicians, the industry and by economy. In the debate which was partly very heated the members showed their anxiety of the negative attitude which society has been developing towards technique to cause big problems for the future. (orig.) [de

  19. The Mental Health Care Act No 17 – South Africa. Trials and triumphs

    African Journals Online (AJOL)

    This paper will describe the impact of the Act on mental health care service delivery in ... basic principles of community psychiatry as well as .... allocation, mental health policy, quality assurance and ... Community psychiatry: An audit of the.

  20. Reducing falls among older people in general practice: The ProAct65+ exercise intervention trial.

    Science.gov (United States)

    Gawler, S; Skelton, D A; Dinan-Young, S; Masud, T; Morris, R W; Griffin, M; Kendrick, D; Iliffe, S

    2016-01-01

    Falls are common in the older UK population and associated costs to the NHS are high. Systematic reviews suggest that home exercise and group-based exercise interventions, which focus on progressively challenging balance and increasing strength, can reduce up to 42% of falls in those with a history of falls. The evidence is less clear for those older adults who are currently at low risk of falls. ProAct65+, a large, cluster-randomised, controlled trial, investigated the effectiveness of a home exercise programme (Otago Exercise Programme (OEP)) and a group-based exercise programme (Falls Management Exercise (FaME)) compared to usual care (UC) at increasing moderate to vigorous physical activity (MVPA). This paper examines the trial's secondary outcomes; the effectiveness of the interventions at reducing falls and falls-related injuries. 1256 community-dwelling older adults (aged 65+) were recruited through GP practices in two sites (London and Nottingham). Frequent fallers (≥3 falls in last year) and those with unstable medical conditions were excluded, as were those already reaching the UK Government recommended levels of physical activity (PA) for health. Baseline assessment (including assessment of health, function and previous falls) occurred before randomisation; the intervention period lasted 24 weeks and there was an immediate post-intervention assessment; participants were followed up every six months for 24 months. Falls data were analysed using negative binomial modelling. Falls data were collected prospectively during the intervention period by 4-weekly diaries (6 in total). Falls recall was recorded at the 3-monthly follow-ups for a total of 24 months. Balance was measured at baseline and at the end of the intervention period using the Timed Up & Go and Functional Reach tests. Balance confidence (CONFbal), falls risk (FRAT) and falls self-efficacy (FES-I) were measured by questionnaire at baseline and at all subsequent assessment points. 294

  1. Nuclear energy today

    International Nuclear Information System (INIS)

    2003-01-01

    Energy is the power of the world's economies, whose appetite for this commodity is increasing as the leading economies expand and developing economies grow. How to provide the energy demanded while protecting our environment and conserving natural resources is a vital question facing us today. Many parts of our society are debating how to power the future and whether nuclear energy should play a role. Nuclear energy is a complex technology with serious issues and a controversial past. Yet it also has the potential to provide considerable benefits. In pondering the future of this imposing technology, people want to know. - How safe is nuclear energy? - Is nuclear energy economically competitive? - What role can nuclear energy play in meeting greenhouse gas reduction targets? - What can be done with the radioactive waste it generates? - Does its use increase the risk of proliferation of nuclear weapons? - Are there sufficient and secure resources to permit its prolonged exploitation? - Can tomorrow's nuclear energy be better than today's? This publication provides authoritative and factual replies to these questions. Written primarily to inform policy makers, it will also serve interested members of the public, academics, journalists and industry leaders. (author)

  2. Women in engineering conference: capitalizing on today`s challenges

    Energy Technology Data Exchange (ETDEWEB)

    Metz, S.S.; Martins, S.M. [eds.

    1996-06-01

    This document contains the conference proceedings of the Women in Engineering Conference: Capitalizing on Today`s Challenges, held June 1-4, 1996 in Denver, Colorado. Topics included engineering and science education, career paths, workplace issues, and affirmative action.

  3. Technical report writing today

    CERN Document Server

    Riordan, Daniel G

    2014-01-01

    "Technical Report Writing Today" provides thorough coverage of technical writing basics, techniques, and applications. Through a practical focus with varied examples and exercises, students internalize the skills necessary to produce clear and effective documents and reports. Project worksheets help students organize their thoughts and prepare for assignments, and focus boxes highlight key information and recent developments in technical communication. Extensive individual and collaborative exercises expose students to different kinds of technical writing problems and solutions. Annotated student examples - more than 100 in all - illustrate different writing styles and approaches to problems. Numerous short and long examples throughout the text demonstrate solutions for handling writing assignments in current career situations. The four-color artwork in the chapter on creating visuals keeps pace with contemporary workplace capabilities. The Tenth Edition offers the latest information on using electronic resum...

  4. Knee arthrography today

    International Nuclear Information System (INIS)

    Otto, H.; Kallenberger, R.

    1987-01-01

    The role of knee arthrography today is demonstrated and technical problems are discussed. Among a lot of variants the position of the patient and the choice of contrast media play a great part concerning the result of the examination. Mild complications occur in 0.25% of the examinations, severe and live threatening complications are extremely rare. Diagnosis of meniscal lesions is most important for knee arthrography; arthroscopy and arthrography are complementary examinations and not mutually exclusive, they achieve combined an accuracy of 97-98%. In the same way arthrography is able to evaluate the condropathy of the femoro-tibial joint, whereas accuracy of arthroscopy in the diagnosis of patellar chondropathy is much higher. There is a great reliability of arthrography regarding the evaluation of lesions of the capsule, but accuracy in lesions of the cruciate ligaments is low. Arthrography is very suitable for evaluation of Baker-cysts, since indications for almost occuring internal derangement of the knee are even available. Knee arthrography is a complex and safe procedure with very less discomfort for the patient; it has a central position in the evaluation of lesions of the knee. (orig.) [de

  5. Packaging Printing Today

    Directory of Open Access Journals (Sweden)

    Stanislav Bolanča

    2015-12-01

    Full Text Available Printing packaging covers today about 50% of all the printing products. Among the printing products there are printing on labels, printing on flexible packaging, printing on folding boxes, printing on the boxes of corrugated board, printing on glass packaging, synthetic and metal ones. The mentioned packaging are printed in flexo printing technique, offset printing technique, intaglio halftone process, silk – screen printing, ink ball printing, digital printing and hybrid printing process. The possibilities of particular printing techniques for optimal production of the determined packaging were studied in the paper. The problem was viewed from the technological and economical aspect. The possible printing quality and the time necessary for the printing realization were taken as key parameters. An important segment of the production and the way of life is alocation value and it had also found its place in this paper. The events in the field of packaging printing in the whole world were analyzed. The trends of technique developments and the printing technology for packaging printing in near future were also discussed.

  6. Fiber Sensor Technology Today

    Science.gov (United States)

    Hotate, Kazuo

    2006-08-01

    Fiber sensor technologies are overviewed. Since the early 1970s, this field has been developed, on the basis of the same devices and photonic principles as fiber communication technologies. Besides simple configurations, in which the fiber acts only as a data transmission line, sophisticated configurations have also been developed, in which the fiber is used as a device to realize unique sensing mechanisms. The fiber optic gyroscope (FOG) is a good example, and has been developed as an absolute rotation sensor used, for example, for navigation and/or attitude control applications. Compared with traditional spinning-mass gyroscopes, the FOG has advantages, such as a short warming-up time, a light weight, and easy handling. A Japanese satellite, which was launched in August 2005 with a mission to observe the aurora, is controlled with a FOG. The FOG has also been used in consumer applications, such as the camera stabilizer, radio-controlled (RC) helicopter navigation, and the control of humanoid robots. Recently, distributed and multiplexed sensing schemes, in particular, have been studied and developed, in which a long fiber acts like a “nerve” for feeling the strain and/or the temperature distribution along the fiber. Performances of artificial nerve systems have markedly improved within the last couple of years, in spatial resolution and measurement speed. By embedding the “fiber-optic nerve system” in aircraft wings, bridges and tall buildings, these materials and structures can sense damage to prevent disasters.

  7. Skateboarding injuries of today

    Science.gov (United States)

    Forsman, L; Eriksson, A

    2001-01-01

    Background—Skateboarding injuries have increased with the rise in popularity of the sport, and the injury pattern can be expected to have changed with the development of both skateboard tricks and the materials used for skateboard construction. Objective—To describe the injury pattern of today. Methods—The pattern of injuries, circumstances, and severity were investigated in a study of all 139 people injured in skateboarding accidents during the period 1995–1998 inclusive and admitted to the University Hospital of Umeå. This is the only hospital in the area, serving a population of 135 000. Results—Three of the 139 injured were pedestrians hit by a skateboard rider; the rest were riders. The age range was 7–47 years (mean 16). The severity of the injuries was minor (AIS 1) to moderate (AIS 2); fractures were classified as moderate. The annual number of injuries increased during the study period. Fractures were found in 29% of the casualties, and four children had concussion. The most common fractures were of the ankle and wrist. Older patients had less severe injuries, mainly sprains and soft tissue injuries. Most children were injured while skateboarding on ramps and at arenas; only 12 (9%) were injured while skateboarding on roads. Some 37% of the injuries occurred because of a loss of balance, and 26% because of a failed trick attempt. Falls caused by surface irregularities resulted in the highest proportion of the moderate injuries. Conclusions—Skateboarding should be restricted to supervised skateboard parks, and skateboarders should be required to wear protective gear. These measures would reduce the number of skateboarders injured in motor vehicle collisions, reduce the personal injuries among skateboarders, and reduce the number of pedestrians injured in collisions with skateboarders. Key Words: skateboard; injury; prevention PMID:11579065

  8. Neck collar, "act-as-usual" or active mobilization for whiplash injury? A randomized parallel-group trial

    DEFF Research Database (Denmark)

    Kongsted, Alice; Montvilas, Erisela Qerama; Kasch, Helge

    2007-01-01

    practitioners within 10 days after a whiplash injury and randomized to: 1) immobilization of the cervical spine in a rigid collar followed by active mobilization, 2) advice to "act-as-usual," or 3) an active mobilization program (Mechanical Diagnosis and Therapy). Follow-up was carried out after 3, 6, and 12......-extension trauma to the cervical spine. It is unclear whether this, in some cases disabling, condition can be prevented by early intervention. Active interventions have been recommended but have not been compared with information only. Methods. Participants were recruited from emergency units and general......Study Design. Randomized, parallel-group trial. Objective. To compare the effect of 3 early intervention strategies following whiplash injury. Summary of Background Data. Long-lasting pain and disability, known as chronic whiplash-associated disorder (WAD), may develop after a forced flexion...

  9. Neck collar, "act-as-usual" or active mobilization for whiplash injury? A randomized parallel-group trial

    DEFF Research Database (Denmark)

    Kongsted, Alice; Montvilas, Erisela Qerama; Kasch, Helge

    2007-01-01

    Study Design. Randomized, parallel-group trial. Objective. To compare the effect of 3 early intervention strategies following whiplash injury. Summary of Background Data. Long-lasting pain and disability, known as chronic whiplash-associated disorder (WAD), may develop after a forced flexion......-extension trauma to the cervical spine. It is unclear whether this, in some cases disabling, condition can be prevented by early intervention. Active interventions have been recommended but have not been compared with information only. Methods. Participants were recruited from emergency units and general...... practitioners within 10 days after a whiplash injury and randomized to: 1) immobilization of the cervical spine in a rigid collar followed by active mobilization, 2) advice to "act-as-usual," or 3) an active mobilization program (Mechanical Diagnosis and Therapy). Follow-up was carried out after 3, 6, and 12...

  10. Information services today an introduction

    CERN Document Server

    Hirsh, Sandra

    2015-01-01

    This essential overview of what it means to be a library and information professional today provides a broad overview of the transformation of libraries as information organizations, why these organizations are more important today than ever before, the technological influence on how we provide information resources and services in today's digital and global environment, and the various career opportunities available for information professionals. The book begins with a historical overview of libraries and their transformation as information and technology

  11. A trial of e-simulation of sudden patient deterioration (FIRST2ACT WEB) on student learning.

    Science.gov (United States)

    Bogossian, Fiona E; Cooper, Simon J; Cant, Robyn; Porter, Joanne; Forbes, Helen

    2015-10-01

    High-fidelity simulation pedagogy is of increasing importance in health professional education; however, face-to-face simulation programs are resource intensive and impractical to implement across large numbers of students. To investigate undergraduate nursing students' theoretical and applied learning in response to the e-simulation program-FIRST2ACT WEBTM, and explore predictors of virtual clinical performance. Multi-center trial of FIRST2ACT WEBTM accessible to students in five Australian universities and colleges, across 8 campuses. A population of 489 final-year nursing students in programs of study leading to license to practice. Participants proceeded through three phases: (i) pre-simulation-briefing and assessment of clinical knowledge and experience; (ii) e-simulation-three interactive e-simulation clinical scenarios which included video recordings of patients with deteriorating conditions, interactive clinical tasks, pop up responses to tasks, and timed performance; and (iii) post-simulation feedback and evaluation. Descriptive statistics were followed by bivariate analysis to detect any associations, which were further tested using standard regression analysis. Of 409 students who commenced the program (83% response rate), 367 undergraduate nursing students completed the web-based program in its entirety, yielding a completion rate of 89.7%; 38.1% of students achieved passing clinical performance across three scenarios, and the proportion achieving passing clinical knowledge increased from 78.15% pre-simulation to 91.6% post-simulation. Knowledge was the main independent predictor of clinical performance in responding to a virtual deteriorating patient R(2)=0.090, F(7, 352)=4.962, plearning. The web-based e-simulation program FIRST2ACTTM effectively enhanced knowledge, virtual clinical performance, and self-assessed knowledge, skills, confidence, and competence in final-year nursing students. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Construction Management Meets Today's Realities.

    Science.gov (United States)

    Day, C. William

    1979-01-01

    Construction management--the control of cost and time from concept through construction--grew out of a need to meet the realities of today's economy. A checklist of services a construction manager provides is presented. (Author/MLF)

  13. "UK today" Tallinnas / Tuuli Oder

    Index Scriptorium Estoniae

    Oder, Tuuli, 1958-

    2001-01-01

    Vabariikliku inglise keele olümpiaadi raames toimus Tallinnas viktoriini "UK today" lõppvoor. Osalesid 22 kooli kaheliikmelised võistkonnad. Viktoriini tulemused koolide lõikes ja küsimused õigete vastustega

  14. Partnerships for technology introduction -- Putting the technologies of tomorrow into the marketplace of today. Report to Congress on Sections 127 and 128 of the Energy Policy Act of 1992

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This report to Congress was prepared on behalf of the Secretary of the US Department of Energy (DOE) in response to Sections 127 and 128 of the Energy Policy Act of 1992 (EPAct), Pub. L. 102-486. In preparing the report to the Congress, DOE has assessed the national and regional energy savings potential of products already on the market and those that will be available to consumers by the late 1990s. The Department has also examined the present cost-effectiveness of these emerging appliances as mature technologies. To help in its assessment, DOE organized eight workshops at which representatives from manufacturing and building industries, utilities, retailers and wholesalers, public interest groups and Federal and state government agencies could express their views. The information derived from these workshops was key to the formulation of the report`s general and specific recommendations. DOE has concluded that the Federal Government can effectively stimulate the market for emerging technologies by forming partnerships with the appliance industry and other interested parties promoting the use of highly efficient appliances. Based on the interaction with industry at the eight workshops and through direct contact, DOE has concluded that Federal action and technical assistance is not only desired by industry, but crucial to the expansion of these markets. Section 128 of EPAct requires an assessment of the energy savings and environmental benefits of replacing older, less efficient appliances with more efficient products than currently required by Federal law. Since early replacement of appliances is but one possible market-stimulating action, DOE has elected to include its discussion as part of the overall report to the Congress.

  15. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... today. ANNUAL FUND Become a Corporate Supporter Cause Marketing Make a Charitable Gift Our Corporate Supporters Workplace ... Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your airways. Most are easy to ...

  16. Nuclear technology today and tomorrow

    International Nuclear Information System (INIS)

    Lombardi, C.

    2007-01-01

    Nuclear power has returned today to contain the energy problem. It is useful to make a summary of its characteristics and its evolution over the past 50 years and its prospects. The Italy can rely on their way by revitalizing its potential not fully disappeared [it

  17. School Counseling in China Today

    Science.gov (United States)

    Thomason, Timothy C.; Qiong, Xiao

    2008-01-01

    This article provides a brief overview of the development of psychological thinking in China and social influences on the practice of school counseling today. Common problems of students are described, including anxiety due to pressure to perform well on exams, loneliness and social discomfort, and video game addiction. Counseling approaches used…

  18. A new reversible and potent P2Y12 receptor antagonist (ACT-246475): tolerability, pharmacokinetics, and pharmacodynamics in a first-in-man trial.

    Science.gov (United States)

    Baldoni, Daniela; Bruderer, Shirin; Krause, Andreas; Gutierrez, Marcello; Gueret, Pierre; Astruc, Béatrice; Dingemanse, Jasper

    2014-11-01

    ACT-246475 is a new reversible, selective, and potent antagonist of the platelet P2Y12 receptor. This study was a first-in-man trial investigating the tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of ACT-246475 and its di-ester prodrug (ACT-281959) in healthy males. The study had a double-blind, randomized, ascending single-dose design with an oral formulation F1 (i.e., ACT-281959 or placebo) (Part I) and an open-label, randomized, 3-period, crossover design comparing exploratory formulations of ACT-281959 (F2) 70 mg and ACT-246475 (dF) 50 mg to F1 70 mg (Part II). In Part I, doses up to 1,000 mg were tested in 40 healthy subjects. Nine healthy subjects were enrolled in Part II. Standard safety parameters, inhibition of platelet aggregation, and ACT-246475 plasma concentrations were measured. Non-compartmental pharmacokinetic analysis was performed. All doses and formulations were well tolerated. The most frequent adverse event was headache, whereas no events of bleeding or dyspnea were reported. In Part I, ACT-246475 area under the plasma concentration-time curve (AUC) increased dose-proportionally whereas maximum plasma concentration (C max) was less than dose-proportional. The highest C max [geometric mean (95 % CI)] at 1,000 mg was 13.8 (9.7, 19.5) pmol/mL at 4.5 h post-dose, terminal half-life (t ½) was ~10 h. ACT-246475 C max and AUC0-∞ ratios of geometric means (90 % CI) using F1 as reference, for F2 were 8.5 (5.42, 13.35) and 3.4 (2.40, 4.82), respectively, and for dF 2.2 (1.42, 3.49) and 1.5 (1.07, 2.16), respectively. Mean peak platelet inhibition was 31.0 % after F1 (1,000 mg) and 47.8 % after F2. Oral doses of ACT-281959 and ACT-246475 were well tolerated. Platelet inhibition correlated with ACT-246475 exposure. Exploratory formulations enhanced the bioavailability and antiplatelet effect of ACT-246475.

  19. Exercise combined with Acceptance and Commitment Therapy (ExACT) compared to a supervised exercise programme for adults with chronic pain: study protocol for a randomised controlled trial.

    Science.gov (United States)

    Casey, Máire-Bríd; Smart, Keith; Segurado, Ricardo; Hearty, Conor; Gopal, Hari; Lowry, Damien; Flanagan, Dearbhail; McCracken, Lance; Doody, Catherine

    2018-03-22

    Acceptance and Commitment Therapy (ACT) is a form of cognitive behavioural therapy, which may be beneficial for people with chronic pain. The approach aims to enhance daily functioning through increased psychological flexibility. Whilst the therapeutic model behind ACT appears well suited to chronic pain, there is a need for further research to test its effectiveness in clinical practice, particularly with regards to combining ACT with physical exercise. This prospective, two-armed, parallel-group, single-centre randomised controlled trial (RCT) will assess the effectiveness of a combined Exercise and ACT programme, in comparison to supervised exercise for chronic pain. One hundred and sixty patients, aged 18 years and over, who have been diagnosed with a chronic pain condition by a physician will be recruited to the trial. Participants will be individually randomised to one of two 8-week, group interventions. The combined group will take part in weekly psychology sessions based on the ACT approach, in addition to supervised exercise classes led by a physiotherapist. The control group will attend weekly supervised exercise classes but will not take part in an ACT programme. The primary outcome will be pain interference at 12-week follow-up, measured using the Brief Pain Inventory-Interference Scale. Secondary outcomes will include self-reported pain severity, self-perception of change, patient satisfaction, quality of life, depression, anxiety and healthcare utilisation. Treatment process measures will include self-efficacy, pain catastrophising, fear avoidance, pain acceptance and committed action. Physical activity will be measured using Fitbit Zip TM activity trackers. Both groups will be followed up post intervention and again after 12 weeks. Estimates of treatment effects at follow-up will be based on an intention-to-treat framework, implemented using a linear mixed-effects model. Individual and focus group qualitative interviews will be undertaken with a

  20. Clinical Trials

    Medline Plus

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  1. Clinical Trials

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    Full Text Available ... medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are a key research tool for ... and Usage No FEAR Act Grants and Funding Customer Service/Center for Health Information Email Alerts Jobs ...

  2. Strategic planning: today's hot buttons.

    Science.gov (United States)

    Bohlmann, R C

    1998-01-01

    The first generation of mergers and managed care hasn't slowed down group practices' need for strategic planning. Even groups that already went through one merger are asking about new mergers or ownership possibilities, the future of managed care, performance standards and physician unhappiness. Strategic planning, including consideration of bench-marking, production of ancillary services and physician involvement, can help. Even if only a short, general look at the future, strategic planning shows the proactive leadership needed in today's environment.

  3. Long acting β2 agonists for stable chronic obstructive pulmonary disease with poor reversibility: a systematic review of randomised controlled trials

    Directory of Open Access Journals (Sweden)

    Mensinkai Shaila

    2004-08-01

    Full Text Available Abstract Background The long acting β2-agonists, salmeterol and formoterol, have been recommended, by some, as first line treatment of stable chronic obstructive pulmonary disease (COPD. We reviewed evidence of efficacy and safety when compared with placebo or anticholinergic agents in patients with poorly reversible COPD. Methods After searching MEDLINE, EMBASE, HealthSTAR, BIOSIS Previews, PASCAL, ToxFile, SciSearch, the Cochrane Library, and PubMed, as well as Web sites, selected journals, reference lists, and contacting drug manufacturers, two reviewers independently screened reports of randomised controlled trials of parallel or crossover design lasting four weeks or longer and including patients with a forced expiratory volume in one second (FEV1 ≤ 75% of predicted, a ratio of FEV1 to forced vital capacity (FVC ≤ 88% of predicted, and Results Twelve trials satisfied our inclusion criteria; eight were high quality (Jadad score >2 and four were low quality (≤ 2. The adequacy of allocation concealment was unclear in all of them. We did not perform a meta-analysis due to differences in trial design and how outcomes were reported. Two trials comparing salmeterol with ipratropium did not detect differences; one trial comparing formoterol and ipratropium described greater improvement with formoterol in morning PEFR (15.3 versus 7.1 l/min, p = 0.040. Of twelve trials comparing long acting β2 agonists with placebo, six reported no improvement in exercise capacity, eleven reported improvements in FEV1 lung function (one reported no improvement, six reported less rescue inhaler usage (one reported no difference and five reported improved dyspnea scores (two reported no improvement. Differences in quality of life were detected in one salmeterol trial ; however, two salmeterol, and one formoterol trial reported no differences. Adverse effects of interest were not reported. Conclusion In terms of clinical outcomes and safety, we could not find

  4. Web publishing today and tomorrow

    CERN Document Server

    Lie, Hakon W

    1999-01-01

    The three lectures will give participants the grand tour of the Web as we know it today, as well as peeks into the past and the future. Many three-letter acronyms will be expanded, and an overview will be provided to see how the various specifications work together. Web publishing is the common theme throughout the lectures and in the second lecture, special emphasis will be given to data formats for publishing, including HTML, XML, MathML and SMIL. In the last lectures, automatic document manipulation and presentation will be discussed, including CSS, DOM and XTL.

  5. Cognitive-behavioral therapy (CBT) versus acceptance and commitment therapy (ACT) for dementia family caregivers with significant depressive symptoms: Results of a randomized clinical trial.

    Science.gov (United States)

    Losada, Andrés; Márquez-González, María; Romero-Moreno, Rosa; Mausbach, Brent T; López, Javier; Fernández-Fernández, Virginia; Nogales-González, Celia

    2015-08-01

    The differential efficacy of acceptance and commitment therapy (ACT) and cognitive-behavioral therapy (CBT) for dementia family caregivers' is analyzed through a randomized controlled trial. Participants were 135 caregivers with high depressive symptomatology who were randomly allocated to the intervention conditions or a control group (CG). Pre-, postintervention, and follow-up measurements assessed depressive symptomatology, anxiety, leisure, dysfunctional thoughts, and experiential avoidance. Depression: Significant effects of interventions compared with CG were found for CBT (p dementia caregivers. (c) 2015 APA, all rights reserved).

  6. The sexual history provisions in the Youth Justice and Criminal Evidence Act 1999--a violation of the right to a fair trial?

    Science.gov (United States)

    Young, G

    2001-07-01

    In response to the Home Office recommendations contained in Speaking Up for Justice (1998) the Youth Justice and Criminal Evidence Act (YJCEA) 1999 introduced a new regime for the conduct of sexual offence trials. Section 41 of the Act, which came into force on 4 December 2000, brings about dramatic changes to the rules on the admissibility of evidence of complainants' sexual behaviour, severely restricting the discretion of trial judges to introduce such evidence or to allow questioning concerning it. This represents a radical new departure that will fundamentally affect an accused's position at trial. Responses to section 41 have predictably been divided given the extremely sensitive nature of this area of the law of evidence and the complex set of social and political issues which are at stake. Many have greeted it as a long overdue reform of a system premised upon outmoded and sexist beliefs concerning women's sexual behaviour which has routinely functioned to admit prejudicial and irrelevant evidence. Others, predominantly within the legal profession, have expressed serious concerns over whether the new law is workable and the extent to which, by potentially excluding critically relevant evidence, it may infringe upon a defendant's right to a fair trial. The quality of the legislation is soon to be tested. On 26 and 27 March 2001 the House of Lords heard an interlocutory appeal in the case of R v. A and were asked to decide if the new provisions, by excluding previous sexual history evidence between the complainant and the defendant, contravened Article 6 of the European Convention of Human Rights. Their Lordships are, at the time of writing, yet to give judgment and the fate of the defendant in question, and several others whose trials have been postponed pending their decision, hangs in the balance. This article seeks to show that the new Act, despite being well-intentioned, does not adopt a coherent or sustainable approach to the relevance of previous

  7. Pregnancy outcomes in youth with type 2 diabetes: The TODAY Study experience

    Science.gov (United States)

    We evaluated pregnancy outcomes, maternal and fetal/neonatal, during the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study. The TODAY study was a randomized controlled trial comparing three treatment options for youth with type 2 diabetes. Informed consent included the req...

  8. Improving urban African Americans' blood pressure control through multi-level interventions in the Achieving Blood Pressure Control Together (ACT) study: a randomized clinical trial.

    Science.gov (United States)

    Ephraim, Patti L; Hill-Briggs, Felicia; Roter, Debra L; Bone, Lee R; Wolff, Jennifer L; Lewis-Boyer, LaPricia; Levine, David M; Aboumatar, Hanan J; Cooper, Lisa A; Fitzpatrick, Stephanie J; Gudzune, Kimberly A; Albert, Michael C; Monroe, Dwyan; Simmons, Michelle; Hickman, Debra; Purnell, Leon; Fisher, Annette; Matens, Richard; Noronha, Gary J; Fagan, Peter J; Ramamurthi, Hema C; Ameling, Jessica M; Charlston, Jeanne; Sam, Tanyka S; Carson, Kathryn A; Wang, Nae-Yuh; Crews, Deidra C; Greer, Raquel C; Sneed, Valerie; Flynn, Sarah J; DePasquale, Nicole; Boulware, L Ebony

    2014-07-01

    Given their high rates of uncontrolled blood pressure, urban African Americans comprise a particularly vulnerable subgroup of persons with hypertension. Substantial evidence has demonstrated the important role of family and community support in improving patients' management of a variety of chronic illnesses. However, studies of multi-level interventions designed specifically to improve urban African American patients' blood pressure self-management by simultaneously leveraging patient, family, and community strengths are lacking. We report the protocol of the Achieving Blood Pressure Control Together (ACT) study, a randomized controlled trial designed to study the effectiveness of interventions that engage patient, family, and community-level resources to facilitate urban African American hypertensive patients' improved hypertension self-management and subsequent hypertension control. African American patients with uncontrolled hypertension receiving health care in an urban primary care clinic will be randomly assigned to receive 1) an educational intervention led by a community health worker alone, 2) the community health worker intervention plus a patient and family communication activation intervention, or 3) the community health worker intervention plus a problem-solving intervention. All participants enrolled in the study will receive and be trained to use a digital home blood pressure machine. The primary outcome of the randomized controlled trial will be patients' blood pressure control at 12months. Results from the ACT study will provide needed evidence on the effectiveness of comprehensive multi-level interventions to improve urban African American patients' hypertension control. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Randomized Clinical Trial of Cognitive Behavioral Therapy (CBT) versus Acceptance and Commitment Therapy (ACT) for Mixed Anxiety Disorders

    Science.gov (United States)

    Arch, Joanna J.; Eifert, Georg H.; Davies, Carolyn; Vilardaga, Jennifer C. Plumb; Rose, Raphael D.; Craske, Michelle G.

    2012-01-01

    Objective: Randomized comparisons of acceptance-based treatments with traditional cognitive behavioral therapy (CBT) for anxiety disorders are lacking. To address this gap, we compared acceptance and commitment therapy (ACT) to CBT for heterogeneous anxiety disorders. Method: One hundred twenty-eight individuals (52% female, mean age = 38, 33%…

  10. Today's threat and tomorrow's reaction

    International Nuclear Information System (INIS)

    Moore, L.R.

    2002-01-01

    Full text: The events of September 11 have only confirmed our past nightmares and warnings to industries, agencies, and governments. The threat of even more significant catastrophic attacks, using nuclear materials, was just as real ten years ago, as it is today. In many cases, our vulnerability remains the same as years ago. There is a dire need for all organizations to agree upon threats and vulnerabilities, and to implement appropriate protections, for nuclear materials or other 'means' to achieve an event of mass destruction. All appropriate organizations (industries, agencies, and governments) should be able to define, assess, and recognize international threats and vulnerabilities in the same manner. In complimentary fashion, the organizations should be able to implement safeguards against this consistent generic threat. On an international scale the same threats, and most vulnerabilities, pose high risks to all of these organizations and societies. Indeed, in today's world, the vulnerabilities of one nation may clearly pose great risk to another nation. Once threats and vulnerabilities are consistently recognized, we can begin to approach their mitigation in a more 'universal' fashion by the application of internationally recognized and accepted security measures. The path to recognition of these security measures will require agreement on many diverse issues. However, once there is general agreement, we can then proceed to the acquisition of diverse national and international resources with which to implement the security measures 'universally' to eliminate 'weak-links' in the chain of nuclear materials, on a truly international scale. I would like to discuss: developing a internationally acceptable 'generic' statement of threat, vulnerability assessment process, and security measure; proposing this international statement of threat, vulnerability assessment process, and appropriate security measures to organizations (industries, agencies, and governments

  11. Religious Renaissance in China Today

    Directory of Open Access Journals (Sweden)

    Richard Madsen

    2011-01-01

    Full Text Available Since the beginning of the Reform Era in 1979, there has been a rapid growth and development of religious belief and practice in China. A substantial new scholarly literature has been generated in the attempt to document and understand this. This essay identifies the most important contributions to that literature and discusses areas of agreement and controversy across the literature. Along with new data, new paradigms have developed to frame research on Chinese religions. The paradigm derived from C. K. Yang’s classic work in the 1960s came from structural functionalism, which served to unite research in the humanities and social sciences. However, structural functionalism has been abandoned by the new generation of scholars. In the humanities, the most popular paradigm derives from Michel Foucault, but there are also scholars who use neo-Durkheimian and neo-Weberian paradigms. In the social sciences, the dominant paradigms tend to focus on state-society relations. None of these paradigms fully captures the complexity of the transformations happening in China. We recommend greater dialogue between the humanities and social sciences in search of more adequate theoretical frameworks for understanding Chinese religions today.

  12. The Coolness of Capitalism Today

    Directory of Open Access Journals (Sweden)

    Jim McGuigan

    2012-05-01

    Full Text Available This paper is about the reconciliation of cultural analysis with political economy in Marxist-inspired research on communications. It traces how these two traditions became separated with the development of a one-dimensional and consumerist cultural studies, on the one-hand, and a more classically Marxist political economy of communications, on the other hand, that was accused of holding a simplistic and erroneous concept of ideology. The paper defends a conception of ideology as distorted communication motivated by unequal power relations and sketches a multidimensional mode of cultural analysis that takes account of the moments of production, consumption and textual meaning in the circulation of communications and culture. In accordance with this framework of analysis, the cool-capitalism thesis is outlined and illustrated with reference to Apple, the ‘cool’ corporation. And, the all-purpose mobile communication device is selected as a key and urgent focus of attention for research on commodity fetishism and labour exploitation on a global scale today.

  13. Tritium. Today's and tomorrow's developments

    International Nuclear Information System (INIS)

    Gazal, S.; Amiard, J.C.; Caussade, Bernard; Chenal, Christian; Hubert, Francoise; Sene, Monique

    2010-01-01

    Radioactive hydrogen isotope, tritium is one of the radionuclides which is the most released in the environment during the normal operation of nuclear facilities. The increase of nuclear activities and the development of future generations of reactors, like the EPR and ITER, would lead to a significant increase of tritium effluents in the atmosphere and in the natural waters, thus raising many worries and questions. Aware about the importance of this question, the national association of local information commissions (ANCLI) wished to make a status of the existing knowledge concerning tritium and organized in 2008 a colloquium at Orsay (France) with an inquiring approach. The scientific committee of the ANCLI, renowned for its expertise skills, mobilized several nuclear specialists to carry out this thought. This book represents a comprehensive synthesis of today's knowledge about tritium, about its management and about its impact on the environment and on human health. Based on recent scientific data and on precise examples, it treats of the overall questions raised by this radionuclide: 1 - tritium properties and different sources (natural and anthropic), 2 - the problem of tritiated wastes management; 3 - the bio-availability and bio-kinetics of the different tritium species; 4 - the tritium labelling of environments; 5 - tritium measurement and modeling of its environmental circulation; 6 - tritium radio-toxicity and its biological and health impacts; 7 - the different French and/or international regulations concerning tritium. (J.S.)

  14. Gas market is today strategical

    International Nuclear Information System (INIS)

    Darricarrere, Y.L.

    2006-01-01

    The energy market, and in particular the gas market, is today seething with excitement. In France, in Europe and in the rest of the world, the energy stakes are in the center of preoccupations. This article is an interview of Y.L. Darricarrere, general director of the gas and electricity division of Total group, who explains his opinions about the opening of European and French energy markets, presents the ambitions of Total group on these markets, and comments some recent events of the European energy scene: concentration between gas and electric utilities, the Suez and Gaz de France (GdF) project of merger, the risks linked with the coming in of national companies from producing countries, like Gazprom and Sonatrach, on the European market, the restriction of access of foreign companies to hydrocarbon reserves in Russia and Latin America (come back of the 'energy nationalism'), Total's policy for anticipating the increase of the world energy demand and the depletion of fossil fuel reserves. (J.S.)

  15. Artificial insemination in pigs today.

    Science.gov (United States)

    Knox, R V

    2016-01-01

    Use of artificial insemination (AI) for breeding pigs has been instrumental for facilitating global improvements in fertility, genetics, labor, and herd health. The establishment of AI centers for management of boars and production of semen has allowed for selection of boars for fertility and sperm production using in vitro and in vivo measures. Today, boars can be managed for production of 20 to 40 traditional AI doses containing 2.5 to 3.0 billion motile sperm in 75 to 100 mL of extender or 40 to 60 doses with 1.5 to 2.0 billion sperm in similar or reduced volumes for use in cervical or intrauterine AI. Regardless of the sperm dose, in liquid form, extenders are designed to sustain sperm fertility for 3 to 7 days. On farm, AI is the predominant form for commercial sow breeding and relies on manual detection of estrus with sows receiving two cervical or two intrauterine inseminations of the traditional or low sperm doses on each day detected in standing estrus. New approaches for increasing rates of genetic improvement through use of AI are aimed at methods to continue to lower the number of sperm in an AI dose and reducing the number of inseminations through use of a single, fixed-time AI after ovulation induction. Both approaches allow greater selection pressure for economically important swine traits in the sires and help extend the genetic advantages through AI on to more production farms. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. A study protocol for a randomised open-label clinical trial of artesunate-mefloquine versus chloroquine in patients with non-severe Plasmodium knowlesi malaria in Sabah, Malaysia (ACT KNOW trial)

    Science.gov (United States)

    Grigg, M J; William, T; Dhanaraj, P; Menon, J; Barber, B E; von Seidlein, L; Rajahram, G; Price, R N; Anstey, N M; Yeo, T W

    2014-01-01

    Introduction Malaria due to Plasmodium knowlesi is reported throughout South-East Asia, and is the commonest cause of it in Malaysia. P. knowlesi replicates every 24 h and can cause severe disease and death. Current 2010 WHO Malaria Treatment Guidelines have no recommendations for the optimal treatment of non-severe knowlesi malaria. Artemisinin-combination therapies (ACT) and chloroquine have each been successfully used to treat knowlesi malaria; however, the rapidity of parasite clearance has not been prospectively compared. Malaysia's national policy for malaria pre-elimination involves mandatory hospital admission for confirmed malaria cases with discharge only after two negative blood films; use of a more rapidly acting antimalarial agent would have health cost benefits. P. knowlesi is commonly microscopically misreported as P. malariae, P. falciparum or P. vivax, with a high proportion of the latter two species being chloroquine-resistant in Malaysia. A unified ACT-treatment protocol would provide effective blood stage malaria treatment for all Plasmodium species. Methods and analysis ACT KNOW, the first randomised controlled trial ever performed in knowlesi malaria, is a two-arm open-label trial with enrolments over a 2-year period at three district sites in Sabah, powered to show a difference in proportion of patients negative for malaria by microscopy at 24 h between treatment arms (clinicaltrials.gov #NCT01708876). Enrolments started in December 2012, with completion expected by September 2014. A total sample size of 228 is required to give 90% power (α 0.05) to determine the primary end point using intention-to-treat analysis. Secondary end points include parasite clearance time, rates of recurrent infection/treatment failure to day 42, gametocyte carriage throughout follow-up and rates of anaemia at day 28, as determined by survival analysis. Ethics and dissemination This study has been approved by relevant institutional ethics committees in

  17. A first-in-man phase 1 trial for long-acting TransCon Growth Hormone.

    Science.gov (United States)

    Gilfoyle, David; Mortensen, Eva; Christoffersen, Eva Dam; Leff, Jonathan A; Beckert, Michael

    2018-04-01

    TransCon growth hormone (GH) is a sustained-release inactive prodrug consisting of unmodified GH transiently bound to an inert carrier molecule designed to release fully active GH over a one-week period. This was a first-in-man phase 1 randomized trial was to evaluate the safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) of a single dose of TransCon GH as compared to equivalent doses of daily GH (Omnitrope) or placebo in healthy adults. Forty-four healthy male adults were randomized to 4 cohorts of 11 subjects, distributed in a 7:2:2 ratio (TransCon GH: Omnitrope: placebo). A single injection of 4 possible TransCon GH doses (i.e., 0.04, 0.08, 0.16, or 0.24mg GH/kg/wk) or two different Omnitrope doses (i.e., 0.08 or 0.16mg GH/kg/wk divided into 7 equal daily doses) were administered with subjects evaluated for adverse events, immunogenicity, and GH and insulin-like growth factor-1 (IGF-1) levels. TransCon GH was well tolerated; no serious adverse events occurred, no injection site reaction differences between TransCon GH, Omnitrope, or placebo were identified, no nodules or lipoatrophy were reported, and no anti-GH binding antibodies or ECG changes were detected. Overall, the exposure of GH (C max ) and IGF-1 (AUC 0-168h ) following administration of equivalent doses of TransCon GH and Omnitrope were similar. GH and IGF-1 kinetics showed a dose-proportional increase following a single SC administration of TransCon GH and indicated that the prodrug is suitable for weekly administration. These results support advancement of TransCon GH to pediatric and adult GHD trials. Clinical trial registration numbers: NCT01010425 (clinicaltrials.gov). Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. The Status of Hitler Today

    Directory of Open Access Journals (Sweden)

    Ben Novak

    2009-12-01

    Full Text Available A finales del siglo XX, podía afirmarse que Hitler estaba más vivo y con más influencia que en la cumbre de su poder medio siglo antes. ¿Cómo ha alcanzado Hitler esta posición? ¿No está muerto? ¿Cómo puede ser tan prominente más de cincuenta años después de su defunción? Esta cuestión de Hitler en la actualidad posee diversos problemas históricos que están íntimamente conectados con otros morales. En este trabajo, sin embargo, pretendo concentrarme primordialmente en su dimensión histórica. A la luz del sorprendente ascenso de Hitler en la moderna conciencia histórica, esto puede llevarnos a la siguiente pregunta: ¿No hemos otorgado al dictador nazi un poder aún mayor que cuando estaba vivo y comandando sus divisiones de la Wehrmacht en el punto culminante de sus conquistas?___________________ABSTRACT:By the end of the twentieth century, it can be said, Hitler was more alive and prominent than at the height of his power a half-century before. How did Hitler become this way? Isn’t he dead? How can he become so prominent more than half a century after his death? The issue of Hitler today poses several historical problems that are deeply moral problems as well. In this work, however, I intend to concentrate primarily on their historical dimension. In light of Hitler’s astonishing rise in modern historical consciousness, this leads to the inevitable question: Have we not granted to Hitler a far greater power over us than ever he had when he was alive and commanding his Wehrmacht divisions at the farthest extent of his conquests?

  19. Trials

    Directory of Open Access Journals (Sweden)

    Michele Fornaro

    2010-01-01

    Full Text Available Mental Retardation (MR is a developmental disability characterized by impairments in adaptive daily life skills and difficulties in social and interpersonal functioning. Since multiple causes may contribute to MR, associated clinical pictures may vary accordingly. Nevertheless, when psychiatric disorders as Treatment Resistant Depression (TRD and/or alcohol abuse co-exist, their proper detection and management is often troublesome, essentially due to a limited vocabulary MR people could use to describe their symptoms, feelings and concerns, and the lack of reliable screening tools. Furthermore, MR people are among the most medicated subjects, with (over prescription of antidepressants and/or typical antipsychotics being the rule rather than exception. Thus, treatment resistance or even worsening of depression, constitute frequent occurrences. This report describes the case of a person with MR who failed to respond to repetitive trials of antidepressant monotherapies, finally recovering using aripiprazole to fluvoxamine augmentation upon consideration of a putative bipolar diathesis for “agitated” TRD. Although further controlled investigations are needed to assess a putative bipolar diathesis in some cases of MR associated to TRD, prudence is advised in the long-term prescription of antidepressant monotherapies in such conditions.

  20. Prospective trial of customized adherence enhancement plus long-acting injectable antipsychotic medication in homeless or recently homeless individuals with schizophrenia or schizoaffective disorder.

    Science.gov (United States)

    Sajatovic, Martha; Levin, Jennifer; Ramirez, Luis F; Hahn, David Y; Tatsuoka, Curtis; Bialko, Christopher S; Cassidy, Kristin A; Fuentes-Casiano, Edna; Williams, Tiffany D

    2013-12-01

    Treatment nonadherence in people with schizophrenia is associated with relapse and homelessness. Building on the usefulness of long-acting medication and our work in psychosocial interventions to enhance adherence, we conducted a prospective uncontrolled trial of customized adherence enhancement (CAE) plus long-acting injectable antipsychotic (LAI) using haloperidol decanoate in 30 homeless or recently homeless individuals with DSM-IV-defined schizophrenia or schizoaffective disorder. Participants received monthly CAE and LAI (CAE-L) for 6 months. Primary outcomes were adherence, as measured by the Tablets Routine Questionnaire, and housing status. Secondary outcomes included psychiatric symptoms, functioning, side effects, and hospitalizations. The study was conducted from July 2010 to December 2012. The mean age of participants was 41.8 years (SD = 8.6); they were mainly minorities (90%, n = 27 African-American) and mainly single/never married (70%, n = 21). Most (97%, n = 29) had past or current substance abuse and had been incarcerated (97%, n = 29). Ten individuals (33%) terminated the study prematurely. CAE-L was associated with good adherence to LAI (at 6 months, 76%) and dramatic improvement in oral medication adherence, which changed from missing 46% of medication at study enrollment to missing only 10% at study end (P = .03). There were significant improvements in psychiatric symptoms (P effect with LAI. While interpretation of findings must be tempered by the methodological limitations, CAE-L appears to be associated with improved adherence, symptoms, and functioning in homeless or recently homeless individuals with schizophrenia or schizoaffective disorder. Additional research is needed on effective and practical approaches to improving health outcomes for homeless people with serious mental illness. ClinicalTrials.gov identifier: NCT01152697. © Copyright 2013 Physicians Postgraduate Press, Inc.

  1. Long-acting insulin analogues for type 1 diabetes: An overview of systematic reviews and meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Laranjeira, Fernanda O; de Andrade, Keitty R C; Figueiredo, Ana C M G; Silva, Everton N; Pereira, Mauricio G

    2018-01-01

    The comparison between long acting insulin analogues (LAIA) and human insulin (NPH) has been investigated for decades, with many randomized controlled trials (RCTs) and systematic reviews giving mixed results. This overlapping and contradictory evidence has increased uncertainty on coverage decisions at health systems level. To conduct an overview of systematic reviews and update existing reviews, preparing new meta-analysis to determine whether LAIA are effective for T1D patients compared to NPH. We identified systematic reviews of RCTs that evaluated the efficacy of LAIA glargine or detemir, compared to NPH insulin for T1D, assessing glycated hemoglobin (A1C) and hypoglycemia. Data sources included Pubmed, Cochrane Library, EMBASE and hand-searching. The methodological quality of studies was independently assessed by two reviewers, using AMSTAR and Jadad scale. We found 11 eligible systematic reviews that contained a total of 25 relevant clinical trials. Two reviewers independently abstracted data. We found evidence that LAIA are efficacious compared to NPH, with estimates showing a reduction in nocturnal hypoglycemia episodes (RR 0.66; 95% CI 0.57; 0.76) and A1C (95% CI 0.23; 0.12). No significance was found related to severe hypoglycemia (RR 0.94; 95% CI 0.71; 1.24). This study design has allowed us to carry out the most comprehensive assessment of RCTs on this subject, filling a gap in diabetes research. Our paper addresses a question that is important not only for decision makers but also for clinicians.

  2. A study protocol for a randomised open-label clinical trial of artesunate-mefloquine versus chloroquine in patients with non-severe Plasmodium knowlesi malaria in Sabah, Malaysia (ACT KNOW trial).

    Science.gov (United States)

    Grigg, M J; William, T; Dhanaraj, P; Menon, J; Barber, B E; von Seidlein, L; Rajahram, G; Price, R N; Anstey, N M; Yeo, T W

    2014-08-19

    Malaria due to Plasmodium knowlesi is reported throughout South-East Asia, and is the commonest cause of it in Malaysia. P. knowlesi replicates every 24 h and can cause severe disease and death. Current 2010 WHO Malaria Treatment Guidelines have no recommendations for the optimal treatment of non-severe knowlesi malaria. Artemisinin-combination therapies (ACT) and chloroquine have each been successfully used to treat knowlesi malaria; however, the rapidity of parasite clearance has not been prospectively compared. Malaysia's national policy for malaria pre-elimination involves mandatory hospital admission for confirmed malaria cases with discharge only after two negative blood films; use of a more rapidly acting antimalarial agent would have health cost benefits. P. knowlesi is commonly microscopically misreported as P. malariae, P. falciparum or P. vivax, with a high proportion of the latter two species being chloroquine-resistant in Malaysia. A unified ACT-treatment protocol would provide effective blood stage malaria treatment for all Plasmodium species. ACT KNOW, the first randomised controlled trial ever performed in knowlesi malaria, is a two-arm open-label trial with enrolments over a 2-year period at three district sites in Sabah, powered to show a difference in proportion of patients negative for malaria by microscopy at 24 h between treatment arms (clinicaltrials.gov #NCT01708876). Enrolments started in December 2012, with completion expected by September 2014. A total sample size of 228 is required to give 90% power (α 0.05) to determine the primary end point using intention-to-treat analysis. Secondary end points include parasite clearance time, rates of recurrent infection/treatment failure to day 42, gametocyte carriage throughout follow-up and rates of anaemia at day 28, as determined by survival analysis. This study has been approved by relevant institutional ethics committees in Malaysia and Australia. Results will be disseminated to inform

  3. A prospective trial of customized adherence enhancement plus long-acting injectable antipsychotic medication in homeless or recently homeless individuals with schizophrenia or schizoaffective disorder

    Science.gov (United States)

    Sajatovic, Martha; Levin, Jennifer; Ramirez, Luis F.; Hahn, David Y.; Tatsuoka, Curtis; Bialko, Christopher S.; Cassidy, Kristin A.; Fuentes-Casiano, Edna; Williams, Tiffany D.

    2014-01-01

    Background Treatment non-adherence in people with schizophrenia is associated with relapse and homelessness. Building upon the usefulness of long-acting medication, and our work in psychosocial interventions to enhance adherence, we conducted a prospective uncontrolled trial of customized adherence enhancement (CAE) plus long-acting injectable antipsychotic (LAI) using haloperidol decanoate in 30 homeless or recently homeless individuals with schizophrenia and schizoaffective disorder. Methods Participants received monthly CAE and LAI (CAE-L) for 6 months. Primary outcomes were adherence as measured by the Tablets Routine Questionnaire (TRQ) and housing status. Secondary outcomes included psychiatric symptoms, functioning, side effects, and hospitalizations. Results Mean age of participants was 41.8 years (SD 8.6), mainly minorities (90% African-American) and mainly single/never married (70%). Most (97%) had past or current substance abuse, and had been incarcerated (97%). Ten individuals (33%) terminated the study prematurely. CAE-L was associated with good adherence to LAI (76% at 6 months) and dramatic improvement in oral medication adherence, which changed from missing 46% of medication at study enrollment to missing only 10% at study end (p = 0.03). There were significant improvements in psychiatric symptoms (pschizoaffective disorder. Additional research is needed on effective and practical approaches to improving health outcomes for homeless people with serious mental illness. PMID:24434094

  4. INTER-ACT: prevention of pregnancy complications through an e-health driven interpregnancy lifestyle intervention - study protocol of a multicentre randomised controlled trial.

    Science.gov (United States)

    Bogaerts, Annick; Ameye, Lieveke; Bijlholt, Margriet; Amuli, Kelly; Heynickx, Dorine; Devlieger, Roland

    2017-05-26

    Excessive maternal pre-pregnancy and gestational weight gain are related to pregnancy- and birth outcomes. The interpregnancy time window offers a unique opportunity to intervene in order to acquire a healthy lifestyle before the start of a new pregnancy. INTER-ACT is an e-health driven multicentre randomised controlled intervention trial targeting women at high risk of pregnancy- and birth related complications. Eligible women are recruited for the study at day 2 or 3 postpartum. At week 6 postpartum, participants are randomised into the intervention or control arm of the study. The intervention focuses on weight, diet, physical activity and mental well-being, and comprises face-to-face coaching, in which behavioural change techniques are central, and use of a mobile application, which is Bluetooth-connected to a weighing scale and activity tracker. The intervention is rolled out postpartum (4 coaching sessions between week 6 and month 6) and in a new pregnancy (3 coaching sessions, one in each trimester of pregnancy); the mobile app is used throughout the two intervention phases. Data collection includes data from the medical record of the participants (pregnancy outcomes and medical history), anthropometric data (height, weight, waist- and hip circumferences, skinfold thickness and body composition by bio-electrical impedance analysis), data from the mobile app (physical activity and weight; intervention group only) and questionnaires (socio-demographics, breastfeeding, food intake, physical activity, lifestyle, psychosocial factors and process evaluation). Medical record data are collected at inclusion and at delivery of the subsequent pregnancy. All other data are collected at week 6 and month 6 postpartum and every subsequent 6 months until a new pregnancy, and in every trimester in the new pregnancy. Primary outcome is the composite endpoint score of pregnancy-induced hypertension, gestational diabetes mellitus, caesarean section, and large

  5. Botulinum toxin: yesterday, today, tomorrow

    Directory of Open Access Journals (Sweden)

    A. R. Artemenko

    2013-01-01

    Full Text Available Botulinum toxin (BoNT is a bacterial neurotoxin presented with seven serotypes that inhibit neurotransmitter release from nerve endings. The serotypes of BoNT are antigenically dissimilar, act via different, but interconnected mechanisms, and are not interchangeable. The activity of BoNT is associated with impaired neuroexocytosis occurring in several steps: from the binding of BoNT to its specific receptor on the axon terminal membrane to the proteolytic enzymatic cleavage of SNARE substrate. The effect of BoNT is considered to be restricted to the peripheral nervous system, but when given in particularly high doses, it has been recently shown to affect individual brain structures. In addition, by modulating peripheral afferentation, BoNT may influence the excitability of central neuronal structures at both spinal and cortical levels. Only BoNT serotypes A and B are used in clinical practice and aesthetic medicine. The type A has gained the widest acceptance as a therapeutic agent for more than 100 abnormalities manifesting themselves as muscular hyperactivity, hyperfunction of endocrine gland, and chronic pain. The effect of BoNT preparations shows itself 2-5 days after injection, lasts 3 months or more, and gradually decreases with as a result of pharmacokinetic and intracellular reparative processes. Biotechnology advances and potentialities allow purposefully modification of the protein molecular structure of BoNT, which expands the use and efficiency of performed therapy with neurotoxins. Recombinant technologies provide a combination of major therapeutic properties of each used BoNT serotype and expand indications for recombinant chimeric toxins.

  6. One-year outcomes of a randomized controlled trial of housing first with ACT in five Canadian cities.

    Science.gov (United States)

    Aubry, Tim; Tsemberis, Sam; Adair, Carol E; Veldhuizen, Scott; Streiner, David; Latimer, Eric; Sareen, Jitender; Patterson, Michelle; McGarvey, Kathleen; Kopp, Brianna; Hume, Catharine; Goering, Paula

    2015-05-01

    Housing First is a groundbreaking approach to ending chronic homelessness among people with mental illness. This article presents one-year findings from a multisite randomized controlled trial (RCT) comparing Housing First with treatment as usual. The study was a nonblind, parallel-group RCT conducted in five Canadian cities. A sample of 950 high-need participants with severe mental illness, who were either absolutely homeless or precariously housed, was randomly assigned to Housing First (N=469) or treatment as usual (N=481). Housing First participants received a rent supplement, assistance to find housing, and assertive community treatment. Treatment-as-usual participants had access to all other existing programs. At one-year follow-up, 73% of Housing First participants and 31% of treatment-as-usual participants resided in stable housing (plife was significantly greater among Housing First participants compared with treatment-as-usual participants (pHousing First participants also showed greater improvements in community functioning compared with treatment-as-usual participants (p=.003, d=.25, CI=.09-.41). Compared with treatment as usual, Housing First produced greater improvements in housing stability, quality of life, and community functioning after one year of enrollment. The study provides support for adopting Housing First as an approach for ending chronic homelessness among persons with severe mental illness, even if they are actively symptomatic or using substances.

  7. Women in Energy: Rinku Gupta - Argonne Today

    Science.gov (United States)

    -performance clusters and supercomputers. What is the best part of your job? The best part is working with Argonne Today Argonne Today Mission People Work/Life Connections Focal Point Women in Energy: Rinku Gupta Home People Women in Energy: Rinku Gupta Women in Energy: Rinku Gupta Apr 1, 2016 | Posted by Argonne

  8. Clinical Trials

    Medline Plus

    Full Text Available ... studies. View funding information for clinical trials optimization . Building 31 31 Center Drive Bethesda, MD 20892 Learn ... and Usage No FEAR Act Grants and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn ...

  9. Clinical Trials

    Medline Plus

    Full Text Available ... and organizations also sponsor clinical trials. Examples include Government Agencies, such as the U.S. Departments of Defense ... FOIA) Accessibility Copyright and Usage No FEAR Act Grants and Funding Building 31 31 Center Drive Bethesda, ...

  10. School-based intervention to enable school children to act as change agents on weight, physical activity and diet of their mothers: a cluster randomized controlled trial.

    Science.gov (United States)

    Gunawardena, Nalika; Kurotani, Kayo; Indrawansa, Susantha; Nonaka, Daisuke; Mizoue, Tetsuya; Samarasinghe, Diyanath

    2016-04-06

    School health promotion has been shown to improve the lifestyle of students, but it remains unclear whether school-based programs can influence family health. We developed an innovative program that enables school children to act as change agents in promoting healthy lifestyles of their mothers. The objective of this study was to examine the effect of the child-initiated intervention on weight, physical activity and dietary habit of their mothers. A 12-month cluster randomized trial was conducted, with school as a cluster. Participants were mothers with grade 8 students, aged around 13 years, of 20 schools in Homagama, Sri Lanka. Students of the intervention group were trained by facilitators to acquire the ability to assess noncommunicable disease risk factors in their homes and take action to address them, whereas those of the comparison group received no intervention. Body weight, step count and lifestyle of their mothers were assessed at baseline and post-intervention. Multi-level multivariable linear regression and logistic regression were used to assess the effects of intervention on continuous and binary outcomes, respectively. Of 308 study participants, 261 completed the final assessment at 12 month. There was a significantly greater decrease of weight and increase of physical activity in the intervention group. The mean (95% confidence interval) difference comparing the intervention group with the control group was -2.49 (-3.38 to -1.60) kg for weight and -0.99 (-1.40 to -0.58) kg/m(2) for body mass index. The intervention group had a 3.25 (95% confidence interval 1.87-5.62) times higher odds of engaging in adequate physical activity than the control group, and the former showed a greater number of steps than the latter after intervention. The intervention group showed a greater reduction of household purchase of biscuits and ice cream. A program to motivate students to act as change agents of family's lifestyle was effective in decreasing weight and

  11. Augmenting cognitive training in older adults (The ACT Study): Design and Methods of a Phase III tDCS and cognitive training trial.

    Science.gov (United States)

    Woods, Adam J; Cohen, Ronald; Marsiske, Michael; Alexander, Gene E; Czaja, Sara J; Wu, Samuel

    2018-02-01

    Adults over age 65 represent the fastest growing population in the US. Decline in cognitive abilities is a hallmark of advanced age and is associated with loss of independence and dementia risk. There is a pressing need to develop effective interventions for slowing or reversing the cognitive aging process. While certain forms of cognitive training have shown promise in this area, effects only sometimes transfer to neuropsychological tests within or outside the trained domain. This paper describes a NIA-funded Phase III adaptive multisite randomized clinical trial, examining whether transcranial direct current stimulation (tDCS) of frontal cortices enhances neurocognitive outcomes achieved from cognitive training in older adults experiencing age-related cognitive decline: the Augmenting Cognitive Training in Older Adults study (ACT). ACT will enroll 360 participants aged 65 to 89 with age-related cognitive decline, but not dementia. Participants will undergo cognitive training intervention or education training-control combined with tDCS or sham tDCS control. Cognitive training employs a suite of eight adaptive training tasks focused on attention/speed of processing and working memory from Posit Science BrainHQ. Training control involves exposure to educational nature/history videos and related content questions of the same interval/duration as the cognitive training. Participants are assessed at baseline, after training (12weeks), and 12-month follow-up on our primary outcome measure, NIH Toolbox Fluid Cognition Composite Score, as well as a comprehensive neurocognitive, functional, clinical and multimodal neuroimaging battery. The findings from this study have the potential to significantly enhance efforts to ameliorate cognitive aging and slow dementia. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Connected minds technology and today's learners

    CERN Document Server

    Pedrò, Francesc

    2012-01-01

    In all OECD countries, digital media and connectedness are integral to the lives of todays learners. It is often claimed that these learners are ""new millennium learners"", or ""digital natives"", who have different expectations about education. This book contributes to the debate about the effects of technology attachment and connectedness on todays learners, and their expectations about teaching. The book sets out to answer the following questions: Can the claim that todays students are ""new millenium learners"" or ""digital natives be sustained empirically? Is there consistent research evidence demonstrating the effects of technology on cognitive development, social values, and learning expectations? What are the implications for educational policy and practice?

  13. Onset of efficacy and tolerability following the initiation dosing of long-acting paliperidone palmitate: post-hoc analyses of a randomized, double-blind clinical trial

    Directory of Open Access Journals (Sweden)

    Fu Dong-Jing

    2011-05-01

    Full Text Available Abstract Background Paliperidone palmitate is a long-acting injectable atypical antipsychotic for the acute and maintenance treatment of adults with schizophrenia. The recommended initiation dosing regimen is 234 mg on Day 1 and 156 mg on Day 8 via intramuscular (deltoid injection; followed by 39 to 234 mg once-monthly thereafter (deltoid or gluteal. These post-hoc analyses addressed two commonly encountered clinical issues regarding the initiation dosing: the time to onset of efficacy and the associated tolerability. Methods In a 13-week double-blind trial, 652 subjects with schizophrenia were randomized to paliperidone palmitate 39, 156, or 234 mg (corresponding to 25, 100, or 150 mg equivalents of paliperidone, respectively or placebo (NCT#00590577. Subjects randomized to paliperidone palmitate received 234 mg on Day 1, followed by their randomized fixed dose on Day 8, and monthly thereafter, with no oral antipsychotic supplementation. The onset of efficacy was defined as the first timepoint where the paliperidone palmitate group showed significant improvement in the Positive and Negative Syndrome Scale (PANSS score compared to placebo (Analysis of Covariance [ANCOVA] models and Last Observation Carried Forward [LOCF] methodology without adjusting for multiplicity using data from the Days 4, 8, 22, and 36 assessments. Adverse event (AE rates and relative risks (RR with 95% confidence intervals (CI versus placebo were determined. Results Paliperidone palmitate 234 mg on Day 1 was associated with greater improvement than placebo on Least Squares (LS mean PANSS total score at Day 8 (p = 0.037. After the Day 8 injection of 156 mg, there was continued PANSS improvement at Day 22 (p ≤ 0.007 vs. placebo and Day 36 (p Conclusions Significantly greater symptom improvement was observed by Day 8 with paliperidone palmitate (234 mg on Day 1 compared to placebo; this effect was maintained after the 156 mg Day 8 injection, with a trend towards a dose

  14. Wood biomass gasification in the world today

    International Nuclear Information System (INIS)

    Nikolikj, Ognjen; Perishikj, Radovan; Mikulikj, Jurica

    1999-01-01

    Today gasification technology of different kinds represents a more and more interesting option of the production of energy forms. The article describes a biomass gasification plant (waste wood) Sydkraft, Vernamo from Sweden. (Author)

  15. Review of Huebert’s Libertarianism Today

    OpenAIRE

    Walter E. Block

    2010-01-01

    Libertarianism Today, by Jacob Huebert (Santa Barbara, CA: Praeger, 2010), is an excellent introduction to libertarianism. In contrast to many other recent books about libertarianism, a consistent non-compromising libertarianism is defended throughout this book.

  16. The evolving DOT enterprise : today toward tomorrow.

    Science.gov (United States)

    2013-04-01

    Departments of transportation (DOTs) today are being shaped by a wide range of : factors some of which are directly managed and controlled within the transportation : industry while others are external factors shaping the demand for transportatio...

  17. Effect of Deploying Trained Community Based Reproductive Health Nurses (CORN) on Long-Acting Reversible Contraception (LARC) Use in Rural Ethiopia: A Cluster Randomized Community Trial.

    Science.gov (United States)

    Zerfu, Taddese Alemu; Ayele, Henok Taddese; Bogale, Tariku Nigatu

    2018-06-01

    To investigate the effect of innovative means to distribute LARC on contraceptive use, we implemented a three arm, parallel groups, cluster randomized community trial design. The intervention consisted of placing trained community-based reproductive health nurses (CORN) within health centers or health posts. The nurses provided counseling to encourage women to use LARC and distributed all contraceptive methods. A total of 282 villages were randomly selected and assigned to a control arm (n = 94) or 1 of 2 treatment arms (n = 94 each). The treatment groups differed by where the new service providers were deployed, health post or health center. We calculated difference-in-difference (DID) estimates to assess program impacts on LARC use. After nine months of intervention, the use of LARC methods increased significantly by 72.3 percent, while the use of short acting methods declined by 19.6 percent. The proportion of women using LARC methods increased by 45.9 percent and 45.7 percent in the health post and health center based intervention arms, respectively. Compared to the control group, the DID estimates indicate that the use of LARC methods increased by 11.3 and 12.3 percentage points in the health post and health center based intervention arms. Given the low use of LARC methods in similar settings, deployment of contextually trained nurses at the grassroots level could substantially increase utilization of these methods. © 2018 The Population Council, Inc.

  18. Dose-associated changes in safety and efficacy parameters observed in a 24-week maintenance trial of olanzapine long-acting injection in patients with schizophrenia

    Directory of Open Access Journals (Sweden)

    Watson Susan B

    2011-02-01

    Full Text Available Abstract Background In a recently published 24-week maintenance study of olanzapine long-acting injection (LAI in schizophrenia (Kane et al., 2010, apparent dose-associated changes were noted in both efficacy and safety parameters. To help clinicians balance safety and efficacy when choosing a dose of olanzapine LAI, we further studied these changes. Methods Outpatients with schizophrenia who had maintained stability on open-label oral olanzapine for 4 to 8 weeks were randomly assigned to "low" (150 mg/2 weeks; N = 140, "medium" (405 mg/4 weeks; N = 318, or "high" (300 mg/2 weeks; N = 141 dosages of olanzapine LAI for 24 weeks. Potential relationships between dose and several safety or efficacy measures were examined via regression analysis, the Jonckheere-Terpstra test (continuous data, or the Cochran-Armitage test (categorical data. Results Safety parameters statistically significantly related to dose were mean weight change (low: +0.67 [SD = 4.38], medium: +0.89 [SD = 3.87], high: +1.70 [SD = 4.14] kg, p = .024; effect size [ES] = 0.264 high vs. low dose, mean change in prolactin (low: -5.61 [SD = 12.49], medium: -2.76 [SD = 19.02], high: +3.58 [SD = 33.78] μg/L, p = .001; ES = 0.410 high vs. low dose, fasting triglycerides change from normal at baseline to high (low: 3.2%, medium: 6.0%, high: 18.9%, p = .001; NNT = 7 high vs. low dose and fasting high-density lipoprotein cholesterol change from normal at baseline to low (low: 13.8%, medium: 19.6%, high: 30.7%, p = .019; NNT = 6 high vs. low dose. Efficacy measures significantly related to dose included Positive and Negative Syndrome Scale total score mean change (low: +2.66 [SD = 14.95], medium: -0.09 [SD = 13.47], high: -2.19 [SD = 13.11], p Conclusions Analyses of several safety and efficacy parameters revealed significant associations with dose of olanzapine LAI, with the highest dose generally showing greater efficacy as well as greater adverse changes in metabolic safety measures. When

  19. Effect of omalizumab on angioedema in H1 -antihistamine-resistant chronic spontaneous urticaria patients: results from X-ACT, a randomized controlled trial.

    Science.gov (United States)

    Staubach, P; Metz, M; Chapman-Rothe, N; Sieder, C; Bräutigam, M; Canvin, J; Maurer, M

    2016-08-01

    Chronic spontaneous urticaria (CSU) severely impacts quality of life (QoL), especially in patients with wheals and angioedema. Omalizumab is approved as add-on therapy for CSU patients; however, its effect on patients who are double-positive for wheals and angioedema has not been systematically studied. The primary objective was to evaluate the efficacy of omalizumab vs placebo at week 28 using the Chronic Urticaria Quality of Life (CU-Q2oL) questionnaire. Number of angioedema-burdened days, time interval between successive angioedema episodes, disease activity, angioedema-specific and overall QoL impairment were secondary objectives. X-ACT was a phase III, randomized, double-blind study conducted in 24 centres (Germany), which selectively included CSU patients with angioedema and wheals. Patients were randomized (1 : 1) to omalizumab 300 mg or placebo (every 4 weeks up to week 24) (ClinicalTrials.gov number: NCT01723072). Of the 91 patients randomized to omalizumab (n = 44) or placebo (n = 47) at baseline, 68 completed the 28-week treatment phase (omalizumab, 35; placebo, 33). Omalizumab was superior to placebo in improving CU-Q2oL scores at week 28 (P omalizumab (0.3) vs placebo (1.1). The median time to first recurrence of angioedema was 57-63 days with omalizumab and Omalizumab significantly improved angioedema-specific QoL (P omalizumab. Omalizumab was an effective treatment option for patients with moderate-to-severe CSU symptoms and angioedema unresponsive to high doses of antihistamine treatment. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte Oncology Network

    Directory of Open Access Journals (Sweden)

    Ciuffreda Libero

    2009-11-01

    Full Text Available Abstract Background Well-differentiated neuroendocrine carcinomas are highly vascularized and may be sensitive to drugs administered on a metronomic schedule that has shown antiangiogenic properties. A phase II study was designed to test the activity of protracted 5-fluorouracil (5FU infusion plus long-acting release (LAR octreotide in patients with neuroendocrine carcinoma. Methods Twenty-nine patients with metastatic or locally advanced well-differentiated neuroendocrine carcinoma were treated with protracted 5FU intravenous infusion (200 mg/m2 daily plus LAR octreotide (20 mg monthly. Patients were followed for toxicity, objective response, symptomatic and biochemical response, time to progression and survival. Results Assessment by Response Evaluation Criteria in Solid Tumors (RECIST criteria showed partial response in 7 (24.1%, stable disease in 20 (69.0%, and disease progression in 2 patients. Response did not significantly differ when patients were stratified by primary tumor site and proliferative activity. A biochemical (chromogranin A response was observed in 12/25 assessable patients (48.0%; symptom relief was obtained in 9/15 symptomatic patients (60.0%. There was non significant decrease in circulating vascular epithelial growth factor (VEGF over time. Median time to progression was 22.6 months (range, 2.7-68.5; median overall survival was not reached yet. Toxicity was mild and manageable. Conclusion Continuous/metronomic 5FU infusion plus LAR octreotide is well tolerated and shows activity in patients with well-differentiated neuroendocrine carcinoma. The potential synergism between metronomic chemotherapy and antiangiogenic drugs provides a rationale for exploring this association in the future. Trial registration NCT00953394

  1. Participatory management in today's health care setting

    International Nuclear Information System (INIS)

    Burnham, B.A.

    1987-01-01

    As the health care revolution progresses, so must the management styles of today's leaders. The authors must ask ourselves if we are managing tomorrow's work force or the work force of the past. Participatory management may better meet the needs of today's work force. This paper identifies the reasons participatory management is a more effective management style, the methods used to implement a participatory management program, its benefits (such as higher productivity and more efficient, effective implementation and acceptance of change), and the difficulties experienced

  2. Film Presentation: Projekt Zukunft/Tomorrow Today

    CERN Multimedia

    Carolyn Lee

    2010-01-01

    Projekt Zukunft/Tomorrow Today, by Deutsche Welle (2009)   Deutsche Welle TV’s weekly science journal explores the LHC at CERN with host Ingolf Baur. Please note that we will show both the German and English versions of this broadcast. Each episode is about 27 minutes long. Projekt Zukunft/Tomorrow Today will be presented on Friday, 29 October from 13:00 to 14:00 in the Main Auditorium Language: German version followed by the English version      

  3. The Geriatric Child in Today's Culture.

    Science.gov (United States)

    Lamson, Frank E.

    This paper develops the premise that there is today a new "child" in our culture developed in response to expectations of daily functioning, family relationships, societal status, economic level, medical illness, emotional needs, and financial management. This new "child" is a person who has usually passed the age of 65, and has found that the…

  4. Using Today's Headlines for Teaching Gerontology

    Science.gov (United States)

    Haber, David

    2008-01-01

    It is a challenge to attract undergraduate students into the gerontology field. Many do not believe the aging field is exciting and at the cutting edge. Students, however, can be convinced of the timeliness, relevance, and excitement of the field by, literally, bringing up today's headlines in class. The author collected over 250 articles during…

  5. The energy of today and tomorrow

    International Nuclear Information System (INIS)

    Bauquis, E.; Bauquis, P.R.

    2007-01-01

    The authors present a today state of the art concerning the energy domain in the world, offering perspectives on what could be the tomorrow world in matter of energy. They define fundamental notions, the different sources of energy and their price, the energy policies of the different countries and the problem of the consumption impact on the environment. (A.L.B.)

  6. The Genetic Code: Yesterday, Today and Tomorrow

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 12. The Genetic Code: Yesterday, Today and Tomorrow. Jiqiang Ling Dieter Söll. General Article Volume 17 Issue 12 December 2012 pp 1136-1142. Fulltext. Click here to view fulltext PDF. Permanent link:

  7. We, John Dewey's Audience of Today

    Science.gov (United States)

    da Cunha, Marcus Vinicius

    2016-01-01

    This article suggests that John Dewey's "Democracy and Education" does not describe education in an existing society, but it conveys a utopia, in the sense coined by Mannheim: utopian thought aims at instigating actions towards the transformation of reality, intending to attain a better world in the future. Today's readers of Dewey (his…

  8. Organization management today: setting the human resource ...

    African Journals Online (AJOL)

    The paper's discussion focuses on the way the world we live in is being transformed under our own very eyes by factors and forces which are so compelling and overwhelming, in their ramifications. The environment in which business and management are carried on today is becoming more and more complex by the day.

  9. Europa Heute: Filmbegleitheft (Europe Today: Film Manual).

    Science.gov (United States)

    Freudenstein, Reinhold; And Others

    This teacher's guide to the German promotional film "Europe Today", suitable for use in advanced courses, concentrates on linguistic preparation required for full appreciation. The film focuses on the role of European countries as participating members of the Common Market. The manual includes information on the German film industry, a…

  10. Southern forests: Yesterday, today, and tomorrow

    Science.gov (United States)

    R. Neil Sampson

    2004-01-01

    In the 20th century, southern forests changed dramatically. Those changes pale, however, when compared to what happened to the people of the region. In addition to growing over fourfold in numbers, the South's population has urbanized, globalized, and intellectualized in 100 years. Rural and isolated in the 19th century, they are today urban and cosmopolitan. One...

  11. Identity and Diversity in Today's World

    Science.gov (United States)

    Gee, James Paul

    2017-01-01

    This paper develops a thesis about identity and diversity. I first look at activity-based identities, identities like being a gardener, birder, citizen scientist or fan-fiction writer. These are freely chosen identities and they are proliferating at a great rate today thanks to participatory culture, the Maker Movement and digital and social…

  12. Applying Servant Leadership in Today's Schools

    Science.gov (United States)

    Culver, Mary K.

    2009-01-01

    This book illustrates how the ideal of servant leadership can be applied in your school today. With real-life scenarios, discussions, and self assessments, this book gives practical suggestions to help you develop into a caring and effective servant leader. There are 52 scenarios in this book, focusing on situations as varied as: (1) Dealing with…

  13. Primary School Leadership Today and Tomorrow

    Science.gov (United States)

    Southworth, Geoff

    2008-01-01

    The article provides a retrospective and prospective view of primary school leadership. It begins with an analytic description of primary school leadership in the recent past. The second part looks at school leadership today, identifies contemporary issues and examines role continuities and changes. The third part looks at what the future might…

  14. After the Resistance: The Alamo Today

    Centers for Disease Control (CDC) Podcasts

    2014-09-23

    Byron Breedlove reads his essay After the Resistance: The Alamo Today about the Alamo and emerging disease resistance.  Created: 9/23/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 10/20/2014.

  15. Secondary School Administration in Anambra State Today ...

    African Journals Online (AJOL)

    The study, a descriptive survey research design was used to identify the challenges that impede secondary school administration today in Anambra State. The population of the study was all the 259 public secondary school principals in the state. Two research questions and two null hypotheses guided the study. A 20-item ...

  16. A randomized clinical trial of the effect of intensive versus non-intensive counselling on discontinuation rates due to bleeding disturbances of three long-acting reversible contraceptives.

    Science.gov (United States)

    Modesto, Waleska; Bahamondes, M Valeria; Bahamondes, Luis

    2014-07-01

    Does intensive counselling before insertion and throughout the first year of use have any influence on discontinuation rates due to unpredictable menstrual bleeding in users of three long-acting reversible contraceptives (LARCs)? Intensive counselling had a similar effect to routine counselling in terms of discontinuation rates due to unpredictable menstrual bleeding in new users of the contraceptives. Contraceptive efficacy and satisfaction rates are very high with LARCs, including the etonogestrel (ENG)-releasing implant, the levonorgestrel-releasing intrauterine system (LNG-IUS) and the TCu380A intrauterine device (IUD). However, unpredictable menstrual bleeding constitutes the principal reason for premature discontinuation, particularly in the cases of the ENG-implant and the LNG-IUS. A randomized clinical trial was conducted between 2011 and 2013, and involved 297 women: 98 ENG-implant users, 99 LNG-IUS users and 100 TCu380A IUD users. Women accepting each contraceptive method were randomized into two groups after the women chose their contraceptive method. Group I received routine counselling at the clinic, including information on safety, efficacy and side effects, as well as what to expect regarding bleeding disturbances. Group II received 'intensive counselling'. In addition to the information provided to those in Group I, these women also received leaflets on their chosen method and were seen by the same three professionals, the most experienced at the clinic, throughout the year of follow-up. These three professionals went over all the information provided at each consultation. Women in both groups were instructed to return to the clinic after 45 (±7) days and at 6 and 12 (±1) months after insertion. They were instructed to record all bleeding episodes on a menstrual calendar specifically provided for this purpose. Additionally, satisfaction with the method was evaluated by a questionnaire completed by the women after 12 months of use of the

  17. Einstein today; Einstein aujourd'hui

    Energy Technology Data Exchange (ETDEWEB)

    Aspect, A.; Grangier, Ph. [Centre National de la Recherche Scientifique (CNRS), Lab. Charles Fabry de l' Institut d' Optique a Orsay, 91 - Orsay (France); Bouchet, F.R. [Institut d' Astrophysique de Paris, CNRS, 75 - Paris (France); Brunet, E.; Derrida, B. [Universite Pierre et Marie Curie, Ecole Normale Superieure, 75 - Paris (France); Cohen-Tannoudji, C. [Academie des Sciences, 75 - Paris (France); Dalibard, J.; Laloe, F. [Laboratoire Kastler Brossel. UMR 8552 (ENS, UPMC, CNRS), 75 - Paris (France); Damour, Th. [Institut des Hautes Etudes Scientifiques, 91 - Bures sur Yvette (France); Darrigol, O. [Centre National de la Recherche Scientifique (CNRS), Groupe Histoire des Sciences Rehseis, 75 - Paris (France); Pocholle, J.P. [Thales Research et Technology France, 91 - Palaiseau (France)

    2005-07-01

    The most important contributions of Einstein involve 5 fields of physics : the existence of quanta (light quanta, stimulated radiation emission and Bose-Einstein condensation), relativity, fluctuations (Brownian motion and thermodynamical fluctuations), the basis of quantum physics and cosmology (cosmological constant and the expansion of the universe). Diverse and renowned physicists have appreciated the development of modern physics from Einstein's ideas to the knowledge of today. This book is a collective book that gathers their work under 7 chapters: 1) 1905, a new beginning; 2) from the Einstein, Podolsky and Rosen's article to quantum information (cryptography and quantum computers); 3) the Bose-Einstein condensation in gases; 4) from stimulated emission to the today's lasers; 5) Brownian motion and the fluctuation-dissipation theory; 6) general relativity; and 7) cosmology. (A.C.)

  18. Alternative motor fuels today and tomorrow

    International Nuclear Information System (INIS)

    Bensaid, B.

    2004-01-01

    Today, petroleum products account for 97% of the energy consumed in road transport. The purpose of replacing these products with alternative energies is to reduce oil dependence as well as greenhouse gas emissions. The high price of oil has promoted the use of 'conventional' alternative motor fuels (biofuels, LPG, NGV) and also renewed interest in syn-fuels (GTL, CTL, BTL) that have already given rise to industrial and pilot projects. (author)

  19. EURO - Before Yesterday, Yesterday, Today, Tomorrow...

    OpenAIRE

    Sylwia Pangsy-Kania

    2002-01-01

    The article was divided into four integrally connected parts concerning the EURO: before yesterday, yesterday, today and tomorrow. On the 1st January 2002 the common European currency became a fact. In eleven European countries there appeared jointly over 13 billion banknotes and 76 billion coins. The introduction of a common currency in the countries of the European Union is the greatest financial operation in world history with such a huge scale and degree of complication. Before yesterdayŠ...

  20. E-learning. Today and tomorrow

    International Nuclear Information System (INIS)

    Gelbke, Silvana

    2010-01-01

    Today, new technologies revolutionize the way of handling information, exchanging knowledge and learning. The definition of the term ''e-learning'' mostly comprehends teaching and learning using a range of electronic media (Internet, CD-ROMs). However, further differentiation is necessary to describe the entire spectrum of methods included in this term. These different approaches are reflected in their implementation by the companies presented. (orig.)

  1. The Prospects of Radical Change Today

    Directory of Open Access Journals (Sweden)

    Slavoj Žižek

    2018-05-01

    Full Text Available In this contribution, Slavoj Žižek takes the occasion of Marx’s bicentenary for reflecting on the prospects of radical change today. First, it is shown that under Stalinism, Lenin’s works were quoted out of context in an arbitrary way in order to legitimise arbitrary political measures. Marxism thereby became an ideology that justified brutal subjective interventions. Second, this contribution poses the question of the revolutionary subject and democracy today. It stresses the role of both contingency and strategy in revolutions. In political assemblages taking place on public squares, the inert mass of ordinary people is transubstantiated into a politically engaged united force. The basic political problem today is how to best reconfigure democracy. Third, this contribution analyses the “interesting times” we live in. These are times that feature multiple crises, right-wing populism à la Donald Trump and Marine Le Pen, the lower classes’ opposition to immigration, and the refugee crisis. Questions about human rights and their violation and about radical change need to be asked in this context.

  2. Privacy Act

    Science.gov (United States)

    Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

  3. Everolimus and long acting octreotide as a volume reducing treatment of polycystic livers (ELATE: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Chrispijn Melissa

    2011-11-01

    Full Text Available Abstract Background Polycystic liver disease (PLD is defined as having more than 20 liver cysts and can present as a severe and disabling condition. Most symptoms are caused by the mass effect of the liver size and include abdominal pain and distension. The somatostatin analogues octreotide and lanreotide have proven to reduce polycystic liver volume. mTOR inhibitors such as everolimus inhibit cell proliferation and might thereby reduce growth of liver cysts. This trial aims to assess the benefit of combination therapy of everolimus and octreotide compared to octreotide monotherapy. In this study we present the structure of the trial and the characteristics of the included patients. Methods/design This is a randomized open-label clinical trial comparing the effect of 12 months of everolimus and octreotide to octreotide monotherapy in PLD patients. Primary outcome is change in liver volume determined by CT-volumetry. Secondary outcomes are changes in abdominal symptoms and quality of life. Moreover, safety and tolerability of the drugs will be assessed. Discussion This trial will compare the relative efficacy of combination therapy with octreotide and everolimus to octreotide monotherapy. Since they apply to different pathways of cystogenesis we expect that combining octreotide and everolimus will result in a cumulative reduction of polycystic liver volume. Trial registration number ClinicalTrials.gov: NCT01157858

  4. Corrosion issues in nuclear industry today

    International Nuclear Information System (INIS)

    Cattant, F.; Crusset, D.; Feron, D.

    2008-01-01

    In the context of global warming, nuclear energy is a carbon-free source of power and so is a meaningful option for energy production without CO 2 emissions. Currently, there are more than 440 commercial nuclear reactors, accounting for about 15% of electric power generation in the world, and there has not been a major accident in over 20 years. The world's fleet of nuclear power plants is, on average, more than 20 years old. Even though the design life of a nuclear power plant is typically 30 or 40 years, it is quite feasible that many nuclear power plants will be able to operate for longer than this. The re-emergence of nuclear power today is founded on the present generation of nuclear reactors meeting the demands of extended service life, ensuring the cost competitiveness of nuclear power and matching enhanced safety requirements. Nuclear power plant engineers should be able to demonstrate such integrity and reliability of their system materials and components as to enable nuclear power plants to operate beyond their initial design life. Effective waste management is another challenge for sustainable nuclear energy today; more precisely, a solution is needed for the management of high-level and long-lived intermediate-level radioactive waste over the very long term. Most nuclear countries are currently gathering the data needed to assess the feasibility of a deep geological waste repository, including the prediction of the behaviour of materials over several thousands of years. The extended service life of nuclear power plants and the need for permanent disposal for nuclear waste are today's key issues in the nuclear industry. We focus here on the major role that corrosion plays in these two factors, and on the French approaches to these two issues. (authors)

  5. Global aromatics supply. Today and tomorrow

    Energy Technology Data Exchange (ETDEWEB)

    Bender, M. [BASF SE, Ludwigshafen (Germany)

    2013-11-01

    Aromatics are the essential building blocks for some of the largest petrochemical products in today's use. To the vast majority they are consumed to produce intermediates for polymer products and, hence, contribute to our modern lifestyle. Their growth rates are expected to be in line with GDP growth in future. This contrasts the significantly lower growth rates of the primary sources for aromatics - fuel processing and steam cracking of naphtha fractions. A supply gap can be expected to open up in future for which creative solutions will be required. (orig.)

  6. Perspectives on Gandhi’s Significance Today

    Directory of Open Access Journals (Sweden)

    Michael Simpson

    2016-12-01

    Full Text Available Gandhi’s example has inspired countless political struggles worldwide over the past century. We might then ask how his thought has been transferred and translated when taken out of the particular historical and geographic context in which he lived. How have Gandhi’s ideas been changed or altered when adopted in different contexts? Which aspects of Gandhi’s thinking remain most relevant to struggles for social and environmental justice today? These are just a few of the questions that were discussed at the “Perspectives on Gandhi’s Significance Workshop” hosted by Reed College in Portland Oregon (USA, on April 16th, 2016.

  7. Nature and history today: the ecological crisis

    Directory of Open Access Journals (Sweden)

    Luciano ESPINOSA RUBIO

    2012-02-01

    Full Text Available Today, the Nature-History relations are the ecological ones: we are living in a global eco-bio-techno-noos-sphere and that means that ecological crisis is a crisis of civilization too. Above all, the climate change and its social and political consequences will have a great impact in our lives, and we must respond without losing our rights. In the intellectual way, we need new narrations in order to affront the situation and perhaps the theory of the lesser evil is one of the better answers that we can find.

  8. Ideologies in the Swedish health sector today

    DEFF Research Database (Denmark)

    Diderichsen, Finn

    1982-01-01

    Sweden has a long tradition of social democracy and corporate cooperation. Social problems are treated as technological questions that always should be solved through rational and neutral means. Today Sweden faces a crisis of economy as well as a crisis of medicine. In the spirit of consensus, th...... system of primary care and prevention. However, in the context of the current economic crisis, the struggle against health hazards and cuts in public spending has intensified and the gap between the ideology of technological rationalism and reality has widened....

  9. The ASME Code today -- Challenges, threats, opportunities

    International Nuclear Information System (INIS)

    Canonico, D.A.

    1995-01-01

    Since its modest beginning as a single volume in 1914 the ASME Code, or some of its parts, is recognized today in 48 of the United States and all providence's of Canada. The ASME Code today is composed of 25 books including two Code Case books. These books cover the new construction of boilers and pressure vessels and the new construction and In-Service-Inspection of Nuclear Power Plant components. The ASME accredits all manufacturers of boilers and pressure vessels built to the ASME Code. There are approximately 7650 symbol stamps issued throughout the world. Over 23% of the symbol stamps have been issued outside the USA and Canada. The challenge to the ASME Code is to be accepted as the world standard for pressure boundary components. There are activities underway to achieve that goal. The ASME Code is being revised to make it a more friendly document to entities outside of North America. To achieve that end there are specific tasks underway which are described here

  10. Gilson, Krapiec and Christian Philosophy Today

    Directory of Open Access Journals (Sweden)

    Pawel Tarasiewicz

    2015-12-01

    Full Text Available The author undertakes an attempt to answer the following question: is Christian philosophy possible today? The question seems to be of great importance due to the fact that what Christians who try to do philosophy usually encounter is bitter criticism which comes to them from two sides at once: that of academy and that of the Church. In short, for academy their philosophy is too Christian, and for the Church it is too academic. Being indebted to the insights of Étienne Gilson and Mieczyslaw A. Krapiec (the original Polish spelling: Mieczysław Albert Krąpiec, pronounced: myechisuaf albert krompyetz, the author comes to the conclusion thatChristian philosophy is possible today only if: 1 it isnot identified with the art of persuasion, as its final end lies in gaining understanding rather than being convincing, 2 itis the work of a Christian, and 3 it has thereal world as its object and metaphysics as its method. ForChristian philosophy—which in essence consists indoing philosophy by Christians in order to get morerational understanding of their religious faith—shouldbe identified with theperfection of the intellect achieved by practicingthe classical philosophy of being.

  11. Lecture programme The reality of science today

    CERN Multimedia

    2007-01-01

    What are the new challenges and realities facing scientific research? What is its place in society today? To answer these questions, the History and Philosophy of Sciences Unit of Geneva University, in collaboration with ASPERA, the European network for astroparticle physics research, has organised a programme of lectures entitled La réalité de la science d’aujourd’hui, enjeux et défis de la diversité. This series of lectures will provide researchers and members of the public with a snapshot of the state of science today from the perspective of laboratories and institutes, and on subjects such as funding policy and technological and legal impact. The first lecture will be given by science historian Dominique Pestre (EHESS & Centre Koyré, Paris), renowned for his contributions to the analysis of science past and present, and notably one of the authors of the work "History of CERN". He will discuss the modern methods of producing scientific knowledge which have been develop...

  12. Liver transplantation:Yesterday,today and tomorrow

    Institute of Scientific and Technical Information of China (English)

    Osman Abbasoglu

    2008-01-01

    With the advances in technical skills,management of postoperative complications and improvements in immunosuppressive drugs,liver transplantation is the standard treatment for many patients with chronic liver disease.Today,shortage of donor organs seems to be the major limiting factor for the application of liver transplantation.This review focuses on five issues that are challenging to clinical practice of liver transplantation and relevant to gastroenterologists.These include living donor liver transplantation,recurrent viral hepatitis,non-heart-beating donors,hepatocellular carcinoma,and ABO incompatible livertransplantation.Living donor and non-heart beating donor transplantations were initiated as a solution to increase the donor organ pool and it is expected that there will be an increase in the number of these donors.Recurrent hepatitis C and hepatocellular carcinoma following liver transplantation are among major problems and ongoing research in these diseases may lead to better outcomes in these recipients.

  13. Global public health today: connecting the dots

    Directory of Open Access Journals (Sweden)

    Marta Lomazzi

    2016-02-01

    Full Text Available Background: Global public health today faces new challenges and is impacted by a range of actors from within and outside state boundaries. The diversity of the actors involved has created challenges and a complex environment that requires a new context-tailored global approach. The World Federation of Public Health Associations has embarked on a collaborative consultation with the World Health Organization to encourage a debate on how to adapt public health to its future role in global health. Design: A qualitative study was undertaken. High-level stakeholders from leading universities, multilateral organizations, and other institutions worldwide participated in the study. Inductive content analyses were performed. Results: Stakeholders underscored that global public health today should tackle the political, commercial, economic, social, and environmental determinants of health and social inequalities. A multisectoral and holistic approach should be guaranteed, engaging public health in broad dialogues and a concerted decision-making process. The connection between neoliberal ideology and public health reforms should be taken into account. The WHO must show leadership and play a supervising and technical role. More and better data are required across many programmatic areas of public health. Resources should be allocated in a sustainable and accountable way. Public health professionals need new skills that should be provided by a collaborative global education system. A common framework context-tailored to influence governments has been evaluated as useful. Conclusions: The study highlighted some of the main public health challenges currently under debate in the global arena, providing interesting ideas. A more inclusive integrated vision of global health in its complexity, shared and advocated for by all stakeholders involved in decision-making processes, is crucial. This vision represents the first step in innovating public health at the

  14. Global public health today: connecting the dots

    Science.gov (United States)

    Lomazzi, Marta; Jenkins, Christopher; Borisch, Bettina

    2016-01-01

    Background Global public health today faces new challenges and is impacted by a range of actors from within and outside state boundaries. The diversity of the actors involved has created challenges and a complex environment that requires a new context-tailored global approach. The World Federation of Public Health Associations has embarked on a collaborative consultation with the World Health Organization to encourage a debate on how to adapt public health to its future role in global health. Design A qualitative study was undertaken. High-level stakeholders from leading universities, multilateral organizations, and other institutions worldwide participated in the study. Inductive content analyses were performed. Results Stakeholders underscored that global public health today should tackle the political, commercial, economic, social, and environmental determinants of health and social inequalities. A multisectoral and holistic approach should be guaranteed, engaging public health in broad dialogues and a concerted decision-making process. The connection between neoliberal ideology and public health reforms should be taken into account. The WHO must show leadership and play a supervising and technical role. More and better data are required across many programmatic areas of public health. Resources should be allocated in a sustainable and accountable way. Public health professionals need new skills that should be provided by a collaborative global education system. A common framework context-tailored to influence governments has been evaluated as useful. Conclusions The study highlighted some of the main public health challenges currently under debate in the global arena, providing interesting ideas. A more inclusive integrated vision of global health in its complexity, shared and advocated for by all stakeholders involved in decision-making processes, is crucial. This vision represents the first step in innovating public health at the global level and should lead

  15. From Fayol's Mechanistic to Today's Organic Functions of Management

    Science.gov (United States)

    McNamara, Daniel E.

    2009-01-01

    This paper reviews Fayol's original five managerial functions, demonstrates that they are still being taught in today's management courses, and offers a new set of organic management functions more applicable to today's turbulent business environment.

  16. Managing previously disposed waste to today's standards

    International Nuclear Information System (INIS)

    1990-01-01

    A Radioactive Waste Management Complex (RWMC) was established at the Idaho National Engineering Laboratory (INEL) in 1952 for controlled disposal of radioactive waste generated at the INEL. Between 1954 and 1970 waste characterized by long lived, alpha emitting radionuclides from the Rocky Flats Plant was also buried at this site. Migration of radionuclides and other hazardous substances from the buried Migration of radionuclides and other hazardous substances from the buried waste has recently been detected. A Buried Waste Program (BWP) was established to manage cleanup of the buried waste. This program has four objectives: (1) determine contaminant sources, (2) determine extent of contamination, (3) mitigate migration, and (4) recommend an alternative for long term management of the waste. Activities designed to meet these objectives have been under way since the inception of the program. The regulatory environment governing these activities is evolving. Pursuant to permitting activities under the Resource Conservation and Recovery Act (RCRA), the Department of Energy (DOE) and the Environmental Protection Agency (EPA) entered into a Consent Order Compliance Agreement (COCA) for cleanup of past practice disposal units at the INEL. Subsequent to identification of the RWMC as a release site, cleanup activities proceeded under dual regulatory coverage of RCRA and the Atomic Energy Act. DOE, EPA, and the State of Idaho are negotiating a RCRA/Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Interagency Agreement (IAG) for management of waste disposal sites at the INEL as a result of the November 1989 listing of the INEL on the National Priority List (NPL). Decision making for selection of cleanup technology will be conducted under the CERCLA process supplemented as required to meet the requirements of the National Environmental Policy Act (NEPA). 7 figs

  17. FROM PAST TILL TODAY AZERBAIJANIAN MUSIC

    Directory of Open Access Journals (Sweden)

    Hatira Ahmedli CAFER

    2015-09-01

    Full Text Available Ancient Azerbaijanian music was found after archelogical excavations. In the first literature The Book of Dede Korkut, then in Nizami's and Fuzuli's literal works a vast of information could be found about the Medieval Age music. The first phase of Azerbaijanian musical history contains arts of bards, laters phases contains classical modes. The researches of Azerbaijanian modes extend to the Medieval Age. The expand of 19th century European music affected Azerbaijanian culture, too. The early years of 20th century is reckoned as a new rising period in Azerbaijanin music. Uzeyir Hacibeyov composed Leyli and Majnun in that period which was the first opera of the East. Meanwhile, several musical high schools, conservatories, symphony orchestras, national instrumental orchestras, and theatres were established. The smphonic music which was established in 1920's had a major development in between 1940 and 1960. In between 1960 and 1980, younger generation, too, participated in artistic activities, alongside the older generation. In 1988-1994 Armenians invaded Karabagh and commited several genocides which some of the most known are called 20 January and Khojaly genocides. In that period, Azerbaijanian composes divided into three stages as 20 January, Karabagh, and Khojaly. Today, Azerbaijanian music is well known all over the world, while being played in lots of festivals in the whole world.

  18. Introduction: The Continued Importance of Smallholders Today

    Directory of Open Access Journals (Sweden)

    Jacqueline M. Vadjunec

    2016-10-01

    Full Text Available Smallholders remain an important part of human-environment research, particularly in cultural and political ecology, peasant and development studies, and increasingly in land system and sustainability science. This introduction to the edited volume explores land use and livelihood issues among smallholders, in several disciplinary and subfield traditions. Specifically, we provide a short history of smallholder livelihood research in the human-environment tradition. We reflect on why, in an age of rapid globalization, smallholder land use and livelihoods still matter, both for land system science and as a reflection of concerns with inequality and poverty. Key themes that emerge from the papers in this volume include the importance of smallholder farming and land-use practices to questions of environmental sustainability, the dynamic reality of smallholder livelihoods, the challenges of vulnerability and adaptation in contemporary human-environment systems, and the structural and relative nature of the term “smallholder.” Overall these contributions show that smallholder studies are more pertinent than ever, especially in the face of global environmental change. Additionally, we argue that questions of smallholder identity, social difference, and teleconnections provide fertile areas of future research. We conclude that we need to re-envision who the smallholder is today and how this translates into modern human-environment smallholder studies.

  19. Field primatology of today: current ethical issues.

    Science.gov (United States)

    MacKinnon, K C; Riley, E P

    2010-09-01

    As members of professional organizations such as American Society of Primatologists (ASP) and the International Primatological Society (IPS), primatologists must adhere to a set of nonhuman primate-focused principles outlined in resolutions and policy statements on, for example, the ethical treatment of nonhuman primates. Those of us that work in the field must also address issues such as the protection of primate health in the wild and the conservation of wild primate populations. Moreover, we increasingly find ourselves in complex situations where we must balance human and nonhuman primate needs and interests. The selection of commentary pieces in this edition of the American Journal of Primatology originated from presentations given in the symposium, Field Primatology of Today: Navigating the Ethical Landscape, held at the 32nd Annual Meeting of the American Society of Primatologists (ASP) in September 2009. The goals of that symposium and these resulting commentary pieces are threefold: (1) to revive a discussion of key contemporary ethical issues faced by field primatologists, (2) to highlight the need for centrally placed ethical considerations in various facets of our professional lives, particularly research and teaching, and (3) to consider what a comprehensive ethical code that addresses all of these issues might look like. (c) 2010 Wiley-Liss, Inc.

  20. Augmented Reality in Sports: Today and Tomorrow

    Directory of Open Access Journals (Sweden)

    Zafer BOZYER

    2015-08-01

    Full Text Available The rapid change experienced in the field of Information Technologies makes the informati cs more tangible in daily life. Today, it became possible to encounter with the informatics applications almost all the disciplines. As a matter of course, many informatics applications are put into the practice regarding the sports discipline. Because of the condition that the power of information processing has increased and the studies on wearable technol ogies in addition to the expert system design, augmented reality (AR has become a topic which gains imp ortance in the field of sports. There are many studies that are conducted with the aim of increasing the efficiency of physical activities done in many sports branches, ensuring a more fair management of competitions and providing the opportunity for spectators to watch the competitions in a more comfortable and efficient way. In this study; the information about the current augmented reality practices th at are used in various sports branches has been given and the mobile and interactive augmented reality practices which are possible to be seen in future have been mentioned. In addition, there is an augmented reality practice which is designed with the aim of ensuring that the shoots of sports people who are interested in archery, are more stable and of ensuring that the trainings and exercises are more efficient by stating to the sports people whether he or she is in the right position for shoot which is c alled as T shape seen at the time of releasing the arrow.

  1. Academic dishonesty today, unethical practices tomorrow?

    Science.gov (United States)

    LaDuke, Rebekah D

    2013-01-01

    The purpose of this article was to review the most current published literature on the topics of academic dishonesty, unethical professional practices, and research that studied the correlation between these 2 areas of interest. Literature was retrieved by utilizing key words such as academic dishonesty, cheating, workplace dishonesty, and unethical behavior. Multiple research databases were used and a reference librarian in locating relevant research studies resulting in 16 research articles reviewed and 7 articles referenced within the literature review. Upon completion, it became apparent that nursing educators should be concerned that nursing students found to be academically dishonest today may have a higher incidence of displaying unethical practices as a registered nurse tomorrow. It also became clear that the nursing profession needs to conduct its own research in this field to verify findings discovered by other professions such as engineering, business, and psychology. Finally, recommendations were given on how nursing educators should handle the topic of ethics in nursing programs. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. [Poliomyelitis in Landsteiner's time and today].

    Science.gov (United States)

    Schwick, H G

    1991-01-01

    At a meeting of the Royal and Imperial Association of Physicians in Vienna on December 18, 1908 Dr. Karl Landsteiner reported on the successful experimental transmission of poliomyelitis from man to ape in a study which he undertook together with Erwin Popper. In a scientific article that was published shortly after the meeting, Landsteiner wrote that "the poliomyelitis virus belongs to the group of filterable micro-organisms". Soon, Landsteiner's results were confirmed by other colleagues. During a congress in Washington 1912 Landsteiner declared that the development of a vaccine against poliomyelitis might prove difficult but was certainly possible in his opinion. It took another 45 years before the first polio vaccine was available (1955 Salk) and another 5 years until the oral vaccine (1960 Sabin) was implemented. The incidence of poliomyelitis decreased dramatically in industrial countries as a result of vaccination. Today, poliomyelitis is still an enormous threat in developing countries. Together with many national and international institutions the WHO fights this situation very hard by means of vaccination campaigns. The incidence of side effects and insufficient reactions is small with both vaccines. New techniques in the field of molecular biology and a good knowledge of the poliovirus make it likely that further improvements on the vaccines which are currently available will take place.

  3. A review of surgical methods (excluding hair transplantation and their role in hair loss management today

    Directory of Open Access Journals (Sweden)

    Sandeep S Sattur

    2011-01-01

    Full Text Available There is more than one way to manage hair loss surgically. Apart from hair transplantation, there are other techniques which have been used by many to treat baldness. This article attempts to review the surgical methodology and philosophy that have acted as guiding lights in the approach to surgical treatment of baldness over the years and reviews the current role of other techniques in the armamentarium of hair restoration surgeons today.

  4. The transition of new technology to solve today`s problems

    Energy Technology Data Exchange (ETDEWEB)

    Kamin, R.A. [Naval Air Warfare Center, Trenton, NJ (United States); Martin, C.J.; Turner, L.M. [Defense Fuel Supply Center, Alexandria, VA (United States)

    1995-05-01

    Extensive research has been conducted in the development of methods to predict the degradation of F-44 in storage. The Low Pressure Reactor (LPR) has greatly enhanced the stability prediction capabilities necessary to make informed decisions concerning aviation fuel in storage. This technique has in the past been primarily used for research purposes. The Naval Air Warfare Center, Aircraft Division, Trenton, NJ, has used this technique successfully to assist the Defense Fuel Supply Center, Cameron Station, Alexandria, VA, in stability assessments of F-44. The High Performance Liquid Chromatography/Electrochemical Detector (HPLC/EC) antioxidant determination technique has also aided in making stability predictions by establishing the amount of inhibitor currently in the product. This paper will address two case studies in which the above new technology was used to insure the rapid detection and diagnosis of today`s field and logistic problems.

  5. ACTS 2014

    DEFF Research Database (Denmark)

    Co-curator of ACTS 2014 together with Rasmus Holmboe, Judith Schwarzbart and Sanne Kofoed. ACTS is the Museum of Contemporary Art’s international bi-annual festival. ACTS was established in 2011 and, while the primary focus is on sound and performance art, it also looks toward socially oriented art....... For the 2014 festival, the museum has entered into a collaboration with the Department for Performance Design at Roskilde University – with continued focus on sound and performance art, and social art in public spaces. With ACTS, art moves out of its usual exhibition space and instead utilizes the city, its...... various possibilities and public spaces as a stage. ACTS takes place in and around the museum and diverse locations in Roskilde city. ACTS is partly curated by the museum staff and partly by guest curators. ACTS 2014 is supported by Nordea-fonden and is a part of the project The Museum goes downtown....

  6. Fixing health care from the inside, today.

    Science.gov (United States)

    Spear, Steven J

    2005-09-01

    Today, you are about as safe in a U.S. hospital as you would be parachuting off a bridge or a building. But it doesn't have to be that way. Right now, some hospitals are making enormous short-term improvements, with no legislation or market reconfiguration and little or no capital investment. Instead of waiting for sweeping changes in market mechanisms, these institutions are taking an operations approach to patient care. In case after detailed case, the article describes how doctors, nurses, technicians, and managers are radically increasing the effectiveness of patient care and dramatically lowering its cost by applying the same capabilities in operations design and improvement that drive the famous Toyota Production System. They are removing ambiguity in the output, responsibilities, connections, and methods of their work processes. These changes-which can be done in the course of an ordinary workday, sometimes in a matter of hours-are designed to make the following crystal clear: Which patient gets which procedure (output); Who does which aspect of the job (responsibility); Exactly which signals are used to indicate that the work should begin (connection); and Precisely how each step is carried out (method). Equally important, managers are being transformed from rescuers who arrive with ready-made solutions into problem solvers who help colleagues learn the experimental method. Thus, these hospitals are breaking free of the work-around culture that routinely obscures the root causes of so many problems, creates so much waste, and leads to so many unnecessary deaths.

  7. Ancient water supports today's energy needs

    Science.gov (United States)

    D'Odorico, Paolo; Natyzak, Jennifer L.; Castner, Elizabeth A.; Davis, Kyle F.; Emery, Kyle A.; Gephart, Jessica A.; Leach, Allison M.; Pace, Michael L.; Galloway, James N.

    2017-05-01

    The water footprint for fossil fuels typically accounts for water utilized in mining and fuel processing, whereas the water footprint of biofuels assesses the agricultural water used by crops through their lifetime. Fossil fuels have an additional water footprint that is not easily accounted for: ancient water that was used by plants millions of years ago, before they were transformed into fossil fuel. How much water is mankind using from the past to sustain current energy needs? We evaluate the link between ancient water virtually embodied in fossil fuels to current global energy demands by determining the water demand required to replace fossil fuels with biomass produced with water from the present. Using equal energy units of wood, bioethanol, and biodiesel to replace coal, natural gas, and crude oil, respectively, the resulting water demand is 7.39 × 1013 m3 y-1, approximately the same as the total annual evaporation from all land masses and transpiration from all terrestrial vegetation. Thus, there are strong hydrologic constraints to a reliance on biofuel energy produced with water from the present because the conversion from fossil fuels to biofuels would have a disproportionate and unsustainable impact on the modern water. By using fossil fuels to meet today's energy needs, we are virtually using water from a geological past. The water cycle is insufficient to sustain the production of the fuel presently consumed by human societies. Thus, non-fuel-based renewable energy sources are needed to decrease mankind's reliance on fossil fuel energy without placing an overwhelming pressure on global freshwater resources.

  8. "What Today's University Students Have Taught Us”

    Directory of Open Access Journals (Sweden)

    Alison J. Head

    2016-12-01

    Full Text Available Today, more students in the US are attending university than ever before. An unprecedented number of these students were born digital—meaning digital technologies have been a constant feature in their lives. For these young adults, information literacy competencies are always being formed, practiced, and learned. Project Information Literacy (PIL is a series of ongoing quantitative and qualitative research studies in the US that investigates what it is like to be a university student in the digital age. This research study has investigated how students find information and conduct research—in their words and through their experiences—for coursework, use in their everyday lives, and, once they graduate, in the workplace and their communities. Since 2008, more than 11,000 university students at nearly 60 US higher education institutions have been surveyed or interviewed, making PIL the largest study of information literacy ever conducted. Results from PIL’s studies have concluded students’ information competencies are put to the test in the vast information landscape they inhabit. Furthermore, finding and using information is exponentially more complex than it was a generation ago, especially since the information landscape has shifted from one of scarce resources to one of overload. In this keynote, five research takeaways were presented from PIL’s eight studies: (1 Students find research more difficult than ever before, (2 getting started is the hardest part of research, (3 frustrations begin with finding context, i.e., big picture, information-gathering, language, and situational context, (4 search strategies are based on predictability, familiarity, and efficiency, and (5 evaluation is the one information skills most learn to use. Discussion included implications of these findings for teaching, learning, work, and librarianship in the 21st century.

  9. Effect of two additional interventions, test and reflection, added to standard cardiopulmonary resuscitation training on seventh grade students' practical skills and willingness to act: a cluster randomised trial.

    Science.gov (United States)

    Nord, Anette; Hult, Håkan; Kreitz-Sandberg, Susanne; Herlitz, Johan; Svensson, Leif; Nilsson, Lennart

    2017-06-23

    The aim of this research is to investigate if two additional interventions, test and reflection, after standard cardiopulmonary resuscitation (CPR) training facilitate learning by comparing 13-year-old students' practical skills and willingness to act. Seventh grade students in council schools of two municipalities in south-east Sweden. School classes were randomised to CPR training only (O), CPR training with a practical test including feedback (T) or CPR training with reflection and a practical test including feedback (RT). Measures of practical skills and willingness to act in a potential life-threatening situation were studied directly after training and at 6 months using a digital reporting system and a survey. A modified Cardiff test was used to register the practical skills, where scores in each of 12 items resulted in a total score of 12-48 points. The study was conducted in accordance with current European Resuscitation Council guidelines during December 2013 to October 2014. 29 classes for a total of 587 seventh grade students were included in the study. The total score of the modified Cardiff test at 6 months was the primary outcome. Secondary outcomes were the total score directly after training, the 12 individual items of the modified Cardiff test and willingness to act. At 6 months, the T and O groups scored 32 (3.9) and 30 (4.0) points, respectively (ptraining improved the students' acquisition of practical CPR skills. Reflection did not increase further CPR skills. At 6-month follow-up, no intervention effect was found regarding willingness to make a life-saving effort. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  10. Adding fast‐acting insulin aspart to basal insulin significantly improved glycaemic control in patients with type 2 diabetes: A randomized, 18‐week, open‐label, phase 3 trial (onset 3)

    OpenAIRE

    Rodbard, Helena W.; Tripathy, Devjit; Vidrio Velázquez, Maricela; Demissie, Marek; Tamer, Søren C.; Piletič, Milivoj

    2017-01-01

    Aim To confirm glycaemic control superiority of mealtime fast‐acting insulin aspart (faster aspart) in a basal–bolus (BB) regimen vs basal‐only insulin. Materials and methods In this open‐label, randomized, 18‐week trial (51 sites; 6 countries), adults (n = 236) with inadequately controlled type 2 diabetes (T2D; mean glycosylated haemoglobin [HbA1c] ± SD: 7.9% ± 0.7% [63.1 ± 7.5 mmol/mol]) receiving basal insulin and oral antidiabetic drugs underwent 8‐week optimization of prior once‐daily ba...

  11. iACT-CEL: A Feasibility Trial of a Face-to-Face and Internet-Based Acceptance and Commitment Therapy Intervention for Chronic Pain in Singapore

    Directory of Open Access Journals (Sweden)

    Su-Yin Yang

    2017-01-01

    Full Text Available Psychological interventions are increasingly utilising online or mobile phone based platforms to deliver treatment, including that for people with chronic pain. The aims of this study were to develop an adapted form of Acceptance and Commitment Therapy (ACT for chronic pain in Singapore and to test the feasibility of elements of this treatment delivered via the internet and email. Methods. Thirty-three participants recruited from a tertiary pain management clinic and via the clinic website participated in this program over a period of five weeks with a 3-month follow-up. Treatment outcomes were assessed at three assessment time points. Results. 90.9% of participants completed the program, with 81.8% reporting high treatment satisfaction. Significant changes in depression, t=3.08, p=0.002 (baseline to posttreatment, t=3.28, p=0.001 (baseline to follow-up, and pain intensity, t=2.15, p=0.03 (baseline to follow-up were found. Mainly small effect sizes (d=0.09–0.39 with a moderate effect size (d=0.51 for depression were found at posttreatment. Clinically meaningful improvement in at least one outcome was demonstrated in 75.8% of participants. Conclusions. An adaptation of ACT for people with chronic pain in Singapore appears promising. Optimal treatment design and more effective ways to target outcomes and processes measured here are required.

  12. The effectiveness of physical activity monitoring and distance counseling in an occupational setting – Results from a randomized controlled trial (CoAct

    Directory of Open Access Journals (Sweden)

    Reijonsaari Karita

    2012-05-01

    Full Text Available Abstract Background Lack of physical activity (PA is a known risk factor for many health conditions. The workplace is a setting often used to promote activity and health. We investigated the effectiveness of an intervention on PA and productivity-related outcomes in an occupational setting. Methods We conducted a randomized controlled trial of 12 months duration with two 1:1 allocated parallel groups of insurance company employees. Eligibility criteria included permanent employment and absence of any condition that risked the participant’s health during PA. Subjects in the intervention group monitored their daily PA with an accelerometer, set goals, had access to an online service to help them track their activity levels, and received counseling via telephone or web messages for 12 months. The control group received the results of a fitness test and an information leaflet on PA at the beginning of the study. The intervention’s aim was to increase PA, improve work productivity, and decrease sickness absence. Primary outcomes were PA (measured as MET minutes per week, work productivity (quantity and quality of work; QQ index, and sickness absence (SA days at 12 months. Participants were assigned to groups using block randomization with a computer-generated scheme. The study was not blinded. Results There were 544 randomized participants, of which 521 were included in the analysis (64% female, mean age 43 years. At 12 months, there was no significant difference in physical activity levels between the intervention group (n = 264 and the control group (n = 257. The adjusted mean difference was −206 MET min/week [95% Bayesian credible interval −540 to 128; negative values favor control group]. There was also no significant difference in the QQ index (−0.5 [−4.4 to 3.3] or SA days (0.0 [−1.2 to 0.9]. Of secondary outcomes, body weight (0.5 kg [0.0 to 1.0] and percentage of body fat (0.6% [0.2% to 1.1%] were slightly

  13. DOW AGROSCIENCES TODAY AND NEW REVOLUTIONARY SOLUTIONS

    Directory of Open Access Journals (Sweden)

    Slavko Vujević

    2008-09-01

    Full Text Available Dow AgroSciences LLC, based in Indianapolis, Indiana, USA, is a top tier agricultural company providing innovative crop protection, pest and vegetation management, seed, and agricultural biotechnology solutions to serve the world's growing population. Global sales for Dow AgroSciences, a wholly owned subsidiary of The Dow Chemical Company, are $3.8 billion. The company's roots in the agricultural marketplace date back to 1950 as the agricultural unit of The Dow Chemical Company and as part of Eli Lilly and Company's agricultural business. In 1989, the DowElanco joint venture was formed, and the company continued to develop new products and acquire strategic businesses. DowElanco acquired majority ownership in Mycogen Seeds in 1996; in 1997, The Dow Chemical Company acquired 100 percent of DowElanco and the company was renamed Dow AgroSciences. Other significant acquisitions include acetochlor herbicide, Cargill Hybrid Seeds, several Brazilian seed companies and the agricultural chemicals business of Rohm and Haas. Dow AgroSciences is positioned for the future through focused implementation of its strategy which revolves around productivity, portfolio management and innovation. This focus allows the company to grow through an ambitious innovation program that maximizes the products being sold today and creates new, revolutionary solutions that will surprise customers in the future. D Dow AgroSciences is committed to sustainable chemistry and has a competitive advantage in our natural products discovery capability. We've won a prestigious award for technical innovation incorporating "green" chemistry principles into chemical design, manufacture and use. Dow AgroSciences offers a full range of seeds for corn, sunflowers, canola, cotton, soybeans and alfalfa. In addition, we have developed seeds specifically bred for nutritional quality. Dow AgroSciences uses conventional breeding techniques and tools of biotechnology to produce oils that are low in

  14. Radioactive waste today - an asset tomorrow

    Energy Technology Data Exchange (ETDEWEB)

    Holmstrand, M. [Norwegian Radiation Protection Authority (Norway)

    2014-07-01

    possibility that extracted thorium could be stored in the form of thorium oxide and later used as fuel in nuclear power plants. If this is feasible, then today's radioactive waste could be tomorrow's asset. Document available in abstract form only. (authors)

  15. Preventing recurrence of endometriosis by means of long-acting progestogen therapy (PRE-EMPT): report of an internal pilot, multi-arm, randomised controlled trial incorporating flexible entry design and adaption of design based on feasibility of recruitment.

    Science.gov (United States)

    Middleton, Lee J; Daniels, Jane P; Weckesser, Annalise; Bhattacharya, Siladitya

    2017-03-11

    Endometriosis is associated with the growth of endometrium in ectopic sites mainly within the pelvis. This results in inflammation and scarring, causing pain and impaired quality of life. Endometriotic lesions can be excised or ablated surgically, but the risk of recurrence is high. A Heath Technology Assessment commissioning call in 2011 sought applications for trials aimed at evaluating long-term effectiveness of postoperative, long-acting, reversible contraceptives (LARCs) in preventing recurrence of endometriosis. A survey of gynaecologists indicated that there was no consensus about which LARC (Levonorgestrel Intrauterine System (LNG-IUS) or depot medroxyprogesterone acetate injection (DMPA)) or comparator (combined oral contraceptive pill (COCP) or no treatment) should be evaluated. Hence, we designed a 'flexible-entry' internal pilot to assess whether a four-arm trial was feasible including a possible design adaption based on pilot findings. In this pilot, women could be randomised to two, three or four treatment options provided that one was a LARC and one was a non-LARC. An assessment of feasibility based on recruitment to these options and a revised substantive trial design was considered by an independent oversight committee. The study ran for 1 year from April 2014 and 77 women were randomised. Only 5 (6%) women accepted randomisation to all groups, with 63 (82%) having a LARC preference and 55 (71%) a non-LARC preference. Four-way and three-way designs were ruled out with a two-way LARC versus COCP design, stratified by prerandomisation choice of LARC and optional subrandomisation to LNG-IUS versus DMPA considered a feasible substantive study. Multi-arm studies are potentially efficient as they can answer multiple questions simultaneously but are difficult to recruit to if there are strong patient or clinician preferences. A flexible approach to randomisation in a pilot phase can be used to assess feasibility of such studies and modify a trial design

  16. What are today's priorities in research?

    Science.gov (United States)

    1994-01-01

    The World Health Organization (WHO) Global Programme on AIDS has identified priority areas of HIV/AIDS-related research. Vaccine trials are need to evaluate their effectiveness and their accessibility and availability (supply and price) to developing countries with the greatest need. The pharmaceutical industry and national governments should work to develop microbicidal agents for use in the vagina. Research on the care of people with AIDS is needed to document the best way to provide their care in developing countries and to improve their quality of life. Another research priority is the resurgence of tuberculosis (TB): its association with HIV infection, and management of TB in areas where the HIV prevalence is high. WHO would like to see research establishing simplified case management regimes for the control and management of sexually transmitted diseases (STDs), STD case management that can be integrated into primary health care systems or at the primary health care level, simple and inexpensive diagnostic tests (particularly for women, who often are asymptomatic), and integration of STD management into family planning programs. More research needs to conducted on the availability and use of female condoms, so women can enhance their capability of protecting themselves. WHO would like more HIV/AIDS-related behavior research in the following areas: descriptive research, economic impact, community support, women's empowerment, and behavior change. HIV/AIDS-related researchers should ask themselves 3 fundamental questions: Does it work? What is the best way to do it? What does it cost?

  17. Human Tumor Antigens Yesterday, Today, and Tomorrow.

    Science.gov (United States)

    Finn, Olivera J

    2017-05-01

    The question of whether human tumors express antigens that can be recognized by the immune system has been answered with a resounding YES. Most were identified through spontaneous antitumor humoral and cellular immune responses found in cancer patients and include peptides, glycopeptides, phosphopeptides, viral peptides, and peptides resulting from common mutations in oncogenes and tumor-suppressor genes, or common gene fusion events. Many have been extensively tested as candidates for anticancer vaccines. More recently, attention has been focused on the potentially large number of unique tumor antigens, mutated neoantigens, that are the predicted products of the numerous mutations revealed by exome sequencing of primary tumors. Only a few have been confirmed as targets of spontaneous immunity and immunosurveillance, and even fewer have been tested in preclinical and clinical settings. The field has been divided for a long time on the relative importance of shared versus mutated antigens in tumor surveillance and as candidates for vaccines. This question will eventually need to be answered in a head to head comparison in well-designed clinical trials. One advantage that shared antigens have over mutated antigens is their potential to be used in vaccines for primary cancer prevention. Cancer Immunol Res; 5(5); 347-54. ©2017 AACR . ©2017 American Association for Cancer Research.

  18. Curatorial Acts

    NARCIS (Netherlands)

    Bal, M.

    2012-01-01

    In a self-critical inquiry into my own recent work of co-curating and the experience of seeing my video work being curated by others, this article examines acts of framing as performative acts that seek to transform visitors' preconceptions. This affective effect is pursued by means of immersion,

  19. Phase II trial in China of a new, rapidly-acting and effective oral antimalarial, CGP 56697, for the treatment of Plasmodium falciparum malaria.

    Science.gov (United States)

    Jiao, X; Liu, G Y; Shan, C O; Zhao, X; Li, X W; Gathmann, I; Royce, C

    1997-09-01

    One hundred and two Chinese out-patients with naturally acquired, previously untreated, falciparum malaria were selected to evaluate the efficacy of a new combination anti-malaria therapy, CGP 56697 (artemether plus benflumetol). In this open non-comparative trial each patient received a combination of 80 mg artemether and 480 mg benflumetol given orally at 0, 8, 24 and 48 hours (total: 320 mg artemether, 1,920 mg benflumetol). Patients were kept for 28 days in a transmission-free hospital in an area with chloroquine resistant falciparum malaria to prevent reinfection and to aid diagnosis of recrudescence. Progress and possible adverse effects were monitored by blood film parasitology, blood biochemistry assays, urinalysis, ECG and X-ray. Ninety-eight of the 102 patients were shown to be free of infection at 28 days, a 96.1% cure rate. Parasite reduction at 24 hours was 99.4%. Time to effect complete parasite clearance ranged from 24 to 54 hours (median 30 hours). Time for fever clearance ranged from 6 to 78 hours (median 18 hours). Recrudescence was low (3.9%). No significant adverse side-effects were encountered. It is concluded that CGP 56697, a combination anti-malaria therapy of artemether with benflumetol, offered a rapid and highly effective treatment for acute uncomplicated falciparum malaria in an area of chloroquine-resistant malaria in China.

  20. Deterrence Today Roles, Challenges and Responses

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, L.A.

    2007-07-01

    deterrence in reassuring traditional allies confronting new hostile proliferators. In practice, however, extending deterrence in response to proliferation threats raises a number of difficult questions and will require adaptation of traditional approaches. But in other situations, what role, if any, deterrence - though not necessarily nuclear deterrence - should play is itself an open question. This applies perhaps most to possible efforts by the United States and other countries to bring to bear deterrence or other complementary strategies aimed at shaping a terrorist adversary's strategic calculus to help meet the threat of use of a nuclear weapon or other WMD attack by al- Qaeda and its Jihadist allies. Here, too, new thinking will be required to define and implement such complementary strategies for influencing the calculations of terrorist adversaries. But questions about the applicability - or at least complexities - of deterrence also are reflected in today's expressions of concern that some new nuclear powers may be 'non-deterrable' as well as that an asymmetric balance of stakes is creating a new deterrence equation outside of Europe. Regarding Russia, Moscow no longer is an adversary of the West but nor is it a friend - and moving beyond deterrence to a non-adversarial relationship so far has been more rhetoric than reality. As for China, the U.S. extended nuclear deterrent continues to play a role in helping to avoid a confrontation over Taiwan as well as in reassuring those officials in Asia that are uncertain about the ultimate impact of China's rise. That said, it would be preferable to mute the role of nuclear deterrence in the U.S.-China strategic relationship and, as with Russia, to develop a non-adversarial relationship between the United States and China. From an American perspective, the following essay addresses this new, more complex agenda of the early 21. century. Specifically, it turns first to the challenge of extending

  1. Deterrence Today Roles, Challenges and Responses

    International Nuclear Information System (INIS)

    Dunn, L.A.

    2007-01-01

    deterrence in reassuring traditional allies confronting new hostile proliferators. In practice, however, extending deterrence in response to proliferation threats raises a number of difficult questions and will require adaptation of traditional approaches. But in other situations, what role, if any, deterrence - though not necessarily nuclear deterrence - should play is itself an open question. This applies perhaps most to possible efforts by the United States and other countries to bring to bear deterrence or other complementary strategies aimed at shaping a terrorist adversary's strategic calculus to help meet the threat of use of a nuclear weapon or other WMD attack by al- Qaeda and its Jihadist allies. Here, too, new thinking will be required to define and implement such complementary strategies for influencing the calculations of terrorist adversaries. But questions about the applicability - or at least complexities - of deterrence also are reflected in today's expressions of concern that some new nuclear powers may be 'non-deterrable' as well as that an asymmetric balance of stakes is creating a new deterrence equation outside of Europe. Regarding Russia, Moscow no longer is an adversary of the West but nor is it a friend - and moving beyond deterrence to a non-adversarial relationship so far has been more rhetoric than reality. As for China, the U.S. extended nuclear deterrent continues to play a role in helping to avoid a confrontation over Taiwan as well as in reassuring those officials in Asia that are uncertain about the ultimate impact of China's rise. That said, it would be preferable to mute the role of nuclear deterrence in the U.S.-China strategic relationship and, as with Russia, to develop a non-adversarial relationship between the United States and China. From an American perspective, the following essay addresses this new, more complex agenda of the early 21. century. Specifically, it turns first to the challenge of extending deterrence to U.S. allies and

  2. The road, the bridge, the square, the tower: the act of being a social educator today

    Directory of Open Access Journals (Sweden)

    Luigi Ciotti

    2010-07-01

    Full Text Available Beginning with an overview of the current cultural, social and ethical climate in which a social educator operates, Luigi Ciotti underlines the importance of healthy realism, accompanied with passion in order to face the difficulties and risks involved in social and educational work. He emphasised the importance of constantly renewing motivation and courage in order to continue to build hope when dealing with peoples needs. Concrete examples of real life experiences that have marked the life of Luigi Ciotti emerge from this from this discussion with Professoressa Spetltini reinforcing the idea of feeling of never arriving at a destination but always being ready to listen.

  3. Leadership succession in nursing: thinking and acting today to ensure a better tomorrow

    OpenAIRE

    Denize Bouttelet Munari; Ana Lúcia Queiroz Bezerra; Alyne Leite Nogueira; Bárbara Souza Rocha; Elyana Teixeira Sousa; Luana Cássia Miranda Ribeiro

    2017-01-01

    The world has been experiencing a crisis in leadership that has evolved with the ageing of a generation that pioneered the innovation and transformation of collective life(1). Changes have been introduced by the younger generations, and with their new habits, values and behaviors, they have begun taking the reigns of the management or are in the front lines of organizations. However, changes do not occur merely through the presence of what is new; previous generations are still essential to a...

  4. The America COMPETES Act and the FY2009 Budget

    National Research Council Canada - National Science Library

    Stine, Deborah D

    2008-01-01

    The America COMPETES Act (P.L. 110-69) responds to concerns that the United States may not be able to compete economically with other nations in the future due to insufficient investment today in science and technology research...

  5. 75 FR 68788 - Sunshine Act; Notice of Meeting

    Science.gov (United States)

    2010-11-09

    ... Problem of Age Discrimination in Today's Economic Times. Note: In accordance with the Sunshine Act, the... information on these meetings. The EEOC provides sign language interpretation and Communication Access...

  6. America COMPETES Act: Programs, Funding, and Selected Issues

    National Research Council Canada - National Science Library

    Stine, Deborah D

    2008-01-01

    .... The act responds to concerns that the United States may not be able to compete economically with other nations in the future due to insufficient investment today in science and technology research...

  7. "Mind the gap"--the impact of variations in the duration of the treatment gap and overall treatment time in the first UK Anal Cancer Trial (ACT I).

    Science.gov (United States)

    Glynne-Jones, Rob; Sebag-Montefiore, David; Adams, Richard; McDonald, Alec; Gollins, Simon; James, Roger; Northover, John M A; Meadows, Helen M; Jitlal, Mark

    2011-12-01

    The United Kingdom Coordinating Committee on Cancer Research anal cancer trial demonstrated the benefit of combined modality treatment (CMT) using radiotherapy (RT), infusional 5-fluorouracil, and mitomycin C over RT alone. The present study retrospectively examines the impact of the recommended 6-week treatment gap and local RT boost on long-term outcome. A total of 577 patients were randomly assigned RT alone or CMT. After a 6-week gap responders received a boost using either additional external beam radiotherapy (EBRT) (15 Gy) or iridium-192 implant (25 Gy). The effect of boost, the gap between initial treatment (RT alone or CMT) and boost (Tgap), and overall treatment time (OTT) were examined for their impact on outcome. Among the 490 good responders, 436 (89%) patients received a boost after initial treatment. For boosted patients, the risk of anal cancer death decreased by 38% (hazard ratio [HR]: 0.62, 99% CI 0.35-1.12; p=0.04), but there was no evidence this was mediated via a reduction in locoregional failure (LRF) (HR: 0.90, 99% CI 0.48-1.68; p=0.66). The difference in Tgap was only 1.4 days longer for EBRT boost, compared with implant (p=0.51). OTT was longer by 6.1 days for EBRT (p=0.006). Tgap and OTT were not associated with LRF. Radionecrosis was reported in 8% of boosted, compared with 0% in unboosted patients (p=0.03). These results question the benefit of a radiotherapy boost after a 6-week gap. The higher doses of a boost may contribute more to an increased risk of late morbidity, rather than local control. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte Oncology Network

    International Nuclear Information System (INIS)

    Brizzi, Maria P; Ferretti, Benedetta; Alabiso, Oscar; Ciuffreda, Libero; Bertetto, Oscar; Papotti, Mauro; Dogliotti, Luigi; Berruti, Alfredo; Ferrero, Anna; Milanesi, Enrica; Volante, Marco; Castiglione, Federico; Birocco, Nadia; Bombaci, Sebastiano; Perroni, Davide

    2009-01-01

    Well-differentiated neuroendocrine carcinomas are highly vascularized and may be sensitive to drugs administered on a metronomic schedule that has shown antiangiogenic properties. A phase II study was designed to test the activity of protracted 5-fluorouracil (5FU) infusion plus long-acting release (LAR) octreotide in patients with neuroendocrine carcinoma. Twenty-nine patients with metastatic or locally advanced well-differentiated neuroendocrine carcinoma were treated with protracted 5FU intravenous infusion (200 mg/m 2 daily) plus LAR octreotide (20 mg monthly). Patients were followed for toxicity, objective response, symptomatic and biochemical response, time to progression and survival. Assessment by Response Evaluation Criteria in Solid Tumors (RECIST) criteria showed partial response in 7 (24.1%), stable disease in 20 (69.0%), and disease progression in 2 patients. Response did not significantly differ when patients were stratified by primary tumor site and proliferative activity. A biochemical (chromogranin A) response was observed in 12/25 assessable patients (48.0%); symptom relief was obtained in 9/15 symptomatic patients (60.0%). There was non significant decrease in circulating vascular epithelial growth factor (VEGF) over time. Median time to progression was 22.6 months (range, 2.7-68.5); median overall survival was not reached yet. Toxicity was mild and manageable. Continuous/metronomic 5FU infusion plus LAR octreotide is well tolerated and shows activity in patients with well-differentiated neuroendocrine carcinoma. The potential synergism between metronomic chemotherapy and antiangiogenic drugs provides a rationale for exploring this association in the future. NCT00953394

  9. ACT Test

    Science.gov (United States)

    ... to clot, the higher the degree of clotting inhibition. During surgery, the ACT is kept above a ... What is ECLS? An Introduction to Extracorporeal Life Support. University of Michigan Health System [On-line information]. ...

  10. Tumour- and treatment-related colostomy rates following mitomycin C or cisplatin chemoradiation with or without maintenance chemotherapy in squamous cell carcinoma of the anus in the ACT II trial.

    Science.gov (United States)

    Glynne-Jones, R; Kadalayil, L; Meadows, H M; Cunningham, D; Samuel, L; Geh, J I; Lowdell, C; James, R; Beare, S; Begum, R; Ledermann, J A; Sebag-Montefiore, D

    2014-08-01

    Squamous cell carcinoma of the anus (SCCA) is highly sensitive to chemoradiation (CRT) which achieves good loco-regional control and preserves anal function. However, some patients require permanent stoma formation either as a result of surgery on relapse, poor anal function or treatment-related symptoms. Our aim was to determine patient, tumour and treatment-related colostomy rates following CRT and maintenance chemotherapy in the ACT II trial. The ACT II trial recruited 940 patients comparing 5FU-based CRT using cisplatin (CisP) or mitomycin C (MMC) with or without additional maintenance chemotherapy. We investigated the association between colostomy-free survival (CFS) and progression-free survival (PFS) with age, gender, T-stage, N-stage, treatment and baseline haemoglobin. The median follow-up was 5.1 years (n = 884 evaluable/940); tumour site canal (84%), margin (14%); stage T1/T2 (52%), T3/T4 (46%); N+ (32%), N0 (62%). Twenty out of 118 (17%) colostomies fashioned before CRT were reversed within 8 months. One hundred and twelve patients had a post-treatment colostomy due to persistent disease (98) or morbidity (14). Fifty-two per cent (61/118) of all pre-treatment colostomies were never reversed. The 5-year CFS rates were 68% MMC/Maint, 70% CisP/Maint, 68% MMC/No-maint and 65% CisP/No-maint. CRT with CisP did not improve CFS when compared with MMC (hazard ratio: 1.04, 95% confidence interval: 0.82-1.31, P = 0.74). The 5-year CFS rates were higher for T1/T2 (79%) than T3/T4 (54%) tumours and higher for node-negative (72%) than node-positive (60%) patients. Significant predictors of CFS were gender, T-stage and haemoglobin, while treatment factors had no impact on outcome. Similar associations were found between PFS and tumour/treatment-related factors. The majority (52%) of pre-treatment colostomies were never reversed. Neither CRT with 5FU/CisP nor maintenance chemotherapy impacted on CFS. The low risk of colostomy for late effects (1.7%) is likely to be

  11. Efficacy, tolerability, and safety of aripiprazole once-monthly versus other long-acting injectable antipsychotic therapies in the maintenance treatment of schizophrenia: a mixed treatment comparison of double-blind randomized clinical trials.

    Science.gov (United States)

    Majer, Istvan M; Gaughran, Fiona; Sapin, Christophe; Beillat, Maud; Treur, Maarten

    2015-01-01

    Treatment with long-acting injectable (LAI) antipsychotic medication is an important element of relapse prevention in schizophrenia. Recently, the intramuscular once-monthly formulation of aripiprazole received marketing approval in Europe and the United States for schizophrenia. This study aimed to compare aripiprazole once-monthly with other LAI antipsychotics in terms of efficacy, tolerability, and safety. A systematic literature review was conducted to identify relevant double-blind randomized clinical trials of LAIs conducted in the maintenance treatment of schizophrenia. MEDLINE, MEDLINE In-Process, Embase, the Cochrane Library, PsycINFO, conference proceedings, clinical trial registries, and the reference lists of key review articles were searched. The literature search covered studies dating from January 2002 to May 2013. Studies were required to have ≥24 weeks of follow-up. Patients had to be stable at randomization. Studies were not eligible for inclusion if efficacy of acute and maintenance phase treatment was not reported separately. Six trials were identified (0.5% of initially identified studies), allowing comparisons of aripiprazole once-monthly, risperidone LAI, paliperidone palmitate, olanzapine pamoate, haloperidol depot, and placebo. Data extracted included study details, study duration, the total number of patients in each treatment arm, efficacy, tolerability, and safety outcomes. The efficacy outcome contained the number of patients that experienced a relapse, tolerability outcomes included the number of patients that discontinued treatment due to treatment-related adverse events (AEs), and that discontinued treatment due to reasons other than AEs (e.g., loss to follow-up). Safety outcomes included the incidence of clinically relevant weight gain and extrapyramidal symptoms. Data were analyzed by applying a mixed treatment comparison competing risks model (efficacy) and using binary models (safety). There was no statistically significant

  12. Mechanical vapor compression refrigeration for low temperature industrial applications today

    International Nuclear Information System (INIS)

    Ferguson, J.E.

    1987-01-01

    If the super conductor industry settles out at a temperature of -100 0 F or above, mechanical refrigeration will be vying for the cooling business. Today there very definitely is a break point in the application of equipment at approximately -120 0 F or 189 0 K. Other technologies are generally utilized below this level. However, with market potential comes invention and breakthroughs in refrigeration can also occur. Today standard refrigeration systems are cost effective, reliable and produced in the millions for high temperature applications of +10 0 F to +40 0 F evaporator temperature. Lower temperatures require additional hardware, consume additional power and are produced today in limited quantities for special applications

  13. A Proof-of-Concept Clinical Trial of A Single Luteal Use of Long-Acting Gonadotropin-Releasing Hormone Antagonist Degarelix in Controlled Ovarian Stimulation for In Vitro Fertilization: Long Antagonist Protocol

    Directory of Open Access Journals (Sweden)

    Evangelos G. Papanikolaou

    2018-03-01

    Full Text Available IntroductionA drawback of gonadotropin-releasing hormone (GnRH antagonist protocols in in vitro fertilization (IVF is that they have limited flexibility in cycle programming. This proof of concept study explored the efficacy of a single-dose, long-acting GnRH antagonist IVF protocol. Trial registration number is NCT03240159, retrospectively registered on March 08, 2017.Materials and methodsThe efficacy of a single-dose long-acting antagonist, degarelix, was explored initially in healthy donors and subsequently in infertile patients. In the first part, five healthy oocyte donors underwent ovarian stimulation with this new protocol: in the late luteal phase, at day 24, a bolus injection of degarelix was administered subcutaneously to control the LH surge in the follicular phase. Ovarian stimulation with gonadotropins was initiated subsequently from day 7 to day 10. End points were first to inhibit the LH surge later in the follicular phase and, second, to retrieve mature oocytes for IVF. In the second part, five infertile women received the same bolus injection of degarelix administered during the luteal phase at day 24. Different gonadotropin starting days (day 2 through day 8 were tested in order to observe possible differences in ovarian stimulation. In these infertile patients, fresh embryo transfers were performed to assess the pregnancy efficacy of this protocol on pregnancy outcomes and to address any possible negative effects on endometrium receptivity.ResultsIn the first part of the study, all donors were effectively downregulated with a single luteal dose of 0.5 ml of degarelix for up to 22 days until the final oocyte maturation triggering day. Mature oocytes were retrieved after 36 h from all patients and all produced 2–7 blastocysts. In the second part, all five infertile patients achieved sufficient LH downregulation and completed ovarian stimulation without any LH surge. All patients (except one with freeze all strategy had

  14. Sustainable development of the today accommodation; Developpement durable de l'habitat existant

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This first colloquium deals with the energy mastership and the greenhouse gases reduction in the today accommodation. The accommodation represent u=indeed the main part of the energy consumption in front of the industry, the transports, the ternary buildings and the agricultural. This document proposes six papers presented during this day: the importance of the accommodation improvement market; the energy performance of buildings and the main requirements of the french directive; the energy performance of buildings and the german regulations in existing buildings; the energy performance standards in existing buildings in UK; the example of the danish certification; the home energy conservation Act (HECA) in United Kingdom. (A.L.B.)

  15. 78 FR 21981 - Sunshine Act Meeting

    Science.gov (United States)

    2013-04-12

    ... transparency, liquidity, efficiency, or other aspects of the structure of the corporate bond and asset-backed... provisions of the Government in the Sunshine Act, Public Law 94-409, that the Securities and Exchange... focus on the characteristics of the corporate bond and asset-backed securities markets today, how those...

  16. 78 FR 67144 - Sunshine Act Notice

    Science.gov (United States)

    2013-11-08

    ... EQUAL EMPLOYMENT OPPORTUNITY COMMISSION Sunshine Act Notice AGENCY HOLDING THE MEETING: Equal Employment Opportunity Commission. DATE AND TIME: Wednesday, November 13, 2013, 9:30 a.m. Eastern Time. PLACE.... Announcement of Notation Votes, and 2. National Origin Discrimination in Today's Workplace. Note: In accordance...

  17. A double-blind randomised, placebo-controlled trial evaluating the influence of oral long-acting muscle relaxant (Mebeverine MR), and insufflation with CO{sub 2} on pain associated with barium enema

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, A.S.; Chapman, A.H.; Wilson, D.; Culpan, A.G. [Department of Radiology, St. James' s University Hospital, Beckett Street, LS9 7TF, Leeds (United Kingdom)

    2003-07-01

    Previous investigators have shown significant benefit using CO{sub 2} for bowel insufflation. Others have suggested that the long-acting smooth muscle relaxant, Mebeverine, may be of benefit. We subjected this to a randomised double-blind trial. A total of 181 outpatients were randomised to receive either Mebeverine or placebo as pre-medication, and either air or CO{sub 2} for bowel insufflation, thus creating four treatment groups. Visual-analogue lines were used to record pain scores before, during, and up to 8 h following the enema. All groups showed increased pain scores during the enema, with peak pain scores at the end of the examination, falling to baseline scores by 8 h. Patients receiving the combination of C0{sub 2} and placebo had significantly lower pain scores at 1 and 4 h (P=0.00 and P=0.014, respectively; Kruskal-Wallis test) compared with all other groups. Having Mebeverine as a pre-medication did not significantly lower pain scores compared with placebo, and decreased the amount of benefit received from the CO{sub 2}. We confirm that CO{sub 2} is of benefit in decreasing pain during barium enema, and we recommend its routine use to improve the comfort of patients. Mebeverine is not of benefit, and its use as a pre-medication for enemas is not recommended. (orig.)

  18. Long-acting reversible hormonal contraception

    African Journals Online (AJOL)

    Abstract. Long-acting reversible hormonal contraceptives are effective methods of birth control that provide contraception for an extended ... The World Health Organization (WHO) has online tools available .... trials and marketing experience.

  19. The role of Einstein's general relativity theory in today's physics

    International Nuclear Information System (INIS)

    Bicak, J.

    The relationships are discussed of the general relativity theory to other fields of today's physics. Recent results are reported of studies into gravitational radiation, relativistic astrophysics, cosmology and the quantum theory. (Z.M.)

  20. The University as an Institution Today: Topics for Reflection | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Today, in both the developing and industrialized worlds, the vital role of higher ... However, as the end of the second millennium draws near, we must reflect upon the ... Its philosophy, missions, functions, objectives, structures, and service to ...

  1. The Nazi Physicians as Leaders in Eugenics and "Euthanasia": Lessons for Today.

    Science.gov (United States)

    Grodin, Michael A; Miller, Erin L; Kelly, Johnathan I

    2018-01-01

    This article, in commemoration of the 70th anniversary of the Doctors' Trial at Nuremberg, reflects on the Nazi eugenics and "euthanasia" programs and their relevance for today. The Nazi doctors used eugenic ideals to justify sterilizations, child and adult "euthanasia," and, ultimately, genocide. Contemporary euthanasia has experienced a progression from voluntary to nonvoluntary and from passive to active killing. Modern eugenics has included both positive and negative selective activities. The 70th anniversary of the Doctors' Trial at Nuremberg provides an important opportunity to reflect on the implications of the Nazi eugenics and "euthanasia" programs for contemporary health law, bioethics, and human rights. In this article, we will examine the role that health practitioners played in the promotion and implementation of State-sponsored eugenics and "euthanasia" in Nazi Germany, followed by an exploration of contemporary parallels and debates in modern bioethics. 1 .

  2. Yesterday's, today's and tomorrow's nuclear tests of India and Pakistan

    International Nuclear Information System (INIS)

    Duval, M.; Le Guelte, G.

    1998-01-01

    This paper presents the historical aspects that led India and Pakistan to develop nuclear weapons and to perform nuclear weapon tests: weapons acquisition: today's military capacity, help from foreign countries; motivations: nuclear programs, geo-political aspects; results and potentialities; consequences for the non-proliferation systems and for the cut-off convention and test-ban treaties; and the geo-strategic consequences of todays's military nuclear capacity of India and Pakistan. (J.S.)

  3. Clinical Trials

    Medline Plus

    Full Text Available ... Clinical Trials About Clinical Trials Clinical trials are research studies that explore whether a medical strategy, treatment, or ... humans. What Are Clinical Trials? Clinical trials are research studies that explore whether a medical strategy, treatment, or ...

  4. Announcing the Sociation Today Urban Sociology and Reprint Collection Series

    Directory of Open Access Journals (Sweden)

    George H. Conklin

    2007-11-01

    Full Text Available "Sociation Today" is happy to announce the Urban Sociology Reprint Series. Other reprints will be focused on DuBois and his work available on-line, while the Max Weber video now has its own page. Articles printed in the current and past issues of Sociation Today have been gathered together in one place so they can be viewed conviently. The MENU link to the left will direct you to the proper place, as will the link above (for the urban reprints. The files will enable you to see the articles on a specific topic in one place, and also will enable the professor to assign the articles easily in classes. As an open access journal, Sociation Today's goal remains to provide scholars, the public and students with refereed articles exploring the nature of society and its interactions at no charge, unlike traditional journals and JSTOR.

  5. The AFIT of Today is the Air Force of Tomorrow

    Science.gov (United States)

    2012-05-11

    marketing 5/11/2012 9 The AFIT of today is the Air Force of tomorrow. 1 Air University: The Intellectual and Leadership Center of the Air Force Aim High...Center of the Air Force Aim High…Fly - Fight - Win The AFIT of Today is the Air Force of Tomorrow. LS Accomplishments • Initiated market -based, fee-for...USAFA Swarming Formation Flying Sponsor: SMC Space Traffic Control Iridium and Globalstar Modems Sponsor: AFRL/RV; SMC/ STP CubeSat Plume Detector

  6. The U.S. Constitution in Today's World.

    Science.gov (United States)

    Patrick, John J.

    A comparative study of constitutions and governments in world history is a key to deeper understanding of the U.S. Constitution. While many countries have constitutions, the United States is among a minority of nations in today's world that has a constitutional government. Many nations' constitutions truly guarantee few protections of individual…

  7. Grave New World? Workplace Skills for Today's College Graduates

    Science.gov (United States)

    Eisner, Susan

    2010-01-01

    Today's college graduates face an uncertain and demanding job market in which they are likely to encounter evolving skill needs, reduced hiring, and heightened competition from experienced laid off workers and globally available labor. These realities underscore the importance expressed by educators and practitioners of identifying attributes new…

  8. Organizing a Ground Crew for Today's Helicopter Parents

    Science.gov (United States)

    Coburn, Karen Levin

    2006-01-01

    The relationship between college students and their parents is far closer than it was when most of today's educators were in school. Tapping into the upside and managing the potential drawbacks of highly involved parents is taking on great importance on an increasing number of campuses. Whether people call them "helicopter parents" or…

  9. The power of data: structural bioinformatics yesterday and today

    KAUST Repository

    Tramontano, Anna

    2016-01-01

    The protein structure database was established in 1971. At the time it contained seven structures, today there are more than 100,000. The improvement is not only a matter of quantity, but also of quality. Did we effectively exploit this information

  10. Today's College Students: Going First Class on the Titanic.

    Science.gov (United States)

    Levine, Arthur

    1981-01-01

    There is a sense among today's students that they are passengers on a sinking ship, even though they are optimistic about their own futures. A new curriculum including interdisciplinary study, majors in problems rather than disciplines, career internships, and theses is proposed to counter student attitudes. (MSE)

  11. Important techniques in today's biomedical science research that ...

    African Journals Online (AJOL)

    The need for best evidence has driven researchers into multidisciplinary, collaborative approaches which have become mainstay in today's biomedical science. The multidisciplinary and collaborative approaches to research in research-intensive academic medical centres in the USA and in other countries of affluence has ...

  12. Surrounded by Water: Talking to Learn in Today's Classrooms

    Science.gov (United States)

    Ernst-Slavit, Gisela; Wenger, Kerri J.

    2016-01-01

    The authors explore the importance of talk and interaction for learning, particularly in relation to new K-12 standards and the prominent role of academic language in today's educational contexts. The article concludes with a detailed example of a Grade 6 teacher's use of content and language objectives to address the needs and strengths of all…

  13. Russia Today : Ruslands internationale spreekbuis voor 'soft power'?

    NARCIS (Netherlands)

    Kraft van Ermel, Nicolaas

    2014-01-01

    The tense current relations between Russia, Ukraine and the West are characterised by a true media war. This media war is fought in the old as well as in the new media, for example on television. One of the players in this game is the Russian English language television station Russia Today (since

  14. What Do Young People Today Really Think about Jesus?

    Science.gov (United States)

    Walshe, Karen

    2005-01-01

    This article presents the key findings of a recent study investigating young people's knowledge and understanding of Jesus and demonstrates how young people today appear to be experiencing the same difficulties when engaging with the figure of Jesus in the religious education classroom as they did almost 40 years ago. It concludes by suggesting…

  15. Acoustics of ancient Greek and Roman theaters in use today

    DEFF Research Database (Denmark)

    Gade, Anders Christian; Angelakis, Konstantinos

    2006-01-01

    In the Mediteranan area a large number of open, ancient Greek and Roman theatres are still today facing a busy schedule of performances including both classical and contemporary works of dance, drama, concerts, and opera. During the EU funded ``Erato'' project and a subsequent master thesis project...

  16. Some Distinctive Features of Jesuit Higher Education Today

    Science.gov (United States)

    Currie, Charles L.

    2010-01-01

    The nation's Catholic colleges and universities are recommitting themselves to making their founding visions come alive in increasingly effective and innovative ways. This article describes the Jesuit tradition of higher education, discussing its origins and how it is reflected in the reality and practice of Jesuit higher education today. This is…

  17. National Guard > About the Guard > Today in Guard History

    Science.gov (United States)

    National Guard About Us By the Numbers Contact Us FAQ Federal Mission History Join Us Leaders Director of Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training March Today in Guard History Leadership CNGB VCNGB SEA DANG DARNG Joint Staff J-1 J-2 J-3 J-4 J-5 J-6 J

  18. Education of Women in Today's World: Implications for Counsellors ...

    African Journals Online (AJOL)

    The result for research questions two revealed that all the items listed were accepted as problems of women in education sector. The third research question also revealed that all the items listed were accepted as things which education has done in the lives of women in Today's World, implications for Counsellors were also ...

  19. Voces (Voices): A Profile of Today's Latino College Students

    Science.gov (United States)

    Santiago, Deborah A.

    2007-01-01

    Latinos are the youngest and fastest growing ethnic group in the United States. It is imperative that institutional leaders and decision makers have a better understanding of Latino students today in order to shape the policies and practices to serve college students in the future. Currently, disparate statistics about Latino students in higher…

  20. Entrepreneurialism for Canadian Principals: Yesterday, Today, and Tomorrow

    Science.gov (United States)

    Scott, Shelleyann; Webber, Charles F.

    2013-01-01

    This article explores the various elements of Canadian educational entrepreneurialism as manifested yesterday, today, and tomorrow and in relation to the social and political influences of the time. This discussion is informed by the findings of the International Study of the Preparation of Principals (ISPP) and represents an expansion of the…

  1. Moments for Movement: Photostories from the 1980s Resonate Today

    Science.gov (United States)

    Barndt, Deborah; Erickson, Kris

    2017-01-01

    This chapter offers an intergenerational reflection on the production of photostories in the Toronto-based Moment Project of the 1980s, considering how its features of co-creation, creative forms, and critical social content could be reinvented with the new digital media forms integral to today's social movements.

  2. Visions of Students Today: A Message from the Editors

    Science.gov (United States)

    Wentzell, G. W.; Richlin, L.; Cox. M. D.

    2012-01-01

    In Michael Wesch's (2007) now widely seen video "A Vision of Students Today" (http://www.youtube.com/watch?v=dGCJ46vyR9o), a camera pans across a large, traditional classroom where college students hold up messages about themselves as members of the current generation of learners, who have been dubbed Millennials (Howe & Strauss, 2000). The video…

  3. Approaches to the Study of Pragmatism in Today's China

    Science.gov (United States)

    Chengbing, Wang

    2017-01-01

    To explore the key approaches to pragmatism is not only a logical requirement of the development of pragmatism itself, but also necessary for Chinese pragmatism to progress. There are three major necessary and feasible approaches to the study of pragmatism, which will play a very important role in the development of Pragmatism in today's China:…

  4. Filial obligations today : moral practice, perception and ethical theory

    NARCIS (Netherlands)

    Stuifbergen, M.C.

    2011-01-01

    This thesis is about the meaning of filial obligations in Dutch society today. The thesis consists of a general introduction, two quantitative sociological studies, two qualitative studies, an ethical analysis and a general discussion. In the introduction, the background for the research questions

  5. Interfaith Education: A New Model for Today's Interfaith Families

    Science.gov (United States)

    Gordon, Sheila C.; Arenstein, Benjamin

    2017-01-01

    With societal changes rapidly transforming cultures that had been largely homogenous, today's multi-cultural--and in particular interfaith--families need new educational strategies to help them understand their cultural roots and identify and clarify what aspects of their heritages they wish to nurture and transmit to their children. This paper…

  6. Dance, Sexuality, and Education Today: Observations for Dance Educators

    Science.gov (United States)

    Risner, Doug S.

    2004-01-01

    This paper aims to provide a comprehensive discussion of sexuality and dance education from multiple perspectives including public schools (K-12), private studios, conservatories, and higher education. Among innumerable potential topics emanating from this review of sexuality and dance education in the 21st century, this article focuses on today's…

  7. Chemistry Today and Tomorrow-The Central, Useful, and Creative ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 5. Chemistry Today and Tomorrow – The Central, Useful and Creative Science. Uday Maitra. Book Review Volume 2 ... Author Affiliations. Uday Maitra1. Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.

  8. Clinical Trials

    Medline Plus

    Full Text Available ... questions and clinical trials. Optimizing our Clinical Trials Enterprise NHLBI has a strong tradition of supporting clinical ... multi-pronged approach to Optimize our Clinical Trials Enterprise that will make our clinical trials enterprise even ...

  9. Clinical Trials

    Medline Plus

    Full Text Available ... to-kol). This plan explains how the trial will work. The trial is led by a principal ... for the clinical trial. The protocol outlines what will be done during the clinical trial and why. ...

  10. Clinical Trials

    Medline Plus

    Full Text Available ... take part in a clinical trial. When researchers think that a trial's potential risks are greater than ... care costs for clinical trials. If you're thinking about taking part in a clinical trial, find ...

  11. Clinical Trials

    Medline Plus

    Full Text Available ... of clinical trials contribute to medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are ... earlier than they would be in general medical practice. This is because late-phase trials have large ...

  12. Clinical Trials

    Medline Plus

    Full Text Available ... clinical trials contribute to medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are a ... will be done during the clinical trial and why. Each medical center that does the study uses ...

  13. Clinical Trials

    Medline Plus

    Full Text Available ... medical strategy, treatment, or device is safe and effective for humans. What Are Clinical Trials? Clinical trials ... and Centers sponsor clinical trials. Many other groups, companies, and organizations also sponsor clinical trials. Examples include ...

  14. Clinical Trials

    Medline Plus

    Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... kol). This plan explains how the trial will work. The trial is led by a principal investigator ( ...

  15. ACT Internet-based vs face-to-face? A randomized controlled trial of two ways to deliver Acceptance and Commitment Therapy for depressive symptoms: an 18-month follow-up.

    Science.gov (United States)

    Lappalainen, Päivi; Granlund, Anna; Siltanen, Sari; Ahonen, Suvi; Vitikainen, Minna; Tolvanen, Asko; Lappalainen, Raimo

    2014-10-01

    The aim of the present study was to investigate two interventions based on Acceptance and Commitment Therapy (ACT) for depressive symptoms: A face-to-face treatment (ACT group) was compared to a guided self-help treatment delivered via the Internet consisting of two assessment sessions (pre and post) and an ACT-based Internet program (iACT). Outpatients experiencing at least mild depressive symptoms were randomized to either approach. The iACT treatment group received access to an ACT-based Internet program and supportive web-based contact over a period of 6 weeks. The face-to-face group received ACT-based treatment once a week over the same period of time. In both groups, the results showed a significant effect on depression symptomatology, and general wellbeing after treatment and at the 18-month follow-up. However, the data indicated that the iACT group changed differently regarding depressive symptoms and wellbeing as compared to the face-to face ACT group. Results showed large pre-treatment to 18-month follow-up within-group effect sizes for all symptom measures in the iACT treatment group (1.59-2.08), and for most outcome measures in the face-to-face ACT group (1.12-1.37). This non-inferiority study provides evidence that guided Internet-delivered ACT intervention can be as effective as ACT-based face-to-face treatment for outpatients reporting depressive symptoms, and it may offer some advantages over a face-to-face intervention. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Clinical Trials

    Medline Plus

    Full Text Available ... Trial Protocol Each clinical trial has a master plan called a protocol (PRO-to-kol). This plan explains how the trial will work. The trial ... clinical trial; and detailed information about the treatment plan. Eligibility Criteria A clinical trial's protocol describes what ...

  17. Lung-MAP Launches: First Precision Medicine Trial From National Clinical Trials Network

    Science.gov (United States)

    A unique public-private collaboration today announced the initiation of the Lung Cancer Master Protocol (Lung-MAP) trial, a multi-drug, multi-arm, biomarker-driven clinical trial for patients with advanced squamous cell lung cancer. Squamous cell carcinom

  18. Against acts of nuclear terrorism

    International Nuclear Information System (INIS)

    Heller, W.

    2007-01-01

    The Act on the International Convention of the United Nations of April 13, 2005 on Combating Acts of Nuclear Terrorism was promulgated in the German Federal Gazette and entered into force one day later. The Convention expresses the deep concern about the worldwide escalation of all kinds and manifestations of acts of terrorism. What was true in April 2005 (the year the UN convention was adopted) is even more true today. At the same time, however, the Convention recognizes the right of all nations to develop and use nuclear power for peaceful purposes, acknowledging their justified interest in the possible benefits of the peaceful uses of nuclear power. As the Convention was signed in German still during the term of office of the Red-Green government, this passage is a remarkable acceptance of the realities of the world and past peaceful uses of nuclear power in Germany. Whether or not the convention will become an effective instrument to be used against acts of nuclear terrorism and threats depends on its entering into force after deposition of 22 ratification documents, and on as many states as possible acceding to it. Irrespective of these aspects, action in the spirit of the Convention should be taken now, criminal law should be adapted, and international cooperation should be improved and strengthened. (orig.)

  19. Difficult Past, Difficult Present?: How Collective Memory and Personal Experience Shape Beliefs on Politico-Cultural Identity in Post-Conflict Societies Today

    NARCIS (Netherlands)

    Leigh, James

    2013-01-01

    In essence, we are all products of our experience; thus the positions we adopt today are influenced by what we remember (and forget) about our past. This is true at both individual and collective levels. In societies traumatised by conflict, the act of recalling and dealing with the past is

  20. Today's research development on the application of the superconductivity transport system in Japan

    Science.gov (United States)

    Kyotani, Yoshihiro

    1995-01-01

    At the Miyazaki test track today, the new test vehicle, MLU002N, is under test run to obtain necessary data for Yamanashi test track where the construction is underway, the test vehicle has been ordered and the first tunnel was completed in December 1993. Superconducting magnetohydrodynamic drive ship, MHDS, 'Yamato 1' has completed its experiment in 1992 and it is now under preparation to exhibit to the public in___1994. Furthermore, to promote the research development of MHDS, the detailed discussion is underway on the magnetohydrodynamic drive equipment as well as the research on the future scheme. Neither an automobile nor railway but a new transport system called EQUOS LIM CAR(ELC) has been proposed. By using the rotating magnetic field, it will levitate on the aluminum like reaction plate. On the normal road, it will run by rolling the wheels like an electric car but on the highway, it will levitate on the guideway resulting to less noise, less vibration and pollution free drive. To understand the concept of the ELC, the model was built and experimented by using permanent magnet. The same model was donated to the MUSEUM OF SCIENCE AND INDUSTRY in Chicago and was displayed to the public. Today, the trial superconducting magnet has been made and the research development of the subsystem is underway. Research development of superconducting elevator, equipment for the launching of spaceship, tube transportation system and others are in progress for the superconducting applied transportation system.

  1. Clinical Trials

    Medline Plus

    Full Text Available ... Information Act (FOIA) Accessibility Copyright and Usage No FEAR Act Grants and Funding Building 31 31 Center ... Information Act (FOIA) Accessibility Copyright and Usage No FEAR Act Grants and Funding Building 31 31 Center ...

  2. Clinical Trials

    Medline Plus

    Full Text Available ... Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility Copyright and Usage No FEAR Act Grants and ... Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility Copyright and Usage No FEAR Act Grants and ...

  3. Wind power today: 1999 Wind Energy program highlights

    Energy Technology Data Exchange (ETDEWEB)

    Weis-Taylor, Pat

    2000-04-06

    Wind Power Today is an annual publication that provides an overview for the Department of Energy's Wind Energy Program. The purpose of Wind Power Today is to show how DOE's Wind Energy Program supports wind turbine research and deployment in hopes of furthering the advancement of wind technologies that produce clean, low-cost, reliable energy for the 21st century. Content objectives include: Educate readers about the advantages and potential for widespread deployment of wind energy; explain DOE wind energy program objectives and goals; describe program accomplishments in research and application; examine the barriers to widespread deployment; describe benefits of continued research and development; facilitate technology transfer; attract cooperative wind energy projects with industry.

  4. Energy financing in today's world - a banker's viewpoint

    International Nuclear Information System (INIS)

    Mackrell, Ian

    1991-01-01

    If the world runs on energy, the energy industry runs on finance. Supplying the industry's huge appetite for funds -on the scale and in the form required - has always posed a major challenge to the international banking community. But in some respects that challenge is greater today than it has ever been, not only because of the industry's escalating requirements but also because of the way bank's attitudes have been changing in the recent past. One reason for this is the rapidly evolving scene within the energy business in response to the harsher competitive conditions and the greater uncertainties of tomorrow. However, the other major factor is that banking itself has been undergoing significant change as a result of severe pressures and constraints, both internal and external. Some of the key global trends and issues affecting energy financing in today's world are considered here. (author)

  5. Energy financing in today's world - a banker's viewpoint

    Energy Technology Data Exchange (ETDEWEB)

    Mackrell, Ian [Barclays Bank plc, London (GB)

    1991-07-01

    If the world runs on energy, the energy industry runs on finance. Supplying the industry's huge appetite for funds -on the scale and in the form required - has always posed a major challenge to the international banking community. But in some respects that challenge is greater today than it has ever been, not only because of the industry's escalating requirements but also because of the way bank's attitudes have been changing in the recent past. One reason for this is the rapidly evolving scene within the energy business in response to the harsher competitive conditions and the greater uncertainties of tomorrow. However, the other major factor is that banking itself has been undergoing significant change as a result of severe pressures and constraints, both internal and external. Some of the key global trends and issues affecting energy financing in today's world are considered here. (author).

  6. Wind Power Today: 2000 Wind Energy Program Highlights

    Energy Technology Data Exchange (ETDEWEB)

    Weis-Taylor, W.

    2001-05-08

    Wind Power Today is an annual publication that provides an overview of the U.S. Department of Energy's Wind Energy Program. The purpose of Wind Power Today is to show how DOE's Wind Energy Program supports wind turbine research and deployment in hopes of furthering the advancement of wind technologies that produce clean, low-cost, reliable energy. Content objectives include: educate readers about the advantages and potential for widespread deployment of wind energy; explain the program's objectives and goals; describe the program's accomplishments in research and application; examine the barriers to widespread deployment; describe the benefits of continued research and development; facilitate technology transfer; and attract cooperative wind energy projects with industry.

  7. Including estimates of the future in today's financial statements

    OpenAIRE

    Mary Barth

    2006-01-01

    This paper explains why the question is how, not if, today's financial statements should include estimates of the future. Including such estimates is not new, but their use is increasing. This increase results primarily because standard setters believe asset and liability measures that reflect current economic conditions and up-to-date expectations of the future will result in more useful information for making economic decisions, which is the objective of financial reporting. This is why sta...

  8. The Pauli-Jung conjecture and its impact today

    CERN Document Server

    Fuchs, Christopher A

    2014-01-01

    Related to the key areas of Pauli''s and Jung''s joint interests, the book covers overlapping issues from the perspectives of physics, philosophy, and psychology. Of primary significance are epistemological questions connected to issues such as realism, measurement, observation, consciousness, and the unconscious. The contributions assess the extensive material that we have about Pauli''s and Jung''s ideas today, with particular respect to concrete research questions and projects based on and re...

  9. Poverty in Capitalism. Why is it Persisting Today?

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Isidro Luna

    2013-11-01

    Full Text Available The purpose of this paper is to provide elements to reflect on the way poverty is nowadays conceptualized and on its causing factors. This paper discusses that a classic-neoclassical frame of reference cannot explain the persistence or increase of poverty in today's developed countries. This article suggests that through a Marxist historic-descriptive and theoretical-logical method it may be possible to gain understanding about poverty in capitalism and its current evolution.

  10. Prevention of Malnutrition in Children, Slimming Yesterday, Obesity Today

    OpenAIRE

    S Sharafi; M Razi; Z Pouresmail

    2014-01-01

    Introduction: The future of any nation depends on how its children's care, According to their likely future health needs of the adult population model for healthy living and wealth has increased. One of the most pressing health diet. This study is done to aimed investigate the factors influencing malnutrition in children in the past for weight loss and weight gain can be seen today.   Methods and Methods: Related articles referring to achieve in the field of databases to Google scholar, Pub M...

  11. Energy supply today and tomorrow, national and global

    International Nuclear Information System (INIS)

    Ott, G.

    2003-01-01

    A status report about 'Energy Supply Today and Tomorrow, National and Global' focuses mainly on global aspects. Today's world energy consumption is dominated by more than 80% of fossil sources of energy followed by so-called non-commercial energies, such as wood and plant and animal wastes, contributing 10%; nuclear power, 7%; and hydroelectric power, 2%. The development of energy consumption until the middle of this century will continue to be driven by the further growth of the world population, and by the need to meet the rising demand for energy in the developing countries. Because of their availability and flexible uses, oil, natural gas, and coal as fossil sources of energy will continue to meet a considerable share of the requirement. The use of nuclear power, a source meeting all criteria, such as safety, waste management, and competitiveness, is both justifiable and desirable. Restrictive decisions about nuclear power taken today must not impair the freedom of choice of future generations. Using renewable energies is just as desirable as increasing energy efficiency; however, the technical and physical potentials available for this purpose should not be overrated. This makes it imperative to protect the supply of energy 'in this difficult interim phase' with all the options available, and to open up prospects for the future, also by conducting the appropriate energy and environmental research. The balance between continuity of supply, environmental compatibility, and competitiveness must be taken into account in this effort. In the second half of the 21 st century, it is possible that energy consumption will stabilize when the world's population ceases to grow. New technologies, some of which may not even be known today or may still be under development, could then pave the way for an energy supply system which, in toto, would be less of a burden on the environment. (orig.)

  12. Medium Term Economic Effects of Peak Oil Today

    OpenAIRE

    Dr. Ulrike Lehr; Dr. Christian Lutz; Kirsten Wiebe

    2011-01-01

    The paper at hand presents results of a model-based scenario analysis on the economic implications in the next decade of an oil peak today and significantly decreasing oil production in the coming years. For that the extraction paths of oil and other fossil fuels given in LBST (2010) are implemented in the global macroeconomic model GINFORS. Additionally, the scenarios incorporate different technological potentials for energy efficiency and renewable energy, which cannot be forecast using eco...

  13. Research Today Volume 3, Issue 2 April 2017 Newsletter

    Science.gov (United States)

    2017-05-05

    for your study [ e.g., 59 MDW CRD Graduate Health Sciences Education (GHSE) (SG5 O&M); SG5 R&D; Tri-Service Nursing Research Program (TSNRP); Defense...59 MDW/SGVU SUBJECT: Professional Presentation Approval 1. Your paper, entitled Research Today Volume 3, Issue 2 April 2017 - Newsletter presented...Hall Ambulatory Surgical Center (WHASC) internship and residency programs. 3. Please know that if you are a Graduate Health Sciences Education

  14. [The practicum in physiology: from Laufberger to today].

    Science.gov (United States)

    Kuthan, V; Sedlácek, J; Trojan, S

    1990-09-21

    An outline of Prof. Laufberger's concept of practical exercises in physiology, proposed just after the Second World War, is given. Especially, his new pedagogical approach is emphasized, here. Further, the development of the organization of practical courses in the Institute of Physiology in Prague is described: e.g. the modernization of the methods used, and of the educational process in early 70 s'. Today, the importance of biocybernetics is growing.

  15. Wind Power Today: Wind Energy Program Highlights 2001

    Energy Technology Data Exchange (ETDEWEB)

    2002-05-01

    Wind Power Today is an annual publication that provides an overview of the U.S. Department of Energy's Wind Energy Program accomplishments for the previous year. The purpose of Wind Power Today is to show how DOE's Wind Energy Program supports wind turbine research and deployment in hopes of furthering the advancement of wind technologies that produce clean, low-cost, reliable energy. Content objectives include: educate readers about the advantages and potential for widespread deployment of wind energy; explain the program's objectives and goals; describe the program's accomplishments in research and application; examine the barriers to widespread deployment; describe the benefits of continued research and development; facilitate technology transfer; and attract cooperative wind energy projects with industry. This 2001 edition of Wind Power Today also includes discussions about wind industry growth in 2001, how DOE is taking advantage of low wind speed regions through advancing technology, and distributed applications for small wind turbines.

  16. "Children are from heaven" or how today children respect adults

    Directory of Open Access Journals (Sweden)

    Barbara Vogrinec

    2007-06-01

    Full Text Available The starting point of the text is a returning to the patriarchal, which is not simply the one that we are witnessing today, in the time of so-called postmodern, postpatriarchal society in its (until now last form. It is a matter of returning to rules, of which the basic premise is that adults are subjects (transcendences, freedoms, activities and children are subjects that are objects for adults (imanences, non-freedoms, pasivities, but which notwithstanding differ from the oldfashioned rules from the past. We attempted to explain this returning, following the example of rules offered by the book Children Are From Heaven – a selfhelp book, published at the end of the nineties of the 20th century, which immediately became the world's bestseller. In addition, our aim was to answer the following questions: What has happened with rules of civilization and good manners, regulating the relations between children and adults today? How have they changed and what has happened with children's or adults's relation to these rules or their performings? How has this relation changed? Considering the mentioned basic premise which implies that children respect adults, we also tried to answer the question: What has happened with the respect, or, how do children respect adults today? Disscussion is presented in the framework of lacanian psychoanalysis.

  17. Clinical Trials: A Crucial Key to Human Health Research

    Science.gov (United States)

    ... Past Issues Clinical Trials: A Crucial Key to Human Health Research Past Issues / Summer 2006 Table of Contents ... Javascript on. Photo: PhotoDisc At the forefront of human health research today are clinical trials—studies that use ...

  18. Comparing Effectiveness of Active and Passive Client Follow-Up Approaches in Sustaining the Continued Use of Long Acting Reversible Contraceptives (LARC) in Rural Punjab: A Multicentre, Non-Inferiority Trial

    Science.gov (United States)

    Hameed, Waqas; Azmat, Syed Khurram; Ali, Moazzam; Ishaque, Muhammad; Abbas, Ghazunfer; Munroe, Erik; Harrison, Rebecca; Shamsi, Wajahat Hussain; Mustafa, Ghulam; Khan, Omar Farooq; Ali, Safdar; Ahmed, Aftab

    2016-01-01

    Background The use of long-acting reversible contraceptive (LARC) methods is very low in Pakistan with high discontinuation rates mainly attributed to method-related side effects. Mixed evidence is available on the effectiveness of different client follow-up approaches used to ensure method continuation. We compared the effectiveness of active and passive follow-up approaches in sustaining the use of LARC—and within ‘active’ follow-up, we further compared a telephone versus home-based approach in rural Punjab, Pakistan. Methods This was a 12-month multicentre non-inferiority trial conducted in twenty-two (16 rural- and 6 urban-based) franchised reproductive healthcare facilities in district Chakwal of Punjab province, between November 2013 and December 2014. The study comprised of three groups of LARC clients: a) home-based follow-up, b) telephone-based follow-up, and c) passive or needs-based follow-up. Participants in the first two study groups received counselling on scheduled follow-up from the field workers at 1, 3, 6, 9, and 12 month post-insertion whereas participants in the third group were asked to contact the health facility if in need of medical assistance relating to LARC method use. Study participants were recruited with equal allocation to each study group, but participants were not randomized. The analyses are based on 1,246 LARC (intra-uterine contraceptive device and implant) users that completed approximately 12-months of follow-up. The non-inferiority margin was kept at five percentage points for the comparison of active and passive follow-up and six percentage points for telephone and home-based approach. The primary outcome was cumulative probability of method continuation at 12-month among LARC users. Results Women recruited in home-based, telephone-based, and passive groups were 400, 419 and 427, respectively. The cumulative probability of LARC continuation at 12 month was 87.6% (95% CI 83.8 to 90.6) among women who received home

  19. IN TODAY'S INFORMATION AGE ORGANISATIONS EXECUTIVE ASSISTANT PROFESSION

    Directory of Open Access Journals (Sweden)

    Bekir DEĞİRMENCİ

    2015-07-01

    Full Text Available It's as old as human history in the Executive Office and of the concept has caused the unborn. From the industrial revolution, they perform the organizational activities of all employees in the area are the name of the Office. Businesses are not just places that made production. Businesses also allows the production of all kinds of people have seen the need, the important strategic decisions, increase the quali ty of production and employees must work efficiently and effectively - conscious upon arrival places always have been offices. Marketing, management, human resources, accounting, as units have been operating in all offices within the organization. In today' s information age, information offices are produced, distributed to individuals and corporations concerned, but also has been the destruction of redundant information and important information later when needed has been used places. Today's globalization i s rapid change in knowledge and technology organizations in the management of business owners and managers will help many professions on WikiMapia. Office; Administrator, officer, Secretary, will serve the objectives of the business class ser vices help kin d of elements are needed. Businesses in maintaining vital activities, production and service provision of the activities of the Organization in ensuring an effective and efficient manner within the framework of the team spirit in the conduct of managers with the most important requirements for an Assistant Manager's position has been. Most modern - day organizations close to the administrator should be looking to key features of the Administrative Assistant; the Office of the administrator, who knows how t o keep a secret is not a characteristic of people who best represent the Bureau. When a business can stand in straight execution activities Administrative Assistant has important tasks to. Executive Assistants are indispensable ingredients of today's mode rn office.

  20. Clinical Trials

    Medline Plus

    Full Text Available ... protocol affect the trial's results. Comparison Groups In most clinical trials, researchers use comparison groups. This means ... study before you agree to take part. Randomization Most clinical trials that have comparison groups use randomization. ...

  1. Clinical Trials

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    Full Text Available ... clinical trials are vital to the process of improving medical care. Many people volunteer because they want ... care costs for clinical trials. If you're thinking about taking part in a clinical trial, find ...

  2. Clinical Trials

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    Full Text Available ... or vulnerable patients (such as children). A DSMB's role is to review data from a clinical trial ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ...

  3. Clinical Trials

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    Full Text Available ... Clinical Trials About Clinical Trials Clinical trials are research studies that explore whether a medical strategy, treatment, ... required to have an IRB. Office for Human Research Protections The U.S. Department of Health and Human ...

  4. Clinical Trials

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    Full Text Available ... Trials About Clinical Trials Clinical trials are research studies that explore whether a medical strategy, treatment, or ... and Clinical Studies Web page. Children and Clinical Studies Learn more about Children and Clinical Studies Importance ...

  5. Clinical Trials

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    Full Text Available ... criteria differ from trial to trial. They include factors such as a patient's age and gender, the ... bias. "Bias" means that human choices or other factors not related to the protocol affect the trial's ...

  6. Clinical Trials

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    Full Text Available ... more information about eligibility criteria, go to "How Do Clinical Trials Work?" Some trials enroll people who ... for adults. For more information, go to "How Do Clinical Trials Protect Participants?" For more information about ...

  7. Clinical Trials

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    Full Text Available ... you agree to take part in the trial. Talk with your doctor about specific trials you're ... part in a clinical trial is your decision. Talk with your doctor about all of your treatment ...

  8. Clinical Trials

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    Full Text Available ... any clinical trial before you agree to take part in the trial. Talk with your doctor about specific trials you're interested in. For a list of questions to ask your doctor and the ...

  9. Clinical Trials

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    Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... study? How might this trial affect my daily life? Will I have to be in the hospital? ...

  10. Clinical Trials

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    Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... from a study at any time, for any reason. Also, during the trial, you have the right ...

  11. Clinical Trials

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    Full Text Available ... or device is safe and effective for humans. What Are Clinical Trials? Clinical trials are research studies ... parents, clinicians, researchers, children, and the general public. What to Expect During a clinical trial, doctors, nurses, ...

  12. Clinical Trials

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    Full Text Available ... under way. For example, some trials are stopped early if benefits from a strategy or treatment are ... stop a trial, or part of a trial, early if the strategy or treatment is having harmful ...

  13. Karl Marx and the Study of Media and Culture Today

    OpenAIRE

    Christian Fuchs

    2014-01-01

    The task of this paper discusses the role of Marx in analysing media, communica-tion and culture today. An analysis of three contemporary Cultural Studies works – Lawrence Grossberg’s monograph Cultural Studies in the Future Tense, John Hartley’s monograph Digital Futures for Cultural and Media Studies and Paul Smith’s edited volume The Renewal of Cultural Studies – shows that there is an agreement that the economy needs to be taken more into account by Cultural Studies, but disagreement on w...

  14. The end of the line for today's wind turbines

    OpenAIRE

    Kolios, Athanasios; Martinez-Luengo, Maria

    2016-01-01

    We need to start thinking today about the future of our wind turbines, according to Dr Athanasios Kolios and María Martínez-Luengo from Cranfield University. EDF's recent announcement that they will extend the life of 4 of their 8 UK-based nuclear power plants has focussed analyst's minds on the pros and cons of extending service life. There are numerous cost and engineering issues at play here. These obviously include balancing the initial investment cost against profits already made...

  15. The most critical issues facing managers in South Africa today

    Directory of Open Access Journals (Sweden)

    G. Maritz

    2002-12-01

    Full Text Available South African managers today find themselves squeezed between juxtapositions, such as international competition and simultaneous skill development programmes to combat illiteracy. A second example is high unemployment and the concurrent shortage of IT specialists. Affirmative action has led to troublesome labour relations. HIV/AIDS has an enormous impact on business and must be managed. South African managers need to change their managerial approaches to cope with the increasing demands of this country. Managers must be aware of the realities facing them and know how to turn them into potential growth opportunities for their organisations and South Africa as a country.

  16. Church and art: from the second Vatican Council to today

    Directory of Open Access Journals (Sweden)

    Mauro Mantovani

    2014-12-01

    Full Text Available This text deals with the relationship between the Catholic Church and art from the Second Vatican Council to today. For this reason it considers some of the most important interventions about art by recent popes (Montini - Paul VI; Wojtyła - John Paul II; Ratzinger - Benedict XVI, Bergoglio - Francis also mentioning some activities that the Holy See is currently promoting. These pages are intended to offer a contribution, mainly theoretical, for those who are working in the field of the planning and promotion of artistic and cultural events, especially if these events are related to religious heritage.

  17. Atomic Energy Commission Act, 2000 (Act 588)

    International Nuclear Information System (INIS)

    2000-01-01

    Act 588 of the Republic of Ghana entitled, Atomic Energy Commission Act, 2000, amends and consolidates the Atomic Energy Commission Act, 204 of 1963 relating to the establishment of the Atomic Energy Commission. Act 588 makes provision for the Ghana Atomic Energy Commission to establish more institutes for the purpose of research in furtherance of its functions and also promote the commercialization of its research and development results. (E.A.A.)

  18. [Euthanasia and medical act].

    Science.gov (United States)

    2011-05-01

    Right to life -as the prohibition of intentionally and arbitrarily taking life, even with authorization of the concerned one- is an internationally recognized right. In many countries, debate regarding euthanasia is more centered in its convenience, social acceptability and how it is regulated, than in its substantial legitimacy. Some argue that euthanasia should be included as part of clinical practice of health professionals, grounded on individual's autonomy claims-everyone having the liberty to choose how to live and how to die. Against this, others sustain that life has a higher value than autonomy, exercising autonomy without respecting the right to life would become a serious moral and social problem. Likewise, euthanasia supporters some-times claim a 'right to live with dignity', which must be understood as a personal obligation, referred more to the ethical than to the strictly legal sphere. In countries where it is already legalized, euthanasia practice has extended to cases where it is not the patient who requests this but the family or some healthcare professional, or even the legal system-when they think that the patient is living in a condition which is not worthy to live. Generalization of euthanasia possibly will end in affecting those who need more care, such as elder, chronically ill or dying people, damaging severely personal basic rights. Nature, purpose and tradition of medicine rule out the practice of euthanasia, which ought not be considered a medical act or legitimately compulsory for physicians. Today's medicine counts with effective treatments for pain and suffering, such as palliative care, including sedative therapy, which best preserves persons dignity and keeps safe the ethos of the medical profession.

  19. Research and Science Today Supplement No. 3/2015

    Directory of Open Access Journals (Sweden)

    Adriana BUTCOVAN

    2015-07-01

    Full Text Available RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics. We provide the authors with the opportunity to create and/or perfect their science writing skills. Thus, each issue of the journal (two per year and at least two supplements will contain professional articles from any academic field, authored by domestic and international academics. The goal of this journal is to pass on relevant information to undergraduate, graduate, and post-graduate students as well as to fellow academics and researchers; the topics covered are unlimited, considering its multi-disciplinary profile. Regarding the national and international visibility of Research and Science Today, it is indexed in over 30 international databases (IDB and is present in over 200 online libraries and catalogues; therefore, anybody can easily consult the articles featured in each issue by accessing the databases or simply the website.

  20. Research and Science Today No. 2(4/2012

    Directory of Open Access Journals (Sweden)

    VĂIDEAN Amelia-Liana

    2012-11-01

    Full Text Available RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics. We provide the authors with the opportunity to create and/or perfect their science writing skills. Thus, each issue of the journal (two per year and at least two supplements will contain professional articles from any academic field, authored by domestic and international academics. The goal of this journal is to pass on relevant information to undergraduate, graduate, and post-graduate students as well as to fellow academics and researchers; the topics covered are unlimited, considering its multi-disciplinary profile. Regarding the national and international visibility of Research and Science Today, it is indexed in over 30 international databases (IDB and is present in over 200 online libraries and catalogues; therefore, anybody can easily consult the articles featured in each issue by accessing the databases or simply the website.

  1. Research and Science Today Supplement No. 1/2014

    Directory of Open Access Journals (Sweden)

    Elena-Steluţa DINU

    2014-07-01

    Full Text Available RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics. We provide the authors with the opportunity to create and/or perfect their science writing skills. Thus, each issue of the journal (two per year and at least two supplements will contain professional articles from any academic field, authored by domestic and international academics. The goal of this journal is to pass on relevant information to undergraduate, graduate, and post-graduate students as well as to fellow academics and researchers; the topics covered are unlimited, considering its multi-disciplinary profile. Regarding the national and international visibility of Research and Science Today, it is indexed in over 30 international databases (IDB and is present in over 200 online libraries and catalogues; therefore, anybody can easily consult the articles featured in each issue by accessing the databases or simply the website.

  2. Research and Science Today Supplement No. 2/2015

    Directory of Open Access Journals (Sweden)

    Tudor Cosmin CIOCAN

    2015-04-01

    Full Text Available RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics. We provide the authors with the opportunity to create and/or perfect their science writing skills. Thus, each issue of the journal (two per year and at least two supplements will contain professional articles from any academic field, authored by domestic and international academics. The goal of this journal is to pass on relevant information to undergraduate, graduate, and post-graduate students as well as to fellow academics and researchers; the topics covered are unlimited, considering its multi-disciplinary profile. Regarding the national and international visibility of Research and Science Today, it is indexed in over 30 international databases (IDB and is present in over 200 online libraries and catalogues; therefore, anybody can easily consult the articles featured in each issue by accessing the databases or simply the website.

  3. Research and Science Today Supplement No. 1/2016

    Directory of Open Access Journals (Sweden)

    Ana-Maria ADĂSCĂLIȚEI

    2016-08-01

    Full Text Available RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics. We provide the authors with the opportunity to create and/or perfect their science writing skills. Thus, each issue of the journal (two per year and at least two supplements will contain professional articles from any academic field, authored by domestic and international academics. The goal of this journal is to pass on relevant information to undergraduate, graduate, and post-graduate students as well as to fellow academics and researchers; the topics covered are unlimited, considering its multi-disciplinary profile. Regarding the national and international visibility of Research and Science Today, it is indexed in over 30 international databases (IDB and is present in over 200 online libraries and catalogues; therefore, anybody can easily consult the articles featured in each issue by accessing the databases or simply the website.

  4. Research and Science Today No. 2(2/2011

    Directory of Open Access Journals (Sweden)

    Adriana Rodica MUREŞAN

    2011-12-01

    Full Text Available RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics. We provide the authors with the opportunity to create and/or perfect their science writing skills. Thus, each issue of the journal (two per year and at least two supplements will contain professional articles from any academic field, authored by domestic and international academics. The goal of this journal is to pass on relevant information to undergraduate, graduate, and post-graduate students as well as to fellow academics and researchers; the topics covered are unlimited, considering its multi-disciplinary profile. Regarding the national and international visibility of Research and Science Today, it is indexed in over 30 international databases (IDB and is present in over 200 online libraries and catalogues; therefore, anybody can easily consult the articles featured in each issue by accessing the databases or simply the website.

  5. Research and Science Today Supplement No. 1/2015

    Directory of Open Access Journals (Sweden)

    Adrian Todor

    2015-01-01

    Full Text Available RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics. We provide the authors with the opportunity to create and/or perfect their science writing skills. Thus, each issue of the journal (two per year and at least two supplements will contain professional articles from any academic field, authored by domestic and international academics. The goal of this journal is to pass on relevant information to undergraduate, graduate, and post-graduate students as well as to fellow academics and researchers; the topics covered are unlimited, considering its multi-disciplinary profile. Regarding the national and international visibility of Research and Science Today, it is indexed in over 30 international databases (IDB and is present in over 200 online libraries and catalogues; therefore, anybody can easily consult the articles featured in each issue by accessing the databases or simply the website.

  6. Research and Science Today No. 1(1/2011

    Directory of Open Access Journals (Sweden)

    Alexandra DRĂGHICI

    2011-09-01

    Full Text Available RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics. We provide the authors with the opportunity to create and/or perfect their science writing skills. Thus, each issue of the journal (two per year and at least two supplements will contain professional articles from any academic field, authored by domestic and international academics. The goal of this journal is to pass on relevant information to undergraduate, graduate, and post-graduate students as well as to fellow academics and researchers; the topics covered are unlimited, considering its multi-disciplinary profile. Regarding the national and international visibility of Research and Science Today, it is indexed in over 30 international databases (IDB and is present in over 200 online libraries and catalogues; therefore, anybody can easily consult the articles featured in each issue by accessing the databases or simply the website.

  7. 3D and 4D Seismic Technics Today

    Directory of Open Access Journals (Sweden)

    Marcin Marian

    2004-09-01

    Full Text Available Years ago, exploration was done through surface observations and „divining rods“ – now, it is done by satellites, microprocessors, remote sensing, and supercomputers. In the 1970´ s, the exploration success rate was 14 percent, today, it is nearly 29 percent. Not so long ago, three – dimension (3D seismic diagnostic techniques helped recover 25-50 percent of the oil in place – now, 4D seismic helps recover up to 70 percent of the oil in place. 3D and 4D seismic and earth imaging systems also help in understanding the subsurface flow of other fluids, such as groundwater and pollutants.Seismic surveys – a technique in which sound waves are bounced off underground rock struktures to reveal possible oil and gas bearing formation – are now standard fare for the modern petroleum industry. But today’s seismic methods are best at locating „structural traps“ where faults or folds in the underground rock have created zones where oil can become trapped.

  8. Structure to utilize interventionists' implementation experiences of a family-based behavioral weight management program to enhance the dissemination of the standardized intervention: The TODAY study.

    Science.gov (United States)

    Chadwick, Jennifer Q; Van Buren, Dorothy J; Morales, Elisa; Timpson, Alexandra; Abrams, Ericka L; Syme, Amy; Preske, Jeff; Mireles, Gerardo; Anderson, Barbara; Grover, Nisha; Laffel, Lori

    2017-08-01

    Background For a 2- to 6-year period, interventionists for the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) randomized clinical trial delivered a family-based, behavioral weight-loss program (the TODAY Lifestyle Program) to 234 youth with type 2 diabetes. Interventionists held at least a bachelor's degree in psychology, social work, education, or health-related field and had experience working with children and families, especially from diverse ethnic and socioeconomic backgrounds. This article describes the administrative and organizational structure of the lifestyle program and how the structure facilitated collaboration among study leadership and lifestyle interventionists on the tailoring of the program to best suit the needs of the trial's diverse patient population. Methods During the pilot phase and throughout the duration of the trial, the interventionists' experiences in delivering the intervention were collected in a variety of ways including membership on study committees, survey responses, session audio recordings, and feedback during in-person trainings. Results The experiences of interventionists conveyed to study leadership through these channels resulted in decisions to tailor the lifestyle intervention's delivery location and ways to supplement the standardized educational materials to better address the needs of a diverse patient population. Conclusion The methods used within the TODAY study to encourage and utilize interventionists' experiences while implementing the lifestyle program may be useful to the design of future multi-site, clinical trials seeking to tailor behavioral interventions in a standardized, and culturally and developmentally sensitive manner.

  9. An Introduction to Flight Software Development: FSW Today, FSW 2010

    Science.gov (United States)

    Gouvela, John

    2004-01-01

    Experience and knowledge gained from ongoing maintenance of Space Shuttle Flight Software and new development projects including Cockpit Avionics Upgrade are applied to projected needs of the National Space Exploration Vision through Spiral 2. Lessons learned from these current activities are applied to create a sustainable, reliable model for development of critical software to support Project Constellation. This presentation introduces the technologies, methodologies, and infrastructure needed to produce and sustain high quality software. It will propose what is needed to support a Vision for Space Exploration that places demands on the innovation and productivity needed to support future space exploration. The technologies in use today within FSW development include tools that provide requirements tracking, integrated change management, modeling and simulation software. Specific challenges that have been met include the introduction and integration of Commercial Off the Shelf (COTS) Real Time Operating System for critical functions. Though technology prediction has proved to be imprecise, Project Constellation requirements will need continued integration of new technology with evolving methodologies and changing project infrastructure. Targets for continued technology investment are integrated health monitoring and management, self healing software, standard payload interfaces, autonomous operation, and improvements in training. Emulation of the target hardware will also allow significant streamlining of development and testing. The methodologies in use today for FSW development are object oriented UML design, iterative development using independent components, as well as rapid prototyping . In addition, Lean Six Sigma and CMMI play a critical role in the quality and efficiency of the workforce processes. Over the next six years, we expect these methodologies to merge with other improvements into a consolidated office culture with all processes being guided by

  10. Clinical Trials

    Medline Plus

    Full Text Available ... need to travel or stay in hospitals to take part in clinical trials. For example, the National Institutes of Health Clinical Center in ... Maryland, runs clinical trials. Many other clinical trials take place in medical centers and ... trial can have many benefits. For example, you may gain access to new treatments before ...

  11. Clinical Trials

    Medline Plus

    Full Text Available ... of clinical trials contribute to medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are a key ... Enterprise NHLBI has a strong tradition of supporting clinical trials that have not only shaped medical practice around the world, but have improved the health ...

  12. Clinical Trials

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    Full Text Available ... clinical trials. If you're thinking about taking part in a clinical trial, find out ahead of time about costs and coverage. You should learn about the risks and benefits of any clinical trial before you agree to take part in the trial. Talk with your doctor about ...

  13. Not All Parents Make the Grade in Today's Schools

    Science.gov (United States)

    Horvat, Erin McNamara; Baugh, David E.

    2015-01-01

    Expectations for parent involvement in their children's education have risen dramatically over the last 20 years. The demands now placed on parents to evaluate and select educational options for their children, to act as advocates for their children, and to support increasingly demanding academic standards have never been greater. Strong…

  14. Challenges of executing heavy oil projects in today's market

    International Nuclear Information System (INIS)

    Brunka, G.

    2001-01-01

    Alberta's industrial project scene from 1981 to 2000 was presented in this power point presentation with particular focus on proposed bitumen recovery projects and heavy oil project challenges. A graph depicting GTG world orders by region (Americas, Asia and Europe) showed that U.S. market continues to drive global growth. Major industrial projects in Alberta were highlighted and employment requirements by sector were outlined. In addition, mitigation measures that are needed to successfully deal with the unique challenges of today's market were described. It was noted that in recent years lower capital expenditure by the industry in general has resulted in corporate downsizing or mergers which in turn have resulted in lower technical and operational knowledge. Some of the current challenges facing the industry are new demands for water treatment expertise and an aging workforce. It was concluded that effective mitigation will require a disciplined approach within a flexible framework.1 tab., 7 figs

  15. Purex process extraction cycles: a potential for progress today

    Energy Technology Data Exchange (ETDEWEB)

    Boullis, B.; Germain, M.; Goumondy, J.P.; Rouyer, H.

    1994-12-31

    The Purex process very quickly and very widely supplanted the other concepts considered for nuclear fuel reprocessing after the presentation made at the Geneva Conference in 1955. The selectivity and radiolytic stability of tributylphosphate (T.B.P) clearly appeared to augur an extremely attractive process for completing the separation of valuable elements in the irradiated fuel. The concept has confirmed its validity, and subsequently its ability to adapt to changing requirements or constraints. Its industrial viability is in fact unquestioned today: Purex process is the basis of all the reprocessing plants in operation or planned throughout the world, and recent commissioning of the UP3 plant in France, in remarkable conditions, attests to such a level of maturity that one is tempted to ask the question: ``What remains to be proved, discovered or improved in the core of the Purex process?``. (authors). 7 refs., 4 tabs.

  16. Purex process extraction cycles: a potential for progress today

    International Nuclear Information System (INIS)

    Boullis, B.; Germain, M.; Goumondy, J.P.; Rouyer, H.

    1994-01-01

    The Purex process very quickly and very widely supplanted the other concepts considered for nuclear fuel reprocessing after the presentation made at the Geneva Conference in 1955. The selectivity and radiolytic stability of tributylphosphate (T.B.P) clearly appeared to augur an extremely attractive process for completing the separation of valuable elements in the irradiated fuel. The concept has confirmed its validity, and subsequently its ability to adapt to changing requirements or constraints. Its industrial viability is in fact unquestioned today: Purex process is the basis of all the reprocessing plants in operation or planned throughout the world, and recent commissioning of the UP3 plant in France, in remarkable conditions, attests to such a level of maturity that one is tempted to ask the question: ''What remains to be proved, discovered or improved in the core of the Purex process?''. (authors). 7 refs., 4 tabs

  17. Christian biblical ethics: the application of biblical norms to today

    Directory of Open Access Journals (Sweden)

    Patrick J. Hartin

    1991-03-01

    Full Text Available Christian theologians give many different interpretations to the Scriptures, particularly with regard to their ethical perspectives and their application to the present. An examination and criticism of various approaches adopted at present to the ethical dimension of the Scriptures is undertaken. A distinction is made between the revealed and lasting message of the Scriptitres and the message that is conditioned by culture and hence subject to change. Using the thought of Ricoeur and Hauerwas an approach is presented which attempts to do justice to the twofold polarity of the worid of the Bible and the world of today. In order to preserve a scenario of concreteness, attention is given to one practical example, namely the issue of homosexuality. After investigating the Scriptural approach to this question, an attempt is made to see how this issue can be viewed from a Christian perspective in the context of the present world.

  18. Cummins L10G in Kenworth truck 'viable today'

    International Nuclear Information System (INIS)

    Anon.

    1996-01-01

    As the culmination of five years of developmental work by Cummins Engines, BC Research Inc., and BC Gas Utility Ltd., a T800 Kenworth truck was outfitted with a new Cummins L10G natural gas engine, and two lightweight fully -wrapped Dynetek cylinders; it was pronounced to be 'a viable clean truck today'. The L10G spark-ignited engine operates at a relatively high peak efficiency of 37 per cent and is commercially available to meet the current California Air Resources Board heavy duty vehicle emission standards without the use of a catalytic converter. The L10G engine produces no particulate emissions, a very significant advantage, in view of the fact that particulate emissions have been identified as major contributors to respiratory ailments

  19. Crosscheck Principle in Pediatric Audiology Today: A 40-Year Perspective.

    Science.gov (United States)

    Hall, James W

    2016-09-01

    The crosscheck principle is just as important in pediatric audiology as it was when first described 40 years ago. That is, no auditory test result should be accepted and used in the diagnosis of hearing loss until it is confirmed or crosschecked by one or more independent measures. Exclusive reliance on only one or two tests, even objective auditory measures, may result in a auditory diagnosis that is not clear or perhaps incorrect. On the other hand, close and careful analysis of findings for a test battery consisting of objective procedures and behavioral tests whenever feasible usually leads to prompt and accurate diagnosis of auditory dysfunction. This paper provides a concise review of the crosscheck principle from its introduction to its clinical application today. The review concludes with a description of a modern test battery for pediatric hearing assessment that supplements traditional behavioral tests with a variety of independent objective procedures including aural immittance measures, otoacoustic emissions, and auditory evoked responses.

  20. Crosscheck Principle in Pediatric Audiology Today: A 40-Year Perspective

    Science.gov (United States)

    2016-01-01

    The crosscheck principle is just as important in pediatric audiology as it was when first described 40 years ago. That is, no auditory test result should be accepted and used in the diagnosis of hearing loss until it is confirmed or crosschecked by one or more independent measures. Exclusive reliance on only one or two tests, even objective auditory measures, may result in a auditory diagnosis that is not clear or perhaps incorrect. On the other hand, close and careful analysis of findings for a test battery consisting of objective procedures and behavioral tests whenever feasible usually leads to prompt and accurate diagnosis of auditory dysfunction. This paper provides a concise review of the crosscheck principle from its introduction to its clinical application today. The review concludes with a description of a modern test battery for pediatric hearing assessment that supplements traditional behavioral tests with a variety of independent objective procedures including aural immittance measures, otoacoustic emissions, and auditory evoked responses. PMID:27626077

  1. Big Data, the perfect instrument to study today's consumer behavior

    Directory of Open Access Journals (Sweden)

    Cristina STOICESCU

    2016-01-01

    Full Text Available Consumer behavior study is a new, interdisciplinary and emerging science, developed in the 1960s. Its main sources of information come from economics, psychology, sociology, anthropology and artificial intelligence. If a century ago, most people were living in small towns, with limited possibilities to leave their community, and few ways to satisfy their needs, now, due to the accelerated evolution of technology and the radical change of life style, consumers begin to have increasingly diverse needs. At the same time the instruments used to study their behavior have evolved, and today databases are included in consumer behavior research. Throughout time many models were developed, first in order to analyze, and later in order to predict the consumer behavior. As a result, the concept of Big Data developed, and by applying it now, companies are trying to understand and predict the behavior of their consumers.

  2. Burden of mortality in Greenland--today and tomorrow

    DEFF Research Database (Denmark)

    Nielsen, Lasse Christian; Hansen, Kristian Schultz; Nielsen, Ulla Ringgren

    2004-01-01

    : Concerted multi-sectoral approaches and broad holistic health strategies related to health promotion and prevention today will strategically improve the capability of the Greenlandic society to manage the future disease burden from ageing via its health care sector and the institutional sector for care......OBJECTIVES: Investigation of the relative impact of three factors expected to influence the future mortality burden in Greenland: demographic change, epidemiological transition and behavioural patterns. STUDY DESIGN: To identify general trends in public health status, evaluating the effect...... of public health campaigns and providing the basis for making predictions of future trends in the mortality burden data from the Greenlandic Death Causes Register to estimate Years of Life Lost (YLL) in the period 1976-1998 has been used. METHODS: YLL were estimated according to the Burden of Disease Method...

  3. Know Stroke: Know the Signs, Act in Time Video

    Medline Plus

    Full Text Available ... Announcer: Stroke touches so many American families. It's the 3rd leading cause of death and a leading cause of serious long-term disability. But today there is effective treatment that can prevent or reduce those disabilities. The key is - Know the Signs, Act in Time. ...

  4. Combinations of long acting β2 agonists to tiotropium: A randomized, double-blind, placebo-controlled, active-drug controlled, parallel design academic clinical trial in moderate COPD male patients

    Directory of Open Access Journals (Sweden)

    Mohammed Imran

    2015-01-01

    Conclusions: Study shows that tiotropium alone once a day is the evidence based and rationale pharmacotherapy in moderate COPD. There is no advantage or statistical significance of adding long acting β2 agonists (LABA such as formoterol to tiotropium either for 12 h (once daily or 24 h (twice daily.

  5. Nuclear Regulatory Authority Act, 2015 (Act 895)

    International Nuclear Information System (INIS)

    2015-04-01

    An Act to establish a Nuclear Regulatory Authority in Ghana. This Act provides for the regulation and management of activities and practices for the peaceful use of nuclear material or energy, and to provide for the protection of persons and the environment against the harmful effects of radiation; and to ensure the effective implementation of the country’s international obligations and for related matters. This Act replaced the Radiation Protection Instrument, of 1993 (LI 1559).

  6. Experiences from an ACT programme in Copenhagen

    DEFF Research Database (Denmark)

    Benjaminsen, Lars

    groups of ACT are individuals who have complex support needs due to for instance mental illness and/or substance abuse and for whom it is difficult to use mainstream support systems. The team consists not only of social support workers but also of a psychiatrist, a nurse and an addiction councilor......, and social workers with administrative authority from the social office and the job center. In the international research literature ACT has been shown in randomized controlled trials to be a very effective method in bringing individuals out of homelessness and into a stable housing situation. This study...... is based on quantitative outcome measurement in an intervention group of about 60 homeless individuals who through the program has received both a housing solution and support from the ACT-team. The study is not a randomized controlled trial as there is no control group. Furthermore qualitative interviews...

  7. Airway Clearance Techniques (ACTs)

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    Full Text Available ... CF continues to evolve as scientists study what causes the disease and how it affects the body. ... giving today. ANNUAL FUND Become a Corporate Supporter Cause Marketing Make a Charitable Gift Our Corporate Supporters ...

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    Full Text Available ... accredit more than 120 care centers and 53 affiliate programs nationwide. The high quality of specialized care ... today. ANNUAL FUND Become a Corporate Supporter Cause Marketing Make a Charitable Gift Our Corporate Supporters Workplace ...

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    Full Text Available ... today. ANNUAL FUND Become a Corporate Supporter Cause Marketing Make a Charitable Gift Our Corporate Supporters Workplace ... Board of Trustees Our Leadership Careers Reports and Financials Contact Us Governance and Policies What is CF? ...

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  19. Airway Clearance Techniques (ACTs)

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  20. Airway Clearance Techniques (ACTs)

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  3. Teenage Mothers Today: What We Know and How It Matters

    Science.gov (United States)

    Mollborn, Stefanie

    2016-01-01

    Over the past two decades, births to U.S. teenagers have fallen and no longer follow overall fertility patterns. Yet the unique challenges faced by teenage mothers and their families justify continued research. Across disciplines, newer work has furthered our understanding of teenage motherhood today. In this article, I highlight four areas of progress: processes of selection into teenage motherhood, the broader consequences of teenage childbearing beyond the socioeconomic realm, heterogeneity of effects, and the application of life course principles. Emerging societal trends such as complex family structures, a stalled recovery from the recession for families of low socioeconomic status, and a rapidly evolving political environment for reproductive health care continue to challenge the lives of teenage mothers. Given that the consequences for teenagers of becoming mothers may change, continued research is needed. Shifts in policy to favor supporting teenage mothers and addressing the causes of both teenage pregnancy and social disadvantage may help improve the lives of these mothers and their families. PMID:28533814

  4. Karl Marx and the Study of Media and Culture Today

    Directory of Open Access Journals (Sweden)

    Christian Fuchs

    2014-02-01

    Full Text Available The task of this paper discusses the role of Marx in analysing media, communica-tion and culture today. An analysis of three contemporary Cultural Studies works – Lawrence Grossberg’s monograph Cultural Studies in the Future Tense, John Hartley’s monograph Digital Futures for Cultural and Media Studies and Paul Smith’s edited volume The Renewal of Cultural Studies – shows that there is an agreement that the economy needs to be taken more into account by Cultural Studies, but disagreement on which approach should be taken and what the role of Karl Marx’s works shall be. The paper argues that Marx’s labour theory of value is especially important for critically analysing the media, culture and communica-tion. Labour is still a blind spot of the study of culture and the media, although this situation is slowly improving. It is maintained that the turn away from Marx in Cultural and Media Studies was a profound mistake that should be reverted. Only an engagement with Marx can make Cultural and Media Studies topical, politically relevant, practical and critical, in the current times of global crisis and resurgent critique.

  5. Critical Media and Communication Studies Today. A Conversation

    Directory of Open Access Journals (Sweden)

    Christian Fuchs

    2011-06-01

    Full Text Available This article documents a conversation between us that was first published in parallel on our two blogs http://dwmw.wordpress.com and http://fuchs.uti.at/blog. The conversation deals with our assessments of the status of Critical Media and Communication Studies today. We discuss the work of Dallas Smythe, how to study and assess Google, research dimensions of Critical Political Economy of the Media, how important each of these dimensions should be, the role of ideology critique for Critical Political Economy of the Media, the commonalities and differences between Political Economies of the Media and Critical Political Economy of the Media/Critique of the Political Economy of the Media, the role of Karl Marx for Political Economies of the Media, Nicholas Garnham's recent comments on the field of Critical Political Economy of the Media, neoliberalism and capitalist crisis as contexts for Political Economies of the Media. Comments are very welcome on our blogs, URLs to the specific blog postings can be found in the article sections.

  6. Anesthesia today with the economic and clinical aspects

    Directory of Open Access Journals (Sweden)

    Majstorović Branislava M.

    2016-01-01

    Full Text Available Introduction: The rapid development of knowledge and technology conditions the use of pharmacoeconomic and economic analysis in the system of market economy in health care. Pharmacoeconomics identifies, measures, compares and analyzes the relationship between costs and outcomes of the use of pharmaceutical products. Corresponding section headings: This review article, presents the results of our research in the field of hospital pharmacoeconomics in anesthesia in the Clinical Center of Serbia through published pharmacoeconomic studies from 2007 to today. In our years-long research we have given a description of the analysis of direct and indirect costs, assess the quality of treatment, efficiency and effectiveness to cost-benefit analysis of different techniques and types of anesthesia in the context of different surgical disciplines. Dispete The economic evaluation of medicines are increasingly important to medical authorities. Clinical pharmacology should be included as a way to rationally promote efficiency and effectiveness of the disease treatment. Conclusion: Economic and pharmacoeconomic assessments put emphasis on the quality of treatment and the potential gains for the public and individual patients. Probably the highest quality of medical services (the most effective drugs, enough staff, and new safer medical equipment showed as less expensive and have made the economic analysis more rational in the context of the total budget. More investment is creeper health.

  7. Nurses using futuristic technology in today's healthcare setting.

    Science.gov (United States)

    Wolf, Debra M; Kapadia, Amar; Kintzel, Jessie; Anton, Bonnie B

    2009-01-01

    Human computer interaction (HCI) equates nurses using voice assisted technology within a clinical setting to document patient care real time, retrieve patient information from care plans, and complete routine tasks. This is a reality currently utilized by clinicians today in acute and long term care settings. Voice assisted documentation provides hands & eyes free accurate documentation while enabling effective communication and task management. The speech technology increases the accuracy of documentation, while interfacing directly into the electronic health record (EHR). Using technology consisting of a light weight headset and small fist size wireless computer, verbal responses to easy to follow cues are converted into a database systems allowing staff to obtain individualized care status reports on demand. To further assist staff in their daily process, this innovative technology allows staff to send and receive pages as needed. This paper will discuss how leading edge and award winning technology is being integrated within the United States. Collaborative efforts between clinicians and analyst will be discussed reflecting the interactive design and build functionality. Features such as the system's voice responses and directed cues will be shared and how easily data can be documented, viewed and retrieved. Outcome data will be presented on how the technology impacted organization's quality outcomes, financial reimbursement, and employee's level of satisfaction.

  8. Financial Management in Children: Today Need, Tomorrow Necessity

    Directory of Open Access Journals (Sweden)

    Tooraj Sadeghi

    2015-05-01

    Full Text Available Nearly 80% of young people today will never be able to retire. Why? Because they lack the personal finance training that leads to long-term planning and future security. Connecting the dots between kids and money management skills prepares them for the financial realities the world will face over the next century. Pocket money is one of the first ways for children to learn the basics of managing money – a skill they’ll definitely need for life – and it makes children feel independent. Whether to give pocket money, and at what age, and how much to give are issues that often concern parents. There are many ways to handle this. To a large extent it depends on family values, practices and finances. The main reason for giving children pocket money is to help children learn to be able to manage money while they are still young and parents can guide them. It also may help children to feel that they are important members of the family, because they are given part of the family's spending money.

  9. [Childhood in flux--Part II: Modern times until today].

    Science.gov (United States)

    Hardt, Jochen; Hoffmann, Sven Olaf

    2006-01-01

    At the end of the 19th century, the Society for the Prevention of Cruelty to Children was founded in New York, after a barbarous case of neglect and abuse of a girl became public. From then on, children received more and more protection. Only in the 1950s were doctors in the USA bound by law to report cases of putative physical abuse to officials. In Sweden, physical punishment of children has been forbidden since 1989, and in Germany since 2001. The existence of sexual abuse of children had been a taboo subject for centuries, even though individual attempts to break that taboo were made--e. g., by S. Freud in the theory of seduction (Verführungstheorie). Only with the birth of the women's liberation movement in the early 1970s has public awareness arisen. Due to the work of J. Bowlby in the 1950s, it became clear that children of primates need more than air, water and food, namely a relationship between the child and an adult person (attachment). To what degree the basic needs of children are being fulfilled in Western societies today is still a controversial issue.

  10. Cardiological-interventional therapy of coronary artery disease today

    International Nuclear Information System (INIS)

    Reynen, K.; Henssge, R.

    1999-01-01

    The current importance of the interventional therapy of coronary artery disease may be deduced from the exponential increase in procedures performed in Germany in the last decade - at least 125,840 in 1996. Today, by improved catheter and balloon materials as well as by growing experience of the cardiologists, even complex lesions may be treated. Limitations of balloon angioplasty include acute vessel closure and restenosis - newer angioplasty devices like directional or rotational atherectomy or excimer-laser angioplasty did not overcome these limitations; only by coronary stenting, acute vessel closure could be managed and the likelihood of restenosis - at least in particular groups of patients - could be reduced. For a few years, intracoronary brachytherapy of the segments dilated with beta- or gamma-emitters has been seeking to reduce restenosis rate; the department of cardiology of the Dresden Cardiovascular Institute is participating in such a multicentre study using the beta-emitter 188 renium. Further main topics of our department represent primary angioplasty in patients with acute myocardial infarction and invasive diagnostic or interventional procedures by the transradial approach. (orig.)

  11. HOW UNIVERSAL ARE THE UNIVERSAL HUMAN RIGHTS TODAY?

    Directory of Open Access Journals (Sweden)

    Lia-Alexandra BALTADOR

    2016-12-01

    Full Text Available This paper aims to contribute to a constructive debate on human rights. The two World Wars of the last century brought about the creation of the United Nations aimed “to reaffirm faith in fundamental human rights, in the dignity and worth of the human person, in the equal rights of men and women and of nations large and small”. Only three years later the Universal Declaration of the Human Rights was elaborated and promoted by the UN, considered to be the foundation of international human rights law. Today, as globalization brings all closer together in a “global village”, one can see that there are many ways to perceive and guarantee human rights, in different states, but also within different states. Poverty, illiteracy, censorship, cruel treatment and even the lack of guarantee for the right to life are, unfortunately, the norm for many people of the world. Such observations bring up questions regarding the legitimacy, universality and coherence of human rights.

  12. U.S. bioremediation market: Yesterday, today, and tomorrow

    International Nuclear Information System (INIS)

    Devine, K.

    1995-01-01

    The use of bioremediation for full-scale cleanup has increased dramatically throughout the past 10 years. This growth in activity is expected to continue through the year 2000. It is estimated that fewer than 10 companies offered field-level bioremedial services prior to 1985. Although the market today still is dominated by a small number of companies, the total number of firms claiming to offer services and/or products for bioremediation purposes has grown to over 1,000. It is estimated that aggregate bioremediation revenues for 1994 through 2000 will equal $2 to $3 billion (1994 dollars). This revenue will be generated in the initial part of this 7-year period primarily from underground storage cleanup, with revenues from hazardous waste sites becoming an increasingly important factor by accounting for the majority of revenues in the latter years. Market opportunities exist in technology development and implementation including biosparging, centralized treatment facilities for petroleum-contaminated soils, biofilters, and improvements in the cost-effectiveness of the technology

  13. The power of data: structural bioinformatics yesterday and today

    KAUST Repository

    Tramontano, Anna

    2016-01-25

    The protein structure database was established in 1971. At the time it contained seven structures, today there are more than 100,000. The improvement is not only a matter of quantity, but also of quality. Did we effectively exploit this information to gain knowledge? The answer is certainly affirmative. I will illustrate how this wealth of experimental data has allowed us to explore the landscape of macromolecular structures on one side, and to uncover the properties of specific protein families on the other. The latter plays an essential role in pursuing exciting new avenues in biomedical and biotechnological sciences. Experimental data are also part of a virtuous cycle whereby they reinforce and guide our ability to infer unknown macromolecular structures, which, while providing relevant information to scientists, permits to gauge the level of our understanding of the complex problem of protein folding. A paradigmatic example of the latter is represented by the “Critical Assessment of Techniques for Protein Structure Prediction” (CASP) initiative that I will briefly discuss.

  14. Analytical difficulties facing today's regulatory laboratories: issues in method validation.

    Science.gov (United States)

    MacNeil, James D

    2012-08-01

    The challenges facing analytical laboratories today are not unlike those faced in the past, although both the degree of complexity and the rate of change have increased. Challenges such as development and maintenance of expertise, maintenance and up-dating of equipment, and the introduction of new test methods have always been familiar themes for analytical laboratories, but international guidelines for laboratories involved in the import and export testing of food require management of such changes in a context which includes quality assurance, accreditation, and method validation considerations. Decisions as to when a change in a method requires re-validation of the method or on the design of a validation scheme for a complex multi-residue method require a well-considered strategy, based on a current knowledge of international guidance documents and regulatory requirements, as well the laboratory's quality system requirements. Validation demonstrates that a method is 'fit for purpose', so the requirement for validation should be assessed in terms of the intended use of a method and, in the case of change or modification of a method, whether that change or modification may affect a previously validated performance characteristic. In general, method validation involves method scope, calibration-related parameters, method precision, and recovery. Any method change which may affect method scope or any performance parameters will require re-validation. Some typical situations involving change in methods are discussed and a decision process proposed for selection of appropriate validation measures. © 2012 John Wiley & Sons, Ltd.

  15. Interfaith education: A new model for today's interfaith families

    Science.gov (United States)

    Gordon, Sheila C.; Arenstein, Benjamin

    2017-04-01

    With societal changes rapidly transforming cultures that had been largely homogenous, today's multi-cultural - and in particular interfaith - families need new educational strategies to help them understand their cultural roots and identify and clarify what aspects of their heritages they wish to nurture and transmit to their children. This paper focuses on a new model for religious education, namely non-doctrinaire "dual-faith" education, which the principal author has helped to develop in the United States (US) through the Interfaith Community (IFC), a small, independent non-profit organisation created and led by dual-faith Jewish/Christian families. The model is premised on the notion that families can have two different faiths in one household and that - with respect and education - families can be harmonious, religion can be transmitted, and tolerance broadly nurtured. While the model is particular to the US and to families with Jewish and Christian heritages, its premises and structure have significant potential to be adaptable to other religious combinations and other cultures and countries. After reviewing relevant literature and situating the IFC model in the global and US contexts, the paper sets out to clarify the importance of the concept, describe its elements, and discuss its implications for religious education in this time of changing ethos and demography.

  16. What are today's choices for PWRs water chemistry?

    International Nuclear Information System (INIS)

    Berge, P.

    1998-01-01

    Water chemistry has always been, from the very beginning of operation of power Pressurized Water Reactors (PWRs), an important factor in determining the integrity of many reactor components. For both the primary and secondary coolant circuits, the parameters to control the quality of the chemistry have been subject to changes in time. These changes were dictated mainly by corrosion problems which required an adjustment of the chemistry, before any modification could be made in the design or the selection of materials for the subsequently built reactors or replacement components. The situation today, despite 40 years of experience, still leaves open different options for the specifications of the chemistry of the circuits. These options are sometimes due to differences in design or materials of the circuits, but more often, to the perception by the plant chemists, of the role of the chemistry on the different phenomena which could affect the operation of their plant. Paul Cohen, who was well known in the nuclear industry for the early development of the chemistry in PWRs in the USA, used to say, 'if the head chemist has changed in a plant, the chemistry will change'. The purpose of this lecture is to discuss some of the options which are offered to the chemist in compliance with the basic principles of the chemistry guidelines. (J.P.N.)

  17. Atomic Act amended

    International Nuclear Information System (INIS)

    Drabova, D.

    2002-01-01

    In the paper by the chairwoman of the Czech nuclear regulatory authority, the history of Czech nuclear legislation is outlined, the reasons for the amendment of the Atomic Act (Act No. 18/1997) are explained, and the amendments themselves are highlighted. The Act No. 13/2002 of 18 December 2001 is reproduced from the official Collection of Acts of the Czech Republic in the facsimile form. The following acts were thereby amended: Atomic Act No. 18/1997, Metrology Act No. 505/1990, Public Health Protection Act No. 258/2000, and Act No. 2/1969 on the Establishment of Ministries and Other Governmental Agencies of the Czech Republic. (P.A.)

  18. Clinical Trials

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  19. Clinical Trials

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    Full Text Available ... groups, companies, and organizations also sponsor clinical trials. Examples include Government Agencies, such as the U.S. Departments ... sponsor trials that test principles or strategies. For example, one NHLBI study explored whether the benefits of ...

  20. Clinical Trials

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    Full Text Available ... Departments of Defense and Veterans Affairs; private companies; universities; and nonprofit organizations. NIH Institutes and Centers (including ... our campus or trials NIH has sponsored at universities, medical centers, and hospitals. ClinicalTrials.gov View a ...

  1. Clinical Trials

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    Full Text Available ... Entire Site NHLBI Entire Site Health Topics News & Resources Intramural Research ... or device is safe and effective for humans. What Are Clinical Trials? Clinical trials are research ...

  2. Clinical Trials

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    Full Text Available ... sponsor clinical trials. Many other groups, companies, and organizations also sponsor clinical trials. Examples include Government Agencies, ... and Veterans Affairs; private companies; universities; and nonprofit organizations. NIH Institutes and Centers (including the NHLBI) usually ...

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    Full Text Available ... decisionmaking. The purpose of clinical trials is research, so the studies follow strict scientific standards. These standards ... otherwise. The purpose of clinical trials is research, so the studies follow strict scientific standards. These standards ...

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    Full Text Available ... identified earlier than they would be in general medical practice. This is because late-phase trials have large ... supporting clinical trials that have not only shaped medical practice around the world, but have improved the health ...

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    Full Text Available ... risks that outweigh any possible benefits. Clinical Trial Phases Clinical trials of new medicines or medical devices are done in phases. These phases have different purposes and help researchers ...

  17. Clinical Trials

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    Full Text Available ... the past, clinical trial participants often were White men. Researchers assumed that trial results were valid for ... different ethnic groups sometimes respond differently than White men to the same medical approach. As a result, ...

  18. Clinical Trials

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    Full Text Available ... clinical trials. An IRB is an independent committee created by the institution that sponsors a clinical trial. ... have not only shaped medical practice around the world, but have improved the health of millions of ...

  19. Clinical Trials

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    Full Text Available ... or strategies work best for certain illnesses or groups of people. Some clinical trials show a positive result. For example, the National Heart, Lung, and Blood Institute (NHLBI) sponsored a trial of two different ...

  20. Clinical Trials

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    Full Text Available ... and Centers sponsor clinical trials. Many other groups, companies, and organizations also sponsor clinical trials. Examples include ... U.S. Departments of Defense and Veterans Affairs; private companies; universities; and nonprofit organizations. NIH Institutes and Centers ( ...

  1. Clinical Trials

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    Full Text Available ... for trials with cutting-edge approaches, such as gene therapy or new biological treatments. Health insurance and ... trials that involve high-risk procedures (such as gene therapy) or vulnerable patients (such as children). A ...

  2. Clinical Trials

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    Full Text Available ... comparison groups by chance, rather than choice. This method helps ensure that any differences observed during a ... to learn more about clinical research and to search for clinical trials: NHLBI Clinical Trials Browse a ...

  3. Clinical Trials

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    Full Text Available ... healthy people to test new approaches to prevention, diagnosis, or screening. In the past, clinical trial participants ... DSMBs for large trials comparing alternative strategies for diagnosis or treatment. In addition, the NIH requires DSMBs ...

  4. Clinical Trials

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    Full Text Available ... at the smallest dose and for the shortest time possible. Clinical trials, like the two described above, ... in a clinical trial, find out ahead of time about costs and coverage. You should learn about ...

  5. Clinical Trials

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    Full Text Available ... Clinical trials produce the best data available for health care decisionmaking. The purpose of clinical trials is research, ... and advance medical care. They also can help health care decisionmakers direct resources to the strategies and treatments ...

  6. Clinical Trials

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    Full Text Available ... whether a new approach causes any harm. In later phases of clinical trials, researchers learn more about ... other National Institutes of Health (NIH) Institutes and Centers sponsor clinical trials. Many other groups, companies, and ...

  7. Clinical Trials

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    Full Text Available ... are research studies that explore whether a medical strategy, treatment, or device is safe and effective for ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ...

  8. Clinical Trials

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    Full Text Available ... treatment, or device is safe and effective for humans. What Are Clinical Trials? Clinical trials are research ... are required to have an IRB. Office for Human Research Protections The U.S. Department of Health and ...

  9. Clinical Trials

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    Full Text Available ... these results are important because they advance medical knowledge and help improve patient care. Sponsorship and Funding ... All types of clinical trials contribute to medical knowledge and practice. Why Clinical Trials Are Important Clinical ...

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    Full Text Available ... well they work. The U.S. Food and Drug Administration (FDA) oversees these clinical trials. The NIH may partner with these companies or groups to help sponsor some trials. All ...

  11. Clinical Trials

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    Full Text Available ... best data available for health care decisionmaking. The purpose of clinical trials is research, so the studies ... Thus, research in humans is needed. For safety purposes, clinical trials start with small groups of patients ...

  12. Clinical Trials

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    Full Text Available ... trials produce the best data available for health care decisionmaking. The purpose of clinical trials is research, ... they advance medical knowledge and help improve patient care. Sponsorship and Funding The National Heart, Lung, and ...

  13. Clinical Trials

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    Full Text Available ... Events About NHLBI About NHLBI Home Mission and Strategic Vision Leadership Scientific Divisions Operations and Administration Advisory ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ...

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    Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... Customer Service/Center for Health Information Email Alerts Jobs and Careers Site Index About NHLBI National Institute ...

  15. Clinical Trials

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    Full Text Available ... Some companies and groups sponsor clinical trials that test the safety of products, such as medicines, and how well they work. The U.S. Food and Drug Administration (FDA) oversees these clinical trials. ...

  16. Clinical Trials

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    Full Text Available ... What to Expect During a clinical trial, doctors, nurses, social workers, and other health care providers might ... enroll in a clinical trial, a doctor or nurse will give you an informed consent form that ...

  17. Clinical Trials

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    Full Text Available ... and doctors' offices around the country. Benefits and Risks Possible Benefits Taking part in a clinical trial ... volunteer because they want to help others. Possible Risks Clinical trials do have risks and some downsides, ...

  18. Clinical Trials

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    Full Text Available ... sponsored a trial of two different combinations of asthma treatments. The trial found that one of the ... much better than the other for moderate persistent asthma. The results provided important treatment information for doctors ...

  19. Clinical Trials

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    Full Text Available ... Sponsors also may stop a trial, or part of a trial, early if the strategy or treatment is having harmful effects. Food and Drug Administration In the United States, the Food and Drug Administration (FDA) provides oversight ...

  20. Clinical Trials

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    Full Text Available ... providers don't always cover all patient care costs for clinical trials. If you're thinking about ... clinical trial, find out ahead of time about costs and coverage. You should learn about the risks ...

  1. Clinical Trials

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    Full Text Available ... including the NHLBI) usually sponsor trials that test principles or strategies. For example, one NHLBI study explored ... risks. Other examples of clinical trials that test principles or strategies include studies that explore whether surgery ...

  2. Clinical Trials

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    Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... your doctor about all of your treatment options. Together, you can make the best choice for you. ...

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    Full Text Available ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ... Customer Service/Center for Health Information Email Alerts Jobs and Careers Site Index About NHLBI National Institute ...

  4. Surgical management of peptic ulcer disease today--indication, technique and outcome.

    Science.gov (United States)

    Zittel, T T; Jehle, E C; Becker, H D

    2000-03-01

    The current surgical management of peptic ulcer disease and its outcome have been reviewed. Today, surgery for peptic ulcer disease is largely restricted to the treatment of complications. In peptic ulcer perforation, a conservative treatment trial can be given in selected cases. If laparotomy is necessary, simple closure is sufficient in the large majority of cases, and definitive ulcer surgery to reduce gastric acid secretion is no longer justified in these patients. Laparoscopic surgery for perforated peptic ulcer has failed to prove to be a significant advantage over open surgery. In bleeding peptic ulcers, definitive hemostasis can be achieved by endoscopic treatment in more than 90% of cases. In 1-2% of cases, immediate emergency surgery is necessary. Some ulcers have a high risk of re-bleeding, and early elective surgery might be advisable. Surgical bleeding control can be achieved by direct suture and extraluminal ligation of the gastroduodenal artery or by gastric resection. Benign gastric outlet obstruction can be controlled by endoscopic balloon dilatation in 70% of cases, but gastrojejunostomy or gastric resection are necessary in about 30% of cases. Elective surgery for peptic ulcer disease has been largely abandoned, and bleeding or obstructing ulcers can be managed safely by endoscopic treatment in most cases. However, surgeons will continue to encounter patients with peptic ulcer disease for emergency surgery. Currently, laparoscopic surgery has no proven advantage in peptic ulcer surgery.

  5. Current knowledge and trends in age-related macular degeneration: today's and future treatments.

    Science.gov (United States)

    Velez-Montoya, Raul; Oliver, Scott C N; Olson, Jeffrey L; Fine, Stuart L; Mandava, Naresh; Quiroz-Mercado, Hugo

    2013-09-01

    To address the most dynamic and current issues concerning today's treatment options and promising research efforts regarding treatment for age-related macular degeneration. This review is aimed to serve as a practical reference for more in-depth reviews on the subject. An online review of the database PubMed and Ovid were performed, searching for the key words age-related macular degeneration, AMD, VEGF, treatment, PDT, steroids, bevacizumab, ranibizumab, VEGF-trap, radiation, combined therapy, as well as their compound phrases. The search was limited to articles published since 1985. All returned articles were carefully screened, and their references were manually reviewed for additional relevant data. The web page www.clinicaltrials.gov was also accessed in search of relevant research trials. A total of 363 articles were reviewed, including 64 additional articles extracted from the references. At the end, only 160 references were included in this review. Treatment for age-related macular degeneration is a very dynamic research field. While current treatments are mainly aimed at blocking vascular endothelial growth factor, future treatments seek to prevent vision loss because of scarring. Promising efforts have been made to address the dry form of the disease, which has lacked effective treatment.

  6. Airway Clearance Techniques (ACTs)

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    Full Text Available ... in CF Clinical Care Guidelines Cystic Fibrosis-Related Diabetes Clinical Care Guidelines Liver Disease Clinical Care Guidelines ... improve the treatment of cystic fibrosis. CFTR Modulator Types Clinical Trials Clinical Trials 101 What to Consider ...

  7. Airway Clearance Techniques (ACTs)

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    Full Text Available ... cystic fibrosis comes with many challenges, including medical, social, and financial. By learning more about how you ... Huffing High-Frequency Chest Wall Oscillation Positive Expiratory Pressure Clinical Trials Clinical Trials 101 What to Consider ...

  8. Airway Clearance Techniques (ACTs)

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    Full Text Available ... Series Find Out More About Your Mutations Personalized Medicine Types of CFTR Mutations DIAGNOSIS If you or ... the Clinical Trial: What’s Next? CLINICAL TRIAL FINDER DRUG DEVELOPMENT PIPELINE Drug Development Pipeline 101 About the ...

  9. Airway Clearance Techniques (ACTs)

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    Full Text Available ... the Clinical Trial: What’s Next? CLINICAL TRIAL FINDER DRUG DEVELOPMENT PIPELINE Drug Development Pipeline 101 About the Drug Development Pipeline How Drugs Get on the Pipeline ...

  10. Airway Clearance Techniques (ACTs)

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    Full Text Available ... Dr. William Skach Paul di Sant’Agnese Distinguished Scientific Achievement Award Quality Care Awards Richard C Talamo ... clinical trial that may be right for you. Search Trials CFF Homepage Cystic Fibrosis Foundation 4550 Montgomery ...

  11. Airway Clearance Techniques (ACTs)

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    Full Text Available ... Clinician Career Development Awards Clinician Training Awards Mutation Analysis Program Network News Network News: March 2018 Network ... the Clinical Trial: What’s Next? CLINICAL TRIAL FINDER DRUG DEVELOPMENT PIPELINE Drug Development Pipeline 101 About the ...

  12. Airway Clearance Techniques (ACTs)

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    Full Text Available ... Physical Therapy Coughing and Huffing High-Frequency Chest Wall Oscillation Positive Expiratory Pressure Clinical Trials Clinical Trials ... clapping) or vibration to loosen mucus from airway walls. See how different airway clearance techniques work to ...

  13. Airway Clearance Techniques (ACTs)

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    Full Text Available ... improve the treatment of cystic fibrosis. CFTR Modulator Types Clinical Trials Clinical Trials 101 What to Consider ... Find Out More About Your Mutations Personalized Medicine Types of CFTR Mutations Researcher Resources Researchers, supported by ...

  14. Airway Clearance Techniques (ACTs)

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    Full Text Available ... Insurance Coverage and Open Enrollment Periods Claims and Appeals Glossary of Common Health Insurance Terms Understanding Travel ... improve the treatment of cystic fibrosis. CFTR Modulator Types Clinical Trials Clinical Trials 101 What to Consider ...

  15. Airway Clearance Techniques (ACTs)

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    Full Text Available ... Parenting With CF Making Your Family Planning Decisions Pregnancy and CF Alternative Ways to Build a Family ... the Clinical Trial: What’s Next? CLINICAL TRIAL FINDER DRUG DEVELOPMENT PIPELINE Drug Development Pipeline 101 About the ...

  16. Latin American Integration: Yesterday, Today and Perhaps Tomorrow

    Directory of Open Access Journals (Sweden)

    Flavio Alves Soares

    1992-12-01

    Full Text Available This paper aims to analyse, more subjectively than objectively, the development of ALALC-ALADI and to show the path for the MERCOSUR. The author evaluates the successes and failures of ALALC-ALADI -the first two attempts of regional economic concentration- focusing his attention on ALADI, being this more recent and with the aim of acting as an integrationist regional frame. About the MERCOSUR, the author remarks the potential involved in the bilateral trade between Brazil and Argentine, which can be the origin of the construction of Common Market of the South, with Paraguay's and Uruguay's participation.

  17. The Role of the Right Hemisphere in Speech Act Comprehension

    Science.gov (United States)

    Holtgraves, Thomas

    2012-01-01

    In this research the role of the RH in the comprehension of speech acts (or illocutionary force) was examined. Two split-screen experiments were conducted in which participants made lexical decisions for lateralized targets after reading a brief conversation remark. On one-half of the trials the target word named the speech act performed with the…

  18. Clinical Trials

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    Full Text Available ... resources to the strategies and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, you may get tests or treatments in a hospital, clinic, or doctor's office. In some ways, taking part in a clinical trial is different ...

  19. Clinical Trials

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    Full Text Available ... Health Topics / About Clinical Trials About Clinical Trials Clinical trials are research studies that explore whether a medical strategy, treatment, ... tool for advancing medical knowledge and patient care. Clinical research is done only if doctors don't know ...

  20. Clinical Trials

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    Full Text Available ... about your health or fill out forms about how you feel. Some people will need to travel or stay in hospitals to take part in clinical trials. For example, the National Institutes of Health Clinical Center in Bethesda, Maryland, runs clinical trials. Many other clinical trials take place ...

  1. Clinical Trials

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    Full Text Available ... more screening tests to see which test produces the best results. Some companies and groups sponsor clinical trials that test the ... and Drug Administration (FDA) oversees these clinical trials. The NIH may partner with these companies or groups to help sponsor some trials. All ...

  2. Clinical Trials

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    Full Text Available ... child to enroll. Also, children aged 7 and older often must agree (assent) to take part in clinical trials. Clinical trials for children have the same scientific safeguards as clinical trials for adults. For more information, go to "How Do Clinical ...

  3. Clinical Trials

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    Full Text Available ... give permission for their child to enroll. Also, children aged 7 and older often must agree (assent) to take part in clinical trials. Find a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ...

  4. Clinical Trials

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    Full Text Available ... part in a clinical trial is your decision. Talk with your doctor about all of your treatment options. Together, you can make the ... more about, or taking part in, clinical trials, talk with your doctor. He or she may know about ... clinical trials. NIH Clinical Research Studies ...

  5. Prevention of Malnutrition in Children, Slimming Yesterday, Obesity Today

    Directory of Open Access Journals (Sweden)

    S Sharafi

    2014-04-01

    Full Text Available Introduction: The future of any nation depends on how its children's care, According to their likely future health needs of the adult population model for healthy living and wealth has increased. One of the most pressing health diet. This study is done to aimed investigate the factors influencing malnutrition in children in the past for weight loss and weight gain can be seen today.   Methods and Methods: Related articles referring to achieve in the field of databases to Google scholar, Pub Med, proquest, SID, Magiran, Springer Link,… and studies until 2013 with the key words malnutrition, child, obesity and examine their English.   Results: In the past, malnutrition was associated with weight loss, but for now he has to weight gain and obesity. Childhood obesity is emerging as a phenomenon caused health problems in childhood and adolescence, including hyperlipidemia, obstructive sleep apnea, early puberty, diabetes, hypertension and cardiovascular. In addition to the health problems of obese children will benefit from the social and psychological problems such as anxiety, fewer friends, loss of confidence, lower education, and fewer chances for marriage.... Overweight in children can be caused by poor eating habits and low activity, which is affected by the parents and the family environment.   Conclusions: Since the patterns learned in childhood affect all life on lifestyle, understand the causes of obesity and to eliminate or reduce them and reinforce the correct patterns of feeding Through education and the incidence is somewhat reduced, especially for parents to deal with this phenomenon.   Keywords: Child,Malnutrition, Obesity    

  6. The ultimately accountable job: leading today's sales organization.

    Science.gov (United States)

    Colletti, Jerome A; Fiss, Mary S

    2006-01-01

    In recent years, sales leaders have had to devote considerable time and energy to establishing and maintaining disciplined processes. The thing is, many of them stop there--and they can't afford to, because the business environment has changed. Customers have gained power and gone global, channels have proliferated, more product companies are selling services, and many suppliers have begun providing a single point of contact for customers. Such changes require today's sales leaders to fill various new roles: Company leader. The best sales chiefs actively help formulate and execute company strategy, and they collaborate with all functions of the business to deliver value to customers. Customer champion. Customers want C-level relationships with suppliers in order to understand product strategy, look at offerings in advance, and participate in decisions made about future products--and sales leaders are in the best position to offer that kind of contact. Process guru. Although sales chiefs must look beyond the sales and customer processes they have honed over the past decade, they can't abandon them. The focus on process has become only more important as many organizations have begun bundling products and services to meet important customers' individual needs. Organization architect. Good sales leaders spend a lot of time evaluating and occasionally redesigning the sales organization's structure to ensure that it supports corporate strategy. Often, this involves finding the right balance between specialized and generalized sales roles. Course corrector. Sales leaders must watch the horizon, but they can't take their hands off the levers or forget about the dials. If they do, they might fail to respond when quick adjustments in priorities are needed.

  7. DEVELOPMENT OF MIGRATION POTENTIAL IN HUNGARY FROM 2000 UNTIL TODAY

    Directory of Open Access Journals (Sweden)

    Margit Csipkés

    2018-03-01

    Full Text Available Hearing the words “international migration”, two things might come to our mind. One of them is the emigration process and the other is the wave of refugees. In our study, we examined the changes of the number of employees emigrating from Hungary from 2000 until today. Nowadays, the examination of the migration potential is an important topic in Hungary, since the rate of Hungarian emigrants started to grow after 2006 and the rate of growth became even faster after 2010. The reason of the acceleration was the opening of the Austrian and German labour market. The actuality of the topic is based on the fact that international emigration merges the labour market’s processes, influences the given country’s employment level, moreover it has an influencing role on the rate of wages. Emigration from a given state has several reasons: natural disasters, war, marginalization, economic reasons, etc. In our study, we examine emigration caused by economic reasons. We have to take into consideration that measuring emigration processes is a difficult task, due to the lack of data. The reason of the deficiency is that those who leave the country, often forget to report their leaving. From 1 March 2013, only the permanent foreign settlement should be reported towards the administration (District Office, Consulate. Earlier, temporary (more than 3 months settlement was also obligatory to be reported. Many of the leaving Hungarians do not report their leaving, however working abroad for more than 3 months should be reported towards social insurance organizations and tax authorities. I would like to emphasise that my migration potential presentation does not show a direct correlation with the actual migration. However, this study might show the expected movement rates and the composition of emigrants.

  8. Undergraduate Biocuration: Developing Tomorrow's Researchers While Mining Today's Data.

    Science.gov (United States)

    Mitchell, Cassie S; Cates, Ashlyn; Kim, Renaid B; Hollinger, Sabrina K

    2015-01-01

    Biocuration is a time-intensive process that involves extraction, transcription, and organization of biological or clinical data from disjointed data sets into a user-friendly database. Curated data is subsequently used primarily for text mining or informatics analysis (bioinformatics, neuroinformatics, health informatics, etc.) and secondarily as a researcher resource. Biocuration is traditionally considered a Ph.D. level task, but a massive shortage of curators to consolidate the ever-mounting biomedical "big data" opens the possibility of utilizing biocuration as a means to mine today's data while teaching students skill sets they can utilize in any career. By developing a biocuration assembly line of simplified and compartmentalized tasks, we have enabled biocuration to be effectively performed by a hierarchy of undergraduate students. We summarize the necessary physical resources, process for establishing a data path, biocuration workflow, and undergraduate hierarchy of curation, technical, information technology (IT), quality control and managerial positions. We detail the undergraduate application and training processes and give detailed job descriptions for each position on the assembly line. We present case studies of neuropathology curation performed entirely by undergraduates, namely the construction of experimental databases of Amyotrophic Lateral Sclerosis (ALS) transgenic mouse models and clinical data from ALS patient records. Our results reveal undergraduate biocuration is scalable for a group of 8-50+ with relatively minimal required resources. Moreover, with average accuracy rates greater than 98.8%, undergraduate biocurators are equivalently accurate to their professional counterparts. Initial training to be completely proficient at the entry-level takes about five weeks with a minimal student time commitment of four hours/week.

  9. Cda Science Today and in Cassini's Final Three Years

    Science.gov (United States)

    Srama, R.

    2014-12-01

    Today, the German-lead Cosmic Dust Analyser (CDA) is operated continuously for 10 years in orbit around Saturn. The first discovery of CDA related to Saturn was the measurement of nanometer sized dust particles ejected by to interplanetary space with speeds higher than 100 km/s. Their origin and composition was analysed and and their dynamical studies showed a strong link to the conditions of the solar wind plasma flow. A recent surprising result was, that stream particles stem from the interior of Enceladus. Since 2004 CDA measured millions of dust impacts characterizing the dust environment of Saturn. The instrument showed strong evidence for ice geysers located at the south pole of Saturn's moon Enceladus in 2005. Later, a detailed compositional analysis of the salt-rich water ice grains in Saturn's E ring system lead to the discovery of liquid water below the icy crust connected to an ocean at depth feeding the icy jets. CDA was even capable to derive a spatially resolved compositional profile of the plume during close Enceladus flybys. A determination of the dust-magnetosphere interaction and the discovery of the extended E ring allowed the definition of a dynamical dust model of Saturn's E ring describing the observed properties. The measured dust density profiles in the dense E ring revealed geometric asymmetries.In the final three years CDA performs exogenous and interstellar dust campaigns, studies of the composition and origin of Saturn's main rings by unique ring ejecta measurements, long-duration nano-dust stream observations, high-resolution maps of small moon orbit crossings, studies of the dust cloud around Dione and studies of the E-ring interaction with the large moon Titan.

  10. Effects of a long-acting formulation of octreotide on renal function and renal sodium handling in cirrhotic patients with portal hypertension: a randomized, double-blind, controlled trial

    DEFF Research Database (Denmark)

    Ottesen, L.H.; Aagaard, Niels Kristian; Kiszka-Kanowitz, M.

    2001-01-01

    variable effects. Twenty-five cirrhotic patients with portal hypertension were randomized in a double-blind design to placebo or a single subcutaneous dose of a long-acting formulation of octreotide (octreotide-LAR) (20 mg). Renal function tests were performed before dosing and repeated after 30 days...... with octreotide-LAR. It is concluded that in spite of increased arterial pressure, octreotide-LAR has no significant effect on renal hemodynamics and tubular function in clinically stable cirrhotic patients with portal hypertension....

  11. Clinical Trials

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    Full Text Available ... With Us Contact Us Directly Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility Copyright and Usage ... across the Institute. Learn More Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility Copyright and Usage ...

  12. Clinical Trials

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    Full Text Available ... Rights The informed consent document is not a contract. You have the right to withdraw from a ... Us Directly Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility Copyright and Usage No FEAR Act ...

  13. Clinical Trials

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    Full Text Available ... Learn More Connect With Us Contact Us Directly Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility ... and highlights from across the Institute. Learn More Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility ...

  14. Clinical Trials

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    Full Text Available ... More Connect With Us Contact Us Directly Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility Copyright ... highlights from across the Institute. Learn More Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility Copyright ...

  15. Airway Clearance Techniques (ACTs)

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    Full Text Available ... Therapeutics Lab Developing New Treatments The CF Foundation offers a number of resources for learning about clinical ... her father: Demonstrate and discuss common ACT therapies Offer their tips for fitting ACTs into daily life ...

  16. Airway Clearance Techniques (ACTs)

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    Full Text Available ... Treatments and Therapies Airway Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your airways. ... or caregiver. Older kids and adults can choose ACTs that they can do on their own. Share ...

  17. Odor and the Clean Air Act

    International Nuclear Information System (INIS)

    Morse, H.N.

    1993-01-01

    The case described in this paper involves the interpretation of language contained in the Texas Clean Air Act Texas Health and Safety Code Ann. Sections 382.001-382.141. The State of Texas, on behalf of the Texas Air Control Board, brought suit in the District Court of Erath County, Texas against the F/R Cattle Company, Inc., alleging that, because of odors emanating from the company's cattle feeding facility, the company was violating the Clean Air Act. The Board is granted the power and duty to administer the Clean Air Act and is directed to accomplish the purposes of the Act through the control of air contaminants by all practical and economically feasible methods. Described here is the evidence presented at and proceedings of the trial

  18. Nuclear Installations Act 1965

    International Nuclear Information System (INIS)

    1965-01-01

    This Act governs all activities related to nuclear installations in the United Kingdom. It provides for the licensing procedure for nuclear installations, the duties of licensees, the competent authorities and carriers of nuclear material in respect of nuclear occurrences, as well as for the system of third party liability and compensation for nuclear damage. The Act repeals the Nuclear Installations (Licensing and Insurance) Act 1959 and the Nuclear Installations (Amendment Act) 1965 except for its Section 17(2). (NEA) [fr

  19. Massive stars and miniature robots: today's research and tomorrow's technologies

    Science.gov (United States)

    Taylor, William David

    2013-03-01

    number of the potential future tests, and avenues for new research, are discussed. This is a thesis that brings together an area of active astronomical research with cutting-edge technological development, highlighting how tomorrow's telescopes will be an essential tool to answer some of today's most puzzling research questions

  20. Nodule detection in digital chest radiography: Summary of the radius chest trial

    International Nuclear Information System (INIS)

    Haakansson, M.; Baath, M.; Boerjesson, S.; Kheddache, S.; Grahn, A.; Ruschin, M.; Tingberg, A.; Mattson, S.; Maansson, L. G.

    2005-01-01

    As a part of the Europe-wide research project 'Unification of physical and clinical requirements for medical X-ray imaging' - governed by the Radiological Imaging Unification Strategies (RADIUS) Group - a major image quality trial was conducted by members of the group. The RADIUS chest trial aimed at thoroughly examining various aspects of nodule detection in digital chest radiography, such as the effects of nodule location, system noise, anatomical noise, and anatomical background. The main findings of the RADIUS chest trial concerning the detection of a lung nodule with a size in the order of 10 mm can be summarised as: (1) the detectability of the nodule is largely dependent on its location in the chest, (2) the system noise has a minor impact on the detectability at the dose levels used today, (3) the disturbance of the anatomical noise is larger than that of the system noise but smaller than that of the anatomical background and (4) the anatomical background acts as noise to a large extent and is the major image component affecting the detectability of the nodule. (authors)

  1. Nodule detection in digital chest radiography: Introduction to the radius chest trial

    International Nuclear Information System (INIS)

    Baath, M.; Haakansson, M.; Boerjesson, S.; Kheddache, S.; Grahn, A.; Ruschin, M.; Tingberg, A.; Mattsson, S.; Maansson, L. G.

    2005-01-01

    Most digital radiographic systems of today have wide latitude and are hence able to provide images with a small constraint on dose level. This opens up for an unprejudiced dose optimisation. However, in order to succeed in the optimisation task, good knowledge of the imaging and detection processes is needed. As a part of the European-wide research project 'unification of physical and clinical requirements for medical X-ray imaging - governed by the Radiological Imaging Unification Strategies (RADIUS) Group - a major image quality trial was conducted by members of the group. The RADIUS chest trial was focused on the detection of lung nodules in digital chest radiography with the aims of determining to what extent (1) the detection of a nodule is dependent on its location, (2) the system noise disturbs the detection of lung nodules, (3) the anatomical noise disturbs the detection of lung nodules and (4) the image background and anatomical background act as pure noise for the detection of lung nodules. The purpose of the present paper is to give an introduction to the trial and describe the framework and set-up of the investigation. (authors)

  2. Effect on motivation, perceived competence, and activation after participation in the ''Ready to Act'' programme for people with screen-detected dysglycaemia: a 1-year randomised controlled trial, Addition-DK.

    Science.gov (United States)

    Maindal, Helle Terkildsen; Sandbæk, Annelli; Kirkevold, Marit; Lauritzen, Torsten

    2011-05-01

    To investigate the reach of the ''Ready to Act'' programme and the 1-year effects on psychological determinants of healthy behaviour: motivation, perceived competence, and activation level. A total of 509 adults with dysglycaemia were recruited from general practioners (GPs) in the intensive arm of the Danish Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION) study, a type 2 diabetes screening programme. The participants were randomised to the ''Ready to Act'' programme added on top of GP care (n = 322) or to GP care (n = 187). The core components of the programme were motivation, action experience, informed decision-making, and social involvement conducted in two one-to-one sessions and eight group-meetings (18 hours). The reach of the programme was measured by the proportion of people who signed up. Outcomes were changes in treatment motivation (Treatment Self-Regulation Questionnaire, TSRQ), perceived competence (Perceived Competence Scale, PCS), and activation in chronic care (Patient Activation Measure, PAM). Effect size was the difference between 1-year changes in the randomisation groups analysed by intention-to-treat. A total of 142 (44%) of 322 signed up and 123 (87%) of these completed. At 1 year, the difference in autonomous motivation for behavioural treatment (TSRQ) between the randomisation groups was 1.0 (95% CI 0.1 to 2.0), and the difference in perceived competence changes in healthy diet (PCS-d) was 1.5 (95% CI 0.2 to 2.7). No differences were observed for activation (PAM) between the groups. Subgroup analysis revealed men to benefit more from the intervention than women. The programme is a promising health-promoting component in prevention and care for people with screen-detected dysglycaemia, as it attracted four of 10 people and had effects on motivation and perceived competence.

  3. Act local, think global

    International Nuclear Information System (INIS)

    Lewis, Chris; McRoberts, Doug

    2002-01-01

    Tip O'Neill, one of the grand old men of modem US politics, once famously remarked that all politics is local. Like most politicians who succeed on the national stage - and not just in the US - it was a truth he never lost sight of. What is true for politicians is equally true in the communications business. We may increasingly live in a global village, but successful companies - even multi-nationals - forget the importance of local and regional public relations at their peril. Think of Douglas Ivester, the CEO of Coca-Cola at the time of the 1999 Belgian contamination scandal, who allegedly reacted to first reports of the crisis by asking: 'Where the hell is Belgium?' A more appropriate question today - several years after Coke's share price toppled and the CEO was unceremoniously sacked - might be: 'Who the hell is Douglas Nester?' But - to adapt another famous phrase - the fact that communications (and marketing) professionals still need to 'act local' as much as ever before should not blind us to the growing need to 'think global'. In the nuclear industry, as in the world economy generally, increasing global integration is a reality, as are the international nature of the news media and the increasingly global nature of the anti-nuclear pressure groups. Indeed, it was the growing need for a truly global information network to counter these trends, by increasing the overall speed and accuracy of the worldwide nuclear information flow, that led the nuclear community to establish NucNet in 1991. So where exactly is the line between local and regional nuclear communications on the one hand, and global communications on the other? Is there one spin for a regional audience, and another for a global audience? This presentation proposes some guiding principles, by examining the response of nuclear communicators world-wide to the new communications agenda imposed in the wake of the September 11th suicide attacks in the US. NucNet President Doug McRoberts and Executive

  4. Challenging today's nuclear industry to be competitive in a changing tomorrow

    International Nuclear Information System (INIS)

    Plug, B.

    1996-01-01

    As the millennium approaches, the future of the nuclear power generation appears desolate. Today's nuclear executives are facing challenges resulting from worldwide change and have forced utilities to reevaluate their corporation's future directions. The nuclear industry must be competitive more than ever to address today's rapid changing marketplace and pressures exerted from: regulatory reformation; increased competition; changes in technology; customer evolution; and globalization. These factors have compelled nuclear executives to address questions such as: What impact will these changes have on today's marketplace, and on my corporation? What will characterize tomorrow's successful nuclear facility? How can today's nuclear corporation compete in tomorrow's marketplace? Will my corporation survive? (author)

  5. Long acting injectable hormonal contraceptives.

    Science.gov (United States)

    Fraser, I S

    1982-03-01

    Injectable hormonal preparations can be highly effective and satisfactory contraceptives. The two main preparations available today are depot medroxy progesterone acetate (DMPA) and norethisterone oenanthate (NET-OEN), but several other approaches are currently under clinical trial. Injectable contraceptives have some unique advantages which give them justifiably wide appeal amongst many groups of women. However, they do have a number of disadvantages including invariable menstrual disturbance and a delay in the return of fertility. One formulation of DMPA, Depo-Provera, is probably the most extensively investigated single hormonal contraceptive ever made. These studies indicate that it is remarkably safe and does not face any more unresolved issues than the combined pill, intrauterine device or tubal sterilization. However, for a number of disparate emotional and political reasons it has attracted the attention of several consumer and feminist groups, who have waged a prolonged and quite unjustified campaign against it. It is to be hoped that future debate will be conducted on a more informed, rational and less emotional basis. Injectable contraceptives should have an important place in the family planning armamentarium of all countries, and current developments should lead to a decrease in concerns about presently available agents. This should further increase the widespread acceptability of this approach to contraception.

  6. Clinical Trials

    Medline Plus

    Full Text Available ... part. Randomization Most clinical trials that have comparison groups use randomization. This involves assigning patients to different comparison groups by chance, rather than choice. This ...

  7. A multicenter, open-label trial to evaluate the quality of life in adults with ADHD treated with long-acting methylphenidate (OROS MPH): Concerta Quality of Life (CONQoL) study.

    Science.gov (United States)

    Mattos, Paulo; Louzã, Mário Rodrigues; Palmini, André Luís Fernandes; de Oliveira, Irismar Reis; Rocha, Fábio Lopes

    2013-07-01

    The available literature provides few studies on the effectiveness of methylphenidate in improving quality of life in individuals with ADHD. To assess the effectiveness of methylphenidate OROS formulation (OROS MPH) through QoL in adults with ADHD. A 12-week, multicenter, open-label trial involving 60 patients was used. The measures used were Adult Self-Rating Scale, Adult ADHD Quality of Life Scale (AAQoL), State and Trait Anxiety Inventory (STAI), Hamilton Depression Rating Scale (HAM-D), Clinical Global Impression (CGI), and safety measures. A significance statistic level of 5% was adopted. Analyses included 60 patients (66.7% male; M age = 31.1 years) for safety and 58 patients for effectiveness. All AAQoL subscales improved from baseline to Week 12 (p < .0001), as well as the Total AAQoL (p < .0001). A significant reduction on Clinical Global Impression-Improvement (CGI-I), HAM-D, STAI, and ASRS scores was observed (p < .0001). No serious adverse event was reported. Treatment of adult ADHD patients with OROS MPH improves QoL.

  8. Radioactive Substances Act 1960

    International Nuclear Information System (INIS)

    1960-01-01

    This Act regulates the keeping and use of radioactive material and makes provision for the disposal and storage of radioactive waste in the United Kingdom. It provides for a licensing system for such activities and for exemptions therefrom, in particular as concerns the United Kingdom Atomic Energy Authority. The Act repeals Section 4(5) of the Atomic Energy Authority Act, 1954 which made temporary provision for discharge of waste on or from premises occupied by the Authority. (NEA) [fr

  9. Learning dialog act processing

    OpenAIRE

    Wermter, Stefan; Löchel, Matthias

    1996-01-01

    In this paper we describe a new approach for learning dialog act processing. In this approach we integrate a symbolic semantic segmentation parser with a learning dialog act network. In order to support the unforeseeable errors and variations of spoken language we have concentrated on robust data-driven learning. This approach already compares favorably with the statistical average plausibility method, produces a segmentation and dialog act assignment for all utterances in a robust manner,...

  10. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Reform Could Impact People With CF The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements Advocacy News Briefings, Testimonies, and Regulatory ...

  11. Radiological Protection Act 1970

    International Nuclear Information System (INIS)

    1970-01-01

    This Act provides for the establishment of a Radiological Protection Board to undertake research and advise on protection from radiation hazards. Its functions include provision of advice to Government departments with responsibilities in relation to protection of sectors of the community or the community as a whole against the hazards of ionizing radiation. The Act, which lays down that the Board shall replace certain departments concerned with radiation protection, repeals several Sections of the Radioactive Substances Act 1948 and the Science and Technology Act 1965. (NEA) [fr

  12. The kinds of Ya in today Persian languag

    Directory of Open Access Journals (Sweden)

    S.Mohammadreza Ebnorrasool

    2014-12-01

    Full Text Available Abstract Diversity of suffix ‘-i’, called ‘ya’, in Persian language, which is of important consideration, for any reason, has not been able to attract scholars and grammarians in the field of Persian language. Here is an attempt to mention different kinds of ‘ya’ and to explain their applications, relying on grammar books, dictionaries, and today native application. The character generally has three types of applications in Persian language. It is firstly one of the Persian alphabet, so it primarily functions as a ‘phoneme’. It is applied in its second function when appears in the form of ’morpheme’, such as ‘-i’ in ‘mardi rad shod’ (a man passed with usage of indefinite article. The third function appears when it comes in the place of a word, because it is one of the six types of pronouns. So, ‘ya’ is applied in three forms: phoneme, morpheme and word. In continue, it is attempted to explain these kinds in more details. ‘ya’ as indefinite maker (Nakare: This kind of ‘ya’ is called the mark of indefinite by many of the Persian grammarians, including doctor Mohammad Moin. Dehkhoda says ‘ya’ is added to the end of the word to make it an indefinite one, such as the last word and it is a sign of indefinite types " of " is unknown, such as‘-i’ in ‘pesari ra didam’ (I saw a boy. ‘ya’ as numerical suffix means one (vahdat:  This kind is added to the last  of the word, and means "one". The difference between this one and the previous, ‘ya’ as indefinite maker, is just in their meanings. ‘ya’ as attributive suffix: This ‘ya’ is joined by various kinds of Persian words an attributes them to someone, some place or something, such as ‘Shirazi’(from shiraz, ‘farsi’(Persian, ‘Irani’(Iraian, Barmaki (Barmakian. This kind also sometimes has other meanings like emphasis, adverbial, degradation, similarity, vehicle, type, distance, and so on. ‘ya’ as addressing suffix (khetab

  13. 25 CFR 700.33 - Act (The Act).

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Act (The Act). 700.33 Section 700.33 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.33 Act (The Act). (a) The Act. The Act is Pub. L. 93-531, (88 Stat...

  14. Clinical Trials

    Medline Plus

    Full Text Available ... trial found that one of the combinations worked much better than the other for moderate persistent asthma. The results provided important treatment information for doctors and patients. The results from other clinical trials show what doesn't work or may cause harm. For example, the NHLBI ...

  15. Clinical Trials

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    Full Text Available ... the clinical trial you take part in, the information gathered can help others and add to scientific knowledge. People who take part in clinical trials are vital to the process of improving medical care. Many people volunteer because ...

  16. Clinical Trials

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    Full Text Available ... from other clinical trials show what doesn't work or may cause harm. For example, the NHLBI Women's Health Initiative ... safe a treatment is or how well it works. Children (aged 18 and younger) get ... legal consent for their child to take part in a clinical trial. When ...

  17. Clinical Trials

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    Full Text Available ... other expenses (for example, travel and child care)? Who will be in charge of my care? What will happen after the trial? Taking part in a clinical trial is your decision. Talk with your doctor about all of your treatment ...

  18. Clinical Trials

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    Full Text Available ... for trials with cutting-edge approaches, such as gene therapy or new biological treatments. Health insurance and health ... trials that involve high-risk procedures (such as gene therapy) or vulnerable patients (such as children). A DSMB's ...

  19. Clinical Trials

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    Full Text Available ... to Expect During a clinical trial, doctors, nurses, social workers, and other health care providers might be part of your treatment ... clinical trials are vital to the process of improving medical care. Many people ... participants, it may not work for you. A new treatment may have side ...

  20. Clinical Trials

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    Full Text Available ... Expect During a clinical trial, doctors, nurses, social workers, and other health care providers might be part of your treatment ... phase II clinical trials. The risk of side effects might be even greater for ... treatments. Health insurance and health care providers don't always ...

  1. Clinical Trials

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    Full Text Available ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, talk with your doctor. He or she may know about studies going on in your area. You can visit the following website to learn more about ...

  2. Clinical Trials

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    Full Text Available ... benefits of lowering high blood pressure in the elderly outweighed the risks. Other examples of clinical trials ... child to enroll. Also, children aged 7 and older often must agree (assent) to ... as clinical trials for adults. For more information, go to "How Do Clinical ...

  3. Clinical Trials

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    Full Text Available ... products, such as medicines, and how well they work. The U.S. Food and Drug Administration (FDA) oversees these clinical trials. ... cancer also increased. As a result, the U.S. Food and Drug Administration now recommends never using HT ... Clinical Trials Work If you take ...

  4. “Mind the Gap”—The Impact of Variations in the Duration of the Treatment Gap and Overall Treatment Time in the First UK Anal Cancer Trial (ACT I)

    International Nuclear Information System (INIS)

    Glynne-Jones, Rob; Sebag-Montefiore, David; Adams, Richard; McDonald, Alec; Gollins, Simon; James, Roger; Northover, John M.A.; Meadows, Helen M.; Jitlal, Mark

    2011-01-01

    Purpose: The United Kingdom Coordinating Committee on Cancer Research anal cancer trial demonstrated the benefit of combined modality treatment (CMT) using radiotherapy (RT), infusional 5-fluorouracil, and mitomycin C over RT alone. The present study retrospectively examines the impact of the recommended 6-week treatment gap and local RT boost on long-term outcome. Methods and Materials: A total of 577 patients were randomly assigned RT alone or CMT. After a 6-week gap responders received a boost using either additional external beam radiotherapy (EBRT) (15 Gy) or iridium-192 implant (25 Gy). The effect of boost, the gap between initial treatment (RT alone or CMT) and boost (Tgap), and overall treatment time (OTT) were examined for their impact on outcome. Results: Among the 490 good responders, 436 (89%) patients received a boost after initial treatment. For boosted patients, the risk of anal cancer death decreased by 38% (hazard ratio [HR]: 0.62, 99% CI 0.35–1.12; p = 0.04), but there was no evidence this was mediated via a reduction in locoregional failure (LRF) (HR: 0.90, 99% CI 0.48–1.68; p = 0.66). The difference in Tgap was only 1.4 days longer for EBRT boost, compared with implant (p = 0.51). OTT was longer by 6.1 days for EBRT (p = 0.006). Tgap and OTT were not associated with LRF. Radionecrosis was reported in 8% of boosted, compared with 0% in unboosted patients (p = 0.03). Conclusions: These results question the benefit of a radiotherapy boost after a 6-week gap. The higher doses of a boost may contribute more to an increased risk of late morbidity, rather than local control.

  5. Aggregating todays data for tomorrows science: a geological use case

    Science.gov (United States)

    Glaves, H.; Kingdon, A.; Nayembil, M.; Baker, G.

    2016-12-01

    Geoscience data is made up of diverse and complex smaller datasets that, when aggregated together, build towards what is recognised as `big data'. The British Geological Survey (BGS), which acts as a repository for all subsurface data from the United Kingdom, has been collating these disparate small datasets that have been accumulated from the activities of a large number of geoscientists over many years. Recently this picture has been further complicated by the addition of new data sources such as near real-time sensor data, and industry or community data that is increasingly delivered via automatic donations. Many of these datasets have been aggregated in relational databases to form larger ones that are used to address a variety of issues ranging from development of national infrastructure to disaster response. These complex domain-specific SQL databases deliver effective data management using normalised subject-based database designs in a secure environment. However, the isolated subject-oriented design of these systems inhibits efficient cross-domain querying of the datasets. Additionally, the tools provided often do not enable effective data discovery as they have problems resolving the complex underlying normalised structures. Recent requirements to understand sub-surface geology in three dimensions have led BGS to develop new data systems. One such solution is PropBase which delivers a generic denormalised data structure within an RDBMS to store geological property data. Propbase facilitates rapid and standardised data discovery and access, incorporating 2D and 3D physical and chemical property data, including associated metadata. It also provides a dedicated web interface to deliver complex multiple data sets from a single database in standardised common output formats (e.g. CSV, GIS shape files) without the need for complex data conditioning. PropBase facilitates new scientific research, previously considered impractical, by enabling property data

  6. An additional bolus of rapid-acting insulin to normalise postprandial cardiovascular risk factors following a high-carbohydrate high-fat meal in patients with type 1 diabetes: A randomised controlled trial.

    Science.gov (United States)

    Campbell, Matthew D; Walker, Mark; Ajjan, Ramzi A; Birch, Karen M; Gonzalez, Javier T; West, Daniel J

    2017-07-01

    To evaluate an additional rapid-acting insulin bolus on postprandial lipaemia, inflammation and pro-coagulation following high-carbohydrate high-fat feeding in people with type 1 diabetes. A total of 10 males with type 1 diabetes [HbA 1c 52.5 ± 5.9 mmol/mol (7.0% ± 0.5%)] underwent three conditions: (1) a low-fat (LF) meal with normal bolus insulin, (2), a high-fat (HF) meal with normal bolus insulin and (3) a high-fat meal with normal bolus insulin with an additional 30% insulin bolus administered 3-h post-meal (HFA). Meals had identical carbohydrate and protein content and bolus insulin dose determined by carbohydrate-counting. Blood was sampled periodically for 6-h post-meal and analysed for triglyceride, non-esterified-fatty acids, apolipoprotein B48, glucagon, tumour necrosis factor alpha, fibrinogen, human tissue factor activity and plasminogen activator inhibitor-1. Continuous glucose monitoring captured interstitial glucose responses. Triglyceride concentrations following LF remained similar to baseline, whereas triglyceride levels following HF were significantly greater throughout the 6-h observation period. The additional insulin bolus (HFA) normalised triglyceride similarly to low fat 3-6 h following the meal. HF was associated with late postprandial elevations in tumour necrosis factor alpha, whereas LF and HFA was not. Fibrinogen, plasminogen activator inhibitor-1 and tissue factor pathway levels were similar between conditions. Additional bolus insulin 3 h following a high-carbohydrate high-fat meal prevents late rises in postprandial triglycerides and tumour necrosis factor alpha, thus improving cardiovascular risk profile.

  7. "USA Today": Comparative Analysis with Two National and Two Los Angeles Daily Newspapers. Research Bulletin.

    Science.gov (United States)

    Ames, Steve; And Others

    Sections of the newspaper "USA Today" were compared with corresponding sections of four major newspapers--the "New York Times," the "Wall Street Journal," the "Los Angeles Herald Examiner," and the "Los Angeles Times"--to determine what editorial components made "USA Today" different and…

  8. Immigrants as Refugees of the Global Economy: Learning to Teach (about) Today's Migrants

    Science.gov (United States)

    Reed, Judith

    2015-01-01

    The phenomenon of migration as it is known today must be understood in the larger context of the globalized economy and the "race to the bottom" that characterizes the multinational corporate relationship with the global South. A deeper understanding of the ways in which migration today is rooted in the machinations of the globalized…

  9. Computer Literacy for Life Sciences: Helping the Digital-Era Biology Undergraduates Face Today's Research

    Science.gov (United States)

    Smolinski, Tomasz G.

    2010-01-01

    Computer literacy plays a critical role in today's life sciences research. Without the ability to use computers to efficiently manipulate and analyze large amounts of data resulting from biological experiments and simulations, many of the pressing questions in the life sciences could not be answered. Today's undergraduates, despite the ubiquity of…

  10. Leadership and the Millennials: Transforming Today's Technological Teens into Tomorrow's Leaders

    Science.gov (United States)

    Wisniewski, Mary Ann

    2010-01-01

    Although older and younger generations unfailingly tend to disagree on values and are inclined to perceive one another with a degree of skepticism and disapproval, it is an unmistakable reality that because of technology today's youth are approaching life differently than previous generations. It is also clear that today's Millennials are…

  11. The Employment Equation: Why Our Young People Need More Maths for Today's Jobs

    Science.gov (United States)

    Hodgen, Jeremy; Marks, Rachel

    2013-01-01

    This report reviews over 50 research studies to consider the level and type of mathematical skills needed by employers in today's economy. It considers five key questions: (1) What mathematics (level and content) is required in the workplace today?; (2) How and why have the mathematical needs of the workplace changed over time?; (3) In what ways…

  12. Towards understanding international migration determinants today: Theoretical perspective

    Directory of Open Access Journals (Sweden)

    Predojević-Despić Jelena

    2010-01-01

    significantly different from those which lead to their stabilization in time and space. Although differences in the income height, risks, employment possibilities, market expansion can all influence the continuation of spatial movement of population, new conditions which arise during migration begin to act as independent factors: development of migratory networks, institutionalized support to the development of trans-national activities, as well as changing the social context of work in countries of destination. Therefore, in the analysis of contemporary international migrations the necessity arises for a systematic approach, namely dynamic perspective of research - from recognition to a detailed insight in changeable trends and forms of contemporary migratory movements in the world. In addition, at the same time with the development of new markets, regional economies and technology centers, there has been a 'trans-national turnabout' in the last fifteen years or so in researching migrations, namely a significant development in the approach which stresses the relations which migrants maintain with their families, communities and cultures which are out of the country in which they migrated in. The final part of the paper calls for the requirement of the following: coordination of theoretical concepts with new social conditions, post-industrial world and global processes of transformations in which migrations have an important role; overcoming inadequate coordination and isolation in studying migrations within special scientific disciplines, as well as poor connections of certain aspects of migration study; research of the causes and consequences of migrations as an inseparable part of the general process of social development. .

  13. Marine Mammal Protection Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Mammal Protection Act (MMPA or Act) prohibits, with certain exceptions, the "take" of marine mammals in U.S. waters and by U.S. citizens on the high seas,...

  14. Collective speech acts

    NARCIS (Netherlands)

    Meijers, A.W.M.; Tsohatzidis, S.L.

    2007-01-01

    From its early development in the 1960s, speech act theory always had an individualistic orientation. It focused exclusively on speech acts performed by individual agents. Paradigmatic examples are ‘I promise that p’, ‘I order that p’, and ‘I declare that p’. There is a single speaker and a single

  15. Americans with Disabilities Act.

    Science.gov (United States)

    Kaesberg, Mary Ann; Murray, Kenneth T.

    1994-01-01

    Presents a 35-item checklist of practical activities for school district compliance with the Americans with Disabilities Act (ADA). The checklist is based on ADA statutes, other civil rights legislation and litigation, as well as pertinent regulations and the legislative history of the act contained in the Congressional Record. (MLF)

  16. Radiation emitting devices act

    International Nuclear Information System (INIS)

    1970-01-01

    This Act, entitled the Radiation Emitting Devices Act, is concerned with the sale and importation of radiation emitting devices. Laws relating to the sale, lease or import, labelling, advertising, packaging, safety standards and inspection of these devices are listed as well as penalties for any person who is convicted of breaking these laws

  17. Nuclear Installations Act 1969

    International Nuclear Information System (INIS)

    1969-01-01

    The purpose of this Act is to amend the Nuclear Installations Act 1965 to bring it into full compliance with the international conventions on nuclear third party liability to which the United Kingdom is a Signatory, namely, the Paris Convention, the Brussels Supplementary Convention and the Vienna Convention. (NEA) [fr

  18. Patient centric approach for clinical trials: Current trend and new opportunities.

    Science.gov (United States)

    Sharma, Neha Shankar

    2015-01-01

    The clinical research industry today is undergoing a major facelift. Companies are continuously looking to adopt and implement effective and innovative ways to accelerate drug launches in the market. Companies today are more open and do not view patients as mere "subjects" who generate data, - but as informed collaborators whose participation is "core" to the overall success of trials leading to the emergence of the concept of "patient-centric trials." This paper is intended to highlight the current trends and new opportunities that can be seen in industry -indicative of crucial role patients today play in their own health care using technology, social media and self education.

  19. Patient centric approach for clinical trials: Current trend and new opportunities

    Directory of Open Access Journals (Sweden)

    Neha Shankar Sharma

    2015-01-01

    Full Text Available The clinical research industry today is undergoing a major facelift. Companies are continuously looking to adopt and implement effective and innovative ways to accelerate drug launches in the market. Companies today are more open and do not view patients as mere "subjects" who generate data, - but as informed collaborators whose participation is "core" to the overall success of trials leading to the emergence of the concept of "patient-centric trials." This paper is intended to highlight the current trends and new opportunities that can be seen in industry -indicative of crucial role patients today play in their own health care using technology, social media and self education.

  20. The Radiation Protection Act

    International Nuclear Information System (INIS)

    Persson, L.

    1989-01-01

    The new Radiation Protection Act (1988:220) entered into force in Sweden on July 1st, 1988. This book presents the Act as well as certain regulations connected to it. As previously, the main responsibility for public radiation protection will rest with one central radiation protection authority. According to the 1988 Act, the general obligations with regard to radiation protection will place a greater responsibility than in the past on persons carrying out activities involving radiation. Under the act, it is possible to adjust the licensing and supervisory procedures to the level of danger of the radiation source and the need for adequate competence, etc. The Act recognises standardised approval procedures combined with technical regulations for areas where the risks are well known. The Act contains several rules providing for more effective supervision. The supervising authority may in particular decide on the necessary regulations and prohibitions for each individual case. The possibilities of using penal provisions have been extended and a rule on the mandatory execution of orders has been introduced. The Ordinance on Radiation Protection (1988:293) designates the National Institute of Radiation Protection (SSI) as the central authority referred to in the Radiation Protection Act. The book also gives a historic review of radiation protection laws in Sweden, lists regulations issued by SSI and presents explanations of radiation effects and international norms in the area. (author)

  1. Canada's Clean Air Act

    International Nuclear Information System (INIS)

    2006-01-01

    This paper provided an outline of Canada's Clean Air Act and examined some of the regulatory changes that will occur as a result of its implementation. The Act is being introduced to strengthen the legislative basis for taking action on reducing air pollution and GHGs, and will allow the government to regulate both indoor and outdoor air pollutants and GHGs. The Act will require the Ministers of the Environment and Health to establish national air quality objectives, as well as to monitor and report on their attainment. The Canadian Environmental Protection Act will be amended to enable the government to regulate the blending of fuels and their components. The Motor Vehicle Fuel Consumption Standards Act will also be amended to enhance the government's authority to regulate vehicle fuel efficiency. The Energy Efficiency Act will also be expanded to allow the government to set energy efficiency standards and labelling requirements for a wider range of consumer and commercial products. The Act will commit to short, medium and long-term industrial air pollution targets. Regulations will be proposed for emissions from industry; on-road and off-road vehicles and engines; and consumer and commercial products. It was concluded that the Government of Canada will continue to consult with provinces, territories, industries and Canadians to set and reach targets for the reduction of both indoor and outdoor air pollutants and GHG emissions. 6 figs

  2. Clinical Trials

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    Full Text Available ... include factors such as a patient's age and gender, the type and stage of disease, and whether ... How long will the trial last? Who will pay for the tests and treatments I receive? Will ...

  3. Clinical Trials

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    Full Text Available ... medicines, and how well they work. The U.S. Food and Drug Administration (FDA) oversees these ... trials are a key research tool for advancing medical knowledge and patient care. ...

  4. Clinical Trials

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    Full Text Available ... strict scientific standards. These standards protect patients and help produce reliable study results. Clinical trials are one ... are important because they advance medical knowledge and help improve patient care. Sponsorship and Funding The National ...

  5. Clinical Trials

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    Full Text Available ... patients to find out whether a new approach causes any harm. In later phases of clinical trials, ... device improves patient outcomes; offers no benefit; or causes unexpected harm All of these results are important ...

  6. Clinical Trials

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    Full Text Available ... and compare new treatments with other available treatments. Steps To Avoid Bias The researchers doing clinical trials take steps to avoid bias. "Bias" means that human choices ...

  7. Clinical Trials

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    Full Text Available ... gathered can help others and add to scientific knowledge. People who take part in clinical trials are vital to the process of improving medical care. Many people volunteer because they want to help others. ...

  8. Clinical Trials

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    Full Text Available ... materials, and offer advice on research-related issues. Data Safety Monitoring Board Every National Institutes of Health ( ... III clinical trial is required to have a Data and Safety Monitoring Board (DSMB). This board consists ...

  9. Clinical Trials

    Science.gov (United States)

    ... of Personal Stories Peers Celebrating Art Peers Celebrating Music Be Vocal Support Locator DBSA In-Person Support ... by participating in a clinical trial is to science first and to the patient second. More About ...

  10. Clinical Trials

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    Full Text Available ... to Expect During a clinical trial, doctors, nurses, social workers, and other health care providers might be ... the new approach. You also will have the support of a team of health care providers, who ...

  11. Clinical Trials

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    Full Text Available ... final stages of a long and careful research process. The process often begins in a laboratory (lab), where scientists ... part in clinical trials are vital to the process of improving medical care. Many people volunteer because ...

  12. Clinical Trials

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    Full Text Available ... as gene therapy) or vulnerable patients (such as children). A DSMB's role is to review data from a clinical trial for safety problems or differences in results among different groups. The DSMB also reviews research results ...

  13. Clinical Trials

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    Full Text Available ... medical centers and doctors' offices around the country. Benefits and Risks Possible Benefits Taking part in a clinical trial can have many benefits. For example, you may gain access to new ...

  14. Clinical Trials

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    Full Text Available ... or treatment is having harmful effects. Food and Drug Administration In the United States, the Food and Drug Administration (FDA) provides oversight for clinical trials that ...

  15. Clinical Trials

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    Full Text Available ... Usually, a computer program makes the group assignments. Masking The term "masking" refers to not telling the clinical trial participants which treatment they're getting. Masking, or "blinding," helps avoid bias. For this reason, ...

  16. Clinical Trials

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    Full Text Available ... you to explore NIH Clinical Center for patient recruitment and clinical trial information. For more information, please email the NIH Clinical Center Office of Patient Recruitment at cc-prpl@cc.nih.gov or call ...

  17. Clinical Trials

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    Full Text Available ... organizations also sponsor clinical trials. Examples include Government Agencies, such as the U.S. Departments of Defense and ... how you feel. Some people will need to travel or stay in hospitals to take part in ...

  18. Clinical Trials

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    Full Text Available ... clinical trials are required to have an IRB. Office for Human Research Protections The U.S. Department of Health and Human Services’ (HHS’) Office for Human Research Protections (OHRP) oversees all research ...

  19. Clinical Trials

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    Full Text Available ... clinical trial. IRB members are doctors, statisticians, and community members. The IRB's purpose is to ensure that ... lung, and blood disorders. By engaging the research community and a broad group of stakeholders and advisory ...

  20. Clinical Trials

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    Full Text Available ... successfully developed and evaluated to fill an important gap in information and education for parents, clinicians, researchers, ... gathered can help others and add to scientific knowledge. People who take part in clinical trials are ...

  1. Clinical Trials

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    Full Text Available ... Masking, or "blinding," helps avoid bias. For this reason, researchers also may not be told which treatments ... from a study at any time, for any reason. Also, during the trial, you have the right ...

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    Full Text Available Skip to main content U.S. Department of Health & Human Services Health Topics Health Topics A-Z Clinical Trials Publications and Resources Health Education and Awareness The Science Science Home Blood Disorders and ...

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    Full Text Available ... get special protection as research subjects. Almost always, parents must give legal consent for their child to ... trial's potential risks are greater than minimal, both parents must give permission for their child to enroll. ...

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    Full Text Available ... risk of heart disease in the first few years, and HT also increased the risk of stroke ... a safety measure. They ensure a trial excludes any people for whom the protocol has known risks ...

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    Full Text Available ... Initiative tested whether hormone therapy (HT) reduced the risk of heart disease in postmenopausal women. (When the trial began, HT was already in common use for the treatment of menopausal symptoms. It also ...

  6. Clinical Trials

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    Full Text Available ... results. Clinical trials are one of the final stages of a long and careful research process. The ... a patient's age and gender, the type and stage of disease, and whether the patient has had ...

  7. Clinical Trials

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    Full Text Available ... risk of heart disease in the first few years, and HT also increased the risk of stroke ... master plan called a protocol (PRO-to-kol). This plan explains how the trial will work. The ...

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    Full Text Available ... Clinical Trials Publications and Resources Health Education and Awareness The Science Science Home Blood Disorders and Blood ... of estrogen and progestin, the risk of breast cancer also increased. As a result, the U.S. Food ...

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    Full Text Available ... issues arise. Participation and Eligibility Each clinical trial defines who is eligible to take part in the ... the strategy or treatment is having harmful effects. Food and Drug Administration In the United States, the ...

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    Full Text Available Skip to main content U.S. Department of Health & Human Services Health Topics Health Topics A-Z Clinical Trials Publications and Resources Health Education and Awareness The Science Science Home Blood Disorders ...

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    Full Text Available ... treatment is having harmful effects. Food and Drug Administration In the United States, the Food and Drug ... life? Will I have to be in the hospital? How long will the trial last? Who will ...

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    Full Text Available ... the same scientific safeguards as clinical trials for adults. For more information, go to "How Do Clinical ... based on what is known to work in adults. To improve clinical care of children, more studies ...

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    Full Text Available ... A-Z Clinical Trials Publications and Resources Health Education and Awareness The Science Science Home Blood Disorders ... to fill an important gap in information and education for parents, clinicians, researchers, children, and the general ...

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    Full Text Available ... clinical care of children, more studies are needed focusing on children's health with the goal to develop ... study? How might this trial affect my daily life? Will I have to be in the hospital? ...

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    Full Text Available ... procedures painful? What are the possible risks, side effects, and benefits of taking part in the study? How might this trial affect my daily life? Will I have to be in the hospital? ...

  16. Clinical Trials

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    Full Text Available ... work best for certain illnesses or groups of people. Clinical trials produce the best data available for ... or animals doesn't always work well in people. Thus, research in humans is needed. For safety ...

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    Full Text Available ... sponsor clinical trials. Examples include Government Agencies, such as the U.S. Departments of Defense and Veterans Affairs; ... age and frequency for doing screening tests, such as mammography; and compare two or more screening tests ...

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    Full Text Available ... harm. In later phases of clinical trials, researchers learn more about the new approach's risks and benefits. ... explore whether surgery or other medical treatments produce better results for certain illnesses or groups of people; ...

  19. Clinical Trials

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    Full Text Available ... offer a variety of funding mechanisms tailored to planning and conducting clinical trials at all phases, including ... Center for Health Information Email Alerts Jobs and Careers Site Index About NHLBI National Institute of Health ...

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    Full Text Available ... Blood Safety Sleep Science and Sleep Disorders Lung Diseases Heart and Vascular Diseases Precision Medicine Activities Obesity, Nutrition, ... whether hormone therapy (HT) reduced the risk of heart disease in postmenopausal women. (When the trial began, HT ...

  1. Clinical Trials

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    Full Text Available ... patients. Usually, a computer program makes the group assignments. Masking The term "masking" refers to not telling ... questions to ask your doctor and the research staff, go to "How Do Clinical Trials Protect Participants?" ...

  2. Clinical Trials

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    Full Text Available ... study explored whether the benefits of lowering high blood pressure in the elderly outweighed the risks. Other examples of clinical trials that test principles or strategies include studies that explore whether ...

  3. Clinical Trials

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    Full Text Available ... are ethical and that the participants' rights are protected. The IRB reviews the trial's protocol before the ... may know about studies going on in your area. You can visit the following website to learn ...

  4. Clinical Trials

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    Full Text Available ... treatment is having harmful effects. Food and Drug Administration In the United States, the Food and Drug Administration (FDA) provides oversight for clinical trials that are ...

  5. Clinical Trials

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    Full Text Available ... a laboratory (lab), where scientists first develop and test new ideas. If an approach seems promising, the ... Centers (including the NHLBI) usually sponsor trials that test principles or strategies. For example, one NHLBI study ...

  6. Clinical Trials

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    Full Text Available ... Children and Clinical Studies Program has been successfully developed and evaluated to fill an important gap in ... Possible Benefits Taking part in a clinical trial can have many benefits. For example, you may gain ...

  7. Clinical Trials

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    Full Text Available ... questions to ask your doctor and the research staff, go to "How Do Clinical Trials Protect Participants?" ... in Bethesda, Maryland. The physicians, nurses, scientists and staff of the NHLBI encourage you to explore NIH ...

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    Full Text Available ... Science Science Home Blood Disorders and Blood Safety Sleep Science and Sleep Disorders Lung Diseases Heart and Vascular Diseases Precision ... women and that are ethnically diverse. Children also need clinical trials that focus on them, as medical ...

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    Full Text Available ... and evaluated to fill an important gap in information and education for parents, clinicians, researchers, children, and the general public. What to Expect During a clinical trial, ...

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    Full Text Available ... small groups of people for safety and side effects. Phase II clinical trials look at how well ... confirm how well treatments work, further examine side effects, and compare new treatments with other available treatments. ...

  11. Clinical Trials

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    Full Text Available ... whether hormone therapy (HT) reduced the risk of heart disease in postmenopausal women. (When the trial began, HT ... also was increasingly being used for prevention of heart disease.) The study found that HT increased the risk ...

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    Full Text Available ... trials optimization . Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Get ... and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Connect ...

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    Full Text Available ... Events About NHLBI About NHLBI Home Mission and Strategic Vision Leadership Scientific Divisions Operations and Administration Advisory ... offer a variety of funding mechanisms tailored to planning and conducting clinical trials at all phases, including ...

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    Full Text Available ... NHLBI About NHLBI Home Mission and Strategic Vision Leadership Scientific Divisions Operations and Administration Advisory Committees Budget ... always, parents must give legal consent for their child to take part in a clinical trial. When ...

  15. Clinical Trials

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    Full Text Available ... and organizations also sponsor clinical trials. Examples include Government Agencies, such as the U.S. Departments of Defense and Veterans Affairs; private companies; universities; and nonprofit organizations. NIH Institutes and ...

  16. Clinical Trials

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    Full Text Available ... records can quickly show this information if safety issues arise. Participation and Eligibility Each clinical trial defines ... and materials, and offer advice on research-related issues. Data Safety Monitoring Board Every National Institutes of ...

  17. Clinical Trials

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    Full Text Available ... that the participants' rights are protected. The IRB reviews the trial's protocol before the study begins. An IRB will only approve research that deals with medically important questions ...

  18. Clinical Trials

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    Full Text Available ... women and that are ethnically diverse. Children also need clinical trials that focus on them, as medical ... often differ for children. For example, children may need lower doses of certain medicines or smaller medical ...

  19. Clinical Trials

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    Full Text Available ... you may get tests or treatments in a hospital, clinic, or doctor's office. In some ways, taking ... people will need to travel or stay in hospitals to take part in clinical trials. For example, ...

  20. Clinical Trials

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    Full Text Available ... care providers might be part of your treatment team. They will monitor your health closely. You may ... taking part in a clinical trial. Your treatment team also may ask you to do other tasks. ...