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Sample records for tim pelaksana fakultas

  1. PERBEDAAN WAKTU REAKSI PADA BERBAGAI DURASI LATIHAN DAN INDEKS MASSA TUBUH PADA TIM FUTSAL FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA TAHUN 2014

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    I Putu Gede Windhu Saputra

    2015-06-01

    Full Text Available Futsal merupakan salah satu olahraga permainan bola yang kini makin digemari oleh banyak orang. Permainan futsal membutuhkan kondisi jasmani, kemampuan menggiring bola, mencetak gol, dan menghadang lawan yang baik. Berbagai kemampuan tersebut membutuhkan latihan rutin, indeks massa tubuh (IMT, serta waktu reaksi yang optimal agar dapat bermain dengan baik. Penelitian ini ingin melihat bagaimana perbedaan waktu reaksi pada berbagai durasi latihan dan IMT pada pemain tim futsal FK UNUD. Penelitian ini dilakukan dengan metode analisis potong lintang dengan melihat perbedaan waktu reaksi berdasarkan durasi latihan dan IMT. Dari hasil uji T menunjukkan tidak didapatkan perbedaan bermakna dari rata-rata waktu reaksi (p>0,05 antara pemain yang berlatih kurang dari 5 jam per minggu (266,67 milidetik ± 22,223 dibandingkan dengan pemain yang berlatih lebih dari 5 jam per minggu (305,67 milidetik ± 45,247. Tidak didapatkan pula perbedaan signifikan (p>0,05 antara pemain yang memiliki indeks massa tubuh dibawah 25 kg/m2 (283,80 milidetik ± 37,067 dan yang memiliki indeks massa tubuh lebih dari sama dengan 25 kg/m2 (302,40 milidetik ± 51,897. Kesimpulan dari penelitian ini tidak didapatkan perbedaan waktu reaksi yang signifikan antara kelompok pemain yang berlatih kurang dari 5 jam per minggu dibandingkan dengan kelompok pemain yang berlatih lebih dari sama dengan 5 jam per minggu. Tidak didapatkan perbedaan waktu reaksi yang signifikan pada kelompok pemain dengan IMT kurang dari 25 kg/m2 dibandingkan dengan kelompok pemain dengan IMT lebih dari sama dengan 25 kg/m2.    

  2. KEBUTUHAN PELATIHAN PENYULUH PERTANIAN BERBASIS KOMPETENSI PADA BADAN PELAKSANA PENYULUHAN KABUPATEN SAROLANGUN PROVINSI JAMBI

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    Dessy Liani

    2014-09-01

    Full Text Available ABSTRACTThis study aimed to 1 identify the perceptions of agricultural extension of training management at “Badan Pelaksana Penyuluhan Kabupaten Sarolangun”; 2 identify the perceptions of agricultural instructor on performance; 3 analyzing the agricultural training needs to be held, and the type of training needs to be done based on the analysis of the work load and competency. The data were processed using a range of criteria techniques, Tools Training Need Assessment (TNA-T and T-Test. The results showed the whole perception of agricultural extension at all functional level positions are quite satisfied with the training organized by “Badan Pelaksana Penyuluhan Kabupaten Sarolangun”. Perception on the performance of young agricultural instructor, expert agricultural instructor and agricultural instructor supervisor is high. Meanwhile the performance of advanced agricultural instructor and skilled-implementer agricultural instructor is high enough. Performance levels across functional departments of agricultural instructor at Badan Pelaksana Penyuluhan Kabupaten Sarolangun is high enough although not all of them achieve the desired result by the organization due to the lack of infrastructure and extension facilities. Therefore more trainings to enhance their knowledge and skills could be done to obtain high performing agricultural instructor.Keywords: agricultural extension, performance, competency-based training, range criteria techniques, training need assessment toolsABSTRAKPenelitian ini bertujuan 1 mengidentifikasi persepsi penyuluh pertanian terhadap pelatihan yang pernah diikuti  yang dilihat dari manajemen pelatihan yang terdapat pada Badan Pelaksana Penyuluhan Kabupaten Sarolangun; 2 mengidentifikasi persepsi penyuluh pertanian tentang  kinerja; 3 menganalisis tingkat kebutuhan pelatihan penyuluh pertanian yang akan diadakan dan jenis pelatihan yang perlu dilakukan berdasarkan analisis kemampuan kerja jabatan dan kemampuan

  3. HUBUNGAN PENGETAHUAN DENGAN PERILAKU ASERTIF PUSTAKAWAN DALAM MEMBINA HUBUNGAN INTERPERSONAL DI PERPUSTAKAAN FAKULTAS GEOGRAFI UGM

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    Budhi Santoso

    2016-10-01

    Full Text Available Abstrak Kualitas layanan perpustakaan sangat dipengaruhi oleh kualitas pustakawan sebagai pelaksana. Kualitas pustakawan ditentukan oleh latar belakang pendidikan (keahlian, kepribadian dan kemampuan berkomunikasi. Selain berkomunikasi interpersonal, pengetahuan berperilaku arsertif juga merupakan keterampilan yang harus dikuasi oleh pustakawan dalam membina hubungan baik dengan pemustaka dalam upaya memenuhi kepuasan pemustaka terhadap layanan yang kita berikan. Dari uraian diatas pengetahuan tentang keterampilan asertif dan keterampilan komunikasi interpersonal sangat di butuhkan pustakawan dalam memberikan pelayanan prima kepada pemustaka dalam pemenuhan kebutuhan akan informasi dan membina hubungan yang baik dengan pemustaka kita. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan dengan perilaku asertif Pustakawan dalam membina hubungan interpersonal. Peneliti mengunakan teknik sampel jenuh yaitu meneliti keseluruhan populasi pustakawan Fakultas Geografi UGM yang berjumlah 5 pustakawan. Metode pengumpulan data yang digunakan dalam penelitian ini adalah dalam bentuk angket yaitu berupa kuisioner. Hasil penelitian ini adalah sebanyak 1 orang (20% belum pernah mengikuti seminar yang membahas masalah komunikasi. Mayoritas pengetahuan pustakawan tentang perilaku asertif adalah dalam katagori baik yaitu sebanyak 4 (80%, dan 1 pustakawan dalam kategori kurang (n=1 20%. Mayoritas perilaku asertif pustakawan dalam membina hubungan interpersonal (n = 4; 80 % adalah dalam katagori sedang,  dan 1 pustakawan dalam kategori baik (n=1 20%. Hasil uji korelasi melalui analisa Pearson didapat hasil bahwa tidak ada hubungan yang signifikan antara pengetahuan dengan perilaku asertif pustakawan dalam membina hubungan interpersonal di Fakultas Geografi UGM. (p value = 0,442.   Kata kunci :     Asertivitas, Perilaku asertif pustakawan, Hubungan                 interpersonal. AbstractThe paper presents a relationship between

  4. Profil Soft skills Mahasiswa Pendidikan Teknik Boga (PTB Fakultas Teknik Universitas Negeri Yogyakarta

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    Siti Hamidah

    2013-01-01

    Full Text Available Abstrak: Profil Soft skills Mahasiswa Pendidikan Teknik Boga (PTB Fakultas Teknik Universitas Negeri Yogyakarta. Penelitian ini bertujuan untuk memperoleh gambaran kekuatan dan kelemahan 9 soft skills mahasiswa PTB. Penelitian  diskriptif ini dilaksanakan di Program Studi PTB dengan menggunakan kuesioner respon. Sampel penelitian adalah semua mahasiswa semester 6. Data dianalisis secara diskriptif kuantitatif. Hasil Penelitian menunjukkan bahwa kekuatan soft skills mahasiswa PTB secara berturut adalah:  kemampuan untuk selalu belajar (72,89%, tanggung jawab (70,77%,  kerja sama dalam tim (68,61%, komitmen (67,96%, kreativitas (67,25%, disiplin (64,79%, usaha keras mencapai sukses (62,68%, pemecahan masalah (55,87%, komunikasi (49,90%. Keadaan kelemahan soft skills secara berturut: komunikasi (50,10%, pemecahan masalah (44, 13%,  usaha keras mencapai sukses (37,32%,  disiplin (35,21%, kreativitas (32,75%, komitmen (32,04%, kerjasama dalam tim (31,39%, tanggung jawab (29,23%, kemampuan untuk selalu belajar (27,11%. Dapat dinyatakan bahwa keadaan profil soft skills tersebut merupakan  hasil pengasuhan soft skills melalui pola pembelajaran model terpisah, terintegarsi dan   komplementatif. Kata kunci: profil, soft skills, mahasiswa

  5. MODEL TANAMAN HORTIKULTURA ORGANIK PADA UNIT PELAKSANA TEKNIS PERTANIAN TERPADU UNIVERSITAS LANCANG KUNING

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    Latifa Siswati

    2016-03-01

    Full Text Available ABSTRAKPenelitian ini mengetahui model pertanian tanaman hortikultura organic  .Pertanian organik merupakan suatu usahatani untuk melakukan pemberian pupuk berasal dari urin sapi dan tidak mengandung zat kimia . ini berarti limbah yang dihasilkan akan dimanfaatkan kembali menjadi sumberdaya yang dapat menghasilkan.  Pada penelitian ini tujuan yang ingin dicapai adalah menemukan tanaman hortikultura organik. Mengetahui pendapatan jenis hortikultura.menerapkan pengembangan agribisnis tanaman unggulan dengan   pupuk urin sapi di lahan  dengan pertanian terpadu memiliki manfaat ekonomis dan ekologis.Metode penelitian adalah ekperimen , dilakukan penanaman tanaman hortikultura kangkung,timun, pare, gambas Unit Pelaksana Teknis Univ.Lancang Kuning kota Pekanbaru. Penelitian ini  dapat memberikan model tanaman hortikultura organic serta  mengurangi biaya pupuk tanaman.Hasil penelitian Model tanaman kacang panjang diberikan pupuk urin sapi  yang terbaik. penaman sayur di Unit Pelaksana Teknis  Pertanian terpadu diperoleh hasil tanaman dengan pemakaian pupuk urin cair terjadi peningkatan berat tanaman .Pendapatan pertanian terpadu Rp 514.000- per periode.Key word: pupuk cair, hortikultura,pendapatan 

  6. Aktor Pelaksana Pengelolaan Transportasi Publik Perkotaan (Studi Kasus Bus Trans Metro Di Kota Pekanbaru

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    Raden Imam Al Hafis

    2014-04-01

    Full Text Available Modernisasi dalam bidang transportasi merupakan suatu terobosan bagi pemerintah untuk memperbaiki sistem pelayanan dalam bidang angkutan umum. Pertumbuhan ekonomi suatu negara atau bangsa tergantung tersedianya pengangkutan dalam negara atau bangsa yang bersangkutan. Agar hal tersebut bisa terwujud, maka dalam pengelolaannya diperlukan aktor lain diluar pemerintah agar pelaksanaan kebijakan dapat disinergikan sehingga dapat memperoleh hasil yang maksimal dalam pencapaian tujuan dari kebijakan. Penelitian yang digunakan adalah penelitian deskriptif kualitatif, yakni jenis penelitian yang menggambarkan suatu fenomena atau kejadian secara apa adanya. Hasil yang diperoleh dalam penelitian ini bahwa aktor utama dalam kegiatan pengelolaan transportasi publik perkotaan yaitu pemerintah (Dinas Perhubungan Komunikasi dan Informatika Kota Pekanbaru. Diperlukan keterlibatan aktor diluar pemerintah dalam melakukan kegiatan pengelolaan transportasi publik perkotaan (Bus Trans Metro Pekanbaru agar hasil yang dicapai terlaksana secara optimal. Kata Kunci : Angkutan Perkotaan, Aktor pelaksana, pengelolaan transportasi publik perkotaan.

  7. Sistem Informasi Penampil Pengumuman Fakultas Teknik Universitas Diponegoro

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    Fajar Yogi Hernawan

    2017-01-01

    Full Text Available Abstract - Engineering Faculty is the biggest faculty with the highest number of departements and students in the Diponegoro University. The idea made SIPP (System Information Viewer Announcements Faculty of Engineering, University of Diponegoro appears is to help disseminate information and stories of pride born from Engineering Faculty to become the impetus and motivation for more achievement. SIPP maked with 5(five stages: requirement, analysis, design, implementation, testing. SIPP is built using the programming language PHP, HTML, CSS, Bootstrap, Javascript, and MySQL database. SIPP is expected to convey information and the pride stories of the Engineering Faculty in the multimedia. The output of the SIPP is the information shown via LCD TV screen ratio of 16: 9 which blend of images, video and running text. SIPP expected to be implemented in the lobby Engineering Faculty dean and in every department in it. Users SIPP is divided into 2 (two they are admin faculty as the main admin and admin department as sub-admin. SIPP tested with 2 (two test that is functionality testing by black box and performance testing with performance-analyzer application. With the implementation of SIPP environment Faculty of Engineering will be an additional alternative for the community Faculty of Engineering to obtain information. Keywords - Information, SIPP, multimedia, Engineering Faculty.   Intisari – Fakultas Teknik adalah fakultas dengan jumlah jurusan dan mahasiswa terbanyak di Universitas Diponegoro. Gagasan dibuatnya SIPP (Sistem Informasi Penampil Pengumuman Fakultas Teknik Universitas Diponegoro muncul adalah untuk membantu menyebarkan informasi dan cerita kebanggaan dari Fakultas Teknik yang menjadi dorongan dan motivasi untuk lebih berprestasi. SIPP dibuat dengan 5(lima tahap : rencana kebutuhan, analisis kebutuhan, perancangan desain, perancangan sistem, dan pengujian. SIPP dibangun menggunakan bahasa pemrograman PHP, HTML, CSS, Bootstrap

  8. Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex.

    Science.gov (United States)

    Gevorkyan-Airapetov, Lada; Zohary, Keren; Popov-Celeketic, Dusan; Mapa, Koyeli; Hell, Kai; Neupert, Walter; Azem, Abdussalam; Mokranjac, Dejana

    2009-02-20

    The TIM23 complex is the major translocase of the mitochondrial inner membrane responsible for the import of essentially all matrix proteins and a number of inner membrane proteins. Tim23 and Tim50, two essential proteins of the complex, expose conserved domains into the intermembrane space that interact with each other. Here, we describe in vitro reconstitution of this interaction using recombinantly expressed and purified intermembrane space domains of Tim50 and Tim23. We established two independent methods, chemical cross-linking and surface plasmon resonance, to track their interaction. In addition, we identified mutations in Tim23 that abolish its interaction with Tim50 in vitro. These mutations also destabilized the interaction between the two proteins in vivo, leading to defective import of preproteins via the TIM23 complex and to cell death at higher temperatures. This is the first study to describe the reconstitution of the Tim50-Tim23 interaction in vitro and to identify specific residues of Tim23 that are vital for the interaction with Tim50.

  9. ANALISA SUMBER DAYA MANUSIA TEKNOLOGI INFORMASI MENGGUNAKAN KERANGKA KERJA COBIT 4.1” (STUDI KASUS : UNIT PELAKSANA TEKNIS TELEMATIKA UNIVERSITAS PEMBANGUNAN NASIONAL “VETERAN” JAWA TIMUR

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    Mohammad Idhom

    2016-08-01

    Full Text Available Pengelolaan sumber daya manusia merupakan proses dan struktur hubungan yang mengendalikan dan mengarahkan suatu organisasi perusahaan dalam mencapai tujuan organisasi dengan menambahkan nilai agar teknologi informasi dan prosesnya dapat diseimbangkan dengan resikonya. Diperlukan sebuah evaluasi sumber daya manusia dibidang teknologi informasi untuk mengetahui sejauh mana tingkatan pengelolaan terhadap sumber daya manusia di Unit Pelaksana Teknis Telematika saat ini. Sumber daya manusia di bidang teknologi informasi pada Unit Pelaksana Teknis Telematika membutuhkan pengembangan dan pengelolaan sesuai dengan harapan organisasi. Melihat terbatasnya sumber daya manusia di bidang teknologi informasi pada Unit Pelaksana Teknis Telematika sangat terbatas sehingga kegiatan operasional masih belum efektif dan memenuhi sasaran yang diharapkan. Melihat kondisi organisasi yang mengalami terbatas pada sumber daya manusia di bidang teknologi informasi dilakukan evaluasi secara detail dengan menggunakan COBIT 4.1.Dalam melakukan evaluasi sumber daya manusia dengan menggunakan kerangka kerja COBIT  yang berfokus pada Domain PO7 diharapkan dapat memberikan acuan dan perbaikan yang lebih efektif terhadap organisasi ke depannya.

  10. KUALITAS JASA UNIT PELAKSANA TEKNIS PENGUJIAN SERTIFIKASI MUTU BARANG-LEMBAGA TEMBAKAU JEMBER

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    Shinta Setiadevi

    2015-03-01

    Full Text Available This study aims to 1 analyze the methods and the customer satisfaction measurement results; 2 analyze the satisfaction of customer based on alternatives method by using Servqual approach and EPA; 3 Analyze the comparison between method and the customer satisfaction measurement results; 4 formulate recommendations for improvement of measurement methods and results of customer satisfaction in the Technical Implementation Unit Testing Certification-Institute for Product Quality Tobacco Jember. The processing of the data in this study was used the analysis of Service Quality (Servqual and Expectation-Performance Analysis (EPA. The results of this study including: 1 Attributes which are considered sufficient by the IKM UPT measurement result  are nine attributes: the effectiveness and efficiency of service, courtesy, friendliness, and obtain justice and other services; 2 Attribute selected as a top priority improvements based on EPA method is the availability of equipment and the latest technology; 3 Methods and results of measuring the level of customer satisfaction can be compared based on: the number of dimensions and attributes of service; outputs and implications of measurement methods; measurement results; 4 Recommendations for improvement, the management should renew equipment and the latest technology in testing and calibration laboratories, and increase equipment and the latest technology at the service of fumigation.Keywords: EPA, service quality, servqual, UPT PSMB-LT JemberABSTRAKPenelitian ini bertujuan 1 menganalisis metode dan hasil pengukuran indek kepuasan masyarakat; 2 menganalisis tingkat kepuasan pelanggan berdasarkan alternatif metode melalui pendekatan Servqual dan EPA; 3 menganalisis perbandingan antara metode dan hasil pengukuran kepuasan pelanggan; 4 merumuskan rekomendasi perbaikan metode dan hasil pengukuran kepuasan pelanggan pada Unit Pelaksana Teknis Pengujian Sertifikasi Mutu Barang-Lembaga Tembakau Jember. Pengolahan

  11. PENGARUH IKLIM ORGANISASI TERHADAP PRODUKTIVITAS KERJA DI UNIT PELAKSANA TEKNIS KURIKULUM KECAMATAN JASINGA KABUPATEN BOGOR

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    Ayi Karyana

    2013-03-01

    Full Text Available The research analyzed the influence of organizational climate dimension on the work productivity at the Local Technical Service Unit (UPTK for Pre-Elementary and Elementary Education in the Jasinga Sub District of Bogor District. The research used explanatory survey method. Purposive sampling was the technique used to obtained samples. Data were collected by means of questionnaires, interviews and observations. The questionnaires were given to 75 people at the UPTK and they were all returned. The method used to analyze the data is path analysis. Statistical result showed that the variable dimension of the organizational climate has positive and significant impact on the productivity. The UPTK in the Jasinga Sub District of Bogor was totality consistent in giving meaning to the nature of conducive organizational climate. But in order to increase the effectivity and efficiency of the work productivity, it is necessary to socialize the organizations vision and mission, to increase the intensity of the communication, to share responsibility on everybody, to motivate the human resource involved in the job, to encourage reward and punishment, and to provide technological facilities needed to support the organization. Penelitian ini menganalisis pengaruh dimensi iklim organisasi terhadap produktivitas kerja di Unit Pelaksana Teknis Kurikulum (UPTK Kecamatan Jasinga Kabupaten Bogor. Metode penelitian yang digunakan adalah metode survei eksplanatori. Teknik sampling yang digunakan adalah purposive sampling dengan pertimbangan dan bertujuan tertentu. Prosedur pengumpulan data dilakukan dengan penyebaran angket, wawancara dan observasi. Angket disebarkan kepada 75 orang pada UPTK Kecamatan Jasinga, dan angket kembali semuanya. Metode analisis data yang digunakan penulis adalah analisis jalur. Hasil pengujian statistik menunjukkan bahwa dimensi variabel iklim organisasi berpengaruh positif dan signifikan terhadap produktivitas kerja. UPTK Kecamatan Jasinga

  12. MINAT BACA MAHASISWA FAKULTAS EKONOMI UNIVERSITAS PENGARUH PELAYANAN PERPUSTAAAN FAKULTAS EKONOMI DAN LINGKUNGAN SOSIAL TERHADAP NEGERI SEMARANG

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    Tahan Widodo

    2015-11-01

    Full Text Available Pelayanan Perpustakaan dan Lingkungan Sosial merupakan faktor yang mempengaruhi minat baca mahasiswa. Dari hasil observasi, ternyata minat baca mahasiswa Fakultas Ekonomi Universitas Negeri Semarang masih rendah yang dibuktikan dengan laporan kunjungan mahasiswa di perpustakaan Fakultas Ekonomi Universitas Negeri Semarang pada semester genap tahun 2013 dan 2014. Adapun tujuan dalam penelitian ini adalah: Adakah pengaruh pelayanan perpustakaan dan lingkungan sosial terhadap minat baca mahasiswa Fakultas Ekonomi Universitas Negeri Semarang, seberapa besar pengaruh pelayanan perpustakaan dan lingkungan sosial terhadap minat baca mahasiswa Fakultas Ekonomi Universitas Negeri Semarang. Populasi dalam penelitian ini adalah seluruh mahasiswa Fakultas Ekonomi yang berjumlah 4030 mahasiswa, jumlah sampel dalam penelitian ini ditentukan dengan menggunakan rumus Slovin diperoleh sebanyak 98 responden. teknik pengambilan sampel menggunakan Stratifield Proportional random sampling. Metode analisis data menggunakan deskipsi presentase, regresi berganda, uji F, uji t, koefisien determinasi simultan (R2 dan koefisien determinasi parsial (r2. Simpulan dari penelitian ini adalah ada pengaruh positif baik secara parsial maupun simultan pelayanan perpustakaan dan lingkungan sosial terhadap minat baca mahasiswa Fakultas Ekonomi Universitas Negeri Semarang. Saran yang diberikan dalam penelitian ini adalah sebaiknya petugas perpustakaan di Fakultas Ekonomi untuk menambah jumlah petugas perpustakaan dan menambah jumlah koleksi buku terutama koleksi buku pelajaran kuliah agar pelayanan menjadi lebih cepat dan mudah serta menarik mahasiswa untuk berkunjung ke perpustakaan sehingga minat baca mahasiswa akan lebih meningkat lagi. Melihat kondisi lingkungan sosial yang kondusif, alangkah baiknya mahasiswa meluangkan waktunya untuk kegiatan membaca selain kegiatan belajar yang lain. Library service and social environment are factor that effect students reading interest. The

  13. Tim Berners-Lee during the WSIS

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Tim Berners-Lee stands in front of the first web server at the Geneva Palexpo during the World Summit on the Information Society (WSIS) in 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  14. Analisis Tata Kelola Teknologi Informasi Menggunakan Kerangka Kerja COBIT 4.1 pada Fakultas Teknik Undip

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    Arini Arumana

    2014-06-01

    Full Text Available Peran teknologi informasi dalam suatu instansi sudah tidak dapat dielakkan lagi, mengingat perkembangannya yang begitu pesat seiring berjalannya waktu. Namun masalah yang sering terjadi di instansi adalah penggunaan teknologi informasi yang kadang tidak sesuai dengan harapan. Oleh karena itu diperlukan tata kelola terhadap penggunaan teknologi informasi yang biasa disebut dengan IT Governance. Fakultas teknik UNDIP adalah salah satu fakultas yang dalam operasionalnya sangat mengandalkan teknologi informasi, baik dalam aktifitas belajar mengajar maupun dalam menjalankan operasional bisnis. Kondisi sekarang di Fakultas Teknik sendiri tidak terdapat suatu indikator yang dapat menyatakan bahwa kinerja TI yang berjalan telah sesuai dengan visi dan misi Fakultas Teknik, oleh karena itu perlu dilakukan analisis tata kelola teknologi informasi, guna mengetahui performa TI sekarang sesuai dengan yang diharapkan oleh managemen atau tidak. Hasil dari analisis ini berupa tingkat kematangan tata kelola TI yang mecerminkan kondisi tata kelola TI di Fakultas Teknik dengan mengacu pada maturity level yang disediakan kerangka kerja COBIT 4.1, yakni dari level 0 (non-existent sampai 5 (optimized. Berdasarkan analisis yang dilakukan, secara garis besar kondisi kematangan tata kelola TI Fakultas Teknik berada pada level 2 yakni repeatable but intuitive. Kondisi ini mengacu pada beberapa kelemahan dalam proses-proses TI yang berjalan, diantaranya penetapan dan dokumentasi tindakan, kebijakan dan prosedur yang minim, serta tidak tersedianya service level yang disetujui bersama.

  15. Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei

    Science.gov (United States)

    Smith, Joseph T.; Singha, Ujjal K.; Misra, Smita

    2018-01-01

    ABSTRACT The small Tim proteins belong to a group of mitochondrial intermembrane space chaperones that aid in the import of mitochondrial inner membrane proteins with internal targeting signals. Trypanosoma brucei, the protozoan parasite that causes African trypanosomiasis, possesses multiple small Tim proteins that include homologues of T. brucei Tim9 (TbTim9) and Tim10 (TbTim10) and a unique small Tim that shares homology with both Tim8 and Tim13 (TbTim8/13). Here, we found that these three small TbTims are expressed as soluble mitochondrial intermembrane space proteins. Coimmunoprecipitation and mass spectrometry analysis showed that the small TbTims stably associated with each other and with TbTim17, the major component of the mitochondrial inner membrane translocase in T. brucei. Yeast two-hybrid analysis indicated direct interactions among the small TbTims; however, their interaction patterns appeared to be different from those of their counterparts in yeast and humans. Knockdown of the small TbTims reduced cell growth and decreased the steady-state level of TbTim17 and T. brucei ADP/ATP carrier (TbAAC), two polytopic mitochondrial inner membrane proteins. Knockdown of small TbTims also reduced the matured complexes of TbTim17 in mitochondria. Depletion of any of the small TbTims reduced TbTim17 import moderately but greatly hampered the stability of the TbTim17 complexes in T. brucei. Altogether, our results revealed that TbTim9, TbTim10, and TbTim8/13 interact with each other, associate with TbTim17, and play a crucial role in the integrity and maintenance of the levels of TbTim17 complexes. IMPORTANCE Trypanosoma brucei is the causative agent of African sleeping sickness. The parasite’s mitochondrion represents a useful source for potential chemotherapeutic targets. Similarly to yeast and humans, mitochondrial functions depend on the import of proteins that are encoded in the nucleus and made in the cytosol. Even though the machinery involved in this

  16. Mast cell activation is enhanced by Tim1:Tim4 interaction but not by Tim-1 antibodies [version 2; referees: 2 approved

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    Binh Phong

    2016-07-01

    Full Text Available Polymorphisms in the T cell (or transmembrane immunoglobulin and mucin domain 1 (TIM-1 gene, particularly in the mucin domain, have been associated with atopy and allergic diseases in mice and human. Genetic- and antibody-mediated studies revealed that Tim-1 functions as a positive regulator of Th2 responses, while certain antibodies to Tim-1 can exacerbate or reduce allergic lung inflammation. Tim-1 can also positively regulate the function of B cells, NKT cells, dendritic cells and mast cells. However, the precise molecular mechanisms by which Tim-1 modulates immune cell function are currently unknown. In this study, we have focused on defining Tim-1-mediated signaling pathways that enhance mast cell activation through the high affinity IgE receptor (FceRI. Using a Tim-1 mouse model lacking the mucin domain (Tim-1Dmucin, we show for the first time that the polymorphic Tim-1 mucin region is dispensable for normal mast cell activation. We further show that Tim-4 cross-linking of Tim-1 enhances select signaling pathways downstream of FceRI in mast cells, including mTOR-dependent signaling, leading to increased cytokine production but without affecting degranulation.

  17. Heavy metal contamination in TIMS Branch sediments

    International Nuclear Information System (INIS)

    Pickett, J.B.

    1990-01-01

    The objective of this memorandum is to summarize results of previous sediment studies on Tims Branch and Steed's Pond conducted by Health Protection (HP) and by the Savannah River Laboratory (SRL) in conjunction with Reactor Materials Engineering ampersand Technology (RMET). The results for other heavy metals, such as lead, nickel, copper, mercury, chromium, cadmium, zinc, and thorium are also summarized

  18. Pemanfaatan Jurnal Elektronik oleh Mahasiswa Fakultas Kedokteran Universitas Hasanuddin

    Directory of Open Access Journals (Sweden)

    Harisyah Harisyah

    2015-06-01

    Full Text Available Jurnal merupakan referensi yang paling sering digunakan sebagai dasar dalam melakukan penelitian di perguruan tinggi, karena materi-materi yang dipublikasikan merupakan materi terkini dan merupakan hasil temuan atau hasil penelitian. Pada saat sekarang ini, munculnya jurnal elektronik mengakibatkan perpustakaan lebih memilih untuk berlangganan jurnal elektronik dibanding dengan media cetak. Hal ini dikarenakan jurnal elektronik lebih mudah diakses dibandingkan dengan jurnal cetak. UPT Perpustakaan Universitas Hasanuddin merupakan salah satu perpustakaan perguruan tinggi yang melanggan jurnal elektronik. Akan tetapi, jurnal elektronik yang dilanggan oleh UPT Perpustakaan Universitas Hasanuddin belum dimanfaatkan secara merata oleh mahasiswa khususnya Mahasiswa Fakultas Kedokteran Universitas Hasanuddin. Mahasiswa tidak memanfaatkan jurnal elektronik tersebut bukan dikarenakan mereka tidak membutuhkan jurnal elektronik yang telah dilanggan. Akan tetapi, sebahagian besar dari mahasiswa  belum mengetahui adanya jurnal elektronik yang telah dilanggan oleh UPT Perpustakaan Universitas Hasanuddin. Abstract :  Journal is one of information forms. It is often used as a primary source to research, mostly in higher education. Journal, as many defined it, consists of contemporary thoughts and knowledge, and research findings as well. Nowadays, electronic journals are considered as the main option for many higher institutions to subscribe compared to its printed form. It is due to the easiness and accessable usage. UPT Perpustakaan Hasanuddin (Hasanuddin University Library is one of those academic libraries that has been subscribed electronic journals. Nevertheless, those electronic journals were lack of usage by degree medical students. The main reason was the lack of promotion or dissemination by the library.

  19. Penerapan Teknologi Cloud Computing Di Universitas Studi Kasus: Fakultas Teknologi Informasi Ukdw

    OpenAIRE

    Kurniawan, Erick

    2015-01-01

    Teknologi Cloud Computing adalah paradigma baru dalam penyampaian layanan komputasi. Cloud Computing memiliki banyak kelebihan dibandingkan dengan sistem konvensional. Artikel ini membahas tentang arsitektur cloud computing secara umum dan beberapa contoh penerapan layanan cloud computing beserta manfaatnya di lingkungan universitas. Studi kasus yang diambil adalah penerapan layanan cloud computing di Fakultas Teknologi Informasi UKDW.

  20. Evaluasi Soft Skills dalam Pembelajaran Mahasiswa Baru di Fakultas Teknologi Pertanian Universitas Udayana

    OpenAIRE

    Arnata, I Wayan; Surjoseputro, Sutarjo

    2014-01-01

    : Penelitian ini dilakukan dengan tujuan untuk mengevaluasi atribut soft skills yang dimiliki oleh mahasiswa baru Fakultas Teknologi Pertanian Universitas Udayana. Penelitian dilakukan dengan menggunakan desain pretest-posttest menggunakan kuesioner yang berisi atribut-atribut soft skills dan penilaian kemampuan pribadi. Dari hasil evaluasi terhadap pengembangan atribut soft skills diperoleh bahwa kemampuan soft skills yang dimiliki oleh mahasiswa baru setelah mengikuti pelatihan semuanya men...

  1. TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection.

    Science.gov (United States)

    Wang, Jing; Qiao, Luhua; Hou, Zhouhua; Luo, Guangxiang

    2017-01-15

    Human TIM and TAM family proteins were recently found to serve as phosphatidylserine (PS) receptors which promote infections by many different viruses, including dengue virus, West Nile virus, Ebola virus, Marburg virus, and Zika virus. In the present study, we provide substantial evidence demonstrating that TIM-1 is important for efficient infection by hepatitis C virus (HCV). The knockdown of TIM-1 expression significantly reduced HCV infection but not HCV RNA replication. Likewise, TIM-1 knockout in Huh-7.5 cells remarkably lowered HCV cell attachment and subsequent HCV infection. More significantly, the impairment of HCV infection in the TIM-1 knockout cells could be restored completely by ectopic expression of TIM-1 but not TIM-3 or TIM-4. Additionally, HCV infection and cell attachment were inhibited by PS but not by phosphatidylcholine (PC), demonstrating that TIM-1-mediated enhancement of HCV infection is PS dependent. The exposure of PS on the HCV envelope was confirmed by immunoprecipitation of HCV particles with a PS-specific monoclonal antibody. Collectively, these findings demonstrate that TIM-1 promotes HCV infection by serving as an attachment receptor for binding to PS exposed on the HCV envelope. TIM family proteins were recently found to enhance infections by many different viruses, including several members of the Flaviviridae family. However, their importance in HCV infection has not previously been examined experimentally. The TIM family proteins include three members in humans: TIM-1, TIM-3, and TIM-4. The findings derived from our studies demonstrate that TIM-1, but not TIM-3 or TIM-4, promotes HCV infection by functioning as an HCV attachment factor. Knockout of the TIM-1 gene resulted in a remarkable reduction of HCV cell attachment and infection. PS-containing liposomes blocked HCV cell attachment and subsequent HCV infection. HCV particles could also be precipitated with a PS-specific monoclonal antibody. These findings suggest that TIM-1

  2. Analisis Persepsi Leadership dan Kewirausahaan dalam Mencapai Visi Teacherprenuership dan Entrepreneurship (Studi Kasus Mahasiswa Fakultas Agama Islam Universitas Muhammadiyah Magelang)

    OpenAIRE

    Ahwy Oktradiksa

    2015-01-01

    Penelitian ini bertujuan (1) untuk mengetahui persepsi leadership dalam mencapai visi teacherpreneurship dan entrepreneurship menurut mahasiswa Fakultas Agama Islam.(2) Untuk mengetahui analisis leadership dalam mencapai visi teacherpreneurship dan entrepreneurship di Fakultas Agama Islam. Penelitian ini adalah jenis penelitian lapangan studi kasus. Metode penelitian dengan analitis deskriptif, metode pengambilan sampel yang diambil dengan purposive sampling, teknik pengambilan data dengan me...

  3. Analisis Persepsi Leadership Dan Kewirausahaan Dalam Mencapai Visi Teacherprenuership Dan Entrepreneurship (Studi Kasus Mahasiswa Fakultas Agama Islam Universitas Muhammadiyah Magelang)

    OpenAIRE

    Oktradiksa, Ahwy

    2015-01-01

    Penelitian ini bertujuan (1) untuk mengetahui persepsi leadership dalam mencapai visi teacherpreneurship dan entrepreneurship menurut mahasiswa Fakultas Agama Islam.(2) Untuk mengetahui analisis leadership dalam mencapai visi teacherpreneurship dan entrepreneurship di Fakultas Agama Islam. Penelitian ini adalah jenis penelitian lapangan studi kasus. Metode penelitian dengan analitis deskriptif, metode pengambilan sampel yang diambil dengan purposive sampling, teknik p...

  4. Perbedaan Penggunaan Standar Baru Antropometri WHO-2006 terhadap Peningkatan Pengetahuan dan Penilaian Status Gizi pada Tenaga Gizi Pelaksana di Kota Banda Aceh Tahun 2009

    Directory of Open Access Journals (Sweden)

    Alfridsyah Alfridsyah

    2013-12-01

    Full Text Available Latar belakang: Pada tahun 2003, WHO merumuskan konsep Multicenter Growth References Study (MGRS yang dilakukan di 6 negara dengan jumlah sampel yang diambil sebanyak 8440 anak hidup di lingkungan sehat yang memungkinkan tumbuh sesuai potensi genetik. Riset Kesehatan Dasar (Riskesdas yang dilakukan secara serentak di 33 provinsi di Indonesia pada tahun 2007 dalam penilaian status gizi balita telah mengacu pada WHO 2006. Secara keseluruhan Provinsi NAD termasuk ke dalam 10 besar yang mempunyai masalah gizi. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan standar baru antropometri 2006 terhadap peningkatan pengetahuan dan penilaian status gizi pada Tenaga GiziPelaksana (TGP di Kota Banda Aceh tahun 2009. Metode: Rancangan penelitian ini merupakan metode analitik eksploratif dengan pendekatan Quasi Experimental Design, yang dilakukan pada 70 TGP dan dibagi ke dalam dua kelompok. Data yang dikumpulkan meliputi data primer dan sekunder. Analisis data menggunakan Independent T-Test dan DependentT-Test pada CI: 95%. Hasil: Hasil analisis Independent T-Test menunjukkan bahwa terdapat perbedaan yang signifikan antara pengetahuan (p = 0,000, sikap (p = 0,004, perilaku (p = 0,005 dan peningkatan PSG (p = 0,031 antara post test pada kelompok ceramah disertai diskusi dengan ceramah disertai praktik. Sedangkan hasil analisis Dependent T-Test menunjukkan adanya peningkatan yang signifi kan dari pre tes ke post tes terhadap kedua kelompok pada TGP dalam wilayah kerja Kota Banda Aceh. Kesimpulan: Metode ceramah disertai praktik dan metode ceramah disertai diskusi dapat meningkatkan pengetahuan, sikap, perilaku dan penilaian status gizi oleh TGP, pendidikan kesehatan penilaian status gizimenggunakan standar antropometri baru WHO-2006 dengan metode ceramah disertai praktik lebih efektif dibandingkan metode ceramah disertai diskusi, dan ada pengaruh yang signifi kan penggunaan standar antropometri baru WHO-2006 terhadap peningkatan pengetahuan

  5. Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis

    Directory of Open Access Journals (Sweden)

    Robinson Melvin L

    2005-07-01

    Full Text Available Abstract Background The Cajal body (CB is a nuclear suborganelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs, which are vital for pre-mRNA splicing. Newly imported Sm-class snRNPs traffic through CBs, where the snRNA component of the snRNP is modified, and then target to other nuclear domains such as speckles and perichromatin fibrils. It is not known how nascent snRNPs localize to the CB and are released from this structure after modification. The marker protein for CBs, coilin, may play a role in snRNP biogenesis given that it can interact with snRNPs and SMN, the protein mutated in Spinal Muscular Atrophy. Loss of coilin function in mice leads to significant viability and fertility problems and altered CB formation. Results In this report, we identify a minor isoform of the mitochondrial Tim50, Tim50a, as a coilin interacting protein. The Tim50a transcript can be detected in some cancer cell lines and normal brain tissue. The Tim50a protein differs only from Tim50 in that it contains an additional 103 aa N-terminal to the translation start of Tim50. Importantly, a putative nuclear localization signal is found within these 103 residues. In contrast to Tim50, which localizes to the cytoplasm and mitochondria, Tim50a is strictly nuclear and is enriched in speckles with snRNPs. In addition to coilin, Tim50a interacts with snRNPs and SMN. Competition binding experiments demonstrate that coilin competes with Sm proteins of snRNPs and SMN for binding sites on Tim50a. Conclusion Tim50a may play a role in snRNP biogenesis given its cellular localization and protein interaction characteristics. We hypothesize that Tim50a takes part in the release of snRNPs and SMN from the CB.

  6. PEMBUATAN MODEL PROFIL MAHASISWA FAKULTAS TEKNIK UNIVERSITAS PANCASILA

    Directory of Open Access Journals (Sweden)

    Paryudi Paryudi

    2009-01-01

    Full Text Available Promotion is a must for a university to get students. With the innocence of the promotion team about the existing student profile, it will cause the team does not know which segment should be the promotion target. The consequence is that the promotion cost will be higher. In order to have a better promotion, we can use direct marketing method. In this method, a profile model of the existing students must be first created. With this profile model, promotion team can focus the promotion only to candidate student match with the model. The advantages of this method are: promotion cost can be reduced, response rate increase, and profit also increase. In order to create a model in direct marketing, we need previous promotion data. Since previous promotion data is not available, two methods in creating preliminary models are proposed. Next, the preliminary models will be tested using data mining software available in the market. Model with minimal accuracy of 75% will be chosen. If there are more than one model with minimal accuracy of 75%, then model with the highest accuracy will be chosen. Abstract in Bahasa Indonesia: Promosi merupakan suatu keharusan bagi sebuah universitas untuk mendapatkan mahasiswa. Dengan masih awamnya tim promosi terhadap profil mahasiswa yang sudah ada, maka tim promosi melakukan promosi tanpa melihat segmen pasar yang harus dituju. Konsekuensinya adalah biaya promosi menjadi lebih mahal. Untuk melakukan promosi dengan lebih baik, dapat menggunakan metode direct marketing. Pada metode ini, model profil dari mahasiswa yang sudah ada harus dibuat terlebih dulu. Dengan menggunakan model profil ini, tim promosi dapat memfokuskan promosi hanya pada calon-calon mahasiswa yang sesuai dengan model. Keuntungan dari metode promosi ini adalah biaya promosi dapat dikurangi, tingkat respon meningkat, dan keuntungan juga meningkat. Untuk membuat model pada direct marketing dibutuhkan data dari promosi sebelumnya. Karena data promosi

  7. Tim Berners-Lee and Kofi Annan during the WSIS

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  8. Tim Berners-Lee and Kofi Annan during the WSIS

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee, W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  9. Characterizing Functional Domains for TIM-Mediated Enveloped Virus Entry

    Science.gov (United States)

    Moller-Tank, Sven; Albritton, Lorraine M.; Rennert, Paul D.

    2014-01-01

    ABSTRACT T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance entry of Ebola virus (EBOV) and other viruses by binding PtdSer on the viral envelope, concentrating virus on the cell surface, and promoting subsequent internalization. The PtdSer-binding activity of the immunoglobulin-like variable (IgV) domain is essential for both virus binding and internalization by TIM-1. However, TIM-3, whose IgV domain also binds PtdSer, does not effectively enhance virus entry, indicating that other domains of TIM proteins are functionally important. Here, we investigate the domains supporting enhancement of enveloped virus entry, thereby defining the features necessary for a functional PVEER. Using a variety of chimeras and deletion mutants, we found that in addition to a functional PtdSer-binding domain PVEERs require a stalk domain of sufficient length, containing sequences that promote an extended structure. Neither the cytoplasmic nor the transmembrane domain of TIM-1 is essential for enhancing virus entry, provided the protein is still plasma membrane bound. Based on these defined characteristics, we generated a mimic lacking TIM sequences and composed of annexin V, the mucin-like domain of α-dystroglycan, and a glycophosphatidylinositol anchor that functioned as a PVEER to enhance transduction of virions displaying Ebola, Chikungunya, Ross River, or Sindbis virus glycoproteins. This identification of the key features necessary for PtdSer-mediated enhancement of virus entry provides a basis for more effective recognition of unknown PVEERs. IMPORTANCE T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members are recently identified phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance virus entry by binding the phospholipid, PtdSer, present on the viral

  10. Tim Berners-Lee receives the Millennium Technology Prize

    CERN Multimedia

    2004-01-01

    On 15 April, for his invention of the Web, Tim Berners-Lee was awarded the first ever Millennium Technology Prize by the Finnish Technology Award Foundation, which recognises technological innovations of lasting benefit to society. "Tim Berners-Lee's invention perfectly encapsulates the spirit of the Prize. The Web is encouraging new types of social networks, contributing to transparency and democracy, and opening up new avenues for information management and business development," underlined Pekka Tarjanne, chairman of the jury and former Secretary-General of the International Telecommunication Union (ITU). Tim Berners-Lee is congratulated by Jukka Valtasaari, Finland's Ambassador to the United States. Tim Berners-Lee created the first server, browser and editor, the HTML code, the URL address and the HTTP transmission protocol at CERN in 1990. CERN released the Web into the public domain in 1993. Tim Berners-Lee is currently head of the World Wide Web Consortium, managed by ERCIM (Europe...

  11. Project TIMS (Teaching Integrated Math/Science)

    Science.gov (United States)

    Edwards, Leo, Jr.

    1993-01-01

    The goal of this project is to increase the scientific knowledge and appreciation bases and skills of pre-service and in-service middle school teachers, so as to impact positively on teaching, learning, and student retention. This report lists the objectives and summarizes the progress thus far. Included is the working draft of the TIMS (Teaching Integrated Math/Science) curriculum outline. Seven of the eight instructional subject-oriented modules are also included. The modules include informative materials and corresponding questions and educational activities in a textbook format. The subjects included here are the universe and stars; the sun and its place in the universe; our solar system; astronomical instruments and scientific measurements; the moon and eclipses; the earth's atmosphere: its nature and composition; and the earth: directions, time, and seasons. The module not included regards winds and circulation.

  12. Tim Peake and Britain's road to space

    CERN Document Server

    Seedhouse, Erik

    2017-01-01

    This book puts the reader in the flight suit of Britain’s first male astronaut, Tim Peake. It chronicles his life, along with the Principia mission and the down-to-the-last-bolt descriptions of life aboard the ISS, by way of the hurdles placed by the British government and the rigors of training at Russia’s Star City military base. In addition, this book discusses the learning curves required in astronaut and mission training and the complexity of the technologies required to launch an astronaut and keep them alive for months on end. This book underscores the fact that technology and training, unlike space, do not exist in a vacuum; complex technical systems, like the ISS, interact with the variables of human personality, and the cultural background of the astronauts. .

  13. TIM-1 signaling in B cells regulates antibody production

    International Nuclear Information System (INIS)

    Ma, Juan; Usui, Yoshihiko; Takeda, Kazuyoshi; Harada, Norihiro; Yagita, Hideo; Okumura, Ko; Akiba, Hisaya

    2011-01-01

    Highlights: → TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. → Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. → TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo. -- Abstract: Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other hand, TIM-1 ligand was constitutively expressed on B cells and inducible on anti-CD3 + anti-CD28-stimulated CD4 + T cells. In vitro stimulation of activated B cells by anti-TIM-1 mAb enhanced proliferation and expression of a plasma cell marker syndecan-1 (CD138). We further examined the effect of TIM-1 signaling on antibody production in vitro and in vivo. Higher levels of IgG2b and IgG3 secretion were detected in the culture supernatants of the anti-TIM-1-stimulated B cells as compared with the control IgG-stimulated B cells. When immunized with T-independent antigen TNP-Ficoll, TNP-specific IgG1, IgG2b, and IgG3 Abs were slightly increased in the anti-TIM-1-treated mice. When immunized with T-dependent antigen OVA, serum levels of OVA-specific IgG2b, IgG3, and IgE Abs were significantly increased in the anti-TIM-1-treated mice as compared with the control IgG-treated mice. These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation.

  14. TIM-1 signaling in B cells regulates antibody production

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Juan [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Usui, Yoshihiko [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku-ku, Tokyo 160-0023 (Japan); Takeda, Kazuyoshi [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Harada, Norihiro [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Department of Respiratory Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Research Institute for Diseases of Old Ages, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Yagita, Hideo; Okumura, Ko [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Akiba, Hisaya, E-mail: hisaya@juntendo.ac.jp [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)

    2011-03-11

    Highlights: {yields} TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. {yields} Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. {yields} TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo. -- Abstract: Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other hand, TIM-1 ligand was constitutively expressed on B cells and inducible on anti-CD3{sup +} anti-CD28-stimulated CD4{sup +} T cells. In vitro stimulation of activated B cells by anti-TIM-1 mAb enhanced proliferation and expression of a plasma cell marker syndecan-1 (CD138). We further examined the effect of TIM-1 signaling on antibody production in vitro and in vivo. Higher levels of IgG2b and IgG3 secretion were detected in the culture supernatants of the anti-TIM-1-stimulated B cells as compared with the control IgG-stimulated B cells. When immunized with T-independent antigen TNP-Ficoll, TNP-specific IgG1, IgG2b, and IgG3 Abs were slightly increased in the anti-TIM-1-treated mice. When immunized with T-dependent antigen OVA, serum levels of OVA-specific IgG2b, IgG3, and IgE Abs were significantly increased in the anti-TIM-1-treated mice as compared with the control IgG-treated mice. These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation.

  15. Meet EPA Scientist Tim Shafer, Ph.D.

    Science.gov (United States)

    Tim Shafer earned his bachelor’s degree in biology and chemistry from Hope College in Holland, MI, in 1986 and his Ph.D. in pharmacology and environmental toxicology from Michigan State University in 1991.

  16. Response to Tim Barringer, A White Atlantic?

    Directory of Open Access Journals (Sweden)

    Kate Flint

    2009-11-01

    Full Text Available In my response to Tim Barringer’s piece, I emphasize the importance of extending one’s frame of reference when discussing transatlantic artistic connections to the consideration of as many different art forms as possible – including photography, and magazine and book illustrations – in order to get as full a picture as possible of the two-way flow in transatlantic artistic influences.This fuller picture notably extends the degree to which images of non-white subjects are seen to be in circulation. I also draw attention to the ways in which American and English artistic circles intersected outside as well as within these two countries, a point reinforced by looking at American women sculptors in Rome in the 1860s, paying particular attention to the work of the part African-American, part Native American sculptor, Edmonia Lewis. In her work can be seen a complex set of attitudes towards her subject matter that remind one forcefully of the many racial and cultural strands coming together in new American art.

  17. Tim Berners-Lee, World Wide Web inventor

    CERN Multimedia

    1994-01-01

    Former physicist, Tim Berners-Lee invented the World Wide Web as an essential tool for high energy physics at CERN from 1989 to 1994. Together with a small team he conceived HTML, http, URLs, and put up the first server and the first 'what you see is what you get' browser and html editor. Tim is now Director of the Web Consortium W3C, the International Web standards body based at INRIA, MIT and Keio University.

  18. Isotopic Ratios of Samarium by TIMS for Nuclear Forensic Application

    Energy Technology Data Exchange (ETDEWEB)

    Louis Jean, James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Inglis, Jeremy David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-08

    The isotopic ratio of Nd, Sm, and Gd can provide important information regarding fissile material (nuclear devices, reactors), neutron environment, and device yield. These studies require precise measurement of Sm isotope ratios, by either TIMS or MC-ICP-MS. There has been an increasing trend to measure smaller and smaller quantities of Sm bearing samples. In nuclear forensics 10-100 ng of Sm are needed for precise measurement. To measure sub-ng Sm samples using TIMS for nuclear forensic analysis.

  19. Perilaku Mahasiswa Dalam Meminimalisir Penggunaan Kantong Plastik Dan Styrofoam Di Fakultas Kesehatan Masyarakat Universitas Sumatera Utara Tahun 2017

    OpenAIRE

    Sihombing, Margaretha Pratiwi

    2017-01-01

    131000630 Penggunaan plastik dan styrofoam sebagai kemasan makanan merupakan perilaku yang menyebabkan kerusakan dan pencemaran lingkungan. Penggunaan plastik dan styrofoam meningkat secara signifikan dan banyak digunakan sehingga menyebabkan masalah kesehatan dan lingkungan. Penelitian ini bertujuan untuk mengetahui perilaku mahasiswa dalam meminimalisir penggunaan kantong plastik dan styrofoam di Fakultas Kesehatan Masyarakat Universitas Sumatera Utara tahun 2017. Je...

  20. HUBUNGAN ANTARA TIPE KEPRIBADIAN INTROVERT DAN EKSTROVERT DENGAN KEJADIAN STRES PADA KOASISTEN ANGKATAN TAHUN 2011 FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA

    Directory of Open Access Journals (Sweden)

    I Gede Suprayoga Sukmana Putra

    2015-04-01

    Full Text Available Stres merupakan salah satu masalah psikologis yang seringkali dijumpai di kalangan koasisten fakultas kedokteran. Sumber stres dapat bersifat internal maupun eksternal. Tipe kepribadian merupakan salah satu faktor yang memengaruhi munculnya stres. Tujuan dari penelitian ini adalah untuk mencari hubungan antara tipe kepribadian introvert dan ekstrovert dengan kejadian stres pada koasisten angkatan tahun 2011 Fakultas Kedokteran Universitas Udayana. Desain penelitian yang digunakan adalah cross sectional analitik. Pengambilan data dilakukan dengan menggunakan kuesioner yang disebar pada 62 koasisten angkatan tahun 2011 Fakultas Kedokteran Universitas Udayana. Analisis bivariat dilakukan dengan uji chi square menggunakan perangkat lunak SPSS 16.0. Jumlah responden yang memiliki kepribadian ekstrovert lebih banyak dibandingkan dengan yang introvert (56,5% vs 43,5% dan responden yang mengalami stres berjumlah 33 orang (53,2%. Analisis bivariat menunjukkan adanya hubungan yang signifikan antara tipe kepribadian introvert dan ekstrovert dengan kejadian stres (p = 0,000 [p < 0,05]. Dari hasil penelitian disimpulkan bahwa terdapat hubungan antara tipe kepribadian introvert dan ekstrovert dengan kejadian stres pada koasisten angkatan tahun 2011 Fakultas Kedokteran Universitas Udayana.    

  1. There are those who call it...TIM

    CERN Multimedia

    2007-01-01

    To boldly go where people can't... The Train Inspection Monorail, affectionately referred to as 'TIM,' will allow scientists, technicians and engineers to view and take measurements in the LHC tunnel when it is inaccessible to humans. TIM in the tunnel.Jean-Louis Grenard, who designed TIM's mechanical components, uses the portable remote control station to put the TIM through its paces at Point 1 in the LHC. Imagine being able to view parts of the LHC before people are allowed into the tunnel after the beam has been circulating...or to accurately measure the position of equipment in areas with the highest levels of radiation without risking human exposure. The Train Inspection Monorail, or 'TIM' to its closer friends, is a modular train that will run along the ceiling of the LHC tunnel, helping many groups on site to address the problems of inspecting, measuring and even handling equipment in the LHC when radiation levels and cryogenic hazards will restrict personnel access to the tunnel. TIM was developed ...

  2. HUBUNGAN ANTARA MENONTON IKLAN WECHAT DI TELEVISI DAN MINAT PENGGUNA SMARTPHONE DALAM MENGGUNAKAN APLIKASI WECHAT PADA MAHASISWA FAKULTAS ILMU SOSIAL DAN ILMU POLITIK UNIVERSITAS HASANUDDIN

    OpenAIRE

    ANIS, ANDI MOHAMMAD MENTARIFAJAR

    2013-01-01

    2013 ANDI MOHAMMAD MENTARIFAJAR ANIS. Hubungan Antara Menonton Iklan WeChat di Televisi dan Minat Pengguna Smartphone dalam Menggunakan Aplikasi WeChat pada Mahasiswa Fakultas Ilmu Sosial dan Ilmu Politik Universitas Hasanuddin (Dibimbing oleh Kahar dan Andi Subhan Amir). Penelitian ini bertujuan untuk mengetahui minat menonton iklan WeChat mahasiswa Fakultas Ilmu Sosial dan Ilmu Politik Universitas Hasanuddin dan juga minat pengguna smartphone ter...

  3. Reconstituted TOM core complex and Tim9/Tim10 complex of mitochondria are sufficient for translocation of the ADP/ATP carrier across membranes.

    Science.gov (United States)

    Vasiljev, Andreja; Ahting, Uwe; Nargang, Frank E; Go, Nancy E; Habib, Shukry J; Kozany, Christian; Panneels, Valérie; Sinning, Irmgard; Prokisch, Holger; Neupert, Walter; Nussberger, Stephan; Rapaport, Doron

    2004-03-01

    Precursor proteins of the solute carrier family and of channel forming Tim components are imported into mitochondria in two main steps. First, they are translocated through the TOM complex in the outer membrane, a process assisted by the Tim9/Tim10 complex. They are passed on to the TIM22 complex, which facilitates their insertion into the inner membrane. In the present study, we have analyzed the function of the Tim9/Tim10 complex in the translocation of substrates across the outer membrane of mitochondria. The purified TOM core complex was reconstituted into lipid vesicles in which purified Tim9/Tim10 complex was entrapped. The precursor of the ADP/ATP carrier (AAC) was found to be translocated across the membrane of such lipid vesicles. Thus, these components are sufficient for translocation of AAC precursor across the outer membrane. Peptide libraries covering various substrate proteins were used to identify segments that are bound by Tim9/Tim10 complex upon translocation through the TOM complex. The patterns of binding sites on the substrate proteins suggest a mechanism by which portions of membrane-spanning segments together with flanking hydrophilic segments are recognized and bound by the Tim9/Tim10 complex as they emerge from the TOM complex into the intermembrane space.

  4. PERANCANGAN SISTEM INFORMASI PERPUSTAKAAN MENGGUNAKAN BARCODE PADA FAKULTAS ILMU KOMPUTER UNIVERSITAS LANCANG KUNING

    Directory of Open Access Journals (Sweden)

    Fery Wongso Fery Wongso

    2015-09-01

    Full Text Available Abstrak : Sistem informasi Perpustakaan merupakan unit kerja yang mengumpulkan, menyimpan, memelihara dan mengelola pemanfaatan koleksi bahan pustaka dengan menggunakan sistem .  Sistem informasi sudah banyak digunakan pada suatu tempat dengan berbagai macam teknologi dan sistem. Tujuan dari penulisan ini adalah untuk merancang sistem informasi perpustakaan yang ada pada Fakultas Ilmu Komputer Universitas Lancang Kuning PekanbaruAgar menjadi terkomputerisasi dan memudahkan bagian staf perpustakaan dalam mengolah data buku, data anggota, peminjaman buku dan pengembalian buku. agar cepat dan akurat dengan menggunakan suatu aplikasi PHP untuk dapat membantu dalam pengolahan data buku, data anggota, peminjaman buku dan proses pengembalian buku pada Fakultas Ilmu Komputer Universitas Lancang Kuning Pekanbaru. Abstract : Library Information Systems is a business unit that collect, store, preserve and manage the utilization of library collections using the system. The information system has been widely used in a place with a variety of technologies and systems. The purpose of this paper is to design a library of existing information systems at the Faculty of Computer Science University of Lancang Kuning PekanbaruIn order to be computerized and facilitate the passage of library staff in processing the data book, data members, borrowing books and returning books. to quickly and accurately using a PHP application to be able to assist in the processing of the data book, data members, borrowing books and the process of returning books at the Faculty of Computer Science University of Lancang Kuning Pekanbaru. Keywords : Information Systems, Computer Science Faculty Library

  5. IDENTIFIKASI TINGKAT KUALITAS PELAYANAN JASA PENDIDIKAN DENGANMENGGUNAKAN SERVQUALDI FAKULTAS TEKNIK UNIVERSITAS X

    Directory of Open Access Journals (Sweden)

    Chalis Fajri Hasibuan

    2017-04-01

    Full Text Available Persaingan di dalam dunia pendidikan dewasa ini semakin ketat, khususnya perguruan tinggi, bukan hanya perguruan tinggi dalam negeri saja yang menjadi pesaing tetapi juga perguruan tinggi luar negeri.Minat masyarakat Indonesia semakin tinggi terhadap perguruan tinggi luar negeri yang menawarkan kualitas jasa pendidikan yang lebih baik. Adapun tujuan dalam penelitian ini yaitu Mengukur tingkat kepuasan mahasiswa/i Fakultas Teknik Universitas X terhadap pelayanan jasa yang diberikan oleh Fakultas Teknik Universitas X. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan teknik survey.Metode yang digunakan adalah metode Servqual.Metode servqual digunakan untuk menentukan atribut serta mengukur kesenjangan (gap antara harapan dengan persepsi konsumen terhadap suatu pelayanan. Hasil penelitian diperoleh gap Dengan nilai terbesar yakni -0.9186 menunjukkan bahwa fasilitas yang diberikan belum sesuai dengan biaya uang kuliah yang dibayarkan oleh mahasiswa sedangkan Tingkat pendidikan Dosen yang mengajar di UMA sudah berpendidikan minimal S2 dengan gap yang bernilai positif sebesar 0.0679 yang mengindekasikan bahwa tingkat harapan yang ada pada mahasiswa lebih rendah dari kinerja yang diberikan oleh Universitas X.

  6. Analysis of TIMS performance subjected to simulated wind blast

    Science.gov (United States)

    Jaggi, S.; Kuo, S.

    1992-01-01

    The results of the performance of the Thermal Infrared Multispectral Scanner (TIMS) when it is subjected to various wind conditions in the laboratory are described. Various wind conditions were simulated using a 24 inch fan or combinations of air jet streams blowing toward either or both of the blackbody surfaces. The fan was used to simulate a large volume of air flow at moderate speeds (up to 30 mph). The small diameter air jets were used to probe TIMS system response in reaction to localized wind perturbations. The maximum nozzle speed of the air jet was 60 mph. A range of wind directions and speeds were set up in the laboratory during the test. The majority of the wind tests were conducted under ambient conditions with the room temperature fluctuating no more than 2 C. The temperature of the high speed air jet was determined to be within 1 C of the room temperature. TIMS response was recorded on analog tape. Additional thermistor readouts of the blackbody temperatures and thermocouple readout of the ambient temperature were recorded manually to be compared with the housekeeping data recorded on the tape. Additional tests were conducted under conditions of elevated and cooled room temperatures. The room temperature was varied between 19.5 to 25.5 C in these tests. The calibration parameters needed for quantitative analysis of TIMS data were first plotted on a scanline-by-scanline basis. These parameters are the low and high blackbody temperature readings as recorded by the TIMS and their corresponding digitized count values. Using these values, the system transfer equations were calculated. This equation allows us to compute the flux for any video count by computing the slope and intercept of the straight line that relates the flux to the digital count. The actual video of the target (the lab floor in this case) was then compared with a simulated target. This simulated target was assumed to be a blackbody at emissivity of .95 degrees and the temperature was

  7. ANALISIS KEPUASAN PENGGUNA JASA PEMELIHARAAN DAN PERBAIKAN ATAS PELAYANAN UPT-PP (UNIT PELAKSANA TEKNIS PEMELIHARAAN DAN PERBAIKAN POLITEKNIK NEGERI BALI

    Directory of Open Access Journals (Sweden)

    I Made Aryana

    2016-01-01

    Full Text Available ABSTRACT: PNBis avocational educationinstitution. Withvocationalpredicate,PNBhavediverse learningfacility. In order forthese assetsremainin top condition(ready to use, there should bea specialunit thathandlesmaintenance andrepairissues. UPT-PP (Unit Pelaksana Teknis Pemeliharaan dan Perbaikan isone of the unitsinPNBwhichhas a function asimplementingmaintenanceandrepairsof allassets, and all equipment usedin the activities ofthe learning process. UPT-PP has thefunctions andresponsibilitiesarequite heavyand vitalin supportingthe smoothlearning activitiesboth theory andpractice. This situation demandsUPT-PP shouldhavegoodhuman resources, competent, reliable andshould be supportedbythe provision ofhardwareandsoftwarethat isadequate. This studyaims to determinethe value ofservice usersatisfaction levelof maintenanceandrepair ofservices givenbyUPT-PP Politeknik Negeri Baliandidentify the factorsthat need attentionin order to increaseuser satisfactionwith the servicesUPT-PP Politeknik Negeri Bali. Retrieval of dataobtained from thespread ofthe questioner aboutfacts andrealityassociatedwith service qualityanduser expectationsUPT-PP Politeknik Negeri Bali. While the calculationof thecorrespondence between thelevel of quality anduser expectationsUPT-PP isthe comparison ofthe qualityweightwith the weight ofexpectations/interests. This conformity levelwillshow the level ofuser satisfactionwith the services. Results ofa descriptiveanalysis ofuser satisfactionwith the servicesUPT-PP can be determined bythe value ofthe conformity level. After analysis, the conformitylevelofeachdimensionis obtainedfromthe tangiblevalue81.08%, conformity level of reliability79.04%, conformity level of responsiveness to the valueof81.09%, theassurancedimensionwithvalue84.20% anddimensionsof empathywith the conformity value83.23%. Fromfivedimensions ofconformity level assessment between service qualityexpectationsof service usersUPT-PP Politeknik Negeri Bali is81

  8. PERILAKU KONSUMSI MIE INSTAN MAHASISWA FAKULTAS ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH DAN JURUSAN GIZI POLTEKKES KEMENKES PONTIANAK

    Directory of Open Access Journals (Sweden)

    Rochmawati Rochmawati

    2015-11-01

    Full Text Available Abstract: Instant Noodle Consumption Behavior Among Students Of Health Sciences Faculty Of Muhammadiyah University Pontianak And Nutrition Department Of Health Polytechnic Of Health Ministry Pontianak. This study aimed at determining the factors associated with instant noodle consumption behaviour among students of Health Sciences Faculty of Muhammadiyah University of Pontianak and Nutrition Department of Health Polytechnic of Health Ministry of Pontianak. Using cross-sectional design, this study employed 145 students as the samples and were selected by using simple random sampling. The statistical test used was chi-square test. The study revealed that there were no significant correlation of  nutritional knowledge (p = 1.000, PR = 1.004 with 95% CI = 0.712 to 1.415, food safety(p = 0.064, PR =0,646with 95% CI = 0.407 to 1.025, media exposure (p = 0.139, PR = 1.419 with 95% CI = 0.911 to 2.211, inhabitancy (p = 0.851, PR = 0.932 with 95% CI = 0.646 to 1.344 and instant noodles consumption behavior among students of Health Sciences Faculty of Muhammadiyah University Pontianak and Nutrition Department of Health Polytechnic of Health Ministry Pontianak. Abstrak : Perilaku Konsumsi Mie Instan Mahasiswa Fakultas Ilmu Kesehatan Universitas Muhammadiyah Dan Jurusan Gizi Poltekkes Kemenkes Pontianak. Tujuan penelitian yaitu untuk mengetahui faktor-faktor yang berhubungan dengan perilaku konsumsi mie instan pada mahasiswa  Fakultas Ilmu Kesehatan Universitas Muhammadiyah Pontianak dan Jurusan Gizi Poltekkes Kemenkes Pontianak. Jumlah sampel yaitu 145 orang dengan penentuan sampel secara Simple random sampling dan menggunakan desain penelitian cross sectional. Uji statistik yang digunakan adalah Chi-square. Hasil penelitian menunjukkan tidak terdapat hubungan yang bermakna antara pengetahuan gizi (p = 1,000, PR = 1,004 dengan CI 95% = 0,712-1,415, keamanan pangan (p = 0,064, PR = 0,646 dengan CI 95% =0,407-1,025, keterpaparan media (p = 0,139, PR = 1

  9. Thermal ionisation mass spectrometry (TIMS): what, how and why?

    International Nuclear Information System (INIS)

    Aggarwal, S.K.

    2002-01-01

    Thermal ionisation mass spectrometry (TIMS) is one of the oldest mass spectrometric techniques, which has been used for determining the isotopic composition and concentration of different elements using isotope dilution. In spite of the introduction of many other inorganic mass spectrometric techniques like spark source mass spectrometry (SSMS), glow discharge mass spectrometry (GDMS), inductively coupled plasma-mass spectrometry (ICP-MS), secondary ion mass spectrometry (SIMS), the TIMS technique plays the role of a definitive analytical methodology and still occupies a unique position in terms of its capabilities with respect to precision and accuracy as well as sensitivity

  10. Awards: New Year Knighthood for Tim Berners-Lee

    CERN Multimedia

    2004-01-01

    Tim Berners-Lee has been awarded his country's highest honour - a knighthood - in the UK's New Year Honours list for his work while at CERN on the World Wide Web. In the same honours list, Roger Cashmore has been made a Companion of the Order of St Michael and St George (CMG) "for his services to international co-operation in particle physics". Cashmore was CERN's Director for Collider Programmes from 1999-2003, and is now Principal of Brasenose College, Oxford. Tim Berners-Lee stands in front of the first web server at Palexpo during the World Summit on the Information Society.

  11. A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9

    International Nuclear Information System (INIS)

    Weyer, Philipp S. van de; Muehlfeit, Michael; Klose, Christoph; Bonventre, Joseph V.; Walz, Gerd; Kuehn, E. Wolfgang

    2006-01-01

    Tim-3 is a member of the TIM family of proteins (T-cell immunoglobulin mucin) involved in the regulation of CD4+ T-cells. Tim-3 is a T H 1-specific type 1 membrane protein and regulates T H 1 proliferation and the development of tolerance. Binding of galectin-9 to the extracellular domain of Tim-3 results in apoptosis of T H 1 cells, but the intracellular pathways involved in the regulatory function of Tim-3 are unknown. Unlike Tim-1, which is expressed in renal epithelia and cancer, Tim-3 has not been described in cells other than neuronal or T-cells. Using RT-PCR we demonstrate that Tim-3 is expressed in malignant and non-malignant epithelial tissues. We have cloned Tim-3 from an immortalized liver cell carcinoma line and identified a highly conserved tyrosine in the intracellular tail of Tim-3 (Y265). We demonstrate that Y265 is specifically phosphorylated in vivo by the interleukin inducible T cell kinase (ITK), a kinase which is located in close proximity of the TIM genes on the allergy susceptibility locus 5q33.3. Stimulation of Tim-3 by its ligand galectin-9 results in increased phosphorylation of Y265, suggesting that this tyrosine residue plays an important role in downstream signalling events regulating T-cell fate. Given the role of TIM proteins in autoimmunity and cancer, the conserved SH2 binding domain surrounding Y265 could represent a possible target site for pharmacological intervention

  12. Hubungan Stres dengan Kejadian Dismenore Primer pada Mahasiswi Pendidikan Dokter Fakultas Kedokteran Universitas Andalas

    Directory of Open Access Journals (Sweden)

    Diana Sari

    2015-05-01

    Full Text Available AbstrakDismenore primer merupakan nyeri menstruasi yang dijumpai tanpa kelainan yang nyata pada alat-alat genital. Lebih dari 50% wanita mengalami dismenore primer dan 15% diantaranya mengalami nyeri yang hebat.Tujuan penelitian ini adalah untuk menentukan hubungan tingkat stres dengan derajat dismenore primer. Penelitian dilakukan pada mahasiswi pendidikan dokter Fakultas Kedokteran Universitas Andalas angkatan 2009 dan 2010. Desain penelitian ini menggunakan cross sectional study dengan jumlah subjek 165 orang. Pengumpulan data dari responden dilakukan dengan wawancara terpimpin (pengisian kuesioner. Analisa statistik yang digunakan adalah uji chi-square dan uji koefisien korelasi sederhana. Uji chi-square menunjukan ada hubungan yang bermakna antara stres dengan kejadian dismenore primer dan uji statistik koefisien korelasi sederhana menunjukkan ada hubungan yang bermakna dengan korelasi agak lemah antara tingkat stres dengan derajat dismenore primer.Kata kunci: stres, dismenore primer, mahasiswi fakultas kedokteran AbstractPrimary dysmenorrhoea is menstrual pain founded without real abnormalities in genital organs. More than 50% woman experiance it and 15% had severe pain. The objective of this study was to determine relationship between stress and primary dysmenorrhoea. Research was executed to education medical female students medical faculty of Andalas University class of 2009 and 2010. This research use cross sectional study design with 165 subjects. Data was collected by guided interview. Statistic analysis use chi-square test and simple correlation test. Chi-square test show there is significant relationship between stress and primary dysmenorrhoea and simple coefficient test show there is weak correlation between stress levels and degree of primary dysmenorrhoea.Keywords: stress, primary dysmenorrhoea, female student of medical faculty

  13. Analisis Persepsi Leadership dan Kewirausahaan dalam Mencapai Visi Teacherprenuership dan Entrepreneurship (Studi Kasus Mahasiswa Fakultas Agama Islam Universitas Muhammadiyah Magelang

    Directory of Open Access Journals (Sweden)

    Ahwy Oktradiksa

    2015-06-01

    Full Text Available Penelitian ini bertujuan (1 untuk mengetahui persepsi leadership dalam mencapai visi teacherpreneurship dan entrepreneurship menurut mahasiswa Fakultas Agama Islam.(2 Untuk mengetahui analisis leadership dalam mencapai visi teacherpreneurship dan entrepreneurship di Fakultas Agama Islam. Penelitian ini adalah jenis penelitian lapangan studi kasus. Metode penelitian dengan analitis deskriptif, metode pengambilan sampel yang diambil dengan purposive sampling, teknik pengambilan data dengan metode observasi, wawancara dan kuisioner mengukur tingkat pemahaman. Hasil penelitian sebagai berikut : (1 Persepsi pada hakikatnya adalah proses kognitif yang dialami oleh setiap orang dalam memahami informasi tentang lingkungannya, merupakan suatu penafsiran yang unik terhadap situasi. Pandangan mahasiswa Fakultas Agama Islam Universitas Muhammadiyah Magelang tentang leadership/kepemimpinan dalam mewujudkan visi entreprenueship dan teacherprenuership sangatlah diperlukan karena suatu organisasi senantiasa menilai, baik sesama anggota maupun terhadap gaya yang diterapkan pemimpin, dan sebaliknya pemimpin memberi penilaian terhadap perilaku anggota. Sementara itu dalam kehidupan berorganisasi melakukan pengambilan keputusan yaitu dengan membuat pilihan dari dua alternatif atau lebih dimana semua keputusan menuntut penafsiran dan evaluasi terhadap informasi. (2 Berdasarkan hasil analisis persepsi yang dilakukan maka dapat dideksripsikan; (a Adanya persepsi leadership yang sifatnya berpengaruh positif berdasarkan indek persentase “setuju” dengan 6,57 % dan sangat setuju dengan 11,7 %, (b Adanya persepsi entreprenuership yang sifatnya berpengaruh positif berdasarkan indek persentase “setuju” dengan 3,0 % dan sangat setuju dengan 4,4 %, (c Adanya persepsi teacherprenuership yang sifatnya berpengaruh positif berdasarkan indek persentase “setuju” dengan 17,1 % dan sangat setuju dengan 16,2 %. Dari hasil penelitian ini bisa

  14. Tim Berners-Lee, World Wide Web inventor

    CERN Multimedia

    1998-01-01

    The "Internet, Web, What's next?" conference on 26 June 1998 at CERN: Tim Berners-Lee, inventor of the World Wide Web and Director of the W3C, explains how the Web came to be and gave his views on the future.

  15. Tim Berners-Lee: inventor de la World Wide Web

    OpenAIRE

    Universidad de Granada. Biblioteca

    2015-01-01

    El presente Cat??logo contiene la exposici??n organizada por la Biblioteca de la ETSIIT de la Universidad de Granada durante los meses de noviembre-diciembre de 2015 y titulada: "Tim Berners-Lee: inventor de la World Wide Web"

  16. Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.

    Science.gov (United States)

    Chacinska, Agnieszka; van der Laan, Martin; Mehnert, Carola S; Guiard, Bernard; Mick, David U; Hutu, Dana P; Truscott, Kaye N; Wiedemann, Nils; Meisinger, Chris; Pfanner, Nikolaus; Rehling, Peter

    2010-01-01

    Mitochondrial import of cleavable preproteins occurs at translocation contact sites, where the translocase of the outer membrane (TOM) associates with the presequence translocase of the inner membrane (TIM23) in a supercomplex. Different views exist on the mechanism of how TIM23 mediates preprotein sorting to either the matrix or inner membrane. On the one hand, two TIM23 forms were proposed, a matrix transport form containing the presequence translocase-associated motor (PAM; TIM23-PAM) and a sorting form containing Tim21 (TIM23(SORT)). On the other hand, it was reported that TIM23 and PAM are permanently associated in a single-entity translocase. We have accumulated distinct transport intermediates of preproteins to analyze the translocases in their active, preprotein-carrying state. We identified two different forms of active TOM-TIM23 supercomplexes, TOM-TIM23(SORT) and TOM-TIM23-PAM. These two supercomplexes do not represent separate pathways but are in dynamic exchange during preprotein translocation and sorting. Depending on the signals of the preproteins, switches between the different forms of supercomplex and TIM23 are required for the completion of preprotein import.

  17. Preliminary crystallographic studies of yeast mitochondrial peripheral membrane protein Tim44p

    Energy Technology Data Exchange (ETDEWEB)

    Josyula, Ratnakar [Department of Cell Biology, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States); Jin, Zhongmin [SER-CAT, APS, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); McCombs, Deborah; DeLucas, Lawrence [Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States); Sha, Bingdong, E-mail: bdsha@uab.edu [Department of Cell Biology, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States)

    2006-02-01

    Tim44p is an essential mitochondrial peripheral membrane protein. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, the yeast Tim44p has been crystallized. Protein translocations across mitochondrial membranes play critical roles in mitochondrion biogenesis. Protein transport from the cell cytosol to the mitochondrial matrix is carried out by the translocase of the outer membrane (TOM) complex and the translocase of the inner membrane (TIM) complexes. Tim44p is an essential mitochondrial peripheral membrane protein and a major component of the TIM23 translocon. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, the yeast Tim44p was crystallized. The crystals diffract to 3.2 Å using a synchrotron X-ray source and belong to space group P6{sub 3}22, with unit-cell parameters a = 124.25, c = 77.83 Å. There is one Tim44p molecule in one asymmetric unit, which corresponds to a solvent content of approximately 43%. Structure determination by MAD methods is under way.

  18. Architecture of the TIM23 inner mitochondrial translocon and interactions with the matrix import motor.

    Science.gov (United States)

    Ting, See-Yeun; Schilke, Brenda A; Hayashi, Masaya; Craig, Elizabeth A

    2014-10-10

    Translocation of proteins from the cytosol across the mitochondrial inner membrane is driven by action of the matrix-localized multi-subunit import motor, which is associated with the TIM23 translocon. The architecture of the import apparatus is not well understood. Here, we report results of site-specific in vivo photocross-linking along with genetic and coimmunoprecipitation analyses dissecting interactions between import motor subunits and the translocon. The translocon is composed of the two integral membrane proteins Tim23 and Tim17, each containing four membrane-spanning segments. We found that Tim23 having a photoactivatable cross-linker in the matrix exposed loop between transmembrane domains 1 and 2 (loop 1) cross-linked to Tim44. Alterations in this loop destabilized interaction of Tim44 with the translocon. Analogously, Tim17 having a photoactivatable cross-linker in the matrix exposed loop between transmembrane segments 1 and 2 (loop 1) cross-linked to Pam17. Alterations in this loop caused destabilization of the interaction of Pam17 with the translocon. Substitution of individual photoactivatable residues in Tim44 and Pam17 in regions we previously identified as important for translocon association resulted in cross-linking to Tim23 and Tim17, respectively. Our results are consistent with a model in which motor association is achieved via interaction of Tim23 with Tim44, which serves as a scaffold for association of other motor components, and of Tim17 with Pam17. As both Tim44 and Pam17 have been implicated as regulatory subunits of the motor, this positioning is conducive for responding to conformational changes in the translocon upon a translocating polypeptide entering the channel. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  19. Economist Innovation Award for Tim Berners-Lee

    CERN Multimedia

    2003-01-01

    In September, Tim Berners-Lee, who invented the World Wide Web at CERN and is now Director of the W3C World Wide Web Consortium, received the 2nd Economist Annual Innovation Award in Computing. With the award The Economist, a British weekly newspaper, recognises individuals responsible for breakthroughs in Bioscience, Computing, Energy and the Environment, and Telecommunications that have a profound impact on industry. A fifth award is given in a special "No Boundaries" category, observing innovation that transcends industries. Candidates for the awards are proposed by The Economist readers and writers, and by a group of judges. Tim Berners-Lee received the Computing award for his global hypertext project, to be known as the World Wide Web, which "forever altered the way information is shared" and is a huge contribution to the efficiency of the scientific community. Based on a programme for storing information using random associations called "Enquire", it...

  20. Dr TIM: Ray-tracer TIM, with additional specialist scientific capabilities

    Science.gov (United States)

    Oxburgh, Stephen; Tyc, Tomáš; Courtial, Johannes

    2014-03-01

    We describe several extensions to TIM, a raytracing program for ray-optics research. These include relativistic raytracing; simulation of the external appearance of Eaton lenses, Luneburg lenses and generalised focusing gradient-index lens (GGRIN) lenses, which are types of perfect imaging devices; raytracing through interfaces between spaces with different optical metrics; and refraction with generalised confocal lenslet arrays, which are particularly versatile METATOYs. Catalogue identifier: AEKY_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKY_v2_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licencing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 106905 No. of bytes in distributed program, including test data, etc.: 6327715 Distribution format: tar.gz Programming language: Java. Computer: Any computer capable of running the Java Virtual Machine (JVM) 1.6. Operating system: Any, developed under Mac OS X Version 10.6 and 10.8.3. RAM: Typically 130 MB (interactive version running under Mac OS X Version 10.8.3) Classification: 14, 18. Catalogue identifier of previous version: AEKY_v1_0 Journal reference of previous version: Comput. Phys. Comm. 183(2012)711 External routines: JAMA [1] (source code included) Does the new version supersede the previous version?: Yes Nature of problem: Visualisation of scenes that include scene objects that create wave-optically forbidden light-ray fields. Solution method: Ray tracing. Reasons for new version: Significant extension of the capabilities (see Summary of revisions), as demanded by our research. Summary of revisions: Added capabilities include the simulation of different types of camera moving at relativistic speeds relative to the scene; visualisation of the external appearance of generalised focusing gradient-index (GGRIN) lenses, including Maxwell fisheye, Eaton and Luneburg lenses; calculation of

  1. Hubungan Aktivitas Fisik Harian dengan Gangguan Menstruasi pada Mahasiswa Fakultas Kedokteran Universitas Andalas

    Directory of Open Access Journals (Sweden)

    Putri Anindita

    2016-09-01

    Full Text Available  AbstrakGangguan menstruasi dapat menimbulkan stres dan menurunkan kualitas hidup wanita. Gambaran menstruasi seseorang dapat memperlihatkan keadaan fungsi reproduksi seseorang dan risiko mengalami berbagai penyakit. Aktivitas fisik diperkirakan sebagai salah satu cara untuk mengurangi terjadinya gangguan menstruasi tersebut. Tujuan penelitian ini adalah menentukan hubungan antara aktivitas fisik harian dan gangguan menstruasi. Desain penelitian  menggunakan cross sectional study dengan jumlah subjek 90 mahasiswi Fakultas Kedokteran Universitas Andalas Angkatan 2011-2013. Data didapatkan dari kuisioner yang diisi langsung oleh masing-masing responden yang kemudian dianalisis denga uji chi-square. Hasil penelitian mendapatkan gangguan menstruasi terjadi pada 73,3% mahasiswi dengan gangguan yang paling sering terjadi yaitu dysmenorrhea sebanyak 63,3%. Sebagian besar mahasiswi tersebut memiliki aktivitas fisik harian yang cukup menurut rekomendasi WHO yaitu sebanyak 60%. Berdasarkan uji chi-square, tidak ditemukan adanya hubungan antara aktivitas fisik harian dan gangguan menstruasi (p= 0,846. Kesimpulan ialah tidak terdapat hubungan yang bermakna antara aktivitas fisik harian dan gangguan menstruasi pada mahasiswi Fakultas Kedokteran Universitas Andalas.Kata kunci: aktivitas fisik, gangguan menstruasi, mahasiswi FK AbstractMenstrual disorder is often cause stress and decrease the life quality of a woman. Menstrual pattern can describe the condition of reproduction function and risk of having several disease. Physical Activity is considered as one of the way to reduce menstrual disorder. The objective of this study was to determine the association between daily physical activity and menstrual disorder.This  study  used cross sectional design on 90 female medical student of Andalas University Class of 2011-2013 as the sample. The data from self reported questionnaire that was given to the students is analyzed using chi-square.The results show

  2. Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry

    Science.gov (United States)

    Moller-Tank, Sven; Kondratowicz, Andrew S.; Davey, Robert A.; Rennert, Paul D.

    2013-01-01

    The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction with PtdSer on the viral envelope. PtdSer liposomes but not phosphatidylcholine liposomes competed with TIM-1 for EBOV pseudovirion binding and transduction. Further, annexin V (AnxV) substituted for the TIM-1 IgV domain, supporting a PtdSer-dependent mechanism. Our findings suggest that TIM-1-dependent uptake of EBOV occurs by apoptotic mimicry. Additionally, TIM-1 enhanced infection of a wide range of enveloped viruses, including alphaviruses and a baculovirus. As further evidence of the critical role of enveloped-virion-associated PtdSer in TIM-1-mediated uptake, TIM-1 enhanced internalization of pseudovirions and virus-like proteins (VLPs) lacking a glycoprotein, providing evidence that TIM-1 and PtdSer-binding receptors can mediate virus uptake independent of a glycoprotein. These results provide evidence for a broad role of TIM-1 as a PtdSer-binding receptor that mediates enveloped-virus uptake. Utilization of PtdSer-binding receptors may explain the wide tropism of many of these viruses and provide new avenues for controlling their virulence. PMID:23698310

  3. TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.

    Directory of Open Access Journals (Sweden)

    Stephanie Jemielity

    2013-03-01

    Full Text Available Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4 specifically bind phosphatidylserine (PS. TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengue virus. Here we show that TIM1 promotes infection of retroviruses and virus-like particles (VLPs pseudotyped with a range of viral entry proteins, in particular those from the filovirus, flavivirus, New World arenavirus and alphavirus families. TIM1 also robustly enhanced the infection of replication-competent viruses from the same families, including dengue, Tacaribe, Sindbis and Ross River viruses. All interactions between TIM1 and pseudoviruses or VLPs were PS-mediated, as demonstrated with liposome blocking and TIM1 mutagenesis experiments. In addition, other PS-binding proteins, such as Axl and TIM4, promoted infection similarly to TIM1. Finally, the blocking of PS receptors on macrophages inhibited the entry of Ebola VLPs, suggesting that PS receptors can contribute to infection in physiologically relevant cells. Notably, infection mediated by the entry proteins of Lassa fever virus, influenza A virus and SARS coronavirus was largely unaffected by TIM1 expression. Taken together our data show that TIM1 and related PS-binding proteins promote infection of diverse families of enveloped viruses, and may therefore be useful targets for broad-spectrum antiviral therapies.

  4. Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria.

    Science.gov (United States)

    Mokranjac, Dejana; Sichting, Martin; Popov-Celeketić, Dusan; Mapa, Koyeli; Gevorkyan-Airapetov, Lada; Zohary, Keren; Hell, Kai; Azem, Abdussalam; Neupert, Walter

    2009-03-01

    Transport of essentially all matrix and a number of inner membrane proteins is governed, entirely or in part, by N-terminal presequences and requires a coordinated action of the translocases of outer and inner mitochondrial membranes (TOM and TIM23 complexes). Here, we have analyzed Tim50, a subunit of the TIM23 complex that is implicated in transfer of precursors from TOM to TIM23. Tim50 is recruited to the TIM23 complex via Tim23 in an interaction that is essentially independent of the rest of the translocase. We find Tim50 in close proximity to the intermembrane space side of the TOM complex where it recognizes both types of TIM23 substrates, those that are to be transported into the matrix and those destined to the inner membrane, suggesting that Tim50 recognizes presequences. This function of Tim50 depends on its association with TIM23. We conclude that the efficient transfer of precursors between TOM and TIM23 complexes requires the concerted action of Tim50 with Tim23.

  5. Pembuatan Virtual Kampus Sistem Komputer Fakultas Teknik Universitas Diponegoro Menggunakan Jaringan Lokal Berbasis VRML

    Directory of Open Access Journals (Sweden)

    Hendra Taufiq Oktafianto

    2015-01-01

    Full Text Available Dalam bidang informasi banyak cara dalam menginformasikan data, baik secara tertulis, gambar, suara, gambar dan suara. Saat ini banyak dikembangkan teknologi dengan menggunakan metode visual yang interaktif, seperti dunia virtual yang membuat seolah-olah informasi tersebut di dapat sesuai dengan pengalaman memasuki daerah yang di lihat pada dunia virtual tersebut. Metode tersebut adalah pengembangan teknologi virtual reality yang dibuat dengan menggunakan 3DS Max sebagai software untuk menghasilkan gambar yang menarik. Pengaplikasian yang dikembangkan dengan media web dimana setiap pengguna lebih mudah dalam dalam menggunakan aplikasi tersebut. Metode pengambangan yang dirancang adalah memadukan teknologi virtual reality dengan web. Dimana aplikasi tersebut terdapat didalam tampilan web yang didukun basis data untuk mempermudah aktor admin dalam mengolah data. Pada browser yang digunakan akan di pasang plug-in cortona3d agar dapat menampilkan file ekstensi tiga dimensi yang dapat di tampilkan browser. Hasil dari pembuatan aplikasi ini adalah terancangnya sebuah aplikasi yang menggunakan teknologi virtual reality modeling language dengan studi kasus Kampus Sistem Komputer Fakultas Teknik Universitas Diponegoro menggunakan jaringan lokal berbasis VRML

  6. GANGGUAN CEMAS PADA MAHASISWA SEMESTER I DAN VII PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA

    Directory of Open Access Journals (Sweden)

    Dyah Chandratika

    2015-05-01

    Full Text Available Penting untuk dilakukan penelitian mengenai gangguan cemas pada mahasiswa kedokteran karena tingginya tingkat stres mahasiswa terutama pada tahun pertama perkuliahan. Tujuan penelitian ini adalah untuk mengetahui prevalensi dan perbedaan skor  gangguan  cemas  pada mahasiswa  semester  I dan  VII serta untuk  mengetahui perbedaan skor gangguan cemas antara mahasiswa laki-laki dan perempuan di Fakultas Kedokteran Universitas Udayana. Desain penelitian ini adalah cross sectional analitik. Pengambilan sampel dilakukan secara random sampling. Sampel mengisi identitas, kuesioner L-MMPI, kuesioner Hamilton Anxiety Rating Scale (HARS. Kemudian dihitung prevalensi gangguan cemas tiap kelompok serta data dianalisis menggunakan uji t-independen. Terdapat 15 orang (25,0% mahasiswa semester I dan 7 orang (11,7% mahasiswa semester VII yang mengalami gangguan cemas. Dari hasil uji t-independen antara skor gangguan cemas mahasiswa semester I dan VII diperoleh nilai p = 0,001 (<0,05. Sedangkan diperoleh p = 0,080 antara mahasiswa laki-laki dan perempuan pada semester I dan p = 0,744 antara mahasiswa laki-laki dan perempuan pada semester VII. Prevalensi gangguan cemas pada mahasiswa semester I yaitu 25,0% sedangkan 11,7% pada mahasiswa semester VII. Terdapat perbedaan bermakna antara skor gangguan cemas mahasiswa semester I dan VII. Tidak ditemukan perbedaan bermakna skor gangguan cemas antara laki-laki dan perempuan.   

  7. Perancangan dan Implementasi Sistem Informasi Perpustakaan di Program Studi Teknik Lingkungan Fakultas Teknik Undip

    Directory of Open Access Journals (Sweden)

    Lia Dorothy

    2014-11-01

    Full Text Available Perkembangan teknologi informasi menciptakan keunggulan kompetitif dalam berbagai bidang. Perkembangan ini didukung oleh industri perangkat keras dan perangkat lunak komputer yang terus berkembang, yakni dengan pengaksesan dan pemrosesan informasi yang cepat, akurat, dan efisien melalui sebuah sistem informasi. Pengelolaan data buku di perpustakaan Teknik Lingkungan masih dilakukan menggunakan microsoft office excel, sedangkan pengelolaan data anggota dan data peminjaman masih dicatat secara manual. Oleh karena itu, diperlukan sebuah penelitian untuk membangun sebuah sistem informasi perpustakaan yang dapat mempermudah pengelolaan data dan aktivitas perpustakaan di Program Studi Teknik Lingkungan. Sistem informasi perpustakaan terkomputerisasi ini diharapkan dapat membantu pengelolaan data buku dan data anggota, transaksi peminjaman dan pengembalian buku, serta menghasilkan laporan untuk keperluan administrasi perpustakaan, sehingga dapat meningkatkan efektifitas kinerja karyawan. Sistem informasi perpustakaan ini berbasis web, dikembangkan dengan bahasa pemrograman PHP dan basis data MySQL, serta menggunakan framework CodeIgniter. Sistem informasi ini juga dilengkapi dengan barcode reader yang digunakan untuk mempermudah pengelolaan data buku. Penelitian dikembangkan dengan metode SDLC (System Development Life Cycle. Langkah-langkah penelitian meliputi tahap perencanaan, tahap analisis, tahap perancangaan, tahap implementasi, tahap pengujian, dan tahap pemeliharaan. Sistem dirancang dengan menggunakan diagram UML (Unified Modelling Language dan diuji dengan pengujian kotak hitam (blackbox testing. Semua menu dalam sistem informasi perpustakaan dan barcode reader dapat bekerja dengan baik. Sistem informasi perpustakaan telah diimplementasikan di Program Studi Teknik Lingkungan Fakultas Teknik UNDIP. Sistem informasi ini menambah kualitas pelayanan pada perpustakaan Teknik Lingkungan.

  8. REMASTERING LIVE USB UNTUK LAMP PADA FAKULTAS SAINS DAN TEKNOLOGI PALEMBANG

    Directory of Open Access Journals (Sweden)

    Klaudius Jevanda B.S.

    2015-11-01

    Full Text Available ABSTRAK Penelitian ini bertujuan untuk membuat distribusi Linux bernama Lubuntu yang memfokuskan diri pada desktop yang ringan serta ditujukan untuk menjadi lingkungan web server yang free dalam bentuk live USB. Dimana, penelitian ini menjelaskan tentang desain dan implementasi dari distribusi Linux Lubuntu itu sendiri yang nantinya bisa terus diperbaiki, disempurnakan dan dimungkinkan untuk dimodifikasi serta dipelajari oleh pihak lain. Lubuntu dikembangkan dengan memodifikasi dari Linux Lubuntu 14.04 dari tahap penambahan program, penghapusan program dan konfigurasi sampai pada tahap pembuatan Live USB untuk LAMP (Linux Apache Mysql PHP menggunakan metode remastering. Hasil dari penelitian ini berupa Live USB yang berisi tool untuk lingkungan web server. Tool utama dalam Live USB diantaranya adalah phpmyadmin, gimp, inkscape, dan bluefish. Keluaran penelitian ini, diharapkan bisa digunakan sebagai sistem operasi dan dikhususkan dalam lingkungan web server yang nyaman untuk dipergunakan dalam proses belajar mengajar pada matakuliah sistem operasi, pemrograman basis web I, dan pemrograman basis web II di Fakultas Sains dan Teknologi Universitas Katolik Musi Charitas palembang. Kata kunci: linux, web server, LAMP, remastering, live usb.

  9. Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy

    DEFF Research Database (Denmark)

    Meggyes, Matyas; Miko, Eva; Polgar, Beata

    2014-01-01

    PROBLEM: The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/TIM-3 pathway as an important...... negative regulator of Th1 immunity and tolerance induction. Data about the TIM-3/Gal-9 pathway in the pathogenesis of human diseases is emerging, but their possible role during human pregnancy is not precisely known. The aim of our study was to investigate the number, phenotype and functional activity...... of TIM-3+ peripheral blood mononuclear cells during healthy human pregnancy. METHODS OF STUDY: 57 healthy pregnant women [first trimester (n = 16); second trimester (n = 19); third trimester (n = 22)] and 30 non-pregnant controls were enrolled in the study. We measured the surface expression of TIM-3...

  10. HUBUNGAN ANTARA TIPE KEPRIBADIAN INTROVERT DAN EKSTROVERT DENGAN KEJADIAN STRES PADA KO-ASISTEN ANGKATAN TAHUN 2011 FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA

    Directory of Open Access Journals (Sweden)

    I Gede Suprayoga Sukmana Putra

    2015-07-01

    Full Text Available Stres merupakan salah satu masalah psikologis yang seringkali dijumpai di kalangan koasisten Fakultas Kedokteran. Sumber stres dapat bersifat internal maupun eksternal. Tipe kepribadian merupakan salah satu faktor yang memengaruhi munculnya stres. Tujuan dari penelitian ini adalah untuk mencari hubungan antara tipe kepribadian introvert dan ekstrovert dengan kejadian stres pada koasisten angkatan tahun 2011 Fakultas Kedokteran Universitas Udayana. Desain penelitian yang digunakan adalah cross sectional analitik. Pengambilan data dilakukan dengan menggunakan kuesioner yang disebar pada 62 koasisten angkatan tahun 2011 Fakultas Kedokteran Universitas Udayana. Analisis bivariat dilakukan dengan uji chi square menggunakan perangkat lunak SPSS 16.0. Jumlah responden yang memiliki kepribadian ekstrovert lebih banyak dibandingkan dengan yang introvert (56,5% vs 43,5% dan responden yang mengalami stres berjumlah 33 orang (53,2%. Analisis bivariat menunjukkan adanya hubungan yang signifikan antara tipe kepribadian introvert dan ekstrovert dengan kejadian stres (p = 0,000 (p < 0,05. Dari hasil penelitian disimpulkan bahwa terdapat hubungan antara tipe kepribadian introvert dan ekstrovert dengan kejadian stres pada koasisten angkatan tahun 2011 Fakultas Kedokteran Universitas Udayana.    

  11. Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria.

    Science.gov (United States)

    Waegemann, Karin; Popov-Čeleketić, Dušan; Neupert, Walter; Azem, Abdussalam; Mokranjac, Dejana

    2015-03-13

    Translocation of the majority of mitochondrial proteins from the cytosol into mitochondria requires the cooperation of TOM and TIM23 complexes in the outer and inner mitochondrial membranes. The molecular mechanisms underlying this cooperation remain largely unknown. Here, we present biochemical and genetic evidence that at least two contacts from the side of the TIM23 complex play an important role in TOM-TIM23 cooperation in vivo. Tim50, likely through its very C-terminal segment, interacts with Tom22. This interaction is stimulated by translocating proteins and is independent of any other TOM-TIM23 contact known so far. Furthermore, the exposure of Tim23 on the mitochondrial surface depends not only on its interaction with Tim50 but also on the dynamics of the TOM complex. Destabilization of the individual contacts reduces the efficiency of import of proteins into mitochondria and destabilization of both contacts simultaneously is not tolerated by yeast cells. We conclude that an intricate and coordinated network of protein-protein interactions involving primarily Tim50 and also Tim23 is required for efficient translocation of proteins across both mitochondrial membranes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Infrared spectroscopy for geologic interpretation of TIMS data

    Science.gov (United States)

    Bartholomew, Mary Jane

    1986-01-01

    The Portable Field Emission Spectrometer (PFES) was designed to collect meaningful spectra in the field under climatic, thermal, and sky conditions that approximate those at the time of the overflight. The specifications and procedures of PFES are discussed. Laboratory reflectance measurements of rocks and minerals were examined for the purpose of interpreting Thermal Infrared Multispectral Scanner (TIMS) data. The capability is currently being developed to perform direct laboratory measurement of the normal spectral radiance of Earth surface materials at low temperatures (20 to 30 C) at the Jet Propulsion Laboratory.

  13. Tim-3 Up-regulation in Patients with Gastric Cancer and Peptic Ulcer Disease

    Science.gov (United States)

    Naghavi-Alhosseini, Mahdieh; Tehrani, Mohsen; Ajami, Abolghasem; Rafiei, Alireza; Taghvaei, Tarang; Vahedi-Larijani, Laleh; Hossein-Nataj, Hadi; Asgarian-Omran, Hossein

    2017-01-01

    Background: T-cell immunoglobulin and mucin domain protein-3 (Tim-3), an inhibitory immunoregulatory receptor, has been recently implicated in tumor biology and tumor-associated immune suppression. In the present study, expression of Tim-3 was evaluated in gastric cancer (GC) and peptic ulcer disease (PUD) at both mRNA and protein levels. Methods: A total of 133 gastric tissue biopsies, comprising 43 from GC cases, 48 from PUD and 42 from non-ulcer dyspepsia (NUD) serving as controls were collected. Additionally, non-neoplastic adjacent tissue biopsies were also obtained from 6 patients with GC. Infection with Helicobacter pylori was determined by the rapid urease test for all participants and H&E staining was conducted for GC and PUD patients. Tim-3 relative mRNA expression was determined by SYBR Green based Real-Time PCR using β-actin as a reference gene. Tim-3 protein expression was also studied by immunohistochemistry in 7 GC, 7 PUD and 10 NUD tissue samples. Results: Tim-3 was expressed at higher levels in GC (p=0.030) and PUD (p=0.022) cases compared to he NUD group. Among paired samples obtained from gastric cancer patients, tumor tissues showed elevated Tim-3 expression (p=0.019) in comparison with adjacent non-neoplastic biopsies. Tim-3 mRNA findings were supported by detection of more Tim-3 protein in cancerous (p=0.002) and ulcerative (p=0.01) tissues than in controls. Tim-3 was similarly expressed in H. pylori positive and negative cases. Conclusion: Higher Tim-3 expression in patients with gastric cancer and peptic ulcer implies that it might be involved in immune regulation and establishment of these gastrointestinal diseases. Targeted immunotherapy by blocking of inhibitory receptors like Tim-3 could be a promising approach for gastric cancer treatment. PMID:28441784

  14. Cultura digital jovem: as TIMS invadem as periferias, e agora?

    Directory of Open Access Journals (Sweden)

    Márcia Gonçalves Nogueira

    2014-08-01

    Full Text Available Objective of this work is to present a literature review on Young and the Digital Cultural transformations caused by the dissemination of Information Technology and Communication Mobile and wireless (TIMS on the outskirts of the metropolitan area of Recife. To this end, we seek to identify how young periphery, high school students of a public school, they experience the Digital Culture in different social spaces; among them the school, scene of many tensions and generational conflicts and language as social and cultural use of these mobile devices. We highlight some theoretical approaches to the phenomenon of mobile communication and the concept of Digital Culture, adopted in this work. Proposing a reflection on the role of school in the current social context of constant cultural and linguistic transformations multimodality of the digital age. Finally, we present an exercise of looking on Youth Cultures, from different theoretical, to better understand the multiple transits covered by surveyed youth to express themselves and make sense of their audiovisual productions, mediated by TIMS. This theoretical argument was used in the dissertation in mathematics education and technology by one of the authors of this article. Therefore, we hope to contribute to further research on Digital Youth Culture in the context of the periphery.

  15. “This is you”: Encountering Shakespeare with Tim Crouch

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    Sara Soncini

    2017-11-01

    Full Text Available This essay considers Tim Crouch's "I Shakespeare", a suite of monologue plays based on "The Tempest" ("I, Caliban", 2003, "A Midsummer Night's Dream" ("I, Peaseblossom", 2004, "Macbeth" ("I, Banquo", 2005, "Twelfth Night" ("I, Malvolio", 2010 and "Julius Caesar" ("I, Cinna (the poet", 2012. While originally designed for a young audience, Crouch's adaptations have been performed in a variety of theatrical contexts that have added new and probably unforeseen dimensions to their negotiations with Shakespeare. In my analysis I turn to the notion of mobility as a key analytical tool to elucidate the method, aims, as well as the broader cultural meaning of Tim Crouch's reworkings. In his hands, Shakespeare is mobilized as a powerful resource to activate spectators and emphasize their co-authorship in the process of theatre. Through a combination of textual strategies and performance methods, the monologues construct the identities of Shakespeare's characters as multiple and mutable and, in parallel, cast their addressees in fluid, often contradictory roles. My main line of argument is that the plays' propensity of motion is rooted in their emphasis on Shakespeare as a highly mobile cultural signifier which seems confirmed by the monologues' journeys outside the UK. The further adaptational practices triggered by these encounters with foreign audiences are testament to the flexibility of Crouch's dramaturgy of process and its aptitude to accommodate new discursive identities and adjust to each new context of reception.

  16. U-series dating using thermal ionisation mass spectrometry (TIMS)

    International Nuclear Information System (INIS)

    McCulloch, M.T.

    1999-01-01

    U-series dating is based on the decay of the two long-lived isotopes 238 U(τ 1/2 =4.47 x 10 9 years) and 235 U (τ 1/2 0.7 x 10 9 years). 238 U and its intermediate daughter isotopes 234 U (τ 1/2 = 245.4 ka) and 230 Th (τ 1/2 = 75.4 ka) have been the main focus of recently developed mass spectrometric techniques (Edwards et al., 1987) while the other less frequently used decay chain is based on the decay 235 U to 231 Pa (τ 1/2 = 32.8 ka). Both the 238 U and 235 U decay chains terminate at the stable isotopes 206 Pb and 207 Pb respectively. Thermal ionization mass spectrometry (TIMS) has a number of inherent advantages, mainly the ability to measure isotopic ratios at high precision on relatively small samples. In spite of these now obvious advantages, it is only since the mid-1980's when Chen et al., (1986) made the first precise measurements of 234 U and 232 Th in seawater followed by Edwards et al., (1987) who made combined 234 U- 230 Th measurements, was the full potential of mass spectrometric methods first realised. Several examples are given to illustrate various aspects of TIMS U-series

  17. Space Solar Power Technical Interchange Meeting 2: SSP TIM 2

    Science.gov (United States)

    Sanders, Jim; Hawk, Clark W.

    1998-01-01

    The 2nd Space Solar Power Technical Interchange Meeting (SSP TIM 2) was conducted September 21st through 24th with the first part consisting of a Plenary session. The summary results of this Plenary session are contained in part one of this report. The attendees were then organized into Working Breakout Sessions and Integrated Product Team (IPT) Sessions for the purpose of conducting in-depth discussions in specific topic areas and developing a consensus as to appropriate study plans and actions to be taken. The Second part covers the Plenary Summary Session, which contains the summary results of the Working Breakout Sessions and IPT Sessions. The appendix contains the list of attendees. The ob'jective was to provide an update for the study teams and develop plans for subsequent study activities. This SSP TIM 2 was initiated and the results reported electronically over the Internet. The International Space Station (ISS) could provide the following opportunities for conducting research and technology (R&T) which are applicable to SSP: (1) Automation and Robotics, (2) Advanced Power Generation, (3) Advanced Power Management & Distribution (PMAD), (4) Communications Systems and Networks, (5) Energy Storage, (6) In Space Propulsion (ISP), (7) Structural Dynamics and Control, and Assembly and (8) Wireless Power Transmission.

  18. MOTIVASI DAN PILIHAN KARIR MAHASISWA TINGKAT AKHIR FAKULTAS KEDOKTERAN UNIVERSITAS AIRLANGGA, SURABAYA

    Directory of Open Access Journals (Sweden)

    Pramita Andarwati

    2017-01-01

    karir mahasiswa dan motivasi yang mendasarinya. Metode: Jenis penelitian observasional yang dilakukan pada Maret hingga September 2014. Sampel adalah seluruh mahasiswa tingkat akhir Fakultas Kedokteran Universitas Airlangga periode 2009. Pengumpulan data dilakukan dengan kuesioner dandiskusi kelompok terarah Responden ditanyakan tentang pilihan karier dan motivasinya. Analisis data menggunakan uji chi square dan thematic-content analysis. Hasil: Didapat response rate responden sebesar 95,2% (n = 180. Sebagian besar, 62,2% responden memilih karir sebagai klinisi di mana peminatan terbanyak (20,4%adalah spesialis ilmu penyakit dalam. Sementara itu, latar belakang sosial mahasiswa (daerah asal, pendidikan akhir dan profesi orang tua, sumber dana untuk kuliah, kemampuan akademis (Indeks Prestasi Kumulatif dan pengalaman selama masa pendidikan tidak berhubungan dengan pilihan karir (klinisi dan non klinisi. Diungkapkan bahwa keseimbangan karier dan kehidupan keluarga, minat pada bidang tertentu serta besaran penghasilan mendasari pemilihan spesialis. Kesimpulan: Motivasi utama yang mendasari pilihan karir adalah keseimbangan kehidupan pekerjaan dan keluarga, minat pada bidang tertentu serta besaran penghasilan. Saran: Institusi pendidikan, Fakultas Kedokteran Universitas Airlangga diharapkan dapat memberikan motivasi kepada peserta didiknya melalui metode pengajaran yang menarik dan menciptakan lingkungan akademis agar mendukung tumbuhnya minat mempelajari ilmu kedokteran nonklinis dan klinis secara berimbang.  

  19. Gambaran Perubahan Tekanan Darah Pasca Olahraga Futsal pada Mahasiswa Fakultas Kedokteran Universitas Andalas

    Directory of Open Access Journals (Sweden)

    Akdri Andi

    2016-08-01

    Full Text Available AbstrakPada olahraga tertentu seperti futsal,  tekanan darah dapat naik menjadi 150-200 mmHg. Sebuah penelitian menyatakan  60 kematian mendadak pasca olahraga, 58 diantaranya disebabkan oleh kelainan kardiovaskuler. Tujuan penelitian ini adalah untuk mengetahui gambaran perubahan tekanan darah pasca olahraga futsal pada mahasiswa Fakultas Kedokteran Universitas Andalas. Rancangan penelitian yang digunakan adalah deskriptif observasional dengan menggunakan desain cross-sectional study. Subjek yang digunakan adalah 30 orang mahasiswa Fakultas Kedokteran Universitas Andalas yang memenuhi kriteria inklusi dan eklusi pada April 2014. Olahraga futsal dilakukan 30 menit lalu dilakukan pengukuran tekanan darah sesaat, 15, 30 dan 60 menit dengan menggunakan sphygmomanometer air raksa dan stetoskop. Hasil penelitian didapatkan peningkatan tekanan darah sistolik sesaat setelah olahraga futsal pada semua sampel dengan peningkatan sebesar 20 mmHg pada 18 orang (60% dan 25 orang (83,8% tidak mengalami perubahan tekanan darah diastolik. Pada 15 menit setelah olahraga futsal, 18 orang (60% terjadi penurunan tekanan darah sistolik sebesar 20 mmHg dan 26 orang (86,67% tidak mengalami perubahan tekanan darah diastolik. Pada 30 menit setelah olahraga, 4 orang (13,3% mengalami penurunan tekanan darah sistolik. Satu jam setelah olahraga, semua subjek telah mencapai tekanan darah awal.Kata kuncl: tekanan darah, olahraga futsal sesaat, 15 menit, 30 menit, satu jam AbstractIn certain exercise such as futsal, blood pressure can raise around 150-200 mmHg. A study has identified 60 sudden deaths after sports and 58 were caused by cardiovascular disorders. The objective of this study was to describe changes in blood pressure after futsal exercise in students of Medical Faculty of Andalas University. The design is descriptive observational using a cross-sectional study. The 30 subjects were taken base on inclusion and exclusion criteria. This study was conducted on April

  20. BENTUK KECURANGAN AKADEMIK (ACADEMIC CHEATING MAHASISWA PGMI FAKULTAS TARBIYAH DAN KEGURUAN UIN ALAUDDIN MAKASSAR

    Directory of Open Access Journals (Sweden)

    Nursalam Nursalam

    2013-12-01

    Full Text Available Abstrak: Penelitian ini bertujuan untuk mengetahui bentuk-bentuk kecurangan akademik (academic cheating mahasiswa PGMI Fakultas Tarbiyah dan Keguruan UIN Alauddin Makassar. Hasil penelitian menunjukkan bahwa bentuk-bentuk kecu-rangan akademik yang dilakukan oleh mahasiswa PGMI adalah menyontek pe-kerjaan teman pada saat ujian, membuka buku saat ujian, menyalin tugas teman, membuka internet melalui handphone, copy paste dari internet. Faktor-faktor yang menyebabkan mahasiswa melakukan kecurangan akademik adalah sangat sulit mengerjakan tugas yang diberikan oleh dosen membutuhkan jawaban yang real, mahasiswa terpengaruh dengan adanya mahasiswa lain yang menyontek, soal yang diberikan oleh dosen terlalu sulit, waktu yang disediakan sangat singkat, mahasiswa tidak memahami materi yang diujikan, ragu dengan jawaban sendiri, tidak ada hukuman yang diberikan jika berbuat curang, mendapatkan nilai yang bagus. Abstract: This study aims to determine the forms of academic cheatings of the students of Madrasah Ibtidaiyah Teacher Education Program at Tarbiyah and Teacher Training Faculty of UIN Alauddin Makassar. The results showed that the forms of academic cheating committed by the students while doing the exam are copying their friends’ work, opening book, copying friend’ task, open the internet via mobile phones, and doing copy-paste from the internet. The factors that lead to student academic cheating is the task given by the lecturers is very difficult and it needs text-book answers, the students affected by the presence of other students who cheat, questions given by the lecturers were too difficult, the time provided in the exam is very short, the students do not understand the material tested, they are unsure with their own answers, no penalty is given for cheating, and even the cheaters get good grades.

  1. Sild humanitaar- ja loodusteaduste vahel : intervjuu Aberdeeni ülikooli sotsiaalantropoloogia professori Tim Ingoldiga / Tim Ingold ; interv. Alo Joosepson, Kaie Kotov, Silver Rattasepp, Riste Keskpaik

    Index Scriptorium Estoniae

    Ingold, Tim

    2004-01-01

    4. rahvusvahelise keskkonnaesteetika ja -semiootika konverentsi "Kultuur, loodus, semiootika: kohad" üks peaesineja Tim Ingold tegeleb 1990-ndatest alates antropoloogia ja kunsti suhte uurimisega ning loeb kursust "Antropoloogia, arheoloogia, kunst ja arhitektuur"

  2. Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

    LENUS (Irish Health Repository)

    Vega-Carrascal, Isabel

    2012-02-01

    The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. It has been reported that proinflammatory cytokine dysregulation and neutrophil-dominated inflammation are the main causes of morbidity in cystic fibrosis (CF). However, the role of TIM receptors in CF has not been investigated. In this study, we demonstrated that TIM-3 is constitutively overexpressed in the human CF airway, suggesting a link between CF transmembrane conductance regulator (CFTR) function and TIM-3 expression. Blockade of CFTR function with the CFTR inhibitor-172 induced an upregulation of TIM-3 and its ligand galectin-9 in normal bronchial epithelial cells. We also established that TIM-3 serves as a functional receptor in bronchial epithelial cells, and physiologically relevant concentrations of galectin-9 induced TIM-3 phosphorylation, resulting in increased IL-8 production. In addition, we have demonstrated that both TIM-3 and galectin-9 undergo rapid proteolytic degradation in the CF lung, primarily because of neutrophil elastase and proteinase-3 activity. Our results suggest a novel intrinsic defect that may contribute to the neutrophil-dominated immune response in the CF airways.

  3. Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

    LENUS (Irish Health Repository)

    Vega-Carrascal, Isabel

    2011-03-01

    The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. It has been reported that proinflammatory cytokine dysregulation and neutrophil-dominated inflammation are the main causes of morbidity in cystic fibrosis (CF). However, the role of TIM receptors in CF has not been investigated. In this study, we demonstrated that TIM-3 is constitutively overexpressed in the human CF airway, suggesting a link between CF transmembrane conductance regulator (CFTR) function and TIM-3 expression. Blockade of CFTR function with the CFTR inhibitor-172 induced an upregulation of TIM-3 and its ligand galectin-9 in normal bronchial epithelial cells. We also established that TIM-3 serves as a functional receptor in bronchial epithelial cells, and physiologically relevant concentrations of galectin-9 induced TIM-3 phosphorylation, resulting in increased IL-8 production. In addition, we have demonstrated that both TIM-3 and galectin-9 undergo rapid proteolytic degradation in the CF lung, primarily because of neutrophil elastase and proteinase-3 activity. Our results suggest a novel intrinsic defect that may contribute to the neutrophil-dominated immune response in the CF airways.

  4. Tim Berners-Lee at the RSIS conference from 8-9 December 2003.

    CERN Multimedia

    Patrice Loiez

    2003-01-01

    Tim Berners-Lee participated in the Role of Science in the Information Society conference held at CERN from 8-9 December 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  5. U-series dating using thermal ionisation mass spectrometry (TIMS)

    Energy Technology Data Exchange (ETDEWEB)

    McCulloch, M.T. [Australian National University, Canberra, ACT (Australia). Research School of Earth Science

    1999-11-01

    U-series dating is based on the decay of the two long-lived isotopes{sup 238}U({tau}{sub 1/2}=4.47 x 10{sup 9} years) and {sup 235}U ({tau}{sub 1/2} 0.7 x 10{sup 9} years). {sup 238}U and its intermediate daughter isotopes {sup 234}U ({tau}{sub 1/2} = 245.4 ka) and {sup 230}Th ({tau}{sub 1/2} = 75.4 ka) have been the main focus of recently developed mass spectrometric techniques (Edwards et al., 1987) while the other less frequently used decay chain is based on the decay {sup 235}U to {sup 231}Pa ({tau}{sub 1/2} = 32.8 ka). Both the {sup 238}U and {sup 235}U decay chains terminate at the stable isotopes {sup 206}Pb and {sup 207}Pb respectively. Thermal ionization mass spectrometry (TIMS) has a number of inherent advantages, mainly the ability to measure isotopic ratios at high precision on relatively small samples. In spite of these now obvious advantages, it is only since the mid-1980`s when Chen et al., (1986) made the first precise measurements of {sup 234}U and {sup 232}Th in seawater followed by Edwards et al., (1987) who made combined {sup 234}U-{sup 230}Th measurements, was the full potential of mass spectrometric methods first realised. Several examples are given to illustrate various aspects of TIMS U-series 9 refs., 3 figs.

  6. Traditional Indian medicine (TIM and traditional Korean medicine (TKM: aconstitutional-based concept and comparison

    Directory of Open Access Journals (Sweden)

    Young Min Kang

    2017-06-01

    Full Text Available Traditional and complementary medicine (T&CM plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM and traditional Korean medicine (TKM basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization reports. Despite the fact that TIM and TKM have individual qualities that are unique from each other including different histories of origin, they share a lot in common. Apart from Homeopathy in TIM, both systems are hinged on similar principle of body constitutional-based concept and similar disease diagnosis methods of mainly auscultation, palpation, visual inspection, and interrogation. Similarly, the treatment methods of TIM and TKM follow similar patterns involving use of medicinal herbs, moxibustion, acupuncture, cupping, and manual therapy. Both T&CM are majorly practiced in well-established hospitals by T&CM doctors who have undergone an average of 6–7 years of specialized trainings. However, unlike TIM which has less insurance coverage, the popularity of TKM is majorly due to its wide national insurance coverage. These two medical traditions occupy increasingly greater portion of the global market. However, TIM especially Ayurveda has gained more global recognition than TKM although the emergence of Sasang Constitutional Medicine in TKM is beginning to become more popular. This comparative analysis between TIM and TKM may provide vital and insightful contribution towards constitutional-based concept for further development and future studies in T&CM.

  7. Traditional Indian medicine (TIM) and traditional Korean medicine (TKM): aconstitutional-based concept and comparison.

    Science.gov (United States)

    Kang, Young Min; Komakech, Richard; Karigar, Chandrakant Shivappa; Saqib, Asma

    2017-06-01

    Traditional and complementary medicine (T&CM) plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM) and traditional Korean medicine (TKM) basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization reports. Despite the fact that TIM and TKM have individual qualities that are unique from each other including different histories of origin, they share a lot in common. Apart from Homeopathy in TIM, both systems are hinged on similar principle of body constitutional-based concept and similar disease diagnosis methods of mainly auscultation, palpation, visual inspection, and interrogation. Similarly, the treatment methods of TIM and TKM follow similar patterns involving use of medicinal herbs, moxibustion, acupuncture, cupping, and manual therapy. Both T&CM are majorly practiced in well-established hospitals by T&CM doctors who have undergone an average of 6-7 years of specialized trainings. However, unlike TIM which has less insurance coverage, the popularity of TKM is majorly due to its wide national insurance coverage. These two medical traditions occupy increasingly greater portion of the global market. However, TIM especially Ayurveda has gained more global recognition than TKM although the emergence of Sasang Constitutional Medicine in TKM is beginning to become more popular. This comparative analysis between TIM and TKM may provide vital and insightful contribution towards constitutional-based concept for further development and future studies in T&CM.

  8. Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors.

    Science.gov (United States)

    Patel, Jaina; Bozeman, Erica N; Selvaraj, Periasamy

    2012-12-01

    Evaluation of: Chiba S, Baghdadi M, Akiba H et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat. Immunol. 13, 832-842 (2012). The identification of TIM-3 expression on tumor-associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells; however, its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid-mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 monoclonal antibody-treated mice or mice depleted of all DCs, which indicated that a significant role is played by TADCs in inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings.

  9. Airborne Thermal Infrared Multispectral Scanner (TIMS) images over disseminated gold deposits, Osgood Mountains, Humboldt County, Nevada

    Science.gov (United States)

    Krohn, M. Dennis

    1986-01-01

    The U.S. Geological Survey (USGS) acquired airborne Thermal Infrared Multispectral Scanner (TIMS) images over several disseminated gold deposits in northern Nevada in 1983. The aerial surveys were flown to determine whether TIMS data could depict jasperoids (siliceous replacement bodies) associated with the gold deposits. The TIMS data were collected over the Pinson and Getchell Mines in the Osgood Mountains, the Carlin, Maggie Creek, Bootstrap, and other mines in the Tuscarora Mountains, and the Jerritt Canyon Mine in the Independence Mountains. The TIMS data seem to be a useful supplement to conventional geochemical exploration for disseminated gold deposits in the western United States. Siliceous outcrops are readily separable in the TIMS image from other types of host rocks. Different forms of silicification are not readily separable, yet, due to limitations of spatial resolution and spectral dynamic range. Features associated with the disseminated gold deposits, such as the large intrusive bodies and fault structures, are also resolvable on TIMS data. Inclusion of high-resolution thermal inertia data would be a useful supplement to the TIMS data.

  10. The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism.

    Science.gov (United States)

    Goldman, Aaron David; Beatty, Joshua T; Landweber, Laura F

    2016-01-01

    The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture that is present in approximately 10% of all enzymes. It is generally assumed that this ubiquity in modern proteomes reflects an essential historical role in early protein-mediated metabolism. Here, we provide quantitative and comparative analyses to support several hypotheses about the early importance of the TIM barrel architecture. An information theoretical analysis of protein structures supports the hypothesis that the TIM barrel architecture could arise more easily by duplication and recombination compared to other mixed α/β structures. We show that TIM barrel enzymes corresponding to the most taxonomically broad superfamilies also have the broadest range of functions, often aided by metal and nucleotide-derived cofactors that are thought to reflect an earlier stage of metabolic evolution. By comparison to other putatively ancient protein architectures, we find that the functional diversity of TIM barrel proteins cannot be explained simply by their antiquity. Instead, the breadth of TIM barrel functions can be explained, in part, by the incorporation of a broad range of cofactors, a trend that does not appear to be shared by proteins in general. These results support the hypothesis that the simple and functionally general TIM barrel architecture may have arisen early in the evolution of protein biosynthesis and provided an ideal scaffold to facilitate the metabolic transition from ribozymes, peptides, and geochemical catalysts to modern protein enzymes.

  11. FAKTOR-FAKTOR YANG MEMENGARUHI PERILAKU PRODUKTIF MAHASISWA FAKULTAS EKONOMI ANGKATAN TAHUN 2013

    Directory of Open Access Journals (Sweden)

    Rheza Hafid Prastia

    2017-02-01

    Full Text Available Education is an important element for undergraduate students to encourage a positive economic attitude. Basically, undergraduate students are not being a consumer only, but also are expected to be able to serve as a producer by processing a resources arround themselves maximally. Within this research, likert scale questionnaire is used as an instrument and tested in terms of validity and reliability in undergraduate students of Faculty of Economics Universitas Negeri Malang 2013. The sample of this study was 304 undergraduate students. The data analysis was conducted using SEM technique through Lisrel 8.80 program. The results indicated that economic education in the family has no influence upon the self-efficacy. Moreover, financial literacy does not influence to the self-efficacy and economic rationality influences self-efficacy. In addition, self-efficacy influences productive attitude of the students, economic education in family influences productive attitude of the students. However, economic education in family does not influence productive attitude through self-efficacy as well as financial literasi which does not influence productive attitude through self-efficacy. While economic rationality influneces productive attitude through self-efficacy. Pentingnya pendidikan yang diberikan kepada seorang mahasiswa adalah untuk mendorong munculnya perilaku yang baik dalam hal ekonomi. Pada dasarnya setiap mahasiswa tidak hanya berperan sebagai konsumen saja, melainkan juga bertindak sebagai produsen yang berperilaku produktif dengan cara mampu mengolah sumber daya yang ada di sekitarnya untuk dimanfaatkan secara maksimal. Sebelum penelitian, angket yang digunakan sebagai instrumen penelitian dengan skala likert terlebih dahulu di uji validitas dan reliabilitasnya pada mahasiswa Fakultas Ekonomi Universitas Negeri Malang angkatan 2013. Sebanyak 304 mahasiswa menjadi sampel dalam penelitian dan menggunakan teknik analisis SEM dengan bantuan program

  12. Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4.

    Science.gov (United States)

    Tietjen, Gregory T; Gong, Zhiliang; Chen, Chiu-Hao; Vargas, Ernesto; Crooks, James E; Cao, Kathleen D; Heffern, Charles T R; Henderson, J Michael; Meron, Mati; Lin, Binhua; Roux, Benot; Schlossman, Mark L; Steck, Theodore L; Lee, Ka Yee C; Adams, Erin J

    2014-04-15

    Recognition of phosphatidylserine (PS) lipids exposed on the extracellular leaflet of plasma membranes is implicated in both apoptotic cell removal and immune regulation. The PS receptor T cell immunoglobulin and mucin-domain-containing molecule 4 (Tim4) regulates T-cell immunity via phagocytosis of both apoptotic (high PS exposure) and nonapoptotic (intermediate PS exposure) activated T cells. The latter population must be removed at lower efficiency to sensitively control immune tolerance and memory cell population size, but the molecular basis for how Tim4 achieves this sensitivity is unknown. Using a combination of interfacial X-ray scattering, molecular dynamics simulations, and membrane binding assays, we demonstrate how Tim4 recognizes PS in the context of a lipid bilayer. Our data reveal that in addition to the known Ca(2+)-coordinated, single-PS binding pocket, Tim4 has four weaker sites of potential ionic interactions with PS lipids. This organization makes Tim4 sensitive to PS surface concentration in a manner capable of supporting differential recognition on the basis of PS exposure level. The structurally homologous, but functionally distinct, Tim1 and Tim3 are significantly less sensitive to PS surface density, likely reflecting the differences in immunological function between the Tim proteins. These results establish the potential for lipid membrane parameters, such as PS surface density, to play a critical role in facilitating selective recognition of PS-exposing cells. Furthermore, our multidisciplinary approach overcomes the difficulties associated with characterizing dynamic protein/membrane systems to reveal the molecular mechanisms underlying Tim4's recognition properties, and thereby provides an approach capable of providing atomic-level detail to uncover the nuances of protein/membrane interactions.

  13. Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer

    Science.gov (United States)

    Gao, Quanli; Yuan, Peng; Zhao, Peng; Yuan, Huijuan; Fan, Huijie; Li, Tiepeng; Qin, Peng; Han, Lu; Fang, Weijia; Suo, Zhenhe

    2015-01-01

    T-cell exhaustion represents a progressive loss of T-cell function. The inhibitory receptor PD-1 is known to negatively regulate CD8+ T cell responses directed against tumor antigen, but the blockades of PD-1 pathway didn't show the objective responses in patients with colorectal cancer (CRC). Thus, further exploring the molecular mechanism responsible for inducing T-cell dysfunction in CRC patients may reveal effective strategies for immune therapy. This study aims to characterize co-inhibitory receptors on T cells in CRC patients to identify novel targets for immunotherapy. In this study, peripheral blood samples from 20 healthy controls and 54 consented CRC patients, and tumor and matched paraneoplastic tissues from 7 patients with advanced CRC, subjected to multicolor flow cytometric analysis of the expression of PD-1 and Tim-3 receptors on CD8+ T cells. It was found that CRC patients presented with significantly higher levels of circulating Tim-3+PD-1+CD8+ T cells compared to the healthy controls (medians of 3.12% and 1.99%, respectively, p = 0.0403). A similar increase of Tim-3+PD-1+CD8+ T cells was also observed in the tumor tissues compared to paraneoplastic tussues. Tim-3+PD-1+CD8+ T cells in tumor tissues produced even less cytokine than that in paraneoplastic tissues. Functional ex vivo experiments showed that Tim-3+PD-1+CD8+ T cells produced significantly less IFN-γ than Tim-3−PD-1−CD8+ T cells, followed by Tim-3+PD-1−CD8+ T cells, and Tim-3−PD-1+CD8+ T cells, indicating a stronger inhibition of IFN-γ production of Tim-3+CD8+ T cells. It is also found in this study that Tim-3+PD-1+CD8+ T cell increase in circulation was correlated with clinical cancer stage but not histologic grade and serum concentrations of cancer biomarker CEA. Our results indicate that upregulation of the inhibitory receptor Tim-3 may restrict T cell responses in CRC patients, and therefore blockage of Tim-3 and thus restoring T cell responses may be a potential

  14. PENGARUH BRAND IMAGE DAN BRAND AWARENESS TERHADAP MINAT PEMBELIAN SMARTPHONE APPLE IPHONE (Studi pada Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Hasanuddin)

    OpenAIRE

    -, ANDI FACHRUL DESTAMA

    2017-01-01

    ABSTRAK PENGARUH BRAND IMAGE DAN BRAND AWARENESS TERHADAP MINAT PEMBELIAN SMARTPHONE APPLE IPHONE (Studi pada Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Hasanuddin) THE INFLUENCE OF BRAND IMAGE AND BRAND AWARENESS TO THE PURCHASE INTENTION OF APPLE IPHONE SMARTPHONE (Study on Students of Economic and Business Faculty, Hasanuddin University) Andi Fachrul Destama Muh. Asdar Abdul Razak Munir Penelitian ini bertujuan untuk mengetahui sejauh mana pengaruh Bran...

  15. Novel effector phenotype of Tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients.

    Science.gov (United States)

    Liu, Zhuqing; McMichael, Elizabeth L; Shayan, Gulidanna; Li, Jing; Chen, Kevin; Srivastava, Raghvendra M; Kane, Lawrence P; Lu, Binfeng; Ferris, Robert L

    2018-04-30

    Regulatory T (Treg) cells are important suppressive cells among tumor infiltrating lymphocytes (TIL). Treg express the well-known immune checkpoint receptor PD-1, which is reported to mark "exhausted" Treg with lower suppressive function. T cell immunoglobulin mucin (Tim)-3, a negative regulator of Th1 immunity, is expressed by a sizeable fraction of TIL Tregs, but the functional status of Tim-3+ Tregs remains unclear. CD4+CTLA-4+CD25high Treg were sorted from freshly excised head and neck squamous cell carcinoma (HNSCC) TIL based on Tim-3 expression. Functional and phenotypic features of these Tim-3+ and Tim-3- TIL Tregs were tested by in vitro suppression assays and multi-color flow cytometry. Gene expression profiling and NanoString analysis of Tim-3+ TIL Treg were performed. A murine HNSCC tumor model was used to test the effect of anti-PD-1 immunotherapy on Tim-3+ Treg.  Results: Despite high PD-1 expression, Tim-3+ TIL Treg displayed a greater capacity to inhibit naïve T cell proliferation than Tim-3- Treg. Tim-3+ Treg from human HNSCC TIL also displayed an effector-like phenotype, with more robust expression of CTLA-4, PD-1, CD39 and IFN-γ receptor. Exogenous IFN-γ treatment could partially reverse the suppressive function of Tim-3+ TIL Treg. Anti-PD-1 immunotherapy downregulated Tim-3 expression on Tregs isolated from murine HNSCC tumors, and this treatment reversed the suppressive function of HNSCC TIL Tregs. Tim-3+ Treg are functionally and phenotypically distinct in HNSCC TIL, and are highly effective at inhibiting T cell proliferation despite high PD-1 expression.  IFN-γ induced by anti-PD-1 immunotherapy may be beneficial by reversing Tim-3+ Treg suppression. Copyright ©2018, American Association for Cancer Research.

  16. Anticipating Deep Mapping: Tracing the Spatial Practice of Tim Robinson

    Directory of Open Access Journals (Sweden)

    Jos Smith

    2015-07-01

    Full Text Available There has been little academic research published on the work of Tim Robinson despite an illustrious career, first as an artist of the London avant-garde, then as a map-maker in the west of Ireland, and finally as an author of place. In part, this dearth is due to the difficulty of approaching these three diverse strands collectively. However, recent developments in the field of deep mapping encourage us to look back at the continuity of Robinson’s achievements in full and offer a suitable framework for doing so. Socially engaged with living communities and a depth of historical knowledge about place, but at the same time keen to contribute artistically to the ongoing contemporary culture of place, the parameters of deep mapping are broad enough to encompass the range of Robinson’s whole practice and suggest unique ways to illuminate his very unusual career. But Robinson’s achievements also encourage a reflection on the historical context of deep mapping itself, as well as on the nature of its spatial practice (especially where space comes to connote a medium to be worked rather than an area/volume. With this in mind the following article both explores Robinson’s work through deep mapping and deep mapping through the work of this unusual artist.

  17. Sensor 17 Thermal Isolation Mounting Structure (TIMS) Design Improvements

    Energy Technology Data Exchange (ETDEWEB)

    Enstrom, K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-09-04

    The SENSOR 17 thermographic camera weighs approximately 0.5lbs, has a fundamental mode of 167 Hz, and experiences 0.75W of heat leakage in through the TIMS. The configuration, shown in Figure 1, is comprised of four 300 Series SST washers paired in tandem with P.E.I (Ultem 100) washers. The SENSOR 17 sensor is mounted to a 300 series stainless plate with A-shaped arms. The Plate can be assumed to be at ambient temperatures (≈293K) and the I.R. Mount needs to be cooled to 45K. It is attached to the tip of a cryocooler by a ‘cold strap’ and is assumed to be at the temperature of the cold-strap (≈45K). During flights SENSOR 17 experiences excitations at frequencies centered around 10-30Hz, 60Hz, and 120Hz from the aircraft flight environment. The temporal progression described below depicts the 1st Modal shape at the systems resonant frequency. This simulation indicates Modal articulation will cause a pitch rate of the camera with respect to the body axis of the airplane. This articulation shows up as flutter in the camera.

  18. Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm

    Directory of Open Access Journals (Sweden)

    Patrick Younan

    2017-09-01

    Full Text Available Ebola virus (EBOV disease (EVD results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1 has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1−/− mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected. Tim-1−/− mice exhibited a modified inflammatory response as evidenced by changes in serum cytokines and activation of T helper subsets. A series of in vitro assays based on the Tim-1 expression profile on T cells demonstrated that despite the apparent absence of detectable viral replication in T lymphocytes, EBOV directly binds to isolated T lymphocytes in a phosphatidylserine–Tim-1-dependent manner. Exposure to EBOV resulted in the rapid development of a CD4Hi CD3Low population, non-antigen-specific activation, and cytokine production. Transcriptome and Western blot analysis of EBOV-stimulated CD4+ T cells confirmed the induction of the Tim-1 signaling pathway. Furthermore, comparative analysis of transcriptome data and cytokine/chemokine analysis of supernatants highlight the similarities associated with EBOV-stimulated T cells and the onset of a cytokine storm. Flow cytometry revealed virtually exclusive binding and activation of central memory CD4+ T cells. These findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of EVD.

  19. Taming dendritic cells with TIM-3: Another immunosuppressive strategy by tumors

    Science.gov (United States)

    Patel, Jaina; Bozeman, Erica N.; Selvaraj, Periasamy

    2013-01-01

    The identification of TIM-3 expression on tumor associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells, however its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 mAb treated mice or mice depleted of all DCs which indicated that significant role played by TADCs inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings. PMID:23240746

  20. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.

    Science.gov (United States)

    Meertens, Laurent; Carnec, Xavier; Lecoin, Manuel Perera; Ramdasi, Rasika; Guivel-Benhassine, Florence; Lew, Erin; Lemke, Greg; Schwartz, Olivier; Amara, Ali

    2012-10-18

    Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, the molecular interactions mediating DV entry are poorly understood. We determined that TIM and TAM proteins, two receptor families that mediate the phosphatidylserine (PtdSer)-dependent phagocytic removal of apoptotic cells, serve as DV entry factors. Cells poorly susceptible to DV are robustly infected after ectopic expression of TIM or TAM receptors. Conversely, DV infection of susceptible cells is inhibited by anti-TIM or anti-TAM antibodies or knockdown of TIM and TAM expression. TIM receptors facilitate DV entry by directly interacting with virion-associated PtdSer. TAM-mediated infection relies on indirect DV recognition, in which the TAM ligand Gas6 acts as a bridging molecule by binding to PtdSer within the virion. This dual mode of virus recognition by TIM and TAM receptors reveals how DVs usurp the apoptotic cell clearance pathway for infectious entry. Copyright © 2012 Elsevier Inc. All rights reserved.

  1. Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

    Energy Technology Data Exchange (ETDEWEB)

    Cai, X.Z. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang (China); Huang, W.Y.; Qiao, Y.; Chen, Y.; Du, S.Y.; Chen, D.; Yu, S. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Liu, N. [Department of Nephrology, First Affiliated Hospital, China Medical University, Shenyang (China); Dou, L.Y. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Jiang, Y. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang (China); Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang (China)

    2014-10-17

    The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P<0.001). No significant differences in TIM family protein expression were observed in leukocytes from SLE patients and healthy controls (P>0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (r{sub s}=0.283, P=0.049) and serum albumin (r{sub s}=0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; r{sub s}=-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE.

  2. Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

    International Nuclear Information System (INIS)

    Cai, X.Z.; Huang, W.Y.; Qiao, Y.; Chen, Y.; Du, S.Y.; Chen, D.; Yu, S.; Liu, N.; Dou, L.Y.; Jiang, Y.

    2014-01-01

    The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P<0.001). No significant differences in TIM family protein expression were observed in leukocytes from SLE patients and healthy controls (P>0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (r s =0.283, P=0.049) and serum albumin (r s =0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; r s =-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE

  3. FAKTOR FAKTOR YANG MEMPENGARUHI PERSEPSI MAHASISWA TENTANG MATA KULIAH KEWIRAUSAHAAN DI FAKULTAS ILMU ADMINISTRASI UNIVERSITAS LANCANG KUNING PEKANBARU

    Directory of Open Access Journals (Sweden)

    Abdul Mirad

    2016-09-01

    Full Text Available Abstrak Penelitian ini dilaksanakan di Fakultas Ilmu Administrasi Universitas  Lancang Kuning Pekanbaru,Dengan jangka waktu Penelitian 3 (tiga   Bulan. Dimana populasi dan sampelnya berjumlah 42  orang terdiri dari mahasiswa semesterVII kelas pagi Fia Unilak.Teknik pengambilan sampel menggunakan teknik sensus. Jenis data yang diambil dalam penelitian ini meliputi data ,  pengalaman masa lalu,keyakinan,dan pengalaman orang lain Konsep teori yang digunakan menggunakan konsep Vincent Gaspers.  Analisis data dalam penelitian ini menggunakan analisis deskriptif kualitatif. Penelitian ini didanai oleh Fakultas Ilmu Administrasi dengan dana  serjumlah 3 (tiga Juta rupiahHasil penelitian tentang Persepsi Mahasiswa Tentang Mata Kuliah Kewirausahaan Di Fakultas Ilmu Administrasi Universitas Lancang Kuning Pekanbaru adalah Cukup Baik dengan tanggapan sebanyak 18 responden atau 41,67 % memberikan tanggapan Cukup Baik dimana indikator yang paling dominan adalah pengalaman masa lalu sebanyak tanggapan 19 responden atau 42,52 %  Saran dalam penelitian ini adalah Untuk menciptakan dan memberikan pandangan kepada responden yang merupakan kader-kader muda dalam berusaha untuk menjalankan bisnis wirausaha yang diinginkan mengingat ketatnya persaingan dunia kerja sehingga berwirausaha merupakan salah satunya jalan yang harus ditempuh.dan Kepada semua pihak agar dapat bekerja sama membentuk kader wirausaha yang handal di lingkungan Universitas Lancang Kuning Pekanbaru. Kata kunci :persepsi mahasiswa, kewirausahaan Abstract                 This research was held at the Faculty of Administrative Sciences Lancang Kuning Pekanbaru, with a period of study of 3 (three months. Where the population and the sample amounted to 42 people consisting of morning class students of semester VII Fia Unilak. The sampling technique are using census. Type of data that collected in this study includes data, past experiences, beliefs, and experiences of others

  4. Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.

    Science.gov (United States)

    Jang, A Reum; Moravcevic, Katarina; Saez, Lino; Young, Michael W; Sehgal, Amita

    2015-02-01

    Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA repression in the molecular feedback loop. In Drosophila, nuclear entry of the clock proteins, PERIOD (PER) and TIMELESS (TIM), is tightly controlled, and impairments of this process produce profound behavioral phenotypes. We report here that nuclear entry of PER-TIM in clock cells, and consequently behavioral rhythms, require a specific member of a classic nuclear import pathway, Importin α1 (IMPα1). In addition to IMPα1, rhythmic behavior and nuclear expression of PER-TIM require a specific nuclear pore protein, Nup153, and Ran-GTPase. IMPα1 can also drive rapid and efficient nuclear expression of TIM and PER in cultured cells, although the effect on PER is mediated by TIM. Mapping of interaction domains between IMPα1 and TIM/PER suggests that TIM is the primary cargo for the importin machinery. This is supported by attenuated interaction of IMPα1 with TIM carrying a mutation previously shown to prevent nuclear entry of TIM and PER. TIM is detected at the nuclear envelope, and computational modeling suggests that it contains HEAT-ARM repeats typically found in karyopherins, consistent with its role as a co-transporter for PER. These findings suggest that although PER is the major timekeeper of the clock, TIM is the primary target of nuclear import mechanisms. Thus, the circadian clock uses specific components of the importin pathway with a novel twist in that TIM serves a karyopherin-like role for PER.

  5. Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3).

    Science.gov (United States)

    Homayouni, Vida; Ganjalikhani-Hakemi, Mazdak; Rezaei, Abbas; Khanahmad, Hossein; Behdani, Mahdi; Lomedasht, Fatemeh Kazemi

    2016-11-01

    As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. We immunized a camel with TIM-3 antigen and then, synthesized a VHH phage: mid library from its B cell's transcriptome using nested PCR. Library selection against TIM-3antigen was performed in three rounds of panning. Using phage-ELISA, the most reactive colonies were selected for sub-cloning in soluble protein expression vectors. The Nanobody was purified and confirmed with a nickel-nitrilotriacetic acid (Ni-NTA) column, SDS-PAGE and Western blotting. A flowcytometric analysis was performed to analyze the binding and biologic activities of theTIM-3 specific nanobody with TIM-3 expressing HL-60 and HEK cell lines. Specific 15kD band representing for nanobody was observed on the gel and confirmed with Western blotting. The nanobody showed significant specific immune-reactivity against TIM-3 with a relatively high binding affinity. The nanobody significantly suppressed the proliferation of TIM-3 expressing HL-60 cell line. Finally, we successfully prepared a functional anti-humanTIM-3 specific nanobody with a high affinity and an anti-proliferative activity on an AML cell line in vitro.

  6. Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm.

    Science.gov (United States)

    Younan, Patrick; Iampietro, Mathieu; Nishida, Andrew; Ramanathan, Palaniappan; Santos, Rodrigo I; Dutta, Mukta; Lubaki, Ndongala Michel; Koup, Richard A; Katze, Michael G; Bukreyev, Alexander

    2017-09-26

    Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a "cytokine storm." Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1) has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1 -/- mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected. Tim-1 -/- mice exhibited a modified inflammatory response as evidenced by changes in serum cytokines and activation of T helper subsets. A series of in vitro assays based on the Tim-1 expression profile on T cells demonstrated that despite the apparent absence of detectable viral replication in T lymphocytes, EBOV directly binds to isolated T lymphocytes in a phosphatidylserine-Tim-1-dependent manner. Exposure to EBOV resulted in the rapid development of a CD4 Hi CD3 Low population, non-antigen-specific activation, and cytokine production. Transcriptome and Western blot analysis of EBOV-stimulated CD4 + T cells confirmed the induction of the Tim-1 signaling pathway. Furthermore, comparative analysis of transcriptome data and cytokine/chemokine analysis of supernatants highlight the similarities associated with EBOV-stimulated T cells and the onset of a cytokine storm. Flow cytometry revealed virtually exclusive binding and activation of central memory CD4 + T cells. These findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of EVD. IMPORTANCE Ebola virus infection is characterized by a massive release of inflammatory mediators, which has come to be known as a cytokine storm. The severity of the cytokine storm is

  7. TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

    Directory of Open Access Journals (Sweden)

    Wenwen Du

    2017-03-01

    Full Text Available Cancer immunotherapy has produced impressive clinical results in recent years. Despite the success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4 and programmed death receptor 1 (PD-1, a large portion of cancer patients have not yet benefited from this novel therapy. T cell immunoglobulin and mucin domain 3 (TIM-3 has been shown to mediate immune tolerance in mouse models of infectious diseases, alloimmunity, autoimmunity, and tumor Immunity. Thus, targeting TIM-3 emerges as a promising approach for further improvement of current immunotherapy. Despite a large amount of experimental data showing an immune suppressive function of TIM-3 in vivo, the exact mechanisms are not well understood. To enable effective targeting of TIM-3 for tumor immunotherapy, further in-depth mechanistic studies are warranted. These studies will also provide much-needed insight for the rational design of novel combination therapy with other checkpoint blockers. In this review, we summarize key evidence supporting an immune regulatory role of TIM-3 and discuss possible mechanisms of action.

  8. ANALISIS TREND KINERJA PENGAJARAN DOSEN FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA MULAI TAHUN 2010 s.d 2015

    Directory of Open Access Journals (Sweden)

    Achmad Fauzi

    2016-03-01

    Full Text Available Amid the college competition, where public universities are entering a new form of Public Service Agency (BLU, the public universities increasingly in demand to provide more quality services. Hence the focus on service improvement mainly lecturers teaching activities need to be improved from year to year.The better for its existence, the Faculty of Economics UNJ, should run higher education quality assurance has collected. then one way that can be achieved is by doing research on students regarding the level of student satisfaction on the performance of the teaching faculty of Economics diFakultas UNJ. The purpose of this study is to provide an overview of trends faculty performance and give impetus to occur padai improved performance in the coming years. The results of this study are brought average performance trend in the teaching faculty in each department is good, which is the average value moves above trend figures 3,0dengan the conclusion that the students of the Faculty of Economics satisfied with the performance of the teaching lecturer.

  9. EVALUASI PEMANFAATAN JURNAL DALAM DATABASE "EBSCO BIOMEDICAL REFERENCE COLLECTION" DI UNIT PERPUSTAKAAN DAN INFORMATIKA KEDOKTERAN (UPIK FAKULTAS KEDOKTERAN UGM YOGYAKARTA

    Directory of Open Access Journals (Sweden)

    Eka Wardhani S.

    2015-12-01

    Full Text Available Evaluasi terhadap pemanfaatan koleksi sangat diperlukan untuk mengetahui seberapa besar koleksi tersebut diakses dan dimanfaatkan oleh pengguna. Ebsco Biomedical Reference Collection (Ebsco BRC merupakan salah satu database jurnal yang berparadigma akses. Evaluasi pemanfaatan jurnal dalam database Ebsco BRC merupakan penelitian tentang pemanfaatan koleksi perpustakaan yang dilakukan di UPIK (Unit Perpustakaan dan Informatika Kedokteran Fakultas Kedokteran Universitas Gadjah Mada Yogyakarta. Penelitian ini bertujuan untuk mengetahui tingkat keterpakaian dan pemanfaatan jumal oleh sivitas akademika di FK UGM. Evaluasi dilakukan dengan metode deskriptif dengan pendekatan data kuantitatif dan kualitatif. . Instrumen yang digunakan dalam evaluasi adalah kuesioner dan usage statistics report. Hasil Penelitian ini menunjukkan bahwa tingkat keterpakaian jurnal berdasarkan judul yang ada tinggi (97,96%, akan tetapi tingkat pengaksesannya belum dilakukan secara maksimal. Rata-rata pengaksesan jurnal setiap harinya 25%. Dari data usage statistics report dapat diketahui sebanyak 12 judul jumal yang diakses lebih dari 1000 kali yang dinyatakan sebagai jumal yang paling sering diakses oleh pengguna. Saran peneliti berdasarkan hasil penelitian yang diperoleh adalah bahwa kegiatan melanggan koleksi database Ebsco dapat terus dilakukan , akan tetapi UPIK harus berusaha meningkatkan sosialisasi koleksi, aksesibilitas, fasilitas, dan bimbingan bagi pengguna dalam melakukan penelusuran dalam database tersebut agar dapat dimanfaatkan secara maksimal. Kata Kunci: Evaluasi Koleksi, Ebsco

  10. Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS

    Energy Technology Data Exchange (ETDEWEB)

    Garabedian, Alyssa; Benigni, Paolo; Ramirez, Cesar; Baker, Erin M.; Liu, Tao; Smith, Richard D.; Fernandez-Lima, Francisco

    2018-05-01

    Abstract. In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150–250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMSCID- TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow. The TIMS-TOF MS analysis permitted peptide biomarker detection based on accurate mobility, mass measurements, and high sequence coverage for concentrations in the 10–200 nM range, while simultaneously achieving discovery measurements

  11. TIM, a ray-tracing program for METATOY research and its dissemination

    Science.gov (United States)

    Lambert, Dean; Hamilton, Alasdair C.; Constable, George; Snehanshu, Harsh; Talati, Sharvil; Courtial, Johannes

    2012-03-01

    TIM (The Interactive METATOY) is a ray-tracing program specifically tailored towards our research in METATOYs, which are optical components that appear to be able to create wave-optically forbidden light-ray fields. For this reason, TIM possesses features not found in other ray-tracing programs. TIM can either be used interactively or by modifying the openly available source code; in both cases, it can easily be run as an applet embedded in a web page. Here we describe the basic structure of TIM's source code and how to extend it, and we give examples of how we have used TIM in our own research. Program summaryProgram title: TIM Catalogue identifier: AEKY_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKY_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 124 478 No. of bytes in distributed program, including test data, etc.: 4 120 052 Distribution format: tar.gz Programming language: Java Computer: Any computer capable of running the Java Virtual Machine (JVM) 1.6 Operating system: Any; developed under Mac OS X Version 10.6 RAM: Typically 145 MB (interactive version running under Mac OS X Version 10.6) Classification: 14, 18 External routines: JAMA [1] (source code included) Nature of problem: Visualisation of scenes that include scene objects that create wave-optically forbidden light-ray fields. Solution method: Ray tracing. Unusual features: Specifically designed to visualise wave-optically forbidden light-ray fields; can visualise ray trajectories; can visualise geometric optic transformations; can create anaglyphs (for viewing with coloured "3D glasses") and random-dot autostereograms of the scene; integrable into web pages. Running time: Problem-dependent; typically seconds for a simple scene.

  12. A quantitative analysis of TIMS data obtained on the Learjet 23 at various altitudes

    Science.gov (United States)

    Jaggi, S.

    1992-01-01

    A series of Thermal Infrared Multispectral Scanner (TIMS) data acquisition flights were conducted on the NASA Learjet 23 at different altitudes over a test site. The objective was to monitor the performance of the TIMS (its estimation of the brightness temperatures of the ground scene) with increasing altitude. The results do not show any significant correlation between the brightness temperatures and the altitude. The analysis indicates that the estimation of the temperatures is a function of the accuracy of the atmospheric correction used for each altitude.

  13. Smart Mirrors for Photorefractive Control of Light with Tim Bunning, RX - Agile Filters Application

    Science.gov (United States)

    2016-11-08

    AFRL-AFOSR-UK-TR-2017-0008 Smart Mirrors for photorefractive control of light with Tim Bunning, RX-- Agile filters application Luciano De Sio...DATE (DD-MM-YYYY)      10-02-2017 2. REPORT TYPE Final 3. DATES COVERED (From - To) 01 Feb 2014 to 31 Jan 2016 4. TITLE AND SUBTITLE Smart Mirrors for...photorefractive control of light with Tim Bunning, RX-- Agile filters application 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-14-1-0050 5c.  PROGRAM

  14. Analysis of Eocene depositional environments - Preliminary TM and TIMS results, Wind River Basin, Wyoming

    Science.gov (United States)

    Stucky, Richard K.; Krishtalka, Leonard; Redline, Andrew D.; Lang, Harold R.

    1987-01-01

    Both Landsat TM and aircraft Thermal IR Multispectral Scanner (TIMS) data have been used to map the lithofacies of the Wind River Basin's Eocene physical and biological environments. Preliminary analyses of these data have furnished maps of a fault contact boundary and a complex network of fluvial ribbon channel sandstones. The synoptic view thereby emerging for Eocene fluvial facies clarifies the relationships of ribbon channel sandstones to fossil-bearing overbank/floodplain facies and certain peleosols. The utility of TM and TIMS data is thereby demonstrated.

  15. A polymorphism of the TIM-1 IgV domain: implications for the susceptibility to filovirus infection.

    Science.gov (United States)

    Kuroda, Makoto; Fujikura, Daisuke; Noyori, Osamu; Kajihara, Masahiro; Maruyama, Junki; Miyamoto, Hiroko; Yoshida, Reiko; Takada, Ayato

    2014-12-12

    Filoviruses, including Ebola and Marburg viruses, cause severe hemorrhagic fever in humans and nonhuman primates with mortality rates of up to 90%. Human T-cell immunoglobulin and mucin domain 1 (TIM-1) is one of the host proteins that have been shown to promote filovirus entry into cells. In this study, we cloned TIM-1 genes from three different African green monkey kidney cell lines (Vero E6, COS-1, and BSC-1) and found that TIM-1 of Vero E6 had a 23-amino acid deletion and 6 amino acid substitutions compared with those of COS-1 and BSC-1. Interestingly, Vero E6 TIM-1 had a greater ability to promote the infectivity of vesicular stomatitis viruses pseudotyped with filovirus glycoproteins than COS-1-derived TIM-1. We further found that the increased ability of Vero E6 TIM-1 to promote virus infectivity was most likely due to a single amino acid difference between these TIM-1s. These results suggest that a polymorphism of the TIM-1 molecules is one of the factors that influence cell susceptibility to filovirus infection, providing a new insight into the molecular basis for the filovirus host range. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

    Science.gov (United States)

    Nozaki, Yuji; Nikolic-Paterson, David J; Snelgrove, Sarah L; Akiba, Hisaya; Yagita, Hideo; Holdsworth, Stephen R; Kitching, A Richard

    2012-05-01

    The T-cell immunoglobulin mucin 1 (Tim-1) modulates CD4(+) T-cell responses and is also expressed by damaged proximal tubules in the kidney where it is known as kidney injury molecule-1 (Kim-1). We sought to define the role of endogenous Tim-1 in experimental T-cell-mediated glomerulonephritis induced by sheep anti-mouse glomerular basement membrane globulin acting as a planted foreign antigen. Tim-1 is expressed by infiltrating activated CD4(+) cells in this model, and we studied the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) on immune responses and glomerular disease. Crescentic glomerulonephritis, proliferative injury, and leukocyte accumulation were attenuated following treatment with anti-Tim-1 antibodies, but interstitial foxp3(+) cell accumulation and interleukin-10 mRNA were increased. T-cell proliferation and apoptosis decreased in the immune system along with a selective reduction in Th1 and Th17 cellular responses both in the immune system and within the kidney. The urinary excretion and renal expression of Kim-1 was reduced by anti-Tim-1 antibodies reflecting diminished interstitial injury. The effects of anti-Tim-1 antibodies were not apparent in the early phase of renal injury, when the immune response to sheep globulin was developing. Thus, endogenous Tim-1 promotes Th1 and Th17 nephritogenic immune responses and its neutralization reduces renal injury while limiting inflammation in cell-mediated glomerulonephritis.

  17. Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.

    Science.gov (United States)

    Du, Xianhong; Wu, Zhuanchang; Xu, Yong; Liu, Yuan; Liu, Wen; Wang, Tixiao; Li, Chunyang; Zhang, Cuijuan; Yi, Fan; Gao, Lifen; Liang, Xiaohong; Ma, Chunhong

    2018-05-07

    As an immune checkpoint, Tim-3 plays roles in the regulation of both adaptive and innate immune cells including macrophages and is greatly involved in chronic liver diseases. However, the precise roles of Tim-3 in nonalcoholic steatohepatitis (NASH) remain unstated. In the current study, we analyzed Tim-3 expression on different subpopulations of liver macrophages and further investigated the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice. The results of flow cytometry demonstrated the significantly increased expression of Tim-3 on all detected liver macrophage subsets in MCD mice, including F4/80 + CD11b + , F4/80 + CD68 + , and F4/80 + CD169 + macrophages. Remarkably, Tim-3 knockout (KO) significantly accelerated MCD-induced liver steatosis, displaying higher serum ALT, larger hepatic vacuolation, more liver lipid deposition, and more severe liver fibrosis. Moreover, compared with wild-type C57BL/6 mice, Tim-3 KO MCD mice demonstrated an enhanced expression of NOX2, NLRP3, and caspase-1 p20 together with increased generation of IL-1β and IL-18 in livers. In vitro studies demonstrated that Tim-3 negatively regulated the production of reactive oxygen species (ROS) and related downstream pro-inflammatory cytokine secretion of IL-1β and IL-18 in macrophages. Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD. In conclusion, Tim-3 is a promising protector in MCD-induced steatohepatitis by controlling ROS and the associated pro-inflammatory cytokine production in macrophages.

  18. Servicing the first web server - Tim Berners-Lee's NeXT

    CERN Multimedia

    unknown, Association aBCM

    2009-01-01

    In August 2009 a team from the Association aBCM in Lausanne came to CERN to give the world's first web server a health check under the watchful eye of web pioneer Robert Cailliau. They took an image of the hard drive at this time, copies of which were given to Robert Cailliau and Tim Berners-Lee.

  19. Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS

    Science.gov (United States)

    Garabedian, Alyssa; Benigni, Paolo; Ramirez, Cesar E.; Baker, Erin S.; Liu, Tao; Smith, Richard D.; Fernandez-Lima, Francisco

    2017-09-01

    In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150-250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMS-CID-TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow. The TIMS-TOF MS analysis permitted peptide biomarker detection based on accurate mobility, mass measurements, and high sequence coverage for concentrations in the 10-200 nM range, while simultaneously achieving discovery measurements of not initially targeted peptides as markers from the same proteins and, eventually, other proteins. [Figure not available: see fulltext.

  20. TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens

    Directory of Open Access Journals (Sweden)

    Yoshihisa Hiraishi

    2016-10-01

    Conclusions: Our findings indicate that, in mice, TIM-3 is not essential for development of HDM-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM-induced chronic allergic airway inflammation.

  1. Consumerism, Activism, Intrinsic Motivation, and Balance: An Interview with Tim Kasser

    Science.gov (United States)

    Keeley, Jared

    2010-01-01

    A year after receiving his PhD in psychology from the University of Rochester, Tim Kasser accepted a position at Knox College, in Galesburg, Illinois, where he is currently professor of psychology. He regularly teaches psychology classes on personality, clinical and abnormal psychology, dreaming, and research methods, as well as an…

  2. Tim Allen, one of Hollywood's top comedy actors with Rolf Landua from CERN

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Tim Allen ('Galaxy Quest', 'For Richer and Poorer', 'The Santa Clause', Voice of 'Buzz Lightyear', in Toy Story 1 and 2), visited CERN in July 2000. He has a keen interest in modern physics. In his last book "I'm not really here" he contemplates the funny and the intriguing aspects of quantum physics in his daily life.

  3. The Filmmaker as Humanist: An Interview with Tim Robbins on the Making of "Cradle Will Rock".

    Science.gov (United States)

    Mason, Terrence C.

    2000-01-01

    Presents an interview with Tim Robbins that focuses on the making of the film "Cradle Will Rock." Robbins offers his perspectives on issues such as the power of art to convey important social messages and sources of violence in schools. Includes resources for teachers. (CMK)

  4. El De imaginibus caelestibus de Ibn al-Ḥātim

    Directory of Open Access Journals (Sweden)

    Oliveras, Marc

    2009-06-01

    Full Text Available K. Lippincott and D. Pingree published in 1987 a first Latin edition and English translation of the 15th bilingual Arabic-Latin De imaginibus caelestibus, written originally by the Andalusian Ibn al-Ḥātim in the 10th century. The paper presented here aims to complete the preceding one with an Arabic edition, Spanish translation and some interpretations on the possible sources of talismanic imagery. In this brief astromagic treatise, Ibn al-Ḥātim focuses on twenty eight talismans, related to the lunar mansions, and their magical properties.

    En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥātim se dedica principalmente a describir veintiocho talismanes, relacionados con las mansiones lunares, y sus propiedades mágicas.

  5. Suppression of TIM-1 predicates clinical efficacy of sublingual immunotherapy for allergic rhinitis in children.

    Science.gov (United States)

    Lin, Zhibin; Zhou, Lifeng; Luo, Xi; Xia, Wentong; Chen, Dehua; Xu, Rui; Wang, Jie; Luo, Renzhong; Xu, Geng; Li, Huabin

    2013-08-01

    To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) with house-dust mite (HDM) extract and to examine the change of biomarkers (TIM-1, IL-5 and IL-10) after 6-month SLIT in children with allergic rhinitis (AR). One hundred and sixteen HDM-sensitized children with persistent AR were enrolled to assess the clinical efficacy of SLIT by determining the individual nasal symptom score (INSS) and total nasal symptom scores (TNSS) after 6-month SLIT. Moreover, the mRNA expression of TIM-1, IL-5 and IL-10 in peripheral blood mononuclear cells (PBMCs) was examined in 16 well-controlled and 12 uncontrolled AR patients using quantitative reverse transcription polymerase chain reaction (qRT-PCR). After 6-month SLIT, both TNSS and INSS scores were significantly decreased compared with the baseline value (p < 0.01). The rates for well-controlled, partly controlled and uncontrolled children were 43.1%, 32.8% and 24.1%, respectively. Accordingly, the mRNA levels of TIM-1 and IL-5 decreased significantly and IL-10 mRNA level increased significantly compared with the baseline value in well-controlled children (p < 0.05). Our findings suggest SLIT with HDM extract is effective and safe for AR children and TIM-1 may be considered as an indicator for evaluating the clinical efficacy of SLIT. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  6. Onsite: A Residency with Tim Rollins/KOS. A Photo Essay.

    Science.gov (United States)

    Placky, Robert

    2000-01-01

    Presents a photo essay that visually narrates the workshop that took place in State College, Pennsylvania, from October 19-24, 1998 bringing together middle and high school students with Tim Rollins, who is a conceptual artist and educator, and Kids of Survival (KOS). (CMK)

  7. Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria.

    Science.gov (United States)

    Popov-Celeketić, Dusan; Mapa, Koyeli; Neupert, Walter; Mokranjac, Dejana

    2008-05-21

    The TIM23 (translocase of the mitochondrial inner membrane) complex mediates translocation of preproteins across and their insertion into the mitochondrial inner membrane. How the translocase mediates sorting of preproteins into the two different subcompartments is poorly understood. In particular, it is not clear whether association of two operationally defined parts of the translocase, the membrane-integrated part and the import motor, depends on the activity state of the translocase. We established conditions to in vivo trap the TIM23 complex in different translocation modes. Membrane-integrated part of the complex and import motor were always found in one complex irrespective of whether an arrested preprotein was present or not. Instead, we detected different conformations of the complex in response to the presence and, importantly, the type of preprotein being translocated. Two non-essential subunits of the complex, Tim21 and Pam17, modulate its activity in an antagonistic manner. Our data demonstrate that the TIM23 complex acts as a single structural and functional entity that is actively remodelled to sort preproteins into different mitochondrial subcompartments.

  8. T-bet-mediated Tim-3 expression dampens monocyte function during chronic hepatitis C virus infection.

    Science.gov (United States)

    Yi, Wenjing; Zhang, Peixin; Liang, Yan; Zhou, Yun; Shen, Huanjun; Fan, Chao; Moorman, Jonathan P; Yao, Zhi Q; Jia, Zhansheng; Zhang, Ying

    2017-03-01

    Hepatitis C virus (HCV) induces a high rate of chronic infection via dysregulation of host immunity. We have previously shown that T-cell immunoglobulin and mucin domain protein-3 (Tim-3) is up-regulated on monocyte/macrophages (M/Mφ) during chronic HCV infection; little is known, however, about the transcription factor that controls its expression in these cells. In this study, we investigated the role of transcription factor, T-box expressed in T cells (T-bet), in Tim-3 expression in M/Mφ in the setting of HCV infection. We demonstrate that T-bet is constitutively expressed in resting CD14 + M/Mφ in the peripheral blood. M/Mφ from chronically HCV-infected individuals exhibit a significant increase in T-bet expression that positively correlates with an increased level of Tim-3 expression. Up-regulation of T-bet is also observed in CD14 + M/Mφ incubated with HCV + Huh7.5 cells, as well as in primary M/Mφ or monocytic THP-1 cells exposed to HCV core protein in vitro, which is reversible by blocking HCV core/gC1qR interactions. Moreover, the HCV core-induced up-regulation of T-bet and Tim-3 expression in M/Mφ can be abrogated by incubating the cells with SP600125 - an inhibitor for the c-Jun N-terminal kinase (JNK) signalling pathway. Importantly, silencing T-bet gene expression decreases Tim-3 expression and enhances interleukin-12 secretion as well as signal transducer and activator of transcription 1 phosphorylation. These data suggest that T-bet, induced by the HCV core/gC1qR interaction, enhances Tim-3 expression via the JNK pathway, leading to dampened M/Mφ function during HCV infection. These findings reveal a novel mechanism for Tim-3 regulation via T-bet during HCV infection, providing new targets to combat this global epidemic viral disease. © 2016 John Wiley & Sons Ltd.

  9. Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins.

    Science.gov (United States)

    Romero-Romero, Sergio; Costas, Miguel; Rodríguez-Romero, Adela; Alejandro Fernández-Velasco, D

    2015-08-28

    Temperature is one of the main variables that modulate protein function and stability. Thermodynamic studies of oligomeric proteins, the dominant protein natural form, have been often hampered because irreversible aggregation and/or slow reactions are common. There are no reports on the reversible equilibrium thermal unfolding of proteins composed of (β/α)8 barrel subunits, albeit this "TIM barrel" topology is one of the most abundant and versatile in nature. We studied the eponymous TIM barrel, triosephosphate isomerase (TIM), belonging to five species of different bacterial taxa. All of them were found to be catalytically efficient dimers. The three-dimensional structure of four enzymes was solved at high/medium resolution. Irreversibility and kinetic control were observed in the thermal unfolding of two TIMs, while for the other three the thermal unfolding was found to follow a two-state equilibrium reversible process. Shifts in the global stability curves of these three proteins are related to the organismal temperature range of optimal growth and modulated by variations in maximum stability temperature and in the enthalpy change at that temperature. Reversibility appears to correlate with the low isoelectric point, the absence of a residual structure in the unfolded state, small cavity volume in the native state, low conformational stability and a low melting temperature. Furthermore, the strong coupling between dimer dissociation and monomer unfolding may reduce aggregation and favour reversibility. It is therefore very thought-provoking to find that a common topological ensemble, such as the TIM barrel, can unfold/refold in the Anfinsen way, i.e. without the help of the cellular machinery.

  10. TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity

    Science.gov (United States)

    Angiari, Stefano; Donnarumma, Tiziano; Rossi, Barbara; Dusi, Silvia; Pietronigro, Enrica; Zenaro, Elena; Della Bianca, Vittorina; Toffali, Lara; Piacentino, Gennj; Budui, Simona; Rennert, Paul; Xiao, Sheng; Laudanna, Carlo; Casasnovas, Jose M.; Kuchroo, Vijay K.; Constantin, Gabriela

    2014-01-01

    SUMMARY Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper-1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 IgV domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease. PMID:24703780

  11. Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3

    Directory of Open Access Journals (Sweden)

    Vida Homayouni

    2016-11-01

    Full Text Available Objective(s: As T-cell immunoglobulin and mucin domain 3 (TIM-3 is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Methods:We immunized a camel with TIM-3 antigen and then, synthesized a VHH phagemid library from its B cell’s transcriptome using nested PCR. Library selection against TIM-3antigen was performed in three rounds of panning. Using phage-ELISA, the most reactive colonies were selected for sub-cloning in soluble protein expression vectors. The Nanobody was purified and confirmed with a nickel-nitrilotriacetic acid (Ni-NTA column, SDS-PAGE and Western blotting. A flowcytometric analysis was performed to analyze the binding and biologic activities of theTIM-3 specific nanobody with TIM-3 expressing HL-60 and HEK cell lines. Results:Specific 15kD band representing for nanobody was observed on the gel and confirmed with Western blotting. The nanobody showed significant specific immune-reactivity against TIM-3 with a relatively high binding affinity. The nanobody significantly suppressed the proliferation of TIM-3 expressing HL-60 cell line. Conclusion: Finally, we successfully prepared a functional anti-humanTIM-3 specific nanobody with a high affinity and an anti-proliferative activity on an AML cell line in vitro.

  12. Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease.

    Science.gov (United States)

    Tang, Zhao-Hui; Liang, Shuwen; Potter, James; Jiang, Xuan; Mao, Hai-Quan; Li, Zhiping

    2013-02-15

    T cell Ig and mucin domain (Tim)-3 is well known to interact with its natural ligand, Galectin-9 (Gal-9), to regulate T cell function. However, little is known about the function of Tim-3/Gal-9 signaling in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) mediated by hepatic NKT cells that also express Tim-3. In the current study, we define the role and the mechanism of Tim-3/Gal-9 signaling in hepatic NKT cell regulation in a mouse model of diet-induced NAFLD. Adult male wild-type or CD1d knockout C57BL/6 mice were fed a high-fat diet to induce steatosis. Some of the mice also received one or a combination of Gal-9, anti-IL-15R/IL-15 mAb, rIL-15, α-galactosylceramide, and multilamellar liposomes containing Cl(2)MDP. The expression of Tim-3 and various markers reflecting cell proliferation, activation, cytokine production, and apoptosis was analyzed. Liver histology, steatosis grade, and hepatic triglyceride content were also evaluated. In the liver, Tim-3(+) NKT cells are in an activated state, and Gal-9 directly induces Tim-3(+) NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. However, Gal-9 also interacts with Tim-3-expressing Kupffer cells to induce secretion of IL-15, thus promoting NKT cell proliferation. Exogenous administration of Gal-9 significantly ameliorates diet-induced steatosis by modulating hepatic NKT cell function. In summary, the Tim-3/Gal-9-signaling pathway plays a critical role in the homeostasis of hepatic NKT cells through activation-induced apoptosis and secondary proliferation and, thus, contributes to the pathogenesis of NAFLD.

  13. Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease

    Science.gov (United States)

    Liang, Shuwen; Potter, James; Jiang, Xuan; Mao, Hai-Quan

    2013-01-01

    T cell Ig and mucin domain (Tim)-3 is well known to interact with its natural ligand, Galectin-9 (Gal-9), to regulate T cell function. However, little is known about the function of Tim-3/Gal-9 signaling in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) mediated by hepatic NKT cells that also express Tim-3. In the current study, we define the role and the mechanism of Tim-3/Gal-9 signaling in hepatic NKT cell regulation in a mouse model of diet-induced NAFLD. Adult male wild-type or CD1d knockout C57BL/6 mice were fed a high-fat diet to induce steatosis. Some of the mice also received one or a combination of Gal-9, anti–IL-15R/IL-15 mAb, rIL-15, α-galactosylceramide, and multilamellar liposomes containing Cl2MDP. The expression of Tim-3 and various markers reflecting cell proliferation, activation, cytokine production, and apoptosis was analyzed. Liver histology, steatosis grade, and hepatic triglyceride content were also evaluated. In the liver, Tim-3+ NKT cells are in an activated state, and Gal-9 directly induces Tim-3+ NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. However, Gal-9 also interacts with Tim-3–expressing Kupffer cells to induce secretion of IL-15, thus promoting NKT cell proliferation. Exogenous administration of Gal-9 significantly ameliorates diet-induced steatosis by modulating hepatic NKT cell function. In summary, the Tim-3/Gal-9–signaling pathway plays a critical role in the homeostasis of hepatic NKT cells through activation-induced apoptosis and secondary proliferation and, thus, contributes to the pathogenesis of NAFLD. PMID:23296703

  14. A multipurpose TIM-based optical telescope for Omega and the Trident laser facilities

    International Nuclear Information System (INIS)

    Oertel, J.A.; Murphy, T.J.; Berggren, R.R.

    1998-01-01

    The authors have recently designed and are building a telescope which acts as an imaging light collector relaying the image to an optical table for experiment dependent analysis and recording. The expected primary use of this instrument is a streaked optical pyrometer for witness plate measurements of Hohlraum drive temperature. The telescope is based on University of Rochester's Ten-Inch Manipulator (TIM) which allows compatibility between Omega, Trident, and the NIF lasers. The optics capture a f/7 cone of light, have a field of view of 6-mm, have a spatial resolution of 5 to 7-microm per line pair at the object plane, and are optimized for operation at 280-nm. The image is at a magnification of 11.7x, which is convenient for many experiments, but can be changed using additional optics that reside outside the TIM

  15. Effect of difference between group constants processed by codes TIMS and ETOX on integral quantities

    International Nuclear Information System (INIS)

    Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

    1978-06-01

    Group constants of 235 U, 238 U, 239 Pu, 240 Pu and 241 Pu have been produced with the processing code TIMS using the evaluated nuclear data of JENDL-1. The temperature and composition dependent self-shielding factors have been calculated for the two cases with and without considering mutual interference resonant nuclei. By using the group constants set produced by the TIMS code, the integral quantities, i.e. multiplication factor, Na-void reactivity effect and Doppler reactivity effect, are calculated and compared with those calculated with the use of the cross sections set produced by the ETOX code to evaluate accuracy of the approximate calculation method in ETOX. There is much difference in self-shielding factor in each energy group between the two codes. For the fast reactor assemblies under study, however, the integral quantities calculated with these two sets are in good agreement with each other, because of eventual cancelation of errors. (auth.)

  16. Järgmise lainega võivad tulla meile Ühendriikide investorid / Tim Ferland ; interv. Margit Aedla

    Index Scriptorium Estoniae

    Ferland, Tim

    2003-01-01

    Eestis asuva Ameerika Kaubanduskoja (ACCE) president Tim Ferland analüüsib Eesti senist arengut, EL-iga liitumise mõju tulevasele majanduslikule arengule, Eesti ning USA majandus- ja kaubandussuhete olukorda

  17. Book review: Social Research: Issues, Methods and Process, 3rd edition, by Tim May, Open University Press, 2001, ISBN 0335206123

    OpenAIRE

    Jones, Keith

    2004-01-01

    The great strength of this book by Tim May ("Social Research: Issues, Methods and Process", 3rd edition ) is its successful negotiation (perhaps navigation) of the relationships between theory and method in (social) research.

  18. Application of TIMS in isotope correlations for determining the isotope ratios of plutonium

    International Nuclear Information System (INIS)

    Alamelu, D.; Aggarwal, S.K.

    2003-01-01

    Thermal ionisation mass spectrometry (TIMS) is a well-recognized technique for determining the isotopic composition of Pu in irradiated nuclear fuel samples. Other mass spectrometric methods such as ICPMS, SIMS can also be employed for the isotopic analysis of Pu. In the event of non-availability of a mass spectrometer, other techniques such as gamma spectrometry and alpha spectrometry can also be used. They have a limited applicability since data on all the Pu isotopes cannot be obtained

  19. Insights into the fold organization of TIM barrel from interaction energy based structure networks.

    Science.gov (United States)

    Vijayabaskar, M S; Vishveshwara, Saraswathi

    2012-01-01

    There are many well-known examples of proteins with low sequence similarity, adopting the same structural fold. This aspect of sequence-structure relationship has been extensively studied both experimentally and theoretically, however with limited success. Most of the studies consider remote homology or "sequence conservation" as the basis for their understanding. Recently "interaction energy" based network formalism (Protein Energy Networks (PENs)) was developed to understand the determinants of protein structures. In this paper we have used these PENs to investigate the common non-covalent interactions and their collective features which stabilize the TIM barrel fold. We have also developed a method of aligning PENs in order to understand the spatial conservation of interactions in the fold. We have identified key common interactions responsible for the conservation of the TIM fold, despite high sequence dissimilarity. For instance, the central beta barrel of the TIM fold is stabilized by long-range high energy electrostatic interactions and low-energy contiguous vdW interactions in certain families. The other interfaces like the helix-sheet or the helix-helix seem to be devoid of any high energy conserved interactions. Conserved interactions in the loop regions around the catalytic site of the TIM fold have also been identified, pointing out their significance in both structural and functional evolution. Based on these investigations, we have developed a novel network based phylogenetic analysis for remote homologues, which can perform better than sequence based phylogeny. Such an analysis is more meaningful from both structural and functional evolutionary perspective. We believe that the information obtained through the "interaction conservation" viewpoint and the subsequently developed method of structure network alignment, can shed new light in the fields of fold organization and de novo computational protein design.

  20. Tim, Jan Lucas ja Karl Robert - vennad üheks kuuks / Maris Laurits

    Index Scriptorium Estoniae

    Laurits, Maris

    2009-01-01

    Rakvere Teatri suvelavastuse "Vennad Lõvisüdamed" kaks Karli osatäitjat Jan Lucas Videvik ja Tim Leesnurm ning Joonatani osatäitja Karl Robert Saaremäe tegid Loksal Kaldmaa talus ratsasõiduproove. Üllar Saaremäe lavastuse "Vennad Lõvisüdamed" (Astrid Lindgreni samanimelise jutustuse järgi) esietendus on 11. juunil Rakvere teatri taga aias

  1. PENGARUH KEMAMPUAN BACA TULIS AL-QUR’AN TERHADAP HASIL BELAJAR TAFSIR MAHASISWA FAKULTAS TARBIYAH DAN KEGURUAN UIN ALAUDDIN MAKASSAR

    Directory of Open Access Journals (Sweden)

    Nuryamin Nuryamin

    2015-06-01

    Full Text Available Abstract: This study aimed to determine the effect of the ability to read and write al Quran on Tafseer learning achievement of the second semester students of the Department of Islamic Education and Teaching Faculty UIN Alauddin Makassar academic in year 2013/2014. The method used was quantitative. The variables in this research was the ability to read and write the Koran (X, and Tafseer learning achievement (Y. The population in this study is the second semester students of 2013/2014. The number of respondents were 40 students that was taken by using purposive sampling. The analysis technique used to answer the hypothesis in this study was a descriptive and simple regression analysis. The results showed that the ability to read and write the Koran (X did not significantly affect the Tafseer learning achievement with the R2 values of 0.081 and 0.075 was the level of significance. The implications of this research is that UIN Alauddin Makassar give much more attention to improve the students’ ability to read and write the Koran. Therefore, it can provide quality improvement of the students themselves. Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh kemampuan baca tulis al-Qur’an terhadap hasil belajar tafsir mahasiswa semester II angkatan 2013/2014 Jurusan Pendidikan Agama Islam Fakultas Tarbiyah dan Keguruan UIN Alauddin Makassar. Metode penelitian yang digunakan ialah kuantitatif. Varia-bel dalam penelitian ini adalah Kemampuan baca tulis al-Qur’an (X, dan hasil belajar tafsir (Y. Populasi dalam penelitian ini adalah maha­siswa semester II angaktan 2013/2014. Jumlah responden sebanyak 40 Mahasiswa dengan memakai purposive sampling. Adapun teknik analisis yang digunakan untuk men­jawab hipotesis dalam penelitian ini adalah metode analisis deskriptif dan analisis regresi sederhana. Hasil penelitian menunjukkan bahwa kemampuan baca tulis al-Qur’an (X berpengaruh namun tidak signifikan terhadap nilai hasil belajar tafsir

  2. Determination of La and Nd by thermal ionization mass spectrometry (TIMS) pre-separated by high performance liquid chromatography (HPLC)

    International Nuclear Information System (INIS)

    Jaison, P.G.; Raut, N.M.; Parab, A.R.; Khodade, P.S.; Govindan, R.; Aggarwal, S.K.

    2003-01-01

    Determination of La and Nd by TIMS is required for accurate determination of burn-up of nuclear fuels. During their thermal ionization mass spectrometric (TIMS) analysis, 138 Ce and 142 Ce show spectroscopic isobaric interferences at 138 La and 142 Nd, respectively. Hence, it is essential to remove Ce from La and Nd for their accurate isotopic composition determination. Reversed phase high performance liquid chromatography (HPLC) is a promising technique for rapid and effective separation

  3. The TimBel synchronization board for time resolved experiments at synchrotron SOLEIL

    International Nuclear Information System (INIS)

    Ricaud, J.P.; Betinelli-Deck, P.; Bisou, J.; Elattaoui, X.; Laulhe, C.; Monteiro, P.; Nadolski, L.S.; Renaud, G.; Ravy, S.; Silly, M.; Sirotti, F.

    2012-01-01

    Time resolved experiments are one of the major services that synchrotrons can provide to scientists. The short, high frequency and regular flashes of synchrotron light are a fantastic tool to study the evolution of phenomena over time. To carry out time resolved experiments, beamlines need to synchronize their devices with these flashes of light with a jitter shorter than the pulse duration. For that purpose, Synchrotron SOLEIL has developed the TimBeL (Timing Beamlines) board fully interfaced to TANGO framework. The TimBeL system is a compact PCI board. It is made of a mother with one daughter board. All functions are performed inside a FPGA (Field Programmable Gate Array) implemented on the mother board. A PLX Technology chip is used to communicate with the compact PCI crate. To enable experiments to remain always synchronous with the same bunch of electrons, the storage ring clock (CLK-SR) and the radio frequency clock (CLK-RF) are provided by the machine to beamlines. These clocks are used inside the FPGA as main clocks for state machines. Because the jitter is too large on the FPGA outputs, a daughter board with a jitter cleaner has been added to the system. This board also provides delay lines for compensating time offsets by 10 ps steps. This paper presents the main features required by time resolved experiments and how we achieved our goals with the TimBeL board

  4. Performance characteristics of a Bioassay method for plutonium using thermal ionisation mass spectrometry (TIMS)

    Energy Technology Data Exchange (ETDEWEB)

    Linauskas, S.H.; Elliot, N.L.; Paterson, L.M.; Totland, M.M

    2003-01-01

    Plutonium-in-urine analysis by radiochemical isolation of Pu followed by thermal ionisation mass spectrometry (TIMS) is capable of high sensitivity and precision measurements {sup 239}Pu and {sup 240}Pu. Bias and precision estimates for the TIMS bioassay program at Chalk River Laboratories easily met the ANSI N13.30 performance criteria standards with {sup 239}Pu results of 1.5% and 3.0%, respectively. Analytical blanks derived from water, artificial urine and true urine samples did not produce any statistically different results. During a four-year period of development and implementation of {sup 239}Pu measurements by TIMS, average sample blank values were reduced from 3.9 fg (9.0 {mu}Bq) to 0.57 fg (1.3 {mu}Bq). This reduction was achieved through rigorous application of clean-room handling techniques throughout sample processing. Blank data were found to follow a Iognormal distribution, and current detection limit parameters for L{sub c} and L{sub d} at the 95% significance levels are 0.85 fg {sup 239}Pu (2.0 {mu}Bq) and 1.3 fg {sup 239}Pu (3.0 {mu}Bq), respectively. Detection limits in this range are expected to be sufficient to identify intakes of Pu/Am mixtures at levels that are around one-twentieth of an ALl or better under routine monitoring situations for ICRP Type S and Type M inhalation solubility classes. (author)

  5. PENGARUH KEBUTUHAN TERHADAP MOTIF PENGGUNAAN KARTU DEBET BANK CENTRAL ASIA (BCA DI KALANGAN MAHASISWA AKTIF FAKULTAS EKONOMI UNIVERSITAS KRISTEN PETRA SURABAYA

    Directory of Open Access Journals (Sweden)

    Hatane Semuel

    2003-01-01

    Full Text Available This research is conducted to the students of class 1999, 2000, and 2001 of Economics Faculty of Petra Christian University. This research focuses on cognitive and affective motive of those subjects in using BCA's debit card, assuming that consumers tend to use objective and subjective factors in considering to purchase certain product. The result of this research shows that achievement needs, power needs, and affiliation needs simultaneously influence the motive of the subjects in using BCA's debit card, in which 46% of the influence can be explained by the model. Achievement needs have more dominant influence compared to power needs. Besides that, education factor (study duration found to influence the cognitive motive, which is shown by the motive difference among class 1999, 2000, and 2001. Abstract in Bahasa Indonesia : Penelitian dilakukan terhadap mahasiswa Fakultas ekonomi Universitas Kristen PETRA Surabaya angkatan 1999, 2000, dan 2001. Fokus penelitian pada motif kognitif dan afektif dalam menggunakan produk kartu debet BCA, dengan asumsi bahwa konsumen dalam mempertimbangkan pembelian suatu produk lebih didasarkan pada faktor obyektif dan subyektif. Hasil penelitian mengungkapkan kebutuhan yang diukur melalui, achievement needs, power needs, affiliation needs ternyata secara serempak berpengaruh terhadap motif penggunaan kartu debet BCA di kalangan mahasiswa Fakultas Ekonomi Universitas Kristen PETRA Surabaya, dengan kemampuan 46% dapat dijelaskan dari dalam model. Achievement needs mempunyai pengaruh lebih dominan dibandingkan power needs. Selain itu faktor pendidikan (lama studi mempunyai dampak terhadap motif kognitif, hal ini terungkap dari adanya perbedaan motif tersebut pada angkatan 1999 dengan angkatan 2000 maupun angkatan 2001. Kata kunci: motif, achievement, power, needs.

  6. Space Solar Power Exploratory Research and Technology (SERT) Technical Interchange Meeting 2 (SERT TIM 2)

    Science.gov (United States)

    Howell, Joe; Sanders, Clark W.

    2000-01-01

    The University of Alabama in Huntsville's (UAH) Propulsion Research Center hosted the Space Solar Power Exploratory Research & Technology (SERT) Technical Interchange Meeting TIM) 2 in Huntsville, Alabama December 7-10. 1999 with 126 people in attendance. The SERT program includes both competitively procured activities. which are being implemented through a portfolio of focused R&D investments--with the maximum leveraging of existing resources inside and outside NASA. and guided by these system studies. Axel Roth. Director of the Flight Projects Directorate NASA MSFC, welcomed the SERT TIM 2 participants and challenged them to develop the necessary technologies and demonstrations that will lead to Space Solar Power (SSP) International implementation. Joe Howell, NASA MSFC, reiterated the SERT TIM 2 objectives: 1) Refining and modeling systems approaches for the utilization of SSP concepts and technologies, ranging, from the near-term e.g. for space science, exploration and commercial space applications to the far-term (e. g. SSP for terrestrial markets), including systems concepts, technology, infrastructure (i.g., transportation), and economics. 2) Conducting technology research, development and demonstration activities to produce "proof- of-concept" validation of critical SSP elements for both the nearer and farther-term applications. 3) Initiating partnerships Nationality and Internationally that could be expanded, as appropriate, to pursue later SSP technology and applications (e.g., space science. colonization, etc.). Day one began with the NASA Centers presenting their SERT activities summary since SERT TIM 1 and wound up with a presentation by Masahiro Mori, NASDA titled "NASDA In-house Study for SSP". Demonstration for the Near-Term. Day two began with the SERT Systems Studies and Analysis reports resulting from NRA 8-23 followed by presentations of SERT Technology Demonstrations reports resulting from NRA 8-23. Day two closed with John Mankins presentation

  7. TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.

    Directory of Open Access Journals (Sweden)

    Brian Tomkowicz

    Full Text Available TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3 is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells. Recent studies indicate that TIM-3 serves as a negative regulator of T cell function (i.e. T cell dependent immune responses, proliferation, tolerance, and exhaustion. Despite having no recognizable inhibitory signaling motifs, the intracellular tail of TIM-3 is apparently indispensable for function. Specifically, the conserved residues Y265/Y272 and surrounding amino acids appear to be critical for function. Mechanistically, several studies suggest that TIM-3 can associate with interleukin inducible T cell kinase (ITK, the Src kinases Fyn and Lck, and the p85 phosphatidylinositol 3-kinase (PI3K adaptor protein to positively or negatively regulate IL-2 production via NF-κB/NFAT signaling pathways. To begin to address this discrepancy, we examined the effect of TIM-3 in two model systems. First, we generated several Jurkat T cell lines stably expressing human TIM-3 or murine CD28-ECD/human TIM-3 intracellular tail chimeras and examined the effects that TIM-3 exerts on T cell Receptor (TCR-mediated activation, cytokine secretion, promoter activity, and protein kinase association. In this model, our results demonstrate that TIM-3 inhibits several TCR-mediated phenotypes: i NF-kB/NFAT activation, ii CD69 expression, and iii suppression of IL-2 secretion. To confirm our Jurkat cell observations we developed a primary human CD8+ cell system that expresses endogenous levels of TIM-3. Upon TCR ligation, we observed the loss of NFAT reporter activity and IL-2 secretion, and identified the association of Src kinase Lck, and PLC-γ with TIM-3. Taken together, our results support the conclusion that TIM-3 is a negative regulator of TCR-function by attenuating activation signals mediated by CD3/CD28 co-stimulation.

  8. TIM1 (HAVCR1 Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

    Directory of Open Access Journals (Sweden)

    Anshuman Das

    2017-09-01

    Full Text Available Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1 is widely accepted to be the receptor for hepatitis A virus (HAV, an unusual, hepatotropic human picornavirus. However, its identification as the hepatovirus receptor predated the discovery that hepatoviruses undergo nonlytic release from infected cells as membrane-cloaked, quasi-enveloped HAV (eHAV virions that enter cells via a pathway distinct from naked, nonenveloped virions. We thus revisited the role of TIM1 in hepatovirus entry, examining both adherence and infection/replication in cells with clustered regularly interspaced short palindromic repeat (CRISPR/Cas9-engineered TIM1 knockout. Cell culture-derived, gradient-purified eHAV bound Huh-7.5 human hepatoma cells less efficiently than naked HAV at 4°C, but eliminating TIM1 expression caused no difference in adherence of either form of HAV, nor any impact on infection and replication in these cells. In contrast, TIM1-deficient Vero cells showed a modest reduction in quasi-enveloped eHAV (but not naked HAV attachment and replication. Thus, TIM1 facilitates quasi-enveloped eHAV entry in Vero cells, most likely by binding phosphatidylserine (PtdSer residues on the eHAV membrane. Both Tim1−/− Ifnar1−/− and Tim4−/− Ifnar1−/− double-knockout mice were susceptible to infection upon intravenous challenge with infected liver homogenate, with fecal HAV shedding and serum alanine aminotransferase (ALT elevations similar to those in Ifnar1−/− mice. However, intrahepatic HAV RNA and ALT elevations were modestly reduced in Tim1−/−Ifnar1−/− mice compared to Ifnar1−/− mice challenged with a lower titer of gradient-purified HAV or eHAV. We conclude that TIM1 is not an essential hepatovirus entry factor, although its PtdSer-binding activity may contribute to the spread of quasi-enveloped virus and liver injury in mice.

  9. Tim de Zeeuw to Become the Next Director General of ESO

    Science.gov (United States)

    2007-01-01

    The ESO Council has just appointed Tim de Zeeuw, 50, as the next Director General of ESO, effective as of 1 September 2007, when the current Director General, Catherine Cesarsky will complete her mandate. ESO PR Photo 02/07 ESO PR Photo 03/07 Professor Tim de Zeeuw "ESO is Europe's flagship organisation for ground-based astronomy," said, Richard Wade, President of the ESO Council. "The ESO Council is very pleased that Professor de Zeeuw has accepted the task as its next Director General. He has played a key role over the last few years in developing a strategic vision for ESO, and I have every confidence that he will now lead the organisation in the realisation of that exciting vision." Tim de Zeeuw has an excellent record, both as a highly respected scientist and as a leader of an internationally recognised science institute in the Netherlands. He is Scientific Director of the Leiden Observatory, a research institute in the College of Mathematics and Natural Sciences of Leiden University. Tim de Zeeuw also has considerable experience as regards science policy issues. Catherine Cesarsky, ESO's current Director General commented: "Over the recent years, ESO has developed considerably with more activities and new member states, and with its ambitious project portfolio, ESO is clearly facing an exciting future. I shall be delighted to pass the baton to Tim de Zeeuw, who as a recent Council member is very familiar with our Organisation." "It is a great honour and an exciting challenge to lead this world-class organisation in the years to come in support of one of the most dynamic areas of science today," said de Zeeuw. "I look forward to overseeing the continued upgrading of the Very Large Telescope with the second-generation instrumentation and the completion of the ALMA project, and in particular to help developing the future European Extremely Large Telescope." Tim de Zeeuw's main research interests embrace the formation, structure and dynamics of galaxies

  10. Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry.

    Science.gov (United States)

    Rhein, Bethany A; Brouillette, Rachel B; Schaack, Grace A; Chiorini, John A; Maury, Wendy

    2016-07-01

    Phosphatidylserine (PtdSer) receptors that are responsible for the clearance of dying cells have recently been found to mediate enveloped virus entry. Ebola virus (EBOV), a member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells. The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved PtdSer binding pocket within the amino-terminal IgV domain. While the residues within the TIM-1 IgV domain that are important for EBOV entry are characterized, the molecular details of virion-TIM-4 interactions have yet to be investigated. As sequences and structural alignments of the TIM proteins suggest distinct differences in the TIM-1 and TIM-4 IgV domain structures, we sought to characterize TIM-4 IgV domain residues required for EBOV entry. Using vesicular stomatitis virus pseudovirions bearing EBOV glycoprotein (EBOV GP/VSVΔG), we evaluated virus binding and entry into cells expressing TIM-4 molecules mutated within the IgV domain, allowing us to identify residues important for entry. Similar to TIM-1, residues in the PtdSer binding pocket of murine and human TIM-4 (mTIM-4 and hTIM-4) were found to be important for EBOV entry. However, additional TIM-4-specific residues were also found to impact EBOV entry, with a total of 8 mTIM-4 and 14 hTIM-4 IgV domain residues being critical for virion binding and internalization. Together, these findings provide a greater understanding of the interaction of TIM-4 with EBOV virions. With more than 28,000 cases and over 11,000 deaths during the largest and most recent Ebola virus (EBOV) outbreak, there has been increased emphasis on the development of therapeutics against filoviruses. Many therapies under investigation target EBOV cell entry. T-cell immunoglobulin mucin (TIM) domain proteins are cell surface factors important for the entry of many enveloped viruses

  11. PENGARUH PENGGUNAAN MEDIA SOSIAL INSTAGRAM TERHADAP CITRA TUBUH MAHASISWA FAKULTAS USHULUDDIN ADAB DAN DAKWAH IAIN PONOROGO TAHUN 2016

    Directory of Open Access Journals (Sweden)

    Nadia Faidatun Nasiha

    2017-12-01

    merasakan dampak pemakaian berkelanjutan dari media sosial tersebut. Dalam ilmu psikologi ada sebuah istilah baru yang dinamakan Citra Tubuh, yaitu konsep seseorang dalam menilai penampilan, cara pandang maupun sikap dari segi psikologis maupun biologis. Instagram banyak dimanfaatkan oleh individu maupun kelompok yang mencoba mengenalkan pakaian mereka secara online dan hal itu memudahkan seorang konsumen dengan mudah dalam mengakses model fashion  yang mereka inginkan. Penelitian ini akan mengungkap pengaruh instagram terhadap citra tubuh mahasiswa Fakultas Ushuluddin Adab dan Dakwah IAIN Ponorogo. Metode yang digunakan adalah penelitian kuantitatif, teknik pengumpulan data menggunakan angket. Untuk uji validitas menggunakan rumus product momentdan uji reliabilitas menggunakan rumus Spearman brown. Sedangkan pada tahap analisis data menggunakan analisis Regresi Linier Sederhana. Dari hasil analisa data, peneliti menyimpulkan bahwa 1 Penggunaan media sosial instagram mahasiswa Fakultas Ushuluddin Adab dan Dakwah IAIN Ponorogo adalah kategori sedang dengan prosentase 59,37%. 2 Tingkat citra tubuh mahasiswa Fakultas Ushuluddin Adab dan DakwahPonorogo adalah kategori sedang dengan prosentase 65,62%. 3 Terdapat pengaruh antara media sosial instagram terhadap citra tubuh mahasiswa Jurusan  Ushuluddin Adab dan Dakwah IAIN Ponorogo karena Fhitung (9,8550 lebih besar dari Ftabel (taraf signifikansi 1% = 7,56 dan taraf signifikansi 5% = 4,17.   Keywords : Media Sosial Instagram, Citra Tubuh

  12. Approaches to vegetation mapping and ecophysiological hypothesis testing using combined information from TIMS, AVIRIS, and AIRSAR

    Science.gov (United States)

    Oren, R.; Vane, G.; Zimmermann, R.; Carrere, V.; Realmuto, V.; Zebker, Howard A.; Schoeneberger, P.; Schoeneberger, M.

    1991-01-01

    The Tropical Rainforest Ecology Experiment (TREE) had two primary objectives: (1) to design a method for mapping vegetation in tropical regions using remote sensing and determine whether the result improves on available vegetation maps; and (2) to test a specific hypothesis on plant/water relations. Both objectives were thought achievable with the combined information from the Thermal Infrared Multispectral Scanner (TIMS), Airborne Visible/Infrared Imaging Spectrometer (AVIRIS), and Airborne Synthetic Aperture Radar (AIRSAR). Implicitly, two additional objectives were: (1) to ascertain that the range within each variable potentially measurable with the three instruments is large enough in the site, relative to the sensitivity of the instruments, so that differences between ecological groups may be detectable; and (2) to determine the ability of the three systems to quantify different variables and sensitivities. We found that the ranges in values of foliar nitrogen concentration, water availability, stand structure and species composition, and plant/water relations were large, even within the upland broadleaf vegetation type. The range was larger when other vegetation types were considered. Unfortunately, cloud cover and navigation errors compromised the utility of the TIMS and AVIRIS data. Nevertheless, the AIRSAR data alone appear to have improved on the available vegetation map for the study area. An example from an area converted to a farm is given to demonstrate how the combined information from AIRSAR, TIMS, and AVIRIS can uniquely identify distinct classes of land use. The example alludes to the potential utility of the three instruments for identifying vegetation at an ecological scale finer than vegetation types.

  13. LITERASI MEDIA SEBAGAI STRATEGI KOMUNIKASI TIM SUKSES RELAWAN PEMENANGAN PEMILIHAN PRESIDEN JOKOWI JK DI BANDUNG

    Directory of Open Access Journals (Sweden)

    Annisa Senova

    2016-12-01

    Full Text Available Memahami kegiatan literasi media yang terjadi dalam kehidupan berorganisasi akan memberikan gambaran yang jelas tentang kemampuan mengidentifikasi, menentukan, mengorganisir, dan menggunakan media, serta menjadikan informasi sebagai bahan pertimbangan pembuatan keputusan tim sukses relawan pemenangan Presiden Joko Widodo dan Jusuf Kalla di Bandung. Oleh karena itu, penelitian ini dilakukan untuk menemukan kegiatan literasi media sebagai strategi komunikasi tim sukses relawan pemenangan pemilihan presiden Joko Widodo dan Jusuf Kalla. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan pendekatan studi kasus. Penelitian ini menggunakan teknik pengumpulan data berupa wawancara mendalam, observasi, dan studi dokumentasi. Teknik pemeriksaan keabsahan data yang digunakan dalam penelitian ini adalah dengan triangulasi data sumber. Media sosial menjadi media utama dalam proses penyampaian pesan kepada khalayak di kota Bandung. Terdapat beberapa jenis media sosial yang akan digunakan secara rutin dalam proses tersebut, yaitu Twitter, Facebook, Instagram, dan Youtube. Namun, timses relawan media sosial hanya fokus kepada dua jenis media sosial yang dianggap dapat mempengaruhi pandangan publik. Twiter dan Instagram dianggap mampu menjadi jejaring sosial yang efektif dalam proses penyampaian pesan politik pemilu 2014. Penyampaian informasi oleh timses relawan media sosial kepada masyarakat melalui Twitter dan Instagram dianggap sangat efektif dan tepat. Konten-konten yang disediakan oleh akun Twitter sangat mudah untuk diakses oleh semua kalangan. Penelitian tantang proses literasi media tim sukses relawan pemenangan presiden Jokowi-Jk ini dapat menambah masukan bagi ilmu komunikasi, terutama dalam bidang literasi media, bahwa saat ini keberadaan media dapat menjadi sebuah strategi komunikasi yang cukup efektif.   DOI: 10.24198/jkk.vol4n2.3

  14. TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions.

    Science.gov (United States)

    Das, Anshuman; Hirai-Yuki, Asuka; González-López, Olga; Rhein, Bethany; Moller-Tank, Sven; Brouillette, Rachel; Hensley, Lucinda; Misumi, Ichiro; Lovell, William; Cullen, John M; Whitmire, Jason K; Maury, Wendy; Lemon, Stanley M

    2017-09-05

    Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. However, its identification as the hepatovirus receptor predated the discovery that hepatoviruses undergo nonlytic release from infected cells as membrane-cloaked, quasi-enveloped HAV (eHAV) virions that enter cells via a pathway distinct from naked, nonenveloped virions. We thus revisited the role of TIM1 in hepatovirus entry, examining both adherence and infection/replication in cells with clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-engineered TIM1 knockout. Cell culture-derived, gradient-purified eHAV bound Huh-7.5 human hepatoma cells less efficiently than naked HAV at 4°C, but eliminating TIM1 expression caused no difference in adherence of either form of HAV, nor any impact on infection and replication in these cells. In contrast, TIM1-deficient Vero cells showed a modest reduction in quasi-enveloped eHAV (but not naked HAV) attachment and replication. Thus, TIM1 facilitates quasi-enveloped eHAV entry in Vero cells, most likely by binding phosphatidylserine (PtdSer) residues on the eHAV membrane. Both Tim1 -/- Ifnar1 -/- and Tim4 -/- Ifnar1 -/- double-knockout mice were susceptible to infection upon intravenous challenge with infected liver homogenate, with fecal HAV shedding and serum alanine aminotransferase (ALT) elevations similar to those in Ifnar1 -/- mice. However, intrahepatic HAV RNA and ALT elevations were modestly reduced in Tim1 -/- Ifnar1 -/- mice compared to Ifnar1 -/- mice challenged with a lower titer of gradient-purified HAV or eHAV. We conclude that TIM1 is not an essential hepatovirus entry factor, although its PtdSer-binding activity may contribute to the spread of quasi-enveloped virus and liver injury in mice. IMPORTANCE T cell immunoglobulin and mucin-containing domain protein 1 (TIM1) was reported more than

  15. Ontology and anthropology of interanimality: Merleau-Ponty from Tim ingold's perspective

    Directory of Open Access Journals (Sweden)

    Ana Cristina Ramírez Barreto

    2010-01-01

    Full Text Available This essay explores Tim Ingold’s anthropological theory following his references to Merleau-Ponty and the concept of interanimality/interagentivity. It poses some ideas of Ingold’s “poetics of dwelling”, which he highlights from ethnographies of hunter-gatherer peoples, and how these ideas are linked to an ontological consideration which does not dissociate body and person, body and mind, nature and culture, animality and humanity. The paper reviews animal literature in Merleau-Ponty’s philosophy, and Ingold’s critique of “Anthropology of the senses”. It also gives critical clues for the ethical and political implications of this ontology.

  16. AVIRIS and TIMS data processing and distribution at the land processes distributed active archive center

    Science.gov (United States)

    Mah, G. R.; Myers, J.

    1993-01-01

    The U.S. Government has initiated the Global Change Research program, a systematic study of the Earth as a complete system. NASA's contribution of the Global Change Research Program is the Earth Observing System (EOS), a series of orbital sensor platforms and an associated data processing and distribution system. The EOS Data and Information System (EOSDIS) is the archiving, production, and distribution system for data collected by the EOS space segment and uses a multilayer architecture for processing, archiving, and distributing EOS data. The first layer consists of the spacecraft ground stations and processing facilities that receive the raw data from the orbiting platforms and then separate the data by individual sensors. The second layer consists of Distributed Active Archive Centers (DAAC) that process, distribute, and archive the sensor data. The third layer consists of a user science processing network. The EOSDIS is being developed in a phased implementation. The initial phase, Version 0, is a prototype of the operational system. Version 0 activities are based upon existing systems and are designed to provide an EOSDIS-like capability for information management and distribution. An important science support task is the creation of simulated data sets for EOS instruments from precursor aircraft or satellite data. The Land Processes DAAC, at the EROS Data Center (EDC), is responsible for archiving and processing EOS precursor data from airborne instruments such as the Thermal Infrared Multispectral Scanner (TIMS), the Thematic Mapper Simulator (TMS), and Airborne Visible and Infrared Imaging Spectrometer (AVIRIS). AVIRIS, TIMS, and TMS are flown by the NASA-Ames Research Center ARC) on an ER-2. The ER-2 flies at 65000 feet and can carry up to three sensors simultaneously. Most jointly collected data sets are somewhat boresighted and roughly registered. The instrument data are being used to construct data sets that simulate the spectral and spatial

  17. A field- and laboratory-based quantitative analysis of alluvium: Relating analytical results to TIMS data

    Science.gov (United States)

    Wenrich, Melissa L.; Hamilton, Victoria E.; Christensen, Philip R.

    1995-01-01

    Thermal Infrared Multispectral Scanner (TIMS) data were acquired over the McDowell Mountains northeast of Scottsdale, Arizona during August 1994. The raw data were processed to emphasize lithologic differences using a decorrelation stretch and assigning bands 5, 3, and 1 to red, green, and blue, respectively. Processed data of alluvium flanking the mountains exhibit moderate color variation. The objective of this study was to determine, using a quantitative approach, what environmental variable(s), in the absence of bedrock, is/are responsible for influencing the spectral properties of the desert alluvial surface.

  18. Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding

    Science.gov (United States)

    2013-01-01

    Background Human triosephosphate isomerase (HsTIM) deficiency is a genetic disease caused often by the pathogenic mutation E104D. This mutation, located at the side of an abnormally large cluster of water in the inter-subunit interface, reduces the thermostability of the enzyme. Why and how these water molecules are directly related to the excessive thermolability of the mutant have not been investigated in structural biology. Results This work compares the structure of the E104D mutant with its wild type counterparts. It is found that the water topology in the dimer interface of HsTIM is atypical, having a "wet-core-dry-rim" distribution with 16 water molecules tightly packed in a small deep region surrounded by 22 residues including GLU104. These water molecules are co-conserved with their surrounding residues in non-archaeal TIMs (dimers) but not conserved across archaeal TIMs (tetramers), indicating their importance in preserving the overall quaternary structure. As the structural permutation induced by the mutation is not significant, we hypothesize that the excessive thermolability of the E104D mutant is attributed to the easy propagation of atoms' flexibility from the surface into the core via the large cluster of water. It is indeed found that the B factor increment in the wet region is higher than other regions, and, more importantly, the B factor increment in the wet region is maintained in the deeply buried core. Molecular dynamics simulations revealed that for the mutant structure at normal temperature, a clear increase of the root-mean-square deviation is observed for the wet region contacting with the large cluster of interfacial water. Such increase is not observed for other interfacial regions or the whole protein. This clearly suggests that, in the E104D mutant, the large water cluster is responsible for the subunit interface flexibility and overall thermolability, and it ultimately leads to the deficiency of this enzyme. Conclusions Our study

  19. Una década de la Tarjeta de Identidad de Menores (TIM

    Directory of Open Access Journals (Sweden)

    Eugenia Ma. Zamora Chavarría

    2013-07-01

    Full Text Available El documento de identidad de las personas difiere de su derecho a la identidad, propiamente dicho; uno y otro se encuentran estrechamente relacionados y el primero tiene la virtud de acreditar, de una manera inmediata y directa, frente a la comunidad, al segundo. Este artículo ofrece una serie de reflexiones alrededor del derecho al nombre y al concepto de identidad. Se centra en el documento denominado Tarjeta de Identidad para Costarricenses de Doce a Dieciocho Años, conocida popularmente como la Ley TIM y repasa lo actuado por el Tribunal en relación con este documento.

  20. Second NASA Technical Interchange Meeting (TIM): Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box (TTB)

    Science.gov (United States)

    ONeil, D. A.; Mankins, J. C.; Christensen, C. B.; Gresham, E. C.

    2005-01-01

    The Advanced Technology Lifecycle Analysis System (ATLAS), a spreadsheet analysis tool suite, applies parametric equations for sizing and lifecycle cost estimation. Performance, operation, and programmatic data used by the equations come from a Technology Tool Box (TTB) database. In this second TTB Technical Interchange Meeting (TIM), technologists, system model developers, and architecture analysts discussed methods for modeling technology decisions in spreadsheet models, identified specific technology parameters, and defined detailed development requirements. This Conference Publication captures the consensus of the discussions and provides narrative explanations of the tool suite, the database, and applications of ATLAS within NASA s changing environment.

  1. La banda sonora del programa «Rá-Tim-Bum»

    OpenAIRE

    Almeida Duarte, Mônica de

    2005-01-01

    Esta comunicación trata de los resultados parciales de la investigación vuelta para el análisis de la banda sonora del programa televisivo Rá-Tim-Bum, de TV Educativa, empresa gubernamental. Se utiliza un cuadro teórico-metodológico de análisis de los discursos aplicado a la música propuesto por Amparo Porta por medio de tres niveles de aproximación: verosimilitud referencial (las calidades sonoras), poética (tratamiento de frases y de finalización) y tópica (ideologia difundida). El...

  2. High-precision isotopic characterization of USGS reference materials by TIMS and MC-ICP-MS

    Science.gov (United States)

    Weis, Dominique; Kieffer, Bruno; Maerschalk, Claude; Barling, Jane; de Jong, Jeroen; Williams, Gwen A.; Hanano, Diane; Pretorius, Wilma; Mattielli, Nadine; Scoates, James S.; Goolaerts, Arnaud; Friedman, Richard M.; Mahoney, J. Brian

    2006-08-01

    The Pacific Centre for Isotopic and Geochemical Research (PCIGR) at the University of British Columbia has undertaken a systematic analysis of the isotopic (Sr, Nd, and Pb) compositions and concentrations of a broad compositional range of U.S. Geological Survey (USGS) reference materials, including basalt (BCR-1, 2; BHVO-1, 2), andesite (AGV-1, 2), rhyolite (RGM-1, 2), syenite (STM-1, 2), granodiorite (GSP-2), and granite (G-2, 3). USGS rock reference materials are geochemically well characterized, but there is neither a systematic methodology nor a database for radiogenic isotopic compositions, even for the widely used BCR-1. This investigation represents the first comprehensive, systematic analysis of the isotopic composition and concentration of USGS reference materials and provides an important database for the isotopic community. In addition, the range of equipment at the PCIGR, including a Nu Instruments Plasma MC-ICP-MS, a Thermo Finnigan Triton TIMS, and a Thermo Finnigan Element2 HR-ICP-MS, permits an assessment and comparison of the precision and accuracy of isotopic analyses determined by both the TIMS and MC-ICP-MS methods (e.g., Nd isotopic compositions). For each of the reference materials, 5 to 10 complete replicate analyses provide coherent isotopic results, all with external precision below 30 ppm (2 SD) for Sr and Nd isotopic compositions (27 and 24 ppm for TIMS and MC-ICP-MS, respectively). Our results also show that the first- and second-generation USGS reference materials have homogeneous Sr and Nd isotopic compositions. Nd isotopic compositions by MC-ICP-MS and TIMS agree to within 15 ppm for all reference materials. Interlaboratory MC-ICP-MS comparisons show excellent agreement for Pb isotopic compositions; however, the reproducibility is not as good as for Sr and Nd. A careful, sequential leaching experiment of three first- and second-generation reference materials (BCR, BHVO, AGV) indicates that the heterogeneity in Pb isotopic compositions

  3. Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex.

    Science.gov (United States)

    Popov-Čeleketić, Dušan; Waegemann, Karin; Mapa, Koyeli; Neupert, Walter; Mokranjac, Dejana

    2011-06-01

    The TIM23 complex mediates translocation of proteins across, and their lateral insertion into, the mitochondrial inner membrane. Translocation of proteins requires both the membrane-embedded core of the complex and its ATP-dependent import motor. Insertion of some proteins, however, occurs in the absence of ATP, questioning the need for the import motor during lateral insertion. We show here that the import motor associates with laterally inserted proteins even when its ATPase activity is not required. Furthermore, our results suggest a role for the import motor in lateral insertion. Thus, the import motor is involved in ATP-dependent translocation and ATP-independent lateral insertion.

  4. DIFERENCE EFFICACY BETWEEN WINNER AND DEFEAT TIM ON WORLD CHAMPIONSHIP IN SOCCER GAME 2006

    Directory of Open Access Journals (Sweden)

    Alen Kapidžić

    2007-04-01

    Full Text Available We analyse thirty games of world championship in soccer 2006 with am to determine variables which contribute signifi cant distinction and differences between winner and defeat tim. Fortifi cation differences in aplayed variables we will apply multivariant analisis of variance. For this examination we will use variable of tehnich elements, and some of tactics calculation and estimate quality of tehnics elements according to the judges. This problem is very interesting for exploration, and it’s leading to modern tendency’s so these are the elementary reasons why we chose this kind of exploration.

  5. Earth-Mars Telecommunications and Information Management System (TIMS): Antenna Visibility Determination, Network Simulation, and Management Models

    Science.gov (United States)

    Odubiyi, Jide; Kocur, David; Pino, Nino; Chu, Don

    1996-01-01

    This report presents the results of our research on Earth-Mars Telecommunications and Information Management System (TIMS) network modeling and unattended network operations. The primary focus of our research is to investigate the feasibility of the TIMS architecture, which links the Earth-based Mars Operations Control Center, Science Data Processing Facility, Mars Network Management Center, and the Deep Space Network of antennae to the relay satellites and other communication network elements based in the Mars region. The investigation was enhanced by developing Build 3 of the TIMS network modeling and simulation model. The results of several 'what-if' scenarios are reported along with reports on upgraded antenna visibility determination software and unattended network management prototype.

  6. Flebotomíneos de Timóteo, Estado de Minas Gerais, Brasil (Diptera: Psychodidae Sand flies in Timóteo, Minas Gerais, Brazil (Diptera: Psychodidae

    Directory of Open Access Journals (Sweden)

    José Dilermando Andrade Filho

    1997-10-01

    Full Text Available Casos esporádicos de leishmaniose tegumentar têm ocorrido no Município de Timóteo, Minas Gerais, basicamente na população rural. Para conhecer a fauna de flebotomíneos da região, foram instaladas sete armadilhas luminosas de New Jersey na cidade, em sete diferentes bairros. As coletas foram realizadas no período de junho a outubro de 1994, dezembro de 1994 e janeiro a março de 1995, com um total de 3.240 horas por armadilha. Foram capturados 4.396 flebotomíneos, distribuídos em dois gêneros e vinte espécies: Brumptomyia cunhai, Brumptomyia nitzulescui, Lutzomyia (Nyssomyia whitmani, Lutzomyia (Nyssomyia intermedia, Lutzomyia quinquefer, Lutzomyia lenti, Lutzomyia (Pintomyia fischeri, Lutzomyia migonei, Lutzomyia sallesi, Lutzomyia termitophila, Lutzomyia aragaoi, Lutzomyia borgmeieri, Lutzomyia (Psathyromyia lutziana, Lutzomyia (Sciopemyia sordellii, Lutzomyia (Pintomyia pessoai, Lutzomyia (Trichopygomyia longispina, Lutzomyia misionensis, Lutzomyia (Psychodopygus davisi, Lutzomyia lanei, Lutzomyia (Pressatia sp. A espécie L. (N. whitmani foi a mais freqüente com 52,12%, seguida de L. (N. intermedia com 34,10%, e ambas podem estar participando da transmissão de leishmaniose cutânea na região.Sporadic cases of tegumentary leishmaniasis have occurred in Timóteo, Minas Gerais State, basically among the rural population. In order to study the region's sand fly population, New Jersey light traps were set in seven different neighborhoods. Specimens were gathered from June through October 1994, December 1994, and January through March 1995, with a total of 3,240 hours per trap. A total of 4,396 sand flies were captured, distributed among two genera and twenty species: Brumptomyia cunhai, Brumptomyia nitzulescui, Lutzomyia (Nyssomyia whitmani, Lutzomyia (Nyssomyia intermedia, Lutzomyia quinquefer, Lutzomyia lenti, Lutzomyia (Pintomyia fischeri, Lutzomyia migonei, Lutzomyia sallesi, Lutzomyia termitophila, Lutzomyia aragaoi, Lutzomyia

  7. Statins reduce the expressions of Tim-3 on NK cells and NKT cells in atherosclerosis.

    Science.gov (United States)

    Zhang, Na; Zhang, Min; Liu, Ru-Tao; Zhang, Peng; Yang, Chun-Lin; Yue, Long-Tao; Li, Heng; Li, Yong-Kang; Duan, Rui-Sheng

    2018-02-15

    3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have an immuno-regulatory effect in addition to lowing-lipids. Accumulated evidence showed that the expressions of T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) on natural killer (NK) cells increased in atherosclerotic patients and animal models. In this study, 14 patients treated with rosuvastatin and 12 patients with atorvastatin for more than 3 months were included and 20 patients without statins treatment as control. Both statins treatment reduced the expressions of Tim-3 on NK cells and their subtypes, natural killer T (NKT) cells and CD3 + T cells, and increased the proportions of NKT cells among peripheral blood mononuclear cells, accompanied by the decreased levels of total cholesterol, low density lipoprotein, and increased ratios of high density lipoprotein to cholesterol. These may contribute to the functions of statins in the treatment of atherosclerosis. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. TIMS-1: a processing code for production of group constants of heavy resonant nuclei

    International Nuclear Information System (INIS)

    Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

    1980-09-01

    The TIMS-1 code calculates the infinitely dilute group cross sections and the temperature dependent self-shielding factors for arbitrary values of σ 0 and R, where σ 0 is the effective background cross section of potential scattering and R the ratio of the atomic number densities for two resonant nuclei if any. This code is specifically programmed to use the evaluated nuclear data file of ENDF/B or JENDL as input data. In the unresolved resonance region, the resonance parameters and the level spacings are generated by using Monte Carlo method from the Porter-Thomas and Wigner distributions respectively. The Doppler broadened cross sections are calculated on the ultra-fine lethargy meshes of about 10 -3 -- 10 -5 using the generated and resolved resonance parameters. The effective group constants are calculated by solving the neutron slowing down equation with the use of the recurrence formula for the neutron slowing down source. The output of the calculated results is given in a format being consistent with the JAERI-Fast set (JFS) or the Standard Reactor Analysis Code (SRAC) library. Both FACOM 230/75 and M200 versions of TIMS-1 are available. (author)

  9. Minat Mahasiswa Setelah Lulus Kuliah Terhadap Entrepreneurs: Studi Kasus Mahasiswa Peserta Pelatihan Entrepreneurship Fakultas Agama Islam Universitas Darul ‘Ulum Jombang Tahun 2015

    Directory of Open Access Journals (Sweden)

    A. Syafi' AS

    2016-06-01

    Full Text Available Kewirausahaan (entrepreneurship adalah kemampuan kreatif dan inovatif dalam menciptakan nilai tambah di pasar melalui proses pengelolaan sumber daya dengan cara-cara baru dan berbeda. Di Indonesia, kewirausahaan dipelajari baru terbatas pada beberapa sekolah atau perguruan tinggi tertentu saja. Program yang dilakukan oleh Fakultas Agama Islam Universitas Darul ‘Ulum Jombang ditambah dengan adanya bantuan penguatan entrepreneurs centre PTKI tahun 2015 dari Direktorat Pendidikan Tinggi Islam Kementerian Agama RI dapat menjadi batu loncatan bagi mahasiswa Fakultas Agama Islam Universitas Darul ‘Ulum Jombang yang ingin membuka usaha pada saat lulus kuliah nanti. Penelitian ini merupakan SWOT analasis tentang minat mahasiswa peserta entrepreneursip mahasiswa Fakultas Agama Islam Universitas Darul ‘Ulum Jombang setelah lulus kuliah terhadap entrepreneurship. Teknik pengumpulan datanya melalui observasi, wawancara, angket dan dokumentasi. Berdasarkan hasil penelitian yang didapat adalah sebanyak 63.48% perempuan dan 66.05% laki-laki ingin membuka usaha setelah lulus, artinya minat menjadi wirausaha lebih besar pada mahasiswa laki-laki. Mahasiswa yang ingin bekerja setelah lulus adalah 24.17% perempuan dan 26.12% laki-laki. Untuk mahasiswa yang ingin menjadi Pegawai Negri Sipil setelah lulus hampir berimbang, yaitu 5.19% perempuan dan 5.23% laki-laki. Sedangkan yang menginginkan menjadi guru lebih banyak terjadi pada mahasiswa perempuan, yaitu 7.16% dan hanya 2.14% dari mahasiswa laki-laki. Yang paling menarik dalam temuan penelitian ini adalah didapatnya 0.46% mahasiswa laki-laki yang ingin menjadi ABRI pada saat lulus kuliah, melihat latar belakang data yang di dapat mahasiswa yang ingin jadi ABRI dilatarbelakangi oleh orangtuanya yang memang ABRI. || Entrepreneurship is the ability to be creative and innovative in creating added value in the market through the process of managing resources in new dan different ways. In Indonesia, a new study of

  10. Application of Circuit Simulation Method for Differential Modeling of TIM-2 Iron Uptake and Metabolism in Mouse Kidney Cells

    Directory of Open Access Journals (Sweden)

    Zhijian eXie

    2013-06-01

    Full Text Available Circuit simulation is a powerful methodology to generate differential mathematical models. Due to its highly accurate modelling capability, circuit simulation can be used to investigate interactions between the parts and processes of a cellular system. Circuit simulation has become a core technology for the field of electrical engineering, but its application in biology has not yet been fully realized. As a case study for evaluating the more advanced features of a circuit simulation tool called Advanced Design System (ADS, we collected and modeled laboratory data for iron metabolism in mouse kidney cells for a H ferritin (HFt receptor, T cell immunoglobulin and mucin domain-2 (TIM-2. The internal controlling parameters of TIM-2 associated iron metabolism were extracted and the ratios of iron movement among cellular compartments were quantified by ADS. The differential model processed by circuit simulation demonstrated a capability to identify variables and predict outcomes that could not be readily measured by in vitro experiments. For example, an initial rate of uptake of iron-loaded HFt was 2.17 pmol per million cells. TIM-2 binding probability with iron-loaded HFt was 16.6%. An average of 8.5 minutes was required for the complex of TIM-2 and iron-loaded HFt to form an endosome. The endosome containing HFt lasted roughly 2 hours. At the end of endocytosis, about 28% HFt remained intact and the rest was degraded. Iron released from degraded HFt was in the labile iron pool (LIP and stimulated the generation of endogenous HFt for new storage. Both experimental data and the model showed that TIM-2 was not involved in the process of iron export. The extracted internal controlling parameters successfully captured the complexity of TIM-2 pathway and the use of circuit simulation-based modeling across a wider range of cellular systems is the next step for validating the significance and utility of this method.

  11. Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim.

    Science.gov (United States)

    Zonato, Valeria; Vanin, Stefano; Costa, Rodolfo; Tauber, Eran; Kyriacou, Charalambos P

    2018-02-01

    The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may have originated in southeastern Italy. Flies characterized by the new allele show photoperiod-related phenotypes likely to be adaptive in seasonal environments. ls-tim may be spreading from its point of origin in Italy by directional selection, but there are alternative explanations for its observed clinal geographical distribution, including balancing selection and demography. From population analyses of ls-tim frequencies collected on the eastern side of the Iberian Peninsula, we show that ls-tim frequencies are inverted compared with those in Italy. This pattern is consistent with a scenario of directional selection rather than latitude-associated balancing selection. Neutrality tests further reveal the signature of directional selection at the ls-tim site, which is reduced a few kb pairs either side of ls-tim. A reanalysis of allele frequencies from a large number of microsatellite loci do not demonstrate any frequent ls-tim-like spatial patterns, so a general demographic effect or population expansion from southeastern Italy cannot readily explain current ls-tim frequencies. Finally, a revised estimate of the age of ls-tim allele using linkage disequilibrium and coalescent-based approaches reveals that it may be only 300 to 3000 years old, perhaps explaining why it has not yet gone to fixation. ls-tim thus provides a rare temporal snapshot of a new allele that has come under selection before it reaches equilibrium.

  12. A TIMS-based method for the high precision measurements of the three-isotope potassium composition of small samples

    DEFF Research Database (Denmark)

    Wielandt, Daniel Kim Peel; Bizzarro, Martin

    2011-01-01

    A novel thermal ionization mass spectrometry (TIMS) method for the three-isotope analysis of K has been developed, and ion chromatographic methods for the separation of K have been adapted for the processing of small samples. The precise measurement of K-isotopes is challenged by the presence of ...

  13. DIVERSITAS TIM MANAJEMEN PUNCAK, KEKOMPREHENSIFAN PENGAMBILAN KEPUTUSAN, INTEGRASI SOSIAL DAN KINERJA PERUSAHAAN: STUDI PADA BANK PERKREDITAN RAKYAT

    Directory of Open Access Journals (Sweden)

    Arief Prima Johan

    2014-07-01

    Full Text Available AbstractAlthough research on diversity management team had been widely conducted, previous research defined diversity in many different ways and many studies focused their research on top management team of big companies and big industries. This study examined the influence of several type of diversity of top management team on decision-making comprehensiveness and social integration, and tests these last two variables on performance. Using data Rural Banks (banking industry, the results showed that several variables of diversity of top management team affect decision-making comprehensiveness and social integration. The study also confirmed that the company's performance is affected by decision-making comprehensiveness and social integration.Keywords:Team Management, Diversity, Decision-Making Comprehensiveness, Social Integration, Performance.AbstrakMeskipun penelitian mengenai diversitas tim manajemen sudah banyak dilakukan, tetapi penelitian yang lalu mendefinisikan diversitas dengan cara yang berbeda-beda dan banyak berfokus pada tim manajemen puncak perusahaan besar dan industri besar. Penelitian ini menguji pengaruh variable-variabel diversitas tim manajemen puncak perusahaan terhadap kekomprehensifan pengambilan keputusan dan integrasi sosial, serta menguji dua variable terakhir ini pada kinerja. Dengan menggunakan data Bank Perkreditan Rakyat (industri perbankan, hasil penelitian memperlihatkan bahwa beberapa variable diversitas manajemen puncak mempengaruhi kekomprehensifan pengambilan keputusan dan integrasi sosial.Penelitian juga mengkonfirmasi bahwa kinerja perusahaan dipengaruhi oleh kekomprehensifan pengambilan keputusan dan integrasi sosial.Kata Kunci:Tim Manajemen Puncak, Diversitas, Kekomprehensifan, Pengambilan Keputusan, Integrasi Sosial, Kinerja Perusahaan.

  14. Thermal ionization mass spectrometry (TIMS) of actinides: Pushing the limits of accuracy and detection

    Energy Technology Data Exchange (ETDEWEB)

    Buerger, Stefan; Boulyga, Sergei; Cunningham, Alan; Klose, Dilani; Koepf, Andreas; Poths, Jane [Safeguards Analytical Laboratory, International Atomic Energy Agency, Vienna (Austria); Richter, Stephan [Institute for Reference Materials and Measurements, JRC-EU, Geel (Belgium)

    2010-07-01

    New method developments in multi-collector thermal ionization mass spectrometry (MC-TIMS) for actinide isotope ratio analysis to improve accuracy and limits of detection will be presented. With respect to limits of detection, results on improving work function using various carbon additives will be reviewed and presented as well as developments in cavity ion source (as compared to standard flat ribbon filament ion source) for femto- and attogram levels of uranium, plutonium, and americium. With respect to accuracy, results on isotope ratio measurements of isotopes of uranium (relative accuracy of 0.3% to 0.01%) are presented with an example being U-234-Th-230 age-dating (NBL CRM 112-A). In this context, the importance of traceability (to the S.I. units) and the use of (certified) reference materials are emphasized. The focus of this presentation is on applications to nuclear safeguards / forensics.

  15. El De imaginibus caelestibus de Ibn al-Ḥātim

    OpenAIRE

    Oliveras, Marc

    2009-01-01

    En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥāt...

  16. Towards unsupervised polyaromatic hydrocarbons structural assignment from SA-TIMS-FTMS data.

    Science.gov (United States)

    Benigni, Paolo; Marin, Rebecca; Fernandez-Lima, Francisco

    2015-10-01

    With the advent of high resolution ion mobility analyzers and their coupling to ultrahigh resolution mass spectrometers, there is a need to further develop a theoretical workflow capable of correlating experimental accurate mass and mobility measurements with tridimensional candidate structures. In the present work, a general workflow is described for unsupervised tridimensional structural assignment based on accurate mass measurements, mobility measurements, in silico 2D-3D structure generation, and theoretical mobility calculations. In particular, the potential of this workflow will be shown for the analysis of polyaromatic hydrocarbons from Coal Tar SRM 1597a using selected accumulation - trapped ion mobility spectrometry (SA-TIMS) coupled to Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). The proposed workflow can be adapted to different IMS scenarios, can utilize different collisional cross-section calculators and has the potential to include MS n and IMS n measurements for faster and more accurate tridimensional structural assignment.

  17. TIMS-1, Multigroup Cross-Sections of Heavy Isotope Mixture with Resonance from ENDF/B

    International Nuclear Information System (INIS)

    Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi

    1984-01-01

    1 - Description of problem or function: TIMS-1 is a code for calculating the group constants of heavy resonant nuclei by using ENDF/ B-4 format data. This code calculates infinitely dilute cross sections and self-shielding factors as a function of composition sigma-0 temperature T and R-parameter, where R is the ratio of ato- mic number density of two different resonant nuclei. 2 - Method of solution: In the unresolved resonance region, a ladder of resonance parameters and levels is generated with Monte Carlo method. The temperature dependent cross sections are calculated with the Breit-Wigner single-level and multi-level formula. The neutron spectrum is accurately calculated by solving numerically the neutron slowing down equation using a recurrence formula for neutron slowing down source. 3 - Restrictions on the complexity of the problem: The maximum numbers of energy groups, temperatures and compositions are 60, 4 and 10 respectively

  18. Sand flies in Timóteo, Minas Gerais, Brazil (Diptera: Psychodidae)

    OpenAIRE

    Andrade Filho, José Dilermando; Carneiro, Ana Paula Salgado; Lima, Mauro Lucio Nascimento; Santiago, Rodrigo Martins; Gama, Marco Antônio; Santos, Carlos Alberto; Falcão, Alda Lima; Brazil, Reginaldo Peçanha

    1997-01-01

    Casos esporádicos de leishmaniose tegumentar têm ocorrido no Município de Timóteo, Minas Gerais, basicamente na população rural. Para conhecer a fauna de flebotomíneos da região, foram instaladas sete armadilhas luminosas de New Jersey na cidade, em sete diferentes bairros. As coletas foram realizadas no período de junho a outubro de 1994, dezembro de 1994 e janeiro a março de 1995, com um total de 3.240 horas por armadilha. Foram capturados 4.396 flebotomíneos, distribuídos em dois gêneros e...

  19. SEM/TIMS analysis trials on hotswipe samples taken from a shielded cell at Harwell

    International Nuclear Information System (INIS)

    Tushingham, J.; Vatter, I.; Cooke, R.

    1998-09-01

    The IAEA require advanced techniques and procedures for the detection of traces of actinides to be applied to their environmental sampling programme for nuclear safeguards as a means to detect undeclared activities. 'Swipe' samples taken from within nuclear facilities by IAEA inspectors require analysis to determine their actinide content and composition by bulk and particle measurements. The use of analytical equipment capable of analysing individual particles, particularly of actinides, is essential to optimise the IAEA's aim to monitor Member State's nuclear activities more proficiently. A trial has been undertaken at the Harwell Laboratory of AEA Technology to establish the efficacy of scanning electron microscopy (SEM) and thermal ionisation mass spectrometry (TIMS) for the particle and bulk characterisation, respectively, of actinides on samples taken from within a shielded cell. These measurements were supported by γ-spectrometry and α-spectrometry. 'Hotswipe' samples taken from within a shielded cell with a well-known recent history have been prepared for particle and bulk analysis. SEM has been used to characterise individual particles from the swipe samples and the results have been related to known cell activities. Samples were prepared for SEM using a simple procedure to minimise the potential for sample contamination. The method proved to be capable of identifying 1 μm particles that contained U, Pu, Pa and Np. The measurement of U/Pu ratios was limited to particles that contained >2% Pu in U by weight. TIMS, together with alpha spectrometry, has been used to determine the bulk actinide composition of the samples whilst gamma spectrometry has been used to determine the fission product composition. Further work to improve the potential of SEM, and also secondary ionisation mass spectrometry (SIMS), for the measurement of hotswipe samples has been proposed. (author)

  20. Integrated Modeling System for Analysis of Watershed Water Balance: A Case Study in the Tims Branch Watershed, South Carolina

    Science.gov (United States)

    Setegn, S. G.; Mahmoudi, M.; Lawrence, A.; Duque, N.

    2015-12-01

    The Applied Research Center at Florida International University (ARC-FIU) is supporting the soil and groundwater remediation efforts of the U.S. Department of Energy (DOE) Savannah River Site (SRS) by developing a surface water model to simulate the hydrology and the fate and transport of contaminants and sediment in the Tims Branch watershed. Hydrological models are useful tool in water and land resource development and decision-making for watershed management. Moreover, simulation of hydrological processes improves understanding of the environmental dynamics and helps to manage and protect water resources and the environment. MIKE SHE, an advanced integrated modeling system is used to simulate the hydrological processes of the Tim Branch watershed with the objective of developing an integrated modeling system to improve understanding of the physical, chemical and biological processes within the Tims Branch watershed. MIKE SHE simulates water flow in the entire land based phase of the hydrological cycle from rainfall to river flow, via various flow processes such as, overland flow, infiltration, evapotranspiration, and groundwater flow. In this study a MIKE SHE model is developed and applied to the Tim branch watershed to study the watershed response to storm events and understand the water balance of the watershed under different climatic and catchment characteristics. The preliminary result of the integrated model indicated that variation in the depth of overland flow highly depend on the amount and distribution of rainfall in the watershed. The ultimate goal of this project is to couple the MIKE SHE and MIKE 11 models to integrate the hydrological component in the land phase of hydrological cycle and stream flow process. The coupled MIKE SHE/MIKE 11 model will further be integrated with an Ecolab module to represent a range of water quality, contaminant transport, and ecological processes with respect to the stream, surface water and groundwater in the Tims

  1. HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

    Directory of Open Access Journals (Sweden)

    Lishomwa C Ndhlovu

    2011-04-01

    Full Text Available The T cell immunoglobulin mucin 3 (Tim-3 receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurological complex and its classic neurological presentation called HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis, we investigated the expression of the Tim-3 receptor on CD8(+ T cells from a cohort of HTLV-1 seropositive asymptomatic and symptomatic patients. Patients diagnosed with HAM/TSP down-regulated Tim-3 expression on both CD8(+ and CD4(+ T cells compared to asymptomatic patients and HTLV-1 seronegative controls. HTLV-1 Tax-specific, HLA-A*02 restricted CD8(+ T cells among HAM/TSP individuals expressed markedly lower levels of Tim-3. We observed Tax expressing cells in both Tim-3(+ and Tim-3(- fractions. Taken together, these data indicate that there is a systematic downregulation of Tim-3 levels on T cells in HTLV-1 infection, sustaining a profoundly highly active population of potentially pathogenic T cells that may allow for the development of HTLV-1 complications.

  2. Upregulation of Tim-3 on CD4(+) T cells is associated with Th1/Th2 imbalance in patients with allergic asthma.

    Science.gov (United States)

    Tang, Fei; Wang, Fukun; An, Liyun; Wang, Xianling

    2015-01-01

    T cell Ig and mucin domain-containing molecule-3 (Tim-3) is a negative regulator preferentially expressed on Th1 cells. Allergic asthma is a clinical syndrome well characterized by Th1/Th2 imbalance. To investigate the role of Tim-3 in the pathogenesis of asthma and its relationship with Th1/Th2 imbalance, a total of 40 patients with allergic asthma and 40 healthy controls were enrolled. Expression of Tim-3 and Th1/Th2 imbalance as well as the relationship between them was analyzed by flow cytometry and real-time PCR. Peripheral blood mononuclear cells (PBMCs) were cultured in vitro and anti-Tim-3 was used to block Tim-3 signaling; Th1/Th2 cytokines in the culture supernatant were detected by enzyme linked immunosorbent assay (ELISA). CD4(+) T cells and B cells were sorted and co-cultured in vitro, and anti-Tim-3 was used to block Tim-3 signaling; Total IgG/IgE in the culture supernatant was detected by ELISA. The mRNA level of T-bet and IFN-γ were significantly decreased in allergic asthma patients, while GATA-3 and IL-4 were significantly increased. Expression of Tim-3 on CD4(+) T cells was much higher in allergic asthma patients and it was negatively correlated with T-bet/GATA-3 ratio or IFN-γ/IL-4 ratio. Blocking of Tim-3 significantly increased Th1 cytokines (TNF-α and IFN-γ) and decreased Th2 cytokines (IL-4, IL-5, IL-13) in the culture supernatant of PBMCs. Blocking of Tim-3 dramatically reduced the production of IgG and IgE in the co-culture supernatant of CD4(+) T cells and B cells. In conclusion, Tim-3 was up-regulated in allergic asthma patients and related with the Th1/Th2 imbalance. Blocking of Tim-3 may be of therapeutic benefit by enhancing the Th1 cytokines response, down-regulating the Th2 cytokines response, and reducing IgG/IgE production.

  3. Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry

    OpenAIRE

    Rhein, Bethany A.; Brouillette, Rachel B.; Schaack, Grace A.; Chiorini, John A.; Maury, Wendy

    2016-01-01

    Phosphatidylserine (PtdSer) receptors that are responsible for the clearance of dying cells have recently been found to mediate enveloped virus entry. Ebola virus (EBOV), a member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells. The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved PtdSer binding pocket within the amin...

  4. Interaction between Galectin-9/TIM-3 pathway and follicular helper CD4+ T cells contributes to viral persistence in chronic hepatitis C.

    Science.gov (United States)

    Zhuo, Ya; Zhang, Yi-Fu; Wu, Hong-Jie; Qin, Lei; Wang, Yan-Ping; Liu, A-Min; Wang, Xin-Hong

    2017-10-01

    Both Galectin 9 (Gal-9)/T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) pathway and follicular helper CD4 + T (Tfh) cells play important roles in persistent hepatitis C virus (HCV) infection. Thus, we aimed to investigate the regulatory role of interaction between Gal-9/TIM-3 pathway and Tfh cells in chronic hepatitis C. A total of 44 chronic hepatitis C patients and 19 normal controls (NCs) were enrolled in this study. Purified CD4 + T cells were cultured by TIM-3 Fc protein, recombinant Gal-9, or IL-21 for 48h. TIM-3 expression, Tfh proportion, and IL-21 production was measured, respectively. The immunomodulatory role of Gal-9/TIM-3 and IL-21 was also investigated in HCV cell culture system in vitro. We found that the percentage corresponding to both TIM-3-positive and CXCR5 + ICOS + Tfh cells within CD4 + T cells, which correlated with HCV RNA replication, was significantly elevated in patients with chronic hepatitis C in comparison with those in NCs. Moreover, blockade of Gal-9/TIM-3 pathway by TIM-3 Fc protein increased Tfh cells proportion, IL-21 mRNA and protein expression within purified CD4 + T cells, while activation of Gal-9/TIM-3 signaling by Gal-9 stimulation decreased IL-21 production in both patients with chronic HCV infection and healthy individuals. Meanwhile, high concentrations (100 and 200ng/mL) of IL-21 stimulation also elevated TIM-3 expression on CD4 + T cells in chronic hepatitis C. Furthermore, TIM-3 blockage and IL-21 stimulation suppressed mRNA expressions of HCV-induced antiviral proteins (myxovirus resistance A and oligoadenylate synthetase) in Huh7.5 cells without affecting viral replication in HCV cell culture system. The interaction between Gal-9/TIM-3 pathway and Tfh cells contributed to viral persistent in chronic HCV infection, which might be pivotal for development of new therapeutic approaches for chronic hepatitis C. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  5. MENGGAGAS PENDIDIKAN BERWAWASAN KEWIRAUSAHAAN DI PERGURUAN TINGGI ISLAM: STUDI KASUS FAKULTAS SYARI`AH DAN EKONOMI ISLAM IAIN “SMH” BANTEN 2014-2015

    Directory of Open Access Journals (Sweden)

    NUR HIDAYAH

    2016-03-01

    Abstrak. Menggagas Pendidikan Berwawasan Kewirausahaan Di Perguruan Tinggi Islam: Studi Kasus Fakultas Syari`Ah Dan Ekonomi Islam Iain “Smh” Banten 2014-2015. Penelitian ini berangkat dari keprihatinan terhadap tingginya tingkat pengangguran di kalangan para sarjana lulusan perguruan tinggi (Islam dan masih rendahnya proporsi pengusaha di Indonesia. Padahal tingginya proporsi pengusaha dapat menjadi salah satu indikator kemakmuran sebuah negara. Oleh karena itu timbul pertanyaan sejauh mana nilai-nilai Islam mendorong budaya wirausaha di kalangan umatnya? Dan bagaimana budaya wirausaha ditumbuh-kembangkan di lembaga pendidikan tinggi Islam? Penelitian ini bersifat deskriptif eskploratif dengan studi kasus pendidikan kewirausahaan di Fakultas Syari`ah dan Ekonomi Islam (FSEI IAIN “SMH” Banten. Hasil penelitian menunjukkan bahwa kurikulum prodi-prodi yang ada di FSEI belum sepenuhnya berwawasan kewirausahaan. Mahasiswa umumnya banyak dibekali dengan kompetensi dan ketrampilan yang mempersiapkan mereka sebagai sarjana ekonomi syari`ah yang akan mengisi profesi-profesi yang membutuhkan kompetensi di bidang ini seperti manajer, dosen, peneliti, dewan pengawas syariah, dan sebagainya, ketimbang profesi wirausahawan yang berkompetensi untuk merintis usaha dari bawah. Untuk membangun prodi kewirausahaan Islam/bisnis syari`ah di FSEI IAIN SMHB dibutuhkan political will yang kuat dari tidak hanya pihak kampus tetapi juga lembaga otoritas seperti Diktis Kemenag untuk memfasilitasi berdirinya prodi ini baik dari segi perizinan maupun pendanaan. Studi kelayakan awal yang lebih komprehensif perlu dilakukan untuk memetakan kebutuhan sarana dan prasarana seperti kebutuhan formasi dosen yang qualified di bidangnya, struktur kurikulum yang dapat membekali mahasiswa dengan berbagai karakter dan ketrampilan sebagai (calon pengusaha handal, dan sistem perekrutan untuk menjaring calon mahasiswa unggul. Mengingat profesi ini sangat berhubungan erat dengan sektor rill, perlu dibangun

  6. Coordinated Traffic Incident and Congestion Management (TIM-CM) : Mitigating Regional Impacts of Major Traffic Incidents in the Seattle I-5 Corridor

    Science.gov (United States)

    2018-02-02

    Within the Seattle metropolitan area, traffic incident management (TIM) operations provide a multi-jurisdictional and coordinated strategy to detect, respond to, and clear traffic incidents so that traffic flow can be restored quickly and safely. The...

  7. Feto-maternal immune regulation by TIM-3/galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy

    DEFF Research Database (Denmark)

    Meggyes, Matyas; Lajko, Adrienn; Palkovics, Tamas

    2015-01-01

    INTRODUCTION: Immunoregulation implies the activation of negative pathways leading to the modulation of specific immune responses. Co-inhibitory receptors (such as PD-1 and TIM-3) represent possible tools for this purpose. PD-1 and TIM-3 have been demonstrated to be present on immune cells...... suggesting general involvement in immunosuppression such as fetomaternal tolerance. The aim of our study was to investigate the expression pattern of PD-1, TIM-3, and its ligand Gal-9 on different immune cell subsets in the peripheral blood and at the fetomaternal interface in pregnant mice. METHODS: TIM-3...... and PD-1 expression by peripheral and decidual immune cells from pregnant BALB-c mice in 2 weeks of gestational age were measures by flow cytometry. Placental galectin-9 expression was determined by immunohistochemically and RT-PCR. RESULTS: Gal-9 was found to be present in the spongiotrophoblast layer...

  8. Determination of isotopic composition of boron in boron carbide by TIMS and PIGE: an inter-comparison study

    International Nuclear Information System (INIS)

    Sasibhushan, K.; Rao, R.M.; Parab, A.R.; Alamelu, D.; Aggarwal, S.K.; Acharya, R.; Chhillar, S.; Pujari, P.K.

    2015-01-01

    The paper reports a comparison of results on the determination of isotopic composition of boron in boron carbide (B 4 C) samples by Thermal Ionisation Mass Spectrometry (TIMS) and Particle Induced Gamma ray Spectrometry (PIGE). B 4 C samples having varying boron isotopic composition (natural, enriched with respect to 10 B) and their synthetic mixtures) have been analysed by both the techniques. The 10 B atom% was found to be in the range of 20-67%. (author)

  9. The Fiction of Tim Winton: Relational Ecology in an Unsettled Land

    Directory of Open Access Journals (Sweden)

    Lyn McCredden

    2017-11-01

    Full Text Available Complicating the processes of belonging in place, for non-Indigenous Australians, is the growing realization that they live in a huge, diverse land, a place in which they are not native. The fiction of popular Anglo-Saxon Australian novelist Tim Winton echoes the understanding of poet Judith Wright, for whom “two strands – the love of the land we have invaded and the guilt of the invasion – have become part of me. It is a haunted country” (Wright 1991: 30. This essay will explore Winton’s novels in which there is a pervasive sense of unease and loss experienced by the central characters, in relation to place and land. Winton’s characters – Queenie Cookson and her traumatic witnessing of the barbaric capture and flaying of whales; Fish Lamb’s near-drowning in the sea, and Lu Fox’s quest for refuge in the wilderness, prophet-like, after the tragedy of his family’s death – are all written with a haunting sense of white unsettlement and displacement, where such natural forces – the sea and its creatures, the land’s distances and risks – confront and re-form the would-be dominators.

  10. The many Metaphysics within Physics. Essay review of 'The Metaphysics within Physics' by Tim Maudlin

    Science.gov (United States)

    Suárez, Mauricio

    Tim Maudlin's new book The Metaphysics within Physics (Oxford University Press, 2007) collects six essays by one of the most thoughtful and original minds working in the philosophy of physics nowadays. Some had previously circulated informally for years. For example, Chapter 1 ('A Modest Proposal Concerning Laws, Counterfactuals and Explanations') is as old as my own philosophical career-I recall reading a draft in the early 1990s. The mere publication of such a long-awaited collection is therefore already good news. In addition, the degree of coherence and the lack of redundancy are greater than one would expect from a collection of disparate essays written at diverse times and with a range of different targets. The whole book can be understood coherently as an extended argument in favor of a particular 'physics-based' methodology for inquiry in metaphysics. This methodology recommends a detailed and thorough analysis of current physics as a benchmark for any thesis, dispute or argument in metaphysics. It follows that proper metaphysical inquiry must be suitably informed not just about the current state of play in analytical metaphysics but also about the current state of development of the relevant part of present day physics.

  11. The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

    Directory of Open Access Journals (Sweden)

    Isabel Gonçalves Silva

    2017-08-01

    Full Text Available Acute myeloid leukemia (AML is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which includes ligand-dependent activation of ectopically expressed latrophilin 1 and possibly other G-protein coupled receptors leading to increased translation and exocytosis of the immune receptor Tim-3 and its ligand galectin-9. This occurs in a protein kinase C and mTOR (mammalian target of rapamycin-dependent manner. Tim-3 participates in galectin-9 secretion and is also released in a free soluble form. Galectin-9 impairs the anti-cancer activity of cytotoxic lymphoid cells including natural killer (NK cells. Soluble Tim-3 prevents secretion of interleukin-2 (IL-2 required for the activation of cytotoxic lymphoid cells. These results were validated in ex vivo experiments using primary samples from AML patients. This pathway provides reliable targets for both highly specific diagnosis and immune therapy of AML.

  12. α-Lactose Improves the Survival of Septic Mice by Blockade of TIM-3 Signaling to Prevent NKT Cell Apoptosis and Attenuate Cytokine Storm.

    Science.gov (United States)

    Yao, Yao; Deng, Hai; Li, Pingfei; Zhang, Jian; Zhang, Junbo; Wang, Deping; Li, Songbo; Luo, Yixing; Wei, Zhengping; Bi, Guoyu; Yang, Xiang-Ping; Tang, Zhao-Hui

    2017-03-01

    Sepsis is the leading cause of death among critically ill patients and natural killer T (NKT) cell activation is essential to induce inflammatory cytokine cascade in sepsis. However, little is known about what regulates the NKT cell function during sepsis. Herein, we showed that T-cell immunoglobulin and mucin domain 3 (Tim-3) expression in NKT cells is elevated in experimental mice during sepsis. Tim-3 expression was positively correlated with NKT cell activation and apoptosis. In sepsis, interleukin (IL)-12 secreted by dendritic cell exposure to lipopolysaccharide increased the expression of Tim-3 in NKT cells. Administration of α-lactose to block Tim-3 signaling pathway significantly improved the survival of septic mice, concomitant with reduced IL-12 production by dendritic cells, reduced Tim-3 expression, prevented NKT cell apoptosis, and attenuated production of inflammatory cytokines. Collectively, Tim-3 signaling in NKT cells plays a critical role in the immunopathogenesis of sepsis. Thus, α-lactose could be a promising immunomodulatory agent in the treatment of sepsis.

  13. Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant.

    Directory of Open Access Journals (Sweden)

    Kerry L Hilligan

    Full Text Available Macrophage and dendritic cell (DC populations residing in the intestinal lamina propria (LP are highly heterogeneous and have disparate yet collaborative roles in the promotion of adaptive immune responses towards intestinal antigen. Under steady-state conditions, macrophages are efficient at acquiring antigen but are non-migratory. In comparison, intestinal DC are inefficient at antigen uptake but migrate to the mesenteric lymph nodes (mLN where they present antigen to T cells. Whether such distinction in the roles of DC and macrophages in the uptake and transport of antigen is maintained under immunostimulatory conditions is less clear. Here we show that the scavenger and phosphatidylserine receptor T cell Immunoglobulin and Mucin (TIM-4 is expressed by the majority of LP macrophages at steady-state, whereas DC are TIM-4 negative. Oral treatment with the mucosal adjuvant cholera toxin (CT induces expression of TIM-4 on a proportion of CD103+ CD11b+ DC in the LP. TIM-4+ DC selectively express high levels of co-stimulatory molecules after CT treatment and are detected in the mLN a short time after appearing in the LP. Importantly, intestinal macrophages and DC expressing TIM-4 are more efficient than their TIM-4 negative counterparts at taking up apoptotic cells and soluble antigen ex vivo. Taken together, our results show that CT induces phenotypic changes to migratory intestinal DC that may impact their ability to take up local antigens and in turn promote the priming of mucosal immunity.

  14. Investigation of T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) polymorphisms in essential thrombocythaemia (ET).

    Science.gov (United States)

    Han, Fuyan; Wang, Guanghai; Li, Yuantang; Tian, Wenjun; Dong, Zhenfang; Cheng, Shiqing; Liu, Yiqing; Qu, Teng; Wang, Xiaoying; Wang, Yong; Zhang, Bingchang; Ju, Ying

    2017-07-01

    T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) is preferentially expressed on terminally differentiated Th1 cells and inhibits their IFN-γ production. It has been reported that chronic inflammation may be an important driving force for myeloproliferative neoplasms (MPNs). Therefore, we hypothesized that as an important inflammation regulator, TIM-3 may be involved in essential thrombocythaemia (ET). The goal of this study was to investigate whether the -1516G > T, -574G > T and +4259T > G single-nucleotide polymorphisms (SNPs) within the TIM-3 gene contribute to the genetic susceptibility of individuals to ET. Genotyping of the TIM-3 -1516G > T, -574G > T and + 4259T > G SNPs was performed in 175 patients with ET and in 151 controls via a polymerase chain reaction-restriction fragment length polymorphism assay. We also investigated the relationships between the genotypes of each SNP and the risk factors of ET such as routine blood indexes, age and JAK2 V617F mutation. The genotype and allele frequencies of the -1516G > T SNP (p = 0.016 and 0.019, respectively), the -574G > T SNP (p = 0.035 and 0.038, respectively) and the +4259T > G SNP (p = 0.036 and 0.038, respectively) of the ET patients and the controls were significantly different. A haplotype analysis found that the GGT and TGT haplotypes had significantly different distributions between ET and controls (p = 0.041 and 0.041, respectively). However, no significant differences were detected between the genotypes of all SNPs and routine blood indexes, age and JAK2V617F mutation. The -1516G > T, -574G > T and +4259T > G SNPs within TIM-3 gene might play an important role as a genetic risk factor in the pathogenesis of ET.

  15. Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway

    Science.gov (United States)

    Cao, Wei; Ryan, Michelle; Buckley, Deirdre; O'Connor, Rosemary; Clarkson, Michael R

    2011-01-01

    Emerging experimental data suggest an important role for the T-cell immunoglobulin mucin 1 (Tim-1):Tim-4 pathway in autoimmune and alloimmune responses in vivo. Using a Tim-4 ectodomain human IgG Fc fusion protein we studied the role of Tim-4 in T-cell activation, signalling and differentiation responses in vitro. We demonstrate that Tim-4Fc can inhibit naive and pre-activated T-cell activation, proliferation and cytokine secretion via a Tim-1-independent pathway. Tim-4 contains immunoglobulin variable (IgV) and mucin domains; to identify which domain accounts for the inhibitory effect novel Tim-4 fusion proteins containing either the IgV or mucin domain were generated. We demonstrate that both IgV and mucin domains are required for the inhibitory effects and that they are mediated at least in part by inhibition of extracellular signal-regulated kinase pathway activity. Given the emerging interest in the role of the Tim family in T helper type 17 (Th17) cells, which play an important role in autoimmune disease and transplantation tolerance, our data show that Tim-4Fc can prevent polarization of CD4+ T cells to the Th17 phenotype. Collectively, our results highlight an inhibitory role for Tim-4Fc in vitro, which we propose is mediated by a receptor other than Tim-1. In addition, this study provides new insights into the role of Tim-4Fc in regulating Th17 immune responses and may open a new avenue for autoimmune therapy. PMID:21463297

  16. Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway.

    LENUS (Irish Health Repository)

    Cao, Wei

    2011-06-01

    Emerging experimental data suggest an important role for the T-cell immunoglobulin mucin 1 (Tim-1):Tim-4 pathway in autoimmune and alloimmune responses in vivo. Using a Tim-4 ectodomain human IgG Fc fusion protein we studied the role of Tim-4 in T-cell activation, signalling and differentiation responses in vitro. We demonstrate that Tim-4Fc can inhibit naive and pre-activated T-cell activation, proliferation and cytokine secretion via a Tim-1-independent pathway. Tim-4 contains immunoglobulin variable (IgV) and mucin domains; to identify which domain accounts for the inhibitory effect novel Tim-4 fusion proteins containing either the IgV or mucin domain were generated. We demonstrate that both IgV and mucin domains are required for the inhibitory effects and that they are mediated at least in part by inhibition of extracellular signal-regulated kinase pathway activity. Given the emerging interest in the role of the Tim family in T helper type 17 (Th17) cells, which play an important role in autoimmune disease and transplantation tolerance, our data show that Tim-4Fc can prevent polarization of CD4(+) T cells to the Th17 phenotype. Collectively, our results highlight an inhibitory role for Tim-4Fc in vitro, which we propose is mediated by a receptor other than Tim-1. In addition, this study provides new insights into the role of Tim-4Fc in regulating Th17 immune responses and may open a new avenue for autoimmune therapy.

  17. Magmatic Longevity Constrained by ID-TIMS U-Pb Dating of Zircon and Titanite

    Science.gov (United States)

    Szymanowski, D.; Wotzlaw, J. F.; Ellis, B. S.; Bachmann, O.; Von Quadt, A.

    2016-12-01

    Clues about the timescales and thermal conditions associated with the growth and evacuation of large silicic magma reservoirs are frequently drawn from radiometric dating, diffusion modelling, or thermomechanical modelling. A growing amount of petrological and geochronological evidence, supported by thermal modelling, suggests that many silicic magma reservoirs may exist for some 104-106 years in the form of high-crystallinity mushes at relatively low temperatures ( 700-750°C; [1-3]). Geochronological studies addressing this issue typically utilise the U-Pb system in zircon capable of recording extended periods of crystallisation, particularly in evolved calc-alkaline systems that spend most of their lifetime zircon-saturated. In this study, we integrate U-Pb dating of zircon and titanite to investigate the longevity of the magma reservoir that produced the Kneeling Nun Tuff, a 35 Ma, >900 km3 crystal-rich rhyolitic super-eruption from the Mogollon-Datil volcanic field in New Mexico (USA). High-precision ID-TIMS U-Pb dates of single crystals of both zircon and titanite independently record a continuous crystallisation history over >400,000 years. We combine the dating of both accessory phases with textural, major, trace element and isotopic studies of single crystals, placing tight constraints on the thermal conditions of magma accumulation and storage while recording differentiation and rejuvenation processes within the magma reservoir. The results suggest a protracted `cool' upper-crustal storage of magma prior to the Kneeling Nun Tuff eruption followed by a melting event which reduced the magma crystallinity and conditioned it for eruption. [1] Bachmann & Bergantz (2004), J. Petrol. 45, 1565-1582. [2] Gelman et al. (2013), Geology 41, 759-762. [3] Cooper & Kent (2014), Nature 506, 480-483.

  18. Blocking Tim-3 or/and PD-1 reverses dysfunction of tumor-infiltrating lymphocytes in HBV-related hepatocellular carcinoma.

    Science.gov (United States)

    Liu, Furong; Zeng, Gucheng; Zhou, Shaotang; He, Xiaoshun; Sun, Nianfeng; Zhu, Xiaofeng; Hu, Anbin

    2018-03-22

    The immunosuppression of tumor-infiltrating lymphocytes (TILs) is associated with rapid progression of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). T cell Ig- and mucin-domain-containing molecule-3 (Tim-3) and programmed cell death 1 (PD-1) are important inhibitory molecules expressed on the surface of T cells, but their roles in the function of TILs in HBV-HCC are poorly understood. We aimed to study the roles of these two markers in HBV-HCC. Ninety patients with pathologically confirmed HBV-associated HCC were enrolled in our study. Blood samples, paired fresh tumor tissues and adjacent tissues were collected, and isolating peripheral blood mononuclear cells, TILs and adjacent-infiltrating lymphocytes were isolated from these samples. The patients were followed-up to allow survival analysis. Tim-3 or/and PD-1 was up-regulated expressed on CD4 + and CD8 + TILs in HBV-HCC patients and a higher proportion of TILs expressed PD-1 alone. Tim-3 + and PD-1 + TILs greatly decreased secretion of IFN-γ and TNF-α. Expression of Tim-3 and PD-1 on TILs negatively correlated with disease-free survival of HCC patients. Direct blockade of Tim-3 and PD-1 in vitro significantly enhanced TILs proliferation and secretion of IFN-γ and TNF-α. Expression of Tim-3 and/or PD-1 on TILs impairs their function and correlates negatively with disease-free survival in HBV-HCC. Direct blockade of Tim-3 and PD-1 restores anti-tumor effects of TILs, which suggests a potential target for novel immunotherapy in HBV-HCC. Copyright © 2018 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  19. Pemahaman terhadap Konsep Pahala dan Dosa Serta Hubungannya Dengan Etos Kerja Dosen dan Pegawai Fakultas Ushuluddin dan Pemikiran Islam IAIN Raden Fatah Palembang

    Directory of Open Access Journals (Sweden)

    Idrus Alkaf

    2016-03-01

    Full Text Available Artikel ini membahas tentang konsep pahala dan dosa dalam ajaran Islam dan pengaruhnya terhadap etos kerja dosen dan staf Fakultas Ushuluddin dan Pemikiran Islam, IAIN Raden Fatah Palembang. Pemahaman tentang pahala dan dosa, yang merupakan bagian dari doktrin etika dalam Islam ternyata memiliki peran dalam menentukan etos kerja. Kegiatan yang dianggap baik berdasarkan ajaran Islam pasti akan dihargai. Sebaliknya, mereka yang tidak menjalankan atau yang melanggar aturan akan mendapatkan dosa sebagai balasannya. Dengan menggunakan metode pengumpulan data melalui survei, observasi, wawancara atau kuesioner, dalam artikel ini, diketahui bahwa pemahaman dosen dan staf tentang pahala dan dosa ternyata sangat berhubungan dengan etos kerja mereka sehari-hari. Semakin baik tingkat pemahaman dosen dan staf dengan konsep pahala dan dosa, semakin tinggi etos kerja mereka. Ini menyiratkan bahwa pemahaman seseorang tentang konsep pahala dan dosa itu dapat mendorong orang untuk bekerja lebih baik, lebih serius dan lebih berhati-hati. Atau dengan kata lain, secara teologis pemahaman ini dapat berdampak pada aktivitas sehari-hari. This article discusses the concept of merit and sin in Islam and the influence by the work ethic of faculty and staff of the Faculty of Islamic Theology and Islamic Thought, Islamic State Institute Raden Fatah Palembang. Understanding of merit and sin, which is part of the doctrine of ethics in Islam to have a role in determining the work ethic. Activities that are considered good based on the teachings of Islam is believed to be rewarded. Vice versa, those who do not run or that violate the rules will get sin as a reward. By Idrus analysis using the method of data collection through the courts (survey, observation, interviews or questionnaires, in this article, Idrus found understanding of faculty and staff to the concept of merit and sin is very in touch with their work ethic in everyday tasks. Or the better the level of

  20. CB2 cannabinoid receptors modulate HIF-1α and TIM-3 expression in a hypoxia-ischemia mouse model.

    Science.gov (United States)

    Kossatz, Elk; Maldonado, Rafael; Robledo, Patricia

    2016-12-01

    The role of CB2 cannabinoid receptors (CB 2 R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB 2 R in the behavioural and biochemical underpinnings related to brain damage induced by HI in adult mice, and the mechanisms involved. CB 2 R knockout (KO) mice and wild-type littermates (WT) underwent permanent ligation of the left common carotid artery and hypoxia. Behavioural measurements in the rotarod, beam walking, object recognition, open field, and Irwin tests were carried out 24h, 72h and 7 days. In KO mice, more extensive brain injury was observed. Behavioural deficits in the Irwin test were observed in both genotypes; while WT mice showed progressive recovery by day 7, KO mice did not. Only KO mice showed alterations in motor learning, coordination and balance, and did not recover over time. A higher expression of microglia and astrocytes was observed in several brain areas of lesioned WT and KO mice. The possible alteration of the inflammatory-related factors HIF-1α and TIM-3 was evaluated in these animals. In both genotypes, HIF-1α and TIM-3 expression was observed in lesioned areas associated with activated microglia. However, the expression levels of these proteins were exacerbated in KO mice in several lesioned and non-lesioned brain structures. Our results indicate that CB 2 R may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1α/TIM-3 signalling pathway in microglia. Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

  1. High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals.

    Directory of Open Access Journals (Sweden)

    Stefan Ryser

    Full Text Available We report here the cloning of native high affinity anti-TIM-3 and anti-KIR IgG monoclonal antibodies (mAbs from peripheral blood mononuclear cells (PBMC of healthy human donors. The cells that express these mAbs are rare, present at a frequency of less than one per 105 memory B-cells. Using our proprietary multiplexed screening and cloning technology CellSpot™ we assessed the presence of memory B-cells reactive to foreign and endogenous disease-associated antigens within the same individual. When comparing the frequencies of antigen-specific memory B-cells analyzed in over 20 screening campaigns, we found a strong correlation of the presence of anti-TIM-3 memory B-cells with memory B-cells expressing mAbs against three disease-associated antigens: (i bacterial DNABII proteins that are a marker for Gram negative and Gram positive bacterial infections, (ii hemagglutinin (HA of influenza virus and (iii the extracellular domain of anaplastic lymphoma kinase (ALK. One of the native anti-KIR mAbs has similar characteristics as lirilumab, an anti-KIR mAb derived from immunization of humanized transgenic mice that is in ongoing clinical trials. It is interesting to speculate that these native anti-TIM-3 and anti-KIR antibodies may function as natural regulatory antibodies, analogous to the pharmacological use in cancer treatment of engineered antibodies against the same targets. Further characterization studies are needed to define the mechanisms through which these native antibodies may function in healthy and disease conditions.

  2. On the Use of 233U-236U Double-Spike for TIMS Measurements of Uranium Isotopes: A Simulation Study

    International Nuclear Information System (INIS)

    Williams, R W

    2004-01-01

    Synthetic ion beams with instantaneous and temporal characteristics appropriate to thermal ionization mass spectrometry (TIMS) were mathematically generated and analyzed to determine the effects of using a mixed 233 U- 236 U spike (double-spike) in the analysis of uranium isotopes. The instantaneous beam characteristics are the intensities (e.g., counts per second) modeled with a Poisson distribution plus a component of random noise that simulates the detection processes. Several beam intensity and mass fractionation vs. time functions were modeled to simulate a range of sample sizes and the commonly employed methods of data collection. These beam profiles were also generated with different noise levels, and signal-to-noise vs. analytical precision diagrams are presented. Modeling focused on natural uranium, where 238 U/ 235 U = 137.88, and on the ability of a given method to determine precisely and accurately small variations in this ratio. Practical limits on precision were determined to be 20-30 ppm, which is consistent with precision seen for other elements by state-of-the-art TIMS. The TIMS total evaporation method was compared directly with the double-spike method. While similar analytical precisions are obtained with either method, the double-spike method of correcting for analytical bias gives more accurate results. The results of a total evaporation analysis will deviate from true by more than the analytical precision if as little as 0.05% of the signal is not integrated, whereas the accuracy and precision of the double-spiked analyses are always linked

  3. The particle analysis based on FT-TIMS technique for swipe sample under the frame of nuclear safeguard

    International Nuclear Information System (INIS)

    Yang Tianli; Liu Xuemei; Liu Zhao; Tang Lei; Long Kaiming

    2008-06-01

    Under the frame of nuclear safeguard, the particles analysis for swipe sample is an advance mean to detect the undeclared uranium enriched facilities and undeclared uranium enriched activity. The technique of particle analysis based on fission track-thermal ionization mass spectrometry (FT-TIMS) for swipe sample have been built. The reliability and the experimental background for selecting particles consisting of uranium from swipe sample by FT method have been verified. In addition, the utilization coefficient of particles on the surface of swipe sample have also been tested. These works have provided the technique support for application in the area of nuclear verification. (authors)

  4. High-precision ID-TIMS zircon U-Pb geochronology using new 1013 Ohm resistors

    Science.gov (United States)

    Von Quadt, A.; Buret, Y.; Large, S.; Peytcheva, I.; Trinquier, A.; Wotzlaw, J. F.

    2015-12-01

    Faraday cups equipped with high gain amplifiers provide a means to measure small ion beams in static mode without the limited linear range of ion counting systems. We tested the application of newly available 1013 Ohm resistors to ID-TIMS zircon U-Pb geochronology using a range of natural and synthetic reference materials. The TritonPlus-RPQ at the Institute of Geochemistry and Petrology, ETH Zurich, is equipped with five new 1013 Ohm resistors and one MasCom secondary electron multiplier, allowing to measure the 202-204-205-206-207-208Pb masses in static mode. U is measured subsequently as U-oxide (265-267-270UO2) during a second step, also in static Faraday mode. The gain calibration of the 1013 Ohm resistors was performed using the procedure of Trinquier (2014), with 144Nd-146Nd being measured using 1011 Ohm resistor and 142-143-145-148-150Nd being measured using 1013 Ohm resitors (Trinquier, 2014; Koornneef et al., 2014). Standard deviations of the noise in all five new 1013 Ohm resistors are lower than 5.0 x 10-6 over a 6 month period, with no shift occurring over this time interval. This new detector set-up was tested by analyzing natural zircon standard materials and synthetic U/Pb solutions (www.earthime.org), ranging in age from ~2 Ma to ~600 Ma. All natural zircon standards were chemically abraded (Mattinson, 2005) and all samples were spiked with the ET2535 tracer solution. U-Pb dates obtained using the static measurement routine are compared to measurements employing dynamic peak jumping routines on the MasCom multiplier. This study illustrates the benefits and current limitations of using high gain amplifiers to measure small ion beams for zircon U-Pb geochronology compared to conventional dynamic ion counting techniques. Mattinson, J.M. (2005) Chemical Geology 220:47-66; Trinquier, A. (2014) Application Note 30281; Koornneef, J. et al (2014) Analytica Chimica Acta 819:49-55.

  5. Mini-DIAL system measurements coupled with multivariate data analysis to identify TIC and TIM simulants: preliminary absorption database analysis

    International Nuclear Information System (INIS)

    Gaudio, P; Malizia, A; Gelfusa, M; Poggi, L.A.; Martinelli, E.; Di Natale, C.; Bellecci, C.

    2017-01-01

    Nowadays Toxic Industrial Components (TICs) and Toxic Industrial Materials (TIMs) are one of the most dangerous and diffuse vehicle of contamination in urban and industrial areas. The academic world together with the industrial and military one are working on innovative solutions to monitor the diffusion in atmosphere of such pollutants. In this phase the most common commercial sensors are based on “point detection” technology but it is clear that such instruments cannot satisfy the needs of the smart cities. The new challenge is developing stand-off systems to continuously monitor the atmosphere. Quantum Electronics and Plasma Physics (QEP) research group has a long experience in laser system development and has built two demonstrators based on DIAL (Differential Absorption of Light) technology could be able to identify chemical agents in atmosphere. In this work the authors will present one of those DIAL system, the miniaturized one, together with the preliminary results of an experimental campaign conducted on TICs and TIMs simulants in cell with aim of use the absorption database for the further atmospheric an analysis using the same DIAL system. The experimental results are analysed with standard multivariate data analysis technique as Principal Component Analysis (PCA) to develop a classification model aimed at identifying organic chemical compound in atmosphere. The preliminary results of absorption coefficients of some chemical compound are shown together pre PCA analysis. (paper)

  6. Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression.

    Science.gov (United States)

    Dong, Jianfeng; Cheng, Lijun; Zhao, Minchao; Pan, Xiangfeng; Feng, Zhiqiang; Wang, Dawei

    2017-05-01

    Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development. Strong antitumor immune responses, especially CD8 + T cell responses, are thought to be essential to effective cancer treatment and are associated with better prognosis in oropharyngeal head and neck squamous cell carcinoma. In this study, we examined the role of the Tim-3/Gal-9 pathway in oropharyngeal head and neck squamous cell carcinoma patients. We found that Gal-9 expression by CD4 + T cells was increased in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients, but not in human papillomavirus-negative oropharyngeal head and neck squamous cell carcinoma patients. Increased Gal-9 secretion by CD4 + T cells presented multiple immunosuppressive effects. Coculturing monocytes with high Gal-9-expressing CD4 + T cells resulted in the expansion of Tim-3 + monocytes, which suppressed interferon gamma production by activated CD8 + T cells. Subsequently, total monocytes incubated with exogenous Gal-9, or high Gal-9-expressing CD4 + T cells, suppressed the expression of interferon gamma by CD8 + T cells. Exogenous Gal-9 and high Gal-9-expressing CD4 + T cells also suppressed the secretion of both interleukin 10 and interleukin 12 by monocytes. These effects are Tim-3/Gal-9-dependent because blocking Tim-3 and/or Gal-9 could enhance the support of CD8 + T cell interferon gamma production and the interleukin 10 and interleukin 12 secretion by monocytes. Together, these data suggest that the high Tim-3 expression in monocytes could be utilized by tumor-promoting Gal-9 expression on CD4 + T cells. Immunotherapy in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients therefore faces an additional challenge posed by Tim-3 and Gal-9 and likely requires the blockade of these

  7. Comparison of Nitrogen Bioaccessibility from Salmon and Whey Protein Hydrolysates using a Human Gastrointestinal Model (TIM-1

    Directory of Open Access Journals (Sweden)

    Bomi Framroze

    2014-05-01

    Full Text Available Background: The TIM-1 system is a computer-controlled multi-compartmental dynamic model that closely simulates in vivo gastrointestinal tract digestion in humans. During digestion, the compounds released from meal matrix by gastric and intestinal secretions (enzymes are progressively absorbed through semipermeable membranes depending on their molecular weight. These absorbed (dialysed compounds are considered as bioaccessible, which means that they can be theoretically absorbed by the small intestine in the body. Methods: Salmon protein hydrolysate (SPH, whey protein hydrolysates extensively (WPHHigh or weakly (WPH-Low hydrolysed, non-hydrolysed whey protein isolate (WPI and mixtures of WPI:SPH (90:10, 80:20 were digested in TIM-1 using the conditions for a fast gastrointestinal transit that simulate the digestion of a liquid meal in human adults. During digestion (2 hours, samples were collected in intestinal compartments (duodenum, jejunum, and ileum and in both jejunal and ileal dialysates to determine their nitrogen content. All the products were compared in terms of kinetics of nitrogen absorption through the semipermeable membranes (bioaccessible nitrogen and nitrogen distribution throughout the intestinal compartments at the end of the 2 hour digestion. Results: After a 2 h-digestion in TIM-1, SPH was the protein substrate from which the highest amount of nitrogen (67.0% becomes available for the small intestine absorption. WPH-High had the second highest amount (56.0% of bioaccessible nitrogen while this amount decreased to 38.5–42.2% for the other protein substrates. The high nitrogen bioaccessibility of SPH is consistent with its richness in low molecular weight peptides (50% < 1000 Da. Conclusions: The results of this study indicate that SPH provides a higher proportion of bioaccessible nitrogen to a healthy adult compared to all forms of whey proteins, including extensively hydrolysed whey protein hydrolysate. The substitution of

  8. Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer.

    Science.gov (United States)

    Gao, Jianwei; Qiu, Xiangyu; Li, Xinying; Fan, Hang; Zhang, Fang; Lv, Tangfeng; Song, Yong

    2018-04-06

    Exosomes are membrane-bound, virus-sized vesicles present in circulating blood. Tumor cells are avid producers of exosomes, which are thought to mimic molecular features of parent tumor cells. T-cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) is a the next-generation immune checkpoint that can be activated by its ligand Galectin-9 to negatively regulate the anti-tumor immune response. However, the characteristics of plasma exosomal Tim-3 and Galectin-9 (Exo-T/G) in cancer remained unknown. This study was conducted to investigate the expression patterns and clinical value of plasma exosomal total protein (Exo-pro) and Exo-T/G in non-small cell lung cancer (NSCLC). Plasma was collected from 103 NSCLC patients including 60 early stages and 43 advanced stages disease samples as well as 56 healthy subjects. Exosomes were isolated from plasma by commercial exosome precipitation solution and identified by western blotting of CD63 and transmission electron microscopy. Exo-pro concentration was measured by the BCA assay. Enzyme-linked immunosorbent assay was used to quantify Exo-T/G. Additionally, 34 NSCLC samples were applied to directly detect plasma TIM-3 (Plas-T) and Galectin-9 (Plas-G). Our results showed that Exo-pro, Exo-T, and Exo-G were significantly increased in NSCLC plasma compared to that in the healthy samples. High levels of Exo-T and Exo-G were all positively correlated with several malignant parameters, including larger tumor size, advanced stages, and more distant metastasis. High levels of Exo-pro and Exo-T were also correlated with more lymph node metastasis. Additionally, plasma from lung squamous cell carcinoma showed higher Exo-T and Exo-G compared with that from lung adenocarcinoma. ALK-positive patients showed to have decreased Exo-T and Exo-G levels. Pearson's correlation analysis revealed a significant correlation between Exo-pro and Exo-T/G, Exo-T and Exo-G, Exo-T and Plas-T, Exo-G and Plas-G, and Plas-T and Plas-G. Together

  9. PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

    International Nuclear Information System (INIS)

    Kong, Y; Zhang, J; Claxton, D F; Ehmann, W C; Rybka, W B; Zhu, L; Zeng, H; Schell, T D; Zheng, H

    2015-01-01

    Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed. T cells are pivotal in eradicating leukemia through a graft versus leukemia (GVL) effect and leukemia relapse is considered a failure of GVL. T-cell exhaustion is a state of T-cell dysfunction mediated by inhibitory molecules including programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain and mucin domain 3 (TIM-3). To evaluate whether T-cell exhaustion and inhibitory pathways are involved in leukemia relapse post alloSCT, we performed phenotypic and functional studies on T cells from peripheral blood of acute myeloid leukemia patients receiving alloSCT. Here we report that PD-1 hi TIM-3 + cells are strongly associated with leukemia relapse post transplantation. Consistent with exhaustion, PD-1 hi TIM-3 + T cells are functionally deficient manifested by reduced production of interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). In addition, these cells demonstrate a phenotype consistent with exhausted antigen-experienced T cells by losing T N and T EMRA subsets. Importantly, increase of PD-1 hi TIM-3 + cells occurs before clinical diagnosis of leukemia relapse, suggesting their predictive value. Results of our study provide an early diagnostic approach and a therapeutic target for leukemia relapse post transplantation

  10. W3C director Tim Berners-Lee to be Knighted by Queen Elizabeth web inventor recognized for contributions to internet development

    CERN Document Server

    2003-01-01

    "Tim Berners-Lee, the inventor of the World Wide Web and director of the World Wide Web Consortium (W3C), will be made a Knight Commander, Order of the British Empire (KBE) by Queen Elizabeth" (1/2 page).

  11. Up-regulated expression of Tim-3/Gal-9 at maternal-fetal interface in pregnant woman with recurrent spontaneous abortion.

    Science.gov (United States)

    Li, Jing; Li, Fan-fan; Zuo, Wei; Zhou, Yuan; Hao, Hai-yan; Dang, Jing; Jiang, Min; He, Meng-zhou; Deng, Dong-rui

    2014-08-01

    The relationship between T cell immunoglobulin domain and mucin domain protein 3 (Tim-3)/Galectin (Gal)-9 pathway and recurrent spontaneous abortion (RSA) was studied. Thirty-one pregnant women with RSA and 27 normal early gravidas were investigated to detect the levels of Tim-3 and Gal-9 in villi and deciduas by Western blotting. Meanwhile, the concentration of interleukin (IL)-4 and IL-12 in peripheral blood plasma was determined by ELISA in 25 healthy fertile non-pregnant controls, the normal early gravidas and pregnant women with RSA mentioned above, respectively. It was found that the relative expression levels of Tim-3 and Gal-9 in villi and deciduas were significantly increased in pregnant women with RSA as compared with those in the normal early gravidas. The concentration of IL-4 in peripheral blood plasma of pregnant women with RSA was lower than that of the normal early gravidas (Ppregnant controls (Ppregnant women with RSA was significantly higher than that of the normal early gravidas (Ppregnant controls (P<0.05). It was suggested that the overexpression of Tim-3/Gal-9 pathway may be related to the pathogenesis of RSA.

  12. TIMS analysis of Sr and Nd isotopes in melt inclusions from Italian potassium-rich lavas using prototype 1013Ω amplifiers

    NARCIS (Netherlands)

    Koornneef, Janne M.; Nikogosian, Igor; van Bergen, Manfred J.; Smeets, Richard; Bouman, Claudia; Davies, Gareth R.

    2015-01-01

    Sr and Nd isotopes were determined using new thermal ionisation mass spectrometry (TIMS) techniques for a suite of 21 olivine-hosted (85-92mol% Fo) melt inclusions selected from potassic and ultra-potassic lavas from the Italian peninsula. Sr isotopes were measured using default 1011Ω resistors,

  13. New sequential separation procedure for Sr, Nd and Pb isotope ratio measurement in geological material using MC-ICP-MS and TIMS

    Digital Repository Service at National Institute of Oceanography (India)

    Makishima, A.; Nath, B.N.; Nakamura, E.

    A new 3-step sequential separation chemistry for Sr, Nd and Pb from silicate samples, which is suitable for isotope analysis by MC-ICP-MS as well as TIMS, has been developed. The chemistry is designed to minimize the number of evaporation steps...

  14. Henry S. Turner, The English Renaissance Stage. Geometry, Poetics, and the Practical Spatial Arts 1580-1630 - Tim Fitzpatrick, Playwright, Space and Place in Early Modern Performance

    Directory of Open Access Journals (Sweden)

    Luigi Giuliani

    2013-05-01

    Full Text Available Review of Henry S. Turner, The English Renaissance Stage. Geometry, Poetics, and the Practical Spatial Arts 1580-1630, Oxford University Press, Oxford, 2006, reimpr. 2010, 326 pp. ISBN: 978-0-19-959545-7 y Tim Fitzpatrick, Playwright, Space and Place in Early Modern Performance, Ashgate, Franham, 2011, 314 pp. ISBN: 978-1-4094-2827-5.

  15. Use of 1012 ohm current amplifiers in Sr and Nd isotope analyses by TIMS for application to sub-nanogram samples

    NARCIS (Netherlands)

    Koornneef, J.M.; Bouman, C.; Schwieters, J.B.; Davies, G.R.

    2013-01-01

    We have investigated the use of current amplifiers equipped with 10 12 ohm feedback resistors in thermal ionisation mass spectrometry (TIMS) analyses of sub-nanogram sample aliquots for Nd and Sr isotope ratios. The results of analyses using the 1012 ohm resistors were compared to those obtained

  16. Pb isotope analysis of ng size samples by TIMS equipped with a 1013 Ω resistor using a 207Pb-204Pb double spike

    NARCIS (Netherlands)

    Klaver, M.; Smeets, R.J.; Koornneef, J.M.; Davies, G.R.; Vroon, P.Z.

    2016-01-01

    The use of the double spike technique to correct for instrumental mass fractionation has yielded high precision results for lead isotope measurements by thermal ionisation mass spectrometry (TIMS), but the applicability to ng size Pb samples is hampered by the small size of the

  17. IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Heon, Elise K. [University of Maryland Medical Center, Baltimore, MD 21201 (United States); Wulan, Hasi [Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing, 100853 (China); Macdonald, Loch P.; Malek, Adel O.; Braunstein, Glenn H.; Eaves, Connie G.; Schattner, Mark D. [Brown University, Providence, RI 02912 (United States); Allen, Peter M.; Alexander, Michael O.; Hawkins, Cynthia A.; McGovern, Dermot W.; Freeman, Richard L. [University of Wisconsin, Madison, WI 53706 (United States); Amir, Eitan P.; Huse, Jason D. [University of Illinois, Chicago, IL 60607 (United States); Zaltzman, Jeffrey S.; Kauff, Noah P.; Meyers, Paul G. [University of Texas, Austin, TX 78712 (United States); Gleason, Michelle H., E-mail: GleasonM@cblabs.org [University of Texas, Austin, TX 78712 (United States); Overholtzer, Michael G., E-mail: OverholtzerM@cblabs.org [University of Texas, Austin, TX 78712 (United States); Wiseman, Sam S. [Ohio State University, Columbus, OH 43210 (United States); and others

    2015-08-14

    IL-15 has pivotal roles in the control of CD8{sup +} memory T cells and has been investigated as a therapeutic option in cancer therapy. Although IL-15 and IL-2 share many functions together, including the stimulation of CD8 T cell proliferation and IFN-γ production, the different in vivo roles of IL-15 and IL-2 have been increasingly recognized. Here, we explored the different effects of IL-15 and IL-2 on tumor-infiltrating (TI) T cells from resected breast tumors. We found that neither IL-2 nor IL-15 induced intratumoral CD8 T cell proliferation by itself, but after CD3/CD28-stimulation, IL-15 induced significantly higher proliferation than IL-2 during early time points, at day 2, day 3 and day 6. However, the IL-15-induced proliferation leveled off at day 9 and day 12, whereas IL-2 induced lower but progressive proliferation at each time point. Furthermore, IL-15 caused an early and robust increase of IFN-γ in the supernatant of TI cell cultures, which diminished at later time points, while the IL-2-induced IFN-γ production remained constant over time. In addition, the IL-15-costimulated CD8 T cells presented higher frequencies of apoptotic cells. The diminishing IL-15-induced response was possibly due to regulatory and/or exhaustion mechanisms. We did not observe increased IL-10 or PD-1 upregulation, but we have found an increase of Tim-3 upregulation on IL-15-, but not IL-2-stimulated cells. Blocking Tim-3 function using anti-Tim-3 antibodies resulted in increased IL-15-induced proliferation and IFN-γ production for a prolonged period of time, whereas adding Tim-3 ligand galectin 9 led to reduced proliferation and IFN-γ production. Our results suggest that IL-15 in combination of Tim-3 blocking antibodies could potentially act as an IL-2 alternative in tumor CD8 T cell expansion in vitro, a crucial step in adoptive T cell therapy. - Highlights: • We explored the effects of IL-15 and IL-2 on tumor-infiltrating (TI) T cells of breast cancer. • IL-15

  18. Regulatory effect of gamma-chain cytokines on expression of TIM-3 on CD8+ T cells in patients with chronic hepatitis B

    Directory of Open Access Journals (Sweden)

    DONG Jie

    2015-02-01

    Full Text Available ObjectiveTo measure the expression of T-cell immunoglobulin- and mucin domain-3-containing molecule 3 (TIM-3 on CD8+ T cells in peripheral blood mononuclear cells (PBMCs among patients with chronic hepatitis B (CHB and to investigate the effect of common gamma-chain cytokines on the expression of TIM-3 on CD8+ T cells in these patients. MethodsFifteen previously untreated patients with CHB who visited the Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, from January to May, 2014, as well as 8 healthy controls, were included in the study. Blood was collected from these subjects, and PBMCs were isolated from blood by Ficoll density gradient centrifugation. PBMCs were separately stimulated with gamma-chain cytokines, interleukin (IL2, IL-7, IL-15, and IL-21, and anti-CD3/CD28, and the untreated cells were used as a negative control. After four days of culture, PBMCs were stained with monoclonal antibody. Flow cytometry was used to measure the expression of TIM-3 on CD8+ T cells. Comparison of continuous data was made by independent-samples t test. ResultsCompared with the untreated group, the anti-CD3/CD28, IL-2, IL-15, and IL-7 groups had significantly increased expression of TIM-3 on CD8+ T cells (9.629%±9.916%, P=0000 1; 3.817%±2.694%, P = 0.000 6; 5.772%±4.732%, P = 0.005 4; 3.560%±2.045%, P = 0.030 2, while the IL-21 group had nonsignificantly increased expression of TIM-3 on CD8+ T cells (2.503%±2.117%, P = 0.934 1. ConclusionAnti-CD3/CD28 and gamma-chain cytokines IL-2, IL-7, and IL-15 can effectively upregulate the expression of TIM-3 on CD8+ T cells in patients with CHB. It indicates that the inhibition of them can not only reduce the expression of TIM-3, but also may enhance the killing function of CD8+ T cells in patients with CHB.

  19. A novel method for sampling the suspended sediment load in the tidal environment using bi-directional time-integrated mass-flux sediment (TIMS) samplers

    Science.gov (United States)

    Elliott, Emily A.; Monbureau, Elaine; Walters, Glenn W.; Elliott, Mark A.; McKee, Brent A.; Rodriguez, Antonio B.

    2017-12-01

    Identifying the source and abundance of sediment transported within tidal creeks is essential for studying the connectivity between coastal watersheds and estuaries. The fine-grained suspended sediment load (SSL) makes up a substantial portion of the total sediment load carried within an estuarine system and efficient sampling of the SSL is critical to our understanding of nutrient and contaminant transport, anthropogenic influence, and the effects of climate. Unfortunately, traditional methods of sampling the SSL, including instantaneous measurements and automatic samplers, can be labor intensive, expensive and often yield insufficient mass for comprehensive geochemical analysis. In estuaries this issue is even more pronounced due to bi-directional tidal flow. This study tests the efficacy of a time-integrated mass sediment sampler (TIMS) design, originally developed for uni-directional flow within the fluvial environment, modified in this work for implementation the tidal environment under bi-directional flow conditions. Our new TIMS design utilizes an 'L' shaped outflow tube to prevent backflow, and when deployed in mirrored pairs, each sampler collects sediment uniquely in one direction of tidal flow. Laboratory flume experiments using dye and particle image velocimetry (PIV) were used to characterize the flow within the sampler, specifically, to quantify the settling velocities and identify stagnation points. Further laboratory tests of sediment indicate that bidirectional TIMS capture up to 96% of incoming SSL across a range of flow velocities (0.3-0.6 m s-1). The modified TIMS design was tested in the field at two distinct sampling locations within the tidal zone. Single-time point suspended sediment samples were collected at high and low tide and compared to time-integrated suspended sediment samples collected by the bi-directional TIMS over the same four-day period. Particle-size composition from the bi-directional TIMS were representative of the array of

  20. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9.

    Science.gov (United States)

    Schwartz, Jordan Ari; Clayton, Kiera L; Mujib, Shariq; Zhang, Hongliang; Rahman, A K M Nur-Ur; Liu, Jun; Yue, Feng Yun; Benko, Erika; Kovacs, Colin; Ostrowski, Mario A

    2017-04-15

    In chronic diseases, such as HIV infection, plasmacytoid dendritic cells (pDCs) are rendered dysfunctional, as measured by their decreased capacity to produce IFN-α. In this study, we identified elevated levels of T cell Ig and mucin-domain containing molecule-3 (Tim-3)-expressing pDCs in the blood of HIV-infected donors. The frequency of Tim-3-expressing pDCs correlated inversely with CD4 T cell counts and positively with HIV viral loads. A lower frequency of pDCs expressing Tim-3 produced IFN-α or TNF-α in response to the TLR7 agonists imiquimod and Sendai virus and to the TLR9 agonist CpG. Thus, Tim-3 may serve as a biomarker of pDC dysfunction in HIV infection. The source and function of Tim-3 was investigated on enriched pDC populations from donors not infected with HIV. Tim-3 induction was achieved in response to viral and artificial stimuli, as well as exogenous IFN-α, and was PI3K dependent. Potent pDC-activating stimuli, such as CpG, imiquimod, and Sendai virus, induced the most Tim-3 expression and subsequent dysfunction. Small interfering RNA knockdown of Tim-3 increased IFN-α secretion in response to activation. Intracellular Tim-3, as measured by confocal microscopy, was dispersed throughout the cytoplasm prior to activation. Postactivation, Tim-3 accumulated at the plasma membrane and associated with disrupted TLR9 at the submembrane. Tim-3-expressing pDCs had reduced IRF7 levels. Furthermore, intracellular Tim-3 colocalized with p85 and IRF7 within LAMP1 + lysosomes, suggestive of a role in degradation. We conclude that Tim-3 is a biomarker of dysfunctional pDCs and may negatively regulate IFN-α, possibly through interference with TLR signaling and recruitment of IRF7 and p85 into lysosomes, enhancing their degradation. Copyright © 2017 by The American Association of Immunologists, Inc.

  1. Fakultas Ekonomi Universitas Muhammadiyah Surakarta

    Directory of Open Access Journals (Sweden)

    Wuryaningsih DL Wuryaningsih DL

    2013-12-01

    because the value of the current ratio is less than 200% is equal to 94% in 2008 and 97% in 2009, (b the financial performance of banks in 2008-2009 categorized not good, as measured by the quick ratio, quick ratio because the value is less than 100% is equal to 94% in 2008 and 97% in 2009, (cthe financial performance of banks in 2008-2009 categorized not good, measured from the cash ratio, because the value of the cash ratio less than 100% which is 28% in 2008 and 32% in 2009.(2 solvency ratio: (athe financial performance of banks in 2008-2009 categorized solvable measured by debt to net worth, because the value of debt to net worth of mo re than 25% in the amount of 942% in 2008 and 840% in 2009, (b the financial performance of banks in 2008-2009 categorized solvable, measured by total assets to net worth, because the value of total assets to net worth of more than 25% is equal to 1082% i n 2008 and 970% in 2009, (c the financial performance of banks in 2008-2009 categorized insolvable measured from fixed assets to net worth, as value of fixed assets to net worth less than 25% at 15% in 2008 and 12% in 2009.(3 The ratio of earnings: (a the banking company for the year 2008-2009 is still a very small benefit only Rp 0.0185,00 in 2008 and Rp 0.0223,00 in 2009, (b the banking company for the year 2008-2009 is still a very small benefit from its own capital only Rp 0.15,00 in 2008 and Rp 0.17,00 in 2009

  2. UK Institute of Physics (IOP) President Sir Gareth Roberts (right) at CERN on 9 July with (right to left) IOP council vice-president and distinguished physicist Peter Kalmus, CERN engineer Tim Watson and IOP director of science Peter Cooper

    CERN Multimedia

    Patrice Loiez

    1999-01-01

    UK Institute of Physics (IOP) President Sir Gareth Roberts (right) at CERN on 9 July with (right to left) IOP council vice-president and distinguished physicist Peter Kalmus, CERN engineer Tim Watson and IOP director of science Peter Cooper

  3. Tim Burton lavastab Batmani muusikali. Placido Domingo palkas "Star Warsi" võluri. MTV muusikaauhindade show'l narriti Michael Jacksonit. Hendrixi põlenud kitarr läheb müüki

    Index Scriptorium Estoniae

    2002-01-01

    Jim Steinman kirjutab muusikat Tim Burtoni 2005. aastal lavale tulevale Batmani muusikalile. Los Angelese ooperimaja juht Domingo palkas George Lucase Wagneri ooperi "Nibelungide sõrmus" eriefektide ettevalmistamiseks. Britney Spears nimetas Michael Jacksonit Millenniumi artistiks.

  4. Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1.

    Science.gov (United States)

    Darwish, Noureldien H E; Sudha, Thangirala; Godugu, Kavitha; Elbaz, Osama; Abdelghaffar, Hasan A; Hassan, Emad E A; Mousa, Shaker A

    2016-09-06

    Acute myeloid leukemia (AML) patients show high relapse rates and some develop conventional chemotherapy resistance. Leukemia Stem Cells (LSCs) are the main player for AML relapses and drug resistance. LSCs might rely on the B-cell-specific Moloney murine leukemia virus integration site-1 (BMI-1) in promoting cellular proliferation and survival. Growth of LSCs in microenvironments that are deprived of nutrients leads to up-regulation of the signaling pathways during the progression of the disease, which may illustrate the sensitivity of LSCs to inhibitors of those signaling pathways as compared to normal cells. We analyzed the expression of LSC markers (CD34, CLL-1, TIM-3 and BMI-1) using quantitative RT-PCR in bone marrow samples of 40 AML patients of different FAB types (M1, M2, M3, M4, M5, and M7). We also studied the expression of these markers in 2 AML cell lines (Kasumi-1 and KG-1a) using flow cytometry and quantitative RT-PCR. The overexpression of TIM-3, CLL-1, and BMI-1 was markedly correlated with poor prognosis in these patients. Our in vitro findings demonstrate that targeting BMI-1, which markedly increased in the leukemic cells, was associated with marked decrease in leukemic burden. This study also presents results for blocking LSCs' surface markers CD44, CLL-1, and TIM-3. These markers may play an important role in elimination of AML. Our study indicates a correlation between the expression of markers TIM-3, CLL-1, and especially of BMI-1 and the aggressiveness of AML and thus the potential impact of prognosis and therapies that target LSCs on improving the cure rates.

  5. Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.

    Science.gov (United States)

    Linedale, Richard; Schmidt, Campbell; King, Brigid T; Ganko, Annabelle G; Simpson, Fiona; Panizza, Benedict J; Leggatt, Graham R

    2017-01-01

    Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.

  6. Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.

    Directory of Open Access Journals (Sweden)

    Richard Linedale

    Full Text Available Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.

  7. An improved FT-TIMS method of measuring uranium isotope ratios in the uranium-bearing particles

    International Nuclear Information System (INIS)

    Chen, Yan; Wang, Fan; Zhao, Yong-Gang; Li, Li-Li; Zhang, Yan; Shen, Yan; Chang, Zhi-Yuan; Guo, Shi-Lun; Wang, Xiao-Ming; Cui, Jian-Yong; Liu, Yu-Ang

    2015-01-01

    An improved method of Fission Track technique combined with Thermal Ionization Mass Spectrometry (FT-TIMS) was established in order to determine isotope ratio of uranium-bearing particle. Working standard of uranium oxide particles with a defined diameter and isotopic composition were prepared and used to review the method. Results showed an excellent agreement with certified values. The developed method was used to analyze isotope ratio of single uranium-bearing particle in swipe samples successfully. The analysis results of uranium-bearing particles in swipe samples accorded with the operation history of the origin. - Highlights: • The developed method was successfully applied in the analysis of real swipe sample. • Uranium-bearing particles were confined in the middle of track detector. • The fission tracks of collodion film and PC film could be confirmed each other. • The thickness of collodion film should be no more than about 60 μm. • The method could avoid losing uranium-bearing particles in the etching step.

  8. A comparative study of isotopic analysis of plutonium from organic and aqueous media by thermal ionization mass spectrometry (TIMS)

    International Nuclear Information System (INIS)

    Rao, Radhika M.; Mirashi, Nirupama N.; Khodade, P.S.; Shah, P.M.; Parab, A.R.; Govindan, R.; Aggarwal, S.K.

    2003-01-01

    For isotopic analysis of plutonium (Pu) in irradiated nuclear fuel samples, it is normally separated from Am, U and fission products by anion exchange method in nitrate medium. However, stripping of Pu from the column by dilute HNO 3 acid is slow due to tailing which requires long elution times and reduces the concentration of Pu in the eluted solution. The desorption of Pu from the column can be enhanced by using more dilute HNO 3 but there are problems of hydrolysis and polymer formation. Formic acid and ascorbic acid in formic acid are reported to be promising eluents for plutonium. Formic acid is also a good solvent for Pu. Further, the presence of ascorbic acid helps in reducing Pu (IV) to Pu (III) thereby leading to faster elution as well as better recovery in smaller volumes of the eluant and hence higher Pu concentrations in the collected fraction. This would circumvent the need of subsequent concentration steps allowing direct loading of Pu on the filament for analysis by TIMS. The aim of the present work was to compare the elution behaviour and mass spectrometric analysis of Pu using formic acid, formic acid + ascorbic acid and nitric acid with respect to ion current behaviour and isotopic ratios obtained

  9. Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1).

    Science.gov (United States)

    Ribnicky, David M; Roopchand, Diana E; Oren, Andrew; Grace, Mary; Poulev, Alexander; Lila, Mary Ann; Havenaar, Robert; Raskin, Ilya

    2014-01-01

    The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions. Blueberry polyphenol-rich extract was delivered to TIM-1 in the absence or presence of a high-fat meal. HPLC analysis of seventeen anthocyanins showed that delphinidin-3-glucoside, delphinidin-3-galactoside, delphinidin-3-arabinoside and petunidin-3-arabinoside were twice as bioaccessible in fed state, whilst delphinidin-3-(6″-acetoyl)-glucoside and malvidin-3-arabinoside were twice as bioaccessible under fasted conditions, suggesting lipid-rich matrices selectively effect anthocyanin bioaccessibility. TIM-1 was fed blueberry juice (BBJ) or blueberry polyphenol-enriched defatted soybean flour (BB-DSF) containing equivalent amounts of free or DSF-sorbed anthocyanins, respectively. Anthocyanin bioaccessibility from BB-DSF (36.0±10.4) was numerically, but not significantly, greater than that from BBJ (26.3±10.3). Ileal efflux samples collected after digestion of BB-DSF contained 2.8-fold more anthocyanins than same from BBJ, suggesting that protein-rich DSF protects anthocyanins during transit through upper digestive tract for subsequent colonic delivery/metabolism. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis.

    Science.gov (United States)

    Fleury, Michelle; Belkina, Anna C; Proctor, Elizabeth A; Zammitti, Christopher; Simms, Robert W; Lauffenburger, Douglas A; Snyder-Cappione, Jennifer E; Lafyatis, Robert; Dooms, Hans

    2018-04-01

    Immune dysfunction is an important component of the disease process underlying systemic sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. This study was undertaken to measure the expression and function of the coinhibitory receptors (co-IRs) programmed cell death 1 (PD-1), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin domain 3 (TIM-3), and lymphocyte activation gene 3 (LAG-3) in lymphocyte subsets from the peripheral blood of patients with SSc. Co-IR expression levels on subsets of immune cells were analyzed using a 16-color flow cytometry panel. The functional role of co-IRs was determined by measuring cytokine production after in vitro stimulation of SSc and healthy control peripheral blood mononuclear cells (PBMCs) in the presence of co-IR-blocking antibodies. Supernatants from cultures of stimulated PBMCs were added to SSc fibroblasts, and their impact on fibroblast gene expression was measured. Mathematical modeling was used to reveal differences between co-IR functions in SSc patients and healthy controls. Levels of the co-IRs PD-1 and TIGIT were increased, and each was coexpressed, in distinct T cell subsets from SSc patients compared to healthy controls. Levels of TIM-3 were increased in SSc natural killer cells. PD-1, TIGIT, and TIM-3 antibody blockade revealed patient-specific roles of each of these co-IRs in modulating activation-induced T cell cytokine production. In contrast to healthy subjects, blockade of TIGIT and TIM-3, but not PD-1, failed to reverse inhibited cytokine production in SSc patients, indicating that enhanced T cell exhaustion is present in SSc. Finally, cytokines secreted in anti-TIM-3-treated PBMC cultures distinctly changed the gene expression profile in SSc fibroblasts. The altered expression and regulatory capacity of co-IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine-mediated cross-talk of

  11. Determinants in the Ig Variable Domain of Human HAVCR1 (TIM-1) Are Required To Enhance Hepatitis C Virus Entry.

    Science.gov (United States)

    Kachko, Alla; Costafreda, Maria Isabel; Zubkova, Iryna; Jacques, Jerome; Takeda, Kazuyo; Wells, Frances; Kaplan, Gerardo; Major, Marian E

    2018-03-15

    Hepatitis C virus (HCV) is the leading cause of chronic hepatitis in humans. Several host molecules participate in HCV cell entry, but this process remains unclear. The complete unraveling of the HCV entry process is important to further understand viral pathogenesis and develop therapeutics. Human hepatitis A virus (HAV) cellular receptor 1 (HAVCR1), CD365, also known as TIM-1, functions as a phospholipid receptor involved in cell entry of several enveloped viruses. Here, we studied the role of HAVCR1 in HCV infection. HAVCR1 antibody inhibited entry in a dose-dependent manner. HAVCR1 soluble constructs neutralized HCV, which did not require the HAVCR1 mucinlike region and was abrogated by a mutation of N to A at position 94 (N94A) in the Ig variable (IgV) domain phospholipid-binding pocket, indicating a direct interaction of the HAVCR1 IgV domain with HCV virions. However, knockout of HAVCR1 in Huh7 cells reduced but did not prevent HCV growth. Interestingly, the mouse HAVCR1 ortholog, also a phospholipid receptor, did not enhance infection and a soluble form failed to neutralize HCV, although replacement of the mouse IgV domain with the human HAVCR1 IgV domain restored the enhancement of HCV infection. Mutations in the cytoplasmic tail revealed that direct HAVCR1 signaling is not required to enhance HCV infection. Our data show that the phospholipid-binding function and other determinant(s) in the IgV domain of human HAVCR1 enhance HCV infection. Although the exact mechanism is not known, it is possible that HAVCR1 facilitates entry by stabilizing or enhancing attachment, leading to direct interactions with specific receptors, such as CD81. IMPORTANCE Hepatitis C virus (HCV) enters cells through a multifaceted process. We identified the human hepatitis A virus cellular receptor 1 (HAVCR1), CD365, also known as TIM-1, as a facilitator of HCV entry. Antibody blocking and silencing or knockout of HAVCR1 in hepatoma cells reduced HCV entry. Our findings that the

  12. High-Resolution Zircon U-Pb CA-TIMS Dating of the Carboniferous—Permian Successions, Paraná Basin, Brazil

    Science.gov (United States)

    Griffis, N. P.; Mundil, R.; Montanez, I. P.; Isbell, J.; Fedorchuk, N.; Lopes, R.; Vesely, F.; Iannuzzi, R.

    2015-12-01

    The late Paleozoic Ice Age (LPIA) is Earth's only record of a CO2-forced climatic transition from an icehouse to greenhouse state in a vegetated world. Despite a refined framework of Gondwanan ice distribution, questions remain about the timing, volume, and synchronicity of high-latitude continental ice and the subsequent deglaciation. These questions ultimately preclude our understanding of linkages between ice volume, sea level, and high- and low-latitude climate. Poor constraints on the timing and synchronicity of glacial and interglacial transitions reflect a lack of high-resolution radioisotopic dates from high-latitude, ice-proximal Carboniferous-Permian successions. The Rio Bonito Fm in Rio Grande do Sul State of southern Brazil hosts the oldest non-glaciogenic Carboniferous- Permian deposits of the Paraná Basin, thus recording the icehouse-to-greenhouse transition. Despite a widespread effort over the last two decades to constrain these deposits in time by means of U-Pb zircon geochronology, published data sets of the Candiota and Faxinal coals of the Rio Bonito Fm host discrepancies that may reflect post- eruptive open system behavior of zircon and analytical artifacts. These discrepancies have hindered the correlation of the Candiota and Faxinal sediments within the larger Gondwanan framework. Here we present the first U-Pb ages on closed system single zircons using CA-TIMS techniques on Permo-Carboniferous ash deposits of the Paraná Basin. Preliminary results indicate two major and distinct coal-forming periods that are separated by ca 10 Ma. Our results and conclusions are not in agreement with multi- crystal U-Pb TIMS and SIMS ages that suggest coeval deposition of the Candiota and Faxinal coals. CA-TIMS analyses applied to zircons from additional ash deposits are aimed at constructing a robust chronostratigraphic framework for the Carboniferous- Permian succession of the Paraná Basin, which will facilitate a better understanding of the timing and

  13. The technique of express vital determination of radiocesium specific activity in muscular tissue of large agricultural animals by means of the TIM-140 radiometer

    International Nuclear Information System (INIS)

    1997-01-01

    The technique is intended for vital determination of cesium 137 specific activity in muscular tissue of large agricultural animals by means of the TIM-140 radiometer. The specific activity is determined using two measurements. With one measurement the gamma radiation detector is located on a lateral surface of coxofemoral part of the animal, and with the second measurement the absorbing gamma radiation screen is placed between the detector and zone of measurement. The external gamma background and useful signal are registered simultaneously. It allows to carry out measurements with a background till 0.05 mR/h without application of external screens

  14. The de-totalization of history in Tim O`Brien`s The Things They Carried (1990DOI:10.5007/2175-8026.2010n59p13

    Directory of Open Access Journals (Sweden)

    Gisele Manganelli Fernandes

    2010-03-01

    Full Text Available This paper aims at discussing how Tim O’Brien, a veteran of the Vietnam War, reviews the American involvement in the conflict in his novel The Things They Carried (1990. The author shows the perspective of the soldiers in the stories and, therefore, presents other possibilities to analyze that historical fact. The interplay of fiction and truth is essential for O’Brien to reach the objective of reevaluating official history in order to make the readers rethink the past.

  15. Mengelola Proses Tim

    OpenAIRE

    Raharso, Sri

    2012-01-01

    Work teams has become relatively common in organizations because brilliant execution that can onlybe done with teamwork. A team as a group of individuals who work together under a unity of purpose,as a united front. But develop team is not easy, take some years. When team leaders focus primarily onhard business tools, such as schedule, budget, and scope, they can lose sight of a more subjective aspectof the project—the team member. Each person brings a unique set of experiences and knowledge ...

  16. The TiM system: developing a novel telehealth service to improve access to specialist care in motor neurone disease using user-centered design.

    Science.gov (United States)

    Hobson, Esther V; Baird, Wendy O; Partridge, Rebecca; Cooper, Cindy L; Mawson, Susan; Quinn, Ann; Shaw, Pamela J; Walsh, Theresa; Wolstenholme, Daniel; Mcdermott, Christopher J

    2018-08-01

    Attendance at a specialist multidisciplinary motor neurone disease (MND) clinic is associated with improved survival and may also improve quality of life and reduce hospital admissions. However, patients struggle to travel to clinic and may experience difficulties between clinic visits that may not be addressed in a timely manner. We wanted to explore how we could improve access to specialist MND care. We adopted an iterative, user-centered co-design approach, collaborating with those with experience of providing and receiving MND care including patients, carers, clinicians, and technology developers. We explored the unmet needs of those living with MND, how they might be met through service redesign and through the use of digital technologies. We developed a new digital solution and performed initial testing with potential users including clinicians, patients, and carers. We used these findings to develop a telehealth system (TiM) using an Android app into which patients and carers answer a series of questions about their condition on a weekly basis. The questions aim to capture all the physical, emotional, and social difficulties associated with MND. This information is immediately uploaded to the internet for review by the MND team. The data undergoes analysis in order to alert clinicians to any changes in a patient or carer's condition. We describe the benefits of developing a novel digitally enabled service underpinned by participatory design. Future trials must evaluate the feasibility and acceptability of the TiM system within a clinical environment.

  17. Digestion of cooked meat proteins is slightly affected by age as assessed using the dynamic gastrointestinal TIM model and mass spectrometry.

    Science.gov (United States)

    Denis, S; Sayd, T; Georges, A; Chambon, C; Chalancon, S; Santé-Lhoutellier, V; Blanquet-Diot, S

    2016-06-15

    In humans, meat ensures the supply of proteins with high nutritional value and indispensable amino acids. The main goal of the present study was to compare the degradation of meat proteins in adult and elderly digestive conditions. Cooked meat was subjected to in vitro digestion in the dynamic multi-compartmental TIM (TNO gastroIntestinal Model) system. Digestibility and bioaccessibility were determined using nitrogen balance and digestion products were identified using mass spectrometry. The TIM model was adapted according to in vivo data to mimic the specific digestive conditions of elderly people. Meat protein digestibility and bioaccessibility were around 96 and 60% respectively and were not influenced by age (P > 0.05). As much as 800 peptides were identified in the duodenal and jejunal compartments issued from 50 meat proteins with a percentage of coverage varying from 13 to 69%. Six proteins, mainly from the cytosol, were differentially hydrolyzed under the adult and elderly digestive conditions. Pyruvate kinase was the only protein clearly showing a delay in its degradation under elderly digestive conditions. This study provides significant insights into the understanding of meat protein dynamic digestion. Such data will be helpful to design in vivo studies aiming to evaluate dietary strategies that can attenuate muscle mass loss and more generally maintain a better quality of life in the elderly population.

  18. Isotope ratio measurements of pg-size plutonium samples using TIMS in combination with the 'Multiple Ion Counting' and filament carburization

    Energy Technology Data Exchange (ETDEWEB)

    Jakopic, Rozle; Richter, Stephan; Kuehn, Heinz; Aregbe, Yetunde [European Commission, Directorate General Joint Research Centre Institute for Reference Materials and Measurements, IRMM Retieseweg 111, B-2440 Geel (Belgium)

    2008-07-01

    A new sample preparation procedure for isotopic measurements using the Triton TIMS (Thermal Ionization Mass Spectrometer) was developed which employed the technique of carburization of rhenium filaments. Carburized filaments were prepared in a special vacuum chamber in which the filaments were heated and exposed to benzene vapor. Ionization efficiency was improved by an order of magnitude. Additionally, a new 'multi-dynamic' measurement technique was developed for Pu isotope ratio measurements using the 'multiple ion counting' (MIC) system. This technique was further combined with the filament carburization technique and applied to the NBL-137 isotopic standard and samples of the NUSIMEP 5 inter-laboratory comparison campaign. The results clearly show an improved precision and accuracy for the 'multi-dynamic' measurement procedure, compared to measurements carried out either in peak-jumping or in static mode using the MIC system with non-carburized filaments. (authors)

  19. Fleeing War. Due strategie di diserzione letteraria:I parenti del Sud di Carlo Montella e Going After Cacciato di Tim O’Brien

    Directory of Open Access Journals (Sweden)

    Giulio Segato

    2014-10-01

    Full Text Available Il saggio indaga due diverse strategie di diserzione rappresentate in due romanzi di guerra: I parenti del sud di Carlo Montella e Going After Cacciato di Tim O’Brien. Nelle due opere analizzate la diserzione sembra essere collegata al conflitto che fa da sfondo al romanzo. Nel libro di Montella,il protagonista, ancora obnubilato dalle dottrine tautologiche fasciste, qualche settimana dopo l’armistizio di Cassibile decide di disertare e di fuggire nella villa di un’anziana parente, con lo scopo di rinsavire dall’ideologia del regime. Nel romanzo di O’Brien, invece, la fuga messa in scena dall’autore sembra avere gli stessi tratti grotteschi e assurdi del conflitto in cui è stato catapultato il protagonista,la Guerra del Vietnam.

  20. Radiogenic Isotopes As Paleoceanographic Tracers in Deep-Sea Corals: Advances in TIMS Measurements of Pb Isotopes and Application to Southern Ocean Corals

    Science.gov (United States)

    Wilson, D. J.; van de Flierdt, T.; Bridgestock, L. J.; Paul, M.; Rehkamper, M.; Robinson, L. F.; Adkins, J. F.

    2014-12-01

    Deep-sea corals have emerged as a valuable archive of deep ocean paleoceanographic change, with uranium-series dating providing absolute ages and the potential for centennial resolution. In combination with measurements of radiocarbon, neodymium isotopes and clumped isotopes, this archive has recently been exploited to reconstruct changes in ventilation, water mass sourcing and temperature in relation to millennial climate change. Lead (Pb) isotopes in both corals and seawater have also been used to track anthropogenic inputs through space and time and to trace transport pathways within the oceans. Better understanding of the oceanic Pb cycle is emerging from the GEOTRACES programme. However, while Pb isotopes have been widely used in environmental studies, their full potential as a (pre-anthropogenic) paleoceanographic tracer remains to be exploited. In deep-sea corals, challenges exist from low Pb concentrations in aragonite in comparison to secondary coatings, the potential for contamination, and the efficient elemental separation required for measurement by thermal ionisation mass spectrometry (TIMS). Here we discuss progress in measuring Pb isotopes in coral aragonite using a 207Pb-204Pb double spike on a ThermoFinnigan Triton TIMS. For a 2 ng NIST-981 Pb standard, the long term reproducibility (using 1011 Ω resistors) is ~1000 ppm (2 s.d.) on 206Pb/204Pb, 207Pb/204Pb and 208Pb/204Pb ratios. We now show that using a new 1012 Ω resistor to measure the small 204Pb beam improves the internal precision on these ratios from ~500 ppm (2 s.e.) to ~250 ppm (2 s.e.) and we envisage a potential improvement in the long term reproducibility as a consequence. We further assess the internal precision and external reproducibility of our method using a BCR-2 rock standard and an in-house coral standard. Preliminary evidence on the application of this method to natural samples is derived from cleaning experiments and replication tests on deep-sea corals from the Southern

  1. Bacillus coagulans GBI-30, 6086 increases plant protein digestion in a dynamic, computer-controlled in vitro model of the small intestine (TIM-1).

    Science.gov (United States)

    Keller, D; Van Dinter, R; Cash, H; Farmer, S; Venema, K

    2017-05-30

    The aim of this study was to assess the potential of the probiotic Bacillus coagulans GBI-30, 6086 [GanedenBC 30 ] (BC30) to aid in protein digestion of alimentary plant proteins. To test this, three plant proteins, from pea, soy and rice, were digested in a validated in vitro model of the stomach and small intestine (TIM-1) in the absence and in the presence of BC30. Samples were taken from the TIM-1 fractions that mimic uptake of amino acids by the host and analysed for α-amino nitrogen (AAN) and total nitrogen (TN). Both were increased by BC30 for all three plant proteins sources. The ratio of TN/AAN indicated that for pea protein digestion was increased by BC30, but the degree of polymerisation of the liberated small peptides and free amino acids was not changed. For soy and rice, however, BC30 showed a 2-fold reduction in the TN/AAN ratio, indicating that the liberated digestion products formed during digestion in the presence of BC30 were shorter peptides and more free amino acids, than those liberated in the absence of BC30. As BC30 increased protein digestion and uptake in the upper gastrointestinal (GI) tract, it consequently also reduced the amount of protein that would be delivered to the colon, which could there be fermented into toxic metabolites by the gut microbiota. Thus, the enhanced protein digestion by BC30 showed a dual benefit: enhanced amino acid bioavailability from plant proteins in the upper GI tract, and a healthier environment in the colon.

  2. Permian U-Pb (CA-TIMS) zircon ages from Australia and China: Constraining the time scale of environmental and biotic change

    Science.gov (United States)

    Denyszyn, S. W.; Mundil, R.; Metcalfe, I.; He, B.

    2010-12-01

    In eastern Australia, the interconnected Bowen and Sydney Basins are filled with terrestrial sediments of late Paleozoic to early Mesozoic age. These sedimentary units record significant evolutionary events of eastern Gondwana during the time interval between two major mass extinctions (end Middle Permian and Permian-Triassic), and also provide lithological evidence for the Carboniferous-Permian Late Paleozoic Ice Age of southern Pangea, considered to be divisible into up to seven discrete glaciation events in Australia [e.g., 1]. These glaciations are currently assigned ages that indicate that the last of the glaciations predate the end Middle Permian mass extinction at ca. 260 Ma. However, the estimates for the time and durations are largely based on biostratigraphy and lithostratigraphy that, in the absence of robust and precise radioisotopic ages, are unacceptably fragile for providing an accurate high-resolution framework. Interbedded with the sediments are numerous tuff layers that contain zircon, many of which are associated with extensive coal measures in the Sydney and Bowen Basins. Published SHRIMP U-Pb zircon ages [2, 3] have been shown to be less precise and inaccurate when compared to ages applying the CA-TIMS method to the same horizons. Also within the late Middle Permian, the eruption of the Emeishan flood basalts in SW China has been proposed to have caused the end Middle Permian mass extinction [e.g., 4], though a causal link between these events demands a rigorous test that can only be provided by high-resolution geochronology. We present new U-Pb (CA-TIMS) zircon ages on tuff layers from the Sydney and Bowen Basins, with the purpose of generating a timescale for the Upper Permian of Australia to allow correlation with different parts of the world. Initial results, with permil precision, date a tuff layer within the uppermost Bandanna Fm. to ca. 252 Ma, a tuff within the Moranbah Coal Measures to ca. 256 Ma, and a tuff within the Ingelara Fm. to

  3. Development of CA-ID-TIMS zircon U–Pb dating technique at Guangzhou Institute of Geochemistry, Chinese Academy of Sciences

    Directory of Open Access Journals (Sweden)

    Yu-Ting Zhong

    2017-06-01

    Pretreatment protocols for zircon analysis, and community-wide innovations spurred on by EARTHTIME tends to be at the leading edge of technological development. Also, more and more Chinese researchers perform lots of laboratory work in improving the technique in China. Here we present the running condition, procedural blanks and zircon standards measurement results in the clean laboratory of the Guangzhou Institute of Geochemistry, Chinese Academy of Sciences (GIGCAS. The results show the total procedural blanks (Pbc are below ∼1 pg mostly, suitable for the sample pretreatment and operation. The 206Pb/238U dates of R33 and 500 Ma solution are 419.88 ± 0.94 Ma (n = 7; MSWD = 6.8 and 500.50 ± 0.19 Ma (n = 9; MSWD = 0.84, respectively. These results demonstrate that the CA-ID-TIMS procedure is well established at GIGCAS. Our efforts are beneficial to the development of EARTHTIME-CN program. In particular, when this technique is combined with the SIMS technique, it provides an efficient way to solve a number of geochronological problems encountered in China and worldwide.

  4. Clay minerals in uraniferous deposit of Imouraren (Tim Mersoi basin, Niger): implications on genesis of deposit and on ore treatment process

    International Nuclear Information System (INIS)

    Billon, Sophie

    2014-01-01

    Nigerian uraniferous deposits are located in carboniferous and Jurassic formations of Tim Mersoi basin. AREVA is shareholder of 3 mine sites in this area: SOMAIR and COMINAK, both in exploitation since 1960's and IMOURAREN, 80 km further South, whose exploitation is planned for 2015. Mineralization of Imouraren deposit is included in the fluvial formation of Tchirezrine 2 (Jurassic), composed of channels and flood plains. Facies of channel in-fillings range from coarse sandstones to siltstones, while overflow facies are composed of analcimolites. Secondary mineralogy was acquired during 2 stages: 1- diagenesis, with formation of clay minerals, analcime, secondary quartz and albites, and 2- stage of fluids circulations, which induced alteration of detrital and diagenetic minerals, formation of new phases and uranium deposition. A mineralogical zoning, at the scale of deposit resulted from this alteration. The heterogeneity of Tchirezrine 2, at the level of both facies and mineralogy, is also evidenced during ore treatment, as ore reacts differently depending on its source, with sometimes problems of U recovery. Ore treatment tests showed that analcimes and chlorites were both penalizing minerals, because of 1- the sequestration of U-bearing minerals into analcimes, 2- their dissolution which trends to move away from U solubilization conditions (pH and Eh) and to form numerous sulfates, and 3- problems of percolation. A detection method of analcime-rich ores, based on infrared spectroscopy, was developed in order to optimize ore blending and so to reduce negative effects during ore treatment process. (author)

  5. High-precision timing of Nanhai coral by using MC-ICP-MS and TIMS techniques and its paleo-environmental significance

    International Nuclear Information System (INIS)

    Peng Zicheng; Nie Baofu; Chen Tegu

    2004-01-01

    The techniques of thermal ionization mass spectrometry (TIMS) and multicollector-inductively coupled plasma-mass spectrometry (MC-ICP-MS) were used for the high-precision timing of the domestic stalagmite standard (GBW04412), international coral standard (RKM-4) and the Nanhai corals. The results of uranium contents and the ratios of 234 U/ 238 U and 230 Th/ 234 U in the two standards measured by using two techniques were consistent within the error range. Most of the Nanhai corals have less than 3 μg/g of the uranium contents and 150 ± 5 of the δ 234 U(T) values, which means that the corals have not been subjected to the alternation since they were brought up 7000 years ago, therefore, they preserve the original environmental signals. The age sequence of the corals shows that three events of the high sea level happened in Nanhai area in the periods corresponding to 6799-6307 a B.P., 4472-4285 a B.P. and 1279-1012 a B.P. respectively. The above-mentioned three stages were relative to the Megathermal and Medieval Warm Periods in our country. (authors)

  6. Jurusan Akuntansi Fakultas Ekonomi Universitas Udayana

    Directory of Open Access Journals (Sweden)

    I PUTU ADNYANA USADHA

    2009-07-01

    Full Text Available The purpose of this research is to gain empirical evidence whetheracquiring companies conduct earnings management before the execution ofmerger and acquisition. It also aims to investigate performance changes ofacquiring companies before and after merger and acquisition.Earnings management conducted by the companies is proxied bydiscretionary accrual (DA. Analysis is done using independent sample ttestand paired sample test. The result shows that there is an indication ofearnings management done by taking over companies before merger andacquisition by utilizing income increasing accruals. Furthermore, thefinancial performance of the companies is lower after merger andacquisition took place.

  7. TRACER STUDY FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA

    Directory of Open Access Journals (Sweden)

    Darma Rika Swaramarinda

    2014-03-01

    Full Text Available This study was conducted to identify the competencies of graduates FE UNJ waiting times based upon the profile of the work , the suitability of the first areas of work, salary and perceptions about the competence of the alumni corporation. This research is a qualitative study and the population are alumni of the Faculty of Economics who working in government agencies, private and entrepreneur and graduated from the period 2011/2012 to 2012/2013. Sample of the population is set at 10 % of the total population, and using a technique convenience sampling ( non probability sampling . The data used in this study is primary data obtained from interviews and use the questionnaire instrument. Data were analyzed using descriptive statistics by looking at the frequency distribution and the average of respondents answers regarding the competence of graduates of the Faculty of Economics UNJ. 92.8% of alumni of the Faculty of Economics working as employees of the company, 5.8 % be a teacher, others go to college and as entrepreneurs . The average waiting time for alumni FE UNJ only takes waited less than 6 months to get a job. The level of salary received at the time of the first alumni of work varies with an average of 2-3 million by 49 % and between 3 million and above by 23 % . The level of compliance competencies and job average amounted to 77 % of alumni and competence of alumni based on the user 's perception was expressed by 71 % of alumni FE UNJ have a good competence.

  8. A teoria da pessoa de Tim Ingold: mudança ou continuidade nas representações ocidentais e nos conceitos antropológicos?

    Directory of Open Access Journals (Sweden)

    Regina Coeli Machado e Silva

    2011-06-01

    Full Text Available O objetivo deste artigo é discutir a proposta analítica de Tim Ingold para compreender a noção de pessoa, que pretende superar a dualidade mente/corpo. Essa dualidade é "repensada" através da objeção ao conceito de "representação coletiva", em favor de uma abordagem que incorpora elementos biológicos na explicação, concebendo a noção de pessoa como um aspecto da vida orgânica. O argumento aqui desenvolvido é que a incorporação desses princípios como uma tentativa de superar o dualismo mente/corpo nos obriga a enfrentar de modo renovado as questões aí colocadas, mas questiona se o resultado não seria reiterar explicações das propostas analíticas que quer refutar. Isto é, a base epistemológica da escola sociológica francesa que postula o fundamento social da cognição. Para isso, este artigo está organizado em três partes. A primeira, introdutória, apresenta o contexto social recente e o desenvolvimento das ciências cognitivas como condições propiciadoras da retomada do tema em questão. A segunda apresenta a perspectiva analítica de Ingold para compreender a noção de pessoa que, ao mesmo tempo, pretende ultrapassar dualismos como natureza e cultura, mente e corpo. Finalmente, na terceira parte, discute as implicações teóricas e ideológicas do argumento analítico proposto por IngoldThe aim of this paper is to discuss the analytical proposition of Tim Ingold in understanding the notion of Person who wants to overcome the duality of mind and body. This duality is "rethought" through the objection to the concept of "collective representation", in favor of an approach that incorporates biological principles in explaining, to conceive the person as an aspect of organic life in general. The argument developed here is that the incorporation of these principles as an attempt to overcome the mind / body dualism forces us to confront the issues in a new way. And it also questions whether the result would not renew

  9. U.S. Tsunami Information technology (TIM) Modernization:Developing a Maintainable and Extensible Open Source Earthquake and Tsunami Warning System

    Science.gov (United States)

    Hellman, S. B.; Lisowski, S.; Baker, B.; Hagerty, M.; Lomax, A.; Leifer, J. M.; Thies, D. A.; Schnackenberg, A.; Barrows, J.

    2015-12-01

    Tsunami Information technology Modernization (TIM) is a National Oceanic and Atmospheric Administration (NOAA) project to update and standardize the earthquake and tsunami monitoring systems currently employed at the U.S. Tsunami Warning Centers in Ewa Beach, Hawaii (PTWC) and Palmer, Alaska (NTWC). While this project was funded by NOAA to solve a specific problem, the requirements that the delivered system be both open source and easily maintainable have resulted in the creation of a variety of open source (OS) software packages. The open source software is now complete and this is a presentation of the OS Software that has been funded by NOAA for benefit of the entire seismic community. The design architecture comprises three distinct components: (1) The user interface, (2) The real-time data acquisition and processing system and (3) The scientific algorithm library. The system follows a modular design with loose coupling between components. We now identify the major project constituents. The user interface, CAVE, is written in Java and is compatible with the existing National Weather Service (NWS) open source graphical system AWIPS. The selected real-time seismic acquisition and processing system is open source SeisComp3 (sc3). The seismic library (libseismic) contains numerous custom written and wrapped open source seismic algorithms (e.g., ML/mb/Ms/Mwp, mantle magnitude (Mm), w-phase moment tensor, bodywave moment tensor, finite-fault inversion, array processing). The seismic library is organized in a way (function naming and usage) that will be familiar to users of Matlab. The seismic library extends sc3 so that it can be called by the real-time system, but it can also be driven and tested outside of sc3, for example, by ObsPy or Earthworm. To unify the three principal components we have developed a flexible and lightweight communication layer called SeismoEdex.

  10. Precise determination of δ88Sr in rocks, minerals, and waters by double-spike TIMS: A powerful tool in the study of chemical, geologic, hydrologic and biologic processes

    Science.gov (United States)

    Neymark, Leonid A.; Premo, Wayne R.; Mel'nikov, Nikolay N.; Emsbo, Poul

    2014-01-01

    We present strontium isotopic (88Sr/86Sr and 87Sr/86Sr) results obtained by 87Sr–84Sr double spike thermal ionization mass-spectrometry (DS-TIMS) for several standards as well as natural water samples and mineral samples of abiogenic and biogenic origin. The detailed data reduction algorithm and a user-friendly Sr-specific stand-alone computer program used for the spike calibration and the data reduction are also presented. Accuracy and precision of our δ88Sr measurements, calculated as permil (‰) deviations from the NIST SRM-987 standard, were evaluated by analyzing the NASS-6 seawater standard, which yielded δ88Sr = 0.378 ± 0.009‰. The first DS-TIMS data for the NIST SRM-607 potassium feldspar standard and for several US Geological Survey carbonate, phosphate, and silicate standards (EN-1, MAPS-4, MAPS-5, G-3, BCR-2, and BHVO-2) are also reported. Data obtained during this work for Sr-bearing solids and natural waters show a range of δ88Sr values of about 2.4‰, the widest observed so far in terrestrial materials. This range is easily resolvable analytically because the demonstrated external error (±SD, standard deviation) for measured δ88Sr values is typically ≤0.02‰. It is shown that the “true” 87Sr/86Sr value obtained by the DS-TIMS or any other external normalization method combines radiogenic and mass-dependent mass-fractionation effects, which cannot be separated. Therefore, the “true” 87Sr/86Sr and the δ87Sr parameter derived from it are not useful isotope tracers. Data presented in this paper for a wide range of naturally occurring sample types demonstrate the potential of the δ88Sr isotope tracer in combination with the traditional radiogenic 87Sr/86Sr tracer for studying a variety of biological, hydrological, and geological processes.

  11. La traducción al español de The Undercover Economist de Tim Harford: Consecuencias comerciales de la reducción de costes de traducción

    OpenAIRE

    Gutiérrez de las Heras, Marina

    2014-01-01

    [SP] Siempre se alude a la invisibilidad del traductor como un recinto del que este solo ha de salir si es para reforzar la calidad de su producto. Pero, ¿qué pasa cuando es precisamente la traducción la que entorpece la lectura? El economista camuflado, del economista Tim Harford, es un libro que pretende acercar la economía a personas legas en la materia. Está publicado por el Grupo Planeta y traducido por la agencia argentina Redactores en Red y se considera un superventas de la literatura...

  12. Interim Results from a Study of the Impacts of Tin (II) Based Mercury Treatment in a Small Stream Ecosystem: Tims Branch, Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Looney, Brian [Savannah River National Laboratory (SRNL); BryanJr., Larry [Savannah River Ecology Laboratory; Mathews, Teresa J [ORNL; Peterson, Mark J [ORNL; Roy, W Kelly [ORNL; Jett, Robert T [ORNL; Smith, John G [ORNL

    2012-03-01

    A research team is assessing the impacts of an innovative mercury treatment system in Tims Branch, a small southeastern stream. The treatment system, installed in 2007, reduces and removes inorganic mercury from water using tin(II) (stannous) chloride addition followed by air stripping. The system results in discharge of inorganic tin to the ecosystem. This screening study is based on historical information combined with measurements of contaminant concentrations in water, fish, sediment, biofilms and invertebrates. Initial mercury data indicate that first few years of mercury treatment resulted in a significant decrease in mercury concentration in an upper trophic level fish, redfin pickerel, at all sampling locations in the impacted reach. For example, the whole body mercury concentration in redfin pickerel collected from the most impacted pond decreased approximately 72% between 2006 (pre-treatment) and 2010 (post-treatment). Over this same period, mercury concentrations in the fillet of redfin pickerel in this pond were estimated to have decreased from approximately 1.45 {micro}g/g (wet weight basis) to 0.45 {micro}g/g - a decrease from 4.8x to 1.5x the current EPA guideline concentration for mercury in fillet (0.3 {micro}g/g). Thermodynamic modeling, scanning electron microscopy, and other sampling data for tin suggest that particulate tin (IV) oxides are a significant geochemical species entering the ecosystem with elevated levels of tin measured in surficial sediments and biofilms. Detectable increases in tin in sediments and biofilms extended approximately 3km from the discharge location. Tin oxides are recalcitrant solids that are relatively non-toxic and resistant to dissolution. Work continues to develop and validate methods to analyze total tin in the collected biota samples. In general, the interim results of this screening study suggest that the treatment process has performed as predicted and that the concentration of mercury in upper trophic level

  13. PENGARUH IKLIM ORGANISASI TERHADAP KINERJA KARYAWAN LEVEL PELAKSANA DI DIVISI OPERASI PT. PUSRI PALEMBANG

    Directory of Open Access Journals (Sweden)

    Kiki Cahaya Setiawan

    2016-05-01

    Full Text Available This study aims to determine influence of organizational climate on the performance of operational-level employees in the Operations Division of PT. Pusri Palembang. Operational-level employees in doing their jobs, will interact with various conditions of working environment. Working environment in the Operations Division PT. Pusri Palembang will be perceived by employees in operational-level as organizational climate. With sampling technique of proportional random sampling and using path analysis to analyse the data. The sample of this research covers 250 operational-level employees. Conclude that there was significant influence on the performance of organizational climate  of operational-level employees in the operations division of PT. Pusri Palembang. Based on  the findings in this study, it is necessary to create a pleasant organizational climate for Operational-level employees.if this dimension can be created  in companies that can maintain and improve the performance of operational -level employees.

  14. Pengaruh Gaya Kepemimpinan Kepala Ruangan Terhadap Kinerja Perawat Pelaksana di Rumah Sakit Provinsi Sumatera Utara

    OpenAIRE

    Zebua, Oktoberius

    2014-01-01

    Hospital as one of the health care facility has strategic role in their effort to accelerate the improvement of health of Indonesian. The nursing profession is one component of which is regarded as the key to the success of service delivery in the hospital. Successful leader is a leader who adjusts their leadership style to the organization he leads, the ability to set high goals to be achieved, the willingness and ability to take responsibility for the task, relevant education, experience, v...

  15. Thieme Textbook Internal Medicine - TIM

    International Nuclear Information System (INIS)

    Flasnoecker, M.

    1999-01-01

    The textbook and reference work covers the entire field of internal medicine arranged in 15 chapters, each covering a particular branch of internal medicine. This subject arrangement corresponds to the subject clusters of the regime of post-graduate education. Every branch, i. e. every chapter, has its own responsible editor. This selection of editors and authors,- all in all 180 experts in general and clinical practice -, guarantees a maximum of competence and compliance with the frontiers of research and clinical experience. (orig./CB) [de

  16. INTERIM RESULTS FROM A STUDY OF THE IMPACTS OF TIN(II) BASED MERCURY TREATMENT IN A SMALL STREAM ECOSYSTEM: TIMS BRANCH, SAVANNAH RIVER SITE

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Bryan, L.; Mathews, T.

    2012-03-30

    source control measures have resulted in rapid responses in lake or reservoir fisheries (Joslin 1994, Turner and Southworth 1999; Orihel et al., 2007), but examples of similar responses in Hg-contaminated stream ecosystems are less common. Recent work suggests that stream systems may actually be more susceptible to mercury bioaccumulation than lakes, highlighting the need to better understand the ecological drivers of mercury bioaccumulation in stream-dwelling fish (Chasar et al. 2009, Ward et al. 2010). In the present study we examine the response of fish to remedial actions in Tims Branch, a point-source contaminated stream on the Department of Energy's (DOE) Savannah River Site in Aiken, South Carolina. This second order stream received inorganic mercury inputs at its headwaters from the 1950s-2000s which contaminated the water, sediments, and biota downstream. In 2007, an innovative mercury removal system using tin (II) chloride (stannous chloride, SnCl{sub 2}) was implemented at a pre-existing air stripper. Tin(II) reduces dissolved Hg (II) to Hg (0), which is removed by the air stripper. During this process, tin(II) is oxidized to tin (IV) which is expected to precipitate as colloidal tin(IV) oxides and hydroxides, particulate materials with relatively low toxicity (Hallas and Cooney, 1981, EPA 2002, ATSDR, 2005). The objectives of the present research are to provide an initial assessment of the net impacts of the tin(II) based mercury treatment on key biota and to document the distribution and fate of inorganic tin in this small stream ecosystem after the first several years of operating a full scale system. To support these objectives, we collected fish, sediment, water, invertebrates, and biofilm samples from Tims Branch to quantify the general behavior and accumulation patterns for mercury and tin in the ecosystem and to determine if the treatment process has resulted in: (1) a measurable beneficial impact on (i.e., decrease of) mercury concentration in

  17. Penilaian Dosen dan Fakultas dalam Persepsi Mahasiswa Fakultas Ekonomi Unmas Denpasar

    OpenAIRE

    Novitasari, Ni Luh Gde; Merawati, Luh Komang

    2015-01-01

    Nowadays Indonesia has been entering a new competitive era which changing very fast especially on facing AFTA year 2015. It is neccessary to improving the quality of human resources in order to gain more competitive advantages by improving the quality of education process in college. This study was a preliminary research to determine students' perception related to assessment of lectures and Economic Faculty of Mahasaraswati University Denpasar. The respondents were 331 students from Economic...

  18. Analisis Komparatif Pelayanan Akademik Pada Fakultas Ekonomi Dan Fakultas ISIP Universitas Jenderal Achmad Yani

    Directory of Open Access Journals (Sweden)

    Nita Yura Roslina

    2015-10-01

    Full Text Available Upgrading of skills as well as knowledge to make a new generation of high quality to be able to pursue and develop science and technology are regarded as a catalyst of economic progress that will improve people's welfare. Therefore, the college has an ethical responsibility to the quality of its graduates as work ability, creativity, community recognition as an absorber of human resources towards credibility. Private universities are faced with tight competition and should do anticipate to explore and improve all aspects of service that are owned, including in terms of academic services. Academic services can be interpreted as an attempt by the college to provide facilities to meet the needs of students in matters related to academic activities. This study aims to find out, observe, assess and analyze whether there are significant differences anatara academic services students of the Faculty of Economics and the Faculty of Social and Political Sciences University General Achmad Yani. In this study took a sample of 149 students of the Faculty of Economics and 143 students from the Faculty of Social and Political Sciences Unjani.The method of analysis used to answer the hypothesis is to use parametric statistics that comparative analysis with t test (t-test. The results of his research is the average score of students of the Faculty of Economics Unjani to attribute academic services at 73.7% (relatively high compared to the average score of students of the Faculty of Social and Political Sciences of the attributes of academic services amounted to 72.6% (high enough. The difference score of 1.2% illustrate the difference. Results of calculation with the formula t-test separated sample variance relation is independent (uncorrelated and the second variant sample is not homogeneous, known F count larger than F table (1.3> 1,271. Based on calculations by comparing t arithmetic with t table known that t t table amounted to -1.79 -0.7047 with a standard error of 7.5% (0.075, thus there are significant differences on the attributes of academic services between the students of the Faculty of Economics with the students of the Faculty of Social Sciences and Political University General Achmad Yani.

  19. Zircon and allanite U-Pb ID-TIMS ages of vaugnerites from the Calzadilla pluton, Salamanca (Spain): dating mantle-derived magmatism and post-magmatic subsolidus overprint

    International Nuclear Information System (INIS)

    López-Moro, F.J.; Romer, R. L.; López-Plaza, M.; González Sánchez, M.

    2017-01-01

    Basic to intermediate high-K, high-Mg mantle-derived rocks occur throughout the Iberian Massif and are particularly important in the Tormes Dome, where vaugnerites form several stocks and small plutons. One of the largest and geochemically most variable among these plutons is the Calzadilla pluton in the Tormes Dome that crystallized at 318 ± 1.4Ma (Bashkirian; U-Pb TIMS zircon). This age reveals that the vaugnerite pluton was emplaced during the transition from late D2 extensional deformation to early D3 contractional deformation (319 to 317Ma). Large-scale extension in the area resulted, on one hand, in extensive anatexis in the crust due to quasiisothermal decompression and mica-dehydration melting and, on the other hand, in the upwelling of the mantle, which induced partial melting of the enriched domains in the lithospheric mantle. The driving reason why crustal and mantle melts were coeval is extension. The U-Pb ID-TIMS age of allanite is not related to the emplacement nor cooling of the Calzadilla vaugnerite, but it seems to be related to a younger subsolidus overprint ca. 275Ma that, in the scale of the Central Iberian Zone, corresponds to a period of hydrothermal alteration, including episyenite formation and tungsten mineralization.

  20. Zircon and allanite U-Pb ID-TIMS ages of vaugnerites from the Calzadilla pluton, Salamanca (Spain): dating mantle-derived magmatism and post-magmatic subsolidus overprint

    Energy Technology Data Exchange (ETDEWEB)

    López-Moro, F.J.; Romer, R. L.; López-Plaza, M.; González Sánchez, M.

    2017-07-01

    Basic to intermediate high-K, high-Mg mantle-derived rocks occur throughout the Iberian Massif and are particularly important in the Tormes Dome, where vaugnerites form several stocks and small plutons. One of the largest and geochemically most variable among these plutons is the Calzadilla pluton in the Tormes Dome that crystallized at 318 ± 1.4Ma (Bashkirian; U-Pb TIMS zircon). This age reveals that the vaugnerite pluton was emplaced during the transition from late D2 extensional deformation to early D3 contractional deformation (319 to 317Ma). Large-scale extension in the area resulted, on one hand, in extensive anatexis in the crust due to quasiisothermal decompression and mica-dehydration melting and, on the other hand, in the upwelling of the mantle, which induced partial melting of the enriched domains in the lithospheric mantle. The driving reason why crustal and mantle melts were coeval is extension. The U-Pb ID-TIMS age of allanite is not related to the emplacement nor cooling of the Calzadilla vaugnerite, but it seems to be related to a younger subsolidus overprint ca. 275Ma that, in the scale of the Central Iberian Zone, corresponds to a period of hydrothermal alteration, including episyenite formation and tungsten mineralization.

  1. Time evolution of a rifted continental arc: Integrated ID-TIMS and LA-ICPMS study of magmatic zircons from the Eastern Srednogorie, Bulgaria

    Science.gov (United States)

    Georgiev, S.; von Quadt, A.; Heinrich, C. A.; Peytcheva, I.; Marchev, P.

    2012-12-01

    Eastern Srednogorie in Bulgaria is the widest segment of an extensive magmatic arc that formed by convergence of Africa and Europe during Mesozoic to Tertiary times. Northward subduction of the Tethys Ocean beneath Europe in the Late Cretaceous gave rise to a broad range of basaltic to more evolved magmas with locally associated Cu-Au mineralization along this arc. We used U-Pb geochronology of single zircons to constrain the temporal evolution of the Upper Cretaceous magmatism and the age of basement rocks through which the magmas were emplaced in this arc segment. High precision isotope dilution-thermal ionization mass spectrometry (ID-TIMS) was combined with laser ablation-inductively coupled plasma mass spectrometry (LA-ICPMS) for spatial resolution within single zircon grains. Three tectono-magmatic regions are distinguished from north to south within Eastern Srednogorie: East Balkan, Yambol-Burgas and Strandzha. Late Cretaceous magmatic activity started at ~ 92 Ma in the northernmost East Balkan region, based on stratigraphic evidence and limited geochronology, with the emplacement of minor shallow intrusions and volcanic rocks onto pre-Cretaceous basement. In the southernmost Strandzha region, magmatism was initiated at ~ 86 Ma with emplacement of gabbroic to dioritic intrusions and related dikes into metamorphic basement rocks that have previously been overprinted by Jurassic-Lower Cretaceous metamorphism. The Yambol-Burgas region is an extensional basin between the East Balkan and the Strandzha regions, which broadens and deepens toward the Black Sea further east and is filled with a thick pile of marine sediments and submarine extrusive volcanic rocks accompanied by coeval intrusions. This dominantly mafic magmatism in the intermediate Yambol-Burgas region commenced at ~ 81 Ma and produced large volumes of potassium-rich magma until ~ 78 Ma. These shoshonitic to ultrapotassic basaltic to intermediate magmas formed by differentiation of ankaramitic (high

  2. A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.

    Directory of Open Access Journals (Sweden)

    Bridgette Janine Connell

    Full Text Available Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that IND02, a type A procyanidin polyphenol extracted from cinnamon, that features trimeric and pentameric forms displays an anti-HIV-1 activity against CXCR4 and CCR5 viruses with 1-7 μM ED50 for the trimer. Competition experiments, using a surface plasmon resonance-based binding assay, revealed that IND02 inhibited envelope binding to CD4 and heparan sulphate (HS as well as to an antibody (mAb 17b directed against the gp120 co-receptor binding site with an IC50 in the low μM range. IND02 has thus the remarkable property of simultaneously blocking gp120 binding to its major host cell surface counterparts. Additionally, the IND02-trimer impeded up-regulation of the inhibitory receptors Tim-3 and PD-1 on CD4+ and CD8+ cells, thereby demonstrating its beneficial effect by limiting T cell exhaustion. Among naturally derived products significantly inhibiting HIV-1, the IND02-trimer is the first component demonstrating an entry inhibition property through binding to the viral envelope glycoprotein. These data suggest that cinnamon, a widely consumed spice, could represent a novel and promising candidate for a cost-effective, natural entry inhibitor for HIV-1 which can also down-modulate T cell exhaustion markers Tim-3 and PD-1.

  3. Improved 206Pb/238U microprobe geochronology by the monitoring of a trace-element-related matrix effect; SHRIMP, ID-TIMS, ELA-ICP-MS and oxygen isotope documentation for a series of zircon standards

    Science.gov (United States)

    Black, L.P.; Kamo, S.L.; Allen, C.M.; Davis, D.W.; Aleinikoff, J.N.; Valley, J.W.; Mundil, R.; Campbell, I.H.; Korsch, R.J.; Williams, I.S.; Foudoulis, C.

    2004-01-01

    Precise isotope dilution-thermal ionisation mass spectrometry (ID-TIMS) documentation is given for two new Palaeozoic zircon standards (TEMORA 2 and R33). These data, in combination with results for previously documented standards (AS3, SL13, QGNG and TEMORA 1), provide the basis for a detailed investigation of inconsistencies in 206Pb/238U ages measured by microprobe. Although these ages are normally consistent between any two standards, their relative age offsets are often different from those established by ID-TIMS. This is true for both sensitive high-resolution ion-microprobe (SHRIMP) and excimer laser ablation-inductively coupled plasma-mass spectrometry (ELA-ICP-MS) dating, although the age offsets are in the opposite sense for the two techniques. Various factors have been investigated for possible correlations with age bias, in an attempt to resolve why the accuracy of the method is worse than the indicated precision. Crystallographic orientation, position on the grain-mount and oxygen isotopic composition are unrelated to the bias. There are, however, striking correlations between the 206Pb/238U age offsets and P, Sm and, most particularly, Nd abundances in the zircons. Although these are not believed to be the primary cause of this apparent matrix effect, they indicate that ionisation of 206Pb/238U is influenced, at least in part, by a combination of trace elements. Nd is sufficiently representative of the controlling trace elements that it provides a quantitative means of correcting for the microprobe age bias. This approach has the potential to reduce age biases associated with different techniques, different instrumentation and different standards within and between laboratories. Crown Copyright ?? 2004 Published by Elsevier B.V. All rights reserved.

  4. Timing of metamorphism and exhumation in the Nordøyane ultra-high-pressure domain, Western Gneiss Region, Norway: New constraints from complementary CA-ID-TIMS and LA-MC-ICP-MS geochronology

    Science.gov (United States)

    Butler, J. P.; Jamieson, R. A.; Dunning, G. R.; Pecha, M. E.; Robinson, P.; Steenkamp, H. M.

    2018-06-01

    We present the results of a combined CA-ID-TIMS and LA-MC-ICP-MS U-Pb geochronology study of zircon and associated rutile and titanite from the Nordøyane ultra-high-pressure (UHP) domain in the Western Gneiss Region (WGR) of Norway. The dated samples include 4 eclogite bodies, 2 host-rock migmatites, and 2 cross-cutting pegmatites and leucosomes, all from the island of Harøya. Zircon from a coesite eclogite yielded an age of ca. 413 Ma, interpreted as the time of UHP metamorphism in this sample. Zircon data from the other eclogite bodies yielded metamorphic ages of ca. 413 Ma, 407 Ma, and 406 Ma; zircon trace-element data associated with 413 Ma and 407 Ma ages are consistent with eclogite-facies crystallization. In all of the eclogites, U-Pb dates from zircon cores, interpreted as the times of protolith crystallization, range from ca. 1680-1586 Ma, consistent with Gothian ages from orthogneisses in Nordøyane and elsewhere in the WGR. A zircon core age of ca. 943 Ma from one sample agrees with Sveconorwegian ages of felsic gneisses and pegmatites in the western part of the area. Migmatites hosting the eclogite bodies yielded zircon core ages of ca. 1657-1591 Ma and rim ages of ca. 395-392 Ma, interpreted as the times of Gothian protolith formation and Scandian partial melt crystallization, respectively. Pegmatite in an eclogite boudin neck yielded a crystallization age of ca. 388 Ma, interpreted as the time of melt crystallization. Rutile and titanite from 3 samples (an eclogite and two migmatites) yielded concordant ID-TIMS ages of 378-376 Ma. The results are similar to existing U-Pb data from other Nordøyane eclogites (415-405 Ma). In combination with previous pressure-temperature data from the coesite eclogite, these ages indicate that peak metamorphic conditions of 3 GPa/760 °C were reached ca. 413 Ma, followed by decompression to 1 GPa/810 °C by ca. 397 Ma and cooling below ca. 600 °C by ca. 375 Ma. The results are compatible with protracted UHP

  5. Peran Unit Pelaksana Teknis (Upt) Industri Kulit Dan Produk Kulit Magetan Dalam Pemberdayaan Penyamak Kulit Di Kabupaten Magetan

    OpenAIRE

    purwanto, sofia rizky; astuti, puji; astrika, lusia

    2016-01-01

    Tanning industry is one of the regional potential in Magetan which has existed since the end of the Diponegoro War (± 1830), the tanning industry have helped support the leather industry. But in the years 1960-1970 the tanning industry has declined and nearly died because they were unable to compete with the plastics industry. To cope the situation the Local Government Magetan . UPT Industry Leather and Leather Products Magetan aims to build through the empowerment to the tanners, either thro...

  6. Gambaran Komunikasi Interpersonal Perawat Pelaksana Menurut Persepsi Perawat dan Klien di Ruang Rawat Inap RSUD Dr. Pirngadi Medan

    OpenAIRE

    Harahap, Dini Angriani

    2015-01-01

    Communication is a means to develop the relationship between nurses and clients. It is very important effective in facilitating nurses to carry out the role and function properly. Interpersonal communication is a communication between two or more people in direct contact like a conversation. This kind of communication is done face to face with two way method or reciprocal, either verbal or non-verbal. The research used descriptive design which was aimed to find out the description of interper...

  7. Revitalisasi Mahasiswa Fakultas Dakwah dan Komunikasi dalam Islamic Civilazation

    Directory of Open Access Journals (Sweden)

    Richway Richway

    2016-12-01

    Full Text Available Abstrak: Faculty of Dakwah and Communication UIN Raden Fatah Palembang constitute a valuable asset in creating propaganda resources to keep the Islamic Civilization. But the conditions of the students of the Faculty of Dakwah now showing symptoms of pragmatism. Most of them just put the value of academic and forget the obligations and responsibilities as a volunteer custodian of Islamic Civilization in the community. Critical thinking skills in addressing any problems in society increasingly minimal. Hence the need for mental revitalization and strategy in delivering propaganda in society. Hone back critical thinking skills and the ability to write expected to answer the social problems caused by various factors. This effort is expected to also not just limited discourse, but no real steps from the Faculty of Dakwah itself to the revitalization of mental and propaganda strategy.

  8. Evaluasi Prestasi Belajar Mahasiswa Fakultas Teknik Universitas Negeri Yogyakarta

    Directory of Open Access Journals (Sweden)

    Imam Muchoyar

    2013-09-01

    Full Text Available The objectives of this study are: (1 to identify the subjects that have low scores contributing to the low grade point average (GPA of the students and (2 to evaluate the reasons for the low academic achievement among the students. This study was conducted from May 2012 until September 2012. It was an evaluation study.The method used in this study was a comparative descriptive, by comparing the students’ GPA and the categories of the students’ achievement based on the Academic Regulations of Yogyakarta State University. In addition, the study also qualitatively compared the subjects in the departments which have low achievement. The population were all active students of Faculty of Engineering, YSU in the academic year of 2011/2012 who have scores of  below B in more than 3 courses. To evaluate the students who had low GPA, it is used purposive random sampling. The method of data collection used documentation, interviews and questionnaires. The data was analysed using qualitative and quantitative descriptive analysis. The conclusions of this study were: (1 the subjects of the fields study had a very dominant contribution to low GPA of the students. The percentages of the field of study subjects having low achievement in bachelor and associate degree programmes were  84.2% and 87.7% respectively; (2 The reasons  for low achievement of the students  based on the students ‘point of view were: (a the learning implementation aspects, especially from the lecturers (unclear teaching and explanation, inappropriate materials, excessive tasks and homework, the assessment process, (b tight schedule  and (c the intrinsic factors of the students. The reasons based on lecturers ‘point of view were: (a the students’ input (low motivation, low quality, laziness, and (b inadequate learning facilities both in terms of quantity and quality.

  9. Perancangan Sistem Informasi Data Alumni Fakultas Teknik Unsrat Berbasis Web

    OpenAIRE

    Watung, Ivan Arifard; Sinsuw, Alicia A. E

    2014-01-01

    Information technology has become the primary choice in creating an information system that can provide accurate and precise information. Backround of alumni data information system that is still manual data processing. The purpose of this system is to design a web-based information system. System design using the waterfall method comprising steps Information System Engineering, Requirements Analysis, Design, Coding, Testing, and Maintenance. Modeling using Flowmap or Flowchart, Context Diagr...

  10. EMPATI DAN PEMAAFAN PADA MAHASISWA FAKULTAS PSIKOLOGI UIN SUSKA RIAU

    Directory of Open Access Journals (Sweden)

    Dwi Indra Lestari

    2016-10-01

    Full Text Available Forgiveness has one important in human interpersonal relation.The purpose of this study was to examine the relationship between empathy and forgiveness on undergraduate student. The participants undergraduate student were 309 (47: men, 262, women from faculty of Psychology UIN Suska Riau.  This research used two kinds of scale, empathy  and forgiveness scale.The result showed: there is a significant and positive correlation  between empathy and forgiveness.. The  Implication of this result are discussed on the interpersonal relation contexts.

  11. CERN LHC Technical Infrastructure Monitoring (TIM)

    CERN Document Server

    Epting, U; Martini, R; Sollander, P; Bartolomé, R; Vercoutter, B; Morodo-Testa, M C

    1999-01-01

    The CERN Large Hadron Collider (LHC) will start to deliver particles to its experiments in the year 2005. However, all the primary services such as electricity, cooling, ventilation, safety systems and others such as vacuum and cryogenics will be commissioned gradually between 2001 and 2005. This technical infrastructure will be controlled using industrial control systems, which have either already been purchased from specialized companies or are currently being put together for tender. This paper discusses the overall architecture and interfaces that will be used by the CERN Technical Control Room (TCR) to monitor the technical services at CERN and those of the LHC and its experiments. The issue of coherently integrating existing and future control systems over a period of five years with constantly evolving technology is addressed. The paper also summarizes the functionality of all the tools needed by the control room such as alarm reporting, data logging systems, man machine interfaces and the console mana...

  12. Negovalni tim in komunikacija v zdravstveni negi

    OpenAIRE

    Balažic, Ignac

    2012-01-01

    V magistrskem delu smo predstavili psihodinamične elemente komuniciranja posameznika in dinamiko negovalnega tima. Opisane so določene komunikacijske veščine, ki so potrebne za uspešno medsebojno sodelovanje. Namen je ugotoviti ali se medicinske sestre v psihiatrični zdravstveni negi zavedajo pomena komunikacije za profesionalno delo v zdravstveni negi. Prav tako je namen ugotoviti, kako medicinske sestre in zdravstveni tehniki ocenjujejo komunikacijo na oddelku. Raziskovalna metodologija...

  13. Physics Conference TIM-15-16

    CERN Document Server

    2016-01-01

    The Conference is organized by the West University of Timisoara, Faculty of Physics. The scientific program of the conference will include invited lectures, oral and poster presentations, as well as discussions on various topics of present interest, such as, but not limited to condensed matter physics and applications, theoretical and computational physics, and applied physics.

  14. Un TIM verde para el POT

    OpenAIRE

    Duque Escobar, Gonzalo

    2014-01-01

    Manizales, que tampoco escapa a los problemas causados por la proliferación de carros y motos, y la congestión vehicular, debe integrar dos objetivos al POT: más transporte público colectivo y masivo, y mas ciclovías y rutas peatonales para viajes no motorizados

  15. A Waterman's Journey: Tim Junkin's Bloodsworth

    Science.gov (United States)

    Ward, Nathan

    2004-01-01

    Before he was wrongly sent to death row for the rape and murder of a nine-year-old girl in 1984, Kirk Bloodsworth enjoyed the life of a Chesapeake Bay waterman. Convicted largely on the testimony of a seven- and a ten-year-old eyewitness, by 1989 Johnson had exhausted almost every legal option available--after winning a new trial, he was convicted…

  16. Pengaruh Struktur Organisasi Terhadapkomunikasi dalam Tim Audit

    OpenAIRE

    Muhammad, Rifqi

    2009-01-01

    Some audit researchers suggest that high levels of audit team structure may encumber communication within audit teams by impeding information-gathering activities. Others suggest that structure benefits communication by coordinating controlling information flows. This study evaluated these arguments by examining the relationship between the structure of audit teams and selected communication variables (information overload, boundary spanning, satisfaction with supervision, and accuracy of inf...

  17. Plutarque, Sur l' E de Delphes 390 B 6-8 et l'explication de  la vision en Timée 45 b-d*

    Directory of Open Access Journals (Sweden)

    Alain Lernould

    2005-04-01

    Full Text Available Le traité (ou dialogue « pythique » du platonicien Plutarque de Chéronée (Iier – IIe s. ap. J.-C. intitulé Sur l’E de Delphes est consacré à l’élucidation de la signification de l’E (la cinquième lettre de l’alphabet grec consacré à Apollon Pythien. Une des interprétations (d’inspiration pythagoricienne est que cet E désigne le nombre cinq, le nombre de l’univers. Dans le cadre de l’exposé de cette interprétation est fait état de l’opinion « de certains » selon laquelle il existe une correspondance entre les cinq sens et les cinq éléments. L’A. montre que les deux lignes où il est question de la vue (E 390b6-8 s’inspirent essentiellement de l’explication qu’en Timée 45b-d Platon donne du mécanisme de la vision en termes de mélange du feu pur émis par l’œil avec le feu pur extérieur qui produit la lumière du jour. L’extrême brièveté de ce résumé (empreint d’aristotélisme, l’élément associé à la vue étant ici l’éther considéré comme cinquième corps, d’un passage dans Platon offrant lui-même bon nombre de difficultés, explique que ces deux lignes énigmatiques n’aient jamais été bien comprises. Au passage, l’A. revient sur les notions d’homoiopatheia (d’homogénéité et de summetria (de commensurabilité en Timée 45b-d et 67c-e pour en proposer une interprétation qui souligne et éclaire d’un jour nouveau le caractère dynamique de l’explication platonicienne de la vision. Un Appendice donne un aperçu des différentes lectures d’E 390b6-8 depuis les premières éditions imprimées à la Renaissance jusqu’aux éditions critiques des 19e et 20e siècles.The essay (or dialogue On the E at Delphi of the Platonist Plutarch of Chaeronea (c. 50 – c. 125 A.D. is devoted to the elucidation of the mysterious E – the fifth letter of the Greek alphabet – that is dedicated to Apollo. According to one interpretation the E is, in a Pythagorean

  18. Isotope age of the rare metal pegmatite formation in the Kolmozero-Voron'ya greenstone belt (Kola region of the Fennoscandian shield): U-Pb (TIMS) microlite and tourmaline dating

    Science.gov (United States)

    Kudryashov, Nikolay; Lyalina, Ludmila; Mokrushin, Artem; Zozulya, Dmitry; Groshev, Nikolay; Steshenko, Ekaterina; Kunakkuzin, Evgeniy

    2016-04-01

    The Kolmozero-Voron'ya greenstone belt is located in the central suture zone, which separates the Murmansk block from the Central-Kola and the Keivy blocks. The belt is represented by volcano-sedimentary rocks of Archaean age of 2.9-2.5 Ga. Rare metal pegmatites (Li, Cs with accessory Nb, Ta, and Be) occur among amphibolite and gabbroid intrusions in the northwestern and southeastern parts of the belt. According to the Rb-Sr data, the age of pegmatites was considered to be 2.7 Ga. Until recently there was no generally accepted point of view on the origin of pegmatites. Now we have isotopic data for a range of rock complexes that could pretend to be parental granites for the rare metal pegmatites. These are granodiorites with the zircon age of 2733±Ma, and microcline and tourmaline granites, which Pb-Pb isochronal age on tourmaline from the tourmaline granite located near the deposit is estimated to be 2520±70 Ma. The pegmatite field of the Vasin Myl'k deposit with the lepidolite--albite--microcline--spodumene--pollucite association is located among amphibolites in the northwestern part of the belt. The deposit is represented by subparallel low-angle zoned veins up to 220 m long and 5 m thick dipping in the southeastern direction at an angle of 10° too 30°. The minerals of the columbite--tonalite group from Vasin Myl'k deposit include microlite, simpsonite, and torolite, and are the oldest among different minerals represented by several generations in pegmatites under consideration. Zircons from the pegmatites are mostly represented by crystals with the structure affected by the action of fluids that put certain restrictions on its use as a geochronometer of the crystallization process. Microlite from the pegmatite taken from the dump of a prospecting drill hole was used for U--Pb (TIMS). The mineral is represented by 0.5--1.0 mm long euhedral octahedral crystals. It is brown in color, and transparent. The microlite crystals were preliminarily cleaned from

  19. Individualized Education Program (IEP Mata Pelajaran Kimia untuk Siswa Slow Learner

    Directory of Open Access Journals (Sweden)

    Rovik Rovik

    2017-06-01

    [Siswa slow learner menempati populasi tertinggi untuk siswa berkebutuhan khusus. Sebagai salah satu jenis learning disability, slow learner masih dapat belajar dengan teman sebayanya asalkan guru mempersiapkan program pembelajaran khusus yang telah dimodifikasi dari pembelajaran reguler. Program ini disebut Individualized Education Program (IEP. Penelitian ini mencoba mengembangkan IEP mata pelajaran kimia untuk slow learner, mengidentifikasi komponen yang dibutuhkan dalam menyusun IEP untuk slow learner, dan menganalisis judgement reviewers (guru kimia dan guru pendamping khusus dan peer reviewers terhadap IEP yang dikembangkan. Hasil penelitian menunjukkan slow learner membutuhkan IEP sebagai dokumen utama panduan guru dalam pembelajaran kimia di kelas. Komponen pengembangan IEP meliputi identitas peserta didik, tim pengembangan dan pelaksana, asesmen yang pernah dilakukan, hambatan dan kekuatan, kebutuhan dan perlakuan, faktor pendukung dan penghambat, rencana perlakuan, dan modifikasi terhadap perangkat pembelajaran kimia reguler

  20. Faktor-Faktor Penyebab Stres Kerja Pada Guru Kelas Autis di Unit Pelaksana Teknis SLB-E Negeri Pembina Tingkat Provinsi Tahun 2016

    OpenAIRE

    Mawardika, Risa

    2016-01-01

    Occupational stress is an individual reaction such as physiologist reaction, psychologist and behavior toward stress or every condition of occupational which is perception as work’s demand that can influence worker productivity. This can be influence for autism class teachers, they are different from the other teachers, in general. Here, those teachers have to be more patient on facing their students. To educate autism children is a hard work which parents and teachers must do, this is will b...

  1. Perbedaan Pengaruh Imbalan Jasa yang dipersepsikan oleh Perawat Pelaksana dalam Memberikan Asuhan Keperawatan di RSUP H. Adam Malik Medan dan RSU Martha Friska Medan

    OpenAIRE

    Stefani, Elisabeth

    2011-01-01

    The nurse executive who worked as an employee/employees in private or government agencies would expect to earn income or remuneration sufficient to meet the most basic or primary. Such behavior can be explained because of the high rate of return will increase the level of employee motivation in work. The purpose of this study to determine the difference effect of fees on performance perceived by the nurse executive in providing nursing care to H. Adam Malik Hospital and Martha Friska Hospital...

  2. Pengembangan Model Kompetensi Kepemimpinan Kepala Ruang Sebagai Upaya Peningkatan Motivasi Dan Kinerja Perawat Pelaksana (Studi Kasus: Rumah Sakit Umum Daerah Kota Mataram, Nusa Tenggara Barat)

    OpenAIRE

    SUDARIANI, PUTU WIDHI

    2016-01-01

    Introduction: Leadership competencies are unsuitable that given the leadership to employees, can decrease the motivation, performance and ultimately job satisfaction. This research was conducted to develop a leadership competency model as an effort to improve the motivation and performance of nurses so as to improve health services. Methods: This research have two phase, phase one is analytic observational with 140 sample, analysis data with partial least square (PLS), formulation of strategi...

  3. Hubungan Antara Karakteristik Perawat dengan Motivasi Perawat Pelaksana dalam Menerapkan Komunikasi Terapeutik Pada Fase Kerja Di Rumah Sakit Islam Sultan Agung Semarang

    Directory of Open Access Journals (Sweden)

    Ali Roatib

    2007-07-01

    Full Text Available The nursing service in a hospital is a major part of the health service given to the clients. Thus, the quality of the health service is extremely determined by the quality of the nursing service and it’s influenced by the nurse effectively in giving the nursing treatment to the clients. The importance of the nurse in guiding the trust relationship to the clients through a therapeutic communication is useful as a support in establishing the nursing treatment, in order that it can be recognized what is being required by the clients.The research want to know the relationship between the characteristic and the motivation of the performer nurse in applying therapeutic communication of working phase, by considering the nurse characteristic of the age side, sex, education, the long-term work and training. This research used correlative descriptive design using cross sectional. This research took samples of the performer nurse in Islamic Hospital Sultan Agung Semarang to 47 people using a technique of simple random sampling. The data were collected by utilizing questioner filled by the respondents.The result of univariat analysis indicates that the nurse motivation in Islamic Hospital Sultan Agung Semarang is in a high category (80,9%. While, bivariate analysis is recognized that the nurse characteristic has a significant correlation with the nurse motivation in applying therapeutic communication of working phase, that is, to the education dimension with significance 0,000, to the training dimension with significance 0,000, to the age dimension with significance 0,021, to the long-term work dimension with significance 0,034, however, there is a variable statistically not having a meaning relationship namely to the sex dimension with significance 0,135.

  4. Pengaruh Quality of Work Life terhadap Kinerja Perawat Pelaksana di Rumah Sakit Tk II Putri Hijau Kesdam I/BB Medan

    OpenAIRE

    Pratama, Muchti Yuda

    2012-01-01

    Quality of work life is a problem which should have been paid attention by the management of Level II Putri Hijau Hospital Kesdam I/BB Medan because quality of work life is regarded as being able to improve the participation and contribution of the nurses working here to this hospital. The purpose of this analytical survey study with cross-sectional design conducted at Level II Putri Hijau Hospital Kesdam I/BB Medan was to analyze the influence of quality of work life including employees’ ...

  5. Workplace Spirituality Tenaga Kependidikan Universitas Brawijaya (Studi Pada Fakultas Ilmu Pengetahuan Alam Dan Matematika Serta Fakultas Ilmu Sosial dan Ilmu Politik

    Directory of Open Access Journals (Sweden)

    Sutan Rachman WHS

    2014-12-01

    Full Text Available Konsep pengembangan manusia secara menyeluruh merupakan solusi atas perubahan fenomena sosial saat ini yang menyebabkan kehidupan seseorang tidak menyatu karena lingkungan pekerjaan atau tempat kerja hanya menjadi tempat untuk mencari hal-hal profan (duniawi dan tidak mempunyai ruang untuk sesuatu yang sakral atau suci. Akibat dari adanya pemisahan ini, seseorang lebih terfokus hidupnya untuk menggeluti dunia karir tanpa memperhatikan kehidupan batinnya. Fenomena tersebut menumbuhkan kesadaran untuk menghubungkan aspek spiritualitas individu dengan pengelolaan pekerjaan  atau lingkungan kerja, melalui konsep workplace spirituality,. Dalam studi akademis, workplace spirituality merupakan bidang yang masih baru dan masih terus dikembangkan, namun sebagian besar studi masih dilakukan di Amerika Serikat dan Kanada, dan sangat sedikit sekali yang dilakukan di luar kedua negara tersebut. Berdasarkan hal itu, penelitian ini bermaksud untuk memperkaya topik workplace spirituality dari sudut pandang administrator publik di Indonesia melalui pendekatan fenomenologi, dengan menggunakan metode kualitatif, penelitian ini menghasilkan dua sudut pandang terkait workplace spirituality, pertama adalah sudut pandang agama dan yang kedua adalah sudut pandang intrinsik  -  alamiah, kedua sudut pandang tersebut sama – sama bertujan untuk memberikan makna dalam bentuk ekspresi positif dalam lingkungan kerja. Penelitian lebih jauh juga dibutuhkan untuk memperkokoh konsep ini, baik melalui metode kualitatif maupun kuantitatif.Kata kunci: Agama, Perilaku, Spiritual, Tuhan, Workplace Spirituality,

  6. PENGARUH KOMUNIKASI, MOTIVASI, DAN KERJASAMA TIM TERHADAP PENINGKATAN KINERJA KARYAWAN

    Directory of Open Access Journals (Sweden)

    Eva Silvani Lawasi

    2017-08-01

    Full Text Available The purpose of this study are : (1 to know and analyze the influence of communication, motivation, and team cooperation on employee performance. (2 to know and analyze the variable that has dominant influence to employee performance. The data obtained in this study is the primary data by distributing questionnaires to the respondents. Analyzed data uses multiple linear regression model.. The results of this study proves that, (1 communication has a positive and a significant affect on the improvement of employee performance. (2 Motivation has a positive and a significant affect to the improvement of employee performance. (3 Team cooperation doesn�t have a significant affect to the improvement of employee performance and (4 Communication has the dominant influence in improving employee performance. Keywords: Communication, motivation, teamwork, employee performance�

  7. Peran Tim Bidang Kedokteran Gigi dalam Pelayanan Geriatri Terpadu

    Directory of Open Access Journals (Sweden)

    Tri Budi W. Rahardjo

    2015-09-01

    Full Text Available The characteristic of geriatric problems are multiple, interdependent, and chronic diseases, in which mastication is significant in affecting general health condition among the elderly. In this regard, the role of dental team in integrated geriatric services is highly needed. The number of dentists and various disciplines in dentistry will depend on the level of health facilities. The role dentists will be important both in "Day Hospital" or in the geriatric wards, as members of the team who will involve in the process of services since diagnostic stage until the follow up treatment. In addition, the dental team will also be able to solve the geriatric problems, in promotion/prevention program as well as home visit.

  8. Inovasi Manajemen Pelayanan Publik Tim Emergency Service Kabupaten Bantaeng

    OpenAIRE

    Tamimi, Zindar

    2015-01-01

    Bantaeng an area that small territory, small population, small local revenues, frequent natural disasters, and frequent cases of fatal such as maternal mortality. To overcome this situation Local Government made Emergency Service Team. Emergency Service Teams provide services in new ways, namely by finding and serving the community in a proactive and integrated. This study uses exploratif qualitative method. Data collection techniques in research using interviews, observation, and documentati...

  9. Tim Ingold and Jo Lee Vergunst, eds., . Aldershot, Ashgate ...

    African Journals Online (AJOL)

    ANBR

    gatherers; her ethnographic descriptions are ... (averaging two weeks per. Ways of walking: Ethnography and practice on foot. Department of Anthropology. Rhodes University. Grahamstown. South Africa content process. 191. BOOK REVIEWS. 0. 5. 25.

  10. Pengaruh Kultur Kantor Akuntan Publik terhadap Komunikasi dalam Tim Audit

    Directory of Open Access Journals (Sweden)

    Peni Nugraheni

    2016-02-01

    Full Text Available This research examines the effect of the Public Accountant Firm (KAP culture in audit team communication. The samples used in this study is accountant publics ever or joining in audit team for certain duty with working experience between three up to five years in the KAP audit division. The samples consist of 118 accountant publics from 50 KAP in 8 cities at Java Island and Bali. The proxies for KAP culture are bureaucracy, inovatif and suportif culture. The result indicate that bureaucracy and suportif culture significantly influence the audit team communication. The  result have implication to KAP about how to create the right culture to support the success of audit team communication in resulting a quality audit opinion.

  11. Disney skandaalne juht kindel oma strateegia õiges valikus / Tim Burt

    Index Scriptorium Estoniae

    Burt, Tim

    2004-01-01

    Viimase kümne kuu jooksul on ettevõte Walt Disney üle elanud tormid firma juhatuses, 58 miljardi dollarilise ülevõtmisekatse, avalikud kokkupõrked partneritega ning aktsionäride mässu, mis sundis Michael Eisnerit loovutama ettevõtte juhatuse esimehe ja tegevjuhi ametikohad. Lisad: Konflikt; Walt Disney

  12. Reflecting on 10 Years of the TIM Review

    Directory of Open Access Journals (Sweden)

    Chris McPhee

    2017-07-01

    Full Text Available In July 2007, the first issue of this journal was published under the banner of the Open Source Business Resource. Re-launched with a broader scope in 2011 as the Technology Innovation Management Review, the journal now celebrates its 10th anniversary. In this article, we review the 10-year history of the journal to examine what themes have been covered, who has contributed, and how much the articles have been read and cited. During those 10 years, the journal has published 120 monthly issues, including more than 800 publications by more than 800 international authors from industry, academia, the public sector, and beyond. As discovered with topic modelling, the journal has covered seven themes: open source business, technology entrepreneurship, growing a business, research approaches, social innovation, living labs, and cybersecurity. Overall, the website has attracted over 1 million readers from around the world – 31% from Asia, 30% from the Americas, 26% from Europe, 8% from Africa, and 5% from Oceania – with over 25,000 readers now accessing the site each month.

  13. Kofi Annan und Tim Berners-lee preisen Informationsfreiheit

    CERN Document Server

    Ermet, Monika

    2003-01-01

    The UN General Secretary and the Pioneer of WEB, will participate in Geneva at the WSIS with scholars from all the world. The World Summit on the Information Society was held in two phases. The first phase took place in Geneva hosted by the Government of Switzerland from 10 to 12 December 2003. It addressed the broad range of themes concerning the Information Society and adopted a Declaration of Principles and Plan of Action

  14. Estimating unsaturated hydraulic conductivity from soil moisture-tim function

    International Nuclear Information System (INIS)

    El Gendy, R.W.

    2002-01-01

    The unsaturated hydraulic conductivity for soil can be estimated from o(t) function, and the dimensionless soil water content parameter (Se)Se (β - βr)/ (φ - θ)), where θ, is the soil water content at any time (from soil moisture depletion curve l; θ is the residual water content and θ, is the total soil porosity (equals saturation point). Se can be represented as a time function (Se = a t b ), where t, is the measurement time and (a and b) are the regression constants. The recommended equation in this method is given by

  15. The year of evolution for 2002 / Tim Ferland

    Index Scriptorium Estoniae

    Ferland, Tim

    2003-01-01

    Eesti-Ameerika Kaubandus-Tööstuskoja liikmed on esimese tegutsemisaastaga rahul. Aktiivselt osaleti NATO Baltimaadesse laienemise diskussioonides. Lisa: Eesti sai kutse ühineda NATO-ga 21. novembril 2002

  16. Targeting Tim-1 to Circumvent Immune Tolerance in Prostate Cancer

    Science.gov (United States)

    2012-09-01

    responses to PSA self- antigen in transgenic mice. Prostate 70:1002. 7. Koh, Y. T., A. Gray, S. A. Higgins, B. Hubby, and W. M. Kast . 2009. Androgen...15766662] 14. Koh YT, Gray A, Higgins SA, Hubby B, Kast WM. Androgen ablation augments prostate cancer vaccine immunogenicity only when applied after...Mercader M, Bodner BK, Moser MT, Kwon PS, Park ES, Manecke RG, Ellis TM, Wojcik EM, Yang D, Flanigan RC, Waters WB, Kast WM, Kwon ED. T cell

  17. Sex, snakes and violence / Sherwin Das, Tim Ochser

    Index Scriptorium Estoniae

    Das, Sherwin

    2006-01-01

    Patrick Süskindi krimiromaani "Parfüüm" ekraniseering "Perfume: The Story of a Murderer" : režissöör Tom Tykver : Ameerika Ühendriigid - Saksamaa 2006. Õuduspõnevik "Maod lennukis" ("Snakes on a Plane") : režissöör David R. Ellis : Ameerika Ühendriigid 2006

  18. Percolation Phenomena For New Magnetic Composites And Tim Nanocomposites Materials

    Directory of Open Access Journals (Sweden)

    Ahmed Thabet Mohamed

    2015-01-01

    Full Text Available This paper presents a theoretical investigation in order to obtain new composite and nanocomposite magnetic industrial materials. The effective conductivity and thermal effective conductivity have been predicted by adding various types and percentages of conductive particles (Al2O3, MgO, ZnO, Graphite etc. to the main matrices of Epoxy, Iron and Silicon for formulating new composite and nanocomposite industrial materials. The characterization of effective conductivity of new polymeric composites has been investigated with various applied forces, inclusion types and their concentrations. In addition, the effect of inclusion types and their concentrations on the effective thermal conductivities of thermal interface nanocomposite industrial materials has been explained and discussed.

  19. Hubungan Antara Lingkungan Kerja Dan Kerjasama Tim Dengan Kepuasan Kerja

    OpenAIRE

    Oktapiani, Marliza

    2011-01-01

    The Objectivity of study is to examine the work Environment and Teamwork in improving to lecture's job satisfaction teacher's at Raudhatul Athfal of Duren Sawit region east Jakarta. In this study, the method applied is descriptive quantitative method. Analysis unit refers lecture's job satisfaction at Raudhatul Athfal of Duren Sawit region east Jakarta . Instrument applied in collecting of data it is questioner.This study covers: (1) is the work Environment lecture's job satisfaction teacher'...

  20. HUBUNGAN ANTARA LINGKUNGAN KERJA DAN KERJASAMA TIM DENGAN KEPUASAN KERJA

    OpenAIRE

    Oktapiani, Marliza

    2011-01-01

    The Objectivity of study is to examine the work Environment and Teamwork in improving to lecture's job satisfaction teacher's at Raudhatul Athfal of Duren Sawit region east Jakarta. In this study, the method applied is descriptive quantitative method. Analysis unit refers lecture's job satisfaction at Raudhatul Athfal of Duren Sawit region east Jakarta . Instrument applied in collecting of data it is questioner.This study covers: (1) is the work Environment lecture's job satisfaction teacher'...

  1. TIM Series: Theory, Evidence and the Pragmatic Manager

    Directory of Open Access Journals (Sweden)

    Steven Muegge

    2008-08-01

    Full Text Available On July 2, 2008, Steven Muegge from Carleton University delivered a presentation entitled "Theory, Evidence and the Pragmatic Manager". This section provides the key messages from the lecture. The scope of this lecture spanned several topics, including management decision making, forecasting and its limitations, the psychology of expertise, and the management of innovation.

  2. Pengaruh Kultur Kantor Akuntan Publik Terhadap Komunikasi Dalam Tim Audit

    OpenAIRE

    Nugraheni, Peni

    2005-01-01

    This research examines the effect of the Public Accountant Firm (KAP) culture in audit team communication. The samples used in this study is accountant publics ever or joining in audit team for certain duty with working experience between three up to five years in the KAP audit division. The samples consist of 118 accountant publics from 50 KAP in 8 cities at Java Island and Bali. The proxies for KAP culture are bureaucracy, inovatif and suportif culture. The result indicate that bureaucracy ...

  3. ISOLASI DAN KARAKTERISASI PROTEASE ALKALIN DARI ISOLAT BAKTERI LIMBAH TERNAK DI EXFARM FAKULTAS PETERNAKAN UNSOED

    Directory of Open Access Journals (Sweden)

    Zusfahair

    2011-05-01

    Full Text Available Protease is one of the widely used enzymes for the industry. The potential resource of microorganism that produced protease is milk cow waste. In this research, isolation and characterization has been done toward isolated protease from milk cow waste of the Exfarm’s Animal Husbandry Faculty at University of Jenderal Soedirman, Purwokerto. The research used experiment method and the parameters observed were the genus of bacteria which produce protease and the activity of protease. The characterizations of protease were determination of optimum pH and temperature, the influence of metal ions, EDTA, surfactant, and commercial detergent toward enzyme activity, and also the study of enzyme stability. The results from the research showed that the isolated bacteria from the Exfarm’s of Animal Husbandry Faculty of UNSOED, which produced protease was Salmonella sp. Characterization of isolated Salmonella sp. from 45% ammonium sulphate fraction indicated that the optimum temperature was 50 ºC, optimum pH was 8, the enzyme was activated by Ca2+ dan Mg2+ ion, whereas it was inhibited by Zn2+, Cu2+ ions and EDTA. The addition of Tween-80 with the concentration of 0.2% and 0.4% increased protease activity, however the addition of Tween-80 with concentration higher than 0.6% decreased the protease activity. Enzyme protease from isolated Salmonella sp. was relatively stable with the addition of commercial detergent such as Attack, Surf, and Bukrim.

  4. Hubungan Self Assessment-Peer Assessment dengan Nilai Kelulusan OSCE Mahasiswa Fakultas Kedokteran Unisba

    Directory of Open Access Journals (Sweden)

    Santun Bhekti Rahimah

    2017-02-01

    Full Text Available Abstrak Objective structured clinical examination (OSCE adalah cara penilaian kompetensi klinik mahasiswa secara komprehensif dan konsisten serta dapat dijadikan media untuk meningkatkan hasil belajar. Feedback dapat dilakukan oleh mahasiswa itu sendiri (self assessment maupun mahasiswa lain yang satu level (peer assessment. Self dan peer assessment diharapkan akan meningkatkan kemampuan mahasiswa dalam melihat tujuan pembelajaran, meningkatkan rasa percaya diri, kemampuan berpikir kritis, dan bertindak tepat dalam menghadapi ujian. Tujuan penelitian ini melihat hubungan self assessment dan peer assessment dengan nilai kelulusan OSCE mahasiswa tingkat dua dan empat FK Unisba tahun akademik 2012/2013. Nilai hasil ujian OSCE yang dipergunakan adalah pada periode Desember 2012–Juni 2013. Self dan peer assessment dilaksanakan setelah ujian OSCE. Self assessment dilakukan oleh mahasiswa itu sendiri, sedangkan peer assessment didapatkan dari lima orang mahasiswa lain yang pernah berada dalam satu kelompok dengan subjek. Hasil penelitian menunjukkan untuk mahasiswa tingkat dua terdapat korelasi bermakna self assessment dan peer assessment dengan nilai OSCE (p<0,001, arah hubungan antara keduanya positif, serta kekuatan hubungan keduanya sedang (R=0,426. Pada mahasiswa tingkat empat terdapat korelasi bermakna antara self assessment dan nilai OSCE (p<0,001 dengan kekuatan hubungan keduanya sedang (R=0,451, serta terdapat korelasi yang bermakna antara penilaian peer assessment dan nilai OSCE. Simpulan, self assessment mempunyai korelasi positif terhadap nilai kelulusan OSCE pada mahasiswa tingkat dua dan tingkat empat, sedangkan peer assessment mempunyai korelasi positif dengan nilai kelulusan OSCE hanya pada mahasiswa tingkat dua. Self assessment mempunyai korelasi positif dengan peer assessment pada mahasiswa tingkat dua dan tingkat empat FK Unisba tahun akademik 2012/2013. Abstract Objective structured clinical examination (OSCE is a tools to assess  students clinical competency comprehensively and consistently. It can also used as medium to improve the learning process. Feedback for student performance can be done trough self-assessment or peer assessment done by other students. Self and peer assessment are expected to enhance the ability of students to see the purpose of learning, improve self-confidence, the ability to think critically and act right in an examination. The aim of this study was to find the relationship between self assessment and peer assessment of the OSCE final mark of second and fourth grade student at Medical Faculty, Bandung Islamic University academic year 2012/2013. The OSCE mark used were taken from December 2012–June 2013, while the self and peer assessment carried out after the OSCE finished. Self assessment were done by students themselves, while peer assessment obtained from five persons which have been in one group with subject. Results showed that for second grade student showed there was significant correlation between self-assessment and peer assessment and OSCE's mark value (p<0.001 with the direction of the relationship was positive and had moderate strength (R=0.426. Fourth grade students showed significant correlation only between self-assessment and OSCE's mark value (p<0.001 with moderate strength (R=0.451. There was no significant relation between the assessment of peer assessment and OSCE's mark value. In clonclusion, self assessment correlated positively to OSCE's mark value for second and fourth grade students. Peer assessment correlated positively to the passing scores for second grade student. Self assessment had a positive correlation to peer assessment for second and fourth grade medical students.

  5. SURVEI KEPUASAN MAHASISWA TERHADAP KUALITAS PELAYANAN PROGRAM STUDI PSIKOLOGI ISLAM FAKULTAS PSIKOLOGI UIN RADEN FATAH PALEMBANG

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    Listya Istiningtyas

    2018-02-01

    Full Text Available The approach used is a quantitative approach. The type of research is descriptive survey research, which uses the questionnaire as an instrument of data collection. The questionnaire used consisted of two types of questionnaires, namely self-identity questionnaire and satisfaction questionnaire on service quality. The satisfaction questionnaire is divided into 3 sections: teaching and learning process, administration process and student facility. Data collection was done by spreading the questionnaire to the subject and collected 159 complete questionnaires. After the data entry using the computer program excel, conducted frequency calculation techniques to illustrate the effect of service quality parameters with the level of student satisfaction. Data were analyzed by quantitative descriptive technique then converted and summarized into qualitative conclusions. From the research result, it can be concluded that teaching-learning process and administration process in Islamic Psychology Study Program Faculty of Psychology has been satisfied, just for the provision of facilities still need to be improved such as lecture facilities, computers and internet. Islamic Psychology Study Program Faculty of Psychology has fulfilled most of student expectation. Suggestions given by the students to the Faculty of Psychology to be more advanced in the future related to the improvement of physical facilities, human resources, service and graduates competitiveness.

  6. Problematika Penyelesaian Proyek Akhir bagi Mahasiswa Program Diploma 3 Jurusan Teknik Otomotif Fakultas Teknik UNY

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    Tawardjono Tawardjono

    2010-05-01

    Full Text Available Penelitian ini bertujuan menemukan kesulitan-kesulitan mahasiswa dalam menyelesaikan proyek akhir (PA, yang meliputi: menentukan judul/topik, proses bimbingan, prosespengerjaan, menulis laporan, serta menemukan solusi permasalahannya.Penelitian ini termasuk penelitian deskriptif kualitatif. Populasi penelitian adalah mahasiswa yang telah dan sedang mengerjakan Proyek Akhir pada tahun perkuliahan 2009/2010 dan Dosen Pembimbing PA jurusan Teknik Otomotif. Teknik sampling menggunakan ’incidental sampling’ yang didapat 55 mahasiswa dan 15 dosen pembimbing. Teknik pengambilan data menggunakan kuesioner dan wawancara sebagai pelengkap. Teknik analisis data menggunakan analisis deskriptif kualitatif.Hasil penelitian menunjukkan bahwa: Kesulitan terbesar mahasiswa datang dari faktor internal, khususnya kejiwaan mereka yang meliputi aspek motivasi dan tanggung jawab mahasiswa menyelesaikan proyek akhir. Hambatan berikutnya berturut-turut: faktor instrumental, lingkungan dan kejasmanian; Hambatan mahasiswa dalam pelaksanaan Proyek Akhir adalah dalam menentukan judul, melakukan perhitungan dan pembuktian dan masalah plagiat. Solusi yang disampaikan adalah mahasiswa perlu memilih dan menentukan judul yang feasibel, menambah wawasan pengetahuan teknik dan aplikasi otomotif, melatih kreativitas dan inovasi, memperdalam materi metodologi dan proaktif terhadap kegiatan bimbingan, membuat jadwal penggunaan bengkel dan dosen pembimbing di bengkel.

  7. Jurusan Manajemen Fakultas Ekonomi Universitas Mataram JL. Majapahit No.62, Mataram, Nusa Tenggara Barat, 83125

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    I Nyoman Nugraha Ardana Putra

    2017-03-01

    Full Text Available This study aimed to examine and to explain the influence of managerial ownership and credit risks towardagency costs and performance. The study was also intended to enrich the empirical evidence of agency theory infinancial management of the Microfinance Institutions (MFIs, especially managerial ownership of society creditbank (BPR in West Nusa Tenggara province. Secondary data used was derived from financial statements andprimary data obtained from interviews with the director of bank samples. Partial Least Square technique Programs(PLS was applied to test the research model in term of variables relationship structure in quantitativemethods The results. The results showed that managerial ownership had a positive influence on credit risks andalso had a positive impact on agency costs. In addition to managerial ownership and agency costs, this researchfound that there was a negative effect of company performance.

  8. Gambaran Pengetahuan Mahasiswa/i Fakultas Kedokteran Universitas Sumatera Utara Stambuk 2008 - 2010 mengenai Buta Warna

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    Handayani, Elvina

    2011-01-01

    Color blindness is a condition where a person losses the ability to differentiate the colors, which can be differentiated by the normal vision one. Color blindness in a person mostly caused by genetic factor. Color blindness is generally considered to be more prevalent in men compared to women with a ratio of 20:1. According to the Health Research Association (RISKESDAS) 2007, the national prevalence of color blindness was 0.7% Aim of the research is to identify and to know the knowledge o...

  9. Hubungan Konsumsi Fast Food dengan Kadar Kolesterol pada mahasiswa di Fakultas Kedokteran USU tahun 2016

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    Lim, Frederick

    2017-01-01

    Background. Economic development and industrialization give a lot of influence on the diet of people, one of them is fast food. Fast food consumption is often associated with increased level of cholesterol. High cholesterol is a risk factor for degenerative diseases. Objectives. The aim of this study was to determine the association between the frequency of fast food consumption with total cholesterol levels in university students. Method. This study used a cross sectional design and to...

  10. Pengembangan Teknologi Informasi Mobile Learning Fakultas Teknik Universitas Diponegoro Berbasis Android

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    Resi Jiwa Kasatria

    2014-11-01

    Full Text Available Perkembangan teknologi mobile seluler sudah sedemikian cepat dan dapat dirasakan di seluruh dunia dan dimanfaatkan dalam berbagai bidang kehidupan. Perkembangan ini dapat pula dilakukan dalam dunia pendidikan dan memungkinkan terobosan baru dalam belajar secara mobile menggunakan perangkat teknologi informasi (handphone atau disebut mobile learning (m-learning. M-learning memiliki beberapa kelebihan di antaranya adalah independensi dalam pembelajaran. Namun, di sisi lain, perangkat pembelajaran m-learning memiliki keterbatasan sumber daya dan keragaman platform sehingga diperlukan rancangan yang mampu menjamin kompatibilitas. Aplikasi Mobile Learning ini dikembangkan menggunakan Java EE untuk menangani servernya dan untuk sisi klien menggunakan Bootstrap mobile. Basis data yang digunakan adalah MySQL. Aplikasi ini akan mempunyai 3 role pengguna yaitu admin yang akan menangani penambahan user dan pengelolaan mata kuliah, dosen yang akan memberikan materi, tugas dan kuis dan mahasiswa yang dapat melihat materi, tugas dan kuis yang diberikan dosen. Mobile Learning ini dapat membantu dosen dan mahasiswa dalam melakukan interaksi dalam berbagi materi, dalam pemberian tugas dan mengerjakan kuis. Mahasiswa maupun dosen tidak lagi harus bertatap muka, yang diperlukan hanyalah koneksi internet untuk melakukan proses belajar mengajar. Selain itu Mobile Learning ini juga dapat berjalan dengan baik saat diuji pada 3 buah versi android yang berbeda yaitu versi 2.3, versi 4.0 dan versi 4.2.

  11. PREDIKTOR KEBERHASILAN STUDI PADA MAHASISWA DI FAKULTAS PSIKOLOGI UIN SUNAN GUNUNG DJATI BANDUNG

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    Fenti Hikmawati

    2018-02-01

    Full Text Available This study will specifically investigate the personal factors of students, whether they are biographic, or suspected psychological effect on the success of studies in the faculty of Psychology. Demographic factors such as intelligence level factors, whether the school background of high school, vocational school, or MA, and majors of time in SMU / SMK / MA. These factors are investigated for allegedly influence the success of the study. If proven, empirically, the results of this study expected to be a consideration in the selection of new students of psychology faculty UIN Sunan Gunung Djati Bandung. During this selection system seems not yet to consider these factors. In fact, psychological test results of students' 2007-2008 force distribution of the IQ level of students was very varied between 78 to 115 points. Not much different school backgrounds and majors. The design of this study applying correlational design, multiple regression. With multiple regression, it is possible to forecast a variable based on the values of some predictors. The assumption by using several predictors will make more accurate predictions. In addition, with multiple regression is statistically possible to measure the influence of several predictor variables to control the other predictor variables (Blaikie, 2003. Research data, including: (1 The primary data is data related to emotional intelligence and social support, and (2 secondary data id data relating to the level of intelligence. Secondary data were obtained from laboratory psycho-tests held by the faculty of Psychology UIN SGD Bandung and the data contained in the faculty of Psychology UIN SGD Bandung. Results of data analysis shows that the correlation coefficient of the three independent variables with dependent variables for 0409 with a value of R2 of 0167. It shows that 16.7 percent of the variation of study success is determined by emotional intelligence, social support, and level of intelligence. Level intelligence backgrounds of students majoring in natural science majors were higher than social science or language. Meanwhile, 83.3 percent more determined by other variables.

  12. Penggunaan E-learning Ilmo untuk Meningkatkan Mutu Perkuliahan di Fakultas Ekonomi

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    Asrori, Asrori; Fachrurrozie, Fachrurrozie

    2011-01-01

    This study has objectives to examine empirically the behavior of teachers in accepting the use of e-Learning Ilmo (Learning Increasing Motivation) and ti improve the quality of lectures at Economic Faculty. The respondents of this research were lectures who were the users of e-Learning Ilmo. The data were collected through qustionnaire that was developed based on the construct of the theory of technology acceptance (Davis et al, 1989). The results of hypotheses testing were: (1) The usefulnes...

  13. Produksi Bahasa Tertulis Mahasiswa Penderita Disgrafia Di Fakultas Ilmu Budaya Universitas Sam Ratulangi

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    TANGKE, RIMA APRILIANA

    2015-01-01

    This research is entitled “Written Language Production of Student with Disgraphia in Faculty of Humanity Sam Ratulangi University”. The objectives of this research are to describe dysgraphia itself and to analyze the influences of dysgraphia on the written language production of the student in Faculty of Humanity, Sam Ratulangi University. This research uses a descriptive method. There are three steps to finish this research, the first step is preparation. In this step, the writer reads the r...

  14. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PRESTASI BELAJAR MAHASISWA FAKULTAS EKONOMI UNIVERSITAS NEGERI PADANG

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    vella anggresta anggresta

    2015-10-01

    Full Text Available This study aimed to analyze and see the influence of factors influencing students’ achievement of Economical Faculty of Padang State University. This study was explorative study. The population was all of students majoring in S1 Economical Faculty of Padang State University; the total was 1546 students. In taking the sample, it was used the proportional random sampling with the total sample was 318 students. The data were analyzed by using descriptive analysis, factorial analysis, and regression analysis and the hypothesis was analyzed by using T-test. The result showed that (1 there were eight factors influence the students’ achievement such as (a teaching quality factors included lecturers’ creativity, lecturers’ understanding, facilities, learning references, and learning atmosphere in campus; (b independency factors included competitive atmosphere, taking initiative, teamwork, and study preparation; (c internal condition factors included living atmosphere, family relationship, and parents’ attention; (d ethic factors included learning motivation, learning effort, and ability to solve the problems; (e concentration variables included physic condition, tiredness, and learning variables; (f eating habit and achievement factors include eating and achievement to be succeed; (g supplement factors included learning atmosphere, financial condition and participation in learning; (h caring factors include how the parents treated the children. (2 the regression showed that the eating habit, achievement to be succeed and caring variables were not significantly influence toward students achievement.

  15. Analisis Iklim Mikro Kandang Domba Garut Sistem Tertutup Milik Fakultas Peternakan IPB

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    Meiske Widyarti

    2011-04-01

    Full Text Available Microclimate condition of cage affecting the growth of livestocks. Livestocks will be able to develop and grow optimally in a good cage condition. Cages indoor or microclimate should be comfort and fit for livestock growth and functioned as a protector from environment influences. A good microclimate condition is influenced by air temperature, moisture content, velocity of air flow, and intensity of light. This study aims to analyze the distribution of temperature, humidity, wind speed and patterns inside the Garut sheep’s cage. Datas are collected on Faculty of Animal Husbandry IPB’s Garut sheep fattening cages. Datas including temperature, relative humidity, wind speed, and solar radiation were taken three days from 07:00 pm until 15:00 pm and analyzed using microsof exel program. The study results showed that the highest indoor cage temperature is 33.330C at 12.00 pm., with relative humidity 73,33% and wind speed 0,38 m / sec. This condition is not optimal enough for Garut sheeps’s growth.

  16. Bagian Ilmu Kesehatan Gigi dan Mulut Fakultas Kedokteran Gigi Universitas Hasanuddin Makassar, Indonesia

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    Riskayanty Riskayanty

    2014-02-01

    Full Text Available Elderly people are particularly vulnerable to oral disease. Decreased function of the body can affect the aging process of the organic, and anorganic content in the elderly. The aim of this study was to determine the content of organic elements (total protein level, volume and pH of saliva in the elderly. This descriptive observational study with crosssectional design was performed in Tresna Werdha Gau Mabaji Social Institution, Gowa (n=30with a simple random sampling technique using 30% of the total population and in Werdha Theodora Makassar nursing home with saturated sampling technique (n = 13. Anorganic contents were measured using spectophotometric and organic content of the total protein level of saliva was measured using an autoanalyzer tool kyltec in BPTP Laboratory Maros. Statistical analysis was performed with t-test using SPSS version 16. There were no significant differences between the anorganic (Ca2+,Mg2+, and phosphate and organic elements content of saliva (total protein level, the volume of saliva and salivary pH in the elderly by sex and age groups. Yet, there are significant differences in the volume of saliva of elderly who consume drugs for systemic diseases. It is concluded that gender and age do not affect the anorganic (Ca,and phosphateand organic element content of saliva (total protein content, the volume of saliva, and saliva pH in the elderly. Drugs consumed for systemic diseases does not affect the anorganic and organic element content of saliva and the pH of saliva in the elderly.

  17. Bagian Ilmu Kesehatan Gigi dan Mulut Fakultas Kedokteran Gigi Universitas Hasanuddin Makassar, Indonesia

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    Riskayanty Riskayanty; Nurul Fitriani R. D; Rasmidar Samad

    2014-01-01

    Elderly people are particularly vulnerable to oral disease. Decreased function of the body can affect the aging process of the organic, and anorganic content in the elderly. The aim of this study was to determine the content of organic elements (total protein level), volume and pH of saliva in the elderly. This descriptive observational study with crosssectional design was performed in Tresna Werdha Gau Mabaji Social Institution, Gowa (n=30)with a simple random sampling technique using 30% of...

  18. Penerapan Program Microsoft Project 2010 untuk Perencanaan dan Pengendalian pada Pembangunan Gedung Serbaguna Fakultas Kedokteran

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    Santoso, Erick; Rafie; Wardhani, Nurul

    2014-01-01

    Banyak program komputer yang dikembangkan untuk membantu dalam bidang Teknik Sipil diantaranya Microsoft Project 2010yang dibuat oleh Microsoft. Program ini dapat membantu para manajemen proyek konstruksi dalam merencanakan suatu proyek dan mengontrol setiap pekerjaan yang dikerjakan.

  19. Pengaruh Senam Zumba Terhadap Kebugaran Kardiorespiratori Pada Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi Angkatan 2014

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    Gunawan, Andre; Polii, Hedison; Pengemanan, Damajanty H. C

    2015-01-01

    : Physical exercise is an attempt to keep the physical fitness. Zumba is a form of the implementation of HIIT's (High Intensity Interval Training) method ie cardio exercise done in a short time with high intensity. Cardiorespiratory fitness is the ability the heart and lungs to absorb and take advantage of oxygen during the exercise occurred. Cardiorespiratory fitness was assessed through VO2 max. The research is meant to know the effect of zumba to the cardiorespiratory fitness. This researc...

  20. Pengaruh Metode Belajar Jigsaw Terhadap Keterampilan Hubungan Interpersonal dan Kerjasama Kelompok pada Mahasiswa Fakultas Psikologi

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    Asmadi Alsa

    2015-11-01

    Full Text Available This study aims to test the effect of cooperative learning methods, the jigsaw method to interpersonal relationship skill and teamwork of undergraduate students Faculty of Psychology in University A. This study used experimental method with one group and pre posttest design. There are 63 undergraduate students in Educational Psychology Class of 2008/2009 as the subjects. The measurement instrument was Interpersonal Relationship Skill Scale and Teamwork Scale. Interpersonal relationship and teamwork score compared before and after the learning methods were given and tested using paired samples t test. The result shows that comparing the pretest and posttest score of interpersonal relationship variable, we got t ‐1,748 with p = 0,043 (p < 0,05. This is indicated that jigsaw learning method has significant effect to improving the interpersonal relationship skill in undergraduate students. The analysis result in teamwork variable with comparing the pretest and posttest, we got t ‐3,50 with p = 0,001 (p < 0,01 which means the jigsaw learning method significantly effective to improving teamwork skill in undergraduate student

  1. Pengaruh Latihan Tari Legong Terhadap Kebugaran Fisik Mahasiswi Semester VI dan VIII Fakultas Kedokteran Universitas Udayana

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    K. G. Budhi Riyanta

    2013-04-01

    Full Text Available Sport is a way to promote health and prevent degenerative diseases. Sport has great benefits in improving physical fitness and maintaining ideal body weight. This study found that the potentials of domestic culture can be used as a form of sports. Legong dance is one of popular Balinese tradisional art which has dynamic movements with duration of 20 minutes. A randomized pre-test and post-test contol group design was carried out to compare the effectiveness of the Balinese Legong dance with Senam Ayo Bersatu (one of aerobic dance in improving physical fitness and reducing body fat. Thirty samples who came from the sixth and eighth semester in the Faculty of Medicine Udayana University were divided into three different groups: I (Legong dance intervention, II (Senam Ayo Bersatu intervention, and control (without intervention. The intervention was done in 40 minutes for 8 weeks with three times intervention/week. Time of 2.4 km run as parameter of physical fitnees and body fat percentage was measured before starting the intervention and at last eighth weeks. It was elicited the significant difference (p?0.05 that Legong dance was more effective as Senam Ayo Bersatu in improving physical fitness and maintain body fat composition.

  2. Gambaran Pengetahuan, Sikap, dan Tindakan Donor Darah pada Mahasiswa Fakultas Kedokteran Universitas Tanjungpura Pontianak

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    Sabdiah Eka Sari

    2013-01-01

    Background. Mortality rate caused by the lack of blood supply wasincreased in development countries. The fact, blood donor percentage stilllow that caused restrictiveness to fill blood requirement that moreincreased. Restrictiveness amount of blood donor can caused by the lowof knowledge about blood donor, any wrong perception about blood donor,or the anxiety about blood donor procedure.Objective. To know description of knowledge, attitude, and blood donorpractice of college student at Medica...

  3. STUDI PENELUSURAN LULUSAN S1 KEPENDIDIKAN FAKULTAS TEKNIK UNIVERSITAS NEGERI YOGYAKARTA

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    Thomas Sukardi

    2015-02-01

    Full Text Available ABSTRACT This research aim at revealing: (1 graduate absorption from bachelor of education Faculty of Engineering, Yogyakarta State University (YSU in job market, (2 information of suitability of competence and job oppportunity, (3 feedback from graduates’ employer/ user, (4 opinion form the alumnae. This study can be catagorized as survey research which was conducted in September till November  2010. The research population was the graduates from the year of 2006 to 2012 and this study employed snowball technique as  data collection technique. The instrument of data collection were using open and closed questionnaire with online or offline process. The online procedure was through website of  http://ft.uny.ac.id/tracer, email of tracerftuny@gmail.com while the offline one was through sending letter. The qualitative data were analyzed by crosstab and percentage and the qualitative one was using categorial analysis.   The findings showed that (1 the graduates’absorption can be catagorized as good catagory, the waiting period for the graduates to get a job was less than 3 months with percentage of 52.8%, for period of 3-6 months was 23.1%, more than 12 months was 7.2% and not giving answer was 5.6%; (2 the students’ competence also catagorized as good catagory, but for supporting aspects such as managerial and leadership aspect still needed to be improved; (3 the feedback from graduates’ employers or users were in case of improving managerial ability, leadership aspect, foreign language competence, information technology skills, and soft skills (4 the suggestions from alumnae or the graduates of Faculty of Engineering YSU in order to develop graduates competence on education field were the separation between students community service and teaching practicum though it took in the same location of school,  enhancing the guidence process with the  lecturers such for scientific writing, enhancing the experience of teaching on the real context especially for the students with educational background, enhancing learning based multimedia, developing the curriculum which was suited with Vocational High School, and the teaching methodology also needed to be reviewed and improved. Keywords: bachelor of education, graduates absorption and graduates’tracer study

  4. Pengembangan Aplikasi Manajemen Pelatihan Laboratorium Software Engineering Di Fakultas Teknik Sistem Komputer

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    Faiz Risaludin Islami

    2016-04-01

    Full Text Available System computer engineering of Diponegoro University has a software engineering laboratory fonctioned to provide the learning and training activities in order to give the opportunity for the students, to examine and to apply the theory or the research and the verification scientifical subject study or a part of certain subject study. The probleme emerge in this training is less the information about the training accepted by the society who willing to attend the training at the software engineering laboratory. In propose, to solve all the problemes appear, the writer make a Management Trainee Developement Application System of Software Engineering Laboratory at Faculty of System Computer Engineering gave a complete information about the training and the registration in software engineering laboratory. Management Trainee Application of Software Engineering Laboratory at Faculty of System Computer Engineering is an application based on website, made by using the program language PHP in scope Framework Code Igniter, and also MySQL for database. The developement methode used the waterfall methode, while designing the application used the UML modele. The result from this application is the realization an application based on website which is abble to manage the trainee data in software engineering laboratory, for example to manage the participant training data, the list of training data, the time schedule training data, admin data, the participant traininh data along the completed training History data.

  5. Rancang Bangun Perpustakaan Digital Berbasis Document Management System pada Fakultas Ilmu Komputer UNSIKA

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    Yayan Gustiana

    2018-05-01

    Full Text Available A book is a reading tool for everyone, it is very important for an institution to keep knowledge going and generate new knowledge. In the library of the Faculty of Computer Science Unsika, one of the obstacles that is the library space where the books are less adequate and difficult to find the title of research for final students because the title should not be the same. Development of a library with Document Management System based is a method in solving the problem, it is expected to provide solutions in achieving a document management. Can accommodate all books uploaded by users, given permissions and speed in the deployment to all users. Development of this modeling tool using the method. Which is in accordance with the wishes of customers. Database storage using MySQL, Object Oriented Programming (OOP programming language using the Code Igniter (CI framework. Based on the results of simple random sampling of 35 respondents 86.80% say agree to the digital library. the concept of document management system required large storage media, server and good local connectivity. This function can also be a stepping stone to do research.

  6. Perancangan Website Departemen Kependudukan Dan Biostatistika, Fakultas Kesehatan Masyarakat Universitas Sumatera Utara

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    Nasution, Ari Fakhri

    2015-01-01

    The change of information through the internet become more popular lately. To an educational institution, like Department of Population and Biostatistics, it is such a challenge. Moreover, Department of Population and Biostatistics is one prime-movers of Faculty of Public Health. Educational institution may use the most effective and efficient way to communicate as a part of their education service. Website’s designing aims to make a change of information on Department of Population and Biost...

  7. Pengaruh Kompensasi dan Kepuasan Kerja terhadap Kinerja Dosen Fakultas Ilmu Tarbiyah dan Keguruan UIN Sunan Kalijaga

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    Rinduan Zain

    2017-05-01

    Full Text Available This quantitative research of the correlational model aims to analyze the influence of compensation (X1 and job satisfaction (X2 towards lecturers’ performance (Y while it is being controlled with organizational commitment (Z which is based on the theory of two factors proposed by Frederick Herzberg. The results of the comparison between bivariate correlation coefficient (X1 =compensation Y = compensation and lecturers’ performance and partial correlation coefficients (X = compensation, Z = organizational commitment, and Y = lecturers’ performance indicates that ryx1 > ryx1z i.e. 0317 > 0268. This means that the compensation affects lecturers’ performance which is mediated by the organizational commitment. The result of the regression proves the value of β1= 0.153 and β2= 0.383, in which compensation and commitment contribute to the enhancement of lecturers’ performance up to 54%. This signifies that once the lecturers are granted high amount of compensation and hold distinctive organizational commitment, then it will increase their performance up to 54%. Regarding job satisfaction, the result shows significant bivariate correlation (X2 = job satisfaction, and Y = lecturers’ performance i.e. 0.001 α 0.10 to be significant. Thus, indeed job satisfaction is in line with lecturers’ performance. Meanwhile, the regression shows that the job satisfaction regression coefficient (β is accounted for 0.267, in which job satisfaction contributes to the improvement of lecturers’ performance up to 27%. This suggests that lecturers with high level of job satisfaction are likely to increase their performance up to 27%, even though they do not hold organizational commitment

  8. Gambaran Kualitas Tidur pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Tahun Akademik 2013/2014

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    Fauzan, Rivhan

    2015-01-01

    People spend a third of their time to sleep which sleeping is an essential requirement for their life. The previous study in various countries reported high prevalence of poor sleep quality on medical student and can impact on their general health and academic performance. The aim of this study is to describe sleep quality on the students of the Faculty of Medicine USU academic year 2013/2014. This was a descriptive research method with a cross-sectional approach. Samplin...

  9. Peranan Penyesuaian Diri terhadap Stres Akibat Kemacetan pada Mahasiswa Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasin

    OpenAIRE

    Putri, Dwi Utami Madya; Anward, Hemy Heryati; Erlyani, Neka

    2016-01-01

    The objective of this study was to find out the role of self adjustment towards stress due to traffic jam on the students of Medical Faculty of Lambung Mangkurat University, Banjarmasin. The subjects in this study were selected using purposive sampling technique with the criteria that they were students of Medical Education Department of Medical Faculty of Lambung Mangkurat University Banjarmasin, batch 2013 as many as 51 students. The data collection method was a simple linear regression. Th...

  10. FAKTOR-FAKTOR YANG MEMPENGARUHI LITERASI FINANSIAL MAHASISWA FAKULTAS EKONOMI DAN BISNIS UNIVERSITAS BRAWIJAYA

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    Irin Widyawati

    2012-12-01

    Full Text Available The purpose of this study to clarify: (1 the influence of socio-economic status of parents towards education family financial management, (2 the influence of parental socioeconomic status on cognitive aspects of financial literacy, (3 the influence of parental socioeconomic status on financial literacy aspects of attitude, (4 the effect of family financial management education to the cognitive aspects of financial literacy, (5 the effect of family financial management education for financial literacy aspect of attitude, (6 the effect of learning in higher education to cognitive aspects of financial literacy, (7 the effect of learning college for financial literacy aspect of attitude; (8 the effect of socioeconomic status of parents of student cognitive aspects of financial literacy through education family financial management; (9 the influence of socio-economic status of parents towards financial literacy aspect of student attitudes through education family financial management . Data collected using tests and questionnaires from 220 students. Data analysis techniques in this study using path analysis. The results of the study are: (1 socio-economic status of parents significant positive direct effect on education family financial management, (2 socio-economic status of parents does not directly influence the cognitive aspects of financial literacy, (3 socio-economic status of parents do not have direct the financial literacy aspect of attitude, (4 education family financial management a significant positive direct effect on the cognitive aspects of financial literacy, (5 education family financial management a significant positive direct effect on financial literacy aspect of attitude, (6 learning in higher education have direct positive significant impact on the cognitive aspects of financial literacy, (7 learning in higher education have significant positive direct effect on financial literacy aspect of attitude; (8 socio-economic status of parents significantly positive indirect effect on the cognitive aspects of financial literacy education mediated by family financial management; (9 the socioeconomic status of parents significantly positive indirect effect on the financial literacy aspect of attitude that is mediated by a family financial management education.

  11. Literasi Informasi Pustakawan di Perpustakaan Fakultas Teknik UGM Menggunakan Pengembangan Model The BIG6

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    Yudistira Yudistira

    2017-06-01

    Full Text Available This research aims to know librarian literacy information in the Library of Faculty of Engineering UGM based on the big6 model and to know the stages of librarian literacy information in the Library of Faculty of Engineering UGM for each stage based on the big6 model. The method that the researchers use in this research is descriptive quantitative. This research is a population study, where the entire population is used as a research sample. The population in this research is all librarians in the Library Faculty of Engineering UGM which amounted to 4 people. Data analysis using mean & grand mean formula. Based on the data that has been processed it is known that librarian literacy information in the Library of Faculty of Engineering UGM belong to the category well proved with the grand mean value of 3.20. From the stages the definition of the problem is very good with a value of 3.28. From the stages of information search strategy, classified very well with a value of 3.27. From the stages of the location and access stage, it is very good with 3.38. From the stages of the use of information, quite well with the value of 2.88. From the synthesis stage, it is quite good with a value of 3.21. From the evaluation stage, it is good with 3.20. This research is expected to provide input to the library to maintain and improve skills in the field of information literacy.

  12. Analisis dan Desain Website Program Studi Administrasi Bisnis (Studi pada Fakultas Ilmu Administrasi Universitas Brawijaya Malang)

    OpenAIRE

    Alloni, Kevin Yudhistira; Riyadi, Riyadi; Dewantara, Rizki Yudhi

    2017-01-01

    This study aims to find the cause of the problem on the website of BASP FSA UB, find the reasons for the analysis and design of website, and to describe the analysis and design of BASP FSA UB website so the website becomes more informative, could create relationship with student, and help the service of Business Administration Study Program. This research is conducted in Business Administration Study Program Faculty of Administrative Science Universitas Brawijaya Malang, at Jalan Major Genera...

  13. Tingkat Resepsi Mahasiswa Fakultas Bahasa Dan Seni Universitas Negeri Yogyakarta Terhadap Budaya Eropa

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    Dian Swandayani

    2011-12-01

    Full Text Available Artikel ini bertujuan mendeskripsikan tingkat pemahaman dan tingkat apresiasi mahasiswa FBS UNY terhadap budaya Eropa pada awal abad ke-21. Subjek penelitian ini adalah mahasiswa FBS UNY yang terdiri atas sebelas program studi pada tahun ajaran 2010/2011. Objek penelitiannya adalah aspek-aspek budaya Eropa. Teknik pengumpulan datanya dengan tes dan angket. Teknik analisis datanya dilakukan secara deskriptif kuantitatif dan kualitatif. Hasil penelitian menunjukkan bahwa pemahaman mahasiswa FBS UNY terhadap budaya Eropa abad ke-21 hanya sebesar 22,0%, sedangkan tingkat apresiasinya sebesar 37,5%. Berdasarkan rata-rata, diperoleh angka tingkat pemahaman dan tingkat apresiasi tersebut hanya sebesar 29,75%. Berdasarkan kajian resepsi sastra, tingkat pencapaian tersebut dapat ditelusuri lebih lanjut faktor -faktor penyebabnya. Meskipun demikian, tingkat pemahaman dan apresiasi yang rendah tersebut diperlukan suatu usaha guna lebih mengenalkan budaya Eropa kepada mahasiswa FBS UNY melalui rancangan model dan modul pembelajaran. Model dan modul pembelajaran tersebut tidak hanya pada pengenalan budaya Eropa, tetapi juga dalam rangka mengukuhkan nasionalisme generasi muda Indonesia. Abstract: This article aims to describe the level of understanding and appreciating of students in the Language and Art Faculty, Yogyakarta State University, to European culture in the beginning of 21st century. Subject of this research are students of Language and Art Faculty YSU that consist of eleven study programs in 2010/2011 academic year. The object of this research is European culture’s aspect. The data were collected by test and questionnaire. The data were analyzed by quantitative and qualitative technique. The result of the research indicates that the understanding level of students in the Language and Art Faculty, YSU, to European culture in the beginning 21st century is just 22.0%. The appreciating level is 37.5%. In average, the level of understanding and appreciating is just only 29.75%. This level is low. According to literature reception, that achievement could be examined some factors caused. In other side, to increase this level, it needs some efforts like learning model and module to introduce more on European culture to student of Language and Art Faculty, YSU. Learning model and module is not only to introduce European culture, but also to strengthen nationalism for Indonesian young generation. Key Words: understanding level, appreciating level, European culture, sense of nationalism

  14. DUKUNGAN SOSIAL PADA MAHASISWA YANG SEDANG MENYUSUN SKRIPSI ( STUDI FENOMENOLOGIS PADA MAHASISWA FAKULTAS PSIKOLOGI UNDIP

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    Tri Puji Astuti

    2013-04-01

    Full Text Available As a mandatory part of an undergraduate degree in almost all universities, students are required to write their undergraduate thesis in order to receive their degree. It is not an easy job, because there are many challenges and problems while planning and writing their paper. Many students are quite frustrated and tensed as their degree depends on their final thesis submission. On the other hand, the process are not always cause the student become depresssed and fail. The condition is due to the support from the people around them. This study took a qualitative approach to explain that fenomena. The formalized question of the study is how the social support experiences impact the paper writing process. There are six (6 student of the Faculty of Psychology that participated in the study. Each respondent has a different experience with social support that they had received, and not all of them have a positive effect. Social support received by students from a variety of sources and different types of social support benefits more. Students who were interviewed stated that between parents and friends, have just as great a role but they have differences in the type of social support that fit with the students.

  15. Pengaruh Warna Ruang Kerja Terhadap Kenyamanan Dosen Departemen Psikologi Industri Dan Organisasi Fakultas Psikologi USU

    OpenAIRE

    Bangun, Eva Violesia

    2014-01-01

    Comfort in the work is desired by each worker and indirectlybecame an important predictor in the company's operational efficiencies such as productivity, job satisfaction, well-being, and safety. Creating a physical environment that is comfortable is one way to increase comfort in work and color is one of the factors that influence a comfortable working environment. Giving color combinations are paint the wall of workspace PIO with green color and add accessories to the room with purple color...

  16. Kajian Keselamatan dan Kesehatan Kerja Bengkel di Jurusan Pendidikan Teknik Sipil dan Perencanaan Fakultas Teknik Uny

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    Nur Hidayat

    2016-05-01

    Full Text Available The objective of this study was to analyse: (1 the plan (2 the implementation, and (3 the evaluation of the Occupational Safety and Health (OSH management in the workshop of the Department of Civil Engineering and Planning Education, Faculty of Engineering, Yogyakarta State University (YSU. This study was categorised into descriptive study that scientifically explained the workplace environment of the workshop specifically in terms of the OSH management. The data collection techniques used observations, interviews and questionnaires. The data of this study was analysed descriptively. This study presented the detailed descriptions of the collected data in the field. The results revealed (1 It is crucial to develop a more systematic OSH management plan in the workshop of the Department of Civil Engineering and Planning Education, Faculty of Engineering, YSU (2 the planning policies and the implementation of the OSH management need a continual improvement  and (3 the evaluation of the OSH management should be conducted simultaneously by the stakeholders, the lecturers and the technicians. (4 The OSH policy in the practices should be properly organised to promote the OSH culture in the workshop. (5 The OSH management control and review were prioritised for fostering the effectiveness of the OSH management implementation. Penelitian ini bertujuan untuk mengetahui perencanaan, pelaksanaan, dan  evaluasi Keselamatan dan Kesehatan Kerja (K3 di Bengkel Jurusan Pendidikan Teknik Sipil dan Perencanaan FT UNY. Penelitian ini merupakan penelitian deskriptif (descriptive reasearch yang memaparkan secara ilmiah keadaan di lingkungan bengkel khususnya mengenai aspek K3. Metode pengumpulan data menggunakan observasi, wawancara, dan angket. Analisis data menggunakan analisis deskriptif. Penelitian ini mendeskripsikan secara detail terhadap apa yang ditemukan dalam pengambilan data. Hasil penelitian ini menunjukkan bahwa: (1 Perencanaan K3 di bengkel masih perlu diperbaiki agar lebih matang dan sistematis. (2 Pelaksanaan K3 di bengkel masih perlu ditingkatkan terkait dengan kebijakan perencanaan dan pelaksanaan. (3 Evaluasi K3 di bengkel perlu dilakukan secara simultan oleh pihak penentu kebijakan, dosen, dan teknisi. (4 Budaya K3 di bengkel masih perlu ditingkatkan dengan penetapan kebijakan mengenai K3 dalam proses pembelajaran praktik. (5 Faktor peninjauan dan peningkatan kinerja K3 perlu dilakukan untuk menjamin kesesuaian dan efektivitas penerapan sesuai Sistem Manajemen K3.

  17. Evaluasi Peraturan Pelayanan Perpustakaan di Perpustakaan Fakultas Ekonomika dan Bisnis UGM

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    Maryatun Maryatun

    2016-09-01

    Full Text Available Purpose –The purpose of this study was to identify the reasons for due date book returns, borrowers' attitude when exposed to fines, library efforts to minimize fines and evaluate the effectiveness of fines in the library. Design/methodology/approach – This study used descriptive quantitative and qualitative approach. It was conducted at the Library of the Faculty of Economics and Business, Universitas Gadjah Mada. Samples were purposively selected, involving undergraduate and postgraduate students batch 2011, 2012 and 2013 that never got fines and were still active. Findings – Borrowers had some reasons for overdue book returns, such as they forgot renewing the book, the book was booked by another user, they forgot the due date, they had no class to attend, had not finished reading, borrowed in short period of time, as well as other reasons, such as illness, a friend borrowed the book. So the term of the loan for 5 days was considered insufficient for them to read the books. Borrowers had to pay fines directly. If they were not yet able to pay the fines then they would not borrow books. Borrowers knew that overdue books would put other users at a disadvantage. Most of borrowers considered the fine to pay as much as Rp5,000.00 /day/book was high. But a few regarded it low. Borrowers considered that blocking the system was not effective for those who were late paying fines. The most effective effort that could be done in order that the borrower returned the books on time was providing online renewal system.

  18. Hubungan Body Mass Index dengan Laju Aliran Saliva (Studi pada Mahasiswa Fakultas Kedokteran Gigi Universitas Andalas

    Directory of Open Access Journals (Sweden)

    Fildzah Nurul Fajrin

    2015-12-01

    Relationship between Body Mass Index and Saliva Flow Rate (A Study in Faculty of Dentistry, Andalas University. Saliva flow rate is an affecting factor of caries formation. Adequate saliva flow rate can prevent cariess formation process and progression of periodontal disease and oral infection. Nutritional status is known as an influencing factor of saliva flow rate. The parameter of nutritional status is Body Mass Index (BMI. The purpose of this study is to discover the relation between BMI and saliva flow rate in College Students of the Dentistry Faculty Andalas University. This observational study with cross sectional design was conducted to 24 college students of the Dentistry Faculty Andalas University whose ages were 18-25 years old who complied with inclussion and exclussion criteria. BMI was calculated with BMI formula. The saliva flow rate was determined with Sialometry Method of Navazesh 2008 with ”ml/minute” unit. The univariat data analysis was caried out to describe each variable. Normality test Kolmogorov Smirnoff was done to see the normal distribution (p > 0,05. After the distribution was proven to be normal, corelation and regression test was executed to discover the relation between BMI and saliva flow rate. Based on the correlation test result, BMI of college students of the Dentistry Faculty Andalas University is χχ ± SD = 24,6 ± 6,02 kg/m2 and saliva flow rate is χχ ± SD = 0,29 ± 0,1 ml/minute. The relation between BMI and saliva flow rate expresses medium correlation with negative direction ( r = - 0,451. The result of linear regression shows that Saliva Flow Rate = 0,404 - 0,008*(BMI. The coefficient of regression BMI 0.008 shows that increasing 1 unit of BMI will decrease saliva flow rate 0,008 ml/minute. This study concludes that there is correlation between Body Mass Index and saliva flow rate. Obesity group has the lowest saliva flow rate, while the saliva flow rate does not decrease in underweight group.

  19. SISTEM INFORMASI SECARA ONLINE TUGAS AKHIR MAHASISWA JURUSAN TEKNOLOGI INFORMASI FAKULTAS TEKNOLOGI INFORMASI DAN KOMUNIKASI

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    Atmoko Nugroho

    2015-08-01

    Full Text Available Tugas Akhir is the last stage that will surely passed by students to earn college scholarship. And one of the activities in the field of data administration is to manage file of Tugas Akhir, especially for the submission title and Coordinators of Tugas Akhir. Coordinators are often difficult to check the title of Tugas Akhir, if it has been filed or is pending, and the difficulties in monitoring the load guidance from their Supervisor of Tugas Akhir. This also forms the basis for making an Information System of Tugas Akhir (Sistem Informasi Tugas Akhir with the aim of assisting Jurusan Teknologi Informasi and students take this. Sistem Informasi Tugas Akhir called SITA also be made online this method applying Prototype system development. Prototype method according to Pressman has experienced several stages, namely: collection needs (listen to customers, design (built / REVISE mock-up and evaluation of prototypes (customer test-drives a mock-up. The collection needs to be done, among others, the acquisition of data. The data used in this information system is the data of Tugas Akhir of Jurusan Teknologi Informasi. The next stage in the design, researchers uses planning tool in the form of Unified Modeling Language system (UML and developed using the PHP programming language. System of web-based information created a purpose to be accessible without being restricted by time and place, whereas the benefit derived is facilitated student and coordinator duties in management of Tugas Akhir.

  20. Prevalensi Kejadian Insomnia pada Mahasiswa Fakultas Kedokteran Univesitas Sematera Utara Tahun 2015

    OpenAIRE

    Pamungkas, Anugrah Octa

    2016-01-01

    Insomnia is defined as difficulty to initiate sleep complaints. Difficulty maintaining sleep or experiencing non-restorative sleep, and usually associated with problems in the daytime activity. Insomnia is a sleep disorder that is most commonly found and experienced by many college students. The purpose of this study was to determine the prevalence of insomnia in medical student at University of North Sumatra in 2015, used a descriptive study with cross sectional approach. This research using...

  1. FAKOR-FAKTOR YANG MEMPENGARUHI PROKRASTINASI AKADEMIK PADA MAHASISWA FAKULTAS PSIKOLOGI UIN SUNAN GUNUNG DJATI BANDUNG

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    Hana Hanifah Fauziah

    2016-02-01

    Full Text Available The aim of this study was to determine the factors that influence academic procrastination among student as well as make the measuring instrument for academic procrastination. The research method was mixed method with exploratory sequential design. The study was conducted at the Faculty of Psychology UIN Sunan Gunung Jati Bandung with the number of respondents was 113 subjects chosen by disproportionate stratified random sampling. Technical analysis of qualitative data using interactive models while quantitative data using lisrel item analysis to confirm which factors have strong correlation with academic procrastination. The results obtained there were three factors that cause procrastination: physical, psychological, and environmental, with a correlation value for confirmatory analysis as follows 0.50 for the physical aspect, 0.55 for psychological aspects and environmental aspects with 0.92.

  2. Hubungan Kualitas dan Kuantitas Tidur dengan Prestasi Belajar pada Mahasiswa Fakultas Kedokteran

    OpenAIRE

    Fenny, Fenny; Supriatmo, Supriatmo

    2017-01-01

    Background: Sleeping is an essential need for every human beings in fulfilling their lives. There are two main components needed to put into consideration; they are sleeping quality and quantity. If the components are being distracted, it will cause impact on memory and concentration system. Consequently, it will cause the decline in academic achievements. The population who are at risk the most will be the collegestudents, especially medical students. Therefore, a research is conducted in or...

  3. Hubungan Efikasi Diri dengan Coping Stress pada Mahasiswa Angkatan 2012 Fakultas Kedokteran Universitas Riau

    OpenAIRE

    Rizky, Elsavina; ", Zulharman

    2014-01-01

    Student in education life will face many obstacles where good self adapted and readiness is needed. Coping stress is a good principal for students to face their problems. Coping stress can be influenced by internal factors and external factors, one of internal factor is self efficacy. This research conducted to discover correlation between self efficacy and coping stress on medical students of Riau University on year 2012. This is an analytic correlation study with cross sectional approachmen...

  4. Analisis Penggunaan Uang Elektronik Pada Mahasiswa Fakultas Ekonomi Universitas Negeri Malang (Studi Kasus: Uang Elektronik Brizzi

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    Didin Elok Parastiti

    2015-03-01

    Full Text Available This research aimed to describe the interest of students on the use of BRIZZI electronic money. This research is qualitative descriptive by using case study method or approach. The results showed that integrated KTM (Student Identity Card does not increase the use of BRIZZI electronic money among students. Interest of students on the use of BRIZZI electronic money as a means of payment is still very low.

  5. PENERAPAN TOTAL QUALITY MANAGEMENT PADA PROGRAM STUDI MPI FAKULTAS TARBIYAH DAN KEGURUAN UIN ALAUDDIN

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    Syahid Syahid

    2017-12-01

    Full Text Available The purpose of this paper is to describe (1 the concept of total quality mana-gement, (2 the theoretical foundation of total quality management, and (3 the application of total quality management in Education management study program at the Faculty of Education and Teaching Science, UIN Alauddin Ma-kassar. There are some theoretical bases to support the implementation of TQM in educational institutions. One is the theory of Deming which can be identified from (a Deming’s chain reaction model, (b Deming’s continuous improvement cycle, (c Deming’s theory of Variance, and (d Deming's fourteen points of management. The application of TQM in Management Studies Program Faculty of Tarbiyah and Teaching Education UIN Alauddin have not maximized. The data indicated that 70.19% respondents said that the implementation of TQM is at a mediocre level, 0.90% respondents said good, and 1.85% respondents said that the implementation of TQM has been very good.

  6. PENERAPAN TOTAL QUALITY MANAGEMENT PADA PROGRAM STUDI MPI FAKULTAS TARBIYAH DAN KEGURUAN UIN ALAUDDIN

    OpenAIRE

    Syahid Syahid

    2017-01-01

    The purpose of this paper is to describe (1) the concept of total quality mana-gement, (2) the theoretical foundation of total quality management, and (3) the application of total quality management in Education management study program at the Faculty of Education and Teaching Science, UIN Alauddin Ma-kassar. There are some theoretical bases to support the implementation of TQM in educational institutions. One is the theory of Deming which can be identified from (a) Deming’s chain reaction mo...

  7. KINERJA UNIT DALAM MENDUKUNG PENGEMBANGAN FAKULTAS ILMU ADMINISTRASI UNIVERSITAS LANCANG KUNING

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    Prihati Prihati

    2018-02-01

    Full Text Available Performance Faculty of Administrative Sciences can be seen from the performance of employees. This study focuses on the performance of existing units in the Faculty of Administration in carrying out its main duties and functions in order to support the strengthening of Faculty's performance. But in reality the performance of existing units in the faculty of administration of the University of Lancang Kuning showed less satisfactory work. Indicators that are visible include unstructured unit work programs, inadequate facilities and infrastructure, limited budget support and weak leadership which are a constraint in motivating employees to do their job well. The objective of the study was to explain the performance of faculty units and their inhibiting factors. The research method uses qualitative with emphasis on the concept of performance measurement. The techniques used in data collection are observation, interview and documentation study. The results showed that the performance of the faculty unit has not run well, this is obtained from the measurement of performance indicators that include job performance, expertise, behavior and leadership. As for the inhibiting factors of faculty unit performance is the limited support of facilities, infrastructure and funding. Besides, the reward and punishment system has not been done to the employee job resulting in the employee's motivation in working to be reduced, besides it is necessary to be given guidance and training for the work unit to understand the duty and function properly.

  8. Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells.

    Science.gov (United States)

    Khan, Arif A; Srivastava, Ruchi; Chentoufi, Aziz A; Geertsema, Roger; Thai, Nhi Thi Uyen; Dasgupta, Gargi; Osorio, Nelson; Kalantari, Mina; Nesburn, Anthony B; Wechsler, Steven L; BenMohamed, Lbachir

    2015-07-01

    Most blinding ocular herpetic disease is due to reactivation of herpes simplex virus 1 (HSV-1) from latency rather than to primary acute infection. No herpes simplex vaccine is currently available for use in humans. In this study, we used the HLA-A*02:01 transgenic (HLA Tg) rabbit model of ocular herpes to assess the efficacy of a therapeutic vaccine based on HSV-1 gD epitopes that are recognized mainly by CD8(+) T cells from "naturally" protected HLA-A*02:01-positive, HSV-1-seropositive healthy asymptomatic (ASYMP) individuals (who have never had clinical herpes disease). Three ASYMP CD8(+) T-cell epitopes (gD(53-61), gD(70-78), and gD(278-286)) were linked with a promiscuous CD4(+) T-cell epitope (gD(287-317)) to create 3 separate pairs of CD4-CD8 peptides, which were then each covalently coupled to an Nε-palmitoyl-lysine moiety, a Toll-like receptor 2 (TLR-2) ligand. This resulted in the construction of 3 CD4-CD8 lipopeptide vaccines. Latently infected HLA Tg rabbits were immunized with a mixture of these 3 ASYMP lipopeptide vaccines, delivered as eye drops in sterile phosphate-buffered saline (PBS). The ASYMP therapeutic vaccination (i) induced HSV-specific CD8(+) T cells that prevent HSV-1 reactivation ex vivo from latently infected explanted trigeminal ganglia (TG), (ii) significantly reduced HSV-1 shedding detected in tears, (iii) boosted the number and function of HSV-1 gD epitope-specific CD8(+) T cells in draining lymph nodes (DLN), conjunctiva, and TG, and (iv) was associated with fewer exhausted HSV-1 gD-specific PD-1(+) TIM-3+ CD8(+) T cells. The results underscore the potential of an ASYMP CD8(+) T-cell epitope-based therapeutic vaccine strategy against recurrent ocular herpes. Seventy percent to 90% of adults harbor herpes simplex virus 1 (HSV-1), which establishes lifelong latency in sensory neurons of the trigeminal ganglia. This latent state sporadically switches to spontaneous reactivation, resulting in viral shedding in tears. Most blinding

  9. STRATEGI PENINGKATAN KINERJA PROGRAM STUDI MELALUI OPTIMALISASI PERAN PIMPINAN

    Directory of Open Access Journals (Sweden)

    S. Martono

    2013-03-01

    Full Text Available Tujuan dari penelitian ini adalah mengungkap pengaruh gaya kepemimpinan terhadap budaya organsiasi, kerjasama tim dan kinerja organisasi. Tugas dan peran seorang pemimpin di tingkat unit organisasi sangat menentukan kualitas kerja. Fakta di lingkungan perguruan tinggi menunjukkan bahwa tidak semua pimpinan mampu memahami Prodi secara utuh. Sampel ditentukan dengan proportional random sampling berjumlah 139 orang. Variabel penelitian meliputi gaya kepemimpinan, kerjasama tim, budaya organisasi, dan kinerja organisasi. Data dikumpulkan dengan angket, analisis menggunakan Structural Equation Modeling (SEM. Hasil penelitian menunjukkan variabel gaya kepemimpinan tidak berpengaruh langsung terhadap kinerja organisasi prodi, tetapi berpengaruh tidak langsung melalui budaya organisasi dan kerjasama tim. Variabel kerjasama tim berpengaruh langsung maupun tidak langsung melalui budaya organisasi, terhadap kinerja organisasi Prodi. Saran dari penelitian ini adalah pimpinan mengembangkan budaya kerja melalui pemberian contoh, sikap dan perilaku dalam memanfaatkan sumber daya yang ada di fakultas, jurusan dan prodi. The objective of this study is to analyze the influence of leadership styles on an organizational culture, teamwork and organizational performance. Behavior and how a head department plays a role of a leader will determine people work quality. There are findings that in universities, not all leaders are able to comprehensively understand what program department scope’s is. The sample was determined by proportional random sampling totaled 139 people. The variables of study include leadership styles, teamwork, organizational culture, and organizational performance. Data were collected by questionnaires, analysis using Structural Equation Modeling (SEM. The results showed leadership style variable does not directly influence organizational performance of program department, but indirectly through the influence of organizational culture and

  10. Karakteristik Gejala Dysmenorrhea dan Pengaruhnya Terhadap Aktivitas Belajar Mahasiswi S1 Keperawatan Kelas Ekstensi di Fakultas Keperawatan USU

    OpenAIRE

    Roza, Desni

    2011-01-01

    Dysmenorrhea adalah nyeri saat menstruasi yang terjadi pada perut bagian bawah yang terasa seperti kram yang dimulai saat menstruasi datang sehingga dapat menimbulkan gangguan aktivitas sehari-hari. Wanita yang mengalami dysmenorrhea mempunyai tingkat gejala nyeri yang berbeda-beda pada setiap wanita yang mengalaminya mulai dari gejala nyeri dysmenorrhea ringan sampai berat. Penelitian ini bertujuan untuk mengidentifikasi karakteristik gejala dysmenorrhea dan pengaruh terhadap aktifitas belaj...

  11. Hubungan Tingkat Kecemasan dalam Menghadapi Objective Structured Clinical Examination (OSCE dengan Kelulusan OSCE pada Mahasiswa Fakultas Kedokteran Universitas Andalas

    Directory of Open Access Journals (Sweden)

    Dinda Putri Amir

    2016-01-01

    Full Text Available AbstrakKecemasan adalah normal terjadi dalam kehidupan, namun kecemasan dapat menjadi abnormal jika respons terhadap stimulus berlebihan. Pada mahasiswa, kecemasan berpengaruh terhadap proses pendidikan. OSCE merupakan salah satu bagian dari ujian komprehensif yang menguji keterampilan medis mahasiswa yang akan memasuki kepaniteraan klinik. Ujian ini hampir sama dengan ujian skills lab, tapi materi ujian lebih banyak dan setting ujian juga berbeda sehingga situasi tersebut menimbulkan kecemasan pada mahasiswa menjelang OSCE. Tujuan penelitian ini adalah menentukan hubungan tingkat kecemasan dalam menghadapi OSCE dengan kelulusan OSCE pada mahasiwa FK Unand. Jenis penelitian ini adalah deskriptif analitik dengan sampel sebanyak 34 orang. Data diperoleh melalui wawancara kepada peserta OSCE menggunakan kuesioner Hamilton Rating Scale for Anxiety (HRS-A dan Bagian Akademik FK Unand yang selanjutnya dianalisis melalui uji korelasi Gamma dan Somers’d. Hasil penelitian ini didapatkan nilai koefisien korelasi (r sebesar -0,106 dan nilai signifikansi p>0,05. Berdasarkan hasil penelitian dapat disimpulkan bahwa tidak terdapat hubungan yang bermakna antara tingkat kecemasan dalam menghadapi OSCE dengan kelulusan OSCE pada mahasiwa FK Unand.Kata kunci: kecemasan, ujian, OSCE, HRS-A AbstractAnxiety normally occurs in life, but anxiety can become abnormal if the response to the stimulus is excessive. In student, anxiety affects the educational process. OSCE is a part of comprehensive exam that examine medical skills of the students who will enter their clinical stage. Although this exam is similiar like skills lab exam but the matters of exam is more complex and the setting of exam is different too, so these situations cause anxiety in students toward OSCE. The objective of this study was to determine the correlation between anxiety level in facing OSCE to students’ graduation of OSCE in Faculty of Medicine Andalas University. This study was a descriptive analytical and total sample of 34 people. Data were collected through interviewing the students use the questionnaire of Hamilton Rating Scale for Anxiety (HRS-A and Academic Department of Faculty of Medicine Andalas University. It was analyzed by Gamma and Somerd’s correlation test. The result of this study found a correlation coefficient (r is -0,106 and level of significance (p >0,05.  Based on the result, it can be concluded  that there is no correlation between anxiety level in facing OSCE with students’ graduation of OSCE in Faculty of Medicine Andalas University.Keywords: anxiety, exam, OSCE, HRS-A

  12. Pengaruh Penggunaan Gadget dengan Pola Tidur Pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Angkatan 2011, 2012 dan 2013

    OpenAIRE

    Siti Nurul Bahirah Binti Ramly

    2016-01-01

    Background: The gadget has playedan important role in human life. According to Ministry Of Education and Information, there’s 240 millions gadgets owned by 67% people in Indonesia. Many studies have shown that the use of the gadget before sleep has negativeeffects. The existence of electronic media in the bedroom and the use of electronic media influences sleep pattern, sleep duration and causes sleep disorders among users. Objective: To determine the effect of theuse of gadgets on the sl...

  13. Tingkat Stres Pada Mahasiswa Malaysia Semester I Fakultas Kedokteran Gigi Universitas Sumatera Utara Tahun Akademik 2013/2014

    OpenAIRE

    Wukar Hussain, Rabiah Irfah

    2014-01-01

    Stepping into university is a big step in one's life. Lifestyle changes, academic achievement, a solid schedule of lectures, problem peers, adapt away from home for the first time and with the new environment can trigger the occurrence of stress in first y ear students. Plus, if these first year students are international students from Malaysia migrated to Medan to study dentistry. These first year students from Malaysia must adjust to the new environment affectively, behavi...

  14. Pengaruh Brand Image Terhadap Proses Keputusan Pembelian Sepatu Nike (Studi Pada Mahasiswa Fakultas Komunikasi dan Bisnis Telkom University Bandung

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    Dwi Ajeng Wulandari

    2017-06-01

    Full Text Available In modern times, developments in the world of fashion is growing by leaps and bounds. One of the highly developed is the trend of shoes. Sales of Nike shoes increases every year, as a result many companies that want to take advantage by selling shoes that quality is not in accordance with company standards. This study aimed to analyze the effect of Brand Image tehadap Nike Shoes Purchase Decision Process (Studies in the Faculty of Communication and Business Student Telkom University Bandung. This research includes quantitative research. The method used is descriptive - causal. The population in this study were students of the Faculty of Communication and Business Telkom University who uses Nike shoes. The sampling technique used is nonprobability sampling with the sampling method incidental sampling. The data collection is done by distributing questionnaires to 100 respondents. Data analysis technique used is simple linear regression analysis. Based on the results, it can be concluded that Brand Image positively influence the purchase decision process Nikes on students of the Faculty of Communication and Business Telkom University Bandung. It can be seen from the results of the t> t table (12.257> 1.98447 and the level of significance, 000 <0.05. Based on the calculation coefficient of determination (R2 can be seen the influence of brand image variable (X on the purchase decision process (Y amounted to 60.5%. While the remaining 39.5% is influenced by other factors.

  15. PENGARUH WORK LIFE BALANCE DAN KETERIKATAN PEGAWAI TERHADAP KINERJA PEGAWAI FAKULTAS ILMU SOSIAL DAN ILMU POLITIK UNIVERSITAS INDONESIA

    OpenAIRE

    Sarikit, Maya

    2017-01-01

    The objective of the research is to obtain information about the influence of work life balance and employee engagementon employees job performance onFaculty of Social and Political Sciences of the University of Indonesia .The research was conducted to all of employees onFaculty of Social and Political Sciences of the University of Indonesia by using a survey method with path analysis applied in testing hypothesis. The number 67 employees as sample was selected by using Slovin formula. The re...

  16. Konsumsi Yoghurt Dan Persepsi Pada Mahasiswa Fakultas Kesehatan Masyarakat Universitas Sumatera Utara Tahun Angkatan 2012-2015

    OpenAIRE

    Ramadhani, Fattia

    2016-01-01

    To keep maintance body health, it must keep the amount of non pathogenic bacteria in the gut in order to stay balanced. The increasing number of bacteria in the gut, it will boost immunity to the disease. It caused by the good bacteria that stimulate various factors prophylactic. Eating yoghurt is one effort in keeping it healty digestion. Yoghurt is one of functional food which fermented from milk by Using Lactic Acid Bacteria (LAB). Presence of Lactic Acid Bacteria in yoghurt provides a lot...

  17. Strategi Program Studi untuk Meningkatkan Brandawareness (Studi pada Prodi Ilmu Komunikasi Fakultas Ilmu Sosial Humaniora UIN Sunan Kalijaga)

    OpenAIRE

    Purwani, Diah Ajeng

    2015-01-01

    : Brand awareness is related to the strength of the brand in memory. Brand awareness is reflected by consumers' ability to identify various brand elements. This research explains that brands have become important drivers of growth for any university,department, good or service. A strong university brand makes people aware of what the university represents and about the different offerings of the university. The main reason consumers flock to some department in university and ignore others is ...

  18. ANALISIS FAKTOR-FAKTOR DALAM KUALITAS KEHIDUPAN KERJA (QUALITY WORK LIFE) DI FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA

    OpenAIRE

    Widyastuti, Umi; Purwana, Dedi

    2012-01-01

    Abstract Many factors determine the meaning of quality of work life (QWL). This research reviews the factors of QWL based on models and past research. The factors of QWL discussed are balance between life and non life, the work itself, skill utilization, working condition, job involvement, co-worker relationship, promotion, salary and supervisory. Confirmatory Factor Analysis is used to determine dominant factors of QWL. This research concludes that all the factors we discussed have the va...

  19. Strategi Pemasaran Gadget Dengan Menggunakan Metode Rantai Markov Dan Teori Permainan (Studi Kasus: Mahasiswa Fakultas Matematika Dan Ilmu Pengetahuan Alam).

    OpenAIRE

    Pakpahan, Endang J

    2016-01-01

    In line with the development of the times, technology is one important aspect which is also experiencing rapid development. Both in the field of telecommunications, information, and more. Various products are created to support the development of the times and people are increasingly thinking and creativity to poduce better products than before. This has resulted in intense competition among similar industries to scramble consumer in the market. Gadget is a small electronic device that has a ...

  20. Kondisi Periodontal Akibat Pemakaian Piranti Ortodonti Cekat Pada Pasien Di Klinik Ortodonti Rsgm Fakultas Kedokteran Gigi, Universitas Sumatera Utara

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    Yahya, Nur Adila Binti

    2015-01-01

    Evaluation on correlation of fixed orthodontic appliance with periodontal conditions on patients in Orthodontic clinic (RSGM) of Dentistry Faculty, University of North Sumatera. IX + 38 pages Fixed orthodontic appliance is an appliance that is fixed on teeth that cannot be opened by patients. Fixed orthodontic appliance may cause many oral complications due to the difficulities in maintaining good oral hygiene. Plaque is formed with the appliance of fixed orthodontic appliance which o...

  1. REVITALISASI DAN PEMBERDAYAAN FAKULTAS USHULUDDIN DAN DAKWAH: Kajian Atas Pengembangan Fak. Ushuluddin Dan Dakw IAIN Sultan Maulana Hasanuddin Banten

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    Mohamad Hudaeri

    2014-06-01

    Full Text Available Faculty of Islamic Theology and Communication have an important position as a scientificcore or basic sciences in Islamic study that have a strategic role both in the development of Islamicknowledge or in character building. However, it is a reality, Theology is a faculty that hasfewer students than other faculties.But in fact, they had good quality. In this regard, the revitalization and empowermentat the faculty of Islamic Theology is an urgent matter. The article is focused on the search and analyze the existence of the Islamic Theologyand communication departmentof Islamic State of Sultan MaulanaHasanuddin, both in terms of its strengths and weaknesses, as well as the expectations and the challenges it faced. Therefore, this study includedinternal institutional and academic aspects and society's view toward the existenceof the Islamic Theology and Communication Department.

  2. Integrasi Algoritma K-Means Dengan Bahasa SQL Untuk Klasterisasi IPK Mahasiswa (Studi Kasus: Fakultas Ilmu Komputer Universitas Brawijaya

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    Issa Arwani

    2015-07-01

    Abstract Generally, clustering implemented with taking data from database to be stored temporarily in a program variable (eg, in an array then continue with clustering process.Directclustering where the data is storedby integrating the clustering algorithm using the SQL language on the DBMS is proposed.In this study focused on the design and implementation of K-means clustering algorithm on a Relational DBMS using the SQL language. The clustering process carried out with a case study of GPA student in the Faculty of Computer Science University of Brawijaya.Based on results with a variety of dimensions, the number of clusters and different distance calculation methods, has obtained clustering data correctly. Based on time complexity to review each stage of the implementation K - means using SQL and without SQL, showing the same results of asymptotic time complexity where phase euclidean distance still requires the highest time complexity. Keywords: Clustering, K-means, SQL, GPA (Grade Point Average

  3. Gambaran Perilaku Mahasiswa Dalam Menggunakan Plastik Dan Styrofoam Sebagai Kemasan Makanan Di Fakultas Kesehatan Masyarakat Universitas Sumatera Utara Tahun 2012

    OpenAIRE

    Fadli, Feri

    2013-01-01

    The usage of plastic and styrofoam as food packaging is behavioral example which damage and pollute the environment. The usage of plastic and styrofoam increase significantly and widely used thus causing health and environmental problems. The research aims to know the description of student’s behavior in using plastic and styrofoam as food packaging at Public Health Faculty of Sumatera Utara University in 2012. The type of this research is descriptive study with a survey method. The popul...

  4. Pengaruh Periklanan Rasional dan Emosional Terhadap Keputusan Pembelian Produk Sunsilk Pada Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Sumatera Utara

    OpenAIRE

    Putra, Cherry Amanca

    2015-01-01

    This study aims to identify and analyze the effect of rational advertising and emotional advertising to purchase decision Sunsilk of college students faculty of economics and business, university of sumatera utara. This study was conducted on college students faculty of economics and business, university of sumatera utara who making purchasing decisions, and the total of sample od 62 respondents and use the purposive sampling method. Hypothesis testing using descriptive analysis, significant ...

  5. Perbandingan Besaran Sferikal Ekuivalen Berdasarkan Metode Pengukuran Visus Subjektif dan Objektif Penderita Ametropia pada Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi

    OpenAIRE

    Palangi, Rezky; Lintong, Fransisca; Moningka Moningka, Maya

    2014-01-01

    : Ametropia or refractive error of the eye is the case almost every time we encounter in our environment and increasing steadily each year. One of the factors why refractive error often are not fully corrected due to the difference in the value of spherical and cylindrical or spherical equivalent between the examination of subjective and objective visual acuity. This study aims to determine the difference of the results of subjective and objective visual acuity at patiens ametropia. Analytica...

  6. Hubungan Kecanduan Online Game Dengan Indeks Prestasi Akademik Pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Angkatan 2012

    OpenAIRE

    Chandrasegaran, Swapna

    2016-01-01

    Background: The market share of online games are among the teens. Online gaming addiction (addiction to online games) is an extension of internet addiction (addiction to the internet). Online gaming addiction is a bound state of a person in a very strong habit and difficulties in letting go of the habbit of playing online game. Gaming addiction can cause significant losses. One disadvantage is that the player can be remiss in real life because they get deeply involved in the game. The phenome...

  7. Differential Item Functioning (DIF) Etnis pada Big Five Inventory (BFI) versi Adaptasi Fakultas Psikologi Universitas Sumatera Utara

    OpenAIRE

    Manik, Hitler

    2014-01-01

    Big Five Inventory (BFI) is one of personality test had been adapted into Indonesia language. More research had been developed to adapt the Indonesian Big Five Inventory. The purpose of this research is to check whether BFI’s personality test is fair if apply to ethnic of Batak Toba and Java. Therefore, examination of BFI’s items is needed. In psychology, especially in psychometric study, it is called Differential Item Functioning (DIF). Subject in this research is 327 people around 18 to 40 ...

  8. PROFIL KESADARAN DAN STRATEGI METAKOGNISI MAHASISWA BARU PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS ISLAM RIAU PEKANBARU

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    S. Amnah S.

    2014-04-01

    Full Text Available Telah dilakukan penelitian survai terhadap mahasiswa baru Pendidikan Biologi FKIP UIR tahun ajaran 2013/2014 untuk mengetahui profil kesadaran dan strategi  metakognitifnya. Populasi penelitian adalah mahasiswa baru Pend. Biologi tahun ajaran 2013/2014 sebanyak 6 kelas paralel. Sampel yang digunakan sebanyak 77% dari total populasi mahasiswa.  Dengan analisis deskriptif menunjukkan bahwa mahasiswa yang masuk dalam kategori Masih belum berkembang (MBB telah tidak ada (0 %. Sebanyak 3,24% mahasiswa masuk dalam kategori belum begitu berkembang (BBB; 25,41% mahasiswa masuk ke dalam kategori mulai berkembang (MB; 62,70%  masuk ke dalam kategori sudah berkembang baik (SBB atau OK; dan 8,65% mahasiswa masuk pada kategori super atau berkembang sangat baik. Sebanyak 39,45% telah dilatihkan menggunakan strategi metakognitif dalam belajar seperti membuat ringkasan (26,5%, menggaris bawahi bacaan (8,65%,membuat peta konsep (6,48%, dan membuat jembatan keledai/ titian ingatan (1,08%. A research survey among new students of Biology Faculty of Teacher Education UIR academic year 2013/2014 to determine the profile and awareness of metacognitive strategies. The study population was a new student Pend. Biology of the school year 2013/2014 as much as 6 parallel classes. The sample used by 77% of the total student population. With descriptive analysis showed that students who fall into the category of still undeveloped (MBB has no (0%. A total of 3.24% of students in the category of less developed (BBB; 25.41% of students fall into the category began to grow (MB; 62.70% belong to the category are well developed (SBB or OK; and 8.65% of students entered in the category of super or growing very well. A total of 39.45% has been trained in the use of metacognitive learning strategies such as preparing a summary (26.5%, underlining the reading (8.65%, create a concept map (6.48%, and create mnemonics / memory bridge (1.08%.

  9. UPAYA KOMUNIKASI PEMASARAN INTERAKTIF PADA KLINIK SPESIALIS TERPADU RUMAH SAKIT GIGI DAN MULUT (RSGM FAKULTAS KEDOKTERAN GIGI UNAIR SURABAYA

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    Made Asri Budisuari

    2012-11-01

    Full Text Available Integrated Marketing Communications (IMC constitute of internal marketing, interactive and external communications. This research only addresses Interactive marketing communications. The specialized Dental Clinic (Integrated VIP Specialist has been under utilized. The problem exists presumably due to lack of interactive communications. The objective of this research is to formulate an IMC improvement effort for the Specialized Dental Clinic.This was an observational study conducted at the Specialized Dental Clinic from February up to Desember 2003. Observed variables were patient and organization of the clinic. Customers who visited the Specialized Dental Clinic were observed from the initial services the exit interview using questionnaire was collected by researche. The respondens were providers and customers (patientsThe result showed that the variable of customer service center and servicescapes were not well organized while personal selling relatively good.It is suggested that market survey should be done by the Specialized Dental Clinic, to actuate interactive marketing communication and to establish the utilization targets.

  10. PENGARUH PEMBELAJARAN E-LEARNING TERHADAP HASIL BELAJAR MATA KULIAH STATISTICS MAHASISWA TADRIS BAHASA INGGRIS FAKULTAS TARBIYAH IAIN WALISONGO

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    lulu choirunissa

    2016-03-01

    Full Text Available Mata kuliah Statistics (Statistika Pendidikan untuk prodi yang lain merupakan mata kuliah wajib di IAIN Walisongo. Di prodi Tadris Bahasa Inggris, pembelajaran mata kuliah Statistics selama ini mempunyai beberapa hambatan, antara lain mahasiswa kesulitan dalam pemahaman konsep, keterampilan berhitung, dan kurangnya waktu untuk berlatih. Bersamaan dengan kerjasama IAIN Walisongo dengan DBE 2 USAID untuk pembelajaran jarak jauh, dibuatlah kelas online untuk mata kuliah statistika yang memungkinkan mahasiswa untuk berdiskusi, menyelesaikan statistika uji dengan komputasi, memahami konsep statistika melalui video dan bahan bacaan, serta berinteraksi dengan dosen jika mahasiswa mengalami permasalahan. Selanjutnya ingin diketahui apakah pembelajaran dengan e-learning berpengaruh terhadap hasil belajar mahasiswa. Hasil dari studi menunjukkan bahwa tidak terlihat pengaruh yang signikan, namun jumlah mahasiswa yang mendapat nilai A, B+, dan B lebih banyak pada pembelajaran dengan e-learning dibandingkan dengan mahasiswa pada pembelajaran konvensional.

  11. FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUTUSAN MAHASISWA MEMILIH FAKULTAS EKONOMI UNIVERSITAS ISLAM SUMATERA UTARA AL MUNAWAROH MEDAN

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    Wan Suryani

    2013-02-01

    Full Text Available In this globalization era competition among universities to attract students getting tougher. It is therefore universities should further strenghten its marketing strategy, so that they can attract new students to decide to study in the Faculty of Economics, Islamic University of North Sumatra, Medan. This study aims to determine what factors are influencing students in choosing education at Faculty of Economics, Islamic University of Al Monawaroh Medan North Sumatra. The number of samples used in this study were 83 people who are students at the Faculty of Economics, Islamic University of Al Munawaroh Medan North Sumatra. Sampling performed by the method of proportionate random sampling. Data were collected using questionnaires. Variables Measurement with Likert scale in 5 (five scale. Prior to data collection, questionnaire were tested  by validity and reliability test using 30 (thirty respondents. The validity test using the Pearson correlation that  correlate each item with total score of items and the reliability test using Cronbach Alpha. The result shows that factors must consider by the student when decided the Economy Faculty of UISU Al Munawaroh Medan are process, motivation, physical evidence, reference, cost, and location

  12. KESESUAIAN ANTARA CITA-CITA DAN PEMILIHAN PROGRAM STUDI MAHASISWA FAKULTAS AGAMA ISLAM ANGKATAN 2013/1014

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    Mahasri Shobahiya

    2014-11-01

    The dreams that match with its mission and objectives of faculty are quite large ( 62 % , who aspires to be a teacher and lecturer of IS. Students of Islamic law ( Sharia that match with the ideals and objectives of the faculty is very small ( 3 % , which aspires to be a judge / prosecutor .

  13. KEPUASAN MAHASISWA TERHADAP “SERVICE QUALITY” DI FAKULTAS TEKNIK UNIVERSITAS DIPONEGORO MENGGUNAKAN METODE “STUDENT SATISFACTION INVENTORY”

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    Zainal Fanani R

    2012-02-01

    Full Text Available College is a service industry providing service activities of higher education, where quality of service andproduct have must be committed to customer satisfaction orientation. Diponegoro University as one of TheState University which is located in Semarang Central Java become research object at this research about thequality of service education.This research uses Student Satisfaction Inventory method which was developed by Noel Levitz. This methodmeasure service quality based on eleven dimension, there are Academic Advising, Campus Climate, CampusLife, Campus Support Services, Concern for the Individual, Instructional Effectiveness, Recruitment andFinancial Aid Effectiveness, Registration Effectiveness, Campus Safety and Security, Service Excellence, andStudent Centeredness.The research was done by survey of student satisfaction. The sample are student of Technical Faculty UNDIPwhich is taken proportionally from 8 study program of Engineering Faculty in UNDIP. There are two differentscore for each item on the survey, the importance score, and the satisfaction score. The assessment of qualityservice education based on the difference in the importance score and satisfaction score, so called withperformance gap score.The result shows that the highest importance score is campus supports service (4.65, the highest satisfactionscore is campus climate (3.29 and the highest performance gap is campus support services (1.61. Value oftotal mean performance gap is 1.44. According to the guidelines provided by Noel Levitz, a performance gapbetween zero and 1.50 indicates that the institution (UNDIP is almost meeting students expectation. From theperspective of engineering students, Electrical Engineering student feel most satisfied to service educationgiven by UNDIP than student from other engineering majors. The other result of this research indicates thatthere are 14 variables from 66 variables has high priority to be improved.

  14. PEMBUATAN ALAT LABORATORIUM FISIKA FAKULTAS ILMU TARBIYAH DAN KEGURUAN IAIN WALISONGO UNTUK PRAKTIKUM OSILASI CAIRAN DAN AYUNAN MATEMATIS SECARA DIGITAL

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    agus sudarmanto

    2016-02-01

    Hasil penelitian ini adalah bahwa pembuatan alat lab- oratorium sika  untuk praktikum osilasi cairan dan ayu- nan matematis secara digital sudah dapat berfungsi sesuai dengan yang diinginkan dan data hasil dari alat tersebut mendekati nilai percepatan gravitasi bumi sebenarnya yai- tu sebesar 9,8 m/s2.

  15. Desain Pengembangan Aktivitas Kemahasiswaan dengan Pendekatan Psychological Capital dalam Meningkatkan Minat dan Kemampuan Berwirausaha Mahasiswa Fakultas Ekonomi

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    M. Irfani Hendri

    2015-08-01

    Full Text Available This paper is to describe what has been done by the Faculty of Economics UNTAN in growing interest and entrepreneurship skills among students through student activities and currentevaluation tried to offer a development design of student activities with the approach ofpsychological capital that includes (1 the existence of self-confidence (self confidence; (2positive attribution (optimism; (3 resistance in achieving its objectives with the ability toredefine the path to reach the goal with the ability to redefine the path to peak at the destination ifrequired (hope; and (4 when facing problems and difficulties, able to survive and continueforward (resiliency to achieve success. The approach taken in this study is qualitative, type ofresearch is a case study. For purposes of analysis, data can be collected using triangulation ofdata collection methods which involves observation, interview documentation and Focus GroupDiscussion (FGD. It can be concluded that the hardest thing in the printing of an entrepreneur isthe mental change that is formed because of the mindset that the synergy of a wide range of ourdaily interactions (family, education, environment, etc.. It is an attempt to solve the mentalproblem needs to be a synergy of various growth entrepreneurship program that has a good andconcrete step in creating the entrepreneurs.

  16. PENGARUH PERFEKSIONISME TERHADAP PROKRASTINASI AKADEMIK PADA MAHASISWA YANG SEDANG MENGERJAKAN SKRIPSI DI FAKULTAS PSIKOLOGI UIN SUNAN GUNUNG DJATI BANDUNG

    OpenAIRE

    Titih Srantih

    2016-01-01

    Academic procrastination particularly happens to college students who are working on their thesis is assumed to be influenced by the attitude of their perfectionism. The purpose of this study is to determine how perfectionism has influence on the academic procrastination of the students who are doing thesis at the Faculty of Psychology UIN Sunan Gunung Djati Bandung. The study had conducted on the population of students who are working on a thesis in total 38 people. The design used was a non...

  17. Komplexní úloha. [Fakulta informačních technologií VUT v Brně

    Czech Academy of Sciences Publication Activity Database

    Kratochvíl, Petr

    2008-01-01

    Roč. 54, č. 5 (2008), s. 24-25 ISSN 0862-7010 R&D Projects: GA AV ČR IAA800330701 Institutional research plan: CEZ:AV0Z80330511 Keywords : architecture * 20th century Subject RIV: AL - Art, Architecture , Cultural Heritage

  18. KEPUASAN MAHASISWA TERHADAP “SERVICE QUALITY” DI FAKULTAS TEKNIK UNIVERSITAS DIPONEGORO MENGGUNAKAN METODE “STUDENT SATISFACTION INVENTORY”

    OpenAIRE

    Zainal Fanani R; Haryo Santoso; Ina Lusiana

    2012-01-01

    College is a service industry providing service activities of higher education, where quality of service andproduct have must be committed to customer satisfaction orientation. Diponegoro University as one of TheState University which is located in Semarang Central Java become research object at this research about thequality of service education.This research uses Student Satisfaction Inventory method which was developed by Noel Levitz. This methodmeasure service quality based on eleven dime...

  19. Kepuasan Mahasiswa Terhadap “Service Quality” Di Fakultas Teknik Universitas Diponegoro Menggunakan Metode “Student Satisfaction Inventory”

    OpenAIRE

    Fanani R, Zainal; Santoso, Haryo; Lusiana, Ina

    2007-01-01

    College is a service industry providing service activities of higher education, where quality of service andproduct have must be committed to customer satisfaction orientation. Diponegoro University as one of TheState University which is located in Semarang Central Java become research object at this research about thequality of service education.This research uses Student Satisfaction Inventory method which was developed by Noel Levitz. This methodmeasure service quality based on eleven dime...

  20. Perubahan Gaya Hidup Mahasiswa Fakultas Ekonomi Universitas Riau Asal Kecamatan Kandis Sebelum dan Sesudah Tinggal di Kota Pekanbaru

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    Enggraini, Irma Rizki; Tantoro, Swis

    2017-01-01

    Lifestyle is something that is beyond the personality. Lifestyle happens especially in the Faculty of Economics is of respondents noticed a significant change from other Faculties, starting from the change in the dress code that is used by students and staffs who work in that environment. The use of private vehicles ranging from motorcycles and cars that look more numerous than in other Faculties, the use of communication devices such as mobile phones (HP) more updates. With a style of life l...

  1. Evaluasi Literatur dengan Menggunakan Analisis Sitiran Terhadap Skripsi Jurusan Manajemen Hutan Tahun 2008 di Perpustakaan Fakultas Kehutanan UGM

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    Isbandini Isbandini

    2016-01-01

    Full Text Available The purpose of this research is : (1 to know the literature obsolescence cited on the 2008 theses Forest Management Department, Faculty of Forestry UGM (2 to know the growth of literature based on the type and language of collection which were mostly cited by students of the Forest Management Department, Faculty of Forestry UGM in writing theses during 2008, (3 to know the availability of a collection cited by students of the Forest Management Department, Faculty of Forestry Gadjah Mada University in writing theses in 2008, this study is a descriptive research, with research subjects is the theses of Forest Management, Faculty of Forestry Gadjah Mada University in 2008 which amounted to 67 theses and research objects is all the literature included in the cited bibliography on Forest Management theses, Faculty of Forestry Gadjah Mada University in 2008 which amounted to 1498. Method of data collection uses documentation. Data analysis uses citation analysis. The results show that: (1 the literature obsolescence of the theses aged 8 years or ;ess is up to date and aged more than 8 years is out of date (2 the growth of literature on this research shows 8 years, this means that the growth of Forest Management literature is quickly enough when compared with other sciences, while the growth of the literature based on literature and language of the literature indicates that the book is a kind of literature the most widely cited with citation 950 (63, 42%, the language of literature the most widely cited is the Indonesian-language literature with the 1328 citation (88.65%, (3 overall citation data in this study found 865 citation or 57.74% cited in the literature on theses writing is available at the library and as many as 633 or 42.26% citation is cited literature is not available in the library.

  2. Efektivitas Kegiatan Pendidikan Pemakai Perpustakaan Bagi Mahasiswa Baru Fakultas Ilmu Sosial dan Ilmu Politik (FISIPOL Universitas Gadjah Mada Tahun 2010

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    Sarjono Sarjono

    2015-11-01

    Full Text Available The research aims to examine the effectiveness of library user education activites for new students of Faculty of Social and Political Science (FISIPOL, Gadjah Mada University in Yogyakarta in 2010. This study is quantitative research. The population in this study is FISIPOL Gadjah Mada University freshman 2010/2011, with retrictions on the object educational activites at the library FISIPOL Gadjah Mada University in 2010 membering 651, and the sample taken is 65 students.

  3. Uji Ketergunaan Layanan Antarmuka Magister Management Digital Library (MM-Digilib Perpustakaan Magister Manajemen Fakultas Ekonomi Universitas Indonesia

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    Sri Sugianti

    2016-01-01

    Full Text Available A digital library is an advancement of a conventional library. Wider role of a digital library lies in its ability to give support for service via virtual/electronic/digital network. Through its revolutionary presence, a digital library needs a testfor development. One of the tests that can be used is usqge test of interface service of magister management Digital Library (MM-Digilib at Magister Management of Faculty of Economics, University of Indonesia. Based on theformula of Slovin and Nomogram Henry King, there are 8I valid samples out of 651 of master students accessing digital theses at Magister Management Library, Faculty of Economics, University of Indonesia. Out of indicators of usage test - efficiency, effictiveness, ease ofuse and ease ofinteraction of MM-Digilib is in general relatively good. Yet it needs to improve thefunction of Advanced Search in order to assist and shorten time in searching.

  4. Aplikasi Peminjaman dan Pengembalian Koleksi Berbasis Framework Code Igniter di Perpustakaan Jurusan Teknik Sipil dan Lingkungan Fakultas Teknik UGM

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    Bagus Wijaya

    2016-09-01

    Full Text Available A library is an important facility to support the academic activities of students. There are various types of collections that require good management in order that the information retained in the collections can be utilized by the user. The collection in the library can be easily borrowed and returned quickly so as to improve the efficiency and effectiveness of the performance of library staff. The author aimed to facilitate library staff in providing collection circulation services, especially for students majoring in Civil and Environmental Engineering. The application was expected to give fast and accurate process in data as well as report collection.

  5. PENGARUH MEROKOK TERHADAP pH SALIVA DAN AKTIVITAS ENZIM PTIALIN PADA MAHASISWA FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

    OpenAIRE

    sauqi, ahmad; Dwi Fitri, Amelia

    2017-01-01

    Abstract Background: Cigarettes can cause disturbances in the oral cavity. From previous research it is known that daily cigarette consumption impact on decrease of salivary secretion and bicarbonate content. This will affect the decrease in salivary pH. Low salivary pH also has an effect on decreasing ptialin enzyme activity. Departing from the basic theory, researchers want to see the extent to which smoking can affect salivary pH and pyalin enzyme activity in students of the Faculty of ...

  6. Pengaruh Efikasi Diri dan Motivasi Berwirausaha Terhadap Minat Berwirausaha Pada Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Sumatera utara

    OpenAIRE

    Sianipar, Nehemia Desi Hanayati

    2016-01-01

    The purpose of this research is to identify and analyze the influence of self-efficacy and entrepreneurship motivation towards entrepreneurship interest in Students Faculty of Economics and Business University of North Sumatera. The population in this research is the Entrepreneurship Concentration of Management Student Faculty of Economics and Business University of North Sumatera that add up to 164 people. The sample used in this study is the Entrepreneurship Concentration of Management Stud...

  7. Desain Pengembangan Aktivitas Kemahasiswaan dengan Pendekatan Psychological Capital dalam Meningkatkan Minat dan Kemampuan Berwirausaha Mahasiswa Fakultas Ekonomi

    OpenAIRE

    M. Fahmi, M. Irfani Hendri Indarti Rochayati

    2015-01-01

    This paper is to describe what has been done by the Faculty of Economics UNTAN in growing interest and entrepreneurship skills among students through student activities and currentevaluation tried to offer a development design of student activities with the approach ofpsychological capital that includes (1) the existence of self-confidence (self confidence); (2)positive attribution (optimism); (3) resistance in achieving its objectives with the ability toredefine the path to reach the goal wi...

  8. Penggunaan media sosial (facebook dan twitter)terkait dengan pencarian informasi kesehatan oleh Mahasiswa Fakultas Kesehatan Masyarakat Universitas Sumatera Utara

    OpenAIRE

    Sinaga, Rosmawat

    2015-01-01

    This research, entitled The Use of Social Media (Facebook and Twitter) related to Health Information Search By Faculty of Public Health University of North Sumatra, which aims to identify the use of social media, the attitude towards health information seeking on social media, and knowing action on health information seeking on the media social by students of the Faculty of Public Health Universitas Sumatera Utara. The theory is considered relevant that used in this research...

  9. PENGEMBANGAN PEMBELAJARAN MANAJEMEN DATABASE BERBASIS WEB CMS JOOMLA PADA MAHASISWA PENDIDIKAN ADMINISTRASI PERKANTORAN FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA

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    Roni Faslah

    2015-03-01

    Full Text Available This study aims to research, develop, test, and validate learning media database management for students in courses of Economic Education Department of Economics and Administration Faculty of Economics, University of Jakarta. Second, this development aims to produce instructional media in the form of web-based learning with joomla cms. Third, determine the thoroughness of learning outcomes and student response to the learning process with the media joomla website. This development method using silklus research and development (R & D Cycle from Borg and Gall (1983 were modified. Based on the results of expert assessment, teachers and field trials on the product web-based learning media cms joomla, has obtained results that product development is considered feasible and has been able to facilitate the achievement of learning objectives. The results of field tests of the experimental class in this development means that the student assessment shows that the analysis of the media validator developed a valid entry in the category with a score of validity of 3.45. Criteria practicality of this medium can also be fulfilled for media media joomla website developed can be used with minimal revision. Student Learning Results showed that 31 students have a positive impact as indicated by the increased value of learning outcomes. The response of students to instructional media joomla website shows that as many as 96% of the students showed a positive response to learning this media joomla website.

  10. ANALISIS FAKTOR-FAKTOR DALAM KUALITAS KEHIDUPAN KERJA (QUALITY WORK LIFE DI FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA

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    Umi Widyastuti

    2012-03-01

    Full Text Available Many factors determine the meaning of quality of work life (QWL. This research reviews the factors of QWL based on models and past research. The factors of QWL discussed are balance between life and non life, the work itself, skill utilization, working condition, job involvement, co-worker relationship, promotion, salary and supervisory. Confirmatory Factor Analysis is used to determine dominant factors of QWL. This research concludes that all the factors we discussed have the value of Keiser Meyers Oklin Measure of Sampling Adequacy more than 0.5, except salary. It means that eight factors which determine QWL are balance between life and non life, the work itself, skill utilization, working condition, job involvement, co-worker relationship, promotion and supervisory. After varimax rotation process and based on criteria eigenvalue more than 1, this research has formed two component from all the factors. Component 1 consist of the factor: balance between life and non life, working condition, promotion and supervisory. And component 2 consist of the factor: work itself, skill utilization, job involvement and co-worker relationship.

  11. PLURALISME AGAMA MENURUT PERSPEKTIF DOSEN-DOSEN FAKULTAS USHULUDDIN DAN HUMANIORA DAN STT GEREJA KALIMANTAN EVANGELIS (GKE BANJARMASIN

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    Slamet Karianto

    2015-10-01

    Full Text Available This script writing against the background of social conditions in South Kalimantan diverse in terms of ethnicity, or religion. We take the example of religious pluralism in South Kalimantan. This religious pluralism condition often we term Religious Pluralism. Religious Pluralism succession plays a very important to maintain the diversity and creating understanding of the harmony that lately in various areas, especially in Indonesia being tested. Religious pluralism is a perspective of religious harmony. This understanding of the role in order to be more effective is to educate every student either by teachers, lecturers and other teaching staff in order to achieve that purpose. Both from the Primary Education, Secondary, to university, both from High school and College of General. Results of field interviews showed that religious pluralism is understood by some of the Faculty of Islamic Theology and Humanities IAIN Antasari is a pluralism that if no further interpreted it leads to liberalism even to relativism and nihilism. However, if seen from what has been interpreted by some leaders of Religious Pluralism, then pluralism itself be accepted as a philosophy in building harmony. While others say that sociologically Religious Pluralism has to be accepted by Muslims without having interpreted the deeper, because Pluralism itself is not relativism, or even nihilism. Meanwhile, partially-Lecturer Lecturer STT Borneo Evangelical Church (GKE views of Religious Pluralism in context pluralistic society will be criticized for some faiths who are intolerant of other religions. While others consider only limited Religious Pluralism understand the differences and cooperation in specific social issues, without any compromise in theology, leading to the elimination of the role of God in life.

  12. SELF-REGULATED LEARNING DAN PERSEPSI DUKUNGAN SOSIAL DENGAN PRESTASI AKADEMIK MAHASISWA FAKULTAS USHULUDDIN IAIN IMAM BONJOL PADANG

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    Subhan Ajrin Sudirman

    2015-04-01

    Full Text Available This research aimed to examine the correlations between self-regulated learning and social support perception with students academic achievement at Ushuluddin Faculty of State Institute for Islamic Studies Imam Bonjol Padang. This research used purposive sampling technique. The subjects of this research were 150 students. The data were collected by using, (1 The self-regulated learning scale, (2 The social support perception scale, and (3 documentation. The data were analyzed by using multiple regression of SPSS 13.0 for windows. The results of this research are: (1 There is very significant and positive correlation between self-regulated learning and students academic achievement (r = 0,325, p < 0,001 and R² = 0,106; (2 There is very significant and positive correlation between social support perception and students academic achievement (r = 0,284, p < 0,001 and R² = 0,081.

  13. PERBEDAAN PROKRASTINASI AKADEMIK DALAM MENYELESAIKAN SKRIPSI PADA MAHASISWA FAKULTAS PSIKOLOGI UKSW BERDASARKAN TIPE KEPRIBADIAN A DAN B

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    Sutriyono Sutriyono

    2012-12-01

    semester genap 2011/2012 yang mengambil matakuliah skripsi dan skripsi lanjut dilibatkan. Alat pengumpul data menggunakan dua skala, yang pertama adalah modifikasi skala prokrastinasi Tuckman (Tuckman Procrastination Scale untuk mengukur tingkat prokrastinasi dan modifikasi skala Bortner untuk menggolongkan kedalam salah tipe kepribadian. Hasil penelitian menunjukkan bahwa secara signifikan, mahasiswa dengan kepribadian tipe A mempunyai tingkat prokastinasi dalam menyelesaikan skripsi lebih rendah dibandingkan dengan mahasiswa yang mempunyai tipe kepribadian B.

  14. PENGARUH PERFEKSIONISME TERHADAP PROKRASTINASI AKADEMIK PADA MAHASISWA YANG SEDANG MENGERJAKAN SKRIPSI DI FAKULTAS PSIKOLOGI UIN SUNAN GUNUNG DJATI BANDUNG

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    Titih Srantih

    2016-02-01

    Full Text Available Academic procrastination particularly happens to college students who are working on their thesis is assumed to be influenced by the attitude of their perfectionism. The purpose of this study is to determine how perfectionism has influence on the academic procrastination of the students who are doing thesis at the Faculty of Psychology UIN Sunan Gunung Djati Bandung. The study had conducted on the population of students who are working on a thesis in total 38 people. The design used was a non-experimental design with causality method. Measuring instruments used the Almost Perfect Scale Revised from Snaley (1992 and Procrastination Student Assessment Scale developed by Solomon and Rothblum (1984 with some adaptations. Technical analysis of the data using simple regression analysis with the result that the determination coefficient of influence perfectionism to academic procrastination is R2 = 0.065. The results of the t test, t = 1.582 < table = 1.684, so it can be concluded that there is no significant effect of perfectionism to the academic procrastination of students who are working on a thesis.

  15. Pengaruh Karakteristik Kewirausahaan terhadap Niat Berwirausaha pada Mahasiswa Fakultas Ekonomi Unisri dengan Motivasi Berwirausaha sebagai Variabel Moderasi

    OpenAIRE

    Lamidi, William Sumanjaya, Erni Widajanti &

    2016-01-01

    The purpose of this study was to analyze: 1) the effect of entrepreneurial characteristics on student's entrepreneurship intentions 2) the effect of entrepreneurship motivation on student's entrepreneurship intention, and 3) the effect of entrepreneurial characteristics on student's entrepreneurship intenton with on the entrepreneurship motivation as a moderating variable. This study is a survey. The study population were students of the Faculty of Economics Slamet Riyadi University Surakarta...

  16. Perilaku Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Tentang Konsumsi Makanan Siap Saji (Fast Food) Medan Tahun 2015

    OpenAIRE

    Rahayu, Try Desfi

    2015-01-01

    A survey which provided by AC Nielsen (2008) stated that 69% of cities in Indonesia used to consume the fast food. A total of 33% of them saidthat fast food is the choice for their lunch, 25% fortheir dinner, 9% fortheir such snack, and 2% for their breakfast. This condition will be growing along with the increasing consumption of fast food in Indonesia. This research provided by the authors aimed to determine the behavior of students of the Faculty of Medicine, University of North Sumatra (U...

  17. Desain dan Implementasi Standar Operasional Prosedur (SOP Keamanan Sistem Informasi Fakultas Teknik Universitas Diponegoro Menggunakan Standar ISO 27001

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    Penji Prasetya

    2015-08-01

    Full Text Available Like today's modern era, information technology is needed to support the business processes of the organization. In the use of information technology organization must have policies and standard operating procedures are good that any work carried out in the appropriate direction of the organization. Not only that, the organization must also pay attention to information security of any assets owned. This final project aims to make policies and standard operating procedures (SOP and assessing the information security risk in the assets of the organization. In the process of this skripsi refers to the standard of ISO 27001 as the standard for information security management and use of qualitative methodology, where qualitative methodology is a methodology that produces descriptive data in the form of words written or spoken of people and behaviors that can be observed. This final project resulted in the level of risk that is contained in the value of assets and generate recommendations to improve the security controls in the information security of assets based on the clauses of ISO 27001. In accordance with the initial objective of this final project also produce information security policy document and document information security standard operating procedures.

  18. PENERAPAN REGRESI PROBIT BIVARIAT UNTUK MENDUGA FAKTOR-FAKTOR YANG MEMENGARUHI KELULUSAN MAHASISWA (Studi Kasus: Mahasiswa Fakultas MIPA Unversitas Udayana

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    NI GUSTI KETUT TRISNA PRADNYANTARI

    2015-06-01

    Full Text Available The aim of this research to estimate the factors that affect students graduation using bivariate probit regression. Bivariate probit regression is a statistical method that involves two response variables which are qualitative and the independent variables are qualitative, quantitative, or a combination of both. In bivariate probit regression model, the result obtained is the probability of the response variable. The result of this research are the factors that affect significantly for students graduation based on study period are majors, sex, and duration of the thesis, while the factors that significantly for students graduation based on GPA are the entry system, duration of the thesis and the number of parents’ dependents.

  19. KAJIAN TINGKAT KONTINUM KAPITAL SOSIAL FAKULTAS TARBIYAH DAN KEGURUAN DALAM MENGWUJUDKAN VISI, MISI DAN TUJUAN UIN SULTAN SYARIF KASIM RIAU

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    Ansharullah Ansharullah

    2016-08-01

    Full Text Available The aims of this research are to find out the level of Social Capital Continuum and the what factors affecting the level of Social Capital Continuum employees and lecturers in the Faculty of Education and Teacher Training UIN Suska Riau. The subjects were employees and lecturers in the Education and Teacher Training UIN Suska Riau and the object is a levels of Social Capital Continuum of employees and lecturers in the Faculty Education and Teacher Training UIN Suska Riau. The population is all the structural employees (administration consist of 44 people and functional (lecturer of 158 Faculty of MT and Teaching UIN Suska Riau with the sampling method consists of two ways, namely variable structural employees using total sampling method and sampling methods for functional variables (lecturer using purposive sampling method. While research method used is descriptive qualitative method. The result of this research shows that the level of social capital continuum structurally and cognitive categories of employees and lecturer at the Faculty of Education and Teacher Training UIN Suska Riau in achieving the vision, mission and goals of the organization are in the category of Social Capital Maximum with the percentage of 79.90%, due to ranging between 76% - 100%.

  20. Pengaruh Kecerdasan Intelektual terhadap Kinerja Akuntan Pendidik pada Jurusan Akuntansi Fakultas Ekonomi dan Bisnis Universitas Halu Oleo

    OpenAIRE

    Akib, Mulyati; Asni, Nur

    2016-01-01

    This research aimed of presented to examine the effect of intellectual intellegence on the performance of educator accountant. Primary data in this research were obtained from the perseption off all lecturers and 76 generation students majoring 2013/2014 in Departement of Accountancy Economy faculty and Business Halu Oleo University. Preceptions in measured by responses to ques tionnaires that uses ordinal measurement with a 5 point Likert scale. The analytical tool used to test the hypotesis...

  1. PERAN PEMERINTAH DAERAH DALAM PEMBERDAYAAN PEREMPUAN DI KELURAHAN KALEGOWA, KECAMATAN SOMBA OPU KABUPATEN GOWA

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    Adzimat Tinur Haque

    2014-04-01

       Berbagai fenomena terkait dengan perempuan baik dalam bidang politik, ekonomi, sosial, dan budaya menciptakan perbedaan eksistensial antara laki-laki dan perempuan. Hingga melahirkan pemikiran bahwa kedudukan perempuan dan laki-laki berbeda, perempuan cenderung sebagai subordinat dalam rumah tangga. Untuk itu, dalam tulisan ini hendak melihat peran Badan Keluarga Berencana dan Pemberdayaan Perempuan dalam meningkatkan kualitas perempuan. Peneliian ini menggunakan penelitian deskriptif kualitatiff yaitu data yang dikumpulkan dideskriptifkan berdasarkan hasil wawancara langsung dan pengamatan langsung di lapangan. Peran Badan Keluarga Berencana Dan Pemberdayaan Perempuan dalam Pemberdayaan Perempuan yaitu dengan melakukan sosialisasi tentang kelompok usaha kepada peserta pemberdayaan, pendampingan mulai dari tahap persiapan, pelaksanaan hingga evaluasi, dan yang terakhir yaitu pelatihan yang didalamnya berisi pelatihan pembuatan jajanan pasar, pelatihan tas pesta dan pelatihan penjahitan, dalam kegiatan tersebut yang berfungsi sebagai pelaksana yaitu Badan Keluarga Berencana Dan Pemberdayaan Perempuan yang dibantu oleh LSM ( Lembaga Swadaya Masyarakat serta tim penggerak PKK, sedangkan yang berfungsi sebagai peserta yaitu perempuan yang akan melakukan pemberdayaan. Dengan berjalannya peran tersebut perempuan sudah bisa malakukan Akses, Kontrol, Manfaat dan Partisipasi.

  2. Tõhus ja õiglane menetlus õigusakti põhiseadusvastasuse nõude lahendamisel / Tim Kolk

    Index Scriptorium Estoniae

    Kolk, Tim

    2012-01-01

    Põhiseaduse § 15 lõike 1 teine lause sätestab igaühe õiguse nõuda oma kohtuasja läbivaatamisel mis tahes asjassepuutuva seaduse, muu õigusakti või toimingu põhiseadusvastaseks tunnistamist. Kohustustest, mis see säte paneb kohtunikele ning kuidas erinevates kohtumenetlustes seda õigust kasutada ja kohustusi täita

  3. Diskonteeritud rahavoogude mudel kehtib igal pool, igal ajal / Tim Koller, Marc Goedhart

    Index Scriptorium Estoniae

    Koller, Tim

    2005-01-01

    2005. a. kevadel 4. trükist ilmunud raamatu "Valuation" autorid leiavad, et ettevõtete juhid on huvitatud eelkõige järgmise kvartali tulemustest, tegelikult määravad kuni 80% ettevõtete väärtusest pea kõigis majandussektorites kaugemal kui 3 aastat ootavad rahavood. Seega seisneb ettevõtte tegelik väärtus hoopis stabiilsel ja pikaajalisel tulemuslikkusel

  4. In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?

    NARCIS (Netherlands)

    Havenaar, R.; Anneveld, B.; Hanff, L.M.; Wildt, S.N. de; Koning, B.A.E. de; Mooij, M.G.; Lelieveld, J.P.A.; Minekus, M.

    2013-01-01

    There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic,

  5. Analisis Pengaruh Kekuasaan dan Kemampuan Individu Anggota Tim (Studi Pada Pengaruh Keputusan Pembelian Batubara di Indonesia

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    Sukesi Sukesi

    2010-01-01

    Full Text Available Research on “organizational purchase behavior” is less developed compared to research on “consumer purchase behavior” due to the difficulty to get data from industries and organizational purchase behavior is influenced by more factors than consumer purchase behavior. Because of these reasons not many people willing to take a research on organizational purchase behavior. Some researchers who have studied organizational purchase behavior, most of them only emphasize on: purchase process, department influence, organizational size and organizational structure. Only few of them who studied interpersonal process especially in the area of “power” owned by individual members of buying center in the company. Latent power is the important key that can control and influence to other member team of buying center to agree with his or her decision. This research is using 188 respondents of buying center from 30 Indonesian coal buying companies, such as: Power Plant, Cement Plant, Paper Plant and Trader company. This research are use clustering and regression technique. Clustering technique is used to grouped the research objects and identify the characteristics of each object. Regression method is used to identify which power is the most dominant to influence the purchase decision on buying center. The result on this study are: Indonesian coal purchaser based on the buying center characteristics, situational characteristics and individual behavior: can be divided to be five cluster, such as: (1 high familiarity & viscidity, (2 high consideration to government regulation, (3 high risk, (4 small member size and high influence attempt and (5 high time pressure. Using the regression technique on each cluster, can be identified the strongest power that influence to the buying center, there are: cluster 1: ability on management power, cluster 2: reinforcement power, cluster 3: ability on engineering power, cluster 4: reinforcement power and cluster 5: reinforcement power.

  6. Analytical procedures for determining Pb and Sr isotopic compositions in water samples by ID-TIMS

    Directory of Open Access Journals (Sweden)

    Veridiana Martins

    2008-01-01

    Full Text Available Few articles deal with lead and strontium isotopic analysis of water samples. The aim of this study was to define the chemical procedures for Pb and Sr isotopic analyses of groundwater samples from an urban sedimentary aquifer. Thirty lead and fourteen strontium isotopic analyses were performed to test different analytical procedures. Pb and Sr isotopic ratios as well as Sr concentration did not vary using different chemical procedures. However, the Pb concentrations were very dependent on the different procedures. Therefore, the choice of the best analytical procedure was based on the Pb results, which indicated a higher reproducibility from samples that had been filtered and acidified before the evaporation, had their residues totally dissolved, and were purified by ion chromatography using the Biorad® column. Our results showed no changes in Pb ratios with the storage time.

  7. Briti kindral: Afganistan aitab värvata / Tim Radford ; intervjueerinud Evelyn Kaldoja

    Index Scriptorium Estoniae

    Radford, Tim

    2010-01-01

    Intervjuu endise Helmandi väekoondise juhi ja praeguse Suurbritannia kaitseministeeriumi välisoperatsioonide osakonna juhatajaga Afganistani sõja mõjudest Suurbrtiannia inimeste suhtumisele sõjaväkke ja sõjaväkke värbamisel

  8. Business ethics and financial performance : a practical and empirical approach / Tim Benijts

    Index Scriptorium Estoniae

    Benijts, Tim

    2001-01-01

    Mitmed organisatsioonid maailmas hindavad ettevõtteid nende eetilisusest lähtudes, näiteks Ethibel-Stock Belgias. Vaatamata ettevõtjate kartustele, ei lähe eetilistel ettevõtetel äris sugugi kehvemini

  9. Single Chondrule K/Ar ages of Mexican Meteorites Using ID-TIMS.

    Science.gov (United States)

    Hernandez, M.; Sole, J.

    2007-05-01

    We have determined the K/Ar ages of two H5 ordinary meteorites: Cosina and Nuevo Mercurio, neither dated until this study. We analyzed several single chondrules - weighing few milligrams - of each meteorite. Ages were obtained by using very precise K content determined by isotope dilution mass spectrometry. The K content in chondrules ranges between 650 and 1400 ppm. The 40Ar was measured by static vacuum noble gas mass spectrometry. Samples were fused with an infrared CO2 laser. Chondrule ages vary from 3.66 to 4.59 Ga for Cosina and from 4.20 to 4.87 Ga for Nuevo Mercurio. A comparison between our data and the published K/Ar ages of H and L whole rocks shows that dates obtained from single chondrules are older than those obtained from whole rocks and seem to preserve older events not evidenced in the WR ages. This implies that chondrules can preserve K/Ar ages very close to U-Pb crystallization ages.

  10. Tim Lang and Michael Heasman, Food Wars. The Global Battle for Mouths, Minds and Markets

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    Virginie Amilien

    2005-05-01

    Full Text Available Food wars can be understood as a war declaration against nowadays food-world. This book is full of images for a sustainable world which is opposition with the social and economic unfair society we live in. The authors propose quite concrete solution for a new food policy and draw a new frame for food policy and public health.Core arguments are simple: “Food policy is in crisis, in particular over health.” The unique model of food supply we have followed the last 50 years cannot continue that ...

  11. 1973 Winter Simulation Conference. Sponsored by ACM/AIIE/SHARE/SCi/TIMS.

    Science.gov (United States)

    Hoggatt, Austin Curwood, Ed.

    A record of the current state of the art of simulation and the major part it now plays in policy formation in large organizations is provided by these conference proceedings. The 40 papers presented reveal an emphasis on the applications of simulation. In addition, the abstracts of 28 papers submitted to a more informal "paper fair" are also…

  12. Riset Operasional Peningkatan Kinerja Tim Keselamatan Pasien Berdasarkan Standar Internasional Enam Tujuan Keselamatan Pasien

    OpenAIRE

    Widodo J. Pudjirahardjo, Moh Ainul Yaqin Darmawan Setijanto

    2012-01-01

    Background: Patient safety emphasizes reporting, analysis,and prevention of medical error that often leads to adversehealthcare events. In 2010, there were 60 incidents related topatient safety in Nyai Ageng Pinatih Hospital, Gresik, and thiscondition was incompatible with the hospital mission to providehealth care professionally and safely. The objective was toimprove the performance of patient safety team at motherchildhospital, Nyai Ageng Pinatih Gresik based on the SixGoals International ...

  13. NASA Technical Interchange Meeting (TIM): Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box

    Science.gov (United States)

    ONeil, D. A.; Craig, D. A.; Christensen, C. B.; Gresham, E. C.

    2005-01-01

    The objective of this Technical Interchange Meeting was to increase the quantity and quality of technical, cost, and programmatic data used to model the impact of investing in different technologies. The focus of this meeting was the Technology Tool Box (TTB), a database of performance, operations, and programmatic parameters provided by technologists and used by systems engineers. The TTB is the data repository used by a system of models known as the Advanced Technology Lifecycle Analysis System (ATLAS). This report describes the result of the November meeting, and also provides background information on ATLAS and the TTB.

  14. Komitmen Sebagai Mediator Pengaruh Iklim Inovatif Dan Kecocokan Individu‐Tim Terhadap Kinerja

    OpenAIRE

    Sugiyanto, -

    2009-01-01

    In the long term, the purpose of the research is to build an understanding of the organizational commitment as an important mediator of the effects of various antecedents on performance. The commitment as a mediator has been studied in various levels of workplace: Low, medium, and high technologies. The current study tested a theoretical model of the components of organizational commitment as mediators, innovative climate and person‐team fit as antecedents, whereas its consequence was perform...

  15. Komitmen Sebagai Mediator Pengaruh Iklim Inovatif dan Kecocokan Individu‐Tim Terhadap Kinerja

    OpenAIRE

    Sugiyanto, -

    2015-01-01

    In the long term, the purpose of the research is to build an understanding of the organizational commitment as an important mediator of the effects of various antecedents on performance. The commitment as a mediator has been studied in various levels of workplace: Low, medium, and high technologies. The current study tested a theoretical model of the components of organizational commitment as mediators, innovative climate and person‐team fit as antecedents, whereas its consequence...

  16. Komitmen Sebagai Mediator Pengaruh Iklim Inovatif dan Kecocokan Individu‐Tim Terhadap Kinerja

    Directory of Open Access Journals (Sweden)

    - Sugiyanto

    2015-11-01

    point scale response ranging from 1 (not very important at all or strongly disagree to 5 (very important or strongly agree. Respondents were 203 university students. Data was analyzed using hierarchical multiple regression analyses.Results showed that the three components of organizational commitment were not significant mediator of the effects of innovative climate and person‐team fit on performance. Theoretical and methodological rinterpretations were discussed regarding the next designs of study.

  17. Analisis Pengaruh Kekuasaan dan Kemampuan Individu Anggota Tim (Studi Pada Pengaruh Keputusan Pembelian Batubara di Indonesia)

    OpenAIRE

    Sukesi Sukesi; Ario Agus

    2010-01-01

    Research on “organizational purchase behavior” is less developed compared to research on “consumer purchase behavior” due to the difficulty to get data from industries and organizational purchase behavior is influenced by more factors than consumer purchase behavior. Because of these reasons not many people willing to take a research on organizational purchase behavior. Some researchers who have studied organizational purchase behavior, most of them only emphasize on: purchase process, depart...

  18. Komunikasi Persuasif Tim Adiwiyata Sdn 6 Pekanbaru dalam Mewujudkan Sekolah Adiwiyata

    OpenAIRE

    Saputri, Mayang; Awza, Rusmadi

    2016-01-01

    Adiwiyata program is a program that implemented in school to actualize caring attitude and environment cultured on student. This program launched for the first time on 2006 by government through ministry of environment. SDN 6 Pekanbaru was success achieve three Adiwiyata awards in just two years period.AdiwiyataTeam running this program by using persuasive communication toward students by giving encouragement and example of impelementationabout caring attitude and cultured environment. This r...

  19. HUBUNGAN GAYA KEPEMIMPINAN TRANSFORMASIONAL TIM PEMBINA LBD (LOCAL BUSINESS DEVELOPMENT DENGAN SIKAP TERHADAP PELATIHAN LBD

    Directory of Open Access Journals (Sweden)

    Efa Yuliza

    2017-10-01

    Full Text Available Attitude is a component that consists of cognitive, affective and psychomotor. Formation and attitude change is determined by internal and external factors of the individual. One of the external factors that influence the attitudes of participants towards the training LBD is a transformational leadership style LBD team builder. Transformational leadership style is the way shown by superiors to subordinates within the framework of the provision of information through the encouragement and support. Support subordinates to think of new and better ways of working, caring, and emphasized the importance of values and beliefs in influencing subordinates. This paper aimed to explore the relationship between transformational leadership of LBD team (Local Business Development with the attitude to training LBD and the LBD participants who are around the area of operation of PT. CPI, Bengkalis.

  20. Calcium isotope measurement by combined HR-MC-ICPMS and TIMS

    DEFF Research Database (Denmark)

    Schiller, Martin; Paton, Chad; Bizzarro, Martin

    2012-01-01

    studies demonstrate that it is possible to measure the mass-dependent Ca isotope composition of terrestrial materials using HR-MC-ICPMS with an external reproducibility comparable to that typically obtained with double spike TIMS techniques. The resolution of the mass-independent 43Ca, 46Ca and 48Ca data...

  1. Evaluasi Kinerja KKIP Dalam Kerjasama Republik Indonesia-Korea Selatan Pada Pembangunan Kapal Selam Untuk Mendukung Ketahanan Alutsista TNI Angkatan Laut

    Directory of Open Access Journals (Sweden)

    Tunggul Prasetyo

    2017-04-01

    Full Text Available ABSTRACT This study was aimed to knew and analyzed the implementation of the cooperation between Republik Indonesia and South Korea in the construction of submarines ,to the Navy defense equipment resilience. The method used by the researchers in this study was a qualitative descriptive method. Data collection techniques used three techniques, in-depth interviews, observation, library and documentation. Objects in this study that the parties involved in the cooperation Indonesia South Korea in the construction of submarines, especially the executive team officials Defence Industry Policy Committee (KKIP. The results showed that in the implementation of cooperation Indonesia South Korea in the construction of the submarine still lacks the strength of its bargaining Indonesian government, especially KKIP and Defense industry involved in this cooperation program. This was indicated by the presence of the technology transfer process was still below of 85 % as a basis for accelerating the revitalization of the defense industry in achieving the navy defense resilience ABSTRAK Penelitian ini bertujuan untuk mengetahui dan menganalisis pelaksanaan kerjasama yang dilaksanakan indonesia-Korea Selatan dalam Pembangunan Kapal Selam dan mengevaluasi kerjasama Indonesia Korea selatan dalam pembangunan kapal selam terhadap ketahanan alutsista TNI AL. Metode yang digunakan dalam penelitian adalah metode deskriptif kualitatif. Teknik pengumpulan data menggunakan tiga teknik, yaitu wawancara mendalam, observasi, kepustakaan, serta studi dokumentasi. Objek dalam penelitian ini yaitu para pihak yang terlibat dalam kerjasama Indonesia Korea selatan dalam pembangunan kapal selam, khususnya para pejabat tim pelaksana Komite Kebijakan Industri Pertahanan (KKIP. Hasil penelitian menunjukkan bahwa dalam pelaksanaan kerjasama indonesia Korea selatan dalam pembangunan kapal selam memiliki kekurangan berupa kekuatan tawar menawar pemerintahan Indonesia, khususnya KKIP

  2. Kajian Perkuatan Struktur Gedung yang Disesuaikan dengan Sni Gempa 03-1726-2012 Kota Semarang Studi Kasus Gedung Kuliah Utama Fakultas Teknik Universitas Diponegoro

    OpenAIRE

    Satrio, Bayu Dwi; Pratama, Gema Putra; Tudjono, Sri; Wibowo, Hardi

    2016-01-01

    The Main Lecture Building of Engineering Faculty of Diponegoro University construction process start form June 2010 and be expected to finish at November 2010 but until October 2015 this building can not used as it planned because the construction process have some trouble. Design of this building still use the old guidence that is Earthquake SNI 03-1726-2002. This day that guidence has been updated become Earthquake SNI 03-1726-2012. Because of that this building need to studied so the build...

  3. Hubungan Tingkat Pengetahuan dengan Pola Konsumsi Buah dan Sayur pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Angkatan 2014 di Medan Tahun 2015

    OpenAIRE

    Manullang, Ruth Mutiara Angelina

    2016-01-01

    Fruit and vegetables consumption among adolescent was still less than WHO recommendation of 400 gram per day. Lack of fruit and vegetable consumption can lead to body vitamine, mineral, antioxidant, and dietary fiber deficiency. Furthermore low fruit and vegetable consumption in adolescent can lead to various degenerative diseases in adulthood and elder. This study aims to determine the relationship level of knowledge with the fruit and vegetable consumption pattern on Medical School of North...

  4. Analisis Pengaruh Citra Merek dan Citra Perusahaan Terhadap Keputusan Pembelian Kartu IM3 Pada Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Sumatera Utara

    OpenAIRE

    Riri Wardhanni

    2015-01-01

    The objective of this research is to study and analyze the influence of brand image and corporate image to the buying decision of IM3 to the college student of economic and business faculty of North Sumatera University. This research is associative study. This research applies quantitative approach. The data was collected through two data source, i.e. primary and secondary data. The primary data was obtained directly from the research subject using questionnaire that distributed to the respon...

  5. Pemilihan Karir Perempuan Sebagai Akuntan Pendidik Dalam Perspektif Simone de Beauvoir: Studi Kasus pada Akuntan Pendidik Jurusan Akuntansi Fakultas Ekonomi dan Bisnis Universitas Tanjungpura Pontianak

    Directory of Open Access Journals (Sweden)

    Soraya Soraya

    2016-12-01

    Full Text Available Educators accountants have a significant role in the education world. This paper aims to gain a better understanding and in-depth information on the aspects that make up the women’s options for a career as an accountant educators. Further goal is to explaining the selection of women’s careers as educators accountant in perspective Simone de Beauvoir. This paper used a qualitative approach. Researcher also conducted narrative researchers through in-depth interviews to the 7 (seven women in the Department of Accounting Faculty of Economics and Business, University of Tanjungpura Pontianak. From the interviews, founded are six aspects that make up the women’s options for a career as an accountant educators. These six aspect are the job opportunity (vacancies, time work flexibility, family background, meeting many people (students, childhood dream, and knowledge sharing. From these six aspect of the career choice, job opportunity (vacancies and time flexibility aspect are the most disclosed widely aspect in choosing a career as an accountant educators. In addition, Simone de Beauvoir perspective can not explain the selection of women’s careers as educators accountant.

  6. Analisis Faktor-Faktor Yang Mempengaruhi Keputusan Konsumen Pada Pembelian Produk- Produk Online Shop (Studi Pada Mahasiswa-Mahasiswi Fakultas Ilmu Sosial Dan Ilmu Politik Universitas Sumatera Utara)

    OpenAIRE

    Sari, Putri Eka

    2015-01-01

    This study was motivated by the development of technology and media marketing is a business Online. These developments are changing the behavior of people who originally shopped to traditional markets into online shopping so it is necessary to know the factors that influence the behavior of consumers to buy products online. The purpose of this study was to analyze the effect of prices, confidence, advertising, and product quality on purchasing decisions on products being sold on the online...

  7. Pengaruh Merokok Terhadap PH Dan Aktivitas Enzim Amilase Air Liur Pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara (FK USU) Angkatan 2007.

    OpenAIRE

    Nazira, Syarifah

    2011-01-01

    Smoking causes several changes in human body parts, including saliva. Literature study shows that smoking can turn salivary pH becomes more acidic and acidic pH causes enzyme that belongs to it works improperly. The goal of this research is to identify the effect of smoking to the salivary pH and the relationship between this salivary pH with its amylase enzyme activity This cross-sectional study was conducted in analytical descriptive method, with 32 respondents were chosen, every each of th...

  8. Fitur Seleksi Forward Selection Untuk Menetukan Atribut Yang Berpengaruh Pada Klasifikasi Kelulusan Mahasiswa Fakultas Ilmu Komputer UNAKI Semarang Menggunakan Algoritma Naive Bayes

    Directory of Open Access Journals (Sweden)

    Mohamad Fajarianditya Nugroho

    2017-09-01

    Full Text Available Data mining dalam dunia pendidikan dikenal dengan Educational Data Mining. EDM mengembangkan metode untuk menggali data pendidikan dan menggunakan metode tersebut untuk lebih memahami siswa. EDM dapat membantu pendidik untuk menganalisis cara belajar, mendeteksi mahasiswa yang memerlukan dukungan dan memprediksi kinerja mahasiswa. Perguruan tinggi perlu melakukan prediksi perilaku mahasiswa dan peringatan dini untuk mencegah secara dini kegagalan akademik mahasiswa. Naive Bayes memanfaatkan fungsi seleksi fitur dari Forward Selection untuk pemilihan atribut data dengan karakteristik data itu sendiri, dan meningkatkan ketepatan klasifikasi Naïve Bayes. Forward Selection berbasis Naive Bayes lebih akurat dan efektif dalam mengklasifikasikan status kelulusan mahasiswa dengan hasil akurasi 97,14% dan termasuk dalam kategori “excellent classification” dan memperoleh atribut yang berpengaruh yaitu: status pekerjaan dan IPK semester 4

  9. Hubungan Self Regulation Dengan Self Determination (Studi Pada Mahasiswa Aktif Semester Genap 2013/2014, Ipk ≤ 2.75, Fakultas Psikologi, Universitas X, Jakarta)

    OpenAIRE

    Rozali, Yuli Azmi

    2014-01-01

    Students who are motivated towards their task, will be able to perform its task properly and independently, as well as having a high level of creativity in their work, so that students are expected to produce satisfactory academic achievement. However, students with lower educational achievement measured in GPA, a student who is suspected of having a low self-sufficiency. They are not motivated to follow the teaching and learning process in higher education. This study is a quantitative non-e...

  10. STUDI KASUS PEMANFAATAN E-LEARNING SEBAGAI SALAH SATU SARANA YANG MENDUKUNG PEMBELAJARAN DI FAKULTAS TEKNOLOGI INFORMASI DAN KOMUNIKASI UNIVERSITAS SEMARANG

    Directory of Open Access Journals (Sweden)

    Maya Rini Handayani

    2011-01-01

    Full Text Available Seiring dengan perkembangan Teknologi Informasi (TI yang semakin pesat, kebutuhan akan suatu konsep dan mekanisme belajar mengajar (pendidikan berbasis TI menjadi tidak terelakkan lagi. Konsep yang kemudian terkenal dengan sebutan e-Learning ini membawa pengaruh terjadinya proses transformasi pendidikan konvensional ke dalam bentuk digital, baik secara isi (contents dan sistemnya. Sistem e-Learning mutlak diperlukan untuk mengantisipasi perkembangan jaman dengan dukungan Teknologi Informasi dimana semua menuju ke era digital, baik mekanisme maupun konten. Pengembangan sistem e-Learning harus didahului dengan melakukan analisa terhadap kebutuhan dari pengguna (user needs. Sesuai dengan paradigma rekayasa sistem dan perangkat lunak, kebutuhan dari pengguna ini memiliki kedudukan tertinggi, dan merupakan dasar kreasi dan kerja pengembang. Agar penelitian ini dapat memberikan hasil yang baik, maka penulisan laporannya menggunakan berbagai macam data, keterangan data, serta informasi penting yang diperoleh dari berbagai sumber, didasarkan pada (1 data primer, yaitu data yang diperoleh secara langsung dari obyek penelitian ( dosen dan mahasiswa , (2 data sekunder, yaitu data yang diperoleh dari buku-buku, literatur sebagai pelengkap dalam penyusunan laporan penelitian ini. Metode Studi Pustaka, yaitu metode pengumpulan data melalui pemahaman literatur maupun buku dan juga browsing internet sebagai acuan untuk menentukan landasan teori. Metode angket / kuesioner, yaitu pengumpulan data dengan membagikan kuesioner kepada para dosen dan mahasiswa di lingkungan FTIK USM

  11. Pengaruh Kemudahan Penggunaan Terhadap Kemanfaatan Pada Sikap Pengguna E-learning Survei Pada Mahasiswa Jurusan Administrasi Bisnis, Fakultas Ilmu Administrasi Universitas Brawijaya Malang Angkatan 2011

    OpenAIRE

    Aziz, Alfin Lutfi

    2013-01-01

    The research aims to: (1) influence ease of use e-learning on usefulness of e-learning. (2) influence ease of use on e-learning user attitudes (3) influence of usefulness on e-learning user attitudes. Researcher want to know how a person's attitude toward technology acceptance by using Technology Acceptance Model. This research type is explanation. that shows a causal relationship between research variables by testing hypotheses. Exogenous variable in this research is the ease of use of e-lea...

  12. Konsep Diri Mahasiswa dalam Media Sosial (Studi Deskriptif Kualitatif Konsep Diri Mahasiswa Ilmu Komunikasi Fakultas Ilmu Sosial dan Ilmu Politik Universitas Sumatera Utara dalam Media Sosial Instagram)

    OpenAIRE

    Silaen, Revina Rezeki

    2016-01-01

    The research entitled “Self Concept of College Students in Social Media”, where the social media is focused on Instagram. The research is done by doing interwiew with college students of Communication Science Department of Social Science and Politic Science Faculty, University of North Sumatera. Aims of this research are to know the self concept of student college in Instagram and factors that influence the positif self concept or negative self concept on using Instagram. As for theory that u...

  13. PENGARUH MODAL BUDAYA, TINGKAT PENDIDIKAN ORANG TUA DAN TINGKAT PENDAPATAN ORANG TUA TERHADAP PRESTASI AKADEMIK PADA MAHASISWA FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA

    Directory of Open Access Journals (Sweden)

    Henry Eryanto

    2013-03-01

    Full Text Available This research was aimed at describing the effect of cultural capital, education level of parents and income level of parents to academic achievement. In this research, the analysis use qualitative and quantitative. Qualitative analysis described in descriptive about cultural capital, education level of parents and income level of parents to academic achievement. The quantitative analysis used Logistic Regression. The Regression of research results show that: (1 cultural capital has a positive influence to academic achievement and the effect statistically significant. (2 education level of parents has a positive influence to academic achievement and the effect statistically significant. (3 income level of parents has a positive influence to academic achievement and the effect statistically significant.

  14. Hubungan Gaya Belajar dan Keterampilan Belajar dengan Hasil Belajar Mahasiswa Serta Implikasinya dalam Pelayanan Bimbingan dan Konseling di Fakultas Ilmu Pendidikan Universitas Negeri Padang

    Directory of Open Access Journals (Sweden)

    Triave Nuzila Zahri

    2017-08-01

    Full Text Available The learning process in university level is quite different from the former education levels so that the students need to be adapted to. The students, in fact, were still unaccustomed to the learning style, unserious and frequently absent from the class, did not do assignment as they were required, and did not submit the tasks on the time they were due. This research was intended to describe the students’ learning style and learning skill and its implication in Guidance and Counseling service. This research could be classified into descriptive study. The population of the research was 1021 students in the Faculty of Education of UNP. By using purposive random sampling technique and Taro Yamane formula, 287 students were taken as the sample. The instrument of the research was the scale of Likert model. The data obtained were analyzed by using percentage technique. The correlation between learning style and learning outcomes was tested by using Chi Square, and correlation between learning skill and learning outcomes was tested by using Spearman Rank Correlation.  The results of the research revealed that: (1 the learning style dominantly applied by the students of the Faculty of Education of UNP was visual learning style which was used by 49.13% students, (2 the learning skill of the students of the Faculty of Education of UNP was in average category (68.18%, (3 there was a significant correlation between learning style and learning outcomes, and (4 there was a significant correlation between learning skill and learning outcomes. The implication of these research findings toward Guidance and Counseling Service was it was necessary to cooperate with other related parties to optimize the students’ learning style, learning skill and  learning outcomes.

  15. Perbaikan Ergonomi Lingkungan Internal Perpustakaan Untuk Peningkatan Kenyamanan dan Performansi Kerja Pemustaka: Studi Kasus di Perpustakaan Jurusan Teknik Mesin dan Industri Fakultas Teknik UGM

    Directory of Open Access Journals (Sweden)

    Rita Yulianti

    2016-09-01

    Full Text Available The important factor to create conducive library room is to provide room with various conditions. Those conditions are sufficient lighting intensity, sufficient room temperature, low noise, ergonomic design facilities to support the learning condition for library user. The goal of this research is to ergonomically evaluate library internal environment of Machine and Industrial Engineering Department at Engineering Faculty UGM. The evaluation consists of lighting, temperature, humidity, noise factor, working posture and comfort level of the library user. The result will show whether this library has provided comfort and ergonomic facilities for the library user to study. The data collected shows: lighting condition, maximum lighting in the library is 149.9 lx which is below the recommended standard; the maximum temperature is 24.97˚C which is good; humidity level is 63-66% which is slightly above the standard; and the noise factor is below the Limit Value (70 dBA namely 59.24 dBA. The library user working posture measures through three students with tall, average and small categories who working with notebook. The RULA analysis shows the tall student is at action level 6 which indicates the need for investigation and the reparation immediately. The average and small student shows action level 3 which indicates sustainable investigation and reparation possibility. The questionnaire collected from 92 samples. The result shows 63.04% respondents choose high comfort, 26.09% respondent shows average comfort, while 10.87% choose low comfort of the library room.

  16. Analisis Faktor Pembentuk Keputusan Pemilihan Perguruan Tinggi Swasta Universitas Telkom (Studi Pada Mahasiswa Prodi S1 Administrasi Bisnis Fakultas Komunikasi Dan Bisnis Universitas Telkom Angkatan 2016

    Directory of Open Access Journals (Sweden)

    Mahendra Fakhri

    2017-07-01

    Full Text Available In Indonesian, public university and private university compete so tightly to create qualified graduates. Beside that, they compete to provide best educational services to get more students. This study aimed to analyze dominant factors that forming student decision in choosing Telkom University study program S1 Business Administration.The type of this study is descriptive research with nonprobability sampling and simple random sampling technique. Questionnaires were distributed to 100 samples of Business Administration’s students batch 2016. This research used variable such as: friends attending college, influence of parents, influence of friends, influence of other individuals, location, academic program, academic reputation, educational facilities, costs, available of financial aid, employment opportunities, advertising, HEI’s representative and visit campus.Based on analysis, it was found 5 new factors such as college’s  image, college promotion, influence of parents, influence of friends and college’s location. College’s image factor has the biggest variances value such as 29,15% in forming choise decision of Telkom University Prodi S1 Business Administration as a private college.Keywords: factor analysis, students choice decision of private college, college’s image.

  17. Pengaruh Rubrik Fashion Majalah Gogirl! terhadap Perilaku Meniru Trend Fashion di Kalangan Mahasiswi Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

    OpenAIRE

    ", Suyanto; Ardilla, Sucie Nella

    2015-01-01

    Most of university liberate their students to dress in the collage. Of course with the applicable rules. But along with times many changes happened in dress. We can found a lot of trends that look unusual and eccentric. On the other hand, Fashion magazine looks more incentives to providing the latest fashion trends. Each magazine provides its own fashion style according to the age category in that magazine. And the GoGirl! magazines, included in the category of magazines that read by the stud...

  18. EVALUASI SIMPANGAN STRUKTUR AKIBAT PENAMBAHAN LANTAI DENGAN METODE ANALISIS STATIK DAN DINAMIK RESPONSE SPECTRUM (Studi Kasus : Pembangunan Gedung Dekanat Fakultas Teknik UNTIRTA

    Directory of Open Access Journals (Sweden)

    Soelarso Soelarso

    2017-07-01

    Full Text Available The Advancement of Science and Technology made Indonesians increasingly concerned about education at the university so that the increasing of students must be balanced with the development of education building infrastructure. In 2015, have been built 3 floors which functioned as offices for Dean Faculty of Engineering Untirta, but in the process of implementation is done re-design with the addition of 3 floors above it to meet space requirement at the Faculty of Engineering Untirta. This research was conducted to re-analyze the deflection of structure building in order to know the deflection of structures due to the addition of load and the effect of earthquake force, so that can be evaluated to plan the addition of floor as much as 3 floors in Faculty of Engineering Untirta building structure. The analytical method used are the equivalent static analysis and dynamic response spectrum analysis using the computer program Extended Three dimensional Analysis Building System (ETABS. Resulted from 3D model analysis with the addition of 3 floors, the behavior of structures in the modes 1,2 and 3 respectively happened translations X direction, Y direction and Z axis rotation. Base shear force that occurred for 1.549.45 kN at X direction and 1.581,06 kN at Y direction. Maximum deflection that happened at 298,65 mm due to earthquake load X direction, 249,59 mm due to earthquake load Y direction. The deflection value has exceeded the allowable deflection limit of 186 mm, so that the existing structures cannot resist against the working load  due to the addition of the floor according to the design standard of SNI 03-1726-2012.

  19. Pengaruh Gaya Hidup, Harga, Dan Kelompok Referensi Terhadap Keputusan Pembelian Samsung Smartphone Pada Mahasiswa/I Fakultas Ekonomi Universitas Sumatera Utara

    OpenAIRE

    Tarigan, Azalea Azura

    2015-01-01

    This research is to study and analyze bertujuuan Lifestyle (X1), price (X2), and the Reference Group (X3) on Purchase Decision Samsung Smartphone the Student Faculty of Economics and Business University Of North Sumatera. The sampling technique using puposive Sampling, which samples were selected based on specific criteria. The population in this study were students of the Faculty of Economics and Business University of North Sumatra active college which has used Samsung Smartphone of the yea...

  20. Pengukuran Tingkat Kesadaran Merek (Brand Awareness) pada Motor Honda (Studi Kasus pada Mahasiswa Fakultas Ilmu Sosia dan Ilmu Politik Universitas Riau)

    OpenAIRE

    Permadi, Giovani; Heriyanto, Meyzi

    2016-01-01

    This study was conducted to test the Brand Awareness Level Measurement (Brand Awareness) At Honda Motor (Case study of social, Faculty of Science and Political Science, University of Riau). Brand awareness measurement can be done by characterizing the four elements, namely, top of mind, brand recall, brand recognition, unaware of the brand. The sampling method used is convenience sampling that samples can be found easily, as many as 100 respondents.Analysis technique used is descriptive analy...

  1. Efektivitas Hand Sanitizer Dibanding Mencuci Tangan Memakai Sabun dalam Menjaga Kebersihan Tangan pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Angkatan 2012

    OpenAIRE

    Akim, Muhammad

    2015-01-01

    Hand washing is a simple way to remove impurities and minimize germs on hand with water flowing and can be done by adding certain ingredients. Hand washing can prevent more than 1 million deaths per year due to diarrhea problems, whilst hand washing with soap can reduce diarrhea until 47 %. The goals is to determine the effectiveness of hand sanitizing compared to hand washing with soap in maintaining hand hygiene of students in Faculty of Medicine, North Sumatera University, class of 2012...

  2. Pengaruh Kualitas Produk, Harga Dan Nilai Pelanggan Terhadap Kepuasan Pelanggan Handphone Blackberry (Studi Pada Mahasiswa Fakultas Ilmu Sosial Dan Ilmu Politik Universitas Diponegoro Semarang)

    OpenAIRE

    Widyawati, Suci; Farida, Naili; Wijayanto, Andi

    2013-01-01

    BlackBerry smartphone is one of the leading products in Indonesia. BlackBerry has a high market share compared with other brands of smartphone, but BlackBerry users consumer satisfaction index has declined. It is very influential on consumer loyalty to BlackBerry mobile phone. This study aimed to determine the effect of product quality, price and customer value on customer satisfaction BlackBerry mobile phone. Population in this research is a BlackBerry mobile phone users in FISIP UNDIP Semar...

  3. Peningkatan Kemahiran Membaca Intensif Melalui Teknik Pembelajaran SQ4-R (Penelitian Tindakan Kelas Pada Mahsiswa Jurusan Pendndidikan Bahasa Arab Fakultas Tarbiyah Dan Keguruan IAIN Raden Intan Lampung)

    OpenAIRE

    erlina, Erlina

    2014-01-01

    The aim of this research is to increase the students‘ ability in the sixth semester of the Department of Arabic Language Education Academic 2013-2014 in Intensive reading skill and understanding Arabic texts through the application of SQ4-R learning technique.This research is an action research and qualitative approach. Methods for data gathering: observation, interview, portofolio, reading comprehension test, and field record. Data were analyzed qualitatively by reducing, presenting and with...

  4. Sifat Biologi Tanah Mineral Masam Dystrudepts Di Areal Piringan Kelapa Sawit Yang Diaplikasi Mulsa Organik Mucuna Bracteata Di Lahan Percobaan Fakultas Pertanian, Universitas Riau

    OpenAIRE

    Zahara, Fitri; ', wawan; ', Wardati

    2015-01-01

    The objectives of this research to determine the soil biological properties on the acidic mineral soil Dystrudepts in the area of disc palm oil applied of organic mulch Mucuna bracteata in the experimental garden of Agriculture Faculty, Riau University. Analysis of the soil biological was conducted in the Soil Laboratory of Agriculture Faculty, Riau University, in October 2014 to February 2015. Application of mulch organic M. bracteata used purposive random sampling method which consisting of...

  5. HAMBATAN DALAM MENDAPATKAN PENGALAMAN BELAJAR KLINIS PADA KEPANITERAAN KLINIK DI UNIT GAWAT DARURAT (UGD BAGI MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS PADANG

    Directory of Open Access Journals (Sweden)

    Hardisman Hardisman

    2009-05-01

    Full Text Available AbstrakPenatalaksanaan gawat darurat merupakan kompetensi yang vital dan harus dimiliki oleh setiap dokter. Selain itu, sejak tahun ajaran 2007/2008 pada tahapan klinik, FK-UNAND melakukan penataan lebih baik pada sistim kepaniteraan. Oleh karea itu perlu dilihat apakah peroses pendidikan di UGD juga telah memberikan pengalaman belajar klinis yang optimal? Serta apa hambatan dalam mendapatkan pengalaman klinis tersebut?.Desain penelitian ini adalah cross sectional study dan dilaksanakan pada bulan September 2007 - Maret 2008. Instrument pengumpulan data adalah kuisioner terstruktur dan sebagian besar menggunakan sistim skala. Populasi dan sampel penelitian ini adalah seluruh mahasiswa yang sedang menjalankan rotasi kepaniteraan klinik di Instalasi Gawat darurat (IGD yang diambil pada dua siklus. Data-data kuantitatif dianalisa secara deskriptif. Untuk melihat bagaimana perbedaan gender dalam mendapatkan pengalaman belajar klinis dianalisa secara statistik (t-test.Kesempatan belajar memperoleh pengalaman klinis oleh mahasiswa mencapai skala 3 lebih (sedang dan tidak ada perbedaan antara laki-laki dan perempuan (p>0,05. Secara sepesifik, kesempatan melakukan tindakan penatalaksanaan jalan nafas (airway management merupakan kesempatan yang paling jarang didapatkan (skala 2,11. Kesempatan melakukan penatalaksanaan dan menjahit luka serta melakukan injeksi cukup sering, dengan skala 4,05 dan 4,25. Hambatan utama dalam memperoleh pengalaman klinis adalah karena jumlah pasein yang kurang (39,7% kurangnya bimbingan (32,9% dan sikap penerimaan atau penolakan dari staf perawat (16,4%.Kesempatan mendapatkan pengalaman dan pencapaian kompetensi klinis mahasiswa di UGD belumlah optimal. Hal ini dipengaruhi oleh beberapa hambatan seperti jumlah pasien dan bimbingan yang kurang serta sikap penerimaan dan kerjasama staf perawat.Kata Kunci: Pengalaman belajar klinis dan pendidikan kedokteran.ARTIKEL PENELITIAN9AbstractClinical competency in management of emergency cases is one of the very important competencies of medical graduate. Therefore, this important to recognize, does the clinical clerkship in Emergency Department (ED provide adequate learning for medical students?.A cross sectional study was conducted between September 2007 and March 2008 in Faculty of Medicine of Andalas University. The data was gathered by structured questionnaire which majority of the questions are scale system. Respondents of the study are the students who are doing clinical attachment in ED when the study being conducted (two groups of rotation with total 110 students. Majority of the quantitative data has been analysed descriptively. To investigate difference clinical learning experiences and competencies between male and female students has been used statistical analysis of t-test.In average, the students obtain clinical learning experiences in medium level (above scale 3, in which there is no difference between male and female (p>0.05. Specifically, experience in conducting airway management is the lowest scale (2.11. Most of the students (66.4% encounter barriers to gain clinical experience. They feel that the main barriers in obtaining clinical learning experiences are limited number of the patients (39.7%, inadequate supervision (32.9% and nursing staff attitude (16.4%.The students do not get optimal clinical learning experience and competencies in ED. These are influenced by limited number of patients, inadequate supervision and attitude of nursing staffs.Keywords:Clinical learning experiences and and medical education.

  6. Student Entrepreneurship, Prospect Or Problems? (Identifikas Jenis dan Permasalahan yang Dihadapi Mahasiswa Fakultas Ekonomi Universitas Katolik Parahyangan dalam Memulai dan Menjalankan Bisnis)

    OpenAIRE

    Fernando, Fernando; Wahyu, Vincentia

    2015-01-01

    People without any college education who start a business have a greater chance of failing than people with one or more years of college education (Lussier & Halabi, 2008). Lussier & Halabi research at Chile concludethat study experience at higher education institution is significant for their success when they starting up business.Parahyangan Catholic University (also known as UNPAR) is one the oldest private university in Indonesia.UNPAR established in 1955, and its first Faculty is...

  7. TINGKAT KEPUASAN MAHASISWA TERHADAP LAYANAN AKADEMIK DOSEN PENDIDIKAN AGAMA ISLAM (PENELITIAN PADA MAHASISWA SEMESTER II FAKULTAS ILMU PENDIDIKAN UNIVERSITAS NEGERI SEMARANG

    Directory of Open Access Journals (Sweden)

    Ilyas Ilyas

    2014-02-01

    Full Text Available One of the subjects who had a goal guarding behavior in the learning process of students on campus is MKU (General Courses. And one of the common subjects are Islamic Education (PAI. With subjects such PAI sincerely hope college students to be able to color the character better. Hope is certainly not to blame, but please note that in the process of PAI college is not easy to carry out the mandate in order to make students become better morals. Because the process involves a lot of things, as in educational theory that there are several factors that affect learning, including students, teachers, objectives, content, and the environment. The results of this study indicate that some of the services that it is considered satisfactory academic student in university classes FIP UNNES PAI is mastery of the material by lecturers and professors appearance and acceptance of lecturers to students. Services that still needs improvement is the presence of a lecturer at the college, faculty understanding of the condition of the course students conformity with the plan of activities, evaluation and feedback, availability syllabus and plan learning activities and the provision of reference books.

  8. Pengaruh Kepercayaan, Kemudahan, dan Kualitas Informasi Terhadap Keputusan Pembelian Secara Online Di Situs Lazada.co.id Pada Mahasiswa/I Fakultas Ekonomi Dan Bisnis USU

    OpenAIRE

    Sari, Maya Puspa

    2015-01-01

    The purpose of this study was to determine and analyze the influence of the trust, easy to use, and information quality on online buying decision in lazada.co.id of the Students at Faculty of Economics and Business University of North Sumatera. This research is associative causal research aimed to analyze the relationship between one variable with another variable or how a variable affecting other variables. The population in this study is an active student who ever made a online shopping who...

  9. Ekspektasi Rencana Masa Depan Mahasiswa Program Pendidikan Kepaniteraan Dokter (P3d Tahap Dua Fakultas Kedokteran Universitas Padjadjaran Angkatan 2000–2001

    Directory of Open Access Journals (Sweden)

    Sharon Gondodiputro

    2009-03-01

    Full Text Available The need of doctors which worked at the primary health centers in West Java was high. Faculty of Medicine Universitas Padjadjaran (FKUP had the responsibility to fulfill the scarcity of doctors in West Java. The aim of this study was to know the expectation of work location of medical doctors “ to be “so that the faculty could develop the medical education currículum that fulfill the community needs. This study was a cross sectional study with 156 final semester medical students year 2000 – 2001, using questionnaire and analyzed by frequency distribution. The results were the contribution of FKUP to fulfill the health workforce in West Java is only 30 – 40% .Most of the students planned to work first (75.64%, but after that, most of them (97.46% planned to continue their study especially for specialization (81.69%. This situation had an negative impact on the continuity of health programs for the community (primary care, because there would be always new doctors who would work at the primary health centres. The most interested specializations were internal medicine, surgery, pediatrics, obstetric-gynaecology. On the other hand, students who chose master program, were interested to study hospital administration/management and health management, health law and health economics. The reasons they wanted to work first were mostly to get experiences (35.18% and to collect money for further study (32.16%. Most of the respondents planned to work at primary health center 26.72% mostly puskesmas and secondary health center (20.61%. Other choices were working at Industries and Non Governmental Organizations. Conclusions: FKUP gives more opportunity for students from West Java studying at FKUP so that in the future they could fulfill the scarcity of doctors in West Java. Secondly medical curriculum must be developed so that the doctors “to be” are more interested to work at the primary health centers permanently.

  10. STRATEGI PENGEMBANGAN INSTITUSI PELAYANAN KESEHATAN GIGI DENGAN PENDEKATAN RISET OPERASIONAL (Suatu Kajian Terhadap Perencanaan Strategik Pengembangan Klinik Gigi Akadmeik Fakultas Kedokteran Gigi Universitas Trisakti Tahun 2000 - 2004

    Directory of Open Access Journals (Sweden)

    Tri Erri Astoeti

    2015-08-01

    Full Text Available The purpose of this study was to determine the best strategy to develop dental health institution. This study used operational research method with qualitative and quantitative analysis and aided by forecasting technique such as Time Series Forecasting from QSB+ at Academic Dental Clinic (KGA FKG Usakti. The research was done in 3 (three stages. Stage 1 (input stage covered the external and internal analysis of KGS FKG Usakti through a Consensus Decision Making Group (CDMG. In stage II (matching stage the result of stage I was analyzed using Internal-External (IE and SWOT matrix. The best strategy priorities was determined in the last stage (decision stage using the QPSM matrix. In the matching stage, CDMG agreed that KGA FKG Usakti is at Grow and Build position which consisted of intensive strategies (market penetration, market development, product development, and integrative strategies (forward, backward, horizontal integration. As conclusion, KGA FKG Usakti has a significant market potential and relatively strong internal capability, in a competitive atmosphere. The position of grow and build indicates that a quality improvement is still needed. All selected strategies shall be operated and reorganized following three different structures of increasing sales/marketing, operations and performances, and supporting infrastructure.

  11. PENGARUH KESIAPAN BELAJAR, MOTIVASI BELAJAR, FASILITAS BELAJAR DAN LINGKUNGAN TEMAN SEBAYA TERHADAP KETERAMPILAN MENGETIK MAHASISWA PROGRAM PENDIDIKAN ADMINISTRASI PERKANTORAN FAKULTAS EKONOMI UNIVERSITAS NEGERI SEMARANG

    Directory of Open Access Journals (Sweden)

    Dyah Ayu Ratnaningtyas

    2014-06-01

    Full Text Available Tujuan dari penelitian ini yaitu untuk mengetahui adakah pengaruh kesiapan belajar, motivasi belajar, fasilitas belajar dan lingkungan teman sebaya terhadap keterampilan mengetik mahasiswa Pendidikan Administrasi Perkantoran secara simultan maupun parsial. Populasi yang diteliti dalam penelitian ini merupakan mahasiswa Pendidikan Administrasi Perkantoran angkatan tahun 2011 yang telah mengikuti mata kuliah mengetik manual I, mengetik manual II dan mengetik elektronik sebanyak 115 orang. Pengumpulan data dilakukan dengan cara kuesioner, tes dan dokumentasi. Teknik analisis data menggunakan analisis deskriptif dan analisis regresi berganda. Hasil dari analisis regresi ganda penelitian ini yaitu Y = -1.047 + 0.037X1 +0.106X2 + 0.055X3 + 0.093X4. Ada pengaruh secara simultan sebesar 70.6%, sedangkan pengaruh secara parsial kesiapan belajar sebesar 4.162%, motivasi belajar sebesar 16%, fasilitas belajar sebesar 10.3%, dan lingkungan teman sebaya sebesar 11.9%. The purpose of this research is to find out whether is there any influence of readiness to learn, learning motivation, learning facilities and peers environment towards students of office administration either simultaneously or partially. The population in this research is 115 students of office administration year 2011 who have finished their study on manual typing I, manual typing II and electronic typing. The data was collected using questioner, test and documentations. The data analysis technique used in this research was descriptive analysis and multiple regression analysis. The result of the multiple regression analysis is Y = -1.047 + 0.037 + 0.106 + 0.055 + 0.093 . There is a simultaneous influence as much as 70.6%, whereas partially the influence of readiness to learn as much as 4.162%, learning motivation 16%, learning facilities 10.3% and peers environment 11.9%.

  12. Sistem Akuntansi Pengelolaan Dana Desa

    Directory of Open Access Journals (Sweden)

    Ari Kuncara Widagdo

    2016-10-01

    Pada tahun 2014, pemerintah dan DPR mengesahkan Undang-Undang Nomor 6 Tahun 2014 mengatur tentang hak dan kewajiban desa. Hal pokok dalam UU adalah adanya alokasi dana desa yang cukup besar untuk setiap desa. Pengesahan UU ini menimbulkan polemik dimasyarakat. Beberapa pihak menyambut gembira terbitnya UU tersebut karena adanya dana desa akan menjadikan desa sebagai pusat pembangunan. Sebaliknya, beberapa pihak berpendapat bahwa dana desa yang akan dialokasikan kepada desa akan menimbulkan potensi korupsi yang dilakukan aparat desa. Sebagai tindak lanjut UU tersebut, pemerintah juga telah menerbitkan Peraturan Menteri Dalam Negeri No. 113/2015 tentang Pengelolaan Keuangan Desa yang menjadi panduan bagi pemerintah desa dalam penata kelolaan keuangan desa. Oleh karena itu, pengabdian masyarakat ini bertujuan untuk  mengetahui berbagai permasalahan yang dialami desa terkait pengelolaan dana desa dan memberikan bimbingan dan pelatihan pengelolaan dana desa. Pengabdian di lakukan di Desa Kismoyoso dan Desa Giriroto Kecamatan Ngemplak Boyolali. Pada tahap awal pengabdian dilakukan observasi dan diskusi secara langsung dengan Kepala Desa Kismoyoso dan  Giriroto. Hal ini  bertujuan untuk memahami lebih dalam permasalahan kedua desa terkait pengelolaan dana desa. Hasil observasi dan diskusi menunjukkan bahwa permasalahan utama yang timbul adalah rendahnya pengetahuan dari kepala desa di kedua desa tersebut berserta pelaksana teknis terkait pengelolaan keuangannya desa berdasarkan Permendagri No. 113/2015. Hal itu ditambah lagi dengan belum adanya tenaga pendamping dari Kabupaten Boyolali yang diturunkan untuk mendampingi di kedua desa tersebut. Tim pengabdian menganggap pelaporan keuangan dana desa secara komputer merupakan solusi untuk mengatasi kendala tersebut. Permendagri No. 113/2015 hanya mengatur  format-format pelaporan secara manual dan tidak mensyaratkan adanya komputerisasi dalam pelaporannya. Disisi lain,  teknologi informasi komputer (TIK telah semakin

  13. Analisa Beban Kerja Dengan Menggunakan Work Sampling Dan Nasa-tlx Untuk Menentukan Jumlah Operator (Studi Kasus: PT Xyz)

    OpenAIRE

    Ramadhan, Rahadian; Tama, Ishardita Pambudi; Efranto, Remba Yanuar

    2014-01-01

    PT. XYZ merupakan pabrik yang bergerak di bidang sandang. Dalam penelitian ini, metode yang digunakan adalah pengukuran beban secara fisik dan pengukuran beban secara mental. Pada PT XYZ para pelaksana mesin sering sekali mengeluh tentang kelelahan karena harus mengoperasikan mesin yang banyak dalam sekali kerja. Untuk mengurangi kelelahan tersebut maka dibuatlah rencana penambahan jumlah karyawan tetap untuk mengurangi beban kerja setiap pelaksana mesin.. Pengukuran beban kerja menggunakan m...

  14. Pengetahuan Individu dan Pengembangan Kerja Tim Berpengaruh Terhadap Kinerja Perusahaan di Kawasan Industri MM2100 Cikarang, Bekasi

    Directory of Open Access Journals (Sweden)

    Harapan Tarigan

    2012-01-01

    Full Text Available Individual knowledge is capital of the foundation of each individual to be able to give the best contribution to the company. The capacity and the individual expertise can be necessarily distributed to the other individuals in the company to be able to maximize values for the company. Individual knowledge that is always distributed will form the capability of team and has the high similarity so as between the individual is easy to carry out work communication but also has an impact on work flexibility of the individual and finally can give an increase in the achievement of the company. According to a survey which was conducted by means of interviews and questionnaires to 93 manufacturing industry practitioners in this research and 90 data can be used in the analysis with response rate 97 %. Datawere analyzed with PLS (Partial Least Square. It is found that individual knowledge can influence and increase team work development. The effectiveness of the work of the employee in the process of work flexibility and does not have a direct impact on increasing the process of cooperation and communication. The development of the team work to the company MM2100 cannot increase cooperation and work communication and cannot increase the effectiveness of the team work, whereas work flexibility has an impact on cooperation and communication in working place and both of them are able to increase the company’s performance.

  15. The moonlighting function of pyruvate carboxylase resides in the non-catalytic end of the TIM barrel.

    NARCIS (Netherlands)

    Huberts, D.H.; Venselaar, H.; Vriend, G.; Veenhuis, M.; Klei, I.J. van der

    2010-01-01

    Pyruvate carboxylase is a highly conserved enzyme that functions in replenishing the tricarboxylic acid cycle with oxaloacetate. In the yeast Hansenulapolymorpha, the pyruvate carboxylase protein is also required for import and assembly of the peroxisomal enzyme alcohol oxidase. This additional

  16. The moonlighting function of pyruvate carboxylase resides in the non-catalytic end of the TIM barrel

    NARCIS (Netherlands)

    Huberts, Daphne H. E. W.; Venselaar, Hanka; Vriend, Gert; Veenhuis, Marten; van der Klei, Ida J.

    Pyruvate carboxylase is a highly conserved enzyme that functions in replenishing the tricarboxylic acid cycle with oxaloacetate. In the yeast Hansenula polymorpha, the pyruvate carboxylase protein is also required for import and assembly of the peroxisomal enzyme alcohol oxidase. This additional

  17. Post-"Psychological Contract" Violation: The Durability and Transferability of Employee Perceptions. The Case of TimTec.

    Science.gov (United States)

    Pate, Judy; Malone, Charles

    2000-01-01

    Interviews with 20 employees 5 years after a factory closure explored pre- and postlayoff experiences and perceptions of current employers. The experience of the violation of the psychological contract affected perceptions of loyalty, commitment, and trust that were transferred to the current employer. (SK)

  18. Work in progress Tim Radford on research that aims to find a tiny error in Einstein's theory of special relativity

    CERN Multimedia

    Radford, T

    2004-01-01

    "Ben Varcoe wants to find a relatively small mistake in Einstein's theory of special relativity. To do this, he will slow light down from 300,000 km per second to 10 metres per second - about the speed of Darren Campbell - and see how it behaves" (1 page)

  19. T.I.M.S: TaqMan Information Management System, tools to organize data flow in a genotyping laboratory

    Directory of Open Access Journals (Sweden)

    Albion Tim

    2005-10-01

    Full Text Available Abstract Background Single Nucleotide Polymorphism (SNP genotyping is a major activity in biomedical research. The Taqman technology is one of the most commonly used approaches. It produces large amounts of data that are difficult to process by hand. Laboratories not equipped with a Laboratory Information Management System (LIMS need tools to organize the data flow. Results We propose a package of Visual Basic programs focused on sample management and on the parsing of input and output TaqMan files. The code is written in Visual Basic, embedded in the Microsoft Office package, and it allows anyone to have access to those tools, without any programming skills and with basic computer requirements. Conclusion We have created useful tools focused on management of TaqMan genotyping data, a critical issue in genotyping laboratories whithout a more sophisticated and expensive system, such as a LIMS.

  20. Evaluation of the relative risk to birds of alternative pesticides using EPA’s TIM/MCnest Model

    Science.gov (United States)

    Agricultural producers today have many choices of active ingredients for crop protection. These products come with different active ingredients, different modes of action, and that initiate different adverse outcome pathways. Use patterns also differ considerably among products...

  1. T.I.M.S: TaqMan Information Management System, tools to organize data flow in a genotyping laboratory

    Science.gov (United States)

    Monnier, Stéphanie; Cox, David G; Albion, Tim; Canzian, Federico

    2005-01-01

    Background Single Nucleotide Polymorphism (SNP) genotyping is a major activity in biomedical research. The Taqman technology is one of the most commonly used approaches. It produces large amounts of data that are difficult to process by hand. Laboratories not equipped with a Laboratory Information Management System (LIMS) need tools to organize the data flow. Results We propose a package of Visual Basic programs focused on sample management and on the parsing of input and output TaqMan files. The code is written in Visual Basic, embedded in the Microsoft Office package, and it allows anyone to have access to those tools, without any programming skills and with basic computer requirements. Conclusion We have created useful tools focused on management of TaqMan genotyping data, a critical issue in genotyping laboratories whithout a more sophisticated and expensive system, such as a LIMS. PMID:16221298

  2. Hurricane season: Systems of instability in Central and Eastern European party politics / Tim Haughton, Kevin Deegan-Krause

    Index Scriptorium Estoniae

    Haughton, Tim

    2015-01-01

    Artiklis käsitletakse Kesk- ja Ida-Euroopas (sh. Eesti) aset leidnud kiireid poliitilisi arenguid, millega on kaasas käinud muutused parteisüsteemides. Pakutakse välja uus kontseptuaalne mudel, mis aitab neid muutusi seletada.

  3. Simultaneous determination of uranium and plutonium in dissolver solution of irradiated fuel, using ID-TIMS. IRP-11

    International Nuclear Information System (INIS)

    Shah, Raju; Sasi Bhushan, K.; Govindan, R.; Alamelu, D.; Khodade, P.S.; Aggarwal, S.K.

    2007-01-01

    A simple sample preparation and simultaneous analysis method to determine uranium and plutonium from dissolver solution, employing the technique of Isotope Dilution Mass spectrometry has been demonstrated. The method used, co-elusion of Uranium and Plutonium from anion exchanger column after initial elution of major part of uranium in 1:5 HNO 3 in order to reduce the initial U/Pu ratio from 1000 to about 100-200 in the co-eluted fraction. Due to the availability of variable multi-collector system, different Faraday cups were adjusted to collect the different ion intensities corresponding to the different masses, during the simultaneous analysis of Uranium and Plutonium, loaded on Re double filament assembly. 233 U and PR grade Plutonium were used as spikes to determine Uranium and Plutonium from dissolver solution of irradiated fuel from research reactor. The possibility of getting the isotopic composition of uranium from the simultaneous analysis of co-eluted purified fraction of U and Pu from spiked aliquots is also explained. (author)

  4. Yeast Interacting Proteins Database: YHR114W, YDL217C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available y (0) YDL217C TIM22 Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopi...rey gene name TIM22 Prey description Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic

  5. IPTEKS BAGI MASYARAKAT USAHA JASA TAILOR DI KOTA SEMARANG

    Directory of Open Access Journals (Sweden)

    Sri Endah Wahyuningsih

    2016-03-01

    Full Text Available Tujuan kegiatan Ipteks bagi Masyarakat (IbM ini adalah untuk menyelesaikan permasalahan yang dihadapi oleh industri kecil jasa penjahitan busana pria dan wanita di Kecamatan Gajah Mungkur, Kota Semarang. Ada dua usaha jasa tailor yang diprioritaskan menjadi mitra IbM, yaitu Bapak Mamiek Slamet dan Ibu Sri Astuti Yudhaningrum dengan dua aspek permasalahan yang akan ditangani, yaitu aspek produksi dan aspek manajemen. Target khusus yang ingin dicapai adalah, dalam aspek produksi : 1 Dihasilkan 2 sofware pemrograman data pelanggan purnama dan dara tailor mengenai : identitas pelanggan, jenis dan ukuran pelanggan untuk model kebaya, kemeja, jas, celana dan rok, serta ongkos jahit 2 pelatihan Penggunaan mesin high speed untu produksi celana, kemeja maupun blazer 3 Menambah peralatan produksi, antara mesin jahit industri 4 Tempat material dan produk lebih tertata sehingga lebih nyaman, aman bersih, dan rapi. Dalam aspek manajemen: 1 Pembukuan data identitas, ukuran dan model baju pesanan tersimpan dalam komputer sehingga lebih cepat mencari dan mempercepat layanan lebih baik , pencatatan ongkos jahit dan keuangan lebih tertib 2 Terdapat nota sesuai identitas dan kartu nama tempat produksi. Sebagai tim pelaksana kegiatan ini melibatkan dosen dan mahasiswa dengan bidang keahlian yang sesuai dengan kebutuhan lapangan. Dalam pelaksanaan dipakai beberapa metode yang saling mendukung, antara lain dengan ceramah/ penyuluhan untuk materi yang bersifat teori dan motivasi, demonstrasi/peragaan untuk menyampaikan materi praktek/keterampilan, praktek langsung oleh mitra, dan pendampingan kegiatan. Luaran pengabdian dalam aspek produksi : 1 Dihasilkan 2 sofware pemrograman data pelanggan purnama dan dara tailor mengenai : identitas pelanggan, jenis dan ukuran pelanggan untuk model kebaya, kemeja, jas, celana dan rok, serta ongkos jahit 2 pelatihan Penggunaan mesin high speed untu produksi celana, kemeja maupun blazer 3 Menambah peralatan produksi, antara mesin

  6. Pengaruh Citra Merek (Brand Image) dan Harga terhadap Keputusan Pembelian Konsumen (Survei pada Mahasiswa Program Studi Administrasi Bisnis Fakultas Ilmu Administrasi Universitas Brawijaya Malang Tahun Angkatan 2013/2014 dan 2014/2015 Pengguna Kartu Pra-b

    OpenAIRE

    Venessa, Ike; Arifin, Zainul

    2017-01-01

    This study is aim to understand and explain : Significance of the influence of corporate image variable, consumers image variable, product image variable, price variable on consumer purchase decision all together; Significance of the influence of corporate image variable on consumer purchase decision; Significance of the influence of consumers image variable on consumer purchase decision; Significance of the influence of product image variable on consumer purchase decision; Significanc...

  7. Situs Blog Pribadi www.dianrainbow.blogspot.com dan Minat Menggunakan Jilbab (Studi Korelasional Pengaruh Situs Blog Pribadi www.dianrainbow.blogspot.com Terhadap Minat Menggunakan Jilbab Pada Mahasiswi Fakultas Keguruan Ilmu Pendidikan Universitas Muhammadyah Sumatera Utara).

    OpenAIRE

    Padang, Putri Sri Wahyuni

    2014-01-01

    The study entitled The Site of Personal Blog www.dianrainbow.blogspot.com and Interest of Using a Hijab (The Study of Correlational About Influence The Site of Personal Blog www.dianrainbow.blogspot.com Against The Interest of Using a Hijab On Coed Faculty of teacher training Education in North Sumatra Muhammadiyah University). Researchers used several theories relevant to research that is: The Uses and Gratifications Theory, Communications Technology, The Internet, Blogs and The Site of ...

  8. Pengaruh Kesadaran Merek Dan Persespsi Kualitas Terhadap Loyalitas Merek Melalui Kepercayaan Merek Sebagai Variabel Intervening Pada Ponsel Nokia ( Studi Pada Mahasiswa Fakultas Ilmu Sosial Dan Ilmu Politik Universitas Diponegoro )

    OpenAIRE

    Kurniati, Anita Dwi; Farida, Naili; Nurseto, Sendhang

    2013-01-01

    This study aims to determine the effect of brand awareness and perceived quality of the Nokia brand loyalty through brand trust as an intervening variable. The sample used by 100 respondents using Simple Random Sampling technique. The method of analysis used in this study is the Path analysis. the calculation results showed that the variables of brand awareness, perceived quality variables, and variable keperayaan each brand has a positive and significant effect on the variable of brand loyal...

  9. Eksplorasi dan Potensi Cendawan Entomopatogen Penicillium sp. Sebagai Agens Pengendali Hayati Hama Penggerek Buah Kakao, Conopomorpha cramerella (Snellen) (Nurariaty Agus, Annie P. Saranga dan Ade Rosmana; Jurusan Hama dan Penyakit Tumbuhan, Fakultas Pertanian Unhas)

    OpenAIRE

    Agus, Nurariaty

    2014-01-01

    Penggerek buah kakao (PBK), Conopomorpha cramerella (Snellen) merupakan hama utama tanaman kakao. Potensi kerugian hasil yang disebabkan oleh hama tersebut dapat mencapai 60-80 % dengan kerugian sekitar Rp 810 milyar per tahun. Salah satu musuh alami yang dapat dimanfaatkan dan berpotensi untuk dikembangkan sebagai agens pengendali hayati hama PBK adalah cendawan entomopatogen Penicillium sp. Penelitian tahun kedua ini bertujuan untuk mengetahui untuk mengetahui potensi cendawan ento...

  10. Faktor pendorong motivasi orang tua merawatkan gigi anak di klinik Fakultas Kedokteran Gigi Unair (Stimulating factor of parents' motivation to take their children's dental health for treatment in the Faculty of Dentistry Airlangga University)

    OpenAIRE

    Anggriana, Dita; Musyrifah, Musyrifah

    2006-01-01

    Children dental health is very beneficial for children's growth Parent’s motivation for taking their children dental for treatment before more serious dental damage can help to decrease the prevalence of children's dental damage, especially for patients who came to pedodontia clinic in the faculty of Dentistry Airlangga University. This study aimed to know the parents' motivation to take their children dental for treatment in Pedodontia clinic in the faculty of Dentistry Airlangga University ...

  11. Faktor pendorong motivasi orang tua merawatkan gigi anak di klinik Fakultas Kedokteran Gigi Unair (Stimulating factor of parents' motivation to take their children's dental health for treatment in the Faculty of Dentistry Airlangga University

    Directory of Open Access Journals (Sweden)

    Dita Anggriana

    2006-03-01

    Full Text Available Children dental health is very beneficial for children's growth Parent’s motivation for taking their children dental for treatment before more serious dental damage can help to decrease the prevalence of children's dental damage, especially for patients who came to pedodontia clinic in the faculty of Dentistry Airlangga University. This study aimed to know the parents' motivation to take their children dental for treatment in Pedodontia clinic in the faculty of Dentistry Airlangga University by giving questionnaire to 42 patient’s parents. The result of this study suggested that clinic’s facilities (scored: 2.86 as the stimulating factor had the biggest influence in motivating patient’s parents.

  12. Analisis Ketidakpuasan Pasca Konsumsi, Harga, Iklan, dan Kebutuhan Mencari Variasi terhadap Keputusan Perpindahan Merek Smartphone Blackberry ke Smartphone Android pada mahasiswa Program Studi Manajemen Fakultas Ekonomi Dan Bisnis Universitas Sumatera Utara

    OpenAIRE

    Kie, Juri

    2016-01-01

    This research aims to know and analyze the influence of post-consumption dissatisfaction, price, advertising, and variety seeking needs towards brand switching decisions from smartphone BlackBerry to smartphone Android to students Study Program of Management Faculty of Economics and Business University of Sumatera Utara. This research was an associative research. The population were student which ever using smartphone BlackBerry and already switch to smartphone Android and 76 of them were use...

  13. KEJADIAN OTITIS EKSTERNA PADA MASYARAKAT PENEBEL TABANAN DAN YANGAPI BANGLI YANG BERKUNJUNG KE BAKTI SOSIAL STAF MEDIS FUNGSIONAL TELINGA HIDUNG TENGGOROKAN FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA - RUMAH SAKIT UMUM PUSAT SANGLAH PADA TAHUN 2012

    Directory of Open Access Journals (Sweden)

    Putu Teguh Aryanugraha

    2016-03-01

    Full Text Available INCIDENCE RATE OF OTITIS EXTERNA IN SOCIETY OF PENEBEL AND YANGAPI BANGLI WHO VISITED THE SOCIAL ACTIVITY EAR NOSE THROAT DIVISION FACULTY OF MEDICINE UDAYANA UNIVERSITY– SANGLAH GENERAL HOSPITAL IN 2012 ABSTRACT Indonesia is a tropical country which in some places have there own temperature and humidity criteria factors predisposing to otitis externa is usually triggered by the growth of fungi that are responsible for the onset of otitis externa. The research was conducted in two places, namely in the village of Penebel Tabanan and the village of Yangapi Bangli. The aim to determine the prevalence of otitis externa, especially in people who follow social events in the village Penebel and Yangapi. This research was carried out by quantitative descriptive design with a population that is affordable and Yangapi Penebel villagers who come to charity ENT Division Sanglah Hospital. The incidence of OE in the village Penebel was 6 of 66 patients and in the village Yangapi was 3 of 96 patients. Variants OE in the village of the same Penebel lot of male patients men and women with a lifespan of 41 years and above, whereas the incidence in the village OE Yangapi more on men with an age range 21-30 years. At this research showed otitis externa patients who come to social event in both villages were 9 people from 162 patients who came to the social event ENT Division Sanglah Hospital. Keywords : Otitis externa, Gender, Age, people of Penebel and Yangapi village.

  14. PELATIHAN BERJALAN DI ATAS BALOK LURUS SEJAUH 8 METER 5 REPETISI 4 SET LEBIH BAIK DARIPADA 4 REPETISI 5 SET TERHADAP KESEIMBANGAN TUBUH MAHASISWA FAKULTAS PENDIDIKAN OLAHRAGA DAN KESEHATAN IKIP PGRI BALI

    Directory of Open Access Journals (Sweden)

    I G P Ngurah Adi Santika

    2015-01-01

    Full Text Available The Body Balance of students of the Faculty of Sport Education and Health PGRI Bali tend to decrease. This is supported by preliminary data from the body balance, that the students are in the norm level of balance. The purpose of this study was to determine the effect of walking training on a straight beam 8 m x 10 cm x 30 cm 4 sets of 5 reps increasing student body balance Faculty of Sport Education and Healt Students IKIP PGRI Bali and to investigate the training walk on a straight beam 8 m x 10 cm x 30 cm 4 sets of 5 reps improve body balance is bigger than 4 repetitions 5 sets of students of Faculty of Sport Educatoin and Healt Student IKIP PGRI Bali. This study used a pretest-posttest randomized control group design. A total of 22 students aged 18-23 years were selected as members of the sample were divided into 2 groups. Group I was given a training walk on a straight beam as far as 8 feet 5 repetitions 4 sets and a Group II are trained to walk on a straight block as far as 8 feets 4 repetitions 5 sets. Training was given 4 times a week for 6 weeks. Balancing is measured before and after training use stork balance test. T-test Paired is used to determine the balance mean difference in the balance of each group before and after treatment with a significance level of 0,05, t-independent test to determine the increasing of the body balance. The results showed an increase in of body balance of the group I and group II. The results of test paired in group I the first data is 20,02±2,52 seconds increased 40,10±3,80 seconds in group II the first data is 21,47±5,08 seconds increased 34,59±5,47 seconds by significance level of 0,05 is significantly different. Test Paired results indicate a difference of the intreasing of balance of the group I and group II. Independent test results in group I was 20,08 seconds 50,07% and in group II was 13,12 seconds 37,93%. Based on these results we can conclude that training walk on a straight block as far as 8 meters 5 repetitions 4 sets is more increase balancing walking on the straight block as far as 8 meters 4 repetitions 5 sets.

  15. Pengaruh Customer Satisfaction Terhadap Switching Barrier Dan Customer Retention (Survei Pada Mahasiswa Fakultas Ilmu Administrasi Bisnis Angkatan 2012-2013 Universitas Brawijaya Yang Pernah Melakukan Pembelian Di Mcdonald's Malang)

    OpenAIRE

    Kumalasari, Indah

    2013-01-01

    The purpose of this study is to analyze and explain the effect Customer Satisfaction of the switching barrier and Customer Retention. Type of research is explanatory research with survey methods. Sampling technique using probability sampling with simple random sampling. The population in this study is a student of the Faculty of Business Administration Forces 2012-2013 UB ever make purchases at McDonald's Malang and obtained sample was 102 respondents using Machin formula. This study uses de...

  16. Immigrants' attitudes towards welfare redistribution. An exploration of role of government preferences among immigrants and natives across 18 European welfare states / Tim Reeskens, Wim van Oorschot

    Index Scriptorium Estoniae

    Reeskens, Tim

    2015-01-01

    Artiklis käsitletakse pagulaste arvamusi heaoluriigi kohta 18 Euroopa riigis (sh Eesti), täpsemalt, kuidas nad suhtuvad saadavatesse sotsiaaltoetustesse, võrreldakse ka pagulaste hoiakuid põlisrahvastiku omadega. Aluseks 2008. aasta Euroopa sotsiaaluuringu heaolu hoiakute moodul

  17. First results from analysis of coordinated AVIRIS, TIMS, and ISM (French) data for the Ronda (Spain) and Beni Bousera (Morocco) peridotites

    Science.gov (United States)

    Mustard, J. F.; Hurtrez, S.; Pinet, P.; Sotin, C.

    1992-01-01

    Ultramafic rocks are relatively rare at the Earth's surface but constitute the vast majority of the Earth by volume. Exposures of ultramafic bodies are therefore crucial for deducing many important processes that occur in the Earth's mantle. An important science question regarding the spatial distribution, abundance, and composition of mafic minerals in ultramafic bodies that can be examined with advanced sensor data is the melting process. When a lherzolite melts, clinopyroxene (cpx) melts first and therefore variations in the modal amount of cpx remaining in the mantle are a reflection of the amount of fractional melting that has occurred. Fe goes preferentially into the melt during melting but a 20 percent batch melting (i.e. closed system) acquires less Fe relative to 20 percent fractional melting (i.e. open system). Since the strength and wavelength of diagnostic absorptions is a strong function of Fe content, it is possible to make maps of the variation in Fe:Mg ratios which can be related to the general melting process. Accurate ground-truth information about local mineralogy provides internal calibration and consistency checks. Investigations using imaging spectrometer are very complementary to field studies because advanced sensor data can provide a synoptic view of modal mineralogy and chemical composition whereas field studies focus on detailed characterization of local areas. Two excellent exposures of ultramafic lithologies are being investigated with visible to mid-infrared imaging spectrometer data: the Ronda peridotite near Ronda, Spain and the Beni Bousera ophiolitic fragment in northern Morocco. Although separated by the Alboran Sea, these bodies are thought to be related and represent fertile sub-continental mantle. The Ronda peridotite is predominantly spinel lherzolite but grades into harzburgite and shows considerable variation in major and trace element compositions. Mafic layering and dykes (i.e. olivine gabbro) are also observed. This indicates some sections of the peridotite have experienced greater degrees of partial melting. The Beni Bousera peridotite also contains mafic layers and dykes and grades into harzburgite representing similar fundamental shifts in the bulk chemistry of this ultramafic body probably related to an episode of partial melting. The specific mode of emplacement of these bodies is controversial and important for understanding the tectonic evolution of this region. Our investigations are not necessarily designed to help resolve this controversy. Rather, these exposures provide excellent and unusual examples of fertile mantle which have undergone variable degrees of partial melting.

  18. Außergerichtliche Vollstreckung aus der Hypothek und Quasi-Datio in Solutum nach russischem Recht – Teil 2 / Tim Lassen

    Index Scriptorium Estoniae

    Lassen, Tim

    2014-01-01

    Hüpoteeklaenudega seotud vaidlustest Venemaal. Hüpoteekidega seotud õigusaktide rakendamise probleemidest ja vastavatest vahekohtu lahenditest. Järg. Algus Wirtschaft und Recht in Osteuropa 20014, nr. 5, lk. 136-140

  19. Fear and Courage in Tim O'Brien's if I Die in a Combat Zone, Going After Cacciato, and the Things They Carried

    National Research Council Canada - National Science Library

    Hughes, James

    1998-01-01

    ...), deal specifically with the Vietnam war. In these works O'Brien clearly establishes fear as both a dominant aspect of the experience and an essential component necessary for the display of courage, one of his most significant considerations...

  20. Encyclopedia of Archaeology: The Great Archaeologists, Volumes I-II, edited by Tim Murray. ABC­-CLIO Inc., Santa Barbara, 1999

    OpenAIRE

    Christenson, Andrew L.

    2001-01-01

    There have been two previous volumes published on Great Archaeologists, one for young adults (Daugherty 1962) and one a collection of articles from the Illustrated London News (Bacon 1976). What really distinguishes this two volume set from the earlier books is that who was included was decided by archaeologists, rather than by educators or journalists. Archaeologists whose lives are considered great for didactic or jo...

  1. Managing Productivity and Quality in the 1990s. Some Observations on TIMS (The Institute for Management Sciences) XXIX, 23-26 July 1989, Osaka, Japan

    Science.gov (United States)

    1989-10-01

    often attempted. This profound knowledge must be possessed by management; hence Dr. Deming’s slogan: "Quality is Made in the Boardroom ." Dr. Deming...Out of the Crisis, MIT Center for Advanced Engineering Study, Cambridge, MA, 1982. 5. Lawrence M. Miller, Barbarians to Bureaucrats, Corporate Life

  2. Integrating research and practice for optimal clinical outcomes: an interview with Tim Porter-O'Grady. Interview by Gail S Wick.

    Science.gov (United States)

    Porter-O'Grady, T

    1996-06-01

    Dr. Porter-O'Grady has written over 125 articles and book chapters and has published eight books and is completing a ninth. He has consulted with over 500 institutions and has spoken in 1300 settings in the U.S., Canada, Europe, and Asia and logs about 350,000 miles a year. Dr. Porter-O'Grady is listed in six different categories of Who's Who in America, serves on 7 editorial boards, and is a member of the New York Academy of Sciences and a Fellow in the American Academy of Nursing. He has served on a number of community boards and has been an elected officer in a variety of health related agencies and organizations. He is currently a health systems expert for the National Health Policy Council and is a member of the Georgia Health Care Reform Project. In this interview, which took place in Atlanta by ANNA Past President Gail Wick, Dr. Porter-O'Grady shares his wealth of knowledge and experience by challenging us to move beyond the old thinking of caring for a specific patient population to managing lives on a continuum of care in an interdependent relationship with other providers, to refine the term "patient care," letting go of the medical sickness model and returning to our life-centered, health-oriented nursing roots and to broaden our educational preparation to a systems perspective and a continuum of caring.

  3. Analyses of TIMS and AVIRIS data, integrated with field and laboratory spectra, for lithological and mineralogical interpretation of Vulcano Island, Italy

    Science.gov (United States)

    Buongiorno, M. Fabrizia; Bogliolo, M. Paola; Salvi, Stefano; Pieri, David C.; Geneselli, Francesco

    1995-01-01

    Vulcano Island is part of the Eolian archipelago, located about 25 km from the northeast coast of Sicily. The archipelago comprises seven major volcanic islands, two of which are active volcanoes (Vulcano and Stromboli). Vulcano covers an area of about 50 square km, and is about 10 km long. Explosive volcanic activity has predominated in the geological evolution of Vulcano Island, and there is no evidence that this pattern has ceased. Rather, the current situation is one of unrest, so a strict regimen of continuous geophysical and geochemical monitoring has been undertaken over the last decade. Though the year-round population of Vulcano is small (under 1000), during the summer the island becomes a very popular resort, and has thousands of additional tourists at any time throughout the high season, thus substantially increasing the number of people potentially at risk from an explosive eruption or other hazards such as noxious gas emissions (e.g., CO2, H2S, SO2). During the past ten years, remote sensing data have been repetitively acquired with optical and microwave airborne sensors. The present work shows the preliminary results of a study based on the integration of various remote sensing data sets with field spectroscopy, and other laboratory analyses, for the geological and geomorphological mapping of the island. It is hoped that such work will also usefully contribute to the evaluation of the volcanic hazard potential of the islands as well as to the evaluation of the status of its current activity.

  4. BOOK REVIEW: ADRENALINE JUNKIES AND TEMPLATE ZOMBIES Understanding Patterns of Project Behavior by Tom Demarco, Peter Hruschka, Tim Lister, Steve McMenamin, James Robertson, Suzanne Robertson

    Directory of Open Access Journals (Sweden)

    DR. KADIR ALPASLAN DEMIR

    2016-10-01

    Full Text Available Today, armed forces are in continuous transformation. As new technologies are developed and new principles of war are introduced, the ministries of defenses and armed forces have to adapt to this changing environment. Almost every day, military officials start new projects to handle the technological and cultural transformations in the military. Project management became an integral part of defense development and management. Today, all high or middle level military officials are either a project sponsor overseeing a project, or a project manager executing a project, or a member of project team helping the project to become a reality. As a result, project management skills became an essential part of skillset that a military official need to successfully execute his/her duties.

  5. Perbedaan Sikap Pemilih Pemula Antara Peserta Dan Bukan Peserta “Roadshow Pendidikan Pemilu”

    Directory of Open Access Journals (Sweden)

    Almira Ditrya Kartikatantri

    2015-07-01

    Universitas Indonesia sebagai peserta dan mahasiswa D3 Studi Ilmu Sosial dan Politik Universitas Indonesia yang bukan sebagai peserta “Roadshow Pendidikan Pemilu” dalam Pemilihan Umum Legislatif 2014. Dalam penelitian ini digunakan metode kuantitatif, berdasarkan Teori Persuasi (Instrumental Theory of Persuassions yang dikemukakan oleh Hovland, Janis, dan Kelly. Pengujian yang digunakan adalah uji beda Mann-Whitney dengan teknik analisis deskriptif dan interferensial. Hasil penelitian menunjukkan bahwa terdapat perbedaan sikap yang signifikan antara sampel yang mengikuti dengan yang tidak mengikuti kampanye “Roadshow Pendidikan Pemilu” yang diadakan oleh tim AyoVote. Artinya kegiatan yang dilakukan berhasil mengubah sikap peserta kegiatan menjadi lebih positif sesuai dengan harapan pelaksana kegiatan. Berdasarkan hasil penelitian ini, penulis menyarankan agar tim AyoVote membenahi isi pesan supaya lebih terstruktur dan lebih menarik untuk disampaikan kepada peserta, sehingga pengaruh yang diberikan akan dapat lebih signifikan dan menambah frekuensi pelaksanaan kegiatan, sehingga makin banyak orang yang tahu berbagai ilmu dasar politik dan sadar akan kewajibannya sebagai masyarakat Indonesia yang memilki hak pilih untuk menentukan masa depan negerinya.

  6. Reviewer Volume 27, Tahun 2007

    OpenAIRE

    Volume 27, Tahun 2007, Reviewer

    2007-01-01

    1. Abdul Rozaq, Dr., Ir., DAA Jurusan Teknik Pertanian (TEP), Fakultas Teknologi Pertanian (FTP), Universitas Gadjah Mada (UGM), Yogyakarta2. Bambang Purwantana, Ir., Dr., M.Agr. Jurusan TEP, FTP-UGM3. Chusnul Hidayat, Ir., Dr. Jurusan Teknologi Pangan dan Hasil Pertanian (TPHP), Fakultas Teknologi Pertanian (FTP), Universitas Gadjah Mada (UGM), Yogyakarta4. Haryadi, Ir., Dr., Prof., M. App. Sc. Jurusan TPHP, FTP-UGM5. Lilik Sutiarso, Ir., Dr., M. Eng. Jurusan TEP, FTP-UGM6. Pudji Hastuti, Ir...

  7. Penyajian Data Komoditi Batik Kabupaten Sukoharjo Dengan Google Earth

    OpenAIRE

    Ukhti Ikhsani Larasati; Much Aziz Muslim

    2016-01-01

    Kabupaten Sukoharjo memiliki banyak potensi daerah yang merupakan komoditi unggulan kabupaten yaitu komoditi mebel kayu, mebel rotan, batik, tekstil dan produk tekstil, kaca grafir, kerajinan kulit/tatah sungging (wayang), kerajinan gitar, kerajinan gamelan, shuttlecock, jamu tradisional, emping mlinjo, sarung goyor, beras, dan alkohol. Dinas Perindustrian dan Perdagangan kabupaten Sukoharjo adalah salah satu pelaksana urusan Pemerintah Daerah kabupaten Sukoharjo di bidang perindustrian dan p...

  8. IMPLEMENTASI PROGRAM ALOKASI DANA DESA (ADD DALAM PEMBERDAYAAN MASYARAKAT DI DESA PUNAGAYA KECAMATAN BANGKALA KABUPATEN JENEPONTO

    Directory of Open Access Journals (Sweden)

    Octrian TSL

    2013-04-01

    expected to increase creativity, prosperity and jobs for the community. Desa Punagaya melalui Alokasi dana desa (ADD akan mengalokasikan anggaran untuk pemberdayaan masyarakat di bidang usaha produksi gula merah,penelitian ini bertujuan untuk melihat implementasi alokasi dana dalam program pemberdayaan masyarakat desa dan faktor yang mempengaruhi pelaksanaan implementasi alokasi dana desa dalam program pemberdayaan masyarakat di Desa Punagaya kecamatan Bangkala kabupaten Jeneponto. Penelitian ini merupakan jenis penelitian deskriptif kualitatif dengan teknik penarikan sampel yang digunakan adalah purposive sampling. Penelitian ini menggunakan teknik analisis data hasil wawancara dan observasi , dimana setelah data dikumpulkan selanjutnya dianalisis dengan menggunakan tabel frekwensi kemudian di deskripsikan secara kualitatif. Jumlah sampel 33 orang terdiri dari Kepala desa 1 orang, Sekretaris desa 1 orang, anggota Panitia seminar 5 orang , Masyarakat setempat 7 orang, Ibu PKK 4 orang , Pembuat gula merah 6 orang, Tim Pelaksana Bantuan Langsung ADD 3orang, Tokoh masyarakat 6 orang. Penelitaian ini menunjukkan bahwa sebesar 52% masyarakat Desa punagaya beranggapan bahwa implementasi alokasi dana desa di Desa punagaya kurang baik hal ini terjadi karena masyarakat tidak melihat adanya program yang dilakukan oleh pemerintah setempat guna meningkatkan pemberdayaan masyarakat dan peningkatan perbaikan pelayanan yang dilakukan oleh pemerintah setempat dengan menggunakan alokasi dana desa. Berdasarkan penelitian yang telah penulis lakukan, dapat disimpulkan bahwa masyarakat belum diberdayakan secara optimal dalam pemanfaatan DD di Desa Punagaya Kecamatan Bangkala Kabupaten Jeneponto. Hal ini disebabkan karena adanya masalah seperti alokasi dana yang diberikan belum memadai untuk meningatkan pemberdayaan masyarakat , selain itu alokasi dana ini sering terlambat diberikan dan rendahmya pengaruh aparatur desa terhadap pengembangan dan pengelolaan alokasi dana desa ini menjadi faktor

  9. PERBAIKAN PENGELOLAAN UMKM GUNA PENGEMBANGAN USAHA MIKRO

    Directory of Open Access Journals (Sweden)

    Rosita Rosita

    2017-03-01

    Full Text Available ABSTRAK Program pengabdian ini dilakukan pada UMKM yang bergerak daam bidang usaha manufaktur (mitra 1 yaitu Nufarozan Bedding Goods dan UMKM bergerak dalam bidang dagang (mitra 2 yaitu SB Alat Kebersihan. Mitra 1 yang memiliki permsaalahan manajemen usaha yang belum profesional dan belum menghasilkan pendapatan usaha yang optimal sehingga kesulitan untuk bisa mengembangkan usahanya. Demikian pula dengan mitra 2 memiliki permasalahan yang hampir sama yaitu pengelolaan yang masih menjadi satu dengan pengelolaan rumah tangga sehingga belum bisa optimal dalam usahanya. Penataan dan sarana untuk memperoleh pendapatan dari penjualan kurang diperhatikan, sehingga pendapatan usaha hanya cukup untuk bertahan hidup saja. Pelaksanaan kegiatan pengabdian dilakukan di kedua UMKM mitra dengan memberikan pendampingan manajemen dan pengelolaan keuangan. Kegiatan pendampingan dimulai dari perbaikan pengelolaan keuangan dari kedua mitra. Penghitungan biaya produksi diberikan konsep untuk mitra Nufarozan, demikian juga dengan pengelolaan kas usaha melalui pencatatan arus kas. Kemudian ada perbaikan ruang usaha berupa layout usaha yang lebih efektif dan efisien. Pada mitra SB Alat Kebersihan juga dilakukan perbaikan pendampingan pengelolaan keuangan dari pengelolaan persediaan barang dagangan dan pencatatan arus kas. Untuk pengelolaan manajemen ada perbaikan layout ruang display barang dagangan. Kegiatan pengabdian dengan telah menghasilkan manajemen produksi dan manajemen usaha secara keseluruhan yang lebih baik bagi mitra 1 dan mitra 2. Ruang usaha telah terbentuk untuk mitra 1 dan mitra 2. Pemasaran online juga telah dilakukan melalui blog yang telah dibuatkan oleh tim pelaksana. Kata kunci : UMKM, manajemen profesional, pemasaran, keuangan, pendapatan, layout, pemasaran online, ruang usaha ABSTRACT This study proposed to SMEs and it will be conducted on Nufarozan Bedding Goods as the first partnership of manufacture business and SB Alat Kebersihan as the

  10. PENGEMBANGAN APLIKASI MANAJEMEN PROYEK SECARA GRAFIS BERBASIS WEB MENGGUNAKAN METODE DIAGRAM PRESEDENSI

    Directory of Open Access Journals (Sweden)

    Suhadi Lili

    2004-07-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Dalam kegiatan manajemen proyek diperlukan koordinasi yang bagus dan kerjasama tim yang kompak antar divisi pelaksana proyek. Selama ini, secara kovensional untuk membuat perencanaan proyek maupun melakukan review dan evaluasi jalannya proyek, perlu diadakan rapat atau pertemuan langsung dari orang-orang yang berperan sebagai manajer dan perencana. Para manajer profesional ini seringkali adalah orang-orang yang mobilitasnya tinggi sehingga tidak selalu berada ditempat pada saat dibutuhkan, sehingga koordinasi proyek akan terhambat dan menjadi tidak efisien. Dengan adanya kemajuan teknologi pada saat ini khususnya internet, permasalahan tersebut sangat memungkinkan untuk diselesaikan dengan menyediakan perangkat lunak yang dikhususkan untuk manajemen proyek, yang bisa diakses online secara multiuser dengan pendekatan sifat real time sehingga para manajer dapat melakukan kolaborasi kerja di mana saja mereka berada selama tersedia perangkat komputer yang terhubung dengan internet. Penelitian ini bertujuan untuk membuat perangkat lunak tersebut. Dalam Teknik Informatika, aplikasi seperti ini merupakan aplikasi terdistribusi, karena itu idealnya harus dibuat bersifat portabel agar dapat berjalan pada semua sistim

  11. Substrate-Induced Dimerization of Engineered Monomeric Variants of Triosephosphate Isomerase from Trichomonas vaginalis.

    Directory of Open Access Journals (Sweden)

    Samuel Lara-Gonzalez

    Full Text Available The dimeric nature of triosephosphate isomerases (TIMs is maintained by an extensive surface area interface of more than 1600 Å2. TIMs from Trichomonas vaginalis (TvTIM are held in their dimeric state by two mechanisms: a ball and socket interaction of residue 45 of one subunit that fits into the hydrophobic pocket of the complementary subunit and by swapping of loop 3 between subunits. TvTIMs differ from other TIMs in their unfolding energetics. In TvTIMs the energy necessary to unfold a monomer is greater than the energy necessary to dissociate the dimer. Herein we found that the character of residue I45 controls the dimer-monomer equilibrium in TvTIMs. Unfolding experiments employing monomeric and dimeric mutants led us to conclude that dimeric TvTIMs unfold following a four state model denaturation process whereas monomeric TvTIMs follow a three state model. In contrast to other monomeric TIMs, monomeric variants of TvTIM1 are stable and unexpectedly one of them (I45A is only 29-fold less active than wild-type TvTIM1. The high enzymatic activity of monomeric TvTIMs contrast with the marginal catalytic activity of diverse monomeric TIMs variants. The stability of the monomeric variants of TvTIM1 and the use of cross-linking and analytical ultracentrifugation experiments permit us to understand the differences between the catalytic activities of TvTIMs and other marginally active monomeric TIMs. As TvTIMs do not unfold upon dimer dissociation, herein we found that the high enzymatic activity of monomeric TvTIM variants is explained by the formation of catalytic dimeric competent species assisted by substrate binding.

  12. USULAN PERBAIKAN KUALITAS PELAYANAN ADMINISTRASI MAHASISWA MENGGUNAKAN METODE QUALITY FUNCTION DEPLOYMENT (QFD

    Directory of Open Access Journals (Sweden)

    Vera Devani

    2012-12-01

    Full Text Available Agar pelayanan yang dilakukan di bagian administrasi mahasiswa Fakultas Sains dan Teknologi UIN SUSKA Riau dapat memenuhi keinginan mahasiswa maka dilakukan perbaikan kualitas yang menitikberatkan pada pemenuhan keinginan mahasiswa. Perbaikan kualitas menggunakan metode Quality Function Deployment dapat menerjemahkan keinginan mahasiswa ke dalam tindkan perbaikan kualitas dari bagian administrasi fakultas. Dari hasil penelitian diperoleh beberapa tindakan sebagai usulan perbaikan kualitas pelayanan yaitu membuat SOP pengurusan administrasi dan mensosialisasikannya, menentukan waktu tiap bentuk pengurusan administrasi, melakukan perencanaan kebutuhan administrasi mahasiswa dan perpustakaan sesuai dengan perkembangan teknologi, pegawai administrasi sebaiknya menguasai keahlian administrasi, pegawai administrasi memperlihatkan sikap dan kepribadian yang baik, dan dilakukan pengontrolan terhadap pelayanan administrasi.

  13. The effect of the TIM program (Transfer ICU Medication reconciliation) on medication transfer errors in two Dutch intensive care units : Design of a prospective 8-month observational study with a before and after period

    NARCIS (Netherlands)

    B.E. Bosma (Bertha); E. Meuwese (Edmé); S.S. Tan (Siok Swan); J. van Bommel (Jasper); Melief, P.H.G.J. (Piet Herman Gerard Jan); N.G.M. Hunfeld (Nicola); P.M.L.A. van den Bemt (Patricia)

    2017-01-01

    markdownabstract__Background:__ The transfer of patients to and from the Intensive Care Unit (ICU) is prone to medication errors. The aim of the present study is to determine whether the number of medication errors at ICU admission and discharge and the associated potential harm and costs are

  14. Monazite ID-TIMS U-Pb geochronology in the LAGIR laboratory, Rio de Janeiro State University: protocols and first applications to the assembly of Gondwana supercontinent in SE-Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Aguair Neto, Carla Cristiane; Valeriano, Claudio M.; Heilbron, Monica; Lobato, Marcela, E-mail: neto.carla@hotmail.com [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil). Faculdade de Geologia. Lab. de Geocronologia e Isotopos Radiogenicos; Passarelli, Claudia R. [Universidade de Sao Paulo (USP), SP (Brazil). Instituto de Geociencias

    2014-03-15

    The chemical and spectrometric procedures of the U-Pb geochronology method on monazites, recently installed in the LAGIR laboratory, are described in detail. In addition, preliminary results on monazite samples from the Brasilia and Ribeira belts are reported and discussed in the context of the regional geology. Several experiments for calibration of ion exchange chromatographic columns with the AG-1x8 resin, were performed with HCl, using dissolved natural monazite samples. The Pb blanks of reagents are ∼ 0.5 pg/g in acids and ∼1 pg/g in H{sub 2}O. The total Pb blanks in chemical procedures were below 22 pg. Preliminary results are presented from three case studies related to Brasiliano orogenic belts of SE-Brazil, which correlate very well with previous age determinations from literature: two sub-concordant grains from an Araxa Group quartzite (southern Brasilia belt) define a concordia age of 602.6 ±1.4 Ma; a -0.8% discordant grain from a quartzite of the Sao Fidelis Group (Costeiro Domain, central Ribeira belt) yielded a concordia age of 535.3 ± 2.4 Ma; two 0.4 % and 1.3 % discordant monazite grains from the post-collisional Itaoca Granite (Costeiro Domain, central Ribeira belt) define a concordia age of 476.4 ± 1.8 Ma. (author)

  15. Analisa Beban Kerja Fisik dan Mental dengan Menggunakan Work Sampling dan NASA-TLX Untuk Menentukan Jumlah Operator

    Directory of Open Access Journals (Sweden)

    Anton Maretno

    2015-04-01

    Full Text Available Perbedaan sistem kerja yang ada di antara operator Quality Control dan operator produksi pada divisi Particle Board menyebabkan adanya perbedaan nilai beban kerja. Hal tersebut dapat dilihat dari perbedaan jumlah jam lembur pada kedua bagian tersebut dimana jumlah jam lembur pada operator Quality Control lebih besar. Penelitian ini bertujuan untuk menganalisa beban kerja operator Quality Control serta menganalisa jumlah operator yang optimal untuk menyelesaikan pekerjaan Quality Control.Penelitian ini menggunakan metode pengukuran beban kerja fisik (Work sampling dan pengukuran beban kerja Mental NASA - Task Load Index (NASA-TLX. Menurut perhitungan beban kerja fisik dan mental, pelaksana yang memiliki load paling tinggi adalah pekerjaanQuality Control ( QC Finish board (108.1%, sedangkan terendah ada pada pekerjaan Quality Control ( QC Produk (72.3%. Setelah penambahan pelaksana  Quality Control ( QC Finish board sebanyak 1 orang, beban kerja fisik untuk pekerjaanQuality Control ( QC Finish board menjadi 71.1%. Sedangkan untuk pekerjaan Quality Control yang lain tidak membutuhkan tambahan operator karena bisa memanfaatkan waktu idle yang dimiliki pelaksana Quality Control ( QC Produk untuk membantu pekerjaan lain

  16. Making the connection: advancing traffic incident management in transportation planning : a primer.

    Science.gov (United States)

    2013-07-01

    "The intent of this primer is to inform and guide traffic incident management (TIM) professionals and transportation planners to initiate and develop collaborative relationships and advance TIM programs through the metropolitan planning process. The ...

  17. Wyoming CV Pilot Traveler Information Message Sample

    Data.gov (United States)

    Department of Transportation — This dataset contains a sample of the sanitized Traveler Information Messages (TIM) being generated by the Wyoming Connected Vehicle (CV) Pilot. The full set of TIMs...

  18. 77 FR 27817 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Approving a Proposed Rule Change To List...

    Science.gov (United States)

    2012-05-11

    ... its parent company or its affiliates. See id. \\9\\ See email from Tim Malinowski, Senior Director, NYSE... IIV is no longer calculated or available as required. \\17\\ See email from Tim Malinowski, Senior...

  19. Perbandingan Gratification Sought Dan Gratification Obtained Pendengar Terhadap Program Stasiun Radio (Studi Komparatif tentang Motif dan Kepuasan Pendengar terhadap Program Stasiun Radio Kiss FM dan Prambors Medan di Kalangan Mahasiswa FISIP USU

    OpenAIRE

    Hutapea, Darma Lestari

    2011-01-01

    Penelitian ini bertujuan untuk membandingkan kepuasan ynag dicari (gratification sought) dan kepuasan yang diperoleh (gratification obtained) pendengar radio Kiss FM dan Prambors FM Medan dengan menggunakan perspektif Uses and Gratification. Model ini menekankan bahwa khalayak adalah pihak yang aktif terhadap penggunaan media. Khalayak bebas mengkonsumsi media yang disukainya. Sampel dalam penelitian ini adalah mahasiswa Fakultas Ilmu Sosial dan Ilmu Politik. Jumlah sampel y...

  20. Growth of Czech Breastfed Infants in Comparison with the World Health Organization Standards

    Czech Academy of Sciences Publication Activity Database

    Vignerová, J.; Shriver, L.; Paulová, M.; Brabec, Marek; Schneidrová, D.; Růžková, R.; Procházka, B.; Riedlová, J.

    2015-01-01

    Roč. 23, č. 1 (2015), s. 32-38 ISSN 1210-7778 Grant - others:GA MZd(CZ) NS9974; Pedagogická fakulta UK(CZ) PRVOUK P02 Institutional support: RVO:67985807 Keywords : breastfeeding * Czech * growth standards * infants * national references * WHO standards Subject RIV: FG - Pediatrics Impact factor: 0.525, year: 2015