IDENTIFIKASI TINGKAT KUALITAS PELAYANAN JASA PENDIDIKAN DENGANMENGGUNAKAN SERVQUALDI FAKULTAS TEKNIK UNIVERSITAS X

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Chalis Fajri Hasibuan

2017-04-01

Full Text Available Persaingan di dalam dunia pendidikan dewasa ini semakin ketat, khususnya perguruan tinggi, bukan hanya perguruan tinggi dalam negeri saja yang menjadi pesaing tetapi juga perguruan tinggi luar negeri.Minat masyarakat Indonesia semakin tinggi terhadap perguruan tinggi luar negeri yang menawarkan kualitas jasa pendidikan yang lebih baik. Adapun tujuan dalam penelitian ini yaitu Mengukur tingkat kepuasan mahasiswa/i Fakultas Teknik Universitas X terhadap pelayanan jasa yang diberikan oleh Fakultas Teknik Universitas X. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan teknik survey.Metode yang digunakan adalah metode Servqual.Metode servqual digunakan untuk menentukan atribut serta mengukur kesenjangan (gap antara harapan dengan persepsi konsumen terhadap suatu pelayanan. Hasil penelitian diperoleh gap Dengan nilai terbesar yakni -0.9186 menunjukkan bahwa fasilitas yang diberikan belum sesuai dengan biaya uang kuliah yang dibayarkan oleh mahasiswa sedangkan Tingkat pendidikan Dosen yang mengajar di UMA sudah berpendidikan minimal S2 dengan gap yang bernilai positif sebesar 0.0679 yang mengindekasikan bahwa tingkat harapan yang ada pada mahasiswa lebih rendah dari kinerja yang diberikan oleh Universitas X.

Aktor Pelaksana Pengelolaan Transportasi Publik Perkotaan (Studi Kasus Bus Trans Metro Di Kota Pekanbaru

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Raden Imam Al Hafis

2014-04-01

Full Text Available Modernisasi dalam bidang transportasi merupakan suatu terobosan bagi pemerintah untuk memperbaiki sistem pelayanan dalam bidang angkutan umum. Pertumbuhan ekonomi suatu negara atau bangsa tergantung tersedianya pengangkutan dalam negara atau bangsa yang bersangkutan. Agar hal tersebut bisa terwujud, maka dalam pengelolaannya diperlukan aktor lain diluar pemerintah agar pelaksanaan kebijakan dapat disinergikan sehingga dapat memperoleh hasil yang maksimal dalam pencapaian tujuan dari kebijakan. Penelitian yang digunakan adalah penelitian deskriptif kualitatif, yakni jenis penelitian yang menggambarkan suatu fenomena atau kejadian secara apa adanya. Hasil yang diperoleh dalam penelitian ini bahwa aktor utama dalam kegiatan pengelolaan transportasi publik perkotaan yaitu pemerintah (Dinas Perhubungan Komunikasi dan Informatika Kota Pekanbaru. Diperlukan keterlibatan aktor diluar pemerintah dalam melakukan kegiatan pengelolaan transportasi publik perkotaan (Bus Trans Metro Pekanbaru agar hasil yang dicapai terlaksana secara optimal. Kata Kunci : Angkutan Perkotaan, Aktor pelaksana, pengelolaan transportasi publik perkotaan.

Tim Berners-Lee during the WSIS

CERN Multimedia

Maximilien Brice

2003-01-01

Tim Berners-Lee stands in front of the first web server at the Geneva Palexpo during the World Summit on the Information Society (WSIS) in 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

TIM-1 signaling in B cells regulates antibody production

International Nuclear Information System (INIS)

Ma, Juan; Usui, Yoshihiko; Takeda, Kazuyoshi; Harada, Norihiro; Yagita, Hideo; Okumura, Ko; Akiba, Hisaya

2011-01-01

Highlights: → TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. → Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. → TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo. -- Abstract: Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other hand, TIM-1 ligand was constitutively expressed on B cells and inducible on anti-CD3 + anti-CD28-stimulated CD4 + T cells. In vitro stimulation of activated B cells by anti-TIM-1 mAb enhanced proliferation and expression of a plasma cell marker syndecan-1 (CD138). We further examined the effect of TIM-1 signaling on antibody production in vitro and in vivo. Higher levels of IgG2b and IgG3 secretion were detected in the culture supernatants of the anti-TIM-1-stimulated B cells as compared with the control IgG-stimulated B cells. When immunized with T-independent antigen TNP-Ficoll, TNP-specific IgG1, IgG2b, and IgG3 Abs were slightly increased in the anti-TIM-1-treated mice. When immunized with T-dependent antigen OVA, serum levels of OVA-specific IgG2b, IgG3, and IgE Abs were significantly increased in the anti-TIM-1-treated mice as compared with the control IgG-treated mice. These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation.

TIM-1 signaling in B cells regulates antibody production

Energy Technology Data Exchange (ETDEWEB)

Ma, Juan [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Usui, Yoshihiko [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku-ku, Tokyo 160-0023 (Japan); Takeda, Kazuyoshi [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Harada, Norihiro [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Department of Respiratory Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Research Institute for Diseases of Old Ages, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Yagita, Hideo; Okumura, Ko [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Akiba, Hisaya, E-mail: hisaya@juntendo.ac.jp [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)

2011-03-11

Highlights: {yields} TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. {yields} Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. {yields} TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo. -- Abstract: Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other hand, TIM-1 ligand was constitutively expressed on B cells and inducible on anti-CD3{sup +} anti-CD28-stimulated CD4{sup +} T cells. In vitro stimulation of activated B cells by anti-TIM-1 mAb enhanced proliferation and expression of a plasma cell marker syndecan-1 (CD138). We further examined the effect of TIM-1 signaling on antibody production in vitro and in vivo. Higher levels of IgG2b and IgG3 secretion were detected in the culture supernatants of the anti-TIM-1-stimulated B cells as compared with the control IgG-stimulated B cells. When immunized with T-independent antigen TNP-Ficoll, TNP-specific IgG1, IgG2b, and IgG3 Abs were slightly increased in the anti-TIM-1-treated mice. When immunized with T-dependent antigen OVA, serum levels of OVA-specific IgG2b, IgG3, and IgE Abs were significantly increased in the anti-TIM-1-treated mice as compared with the control IgG-treated mice. These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation.

HUBUNGAN ANTARA MENONTON IKLAN WECHAT DI TELEVISI DAN MINAT PENGGUNA SMARTPHONE DALAM MENGGUNAKAN APLIKASI WECHAT PADA MAHASISWA FAKULTAS ILMU SOSIAL DAN ILMU POLITIK UNIVERSITAS HASANUDDIN

OpenAIRE

ANIS, ANDI MOHAMMAD MENTARIFAJAR

2013-01-01

2013 ANDI MOHAMMAD MENTARIFAJAR ANIS. Hubungan Antara Menonton Iklan WeChat di Televisi dan Minat Pengguna Smartphone dalam Menggunakan Aplikasi WeChat pada Mahasiswa Fakultas Ilmu Sosial dan Ilmu Politik Universitas Hasanuddin (Dibimbing oleh Kahar dan Andi Subhan Amir). Penelitian ini bertujuan untuk mengetahui minat menonton iklan WeChat mahasiswa Fakultas Ilmu Sosial dan Ilmu Politik Universitas Hasanuddin dan juga minat pengguna smartphone ter...

Characterizing Functional Domains for TIM-Mediated Enveloped Virus Entry

Science.gov (United States)

Moller-Tank, Sven; Albritton, Lorraine M.; Rennert, Paul D.

2014-01-01

ABSTRACT T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance entry of Ebola virus (EBOV) and other viruses by binding PtdSer on the viral envelope, concentrating virus on the cell surface, and promoting subsequent internalization. The PtdSer-binding activity of the immunoglobulin-like variable (IgV) domain is essential for both virus binding and internalization by TIM-1. However, TIM-3, whose IgV domain also binds PtdSer, does not effectively enhance virus entry, indicating that other domains of TIM proteins are functionally important. Here, we investigate the domains supporting enhancement of enveloped virus entry, thereby defining the features necessary for a functional PVEER. Using a variety of chimeras and deletion mutants, we found that in addition to a functional PtdSer-binding domain PVEERs require a stalk domain of sufficient length, containing sequences that promote an extended structure. Neither the cytoplasmic nor the transmembrane domain of TIM-1 is essential for enhancing virus entry, provided the protein is still plasma membrane bound. Based on these defined characteristics, we generated a mimic lacking TIM sequences and composed of annexin V, the mucin-like domain of α-dystroglycan, and a glycophosphatidylinositol anchor that functioned as a PVEER to enhance transduction of virions displaying Ebola, Chikungunya, Ross River, or Sindbis virus glycoproteins. This identification of the key features necessary for PtdSer-mediated enhancement of virus entry provides a basis for more effective recognition of unknown PVEERs. IMPORTANCE T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members are recently identified phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance virus entry by binding the phospholipid, PtdSer, present on the viral

Tim Berners-Lee receives the Millennium Technology Prize

CERN Multimedia

2004-01-01

On 15 April, for his invention of the Web, Tim Berners-Lee was awarded the first ever Millennium Technology Prize by the Finnish Technology Award Foundation, which recognises technological innovations of lasting benefit to society. "Tim Berners-Lee's invention perfectly encapsulates the spirit of the Prize. The Web is encouraging new types of social networks, contributing to transparency and democracy, and opening up new avenues for information management and business development," underlined Pekka Tarjanne, chairman of the jury and former Secretary-General of the International Telecommunication Union (ITU). Tim Berners-Lee is congratulated by Jukka Valtasaari, Finland's Ambassador to the United States. Tim Berners-Lee created the first server, browser and editor, the HTML code, the URL address and the HTTP transmission protocol at CERN in 1990. CERN released the Web into the public domain in 1993. Tim Berners-Lee is currently head of the World Wide Web Consortium, managed by ERCIM (Europe...

Evaluasi Soft Skills dalam Pembelajaran Mahasiswa Baru di Fakultas Teknologi Pertanian Universitas Udayana

OpenAIRE

Arnata, I Wayan; Surjoseputro, Sutarjo

2014-01-01

: Penelitian ini dilakukan dengan tujuan untuk mengevaluasi atribut soft skills yang dimiliki oleh mahasiswa baru Fakultas Teknologi Pertanian Universitas Udayana. Penelitian dilakukan dengan menggunakan desain pretest-posttest menggunakan kuesioner yang berisi atribut-atribut soft skills dan penilaian kemampuan pribadi. Dari hasil evaluasi terhadap pengembangan atribut soft skills diperoleh bahwa kemampuan soft skills yang dimiliki oleh mahasiswa baru setelah mengikuti pelatihan semuanya men...

Perbedaan Penggunaan Standar Baru Antropometri WHO-2006 terhadap Peningkatan Pengetahuan dan Penilaian Status Gizi pada Tenaga Gizi Pelaksana di Kota Banda Aceh Tahun 2009

Directory of Open Access Journals (Sweden)

Alfridsyah Alfridsyah

2013-12-01

Full Text Available Latar belakang: Pada tahun 2003, WHO merumuskan konsep Multicenter Growth References Study (MGRS yang dilakukan di 6 negara dengan jumlah sampel yang diambil sebanyak 8440 anak hidup di lingkungan sehat yang memungkinkan tumbuh sesuai potensi genetik. Riset Kesehatan Dasar (Riskesdas yang dilakukan secara serentak di 33 provinsi di Indonesia pada tahun 2007 dalam penilaian status gizi balita telah mengacu pada WHO 2006. Secara keseluruhan Provinsi NAD termasuk ke dalam 10 besar yang mempunyai masalah gizi. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan standar baru antropometri 2006 terhadap peningkatan pengetahuan dan penilaian status gizi pada Tenaga GiziPelaksana (TGP di Kota Banda Aceh tahun 2009. Metode: Rancangan penelitian ini merupakan metode analitik eksploratif dengan pendekatan Quasi Experimental Design, yang dilakukan pada 70 TGP dan dibagi ke dalam dua kelompok. Data yang dikumpulkan meliputi data primer dan sekunder. Analisis data menggunakan Independent T-Test dan DependentT-Test pada CI: 95%. Hasil: Hasil analisis Independent T-Test menunjukkan bahwa terdapat perbedaan yang signifikan antara pengetahuan (p = 0,000, sikap (p = 0,004, perilaku (p = 0,005 dan peningkatan PSG (p = 0,031 antara post test pada kelompok ceramah disertai diskusi dengan ceramah disertai praktik. Sedangkan hasil analisis Dependent T-Test menunjukkan adanya peningkatan yang signifi kan dari pre tes ke post tes terhadap kedua kelompok pada TGP dalam wilayah kerja Kota Banda Aceh. Kesimpulan: Metode ceramah disertai praktik dan metode ceramah disertai diskusi dapat meningkatkan pengetahuan, sikap, perilaku dan penilaian status gizi oleh TGP, pendidikan kesehatan penilaian status gizimenggunakan standar antropometri baru WHO-2006 dengan metode ceramah disertai praktik lebih efektif dibandingkan metode ceramah disertai diskusi, dan ada pengaruh yang signifi kan penggunaan standar antropometri baru WHO-2006 terhadap peningkatan pengetahuan

Preliminary crystallographic studies of yeast mitochondrial peripheral membrane protein Tim44p

Energy Technology Data Exchange (ETDEWEB)

Josyula, Ratnakar [Department of Cell Biology, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States); Jin, Zhongmin [SER-CAT, APS, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); McCombs, Deborah; DeLucas, Lawrence [Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States); Sha, Bingdong, E-mail: bdsha@uab.edu [Department of Cell Biology, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States)

2006-02-01

Tim44p is an essential mitochondrial peripheral membrane protein. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, the yeast Tim44p has been crystallized. Protein translocations across mitochondrial membranes play critical roles in mitochondrion biogenesis. Protein transport from the cell cytosol to the mitochondrial matrix is carried out by the translocase of the outer membrane (TOM) complex and the translocase of the inner membrane (TIM) complexes. Tim44p is an essential mitochondrial peripheral membrane protein and a major component of the TIM23 translocon. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, the yeast Tim44p was crystallized. The crystals diffract to 3.2 Å using a synchrotron X-ray source and belong to space group P6{sub 3}22, with unit-cell parameters a = 124.25, c = 77.83 Å. There is one Tim44p molecule in one asymmetric unit, which corresponds to a solvent content of approximately 43%. Structure determination by MAD methods is under way.

Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry

Science.gov (United States)

Moller-Tank, Sven; Kondratowicz, Andrew S.; Davey, Robert A.; Rennert, Paul D.

2013-01-01

The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction with PtdSer on the viral envelope. PtdSer liposomes but not phosphatidylcholine liposomes competed with TIM-1 for EBOV pseudovirion binding and transduction. Further, annexin V (AnxV) substituted for the TIM-1 IgV domain, supporting a PtdSer-dependent mechanism. Our findings suggest that TIM-1-dependent uptake of EBOV occurs by apoptotic mimicry. Additionally, TIM-1 enhanced infection of a wide range of enveloped viruses, including alphaviruses and a baculovirus. As further evidence of the critical role of enveloped-virion-associated PtdSer in TIM-1-mediated uptake, TIM-1 enhanced internalization of pseudovirions and virus-like proteins (VLPs) lacking a glycoprotein, providing evidence that TIM-1 and PtdSer-binding receptors can mediate virus uptake independent of a glycoprotein. These results provide evidence for a broad role of TIM-1 as a PtdSer-binding receptor that mediates enveloped-virus uptake. Utilization of PtdSer-binding receptors may explain the wide tropism of many of these viruses and provide new avenues for controlling their virulence. PMID:23698310

Analisis Persepsi Leadership dan Kewirausahaan dalam Mencapai Visi Teacherprenuership dan Entrepreneurship (Studi Kasus Mahasiswa Fakultas Agama Islam Universitas Muhammadiyah Magelang

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Ahwy Oktradiksa

2015-06-01

Full Text Available Penelitian ini bertujuan (1 untuk mengetahui persepsi leadership dalam mencapai visi teacherpreneurship dan entrepreneurship menurut mahasiswa Fakultas Agama Islam.(2 Untuk mengetahui analisis leadership dalam mencapai visi teacherpreneurship dan entrepreneurship di Fakultas Agama Islam. Penelitian ini adalah jenis penelitian lapangan studi kasus. Metode penelitian dengan analitis deskriptif, metode pengambilan sampel yang diambil dengan purposive sampling, teknik pengambilan data dengan metode observasi, wawancara dan kuisioner mengukur tingkat pemahaman. Hasil penelitian sebagai berikut : (1 Persepsi pada hakikatnya adalah proses kognitif yang dialami oleh setiap orang dalam memahami informasi tentang lingkungannya, merupakan suatu penafsiran yang unik terhadap situasi. Pandangan mahasiswa Fakultas Agama Islam Universitas Muhammadiyah Magelang tentang leadership/kepemimpinan dalam mewujudkan visi entreprenueship dan teacherprenuership sangatlah diperlukan karena suatu organisasi senantiasa menilai, baik sesama anggota maupun terhadap gaya yang diterapkan pemimpin, dan sebaliknya pemimpin memberi penilaian terhadap perilaku anggota. Sementara itu dalam kehidupan berorganisasi melakukan pengambilan keputusan yaitu dengan membuat pilihan dari dua alternatif atau lebih dimana semua keputusan menuntut penafsiran dan evaluasi terhadap informasi. (2 Berdasarkan hasil analisis persepsi yang dilakukan maka dapat dideksripsikan; (a Adanya persepsi leadership yang sifatnya berpengaruh positif berdasarkan indek persentase “setuju” dengan 6,57 % dan sangat setuju dengan 11,7 %, (b Adanya persepsi entreprenuership yang sifatnya berpengaruh positif berdasarkan indek persentase “setuju” dengan 3,0 % dan sangat setuju dengan 4,4 %, (c Adanya persepsi teacherprenuership yang sifatnya berpengaruh positif berdasarkan indek persentase “setuju” dengan 17,1 % dan sangat setuju dengan 16,2 %. Dari hasil penelitian ini bisa

Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer

Science.gov (United States)

Gao, Quanli; Yuan, Peng; Zhao, Peng; Yuan, Huijuan; Fan, Huijie; Li, Tiepeng; Qin, Peng; Han, Lu; Fang, Weijia; Suo, Zhenhe

2015-01-01

T-cell exhaustion represents a progressive loss of T-cell function. The inhibitory receptor PD-1 is known to negatively regulate CD8+ T cell responses directed against tumor antigen, but the blockades of PD-1 pathway didn't show the objective responses in patients with colorectal cancer (CRC). Thus, further exploring the molecular mechanism responsible for inducing T-cell dysfunction in CRC patients may reveal effective strategies for immune therapy. This study aims to characterize co-inhibitory receptors on T cells in CRC patients to identify novel targets for immunotherapy. In this study, peripheral blood samples from 20 healthy controls and 54 consented CRC patients, and tumor and matched paraneoplastic tissues from 7 patients with advanced CRC, subjected to multicolor flow cytometric analysis of the expression of PD-1 and Tim-3 receptors on CD8+ T cells. It was found that CRC patients presented with significantly higher levels of circulating Tim-3+PD-1+CD8+ T cells compared to the healthy controls (medians of 3.12% and 1.99%, respectively, p = 0.0403). A similar increase of Tim-3+PD-1+CD8+ T cells was also observed in the tumor tissues compared to paraneoplastic tussues. Tim-3+PD-1+CD8+ T cells in tumor tissues produced even less cytokine than that in paraneoplastic tissues. Functional ex vivo experiments showed that Tim-3+PD-1+CD8+ T cells produced significantly less IFN-γ than Tim-3−PD-1−CD8+ T cells, followed by Tim-3+PD-1−CD8+ T cells, and Tim-3−PD-1+CD8+ T cells, indicating a stronger inhibition of IFN-γ production of Tim-3+CD8+ T cells. It is also found in this study that Tim-3+PD-1+CD8+ T cell increase in circulation was correlated with clinical cancer stage but not histologic grade and serum concentrations of cancer biomarker CEA. Our results indicate that upregulation of the inhibitory receptor Tim-3 may restrict T cell responses in CRC patients, and therefore blockage of Tim-3 and thus restoring T cell responses may be a potential

Taming dendritic cells with TIM-3: Another immunosuppressive strategy by tumors

Science.gov (United States)

Patel, Jaina; Bozeman, Erica N.; Selvaraj, Periasamy

2013-01-01

The identification of TIM-3 expression on tumor associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells, however its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 mAb treated mice or mice depleted of all DCs which indicated that significant role played by TADCs inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings. PMID:23240746

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

LENUS (Irish Health Repository)

Vega-Carrascal, Isabel

2012-02-01

The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. It has been reported that proinflammatory cytokine dysregulation and neutrophil-dominated inflammation are the main causes of morbidity in cystic fibrosis (CF). However, the role of TIM receptors in CF has not been investigated. In this study, we demonstrated that TIM-3 is constitutively overexpressed in the human CF airway, suggesting a link between CF transmembrane conductance regulator (CFTR) function and TIM-3 expression. Blockade of CFTR function with the CFTR inhibitor-172 induced an upregulation of TIM-3 and its ligand galectin-9 in normal bronchial epithelial cells. We also established that TIM-3 serves as a functional receptor in bronchial epithelial cells, and physiologically relevant concentrations of galectin-9 induced TIM-3 phosphorylation, resulting in increased IL-8 production. In addition, we have demonstrated that both TIM-3 and galectin-9 undergo rapid proteolytic degradation in the CF lung, primarily because of neutrophil elastase and proteinase-3 activity. Our results suggest a novel intrinsic defect that may contribute to the neutrophil-dominated immune response in the CF airways.

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

LENUS (Irish Health Repository)

Vega-Carrascal, Isabel

2011-03-01

The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. It has been reported that proinflammatory cytokine dysregulation and neutrophil-dominated inflammation are the main causes of morbidity in cystic fibrosis (CF). However, the role of TIM receptors in CF has not been investigated. In this study, we demonstrated that TIM-3 is constitutively overexpressed in the human CF airway, suggesting a link between CF transmembrane conductance regulator (CFTR) function and TIM-3 expression. Blockade of CFTR function with the CFTR inhibitor-172 induced an upregulation of TIM-3 and its ligand galectin-9 in normal bronchial epithelial cells. We also established that TIM-3 serves as a functional receptor in bronchial epithelial cells, and physiologically relevant concentrations of galectin-9 induced TIM-3 phosphorylation, resulting in increased IL-8 production. In addition, we have demonstrated that both TIM-3 and galectin-9 undergo rapid proteolytic degradation in the CF lung, primarily because of neutrophil elastase and proteinase-3 activity. Our results suggest a novel intrinsic defect that may contribute to the neutrophil-dominated immune response in the CF airways.

Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.

Science.gov (United States)

Chacinska, Agnieszka; van der Laan, Martin; Mehnert, Carola S; Guiard, Bernard; Mick, David U; Hutu, Dana P; Truscott, Kaye N; Wiedemann, Nils; Meisinger, Chris; Pfanner, Nikolaus; Rehling, Peter

2010-01-01

Mitochondrial import of cleavable preproteins occurs at translocation contact sites, where the translocase of the outer membrane (TOM) associates with the presequence translocase of the inner membrane (TIM23) in a supercomplex. Different views exist on the mechanism of how TIM23 mediates preprotein sorting to either the matrix or inner membrane. On the one hand, two TIM23 forms were proposed, a matrix transport form containing the presequence translocase-associated motor (PAM; TIM23-PAM) and a sorting form containing Tim21 (TIM23(SORT)). On the other hand, it was reported that TIM23 and PAM are permanently associated in a single-entity translocase. We have accumulated distinct transport intermediates of preproteins to analyze the translocases in their active, preprotein-carrying state. We identified two different forms of active TOM-TIM23 supercomplexes, TOM-TIM23(SORT) and TOM-TIM23-PAM. These two supercomplexes do not represent separate pathways but are in dynamic exchange during preprotein translocation and sorting. Depending on the signals of the preproteins, switches between the different forms of supercomplex and TIM23 are required for the completion of preprotein import.

Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria.

Science.gov (United States)

Waegemann, Karin; Popov-Čeleketić, Dušan; Neupert, Walter; Azem, Abdussalam; Mokranjac, Dejana

2015-03-13

Translocation of the majority of mitochondrial proteins from the cytosol into mitochondria requires the cooperation of TOM and TIM23 complexes in the outer and inner mitochondrial membranes. The molecular mechanisms underlying this cooperation remain largely unknown. Here, we present biochemical and genetic evidence that at least two contacts from the side of the TIM23 complex play an important role in TOM-TIM23 cooperation in vivo. Tim50, likely through its very C-terminal segment, interacts with Tom22. This interaction is stimulated by translocating proteins and is independent of any other TOM-TIM23 contact known so far. Furthermore, the exposure of Tim23 on the mitochondrial surface depends not only on its interaction with Tim50 but also on the dynamics of the TOM complex. Destabilization of the individual contacts reduces the efficiency of import of proteins into mitochondria and destabilization of both contacts simultaneously is not tolerated by yeast cells. We conclude that an intricate and coordinated network of protein-protein interactions involving primarily Tim50 and also Tim23 is required for efficient translocation of proteins across both mitochondrial membranes. Copyright © 2014 Elsevier Ltd. All rights reserved.

TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.

Directory of Open Access Journals (Sweden)

Stephanie Jemielity

2013-03-01

Full Text Available Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4 specifically bind phosphatidylserine (PS. TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengue virus. Here we show that TIM1 promotes infection of retroviruses and virus-like particles (VLPs pseudotyped with a range of viral entry proteins, in particular those from the filovirus, flavivirus, New World arenavirus and alphavirus families. TIM1 also robustly enhanced the infection of replication-competent viruses from the same families, including dengue, Tacaribe, Sindbis and Ross River viruses. All interactions between TIM1 and pseudoviruses or VLPs were PS-mediated, as demonstrated with liposome blocking and TIM1 mutagenesis experiments. In addition, other PS-binding proteins, such as Axl and TIM4, promoted infection similarly to TIM1. Finally, the blocking of PS receptors on macrophages inhibited the entry of Ebola VLPs, suggesting that PS receptors can contribute to infection in physiologically relevant cells. Notably, infection mediated by the entry proteins of Lassa fever virus, influenza A virus and SARS coronavirus was largely unaffected by TIM1 expression. Taken together our data show that TIM1 and related PS-binding proteins promote infection of diverse families of enveloped viruses, and may therefore be useful targets for broad-spectrum antiviral therapies.

Tim Berners-Lee, World Wide Web inventor

CERN Multimedia

1994-01-01

Former physicist, Tim Berners-Lee invented the World Wide Web as an essential tool for high energy physics at CERN from 1989 to 1994. Together with a small team he conceived HTML, http, URLs, and put up the first server and the first 'what you see is what you get' browser and html editor. Tim is now Director of the Web Consortium W3C, the International Web standards body based at INRIA, MIT and Keio University.

Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors.

Science.gov (United States)

Patel, Jaina; Bozeman, Erica N; Selvaraj, Periasamy

2012-12-01

Evaluation of: Chiba S, Baghdadi M, Akiba H et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat. Immunol. 13, 832-842 (2012). The identification of TIM-3 expression on tumor-associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells; however, its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid-mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 monoclonal antibody-treated mice or mice depleted of all DCs, which indicated that a significant role is played by TADCs in inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings.

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.

Science.gov (United States)

Meertens, Laurent; Carnec, Xavier; Lecoin, Manuel Perera; Ramdasi, Rasika; Guivel-Benhassine, Florence; Lew, Erin; Lemke, Greg; Schwartz, Olivier; Amara, Ali

2012-10-18

Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, the molecular interactions mediating DV entry are poorly understood. We determined that TIM and TAM proteins, two receptor families that mediate the phosphatidylserine (PtdSer)-dependent phagocytic removal of apoptotic cells, serve as DV entry factors. Cells poorly susceptible to DV are robustly infected after ectopic expression of TIM or TAM receptors. Conversely, DV infection of susceptible cells is inhibited by anti-TIM or anti-TAM antibodies or knockdown of TIM and TAM expression. TIM receptors facilitate DV entry by directly interacting with virion-associated PtdSer. TAM-mediated infection relies on indirect DV recognition, in which the TAM ligand Gas6 acts as a bridging molecule by binding to PtdSer within the virion. This dual mode of virus recognition by TIM and TAM receptors reveals how DVs usurp the apoptotic cell clearance pathway for infectious entry. Copyright © 2012 Elsevier Inc. All rights reserved.

Tim-3 Up-regulation in Patients with Gastric Cancer and Peptic Ulcer Disease

Science.gov (United States)

Naghavi-Alhosseini, Mahdieh; Tehrani, Mohsen; Ajami, Abolghasem; Rafiei, Alireza; Taghvaei, Tarang; Vahedi-Larijani, Laleh; Hossein-Nataj, Hadi; Asgarian-Omran, Hossein

2017-01-01

Background: T-cell immunoglobulin and mucin domain protein-3 (Tim-3), an inhibitory immunoregulatory receptor, has been recently implicated in tumor biology and tumor-associated immune suppression. In the present study, expression of Tim-3 was evaluated in gastric cancer (GC) and peptic ulcer disease (PUD) at both mRNA and protein levels. Methods: A total of 133 gastric tissue biopsies, comprising 43 from GC cases, 48 from PUD and 42 from non-ulcer dyspepsia (NUD) serving as controls were collected. Additionally, non-neoplastic adjacent tissue biopsies were also obtained from 6 patients with GC. Infection with Helicobacter pylori was determined by the rapid urease test for all participants and H&E staining was conducted for GC and PUD patients. Tim-3 relative mRNA expression was determined by SYBR Green based Real-Time PCR using β-actin as a reference gene. Tim-3 protein expression was also studied by immunohistochemistry in 7 GC, 7 PUD and 10 NUD tissue samples. Results: Tim-3 was expressed at higher levels in GC (p=0.030) and PUD (p=0.022) cases compared to he NUD group. Among paired samples obtained from gastric cancer patients, tumor tissues showed elevated Tim-3 expression (p=0.019) in comparison with adjacent non-neoplastic biopsies. Tim-3 mRNA findings were supported by detection of more Tim-3 protein in cancerous (p=0.002) and ulcerative (p=0.01) tissues than in controls. Tim-3 was similarly expressed in H. pylori positive and negative cases. Conclusion: Higher Tim-3 expression in patients with gastric cancer and peptic ulcer implies that it might be involved in immune regulation and establishment of these gastrointestinal diseases. Targeted immunotherapy by blocking of inhibitory receptors like Tim-3 could be a promising approach for gastric cancer treatment. PMID:28441784

Analysis of TIMS performance subjected to simulated wind blast

Science.gov (United States)

Jaggi, S.; Kuo, S.

1992-01-01

The results of the performance of the Thermal Infrared Multispectral Scanner (TIMS) when it is subjected to various wind conditions in the laboratory are described. Various wind conditions were simulated using a 24 inch fan or combinations of air jet streams blowing toward either or both of the blackbody surfaces. The fan was used to simulate a large volume of air flow at moderate speeds (up to 30 mph). The small diameter air jets were used to probe TIMS system response in reaction to localized wind perturbations. The maximum nozzle speed of the air jet was 60 mph. A range of wind directions and speeds were set up in the laboratory during the test. The majority of the wind tests were conducted under ambient conditions with the room temperature fluctuating no more than 2 C. The temperature of the high speed air jet was determined to be within 1 C of the room temperature. TIMS response was recorded on analog tape. Additional thermistor readouts of the blackbody temperatures and thermocouple readout of the ambient temperature were recorded manually to be compared with the housekeeping data recorded on the tape. Additional tests were conducted under conditions of elevated and cooled room temperatures. The room temperature was varied between 19.5 to 25.5 C in these tests. The calibration parameters needed for quantitative analysis of TIMS data were first plotted on a scanline-by-scanline basis. These parameters are the low and high blackbody temperature readings as recorded by the TIMS and their corresponding digitized count values. Using these values, the system transfer equations were calculated. This equation allows us to compute the flux for any video count by computing the slope and intercept of the straight line that relates the flux to the digital count. The actual video of the target (the lab floor in this case) was then compared with a simulated target. This simulated target was assumed to be a blackbody at emissivity of .95 degrees and the temperature was

Tim Berners-Lee and Kofi Annan during the WSIS

CERN Multimedia

Patrice Loïez

2003-01-01

During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Tim Berners-Lee and Kofi Annan during the WSIS

CERN Multimedia

Patrice Loïez

2003-01-01

During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee, W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Architecture of the TIM23 inner mitochondrial translocon and interactions with the matrix import motor.

Science.gov (United States)

Ting, See-Yeun; Schilke, Brenda A; Hayashi, Masaya; Craig, Elizabeth A

2014-10-10

Translocation of proteins from the cytosol across the mitochondrial inner membrane is driven by action of the matrix-localized multi-subunit import motor, which is associated with the TIM23 translocon. The architecture of the import apparatus is not well understood. Here, we report results of site-specific in vivo photocross-linking along with genetic and coimmunoprecipitation analyses dissecting interactions between import motor subunits and the translocon. The translocon is composed of the two integral membrane proteins Tim23 and Tim17, each containing four membrane-spanning segments. We found that Tim23 having a photoactivatable cross-linker in the matrix exposed loop between transmembrane domains 1 and 2 (loop 1) cross-linked to Tim44. Alterations in this loop destabilized interaction of Tim44 with the translocon. Analogously, Tim17 having a photoactivatable cross-linker in the matrix exposed loop between transmembrane segments 1 and 2 (loop 1) cross-linked to Pam17. Alterations in this loop caused destabilization of the interaction of Pam17 with the translocon. Substitution of individual photoactivatable residues in Tim44 and Pam17 in regions we previously identified as important for translocon association resulted in cross-linking to Tim23 and Tim17, respectively. Our results are consistent with a model in which motor association is achieved via interaction of Tim23 with Tim44, which serves as a scaffold for association of other motor components, and of Tim17 with Pam17. As both Tim44 and Pam17 have been implicated as regulatory subunits of the motor, this positioning is conducive for responding to conformational changes in the translocon upon a translocating polypeptide entering the channel. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

PERANCANGAN SISTEM INFORMASI PERPUSTAKAAN MENGGUNAKAN BARCODE PADA FAKULTAS ILMU KOMPUTER UNIVERSITAS LANCANG KUNING

Directory of Open Access Journals (Sweden)

Fery Wongso Fery Wongso

2015-09-01

Full Text Available Abstrak : Sistem informasi Perpustakaan merupakan unit kerja yang mengumpulkan, menyimpan, memelihara dan mengelola pemanfaatan koleksi bahan pustaka dengan menggunakan sistem .  Sistem informasi sudah banyak digunakan pada suatu tempat dengan berbagai macam teknologi dan sistem. Tujuan dari penulisan ini adalah untuk merancang sistem informasi perpustakaan yang ada pada Fakultas Ilmu Komputer Universitas Lancang Kuning PekanbaruAgar menjadi terkomputerisasi dan memudahkan bagian staf perpustakaan dalam mengolah data buku, data anggota, peminjaman buku dan pengembalian buku. agar cepat dan akurat dengan menggunakan suatu aplikasi PHP untuk dapat membantu dalam pengolahan data buku, data anggota, peminjaman buku dan proses pengembalian buku pada Fakultas Ilmu Komputer Universitas Lancang Kuning Pekanbaru. Abstract : Library Information Systems is a business unit that collect, store, preserve and manage the utilization of library collections using the system. The information system has been widely used in a place with a variety of technologies and systems. The purpose of this paper is to design a library of existing information systems at the Faculty of Computer Science University of Lancang Kuning PekanbaruIn order to be computerized and facilitate the passage of library staff in processing the data book, data members, borrowing books and returning books. to quickly and accurately using a PHP application to be able to assist in the processing of the data book, data members, borrowing books and the process of returning books at the Faculty of Computer Science University of Lancang Kuning Pekanbaru. Keywords : Information Systems, Computer Science Faculty Library

Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy

DEFF Research Database (Denmark)

Meggyes, Matyas; Miko, Eva; Polgar, Beata

2014-01-01

PROBLEM: The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/TIM-3 pathway as an important...... negative regulator of Th1 immunity and tolerance induction. Data about the TIM-3/Gal-9 pathway in the pathogenesis of human diseases is emerging, but their possible role during human pregnancy is not precisely known. The aim of our study was to investigate the number, phenotype and functional activity...... of TIM-3+ peripheral blood mononuclear cells during healthy human pregnancy. METHODS OF STUDY: 57 healthy pregnant women [first trimester (n = 16); second trimester (n = 19); third trimester (n = 22)] and 30 non-pregnant controls were enrolled in the study. We measured the surface expression of TIM-3...

Perilaku Mahasiswa Dalam Meminimalisir Penggunaan Kantong Plastik Dan Styrofoam Di Fakultas Kesehatan Masyarakat Universitas Sumatera Utara Tahun 2017

OpenAIRE

Sihombing, Margaretha Pratiwi

2017-01-01

131000630 Penggunaan plastik dan styrofoam sebagai kemasan makanan merupakan perilaku yang menyebabkan kerusakan dan pencemaran lingkungan. Penggunaan plastik dan styrofoam meningkat secara signifikan dan banyak digunakan sehingga menyebabkan masalah kesehatan dan lingkungan. Penelitian ini bertujuan untuk mengetahui perilaku mahasiswa dalam meminimalisir penggunaan kantong plastik dan styrofoam di Fakultas Kesehatan Masyarakat Universitas Sumatera Utara tahun 2017. Je...

A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9

International Nuclear Information System (INIS)

Weyer, Philipp S. van de; Muehlfeit, Michael; Klose, Christoph; Bonventre, Joseph V.; Walz, Gerd; Kuehn, E. Wolfgang

2006-01-01

Tim-3 is a member of the TIM family of proteins (T-cell immunoglobulin mucin) involved in the regulation of CD4+ T-cells. Tim-3 is a T H 1-specific type 1 membrane protein and regulates T H 1 proliferation and the development of tolerance. Binding of galectin-9 to the extracellular domain of Tim-3 results in apoptosis of T H 1 cells, but the intracellular pathways involved in the regulatory function of Tim-3 are unknown. Unlike Tim-1, which is expressed in renal epithelia and cancer, Tim-3 has not been described in cells other than neuronal or T-cells. Using RT-PCR we demonstrate that Tim-3 is expressed in malignant and non-malignant epithelial tissues. We have cloned Tim-3 from an immortalized liver cell carcinoma line and identified a highly conserved tyrosine in the intracellular tail of Tim-3 (Y265). We demonstrate that Y265 is specifically phosphorylated in vivo by the interleukin inducible T cell kinase (ITK), a kinase which is located in close proximity of the TIM genes on the allergy susceptibility locus 5q33.3. Stimulation of Tim-3 by its ligand galectin-9 results in increased phosphorylation of Y265, suggesting that this tyrosine residue plays an important role in downstream signalling events regulating T-cell fate. Given the role of TIM proteins in autoimmunity and cancer, the conserved SH2 binding domain surrounding Y265 could represent a possible target site for pharmacological intervention

The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism.

Science.gov (United States)

Goldman, Aaron David; Beatty, Joshua T; Landweber, Laura F

2016-01-01

The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture that is present in approximately 10% of all enzymes. It is generally assumed that this ubiquity in modern proteomes reflects an essential historical role in early protein-mediated metabolism. Here, we provide quantitative and comparative analyses to support several hypotheses about the early importance of the TIM barrel architecture. An information theoretical analysis of protein structures supports the hypothesis that the TIM barrel architecture could arise more easily by duplication and recombination compared to other mixed α/β structures. We show that TIM barrel enzymes corresponding to the most taxonomically broad superfamilies also have the broadest range of functions, often aided by metal and nucleotide-derived cofactors that are thought to reflect an earlier stage of metabolic evolution. By comparison to other putatively ancient protein architectures, we find that the functional diversity of TIM barrel proteins cannot be explained simply by their antiquity. Instead, the breadth of TIM barrel functions can be explained, in part, by the incorporation of a broad range of cofactors, a trend that does not appear to be shared by proteins in general. These results support the hypothesis that the simple and functionally general TIM barrel architecture may have arisen early in the evolution of protein biosynthesis and provided an ideal scaffold to facilitate the metabolic transition from ribozymes, peptides, and geochemical catalysts to modern protein enzymes.

Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria.

Science.gov (United States)

Mokranjac, Dejana; Sichting, Martin; Popov-Celeketić, Dusan; Mapa, Koyeli; Gevorkyan-Airapetov, Lada; Zohary, Keren; Hell, Kai; Azem, Abdussalam; Neupert, Walter

2009-03-01

Transport of essentially all matrix and a number of inner membrane proteins is governed, entirely or in part, by N-terminal presequences and requires a coordinated action of the translocases of outer and inner mitochondrial membranes (TOM and TIM23 complexes). Here, we have analyzed Tim50, a subunit of the TIM23 complex that is implicated in transfer of precursors from TOM to TIM23. Tim50 is recruited to the TIM23 complex via Tim23 in an interaction that is essentially independent of the rest of the translocase. We find Tim50 in close proximity to the intermembrane space side of the TOM complex where it recognizes both types of TIM23 substrates, those that are to be transported into the matrix and those destined to the inner membrane, suggesting that Tim50 recognizes presequences. This function of Tim50 depends on its association with TIM23. We conclude that the efficient transfer of precursors between TOM and TIM23 complexes requires the concerted action of Tim50 with Tim23.

Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm.

Science.gov (United States)

Younan, Patrick; Iampietro, Mathieu; Nishida, Andrew; Ramanathan, Palaniappan; Santos, Rodrigo I; Dutta, Mukta; Lubaki, Ndongala Michel; Koup, Richard A; Katze, Michael G; Bukreyev, Alexander

2017-09-26

Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a "cytokine storm." Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1) has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1 -/- mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected. Tim-1 -/- mice exhibited a modified inflammatory response as evidenced by changes in serum cytokines and activation of T helper subsets. A series of in vitro assays based on the Tim-1 expression profile on T cells demonstrated that despite the apparent absence of detectable viral replication in T lymphocytes, EBOV directly binds to isolated T lymphocytes in a phosphatidylserine-Tim-1-dependent manner. Exposure to EBOV resulted in the rapid development of a CD4 Hi CD3 Low population, non-antigen-specific activation, and cytokine production. Transcriptome and Western blot analysis of EBOV-stimulated CD4 + T cells confirmed the induction of the Tim-1 signaling pathway. Furthermore, comparative analysis of transcriptome data and cytokine/chemokine analysis of supernatants highlight the similarities associated with EBOV-stimulated T cells and the onset of a cytokine storm. Flow cytometry revealed virtually exclusive binding and activation of central memory CD4 + T cells. These findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of EVD. IMPORTANCE Ebola virus infection is characterized by a massive release of inflammatory mediators, which has come to be known as a cytokine storm. The severity of the cytokine storm is

PERBEDAAN WAKTU REAKSI PADA BERBAGAI DURASI LATIHAN DAN INDEKS MASSA TUBUH PADA TIM FUTSAL FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA TAHUN 2014

Directory of Open Access Journals (Sweden)

I Putu Gede Windhu Saputra

2015-06-01

Full Text Available Futsal merupakan salah satu olahraga permainan bola yang kini makin digemari oleh banyak orang. Permainan futsal membutuhkan kondisi jasmani, kemampuan menggiring bola, mencetak gol, dan menghadang lawan yang baik. Berbagai kemampuan tersebut membutuhkan latihan rutin, indeks massa tubuh (IMT, serta waktu reaksi yang optimal agar dapat bermain dengan baik. Penelitian ini ingin melihat bagaimana perbedaan waktu reaksi pada berbagai durasi latihan dan IMT pada pemain tim futsal FK UNUD. Penelitian ini dilakukan dengan metode analisis potong lintang dengan melihat perbedaan waktu reaksi berdasarkan durasi latihan dan IMT. Dari hasil uji T menunjukkan tidak didapatkan perbedaan bermakna dari rata-rata waktu reaksi (p>0,05 antara pemain yang berlatih kurang dari 5 jam per minggu (266,67 milidetik ± 22,223 dibandingkan dengan pemain yang berlatih lebih dari 5 jam per minggu (305,67 milidetik ± 45,247. Tidak didapatkan pula perbedaan signifikan (p>0,05 antara pemain yang memiliki indeks massa tubuh dibawah 25 kg/m2 (283,80 milidetik ± 37,067 dan yang memiliki indeks massa tubuh lebih dari sama dengan 25 kg/m2 (302,40 milidetik ± 51,897. Kesimpulan dari penelitian ini tidak didapatkan perbedaan waktu reaksi yang signifikan antara kelompok pemain yang berlatih kurang dari 5 jam per minggu dibandingkan dengan kelompok pemain yang berlatih lebih dari sama dengan 5 jam per minggu. Tidak didapatkan perbedaan waktu reaksi yang signifikan pada kelompok pemain dengan IMT kurang dari 25 kg/m2 dibandingkan dengan kelompok pemain dengan IMT lebih dari sama dengan 25 kg/m2.    

TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

Directory of Open Access Journals (Sweden)

Wenwen Du

2017-03-01

Full Text Available Cancer immunotherapy has produced impressive clinical results in recent years. Despite the success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4 and programmed death receptor 1 (PD-1, a large portion of cancer patients have not yet benefited from this novel therapy. T cell immunoglobulin and mucin domain 3 (TIM-3 has been shown to mediate immune tolerance in mouse models of infectious diseases, alloimmunity, autoimmunity, and tumor Immunity. Thus, targeting TIM-3 emerges as a promising approach for further improvement of current immunotherapy. Despite a large amount of experimental data showing an immune suppressive function of TIM-3 in vivo, the exact mechanisms are not well understood. To enable effective targeting of TIM-3 for tumor immunotherapy, further in-depth mechanistic studies are warranted. These studies will also provide much-needed insight for the rational design of novel combination therapy with other checkpoint blockers. In this review, we summarize key evidence supporting an immune regulatory role of TIM-3 and discuss possible mechanisms of action.

PERILAKU KONSUMSI MIE INSTAN MAHASISWA FAKULTAS ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH DAN JURUSAN GIZI POLTEKKES KEMENKES PONTIANAK

Directory of Open Access Journals (Sweden)

Rochmawati Rochmawati

2015-11-01

Full Text Available Abstract: Instant Noodle Consumption Behavior Among Students Of Health Sciences Faculty Of Muhammadiyah University Pontianak And Nutrition Department Of Health Polytechnic Of Health Ministry Pontianak. This study aimed at determining the factors associated with instant noodle consumption behaviour among students of Health Sciences Faculty of Muhammadiyah University of Pontianak and Nutrition Department of Health Polytechnic of Health Ministry of Pontianak. Using cross-sectional design, this study employed 145 students as the samples and were selected by using simple random sampling. The statistical test used was chi-square test. The study revealed that there were no significant correlation of  nutritional knowledge (p = 1.000, PR = 1.004 with 95% CI = 0.712 to 1.415, food safety(p = 0.064, PR =0,646with 95% CI = 0.407 to 1.025, media exposure (p = 0.139, PR = 1.419 with 95% CI = 0.911 to 2.211, inhabitancy (p = 0.851, PR = 0.932 with 95% CI = 0.646 to 1.344 and instant noodles consumption behavior among students of Health Sciences Faculty of Muhammadiyah University Pontianak and Nutrition Department of Health Polytechnic of Health Ministry Pontianak. Abstrak : Perilaku Konsumsi Mie Instan Mahasiswa Fakultas Ilmu Kesehatan Universitas Muhammadiyah Dan Jurusan Gizi Poltekkes Kemenkes Pontianak. Tujuan penelitian yaitu untuk mengetahui faktor-faktor yang berhubungan dengan perilaku konsumsi mie instan pada mahasiswa  Fakultas Ilmu Kesehatan Universitas Muhammadiyah Pontianak dan Jurusan Gizi Poltekkes Kemenkes Pontianak. Jumlah sampel yaitu 145 orang dengan penentuan sampel secara Simple random sampling dan menggunakan desain penelitian cross sectional. Uji statistik yang digunakan adalah Chi-square. Hasil penelitian menunjukkan tidak terdapat hubungan yang bermakna antara pengetahuan gizi (p = 1,000, PR = 1,004 dengan CI 95% = 0,712-1,415, keamanan pangan (p = 0,064, PR = 0,646 dengan CI 95% =0,407-1,025, keterpaparan media (p = 0,139, PR = 1

Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm

Directory of Open Access Journals (Sweden)

Patrick Younan

2017-09-01

Full Text Available Ebola virus (EBOV disease (EVD results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1 has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1−/− mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected. Tim-1−/− mice exhibited a modified inflammatory response as evidenced by changes in serum cytokines and activation of T helper subsets. A series of in vitro assays based on the Tim-1 expression profile on T cells demonstrated that despite the apparent absence of detectable viral replication in T lymphocytes, EBOV directly binds to isolated T lymphocytes in a phosphatidylserine–Tim-1-dependent manner. Exposure to EBOV resulted in the rapid development of a CD4Hi CD3Low population, non-antigen-specific activation, and cytokine production. Transcriptome and Western blot analysis of EBOV-stimulated CD4+ T cells confirmed the induction of the Tim-1 signaling pathway. Furthermore, comparative analysis of transcriptome data and cytokine/chemokine analysis of supernatants highlight the similarities associated with EBOV-stimulated T cells and the onset of a cytokine storm. Flow cytometry revealed virtually exclusive binding and activation of central memory CD4+ T cells. These findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of EVD.

Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.

Science.gov (United States)

Jang, A Reum; Moravcevic, Katarina; Saez, Lino; Young, Michael W; Sehgal, Amita

2015-02-01

Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA repression in the molecular feedback loop. In Drosophila, nuclear entry of the clock proteins, PERIOD (PER) and TIMELESS (TIM), is tightly controlled, and impairments of this process produce profound behavioral phenotypes. We report here that nuclear entry of PER-TIM in clock cells, and consequently behavioral rhythms, require a specific member of a classic nuclear import pathway, Importin α1 (IMPα1). In addition to IMPα1, rhythmic behavior and nuclear expression of PER-TIM require a specific nuclear pore protein, Nup153, and Ran-GTPase. IMPα1 can also drive rapid and efficient nuclear expression of TIM and PER in cultured cells, although the effect on PER is mediated by TIM. Mapping of interaction domains between IMPα1 and TIM/PER suggests that TIM is the primary cargo for the importin machinery. This is supported by attenuated interaction of IMPα1 with TIM carrying a mutation previously shown to prevent nuclear entry of TIM and PER. TIM is detected at the nuclear envelope, and computational modeling suggests that it contains HEAT-ARM repeats typically found in karyopherins, consistent with its role as a co-transporter for PER. These findings suggest that although PER is the major timekeeper of the clock, TIM is the primary target of nuclear import mechanisms. Thus, the circadian clock uses specific components of the importin pathway with a novel twist in that TIM serves a karyopherin-like role for PER.

Awards: New Year Knighthood for Tim Berners-Lee

CERN Multimedia

2004-01-01

Tim Berners-Lee has been awarded his country's highest honour - a knighthood - in the UK's New Year Honours list for his work while at CERN on the World Wide Web. In the same honours list, Roger Cashmore has been made a Companion of the Order of St Michael and St George (CMG) "for his services to international co-operation in particle physics". Cashmore was CERN's Director for Collider Programmes from 1999-2003, and is now Principal of Brasenose College, Oxford. Tim Berners-Lee stands in front of the first web server at Palexpo during the World Summit on the Information Society.

Hubungan Stres dengan Kejadian Dismenore Primer pada Mahasiswi Pendidikan Dokter Fakultas Kedokteran Universitas Andalas

Directory of Open Access Journals (Sweden)

Diana Sari

2015-05-01

Full Text Available AbstrakDismenore primer merupakan nyeri menstruasi yang dijumpai tanpa kelainan yang nyata pada alat-alat genital. Lebih dari 50% wanita mengalami dismenore primer dan 15% diantaranya mengalami nyeri yang hebat.Tujuan penelitian ini adalah untuk menentukan hubungan tingkat stres dengan derajat dismenore primer. Penelitian dilakukan pada mahasiswi pendidikan dokter Fakultas Kedokteran Universitas Andalas angkatan 2009 dan 2010. Desain penelitian ini menggunakan cross sectional study dengan jumlah subjek 165 orang. Pengumpulan data dari responden dilakukan dengan wawancara terpimpin (pengisian kuesioner. Analisa statistik yang digunakan adalah uji chi-square dan uji koefisien korelasi sederhana. Uji chi-square menunjukan ada hubungan yang bermakna antara stres dengan kejadian dismenore primer dan uji statistik koefisien korelasi sederhana menunjukkan ada hubungan yang bermakna dengan korelasi agak lemah antara tingkat stres dengan derajat dismenore primer.Kata kunci: stres, dismenore primer, mahasiswi fakultas kedokteran AbstractPrimary dysmenorrhoea is menstrual pain founded without real abnormalities in genital organs. More than 50% woman experiance it and 15% had severe pain. The objective of this study was to determine relationship between stress and primary dysmenorrhoea. Research was executed to education medical female students medical faculty of Andalas University class of 2009 and 2010. This research use cross sectional study design with 165 subjects. Data was collected by guided interview. Statistic analysis use chi-square test and simple correlation test. Chi-square test show there is significant relationship between stress and primary dysmenorrhoea and simple coefficient test show there is weak correlation between stress levels and degree of primary dysmenorrhoea.Keywords: stress, primary dysmenorrhoea, female student of medical faculty

Tim Berners-Lee at the RSIS conference from 8-9 December 2003.

CERN Multimedia

Patrice Loiez

2003-01-01

Tim Berners-Lee participated in the Role of Science in the Information Society conference held at CERN from 8-9 December 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

TIM, a ray-tracing program for METATOY research and its dissemination

Science.gov (United States)

Lambert, Dean; Hamilton, Alasdair C.; Constable, George; Snehanshu, Harsh; Talati, Sharvil; Courtial, Johannes

2012-03-01

TIM (The Interactive METATOY) is a ray-tracing program specifically tailored towards our research in METATOYs, which are optical components that appear to be able to create wave-optically forbidden light-ray fields. For this reason, TIM possesses features not found in other ray-tracing programs. TIM can either be used interactively or by modifying the openly available source code; in both cases, it can easily be run as an applet embedded in a web page. Here we describe the basic structure of TIM's source code and how to extend it, and we give examples of how we have used TIM in our own research. Program summaryProgram title: TIM Catalogue identifier: AEKY_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKY_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 124 478 No. of bytes in distributed program, including test data, etc.: 4 120 052 Distribution format: tar.gz Programming language: Java Computer: Any computer capable of running the Java Virtual Machine (JVM) 1.6 Operating system: Any; developed under Mac OS X Version 10.6 RAM: Typically 145 MB (interactive version running under Mac OS X Version 10.6) Classification: 14, 18 External routines: JAMA [1] (source code included) Nature of problem: Visualisation of scenes that include scene objects that create wave-optically forbidden light-ray fields. Solution method: Ray tracing. Unusual features: Specifically designed to visualise wave-optically forbidden light-ray fields; can visualise ray trajectories; can visualise geometric optic transformations; can create anaglyphs (for viewing with coloured "3D glasses") and random-dot autostereograms of the scene; integrable into web pages. Running time: Problem-dependent; typically seconds for a simple scene.

Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4.

Science.gov (United States)

Tietjen, Gregory T; Gong, Zhiliang; Chen, Chiu-Hao; Vargas, Ernesto; Crooks, James E; Cao, Kathleen D; Heffern, Charles T R; Henderson, J Michael; Meron, Mati; Lin, Binhua; Roux, Benot; Schlossman, Mark L; Steck, Theodore L; Lee, Ka Yee C; Adams, Erin J

2014-04-15

Recognition of phosphatidylserine (PS) lipids exposed on the extracellular leaflet of plasma membranes is implicated in both apoptotic cell removal and immune regulation. The PS receptor T cell immunoglobulin and mucin-domain-containing molecule 4 (Tim4) regulates T-cell immunity via phagocytosis of both apoptotic (high PS exposure) and nonapoptotic (intermediate PS exposure) activated T cells. The latter population must be removed at lower efficiency to sensitively control immune tolerance and memory cell population size, but the molecular basis for how Tim4 achieves this sensitivity is unknown. Using a combination of interfacial X-ray scattering, molecular dynamics simulations, and membrane binding assays, we demonstrate how Tim4 recognizes PS in the context of a lipid bilayer. Our data reveal that in addition to the known Ca(2+)-coordinated, single-PS binding pocket, Tim4 has four weaker sites of potential ionic interactions with PS lipids. This organization makes Tim4 sensitive to PS surface concentration in a manner capable of supporting differential recognition on the basis of PS exposure level. The structurally homologous, but functionally distinct, Tim1 and Tim3 are significantly less sensitive to PS surface density, likely reflecting the differences in immunological function between the Tim proteins. These results establish the potential for lipid membrane parameters, such as PS surface density, to play a critical role in facilitating selective recognition of PS-exposing cells. Furthermore, our multidisciplinary approach overcomes the difficulties associated with characterizing dynamic protein/membrane systems to reveal the molecular mechanisms underlying Tim4's recognition properties, and thereby provides an approach capable of providing atomic-level detail to uncover the nuances of protein/membrane interactions.

Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3).

Science.gov (United States)

Homayouni, Vida; Ganjalikhani-Hakemi, Mazdak; Rezaei, Abbas; Khanahmad, Hossein; Behdani, Mahdi; Lomedasht, Fatemeh Kazemi

2016-11-01

As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. We immunized a camel with TIM-3 antigen and then, synthesized a VHH phage: mid library from its B cell's transcriptome using nested PCR. Library selection against TIM-3antigen was performed in three rounds of panning. Using phage-ELISA, the most reactive colonies were selected for sub-cloning in soluble protein expression vectors. The Nanobody was purified and confirmed with a nickel-nitrilotriacetic acid (Ni-NTA) column, SDS-PAGE and Western blotting. A flowcytometric analysis was performed to analyze the binding and biologic activities of theTIM-3 specific nanobody with TIM-3 expressing HL-60 and HEK cell lines. Specific 15kD band representing for nanobody was observed on the gel and confirmed with Western blotting. The nanobody showed significant specific immune-reactivity against TIM-3 with a relatively high binding affinity. The nanobody significantly suppressed the proliferation of TIM-3 expressing HL-60 cell line. Finally, we successfully prepared a functional anti-humanTIM-3 specific nanobody with a high affinity and an anti-proliferative activity on an AML cell line in vitro.

Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3

Directory of Open Access Journals (Sweden)

Vida Homayouni

2016-11-01

Full Text Available Objective(s: As T-cell immunoglobulin and mucin domain 3 (TIM-3 is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Methods:We immunized a camel with TIM-3 antigen and then, synthesized a VHH phagemid library from its B cell’s transcriptome using nested PCR. Library selection against TIM-3antigen was performed in three rounds of panning. Using phage-ELISA, the most reactive colonies were selected for sub-cloning in soluble protein expression vectors. The Nanobody was purified and confirmed with a nickel-nitrilotriacetic acid (Ni-NTA column, SDS-PAGE and Western blotting. A flowcytometric analysis was performed to analyze the binding and biologic activities of theTIM-3 specific nanobody with TIM-3 expressing HL-60 and HEK cell lines. Results:Specific 15kD band representing for nanobody was observed on the gel and confirmed with Western blotting. The nanobody showed significant specific immune-reactivity against TIM-3 with a relatively high binding affinity. The nanobody significantly suppressed the proliferation of TIM-3 expressing HL-60 cell line. Conclusion: Finally, we successfully prepared a functional anti-humanTIM-3 specific nanobody with a high affinity and an anti-proliferative activity on an AML cell line in vitro.

A polymorphism of the TIM-1 IgV domain: implications for the susceptibility to filovirus infection.

Science.gov (United States)

Kuroda, Makoto; Fujikura, Daisuke; Noyori, Osamu; Kajihara, Masahiro; Maruyama, Junki; Miyamoto, Hiroko; Yoshida, Reiko; Takada, Ayato

2014-12-12

Filoviruses, including Ebola and Marburg viruses, cause severe hemorrhagic fever in humans and nonhuman primates with mortality rates of up to 90%. Human T-cell immunoglobulin and mucin domain 1 (TIM-1) is one of the host proteins that have been shown to promote filovirus entry into cells. In this study, we cloned TIM-1 genes from three different African green monkey kidney cell lines (Vero E6, COS-1, and BSC-1) and found that TIM-1 of Vero E6 had a 23-amino acid deletion and 6 amino acid substitutions compared with those of COS-1 and BSC-1. Interestingly, Vero E6 TIM-1 had a greater ability to promote the infectivity of vesicular stomatitis viruses pseudotyped with filovirus glycoproteins than COS-1-derived TIM-1. We further found that the increased ability of Vero E6 TIM-1 to promote virus infectivity was most likely due to a single amino acid difference between these TIM-1s. These results suggest that a polymorphism of the TIM-1 molecules is one of the factors that influence cell susceptibility to filovirus infection, providing a new insight into the molecular basis for the filovirus host range. Copyright © 2014 Elsevier Inc. All rights reserved.

Airborne Thermal Infrared Multispectral Scanner (TIMS) images over disseminated gold deposits, Osgood Mountains, Humboldt County, Nevada

Science.gov (United States)

Krohn, M. Dennis

1986-01-01

The U.S. Geological Survey (USGS) acquired airborne Thermal Infrared Multispectral Scanner (TIMS) images over several disseminated gold deposits in northern Nevada in 1983. The aerial surveys were flown to determine whether TIMS data could depict jasperoids (siliceous replacement bodies) associated with the gold deposits. The TIMS data were collected over the Pinson and Getchell Mines in the Osgood Mountains, the Carlin, Maggie Creek, Bootstrap, and other mines in the Tuscarora Mountains, and the Jerritt Canyon Mine in the Independence Mountains. The TIMS data seem to be a useful supplement to conventional geochemical exploration for disseminated gold deposits in the western United States. Siliceous outcrops are readily separable in the TIMS image from other types of host rocks. Different forms of silicification are not readily separable, yet, due to limitations of spatial resolution and spectral dynamic range. Features associated with the disseminated gold deposits, such as the large intrusive bodies and fault structures, are also resolvable on TIMS data. Inclusion of high-resolution thermal inertia data would be a useful supplement to the TIMS data.

Traditional Indian medicine (TIM) and traditional Korean medicine (TKM): aconstitutional-based concept and comparison.

Science.gov (United States)

Kang, Young Min; Komakech, Richard; Karigar, Chandrakant Shivappa; Saqib, Asma

2017-06-01

Traditional and complementary medicine (T&CM) plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM) and traditional Korean medicine (TKM) basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization reports. Despite the fact that TIM and TKM have individual qualities that are unique from each other including different histories of origin, they share a lot in common. Apart from Homeopathy in TIM, both systems are hinged on similar principle of body constitutional-based concept and similar disease diagnosis methods of mainly auscultation, palpation, visual inspection, and interrogation. Similarly, the treatment methods of TIM and TKM follow similar patterns involving use of medicinal herbs, moxibustion, acupuncture, cupping, and manual therapy. Both T&CM are majorly practiced in well-established hospitals by T&CM doctors who have undergone an average of 6-7 years of specialized trainings. However, unlike TIM which has less insurance coverage, the popularity of TKM is majorly due to its wide national insurance coverage. These two medical traditions occupy increasingly greater portion of the global market. However, TIM especially Ayurveda has gained more global recognition than TKM although the emergence of Sasang Constitutional Medicine in TKM is beginning to become more popular. This comparative analysis between TIM and TKM may provide vital and insightful contribution towards constitutional-based concept for further development and future studies in T&CM.

Meet EPA Scientist Tim Shafer, Ph.D.

Science.gov (United States)

Tim Shafer earned his bachelor’s degree in biology and chemistry from Hope College in Holland, MI, in 1986 and his Ph.D. in pharmacology and environmental toxicology from Michigan State University in 1991.

Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

Energy Technology Data Exchange (ETDEWEB)

Cai, X.Z. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang (China); Huang, W.Y.; Qiao, Y.; Chen, Y.; Du, S.Y.; Chen, D.; Yu, S. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Liu, N. [Department of Nephrology, First Affiliated Hospital, China Medical University, Shenyang (China); Dou, L.Y. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Jiang, Y. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang (China); Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang (China)

2014-10-17

The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P<0.001). No significant differences in TIM family protein expression were observed in leukocytes from SLE patients and healthy controls (P>0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (r{sub s}=0.283, P=0.049) and serum albumin (r{sub s}=0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; r{sub s}=-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE.

Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

International Nuclear Information System (INIS)

Cai, X.Z.; Huang, W.Y.; Qiao, Y.; Chen, Y.; Du, S.Y.; Chen, D.; Yu, S.; Liu, N.; Dou, L.Y.; Jiang, Y.

2014-01-01

The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P<0.001). No significant differences in TIM family protein expression were observed in leukocytes from SLE patients and healthy controls (P>0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (r s =0.283, P=0.049) and serum albumin (r s =0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; r s =-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE

Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.

Science.gov (United States)

Du, Xianhong; Wu, Zhuanchang; Xu, Yong; Liu, Yuan; Liu, Wen; Wang, Tixiao; Li, Chunyang; Zhang, Cuijuan; Yi, Fan; Gao, Lifen; Liang, Xiaohong; Ma, Chunhong

2018-05-07

As an immune checkpoint, Tim-3 plays roles in the regulation of both adaptive and innate immune cells including macrophages and is greatly involved in chronic liver diseases. However, the precise roles of Tim-3 in nonalcoholic steatohepatitis (NASH) remain unstated. In the current study, we analyzed Tim-3 expression on different subpopulations of liver macrophages and further investigated the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice. The results of flow cytometry demonstrated the significantly increased expression of Tim-3 on all detected liver macrophage subsets in MCD mice, including F4/80 + CD11b + , F4/80 + CD68 + , and F4/80 + CD169 + macrophages. Remarkably, Tim-3 knockout (KO) significantly accelerated MCD-induced liver steatosis, displaying higher serum ALT, larger hepatic vacuolation, more liver lipid deposition, and more severe liver fibrosis. Moreover, compared with wild-type C57BL/6 mice, Tim-3 KO MCD mice demonstrated an enhanced expression of NOX2, NLRP3, and caspase-1 p20 together with increased generation of IL-1β and IL-18 in livers. In vitro studies demonstrated that Tim-3 negatively regulated the production of reactive oxygen species (ROS) and related downstream pro-inflammatory cytokine secretion of IL-1β and IL-18 in macrophages. Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD. In conclusion, Tim-3 is a promising protector in MCD-induced steatohepatitis by controlling ROS and the associated pro-inflammatory cytokine production in macrophages.

Traditional Indian medicine (TIM and traditional Korean medicine (TKM: aconstitutional-based concept and comparison

Directory of Open Access Journals (Sweden)

Young Min Kang

2017-06-01

Full Text Available Traditional and complementary medicine (T&CM plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM and traditional Korean medicine (TKM basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization reports. Despite the fact that TIM and TKM have individual qualities that are unique from each other including different histories of origin, they share a lot in common. Apart from Homeopathy in TIM, both systems are hinged on similar principle of body constitutional-based concept and similar disease diagnosis methods of mainly auscultation, palpation, visual inspection, and interrogation. Similarly, the treatment methods of TIM and TKM follow similar patterns involving use of medicinal herbs, moxibustion, acupuncture, cupping, and manual therapy. Both T&CM are majorly practiced in well-established hospitals by T&CM doctors who have undergone an average of 6–7 years of specialized trainings. However, unlike TIM which has less insurance coverage, the popularity of TKM is majorly due to its wide national insurance coverage. These two medical traditions occupy increasingly greater portion of the global market. However, TIM especially Ayurveda has gained more global recognition than TKM although the emergence of Sasang Constitutional Medicine in TKM is beginning to become more popular. This comparative analysis between TIM and TKM may provide vital and insightful contribution towards constitutional-based concept for further development and future studies in T&CM.

Thermal ionisation mass spectrometry (TIMS): what, how and why?

International Nuclear Information System (INIS)

Aggarwal, S.K.

2002-01-01

Thermal ionisation mass spectrometry (TIMS) is one of the oldest mass spectrometric techniques, which has been used for determining the isotopic composition and concentration of different elements using isotope dilution. In spite of the introduction of many other inorganic mass spectrometric techniques like spark source mass spectrometry (SSMS), glow discharge mass spectrometry (GDMS), inductively coupled plasma-mass spectrometry (ICP-MS), secondary ion mass spectrometry (SIMS), the TIMS technique plays the role of a definitive analytical methodology and still occupies a unique position in terms of its capabilities with respect to precision and accuracy as well as sensitivity

Isotopic Ratios of Samarium by TIMS for Nuclear Forensic Application

Energy Technology Data Exchange (ETDEWEB)

Louis Jean, James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Inglis, Jeremy David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-08-08

The isotopic ratio of Nd, Sm, and Gd can provide important information regarding fissile material (nuclear devices, reactors), neutron environment, and device yield. These studies require precise measurement of Sm isotope ratios, by either TIMS or MC-ICP-MS. There has been an increasing trend to measure smaller and smaller quantities of Sm bearing samples. In nuclear forensics 10-100 ng of Sm are needed for precise measurement. To measure sub-ng Sm samples using TIMS for nuclear forensic analysis.

Novel effector phenotype of Tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients.

Science.gov (United States)

Liu, Zhuqing; McMichael, Elizabeth L; Shayan, Gulidanna; Li, Jing; Chen, Kevin; Srivastava, Raghvendra M; Kane, Lawrence P; Lu, Binfeng; Ferris, Robert L

2018-04-30

Regulatory T (Treg) cells are important suppressive cells among tumor infiltrating lymphocytes (TIL). Treg express the well-known immune checkpoint receptor PD-1, which is reported to mark "exhausted" Treg with lower suppressive function. T cell immunoglobulin mucin (Tim)-3, a negative regulator of Th1 immunity, is expressed by a sizeable fraction of TIL Tregs, but the functional status of Tim-3+ Tregs remains unclear. CD4+CTLA-4+CD25high Treg were sorted from freshly excised head and neck squamous cell carcinoma (HNSCC) TIL based on Tim-3 expression. Functional and phenotypic features of these Tim-3+ and Tim-3- TIL Tregs were tested by in vitro suppression assays and multi-color flow cytometry. Gene expression profiling and NanoString analysis of Tim-3+ TIL Treg were performed. A murine HNSCC tumor model was used to test the effect of anti-PD-1 immunotherapy on Tim-3+ Treg.  Results: Despite high PD-1 expression, Tim-3+ TIL Treg displayed a greater capacity to inhibit naïve T cell proliferation than Tim-3- Treg. Tim-3+ Treg from human HNSCC TIL also displayed an effector-like phenotype, with more robust expression of CTLA-4, PD-1, CD39 and IFN-γ receptor. Exogenous IFN-γ treatment could partially reverse the suppressive function of Tim-3+ TIL Treg. Anti-PD-1 immunotherapy downregulated Tim-3 expression on Tregs isolated from murine HNSCC tumors, and this treatment reversed the suppressive function of HNSCC TIL Tregs. Tim-3+ Treg are functionally and phenotypically distinct in HNSCC TIL, and are highly effective at inhibiting T cell proliferation despite high PD-1 expression.  IFN-γ induced by anti-PD-1 immunotherapy may be beneficial by reversing Tim-3+ Treg suppression. Copyright ©2018, American Association for Cancer Research.

Tim Berners-Lee, World Wide Web inventor

CERN Multimedia

1998-01-01

The "Internet, Web, What's next?" conference on 26 June 1998 at CERN: Tim Berners-Lee, inventor of the World Wide Web and Director of the W3C, explains how the Web came to be and gave his views on the future.

Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS

Science.gov (United States)

Garabedian, Alyssa; Benigni, Paolo; Ramirez, Cesar E.; Baker, Erin S.; Liu, Tao; Smith, Richard D.; Fernandez-Lima, Francisco

2017-09-01

In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150-250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMS-CID-TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow. The TIMS-TOF MS analysis permitted peptide biomarker detection based on accurate mobility, mass measurements, and high sequence coverage for concentrations in the 10-200 nM range, while simultaneously achieving discovery measurements of not initially targeted peptides as markers from the same proteins and, eventually, other proteins. [Figure not available: see fulltext.

PENGARUH BRAND IMAGE DAN BRAND AWARENESS TERHADAP MINAT PEMBELIAN SMARTPHONE APPLE IPHONE (Studi pada Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Hasanuddin)

OpenAIRE

-, ANDI FACHRUL DESTAMA

2017-01-01

ABSTRAK PENGARUH BRAND IMAGE DAN BRAND AWARENESS TERHADAP MINAT PEMBELIAN SMARTPHONE APPLE IPHONE (Studi pada Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Hasanuddin) THE INFLUENCE OF BRAND IMAGE AND BRAND AWARENESS TO THE PURCHASE INTENTION OF APPLE IPHONE SMARTPHONE (Study on Students of Economic and Business Faculty, Hasanuddin University) Andi Fachrul Destama Muh. Asdar Abdul Razak Munir Penelitian ini bertujuan untuk mengetahui sejauh mana pengaruh Bran...

TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity

Science.gov (United States)

Angiari, Stefano; Donnarumma, Tiziano; Rossi, Barbara; Dusi, Silvia; Pietronigro, Enrica; Zenaro, Elena; Della Bianca, Vittorina; Toffali, Lara; Piacentino, Gennj; Budui, Simona; Rennert, Paul; Xiao, Sheng; Laudanna, Carlo; Casasnovas, Jose M.; Kuchroo, Vijay K.; Constantin, Gabriela

2014-01-01

SUMMARY Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper-1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 IgV domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease. PMID:24703780

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

Science.gov (United States)

Nozaki, Yuji; Nikolic-Paterson, David J; Snelgrove, Sarah L; Akiba, Hisaya; Yagita, Hideo; Holdsworth, Stephen R; Kitching, A Richard

2012-05-01

The T-cell immunoglobulin mucin 1 (Tim-1) modulates CD4(+) T-cell responses and is also expressed by damaged proximal tubules in the kidney where it is known as kidney injury molecule-1 (Kim-1). We sought to define the role of endogenous Tim-1 in experimental T-cell-mediated glomerulonephritis induced by sheep anti-mouse glomerular basement membrane globulin acting as a planted foreign antigen. Tim-1 is expressed by infiltrating activated CD4(+) cells in this model, and we studied the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) on immune responses and glomerular disease. Crescentic glomerulonephritis, proliferative injury, and leukocyte accumulation were attenuated following treatment with anti-Tim-1 antibodies, but interstitial foxp3(+) cell accumulation and interleukin-10 mRNA were increased. T-cell proliferation and apoptosis decreased in the immune system along with a selective reduction in Th1 and Th17 cellular responses both in the immune system and within the kidney. The urinary excretion and renal expression of Kim-1 was reduced by anti-Tim-1 antibodies reflecting diminished interstitial injury. The effects of anti-Tim-1 antibodies were not apparent in the early phase of renal injury, when the immune response to sheep globulin was developing. Thus, endogenous Tim-1 promotes Th1 and Th17 nephritogenic immune responses and its neutralization reduces renal injury while limiting inflammation in cell-mediated glomerulonephritis.

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry.

Science.gov (United States)

Rhein, Bethany A; Brouillette, Rachel B; Schaack, Grace A; Chiorini, John A; Maury, Wendy

2016-07-01

Phosphatidylserine (PtdSer) receptors that are responsible for the clearance of dying cells have recently been found to mediate enveloped virus entry. Ebola virus (EBOV), a member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells. The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved PtdSer binding pocket within the amino-terminal IgV domain. While the residues within the TIM-1 IgV domain that are important for EBOV entry are characterized, the molecular details of virion-TIM-4 interactions have yet to be investigated. As sequences and structural alignments of the TIM proteins suggest distinct differences in the TIM-1 and TIM-4 IgV domain structures, we sought to characterize TIM-4 IgV domain residues required for EBOV entry. Using vesicular stomatitis virus pseudovirions bearing EBOV glycoprotein (EBOV GP/VSVΔG), we evaluated virus binding and entry into cells expressing TIM-4 molecules mutated within the IgV domain, allowing us to identify residues important for entry. Similar to TIM-1, residues in the PtdSer binding pocket of murine and human TIM-4 (mTIM-4 and hTIM-4) were found to be important for EBOV entry. However, additional TIM-4-specific residues were also found to impact EBOV entry, with a total of 8 mTIM-4 and 14 hTIM-4 IgV domain residues being critical for virion binding and internalization. Together, these findings provide a greater understanding of the interaction of TIM-4 with EBOV virions. With more than 28,000 cases and over 11,000 deaths during the largest and most recent Ebola virus (EBOV) outbreak, there has been increased emphasis on the development of therapeutics against filoviruses. Many therapies under investigation target EBOV cell entry. T-cell immunoglobulin mucin (TIM) domain proteins are cell surface factors important for the entry of many enveloped viruses

Economist Innovation Award for Tim Berners-Lee

CERN Multimedia

2003-01-01

In September, Tim Berners-Lee, who invented the World Wide Web at CERN and is now Director of the W3C World Wide Web Consortium, received the 2nd Economist Annual Innovation Award in Computing. With the award The Economist, a British weekly newspaper, recognises individuals responsible for breakthroughs in Bioscience, Computing, Energy and the Environment, and Telecommunications that have a profound impact on industry. A fifth award is given in a special "No Boundaries" category, observing innovation that transcends industries. Candidates for the awards are proposed by The Economist readers and writers, and by a group of judges. Tim Berners-Lee received the Computing award for his global hypertext project, to be known as the World Wide Web, which "forever altered the way information is shared" and is a huge contribution to the efficiency of the scientific community. Based on a programme for storing information using random associations called "Enquire", it...

PEMBUATAN MODEL PROFIL MAHASISWA FAKULTAS TEKNIK UNIVERSITAS PANCASILA

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Paryudi Paryudi

2009-01-01

Full Text Available Promotion is a must for a university to get students. With the innocence of the promotion team about the existing student profile, it will cause the team does not know which segment should be the promotion target. The consequence is that the promotion cost will be higher. In order to have a better promotion, we can use direct marketing method. In this method, a profile model of the existing students must be first created. With this profile model, promotion team can focus the promotion only to candidate student match with the model. The advantages of this method are: promotion cost can be reduced, response rate increase, and profit also increase. In order to create a model in direct marketing, we need previous promotion data. Since previous promotion data is not available, two methods in creating preliminary models are proposed. Next, the preliminary models will be tested using data mining software available in the market. Model with minimal accuracy of 75% will be chosen. If there are more than one model with minimal accuracy of 75%, then model with the highest accuracy will be chosen. Abstract in Bahasa Indonesia: Promosi merupakan suatu keharusan bagi sebuah universitas untuk mendapatkan mahasiswa. Dengan masih awamnya tim promosi terhadap profil mahasiswa yang sudah ada, maka tim promosi melakukan promosi tanpa melihat segmen pasar yang harus dituju. Konsekuensinya adalah biaya promosi menjadi lebih mahal. Untuk melakukan promosi dengan lebih baik, dapat menggunakan metode direct marketing. Pada metode ini, model profil dari mahasiswa yang sudah ada harus dibuat terlebih dulu. Dengan menggunakan model profil ini, tim promosi dapat memfokuskan promosi hanya pada calon-calon mahasiswa yang sesuai dengan model. Keuntungan dari metode promosi ini adalah biaya promosi dapat dikurangi, tingkat respon meningkat, dan keuntungan juga meningkat. Untuk membuat model pada direct marketing dibutuhkan data dari promosi sebelumnya. Karena data promosi

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria.

Science.gov (United States)

Popov-Celeketić, Dusan; Mapa, Koyeli; Neupert, Walter; Mokranjac, Dejana

2008-05-21

The TIM23 (translocase of the mitochondrial inner membrane) complex mediates translocation of preproteins across and their insertion into the mitochondrial inner membrane. How the translocase mediates sorting of preproteins into the two different subcompartments is poorly understood. In particular, it is not clear whether association of two operationally defined parts of the translocase, the membrane-integrated part and the import motor, depends on the activity state of the translocase. We established conditions to in vivo trap the TIM23 complex in different translocation modes. Membrane-integrated part of the complex and import motor were always found in one complex irrespective of whether an arrested preprotein was present or not. Instead, we detected different conformations of the complex in response to the presence and, importantly, the type of preprotein being translocated. Two non-essential subunits of the complex, Tim21 and Pam17, modulate its activity in an antagonistic manner. Our data demonstrate that the TIM23 complex acts as a single structural and functional entity that is actively remodelled to sort preproteins into different mitochondrial subcompartments.

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.

Directory of Open Access Journals (Sweden)

Brian Tomkowicz

Full Text Available TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3 is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells. Recent studies indicate that TIM-3 serves as a negative regulator of T cell function (i.e. T cell dependent immune responses, proliferation, tolerance, and exhaustion. Despite having no recognizable inhibitory signaling motifs, the intracellular tail of TIM-3 is apparently indispensable for function. Specifically, the conserved residues Y265/Y272 and surrounding amino acids appear to be critical for function. Mechanistically, several studies suggest that TIM-3 can associate with interleukin inducible T cell kinase (ITK, the Src kinases Fyn and Lck, and the p85 phosphatidylinositol 3-kinase (PI3K adaptor protein to positively or negatively regulate IL-2 production via NF-κB/NFAT signaling pathways. To begin to address this discrepancy, we examined the effect of TIM-3 in two model systems. First, we generated several Jurkat T cell lines stably expressing human TIM-3 or murine CD28-ECD/human TIM-3 intracellular tail chimeras and examined the effects that TIM-3 exerts on T cell Receptor (TCR-mediated activation, cytokine secretion, promoter activity, and protein kinase association. In this model, our results demonstrate that TIM-3 inhibits several TCR-mediated phenotypes: i NF-kB/NFAT activation, ii CD69 expression, and iii suppression of IL-2 secretion. To confirm our Jurkat cell observations we developed a primary human CD8+ cell system that expresses endogenous levels of TIM-3. Upon TCR ligation, we observed the loss of NFAT reporter activity and IL-2 secretion, and identified the association of Src kinase Lck, and PLC-γ with TIM-3. Taken together, our results support the conclusion that TIM-3 is a negative regulator of TCR-function by attenuating activation signals mediated by CD3/CD28 co-stimulation.

Tim de Zeeuw to Become the Next Director General of ESO

Science.gov (United States)

2007-01-01

The ESO Council has just appointed Tim de Zeeuw, 50, as the next Director General of ESO, effective as of 1 September 2007, when the current Director General, Catherine Cesarsky will complete her mandate. ESO PR Photo 02/07 ESO PR Photo 03/07 Professor Tim de Zeeuw "ESO is Europe's flagship organisation for ground-based astronomy," said, Richard Wade, President of the ESO Council. "The ESO Council is very pleased that Professor de Zeeuw has accepted the task as its next Director General. He has played a key role over the last few years in developing a strategic vision for ESO, and I have every confidence that he will now lead the organisation in the realisation of that exciting vision." Tim de Zeeuw has an excellent record, both as a highly respected scientist and as a leader of an internationally recognised science institute in the Netherlands. He is Scientific Director of the Leiden Observatory, a research institute in the College of Mathematics and Natural Sciences of Leiden University. Tim de Zeeuw also has considerable experience as regards science policy issues. Catherine Cesarsky, ESO's current Director General commented: "Over the recent years, ESO has developed considerably with more activities and new member states, and with its ambitious project portfolio, ESO is clearly facing an exciting future. I shall be delighted to pass the baton to Tim de Zeeuw, who as a recent Council member is very familiar with our Organisation." "It is a great honour and an exciting challenge to lead this world-class organisation in the years to come in support of one of the most dynamic areas of science today," said de Zeeuw. "I look forward to overseeing the continued upgrading of the Very Large Telescope with the second-generation instrumentation and the completion of the ALMA project, and in particular to help developing the future European Extremely Large Telescope." Tim de Zeeuw's main research interests embrace the formation, structure and dynamics of galaxies

El De imaginibus caelestibus de Ibn al-Ḥātim

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Oliveras, Marc

2009-06-01

Full Text Available K. Lippincott and D. Pingree published in 1987 a first Latin edition and English translation of the 15^th bilingual Arabic-Latin De imaginibus caelestibus, written originally by the Andalusian Ibn al-Ḥātim in the 10th century. The paper presented here aims to complete the preceding one with an Arabic edition, Spanish translation and some interpretations on the possible sources of talismanic imagery. In this brief astromagic treatise, Ibn al-Ḥātim focuses on twenty eight talismans, related to the lunar mansions, and their magical properties.

En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥātim se dedica principalmente a describir veintiocho talismanes, relacionados con las mansiones lunares, y sus propiedades mágicas.

T-bet-mediated Tim-3 expression dampens monocyte function during chronic hepatitis C virus infection.

Science.gov (United States)

Yi, Wenjing; Zhang, Peixin; Liang, Yan; Zhou, Yun; Shen, Huanjun; Fan, Chao; Moorman, Jonathan P; Yao, Zhi Q; Jia, Zhansheng; Zhang, Ying

2017-03-01

Hepatitis C virus (HCV) induces a high rate of chronic infection via dysregulation of host immunity. We have previously shown that T-cell immunoglobulin and mucin domain protein-3 (Tim-3) is up-regulated on monocyte/macrophages (M/Mφ) during chronic HCV infection; little is known, however, about the transcription factor that controls its expression in these cells. In this study, we investigated the role of transcription factor, T-box expressed in T cells (T-bet), in Tim-3 expression in M/Mφ in the setting of HCV infection. We demonstrate that T-bet is constitutively expressed in resting CD14 + M/Mφ in the peripheral blood. M/Mφ from chronically HCV-infected individuals exhibit a significant increase in T-bet expression that positively correlates with an increased level of Tim-3 expression. Up-regulation of T-bet is also observed in CD14 + M/Mφ incubated with HCV + Huh7.5 cells, as well as in primary M/Mφ or monocytic THP-1 cells exposed to HCV core protein in vitro, which is reversible by blocking HCV core/gC1qR interactions. Moreover, the HCV core-induced up-regulation of T-bet and Tim-3 expression in M/Mφ can be abrogated by incubating the cells with SP600125 - an inhibitor for the c-Jun N-terminal kinase (JNK) signalling pathway. Importantly, silencing T-bet gene expression decreases Tim-3 expression and enhances interleukin-12 secretion as well as signal transducer and activator of transcription 1 phosphorylation. These data suggest that T-bet, induced by the HCV core/gC1qR interaction, enhances Tim-3 expression via the JNK pathway, leading to dampened M/Mφ function during HCV infection. These findings reveal a novel mechanism for Tim-3 regulation via T-bet during HCV infection, providing new targets to combat this global epidemic viral disease. © 2016 John Wiley & Sons Ltd.

TIM1 (HAVCR1 Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

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Anshuman Das

2017-09-01

Full Text Available Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1 is widely accepted to be the receptor for hepatitis A virus (HAV, an unusual, hepatotropic human picornavirus. However, its identification as the hepatovirus receptor predated the discovery that hepatoviruses undergo nonlytic release from infected cells as membrane-cloaked, quasi-enveloped HAV (eHAV virions that enter cells via a pathway distinct from naked, nonenveloped virions. We thus revisited the role of TIM1 in hepatovirus entry, examining both adherence and infection/replication in cells with clustered regularly interspaced short palindromic repeat (CRISPR/Cas9-engineered TIM1 knockout. Cell culture-derived, gradient-purified eHAV bound Huh-7.5 human hepatoma cells less efficiently than naked HAV at 4°C, but eliminating TIM1 expression caused no difference in adherence of either form of HAV, nor any impact on infection and replication in these cells. In contrast, TIM1-deficient Vero cells showed a modest reduction in quasi-enveloped eHAV (but not naked HAV attachment and replication. Thus, TIM1 facilitates quasi-enveloped eHAV entry in Vero cells, most likely by binding phosphatidylserine (PtdSer residues on the eHAV membrane. Both Tim1−/− Ifnar1−/− and Tim4−/− Ifnar1−/− double-knockout mice were susceptible to infection upon intravenous challenge with infected liver homogenate, with fecal HAV shedding and serum alanine aminotransferase (ALT elevations similar to those in Ifnar1−/− mice. However, intrahepatic HAV RNA and ALT elevations were modestly reduced in Tim1−/−Ifnar1−/− mice compared to Ifnar1−/− mice challenged with a lower titer of gradient-purified HAV or eHAV. We conclude that TIM1 is not an essential hepatovirus entry factor, although its PtdSer-binding activity may contribute to the spread of quasi-enveloped virus and liver injury in mice.

Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS

Energy Technology Data Exchange (ETDEWEB)

Garabedian, Alyssa; Benigni, Paolo; Ramirez, Cesar; Baker, Erin M.; Liu, Tao; Smith, Richard D.; Fernandez-Lima, Francisco

2018-05-01

Abstract. In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150–250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMSCID- TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow. The TIMS-TOF MS analysis permitted peptide biomarker detection based on accurate mobility, mass measurements, and high sequence coverage for concentrations in the 10–200 nM range, while simultaneously achieving discovery measurements

Heavy metal contamination in TIMS Branch sediments

International Nuclear Information System (INIS)

Pickett, J.B.

1990-01-01

The objective of this memorandum is to summarize results of previous sediment studies on Tims Branch and Steed's Pond conducted by Health Protection (HP) and by the Savannah River Laboratory (SRL) in conjunction with Reactor Materials Engineering ampersand Technology (RMET). The results for other heavy metals, such as lead, nickel, copper, mercury, chromium, cadmium, zinc, and thorium are also summarized

Sild humanitaar- ja loodusteaduste vahel : intervjuu Aberdeeni ülikooli sotsiaalantropoloogia professori Tim Ingoldiga / Tim Ingold ; interv. Alo Joosepson, Kaie Kotov, Silver Rattasepp, Riste Keskpaik

Index Scriptorium Estoniae

Ingold, Tim

2004-01-01

4. rahvusvahelise keskkonnaesteetika ja -semiootika konverentsi "Kultuur, loodus, semiootika: kohad" üks peaesineja Tim Ingold tegeleb 1990-ndatest alates antropoloogia ja kunsti suhte uurimisega ning loeb kursust "Antropoloogia, arheoloogia, kunst ja arhitektuur"

Tim Berners-Lee: inventor de la World Wide Web

OpenAIRE

Universidad de Granada. Biblioteca

2015-01-01

El presente Cat??logo contiene la exposici??n organizada por la Biblioteca de la ETSIIT de la Universidad de Granada durante los meses de noviembre-diciembre de 2015 y titulada: "Tim Berners-Lee: inventor de la World Wide Web"

REMASTERING LIVE USB UNTUK LAMP PADA FAKULTAS SAINS DAN TEKNOLOGI PALEMBANG

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Klaudius Jevanda B.S.

2015-11-01

Full Text Available ABSTRAK Penelitian ini bertujuan untuk membuat distribusi Linux bernama Lubuntu yang memfokuskan diri pada desktop yang ringan serta ditujukan untuk menjadi lingkungan web server yang free dalam bentuk live USB. Dimana, penelitian ini menjelaskan tentang desain dan implementasi dari distribusi Linux Lubuntu itu sendiri yang nantinya bisa terus diperbaiki, disempurnakan dan dimungkinkan untuk dimodifikasi serta dipelajari oleh pihak lain. Lubuntu dikembangkan dengan memodifikasi dari Linux Lubuntu 14.04 dari tahap penambahan program, penghapusan program dan konfigurasi sampai pada tahap pembuatan Live USB untuk LAMP (Linux Apache Mysql PHP menggunakan metode remastering. Hasil dari penelitian ini berupa Live USB yang berisi tool untuk lingkungan web server. Tool utama dalam Live USB diantaranya adalah phpmyadmin, gimp, inkscape, dan bluefish. Keluaran penelitian ini, diharapkan bisa digunakan sebagai sistem operasi dan dikhususkan dalam lingkungan web server yang nyaman untuk dipergunakan dalam proses belajar mengajar pada matakuliah sistem operasi, pemrograman basis web I, dan pemrograman basis web II di Fakultas Sains dan Teknologi Universitas Katolik Musi Charitas palembang. Kata kunci: linux, web server, LAMP, remastering, live usb.

Hubungan Aktivitas Fisik Harian dengan Gangguan Menstruasi pada Mahasiswa Fakultas Kedokteran Universitas Andalas

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Putri Anindita

2016-09-01

Full Text Available  AbstrakGangguan menstruasi dapat menimbulkan stres dan menurunkan kualitas hidup wanita. Gambaran menstruasi seseorang dapat memperlihatkan keadaan fungsi reproduksi seseorang dan risiko mengalami berbagai penyakit. Aktivitas fisik diperkirakan sebagai salah satu cara untuk mengurangi terjadinya gangguan menstruasi tersebut. Tujuan penelitian ini adalah menentukan hubungan antara aktivitas fisik harian dan gangguan menstruasi. Desain penelitian  menggunakan cross sectional study dengan jumlah subjek 90 mahasiswi Fakultas Kedokteran Universitas Andalas Angkatan 2011-2013. Data didapatkan dari kuisioner yang diisi langsung oleh masing-masing responden yang kemudian dianalisis denga uji chi-square. Hasil penelitian mendapatkan gangguan menstruasi terjadi pada 73,3% mahasiswi dengan gangguan yang paling sering terjadi yaitu dysmenorrhea sebanyak 63,3%. Sebagian besar mahasiswi tersebut memiliki aktivitas fisik harian yang cukup menurut rekomendasi WHO yaitu sebanyak 60%. Berdasarkan uji chi-square, tidak ditemukan adanya hubungan antara aktivitas fisik harian dan gangguan menstruasi (p= 0,846. Kesimpulan ialah tidak terdapat hubungan yang bermakna antara aktivitas fisik harian dan gangguan menstruasi pada mahasiswi Fakultas Kedokteran Universitas Andalas.Kata kunci: aktivitas fisik, gangguan menstruasi, mahasiswi FK AbstractMenstrual disorder is often cause stress and decrease the life quality of a woman. Menstrual pattern can describe the condition of reproduction function and risk of having several disease. Physical Activity is considered as one of the way to reduce menstrual disorder. The objective of this study was to determine the association between daily physical activity and menstrual disorder.This  study  used cross sectional design on 90 female medical student of Andalas University Class of 2011-2013 as the sample. The data from self reported questionnaire that was given to the students is analyzed using chi-square.The results show

Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins.

Science.gov (United States)

Romero-Romero, Sergio; Costas, Miguel; Rodríguez-Romero, Adela; Alejandro Fernández-Velasco, D

2015-08-28

Temperature is one of the main variables that modulate protein function and stability. Thermodynamic studies of oligomeric proteins, the dominant protein natural form, have been often hampered because irreversible aggregation and/or slow reactions are common. There are no reports on the reversible equilibrium thermal unfolding of proteins composed of (β/α)8 barrel subunits, albeit this "TIM barrel" topology is one of the most abundant and versatile in nature. We studied the eponymous TIM barrel, triosephosphate isomerase (TIM), belonging to five species of different bacterial taxa. All of them were found to be catalytically efficient dimers. The three-dimensional structure of four enzymes was solved at high/medium resolution. Irreversibility and kinetic control were observed in the thermal unfolding of two TIMs, while for the other three the thermal unfolding was found to follow a two-state equilibrium reversible process. Shifts in the global stability curves of these three proteins are related to the organismal temperature range of optimal growth and modulated by variations in maximum stability temperature and in the enthalpy change at that temperature. Reversibility appears to correlate with the low isoelectric point, the absence of a residual structure in the unfolded state, small cavity volume in the native state, low conformational stability and a low melting temperature. Furthermore, the strong coupling between dimer dissociation and monomer unfolding may reduce aggregation and favour reversibility. It is therefore very thought-provoking to find that a common topological ensemble, such as the TIM barrel, can unfold/refold in the Anfinsen way, i.e. without the help of the cellular machinery.

Interaction between Galectin-9/TIM-3 pathway and follicular helper CD4+ T cells contributes to viral persistence in chronic hepatitis C.

Science.gov (United States)

Zhuo, Ya; Zhang, Yi-Fu; Wu, Hong-Jie; Qin, Lei; Wang, Yan-Ping; Liu, A-Min; Wang, Xin-Hong

2017-10-01

Both Galectin 9 (Gal-9)/T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) pathway and follicular helper CD4 + T (Tfh) cells play important roles in persistent hepatitis C virus (HCV) infection. Thus, we aimed to investigate the regulatory role of interaction between Gal-9/TIM-3 pathway and Tfh cells in chronic hepatitis C. A total of 44 chronic hepatitis C patients and 19 normal controls (NCs) were enrolled in this study. Purified CD4 + T cells were cultured by TIM-3 Fc protein, recombinant Gal-9, or IL-21 for 48h. TIM-3 expression, Tfh proportion, and IL-21 production was measured, respectively. The immunomodulatory role of Gal-9/TIM-3 and IL-21 was also investigated in HCV cell culture system in vitro. We found that the percentage corresponding to both TIM-3-positive and CXCR5 + ICOS + Tfh cells within CD4 + T cells, which correlated with HCV RNA replication, was significantly elevated in patients with chronic hepatitis C in comparison with those in NCs. Moreover, blockade of Gal-9/TIM-3 pathway by TIM-3 Fc protein increased Tfh cells proportion, IL-21 mRNA and protein expression within purified CD4 + T cells, while activation of Gal-9/TIM-3 signaling by Gal-9 stimulation decreased IL-21 production in both patients with chronic HCV infection and healthy individuals. Meanwhile, high concentrations (100 and 200ng/mL) of IL-21 stimulation also elevated TIM-3 expression on CD4 + T cells in chronic hepatitis C. Furthermore, TIM-3 blockage and IL-21 stimulation suppressed mRNA expressions of HCV-induced antiviral proteins (myxovirus resistance A and oligoadenylate synthetase) in Huh7.5 cells without affecting viral replication in HCV cell culture system. The interaction between Gal-9/TIM-3 pathway and Tfh cells contributed to viral persistent in chronic HCV infection, which might be pivotal for development of new therapeutic approaches for chronic hepatitis C. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Upregulation of Tim-3 on CD4(+) T cells is associated with Th1/Th2 imbalance in patients with allergic asthma.

Science.gov (United States)

Tang, Fei; Wang, Fukun; An, Liyun; Wang, Xianling

2015-01-01

T cell Ig and mucin domain-containing molecule-3 (Tim-3) is a negative regulator preferentially expressed on Th1 cells. Allergic asthma is a clinical syndrome well characterized by Th1/Th2 imbalance. To investigate the role of Tim-3 in the pathogenesis of asthma and its relationship with Th1/Th2 imbalance, a total of 40 patients with allergic asthma and 40 healthy controls were enrolled. Expression of Tim-3 and Th1/Th2 imbalance as well as the relationship between them was analyzed by flow cytometry and real-time PCR. Peripheral blood mononuclear cells (PBMCs) were cultured in vitro and anti-Tim-3 was used to block Tim-3 signaling; Th1/Th2 cytokines in the culture supernatant were detected by enzyme linked immunosorbent assay (ELISA). CD4(+) T cells and B cells were sorted and co-cultured in vitro, and anti-Tim-3 was used to block Tim-3 signaling; Total IgG/IgE in the culture supernatant was detected by ELISA. The mRNA level of T-bet and IFN-γ were significantly decreased in allergic asthma patients, while GATA-3 and IL-4 were significantly increased. Expression of Tim-3 on CD4(+) T cells was much higher in allergic asthma patients and it was negatively correlated with T-bet/GATA-3 ratio or IFN-γ/IL-4 ratio. Blocking of Tim-3 significantly increased Th1 cytokines (TNF-α and IFN-γ) and decreased Th2 cytokines (IL-4, IL-5, IL-13) in the culture supernatant of PBMCs. Blocking of Tim-3 dramatically reduced the production of IgG and IgE in the co-culture supernatant of CD4(+) T cells and B cells. In conclusion, Tim-3 was up-regulated in allergic asthma patients and related with the Th1/Th2 imbalance. Blocking of Tim-3 may be of therapeutic benefit by enhancing the Th1 cytokines response, down-regulating the Th2 cytokines response, and reducing IgG/IgE production.

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions.

Science.gov (United States)

Das, Anshuman; Hirai-Yuki, Asuka; González-López, Olga; Rhein, Bethany; Moller-Tank, Sven; Brouillette, Rachel; Hensley, Lucinda; Misumi, Ichiro; Lovell, William; Cullen, John M; Whitmire, Jason K; Maury, Wendy; Lemon, Stanley M

2017-09-05

Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. However, its identification as the hepatovirus receptor predated the discovery that hepatoviruses undergo nonlytic release from infected cells as membrane-cloaked, quasi-enveloped HAV (eHAV) virions that enter cells via a pathway distinct from naked, nonenveloped virions. We thus revisited the role of TIM1 in hepatovirus entry, examining both adherence and infection/replication in cells with clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-engineered TIM1 knockout. Cell culture-derived, gradient-purified eHAV bound Huh-7.5 human hepatoma cells less efficiently than naked HAV at 4°C, but eliminating TIM1 expression caused no difference in adherence of either form of HAV, nor any impact on infection and replication in these cells. In contrast, TIM1-deficient Vero cells showed a modest reduction in quasi-enveloped eHAV (but not naked HAV) attachment and replication. Thus, TIM1 facilitates quasi-enveloped eHAV entry in Vero cells, most likely by binding phosphatidylserine (PtdSer) residues on the eHAV membrane. Both Tim1 -/- Ifnar1 -/- and Tim4 -/- Ifnar1 -/- double-knockout mice were susceptible to infection upon intravenous challenge with infected liver homogenate, with fecal HAV shedding and serum alanine aminotransferase (ALT) elevations similar to those in Ifnar1 -/- mice. However, intrahepatic HAV RNA and ALT elevations were modestly reduced in Tim1 -/- Ifnar1 -/- mice compared to Ifnar1 -/- mice challenged with a lower titer of gradient-purified HAV or eHAV. We conclude that TIM1 is not an essential hepatovirus entry factor, although its PtdSer-binding activity may contribute to the spread of quasi-enveloped virus and liver injury in mice. IMPORTANCE T cell immunoglobulin and mucin-containing domain protein 1 (TIM1) was reported more than

Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease.

Science.gov (United States)

Tang, Zhao-Hui; Liang, Shuwen; Potter, James; Jiang, Xuan; Mao, Hai-Quan; Li, Zhiping

2013-02-15

T cell Ig and mucin domain (Tim)-3 is well known to interact with its natural ligand, Galectin-9 (Gal-9), to regulate T cell function. However, little is known about the function of Tim-3/Gal-9 signaling in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) mediated by hepatic NKT cells that also express Tim-3. In the current study, we define the role and the mechanism of Tim-3/Gal-9 signaling in hepatic NKT cell regulation in a mouse model of diet-induced NAFLD. Adult male wild-type or CD1d knockout C57BL/6 mice were fed a high-fat diet to induce steatosis. Some of the mice also received one or a combination of Gal-9, anti-IL-15R/IL-15 mAb, rIL-15, α-galactosylceramide, and multilamellar liposomes containing Cl(2)MDP. The expression of Tim-3 and various markers reflecting cell proliferation, activation, cytokine production, and apoptosis was analyzed. Liver histology, steatosis grade, and hepatic triglyceride content were also evaluated. In the liver, Tim-3(+) NKT cells are in an activated state, and Gal-9 directly induces Tim-3(+) NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. However, Gal-9 also interacts with Tim-3-expressing Kupffer cells to induce secretion of IL-15, thus promoting NKT cell proliferation. Exogenous administration of Gal-9 significantly ameliorates diet-induced steatosis by modulating hepatic NKT cell function. In summary, the Tim-3/Gal-9-signaling pathway plays a critical role in the homeostasis of hepatic NKT cells through activation-induced apoptosis and secondary proliferation and, thus, contributes to the pathogenesis of NAFLD.

Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease

Science.gov (United States)

Liang, Shuwen; Potter, James; Jiang, Xuan; Mao, Hai-Quan

2013-01-01

T cell Ig and mucin domain (Tim)-3 is well known to interact with its natural ligand, Galectin-9 (Gal-9), to regulate T cell function. However, little is known about the function of Tim-3/Gal-9 signaling in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) mediated by hepatic NKT cells that also express Tim-3. In the current study, we define the role and the mechanism of Tim-3/Gal-9 signaling in hepatic NKT cell regulation in a mouse model of diet-induced NAFLD. Adult male wild-type or CD1d knockout C57BL/6 mice were fed a high-fat diet to induce steatosis. Some of the mice also received one or a combination of Gal-9, anti–IL-15R/IL-15 mAb, rIL-15, α-galactosylceramide, and multilamellar liposomes containing Cl2MDP. The expression of Tim-3 and various markers reflecting cell proliferation, activation, cytokine production, and apoptosis was analyzed. Liver histology, steatosis grade, and hepatic triglyceride content were also evaluated. In the liver, Tim-3+ NKT cells are in an activated state, and Gal-9 directly induces Tim-3+ NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. However, Gal-9 also interacts with Tim-3–expressing Kupffer cells to induce secretion of IL-15, thus promoting NKT cell proliferation. Exogenous administration of Gal-9 significantly ameliorates diet-induced steatosis by modulating hepatic NKT cell function. In summary, the Tim-3/Gal-9–signaling pathway plays a critical role in the homeostasis of hepatic NKT cells through activation-induced apoptosis and secondary proliferation and, thus, contributes to the pathogenesis of NAFLD. PMID:23296703

Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim.

Science.gov (United States)

Zonato, Valeria; Vanin, Stefano; Costa, Rodolfo; Tauber, Eran; Kyriacou, Charalambos P

2018-02-01

The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may have originated in southeastern Italy. Flies characterized by the new allele show photoperiod-related phenotypes likely to be adaptive in seasonal environments. ls-tim may be spreading from its point of origin in Italy by directional selection, but there are alternative explanations for its observed clinal geographical distribution, including balancing selection and demography. From population analyses of ls-tim frequencies collected on the eastern side of the Iberian Peninsula, we show that ls-tim frequencies are inverted compared with those in Italy. This pattern is consistent with a scenario of directional selection rather than latitude-associated balancing selection. Neutrality tests further reveal the signature of directional selection at the ls-tim site, which is reduced a few kb pairs either side of ls-tim. A reanalysis of allele frequencies from a large number of microsatellite loci do not demonstrate any frequent ls-tim-like spatial patterns, so a general demographic effect or population expansion from southeastern Italy cannot readily explain current ls-tim frequencies. Finally, a revised estimate of the age of ls-tim allele using linkage disequilibrium and coalescent-based approaches reveals that it may be only 300 to 3000 years old, perhaps explaining why it has not yet gone to fixation. ls-tim thus provides a rare temporal snapshot of a new allele that has come under selection before it reaches equilibrium.

Earth-Mars Telecommunications and Information Management System (TIMS): Antenna Visibility Determination, Network Simulation, and Management Models

Science.gov (United States)

Odubiyi, Jide; Kocur, David; Pino, Nino; Chu, Don

1996-01-01

This report presents the results of our research on Earth-Mars Telecommunications and Information Management System (TIMS) network modeling and unattended network operations. The primary focus of our research is to investigate the feasibility of the TIMS architecture, which links the Earth-based Mars Operations Control Center, Science Data Processing Facility, Mars Network Management Center, and the Deep Space Network of antennae to the relay satellites and other communication network elements based in the Mars region. The investigation was enhanced by developing Build 3 of the TIMS network modeling and simulation model. The results of several 'what-if' scenarios are reported along with reports on upgraded antenna visibility determination software and unattended network management prototype.

FAKTOR FAKTOR YANG MEMPENGARUHI PERSEPSI MAHASISWA TENTANG MATA KULIAH KEWIRAUSAHAAN DI FAKULTAS ILMU ADMINISTRASI UNIVERSITAS LANCANG KUNING PEKANBARU

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Abdul Mirad

2016-09-01

Full Text Available Abstrak Penelitian ini dilaksanakan di Fakultas Ilmu Administrasi Universitas  Lancang Kuning Pekanbaru,Dengan jangka waktu Penelitian 3 (tiga   Bulan. Dimana populasi dan sampelnya berjumlah 42  orang terdiri dari mahasiswa semesterVII kelas pagi Fia Unilak.Teknik pengambilan sampel menggunakan teknik sensus. Jenis data yang diambil dalam penelitian ini meliputi data ,  pengalaman masa lalu,keyakinan,dan pengalaman orang lain Konsep teori yang digunakan menggunakan konsep Vincent Gaspers.  Analisis data dalam penelitian ini menggunakan analisis deskriptif kualitatif. Penelitian ini didanai oleh Fakultas Ilmu Administrasi dengan dana  serjumlah 3 (tiga Juta rupiahHasil penelitian tentang Persepsi Mahasiswa Tentang Mata Kuliah Kewirausahaan Di Fakultas Ilmu Administrasi Universitas Lancang Kuning Pekanbaru adalah Cukup Baik dengan tanggapan sebanyak 18 responden atau 41,67 % memberikan tanggapan Cukup Baik dimana indikator yang paling dominan adalah pengalaman masa lalu sebanyak tanggapan 19 responden atau 42,52 %  Saran dalam penelitian ini adalah Untuk menciptakan dan memberikan pandangan kepada responden yang merupakan kader-kader muda dalam berusaha untuk menjalankan bisnis wirausaha yang diinginkan mengingat ketatnya persaingan dunia kerja sehingga berwirausaha merupakan salah satunya jalan yang harus ditempuh.dan Kepada semua pihak agar dapat bekerja sama membentuk kader wirausaha yang handal di lingkungan Universitas Lancang Kuning Pekanbaru. Kata kunci :persepsi mahasiswa, kewirausahaan Abstract                 This research was held at the Faculty of Administrative Sciences Lancang Kuning Pekanbaru, with a period of study of 3 (three months. Where the population and the sample amounted to 42 people consisting of morning class students of semester VII Fia Unilak. The sampling technique are using census. Type of data that collected in this study includes data, past experiences, beliefs, and experiences of others

Blocking Tim-3 or/and PD-1 reverses dysfunction of tumor-infiltrating lymphocytes in HBV-related hepatocellular carcinoma.

Science.gov (United States)

Liu, Furong; Zeng, Gucheng; Zhou, Shaotang; He, Xiaoshun; Sun, Nianfeng; Zhu, Xiaofeng; Hu, Anbin

2018-03-22

The immunosuppression of tumor-infiltrating lymphocytes (TILs) is associated with rapid progression of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). T cell Ig- and mucin-domain-containing molecule-3 (Tim-3) and programmed cell death 1 (PD-1) are important inhibitory molecules expressed on the surface of T cells, but their roles in the function of TILs in HBV-HCC are poorly understood. We aimed to study the roles of these two markers in HBV-HCC. Ninety patients with pathologically confirmed HBV-associated HCC were enrolled in our study. Blood samples, paired fresh tumor tissues and adjacent tissues were collected, and isolating peripheral blood mononuclear cells, TILs and adjacent-infiltrating lymphocytes were isolated from these samples. The patients were followed-up to allow survival analysis. Tim-3 or/and PD-1 was up-regulated expressed on CD4 + and CD8 + TILs in HBV-HCC patients and a higher proportion of TILs expressed PD-1 alone. Tim-3 + and PD-1 + TILs greatly decreased secretion of IFN-γ and TNF-α. Expression of Tim-3 and PD-1 on TILs negatively correlated with disease-free survival of HCC patients. Direct blockade of Tim-3 and PD-1 in vitro significantly enhanced TILs proliferation and secretion of IFN-γ and TNF-α. Expression of Tim-3 and/or PD-1 on TILs impairs their function and correlates negatively with disease-free survival in HBV-HCC. Direct blockade of Tim-3 and PD-1 restores anti-tumor effects of TILs, which suggests a potential target for novel immunotherapy in HBV-HCC. Copyright © 2018 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

A quantitative analysis of TIMS data obtained on the Learjet 23 at various altitudes

Science.gov (United States)

Jaggi, S.

1992-01-01

A series of Thermal Infrared Multispectral Scanner (TIMS) data acquisition flights were conducted on the NASA Learjet 23 at different altitudes over a test site. The objective was to monitor the performance of the TIMS (its estimation of the brightness temperatures of the ground scene) with increasing altitude. The results do not show any significant correlation between the brightness temperatures and the altitude. The analysis indicates that the estimation of the temperatures is a function of the accuracy of the atmospheric correction used for each altitude.

Analysis of Eocene depositional environments - Preliminary TM and TIMS results, Wind River Basin, Wyoming

Science.gov (United States)

Stucky, Richard K.; Krishtalka, Leonard; Redline, Andrew D.; Lang, Harold R.

1987-01-01

Both Landsat TM and aircraft Thermal IR Multispectral Scanner (TIMS) data have been used to map the lithofacies of the Wind River Basin's Eocene physical and biological environments. Preliminary analyses of these data have furnished maps of a fault contact boundary and a complex network of fluvial ribbon channel sandstones. The synoptic view thereby emerging for Eocene fluvial facies clarifies the relationships of ribbon channel sandstones to fossil-bearing overbank/floodplain facies and certain peleosols. The utility of TM and TIMS data is thereby demonstrated.

Onsite: A Residency with Tim Rollins/KOS. A Photo Essay.

Science.gov (United States)

Placky, Robert

2000-01-01

Presents a photo essay that visually narrates the workshop that took place in State College, Pennsylvania, from October 19-24, 1998 bringing together middle and high school students with Tim Rollins, who is a conceptual artist and educator, and Kids of Survival (KOS). (CMK)

α-Lactose Improves the Survival of Septic Mice by Blockade of TIM-3 Signaling to Prevent NKT Cell Apoptosis and Attenuate Cytokine Storm.

Science.gov (United States)

Yao, Yao; Deng, Hai; Li, Pingfei; Zhang, Jian; Zhang, Junbo; Wang, Deping; Li, Songbo; Luo, Yixing; Wei, Zhengping; Bi, Guoyu; Yang, Xiang-Ping; Tang, Zhao-Hui

2017-03-01

Sepsis is the leading cause of death among critically ill patients and natural killer T (NKT) cell activation is essential to induce inflammatory cytokine cascade in sepsis. However, little is known about what regulates the NKT cell function during sepsis. Herein, we showed that T-cell immunoglobulin and mucin domain 3 (Tim-3) expression in NKT cells is elevated in experimental mice during sepsis. Tim-3 expression was positively correlated with NKT cell activation and apoptosis. In sepsis, interleukin (IL)-12 secreted by dendritic cell exposure to lipopolysaccharide increased the expression of Tim-3 in NKT cells. Administration of α-lactose to block Tim-3 signaling pathway significantly improved the survival of septic mice, concomitant with reduced IL-12 production by dendritic cells, reduced Tim-3 expression, prevented NKT cell apoptosis, and attenuated production of inflammatory cytokines. Collectively, Tim-3 signaling in NKT cells plays a critical role in the immunopathogenesis of sepsis. Thus, α-lactose could be a promising immunomodulatory agent in the treatment of sepsis.

PENGARUH KEBUTUHAN TERHADAP MOTIF PENGGUNAAN KARTU DEBET BANK CENTRAL ASIA (BCA DI KALANGAN MAHASISWA AKTIF FAKULTAS EKONOMI UNIVERSITAS KRISTEN PETRA SURABAYA

Directory of Open Access Journals (Sweden)

Hatane Semuel

2003-01-01

Full Text Available This research is conducted to the students of class 1999, 2000, and 2001 of Economics Faculty of Petra Christian University. This research focuses on cognitive and affective motive of those subjects in using BCA's debit card, assuming that consumers tend to use objective and subjective factors in considering to purchase certain product. The result of this research shows that achievement needs, power needs, and affiliation needs simultaneously influence the motive of the subjects in using BCA's debit card, in which 46% of the influence can be explained by the model. Achievement needs have more dominant influence compared to power needs. Besides that, education factor (study duration found to influence the cognitive motive, which is shown by the motive difference among class 1999, 2000, and 2001. Abstract in Bahasa Indonesia : Penelitian dilakukan terhadap mahasiswa Fakultas ekonomi Universitas Kristen PETRA Surabaya angkatan 1999, 2000, dan 2001. Fokus penelitian pada motif kognitif dan afektif dalam menggunakan produk kartu debet BCA, dengan asumsi bahwa konsumen dalam mempertimbangkan pembelian suatu produk lebih didasarkan pada faktor obyektif dan subyektif. Hasil penelitian mengungkapkan kebutuhan yang diukur melalui, achievement needs, power needs, affiliation needs ternyata secara serempak berpengaruh terhadap motif penggunaan kartu debet BCA di kalangan mahasiswa Fakultas Ekonomi Universitas Kristen PETRA Surabaya, dengan kemampuan 46% dapat dijelaskan dari dalam model. Achievement needs mempunyai pengaruh lebih dominan dibandingkan power needs. Selain itu faktor pendidikan (lama studi mempunyai dampak terhadap motif kognitif, hal ini terungkap dari adanya perbedaan motif tersebut pada angkatan 1999 dengan angkatan 2000 maupun angkatan 2001. Kata kunci: motif, achievement, power, needs.

Smart Mirrors for Photorefractive Control of Light with Tim Bunning, RX - Agile Filters Application

Science.gov (United States)

2016-11-08

AFRL-AFOSR-UK-TR-2017-0008 Smart Mirrors for photorefractive control of light with Tim Bunning, RX-- Agile filters application Luciano De Sio...DATE (DD-MM-YYYY)      10-02-2017 2. REPORT TYPE Final 3. DATES COVERED (From - To) 01 Feb 2014 to 31 Jan 2016 4. TITLE AND SUBTITLE Smart Mirrors for...photorefractive control of light with Tim Bunning, RX-- Agile filters application 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-14-1-0050 5c.  PROGRAM

Pemanfaatan Jurnal Elektronik oleh Mahasiswa Fakultas Kedokteran Universitas Hasanuddin

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Harisyah Harisyah

2015-06-01

Full Text Available Jurnal merupakan referensi yang paling sering digunakan sebagai dasar dalam melakukan penelitian di perguruan tinggi, karena materi-materi yang dipublikasikan merupakan materi terkini dan merupakan hasil temuan atau hasil penelitian. Pada saat sekarang ini, munculnya jurnal elektronik mengakibatkan perpustakaan lebih memilih untuk berlangganan jurnal elektronik dibanding dengan media cetak. Hal ini dikarenakan jurnal elektronik lebih mudah diakses dibandingkan dengan jurnal cetak. UPT Perpustakaan Universitas Hasanuddin merupakan salah satu perpustakaan perguruan tinggi yang melanggan jurnal elektronik. Akan tetapi, jurnal elektronik yang dilanggan oleh UPT Perpustakaan Universitas Hasanuddin belum dimanfaatkan secara merata oleh mahasiswa khususnya Mahasiswa Fakultas Kedokteran Universitas Hasanuddin. Mahasiswa tidak memanfaatkan jurnal elektronik tersebut bukan dikarenakan mereka tidak membutuhkan jurnal elektronik yang telah dilanggan. Akan tetapi, sebahagian besar dari mahasiswa  belum mengetahui adanya jurnal elektronik yang telah dilanggan oleh UPT Perpustakaan Universitas Hasanuddin. Abstract :  Journal is one of information forms. It is often used as a primary source to research, mostly in higher education. Journal, as many defined it, consists of contemporary thoughts and knowledge, and research findings as well. Nowadays, electronic journals are considered as the main option for many higher institutions to subscribe compared to its printed form. It is due to the easiness and accessable usage. UPT Perpustakaan Hasanuddin (Hasanuddin University Library is one of those academic libraries that has been subscribed electronic journals. Nevertheless, those electronic journals were lack of usage by degree medical students. The main reason was the lack of promotion or dissemination by the library.

KUALITAS JASA UNIT PELAKSANA TEKNIS PENGUJIAN SERTIFIKASI MUTU BARANG-LEMBAGA TEMBAKAU JEMBER

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Shinta Setiadevi

2015-03-01

Full Text Available This study aims to 1 analyze the methods and the customer satisfaction measurement results; 2 analyze the satisfaction of customer based on alternatives method by using Servqual approach and EPA; 3 Analyze the comparison between method and the customer satisfaction measurement results; 4 formulate recommendations for improvement of measurement methods and results of customer satisfaction in the Technical Implementation Unit Testing Certification-Institute for Product Quality Tobacco Jember. The processing of the data in this study was used the analysis of Service Quality (Servqual and Expectation-Performance Analysis (EPA. The results of this study including: 1 Attributes which are considered sufficient by the IKM UPT measurement result  are nine attributes: the effectiveness and efficiency of service, courtesy, friendliness, and obtain justice and other services; 2 Attribute selected as a top priority improvements based on EPA method is the availability of equipment and the latest technology; 3 Methods and results of measuring the level of customer satisfaction can be compared based on: the number of dimensions and attributes of service; outputs and implications of measurement methods; measurement results; 4 Recommendations for improvement, the management should renew equipment and the latest technology in testing and calibration laboratories, and increase equipment and the latest technology at the service of fumigation.Keywords: EPA, service quality, servqual, UPT PSMB-LT JemberABSTRAKPenelitian ini bertujuan 1 menganalisis metode dan hasil pengukuran indek kepuasan masyarakat; 2 menganalisis tingkat kepuasan pelanggan berdasarkan alternatif metode melalui pendekatan Servqual dan EPA; 3 menganalisis perbandingan antara metode dan hasil pengukuran kepuasan pelanggan; 4 merumuskan rekomendasi perbaikan metode dan hasil pengukuran kepuasan pelanggan pada Unit Pelaksana Teknis Pengujian Sertifikasi Mutu Barang-Lembaga Tembakau Jember. Pengolahan

Suppression of TIM-1 predicates clinical efficacy of sublingual immunotherapy for allergic rhinitis in children.

Science.gov (United States)

Lin, Zhibin; Zhou, Lifeng; Luo, Xi; Xia, Wentong; Chen, Dehua; Xu, Rui; Wang, Jie; Luo, Renzhong; Xu, Geng; Li, Huabin

2013-08-01

To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) with house-dust mite (HDM) extract and to examine the change of biomarkers (TIM-1, IL-5 and IL-10) after 6-month SLIT in children with allergic rhinitis (AR). One hundred and sixteen HDM-sensitized children with persistent AR were enrolled to assess the clinical efficacy of SLIT by determining the individual nasal symptom score (INSS) and total nasal symptom scores (TNSS) after 6-month SLIT. Moreover, the mRNA expression of TIM-1, IL-5 and IL-10 in peripheral blood mononuclear cells (PBMCs) was examined in 16 well-controlled and 12 uncontrolled AR patients using quantitative reverse transcription polymerase chain reaction (qRT-PCR). After 6-month SLIT, both TNSS and INSS scores were significantly decreased compared with the baseline value (p < 0.01). The rates for well-controlled, partly controlled and uncontrolled children were 43.1%, 32.8% and 24.1%, respectively. Accordingly, the mRNA levels of TIM-1 and IL-5 decreased significantly and IL-10 mRNA level increased significantly compared with the baseline value in well-controlled children (p < 0.05). Our findings suggest SLIT with HDM extract is effective and safe for AR children and TIM-1 may be considered as an indicator for evaluating the clinical efficacy of SLIT. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Individualized Education Program (IEP Mata Pelajaran Kimia untuk Siswa Slow Learner

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Rovik Rovik

2017-06-01

[Siswa slow learner menempati populasi tertinggi untuk siswa berkebutuhan khusus. Sebagai salah satu jenis learning disability, slow learner masih dapat belajar dengan teman sebayanya asalkan guru mempersiapkan program pembelajaran khusus yang telah dimodifikasi dari pembelajaran reguler. Program ini disebut Individualized Education Program (IEP. Penelitian ini mencoba mengembangkan IEP mata pelajaran kimia untuk slow learner, mengidentifikasi komponen yang dibutuhkan dalam menyusun IEP untuk slow learner, dan menganalisis judgement reviewers (guru kimia dan guru pendamping khusus dan peer reviewers terhadap IEP yang dikembangkan. Hasil penelitian menunjukkan slow learner membutuhkan IEP sebagai dokumen utama panduan guru dalam pembelajaran kimia di kelas. Komponen pengembangan IEP meliputi identitas peserta didik, tim pengembangan dan pelaksana, asesmen yang pernah dilakukan, hambatan dan kekuatan, kebutuhan dan perlakuan, faktor pendukung dan penghambat, rencana perlakuan, dan modifikasi terhadap perangkat pembelajaran kimia reguler

HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

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Lishomwa C Ndhlovu

2011-04-01

Full Text Available The T cell immunoglobulin mucin 3 (Tim-3 receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurological complex and its classic neurological presentation called HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis, we investigated the expression of the Tim-3 receptor on CD8(+ T cells from a cohort of HTLV-1 seropositive asymptomatic and symptomatic patients. Patients diagnosed with HAM/TSP down-regulated Tim-3 expression on both CD8(+ and CD4(+ T cells compared to asymptomatic patients and HTLV-1 seronegative controls. HTLV-1 Tax-specific, HLA-A*02 restricted CD8(+ T cells among HAM/TSP individuals expressed markedly lower levels of Tim-3. We observed Tax expressing cells in both Tim-3(+ and Tim-3(- fractions. Taken together, these data indicate that there is a systematic downregulation of Tim-3 levels on T cells in HTLV-1 infection, sustaining a profoundly highly active population of potentially pathogenic T cells that may allow for the development of HTLV-1 complications.

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway.

LENUS (Irish Health Repository)

Cao, Wei

2011-06-01

Emerging experimental data suggest an important role for the T-cell immunoglobulin mucin 1 (Tim-1):Tim-4 pathway in autoimmune and alloimmune responses in vivo. Using a Tim-4 ectodomain human IgG Fc fusion protein we studied the role of Tim-4 in T-cell activation, signalling and differentiation responses in vitro. We demonstrate that Tim-4Fc can inhibit naive and pre-activated T-cell activation, proliferation and cytokine secretion via a Tim-1-independent pathway. Tim-4 contains immunoglobulin variable (IgV) and mucin domains; to identify which domain accounts for the inhibitory effect novel Tim-4 fusion proteins containing either the IgV or mucin domain were generated. We demonstrate that both IgV and mucin domains are required for the inhibitory effects and that they are mediated at least in part by inhibition of extracellular signal-regulated kinase pathway activity. Given the emerging interest in the role of the Tim family in T helper type 17 (Th17) cells, which play an important role in autoimmune disease and transplantation tolerance, our data show that Tim-4Fc can prevent polarization of CD4(+) T cells to the Th17 phenotype. Collectively, our results highlight an inhibitory role for Tim-4Fc in vitro, which we propose is mediated by a receptor other than Tim-1. In addition, this study provides new insights into the role of Tim-4Fc in regulating Th17 immune responses and may open a new avenue for autoimmune therapy.

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway

Science.gov (United States)

Cao, Wei; Ryan, Michelle; Buckley, Deirdre; O'Connor, Rosemary; Clarkson, Michael R

2011-01-01

Emerging experimental data suggest an important role for the T-cell immunoglobulin mucin 1 (Tim-1):Tim-4 pathway in autoimmune and alloimmune responses in vivo. Using a Tim-4 ectodomain human IgG Fc fusion protein we studied the role of Tim-4 in T-cell activation, signalling and differentiation responses in vitro. We demonstrate that Tim-4Fc can inhibit naive and pre-activated T-cell activation, proliferation and cytokine secretion via a Tim-1-independent pathway. Tim-4 contains immunoglobulin variable (IgV) and mucin domains; to identify which domain accounts for the inhibitory effect novel Tim-4 fusion proteins containing either the IgV or mucin domain were generated. We demonstrate that both IgV and mucin domains are required for the inhibitory effects and that they are mediated at least in part by inhibition of extracellular signal-regulated kinase pathway activity. Given the emerging interest in the role of the Tim family in T helper type 17 (Th17) cells, which play an important role in autoimmune disease and transplantation tolerance, our data show that Tim-4Fc can prevent polarization of CD4+ T cells to the Th17 phenotype. Collectively, our results highlight an inhibitory role for Tim-4Fc in vitro, which we propose is mediated by a receptor other than Tim-1. In addition, this study provides new insights into the role of Tim-4Fc in regulating Th17 immune responses and may open a new avenue for autoimmune therapy. PMID:21463297

PENGARUH IKLIM ORGANISASI TERHADAP PRODUKTIVITAS KERJA DI UNIT PELAKSANA TEKNIS KURIKULUM KECAMATAN JASINGA KABUPATEN BOGOR

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Ayi Karyana

2013-03-01

Full Text Available The research analyzed the influence of organizational climate dimension on the work productivity at the Local Technical Service Unit (UPTK for Pre-Elementary and Elementary Education in the Jasinga Sub District of Bogor District. The research used explanatory survey method. Purposive sampling was the technique used to obtained samples. Data were collected by means of questionnaires, interviews and observations. The questionnaires were given to 75 people at the UPTK and they were all returned. The method used to analyze the data is path analysis. Statistical result showed that the variable dimension of the organizational climate has positive and significant impact on the productivity. The UPTK in the Jasinga Sub District of Bogor was totality consistent in giving meaning to the nature of conducive organizational climate. But in order to increase the effectivity and efficiency of the work productivity, it is necessary to socialize the organizations vision and mission, to increase the intensity of the communication, to share responsibility on everybody, to motivate the human resource involved in the job, to encourage reward and punishment, and to provide technological facilities needed to support the organization. Penelitian ini menganalisis pengaruh dimensi iklim organisasi terhadap produktivitas kerja di Unit Pelaksana Teknis Kurikulum (UPTK Kecamatan Jasinga Kabupaten Bogor. Metode penelitian yang digunakan adalah metode survei eksplanatori. Teknik sampling yang digunakan adalah purposive sampling dengan pertimbangan dan bertujuan tertentu. Prosedur pengumpulan data dilakukan dengan penyebaran angket, wawancara dan observasi. Angket disebarkan kepada 75 orang pada UPTK Kecamatan Jasinga, dan angket kembali semuanya. Metode analisis data yang digunakan penulis adalah analisis jalur. Hasil pengujian statistik menunjukkan bahwa dimensi variabel iklim organisasi berpengaruh positif dan signifikan terhadap produktivitas kerja. UPTK Kecamatan Jasinga

Servicing the first web server - Tim Berners-Lee's NeXT

CERN Multimedia

unknown, Association aBCM

2009-01-01

In August 2009 a team from the Association aBCM in Lausanne came to CERN to give the world's first web server a health check under the watchful eye of web pioneer Robert Cailliau. They took an image of the hard drive at this time, copies of which were given to Robert Cailliau and Tim Berners-Lee.

The TimBel synchronization board for time resolved experiments at synchrotron SOLEIL

International Nuclear Information System (INIS)

Ricaud, J.P.; Betinelli-Deck, P.; Bisou, J.; Elattaoui, X.; Laulhe, C.; Monteiro, P.; Nadolski, L.S.; Renaud, G.; Ravy, S.; Silly, M.; Sirotti, F.

2012-01-01

Time resolved experiments are one of the major services that synchrotrons can provide to scientists. The short, high frequency and regular flashes of synchrotron light are a fantastic tool to study the evolution of phenomena over time. To carry out time resolved experiments, beamlines need to synchronize their devices with these flashes of light with a jitter shorter than the pulse duration. For that purpose, Synchrotron SOLEIL has developed the TimBeL (Timing Beamlines) board fully interfaced to TANGO framework. The TimBeL system is a compact PCI board. It is made of a mother with one daughter board. All functions are performed inside a FPGA (Field Programmable Gate Array) implemented on the mother board. A PLX Technology chip is used to communicate with the compact PCI crate. To enable experiments to remain always synchronous with the same bunch of electrons, the storage ring clock (CLK-SR) and the radio frequency clock (CLK-RF) are provided by the machine to beamlines. These clocks are used inside the FPGA as main clocks for state machines. Because the jitter is too large on the FPGA outputs, a daughter board with a jitter cleaner has been added to the system. This board also provides delay lines for compensating time offsets by 10 ps steps. This paper presents the main features required by time resolved experiments and how we achieved our goals with the TimBeL board

Pembuatan Virtual Kampus Sistem Komputer Fakultas Teknik Universitas Diponegoro Menggunakan Jaringan Lokal Berbasis VRML

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Hendra Taufiq Oktafianto

2015-01-01

Full Text Available Dalam bidang informasi banyak cara dalam menginformasikan data, baik secara tertulis, gambar, suara, gambar dan suara. Saat ini banyak dikembangkan teknologi dengan menggunakan metode visual yang interaktif, seperti dunia virtual yang membuat seolah-olah informasi tersebut di dapat sesuai dengan pengalaman memasuki daerah yang di lihat pada dunia virtual tersebut. Metode tersebut adalah pengembangan teknologi virtual reality yang dibuat dengan menggunakan 3DS Max sebagai software untuk menghasilkan gambar yang menarik. Pengaplikasian yang dikembangkan dengan media web dimana setiap pengguna lebih mudah dalam dalam menggunakan aplikasi tersebut. Metode pengambangan yang dirancang adalah memadukan teknologi virtual reality dengan web. Dimana aplikasi tersebut terdapat didalam tampilan web yang didukun basis data untuk mempermudah aktor admin dalam mengolah data. Pada browser yang digunakan akan di pasang plug-in cortona3d agar dapat menampilkan file ekstensi tiga dimensi yang dapat di tampilkan browser. Hasil dari pembuatan aplikasi ini adalah terancangnya sebuah aplikasi yang menggunakan teknologi virtual reality modeling language dengan studi kasus Kampus Sistem Komputer Fakultas Teknik Universitas Diponegoro menggunakan jaringan lokal berbasis VRML

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry

OpenAIRE

Rhein, Bethany A.; Brouillette, Rachel B.; Schaack, Grace A.; Chiorini, John A.; Maury, Wendy

2016-01-01

Phosphatidylserine (PtdSer) receptors that are responsible for the clearance of dying cells have recently been found to mediate enveloped virus entry. Ebola virus (EBOV), a member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells. The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved PtdSer binding pocket within the amin...

U-series dating using thermal ionisation mass spectrometry (TIMS)

International Nuclear Information System (INIS)

McCulloch, M.T.

1999-01-01

U-series dating is based on the decay of the two long-lived isotopes 238 U(τ 1/2 =4.47 x 10 9 years) and 235 U (τ 1/2 0.7 x 10 9 years). 238 U and its intermediate daughter isotopes 234 U (τ 1/2 = 245.4 ka) and 230 Th (τ 1/2 = 75.4 ka) have been the main focus of recently developed mass spectrometric techniques (Edwards et al., 1987) while the other less frequently used decay chain is based on the decay 235 U to 231 Pa (τ 1/2 = 32.8 ka). Both the 238 U and 235 U decay chains terminate at the stable isotopes 206 Pb and 207 Pb respectively. Thermal ionization mass spectrometry (TIMS) has a number of inherent advantages, mainly the ability to measure isotopic ratios at high precision on relatively small samples. In spite of these now obvious advantages, it is only since the mid-1980's when Chen et al., (1986) made the first precise measurements of 234 U and 232 Th in seawater followed by Edwards et al., (1987) who made combined 234 U- 230 Th measurements, was the full potential of mass spectrometric methods first realised. Several examples are given to illustrate various aspects of TIMS U-series

Insights into the fold organization of TIM barrel from interaction energy based structure networks.

Science.gov (United States)

Vijayabaskar, M S; Vishveshwara, Saraswathi

2012-01-01

There are many well-known examples of proteins with low sequence similarity, adopting the same structural fold. This aspect of sequence-structure relationship has been extensively studied both experimentally and theoretically, however with limited success. Most of the studies consider remote homology or "sequence conservation" as the basis for their understanding. Recently "interaction energy" based network formalism (Protein Energy Networks (PENs)) was developed to understand the determinants of protein structures. In this paper we have used these PENs to investigate the common non-covalent interactions and their collective features which stabilize the TIM barrel fold. We have also developed a method of aligning PENs in order to understand the spatial conservation of interactions in the fold. We have identified key common interactions responsible for the conservation of the TIM fold, despite high sequence dissimilarity. For instance, the central beta barrel of the TIM fold is stabilized by long-range high energy electrostatic interactions and low-energy contiguous vdW interactions in certain families. The other interfaces like the helix-sheet or the helix-helix seem to be devoid of any high energy conserved interactions. Conserved interactions in the loop regions around the catalytic site of the TIM fold have also been identified, pointing out their significance in both structural and functional evolution. Based on these investigations, we have developed a novel network based phylogenetic analysis for remote homologues, which can perform better than sequence based phylogeny. Such an analysis is more meaningful from both structural and functional evolutionary perspective. We believe that the information obtained through the "interaction conservation" viewpoint and the subsequently developed method of structure network alignment, can shed new light in the fields of fold organization and de novo computational protein design.

Consumerism, Activism, Intrinsic Motivation, and Balance: An Interview with Tim Kasser

Science.gov (United States)

Keeley, Jared

2010-01-01

A year after receiving his PhD in psychology from the University of Rochester, Tim Kasser accepted a position at Knox College, in Galesburg, Illinois, where he is currently professor of psychology. He regularly teaches psychology classes on personality, clinical and abnormal psychology, dreaming, and research methods, as well as an…

Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant.

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Kerry L Hilligan

Full Text Available Macrophage and dendritic cell (DC populations residing in the intestinal lamina propria (LP are highly heterogeneous and have disparate yet collaborative roles in the promotion of adaptive immune responses towards intestinal antigen. Under steady-state conditions, macrophages are efficient at acquiring antigen but are non-migratory. In comparison, intestinal DC are inefficient at antigen uptake but migrate to the mesenteric lymph nodes (mLN where they present antigen to T cells. Whether such distinction in the roles of DC and macrophages in the uptake and transport of antigen is maintained under immunostimulatory conditions is less clear. Here we show that the scavenger and phosphatidylserine receptor T cell Immunoglobulin and Mucin (TIM-4 is expressed by the majority of LP macrophages at steady-state, whereas DC are TIM-4 negative. Oral treatment with the mucosal adjuvant cholera toxin (CT induces expression of TIM-4 on a proportion of CD103+ CD11b+ DC in the LP. TIM-4+ DC selectively express high levels of co-stimulatory molecules after CT treatment and are detected in the mLN a short time after appearing in the LP. Importantly, intestinal macrophages and DC expressing TIM-4 are more efficient than their TIM-4 negative counterparts at taking up apoptotic cells and soluble antigen ex vivo. Taken together, our results show that CT induces phenotypic changes to migratory intestinal DC that may impact their ability to take up local antigens and in turn promote the priming of mucosal immunity.

DIVERSITAS TIM MANAJEMEN PUNCAK, KEKOMPREHENSIFAN PENGAMBILAN KEPUTUSAN, INTEGRASI SOSIAL DAN KINERJA PERUSAHAAN: STUDI PADA BANK PERKREDITAN RAKYAT

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Arief Prima Johan

2014-07-01

Full Text Available AbstractAlthough research on diversity management team had been widely conducted, previous research defined diversity in many different ways and many studies focused their research on top management team of big companies and big industries. This study examined the influence of several type of diversity of top management team on decision-making comprehensiveness and social integration, and tests these last two variables on performance. Using data Rural Banks (banking industry, the results showed that several variables of diversity of top management team affect decision-making comprehensiveness and social integration. The study also confirmed that the company's performance is affected by decision-making comprehensiveness and social integration.Keywords:Team Management, Diversity, Decision-Making Comprehensiveness, Social Integration, Performance.AbstrakMeskipun penelitian mengenai diversitas tim manajemen sudah banyak dilakukan, tetapi penelitian yang lalu mendefinisikan diversitas dengan cara yang berbeda-beda dan banyak berfokus pada tim manajemen puncak perusahaan besar dan industri besar. Penelitian ini menguji pengaruh variable-variabel diversitas tim manajemen puncak perusahaan terhadap kekomprehensifan pengambilan keputusan dan integrasi sosial, serta menguji dua variable terakhir ini pada kinerja. Dengan menggunakan data Bank Perkreditan Rakyat (industri perbankan, hasil penelitian memperlihatkan bahwa beberapa variable diversitas manajemen puncak mempengaruhi kekomprehensifan pengambilan keputusan dan integrasi sosial.Penelitian juga mengkonfirmasi bahwa kinerja perusahaan dipengaruhi oleh kekomprehensifan pengambilan keputusan dan integrasi sosial.Kata Kunci:Tim Manajemen Puncak, Diversitas, Kekomprehensifan, Pengambilan Keputusan, Integrasi Sosial, Kinerja Perusahaan.

Space Solar Power Exploratory Research and Technology (SERT) Technical Interchange Meeting 2 (SERT TIM 2)

Science.gov (United States)

Howell, Joe; Sanders, Clark W.

2000-01-01

The University of Alabama in Huntsville's (UAH) Propulsion Research Center hosted the Space Solar Power Exploratory Research & Technology (SERT) Technical Interchange Meeting TIM) 2 in Huntsville, Alabama December 7-10. 1999 with 126 people in attendance. The SERT program includes both competitively procured activities. which are being implemented through a portfolio of focused R&D investments--with the maximum leveraging of existing resources inside and outside NASA. and guided by these system studies. Axel Roth. Director of the Flight Projects Directorate NASA MSFC, welcomed the SERT TIM 2 participants and challenged them to develop the necessary technologies and demonstrations that will lead to Space Solar Power (SSP) International implementation. Joe Howell, NASA MSFC, reiterated the SERT TIM 2 objectives: 1) Refining and modeling systems approaches for the utilization of SSP concepts and technologies, ranging, from the near-term e.g. for space science, exploration and commercial space applications to the far-term (e. g. SSP for terrestrial markets), including systems concepts, technology, infrastructure (i.g., transportation), and economics. 2) Conducting technology research, development and demonstration activities to produce "proof- of-concept" validation of critical SSP elements for both the nearer and farther-term applications. 3) Initiating partnerships Nationality and Internationally that could be expanded, as appropriate, to pursue later SSP technology and applications (e.g., space science. colonization, etc.). Day one began with the NASA Centers presenting their SERT activities summary since SERT TIM 1 and wound up with a presentation by Masahiro Mori, NASDA titled "NASDA In-house Study for SSP". Demonstration for the Near-Term. Day two began with the SERT Systems Studies and Analysis reports resulting from NRA 8-23 followed by presentations of SERT Technology Demonstrations reports resulting from NRA 8-23. Day two closed with John Mankins presentation

Infrared spectroscopy for geologic interpretation of TIMS data

Science.gov (United States)

Bartholomew, Mary Jane

1986-01-01

The Portable Field Emission Spectrometer (PFES) was designed to collect meaningful spectra in the field under climatic, thermal, and sky conditions that approximate those at the time of the overflight. The specifications and procedures of PFES are discussed. Laboratory reflectance measurements of rocks and minerals were examined for the purpose of interpreting Thermal Infrared Multispectral Scanner (TIMS) data. The capability is currently being developed to perform direct laboratory measurement of the normal spectral radiance of Earth surface materials at low temperatures (20 to 30 C) at the Jet Propulsion Laboratory.

Up-regulated expression of Tim-3/Gal-9 at maternal-fetal interface in pregnant woman with recurrent spontaneous abortion.

Science.gov (United States)

Li, Jing; Li, Fan-fan; Zuo, Wei; Zhou, Yuan; Hao, Hai-yan; Dang, Jing; Jiang, Min; He, Meng-zhou; Deng, Dong-rui

2014-08-01

The relationship between T cell immunoglobulin domain and mucin domain protein 3 (Tim-3)/Galectin (Gal)-9 pathway and recurrent spontaneous abortion (RSA) was studied. Thirty-one pregnant women with RSA and 27 normal early gravidas were investigated to detect the levels of Tim-3 and Gal-9 in villi and deciduas by Western blotting. Meanwhile, the concentration of interleukin (IL)-4 and IL-12 in peripheral blood plasma was determined by ELISA in 25 healthy fertile non-pregnant controls, the normal early gravidas and pregnant women with RSA mentioned above, respectively. It was found that the relative expression levels of Tim-3 and Gal-9 in villi and deciduas were significantly increased in pregnant women with RSA as compared with those in the normal early gravidas. The concentration of IL-4 in peripheral blood plasma of pregnant women with RSA was lower than that of the normal early gravidas (Ppregnant controls (Ppregnant women with RSA was significantly higher than that of the normal early gravidas (Ppregnant controls (P<0.05). It was suggested that the overexpression of Tim-3/Gal-9 pathway may be related to the pathogenesis of RSA.

Gambaran Perubahan Tekanan Darah Pasca Olahraga Futsal pada Mahasiswa Fakultas Kedokteran Universitas Andalas

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Akdri Andi

2016-08-01

Full Text Available AbstrakPada olahraga tertentu seperti futsal,  tekanan darah dapat naik menjadi 150-200 mmHg. Sebuah penelitian menyatakan  60 kematian mendadak pasca olahraga, 58 diantaranya disebabkan oleh kelainan kardiovaskuler. Tujuan penelitian ini adalah untuk mengetahui gambaran perubahan tekanan darah pasca olahraga futsal pada mahasiswa Fakultas Kedokteran Universitas Andalas. Rancangan penelitian yang digunakan adalah deskriptif observasional dengan menggunakan desain cross-sectional study. Subjek yang digunakan adalah 30 orang mahasiswa Fakultas Kedokteran Universitas Andalas yang memenuhi kriteria inklusi dan eklusi pada April 2014. Olahraga futsal dilakukan 30 menit lalu dilakukan pengukuran tekanan darah sesaat, 15, 30 dan 60 menit dengan menggunakan sphygmomanometer air raksa dan stetoskop. Hasil penelitian didapatkan peningkatan tekanan darah sistolik sesaat setelah olahraga futsal pada semua sampel dengan peningkatan sebesar 20 mmHg pada 18 orang (60% dan 25 orang (83,8% tidak mengalami perubahan tekanan darah diastolik. Pada 15 menit setelah olahraga futsal, 18 orang (60% terjadi penurunan tekanan darah sistolik sebesar 20 mmHg dan 26 orang (86,67% tidak mengalami perubahan tekanan darah diastolik. Pada 30 menit setelah olahraga, 4 orang (13,3% mengalami penurunan tekanan darah sistolik. Satu jam setelah olahraga, semua subjek telah mencapai tekanan darah awal.Kata kuncl: tekanan darah, olahraga futsal sesaat, 15 menit, 30 menit, satu jam AbstractIn certain exercise such as futsal, blood pressure can raise around 150-200 mmHg. A study has identified 60 sudden deaths after sports and 58 were caused by cardiovascular disorders. The objective of this study was to describe changes in blood pressure after futsal exercise in students of Medical Faculty of Andalas University. The design is descriptive observational using a cross-sectional study. The 30 subjects were taken base on inclusion and exclusion criteria. This study was conducted on April

MOTIVASI DAN PILIHAN KARIR MAHASISWA TINGKAT AKHIR FAKULTAS KEDOKTERAN UNIVERSITAS AIRLANGGA, SURABAYA

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Pramita Andarwati

2017-01-01

karir mahasiswa dan motivasi yang mendasarinya. Metode: Jenis penelitian observasional yang dilakukan pada Maret hingga September 2014. Sampel adalah seluruh mahasiswa tingkat akhir Fakultas Kedokteran Universitas Airlangga periode 2009. Pengumpulan data dilakukan dengan kuesioner dandiskusi kelompok terarah Responden ditanyakan tentang pilihan karier dan motivasinya. Analisis data menggunakan uji chi square dan thematic-content analysis. Hasil: Didapat response rate responden sebesar 95,2% (n = 180. Sebagian besar, 62,2% responden memilih karir sebagai klinisi di mana peminatan terbanyak (20,4%adalah spesialis ilmu penyakit dalam. Sementara itu, latar belakang sosial mahasiswa (daerah asal, pendidikan akhir dan profesi orang tua, sumber dana untuk kuliah, kemampuan akademis (Indeks Prestasi Kumulatif dan pengalaman selama masa pendidikan tidak berhubungan dengan pilihan karir (klinisi dan non klinisi. Diungkapkan bahwa keseimbangan karier dan kehidupan keluarga, minat pada bidang tertentu serta besaran penghasilan mendasari pemilihan spesialis. Kesimpulan: Motivasi utama yang mendasari pilihan karir adalah keseimbangan kehidupan pekerjaan dan keluarga, minat pada bidang tertentu serta besaran penghasilan. Saran: Institusi pendidikan, Fakultas Kedokteran Universitas Airlangga diharapkan dapat memberikan motivasi kepada peserta didiknya melalui metode pengajaran yang menarik dan menciptakan lingkungan akademis agar mendukung tumbuhnya minat mempelajari ilmu kedokteran nonklinis dan klinis secara berimbang.  

Application of Circuit Simulation Method for Differential Modeling of TIM-2 Iron Uptake and Metabolism in Mouse Kidney Cells

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Zhijian eXie

2013-06-01

Full Text Available Circuit simulation is a powerful methodology to generate differential mathematical models. Due to its highly accurate modelling capability, circuit simulation can be used to investigate interactions between the parts and processes of a cellular system. Circuit simulation has become a core technology for the field of electrical engineering, but its application in biology has not yet been fully realized. As a case study for evaluating the more advanced features of a circuit simulation tool called Advanced Design System (ADS, we collected and modeled laboratory data for iron metabolism in mouse kidney cells for a H ferritin (HFt receptor, T cell immunoglobulin and mucin domain-2 (TIM-2. The internal controlling parameters of TIM-2 associated iron metabolism were extracted and the ratios of iron movement among cellular compartments were quantified by ADS. The differential model processed by circuit simulation demonstrated a capability to identify variables and predict outcomes that could not be readily measured by in vitro experiments. For example, an initial rate of uptake of iron-loaded HFt was 2.17 pmol per million cells. TIM-2 binding probability with iron-loaded HFt was 16.6%. An average of 8.5 minutes was required for the complex of TIM-2 and iron-loaded HFt to form an endosome. The endosome containing HFt lasted roughly 2 hours. At the end of endocytosis, about 28% HFt remained intact and the rest was degraded. Iron released from degraded HFt was in the labile iron pool (LIP and stimulated the generation of endogenous HFt for new storage. Both experimental data and the model showed that TIM-2 was not involved in the process of iron export. The extracted internal controlling parameters successfully captured the complexity of TIM-2 pathway and the use of circuit simulation-based modeling across a wider range of cellular systems is the next step for validating the significance and utility of this method.

Feto-maternal immune regulation by TIM-3/galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy

DEFF Research Database (Denmark)

Meggyes, Matyas; Lajko, Adrienn; Palkovics, Tamas

2015-01-01

INTRODUCTION: Immunoregulation implies the activation of negative pathways leading to the modulation of specific immune responses. Co-inhibitory receptors (such as PD-1 and TIM-3) represent possible tools for this purpose. PD-1 and TIM-3 have been demonstrated to be present on immune cells...... suggesting general involvement in immunosuppression such as fetomaternal tolerance. The aim of our study was to investigate the expression pattern of PD-1, TIM-3, and its ligand Gal-9 on different immune cell subsets in the peripheral blood and at the fetomaternal interface in pregnant mice. METHODS: TIM-3...... and PD-1 expression by peripheral and decidual immune cells from pregnant BALB-c mice in 2 weeks of gestational age were measures by flow cytometry. Placental galectin-9 expression was determined by immunohistochemically and RT-PCR. RESULTS: Gal-9 was found to be present in the spongiotrophoblast layer...

A multipurpose TIM-based optical telescope for Omega and the Trident laser facilities

International Nuclear Information System (INIS)

Oertel, J.A.; Murphy, T.J.; Berggren, R.R.

1998-01-01

The authors have recently designed and are building a telescope which acts as an imaging light collector relaying the image to an optical table for experiment dependent analysis and recording. The expected primary use of this instrument is a streaked optical pyrometer for witness plate measurements of Hohlraum drive temperature. The telescope is based on University of Rochester's Ten-Inch Manipulator (TIM) which allows compatibility between Omega, Trident, and the NIF lasers. The optics capture a f/7 cone of light, have a field of view of 6-mm, have a spatial resolution of 5 to 7-microm per line pair at the object plane, and are optimized for operation at 280-nm. The image is at a magnification of 11.7x, which is convenient for many experiments, but can be changed using additional optics that reside outside the TIM

ANALISIS KEPUASAN PENGGUNA JASA PEMELIHARAAN DAN PERBAIKAN ATAS PELAYANAN UPT-PP (UNIT PELAKSANA TEKNIS PEMELIHARAAN DAN PERBAIKAN POLITEKNIK NEGERI BALI

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I Made Aryana

2016-01-01

Full Text Available ABSTRACT: PNBis avocational educationinstitution. Withvocationalpredicate,PNBhavediverse learningfacility. In order forthese assetsremainin top condition(ready to use, there should bea specialunit thathandlesmaintenance andrepairissues. UPT-PP (Unit Pelaksana Teknis Pemeliharaan dan Perbaikan isone of the unitsinPNBwhichhas a function asimplementingmaintenanceandrepairsof allassets, and all equipment usedin the activities ofthe learning process. UPT-PP has thefunctions andresponsibilitiesarequite heavyand vitalin supportingthe smoothlearning activitiesboth theory andpractice. This situation demandsUPT-PP shouldhavegoodhuman resources, competent, reliable andshould be supportedbythe provision ofhardwareandsoftwarethat isadequate. This studyaims to determinethe value ofservice usersatisfaction levelof maintenanceandrepair ofservices givenbyUPT-PP Politeknik Negeri Baliandidentify the factorsthat need attentionin order to increaseuser satisfactionwith the servicesUPT-PP Politeknik Negeri Bali. Retrieval of dataobtained from thespread ofthe questioner aboutfacts andrealityassociatedwith service qualityanduser expectationsUPT-PP Politeknik Negeri Bali. While the calculationof thecorrespondence between thelevel of quality anduser expectationsUPT-PP isthe comparison ofthe qualityweightwith the weight ofexpectations/interests. This conformity levelwillshow the level ofuser satisfactionwith the services. Results ofa descriptiveanalysis ofuser satisfactionwith the servicesUPT-PP can be determined bythe value ofthe conformity level. After analysis, the conformitylevelofeachdimensionis obtainedfromthe tangiblevalue81.08%, conformity level of reliability79.04%, conformity level of responsiveness to the valueof81.09%, theassurancedimensionwithvalue84.20% anddimensionsof empathywith the conformity value83.23%. Fromfivedimensions ofconformity level assessment between service qualityexpectationsof service usersUPT-PP Politeknik Negeri Bali is81

Performance characteristics of a Bioassay method for plutonium using thermal ionisation mass spectrometry (TIMS)

Energy Technology Data Exchange (ETDEWEB)

Linauskas, S.H.; Elliot, N.L.; Paterson, L.M.; Totland, M.M

2003-01-01

Plutonium-in-urine analysis by radiochemical isolation of Pu followed by thermal ionisation mass spectrometry (TIMS) is capable of high sensitivity and precision measurements {sup 239}Pu and {sup 240}Pu. Bias and precision estimates for the TIMS bioassay program at Chalk River Laboratories easily met the ANSI N13.30 performance criteria standards with {sup 239}Pu results of 1.5% and 3.0%, respectively. Analytical blanks derived from water, artificial urine and true urine samples did not produce any statistically different results. During a four-year period of development and implementation of {sup 239}Pu measurements by TIMS, average sample blank values were reduced from 3.9 fg (9.0 {mu}Bq) to 0.57 fg (1.3 {mu}Bq). This reduction was achieved through rigorous application of clean-room handling techniques throughout sample processing. Blank data were found to follow a Iognormal distribution, and current detection limit parameters for L{sub c} and L{sub d} at the 95% significance levels are 0.85 fg {sup 239}Pu (2.0 {mu}Bq) and 1.3 fg {sup 239}Pu (3.0 {mu}Bq), respectively. Detection limits in this range are expected to be sufficient to identify intakes of Pu/Am mixtures at levels that are around one-twentieth of an ALl or better under routine monitoring situations for ICRP Type S and Type M inhalation solubility classes. (author)

Determination of La and Nd by thermal ionization mass spectrometry (TIMS) pre-separated by high performance liquid chromatography (HPLC)

International Nuclear Information System (INIS)

Jaison, P.G.; Raut, N.M.; Parab, A.R.; Khodade, P.S.; Govindan, R.; Aggarwal, S.K.

2003-01-01

Determination of La and Nd by TIMS is required for accurate determination of burn-up of nuclear fuels. During their thermal ionization mass spectrometric (TIMS) analysis, 138 Ce and 142 Ce show spectroscopic isobaric interferences at 138 La and 142 Nd, respectively. Hence, it is essential to remove Ce from La and Nd for their accurate isotopic composition determination. Reversed phase high performance liquid chromatography (HPLC) is a promising technique for rapid and effective separation

Cultura digital jovem: as TIMS invadem as periferias, e agora?

Directory of Open Access Journals (Sweden)

Márcia Gonçalves Nogueira

2014-08-01

Full Text Available Objective of this work is to present a literature review on Young and the Digital Cultural transformations caused by the dissemination of Information Technology and Communication Mobile and wireless (TIMS on the outskirts of the metropolitan area of Recife. To this end, we seek to identify how young periphery, high school students of a public school, they experience the Digital Culture in different social spaces; among them the school, scene of many tensions and generational conflicts and language as social and cultural use of these mobile devices. We highlight some theoretical approaches to the phenomenon of mobile communication and the concept of Digital Culture, adopted in this work. Proposing a reflection on the role of school in the current social context of constant cultural and linguistic transformations multimodality of the digital age. Finally, we present an exercise of looking on Youth Cultures, from different theoretical, to better understand the multiple transits covered by surveyed youth to express themselves and make sense of their audiovisual productions, mediated by TIMS. This theoretical argument was used in the dissertation in mathematics education and technology by one of the authors of this article. Therefore, we hope to contribute to further research on Digital Youth Culture in the context of the periphery.

Space Solar Power Technical Interchange Meeting 2: SSP TIM 2

Science.gov (United States)

Sanders, Jim; Hawk, Clark W.

1998-01-01

The 2nd Space Solar Power Technical Interchange Meeting (SSP TIM 2) was conducted September 21st through 24th with the first part consisting of a Plenary session. The summary results of this Plenary session are contained in part one of this report. The attendees were then organized into Working Breakout Sessions and Integrated Product Team (IPT) Sessions for the purpose of conducting in-depth discussions in specific topic areas and developing a consensus as to appropriate study plans and actions to be taken. The Second part covers the Plenary Summary Session, which contains the summary results of the Working Breakout Sessions and IPT Sessions. The appendix contains the list of attendees. The ob'jective was to provide an update for the study teams and develop plans for subsequent study activities. This SSP TIM 2 was initiated and the results reported electronically over the Internet. The International Space Station (ISS) could provide the following opportunities for conducting research and technology (R&T) which are applicable to SSP: (1) Automation and Robotics, (2) Advanced Power Generation, (3) Advanced Power Management & Distribution (PMAD), (4) Communications Systems and Networks, (5) Energy Storage, (6) In Space Propulsion (ISP), (7) Structural Dynamics and Control, and Assembly and (8) Wireless Power Transmission.

Project TIMS (Teaching Integrated Math/Science)

Science.gov (United States)

Edwards, Leo, Jr.

1993-01-01

The goal of this project is to increase the scientific knowledge and appreciation bases and skills of pre-service and in-service middle school teachers, so as to impact positively on teaching, learning, and student retention. This report lists the objectives and summarizes the progress thus far. Included is the working draft of the TIMS (Teaching Integrated Math/Science) curriculum outline. Seven of the eight instructional subject-oriented modules are also included. The modules include informative materials and corresponding questions and educational activities in a textbook format. The subjects included here are the universe and stars; the sun and its place in the universe; our solar system; astronomical instruments and scientific measurements; the moon and eclipses; the earth's atmosphere: its nature and composition; and the earth: directions, time, and seasons. The module not included regards winds and circulation.

Järgmise lainega võivad tulla meile Ühendriikide investorid / Tim Ferland ; interv. Margit Aedla

Index Scriptorium Estoniae

Ferland, Tim

2003-01-01

Eestis asuva Ameerika Kaubanduskoja (ACCE) president Tim Ferland analüüsib Eesti senist arengut, EL-iga liitumise mõju tulevasele majanduslikule arengule, Eesti ning USA majandus- ja kaubandussuhete olukorda

U-series dating using thermal ionisation mass spectrometry (TIMS)

Energy Technology Data Exchange (ETDEWEB)

McCulloch, M.T. [Australian National University, Canberra, ACT (Australia). Research School of Earth Science

1999-11-01

U-series dating is based on the decay of the two long-lived isotopes{sup 238}U({tau}{sub 1/2}=4.47 x 10{sup 9} years) and {sup 235}U ({tau}{sub 1/2} 0.7 x 10{sup 9} years). {sup 238}U and its intermediate daughter isotopes {sup 234}U ({tau}{sub 1/2} = 245.4 ka) and {sup 230}Th ({tau}{sub 1/2} = 75.4 ka) have been the main focus of recently developed mass spectrometric techniques (Edwards et al., 1987) while the other less frequently used decay chain is based on the decay {sup 235}U to {sup 231}Pa ({tau}{sub 1/2} = 32.8 ka). Both the {sup 238}U and {sup 235}U decay chains terminate at the stable isotopes {sup 206}Pb and {sup 207}Pb respectively. Thermal ionization mass spectrometry (TIMS) has a number of inherent advantages, mainly the ability to measure isotopic ratios at high precision on relatively small samples. In spite of these now obvious advantages, it is only since the mid-1980`s when Chen et al., (1986) made the first precise measurements of {sup 234}U and {sup 232}Th in seawater followed by Edwards et al., (1987) who made combined {sup 234}U-{sup 230}Th measurements, was the full potential of mass spectrometric methods first realised. Several examples are given to illustrate various aspects of TIMS U-series 9 refs., 3 figs.

“This is you”: Encountering Shakespeare with Tim Crouch

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Sara Soncini

2017-11-01

Full Text Available This essay considers Tim Crouch's "I Shakespeare", a suite of monologue plays based on "The Tempest" ("I, Caliban", 2003, "A Midsummer Night's Dream" ("I, Peaseblossom", 2004, "Macbeth" ("I, Banquo", 2005, "Twelfth Night" ("I, Malvolio", 2010 and "Julius Caesar" ("I, Cinna (the poet", 2012. While originally designed for a young audience, Crouch's adaptations have been performed in a variety of theatrical contexts that have added new and probably unforeseen dimensions to their negotiations with Shakespeare. In my analysis I turn to the notion of mobility as a key analytical tool to elucidate the method, aims, as well as the broader cultural meaning of Tim Crouch's reworkings. In his hands, Shakespeare is mobilized as a powerful resource to activate spectators and emphasize their co-authorship in the process of theatre. Through a combination of textual strategies and performance methods, the monologues construct the identities of Shakespeare's characters as multiple and mutable and, in parallel, cast their addressees in fluid, often contradictory roles. My main line of argument is that the plays' propensity of motion is rooted in their emphasis on Shakespeare as a highly mobile cultural signifier which seems confirmed by the monologues' journeys outside the UK. The further adaptational practices triggered by these encounters with foreign audiences are testament to the flexibility of Crouch's dramaturgy of process and its aptitude to accommodate new discursive identities and adjust to each new context of reception.

ANALISIS TREND KINERJA PENGAJARAN DOSEN FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA MULAI TAHUN 2010 s.d 2015

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Achmad Fauzi

2016-03-01

Full Text Available Amid the college competition, where public universities are entering a new form of Public Service Agency (BLU, the public universities increasingly in demand to provide more quality services. Hence the focus on service improvement mainly lecturers teaching activities need to be improved from year to year.The better for its existence, the Faculty of Economics UNJ, should run higher education quality assurance has collected. then one way that can be achieved is by doing research on students regarding the level of student satisfaction on the performance of the teaching faculty of Economics diFakultas UNJ. The purpose of this study is to provide an overview of trends faculty performance and give impetus to occur padai improved performance in the coming years. The results of this study are brought average performance trend in the teaching faculty in each department is good, which is the average value moves above trend figures 3,0dengan the conclusion that the students of the Faculty of Economics satisfied with the performance of the teaching lecturer.

Investigation of T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) polymorphisms in essential thrombocythaemia (ET).

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Han, Fuyan; Wang, Guanghai; Li, Yuantang; Tian, Wenjun; Dong, Zhenfang; Cheng, Shiqing; Liu, Yiqing; Qu, Teng; Wang, Xiaoying; Wang, Yong; Zhang, Bingchang; Ju, Ying

2017-07-01

T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) is preferentially expressed on terminally differentiated Th1 cells and inhibits their IFN-γ production. It has been reported that chronic inflammation may be an important driving force for myeloproliferative neoplasms (MPNs). Therefore, we hypothesized that as an important inflammation regulator, TIM-3 may be involved in essential thrombocythaemia (ET). The goal of this study was to investigate whether the -1516G > T, -574G > T and +4259T > G single-nucleotide polymorphisms (SNPs) within the TIM-3 gene contribute to the genetic susceptibility of individuals to ET. Genotyping of the TIM-3 -1516G > T, -574G > T and + 4259T > G SNPs was performed in 175 patients with ET and in 151 controls via a polymerase chain reaction-restriction fragment length polymorphism assay. We also investigated the relationships between the genotypes of each SNP and the risk factors of ET such as routine blood indexes, age and JAK2 V617F mutation. The genotype and allele frequencies of the -1516G > T SNP (p = 0.016 and 0.019, respectively), the -574G > T SNP (p = 0.035 and 0.038, respectively) and the +4259T > G SNP (p = 0.036 and 0.038, respectively) of the ET patients and the controls were significantly different. A haplotype analysis found that the GGT and TGT haplotypes had significantly different distributions between ET and controls (p = 0.041 and 0.041, respectively). However, no significant differences were detected between the genotypes of all SNPs and routine blood indexes, age and JAK2V617F mutation. The -1516G > T, -574G > T and +4259T > G SNPs within TIM-3 gene might play an important role as a genetic risk factor in the pathogenesis of ET.

Regulatory effect of gamma-chain cytokines on expression of TIM-3 on CD8+ T cells in patients with chronic hepatitis B

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DONG Jie

2015-02-01

Full Text Available ObjectiveTo measure the expression of T-cell immunoglobulin- and mucin domain-3-containing molecule 3 (TIM-3 on CD8+ T cells in peripheral blood mononuclear cells (PBMCs among patients with chronic hepatitis B (CHB and to investigate the effect of common gamma-chain cytokines on the expression of TIM-3 on CD8+ T cells in these patients. MethodsFifteen previously untreated patients with CHB who visited the Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, from January to May, 2014, as well as 8 healthy controls, were included in the study. Blood was collected from these subjects, and PBMCs were isolated from blood by Ficoll density gradient centrifugation. PBMCs were separately stimulated with gamma-chain cytokines, interleukin (IL2, IL-7, IL-15, and IL-21, and anti-CD3/CD28, and the untreated cells were used as a negative control. After four days of culture, PBMCs were stained with monoclonal antibody. Flow cytometry was used to measure the expression of TIM-3 on CD8+ T cells. Comparison of continuous data was made by independent-samples t test. ResultsCompared with the untreated group, the anti-CD3/CD28, IL-2, IL-15, and IL-7 groups had significantly increased expression of TIM-3 on CD8+ T cells (9.629%±9.916%, P=0000 1; 3.817%±2.694%, P = 0.000 6; 5.772%±4.732%, P = 0.005 4; 3.560%±2.045%, P = 0.030 2, while the IL-21 group had nonsignificantly increased expression of TIM-3 on CD8+ T cells (2.503%±2.117%, P = 0.934 1. ConclusionAnti-CD3/CD28 and gamma-chain cytokines IL-2, IL-7, and IL-15 can effectively upregulate the expression of TIM-3 on CD8+ T cells in patients with CHB. It indicates that the inhibition of them can not only reduce the expression of TIM-3, but also may enhance the killing function of CD8+ T cells in patients with CHB.

Tim, Jan Lucas ja Karl Robert - vennad üheks kuuks / Maris Laurits

Index Scriptorium Estoniae

Laurits, Maris

2009-01-01

Rakvere Teatri suvelavastuse "Vennad Lõvisüdamed" kaks Karli osatäitjat Jan Lucas Videvik ja Tim Leesnurm ning Joonatani osatäitja Karl Robert Saaremäe tegid Loksal Kaldmaa talus ratsasõiduproove. Üllar Saaremäe lavastuse "Vennad Lõvisüdamed" (Astrid Lindgreni samanimelise jutustuse järgi) esietendus on 11. juunil Rakvere teatri taga aias

Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression.

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Dong, Jianfeng; Cheng, Lijun; Zhao, Minchao; Pan, Xiangfeng; Feng, Zhiqiang; Wang, Dawei

2017-05-01

Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development. Strong antitumor immune responses, especially CD8 + T cell responses, are thought to be essential to effective cancer treatment and are associated with better prognosis in oropharyngeal head and neck squamous cell carcinoma. In this study, we examined the role of the Tim-3/Gal-9 pathway in oropharyngeal head and neck squamous cell carcinoma patients. We found that Gal-9 expression by CD4 + T cells was increased in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients, but not in human papillomavirus-negative oropharyngeal head and neck squamous cell carcinoma patients. Increased Gal-9 secretion by CD4 + T cells presented multiple immunosuppressive effects. Coculturing monocytes with high Gal-9-expressing CD4 + T cells resulted in the expansion of Tim-3 + monocytes, which suppressed interferon gamma production by activated CD8 + T cells. Subsequently, total monocytes incubated with exogenous Gal-9, or high Gal-9-expressing CD4 + T cells, suppressed the expression of interferon gamma by CD8 + T cells. Exogenous Gal-9 and high Gal-9-expressing CD4 + T cells also suppressed the secretion of both interleukin 10 and interleukin 12 by monocytes. These effects are Tim-3/Gal-9-dependent because blocking Tim-3 and/or Gal-9 could enhance the support of CD8 + T cell interferon gamma production and the interleukin 10 and interleukin 12 secretion by monocytes. Together, these data suggest that the high Tim-3 expression in monocytes could be utilized by tumor-promoting Gal-9 expression on CD4 + T cells. Immunotherapy in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients therefore faces an additional challenge posed by Tim-3 and Gal-9 and likely requires the blockade of these

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

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Isabel Gonçalves Silva

2017-08-01

Full Text Available Acute myeloid leukemia (AML is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which includes ligand-dependent activation of ectopically expressed latrophilin 1 and possibly other G-protein coupled receptors leading to increased translation and exocytosis of the immune receptor Tim-3 and its ligand galectin-9. This occurs in a protein kinase C and mTOR (mammalian target of rapamycin-dependent manner. Tim-3 participates in galectin-9 secretion and is also released in a free soluble form. Galectin-9 impairs the anti-cancer activity of cytotoxic lymphoid cells including natural killer (NK cells. Soluble Tim-3 prevents secretion of interleukin-2 (IL-2 required for the activation of cytotoxic lymphoid cells. These results were validated in ex vivo experiments using primary samples from AML patients. This pathway provides reliable targets for both highly specific diagnosis and immune therapy of AML.

Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding

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2013-01-01

Background Human triosephosphate isomerase (HsTIM) deficiency is a genetic disease caused often by the pathogenic mutation E104D. This mutation, located at the side of an abnormally large cluster of water in the inter-subunit interface, reduces the thermostability of the enzyme. Why and how these water molecules are directly related to the excessive thermolability of the mutant have not been investigated in structural biology. Results This work compares the structure of the E104D mutant with its wild type counterparts. It is found that the water topology in the dimer interface of HsTIM is atypical, having a "wet-core-dry-rim" distribution with 16 water molecules tightly packed in a small deep region surrounded by 22 residues including GLU104. These water molecules are co-conserved with their surrounding residues in non-archaeal TIMs (dimers) but not conserved across archaeal TIMs (tetramers), indicating their importance in preserving the overall quaternary structure. As the structural permutation induced by the mutation is not significant, we hypothesize that the excessive thermolability of the E104D mutant is attributed to the easy propagation of atoms' flexibility from the surface into the core via the large cluster of water. It is indeed found that the B factor increment in the wet region is higher than other regions, and, more importantly, the B factor increment in the wet region is maintained in the deeply buried core. Molecular dynamics simulations revealed that for the mutant structure at normal temperature, a clear increase of the root-mean-square deviation is observed for the wet region contacting with the large cluster of interfacial water. Such increase is not observed for other interfacial regions or the whole protein. This clearly suggests that, in the E104D mutant, the large water cluster is responsible for the subunit interface flexibility and overall thermolability, and it ultimately leads to the deficiency of this enzyme. Conclusions Our study

High-precision isotopic characterization of USGS reference materials by TIMS and MC-ICP-MS

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Weis, Dominique; Kieffer, Bruno; Maerschalk, Claude; Barling, Jane; de Jong, Jeroen; Williams, Gwen A.; Hanano, Diane; Pretorius, Wilma; Mattielli, Nadine; Scoates, James S.; Goolaerts, Arnaud; Friedman, Richard M.; Mahoney, J. Brian

2006-08-01

The Pacific Centre for Isotopic and Geochemical Research (PCIGR) at the University of British Columbia has undertaken a systematic analysis of the isotopic (Sr, Nd, and Pb) compositions and concentrations of a broad compositional range of U.S. Geological Survey (USGS) reference materials, including basalt (BCR-1, 2; BHVO-1, 2), andesite (AGV-1, 2), rhyolite (RGM-1, 2), syenite (STM-1, 2), granodiorite (GSP-2), and granite (G-2, 3). USGS rock reference materials are geochemically well characterized, but there is neither a systematic methodology nor a database for radiogenic isotopic compositions, even for the widely used BCR-1. This investigation represents the first comprehensive, systematic analysis of the isotopic composition and concentration of USGS reference materials and provides an important database for the isotopic community. In addition, the range of equipment at the PCIGR, including a Nu Instruments Plasma MC-ICP-MS, a Thermo Finnigan Triton TIMS, and a Thermo Finnigan Element2 HR-ICP-MS, permits an assessment and comparison of the precision and accuracy of isotopic analyses determined by both the TIMS and MC-ICP-MS methods (e.g., Nd isotopic compositions). For each of the reference materials, 5 to 10 complete replicate analyses provide coherent isotopic results, all with external precision below 30 ppm (2 SD) for Sr and Nd isotopic compositions (27 and 24 ppm for TIMS and MC-ICP-MS, respectively). Our results also show that the first- and second-generation USGS reference materials have homogeneous Sr and Nd isotopic compositions. Nd isotopic compositions by MC-ICP-MS and TIMS agree to within 15 ppm for all reference materials. Interlaboratory MC-ICP-MS comparisons show excellent agreement for Pb isotopic compositions; however, the reproducibility is not as good as for Sr and Nd. A careful, sequential leaching experiment of three first- and second-generation reference materials (BCR, BHVO, AGV) indicates that the heterogeneity in Pb isotopic compositions

Tim Peake and Britain's road to space

CERN Document Server

Seedhouse, Erik

2017-01-01

This book puts the reader in the flight suit of Britain’s first male astronaut, Tim Peake. It chronicles his life, along with the Principia mission and the down-to-the-last-bolt descriptions of life aboard the ISS, by way of the hurdles placed by the British government and the rigors of training at Russia’s Star City military base. In addition, this book discusses the learning curves required in astronaut and mission training and the complexity of the technologies required to launch an astronaut and keep them alive for months on end. This book underscores the fact that technology and training, unlike space, do not exist in a vacuum; complex technical systems, like the ISS, interact with the variables of human personality, and the cultural background of the astronauts. .

Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9.

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Schwartz, Jordan Ari; Clayton, Kiera L; Mujib, Shariq; Zhang, Hongliang; Rahman, A K M Nur-Ur; Liu, Jun; Yue, Feng Yun; Benko, Erika; Kovacs, Colin; Ostrowski, Mario A

2017-04-15

In chronic diseases, such as HIV infection, plasmacytoid dendritic cells (pDCs) are rendered dysfunctional, as measured by their decreased capacity to produce IFN-α. In this study, we identified elevated levels of T cell Ig and mucin-domain containing molecule-3 (Tim-3)-expressing pDCs in the blood of HIV-infected donors. The frequency of Tim-3-expressing pDCs correlated inversely with CD4 T cell counts and positively with HIV viral loads. A lower frequency of pDCs expressing Tim-3 produced IFN-α or TNF-α in response to the TLR7 agonists imiquimod and Sendai virus and to the TLR9 agonist CpG. Thus, Tim-3 may serve as a biomarker of pDC dysfunction in HIV infection. The source and function of Tim-3 was investigated on enriched pDC populations from donors not infected with HIV. Tim-3 induction was achieved in response to viral and artificial stimuli, as well as exogenous IFN-α, and was PI3K dependent. Potent pDC-activating stimuli, such as CpG, imiquimod, and Sendai virus, induced the most Tim-3 expression and subsequent dysfunction. Small interfering RNA knockdown of Tim-3 increased IFN-α secretion in response to activation. Intracellular Tim-3, as measured by confocal microscopy, was dispersed throughout the cytoplasm prior to activation. Postactivation, Tim-3 accumulated at the plasma membrane and associated with disrupted TLR9 at the submembrane. Tim-3-expressing pDCs had reduced IRF7 levels. Furthermore, intracellular Tim-3 colocalized with p85 and IRF7 within LAMP1 + lysosomes, suggestive of a role in degradation. We conclude that Tim-3 is a biomarker of dysfunctional pDCs and may negatively regulate IFN-α, possibly through interference with TLR signaling and recruitment of IRF7 and p85 into lysosomes, enhancing their degradation. Copyright © 2017 by The American Association of Immunologists, Inc.

A novel method for sampling the suspended sediment load in the tidal environment using bi-directional time-integrated mass-flux sediment (TIMS) samplers

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Elliott, Emily A.; Monbureau, Elaine; Walters, Glenn W.; Elliott, Mark A.; McKee, Brent A.; Rodriguez, Antonio B.

2017-12-01

Identifying the source and abundance of sediment transported within tidal creeks is essential for studying the connectivity between coastal watersheds and estuaries. The fine-grained suspended sediment load (SSL) makes up a substantial portion of the total sediment load carried within an estuarine system and efficient sampling of the SSL is critical to our understanding of nutrient and contaminant transport, anthropogenic influence, and the effects of climate. Unfortunately, traditional methods of sampling the SSL, including instantaneous measurements and automatic samplers, can be labor intensive, expensive and often yield insufficient mass for comprehensive geochemical analysis. In estuaries this issue is even more pronounced due to bi-directional tidal flow. This study tests the efficacy of a time-integrated mass sediment sampler (TIMS) design, originally developed for uni-directional flow within the fluvial environment, modified in this work for implementation the tidal environment under bi-directional flow conditions. Our new TIMS design utilizes an 'L' shaped outflow tube to prevent backflow, and when deployed in mirrored pairs, each sampler collects sediment uniquely in one direction of tidal flow. Laboratory flume experiments using dye and particle image velocimetry (PIV) were used to characterize the flow within the sampler, specifically, to quantify the settling velocities and identify stagnation points. Further laboratory tests of sediment indicate that bidirectional TIMS capture up to 96% of incoming SSL across a range of flow velocities (0.3-0.6 m s-1). The modified TIMS design was tested in the field at two distinct sampling locations within the tidal zone. Single-time point suspended sediment samples were collected at high and low tide and compared to time-integrated suspended sediment samples collected by the bi-directional TIMS over the same four-day period. Particle-size composition from the bi-directional TIMS were representative of the array of

Integrated Modeling System for Analysis of Watershed Water Balance: A Case Study in the Tims Branch Watershed, South Carolina

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Setegn, S. G.; Mahmoudi, M.; Lawrence, A.; Duque, N.

2015-12-01

The Applied Research Center at Florida International University (ARC-FIU) is supporting the soil and groundwater remediation efforts of the U.S. Department of Energy (DOE) Savannah River Site (SRS) by developing a surface water model to simulate the hydrology and the fate and transport of contaminants and sediment in the Tims Branch watershed. Hydrological models are useful tool in water and land resource development and decision-making for watershed management. Moreover, simulation of hydrological processes improves understanding of the environmental dynamics and helps to manage and protect water resources and the environment. MIKE SHE, an advanced integrated modeling system is used to simulate the hydrological processes of the Tim Branch watershed with the objective of developing an integrated modeling system to improve understanding of the physical, chemical and biological processes within the Tims Branch watershed. MIKE SHE simulates water flow in the entire land based phase of the hydrological cycle from rainfall to river flow, via various flow processes such as, overland flow, infiltration, evapotranspiration, and groundwater flow. In this study a MIKE SHE model is developed and applied to the Tim branch watershed to study the watershed response to storm events and understand the water balance of the watershed under different climatic and catchment characteristics. The preliminary result of the integrated model indicated that variation in the depth of overland flow highly depend on the amount and distribution of rainfall in the watershed. The ultimate goal of this project is to couple the MIKE SHE and MIKE 11 models to integrate the hydrological component in the land phase of hydrological cycle and stream flow process. The coupled MIKE SHE/MIKE 11 model will further be integrated with an Ecolab module to represent a range of water quality, contaminant transport, and ecological processes with respect to the stream, surface water and groundwater in the Tims

Tim Allen, one of Hollywood's top comedy actors with Rolf Landua from CERN

CERN Multimedia

Laurent Guiraud

2000-01-01

Tim Allen ('Galaxy Quest', 'For Richer and Poorer', 'The Santa Clause', Voice of 'Buzz Lightyear', in Toy Story 1 and 2), visited CERN in July 2000. He has a keen interest in modern physics. In his last book "I'm not really here" he contemplates the funny and the intriguing aspects of quantum physics in his daily life.

La banda sonora del programa «Rá-Tim-Bum»

OpenAIRE

Almeida Duarte, Mônica de

2005-01-01

Esta comunicación trata de los resultados parciales de la investigación vuelta para el análisis de la banda sonora del programa televisivo Rá-Tim-Bum, de TV Educativa, empresa gubernamental. Se utiliza un cuadro teórico-metodológico de análisis de los discursos aplicado a la música propuesto por Amparo Porta por medio de tres niveles de aproximación: verosimilitud referencial (las calidades sonoras), poética (tratamiento de frases y de finalización) y tópica (ideologia difundida). El...

PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

International Nuclear Information System (INIS)

Kong, Y; Zhang, J; Claxton, D F; Ehmann, W C; Rybka, W B; Zhu, L; Zeng, H; Schell, T D; Zheng, H

2015-01-01

Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed. T cells are pivotal in eradicating leukemia through a graft versus leukemia (GVL) effect and leukemia relapse is considered a failure of GVL. T-cell exhaustion is a state of T-cell dysfunction mediated by inhibitory molecules including programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain and mucin domain 3 (TIM-3). To evaluate whether T-cell exhaustion and inhibitory pathways are involved in leukemia relapse post alloSCT, we performed phenotypic and functional studies on T cells from peripheral blood of acute myeloid leukemia patients receiving alloSCT. Here we report that PD-1 hi TIM-3 + cells are strongly associated with leukemia relapse post transplantation. Consistent with exhaustion, PD-1 hi TIM-3 + T cells are functionally deficient manifested by reduced production of interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). In addition, these cells demonstrate a phenotype consistent with exhausted antigen-experienced T cells by losing T N and T EMRA subsets. Importantly, increase of PD-1 hi TIM-3 + cells occurs before clinical diagnosis of leukemia relapse, suggesting their predictive value. Results of our study provide an early diagnostic approach and a therapeutic target for leukemia relapse post transplantation

High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals.

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Stefan Ryser

Full Text Available We report here the cloning of native high affinity anti-TIM-3 and anti-KIR IgG monoclonal antibodies (mAbs from peripheral blood mononuclear cells (PBMC of healthy human donors. The cells that express these mAbs are rare, present at a frequency of less than one per 105 memory B-cells. Using our proprietary multiplexed screening and cloning technology CellSpot™ we assessed the presence of memory B-cells reactive to foreign and endogenous disease-associated antigens within the same individual. When comparing the frequencies of antigen-specific memory B-cells analyzed in over 20 screening campaigns, we found a strong correlation of the presence of anti-TIM-3 memory B-cells with memory B-cells expressing mAbs against three disease-associated antigens: (i bacterial DNABII proteins that are a marker for Gram negative and Gram positive bacterial infections, (ii hemagglutinin (HA of influenza virus and (iii the extracellular domain of anaplastic lymphoma kinase (ALK. One of the native anti-KIR mAbs has similar characteristics as lirilumab, an anti-KIR mAb derived from immunization of humanized transgenic mice that is in ongoing clinical trials. It is interesting to speculate that these native anti-TIM-3 and anti-KIR antibodies may function as natural regulatory antibodies, analogous to the pharmacological use in cancer treatment of engineered antibodies against the same targets. Further characterization studies are needed to define the mechanisms through which these native antibodies may function in healthy and disease conditions.

LITERASI MEDIA SEBAGAI STRATEGI KOMUNIKASI TIM SUKSES RELAWAN PEMENANGAN PEMILIHAN PRESIDEN JOKOWI JK DI BANDUNG

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Annisa Senova

2016-12-01

Full Text Available Memahami kegiatan literasi media yang terjadi dalam kehidupan berorganisasi akan memberikan gambaran yang jelas tentang kemampuan mengidentifikasi, menentukan, mengorganisir, dan menggunakan media, serta menjadikan informasi sebagai bahan pertimbangan pembuatan keputusan tim sukses relawan pemenangan Presiden Joko Widodo dan Jusuf Kalla di Bandung. Oleh karena itu, penelitian ini dilakukan untuk menemukan kegiatan literasi media sebagai strategi komunikasi tim sukses relawan pemenangan pemilihan presiden Joko Widodo dan Jusuf Kalla. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan pendekatan studi kasus. Penelitian ini menggunakan teknik pengumpulan data berupa wawancara mendalam, observasi, dan studi dokumentasi. Teknik pemeriksaan keabsahan data yang digunakan dalam penelitian ini adalah dengan triangulasi data sumber. Media sosial menjadi media utama dalam proses penyampaian pesan kepada khalayak di kota Bandung. Terdapat beberapa jenis media sosial yang akan digunakan secara rutin dalam proses tersebut, yaitu Twitter, Facebook, Instagram, dan Youtube. Namun, timses relawan media sosial hanya fokus kepada dua jenis media sosial yang dianggap dapat mempengaruhi pandangan publik. Twiter dan Instagram dianggap mampu menjadi jejaring sosial yang efektif dalam proses penyampaian pesan politik pemilu 2014. Penyampaian informasi oleh timses relawan media sosial kepada masyarakat melalui Twitter dan Instagram dianggap sangat efektif dan tepat. Konten-konten yang disediakan oleh akun Twitter sangat mudah untuk diakses oleh semua kalangan. Penelitian tantang proses literasi media tim sukses relawan pemenangan presiden Jokowi-Jk ini dapat menambah masukan bagi ilmu komunikasi, terutama dalam bidang literasi media, bahwa saat ini keberadaan media dapat menjadi sebuah strategi komunikasi yang cukup efektif.   DOI: 10.24198/jkk.vol4n2.3

Statins reduce the expressions of Tim-3 on NK cells and NKT cells in atherosclerosis.

Science.gov (United States)

Zhang, Na; Zhang, Min; Liu, Ru-Tao; Zhang, Peng; Yang, Chun-Lin; Yue, Long-Tao; Li, Heng; Li, Yong-Kang; Duan, Rui-Sheng

2018-02-15

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have an immuno-regulatory effect in addition to lowing-lipids. Accumulated evidence showed that the expressions of T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) on natural killer (NK) cells increased in atherosclerotic patients and animal models. In this study, 14 patients treated with rosuvastatin and 12 patients with atorvastatin for more than 3 months were included and 20 patients without statins treatment as control. Both statins treatment reduced the expressions of Tim-3 on NK cells and their subtypes, natural killer T (NKT) cells and CD3 + T cells, and increased the proportions of NKT cells among peripheral blood mononuclear cells, accompanied by the decreased levels of total cholesterol, low density lipoprotein, and increased ratios of high density lipoprotein to cholesterol. These may contribute to the functions of statins in the treatment of atherosclerosis. Copyright © 2017 Elsevier B.V. All rights reserved.

Effect of difference between group constants processed by codes TIMS and ETOX on integral quantities

International Nuclear Information System (INIS)

Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

1978-06-01

Group constants of 235 U, 238 U, 239 Pu, 240 Pu and 241 Pu have been produced with the processing code TIMS using the evaluated nuclear data of JENDL-1. The temperature and composition dependent self-shielding factors have been calculated for the two cases with and without considering mutual interference resonant nuclei. By using the group constants set produced by the TIMS code, the integral quantities, i.e. multiplication factor, Na-void reactivity effect and Doppler reactivity effect, are calculated and compared with those calculated with the use of the cross sections set produced by the ETOX code to evaluate accuracy of the approximate calculation method in ETOX. There is much difference in self-shielding factor in each energy group between the two codes. For the fast reactor assemblies under study, however, the integral quantities calculated with these two sets are in good agreement with each other, because of eventual cancelation of errors. (auth.)

TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens

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Yoshihisa Hiraishi

2016-10-01

Conclusions: Our findings indicate that, in mice, TIM-3 is not essential for development of HDM-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM-induced chronic allergic airway inflammation.

STRATEGI PENINGKATAN KINERJA PROGRAM STUDI MELALUI OPTIMALISASI PERAN PIMPINAN

Directory of Open Access Journals (Sweden)

S. Martono

2013-03-01

Full Text Available Tujuan dari penelitian ini adalah mengungkap pengaruh gaya kepemimpinan terhadap budaya organsiasi, kerjasama tim dan kinerja organisasi. Tugas dan peran seorang pemimpin di tingkat unit organisasi sangat menentukan kualitas kerja. Fakta di lingkungan perguruan tinggi menunjukkan bahwa tidak semua pimpinan mampu memahami Prodi secara utuh. Sampel ditentukan dengan proportional random sampling berjumlah 139 orang. Variabel penelitian meliputi gaya kepemimpinan, kerjasama tim, budaya organisasi, dan kinerja organisasi. Data dikumpulkan dengan angket, analisis menggunakan Structural Equation Modeling (SEM. Hasil penelitian menunjukkan variabel gaya kepemimpinan tidak berpengaruh langsung terhadap kinerja organisasi prodi, tetapi berpengaruh tidak langsung melalui budaya organisasi dan kerjasama tim. Variabel kerjasama tim berpengaruh langsung maupun tidak langsung melalui budaya organisasi, terhadap kinerja organisasi Prodi. Saran dari penelitian ini adalah pimpinan mengembangkan budaya kerja melalui pemberian contoh, sikap dan perilaku dalam memanfaatkan sumber daya yang ada di fakultas, jurusan dan prodi. The objective of this study is to analyze the influence of leadership styles on an organizational culture, teamwork and organizational performance. Behavior and how a head department plays a role of a leader will determine people work quality. There are findings that in universities, not all leaders are able to comprehensively understand what program department scope’s is. The sample was determined by proportional random sampling totaled 139 people. The variables of study include leadership styles, teamwork, organizational culture, and organizational performance. Data were collected by questionnaires, analysis using Structural Equation Modeling (SEM. The results showed leadership style variable does not directly influence organizational performance of program department, but indirectly through the influence of organizational culture and

IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast cancer

Energy Technology Data Exchange (ETDEWEB)

Heon, Elise K. [University of Maryland Medical Center, Baltimore, MD 21201 (United States); Wulan, Hasi [Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing, 100853 (China); Macdonald, Loch P.; Malek, Adel O.; Braunstein, Glenn H.; Eaves, Connie G.; Schattner, Mark D. [Brown University, Providence, RI 02912 (United States); Allen, Peter M.; Alexander, Michael O.; Hawkins, Cynthia A.; McGovern, Dermot W.; Freeman, Richard L. [University of Wisconsin, Madison, WI 53706 (United States); Amir, Eitan P.; Huse, Jason D. [University of Illinois, Chicago, IL 60607 (United States); Zaltzman, Jeffrey S.; Kauff, Noah P.; Meyers, Paul G. [University of Texas, Austin, TX 78712 (United States); Gleason, Michelle H., E-mail: GleasonM@cblabs.org [University of Texas, Austin, TX 78712 (United States); Overholtzer, Michael G., E-mail: OverholtzerM@cblabs.org [University of Texas, Austin, TX 78712 (United States); Wiseman, Sam S. [Ohio State University, Columbus, OH 43210 (United States); and others

2015-08-14

IL-15 has pivotal roles in the control of CD8{sup +} memory T cells and has been investigated as a therapeutic option in cancer therapy. Although IL-15 and IL-2 share many functions together, including the stimulation of CD8 T cell proliferation and IFN-γ production, the different in vivo roles of IL-15 and IL-2 have been increasingly recognized. Here, we explored the different effects of IL-15 and IL-2 on tumor-infiltrating (TI) T cells from resected breast tumors. We found that neither IL-2 nor IL-15 induced intratumoral CD8 T cell proliferation by itself, but after CD3/CD28-stimulation, IL-15 induced significantly higher proliferation than IL-2 during early time points, at day 2, day 3 and day 6. However, the IL-15-induced proliferation leveled off at day 9 and day 12, whereas IL-2 induced lower but progressive proliferation at each time point. Furthermore, IL-15 caused an early and robust increase of IFN-γ in the supernatant of TI cell cultures, which diminished at later time points, while the IL-2-induced IFN-γ production remained constant over time. In addition, the IL-15-costimulated CD8 T cells presented higher frequencies of apoptotic cells. The diminishing IL-15-induced response was possibly due to regulatory and/or exhaustion mechanisms. We did not observe increased IL-10 or PD-1 upregulation, but we have found an increase of Tim-3 upregulation on IL-15-, but not IL-2-stimulated cells. Blocking Tim-3 function using anti-Tim-3 antibodies resulted in increased IL-15-induced proliferation and IFN-γ production for a prolonged period of time, whereas adding Tim-3 ligand galectin 9 led to reduced proliferation and IFN-γ production. Our results suggest that IL-15 in combination of Tim-3 blocking antibodies could potentially act as an IL-2 alternative in tumor CD8 T cell expansion in vitro, a crucial step in adoptive T cell therapy. - Highlights: • We explored the effects of IL-15 and IL-2 on tumor-infiltrating (TI) T cells of breast cancer. • IL-15

Approaches to vegetation mapping and ecophysiological hypothesis testing using combined information from TIMS, AVIRIS, and AIRSAR

Science.gov (United States)

Oren, R.; Vane, G.; Zimmermann, R.; Carrere, V.; Realmuto, V.; Zebker, Howard A.; Schoeneberger, P.; Schoeneberger, M.

1991-01-01

The Tropical Rainforest Ecology Experiment (TREE) had two primary objectives: (1) to design a method for mapping vegetation in tropical regions using remote sensing and determine whether the result improves on available vegetation maps; and (2) to test a specific hypothesis on plant/water relations. Both objectives were thought achievable with the combined information from the Thermal Infrared Multispectral Scanner (TIMS), Airborne Visible/Infrared Imaging Spectrometer (AVIRIS), and Airborne Synthetic Aperture Radar (AIRSAR). Implicitly, two additional objectives were: (1) to ascertain that the range within each variable potentially measurable with the three instruments is large enough in the site, relative to the sensitivity of the instruments, so that differences between ecological groups may be detectable; and (2) to determine the ability of the three systems to quantify different variables and sensitivities. We found that the ranges in values of foliar nitrogen concentration, water availability, stand structure and species composition, and plant/water relations were large, even within the upland broadleaf vegetation type. The range was larger when other vegetation types were considered. Unfortunately, cloud cover and navigation errors compromised the utility of the TIMS and AVIRIS data. Nevertheless, the AIRSAR data alone appear to have improved on the available vegetation map for the study area. An example from an area converted to a farm is given to demonstrate how the combined information from AIRSAR, TIMS, and AVIRIS can uniquely identify distinct classes of land use. The example alludes to the potential utility of the three instruments for identifying vegetation at an ecological scale finer than vegetation types.

The Filmmaker as Humanist: An Interview with Tim Robbins on the Making of "Cradle Will Rock".

Science.gov (United States)

Mason, Terrence C.

2000-01-01

Presents an interview with Tim Robbins that focuses on the making of the film "Cradle Will Rock." Robbins offers his perspectives on issues such as the power of art to convey important social messages and sources of violence in schools. Includes resources for teachers. (CMK)

El De imaginibus caelestibus de Ibn al-Ḥātim

OpenAIRE

Oliveras, Marc

2009-01-01

En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥāt...

Perancangan dan Implementasi Sistem Informasi Perpustakaan di Program Studi Teknik Lingkungan Fakultas Teknik Undip

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Lia Dorothy

2014-11-01

Full Text Available Perkembangan teknologi informasi menciptakan keunggulan kompetitif dalam berbagai bidang. Perkembangan ini didukung oleh industri perangkat keras dan perangkat lunak komputer yang terus berkembang, yakni dengan pengaksesan dan pemrosesan informasi yang cepat, akurat, dan efisien melalui sebuah sistem informasi. Pengelolaan data buku di perpustakaan Teknik Lingkungan masih dilakukan menggunakan microsoft office excel, sedangkan pengelolaan data anggota dan data peminjaman masih dicatat secara manual. Oleh karena itu, diperlukan sebuah penelitian untuk membangun sebuah sistem informasi perpustakaan yang dapat mempermudah pengelolaan data dan aktivitas perpustakaan di Program Studi Teknik Lingkungan. Sistem informasi perpustakaan terkomputerisasi ini diharapkan dapat membantu pengelolaan data buku dan data anggota, transaksi peminjaman dan pengembalian buku, serta menghasilkan laporan untuk keperluan administrasi perpustakaan, sehingga dapat meningkatkan efektifitas kinerja karyawan. Sistem informasi perpustakaan ini berbasis web, dikembangkan dengan bahasa pemrograman PHP dan basis data MySQL, serta menggunakan framework CodeIgniter. Sistem informasi ini juga dilengkapi dengan barcode reader yang digunakan untuk mempermudah pengelolaan data buku. Penelitian dikembangkan dengan metode SDLC (System Development Life Cycle. Langkah-langkah penelitian meliputi tahap perencanaan, tahap analisis, tahap perancangaan, tahap implementasi, tahap pengujian, dan tahap pemeliharaan. Sistem dirancang dengan menggunakan diagram UML (Unified Modelling Language dan diuji dengan pengujian kotak hitam (blackbox testing. Semua menu dalam sistem informasi perpustakaan dan barcode reader dapat bekerja dengan baik. Sistem informasi perpustakaan telah diimplementasikan di Program Studi Teknik Lingkungan Fakultas Teknik UNDIP. Sistem informasi ini menambah kualitas pelayanan pada perpustakaan Teknik Lingkungan.

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis.

Science.gov (United States)

Fleury, Michelle; Belkina, Anna C; Proctor, Elizabeth A; Zammitti, Christopher; Simms, Robert W; Lauffenburger, Douglas A; Snyder-Cappione, Jennifer E; Lafyatis, Robert; Dooms, Hans

2018-04-01

Immune dysfunction is an important component of the disease process underlying systemic sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. This study was undertaken to measure the expression and function of the coinhibitory receptors (co-IRs) programmed cell death 1 (PD-1), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin domain 3 (TIM-3), and lymphocyte activation gene 3 (LAG-3) in lymphocyte subsets from the peripheral blood of patients with SSc. Co-IR expression levels on subsets of immune cells were analyzed using a 16-color flow cytometry panel. The functional role of co-IRs was determined by measuring cytokine production after in vitro stimulation of SSc and healthy control peripheral blood mononuclear cells (PBMCs) in the presence of co-IR-blocking antibodies. Supernatants from cultures of stimulated PBMCs were added to SSc fibroblasts, and their impact on fibroblast gene expression was measured. Mathematical modeling was used to reveal differences between co-IR functions in SSc patients and healthy controls. Levels of the co-IRs PD-1 and TIGIT were increased, and each was coexpressed, in distinct T cell subsets from SSc patients compared to healthy controls. Levels of TIM-3 were increased in SSc natural killer cells. PD-1, TIGIT, and TIM-3 antibody blockade revealed patient-specific roles of each of these co-IRs in modulating activation-induced T cell cytokine production. In contrast to healthy subjects, blockade of TIGIT and TIM-3, but not PD-1, failed to reverse inhibited cytokine production in SSc patients, indicating that enhanced T cell exhaustion is present in SSc. Finally, cytokines secreted in anti-TIM-3-treated PBMC cultures distinctly changed the gene expression profile in SSc fibroblasts. The altered expression and regulatory capacity of co-IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine-mediated cross-talk of

TIMS-1: a processing code for production of group constants of heavy resonant nuclei

International Nuclear Information System (INIS)

Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

1980-09-01

The TIMS-1 code calculates the infinitely dilute group cross sections and the temperature dependent self-shielding factors for arbitrary values of σ 0 and R, where σ 0 is the effective background cross section of potential scattering and R the ratio of the atomic number densities for two resonant nuclei if any. This code is specifically programmed to use the evaluated nuclear data file of ENDF/B or JENDL as input data. In the unresolved resonance region, the resonance parameters and the level spacings are generated by using Monte Carlo method from the Porter-Thomas and Wigner distributions respectively. The Doppler broadened cross sections are calculated on the ultra-fine lethargy meshes of about 10 -3 -- 10 -5 using the generated and resolved resonance parameters. The effective group constants are calculated by solving the neutron slowing down equation with the use of the recurrence formula for the neutron slowing down source. The output of the calculated results is given in a format being consistent with the JAERI-Fast set (JFS) or the Standard Reactor Analysis Code (SRAC) library. Both FACOM 230/75 and M200 versions of TIMS-1 are available. (author)

Minat Mahasiswa Setelah Lulus Kuliah Terhadap Entrepreneurs: Studi Kasus Mahasiswa Peserta Pelatihan Entrepreneurship Fakultas Agama Islam Universitas Darul ‘Ulum Jombang Tahun 2015

Directory of Open Access Journals (Sweden)

A. Syafi' AS

2016-06-01

Full Text Available Kewirausahaan (entrepreneurship adalah kemampuan kreatif dan inovatif dalam menciptakan nilai tambah di pasar melalui proses pengelolaan sumber daya dengan cara-cara baru dan berbeda. Di Indonesia, kewirausahaan dipelajari baru terbatas pada beberapa sekolah atau perguruan tinggi tertentu saja. Program yang dilakukan oleh Fakultas Agama Islam Universitas Darul ‘Ulum Jombang ditambah dengan adanya bantuan penguatan entrepreneurs centre PTKI tahun 2015 dari Direktorat Pendidikan Tinggi Islam Kementerian Agama RI dapat menjadi batu loncatan bagi mahasiswa Fakultas Agama Islam Universitas Darul ‘Ulum Jombang yang ingin membuka usaha pada saat lulus kuliah nanti. Penelitian ini merupakan SWOT analasis tentang minat mahasiswa peserta entrepreneursip mahasiswa Fakultas Agama Islam Universitas Darul ‘Ulum Jombang setelah lulus kuliah terhadap entrepreneurship. Teknik pengumpulan datanya melalui observasi, wawancara, angket dan dokumentasi. Berdasarkan hasil penelitian yang didapat adalah sebanyak 63.48% perempuan dan 66.05% laki-laki ingin membuka usaha setelah lulus, artinya minat menjadi wirausaha lebih besar pada mahasiswa laki-laki. Mahasiswa yang ingin bekerja setelah lulus adalah 24.17% perempuan dan 26.12% laki-laki. Untuk mahasiswa yang ingin menjadi Pegawai Negri Sipil setelah lulus hampir berimbang, yaitu 5.19% perempuan dan 5.23% laki-laki. Sedangkan yang menginginkan menjadi guru lebih banyak terjadi pada mahasiswa perempuan, yaitu 7.16% dan hanya 2.14% dari mahasiswa laki-laki. Yang paling menarik dalam temuan penelitian ini adalah didapatnya 0.46% mahasiswa laki-laki yang ingin menjadi ABRI pada saat lulus kuliah, melihat latar belakang data yang di dapat mahasiswa yang ingin jadi ABRI dilatarbelakangi oleh orangtuanya yang memang ABRI. || Entrepreneurship is the ability to be creative and innovative in creating added value in the market through the process of managing resources in new dan different ways. In Indonesia, a new study of

Ontology and anthropology of interanimality: Merleau-Ponty from Tim ingold's perspective

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Ana Cristina Ramírez Barreto

2010-01-01

Full Text Available This essay explores Tim Ingold’s anthropological theory following his references to Merleau-Ponty and the concept of interanimality/interagentivity. It poses some ideas of Ingold’s “poetics of dwelling”, which he highlights from ethnographies of hunter-gatherer peoples, and how these ideas are linked to an ontological consideration which does not dissociate body and person, body and mind, nature and culture, animality and humanity. The paper reviews animal literature in Merleau-Ponty’s philosophy, and Ingold’s critique of “Anthropology of the senses”. It also gives critical clues for the ethical and political implications of this ontology.

Sand flies in Timóteo, Minas Gerais, Brazil (Diptera: Psychodidae)

OpenAIRE

Andrade Filho, José Dilermando; Carneiro, Ana Paula Salgado; Lima, Mauro Lucio Nascimento; Santiago, Rodrigo Martins; Gama, Marco Antônio; Santos, Carlos Alberto; Falcão, Alda Lima; Brazil, Reginaldo Peçanha

1997-01-01

Casos esporádicos de leishmaniose tegumentar têm ocorrido no Município de Timóteo, Minas Gerais, basicamente na população rural. Para conhecer a fauna de flebotomíneos da região, foram instaladas sete armadilhas luminosas de New Jersey na cidade, em sete diferentes bairros. As coletas foram realizadas no período de junho a outubro de 1994, dezembro de 1994 e janeiro a março de 1995, com um total de 3.240 horas por armadilha. Foram capturados 4.396 flebotomíneos, distribuídos em dois gêneros e...

Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1.

Science.gov (United States)

Darwish, Noureldien H E; Sudha, Thangirala; Godugu, Kavitha; Elbaz, Osama; Abdelghaffar, Hasan A; Hassan, Emad E A; Mousa, Shaker A

2016-09-06

Acute myeloid leukemia (AML) patients show high relapse rates and some develop conventional chemotherapy resistance. Leukemia Stem Cells (LSCs) are the main player for AML relapses and drug resistance. LSCs might rely on the B-cell-specific Moloney murine leukemia virus integration site-1 (BMI-1) in promoting cellular proliferation and survival. Growth of LSCs in microenvironments that are deprived of nutrients leads to up-regulation of the signaling pathways during the progression of the disease, which may illustrate the sensitivity of LSCs to inhibitors of those signaling pathways as compared to normal cells. We analyzed the expression of LSC markers (CD34, CLL-1, TIM-3 and BMI-1) using quantitative RT-PCR in bone marrow samples of 40 AML patients of different FAB types (M1, M2, M3, M4, M5, and M7). We also studied the expression of these markers in 2 AML cell lines (Kasumi-1 and KG-1a) using flow cytometry and quantitative RT-PCR. The overexpression of TIM-3, CLL-1, and BMI-1 was markedly correlated with poor prognosis in these patients. Our in vitro findings demonstrate that targeting BMI-1, which markedly increased in the leukemic cells, was associated with marked decrease in leukemic burden. This study also presents results for blocking LSCs' surface markers CD44, CLL-1, and TIM-3. These markers may play an important role in elimination of AML. Our study indicates a correlation between the expression of markers TIM-3, CLL-1, and especially of BMI-1 and the aggressiveness of AML and thus the potential impact of prognosis and therapies that target LSCs on improving the cure rates.

Application of TIMS in isotope correlations for determining the isotope ratios of plutonium

International Nuclear Information System (INIS)

Alamelu, D.; Aggarwal, S.K.

2003-01-01

Thermal ionisation mass spectrometry (TIMS) is a well-recognized technique for determining the isotopic composition of Pu in irradiated nuclear fuel samples. Other mass spectrometric methods such as ICPMS, SIMS can also be employed for the isotopic analysis of Pu. In the event of non-availability of a mass spectrometer, other techniques such as gamma spectrometry and alpha spectrometry can also be used. They have a limited applicability since data on all the Pu isotopes cannot be obtained

Response to Tim Barringer, A White Atlantic?

Directory of Open Access Journals (Sweden)

Kate Flint

2009-11-01

Full Text Available In my response to Tim Barringer’s piece, I emphasize the importance of extending one’s frame of reference when discussing transatlantic artistic connections to the consideration of as many different art forms as possible – including photography, and magazine and book illustrations – in order to get as full a picture as possible of the two-way flow in transatlantic artistic influences.This fuller picture notably extends the degree to which images of non-white subjects are seen to be in circulation. I also draw attention to the ways in which American and English artistic circles intersected outside as well as within these two countries, a point reinforced by looking at American women sculptors in Rome in the 1860s, paying particular attention to the work of the part African-American, part Native American sculptor, Edmonia Lewis. In her work can be seen a complex set of attitudes towards her subject matter that remind one forcefully of the many racial and cultural strands coming together in new American art.

GANGGUAN CEMAS PADA MAHASISWA SEMESTER I DAN VII PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA

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Dyah Chandratika

2015-05-01

Full Text Available Penting untuk dilakukan penelitian mengenai gangguan cemas pada mahasiswa kedokteran karena tingginya tingkat stres mahasiswa terutama pada tahun pertama perkuliahan. Tujuan penelitian ini adalah untuk mengetahui prevalensi dan perbedaan skor  gangguan  cemas  pada mahasiswa  semester  I dan  VII serta untuk  mengetahui perbedaan skor gangguan cemas antara mahasiswa laki-laki dan perempuan di Fakultas Kedokteran Universitas Udayana. Desain penelitian ini adalah cross sectional analitik. Pengambilan sampel dilakukan secara random sampling. Sampel mengisi identitas, kuesioner L-MMPI, kuesioner Hamilton Anxiety Rating Scale (HARS. Kemudian dihitung prevalensi gangguan cemas tiap kelompok serta data dianalisis menggunakan uji t-independen. Terdapat 15 orang (25,0% mahasiswa semester I dan 7 orang (11,7% mahasiswa semester VII yang mengalami gangguan cemas. Dari hasil uji t-independen antara skor gangguan cemas mahasiswa semester I dan VII diperoleh nilai p = 0,001 (<0,05. Sedangkan diperoleh p = 0,080 antara mahasiswa laki-laki dan perempuan pada semester I dan p = 0,744 antara mahasiswa laki-laki dan perempuan pada semester VII. Prevalensi gangguan cemas pada mahasiswa semester I yaitu 25,0% sedangkan 11,7% pada mahasiswa semester VII. Terdapat perbedaan bermakna antara skor gangguan cemas mahasiswa semester I dan VII. Tidak ditemukan perbedaan bermakna skor gangguan cemas antara laki-laki dan perempuan.   

PERAN PEMERINTAH DAERAH DALAM PEMBERDAYAAN PEREMPUAN DI KELURAHAN KALEGOWA, KECAMATAN SOMBA OPU KABUPATEN GOWA

Directory of Open Access Journals (Sweden)

Adzimat Tinur Haque

2014-04-01

   Berbagai fenomena terkait dengan perempuan baik dalam bidang politik, ekonomi, sosial, dan budaya menciptakan perbedaan eksistensial antara laki-laki dan perempuan. Hingga melahirkan pemikiran bahwa kedudukan perempuan dan laki-laki berbeda, perempuan cenderung sebagai subordinat dalam rumah tangga. Untuk itu, dalam tulisan ini hendak melihat peran Badan Keluarga Berencana dan Pemberdayaan Perempuan dalam meningkatkan kualitas perempuan. Peneliian ini menggunakan penelitian deskriptif kualitatiff yaitu data yang dikumpulkan dideskriptifkan berdasarkan hasil wawancara langsung dan pengamatan langsung di lapangan. Peran Badan Keluarga Berencana Dan Pemberdayaan Perempuan dalam Pemberdayaan Perempuan yaitu dengan melakukan sosialisasi tentang kelompok usaha kepada peserta pemberdayaan, pendampingan mulai dari tahap persiapan, pelaksanaan hingga evaluasi, dan yang terakhir yaitu pelatihan yang didalamnya berisi pelatihan pembuatan jajanan pasar, pelatihan tas pesta dan pelatihan penjahitan, dalam kegiatan tersebut yang berfungsi sebagai pelaksana yaitu Badan Keluarga Berencana Dan Pemberdayaan Perempuan yang dibantu oleh LSM ( Lembaga Swadaya Masyarakat serta tim penggerak PKK, sedangkan yang berfungsi sebagai peserta yaitu perempuan yang akan melakukan pemberdayaan. Dengan berjalannya peran tersebut perempuan sudah bisa malakukan Akses, Kontrol, Manfaat dan Partisipasi.

AVIRIS and TIMS data processing and distribution at the land processes distributed active archive center

Science.gov (United States)

Mah, G. R.; Myers, J.

1993-01-01

The U.S. Government has initiated the Global Change Research program, a systematic study of the Earth as a complete system. NASA's contribution of the Global Change Research Program is the Earth Observing System (EOS), a series of orbital sensor platforms and an associated data processing and distribution system. The EOS Data and Information System (EOSDIS) is the archiving, production, and distribution system for data collected by the EOS space segment and uses a multilayer architecture for processing, archiving, and distributing EOS data. The first layer consists of the spacecraft ground stations and processing facilities that receive the raw data from the orbiting platforms and then separate the data by individual sensors. The second layer consists of Distributed Active Archive Centers (DAAC) that process, distribute, and archive the sensor data. The third layer consists of a user science processing network. The EOSDIS is being developed in a phased implementation. The initial phase, Version 0, is a prototype of the operational system. Version 0 activities are based upon existing systems and are designed to provide an EOSDIS-like capability for information management and distribution. An important science support task is the creation of simulated data sets for EOS instruments from precursor aircraft or satellite data. The Land Processes DAAC, at the EROS Data Center (EDC), is responsible for archiving and processing EOS precursor data from airborne instruments such as the Thermal Infrared Multispectral Scanner (TIMS), the Thematic Mapper Simulator (TMS), and Airborne Visible and Infrared Imaging Spectrometer (AVIRIS). AVIRIS, TIMS, and TMS are flown by the NASA-Ames Research Center ARC) on an ER-2. The ER-2 flies at 65000 feet and can carry up to three sensors simultaneously. Most jointly collected data sets are somewhat boresighted and roughly registered. The instrument data are being used to construct data sets that simulate the spectral and spatial

Book review: Social Research: Issues, Methods and Process, 3rd edition, by Tim May, Open University Press, 2001, ISBN 0335206123

OpenAIRE

Jones, Keith

2004-01-01

The great strength of this book by Tim May ("Social Research: Issues, Methods and Process", 3rd edition ) is its successful negotiation (perhaps navigation) of the relationships between theory and method in (social) research.

Una década de la Tarjeta de Identidad de Menores (TIM

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Eugenia Ma. Zamora Chavarría

2013-07-01

Full Text Available El documento de identidad de las personas difiere de su derecho a la identidad, propiamente dicho; uno y otro se encuentran estrechamente relacionados y el primero tiene la virtud de acreditar, de una manera inmediata y directa, frente a la comunidad, al segundo. Este artículo ofrece una serie de reflexiones alrededor del derecho al nombre y al concepto de identidad. Se centra en el documento denominado Tarjeta de Identidad para Costarricenses de Doce a Dieciocho Años, conocida popularmente como la Ley TIM y repasa lo actuado por el Tribunal en relación con este documento.

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1).

Science.gov (United States)

Ribnicky, David M; Roopchand, Diana E; Oren, Andrew; Grace, Mary; Poulev, Alexander; Lila, Mary Ann; Havenaar, Robert; Raskin, Ilya

2014-01-01

The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions. Blueberry polyphenol-rich extract was delivered to TIM-1 in the absence or presence of a high-fat meal. HPLC analysis of seventeen anthocyanins showed that delphinidin-3-glucoside, delphinidin-3-galactoside, delphinidin-3-arabinoside and petunidin-3-arabinoside were twice as bioaccessible in fed state, whilst delphinidin-3-(6″-acetoyl)-glucoside and malvidin-3-arabinoside were twice as bioaccessible under fasted conditions, suggesting lipid-rich matrices selectively effect anthocyanin bioaccessibility. TIM-1 was fed blueberry juice (BBJ) or blueberry polyphenol-enriched defatted soybean flour (BB-DSF) containing equivalent amounts of free or DSF-sorbed anthocyanins, respectively. Anthocyanin bioaccessibility from BB-DSF (36.0±10.4) was numerically, but not significantly, greater than that from BBJ (26.3±10.3). Ileal efflux samples collected after digestion of BB-DSF contained 2.8-fold more anthocyanins than same from BBJ, suggesting that protein-rich DSF protects anthocyanins during transit through upper digestive tract for subsequent colonic delivery/metabolism. Copyright © 2013 Elsevier Ltd. All rights reserved.

A TIMS-based method for the high precision measurements of the three-isotope potassium composition of small samples

DEFF Research Database (Denmark)

Wielandt, Daniel Kim Peel; Bizzarro, Martin

2011-01-01

A novel thermal ionization mass spectrometry (TIMS) method for the three-isotope analysis of K has been developed, and ion chromatographic methods for the separation of K have been adapted for the processing of small samples. The precise measurement of K-isotopes is challenged by the presence of ...

CB2 cannabinoid receptors modulate HIF-1α and TIM-3 expression in a hypoxia-ischemia mouse model.

Science.gov (United States)

Kossatz, Elk; Maldonado, Rafael; Robledo, Patricia

2016-12-01

The role of CB2 cannabinoid receptors (CB 2 R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB 2 R in the behavioural and biochemical underpinnings related to brain damage induced by HI in adult mice, and the mechanisms involved. CB 2 R knockout (KO) mice and wild-type littermates (WT) underwent permanent ligation of the left common carotid artery and hypoxia. Behavioural measurements in the rotarod, beam walking, object recognition, open field, and Irwin tests were carried out 24h, 72h and 7 days. In KO mice, more extensive brain injury was observed. Behavioural deficits in the Irwin test were observed in both genotypes; while WT mice showed progressive recovery by day 7, KO mice did not. Only KO mice showed alterations in motor learning, coordination and balance, and did not recover over time. A higher expression of microglia and astrocytes was observed in several brain areas of lesioned WT and KO mice. The possible alteration of the inflammatory-related factors HIF-1α and TIM-3 was evaluated in these animals. In both genotypes, HIF-1α and TIM-3 expression was observed in lesioned areas associated with activated microglia. However, the expression levels of these proteins were exacerbated in KO mice in several lesioned and non-lesioned brain structures. Our results indicate that CB 2 R may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1α/TIM-3 signalling pathway in microglia. Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

On the Use of 233U-236U Double-Spike for TIMS Measurements of Uranium Isotopes: A Simulation Study

International Nuclear Information System (INIS)

Williams, R W

2004-01-01

Synthetic ion beams with instantaneous and temporal characteristics appropriate to thermal ionization mass spectrometry (TIMS) were mathematically generated and analyzed to determine the effects of using a mixed 233 U- 236 U spike (double-spike) in the analysis of uranium isotopes. The instantaneous beam characteristics are the intensities (e.g., counts per second) modeled with a Poisson distribution plus a component of random noise that simulates the detection processes. Several beam intensity and mass fractionation vs. time functions were modeled to simulate a range of sample sizes and the commonly employed methods of data collection. These beam profiles were also generated with different noise levels, and signal-to-noise vs. analytical precision diagrams are presented. Modeling focused on natural uranium, where 238 U/ 235 U = 137.88, and on the ability of a given method to determine precisely and accurately small variations in this ratio. Practical limits on precision were determined to be 20-30 ppm, which is consistent with precision seen for other elements by state-of-the-art TIMS. The TIMS total evaporation method was compared directly with the double-spike method. While similar analytical precisions are obtained with either method, the double-spike method of correcting for analytical bias gives more accurate results. The results of a total evaporation analysis will deviate from true by more than the analytical precision if as little as 0.05% of the signal is not integrated, whereas the accuracy and precision of the double-spiked analyses are always linked

BENTUK KECURANGAN AKADEMIK (ACADEMIC CHEATING MAHASISWA PGMI FAKULTAS TARBIYAH DAN KEGURUAN UIN ALAUDDIN MAKASSAR

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Nursalam Nursalam

2013-12-01

Full Text Available Abstrak: Penelitian ini bertujuan untuk mengetahui bentuk-bentuk kecurangan akademik (academic cheating mahasiswa PGMI Fakultas Tarbiyah dan Keguruan UIN Alauddin Makassar. Hasil penelitian menunjukkan bahwa bentuk-bentuk kecu-rangan akademik yang dilakukan oleh mahasiswa PGMI adalah menyontek pe-kerjaan teman pada saat ujian, membuka buku saat ujian, menyalin tugas teman, membuka internet melalui handphone, copy paste dari internet. Faktor-faktor yang menyebabkan mahasiswa melakukan kecurangan akademik adalah sangat sulit mengerjakan tugas yang diberikan oleh dosen membutuhkan jawaban yang real, mahasiswa terpengaruh dengan adanya mahasiswa lain yang menyontek, soal yang diberikan oleh dosen terlalu sulit, waktu yang disediakan sangat singkat, mahasiswa tidak memahami materi yang diujikan, ragu dengan jawaban sendiri, tidak ada hukuman yang diberikan jika berbuat curang, mendapatkan nilai yang bagus. Abstract: This study aims to determine the forms of academic cheatings of the students of Madrasah Ibtidaiyah Teacher Education Program at Tarbiyah and Teacher Training Faculty of UIN Alauddin Makassar. The results showed that the forms of academic cheating committed by the students while doing the exam are copying their friends’ work, opening book, copying friend’ task, open the internet via mobile phones, and doing copy-paste from the internet. The factors that lead to student academic cheating is the task given by the lecturers is very difficult and it needs text-book answers, the students affected by the presence of other students who cheat, questions given by the lecturers were too difficult, the time provided in the exam is very short, the students do not understand the material tested, they are unsure with their own answers, no penalty is given for cheating, and even the cheaters get good grades.

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.

Science.gov (United States)

Linedale, Richard; Schmidt, Campbell; King, Brigid T; Ganko, Annabelle G; Simpson, Fiona; Panizza, Benedict J; Leggatt, Graham R

2017-01-01

Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.

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Richard Linedale

Full Text Available Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.

Analisa Beban Kerja Dengan Menggunakan Work Sampling Dan Nasa-tlx Untuk Menentukan Jumlah Operator (Studi Kasus: PT Xyz)

OpenAIRE

Ramadhan, Rahadian; Tama, Ishardita Pambudi; Efranto, Remba Yanuar

2014-01-01

PT. XYZ merupakan pabrik yang bergerak di bidang sandang. Dalam penelitian ini, metode yang digunakan adalah pengukuran beban secara fisik dan pengukuran beban secara mental. Pada PT XYZ para pelaksana mesin sering sekali mengeluh tentang kelelahan karena harus mengoperasikan mesin yang banyak dalam sekali kerja. Untuk mengurangi kelelahan tersebut maka dibuatlah rencana penambahan jumlah karyawan tetap untuk mengurangi beban kerja setiap pelaksana mesin.. Pengukuran beban kerja menggunakan m...

Coordinated Traffic Incident and Congestion Management (TIM-CM) : Mitigating Regional Impacts of Major Traffic Incidents in the Seattle I-5 Corridor

Science.gov (United States)

2018-02-02

Within the Seattle metropolitan area, traffic incident management (TIM) operations provide a multi-jurisdictional and coordinated strategy to detect, respond to, and clear traffic incidents so that traffic flow can be restored quickly and safely. The...

Dr TIM: Ray-tracer TIM, with additional specialist scientific capabilities

Science.gov (United States)

Oxburgh, Stephen; Tyc, Tomáš; Courtial, Johannes

2014-03-01

We describe several extensions to TIM, a raytracing program for ray-optics research. These include relativistic raytracing; simulation of the external appearance of Eaton lenses, Luneburg lenses and generalised focusing gradient-index lens (GGRIN) lenses, which are types of perfect imaging devices; raytracing through interfaces between spaces with different optical metrics; and refraction with generalised confocal lenslet arrays, which are particularly versatile METATOYs. Catalogue identifier: AEKY_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKY_v2_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licencing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 106905 No. of bytes in distributed program, including test data, etc.: 6327715 Distribution format: tar.gz Programming language: Java. Computer: Any computer capable of running the Java Virtual Machine (JVM) 1.6. Operating system: Any, developed under Mac OS X Version 10.6 and 10.8.3. RAM: Typically 130 MB (interactive version running under Mac OS X Version 10.8.3) Classification: 14, 18. Catalogue identifier of previous version: AEKY_v1_0 Journal reference of previous version: Comput. Phys. Comm. 183(2012)711 External routines: JAMA [1] (source code included) Does the new version supersede the previous version?: Yes Nature of problem: Visualisation of scenes that include scene objects that create wave-optically forbidden light-ray fields. Solution method: Ray tracing. Reasons for new version: Significant extension of the capabilities (see Summary of revisions), as demanded by our research. Summary of revisions: Added capabilities include the simulation of different types of camera moving at relativistic speeds relative to the scene; visualisation of the external appearance of generalised focusing gradient-index (GGRIN) lenses, including Maxwell fisheye, Eaton and Luneburg lenses; calculation of

W3C director Tim Berners-Lee to be Knighted by Queen Elizabeth web inventor recognized for contributions to internet development

CERN Document Server

2003-01-01

"Tim Berners-Lee, the inventor of the World Wide Web and director of the World Wide Web Consortium (W3C), will be made a Knight Commander, Order of the British Empire (KBE) by Queen Elizabeth" (1/2 page).

High-Resolution Zircon U-Pb CA-TIMS Dating of the Carboniferous—Permian Successions, Paraná Basin, Brazil

Science.gov (United States)

Griffis, N. P.; Mundil, R.; Montanez, I. P.; Isbell, J.; Fedorchuk, N.; Lopes, R.; Vesely, F.; Iannuzzi, R.

2015-12-01

The late Paleozoic Ice Age (LPIA) is Earth's only record of a CO2-forced climatic transition from an icehouse to greenhouse state in a vegetated world. Despite a refined framework of Gondwanan ice distribution, questions remain about the timing, volume, and synchronicity of high-latitude continental ice and the subsequent deglaciation. These questions ultimately preclude our understanding of linkages between ice volume, sea level, and high- and low-latitude climate. Poor constraints on the timing and synchronicity of glacial and interglacial transitions reflect a lack of high-resolution radioisotopic dates from high-latitude, ice-proximal Carboniferous-Permian successions. The Rio Bonito Fm in Rio Grande do Sul State of southern Brazil hosts the oldest non-glaciogenic Carboniferous- Permian deposits of the Paraná Basin, thus recording the icehouse-to-greenhouse transition. Despite a widespread effort over the last two decades to constrain these deposits in time by means of U-Pb zircon geochronology, published data sets of the Candiota and Faxinal coals of the Rio Bonito Fm host discrepancies that may reflect post- eruptive open system behavior of zircon and analytical artifacts. These discrepancies have hindered the correlation of the Candiota and Faxinal sediments within the larger Gondwanan framework. Here we present the first U-Pb ages on closed system single zircons using CA-TIMS techniques on Permo-Carboniferous ash deposits of the Paraná Basin. Preliminary results indicate two major and distinct coal-forming periods that are separated by ca 10 Ma. Our results and conclusions are not in agreement with multi- crystal U-Pb TIMS and SIMS ages that suggest coeval deposition of the Candiota and Faxinal coals. CA-TIMS analyses applied to zircons from additional ash deposits are aimed at constructing a robust chronostratigraphic framework for the Carboniferous- Permian succession of the Paraná Basin, which will facilitate a better understanding of the timing and

TIMS analysis of Sr and Nd isotopes in melt inclusions from Italian potassium-rich lavas using prototype 1013Ω amplifiers

NARCIS (Netherlands)

Koornneef, Janne M.; Nikogosian, Igor; van Bergen, Manfred J.; Smeets, Richard; Bouman, Claudia; Davies, Gareth R.

2015-01-01

Sr and Nd isotopes were determined using new thermal ionisation mass spectrometry (TIMS) techniques for a suite of 21 olivine-hosted (85-92mol% Fo) melt inclusions selected from potassic and ultra-potassic lavas from the Italian peninsula. Sr isotopes were measured using default 1011Ω resistors,

Use of 1012 ohm current amplifiers in Sr and Nd isotope analyses by TIMS for application to sub-nanogram samples

NARCIS (Netherlands)

Koornneef, J.M.; Bouman, C.; Schwieters, J.B.; Davies, G.R.

2013-01-01

We have investigated the use of current amplifiers equipped with 10 12 ohm feedback resistors in thermal ionisation mass spectrometry (TIMS) analyses of sub-nanogram sample aliquots for Nd and Sr isotope ratios. The results of analyses using the 1012 ohm resistors were compared to those obtained

Flebotomíneos de Timóteo, Estado de Minas Gerais, Brasil (Diptera: Psychodidae Sand flies in Timóteo, Minas Gerais, Brazil (Diptera: Psychodidae

Directory of Open Access Journals (Sweden)

José Dilermando Andrade Filho

1997-10-01

Full Text Available Casos esporádicos de leishmaniose tegumentar têm ocorrido no Município de Timóteo, Minas Gerais, basicamente na população rural. Para conhecer a fauna de flebotomíneos da região, foram instaladas sete armadilhas luminosas de New Jersey na cidade, em sete diferentes bairros. As coletas foram realizadas no período de junho a outubro de 1994, dezembro de 1994 e janeiro a março de 1995, com um total de 3.240 horas por armadilha. Foram capturados 4.396 flebotomíneos, distribuídos em dois gêneros e vinte espécies: Brumptomyia cunhai, Brumptomyia nitzulescui, Lutzomyia (Nyssomyia whitmani, Lutzomyia (Nyssomyia intermedia, Lutzomyia quinquefer, Lutzomyia lenti, Lutzomyia (Pintomyia fischeri, Lutzomyia migonei, Lutzomyia sallesi, Lutzomyia termitophila, Lutzomyia aragaoi, Lutzomyia borgmeieri, Lutzomyia (Psathyromyia lutziana, Lutzomyia (Sciopemyia sordellii, Lutzomyia (Pintomyia pessoai, Lutzomyia (Trichopygomyia longispina, Lutzomyia misionensis, Lutzomyia (Psychodopygus davisi, Lutzomyia lanei, Lutzomyia (Pressatia sp. A espécie L. (N. whitmani foi a mais freqüente com 52,12%, seguida de L. (N. intermedia com 34,10%, e ambas podem estar participando da transmissão de leishmaniose cutânea na região.Sporadic cases of tegumentary leishmaniasis have occurred in Timóteo, Minas Gerais State, basically among the rural population. In order to study the region's sand fly population, New Jersey light traps were set in seven different neighborhoods. Specimens were gathered from June through October 1994, December 1994, and January through March 1995, with a total of 3,240 hours per trap. A total of 4,396 sand flies were captured, distributed among two genera and twenty species: Brumptomyia cunhai, Brumptomyia nitzulescui, Lutzomyia (Nyssomyia whitmani, Lutzomyia (Nyssomyia intermedia, Lutzomyia quinquefer, Lutzomyia lenti, Lutzomyia (Pintomyia fischeri, Lutzomyia migonei, Lutzomyia sallesi, Lutzomyia termitophila, Lutzomyia aragaoi, Lutzomyia

New sequential separation procedure for Sr, Nd and Pb isotope ratio measurement in geological material using MC-ICP-MS and TIMS

Digital Repository Service at National Institute of Oceanography (India)

Makishima, A.; Nath, B.N.; Nakamura, E.

A new 3-step sequential separation chemistry for Sr, Nd and Pb from silicate samples, which is suitable for isotope analysis by MC-ICP-MS as well as TIMS, has been developed. The chemistry is designed to minimize the number of evaporation steps...

EVALUASI PEMANFAATAN JURNAL DALAM DATABASE "EBSCO BIOMEDICAL REFERENCE COLLECTION" DI UNIT PERPUSTAKAAN DAN INFORMATIKA KEDOKTERAN (UPIK FAKULTAS KEDOKTERAN UGM YOGYAKARTA

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Eka Wardhani S.

2015-12-01

Full Text Available Evaluasi terhadap pemanfaatan koleksi sangat diperlukan untuk mengetahui seberapa besar koleksi tersebut diakses dan dimanfaatkan oleh pengguna. Ebsco Biomedical Reference Collection (Ebsco BRC merupakan salah satu database jurnal yang berparadigma akses. Evaluasi pemanfaatan jurnal dalam database Ebsco BRC merupakan penelitian tentang pemanfaatan koleksi perpustakaan yang dilakukan di UPIK (Unit Perpustakaan dan Informatika Kedokteran Fakultas Kedokteran Universitas Gadjah Mada Yogyakarta. Penelitian ini bertujuan untuk mengetahui tingkat keterpakaian dan pemanfaatan jumal oleh sivitas akademika di FK UGM. Evaluasi dilakukan dengan metode deskriptif dengan pendekatan data kuantitatif dan kualitatif. . Instrumen yang digunakan dalam evaluasi adalah kuesioner dan usage statistics report. Hasil Penelitian ini menunjukkan bahwa tingkat keterpakaian jurnal berdasarkan judul yang ada tinggi (97,96%, akan tetapi tingkat pengaksesannya belum dilakukan secara maksimal. Rata-rata pengaksesan jurnal setiap harinya 25%. Dari data usage statistics report dapat diketahui sebanyak 12 judul jumal yang diakses lebih dari 1000 kali yang dinyatakan sebagai jumal yang paling sering diakses oleh pengguna. Saran peneliti berdasarkan hasil penelitian yang diperoleh adalah bahwa kegiatan melanggan koleksi database Ebsco dapat terus dilakukan , akan tetapi UPIK harus berusaha meningkatkan sosialisasi koleksi, aksesibilitas, fasilitas, dan bimbingan bagi pengguna dalam melakukan penelusuran dalam database tersebut agar dapat dimanfaatkan secara maksimal. Kata Kunci: Evaluasi Koleksi, Ebsco

DIFERENCE EFFICACY BETWEEN WINNER AND DEFEAT TIM ON WORLD CHAMPIONSHIP IN SOCCER GAME 2006

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Alen Kapidžić

2007-04-01

Full Text Available We analyse thirty games of world championship in soccer 2006 with am to determine variables which contribute signifi cant distinction and differences between winner and defeat tim. Fortifi cation differences in aplayed variables we will apply multivariant analisis of variance. For this examination we will use variable of tehnich elements, and some of tactics calculation and estimate quality of tehnics elements according to the judges. This problem is very interesting for exploration, and it’s leading to modern tendency’s so these are the elementary reasons why we chose this kind of exploration.

A field- and laboratory-based quantitative analysis of alluvium: Relating analytical results to TIMS data

Science.gov (United States)

Wenrich, Melissa L.; Hamilton, Victoria E.; Christensen, Philip R.

1995-01-01

Thermal Infrared Multispectral Scanner (TIMS) data were acquired over the McDowell Mountains northeast of Scottsdale, Arizona during August 1994. The raw data were processed to emphasize lithologic differences using a decorrelation stretch and assigning bands 5, 3, and 1 to red, green, and blue, respectively. Processed data of alluvium flanking the mountains exhibit moderate color variation. The objective of this study was to determine, using a quantitative approach, what environmental variable(s), in the absence of bedrock, is/are responsible for influencing the spectral properties of the desert alluvial surface.

FAKTOR-FAKTOR YANG MEMENGARUHI PERILAKU PRODUKTIF MAHASISWA FAKULTAS EKONOMI ANGKATAN TAHUN 2013

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Rheza Hafid Prastia

2017-02-01

Full Text Available Education is an important element for undergraduate students to encourage a positive economic attitude. Basically, undergraduate students are not being a consumer only, but also are expected to be able to serve as a producer by processing a resources arround themselves maximally. Within this research, likert scale questionnaire is used as an instrument and tested in terms of validity and reliability in undergraduate students of Faculty of Economics Universitas Negeri Malang 2013. The sample of this study was 304 undergraduate students. The data analysis was conducted using SEM technique through Lisrel 8.80 program. The results indicated that economic education in the family has no influence upon the self-efficacy. Moreover, financial literacy does not influence to the self-efficacy and economic rationality influences self-efficacy. In addition, self-efficacy influences productive attitude of the students, economic education in family influences productive attitude of the students. However, economic education in family does not influence productive attitude through self-efficacy as well as financial literasi which does not influence productive attitude through self-efficacy. While economic rationality influneces productive attitude through self-efficacy. Pentingnya pendidikan yang diberikan kepada seorang mahasiswa adalah untuk mendorong munculnya perilaku yang baik dalam hal ekonomi. Pada dasarnya setiap mahasiswa tidak hanya berperan sebagai konsumen saja, melainkan juga bertindak sebagai produsen yang berperilaku produktif dengan cara mampu mengolah sumber daya yang ada di sekitarnya untuk dimanfaatkan secara maksimal. Sebelum penelitian, angket yang digunakan sebagai instrumen penelitian dengan skala likert terlebih dahulu di uji validitas dan reliabilitasnya pada mahasiswa Fakultas Ekonomi Universitas Negeri Malang angkatan 2013. Sebanyak 304 mahasiswa menjadi sampel dalam penelitian dan menggunakan teknik analisis SEM dengan bantuan program

Comparison of Nitrogen Bioaccessibility from Salmon and Whey Protein Hydrolysates using a Human Gastrointestinal Model (TIM-1

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Bomi Framroze

2014-05-01

Full Text Available Background: The TIM-1 system is a computer-controlled multi-compartmental dynamic model that closely simulates in vivo gastrointestinal tract digestion in humans. During digestion, the compounds released from meal matrix by gastric and intestinal secretions (enzymes are progressively absorbed through semipermeable membranes depending on their molecular weight. These absorbed (dialysed compounds are considered as bioaccessible, which means that they can be theoretically absorbed by the small intestine in the body. Methods: Salmon protein hydrolysate (SPH, whey protein hydrolysates extensively (WPHHigh or weakly (WPH-Low hydrolysed, non-hydrolysed whey protein isolate (WPI and mixtures of WPI:SPH (90:10, 80:20 were digested in TIM-1 using the conditions for a fast gastrointestinal transit that simulate the digestion of a liquid meal in human adults. During digestion (2 hours, samples were collected in intestinal compartments (duodenum, jejunum, and ileum and in both jejunal and ileal dialysates to determine their nitrogen content. All the products were compared in terms of kinetics of nitrogen absorption through the semipermeable membranes (bioaccessible nitrogen and nitrogen distribution throughout the intestinal compartments at the end of the 2 hour digestion. Results: After a 2 h-digestion in TIM-1, SPH was the protein substrate from which the highest amount of nitrogen (67.0% becomes available for the small intestine absorption. WPH-High had the second highest amount (56.0% of bioaccessible nitrogen while this amount decreased to 38.5–42.2% for the other protein substrates. The high nitrogen bioaccessibility of SPH is consistent with its richness in low molecular weight peptides (50% < 1000 Da. Conclusions: The results of this study indicate that SPH provides a higher proportion of bioaccessible nitrogen to a healthy adult compared to all forms of whey proteins, including extensively hydrolysed whey protein hydrolysate. The substitution of

Determination of isotopic composition of boron in boron carbide by TIMS and PIGE: an inter-comparison study

International Nuclear Information System (INIS)

Sasibhushan, K.; Rao, R.M.; Parab, A.R.; Alamelu, D.; Aggarwal, S.K.; Acharya, R.; Chhillar, S.; Pujari, P.K.

2015-01-01

The paper reports a comparison of results on the determination of isotopic composition of boron in boron carbide (B 4 C) samples by Thermal Ionisation Mass Spectrometry (TIMS) and Particle Induced Gamma ray Spectrometry (PIGE). B 4 C samples having varying boron isotopic composition (natural, enriched with respect to 10 B) and their synthetic mixtures) have been analysed by both the techniques. The 10 B atom% was found to be in the range of 20-67%. (author)

Sensor 17 Thermal Isolation Mounting Structure (TIMS) Design Improvements

Energy Technology Data Exchange (ETDEWEB)

Enstrom, K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2015-09-04

The SENSOR 17 thermographic camera weighs approximately 0.5lbs, has a fundamental mode of 167 Hz, and experiences 0.75W of heat leakage in through the TIMS. The configuration, shown in Figure 1, is comprised of four 300 Series SST washers paired in tandem with P.E.I (Ultem 100) washers. The SENSOR 17 sensor is mounted to a 300 series stainless plate with A-shaped arms. The Plate can be assumed to be at ambient temperatures (≈293K) and the I.R. Mount needs to be cooled to 45K. It is attached to the tip of a cryocooler by a ‘cold strap’ and is assumed to be at the temperature of the cold-strap (≈45K). During flights SENSOR 17 experiences excitations at frequencies centered around 10-30Hz, 60Hz, and 120Hz from the aircraft flight environment. The temporal progression described below depicts the 1st Modal shape at the systems resonant frequency. This simulation indicates Modal articulation will cause a pitch rate of the camera with respect to the body axis of the airplane. This articulation shows up as flutter in the camera.

Pb isotope analysis of ng size samples by TIMS equipped with a 1013 Ω resistor using a 207Pb-204Pb double spike

NARCIS (Netherlands)

Klaver, M.; Smeets, R.J.; Koornneef, J.M.; Davies, G.R.; Vroon, P.Z.

2016-01-01

The use of the double spike technique to correct for instrumental mass fractionation has yielded high precision results for lead isotope measurements by thermal ionisation mass spectrometry (TIMS), but the applicability to ng size Pb samples is hampered by the small size of the

SEM/TIMS analysis trials on hotswipe samples taken from a shielded cell at Harwell

International Nuclear Information System (INIS)

Tushingham, J.; Vatter, I.; Cooke, R.

1998-09-01

The IAEA require advanced techniques and procedures for the detection of traces of actinides to be applied to their environmental sampling programme for nuclear safeguards as a means to detect undeclared activities. 'Swipe' samples taken from within nuclear facilities by IAEA inspectors require analysis to determine their actinide content and composition by bulk and particle measurements. The use of analytical equipment capable of analysing individual particles, particularly of actinides, is essential to optimise the IAEA's aim to monitor Member State's nuclear activities more proficiently. A trial has been undertaken at the Harwell Laboratory of AEA Technology to establish the efficacy of scanning electron microscopy (SEM) and thermal ionisation mass spectrometry (TIMS) for the particle and bulk characterisation, respectively, of actinides on samples taken from within a shielded cell. These measurements were supported by γ-spectrometry and α-spectrometry. 'Hotswipe' samples taken from within a shielded cell with a well-known recent history have been prepared for particle and bulk analysis. SEM has been used to characterise individual particles from the swipe samples and the results have been related to known cell activities. Samples were prepared for SEM using a simple procedure to minimise the potential for sample contamination. The method proved to be capable of identifying 1 μm particles that contained U, Pu, Pa and Np. The measurement of U/Pu ratios was limited to particles that contained >2% Pu in U by weight. TIMS, together with alpha spectrometry, has been used to determine the bulk actinide composition of the samples whilst gamma spectrometry has been used to determine the fission product composition. Further work to improve the potential of SEM, and also secondary ionisation mass spectrometry (SIMS), for the measurement of hotswipe samples has been proposed. (author)

Towards unsupervised polyaromatic hydrocarbons structural assignment from SA-TIMS-FTMS data.

Science.gov (United States)

Benigni, Paolo; Marin, Rebecca; Fernandez-Lima, Francisco

2015-10-01

With the advent of high resolution ion mobility analyzers and their coupling to ultrahigh resolution mass spectrometers, there is a need to further develop a theoretical workflow capable of correlating experimental accurate mass and mobility measurements with tridimensional candidate structures. In the present work, a general workflow is described for unsupervised tridimensional structural assignment based on accurate mass measurements, mobility measurements, in silico 2D-3D structure generation, and theoretical mobility calculations. In particular, the potential of this workflow will be shown for the analysis of polyaromatic hydrocarbons from Coal Tar SRM 1597a using selected accumulation - trapped ion mobility spectrometry (SA-TIMS) coupled to Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). The proposed workflow can be adapted to different IMS scenarios, can utilize different collisional cross-section calculators and has the potential to include MS n and IMS n measurements for faster and more accurate tridimensional structural assignment.

Second NASA Technical Interchange Meeting (TIM): Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box (TTB)

Science.gov (United States)

ONeil, D. A.; Mankins, J. C.; Christensen, C. B.; Gresham, E. C.

2005-01-01

The Advanced Technology Lifecycle Analysis System (ATLAS), a spreadsheet analysis tool suite, applies parametric equations for sizing and lifecycle cost estimation. Performance, operation, and programmatic data used by the equations come from a Technology Tool Box (TTB) database. In this second TTB Technical Interchange Meeting (TIM), technologists, system model developers, and architecture analysts discussed methods for modeling technology decisions in spreadsheet models, identified specific technology parameters, and defined detailed development requirements. This Conference Publication captures the consensus of the discussions and provides narrative explanations of the tool suite, the database, and applications of ATLAS within NASA s changing environment.

Analisa Beban Kerja Fisik dan Mental dengan Menggunakan Work Sampling dan NASA-TLX Untuk Menentukan Jumlah Operator

Directory of Open Access Journals (Sweden)

Anton Maretno

2015-04-01

Full Text Available Perbedaan sistem kerja yang ada di antara operator Quality Control dan operator produksi pada divisi Particle Board menyebabkan adanya perbedaan nilai beban kerja. Hal tersebut dapat dilihat dari perbedaan jumlah jam lembur pada kedua bagian tersebut dimana jumlah jam lembur pada operator Quality Control lebih besar. Penelitian ini bertujuan untuk menganalisa beban kerja operator Quality Control serta menganalisa jumlah operator yang optimal untuk menyelesaikan pekerjaan Quality Control.Penelitian ini menggunakan metode pengukuran beban kerja fisik (Work sampling dan pengukuran beban kerja Mental NASA - Task Load Index (NASA-TLX. Menurut perhitungan beban kerja fisik dan mental, pelaksana yang memiliki load paling tinggi adalah pekerjaanQuality Control ( QC Finish board (108.1%, sedangkan terendah ada pada pekerjaan Quality Control ( QC Produk (72.3%. Setelah penambahan pelaksana  Quality Control ( QC Finish board sebanyak 1 orang, beban kerja fisik untuk pekerjaanQuality Control ( QC Finish board menjadi 71.1%. Sedangkan untuk pekerjaan Quality Control yang lain tidak membutuhkan tambahan operator karena bisa memanfaatkan waktu idle yang dimiliki pelaksana Quality Control ( QC Produk untuk membantu pekerjaan lain

Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer.

Science.gov (United States)

Gao, Jianwei; Qiu, Xiangyu; Li, Xinying; Fan, Hang; Zhang, Fang; Lv, Tangfeng; Song, Yong

2018-04-06

Exosomes are membrane-bound, virus-sized vesicles present in circulating blood. Tumor cells are avid producers of exosomes, which are thought to mimic molecular features of parent tumor cells. T-cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) is a the next-generation immune checkpoint that can be activated by its ligand Galectin-9 to negatively regulate the anti-tumor immune response. However, the characteristics of plasma exosomal Tim-3 and Galectin-9 (Exo-T/G) in cancer remained unknown. This study was conducted to investigate the expression patterns and clinical value of plasma exosomal total protein (Exo-pro) and Exo-T/G in non-small cell lung cancer (NSCLC). Plasma was collected from 103 NSCLC patients including 60 early stages and 43 advanced stages disease samples as well as 56 healthy subjects. Exosomes were isolated from plasma by commercial exosome precipitation solution and identified by western blotting of CD63 and transmission electron microscopy. Exo-pro concentration was measured by the BCA assay. Enzyme-linked immunosorbent assay was used to quantify Exo-T/G. Additionally, 34 NSCLC samples were applied to directly detect plasma TIM-3 (Plas-T) and Galectin-9 (Plas-G). Our results showed that Exo-pro, Exo-T, and Exo-G were significantly increased in NSCLC plasma compared to that in the healthy samples. High levels of Exo-T and Exo-G were all positively correlated with several malignant parameters, including larger tumor size, advanced stages, and more distant metastasis. High levels of Exo-pro and Exo-T were also correlated with more lymph node metastasis. Additionally, plasma from lung squamous cell carcinoma showed higher Exo-T and Exo-G compared with that from lung adenocarcinoma. ALK-positive patients showed to have decreased Exo-T and Exo-G levels. Pearson's correlation analysis revealed a significant correlation between Exo-pro and Exo-T/G, Exo-T and Exo-G, Exo-T and Plas-T, Exo-G and Plas-G, and Plas-T and Plas-G. Together

Mini-DIAL system measurements coupled with multivariate data analysis to identify TIC and TIM simulants: preliminary absorption database analysis

International Nuclear Information System (INIS)

Gaudio, P; Malizia, A; Gelfusa, M; Poggi, L.A.; Martinelli, E.; Di Natale, C.; Bellecci, C.

2017-01-01

Nowadays Toxic Industrial Components (TICs) and Toxic Industrial Materials (TIMs) are one of the most dangerous and diffuse vehicle of contamination in urban and industrial areas. The academic world together with the industrial and military one are working on innovative solutions to monitor the diffusion in atmosphere of such pollutants. In this phase the most common commercial sensors are based on “point detection” technology but it is clear that such instruments cannot satisfy the needs of the smart cities. The new challenge is developing stand-off systems to continuously monitor the atmosphere. Quantum Electronics and Plasma Physics (QEP) research group has a long experience in laser system development and has built two demonstrators based on DIAL (Differential Absorption of Light) technology could be able to identify chemical agents in atmosphere. In this work the authors will present one of those DIAL system, the miniaturized one, together with the preliminary results of an experimental campaign conducted on TICs and TIMs simulants in cell with aim of use the absorption database for the further atmospheric an analysis using the same DIAL system. The experimental results are analysed with standard multivariate data analysis technique as Principal Component Analysis (PCA) to develop a classification model aimed at identifying organic chemical compound in atmosphere. The preliminary results of absorption coefficients of some chemical compound are shown together pre PCA analysis. (paper)

Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex.

Science.gov (United States)

Popov-Čeleketić, Dušan; Waegemann, Karin; Mapa, Koyeli; Neupert, Walter; Mokranjac, Dejana

2011-06-01

The TIM23 complex mediates translocation of proteins across, and their lateral insertion into, the mitochondrial inner membrane. Translocation of proteins requires both the membrane-embedded core of the complex and its ATP-dependent import motor. Insertion of some proteins, however, occurs in the absence of ATP, questioning the need for the import motor during lateral insertion. We show here that the import motor associates with laterally inserted proteins even when its ATPase activity is not required. Furthermore, our results suggest a role for the import motor in lateral insertion. Thus, the import motor is involved in ATP-dependent translocation and ATP-independent lateral insertion.

The particle analysis based on FT-TIMS technique for swipe sample under the frame of nuclear safeguard

International Nuclear Information System (INIS)

Yang Tianli; Liu Xuemei; Liu Zhao; Tang Lei; Long Kaiming

2008-06-01

Under the frame of nuclear safeguard, the particles analysis for swipe sample is an advance mean to detect the undeclared uranium enriched facilities and undeclared uranium enriched activity. The technique of particle analysis based on fission track-thermal ionization mass spectrometry (FT-TIMS) for swipe sample have been built. The reliability and the experimental background for selecting particles consisting of uranium from swipe sample by FT method have been verified. In addition, the utilization coefficient of particles on the surface of swipe sample have also been tested. These works have provided the technique support for application in the area of nuclear verification. (authors)

PERANCANGAN PENGEMBANGAN DIGITAL LIBRARY BERBASIS WEB RESPONSIVE

Directory of Open Access Journals (Sweden)

Tri Listyorini

2015-04-01

Full Text Available ABSTRAK E-book merupakan cara praktis untuk membaca sebuah buku. E-book bisa kita akses melalui laptop, komputer, maupun smartphone. Dalam penelitian kali ini Digital Library mengambil studi kasus pada Fakultas teknik merupakan salah satu fakultas yang ada di Universitas Muria Kudus yang ingin menjembatani dosen dan mahasiswa agar tidak bingung untuk mencari referensi buku yang dicari. Oleh karena itu Digital Library sangat dibutuhkan. Konsep Digital Library yang akan dibuat ini adalah berisi E-book dari bidang ilmu dari fakultas teknik. Dan agar dapat diakses menggunakan bermacam-macam gadget, maka Digital Library ini akan dikembangkan dengan konsep web Responsif. Dengan metode web Responsif ini tampilan dari Digital Library dapat menyesuaikan gadget yang digunakan dan mudah di akses oleh semua kalangan khususnya di fakultas teknik Universitas Muria Kudus. Hasil yang diharapkan dalam penelitian ini adalah sebuah Digital Library berbasis web Responsif, yang dapat digunakan untuk memberikan kemudahan dalam memperoleh E-book, jurnal dan sebagainya. Kata kunci: E-book, web responsif, digital library.

The Fiction of Tim Winton: Relational Ecology in an Unsettled Land

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Lyn McCredden

2017-11-01

Full Text Available Complicating the processes of belonging in place, for non-Indigenous Australians, is the growing realization that they live in a huge, diverse land, a place in which they are not native. The fiction of popular Anglo-Saxon Australian novelist Tim Winton echoes the understanding of poet Judith Wright, for whom “two strands – the love of the land we have invaded and the guilt of the invasion – have become part of me. It is a haunted country” (Wright 1991: 30. This essay will explore Winton’s novels in which there is a pervasive sense of unease and loss experienced by the central characters, in relation to place and land. Winton’s characters – Queenie Cookson and her traumatic witnessing of the barbaric capture and flaying of whales; Fish Lamb’s near-drowning in the sea, and Lu Fox’s quest for refuge in the wilderness, prophet-like, after the tragedy of his family’s death – are all written with a haunting sense of white unsettlement and displacement, where such natural forces – the sea and its creatures, the land’s distances and risks – confront and re-form the would-be dominators.

Tim Burton lavastab Batmani muusikali. Placido Domingo palkas "Star Warsi" võluri. MTV muusikaauhindade show'l narriti Michael Jacksonit. Hendrixi põlenud kitarr läheb müüki

Index Scriptorium Estoniae

2002-01-01

Jim Steinman kirjutab muusikat Tim Burtoni 2005. aastal lavale tulevale Batmani muusikalile. Los Angelese ooperimaja juht Domingo palkas George Lucase Wagneri ooperi "Nibelungide sõrmus" eriefektide ettevalmistamiseks. Britney Spears nimetas Michael Jacksonit Millenniumi artistiks.

Digestion of cooked meat proteins is slightly affected by age as assessed using the dynamic gastrointestinal TIM model and mass spectrometry.

Science.gov (United States)

Denis, S; Sayd, T; Georges, A; Chambon, C; Chalancon, S; Santé-Lhoutellier, V; Blanquet-Diot, S

2016-06-15

In humans, meat ensures the supply of proteins with high nutritional value and indispensable amino acids. The main goal of the present study was to compare the degradation of meat proteins in adult and elderly digestive conditions. Cooked meat was subjected to in vitro digestion in the dynamic multi-compartmental TIM (TNO gastroIntestinal Model) system. Digestibility and bioaccessibility were determined using nitrogen balance and digestion products were identified using mass spectrometry. The TIM model was adapted according to in vivo data to mimic the specific digestive conditions of elderly people. Meat protein digestibility and bioaccessibility were around 96 and 60% respectively and were not influenced by age (P > 0.05). As much as 800 peptides were identified in the duodenal and jejunal compartments issued from 50 meat proteins with a percentage of coverage varying from 13 to 69%. Six proteins, mainly from the cytosol, were differentially hydrolyzed under the adult and elderly digestive conditions. Pyruvate kinase was the only protein clearly showing a delay in its degradation under elderly digestive conditions. This study provides significant insights into the understanding of meat protein dynamic digestion. Such data will be helpful to design in vivo studies aiming to evaluate dietary strategies that can attenuate muscle mass loss and more generally maintain a better quality of life in the elderly population.

Thermal ionization mass spectrometry (TIMS) of actinides: Pushing the limits of accuracy and detection

Energy Technology Data Exchange (ETDEWEB)

Buerger, Stefan; Boulyga, Sergei; Cunningham, Alan; Klose, Dilani; Koepf, Andreas; Poths, Jane [Safeguards Analytical Laboratory, International Atomic Energy Agency, Vienna (Austria); Richter, Stephan [Institute for Reference Materials and Measurements, JRC-EU, Geel (Belgium)

2010-07-01

New method developments in multi-collector thermal ionization mass spectrometry (MC-TIMS) for actinide isotope ratio analysis to improve accuracy and limits of detection will be presented. With respect to limits of detection, results on improving work function using various carbon additives will be reviewed and presented as well as developments in cavity ion source (as compared to standard flat ribbon filament ion source) for femto- and attogram levels of uranium, plutonium, and americium. With respect to accuracy, results on isotope ratio measurements of isotopes of uranium (relative accuracy of 0.3% to 0.01%) are presented with an example being U-234-Th-230 age-dating (NBL CRM 112-A). In this context, the importance of traceability (to the S.I. units) and the use of (certified) reference materials are emphasized. The focus of this presentation is on applications to nuclear safeguards / forensics.

TIMS-1, Multigroup Cross-Sections of Heavy Isotope Mixture with Resonance from ENDF/B

International Nuclear Information System (INIS)

Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi

1984-01-01

1 - Description of problem or function: TIMS-1 is a code for calculating the group constants of heavy resonant nuclei by using ENDF/ B-4 format data. This code calculates infinitely dilute cross sections and self-shielding factors as a function of composition sigma-0 temperature T and R-parameter, where R is the ratio of ato- mic number density of two different resonant nuclei. 2 - Method of solution: In the unresolved resonance region, a ladder of resonance parameters and levels is generated with Monte Carlo method. The temperature dependent cross sections are calculated with the Breit-Wigner single-level and multi-level formula. The neutron spectrum is accurately calculated by solving numerically the neutron slowing down equation using a recurrence formula for neutron slowing down source. 3 - Restrictions on the complexity of the problem: The maximum numbers of energy groups, temperatures and compositions are 60, 4 and 10 respectively

Anticipating Deep Mapping: Tracing the Spatial Practice of Tim Robinson

Directory of Open Access Journals (Sweden)

Jos Smith

2015-07-01

Full Text Available There has been little academic research published on the work of Tim Robinson despite an illustrious career, first as an artist of the London avant-garde, then as a map-maker in the west of Ireland, and finally as an author of place. In part, this dearth is due to the difficulty of approaching these three diverse strands collectively. However, recent developments in the field of deep mapping encourage us to look back at the continuity of Robinson’s achievements in full and offer a suitable framework for doing so. Socially engaged with living communities and a depth of historical knowledge about place, but at the same time keen to contribute artistically to the ongoing contemporary culture of place, the parameters of deep mapping are broad enough to encompass the range of Robinson’s whole practice and suggest unique ways to illuminate his very unusual career. But Robinson’s achievements also encourage a reflection on the historical context of deep mapping itself, as well as on the nature of its spatial practice (especially where space comes to connote a medium to be worked rather than an area/volume. With this in mind the following article both explores Robinson’s work through deep mapping and deep mapping through the work of this unusual artist.

Henry S. Turner, The English Renaissance Stage. Geometry, Poetics, and the Practical Spatial Arts 1580-1630 - Tim Fitzpatrick, Playwright, Space and Place in Early Modern Performance

Directory of Open Access Journals (Sweden)

Luigi Giuliani

2013-05-01

Full Text Available Review of Henry S. Turner, The English Renaissance Stage. Geometry, Poetics, and the Practical Spatial Arts 1580-1630, Oxford University Press, Oxford, 2006, reimpr. 2010, 326 pp. ISBN: 978-0-19-959545-7 y Tim Fitzpatrick, Playwright, Space and Place in Early Modern Performance, Ashgate, Franham, 2011, 314 pp. ISBN: 978-1-4094-2827-5.

An improved FT-TIMS method of measuring uranium isotope ratios in the uranium-bearing particles

International Nuclear Information System (INIS)

Chen, Yan; Wang, Fan; Zhao, Yong-Gang; Li, Li-Li; Zhang, Yan; Shen, Yan; Chang, Zhi-Yuan; Guo, Shi-Lun; Wang, Xiao-Ming; Cui, Jian-Yong; Liu, Yu-Ang

2015-01-01

An improved method of Fission Track technique combined with Thermal Ionization Mass Spectrometry (FT-TIMS) was established in order to determine isotope ratio of uranium-bearing particle. Working standard of uranium oxide particles with a defined diameter and isotopic composition were prepared and used to review the method. Results showed an excellent agreement with certified values. The developed method was used to analyze isotope ratio of single uranium-bearing particle in swipe samples successfully. The analysis results of uranium-bearing particles in swipe samples accorded with the operation history of the origin. - Highlights: • The developed method was successfully applied in the analysis of real swipe sample. • Uranium-bearing particles were confined in the middle of track detector. • The fission tracks of collodion film and PC film could be confirmed each other. • The thickness of collodion film should be no more than about 60 μm. • The method could avoid losing uranium-bearing particles in the etching step.

Zircon and allanite U-Pb ID-TIMS ages of vaugnerites from the Calzadilla pluton, Salamanca (Spain): dating mantle-derived magmatism and post-magmatic subsolidus overprint

International Nuclear Information System (INIS)

López-Moro, F.J.; Romer, R. L.; López-Plaza, M.; González Sánchez, M.

2017-01-01

Basic to intermediate high-K, high-Mg mantle-derived rocks occur throughout the Iberian Massif and are particularly important in the Tormes Dome, where vaugnerites form several stocks and small plutons. One of the largest and geochemically most variable among these plutons is the Calzadilla pluton in the Tormes Dome that crystallized at 318 ± 1.4Ma (Bashkirian; U-Pb TIMS zircon). This age reveals that the vaugnerite pluton was emplaced during the transition from late D2 extensional deformation to early D3 contractional deformation (319 to 317Ma). Large-scale extension in the area resulted, on one hand, in extensive anatexis in the crust due to quasiisothermal decompression and mica-dehydration melting and, on the other hand, in the upwelling of the mantle, which induced partial melting of the enriched domains in the lithospheric mantle. The driving reason why crustal and mantle melts were coeval is extension. The U-Pb ID-TIMS age of allanite is not related to the emplacement nor cooling of the Calzadilla vaugnerite, but it seems to be related to a younger subsolidus overprint ca. 275Ma that, in the scale of the Central Iberian Zone, corresponds to a period of hydrothermal alteration, including episyenite formation and tungsten mineralization.

Zircon and allanite U-Pb ID-TIMS ages of vaugnerites from the Calzadilla pluton, Salamanca (Spain): dating mantle-derived magmatism and post-magmatic subsolidus overprint

Energy Technology Data Exchange (ETDEWEB)

López-Moro, F.J.; Romer, R. L.; López-Plaza, M.; González Sánchez, M.

2017-07-01

Basic to intermediate high-K, high-Mg mantle-derived rocks occur throughout the Iberian Massif and are particularly important in the Tormes Dome, where vaugnerites form several stocks and small plutons. One of the largest and geochemically most variable among these plutons is the Calzadilla pluton in the Tormes Dome that crystallized at 318 ± 1.4Ma (Bashkirian; U-Pb TIMS zircon). This age reveals that the vaugnerite pluton was emplaced during the transition from late D2 extensional deformation to early D3 contractional deformation (319 to 317Ma). Large-scale extension in the area resulted, on one hand, in extensive anatexis in the crust due to quasiisothermal decompression and mica-dehydration melting and, on the other hand, in the upwelling of the mantle, which induced partial melting of the enriched domains in the lithospheric mantle. The driving reason why crustal and mantle melts were coeval is extension. The U-Pb ID-TIMS age of allanite is not related to the emplacement nor cooling of the Calzadilla vaugnerite, but it seems to be related to a younger subsolidus overprint ca. 275Ma that, in the scale of the Central Iberian Zone, corresponds to a period of hydrothermal alteration, including episyenite formation and tungsten mineralization.

MENGGAGAS PENDIDIKAN BERWAWASAN KEWIRAUSAHAAN DI PERGURUAN TINGGI ISLAM: STUDI KASUS FAKULTAS SYARI`AH DAN EKONOMI ISLAM IAIN “SMH” BANTEN 2014-2015

Directory of Open Access Journals (Sweden)

NUR HIDAYAH

2016-03-01

� Abstrak. Menggagas Pendidikan Berwawasan Kewirausahaan Di Perguruan Tinggi Islam: Studi Kasus Fakultas Syari`Ah Dan Ekonomi Islam Iain “Smh” Banten 2014-2015. Penelitian ini berangkat dari keprihatinan terhadap tingginya tingkat pengangguran di kalangan para sarjana lulusan perguruan tinggi (Islam dan masih rendahnya proporsi pengusaha di Indonesia. Padahal tingginya proporsi pengusaha dapat menjadi salah satu indikator kemakmuran sebuah negara. Oleh karena itu timbul pertanyaan sejauh mana nilai-nilai Islam mendorong budaya wirausaha di kalangan umatnya? Dan bagaimana budaya wirausaha ditumbuh-kembangkan di lembaga pendidikan tinggi Islam? Penelitian ini bersifat deskriptif eskploratif dengan studi kasus pendidikan kewirausahaan di Fakultas Syari`ah dan Ekonomi Islam (FSEI IAIN “SMH” Banten. Hasil penelitian menunjukkan bahwa kurikulum prodi-prodi yang ada di FSEI belum sepenuhnya berwawasan kewirausahaan. Mahasiswa umumnya banyak dibekali dengan kompetensi dan ketrampilan yang mempersiapkan mereka sebagai sarjana ekonomi syari`ah yang akan mengisi profesi-profesi yang membutuhkan kompetensi di bidang ini seperti manajer, dosen, peneliti, dewan pengawas syariah, dan sebagainya, ketimbang profesi wirausahawan yang berkompetensi untuk merintis usaha dari bawah. Untuk membangun prodi kewirausahaan Islam/bisnis syari`ah di FSEI IAIN SMHB dibutuhkan political will yang kuat dari tidak hanya pihak kampus tetapi juga lembaga otoritas seperti Diktis Kemenag untuk memfasilitasi berdirinya prodi ini baik dari segi perizinan maupun pendanaan. Studi kelayakan awal yang lebih komprehensif perlu dilakukan untuk memetakan kebutuhan sarana dan prasarana seperti kebutuhan formasi dosen yang qualified di bidangnya, struktur kurikulum yang dapat membekali mahasiswa dengan berbagai karakter dan ketrampilan sebagai (calon pengusaha handal, dan sistem perekrutan untuk menjaring calon mahasiswa unggul. Mengingat profesi ini sangat berhubungan erat dengan sektor rill, perlu dibangun

The TiM system: developing a novel telehealth service to improve access to specialist care in motor neurone disease using user-centered design.

Science.gov (United States)

Hobson, Esther V; Baird, Wendy O; Partridge, Rebecca; Cooper, Cindy L; Mawson, Susan; Quinn, Ann; Shaw, Pamela J; Walsh, Theresa; Wolstenholme, Daniel; Mcdermott, Christopher J

2018-08-01

Attendance at a specialist multidisciplinary motor neurone disease (MND) clinic is associated with improved survival and may also improve quality of life and reduce hospital admissions. However, patients struggle to travel to clinic and may experience difficulties between clinic visits that may not be addressed in a timely manner. We wanted to explore how we could improve access to specialist MND care. We adopted an iterative, user-centered co-design approach, collaborating with those with experience of providing and receiving MND care including patients, carers, clinicians, and technology developers. We explored the unmet needs of those living with MND, how they might be met through service redesign and through the use of digital technologies. We developed a new digital solution and performed initial testing with potential users including clinicians, patients, and carers. We used these findings to develop a telehealth system (TiM) using an Android app into which patients and carers answer a series of questions about their condition on a weekly basis. The questions aim to capture all the physical, emotional, and social difficulties associated with MND. This information is immediately uploaded to the internet for review by the MND team. The data undergoes analysis in order to alert clinicians to any changes in a patient or carer's condition. We describe the benefits of developing a novel digitally enabled service underpinned by participatory design. Future trials must evaluate the feasibility and acceptability of the TiM system within a clinical environment.

Reviewer Volume 27, Tahun 2007

OpenAIRE

Volume 27, Tahun 2007, Reviewer

2007-01-01

1. Abdul Rozaq, Dr., Ir., DAA Jurusan Teknik Pertanian (TEP), Fakultas Teknologi Pertanian (FTP), Universitas Gadjah Mada (UGM), Yogyakarta2. Bambang Purwantana, Ir., Dr., M.Agr. Jurusan TEP, FTP-UGM3. Chusnul Hidayat, Ir., Dr. Jurusan Teknologi Pangan dan Hasil Pertanian (TPHP), Fakultas Teknologi Pertanian (FTP), Universitas Gadjah Mada (UGM), Yogyakarta4. Haryadi, Ir., Dr., Prof., M. App. Sc. Jurusan TPHP, FTP-UGM5. Lilik Sutiarso, Ir., Dr., M. Eng. Jurusan TEP, FTP-UGM6. Pudji Hastuti, Ir...

Precise determination of δ88Sr in rocks, minerals, and waters by double-spike TIMS: A powerful tool in the study of chemical, geologic, hydrologic and biologic processes

Science.gov (United States)

Neymark, Leonid A.; Premo, Wayne R.; Mel'nikov, Nikolay N.; Emsbo, Poul

2014-01-01

We present strontium isotopic (88Sr/86Sr and 87Sr/86Sr) results obtained by 87Sr–84Sr double spike thermal ionization mass-spectrometry (DS-TIMS) for several standards as well as natural water samples and mineral samples of abiogenic and biogenic origin. The detailed data reduction algorithm and a user-friendly Sr-specific stand-alone computer program used for the spike calibration and the data reduction are also presented. Accuracy and precision of our δ88Sr measurements, calculated as permil (‰) deviations from the NIST SRM-987 standard, were evaluated by analyzing the NASS-6 seawater standard, which yielded δ88Sr = 0.378 ± 0.009‰. The first DS-TIMS data for the NIST SRM-607 potassium feldspar standard and for several US Geological Survey carbonate, phosphate, and silicate standards (EN-1, MAPS-4, MAPS-5, G-3, BCR-2, and BHVO-2) are also reported. Data obtained during this work for Sr-bearing solids and natural waters show a range of δ88Sr values of about 2.4‰, the widest observed so far in terrestrial materials. This range is easily resolvable analytically because the demonstrated external error (±SD, standard deviation) for measured δ88Sr values is typically ≤0.02‰. It is shown that the “true” 87Sr/86Sr value obtained by the DS-TIMS or any other external normalization method combines radiogenic and mass-dependent mass-fractionation effects, which cannot be separated. Therefore, the “true” 87Sr/86Sr and the δ87Sr parameter derived from it are not useful isotope tracers. Data presented in this paper for a wide range of naturally occurring sample types demonstrate the potential of the δ88Sr isotope tracer in combination with the traditional radiogenic 87Sr/86Sr tracer for studying a variety of biological, hydrological, and geological processes.

The de-totalization of history in Tim O`Brien`s The Things They Carried (1990DOI:10.5007/2175-8026.2010n59p13

Directory of Open Access Journals (Sweden)

Gisele Manganelli Fernandes

2010-03-01

Full Text Available This paper aims at discussing how Tim O’Brien, a veteran of the Vietnam War, reviews the American involvement in the conflict in his novel The Things They Carried (1990. The author shows the perspective of the soldiers in the stories and, therefore, presents other possibilities to analyze that historical fact. The interplay of fiction and truth is essential for O’Brien to reach the objective of reevaluating official history in order to make the readers rethink the past.

Bacillus coagulans GBI-30, 6086 increases plant protein digestion in a dynamic, computer-controlled in vitro model of the small intestine (TIM-1).

Science.gov (United States)

Keller, D; Van Dinter, R; Cash, H; Farmer, S; Venema, K

2017-05-30

The aim of this study was to assess the potential of the probiotic Bacillus coagulans GBI-30, 6086 [GanedenBC 30 ] (BC30) to aid in protein digestion of alimentary plant proteins. To test this, three plant proteins, from pea, soy and rice, were digested in a validated in vitro model of the stomach and small intestine (TIM-1) in the absence and in the presence of BC30. Samples were taken from the TIM-1 fractions that mimic uptake of amino acids by the host and analysed for α-amino nitrogen (AAN) and total nitrogen (TN). Both were increased by BC30 for all three plant proteins sources. The ratio of TN/AAN indicated that for pea protein digestion was increased by BC30, but the degree of polymerisation of the liberated small peptides and free amino acids was not changed. For soy and rice, however, BC30 showed a 2-fold reduction in the TN/AAN ratio, indicating that the liberated digestion products formed during digestion in the presence of BC30 were shorter peptides and more free amino acids, than those liberated in the absence of BC30. As BC30 increased protein digestion and uptake in the upper gastrointestinal (GI) tract, it consequently also reduced the amount of protein that would be delivered to the colon, which could there be fermented into toxic metabolites by the gut microbiota. Thus, the enhanced protein digestion by BC30 showed a dual benefit: enhanced amino acid bioavailability from plant proteins in the upper GI tract, and a healthier environment in the colon.

Permian U-Pb (CA-TIMS) zircon ages from Australia and China: Constraining the time scale of environmental and biotic change

Science.gov (United States)

Denyszyn, S. W.; Mundil, R.; Metcalfe, I.; He, B.

2010-12-01

In eastern Australia, the interconnected Bowen and Sydney Basins are filled with terrestrial sediments of late Paleozoic to early Mesozoic age. These sedimentary units record significant evolutionary events of eastern Gondwana during the time interval between two major mass extinctions (end Middle Permian and Permian-Triassic), and also provide lithological evidence for the Carboniferous-Permian Late Paleozoic Ice Age of southern Pangea, considered to be divisible into up to seven discrete glaciation events in Australia [e.g., 1]. These glaciations are currently assigned ages that indicate that the last of the glaciations predate the end Middle Permian mass extinction at ca. 260 Ma. However, the estimates for the time and durations are largely based on biostratigraphy and lithostratigraphy that, in the absence of robust and precise radioisotopic ages, are unacceptably fragile for providing an accurate high-resolution framework. Interbedded with the sediments are numerous tuff layers that contain zircon, many of which are associated with extensive coal measures in the Sydney and Bowen Basins. Published SHRIMP U-Pb zircon ages [2, 3] have been shown to be less precise and inaccurate when compared to ages applying the CA-TIMS method to the same horizons. Also within the late Middle Permian, the eruption of the Emeishan flood basalts in SW China has been proposed to have caused the end Middle Permian mass extinction [e.g., 4], though a causal link between these events demands a rigorous test that can only be provided by high-resolution geochronology. We present new U-Pb (CA-TIMS) zircon ages on tuff layers from the Sydney and Bowen Basins, with the purpose of generating a timescale for the Upper Permian of Australia to allow correlation with different parts of the world. Initial results, with permil precision, date a tuff layer within the uppermost Bandanna Fm. to ca. 252 Ma, a tuff within the Moranbah Coal Measures to ca. 256 Ma, and a tuff within the Ingelara Fm. to

PENGARUH KEMAMPUAN BACA TULIS AL-QUR’AN TERHADAP HASIL BELAJAR TAFSIR MAHASISWA FAKULTAS TARBIYAH DAN KEGURUAN UIN ALAUDDIN MAKASSAR

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Nuryamin Nuryamin

2015-06-01

Full Text Available Abstract: This study aimed to determine the effect of the ability to read and write al Quran on Tafseer learning achievement of the second semester students of the Department of Islamic Education and Teaching Faculty UIN Alauddin Makassar academic in year 2013/2014. The method used was quantitative. The variables in this research was the ability to read and write the Koran (X, and Tafseer learning achievement (Y. The population in this study is the second semester students of 2013/2014. The number of respondents were 40 students that was taken by using purposive sampling. The analysis technique used to answer the hypothesis in this study was a descriptive and simple regression analysis. The results showed that the ability to read and write the Koran (X did not significantly affect the Tafseer learning achievement with the R2 values of 0.081 and 0.075 was the level of significance. The implications of this research is that UIN Alauddin Makassar give much more attention to improve the students’ ability to read and write the Koran. Therefore, it can provide quality improvement of the students themselves. Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh kemampuan baca tulis al-Qur’an terhadap hasil belajar tafsir mahasiswa semester II angkatan 2013/2014 Jurusan Pendidikan Agama Islam Fakultas Tarbiyah dan Keguruan UIN Alauddin Makassar. Metode penelitian yang digunakan ialah kuantitatif. Varia-bel dalam penelitian ini adalah Kemampuan baca tulis al-Qur’an (X, dan hasil belajar tafsir (Y. Populasi dalam penelitian ini adalah maha­siswa semester II angaktan 2013/2014. Jumlah responden sebanyak 40 Mahasiswa dengan memakai purposive sampling. Adapun teknik analisis yang digunakan untuk men­jawab hipotesis dalam penelitian ini adalah metode analisis deskriptif dan analisis regresi sederhana. Hasil penelitian menunjukkan bahwa kemampuan baca tulis al-Qur’an (X berpengaruh namun tidak signifikan terhadap nilai hasil belajar tafsir

The many Metaphysics within Physics. Essay review of 'The Metaphysics within Physics' by Tim Maudlin

Science.gov (United States)

Suárez, Mauricio

Tim Maudlin's new book The Metaphysics within Physics (Oxford University Press, 2007) collects six essays by one of the most thoughtful and original minds working in the philosophy of physics nowadays. Some had previously circulated informally for years. For example, Chapter 1 ('A Modest Proposal Concerning Laws, Counterfactuals and Explanations') is as old as my own philosophical career-I recall reading a draft in the early 1990s. The mere publication of such a long-awaited collection is therefore already good news. In addition, the degree of coherence and the lack of redundancy are greater than one would expect from a collection of disparate essays written at diverse times and with a range of different targets. The whole book can be understood coherently as an extended argument in favor of a particular 'physics-based' methodology for inquiry in metaphysics. This methodology recommends a detailed and thorough analysis of current physics as a benchmark for any thesis, dispute or argument in metaphysics. It follows that proper metaphysical inquiry must be suitably informed not just about the current state of play in analytical metaphysics but also about the current state of development of the relevant part of present day physics.

The technique of express vital determination of radiocesium specific activity in muscular tissue of large agricultural animals by means of the TIM-140 radiometer

International Nuclear Information System (INIS)

1997-01-01

The technique is intended for vital determination of cesium 137 specific activity in muscular tissue of large agricultural animals by means of the TIM-140 radiometer. The specific activity is determined using two measurements. With one measurement the gamma radiation detector is located on a lateral surface of coxofemoral part of the animal, and with the second measurement the absorbing gamma radiation screen is placed between the detector and zone of measurement. The external gamma background and useful signal are registered simultaneously. It allows to carry out measurements with a background till 0.05 mR/h without application of external screens

UK Institute of Physics (IOP) President Sir Gareth Roberts (right) at CERN on 9 July with (right to left) IOP council vice-president and distinguished physicist Peter Kalmus, CERN engineer Tim Watson and IOP director of science Peter Cooper

CERN Multimedia

Patrice Loiez

1999-01-01

UK Institute of Physics (IOP) President Sir Gareth Roberts (right) at CERN on 9 July with (right to left) IOP council vice-president and distinguished physicist Peter Kalmus, CERN engineer Tim Watson and IOP director of science Peter Cooper

Sistem Akuntansi Pengelolaan Dana Desa

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Ari Kuncara Widagdo

2016-10-01

Pada tahun 2014, pemerintah dan DPR mengesahkan Undang-Undang Nomor 6 Tahun 2014 mengatur tentang hak dan kewajiban desa. Hal pokok dalam UU adalah adanya alokasi dana desa yang cukup besar untuk setiap desa. Pengesahan UU ini menimbulkan polemik dimasyarakat. Beberapa pihak menyambut gembira terbitnya UU tersebut karena adanya dana desa akan menjadikan desa sebagai pusat pembangunan. Sebaliknya, beberapa pihak berpendapat bahwa dana desa yang akan dialokasikan kepada desa akan menimbulkan potensi korupsi yang dilakukan aparat desa. Sebagai tindak lanjut UU tersebut, pemerintah juga telah menerbitkan Peraturan Menteri Dalam Negeri No. 113/2015 tentang Pengelolaan Keuangan Desa yang menjadi panduan bagi pemerintah desa dalam penata kelolaan keuangan desa. Oleh karena itu, pengabdian masyarakat ini bertujuan untuk  mengetahui berbagai permasalahan yang dialami desa terkait pengelolaan dana desa dan memberikan bimbingan dan pelatihan pengelolaan dana desa. Pengabdian di lakukan di Desa Kismoyoso dan Desa Giriroto Kecamatan Ngemplak Boyolali. Pada tahap awal pengabdian dilakukan observasi dan diskusi secara langsung dengan Kepala Desa Kismoyoso dan  Giriroto. Hal ini  bertujuan untuk memahami lebih dalam permasalahan kedua desa terkait pengelolaan dana desa. Hasil observasi dan diskusi menunjukkan bahwa permasalahan utama yang timbul adalah rendahnya pengetahuan dari kepala desa di kedua desa tersebut berserta pelaksana teknis terkait pengelolaan keuangannya desa berdasarkan Permendagri No. 113/2015. Hal itu ditambah lagi dengan belum adanya tenaga pendamping dari Kabupaten Boyolali yang diturunkan untuk mendampingi di kedua desa tersebut. Tim pengabdian menganggap pelaporan keuangan dana desa secara komputer merupakan solusi untuk mengatasi kendala tersebut. Permendagri No. 113/2015 hanya mengatur  format-format pelaporan secara manual dan tidak mensyaratkan adanya komputerisasi dalam pelaporannya. Disisi lain,  teknologi informasi komputer (TIK telah semakin

Fleeing War. Due strategie di diserzione letteraria:I parenti del Sud di Carlo Montella e Going After Cacciato di Tim O’Brien

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Giulio Segato

2014-10-01

Full Text Available Il saggio indaga due diverse strategie di diserzione rappresentate in due romanzi di guerra: I parenti del sud di Carlo Montella e Going After Cacciato di Tim O’Brien. Nelle due opere analizzate la diserzione sembra essere collegata al conflitto che fa da sfondo al romanzo. Nel libro di Montella,il protagonista, ancora obnubilato dalle dottrine tautologiche fasciste, qualche settimana dopo l’armistizio di Cassibile decide di disertare e di fuggire nella villa di un’anziana parente, con lo scopo di rinsavire dall’ideologia del regime. Nel romanzo di O’Brien, invece, la fuga messa in scena dall’autore sembra avere gli stessi tratti grotteschi e assurdi del conflitto in cui è stato catapultato il protagonista,la Guerra del Vietnam.

La traducción al español de The Undercover Economist de Tim Harford: Consecuencias comerciales de la reducción de costes de traducción

OpenAIRE

Gutiérrez de las Heras, Marina

2014-01-01

[SP] Siempre se alude a la invisibilidad del traductor como un recinto del que este solo ha de salir si es para reforzar la calidad de su producto. Pero, ¿qué pasa cuando es precisamente la traducción la que entorpece la lectura? El economista camuflado, del economista Tim Harford, es un libro que pretende acercar la economía a personas legas en la materia. Está publicado por el Grupo Planeta y traducido por la agencia argentina Redactores en Red y se considera un superventas de la literatura...

Radiogenic Isotopes As Paleoceanographic Tracers in Deep-Sea Corals: Advances in TIMS Measurements of Pb Isotopes and Application to Southern Ocean Corals

Science.gov (United States)

Wilson, D. J.; van de Flierdt, T.; Bridgestock, L. J.; Paul, M.; Rehkamper, M.; Robinson, L. F.; Adkins, J. F.

2014-12-01

Deep-sea corals have emerged as a valuable archive of deep ocean paleoceanographic change, with uranium-series dating providing absolute ages and the potential for centennial resolution. In combination with measurements of radiocarbon, neodymium isotopes and clumped isotopes, this archive has recently been exploited to reconstruct changes in ventilation, water mass sourcing and temperature in relation to millennial climate change. Lead (Pb) isotopes in both corals and seawater have also been used to track anthropogenic inputs through space and time and to trace transport pathways within the oceans. Better understanding of the oceanic Pb cycle is emerging from the GEOTRACES programme. However, while Pb isotopes have been widely used in environmental studies, their full potential as a (pre-anthropogenic) paleoceanographic tracer remains to be exploited. In deep-sea corals, challenges exist from low Pb concentrations in aragonite in comparison to secondary coatings, the potential for contamination, and the efficient elemental separation required for measurement by thermal ionisation mass spectrometry (TIMS). Here we discuss progress in measuring Pb isotopes in coral aragonite using a 207Pb-204Pb double spike on a ThermoFinnigan Triton TIMS. For a 2 ng NIST-981 Pb standard, the long term reproducibility (using 1011 Ω resistors) is ~1000 ppm (2 s.d.) on 206Pb/204Pb, 207Pb/204Pb and 208Pb/204Pb ratios. We now show that using a new 1012 Ω resistor to measure the small 204Pb beam improves the internal precision on these ratios from ~500 ppm (2 s.e.) to ~250 ppm (2 s.e.) and we envisage a potential improvement in the long term reproducibility as a consequence. We further assess the internal precision and external reproducibility of our method using a BCR-2 rock standard and an in-house coral standard. Preliminary evidence on the application of this method to natural samples is derived from cleaning experiments and replication tests on deep-sea corals from the Southern

USULAN PERBAIKAN KUALITAS PELAYANAN ADMINISTRASI MAHASISWA MENGGUNAKAN METODE QUALITY FUNCTION DEPLOYMENT (QFD

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Vera Devani

2012-12-01

Full Text Available Agar pelayanan yang dilakukan di bagian administrasi mahasiswa Fakultas Sains dan Teknologi UIN SUSKA Riau dapat memenuhi keinginan mahasiswa maka dilakukan perbaikan kualitas yang menitikberatkan pada pemenuhan keinginan mahasiswa. Perbaikan kualitas menggunakan metode Quality Function Deployment dapat menerjemahkan keinginan mahasiswa ke dalam tindkan perbaikan kualitas dari bagian administrasi fakultas. Dari hasil penelitian diperoleh beberapa tindakan sebagai usulan perbaikan kualitas pelayanan yaitu membuat SOP pengurusan administrasi dan mensosialisasikannya, menentukan waktu tiap bentuk pengurusan administrasi, melakukan perencanaan kebutuhan administrasi mahasiswa dan perpustakaan sesuai dengan perkembangan teknologi, pegawai administrasi sebaiknya menguasai keahlian administrasi, pegawai administrasi memperlihatkan sikap dan kepribadian yang baik, dan dilakukan pengontrolan terhadap pelayanan administrasi.

Magmatic Longevity Constrained by ID-TIMS U-Pb Dating of Zircon and Titanite

Science.gov (United States)

Szymanowski, D.; Wotzlaw, J. F.; Ellis, B. S.; Bachmann, O.; Von Quadt, A.

2016-12-01

Clues about the timescales and thermal conditions associated with the growth and evacuation of large silicic magma reservoirs are frequently drawn from radiometric dating, diffusion modelling, or thermomechanical modelling. A growing amount of petrological and geochronological evidence, supported by thermal modelling, suggests that many silicic magma reservoirs may exist for some 104-106 years in the form of high-crystallinity mushes at relatively low temperatures ( 700-750°C; [1-3]). Geochronological studies addressing this issue typically utilise the U-Pb system in zircon capable of recording extended periods of crystallisation, particularly in evolved calc-alkaline systems that spend most of their lifetime zircon-saturated. In this study, we integrate U-Pb dating of zircon and titanite to investigate the longevity of the magma reservoir that produced the Kneeling Nun Tuff, a 35 Ma, >900 km3 crystal-rich rhyolitic super-eruption from the Mogollon-Datil volcanic field in New Mexico (USA). High-precision ID-TIMS U-Pb dates of single crystals of both zircon and titanite independently record a continuous crystallisation history over >400,000 years. We combine the dating of both accessory phases with textural, major, trace element and isotopic studies of single crystals, placing tight constraints on the thermal conditions of magma accumulation and storage while recording differentiation and rejuvenation processes within the magma reservoir. The results suggest a protracted `cool' upper-crustal storage of magma prior to the Kneeling Nun Tuff eruption followed by a melting event which reduced the magma crystallinity and conditioned it for eruption. [1] Bachmann & Bergantz (2004), J. Petrol. 45, 1565-1582. [2] Gelman et al. (2013), Geology 41, 759-762. [3] Cooper & Kent (2014), Nature 506, 480-483.

Analisis Faktor-Faktor Yang Mempengaruhi Kinerja Organisasi Pengelola Zakat

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Sugiyarti Fatma Laela

2014-03-01

Full Text Available Penelitian ini menguji faktor-faktor yang memiliki pengaruh signifikan terhadap kinerja efisiensi Organisasi Pengelola Zakat (OPZ. Efisiensi dalam penelitian ini difokuskan pada rasio program spending terhadap total spending. Penelitian ini merupakan penelitian empiris yang menggunakan data primer dan sekunder dengan metode cross section dari dua puluh tiga sampel OPZ. dengan menggunakan metode Ordinary Least Square (OLS, hasil penelitian ini menyimpulkan bahwa komposisi Dewan Pembina tidak memiliki pengruh yng signifikan terhdp efisiensi OPZ. Namun rasio jumlah Dewan Pengawas terhadap Direktur Pelaksana memiliki pengaruh yang signifikan secara statistik dengan efisiensi OPZ. Semakin tinggi rasio jumlah Dewan Pengawas terhadap Direktur Pelaksana, semakin efisien suatu OPZ. Demikian juga keberadaan laporan auditor independen akan meningkatkan efisiensi OPZ. Empat variabel independen lainnya yaitu, perubahan kompensasi yang dibayarkan kepada pegawai, penerapan program manajemen dan system budaya yang efficiency emphasis, struktur kelembagaan OPZ dan ukuran (size OPZ tidak terbukti memiliki pengaruh yang signifikan terhadap efisiensi. Variabel ekplanatori dalam model penelitian ini mampu menjelaskan 64.4 persen variasi pergerakan efisiensi OPZ.JEL Classification : I30, L23, L25, L30Keywords : OPZ, Kinerja Efisiensi, Program spending

Monitoring toxicity, DNA damage, and somatic mutations in tobacco plants growing in soil heavily polluted with polychlorinated biphenyls

Czech Academy of Sciences Publication Activity Database

Gichner, Tomáš; Lovecká, P.; Kochánková, L.; Macková, M.; Demnerová, K.

2007-01-01

Roč. 629, č. 1 (2007), s. 1-6 ISSN 1383-5718 R&D Projects: GA ČR GA521/05/0500 Grant - others:Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská(CZ) 1P05ME745; Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská(CZ) OC 117 Institutional research plan: CEZ:AV0Z50380511 Source of funding: V - iné verejné zdroje ; V - iné verejné zdroje ; V - iné verejné zdroje Keywords : comet assay * single-cell gel electrophoresis * gas chromatography Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.278, year: 2007

Isotope ratio measurements of pg-size plutonium samples using TIMS in combination with the 'Multiple Ion Counting' and filament carburization

Energy Technology Data Exchange (ETDEWEB)

Jakopic, Rozle; Richter, Stephan; Kuehn, Heinz; Aregbe, Yetunde [European Commission, Directorate General Joint Research Centre Institute for Reference Materials and Measurements, IRMM Retieseweg 111, B-2440 Geel (Belgium)

2008-07-01

A new sample preparation procedure for isotopic measurements using the Triton TIMS (Thermal Ionization Mass Spectrometer) was developed which employed the technique of carburization of rhenium filaments. Carburized filaments were prepared in a special vacuum chamber in which the filaments were heated and exposed to benzene vapor. Ionization efficiency was improved by an order of magnitude. Additionally, a new 'multi-dynamic' measurement technique was developed for Pu isotope ratio measurements using the 'multiple ion counting' (MIC) system. This technique was further combined with the filament carburization technique and applied to the NBL-137 isotopic standard and samples of the NUSIMEP 5 inter-laboratory comparison campaign. The results clearly show an improved precision and accuracy for the 'multi-dynamic' measurement procedure, compared to measurements carried out either in peak-jumping or in static mode using the MIC system with non-carburized filaments. (authors)

Pemahaman terhadap Konsep Pahala dan Dosa Serta Hubungannya Dengan Etos Kerja Dosen dan Pegawai Fakultas Ushuluddin dan Pemikiran Islam IAIN Raden Fatah Palembang

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Idrus Alkaf

2016-03-01

Full Text Available Artikel ini membahas tentang konsep pahala dan dosa dalam ajaran Islam dan pengaruhnya terhadap etos kerja dosen dan staf Fakultas Ushuluddin dan Pemikiran Islam, IAIN Raden Fatah Palembang. Pemahaman tentang pahala dan dosa, yang merupakan bagian dari doktrin etika dalam Islam ternyata memiliki peran dalam menentukan etos kerja. Kegiatan yang dianggap baik berdasarkan ajaran Islam pasti akan dihargai. Sebaliknya, mereka yang tidak menjalankan atau yang melanggar aturan akan mendapatkan dosa sebagai balasannya. Dengan menggunakan metode pengumpulan data melalui survei, observasi, wawancara atau kuesioner, dalam artikel ini, diketahui bahwa pemahaman dosen dan staf tentang pahala dan dosa ternyata sangat berhubungan dengan etos kerja mereka sehari-hari. Semakin baik tingkat pemahaman dosen dan staf dengan konsep pahala dan dosa, semakin tinggi etos kerja mereka. Ini menyiratkan bahwa pemahaman seseorang tentang konsep pahala dan dosa itu dapat mendorong orang untuk bekerja lebih baik, lebih serius dan lebih berhati-hati. Atau dengan kata lain, secara teologis pemahaman ini dapat berdampak pada aktivitas sehari-hari. This article discusses the concept of merit and sin in Islam and the influence by the work ethic of faculty and staff of the Faculty of Islamic Theology and Islamic Thought, Islamic State Institute Raden Fatah Palembang. Understanding of merit and sin, which is part of the doctrine of ethics in Islam to have a role in determining the work ethic. Activities that are considered good based on the teachings of Islam is believed to be rewarded. Vice versa, those who do not run or that violate the rules will get sin as a reward. By Idrus analysis using the method of data collection through the courts (survey, observation, interviews or questionnaires, in this article, Idrus found understanding of faculty and staff to the concept of merit and sin is very in touch with their work ethic in everyday tasks. Or the better the level of

PENGARUH PEMBELAJARAN KEWIRAUSAHAAN TERHADAP MOTIVASI BERWIRAUSAHA

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Reza Fahmi

2012-12-01

Full Text Available This study aims to explain the influence of entrepreneurship learning towards motivation to conduct business among students of Faculty of Ushuluddin at the Imam Bonjol State Institute of Islamic Studies of Padang. Data for this study was gathered through a population of students from four departments within the faculty, namely: Psikologi Islam (PI, Tafsir Hadist (TH, Perbandingan Agama (PA, Aqidah Filsafat (AF. Off the population, 92 students were chosen for the sample. Observation, questionnaire, and documentation were employed as the technique of data gathering. The findings show that there was a significant influence between the entrepreneurship learning and motivation to conduct business among students of Faculty of Ushuluddin IAIN Imam Bonjol Padang. =========================================== Penelitian ini bertujuan untuk menjelaskan pengaruh pembelajaran kewirausahaan terhadap motivasi berwirausaha mahasiswa Fakultas Ushuluddin Institut Agama Islam Negeri (IAIN Imam Bonjol Padang. Data penelitian ini diperoleh dari responden yang berasal dari Fakultas Ushuluddin IAIN Imam Bonjol Padang, yang terdiri dari empat jurusan: Psikologi Islam (PI, Tafsir Hadist (TH, Perbandingan Agama (PA, Aqidah Filsafat (AF dengan jumlah sampel sebanyak 92 orang. Pengumpulan data dilakukan dengan observasi langsung, angket dan dokumentasi. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan antara pembelajaran kewirausahaan dengan motivasi berwirausaha mahasiswa Fakultas Ushuluddin IAIN Imam Bonjol Padang.

Penyajian Data Komoditi Batik Kabupaten Sukoharjo Dengan Google Earth

OpenAIRE

Ukhti Ikhsani Larasati; Much Aziz Muslim

2016-01-01

Kabupaten Sukoharjo memiliki banyak potensi daerah yang merupakan komoditi unggulan kabupaten yaitu komoditi mebel kayu, mebel rotan, batik, tekstil dan produk tekstil, kaca grafir, kerajinan kulit/tatah sungging (wayang), kerajinan gitar, kerajinan gamelan, shuttlecock, jamu tradisional, emping mlinjo, sarung goyor, beras, dan alkohol. Dinas Perindustrian dan Perdagangan kabupaten Sukoharjo adalah salah satu pelaksana urusan Pemerintah Daerah kabupaten Sukoharjo di bidang perindustrian dan p...

High-precision timing of Nanhai coral by using MC-ICP-MS and TIMS techniques and its paleo-environmental significance

International Nuclear Information System (INIS)

Peng Zicheng; Nie Baofu; Chen Tegu

2004-01-01

The techniques of thermal ionization mass spectrometry (TIMS) and multicollector-inductively coupled plasma-mass spectrometry (MC-ICP-MS) were used for the high-precision timing of the domestic stalagmite standard (GBW04412), international coral standard (RKM-4) and the Nanhai corals. The results of uranium contents and the ratios of 234 U/ 238 U and 230 Th/ 234 U in the two standards measured by using two techniques were consistent within the error range. Most of the Nanhai corals have less than 3 μg/g of the uranium contents and 150 ± 5 of the δ 234 U(T) values, which means that the corals have not been subjected to the alternation since they were brought up 7000 years ago, therefore, they preserve the original environmental signals. The age sequence of the corals shows that three events of the high sea level happened in Nanhai area in the periods corresponding to 6799-6307 a B.P., 4472-4285 a B.P. and 1279-1012 a B.P. respectively. The above-mentioned three stages were relative to the Megathermal and Medieval Warm Periods in our country. (authors)

Development of CA-ID-TIMS zircon U–Pb dating technique at Guangzhou Institute of Geochemistry, Chinese Academy of Sciences

Directory of Open Access Journals (Sweden)

Yu-Ting Zhong

2017-06-01

Pretreatment protocols for zircon analysis, and community-wide innovations spurred on by EARTHTIME tends to be at the leading edge of technological development. Also, more and more Chinese researchers perform lots of laboratory work in improving the technique in China. Here we present the running condition, procedural blanks and zircon standards measurement results in the clean laboratory of the Guangzhou Institute of Geochemistry, Chinese Academy of Sciences (GIGCAS. The results show the total procedural blanks (Pbc are below ∼1 pg mostly, suitable for the sample pretreatment and operation. The 206Pb/238U dates of R33 and 500 Ma solution are 419.88 ± 0.94 Ma (n = 7; MSWD = 6.8 and 500.50 ± 0.19 Ma (n = 9; MSWD = 0.84, respectively. These results demonstrate that the CA-ID-TIMS procedure is well established at GIGCAS. Our efforts are beneficial to the development of EARTHTIME-CN program. In particular, when this technique is combined with the SIMS technique, it provides an efficient way to solve a number of geochronological problems encountered in China and worldwide.

PENGARUH PENGGUNAAN MEDIA SOSIAL INSTAGRAM TERHADAP CITRA TUBUH MAHASISWA FAKULTAS USHULUDDIN ADAB DAN DAKWAH IAIN PONOROGO TAHUN 2016

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Nadia Faidatun Nasiha

2017-12-01

merasakan dampak pemakaian berkelanjutan dari media sosial tersebut. Dalam ilmu psikologi ada sebuah istilah baru yang dinamakan Citra Tubuh, yaitu konsep seseorang dalam menilai penampilan, cara pandang maupun sikap dari segi psikologis maupun biologis. Instagram banyak dimanfaatkan oleh individu maupun kelompok yang mencoba mengenalkan pakaian mereka secara online dan hal itu memudahkan seorang konsumen dengan mudah dalam mengakses model fashion  yang mereka inginkan. Penelitian ini akan mengungkap pengaruh instagram terhadap citra tubuh mahasiswa Fakultas Ushuluddin Adab dan Dakwah IAIN Ponorogo. Metode yang digunakan adalah penelitian kuantitatif, teknik pengumpulan data menggunakan angket. Untuk uji validitas menggunakan rumus product momentdan uji reliabilitas menggunakan rumus Spearman brown. Sedangkan pada tahap analisis data menggunakan analisis Regresi Linier Sederhana. Dari hasil analisa data, peneliti menyimpulkan bahwa 1 Penggunaan media sosial instagram mahasiswa Fakultas Ushuluddin Adab dan Dakwah IAIN Ponorogo adalah kategori sedang dengan prosentase 59,37%. 2 Tingkat citra tubuh mahasiswa Fakultas Ushuluddin Adab dan DakwahPonorogo adalah kategori sedang dengan prosentase 65,62%. 3 Terdapat pengaruh antara media sosial instagram terhadap citra tubuh mahasiswa Jurusan  Ushuluddin Adab dan Dakwah IAIN Ponorogo karena Fhitung (9,8550 lebih besar dari Ftabel (taraf signifikansi 1% = 7,56 dan taraf signifikansi 5% = 4,17.   Keywords : Media Sosial Instagram, Citra Tubuh

High-precision ID-TIMS zircon U-Pb geochronology using new 1013 Ohm resistors

Science.gov (United States)

Von Quadt, A.; Buret, Y.; Large, S.; Peytcheva, I.; Trinquier, A.; Wotzlaw, J. F.

2015-12-01

Faraday cups equipped with high gain amplifiers provide a means to measure small ion beams in static mode without the limited linear range of ion counting systems. We tested the application of newly available 1013 Ohm resistors to ID-TIMS zircon U-Pb geochronology using a range of natural and synthetic reference materials. The TritonPlus-RPQ at the Institute of Geochemistry and Petrology, ETH Zurich, is equipped with five new 1013 Ohm resistors and one MasCom secondary electron multiplier, allowing to measure the 202-204-205-206-207-208Pb masses in static mode. U is measured subsequently as U-oxide (265-267-270UO2) during a second step, also in static Faraday mode. The gain calibration of the 1013 Ohm resistors was performed using the procedure of Trinquier (2014), with 144Nd-146Nd being measured using 1011 Ohm resistor and 142-143-145-148-150Nd being measured using 1013 Ohm resitors (Trinquier, 2014; Koornneef et al., 2014). Standard deviations of the noise in all five new 1013 Ohm resistors are lower than 5.0 x 10-6 over a 6 month period, with no shift occurring over this time interval. This new detector set-up was tested by analyzing natural zircon standard materials and synthetic U/Pb solutions (www.earthime.org), ranging in age from ~2 Ma to ~600 Ma. All natural zircon standards were chemically abraded (Mattinson, 2005) and all samples were spiked with the ET2535 tracer solution. U-Pb dates obtained using the static measurement routine are compared to measurements employing dynamic peak jumping routines on the MasCom multiplier. This study illustrates the benefits and current limitations of using high gain amplifiers to measure small ion beams for zircon U-Pb geochronology compared to conventional dynamic ion counting techniques. Mattinson, J.M. (2005) Chemical Geology 220:47-66; Trinquier, A. (2014) Application Note 30281; Koornneef, J. et al (2014) Analytica Chimica Acta 819:49-55.

PENINGKATAN SELF-REGULATED LEARNING SKILLS MAHASISWA PADA MATA KULIAH AKUNTANSI PENGANTAR MELALUI PROBLEM-BASED LEARNING

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Andian Ari Istiningrum

2017-02-01

Full Text Available Abstrak: Penelitian ini bertujuan untuk mengetahui: (i peningkatan self-regulated learning skills (SRL melalui implementasi problem-based learning (PBL dan (ii peningkatan kemampuan dosen pelaksana dalam mengimplementasikan PBL. Penelitian ini merupakan lesson study terbagi atas dua siklus dimana masing-masing siklus terdiri atas tahap plan, do, dan see.Subjek penelitian adalah mahasiswa Akuntansi Universitas Negeri Yogyakarta semester pertama yang mengambil mata kuliah Akuntansi Pengantar sebanyak 35 mahasiswa. Data mengenai SRL dikumpulkan dengan angket yang diisi mahasiswa, sedangkan data mengenai implementasi PBL oleh dosen pelaksana dikumpulkan dengan lembar observasi yang diisi oleh mahasiswa dan anggota timlesson study. Data dianalisis secara deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa (i PBL mampu meningkatkan SRL mahasiswa walaupun tingkat ketercapaiannya masih belum optimal, dan (ii kemampuan dosen pelaksana dalam melaksanakan PBL meningkat dengan tingkat ketercapaian yang optimal. IMPROVING STUDENTS’ SELF-REGULATED LEARNING SKILLS IN THE INTRODUCTION TO ACCOUNTING COURSE THROUGH PROBLEM-BASED LEARNING Abstract: This study aims to reveal (i the improvement of self-regulated learning skills (SRL through problem-based learning (PBL, and (ii the improvement of lecturers’ performance in implementing PBL. To achieve these purposes, a lesson study with two cycles was conducted. Each cycle consisted of plan phase, do phase, and see phase. The study was conducted to the 1 semester Accounting Students at Yogyakarta State University who attended the Introduction to Accounting course. There were 35 students as the research subjects. The sampling technique used to collect data regarding SRL was questionnaires which were filled out by the students; while the data regarding the lecturer’s performance was collected by observation sheets that were filled out by students and members of lesson study group. The study

A comparative study of isotopic analysis of plutonium from organic and aqueous media by thermal ionization mass spectrometry (TIMS)

International Nuclear Information System (INIS)

Rao, Radhika M.; Mirashi, Nirupama N.; Khodade, P.S.; Shah, P.M.; Parab, A.R.; Govindan, R.; Aggarwal, S.K.

2003-01-01

For isotopic analysis of plutonium (Pu) in irradiated nuclear fuel samples, it is normally separated from Am, U and fission products by anion exchange method in nitrate medium. However, stripping of Pu from the column by dilute HNO 3 acid is slow due to tailing which requires long elution times and reduces the concentration of Pu in the eluted solution. The desorption of Pu from the column can be enhanced by using more dilute HNO 3 but there are problems of hydrolysis and polymer formation. Formic acid and ascorbic acid in formic acid are reported to be promising eluents for plutonium. Formic acid is also a good solvent for Pu. Further, the presence of ascorbic acid helps in reducing Pu (IV) to Pu (III) thereby leading to faster elution as well as better recovery in smaller volumes of the eluant and hence higher Pu concentrations in the collected fraction. This would circumvent the need of subsequent concentration steps allowing direct loading of Pu on the filament for analysis by TIMS. The aim of the present work was to compare the elution behaviour and mass spectrometric analysis of Pu using formic acid, formic acid + ascorbic acid and nitric acid with respect to ion current behaviour and isotopic ratios obtained

Penilaian Dosen dan Fakultas dalam Persepsi Mahasiswa Fakultas Ekonomi Unmas Denpasar

OpenAIRE

Novitasari, Ni Luh Gde; Merawati, Luh Komang

2015-01-01

Nowadays Indonesia has been entering a new competitive era which changing very fast especially on facing AFTA year 2015. It is neccessary to improving the quality of human resources in order to gain more competitive advantages by improving the quality of education process in college. This study was a preliminary research to determine students' perception related to assessment of lectures and Economic Faculty of Mahasaraswati University Denpasar. The respondents were 331 students from Economic...

Determinants in the Ig Variable Domain of Human HAVCR1 (TIM-1) Are Required To Enhance Hepatitis C Virus Entry.

Science.gov (United States)

Kachko, Alla; Costafreda, Maria Isabel; Zubkova, Iryna; Jacques, Jerome; Takeda, Kazuyo; Wells, Frances; Kaplan, Gerardo; Major, Marian E

2018-03-15

Hepatitis C virus (HCV) is the leading cause of chronic hepatitis in humans. Several host molecules participate in HCV cell entry, but this process remains unclear. The complete unraveling of the HCV entry process is important to further understand viral pathogenesis and develop therapeutics. Human hepatitis A virus (HAV) cellular receptor 1 (HAVCR1), CD365, also known as TIM-1, functions as a phospholipid receptor involved in cell entry of several enveloped viruses. Here, we studied the role of HAVCR1 in HCV infection. HAVCR1 antibody inhibited entry in a dose-dependent manner. HAVCR1 soluble constructs neutralized HCV, which did not require the HAVCR1 mucinlike region and was abrogated by a mutation of N to A at position 94 (N94A) in the Ig variable (IgV) domain phospholipid-binding pocket, indicating a direct interaction of the HAVCR1 IgV domain with HCV virions. However, knockout of HAVCR1 in Huh7 cells reduced but did not prevent HCV growth. Interestingly, the mouse HAVCR1 ortholog, also a phospholipid receptor, did not enhance infection and a soluble form failed to neutralize HCV, although replacement of the mouse IgV domain with the human HAVCR1 IgV domain restored the enhancement of HCV infection. Mutations in the cytoplasmic tail revealed that direct HAVCR1 signaling is not required to enhance HCV infection. Our data show that the phospholipid-binding function and other determinant(s) in the IgV domain of human HAVCR1 enhance HCV infection. Although the exact mechanism is not known, it is possible that HAVCR1 facilitates entry by stabilizing or enhancing attachment, leading to direct interactions with specific receptors, such as CD81. IMPORTANCE Hepatitis C virus (HCV) enters cells through a multifaceted process. We identified the human hepatitis A virus cellular receptor 1 (HAVCR1), CD365, also known as TIM-1, as a facilitator of HCV entry. Antibody blocking and silencing or knockout of HAVCR1 in hepatoma cells reduced HCV entry. Our findings that the

Evaluasi Kinerja KKIP Dalam Kerjasama Republik Indonesia-Korea Selatan Pada Pembangunan Kapal Selam Untuk Mendukung Ketahanan Alutsista TNI Angkatan Laut

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Tunggul Prasetyo

2017-04-01

Full Text Available ABSTRACT This study was aimed to knew and analyzed the implementation of the cooperation between Republik Indonesia and South Korea in the construction of submarines ,to the Navy defense equipment resilience. The method used by the researchers in this study was a qualitative descriptive method. Data collection techniques used three techniques, in-depth interviews, observation, library and documentation. Objects in this study that the parties involved in the cooperation Indonesia South Korea in the construction of submarines, especially the executive team officials Defence Industry Policy Committee (KKIP. The results showed that in the implementation of cooperation Indonesia South Korea in the construction of the submarine still lacks the strength of its bargaining Indonesian government, especially KKIP and Defense industry involved in this cooperation program. This was indicated by the presence of the technology transfer process was still below of 85 % as a basis for accelerating the revitalization of the defense industry in achieving the navy defense resilience ABSTRAK Penelitian ini bertujuan untuk mengetahui dan menganalisis pelaksanaan kerjasama yang dilaksanakan indonesia-Korea Selatan dalam Pembangunan Kapal Selam dan mengevaluasi kerjasama Indonesia Korea selatan dalam pembangunan kapal selam terhadap ketahanan alutsista TNI AL. Metode yang digunakan dalam penelitian adalah metode deskriptif kualitatif. Teknik pengumpulan data menggunakan tiga teknik, yaitu wawancara mendalam, observasi, kepustakaan, serta studi dokumentasi. Objek dalam penelitian ini yaitu para pihak yang terlibat dalam kerjasama Indonesia Korea selatan dalam pembangunan kapal selam, khususnya para pejabat tim pelaksana Komite Kebijakan Industri Pertahanan (KKIP. Hasil penelitian menunjukkan bahwa dalam pelaksanaan kerjasama indonesia Korea selatan dalam pembangunan kapal selam memiliki kekurangan berupa kekuatan tawar menawar pemerintahan Indonesia, khususnya KKIP

Substrate-Induced Dimerization of Engineered Monomeric Variants of Triosephosphate Isomerase from Trichomonas vaginalis.

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Samuel Lara-Gonzalez

Full Text Available The dimeric nature of triosephosphate isomerases (TIMs is maintained by an extensive surface area interface of more than 1600 Å2. TIMs from Trichomonas vaginalis (TvTIM are held in their dimeric state by two mechanisms: a ball and socket interaction of residue 45 of one subunit that fits into the hydrophobic pocket of the complementary subunit and by swapping of loop 3 between subunits. TvTIMs differ from other TIMs in their unfolding energetics. In TvTIMs the energy necessary to unfold a monomer is greater than the energy necessary to dissociate the dimer. Herein we found that the character of residue I45 controls the dimer-monomer equilibrium in TvTIMs. Unfolding experiments employing monomeric and dimeric mutants led us to conclude that dimeric TvTIMs unfold following a four state model denaturation process whereas monomeric TvTIMs follow a three state model. In contrast to other monomeric TIMs, monomeric variants of TvTIM1 are stable and unexpectedly one of them (I45A is only 29-fold less active than wild-type TvTIM1. The high enzymatic activity of monomeric TvTIMs contrast with the marginal catalytic activity of diverse monomeric TIMs variants. The stability of the monomeric variants of TvTIM1 and the use of cross-linking and analytical ultracentrifugation experiments permit us to understand the differences between the catalytic activities of TvTIMs and other marginally active monomeric TIMs. As TvTIMs do not unfold upon dimer dissociation, herein we found that the high enzymatic activity of monomeric TvTIM variants is explained by the formation of catalytic dimeric competent species assisted by substrate binding.

Improved 206Pb/238U microprobe geochronology by the monitoring of a trace-element-related matrix effect; SHRIMP, ID-TIMS, ELA-ICP-MS and oxygen isotope documentation for a series of zircon standards

Science.gov (United States)

Black, L.P.; Kamo, S.L.; Allen, C.M.; Davis, D.W.; Aleinikoff, J.N.; Valley, J.W.; Mundil, R.; Campbell, I.H.; Korsch, R.J.; Williams, I.S.; Foudoulis, C.

2004-01-01

Precise isotope dilution-thermal ionisation mass spectrometry (ID-TIMS) documentation is given for two new Palaeozoic zircon standards (TEMORA 2 and R33). These data, in combination with results for previously documented standards (AS3, SL13, QGNG and TEMORA 1), provide the basis for a detailed investigation of inconsistencies in 206Pb/238U ages measured by microprobe. Although these ages are normally consistent between any two standards, their relative age offsets are often different from those established by ID-TIMS. This is true for both sensitive high-resolution ion-microprobe (SHRIMP) and excimer laser ablation-inductively coupled plasma-mass spectrometry (ELA-ICP-MS) dating, although the age offsets are in the opposite sense for the two techniques. Various factors have been investigated for possible correlations with age bias, in an attempt to resolve why the accuracy of the method is worse than the indicated precision. Crystallographic orientation, position on the grain-mount and oxygen isotopic composition are unrelated to the bias. There are, however, striking correlations between the 206Pb/238U age offsets and P, Sm and, most particularly, Nd abundances in the zircons. Although these are not believed to be the primary cause of this apparent matrix effect, they indicate that ionisation of 206Pb/238U is influenced, at least in part, by a combination of trace elements. Nd is sufficiently representative of the controlling trace elements that it provides a quantitative means of correcting for the microprobe age bias. This approach has the potential to reduce age biases associated with different techniques, different instrumentation and different standards within and between laboratories. Crown Copyright ?? 2004 Published by Elsevier B.V. All rights reserved.

Yeast Interacting Proteins Database: YHR114W, YDL217C [Yeast Interacting Proteins Database

Lifescience Database Archive (English)

Full Text Available y (0) YDL217C TIM22 Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopi...rey gene name TIM22 Prey description Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic

A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.

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Bridgette Janine Connell

Full Text Available Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that IND02, a type A procyanidin polyphenol extracted from cinnamon, that features trimeric and pentameric forms displays an anti-HIV-1 activity against CXCR4 and CCR5 viruses with 1-7 μM ED50 for the trimer. Competition experiments, using a surface plasmon resonance-based binding assay, revealed that IND02 inhibited envelope binding to CD4 and heparan sulphate (HS as well as to an antibody (mAb 17b directed against the gp120 co-receptor binding site with an IC50 in the low μM range. IND02 has thus the remarkable property of simultaneously blocking gp120 binding to its major host cell surface counterparts. Additionally, the IND02-trimer impeded up-regulation of the inhibitory receptors Tim-3 and PD-1 on CD4+ and CD8+ cells, thereby demonstrating its beneficial effect by limiting T cell exhaustion. Among naturally derived products significantly inhibiting HIV-1, the IND02-trimer is the first component demonstrating an entry inhibition property through binding to the viral envelope glycoprotein. These data suggest that cinnamon, a widely consumed spice, could represent a novel and promising candidate for a cost-effective, natural entry inhibitor for HIV-1 which can also down-modulate T cell exhaustion markers Tim-3 and PD-1.

PENERAPAN TEKNOLOGI VOIP UNTUK MENGOPTIMALKAN PENGGUNAAN JARINGAN INTRANET KAMPUS UNIVERSITAS UDAYANA

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Pande Ketut Sudiarta

2009-12-01

Full Text Available Jaringan intranet Universitas Udayana telah menghubungkan ketiga lokasi kampus, yaitu Kampus Bukit, Kampus Sudirman, dan Kampus Nias.  Lokasi kampus yang terpisah-pisah dan kampus Bukit yang memiliki area yang cukup luas memerlukan prasarana teleponi yang memadai.  Selama ini, komunikasi teleponi masih memanfaatkan provider seperti PT Telkom, walaupun komunikasi telepon hanya untuk komunikasi antar fakultas atau antar fakultas dengan rektorat di area kampus bukit.  Demikian juga untuk komunikasi telepon antar lokasi kampus yang berbeda. Walaupun beberapa fakultas dan juga gedung Rektorat memiliki perangkat PABX namun keberadaan kebanyakan hanya melayani komunikasi dalam satu gedung saja.  Pemanfaatan intranet kampus UNUD baru dimanfaatkan untuk akses Internet, akses Sistem Informasi dan untuk videoconference. Dengan beban trafik yang ada, jaringan intranet masih memungkinkan untuk dibebani dengan trafik yang lebih tinggi. Dengan demikian, untuk mengoptimalkan pemanfaatan bandwith,  diupayakan dengan mengembangakan sistem teleponi berbasis VoIP yang memanfaatkan infrastruktur yang ada. Tujuan yang ingin dicapai adalah menyediakan fasilitas telepon internal kampus yang tidak berbayar. Melalui teknologi VoIP ini,  komunikasi dapat dilakukan dengan beberapa cara baik menggunakan telepon analog maupun softphone yang dapat diinstall di masing-masing PC atau laptop. Hal ini nanti tentu akan memberikan efisiensi waktu bagi civitas karena mudah dihubungi dan secara langsung akan berdampak pada efisiensi biaya telekomunikasi di kampus. Infrastruktur yang dikembangkan menggunakan protokol SIP memanfaatkan Free Software Linux Fedora sebagai Operating System, Asterisk dan Ondo sebagai aplikasi server.  Di sisi pemakai, perangkat telepon dapat menggunakan dua model, pertama menggunakan softphone  yang ditujukan untuk personal dengan memanfaatkan nomor induk pegawai (NIP atau nomor induk mahasiswa (NIM sebagai nomor telepon. Model telepon ini aksesnya

Molecular identification, immunolocalization, and characterization of Clonorchis sinensis triosephosphate isomerase.

Science.gov (United States)

Zhou, Juanjuan; Liao, Hua; Li, Shan; Zhou, Chenhui; Huang, Yan; Li, Xuerong; Liang, Chi; Yu, Xinbing

2015-08-01

Clonorchis sinensis triosephosphate isomerase (CsTIM) is a key regulatory enzyme of glycolysis and gluconeogenesis, which catalyzes the interconversion of glyceraldehyde 3-phosphate to dihydroxyacetone phosphate. In this study, the biochemical characterizations of CsTIM have been examined. A full-length complementary DNA (cDNA; Cs105350) sequence encoding CsTIM was obtained from our C. sinensis cDNA library. The open reading frame of CsTIM contains 759 bp which encodes 252 amino acids. The amino acid sequence of CsTIM shares 60-65% identity with other species. Western blot analysis displayed that recombinant CsTIM (rCsTIM) can be probed by anti-rCsTIM rat serum and anti-C. sinensis excretory/secretory products (anti-CsESPs) rat serum. Quantitative reverse transcription (RT)-PCR and western blotting analysis revealed that CsTIM messenger RNA (mRNA) and protein were differentially expressed in development cycle stages of the parasite, including adult worm, metacercaria, excysted metacercaria, and egg. In addition, immunolocalization assay showed that CsTIM was located in the seminal vesicle, eggs, and testicle. Moreover, rCsTIM exhibited active enzyme activity in catalytic reactions. The Michaelis constant (K m) of rCsTIM was 0.33 mM, when using glyceraldehyde 3-phosphate as the substrate. The optimal temperature and pH of CsTIM were 37 °C and 7.5-9.5, respectively. Collectively, these results suggest that CsTIM is an important protein involved in glycometabolism, and CsTIM possibly take part in many biological functions in the growth and development of C. sinensis.

T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production.

Science.gov (United States)

Kim, Hye Sung; Kim, Hyun Soo; Lee, Chang Woo; Chung, Doo Hyun

2010-04-15

The T cell Ig domain and mucin domain (TIM)1 protein expressed on the surface of Th2 cells regulates the immune response by modulating cytokine production. However, the functional roles of TIM1 have not been examined in NKT cells. Therefore, we investigated the immunologic effects of TIM1 on NKT cells. We found that mouse NK1.1(+)TCR-beta(+), alpha-galactosyl ceramide/CD1d dimer(+) NKT, and NKT hybridoma (DN32.D3) cells constitutively express TIM1 and TIM4 on their surface. Engagement of TIM1 on NKT cells by any of several anti-TIM1 mAbs suppressed the production of IFN-gamma in the presence of TCR stimulation in vitro and in vivo, whereas the effects of such engagement on Th2 cytokine production by the NKT cells varied with the particular anti-TIM1 Ab clone. Moreover, in DN32.D3 TIM4-knockdown NKT hybridoma cells, TIM1 engagement by rTIM1 or TIM4 enhanced IL-4 production while inhibiting IFN-gamma production in the presence of alpha-galactosyl ceramide stimulation. TIM1 engagement increased GATA-3 expression but reduced T-bet expression in NKT cells in the presence of TCR engagement. The adoptive transfer of NKT cells preincubated with anti-TIM1 mAbs into Jalpha18(-/-) mice aggravated bleomycin-induced pulmonary fibrosis by suppressing IFN-gamma production. Taken together, these results suggest that TIM1 costimulation on NKT cells enhances the cellular production of IL-4 while inhibiting the production of IFN-gamma. Thus, as a differential regulator of the immune response, TIM1 on NKT cells may be a useful therapeutic target for immune diseases.

IMPLEMENTASI AUGMENTED REALITY UNTUK IDENTIFIKASI LOGO DAN VIDEO SEBAGAI MEDIA INFORMASI MENGGUNAKAN METODE KLASIFIKASI NAIVE BAYESIAN

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Astrid Novita Putri

2018-04-01

Full Text Available Pada  Universitas Semarang Fakultas Teknologi Informasi dan  Komunikasi setiap  tahun  selalu mempunyai banyak kegiatan seperti kegiatan Seminar, Workshop, Pelatihan, Festifal, dsb. Kegiatan- kegiatan  tersebut  biasanya   didokumentasikan  dalam  bentuk  foto   dan   video.   Sedangkan  untuk dokumentasi publikasi kegiatan dalam bentuk media promosi maupun media informasi belum dilakukan, sehingga masyarakat umum yang kurang familiar tidak dapat mengetahui informasi dengan kegiatan yang ada. Memanfaatkan aplikasi smartphone yang berbasis android, blackberry, dan iphone dapat menggunakan  salah  satu  teknologi  augmented  reality  3D  yang  berfungsi  untuk  mengidentifikasi informasi melalui logo Fakultas TIK dan menerapkannya pada berbagai media cetak atau elektronik. Sehingga dengan adanya perubahan cara promosi tersebut diharapkan dapat menarik minat perhatian masyarakat umum dan masyarakat umum untuk mengetahui informasi mengenai kegiatan di Universitas Semarang khususnya Fakultas Teknologi Informasi dan Komunikasi. Pada penelitian ini, akan membahas bagaimana mengklasifikasikan kegiatan-kegiatan tersebut menggunakan metode naive bayes   menjadi dua  kategori yaitu favorit atau tidak favorit. Berdasarkan data foto dan video kegiatan FTIK tahun 2017 yang telah diimplementasikan menggunakan tools Unity 3D menunjukkan bahwa penerapan Augmented Reality untuk identifikasi logo sebagai media informasi menggunakan metode klasifikasi naive bayes dapat diimplementasikan dengan baik. Diharapkan dengan adanya klasifikasi kegiatan dengan memanfaatkan teknologi  augmented  reality  yang  diimplementasikan menggunakan  tools  Unity  3D, informasi yang dihasilkan akan lebih informatif dan menarik perhatian masyarakat umum.   Kata kunci: augmented, reality, naive, bayesian, kegiatan.

Implementasi Sistem Jaminan Mutu (Quality Assurance Proses Pembelajaran di Perguruan Tinggi

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Ari Basuki

2004-06-01

Full Text Available Penelitian ini bertujuan untuk memonitor implementasi sistem jaminan mutu (Quality Assurance proses pembelajaran jenjang SI di Jurusan Manajemen Fakultas Ekonomi Unhrersitas Gadjah Mada. Fokus penelitian melipuri proses pelaksanaan, problema yang dihadapi, serta dampak atau perubahan yang dihasilkannya. Model penelitian yang digunakan ialah monitoring kebijakan yang diadopsi dan teori William N. Dunn. Teknik pengumpulan data dilakukan dengan wawancara, dokumentasi, dan kuesioner. Responden yang dipilih dalam penelitian ini ialah Wakil Dekan Bidang Akademik Fakultas Ekonomi UGM, Ketua Jurusan Manajemen, Direktur Eksekutif QUE-Project Jurusan Manajemen, Dosen Jurusan Manajemen, para Kepala Sub Bagian, serta 200 mahasiswa Jurusan Manajemen yang dipilih secara acak. Teknik analisis data dilakukan dengan sajian tabel, sajian grafik, dalam hubungannya dengan fungsi monitor­ing yaittu compliance (kepatuhan, eksplanasi, auditing (pemeriksaan, dan akuntansL Temuan pokok dalam penelitian ini ialah pelaksanaan sistem jaminan mutu proses pembelajaran di Jurusan Manajemen Fakultas Ekonomi UGM secara eksplisit dimulai sejak Jurusan ini menerima dukungan dana QUE-Project pada tahun 1998. Pelaksanaan program berjalan dan berhasil baik karena komitmen para pelaku, manajemen bagus dengan indikator yang bisa diukur, dan dukungan dana yang memadai. Dampak positif yang terjadi antara lain: (1 terciptanya kultur organisasi yang makin kondusif, (2 peningkatan mutu kinerja dosen, (3 mutu proses pembelajaran yang cukup baik, dan (4 tingkat kepuasan mahasiswa yang cukup tinggL Adapun problema yang dihadapi antara lain: (1 keterbatasan SDM karena cukup banyaknya dosen yang sedang menempuh studi lanjut, dan (2 tidak mudahnya mengintegrasikan antara penilaian kinerja dengan reward and punishment system. Kata kunci: sistem jaminan mutu, pembelajarun diperguruan tinggL

Multicenter, Randomized, Controlled Study Comparing Tafluprost/Timolol Fixed Combination with Latanoprost/Timolol Fixed Combination in Primary Open-Angle Glaucoma and Ocular Hypertension.

Science.gov (United States)

Suzuki, Katsuyoshi; Otsuka, Naomi; Hizaki, Hiroko; Hashimoto, Masayo; Kuwayama, Yasuaki

2018-06-05

This was the first exploratory randomized controlled study to compare the efficacy and safety of a preserved tafluprost/timolol fixed combination (TAF/TIM) with a preserved latanoprost/timolol fixed combination (LAT/TIM). This prospective, randomized, open-label study was conducted in Japanese patients with primary open-angle glaucoma, including normal-tension glaucoma or ocular hypertension. Following a 4-week LAT/TIM run-in period, eligible patients entered a 12-week treatment period, during which they received either LAT/TIM or TAF/TIM. The efficacy endpoint was the change in intraocular pressure (IOP) from baseline to week 12 and the safety endpoints included the changes from baseline to week 12 in superficial punctate keratopathy (SPK) score, tear breakup time (TBUT), and hyperemia score, as well as adverse events (AEs). At week 6, ocular symptoms were evaluated using a questionnaire. In total, 131 patients provided informed consent. Of these, 115 completed the run-in period and were assigned to receive TAF/TIM (n = 60) or LAT/TIM (n = 55). At week 12, there were no significant differences between the TAF/TIM and LAT/TIM groups in the change from baseline in trough IOP and IOP at 4-6 h after instillation. There were no significant differences between the two groups in the change from baseline to week 12 in SPK score, TBUT, and hyperemia score. However, only in the TAF/TIM group, the total SPK score and the inferior cornea SPK score were significantly lower at week 12 compared with baseline. Eye irritation and eye pain were significantly decreased in the TAF/TIM group compared with the LAT/TIM group. Two treatment-related AEs were reported in the TAF/TIM group (3.3%) and none in the LAT/TIM group, while no serious AEs were reported in either group. TAF/TIM is as effective as LAT/TIM in terms of IOP-reducing effect, with fewer ocular symptoms. TAF/TIM was associated with a significant improvement in SPK scores. UMIN Clinical Trials Registry Identifier

Nepodmíněný základní příjem a práce

Czech Academy of Sciences Publication Activity Database

Hrubec, Marek; Brabec, Martin

-, č. 1 (2014), s. 49-53 ISSN 1804-3070 Institutional support: RVO:67985955 Keywords : Universal * unconditional * basic income * work * labour Subject RIV: AO - Sociology, Demography http://www.ff.cuni.cz/fakulta/vydavatelstvi/casopisy-a-rocenky-ff-uk/forum-socialni-prace-social-work-forum/#8

Efficacy and tolerability of fixed-combination bimatoprost/timolol versus fixed-combination dorzolamide/brimonidine/timolol in patients with primary open-angle glaucoma or ocular hypertension: a multicenter, prospective, crossover study.

Science.gov (United States)

García-López, Alfonso; Paczka, José A; Jiménez-Román, Jesús; Hartleben, Curt

2014-12-19

Fixed-combination ocular hypotensives have multiple advantages, but triple-therapy dorzolamide/brimonidine/timolol (dorz/brim/tim) is only available in Latin and South America, and information on its relative efficacy is limited. This study compares the efficacy and tolerability of fixed-combination bimatoprost/timolol (bim/tim) and dorz/brim/tim in Mexican patients with primary open-angle glaucoma or ocular hypertension. In this investigator-masked, crossover study, patients with unmet target intraocular pressure (IOP) on once-daily bim/tim or twice-daily dorz/brim/tim received the opposite medication for 3 months before returning to their pre-baseline medication for 3 months. IOP was evaluated before and after morning instillation at months 2, 3, 5 and 6. Primary endpoints were mean IOP change and Ocular Surface Disease Index© (OSDI) score at each visit. The intent-to-treat population was the a priori analysis population, but due to the number of discontinuations, the per-protocol and intent-to-treat populations were used for the primary efficacy and sensitivity analyses, respectively. Seventy-eight and 56 patients were included in the intent-to-treat and per-protocol populations, respectively. At month 3, statistically significant IOP reductions from baseline were observed in the bim/tim (P < 0.01) and dorz/brim/tim (P < 0.0001) groups, regardless of assessment time. At month 6, patients returned to bim/tim exhibited no significant IOP increase (regardless of assessment time), but patients returned to dorz/brim/tim exhibited a statistically significant IOP increase (P < 0.001) when assessed before instillation of study treatment. Results were similar in both intent-to-treat and per-protocol analysis populations. In the per-protocol analysis, 70% of patients on bim/tim at month 3 had an IOP <14 mm Hg, which declined to 58% (P = 0.0061) at month 6 (ie, after 3 months of dorz/brim/tim treatment). In patients receiving dorz/brim/tim at month 3

A teoria da pessoa de Tim Ingold: mudança ou continuidade nas representações ocidentais e nos conceitos antropológicos?

Directory of Open Access Journals (Sweden)

Regina Coeli Machado e Silva

2011-06-01

Full Text Available O objetivo deste artigo é discutir a proposta analítica de Tim Ingold para compreender a noção de pessoa, que pretende superar a dualidade mente/corpo. Essa dualidade é "repensada" através da objeção ao conceito de "representação coletiva", em favor de uma abordagem que incorpora elementos biológicos na explicação, concebendo a noção de pessoa como um aspecto da vida orgânica. O argumento aqui desenvolvido é que a incorporação desses princípios como uma tentativa de superar o dualismo mente/corpo nos obriga a enfrentar de modo renovado as questões aí colocadas, mas questiona se o resultado não seria reiterar explicações das propostas analíticas que quer refutar. Isto é, a base epistemológica da escola sociológica francesa que postula o fundamento social da cognição. Para isso, este artigo está organizado em três partes. A primeira, introdutória, apresenta o contexto social recente e o desenvolvimento das ciências cognitivas como condições propiciadoras da retomada do tema em questão. A segunda apresenta a perspectiva analítica de Ingold para compreender a noção de pessoa que, ao mesmo tempo, pretende ultrapassar dualismos como natureza e cultura, mente e corpo. Finalmente, na terceira parte, discute as implicações teóricas e ideológicas do argumento analítico proposto por IngoldThe aim of this paper is to discuss the analytical proposition of Tim Ingold in understanding the notion of Person who wants to overcome the duality of mind and body. This duality is "rethought" through the objection to the concept of "collective representation", in favor of an approach that incorporates biological principles in explaining, to conceive the person as an aspect of organic life in general. The argument developed here is that the incorporation of these principles as an attempt to overcome the mind / body dualism forces us to confront the issues in a new way. And it also questions whether the result would not renew

Annual report Foundation Flora Malesiana 1992

NARCIS (Netherlands)

Roos, M.C.

1993-01-01

Second Flora Malesiana Symposium — The highlight of the year was the Second Flora Malesiana Symposium. It was organized under the auspices of the Foundation Flora Malesiana (FFM) by Puslitbang Biologi of the Indonesian Institute of Sciences (LIPI) and the Fakultas Biologi of the Gadjah Mada

Uralic numerals : is the evolution of numeral system reconstructable? : (Reading new Václav Balzhek's book on numerals in Eurasia) / Vladimir Napolskich

Index Scriptorium Estoniae

Napolskich, Vladimir

2003-01-01

Rmt.: Balzhek, Václav. Numerals. Comparative-etymological analyses of numeral systems and their implications (saharan, nubian, egyptian, berber, kartvelian, ralic, altaic and indo-european languages). Brno, 1999. (Spisy Masarykovy Univerzity v Brné. Filozofická fakulta; 322). Ülevaade uurali keelte arvsõnu käsitlevast osast

Growth of Czech Breastfed Infants in Comparison with the World Health Organization Standards

Czech Academy of Sciences Publication Activity Database

Vignerová, J.; Shriver, L.; Paulová, M.; Brabec, Marek; Schneidrová, D.; Růžková, R.; Procházka, B.; Riedlová, J.

2015-01-01

Roč. 23, č. 1 (2015), s. 32-38 ISSN 1210-7778 Grant - others:GA MZd(CZ) NS9974; Pedagogická fakulta UK(CZ) PRVOUK P02 Institutional support: RVO:67985807 Keywords : breastfeeding * Czech * growth standards * infants * national references * WHO standards Subject RIV: FG - Pediatrics Impact factor: 0.525, year: 2015

Timing of metamorphism and exhumation in the Nordøyane ultra-high-pressure domain, Western Gneiss Region, Norway: New constraints from complementary CA-ID-TIMS and LA-MC-ICP-MS geochronology

Science.gov (United States)

Butler, J. P.; Jamieson, R. A.; Dunning, G. R.; Pecha, M. E.; Robinson, P.; Steenkamp, H. M.

2018-06-01

We present the results of a combined CA-ID-TIMS and LA-MC-ICP-MS U-Pb geochronology study of zircon and associated rutile and titanite from the Nordøyane ultra-high-pressure (UHP) domain in the Western Gneiss Region (WGR) of Norway. The dated samples include 4 eclogite bodies, 2 host-rock migmatites, and 2 cross-cutting pegmatites and leucosomes, all from the island of Harøya. Zircon from a coesite eclogite yielded an age of ca. 413 Ma, interpreted as the time of UHP metamorphism in this sample. Zircon data from the other eclogite bodies yielded metamorphic ages of ca. 413 Ma, 407 Ma, and 406 Ma; zircon trace-element data associated with 413 Ma and 407 Ma ages are consistent with eclogite-facies crystallization. In all of the eclogites, U-Pb dates from zircon cores, interpreted as the times of protolith crystallization, range from ca. 1680-1586 Ma, consistent with Gothian ages from orthogneisses in Nordøyane and elsewhere in the WGR. A zircon core age of ca. 943 Ma from one sample agrees with Sveconorwegian ages of felsic gneisses and pegmatites in the western part of the area. Migmatites hosting the eclogite bodies yielded zircon core ages of ca. 1657-1591 Ma and rim ages of ca. 395-392 Ma, interpreted as the times of Gothian protolith formation and Scandian partial melt crystallization, respectively. Pegmatite in an eclogite boudin neck yielded a crystallization age of ca. 388 Ma, interpreted as the time of melt crystallization. Rutile and titanite from 3 samples (an eclogite and two migmatites) yielded concordant ID-TIMS ages of 378-376 Ma. The results are similar to existing U-Pb data from other Nordøyane eclogites (415-405 Ma). In combination with previous pressure-temperature data from the coesite eclogite, these ages indicate that peak metamorphic conditions of 3 GPa/760 °C were reached ca. 413 Ma, followed by decompression to 1 GPa/810 °C by ca. 397 Ma and cooling below ca. 600 °C by ca. 375 Ma. The results are compatible with protracted UHP

Implementasi Undang-Undang No 6 Tahun 2014 Tentang Desa di Desa Tempel Kecamatan Wedung Kabupaten Demak

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Nur Faizah

2017-08-01

Full Text Available Tujuan penelitian ini adalah untuk mengetahui dan menggambarkan bagaimana implementasi Undang-Undang No 6 Tahun 2014 tentang Desa serta untuk mengidentifikasi kendalanya di Desa Tempel. Analisis data menggunakan metode analisis Miles dan Huberman. Teori yang digunakan adalah model implementasi George C. Edward III. Hasil penelitian diketahui bahwa Implementasi Undang-Undang Nomor 6 Tahun 2014 Tentang di Desa Tempel dilihat dari aspek komunikasi, telah dilakukan komunikasi dengan baik antara pelaksana kebijakan (Pemerintah Desa dengan sasaran kebijakan (Masyarakat Desa, dari aspek sumberdaya yaitu sumberdaya Pemerintah Desa Tempel yang belum mendukung, dari aspek sikap pelaksana, implementor menyatakan tanggungjawab dan komitmennya untuk pelaksanaan kebijakan Undang-undang Nomor 6 Tahun 2014 Tentang Desa, dan struktur birokrasi belum memenuhi syarat secara efektif. Kendala-Kendala yang dihadapi oleh Pemerintah Desa Tempel yaitu pada aspek komunikasi belum ada tindak lanjut dari perwakilan desa yang pernah mengikuti sosialisasi, pembekalan dan pelatihan kepada perangkat desa lainnya. Pada aspek sikap pelaksana yaitu kurangnya respon dari masyarakat yang menganggap kebijakan tersebut hanya sebuah kebijakan rutin belaka, maka diperlukan sikap tanggungjawab yang tinggi dari implementor. The purpose of this study was to determine and describe how the implementation of Law No. 6 of 2014 on the village as well as to identify barriers in the village of Tempel. Analysis of data using analytical methods Miles and Huberman. The theory used is the model of George C. Edward III implementation. The survey results revealed that the implementation of Law No. 6 of 2014 About Village Tempel seen from the aspect of communication, has done good communication between the implementers (village government with policy targets (Rural Community, from the aspect of resource that government resources Desa Paste not support, from the aspect of attitude executor, implementor

IPTEKS BAGI MASYARAKAT USAHA JASA TAILOR DI KOTA SEMARANG

Directory of Open Access Journals (Sweden)

Sri Endah Wahyuningsih

2016-03-01

Full Text Available Tujuan kegiatan Ipteks bagi Masyarakat (IbM ini adalah untuk menyelesaikan permasalahan yang dihadapi oleh industri kecil jasa penjahitan busana pria dan wanita di Kecamatan Gajah Mungkur, Kota Semarang. Ada dua usaha jasa tailor yang diprioritaskan menjadi mitra IbM, yaitu Bapak Mamiek Slamet dan Ibu Sri Astuti Yudhaningrum dengan dua aspek permasalahan yang akan ditangani, yaitu aspek produksi dan aspek manajemen. Target khusus yang ingin dicapai adalah, dalam aspek produksi : 1 Dihasilkan 2 sofware pemrograman data pelanggan purnama dan dara tailor mengenai : identitas pelanggan, jenis dan ukuran pelanggan untuk model kebaya, kemeja, jas, celana dan rok, serta ongkos jahit 2 pelatihan Penggunaan mesin high speed untu produksi celana, kemeja maupun blazer 3 Menambah peralatan produksi, antara mesin jahit industri 4 Tempat material dan produk lebih tertata sehingga lebih nyaman, aman bersih, dan rapi. Dalam aspek manajemen: 1 Pembukuan data identitas, ukuran dan model baju pesanan tersimpan dalam komputer sehingga lebih cepat mencari dan mempercepat layanan lebih baik , pencatatan ongkos jahit dan keuangan lebih tertib 2 Terdapat nota sesuai identitas dan kartu nama tempat produksi. Sebagai tim pelaksana kegiatan ini melibatkan dosen dan mahasiswa dengan bidang keahlian yang sesuai dengan kebutuhan lapangan. Dalam pelaksanaan dipakai beberapa metode yang saling mendukung, antara lain dengan ceramah/ penyuluhan untuk materi yang bersifat teori dan motivasi, demonstrasi/peragaan untuk menyampaikan materi praktek/keterampilan, praktek langsung oleh mitra, dan pendampingan kegiatan. Luaran pengabdian dalam aspek produksi : 1 Dihasilkan 2 sofware pemrograman data pelanggan purnama dan dara tailor mengenai : identitas pelanggan, jenis dan ukuran pelanggan untuk model kebaya, kemeja, jas, celana dan rok, serta ongkos jahit 2 pelatihan Penggunaan mesin high speed untu produksi celana, kemeja maupun blazer 3 Menambah peralatan produksi, antara mesin

KEEFEKTIFAN PELAKSANAAN PRINSIP PENDIDIKAN SISTEM GANDA SMKN 1 PANGKALAN KERINCI DAN SMKN 1 UKUI KABUPATEN PELALAWAN

Directory of Open Access Journals (Sweden)

Rika Ariani

2014-09-01

Full Text Available Penelitian ini bertujuan untuk mengetahui keefektifan pelaksanaan prinsip Pendidikan Sistem Ganda (PSG di SMKN 1 Pangkalan Kerinci dan SMKN 1 Ukui ditinjau dari sisi (1 konteks, (2 input, (3 proses dan (4 produk/hasil. Metode penelitian yang digunakan adalah studi evaluasi dengan analisis deskriptif kuantitatif, dengan menggunakan metode CIPP (Context, Input, Process, Product dari Stufflebeam. Subyek penelitian adalah kepala sekolah, wakil kepala sekolah urusan Dunia Usaha dan Industri (Humas, wakil kepala sekolah urusan kurikulum, ketua jurusan masing-masing prodi, guru, dan 123 siswa yang telah melaksanakan PSG untuk jurusanTeknik Komputer Jaringan, Teknik Sepeda Motor, dan Teknik Kendaraan Bermotor. Pengumpulan data dilakukan dengan wawancara, observasi, dan kuesioner. Hasil penelitian ini menunjukan dari sisi (1 konteks: organisasi pelaksana/manajemen program pelaksanaan PSG sudah terstruktur, relevansi program PSG sudah cukup relevan dengan skill dan jurusan siswa, dan secara keseluruhan variable konteks ini sangat efektif, (2 input: pengelolaan peserta pelaksana PSG, tenaga kependidikan, kurikulum, sarana dan prasarana PSG, dan pembiayaan PSG telah terkelola dengan baik, dan variabel input sudah efektif, (3 proses: proses persiapan pelaksanaan PSG di sekolah sudah terorganisir dengan baik, namum proses pelaksanaan PSG oleh siswa pada Dunia Usaha dan Dunia Industri tidak terlaksana sepenuhnya seperti yang telah diprogramkan, dan pada umumnya variabel proses sudah efektif, (4 aspek hasil kemanfaatan pelaksanaan PSG telah meningkatkan rasa percaya diri siswa dalam menghadapi Ujian Nasional dan meningkatkan kemampuan siswa dibidangnya dan variabel produk sangat efektif.

Analisis Komparatif Pelayanan Akademik Pada Fakultas Ekonomi Dan Fakultas ISIP Universitas Jenderal Achmad Yani

Directory of Open Access Journals (Sweden)

Nita Yura Roslina

2015-10-01

Full Text Available Upgrading of skills as well as knowledge to make a new generation of high quality to be able to pursue and develop science and technology are regarded as a catalyst of economic progress that will improve people's welfare. Therefore, the college has an ethical responsibility to the quality of its graduates as work ability, creativity, community recognition as an absorber of human resources towards credibility. Private universities are faced with tight competition and should do anticipate to explore and improve all aspects of service that are owned, including in terms of academic services. Academic services can be interpreted as an attempt by the college to provide facilities to meet the needs of students in matters related to academic activities. This study aims to find out, observe, assess and analyze whether there are significant differences anatara academic services students of the Faculty of Economics and the Faculty of Social and Political Sciences University General Achmad Yani. In this study took a sample of 149 students of the Faculty of Economics and 143 students from the Faculty of Social and Political Sciences Unjani.The method of analysis used to answer the hypothesis is to use parametric statistics that comparative analysis with t test (t-test. The results of his research is the average score of students of the Faculty of Economics Unjani to attribute academic services at 73.7% (relatively high compared to the average score of students of the Faculty of Social and Political Sciences of the attributes of academic services amounted to 72.6% (high enough. The difference score of 1.2% illustrate the difference. Results of calculation with the formula t-test separated sample variance relation is independent (uncorrelated and the second variant sample is not homogeneous, known F count larger than F table (1.3> 1,271. Based on calculations by comparing t arithmetic with t table known that t t table amounted to -1.79 -0.7047 with a standard error of 7.5% (0.075, thus there are significant differences on the attributes of academic services between the students of the Faculty of Economics with the students of the Faculty of Social Sciences and Political University General Achmad Yani.

Reliability of thermal interface materials: A review

International Nuclear Information System (INIS)

Due, Jens; Robinson, Anthony J.

2013-01-01

Thermal interface materials (TIMs) are used extensively to improve thermal conduction across two mating parts. They are particularly crucial in electronics thermal management since excessive junction-to-ambient thermal resistances can cause elevated temperatures which can negatively influence device performance and reliability. Of particular interest to electronic package designers is the thermal resistance of the TIM layer at the end of its design life. Estimations of this allow the package to be designed to perform adequately over its entire useful life. To this end, TIM reliability studies have been performed using accelerated stress tests. This paper reviews the body of work which has been performed on TIM reliability. It focuses on the various test methodologies with commentary on the results which have been obtained for the different TIM materials. Based on the information available in the open literature, a test procedure is proposed for TIM selection based on beginning and end of life performance. - Highlights: ► This paper reviews the body of work which has been performed on TIM reliability. ► Test methodologies for reliability testing are outlined. ► Reliability results for the different TIM materials are discussed. ► A test procedure is proposed for TIM selection BOLife and EOLife performance.

U.S. Tsunami Information technology (TIM) Modernization:Developing a Maintainable and Extensible Open Source Earthquake and Tsunami Warning System

Science.gov (United States)

Hellman, S. B.; Lisowski, S.; Baker, B.; Hagerty, M.; Lomax, A.; Leifer, J. M.; Thies, D. A.; Schnackenberg, A.; Barrows, J.

2015-12-01

Tsunami Information technology Modernization (TIM) is a National Oceanic and Atmospheric Administration (NOAA) project to update and standardize the earthquake and tsunami monitoring systems currently employed at the U.S. Tsunami Warning Centers in Ewa Beach, Hawaii (PTWC) and Palmer, Alaska (NTWC). While this project was funded by NOAA to solve a specific problem, the requirements that the delivered system be both open source and easily maintainable have resulted in the creation of a variety of open source (OS) software packages. The open source software is now complete and this is a presentation of the OS Software that has been funded by NOAA for benefit of the entire seismic community. The design architecture comprises three distinct components: (1) The user interface, (2) The real-time data acquisition and processing system and (3) The scientific algorithm library. The system follows a modular design with loose coupling between components. We now identify the major project constituents. The user interface, CAVE, is written in Java and is compatible with the existing National Weather Service (NWS) open source graphical system AWIPS. The selected real-time seismic acquisition and processing system is open source SeisComp3 (sc3). The seismic library (libseismic) contains numerous custom written and wrapped open source seismic algorithms (e.g., ML/mb/Ms/Mwp, mantle magnitude (Mm), w-phase moment tensor, bodywave moment tensor, finite-fault inversion, array processing). The seismic library is organized in a way (function naming and usage) that will be familiar to users of Matlab. The seismic library extends sc3 so that it can be called by the real-time system, but it can also be driven and tested outside of sc3, for example, by ObsPy or Earthworm. To unify the three principal components we have developed a flexible and lightweight communication layer called SeismoEdex.

Penerapan Penjadwalan Probabilistik Menggunakan Simulasi Monte Carlo Pada Proyek Pembangunan Gedung Giant Extra Pettarani

OpenAIRE

Nasruddin

2017-01-01

PENERAPAN PENJADADWALAN PROBABILISTIK MENGGUNAKAN SIMULASI MONTE CARLO PADA PEMBANGUNAN GEDUNG GIANT EXTRA PETTARANI Nasruddin Jurusan Teknik Sipil Fakultas Teknik Universitas Hasanuddin Jalan Poros Malino Km 6 Bontomarannu,92172 Gowa, Sulawesi Selatan ??? Indonesia E-mail : ABSTRAK Dalam bidang manajemen proyek, simulasi Monte Carlo digunakan untuk menghitung atau mengiterasi biaya dan waktu sebuah proyek dengan menggunakan nilai - nilai yang...

Persepsi Mahasiswa Program Pascasarjana Terhadap Database Science Direct Pada Perpustakaan Universitas Sumatera Utara

OpenAIRE

Purba, Artita Wati Dorma

2017-01-01

120709051 Purba, Artita Wati Dorma. 2017. Persepsi Mahasiswa Program Pascasarjana terhadap Database Science Direct pada Perpustakaan Universitas Sumatera Utara. MEDAN: Program Studi Ilmu Perpustanaan, Fakultas Ilmu Budaya, Universitas Sumatera Utara Penelitian ini bertujuan untuk mengetahui bagaimanakah persepsi mahasiswa program Pascasarjana terhadap Database Science Direct pada Perpustakaan Universitas Sumatera Utara. Penelitian ini menggunakan metode deskriptif dengan pendekatan kuan...

KEBIJAKAN POLITIK LUAR NEGERI FILIPINA PADA MASA PEMERINTAHAN RODRIGO DUTERTE TENTANG LAUT CINA SELATAN

OpenAIRE

BEATRICE G. P., JENNIFER

2017-01-01

2017 Jennifer Beatrice Glorianna Putri, E131 13 308. ???Kebijakan Politik Luar Negeri Filipina Pada Masa Pemerintahan Rodrigo Duterte tentang Laut Cina Selatan???, dibawah bimbingan Patrice Lumumba, selaku Pembimbing I, dan Aswin Baharuddin, selaku Pembimbing II, pada Jurusan Ilmu Hubungan Internasional, Fakultas Ilmu Sosial dan Ilmu Politik, Universitas Hasanuddin. Penelitian ini bertujuan untuk mendeskripsikan kebijakan politik luar negeri Filipi...

PERBANDINGAN PARTISIPASI PEREMPUAN DALAM POLITIK DI INDONESIA DAN MALAYSIA

OpenAIRE

NIRFADILAH, SITI MEUTHIA

2015-01-01

2015 Siti Meuthia Nurfadilah, E131 11 006, Skripsi yang berjudul : Perbandingan Partisipasi Perempuan dalam Politik di Indonesia dan Malaysia, dibawah bimbinganDrs. Patrice Lumumba, MAselaku pembimbing I danNur Isdah S.IP, MAsebagai pembimbing II, Jurusan Ilmu Hubungan Internasional, Fakultas Ilmu Sosial dan Ilmu Politik, Universitas Hasanuddin. Penulisan skripsi ini bertujuan untuk memberikan gambaran umum mengenai perbandingan partisipasi ...

Pengaruh Ekstrak Alang-alang, Babadotan dan Teki terhadap Penyakit Antraknosa pada Buah Pisang Kultivar Cavendish

OpenAIRE

Intan Zahara Arie; Joko Prasetyo; Efri Efri

2015-01-01

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak alang-alang (Imperata cylindrica), teki (Cyperus rotundus), dan babadotan (Ageratum conyzoides) terhadap pertumbuhan dan sporulasi Colletotrichum musae. Penelitian juga bertujuan mengetahui pengaruh ekstrak alang-alang, teki dan babadotan terhadap keparahan penyakit antraknosa secara in vivo.Penelitian dilaksanakan di Laboratorium Penyakit Tumbuhan, Fakultas Pertanian, Universitas Lampung, dari bulan Juni sampai dengan September 2014....

Pengaruh Pemberian Cendawan Endofit Asal Tanaman Kelapa Sawit Terhadap Pertumbuhan Kelapa Sawit Pada Tanah Terinfeksi Ganoderma Spp.

OpenAIRE

Kurniawan, Rendi; pinem, Mukhtar iskandar; lisnawita, lisnawita

2017-01-01

Penggunaan mikroorganisme antagonis merupakan salah satu alternatif pencegahan penyakit busuk pangkal batang yang disebabkan oleh Ganodermaspp. pada perkebunan kelapa sawit. Penelitian ini bertujuan untuk mendapatkan cendawan endofit asal tanaman kelapa sawit yang berpotensi sebagai agens biokontroluntuk mengendalikan Ganodermapadapembibitan kelapa sawit. Penelitian dilaksanakan di Rumah Kaca Fakultas Pertanian USU pada Juni 2015 sampai Januari 2016 menggunakanRancanganAcakKelompoknon faktori...

Clay minerals in uraniferous deposit of Imouraren (Tim Mersoi basin, Niger): implications on genesis of deposit and on ore treatment process

International Nuclear Information System (INIS)

Billon, Sophie

2014-01-01

Nigerian uraniferous deposits are located in carboniferous and Jurassic formations of Tim Mersoi basin. AREVA is shareholder of 3 mine sites in this area: SOMAIR and COMINAK, both in exploitation since 1960's and IMOURAREN, 80 km further South, whose exploitation is planned for 2015. Mineralization of Imouraren deposit is included in the fluvial formation of Tchirezrine 2 (Jurassic), composed of channels and flood plains. Facies of channel in-fillings range from coarse sandstones to siltstones, while overflow facies are composed of analcimolites. Secondary mineralogy was acquired during 2 stages: 1- diagenesis, with formation of clay minerals, analcime, secondary quartz and albites, and 2- stage of fluids circulations, which induced alteration of detrital and diagenetic minerals, formation of new phases and uranium deposition. A mineralogical zoning, at the scale of deposit resulted from this alteration. The heterogeneity of Tchirezrine 2, at the level of both facies and mineralogy, is also evidenced during ore treatment, as ore reacts differently depending on its source, with sometimes problems of U recovery. Ore treatment tests showed that analcimes and chlorites were both penalizing minerals, because of 1- the sequestration of U-bearing minerals into analcimes, 2- their dissolution which trends to move away from U solubilization conditions (pH and Eh) and to form numerous sulfates, and 3- problems of percolation. A detection method of analcime-rich ores, based on infrared spectroscopy, was developed in order to optimize ore blending and so to reduce negative effects during ore treatment process. (author)

Cyclic lipopeptide signature as fingerprinting for the screening of halotolerant Bacillus strains towards microbial enhanced oil recovery.

Science.gov (United States)

Farias, Bárbara C S; Hissa, Denise C; do Nascimento, Camila T M; Oliveira, Samuel A; Zampieri, Davila; Eberlin, Marcos N; Migueleti, Deivid L S; Martins, Luiz F; Sousa, Maíra P; Moyses, Danuza N; Melo, Vânia M M

2018-02-01

Cyclic lipopeptides (CLPs) are non-ribosomal biosurfactants produced by Bacillus species that exhibit outstanding interfacial activity. The synthesis of CLPs is under genetic and environmental influence, and representatives from different families are generally co-produced, generating isoforms that differ in chemical structure and biological activities. This study to evaluate the effect of low and high NaCl concentrations on the composition and surface activity of CLPs produced by Bacillus strains TIM27, TIM49, TIM68, and ICA13 towards microbial enhanced oil recovery (MEOR). The strains were evaluated in mineral medium containing NaCl 2.7, 66, or 100 g L -1 and growth, surface tension and emulsification activity were monitored. Based on the analysis of 16S rDNA, gyrB and rpoB sequences TIM27 and TIM49 were assigned to Bacillus subtilis, TIM68 to Bacillus vallismortis, and ICA13 to Bacillus amyloliquefaciens. All strains tolerated up to 100-g L -1 NaCl, but only TIM49 and TIM68 were able to reduce surface tension at this concentration. TIM49 also showed emulsification activity at concentrations up to 66-g L -1 NaCl. ESI-MS analysis showed that the strains produced a mixture of CLPs, which presented distinct CLP profiles at low and high NaCl concentrations. High NaCl concentration favored the synthesis of surfactins and/or fengycins that correlated with the surface activities of TIM49 and TIM68, whereas low concentration favored the synthesis of iturins. Taken together, these findings suggest that the determination of CLP signatures under the expected condition of oil reservoirs can be useful in the guidance for choosing well-suited strains to MEOR.

Fakultas Ekonomi Universitas Muhammadiyah Surakarta

Directory of Open Access Journals (Sweden)

Wuryaningsih DL Wuryaningsih DL

2013-12-01

because the value of the current ratio is less than 200% is equal to 94% in 2008 and 97% in 2009, (b the financial performance of banks in 2008-2009 categorized not good, as measured by the quick ratio, quick ratio because the value is less than 100% is equal to 94% in 2008 and 97% in 2009, (cthe financial performance of banks in 2008-2009 categorized not good, measured from the cash ratio, because the value of the cash ratio less than 100% which is 28% in 2008 and 32% in 2009.(2 solvency ratio: (athe financial performance of banks in 2008-2009 categorized solvable measured by debt to net worth, because the value of debt to net worth of mo re than 25% in the amount of 942% in 2008 and 840% in 2009, (b the financial performance of banks in 2008-2009 categorized solvable, measured by total assets to net worth, because the value of total assets to net worth of more than 25% is equal to 1082% i n 2008 and 970% in 2009, (c the financial performance of banks in 2008-2009 categorized insolvable measured from fixed assets to net worth, as value of fixed assets to net worth less than 25% at 15% in 2008 and 12% in 2009.(3 The ratio of earnings: (a the banking company for the year 2008-2009 is still a very small benefit only Rp 0.0185,00 in 2008 and Rp 0.0223,00 in 2009, (b the banking company for the year 2008-2009 is still a very small benefit from its own capital only Rp 0.15,00 in 2008 and Rp 0.17,00 in 2009

Identification of triosephosphate isomerase as a novel allergen in Octopus fangsiao.

Science.gov (United States)

Yang, Yang; Chen, Zhong-Wei; Hurlburt, Barry K; Li, Gui-Ling; Zhang, Yong-Xia; Fei, Dan-Xia; Shen, Hai-Wang; Cao, Min-Jie; Liu, Guang-Ming

2017-05-01

Octopus is an important mollusk in human dietary for its nutritional value, however it also causes allergic reactions in humans. Major allergens from octopus have been identified, while the knowledge of novel allergens remains poor. In the present study, a novel allergen with molecular weight of 28kDa protein was purified from octopus (Octopus fangsiao) and identified as triosephosphate isomerase (TIM) by mass spectrometry. TIM aggregated beyond 45°C, and its IgE-binding activity was affected under extreme pH conditions due to the altered secondary structure. In simulated gastric fluid digestion, TIM can be degraded into small fragments, while retaining over 80% of the IgE-binding activity. The full-length cDNA of O. fangsiao TIM (1140bp) was cloned, which encodes 247 amino acid residues, and the entire recombinant TIM was successfully expressed in Escherichia coli BL21, which showed similar immunoreactivity to the native TIM. Different intensity of cross-reactivity among TIM from related species revealed the complexity of its epitopes. Eight linear epitopes of TIM were predicted following bioinformatic analysis. Furthermore, a conformational epitope (A 71 G 74 S 69 D 75 T 73 F 72 V 67 ) was confirmed by the phage display technology. The results revealed the physicochemical and immunological characteristics of TIM, which is significant in the development of hyposensitivity food and allergy diagnosis. Copyright © 2017 Elsevier Ltd. All rights reserved.

Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex.

Science.gov (United States)

Witosch, Justine; Wolf, Eva; Mizuno, Naoko

2014-11-10

The Timeless-Tipin (Tim-Tipin) complex, also referred to as the fork protection complex, is involved in coordination of DNA replication. Tim-Tipin is suggested to be recruited to replication forks via Replication Protein A (RPA) but details of the interaction are unknown. Here, using cryo-EM and biochemical methods, we characterized complex formation of Tim-Tipin, RPA and single-stranded DNA (ssDNA). Tim-Tipin and RPA form a 258 kDa complex with a 1:1:1 stoichiometry. The cryo-EM 3D reconstruction revealed a globular architecture of the Tim-Tipin-RPA complex with a ring-like and a U-shaped domain covered by a RPA lid. Interestingly, RPA in the complex adopts a horse shoe-like shape resembling its conformation in the presence of long ssDNA (>30 nucleotides). Furthermore, the recruitment of the Tim-Tipin-RPA complex to ssDNA is modulated by the RPA conformation and requires RPA to be in the more compact 30 nt ssDNA binding mode. The dynamic formation and disruption of the Tim-Tipin-RPA-ssDNA complex implicates the RPA-based recruitment of Tim-Tipin to the replication fork. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Timeless links replication termination to mitotic kinase activation.

Directory of Open Access Journals (Sweden)

Jayaraju Dheekollu

2011-05-01

Full Text Available The mechanisms that coordinate the termination of DNA replication with progression through mitosis are not completely understood. The human Timeless protein (Tim associates with S phase replication checkpoint proteins Claspin and Tipin, and plays an important role in maintaining replication fork stability at physical barriers, like centromeres, telomeres and ribosomal DNA repeats, as well as at termination sites. We show here that human Tim can be isolated in a complex with mitotic entry kinases CDK1, Auroras A and B, and Polo-like kinase (Plk1. Plk1 bound Tim directly and colocalized with Tim at a subset of mitotic structures in M phase. Tim depletion caused multiple mitotic defects, including the loss of sister-chromatid cohesion, loss of mitotic spindle architecture, and a failure to exit mitosis. Tim depletion caused a delay in mitotic kinase activity in vivo and in vitro, as well as a reduction in global histone H3 S10 phosphorylation during G2/M phase. Tim was also required for the recruitment of Plk1 to centromeric DNA and formation of catenated DNA structures at human centromere alpha satellite repeats. Taken together, these findings suggest that Tim coordinates mitotic kinase activation with termination of DNA replication.

Identification of a Degradation Signal Sequence within Substrates of the Mitochondrial i-AAA Protease.

Science.gov (United States)

Rampello, Anthony J; Glynn, Steven E

2017-03-24

The i-AAA protease is a component of the mitochondrial quality control machinery that regulates respiration, mitochondrial dynamics, and protein import. The protease is required to select specific substrates for degradation from among the diverse complement of proteins present in mitochondria, yet the rules that govern this selection are unclear. Here, we reconstruct the yeast i-AAA protease, Yme1p, to examine the in vitro degradation of two intermembrane space chaperone subunits, Tim9 and Tim10. Yme1p degrades Tim10 more rapidly than Tim9 despite high sequence and structural similarity, and loss of Tim10 is accelerated by the disruption of conserved disulfide bonds within the substrate. An unstructured N-terminal region of Tim10 is necessary and sufficient to target the substrate to the protease through recognition of a short phenylalanine-rich motif, and the presence of similar motifs in other small Tim proteins predicts robust degradation by the protease. Together, these results identify the first specific degron sequence within a native i-AAA protease substrate. Copyright © 2017 Elsevier Ltd. All rights reserved.

The plant i-AAA protease controls the turnover of an essential mitochondrial protein import component.

Science.gov (United States)

Opalińska, Magdalena; Parys, Katarzyna; Murcha, Monika W; Jańska, Hanna

2018-01-29

Mitochondria are multifunctional organelles that play a central role in energy metabolism. Owing to the life-essential functions of these organelles, mitochondrial content, quality and dynamics are tightly controlled. Across the species, highly conserved ATP-dependent proteases prevent malfunction of mitochondria through versatile activities. This study focuses on a molecular function of the plant mitochondrial inner membrane-embedded AAA protease (denoted i -AAA) FTSH4, providing its first bona fide substrate. Here, we report that the abundance of the Tim17-2 protein, an essential component of the TIM17:23 translocase (Tim17-2 together with Tim50 and Tim23), is directly controlled by the proteolytic activity of FTSH4. Plants that are lacking functional FTSH4 protease are characterized by significantly enhanced capacity of preprotein import through the TIM17:23-dependent pathway. Taken together, with the observation that FTSH4 prevents accumulation of Tim17-2, our data point towards the role of this i -AAA protease in the regulation of mitochondrial biogenesis in plants. © 2018. Published by The Company of Biologists Ltd.

Filler-depletion layer adjacent to interface impacts performance of thermal interface material

Directory of Open Access Journals (Sweden)

Susumu Yada

2016-01-01

Full Text Available When installing thermal interface material (TIM between heat source and sink to reduce contact thermal resistance, the interfacial thermal resistance (ITR between the TIM and heat source/sink may become important, especially when the TIM thickness becomes smaller in the next-generation device integration. To this end, we have investigated ITR between TIM and aluminum surface by using the time-domain thermoreflectance method. The measurements reveal large ITR attributed to the depletion of filler particles in TIM adjacent to the aluminum surface. The thickness of the depletion layer is estimated to be about 100 nm. As a consequence, the fraction of ITR to the total contact thermal resistance becomes about 20% when the TIM thickness is about 50 μm (current thickness, and it exceeds 50% when the thickness is smaller than 10 μm (next-generation thickness.

Kandungan Prinsip Konservatisme dalam Standar Akuntansi Keuangan Berbasis IFRS (International Financial Reporting Standard)

OpenAIRE

Ahmad Juanda

2012-01-01

Kandungan Prinsip Konservatisme DalamStandar Akuntansi Keuangan Berbasis IFRS(International Financial Reporting Standard)Ahmad JuandaStaf Pengajar Jurusan Akutansi, Fakultas Ekonomi dan BisnisUniversitas Muhammadiyah This study aims to reveal the content of the principle of conservatism contained in financial accounting standards (GAAP) results of the convergence of International Financial Reporting Standards (IFRS). The use of the principle of conservatism still...

Pengaruh Terpaan Komunikasi Pemasaran Menu Breakfast Mcdonald"s Keputusan Pembelian

OpenAIRE

Tasuki, Martia Mutiara; Pradekso, Tandiyo; Ulfa, Nurist Surayya

2013-01-01

PENGARUH TERPAAN KOMUNIKASI PEMASARAN MENU BREAKFAST MCDONALD'S DAN CITRA PRODUK TERHADAP KEPUTUSAN PEMBELIANSkripsiDisusun untuk memenuhi persyaratan menyelesaikanPendidikan Strata IJurusan Ilmu Komunikasi Fakultas Ilmu Sosial dan Ilmu PolitikUniversitas DiponegoroPenyusunNama : Martia Mutiara TasukiNIM : D2C 005 183JURUSAN ILMU KOMUNIKASIFAKULTAS ILMU SOSIAL DAN ILMU POLITIKUNIVERSITAS DIPONEGOROSEMARANG2013PENGARUH TERPAAN KOMUNIKASI PEMASARAN MENU BREAKFAST MCDONALD'S DAN CITRA PRODUK TER...

Perbandingan Gratification Sought Dan Gratification Obtained Pendengar Terhadap Program Stasiun Radio (Studi Komparatif tentang Motif dan Kepuasan Pendengar terhadap Program Stasiun Radio Kiss FM dan Prambors Medan di Kalangan Mahasiswa FISIP USU

OpenAIRE

Hutapea, Darma Lestari

2011-01-01

Penelitian ini bertujuan untuk membandingkan kepuasan ynag dicari (gratification sought) dan kepuasan yang diperoleh (gratification obtained) pendengar radio Kiss FM dan Prambors FM Medan dengan menggunakan perspektif Uses and Gratification. Model ini menekankan bahwa khalayak adalah pihak yang aktif terhadap penggunaan media. Khalayak bebas mengkonsumsi media yang disukainya. Sampel dalam penelitian ini adalah mahasiswa Fakultas Ilmu Sosial dan Ilmu Politik. Jumlah sampel y...

Respon Lima Varietas Jagung (Zea Mays L.) Pada Aplikasi Pyraclostrobin

OpenAIRE

Amin, Adi Wiyono Basori; Kuswanto, Kuswanto; Soegianto, Andy

2013-01-01

Aktivitas nitrat reduktase dapat ditingkatkan oleh pyraclostrobin. Penyerapan nitrogen pada tanaman dipengaruhi oleh aktivitas nitrat reduktase. Tujuan dari penelitian ini ialah untuk mempelajari respon lima varietas jagung pada aplikasi pyraclostrobin. Penelitian dilaksanakan di kebun percobaan Fakultas Pertanian Universitas Brawijaya yang berlokasi di Desa Jatikerto, Kecamatan Kromengan, Kabupaten Malang. Penelitian dilaksanakan pada bulan Juni 2011 sampai Oktober 2011. Bahan tanam yang di...

Pengalaman Komunikasi Pelanggan Zalora.co.id (Studi Fenomenologi Pelanggan Zalora.co.id)

OpenAIRE

Aji, Widya Andhika; Pradekso, Tandiyo; Ulfa, Nurist Surayya

2013-01-01

1PENGALAMAN KOMUNIKASI PELANGGAN ZALORA.CO.ID(Studi Fenomenologi Pelanggan Zalora.co.id)Oleh:Widya Andhika AjiFakultas Ilmu Sosial dan Ilmu PolitikUniversitas Diponegoro SemarangABSTRAKPenelitian ini bertujuan untuk menganalisis pengalaman komunikasi danpemahaman penerimaan konsumen terkait pesan komunikasi pemasaran dalamberbelanja di Zalora.co.id. Dengan menggunakan sampel pada lima informandan metode wawancara, dapat ditarik kesimpulan: Pelanggan Zalora.co.idmemiliki pengalaman komunikasi ...

Respon Tiga Varietas Sawi (Brassica Rapa L.) Terhadap Cekaman Air

OpenAIRE

Moctava, Mohammad Aries; Koesriharti, Koesriharti; Maghfoer, Mochammad Dawam

2013-01-01

Kebutuhan air tanaman berbeda-beda tergantung pada jenis tanamannya. Ketersediaan air bagi tanaman yang tidak mencukupi akan mempengaruhi morfologi dan fisiologis sehingga pertumbuhan dan hasil tanaman. Tujuan dari penelitian mendapatkan varietas sawi (Brassica rapa L.) yang tahan terhadap cekaman air. Penelitian dilaksanakan pada bulan Oktober sampai dengan Desember 2012. Tempat penelitian Kebun Percobaan Fakultas Pertanian Brawijaya, Desa Jatikerto, Kabupaten Malang.Penelitian menggunakan ...

Application of membrane-selective electrodes for the determination of Tiemonium methylsulphate

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Lobna A. Hussein

2017-06-01

Full Text Available Three ion selective electrodes were developed for the quantification of Tiemonium methylsulphate (TIM. Two of these sensors involve the construction of water insoluble ion-association complexes; namely sensor1 TIM-phosphotungstate (TIM-PT and sensor 2 TIM-Reinecke (TIM-R. Molecular recognition elements have extensive applications in electrochemical sensors with a significant potential for future development thus a third electrode utilizing molecularly imprinted polymer was constructed; sensor 3 TIM-MIP. The proposed sensors showed fast, stable Nernstian responses of 56.4, 56.1and 57.5 mV/decade for sensors 1, 2 and 3, respectively, across a relatively wide TIM concentration range (1 × 10−4 to 1 × 10−2 mol L−1 for sensors 1 and 2 and 1 × 10–5 to 1 × 10–2 mol L−1 for sensor 3 in the pH range of 2–7. Sensor 1 and sensor 2 can be used for five weeks while sensor 3 for 65 days without a significant change in sensitivity. The suggested method was used to determine TIM in dosage forms. No measurable difference was obtained when the result statistically compared with respect to accuracy and precision with reported HPLC method.

Identifikasi Rhizoctonia Mikoriza Pada Anggrekan Dan Kelompok Anastomosisnya

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Haryuni -

2013-03-01

Full Text Available Penelitian ini dilakukan di Laboratorium Klinik Fakultas Pertanian Universitas Gadjah Mada Yogyakarta dan Pusat Penelitian di Laboratorium Biologi Fakultas Pertanian Universitas Gifu di Jepang.Tujuan penelitian ini untuk mengidentifikasi dan melakukan anastomosis isolat jamur Rhizoctonia mikoriza (TMG-2, SR-9 dan SR-8. Tester yang digunakan yaitu AG-F SIR.9, AG-F Fko.2.28, and AG-F PS.17. Hasil penelitian menunjukkan bahwa Identifikasi SR-8 memiliki ciri pada Rhizoctonia binukleat (BNR dan dikelompokkan kedalam AG-F (teleomorf: Ceratobasidium sp.The experiment was carried out at the Laboratory of Clinical Plant Pathology, Faculty of Agriculture, Gadjah Mada University in Yogyakarta and the Research Center at the Laboratory of Agriculture Biology, Gifu University in Japan. The objectives of the experiment were to identify and to test anastomosis group of orchid mycorrhizal Rhizoctonia TMG-2, SR-9, and SR-8 isolates. The tester of Rhizoctonia to be used were AG-F SIR.9, AG-F Fko.2.28, and AG-F PS.17. Results of the study showed that SR-8 belongs to binucleate Rhizoctonia (BNR and grouped into AG F (teleomorph: Ceratobasidium sp.

Fixing the Sorting Algorithm for Android, Java and Python

NARCIS (Netherlands)

C.P.T. de Gouw (Stijn); F.S. de Boer (Frank)

2015-01-01

htmlabstractTim Peters developed the Timsort hybrid sorting algorithm in 2002. TimSort was first developed for Python, a popular programming language, but later ported to Java (where it appears as java.util.Collections.sort and java.util.Arrays.sort). TimSort is today used as the default sorting

“How to Track Baby Feedings” Penerapan Model Dokumentasi Dengan Menggunakan Software Sebagai Upaya Meningkatkan Pertumbuhan Dan Perkembangan Pada Bayi

OpenAIRE

Dwi Susanti, Henny

2014-01-01

“How To Track Baby Feedings” Penerapan Model Dokumentasi Dengan Menggunakan Software Sebagai Upaya Meningkatkan Pertumbuhan dan Perkembangan Pada Bayi“How to Track Baby Feedings” Implementation Documentation Model by Using Software as an Effort to Improve Growth and Development in InfantsHenny Dwi SusantiFakultas Ilmu Kesehatan, Universitas Muhammadiyah MalangJl. Bendungan Sutami 188A Malang 65145E-mail : Pertumbuhan adalah bertambahnya ukuran tubuh, sedangkan perk...

INTERAKSI KEBIJAKAN RENEWABLE ENERGY DIRECTIVE DAN KEBIJAKAN INDONESIAN SUSTAINABLE PALM OIL TERHADAP EKSPOR KELAPA SAWIT INDONESIA KE UNI EROPA

OpenAIRE

-, INTAN TIARA KARTIKA

2016-01-01

2016 INTAN TIARA KARTIKA, E13112274, Interaksi Kebijakan Renewable Energy Directive dan Indonesian Sustainable Palm Oil Terhadap Ekspor Kelapa Sawit Indonesia ke Uni Eropa. Dibimbing oleh Prof. Dr. H. Mappa Nasrun, MA selaku pembimbing I dan H. Darwis MA, Ph.D selaku pembimbing II, departemen Ilmu Hubungan Internasional, Fakultas Ilmu Soisal dan Ilmu Politik, Universitas Hassanuddin. Penelitian ini bertujuan untuk mengetahui dan menjelaskan Interaksi Kebijakan Renewa...

Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo

Czech Academy of Sciences Publication Activity Database

Macháčková, Martina; Oborník, Miroslav; Kopecký, Jan

2006-01-01

Roč. 53, č. 2 (2006), s. 153-158 ISSN 0015-5683 R&D Projects: GA ČR GA524/05/0811 Grant - others:Studentská grantová agentura, Biologická fakulta Jihočeské univerzity(CZ) SGA2004/009 Institutional research plan: CEZ:AV0Z60220518 Keywords : Borrelia burgdorferi * Ixodes ricinus * saliva-activated transmission Subject RIV: EC - Immunology Impact factor: 1.511, year: 2006

KEBIJAKAN INVESTASI ASING BIDANG PERTAMBANGAN DI KABUPATEN POHUWATO PROVINSI GORONTALO KEBIJAKAN INVESTASI ASING BIDANG PERTAMBANGAN DI KABUPATEN POHUWATO PROVINSI GORONTALO KEBIJAKAN INVESTASI ASING BIDANG PERTAMBANGAN DI KABUPATEN POHUWATO PROVINSI GORONTALO KASUS PT. PANI DHARMA MAS KASUS PT. PANI DHARMA MAS KASUS PT. PANI DHARMA MAS

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PUYO, AJENG MAWADDAH PUYO AJENG MAWADDAH PUYO AJENG MAWADDAH

2016-01-01

2016 AJENG MAWADDAH PUYO, E 131 12 003, "Kebijakan Investasi Asing Dalam Bidang Pertambangan di Kabupaten Pohuwato Provinsi Gorontalo Kasus PT. Pani Dharma MAS", dibawah bimbingan Dr. H. Adi Suryadi B., MA selaku pembimbing I dan Pusparida Syahdan. S.sos., MSI, Departemen Ilmu Hubungan internasional, Fakultas Ilmu Sosial dan Ilmu Politik, Universitas Hasanuddin. Penelitian ini bertujuan untuk mengetahui peran stakeholders dalam perumusan kebijakan investasi asing da...

Pengaruh Brand Image terhadap Kesetiaan Pengguna Smartphone Iphone

OpenAIRE

Saputri, Marheni Eka; Pranata, Tutut Ratna

2014-01-01

Persaingan industri elektronik khususnya smartphone saat ini mengalami perkembangan cukup pesat. Perusahaan menggunakan berbagai strategi untuk merebut dan mempertahankan konsumen. Salah satunya dengan membuat brand image yang kuat sehingga menjadi top of mind di hati pelanggan. Penelitian ini bertujuan untuk mengetahui pengaruh brand image terhadap loyalitas pengguna smartphone iPhone di Universtas Telkom Fakultas Bisnis dan Adminitrasi. Jenis penelitian yang digunakan adalah penelitian desk...

Urban Studies in Chech Scholarly Journals / Lud'a Klusakova

Index Scriptorium Estoniae

Klusakova, Lud'a

2009-01-01

Rets. ajak.: Slavomira Ferenèuhova. Michaela ₂ulerova, Barbora Vackova (eds.). Mesto [the city]. Socialni studia [Social Studies]. 2006:2. Fakulta Socialnich Studii [Falti of Socail Studies], Masarykova Universita [Masaryk University]. Brno, 2006 ; Urban People -Lidé mesta. Review of Antropology, Ethnology and Ethnology of Communication, 2007 : 1 - 20, Faculty of Humanities, Charles Univerity in Prague. Prague, 2007. Kahe väljaande võrdlus.

Penjajakan Kadar Logam Berat Pb Pada Tanaman Kangkung Darat (Ipomea reptans Poir) Asal Kecamatan Medan Deli Dan Kangkung Air (Ipomea aquatica Forsk) Asal Kecamatan Sunggal Kota Medan.

OpenAIRE

Rumajar, Antonius Theodorus B

2011-01-01

Penelitian ini dilakukan di lahan pertanian kangkung darat (Ipomea reptans Poir) asal kecamatan Medan Deli dan kangkung air (Ipomea aquatica Forsk) asal kecamatan Sunggal kota Medan dan Laboratorium Riset dan Teknologi Fakultas Pertanian, Universitas Sumatera Utara Medan yang dilakukan pada bulan Juni 2010 sampai Oktober 2010. Penelitian ini menggunakan alat AAS (Atomic Absorption Spectroscopy) dengan dua (2) kali ulangan berdasarkan metode deskriptif analitik. Hasil penelitian menunjukkan ba...

Framing Persoalan Indonesia Melalui Film Dokumenter Model Direct Cinema (Studi Pada Film-film Dokumenter Terbaik, Program Eagle Award Competitions Di Metro TV)

OpenAIRE

Styo Wibowo, Novin Farid

2013-01-01

FRAMING PERSOALAN INDONESIA MELALUI FILM DOKUMENTER MODELDIRECT CINEMA(STUDI PADA FILM-FILM DOKUMENTER TERBAIK, PROGRAM EAGLEAWARD COMPETITIONS DI METRO TV)Frames Indonesia Issues Through Direct Cinema DocumentaryFilm On Television (Framing Analysis of the 3 Best Documentary Film, Eagle AwardCompetitions Program at Metro TV)Novin Farid Styo WibowoJurusan Ilmu Komunikasi, Fakultas Ilmu Sosial dan Ilmu PolitikUniversitas Muhammadiyah MalangEmail : TThe research disc...

Reviewer Volume 29, Tahun 2009

OpenAIRE

Volume 29, Tahun 2009, Reviewer

2012-01-01

Achmad Subagio, Fakultas Teknologi Pertanian (FTP), Universitas Jember, Jl. Kalimantan I, Kampus Tegal Boto, Jember 68121Agustin K., Wardani FTP, Universitas Brawijaya, Malang, Jl. Veteran, Malang 65145Bambang Purwantana, Jurusan Teknik Pertanian (TEP), FTP, Universitas Gadjah Mada (UGM), Jl. Flora, Bulaksumur,Yogyakarta 55281Chusnul Hidayat, Jurusan Teknologi Pangan dan Hasil Pertanian (TPHP), FTP, UGMDidik Purwadi, Jurusan Teknologi Industri Pertanian (TIP), FTP, UGMDjagal Wiseso Marseno, ...

Indtroduction To Research Methodologies In Language Studies

Directory of Open Access Journals (Sweden)

Muhartoyo Muhartoyo

2007-05-01

Full Text Available Penelitian bahasa merupakan bidang yang menarik bagi mahasiswa dan pengajar di Fakultas Sastra. Artikel ini mencoba menggambarkan berbagai metodologi riset dalam bidang bahasa dengan cara yang sederhana. Metodologi riset ini mencakup experimental research, quasi experimental research, etnografi, dan studi kasus. Artikel ini juga membahas konsep metode riset kuantitatif dan kualitatif. Masalah validitas dan keabsahan sebuah laporan riset dibahas secara singkat.

Hubungan Antara Intensitas Menonton Program Memasak Di Televisi Dan Kompetensi Chef Presenter Dalam Program Memasak Terhadap Minat Penonton Untuk Memasak

OpenAIRE

UTAMI, DITA PURMIA; Suprihatini, Taufik; Herieningsih, Sri Widowati

2013-01-01

Hubungan Intensitas Menonton Program Memasak di Televisi dan Kompetensi ChefPresenter dalam Program Memasak terhadap Minat Penonton untuk MemasakSkripsiDisusun untuk memenuhi persyaratan menyelesaikanPendidikan Strata 1Jurusan Ilmu Komunikasi Fakultas Ilmu Sosial dan Ilmu PolitikUniversitas DiponegoroPenyusunNama : DITA PURMIA UTAMINIM : D2C008083JURUSAN ILMU KOMUNIKASIFAKULTAS ILMU SOSIAL DAN ILMU POLITIKUNIVERSITAS DIPONEGORO2013ABSTRAKSIJUDUL : HUBUNGAN ANTARA INTENSITAS MENONTON PROGRAMME...

Efektivitas Implementasi Convention On The Elimination Of All Forms Of Discrimination Against Woman (CEDAW) Terhadap Penurunan diskriminasi perempuan di Pakistan

OpenAIRE

MURSALIN, FAHIRA ULFA

2017-01-01

2017 FAHIRA ULFA MURSALIN, E 131 13 514. Skripsi yang berjudul ???Efektivitas Implementasi Convention On The Elimination Of All Form Of Discrimination Against Woman (Cedaw) Terhadap Penurunan Diskriminasi Perempuan Di Pakistan???. Di bawah bimbingan bapak H. Darwis, MA, Ph.D selaku pembimbing I dan bapak Burhanuddin, S.IP. M.SI selaku pembimbing II, pada Jurusan Ilmu Hubungan Internasional, Fakultas Ilmu Sosial dan Ilmu Politik, ...

Tinjauan Kriminologi dan Psikologi Kriminil Terhadap Tindak Pidana Kekerasan Seksual Pedofilia (Studi Kasus di Pengadilan Negeri Medan)

OpenAIRE

Afriska Nababan

2008-01-01

Skripsi ini berjudul "Tinjauan Kriminologi dan Psikologi Kriminil Terhadap Tindak Pidana Kekerasan Seksual Pedofilia (Studi Kasus di Pengadilan Negeri Medan)". Merupakan tugas akhir Penulis untuk memenuhi syarat-syarat dan tugas-tugas dalam memperoleh gelar Sarjana Hukum di Fakultas Hukum Universitas Sumatera Utara. Masalah kekerasan seksual yang sebagian besar terjsdi pada anak-anak dibawah umur merupakan persoalan yang aktual hamper disemua negara didunia, termasuk Indonesia. Akhir-akhir in...

Efficacy and tolerability of fixed-combination brinzolamide/timolol in Latin American patients with open-angle glaucoma or ocular hypertension previously on brimonidine/timolol fixed combination.

Science.gov (United States)

Alezzandrini, Arturo; Hubatsch, Douglas; Alfaro, Rene

2014-09-01

Fixed-combination glaucoma medications are commonly used to achieve target intraocular pressure (IOP) reduction in patients uncontrolled with monotherapy; however, ocular discomfort associated with eye drops can decrease adherence. This study assessed the efficacy and tolerability of twice-daily fixed-combination brinzolamide 1%/timolol 0.5% (BRINZ/TIM-FC) in Latin American patients transitioned from fixed-combination brimonidine 0.2%/timolol 0.5% (BRIM/TIM-FC) because of insufficient IOP control or treatment intolerance. This 8-week, open-label, prospective study was conducted at six sites in Argentina, Chile, and Mexico. Enrolled patients were aged ≥18 years with open-angle glaucoma (including primary, exfoliative, or pigment-dispersion glaucoma) or ocular hypertension with IOP of 19-35 mmHg in ≥1 eye at baseline (on BRIM/TIM-FC). Patients self-administered BRINZ/TIM-FC to both eyes at 8 a.m. and 8 p.m. daily for 8 weeks. The primary and secondary efficacy endpoints were mean IOP change from baseline at week 8 and percentage of patients achieving target IOP (≤18 mmHg) at week 8, respectively. Exploratory endpoints included patient and investigator preference for treatment at week 8. Adverse events (AEs) were assessed as the safety endpoint. Fifty patients (mean ± SD age, 66.7 ± 11.5 years) received BRINZ/TIM-FC, and 49 were included in the intent-to-treat population. Mean ± SD IOP was significantly reduced from baseline after 8 weeks of treatment with BRINZ/TIM-FC (-3.6 ± 3.0 mmHg; P Wilcoxon signed-rank test; 17.1% reduction). Overall, 55.3% of patients achieved IOP ≤18 mmHg at week 8. Significantly more patients (89.4%) and investigators (95.7%) preferred BRINZ/TIM-FC to BRIM/TIM-FC (both P test). Of the 13 AEs observed, 8 were related to BRINZ/TIM-FC; the most common treatment-related AEs were eye irritation (n = 4) and abnormal sensation in the eye (n = 2). BRINZ/TIM-FC provides an effective and well-tolerated treatment

Effects of vocal training in a musicophile with congenital amusia.

Science.gov (United States)

Wilbiks, Jonathan M P; Vuvan, Dominique T; Girard, Pier-Yves; Peretz, Isabelle; Russo, Frank A

2016-12-01

Congenital amusia is a condition in which an individual suffers from a deficit of musical pitch perception and production. Individuals suffering from congenital amusia generally tend to abstain from musical activities. Here, we present the unique case of Tim Falconer, a self-described musicophile who also suffers from congenital amusia. We describe and assess Tim's attempts to train himself out of amusia through a self-imposed 18-month program of formal vocal training and practice. We tested Tim with respect to music perception and vocal production across seven sessions including pre- and post-training assessments. We also obtained diffusion-weighted images of his brain to assess connectivity between auditory and motor planning areas via the arcuate fasciculus (AF). Tim's behavioral and brain data were compared to that of normal and amusic controls. While Tim showed temporary gains in his singing ability, he did not reach normal levels, and these gains faded when he was not engaged in regular lessons and practice. Tim did show some sustained gains with respect to the perception of musical rhythm and meter. We propose that Tim's lack of improvement in pitch perception and production tasks is due to long-standing and likely irreversible reduction in connectivity along the AF fiber tract.

The Glycolytic Enzyme Triosephosphate Isomerase of Trichomonas vaginalis Is a Surface-Associated Protein Induced by Glucose That Functions as a Laminin- and Fibronectin-Binding Protein.

Science.gov (United States)

Miranda-Ozuna, Jesús F T; Hernández-García, Mar S; Brieba, Luis G; Benítez-Cardoza, Claudia G; Ortega-López, Jaime; González-Robles, Arturo; Arroyo, Rossana

2016-10-01

Triosephosphate isomerase of Trichomonas vaginalis (TvTIM) is a 27-kDa cytoplasmic protein encoded by two genes, tvtim1 and tvtim2, that participates in glucose metabolism. TvTIM is also localized to the parasite surface. Thus, the goal of this study was to identify the novel functions of the surface-associated TvTIM in T. vaginalis and to assess the effect of glucose as an environmental factor that regulates its expression and localization. Reverse transcription-PCR (RT-PCR) showed that the tvtim genes were differentially expressed in response to glucose concentration. tvtim1 was overexpressed under glucose-restricted (GR) conditions, whereas tvtim2 was overexpressed under glucose-rich, or high-glucose (HG), conditions. Western blot and indirect immunofluorescence assays also showed that glucose positively affected the amount and surface localization of TvTIM in T. vaginalis Affinity ligand assays demonstrated that the recombinant TvTIM1 and TvTIM2 proteins bound to laminin (Lm) and fibronectin (Fn) but not to plasminogen. Moreover, higher levels of adherence to Lm and Fn were detected in parasites grown under HG conditions than in those grown under GR conditions. Furthermore, pretreatment of trichomonads with an anti-TvTIMr polyclonal antibody or pretreatment of Lm- or Fn-coated wells with both recombinant proteins (TvTIM1r and TvTIM2r) specifically reduced the binding of live parasites to Lm and Fn in a concentration-dependent manner. Moreover, T. vaginalis was exposed to different glucose concentrations during vaginal infection of women with trichomoniasis. Our data indicate that TvTIM is a surface-associated protein under HG conditions that mediates specific binding to Lm and Fn as a novel virulence factor of T. vaginalis. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Perbedaan Sikap Pemilih Pemula Antara Peserta Dan Bukan Peserta “Roadshow Pendidikan Pemilu”

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Almira Ditrya Kartikatantri

2015-07-01

Universitas Indonesia sebagai peserta dan mahasiswa D3 Studi Ilmu Sosial dan Politik Universitas Indonesia yang bukan sebagai peserta “Roadshow Pendidikan Pemilu” dalam Pemilihan Umum Legislatif 2014. Dalam penelitian ini digunakan metode kuantitatif, berdasarkan Teori Persuasi (Instrumental Theory of Persuassions yang dikemukakan oleh Hovland, Janis, dan Kelly. Pengujian yang digunakan adalah uji beda Mann-Whitney dengan teknik analisis deskriptif dan interferensial. Hasil penelitian menunjukkan bahwa terdapat perbedaan sikap yang signifikan antara sampel yang mengikuti dengan yang tidak mengikuti kampanye “Roadshow Pendidikan Pemilu” yang diadakan oleh tim AyoVote. Artinya kegiatan yang dilakukan berhasil mengubah sikap peserta kegiatan menjadi lebih positif sesuai dengan harapan pelaksana kegiatan. Berdasarkan hasil penelitian ini, penulis menyarankan agar tim AyoVote membenahi isi pesan supaya lebih terstruktur dan lebih menarik untuk disampaikan kepada peserta, sehingga pengaruh yang diberikan akan dapat lebih signifikan dan menambah frekuensi pelaksanaan kegiatan, sehingga makin banyak orang yang tahu berbagai ilmu dasar politik dan sadar akan kewajibannya sebagai masyarakat Indonesia yang memilki hak pilih untuk menentukan masa depan negerinya.

Mengelola Proses Tim

OpenAIRE

Raharso, Sri

2012-01-01

Work teams has become relatively common in organizations because brilliant execution that can onlybe done with teamwork. A team as a group of individuals who work together under a unity of purpose,as a united front. But develop team is not easy, take some years. When team leaders focus primarily onhard business tools, such as schedule, budget, and scope, they can lose sight of a more subjective aspectof the project—the team member. Each person brings a unique set of experiences and knowledge ...

Representasi Persahabatan dalam Film 5 Cm

OpenAIRE

Handayani, Intan Murni; Lukmantoro, Triyono; Naryoso, Agus

2013-01-01

Representasi Persahabatan dalam Film 5 cmSkripsiDisusun untuk memenuhi persyaratan menyelesaikanPendidikan Strata-1Jurusan IlmumKomunikasi Fakultas Ilmu Sosial dan Ilmu PolitikUniversitas DiponegoroPenyusunNama: Intan Murni HandayaniNIM: D2C 009 034JURUSAN ILMU KOMUNIKASIFAKULTAS ILMU SOSIAL DAN ILMU POLITIKUNIVERSITAS DIPONEGOROSEMARANG2013ABSTRAKSIFilm merupakan salah satu media massa yang menjadi wadah bagi parapembuat film untuk menyampaikan pesan serta nilai-nilai yang dimiliki olehpara ...

Perancangan & Simlasi Security LAN Dengan Perangkat CISCO

OpenAIRE

Asma, Nur

2013-01-01

Perancangan ini dikembangkan dengan menggunakan perangkat lunak CISCO paket tracer. Biasanya dalam satu gedung fakultas mahasiswa berada dalam satu LAN sedangkan komputer dosen berada pada LAN lain. Hal ini sepertinya sudah sewajarna terjadi mengingat keadaan jaringan yang terhubung secara fisik. Jadi tujuan perancangan ini adalah membangun sistem keamanan LAN dengan sistem VLAN dan dijalankan dengan perangkat CISCO dari paket tracer. VLAN (Virtual Local Area Network) merupakan salah satu tek...

Perancangan dan Simulasi Security LAN dengan Perangkat Cisco

OpenAIRE

Asma, Nur

2015-01-01

Perancangan ini dikembangkan dengan menggunakan perangkat lunak CISCO paket tracer. Biasanya dalam satu gedung fakultas mahasiswa berada dalam satu LAN sedangkan komputer dosen berada pada LAN lain. Hal ini sepertinya sudah sewajarna terjadi mengingat keadaan jaringan yang terhubung secara fisik. Jadi tujuan perancangan ini adalah membangun sistem keamanan LAN dengan sistem VLAN dan dijalankan dengan perangkat CISCO dari paket tracer. VLAN (Virtual Local Area Network) merupakan salah satu tek...

Pemanfaatan Limbah Batu Marmer Sebagai Pengganti Agregat Kasar Pada Campuran Aspal Beton Terhadap Karakteristik Marshall

OpenAIRE

Syaiful Amal, Andi; Saleh, Chairil

2015-01-01

PEMANFAATAN LIMBAH BATU MARMER SEBAGAI PENGGANTI AGREGAT KASAR PADA CAMPURAN ASPAL BETON TERHADAP KARAKTERISTIK MARSHALLThe Implementation Of Stone Marble Waste For Changer The Aggregate Rough To Mix Aplhalt Concrete Characteristics Of MarshalAndi Syaiful Amal1 & Chairil Saleh21,2Jurusan Teknik Sipil – Fakultas Teknik Univ. Muhammadiyah MalangAlamat Korespondensi : Jl. Raya Tlogomas No. 246 Malang 65144Email : The waste of marble stone is waste produced when manu...

Recovery of maize (Zea mays L.) inbreds and hybrids from chilling stress of various duration: plant development, photosynthesis and antioxidative enzymes

Czech Academy of Sciences Publication Activity Database

Holá, D.; Kočová, M.; Rothová, O.; Wilhelmová, Naděžda; Benešová, M.

2007-01-01

Roč. 164, - (2007), s. 868-877 ISSN 0176-1617 Grant - others:Univerzita Karlova v Praze / Přírodovědecká fakulta(CZ) GP522/02/D174 Institutional research plan: CEZ:AV0Z50380511 Source of funding: V - iné verejné zdroje Keywords : Antioxidant enzymes * chilling * intraspecific variability * photosynthesis * recovery * Zea mays Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.239, year: 2007

Hubungan Eksekutif Dan Legislatif Dalam Penetapan Perda APBD Tahun 2014 di Kabupaten Barru

OpenAIRE

SRI RAMADANI, RESKY

2014-01-01

2014 INTISARI RESKY SRI RAMADANI, Nomor pokok E121 10 105, Program Studi Ilmu Pemerintahan Jurusan Ilmu Politik Pemerintahan, Fakultas Ilmu Sosial dan Ilmu Politik Universitas Hasanuddin, menyusun skripsi dengan judul : ???HUBUNGAN EKSEKUTIF DAN LEGISLATIF DALAM PENETAPAN PERDA APBD TAHUN 2014 DI KABUPATEN BARRU??? di bawah bimbingan Dr. H. A. Samsu Alam, M.Si dan Dr. Nurlinah, M.Si Penelitian ini bertujuan untuk mengetahui bagaimana keterkaitan eksekutif dan legisl...

Promosi Manajemen Nyeri Nonfarmakologi Oleh Keluarga Pada Pasien Post Operasi Di Ruang BCH RSUPN Dr.Ciptomangun Kusumo Jakarta

OpenAIRE

Ilmiasih, Reni

2013-01-01

Promosi Manajemen Nyeri Nonfarmakologi oleh Keluarga pada Pasien Post Operasi di Ruang BCH RSUPN Dr.Ciptomangun Kusumo JakartaNonpharmacological Pain Management Promotion by family to the Post Surgery Patients in BCH Ward of RSUPN Dr.Ciptomangun Kusumo JakartaReni IlmiasihFakultas Ilmu Kesehatan Universitas Muhammadiyah MalangJl. Bendungan Sutami 188A Malang 65145E-mail : anajemen nyeri non farmakologi perlu dilakukan oleh perawat di ruang bedah meskipun sering d...

Superhero Characteristic Comparison Between 1938 Superman and 21st Century Iron Man as a Reflection of the American Era

OpenAIRE

PUTRA, ALDILLA YUNIRWAN

2014-01-01

Putra, Aldilla Yunirwan. 2014. Superhero Characteristic Comparison between 1938 Superman and 21ST Century Iron Man as A Reflection of the American Era. Program Studi Sastra Inggris, Jurusan Bahasa dan Sastra, Fakultas Ilmu Budaya, Universitas Brawijaya, Pembimbing: (I) M. Andhy Nurmansyah (II) Nurul Laili. Keywords: American Superhero, Popular Culture, Entertainment, American Society. Superheroes are wellknown throughout the world, they appear in various medias to amuse the people as...

Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein.

Science.gov (United States)

Banerjee, Rupa; Gladkova, Christina; Mapa, Koyeli; Witte, Gregor; Mokranjac, Dejana

2015-12-29

The majority of mitochondrial proteins are targeted to mitochondria by N-terminal presequences and use the TIM23 complex for their translocation across the mitochondrial inner membrane. During import, translocation through the channel in the inner membrane is coupled to the ATP-dependent action of an Hsp70-based import motor at the matrix face. How these two processes are coordinated remained unclear. We show here that the two domain structure of Tim44 plays a central role in this process. The N-terminal domain of Tim44 interacts with the components of the import motor, whereas its C-terminal domain interacts with the translocation channel and is in contact with translocating proteins. Our data suggest that the translocation channel and the import motor of the TIM23 complex communicate through rearrangements of the two domains of Tim44 that are stimulated by translocating proteins.

Jurusan Akuntansi Fakultas Ekonomi Universitas Udayana

Directory of Open Access Journals (Sweden)

I PUTU ADNYANA USADHA

2009-07-01

Full Text Available The purpose of this research is to gain empirical evidence whetheracquiring companies conduct earnings management before the execution ofmerger and acquisition. It also aims to investigate performance changes ofacquiring companies before and after merger and acquisition.Earnings management conducted by the companies is proxied bydiscretionary accrual (DA. Analysis is done using independent sample ttestand paired sample test. The result shows that there is an indication ofearnings management done by taking over companies before merger andacquisition by utilizing income increasing accruals. Furthermore, thefinancial performance of the companies is lower after merger andacquisition took place.

Pembangunan Aplikasi Perhitungan Honor dan Pengukuran Kinerja Asisten Praktikum Berbasis SaaS

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Fitri Susanti

2015-11-01

Full Text Available Bagi suatu perguruan tinggi, kegiatan praktikum sangat penting untuk mendukung pembelajaran di kelas. Beberapa masalah yang muncul dalam pengelolaan kegiatan praktikum seperti keterlambatan pengumpulan berita acara praktikum (BAP sehingga memperlambat perhitungan, pembayaran dan pelaporan honor asprak. Dibutuhkan waktu sekitar dua minggu untuk rekapitulasi dan validasi ratusan lembar BAP yang telah terkumpul setiap bulannya. Dibutuhkan pengolahan data lebih lanjut untuk menilai kinerja asprak berdasarkan data BAP. Untuk mengatasi permasalahan di atas maka dibangun aplikasi perhitungan honor dan kinerja asprak. Aplikasi ini digunakan untuk mengelola data BAP, perhitungan dan pelaporan honor, perhitungan nilai transkrip aktivitas kemahasiswaan (TAK dan pencetakan sertifikat asprak. Keterbatasan SDM atau biaya menyebabkan tidak semua perguruan tinggi dapat langsung membuat aplikasi yang dibutuhkan. Oleh karena itu aplikasi ini dibangun berbasis Software as A Service (SaaS. Aplikasi ini dikembangkan dengan metode analisis perancangan terstruktur dengan model waterfall. Pengumpulan data kebutuhan aplikasi dilakukan dengan survey ke fakultas-fakultas di Universitas Telkom. Hasilnya dianalisis dan dikembangkan menjadi rancangan aplikasi. Aplikasi diimplementasikan pada pemrograman PHP. Pengujian dilakukan dengan metode black box testing. Hasilnya berupa aplikasi SaaS untuk perhitungan honor dan pengukuran kinerja asisten praktikum. Perguruan tinggi pengguna aplikasi SaaS ini dapat melakukan kostumisasi terhadap fitur yang ada sesuai dengan kebutuhan.

Structural insights from a novel invertebrate triosephosphate isomerase from Litopenaeus vannamei

Science.gov (United States)

Lopez-Zavala, Alonso A.; Carrasco-Miranda, Jesus S.; Ramirez-Aguirre, Claudia D.; López-Hidalgo, Marisol; Benitez-Cardoza, Claudia G.; Ochoa-Leyva, Adrian; Cardona-Felix, Cesar S.; Diaz-Quezada, Corina; Rudiño-Piñera, Enrique; Sotelo-Mundo, Rogerio R.; Brieba, Luis G.

2016-01-01

Triosephosphate isomerase (TIM; EC 5.3.1.1) is a key enzyme involved in glycolysis and gluconeogenesis. Glycolysis is one of the most regulated metabolic pathways, however little is known about the structural mechanisms for its regulation in non-model organisms, like crustaceans. To understand the structure and function of this enzyme in invertebrates, we obtained the crystal structure of triosephosphate isomerase from the marine Pacific whiteleg shrimp (Litopenaeus vannamei, LvTIM) in complex with its inhibitor 2-phosphogyceric acid (2-PG) at 1.7 Å resolution. LvTIM assembles as a homodimer with residues 166-176 covering the active site and residue Glu166 interacting with the inhibitor. We found that LvTIM is the least stable TIM characterized to date, with the lowest range of melting temperatures, and with the lowest activation enthalpy associated with the thermal unfolding process reported. In TIMs dimer stabilization is maintained by an interaction of loop 3 by a set of hydrophobic contacts between subunits. Within these contacts, the side chain of a hydrophobic residue of one subunit fits into a cavity created by a set of hydrophobic residues in the neighboring subunit, via a "ball and socket" interaction. LvTIM presents a Cys47 at the "ball" inter-subunit contact indicating that the character of this residue is responsible for the decrease in dimer stability. Mutational studies show that this residue plays a role in dimer stability but is not a solely determinant for dimer formation. PMID:27614148

Dense Vertically Aligned Copper Nanowire Composites as High Performance Thermal Interface Materials.

Science.gov (United States)

Barako, Michael T; Isaacson, Scott G; Lian, Feifei; Pop, Eric; Dauskardt, Reinhold H; Goodson, Kenneth E; Tice, Jesse

2017-12-06

Thermal interface materials (TIMs) are essential for managing heat in modern electronics, and nanocomposite TIMs can offer critical improvements. Here, we demonstrate thermally conductive, mechanically compliant TIMs based on dense, vertically aligned copper nanowires (CuNWs) embedded into polymer matrices. We evaluate the thermal and mechanical characteristics of 20-25% dense CuNW arrays with and without polydimethylsiloxane infiltration. The thermal resistance achieved is below 5 mm 2 K W -1 , over an order of magnitude lower than commercial heat sink compounds. Nanoindentation reveals that the nonlinear deformation mechanics of this TIM are influenced by both the CuNW morphology and the polymer matrix. We also implement a flip-chip bonding protocol to directly attach CuNW composites to copper surfaces, as required in many thermal architectures. Thus, we demonstrate a rational design strategy for nanocomposite TIMs that simultaneously retain the high thermal conductivity of aligned CuNWs and the mechanical compliance of a polymer.

PENCEGAHAN KECURANGAN (FRAUD DALAM PELAKSANAAN PROGRAM JAMINAN KESEHATAN PADA SISTEM JAMINAN SOSIAL KESEHATAN (SJSN (Studi di Rumah Sakit Umum Daerah Menggala Tulang Bawang

Directory of Open Access Journals (Sweden)

Tatik Sri Hartati

2017-05-01

Abstrak Sistem pencegahan penipuan JKN di rumah sakit Menggala sebagai Sarana Rujukan Kesehatan Lanjutan (FKRTL. Dengan menciptakan Penipuan Pencegahan Tim, berdasarkan Keputusan Direktur Rumah Sakit Menggala dengan SK No. 800/876/III.12/TB/IX/2015 tentang Tim Pencegahan Penipuan. Salah satu kegiatan tugas tim adalah melakukan pencegahan, deteksi dan penuntutan penipuan JKN. Sistem ini telah dibangun dalam upaya untuk Mencegah rumah sakit Menggala JKN sesuai dengan Surat Keputusan oleh menteri kesehatan Nomor 36 Tahun 2015. Kemudian, keluhan System atau laporan kecurangan di rumah sakit Format Menggala JKN dilakukan dengan menulis ditujukan kepada Penipuan yang Tim pencegahan. Keluhan atau laporan dugaan penipuan JKN, harus Terdiri dari setidaknya meliputi: identitas pelapor, nama dan alamat lembaga yang diduga aksi penipuan JKN lakukan, dan alasan untuk keluhan. Dalam hal terjadi jika ada ketidaksepakatan pada penentuan apakah ada JKN penipuan atau tidak, Dinas Kesehatan Propinsi atau Dinas Kesehatan Kabupaten / Kota dapat meneruskan keluhan untuk pencegahan penipuan tim JKN didirikan oleh Menteri.   Kata Kunci: Kecurangan, Pencegahan, Keluhan.

Carbon nanotube thermal interfaces and related applications

OpenAIRE

Hodson, Stephen L

2016-01-01

The development of thermal interface materials (TIMs) is necessitated by the temperature drop across interfacing materials arising from macro and microscopic irregularities of their surfaces that constricts heat through small contact regions as well as mismatches in their thermal properties. Similar to other types of TIMs, CNT TIMs alleviate the thermal resistance across the interface by thermally bridging two materials together with cylindrical, high-aspect ratio, and nominally vertical cond...

Nilai Pendidikan Dalam Komik One Piece Jilid 1-23 Karya Eiichiro Oda (Sebuah Tinjauan Sosiologi Sastra)

OpenAIRE

Furqon, Muhammad Taufiq

2013-01-01

Furqon, Muhammad Taufiq. 2013. “Nilai Pendidikan dalam Komik One Piece Jilid 1-23 Karya Eiichiro Oda”. Skripsi S-1 Fakultas Ilmu Budaya Universitas Diponegoro Semarang. Permasalahan dalam penelitian ini adalah komik One Piece dilihat dari bentuknya hanya terdiri dari gambar dan teks, tetapi ada unsur-unsur fiksi terdapat di dalamnya seperti adanya tema, tokoh, latar,dan ada amanat yang ingin disampaikan pengarangnya. Sehingga pemahaman dan pemaknaan terhadapnya mampu memberikan manfaat bagi p...

Preconditioning Strategies for Solving Elliptic Difference Equations on a Multiprocessor.

Science.gov (United States)

1982-01-01

CALLING MA31C. C TD - TIME REQUIRED BY MA31C TO PERFORM THE C FACTORIZATION. 160 C TDT - TOTAL TIME REQUIRED BY SUBROUTINE FACTOR. C TDT-T IM3-T IMI...TPD-TIM2-TIM1 TD -TIM3-TIM2 165 C WRITE(LP,70) TDT,TPD, TD 70 FORMAT(7H TDT - ,F6.3,7H TPD " F6.3,6H TD ,F6.3) C WRITE(LP, 85) NTYPE,NVERN 170 85 FORMAT...INTEGER INI(IAI) ,INJ(IAJ) ,IK(NN,4) INTEGER NU(3000) C COMMON/EA 4BD /PRVT(4),IPRVT(6) 15 COMMON/MA31I/DD,LP,MP COMMON/MA31J/LROW,LCOL,NCP,ND, IPD

The Role of Transacademic Interface Managers in Transformational Sustainability Research and Education

Directory of Open Access Journals (Sweden)

Braden Kay

2013-10-01

Full Text Available Working towards sustainable solutions requires involving professionals and stakeholders from all sectors of society into research and teaching. This often presents a challenge to scholars at universities, as they lack capacity and time needed for negotiating different agendas, languages, competencies, and cultures among faculty, students, and stakeholders. Management approaches and quality criteria have been developed to cope with this challenge, including concepts of boundary organizations, transdisciplinary research, transition management, and interface management. However, few of these concepts present comprehensive proposals how to facilitate research with stakeholder participation while creating educational opportunities along the lifecycle of a project. The article focuses on the position of a transacademic interface manager (TIM supporting participatory sustainability research and education efforts. We conceptualize the task portfolio of a TIM; outline the capacities a TIM needs to possess in order to successfully operate; and propose an educational approach for how to train students in becoming a TIM. For this, we review the existing literature on TIMs and present insights from empirical sustainability research and educational projects that involved TIMs in different functions. The article provides practical guidance to universities on how to organize these critical endeavors more effectively and to offer students an additional career perspective.

Uranium(iii) complexes supported by hydrobis(mercaptoimidazolyl)borates: synthesis and oxidation chemistry.

Science.gov (United States)

Maria, Leonor; Santos, Isabel C; Santos, Isabel

2018-05-23

The reaction of [UI3(thf)4] with the sodium or lithium salts of hydrobis(2-mercapto-1-methylimidazolyl)borate ligands ([H(R)B(timMe)2]-) in a 1 : 2 ratio, in tetrahydrofuran, gave the U(iii) complexes [UI{κ3-H,S,S'-H(R)B(timMe)2}2(thf)2] (R = H (1), Ph (2)) in good yields. Crystals of [UI{κ3-H,S,S'-H(Ph)B(timMe)2}2(thf)2] (2) were obtained by recrystallization from a tetrahydrofuran/acetonitrile solution, and the ion-separated uranium complex [U{κ3-H,S,S'-H(Ph)B(timMe)2}2(CH3CN)3][I] (3-I) was obtained by dissolution of 2 in acetonitrile followed by recrystallization. One-electron oxidation of 2 with AgBPh4 or I2 resulted in the formation of the cationic U(iv) complexes [U{κ3-H,S,S'-H(Ph)B(timMe)2}3][X] (X = BPh4 (6-BPh4), I (6-I)), due to a ligand redistribution process. These complexes are the first examples of homoleptic poly(azolyl)borate U(iv) complexes. Treatment of complex 2 with azobenzene led to the isolation of crystals of the U(iv) compound [UI{κ3-H(Ph)B(timMe)2}2(κ2-timMe)] (7). Treatment of 2 with pyridine-N oxide (pyNO) led to the formation of the uranyl complex [UO2{κ2-S,S'-H(Ph)B(timMe)2}2] (8) and of complex 6-I, while from the reaction of [U{κ3-H(Ph)B(timMe)2}2(thf)3][BPh4] (5) with pyNO, the oxo-bridged U(iv) complex [{U{κ3-H(Ph)B(timMe)2}2(pyNO)}2(μ-O)][BPh4]2 (9) was also obtained. In the U(iii) and U(iv) complexes, the bis(azolyl)borate ligands bind to the uranium center in a κ3-H,S,S' coordination mode, while in the U(vi) complex the ligands bind to the metal in a κ2-S,S' mode. The presence of UH-B interactions in the solid-state, for the nine-coordinate complexes 1, 2, 3, 6 and 7 and for the eight-coordinate complex 9, was supported by IR spectroscopy and/or X-ray diffraction analysis.

Preparation of bone-implants by coating hydroxyapatite nanoparticles on self-formed titanium dioxide thin-layers on titanium metal surfaces.

Science.gov (United States)

Wijesinghe, W P S L; Mantilaka, M M M G P G; Chathuranga Senarathna, K G; Herath, H M T U; Premachandra, T N; Ranasinghe, C S K; Rajapakse, R P V J; Rajapakse, R M G; Edirisinghe, Mohan; Mahalingam, S; Bandara, I M C C D; Singh, Sanjleena

2016-06-01

Preparation of hydroxyapatite coated custom-made metallic bone-implants is very important for the replacement of injured bones of the body. Furthermore, these bone-implants are more stable under the corrosive environment of the body and biocompatible than bone-implants made up of pure metals and metal alloys. Herein, we describe a novel, simple and low-cost technique to prepare biocompatible hydroxyapatite coated titanium metal (TiM) implants through growth of self-formed TiO2 thin-layer (SFTL) on TiM via a heat treatment process. SFTL acts as a surface binder of HA nanoparticles in order to produce HA coated implants. Colloidal HA nanorods prepared by a novel surfactant-assisted synthesis method, have been coated on SFTL via atomized spray pyrolysis (ASP) technique. The corrosion behavior of the bare and surface-modified TiM (SMTiM) in a simulated body fluid (SBF) medium is also studied. The highest corrosion rate is found to be for the bare TiM plate, but the corrosion rate has been reduced with the heat-treatment of TiM due to the formation of SFTL. The lowest corrosion rate is recorded for the implant prepared by heat treatment of TiM at 700 °C. The HA-coating further assists in the passivation of the TiM in the SBF medium. Both SMTiM and HA coated SMTiM are noncytotoxic against osteoblast-like (HOS) cells and are in high-bioactivity. The overall production process of bone-implant described in this paper is in high economic value. Copyright © 2016 Elsevier B.V. All rights reserved.

Wyoming CV Pilot Traveler Information Message Sample

Data.gov (United States)

Department of Transportation — This dataset contains a sample of the sanitized Traveler Information Messages (TIM) being generated by the Wyoming Connected Vehicle (CV) Pilot. The full set of TIMs...

Kajian Teoritis dan Empiris Terhadap Perawatan Gedung di Indonesia

Directory of Open Access Journals (Sweden)

Suparno Suparno

2009-02-01

Full Text Available Sebagaimana juga dialami negara-negara maju yang telah banyak membangun gedung tinggi, persoalan yang muncul adalah bagaimana merawat bangunan tersebut. Pada satu sisi data atau pola kajian ilmiah tentang perawatan gedung di Indonesia masih sangat langka. Padahal data tersebut sangat penting artinya bagi pengembangan ilmu teknik sipil dan juga bagi pelaksana bangunan dalam melakukan kegiatan di lapangan. Kurang lengkapnya data-data tentang perawatan gedung, seharusnya mendorong para pakar bangunan untuk melakukan penelitian. Pada dasarnya perawatan gedung yang menyeluruh (total building maintenance meliputi aspek-aspek komponen elektrik, mekanikal, teknik sipil, pembersihan (cleaning, keamanan (security, dan pertamanan (landscaping. Kegiatan perawatan terhadap komponen-komponen dapat berupa pencegahan (protection, perbaikan (repairing, dan pembaharuan (renovation.

Trichoderma sp. dalam Pengendalian Penyakit Layu Fusarium pada Tanaman Tomat

OpenAIRE

Novita, Trias

2013-01-01

Penelitian ini bertujuan untuk mengetahui peran Trichoderma sp dalam pengendalianpenyakit layu fusarium pada tanaman tomat. Penelitian dilaksanakan di Rumah Kaca FakultasPertanian Universitas Jambi, perlakuannya terdiri dari : t0 = tanpa Trichoderma sp; t1 = 25 gTrichoderma sp/8 kg media; t2 = 50 g Trichoderma sp/8 kg media; t3 = 75 g Trichoderma sp/8 kgmedia; dan t4 = 100 g Trichoderma sp /8 kg media. Hasil penelitian menunjukkan bahwa Trichodermasp berperan dalam mengendalikan penyakit layu...

Aristotelovo pojetí logiky

OpenAIRE

Zavřel, Karel

2014-01-01

Bibliografická citace ZAVŘEL, Karel. Aristotelovo pojetí logiky. Bakalářská práce. Praha: Univerzita Karlova - Katolická teologická fakulta, 2014. Abstract Presented bachelor thesis Aristotle's conception of logic describes gradually Aristotle's life, the previous dialectical tradition and also concrete bases of his logical system. There are described in detail the various parts of Aristotle's Organon. The greatest emphasis is placed - and a large space is devoted - especially Aristotle's doc...

Pengaruh Berkumur Air Kelapa Muda Terhadap Ph Saliva

OpenAIRE

Mokoginta, Zuthra P

2017-01-01

PENGARUH BERKUMUR AIR KELAPA MUDA TERHADAP pH SALIVA Zuthra P. Mokoginta1) , Vonny N.S. Wowor1) , Juliatri1) 1)Program Studi Pendidikan Dokter Gigi, Fakultas Kedokteran UNSRAT Manado, 95115 ABSTRACT Saliva is one factor that contributes to the development of caries, particularly in the process of demineralization. The low pH in the oral cavity will facilitate the growth of acidogenic bacteria such as Streptococcus mutans and Lactobacillus which is the main cause microorganisms in th...

Analýza expozice antibakteriálními léčivy u pacientů s transplantací periferních kmenových buněk

OpenAIRE

Dobrovolný, Lukáš

2008-01-01

UNIVERZITA KARLOVA V PRAZE FARMACEUTICKÁ FAKULTA V HRADCI KRÁLOVÉ KATEDRA SOCIÁLNÍ A KLINICKÉ FARMACIE Abstract of diploma thesis Lukáš Dobrovolný 2008 The analysis of exposition of antibacterial drugs in patiens after stem cell transplantation The thesis focused on gaining the resistence level data connected with six most common microbial organisms isolated in Czech republic even through whole Europe. The uniqueness of the study flows from the characterisitics of analysed patients'group with...

Novel polymer composite having diamond particles and boron nitride platelets for thermal management of electric vehicle motors

Science.gov (United States)

Nakajima, Anri; Shoji, Atsushi; Yonemori, Kei; Seo, Nobuhide

2016-02-01

Thermal conductivities of silicone matrix polymers including fillers of diamond particles and/or hexagonal boron nitride (h-BN) platelets were systematically investigated in an attempt to find a thermal interface material (TIM) having high isotropic thermal conductivity and high electrical insulating ability to enable efficient heat dissipation from the motor coil ends of electric vehicles. The TIM with mixed fillers of diamond particles and h-BN platelets had a maximum thermal conductivity of 6.1 W m-1 K-1 that was almost isotropic. This is the highest value among the thermal conductivities of TIMs with silicone matrix polymer reported to date. The mechanism behind the thermal conductivity of the TIMs was also examined from the viewpoint of the change in the number of thermally conductive networks and/or a decrease in the thermal resistivity of junctions of neighboring diamond particles through the incorporation of h-BN platelets. The TIMs developed in this study will make it possible to manage the heat of electric motors and will help to popularize electric vehicles.

77 FR 27817 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Approving a Proposed Rule Change To List...

Science.gov (United States)

2012-05-11

... its parent company or its affiliates. See id. \\9\\ See email from Tim Malinowski, Senior Director, NYSE... IIV is no longer calculated or available as required. \\17\\ See email from Tim Malinowski, Senior...

Travoprost 0.004%/timolol 0.5%-fixed combination with and without benzalkonium chloride: a prospective, randomized, doubled-masked comparison of safety and efficacy.

Science.gov (United States)

Kitazawa, Y; Smith, P; Sasaki, N; Kotake, S; Bae, K; Iwamoto, Y

2011-09-01

The purpose of this study is to compare the safety and intraocular pressure (IOP)-lowering efficacy of travoprost/timolol in a benzalkonium chloride (BAK)-free fixed combination preserved with polyquaternium-1 (TRA/TIM BAK-free), with travoprost/timolol-fixed combination preserved with BAK (TRA/TIM), in patients with open-angle glaucoma or ocular hypertension. In this prospective randomized controlled trial, subjects with IOP of at least 22  mm Hg in one or both eyes at 0900  h, and IOP of at least 21  mm Hg in one or both eyes at 1100  h and 1600  h at two eligibility visits were randomly assigned to receive either TRA/TIM BAK-free (n=195) or TRA/TIM (n=193), dosed once daily in the morning (0900  h) for 6 weeks. IOP was assessed at 0900  h, 1100  h, and 1600  h at each scheduled visit (baseline, 2 and 6 weeks after randomization). Mean IOP reduction across all visits and time points was 8.0  mm Hg in the TRA/TIM BAK-free group and 8.4  mm Hg in the TRA/TIM group (P=0.0943). The difference in mean IOP between groups ranged from 0.2 to 0.7  mm Hg across visits and time points, with a mean pooled difference of 0.4  mm Hg (95% CI: -0.1 to 0.8), demonstrating equivalence of the two formulations. The most common drug-related adverse event was hyperemia of the eye (ocular hyperemia and conjunctival hyperemia combined), occurring in 11.8% of the TRA/TIM BAK-free group and 13.0% of the TRA/TIM group. Travoprost/timolol BAK-free demonstrated equivalence to travoprost/timolol preserved with BAK in efficacy. No clinically relevant differences in the safety profiles of travoprost/timolol BAK-free and travoprost/timolol preserved with BAK were identified.

Increased Expression of T Cell Immunoglobulin and Mucin Domain 3 on CD14+ Monocytes Is Associated with Systemic Inflammatory Reaction and Brain Injury in Patients with Spontaneous Intracerebral Hemorrhage.

Science.gov (United States)

Xu, ChangJun; Ge, HaiTao; Wang, Tao; Qin, JianBing; Liu, De; Liu, YuGuang

2018-05-01

To study the expression of T cell immunoglobulin and mucin domain 3 (Tim-3) on peripheral blood immunocytes, and the relationship between Tim-3 and the systemic inflammatory response or brain injury in patients with intracerebral hemorrhage (ICH). According to the volume of hematoma at 12 hours after onset of ICH, 60 newly diagnosed patients with ICH were divided into the small (volume of hematoma <30 mL, 30 cases) and large (volume of hematoma ≥30 mL, 30 cases) ICH groups. The expression of Tim-3 on peripheral blood immunocytes was analyzed by flow cytometry. Real-time reverse transcriptase polymerase chain reaction was used to detect Tim-3 mRNA on peripheral blood mononuclear cells (PBMCs). Meanwhile, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and S-100B protein were measured by enzyme-linked immunosorbent assay. Glasgow outcome scale (GOS) score at Day 30 was used to estimate prognosis of patients. The leukocyte count, neutrophil count, monocyte count, TNF-α, IL-1β, and S-100B protein increased remarkably after ICH. However, all of them in the large ICH group increased more obviously, and there were significant differences when compared with those in the small ICH group (P < .01). The expression of Tim-3 mRNA on PBMCs in the large ICH group increased remarkably, peaked at Day 3, and was positively associated with the concentrations of TNF-α, IL-1β, and S-100B protein (P < .01). Tim-3 was predominantly expressed itself on CD14 + monocytes. There was a negative correlation between GOS score and Tim-3 mRNA, TNF-α, IL-1β, or S-100B protein. The expression of Tim-3 on CD14 + monocytes involves in systemic inflammatory reaction after ICH and may be a novel treatment target. Copyright © 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Making the connection: advancing traffic incident management in transportation planning : a primer.

Science.gov (United States)

2013-07-01

"The intent of this primer is to inform and guide traffic incident management (TIM) professionals and transportation planners to initiate and develop collaborative relationships and advance TIM programs through the metropolitan planning process. The ...

Respon pertumbuhan bibit kakao (Theobroma cacao L.) terhadap pemberian pupuk guano dan KCl

OpenAIRE

Rajagukguk, Pispa

2015-01-01

Addition of Guano in Cultivation of Cacao Seedling is the one of step to use organic fertilizer that comes from animal feces in the world. For that purpose addition guano aims to increase growth of Cacao in Cultivation of Seedling. This research had been conducted at experimental field of Fakultas Pertanian USU in October 2013 - January 2014 using factorial randomized block design with two factor, i.e. addition dose of Guano (0, 75 , 150 , 225 g/polibag) and dose of KCl (0 , ...

Perbedaan Pelepasan Ion Nikel Dan Kromium Pada Beberapa Merek Kawat Stainless Steel Yang Direndam Dalam Asam Cuka

OpenAIRE

Situmeang, Meri Angelia

2016-01-01

PERBEDAAN PELEPASAN ION NIKEL DAN KROMIUM PADA BEBERAPA MEREK KAWAT STAINLESS STEEL YANG DIRENDAM DALAM ASAM CUKA Meri Angelia Situmeang1), P. S. Anindita 1), Juliatri1) 1)Program Studi Pendidikan Dokter Gigi Fakultas Kedokteran UNSRAT Manado, 95115 ABSTRACT Wire is one of the important components in the orthodontic treatment. Orthodontic wire inside the oral cavity can trigger the release of metal ions when contact with an environment that has an acidic pH. One type of wire used in ortho...

STRATEGI PENINGKATAN MUTU PERGURUAN TINGGI AGAMA ISLAM BERBASIS BALANCED SCORECARD

Directory of Open Access Journals (Sweden)

Machasin Machasin

2011-12-01

Kajian ini merupakan kajian kebijakan, yang menggunakan STAIN di Jawa Tengah sebagai obyek penelitian, dengan pejabat fakultas, mahasiswa, pegawai, dan lulusan yang menjadi obyek analisis. Teknik analisis yang digunakan adalah deskriptif eksploratif, dengan perspektif stakeholder, pejabat administratif dan keuangan, proses belajar mengajar, etos kerja, budaya, dan dan good governance. Hasil dari lima perspektif ini menunjukkan adanya perbedaan implementasi, sementara dari perspektif pengelola administrasi dan keuangan menghadapi masalah yang sama yaitu tidak optimalnya unit-unit perawatan sehingga masih kecil kontribusinya bagi perolehan STAIN.

Preparation of bone-implants by coating hydroxyapatite nanoparticles on self-formed titanium dioxide thin-layers on titanium metal surfaces

Energy Technology Data Exchange (ETDEWEB)

Wijesinghe, W.P.S.L.; Mantilaka, M.M.M.G.P.G.; Chathuranga Senarathna, K.G. [Department of Chemistry, Faculty of Science, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Postgraduate Institute of Science, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Herath, H.M.T.U. [Postgraduate Institute of Science, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Premachandra, T.N. [Department of Veterinary Pathobiology, Faculty of Veterinary Medicine, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Ranasinghe, C.S.K. [Department of Chemistry, Faculty of Science, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Postgraduate Institute of Science, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Rajapakse, R.P.V.J. [Postgraduate Institute of Science, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Department of Veterinary Pathobiology, Faculty of Veterinary Medicine, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Rajapakse, R.M.G., E-mail: rmgr@pdn.ac.lk [Department of Chemistry, Faculty of Science, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Postgraduate Institute of Science, University of Peradeniya, 20400 Peradeniya (Sri Lanka); Edirisinghe, Mohan; Mahalingam, S. [Department of Mechanical Engineering, University College London, London WC1E 7JE (United Kingdom); Bandara, I.M.C.C.D. [School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, 2 George Street, Brisbane 4001, QLD (Australia); Singh, Sanjleena [Central Analytical Research Facility, Institute of Future Environments, Queensland University of Technology, 2 George Street, Brisbane 4001, QLD (Australia)

2016-06-01

Preparation of hydroxyapatite coated custom-made metallic bone-implants is very important for the replacement of injured bones of the body. Furthermore, these bone-implants are more stable under the corrosive environment of the body and biocompatible than bone-implants made up of pure metals and metal alloys. Herein, we describe a novel, simple and low-cost technique to prepare biocompatible hydroxyapatite coated titanium metal (TiM) implants through growth of self-formed TiO{sub 2} thin-layer (SFTL) on TiM via a heat treatment process. SFTL acts as a surface binder of HA nanoparticles in order to produce HA coated implants. Colloidal HA nanorods prepared by a novel surfactant-assisted synthesis method, have been coated on SFTL via atomized spray pyrolysis (ASP) technique. The corrosion behavior of the bare and surface-modified TiM (SMTiM) in a simulated body fluid (SBF) medium is also studied. The highest corrosion rate is found to be for the bare TiM plate, but the corrosion rate has been reduced with the heat-treatment of TiM due to the formation of SFTL. The lowest corrosion rate is recorded for the implant prepared by heat treatment of TiM at 700 °C. The HA-coating further assists in the passivation of the TiM in the SBF medium. Both SMTiM and HA coated SMTiM are noncytotoxic against osteoblast-like (HOS) cells and are in high-bioactivity. The overall production process of bone-implant described in this paper is in high economic value. - Highlights: • Colloidal hydroxyapatite nanorods are prepared by a novel method. • Surfaces of titanium metal plates are modified by self-forming TiO{sub 2} thin-films. • Prostheses are prepared by coating hydroxyapatite on surface modified Ti metal. • Bioactivity and noncytotoxicity are increased with surface modifications.

Perturbation of the dimer interface of triosephosphate isomerase and its effect on Trypanosoma cruzi.

Directory of Open Access Journals (Sweden)

Vanesa Olivares-Illana

2007-10-01

Full Text Available Chagas disease affects around 18 million people in the American continent. Unfortunately, there is no satisfactory treatment for the disease. The drugs currently used are not specific and exert serious toxic effects. Thus, there is an urgent need for drugs that are effective. Looking for molecules to eliminate the parasite, we have targeted a central enzyme of the glycolytic pathway: triosephosphate isomerase (TIM. The homodimeric enzyme is catalytically active only as a dimer. Because there are significant differences in the interface of the enzymes from the parasite and humans, we searched for small molecules that specifically disrupt contact between the two subunits of the enzyme from Trypanosoma cruzi but not those of TIM from Homo sapiens (HTIM, and tested if they kill the parasite.Dithiodianiline (DTDA at nanomolar concentrations completely inactivates recombinant TIM of T. cruzi (TcTIM. It also inactivated HTIM, but at concentrations around 400 times higher. DTDA was also tested on four TcTIM mutants with each of its four cysteines replaced with either valine or alanine. The sensitivity of the mutants to DTDA was markedly similar to that of the wild type. The crystal structure of the TcTIM soaked in DTDA at 2.15 A resolution, and the data on the mutants showed that inactivation resulted from alterations of the dimer interface. DTDA also prevented the growth of Escherichia coli cells transformed with TcTIM, had no effect on normal E. coli, and also killed T. cruzi epimastigotes in culture.By targeting on the dimer interface of oligomeric enzymes from parasites, it is possible to discover small molecules that selectively thwart the life of the parasite. Also, the conformational changes that DTDA induces in the dimer interface of the trypanosomal enzyme are unique and identify a region of the interface that could be targeted for drug discovery.

Autologous Stem Cell Transplantation in Patients With Multiple Myeloma: An Activity-based Costing Analysis, Comparing a Total Inpatient Model Versus an Early Discharge Model.

Science.gov (United States)

Martino, Massimo; Console, Giuseppe; Russo, Letteria; Meliado', Antonella; Meliambro, Nicola; Moscato, Tiziana; Irrera, Giuseppe; Messina, Giuseppe; Pontari, Antonella; Morabito, Fortunato

2017-08-01

Activity-based costing (ABC) was developed and advocated as a means of overcoming the systematic distortions of traditional cost accounting. We calculated the cost of high-dose chemotherapy and autologous stem cell transplantation (ASCT) in patients with multiple myeloma using the ABC method, through 2 different care models: the total inpatient model (TIM) and the early-discharge outpatient model (EDOM) and compared this with the approved diagnosis related-groups (DRG) Italian tariffs. The TIM and EDOM models involved a total cost of €28,615.15 and €16,499.43, respectively. In the TIM model, the phase with the greatest economic impact was the posttransplant (recovery and hematologic engraftment) with 36.4% of the total cost, whereas in the EDOM model, the phase with the greatest economic impact was the pretransplant (chemo-mobilization, apheresis procedure, cryopreservation, and storage) phase, with 60.4% of total expenses. In an analysis of each episode, the TIM model comprised a higher absorption than the EDOM. In particular, the posttransplant represented 36.4% of the total costs in the TIM and 17.7% in EDOM model, respectively. The estimated reduction in cost per patient using an EDOM model was over €12,115.72. The repayment of the DRG in Calabrian Region for the ASCT procedure is €59,806. Given the real cost of the transplant, the estimated cost saving per patient is €31,190.85 in the TIM model and €43,306.57 in the EDOM model. In conclusion, the actual repayment of the DRG does not correspond to the real cost of the ASCT procedure in Italy. Moreover, using the EDOM, the cost of ASCT is approximately the half of the TIM model. Copyright © 2017 Elsevier Inc. All rights reserved.

Preparation of bone-implants by coating hydroxyapatite nanoparticles on self-formed titanium dioxide thin-layers on titanium metal surfaces

International Nuclear Information System (INIS)

Wijesinghe, W.P.S.L.; Mantilaka, M.M.M.G.P.G.; Chathuranga Senarathna, K.G.; Herath, H.M.T.U.; Premachandra, T.N.; Ranasinghe, C.S.K.; Rajapakse, R.P.V.J.; Rajapakse, R.M.G.; Edirisinghe, Mohan; Mahalingam, S.; Bandara, I.M.C.C.D.; Singh, Sanjleena

2016-01-01

Preparation of hydroxyapatite coated custom-made metallic bone-implants is very important for the replacement of injured bones of the body. Furthermore, these bone-implants are more stable under the corrosive environment of the body and biocompatible than bone-implants made up of pure metals and metal alloys. Herein, we describe a novel, simple and low-cost technique to prepare biocompatible hydroxyapatite coated titanium metal (TiM) implants through growth of self-formed TiO_2 thin-layer (SFTL) on TiM via a heat treatment process. SFTL acts as a surface binder of HA nanoparticles in order to produce HA coated implants. Colloidal HA nanorods prepared by a novel surfactant-assisted synthesis method, have been coated on SFTL via atomized spray pyrolysis (ASP) technique. The corrosion behavior of the bare and surface-modified TiM (SMTiM) in a simulated body fluid (SBF) medium is also studied. The highest corrosion rate is found to be for the bare TiM plate, but the corrosion rate has been reduced with the heat-treatment of TiM due to the formation of SFTL. The lowest corrosion rate is recorded for the implant prepared by heat treatment of TiM at 700 °C. The HA-coating further assists in the passivation of the TiM in the SBF medium. Both SMTiM and HA coated SMTiM are noncytotoxic against osteoblast-like (HOS) cells and are in high-bioactivity. The overall production process of bone-implant described in this paper is in high economic value. - Highlights: • Colloidal hydroxyapatite nanorods are prepared by a novel method. • Surfaces of titanium metal plates are modified by self-forming TiO_2 thin-films. • Prostheses are prepared by coating hydroxyapatite on surface modified Ti metal. • Bioactivity and noncytotoxicity are increased with surface modifications.

Interspecific studies of circadian genes period and timeless in Drosophila.

Science.gov (United States)

Noreen, Shumaila; Pegoraro, Mirko; Nouroz, Faisal; Tauber, Eran; Kyriacou, Charalambos P

2018-03-30

The level of rescue of clock function in genetically arrhythmic Drosophila melanogaster hosts using interspecific clock gene transformation was used to study the putative intermolecular coevolution between interacting clock proteins. Among them PER and TIM are the two important negative regulators of the circadian clock feedback loop. We transformed either the D. pseudoobscura per or tim transgenes into the corresponding arrhythmic D. melanogaster mutant (per01 or tim01) and observed >50% rhythmicity but the period of activity rhythm was either longer (D. pseudoobscura-per) or shorter than 24 h (D. pseudoobscura-tim) compared to controls. By introducing both transgenes simultaneously into double mutants, we observed that the period of the activity rhythm was rescued by the pair of hemizygous transgenes (~24 h). These flies also showed a more optimal level of temperature compensation for the period. Under LD 12:12 these flies have a D. pseudoobscura like activity profile with the absence of morning anticipation as well as a very prominent earlier evening peak of activity rhythm. These observation are consistent with the view that TIM and PER form a heterospecific coevolved module at least for the circadian period of activity rhythms. However the strength of rhythmicity was reduced by having both transgenes present, so while evidence for a coevolution between PER and TIM is observed for some characters it is not for others. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Efficacy and Safety of Switching Prostaglandin Analog Monotherapy to Tafluprost/Timolol Fixed-Combination Therapy

Science.gov (United States)

Kitamura, Kazuyoshi; Chiba, Tatsuya; Mabuchi, Fumihiko; Ishijima, Kiyotaka; Omoto, Shu; Kashiwagi, Fumiko; Godo, Takashi; Kogure, Satoshi; Goto, Teruhiko; Shibuya, Takashi; Tanabe, Jhoji; Tsukahara, Shigeo; Tsuchiya, Tadaharu; Tokunaga, Takaharu; Hosaka, Osamu; Saito, Tetsunori

2018-01-01

Purpose To assess the efficacy and safety of switching from prostaglandin analog (PGA) monotherapy to tafluprost/timolol fixed-combination (Taf/Tim) therapy. Subjects and Methods Patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who had received PGA monotherapy for at least 3 months were enrolled. Patients were examined at 1, 2, and 3 months after changing therapies. Subsequently, the patients were returned to PGA monotherapy. The examined parameters included intraocular pressure (IOP) and adverse events. A questionnaire survey was conducted after the switch to Taf/Tim therapy. Results Forty patients with a mean age of 66.5 ± 10.3 years were enrolled; 39 of these patients completed the study protocol. Switching to Taf/Tim significantly reduced the IOP from 18.2 ± 2.6 mmHg at baseline to 14.8 ± 2.5 mmHg at 1 month, 15.2 ± 2.8 mmHg at 2 months, and 14.9 ± 2.5 mmHg at 3 months (P Taf/Tim reduced the pulse rate insignificantly. No significant differences were observed in blood pressure, conjunctival hyperemia, or corneal adverse events. A questionnaire showed that the introduction of Taf/Tim did not significantly influence symptoms. Conclusions Compared with PGA monotherapy, Taf/Tim fixed-combination therapy significantly reduced IOP without severe adverse events. PMID:29675274

Stable isotope dilution analysis by thermal ionization mass spectrometry. Pt. 2

International Nuclear Information System (INIS)

Broekman, A.; Raaphorst, J.G. van

1984-01-01

The combination of stable isotope dilution analysis (SIDA) and thermal ionization mass spectrometry (TIMS) is in use for lead and uranium determination at milligram per kilogram levels for over 20 years. However, several other elements can also be determined accurately by SIDA/TIMS. In this study the determinations of cadmium and copper are described. Details of the digestion, electrochemical and ion-exchange separations and the loading of the elements on a filament are given. The advantages of the SIDA/TIMS technique are shown and illustrated with results for several certified reference materials. (orig.) [de

TRACER STUDY FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA

Directory of Open Access Journals (Sweden)

Darma Rika Swaramarinda

2014-03-01

Full Text Available This study was conducted to identify the competencies of graduates FE UNJ waiting times based upon the profile of the work , the suitability of the first areas of work, salary and perceptions about the competence of the alumni corporation. This research is a qualitative study and the population are alumni of the Faculty of Economics who working in government agencies, private and entrepreneur and graduated from the period 2011/2012 to 2012/2013. Sample of the population is set at 10 % of the total population, and using a technique convenience sampling ( non probability sampling . The data used in this study is primary data obtained from interviews and use the questionnaire instrument. Data were analyzed using descriptive statistics by looking at the frequency distribution and the average of respondents answers regarding the competence of graduates of the Faculty of Economics UNJ. 92.8% of alumni of the Faculty of Economics working as employees of the company, 5.8 % be a teacher, others go to college and as entrepreneurs . The average waiting time for alumni FE UNJ only takes waited less than 6 months to get a job. The level of salary received at the time of the first alumni of work varies with an average of 2-3 million by 49 % and between 3 million and above by 23 % . The level of compliance competencies and job average amounted to 77 % of alumni and competence of alumni based on the user 's perception was expressed by 71 % of alumni FE UNJ have a good competence.

Plutarque, Sur l' E de Delphes 390 B 6-8 et l'explication de  la vision en Timée 45 b-d*

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Alain Lernould

2005-04-01

Full Text Available Le traité (ou dialogue « pythique » du platonicien Plutarque de Chéronée (Iier – IIe s. ap. J.-C. intitulé Sur l’E de Delphes est consacré à l’élucidation de la signification de l’E (la cinquième lettre de l’alphabet grec consacré à Apollon Pythien. Une des interprétations (d’inspiration pythagoricienne est que cet E désigne le nombre cinq, le nombre de l’univers. Dans le cadre de l’exposé de cette interprétation est fait état de l’opinion « de certains » selon laquelle il existe une correspondance entre les cinq sens et les cinq éléments. L’A. montre que les deux lignes où il est question de la vue (E 390b6-8 s’inspirent essentiellement de l’explication qu’en Timée 45b-d Platon donne du mécanisme de la vision en termes de mélange du feu pur émis par l’œil avec le feu pur extérieur qui produit la lumière du jour. L’extrême brièveté de ce résumé (empreint d’aristotélisme, l’élément associé à la vue étant ici l’éther considéré comme cinquième corps, d’un passage dans Platon offrant lui-même bon nombre de difficultés, explique que ces deux lignes énigmatiques n’aient jamais été bien comprises. Au passage, l’A. revient sur les notions d’homoiopatheia (d’homogénéité et de summetria (de commensurabilité en Timée 45b-d et 67c-e pour en proposer une interprétation qui souligne et éclaire d’un jour nouveau le caractère dynamique de l’explication platonicienne de la vision. Un Appendice donne un aperçu des différentes lectures d’E 390b6-8 depuis les premières éditions imprimées à la Renaissance jusqu’aux éditions critiques des 19e et 20e siècles.The essay (or dialogue On the E at Delphi of the Platonist Plutarch of Chaeronea (c. 50 – c. 125 A.D. is devoted to the elucidation of the mysterious E – the fifth letter of the Greek alphabet – that is dedicated to Apollo. According to one interpretation the E is, in a Pythagorean

INTERIM RESULTS FROM A STUDY OF THE IMPACTS OF TIN(II) BASED MERCURY TREATMENT IN A SMALL STREAM ECOSYSTEM: TIMS BRANCH, SAVANNAH RIVER SITE

Energy Technology Data Exchange (ETDEWEB)

Looney, B.; Bryan, L.; Mathews, T.

2012-03-30

source control measures have resulted in rapid responses in lake or reservoir fisheries (Joslin 1994, Turner and Southworth 1999; Orihel et al., 2007), but examples of similar responses in Hg-contaminated stream ecosystems are less common. Recent work suggests that stream systems may actually be more susceptible to mercury bioaccumulation than lakes, highlighting the need to better understand the ecological drivers of mercury bioaccumulation in stream-dwelling fish (Chasar et al. 2009, Ward et al. 2010). In the present study we examine the response of fish to remedial actions in Tims Branch, a point-source contaminated stream on the Department of Energy's (DOE) Savannah River Site in Aiken, South Carolina. This second order stream received inorganic mercury inputs at its headwaters from the 1950s-2000s which contaminated the water, sediments, and biota downstream. In 2007, an innovative mercury removal system using tin (II) chloride (stannous chloride, SnCl{sub 2}) was implemented at a pre-existing air stripper. Tin(II) reduces dissolved Hg (II) to Hg (0), which is removed by the air stripper. During this process, tin(II) is oxidized to tin (IV) which is expected to precipitate as colloidal tin(IV) oxides and hydroxides, particulate materials with relatively low toxicity (Hallas and Cooney, 1981, EPA 2002, ATSDR, 2005). The objectives of the present research are to provide an initial assessment of the net impacts of the tin(II) based mercury treatment on key biota and to document the distribution and fate of inorganic tin in this small stream ecosystem after the first several years of operating a full scale system. To support these objectives, we collected fish, sediment, water, invertebrates, and biofilm samples from Tims Branch to quantify the general behavior and accumulation patterns for mercury and tin in the ecosystem and to determine if the treatment process has resulted in: (1) a measurable beneficial impact on (i.e., decrease of) mercury concentration in

Virtuozita a performance maskulinity: Hudební etnografie jednoho pražského neromského gypsy jazzového uskupení

OpenAIRE

Kašparová, Žofie

2015-01-01

Univerzita Karlova v Praze, Filozofická fakulta Ústav hudební vědy Virtuosity and Performance of Masculinity: Music Ethnography of a Non-Roma Gypsy Jazz Group in Prague Žofie Kašparová 2014 Abstract In this ethnography I examine the gypsy jazz band Sylvanio Orchestra which is based in Prague, Czech Republic. This research consists largely of my observations at their performances, interviews with the band members as well as my personal experience of being a musician and a woman in this predomi...

Application of a dynamic in vitro gastrointestinal tract model to study the availability of food mutagens, using heterocyclic aromatic amines as model compounds

NARCIS (Netherlands)

Krul, C.A.M.; Luiten-Schuite, A.; Baan, R.; Verhagen, H.; Mohn, G.; Feron, V.; Havenaar, R.

2000-01-01

The TNO gastro-Intestinal tract Model (TIM) is a dynamic computer-controlled in vitro system that mimics the human physiological conditions in the stomach and small intestine. In the current TIM physiological parameters such as pH, temperature, peristaltic movements, secretion of digestion enzymes,

Carbon nanotube thermal interfaces and related applications

Science.gov (United States)

Hodson, Stephen L.

The development of thermal interface materials (TIMs) is necessitated by the temperature drop across interfacing materials arising from macro and microscopic irregularities of their surfaces that constricts heat through small contact regions as well as mismatches in their thermal properties. Similar to other types of TIMs, CNT TIMs alleviate the thermal resistance across the interface by thermally bridging two materials together with cylindrical, high-aspect ratio, and nominally vertical conducting elements. Within the community of TIM engineers, the vision driving the development of CNT TIMs was born from measurements that revealed impressively high thermal conductivities of individual CNTs. This vision was then projected to efforts focused on packing many individual CNTs on a single substrate that efficiently conduct heat in parallel and ultimately through many contact regions at CNT-to-substrate contacts. This thesis encompasses a comprehensive investigation of the viability of carbon nanotube based thermal interface materials (CNT TIMs) to efficiently conduct heat across two contacting materials. The efforts in this work were initially devoted to engaging CNT TIMs with an opposing substrate using two bonding techniques. Using palladium hexadecanethiolate, Pd(SC16H35)2 the CNT ends were bonded to an opposing substrate (one-sided interface) or opposing CNT array (two-sided interface) to enhance contact conductance while maintaining a compliant joint. The palladium weld is particularly attractive for its mechanical stability at high temperatures. The engagement of CNT TIMs with an opposing substrate was also achieved by inserting a solder foil between the CNT TIM and opposing substrate and subsequently raising the temperature of the interface above the eutectic point of the solder foil. This bonding technique creates a strong weld that not only reduces the thermal resistance significantly but also minimizes the change in thermal resistance with an applied

SUKU FABACEAE DI KAMPUS UNIVERSITAS ISLAM NEGERI SYARIF HIDAYATULLAH, JAKARTA, BAGIAN 2: TUMBUHAN POLONG BERPERAWAKAN TERNA

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Priyanti Priyanti

2017-04-01

Full Text Available Abstrak Suku Fabaceae adalah tetumbuhan yang memiliki buah bertipe polong. Suku tersebut selain berperawakan pohon juga berupa terna. Anggota suku Fabaceae (polong banyak ditemukan di sekitar lingkungan manusia termasuk di Kampus Universitas Islam Negeri (UIN Syarif Hidayatullah, Jakarta. Informasi mengenai keanekaragaman tumbuhan polong yang berupa terna di Kampus UIN Syarif Hidayatullah belum tersedia. Penelitian dilakukan menggunakan metode jelajah di kampus I dan II serta studi pustaka. Sebanyak 3 jenis tumbuhan polong berperawakan terna telah didapatkan di lingkungan kampus, yaitu Arachis pintoi Krapov. & W. C. Greg., Mimosa diplotricha C. Wright ex Sauvalle, dan M. pudica L. Jenis-jenis tersebut termasuk ke dalam 2 anak suku (Faboideae, Mimosoideae dan 2 puak (Aeschynomeneae, Mimoseae. Jenis-jenis tersebut tumbuh di lokasi yang berbeda-beda. Tumbuhan polong yang hanya ditemukan di Fakultas Kedokteran dan Ilmu Keshatan (FKIK adalah A. pintoi. Mimosa diplotricha ditemukan tumbuh di Pusat Laboratorium Terpadu Fakultas Sains dan Teknologi, Perpustakaan Utama, FKIK, Fakultas Sosial dan Ilmu Politik (FISIP, Wisma Syahida, Pusat Bahasa, dan Sekolah Pascasarjana, sedangkan M. pudica ditemukan Perpustakaan Utama, FISIP, dan Wisma Syahida. Kelengkapan data tentang tumbuhan polong di Kampus UIN Syarif Hidayatullah ini dapat digunakan oleh para mahasiswa untuk mempelajari keanekaragamnnya. Abstract Fabaceae is a plant with a pod-type fruit. A Habit of this family is not only trees but also herb. Fabaceae (legumes is often found on the human environment around campus included in the State Islamic University (UIN Syarif Hidayatullah, Jakarta. The Information about the legume herbs diversity on the UIN Syarif Hidayatullah yet available. The study was conducted using survey and literature methods. There were 3 species legume herbs in the campus, viz. Arachis pintoi Krapov. & W. C. Greg., Mimosa diplotricha C. Wright ex Sauvalle, and M. pudica L. All

Army Aviation’s Pacific Rebalance: Evolution Towards Maritime Operations

Science.gov (United States)

2016-05-26

A with Army Aviation Program Executive Officer Tim Crosby ," Rotor & Wing Magazine, July 2012, accessed August 21, 2015, http...Executive Officer Tim Crosby ." Rotor & Wing Magazine, July 2012. Accessed August 21, 2015. http://accessintelligence.imirus. com/Mpowered/book/vrw12/i7/p56

Astrocyte galectin-9 potentiates microglial TNF secretion.

Science.gov (United States)

Steelman, Andrew J; Li, Jianrong

2014-08-27

Aberrant neuroinflammation is suspected to contribute to the pathogenesis of myriad neurological diseases. As such, determining the pathways that promote or inhibit glial activation is of interest. Activation of the surface glycoprotein T-cell immunoglobulin and mucin-domain containing protein 3 (Tim-3) by the lectin galectin-9 has been implicated in promoting innate immune cell activation by potentiating or synergizing toll-like receptor (TLR) signaling. In the present study we examined the role of the Tim-3/galectin-9 pathway in glial activation in vitro. Primary monocultures of microglia or astrocytes, co-cultures containing microglia and astrocytes, and mixed glial cultures consisting of microglia, astrocytes and oligodendrocytes were stimulated with poly(I:C) or LPS, and galectin-9 up-regulation was determined. The effect of endogenous galectin-9 production on microglial activation was examined using cultures from wild-type and Lgals9 null mice. The ability for recombinant galectin-9 to promote microglia activation was also assessed. Tim-3 expression on microglia and BV2 cells was examined by qPCR and flow cytometry and its necessity in transducing the galectin-9 signal was determined using a Tim-3 specific neutralizing antibody or recombinant soluble Tim-3. Astrocytes potentiated TNF production from microglia following TLR stimulation. Poly(I:C) stimulation increased galectin-9 expression in microglia and microglial-derived factors promoted galectin-9 up-regulation in astrocytes. Astrocyte-derived galectin-9 in turn enhanced microglial TNF production. Similarly, recombinant galectin-9 enhanced poly(I:C)-induced microglial TNF and IL-6 production. Inhibition of Tim-3 did not alter TNF production in mixed glial cultures stimulated with poly(I:C). Galectin-9 functions as an astrocyte-microglia communication signal and promotes cytokine production from microglia in a Tim-3 independent manner. Activation of CNS galectin-9 likely modulates neuroinflammatory

Bitcoin and Beyond: Exclusively Informational Money

NARCIS (Netherlands)

Bergstra, J.A.; de Leeuw, K.

2013-01-01

The famous new money Bitcoin is classified as a technical informational money (TIM). Besides introducing the idea of a TIM, a more extreme notion of informational money will be developed: exclusively informational money (EXIM). The informational coins (INCOs) of an EXIM can be in control of an agent

Shoot growth processes, assessed by bud development types, reflect Norway spruce vitality and sink prioritization

Czech Academy of Sciences Publication Activity Database

Polák, T.; Rock, B. N.; Campbell, P.E.; Soukupová, J.; Šolcová, Blanka; Zvára, K.; Albrechtová, Jana

2006-01-01

Roč. 225, 1-3 (2006), s. 337-348 ISSN 0378-1127 R&D Projects: GA MŠk ME 658 Grant - others:Univerzita Karlova v Praze / Přírodovědecká fakulta(CZ) KJB6111307 Institutional research plan: CEZ:AV0Z50380511; CEZ:AV0Z60050516 Source of funding: V - iné verejné zdroje ; V - iné verejné zdroje Keywords : tree vitality * buds * carbon allocation * sink/source concept Subject RIV: GK - Forestry Impact factor: 1.839, year: 2006 http://dx.doi.org/10.1016/j.foreco.2006.01.027

Evaluation of lead isotope compositions of NIST NBS 981 measured by thermal ionization mass spectrometer and multiple-collector inductively coupled plasma mass spectrometer

Directory of Open Access Journals (Sweden)

Honglin Yuan

2016-09-01

Full Text Available Because Pb isotopes can be used for tracing, they are widely used in many disciplines. The detection and analysis of Pb isotopes of bulk samples are usually conducted using thermal ionization mass spectrometer (TIMS and multiple-collector inductively coupled plasma mass spectrometer (MC-ICP-MS, both of which need external reference materials with known isotopic compositions to correct for the mass discrimination effect produced during analysis. NIST NBS 981 is the most widely used reference material for Pb isotope analysis; however, the isotopic compositions reported by various analytical laboratories, especially those using TIMS, vary from each other. In this study, we statistically evaluated 229 reported TIMS analysis values collected by GeoReM in the last 30 years, 176 reported MC-ICP-MS analysis values, and 938 MC-ICP-MS analysis results from our laboratory in the last five years. After careful investigation, only 40 TIMS results were found to have double or triple spikes. The ratios of the overall weighted averages, 206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb, obtained from 40 spiked TIMS reports and 1114 MC-ICP-MS results of NIST NBS 981 isotopes were 16.9406 ± 0.0003 (2s, 15.4957 ± 0.0002 (2s, and 36.7184 ± 0.0007 (2s, respectively.

Conjugated Bilirubin Differentially Regulates CD4+ T Effector Cells and T Regulatory Cell Function through Outside-In and Inside-Out Mechanisms: The Effects of HAV Cell Surface Receptor and Intracellular Signaling

Science.gov (United States)

Corral-Jara, Karla F.; Gómez-Leyva, Juan F.; Rosenstein, Yvonne; Jose-Abrego, Alexis; Roman, Sonia

2016-01-01

We recently reported an immune-modulatory role of conjugated bilirubin (CB) in hepatitis A virus (HAV) infection. During this infection the immune response relies on CD4+ T lymphocytes (TLs) and it may be affected by the interaction of HAV with its cellular receptor (HAVCR1/TIM-1) on T cell surface. How CB might affect T cell function during HAV infection remains to be elucidated. Herein, in vitro stimulation of CD4+ TLs from healthy donors with CB resulted in a decrease in the degree of intracellular tyrosine phosphorylation and an increase in the activity of T regulatory cells (Tregs) expressing HAVCR1/TIM-1. A comparison between CD4+ TLs from healthy donors and HAV-infected patients revealed changes in the TCR signaling pathway relative to changes in CB levels. The proportion of CD4+CD25+ TLs increased in patients with low CB serum levels and an increase in the percentage of Tregs expressing HAVCR1/TIM-1 was found in HAV-infected patients relative to controls. A low frequency of 157insMTTTVP insertion in the viral receptor gene HAVCR1/TIM-1 was found in patients and controls. Our data revealed that, during HAV infection, CB differentially regulates CD4+ TLs and Tregs functions by modulating intracellular pathways and by inducing changes in the proportion of Tregs expressing HAVCR1/TIM-1. PMID:27578921

Pop / Tõnu Kaalep

Index Scriptorium Estoniae

Kaalep, Tõnu, 1966-2018

2007-01-01

Heliplaatidest: Tunnetusüksus "Ida ja Lääne vahel / Between East and West", Amy Winehouse "Back to Black", Kylie "Showgirl: Homecoming Live", Pet Shop Boys "Concrete", Gang Starr "Mass Appeal: The Best Of", Kling Klang "The Esthetik of Destruction", Clipse "Hell Hath NoFury", Tim Buckley "The Best of Tim Buckley"

Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans.

Science.gov (United States)

Wu, Tongzhi; Zhao, Beiyi R; Bound, Michelle J; Checklin, Helen L; Bellon, Max; Little, Tanya J; Young, Richard L; Jones, Karen L; Horowitz, Michael; Rayner, Christopher K

2012-01-01

Macronutrient "preloads" can stimulate glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), slow gastric emptying, and reduce postprandial glycemic excursions. After sweet preloads, these effects may be signaled by sodium-glucose cotransporter-1 (SGLT1), sweet taste receptors, or both. We determined the effects of 4 sweet preloads on GIP and GLP-1 release, gastric emptying, and postprandial glycemia. Ten healthy subjects were studied on 4 separate occasions each. A preload drink containing 40 g glucose, 40 g tagatose/isomalt mixture (TIM), 40 g 3-O-methylglucose (3OMG; a nonmetabolized substrate of SGLT1), or 60 mg sucralose was consumed 15 min before a (13)C-octanoic acid-labeled mashed potato meal. Blood glucose, plasma total GLP-1 and GIP, serum insulin, and gastric emptying were determined. Both glucose and 3OMG stimulated GLP-1 and GIP release in advance of the meal (each P < 0.05), whereas TIM and sucralose did not. The overall postprandial GLP-1 response was greater after glucose, 3OMG, and TIM than after sucralose (P < 0.05), albeit later after TIM than the other preloads. The blood glucose and insulin responses in the first 30 min after the meal were greatest after glucose (each P < 0.05). Gastric emptying was slower after both 3OMG and TIM than after sucralose (each P < 0.05). In healthy humans, SGLT1 substrates stimulate GLP-1 and GIP and slow gastric emptying, regardless of whether they are metabolized, whereas the artificial sweetener sucralose does not. Poorly absorbed sweet tastants (TIM), which probably expose a greater length of gut to nutrients, result in delayed GLP-1 secretion but not in delayed GIP release. These observations have the potential to optimize the use of preloads for glycemic control. This trial was registered at www.actr.org.au as ACTRN12611000775910.

Medicinal herbs in Iranian traditional medicine for learning and ...

African Journals Online (AJOL)

Conclusion: Most of the studies on TIM plants were designed in animal models and a few herbs were evaluated in clinical trials on AD. Also, for some of the herbal medicine used in TIM, there are no or not enough studies to confirm their effectiveness on memory and learning. Therefore, further experimental and clinical ...

Performance evaluation of indigenous thermal ionization mass spectrometer for determination of 235U/238U atom ratios

International Nuclear Information System (INIS)

Alamelu, D.; Parab, A.R.; Sasi Bhushan, K.; Shah, Raju V.; Jagdish Kumar, S.; Rao, Radhika M.; Aggarwal, S.K.; Bhatia, R.K.; Yadav, V.K.; Sharma, Madhavi P.; Tulsyan, Puneet; Chavda, Pradip; Sriniwasan, P.

2014-07-01

A magnetic sector based Thermal Ionization Mass Spectrometer (TIMS) designed and developed at Technical Physics Division, B.A.R.C., was evaluated for its performance for the determination of 235 U/ 238 U atom ratios in uranium samples. This consisted of evaluating the precision and accuracy on the 235 U/ 238 U atom ratios in various isotopic reference materials as well as indigenously generated uranium samples. The results obtained by the indigenous TIMS were also compared with those obtained using a commercially available TIMS system. The internal and external precision were found to be around 0.1% for determining 235 U/ 238 U atom ratios close to those of natural uranium ( i.e. 0.00730). (author)

PENGARUH IKLIM ORGANISASI TERHADAP KINERJA KARYAWAN LEVEL PELAKSANA DI DIVISI OPERASI PT. PUSRI PALEMBANG

Directory of Open Access Journals (Sweden)

Kiki Cahaya Setiawan

2016-05-01

Full Text Available This study aims to determine influence of organizational climate on the performance of operational-level employees in the Operations Division of PT. Pusri Palembang. Operational-level employees in doing their jobs, will interact with various conditions of working environment. Working environment in the Operations Division PT. Pusri Palembang will be perceived by employees in operational-level as organizational climate. With sampling technique of proportional random sampling and using path analysis to analyse the data. The sample of this research covers 250 operational-level employees. Conclude that there was significant influence on the performance of organizational climate  of operational-level employees in the operations division of PT. Pusri Palembang. Based on  the findings in this study, it is necessary to create a pleasant organizational climate for Operational-level employees.if this dimension can be created  in companies that can maintain and improve the performance of operational -level employees.

Thermal ionisation mass spectrometry: recent developments and future prospects

International Nuclear Information System (INIS)

Aggarwal, S.K.

1996-01-01

This paper presents the current state of art of thermal ionization mass spectrometry (TIMS) instrumentation and highlights some of the recent applications of TIMS in geological, biological and nuclear sciences with special emphasis on some of the recent work undertaken in the area of nuclear science and technology. A few examples from the published literature are also discussed here

Characterization of the heat transfer properties of thermal interface materials

Science.gov (United States)

Fullem, Travis Z.

Physicists have studied the thermal conductivity of solids for decades. As a result of these efforts, thermal conduction in crystalline solids is well understood; there are detailed theories describing thermal conduction due to electrons and phonons. Phonon scattering and transmission at solid/solid interfaces, particularly above cryogenic temperatures, is not well understood and more work is needed in this area. The desire to solve engineering problems which require good thermal contact between mating surfaces has provided enhanced motivation for furthering the state of the art on this topic. Effective thermal management is an important design consideration in microelectronic systems. A common technique for removing excess heat from an electronic device is to attach a heatsink to the device; it is desirable to minimize the thermal resistance between the device and the heatsink. This can be accomplished by placing a thermal interface material (TIM) between the two surfaces. Due to the ever-increasing power densities found in electronic components, there is a desire to design better TIMs, which necessitates the ability to characterize TIM bondlines and to better understand the physics of heat conduction through TIM bondlines. A micro Fourier apparatus which employs Pt thin film thermometers of our design has been built and is capable of precisely quantifying the thermal resistance of thermal interface materials. In the present work several types of commercially available TIMs have been studied using this apparatus, including: greases, filled epoxies, and thermally conductive pads. In the case of filled epoxies, bondlines of various thicknesses, ranging from thirty microns to several hundred microns, have been measured. The microstructure of these bondlines has been investigated using optical microscopy and acoustic microscopy. Measured values of thermal conductivity are considered in terms of microstructural features such as percolation networks and filler particle

Improved method for Hf separation from silicate rocks for isotopic analysis using Ln-spec resin column

International Nuclear Information System (INIS)

Shinjo, Ryuichi; Ginoza, Yuko; Meshesha, Daniel

2010-01-01

An improved chemical separation method for Hf isotope ratio measurement using both the thermal ionization mass spectrometer (TIMS) and the multiple collector-inductively coupled plasma-mass spectrometer (MC-ICP-MS) is presented in this paper. In the first column (2.5-ml Eichrom Ln-spec resin), Hf cut was collected with 2M HCl-0.2M HF after washing the major elements, HREE, Ti, Nb, and Zr. For further Hf purification, the second column (1-ml Ln-spec resin) chemistry was conducted in a manner similar to that of the first column. The first column is designed for treatment with a 0.5-g silicate rock sample for TIMS analysis. Thus, because the Hf amount required for MC-ICP-MS analysis is much lesser than that required for TIMS analysis, the column chemistry for MC-ICP-MS analysis can be scaled down, depending on the amount of digested sample. Although there is a need to improve the TIMS technique, the TIMS Hf data obtained for geological reference rocks and Ethiopian flood basalts after the application of the proposed separation methods are consistent, within analytical error, with the previously reported data obtained using the MC-ICP-MS. The advantages of the proposed method include a reduction in the amount of reagents used (hence, a consequent reduction in the blank contribution), reduction in the time required, and a simplified preparation requiring a fewer number of acids. (author)

Physics Conference TIM-15-16

CERN Document Server

2016-01-01

The Conference is organized by the West University of Timisoara, Faculty of Physics. The scientific program of the conference will include invited lectures, oral and poster presentations, as well as discussions on various topics of present interest, such as, but not limited to condensed matter physics and applications, theoretical and computational physics, and applied physics.

Thieme Textbook Internal Medicine - TIM

International Nuclear Information System (INIS)

Flasnoecker, M.

1999-01-01

The textbook and reference work covers the entire field of internal medicine arranged in 15 chapters, each covering a particular branch of internal medicine. This subject arrangement corresponds to the subject clusters of the regime of post-graduate education. Every branch, i. e. every chapter, has its own responsible editor. This selection of editors and authors,- all in all 180 experts in general and clinical practice -, guarantees a maximum of competence and compliance with the frontiers of research and clinical experience. (orig./CB) [de

Interim Results from a Study of the Impacts of Tin (II) Based Mercury Treatment in a Small Stream Ecosystem: Tims Branch, Savannah River Site

Energy Technology Data Exchange (ETDEWEB)

Looney, Brian [Savannah River National Laboratory (SRNL); BryanJr., Larry [Savannah River Ecology Laboratory; Mathews, Teresa J [ORNL; Peterson, Mark J [ORNL; Roy, W Kelly [ORNL; Jett, Robert T [ORNL; Smith, John G [ORNL

2012-03-01

A research team is assessing the impacts of an innovative mercury treatment system in Tims Branch, a small southeastern stream. The treatment system, installed in 2007, reduces and removes inorganic mercury from water using tin(II) (stannous) chloride addition followed by air stripping. The system results in discharge of inorganic tin to the ecosystem. This screening study is based on historical information combined with measurements of contaminant concentrations in water, fish, sediment, biofilms and invertebrates. Initial mercury data indicate that first few years of mercury treatment resulted in a significant decrease in mercury concentration in an upper trophic level fish, redfin pickerel, at all sampling locations in the impacted reach. For example, the whole body mercury concentration in redfin pickerel collected from the most impacted pond decreased approximately 72% between 2006 (pre-treatment) and 2010 (post-treatment). Over this same period, mercury concentrations in the fillet of redfin pickerel in this pond were estimated to have decreased from approximately 1.45 {micro}g/g (wet weight basis) to 0.45 {micro}g/g - a decrease from 4.8x to 1.5x the current EPA guideline concentration for mercury in fillet (0.3 {micro}g/g). Thermodynamic modeling, scanning electron microscopy, and other sampling data for tin suggest that particulate tin (IV) oxides are a significant geochemical species entering the ecosystem with elevated levels of tin measured in surficial sediments and biofilms. Detectable increases in tin in sediments and biofilms extended approximately 3km from the discharge location. Tin oxides are recalcitrant solids that are relatively non-toxic and resistant to dissolution. Work continues to develop and validate methods to analyze total tin in the collected biota samples. In general, the interim results of this screening study suggest that the treatment process has performed as predicted and that the concentration of mercury in upper trophic level

Otonomi Moral Keagamaan Mahasiswa

Directory of Open Access Journals (Sweden)

Muhammad Idrus

2014-07-01

Full Text Available Secara umum tujuan penelitian ini adalah untuk memahami dan menganalisis fenomena otonomi moral keagamaan mahasiswa Fakultas Tarbiyah, yang diharapkan dapat menjadi balikan bagi perumusan model ideal pendidikan moral yang sesuai dengan kaidah agama Islam. Penelitian ini menggunakan pendekatan kualitatif dengan desain studi kasus terpancang {embedded case study, dengan mengambil latar Fakultas Tarbiyah UII. Model ini diharapkan dapat memberikan gambaran makna mendalam tentang perilaku keseharian mahasiswa-mahasiswi sesuai fokus penelitian yang diajukan. Pengamatan, wawancara, rekaman audio dan rekaman visual digunakan dalam proses pengumpulan data yang melibatkan mahasiswa dan dosen. Analisis domain, taksonomik, komponensial dan tema digunakan dalam mereduksi dan mengklasifikasi data yang diperoleh u ntuk mendeskripsikan kenyataan empiris. Hasil penelitian menunjukkan perilaku kegamaan yang ditampilkan para informan cenderung tidak memiliki otonomi moral keagamaan yang baik, atau masih dalam tahapan heteronomi. Hal tersebut ditunjukkan adanya pelbagai harapan atas pelaksanaan perintah yang dilakukan, ataupun penghindaran larangan. Kedua, dalam memeluk agama tampaknya secara umum informan masih bersifat pewarisan dari para orang tuanya. Ketiga, dalam upayanya untuk membangkitkan otonomi moral keagamaan mahasiswa, dosen melakukan dengan cara himbauan, nasehat, ataupun bimbingan yang diberikan pada waktu-waktu tertentu dan tidak terjadual dalam kegiatan tatap muka di kelas. Berdasarkan pada hasil penelitian diajukan beberapa saran, yaitu: Pertama, adanya pengakuan informan bahwa agama yang dianutnya merupakan agama warisan orang tua mereka, dapat dijadikan sebagai fokus pada penelitian berikut. Kedua, dalam penelitian ini kajian otonomi moral keagamaan dilihat dari sudut pandang agama Islam. Tentunya melihat variasi agama yang ada di Indonesia, sudut pandang penelitian lanjutan dapat dilakukan melalui "kaca mata" agama-agama yang berbeda.

PEMANFAATAN TELUR AYAM SEBAGAI PABRIK BIOLOGIS (KAJIAN PUSTAKA

Directory of Open Access Journals (Sweden)

I WAYAN TEGUH WIBAWAN

2012-09-01

Full Text Available ABSTRAK Penelitian tentang pemanfaatan telur sebagai pabrik biologis dilakukan sangat komprehensif di beberapa institusi perguruan tinggi di Inonesia, yakni Fakultas Kedokteran Hewan (FKH Institut Pertanian Bogor (IPB, FKH Universitas Gadjah Mada (UGM, FKH Universitas Udayana (UNUD, FKH Universitas Syahkuala (Unsyiah, Fakultas Kedokteran Gigi Universitas Indonesia. Jejaring penelitian dibangun dengan baik dan telah menghasilkan beberapa produk, antara lain: telur berkhasiat flu burung H5N1, telur Anti Tetanus Serum, Telur Anti Diare, Telur anti Plaque dan Telur Anti White Spot Syndrome Virus pada udang. Secara ilmiah khasiat IgY spesifik dalam kuning telur sebagai senyawa therapeutic telah diuji dan tinggal memerlukan sentuhan akhir tersendiri untuk dapat disajikan sebagai produk komersial. Peran industri yang relevan sangat dibutuhkan dalam mewujudkan hal ini. THE USE OF EGG AS A BIOLOGICAL PRODUCER FOR SPESIFIC ANTIBODIES ABSTRACTS The use of egg as a biological producer for specific antibodies were done intensively among well known universities in Indonesia, such as Faculty of Veterinary Medicine (FVM of FVM of IPB, FVM of UGM, FVM of UDAYANA and FVM of UNSYIAH as well as Faculty of Dental Medicine Indonesia University. The collaboration and research networking among those institutions run as expected and succeed to produce some important products such as eggs containing IgY anti avian flu as well as anti tetanus, anti diarrhea, anti plaques and eggs anti WSSV in shrimp. The potency of specific IgY as immunotherapeutic substances had been studied and need the commercial touch from the respective industries until this products in market available.

Differences in regional muscle distribution in football players

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Nešić N.

2012-01-01

Full Text Available The objective of this study was to determine whether there are differences in regional distribution of muscle mass between a dominant and a non-dominant side and between an injured and an uninjured side. The study involved 31 participant with the following characteristics: aged 22±5 years, body height (TV 184±13 cm, body weight (TM 80±13 kg, average body fat weight (BF 14,35 kg, body mass index (BMI 24,8±4, and average percentage of body fat 15,5% (PBF. Of the total number of participants, 16 players (TIM 1 are playing football in the Croatian Second Division and 15 players (TIM 2 are playing in the Second County League. Measurements of muscle mass were conducted in two ways - measurements with bioelectrical impedance (BIA and anthropometric measurements. The girth was measured at eight different places - left and right forearm and upper arm, left and right leg and thigh. Additionally, the skin folds were measured on each side of the body: the skin fold on posterior side of the upper arm (triceps, on lateral side of the forearm, on anterior side of the thigh and on medial side of the lower leg. Data on muscle mass of individual segments of the left and right sides of the body were obtained with GAIA 359 device. The results of the statistical test showed a statistically significant difference among all groups except the differences between the dominant and non-dominant hand in TIM-1. In TIM-2, the average value of difference in muscle mass for arms is 0,012 kg and for legs 0,268 kg, both values in favor of the dominant hand. In TIM-1, the average value of difference in muscle mass is 0,087 kg in favor of non-dominant leg; the reason could be in a greater number of injuries on the dominant side. When it comes to injuries, both teams have seven players who suffered different injuries, of that number all the injuries were on the dominant leg in the TIM-1, whereas only two injuries were on the dominant side in TIM-2. The difference between the

Training implementation matrix. Spent Nuclear Fuel Project (SNFP)

International Nuclear Information System (INIS)

EATON, G.L.

2000-01-01

This Training Implementation Matrix (TIM) describes how the Spent Nuclear Fuel Project (SNFP) implements the requirements of DOE Order 5480.20A, Personnel Selection, Qualification, and Training Requirements for Reactor and Non-Reactor Nuclear Facilities. The TIM defines the application of the selection, qualification, and training requirements in DOE Order 5480.20A at the SNFP. The TIM also describes the organization, planning, and administration of the SNFP training and qualification program(s) for which DOE Order 5480.20A applies. Also included is suitable justification for exceptions taken to any requirements contained in DOE Order 5480.20A. The goal of the SNFP training and qualification program is to ensure employees are capable of performing their jobs safely and efficiently

Skills of Chemistry Pupils during the Period of Curricular Reform

OpenAIRE

Bayerová, Anna

2015-01-01

Univerzita Karlova v Praze, Přírodovědecká fakulta Katedra učitelství a didaktiky chemie Charles University in Prague, Faculty of Science Department of Teaching and Didactics of Chemistry Doktorský studijní program: Vzdělávání v chemii Ph.D. study program: Education in Chemistry Autoreferát disertační práce Summary of the Ph.D. Thesis Mgr. Anna Bayerová Dovednosti žáků v chemii v období kurikulární reformy Skills of Chemistry Pupils during the Period of Curricular Reform Školitel/Supervisor: ...

Workplace Spirituality Tenaga Kependidikan Universitas Brawijaya (Studi Pada Fakultas Ilmu Pengetahuan Alam Dan Matematika Serta Fakultas Ilmu Sosial dan Ilmu Politik

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Sutan Rachman WHS

2014-12-01

Full Text Available Konsep pengembangan manusia secara menyeluruh merupakan solusi atas perubahan fenomena sosial saat ini yang menyebabkan kehidupan seseorang tidak menyatu karena lingkungan pekerjaan atau tempat kerja hanya menjadi tempat untuk mencari hal-hal profan (duniawi dan tidak mempunyai ruang untuk sesuatu yang sakral atau suci. Akibat dari adanya pemisahan ini, seseorang lebih terfokus hidupnya untuk menggeluti dunia karir tanpa memperhatikan kehidupan batinnya. Fenomena tersebut menumbuhkan kesadaran untuk menghubungkan aspek spiritualitas individu dengan pengelolaan pekerjaan  atau lingkungan kerja, melalui konsep workplace spirituality,. Dalam studi akademis, workplace spirituality merupakan bidang yang masih baru dan masih terus dikembangkan, namun sebagian besar studi masih dilakukan di Amerika Serikat dan Kanada, dan sangat sedikit sekali yang dilakukan di luar kedua negara tersebut. Berdasarkan hal itu, penelitian ini bermaksud untuk memperkaya topik workplace spirituality dari sudut pandang administrator publik di Indonesia melalui pendekatan fenomenologi, dengan menggunakan metode kualitatif, penelitian ini menghasilkan dua sudut pandang terkait workplace spirituality, pertama adalah sudut pandang agama dan yang kedua adalah sudut pandang intrinsik  -  alamiah, kedua sudut pandang tersebut sama – sama bertujan untuk memberikan makna dalam bentuk ekspresi positif dalam lingkungan kerja. Penelitian lebih jauh juga dibutuhkan untuk memperkokoh konsep ini, baik melalui metode kualitatif maupun kuantitatif.Kata kunci: Agama, Perilaku, Spiritual, Tuhan, Workplace Spirituality,

Thermal performance of a phase change material on a nickel-plated surface

International Nuclear Information System (INIS)

Nurmawati, M.H.; Siow, K.S.; Rasiah, I.J.

2004-01-01

Thermal control becomes increasingly vital with IC chips becoming faster and smaller. The need to keep chips within acceptable operating temperatures is a growing challenge. Thermal interface materials (TIM) form the interfaces that improve heat transfer from the heat-generating chip to the heat dissipating thermal solution. One of the most commonly used materials in today's electronics industry is phase change material (PCM). Typically, the heat spreader is a nickel-plated copper surface. The compatibility of the PCM to this surface is crucial to the performance of the TIM. In this paper, we report on the performance of this interface. To that end, an instrument to suitably measure critical parameters, like the apparent and contact thermal resistance of the TIM, is developed according to the ASTM D5470 and calibrated. A brief theory of TIM is described and the properties of the PCM were investigated using the instrument. Thermal resistance measurements were made to investigate the effects of physical parameters like pressure, temperature and supplied power on the thermal performance of the material on nickel-plated surface. Conclusions were drawn on the effectiveness of the interface and their application in IC packages

Graphene-enhanced thermal interface materials for heat removal from photovoltaic solar cells

Science.gov (United States)

Saadah, M.; Gamalath, D.; Hernandez, E.; Balandin, A. A.

2016-09-01

The increase in the temperature of photovoltaic (PV) solar cells affects negatively their power conversion efficiency and decreases their lifetime. The negative effects are particularly pronounced in concentrator solar cells. Therefore, it is crucial to limit the PV cell temperature by effectively removing the excess heat. Conventional thermal phase change materials (PCMs) and thermal interface materials (TIMs) do not possess the thermal conductivity values sufficient for thermal management of the next generation of PV cells. In this paper, we report the results of investigation of the increased efficiency of PV cells with the use of graphene-enhanced TIMs. Graphene reveals the highest values of the intrinsic thermal conductivity. It was also shown that the thermal conductivity of composites can be increased via utilization of graphene fillers. We prepared TIMs with up to 6% of graphene designed specifically for PV cell application. The solar cells were tested using the solar simulation module. It was found that the drop in the output voltage of the solar panel under two-sun concentrated illumination can be reduced from 19% to 6% when grapheneenhanced TIMs are used. The proposed method can recover up to 75% of the power loss in solar cells.

IMPLEMENTASI POPULATION RESIZING ON FITNESS IMPROVEMENT GENETIC ALGORITHM (PROFIGA UNTUK OPTIMASI RUTE KUNJUNGAN PROMOSI UNIVERSITAS MURIA KUDUS BERBASIS ANDROID DAN GOOGLE MAPS API

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Tri Listyorini

2016-04-01

Full Text Available Tim Promosi Universitas Muria Kudus (UMK melakukan kunjungan promosi ke sekolah menengah atas pada setiap tahun. Kunjungan tersebut dilakukan ke sekolah-sekolah menengah atas di wilayah Kudus, Jepara, Pati, Demak, Rembang dan Purwodadi. Untuk memudahkan kunjungan, setiap kunjungan dibatasi sekitar 15 (lima belas sekolah. Namun pada saat melakukan kunjungan, tim tersebut mengalami kesulitan dalam menentukan rute kunjungan sekolah. Hal ini dikarenakan jarak sekolah yang dikunjungi cukup jauh atau memiliki rute yang rumit sehingga menyebabkan waktu kunjungan yang molor dan biaya pengeluaran bahan bakar yang cukup boros. Untuk menyelesaikan masalah tersebut, dikembangkan suatu aplikasi menggunakan metode heuristik algoritma genetika dengan dinamisasi ukuran populasi atau Population Resizing on Fitness Improvement Genetic Algorithm (PRoFIGA. Aplikasi dikembangkan dengan basis android digunakan untuk memudahkan mencari rute kunjungan terpendek bagi tim promosi UMK sehingga waktu kunjungan menjadi efektif dan efisien. Hasil dari penelitian adalah aplikasi berbasis android untuk penentuan rute kunjungan sekolah terpendek menggunakan metode heuristik yang efisien dan efektif yang dikombinasikan dengan Google Maps Application Programming Interface (API untuk display rute kunjungan sehingga lebih memudahkan bagi tim promosi UMK. Kata kunci: optimasi rute kunjungan, algoritma fuzzy evolusi, optimasi rute android.

Microencapsulation increases survival of the probiotic Lactobacillus plantarum IS-10506, but not Enterococcus faecium IS-27526 in a dynamic, computer-controlled in vitro model of the upper gastrointestinal tract.

Science.gov (United States)

Surono, I; Verhoeven, J; Verbruggen, S; Venema, K

2018-02-23

To test the effect of microencapsulation on the survival of two probiotic strains isolated from Dadih, Indonesian fermented buffalo milk, in a dynamic, computer-controlled in vitro model of the upper gastrointestinal (GI) tract (TIM-1), simulating human adults. Free or microencapsulated probiotics, Lactobacillus plantarum IS-10506 or Enterococcus faecium IS-27526, resuspended in milk were studied for survival in the complete TIM-1 system (stomach + small intestine) or in the gastric compartment of TIM-1 only. Hourly samples collected after the ileal-caecal valve or after the pylorus were plated on MRS agar (for Lactobacillus) or S&B agar (for Enterococcus). Survival of the free cells after transit through the complete TIM-1 system was on average for the E. faecium and L. plantarum 15·0 and 18·5% respectively. Survival of the microencapsulated E. faecium and L. plantarum was 15·7 and 84·5% respectively. The free cells were further assessed in only the gastric compartment of TIM-1. E. faecium and L. plantarum showed an average survival of 39 and 32%, respectively, after gastric passage. There is similar sensitivity to gastric acid as well as survival after complete upper GI tract transit of free cells, but microencapsulation only protected L. plantarum. Survival of microencapsulated L. plantarum IS-10506 is increased compared to free cells in a validated in vitro model of the upper GI tract. It increases its use as an ingredient of functional foods. © 2018 The Society for Applied Microbiology.

Thermal structure and dynamics of the Martian upper atmosphere at solar minimum from global circulation model simulations

Directory of Open Access Journals (Sweden)

T. Moffat-Griffin

2007-11-01

Full Text Available Simulations of the Martian upper atmosphere have been produced from a self-consistent three-dimensional numerical model of the Martian thermosphere and ionosphere, called MarTIM. It covers an altitude range of 60 km to the upper thermosphere, usually at least 250 km altitude. A radiation scheme is included that allows the main sources of energy input, EUV/UV and IR absorption by CO2 and CO, to be calculated. CO2, N2 and O are treated as the major gases in MarTIM, and are mutually diffused (though neutral chemistry is ignored. The densities of other species (the minor gases, CO, Ar, O2 and NO, are based on diffusive equilibrium above the turbopause. The ionosphere is calculated from a simple photoionisation and charge exchange routine though in this paper we will only consider the thermal and dynamic structure of the neutral atmosphere at solar minimum conditions. The semi-diurnal (2,2 migrating tide, introduced at MarTIM's lower boundary, affects the dynamics up to 130 km. The Mars Climate Database (Lewis et al., 2001 can be used as a lower boundary in MarTIM. The effect of this is to increase wind speeds in the thermosphere and to produce small-scale structures throughout the thermosphere. Temperature profiles are in good agreement with Pathfinder results. Wind velocities are slightly lower compared to analysis of MGS accelerometer data (Withers, 2003. The novel step-by-step approach of adding in new features to MarTIM has resulted in further understanding of the drivers of the Martian thermosphere.

Reviews: New Literature on Law and Political Institutions in Indonesia

OpenAIRE

Prasad, Karolina

2012-01-01

1) Butt, Simon, and Tim Lindsey (2012): The Constitution of Indonesia: A Contextual Analysis. Oxford: Hart Publishing (Constitutional Systems of the World Series). ISBN-13: 978-1849460187 2) Kimura, Ehito (2012): Political Change and Territoriality in Indonesia: Provincial Proliferation. London: Routledge (Routledge Contemporary Southeast Asia Series). ISBN 9781136301810. 3) Lindsey, Tim (2012): Islam, Law and the State in Southeast Asia: Volume I: Indonesia London: Tauris. (Islam...

IMPLEMENTASI POPULATION RESIZING ON FITNESS IMPROVEMENT GENETIC ALGORITHM (PROFIGA) UNTUK OPTIMASI RUTE KUNJUNGAN PROMOSI UNIVERSITAS MURIA KUDUS BERBASIS ANDROID DAN GOOGLE MAPS API

OpenAIRE

Tri Listyorini; Syafiul Muzid

2016-01-01

Tim Promosi Universitas Muria Kudus (UMK) melakukan kunjungan promosi ke sekolah menengah atas pada setiap tahun. Kunjungan tersebut dilakukan ke sekolah-sekolah menengah atas di wilayah Kudus, Jepara, Pati, Demak, Rembang dan Purwodadi. Untuk memudahkan kunjungan, setiap kunjungan dibatasi sekitar 15 (lima belas) sekolah. Namun pada saat melakukan kunjungan, tim tersebut mengalami kesulitan dalam menentukan rute kunjungan sekolah. Hal ini dikarenakan jarak sekolah yang dikunjungi cukup jauh ...

Metallized compliant 3D microstructures for dry contact thermal conductance enhancement

Science.gov (United States)

Cui, Jin; Wang, Jicheng; Zhong, Yang; Pan, Liang; Weibel, Justin A.

2018-05-01

Microstructured three-dimensional (3D) materials can be engineered to enable new capabilities for various engineering applications; however, microfabrication of large 3D structures is typically expensive due to the conventional top-down fabrication scheme. Herein we demonstrated the use of projection micro-stereolithography and electrodeposition as cost-effective and high-throughput methods to fabricate compliant 3D microstructures as a thermal interface material (TIM). This novel TIM structure consists of an array of metallized micro-springs designed to enhance the dry contact thermal conductance between nonflat surfaces under low interface pressures (10s-100s kPa). Mechanical compliance and thermal resistance measurements confirm that this dry contact TIM can achieve conformal contact between mating surfaces with a nonflatness of approximately 5 µm under low interface pressures.

Can We Defend the Defense Supply Chain Lessons Learned from Industry Leaders in Supply Chain Management

Science.gov (United States)

2018-03-01

Simpson, “Tim Cook: The ‘Cool Customer ’ Behind Apple’s Supply Chain Success,” Supply Management , January 18, 2016, https://www.cips.org/supply... management /analysis/2016/february/tim- cook-the-cool- customer -behind-apples-supply-chain-success/. 13 Kif Leswing, “Apples ‘Shreds” Old iPhones to Prevent...chain, including products, services, information, finances, demand, relationships , and risks. In a more complete definition, supply chain management

Efficacy and Tolerability of Fixed-Combination Brinzolamide/Timolol in Latin American Patients with Open-Angle Glaucoma or Ocular Hypertension Previously on Brimonidine/Timolol Fixed Combination

OpenAIRE

Alezzandrini, Arturo; Hubatsch, Douglas; Alfaro, Rene

2014-01-01

Introduction Fixed-combination glaucoma medications are commonly used to achieve target intraocular pressure (IOP) reduction in patients uncontrolled with monotherapy; however, ocular discomfort associated with eye drops can decrease adherence. This study assessed the efficacy and tolerability of twice-daily fixed-combination brinzolamide 1%/timolol 0.5% (BRINZ/TIM-FC) in Latin American patients transitioned from fixed-combination brimonidine 0.2%/timolol 0.5% (BRIM/TIM-FC) because of insuffi...

How Much Will Be Enough? Assessing Changing Defense Strategies Implications for Army Resource Requirements

Science.gov (United States)

2014-01-01

force management and modernization 59 See, for example, Tim Bonds, Glenn A. Kent, Colin Lampard, Randall Bowdish, John Birkler, Monti D. Callero... Tim , Glenn A. Kent, Colin Lampard, Randall Bowdish, John Birkler, Monti D. Callero, and James Chiesa, A Tool for Evaluating Force Modernization...Force Takes Shape at Fort Bliss ,” Army Magazine, Vol. 57, No. 3, March 2007. Harvey, Francis J., and Peter J. Schoomaker, 2007 Army Posture

Thermal structure and dynamics of the Martian upper atmosphere at solar minimum from global circulation model simulations

Directory of Open Access Journals (Sweden)

T. Moffat-Griffin

2007-11-01

Full Text Available Simulations of the Martian upper atmosphere have been produced from a self-consistent three-dimensional numerical model of the Martian thermosphere and ionosphere, called MarTIM. It covers an altitude range of 60 km to the upper thermosphere, usually at least 250 km altitude. A radiation scheme is included that allows the main sources of energy input, EUV/UV and IR absorption by CO₂ and CO, to be calculated. CO₂, N₂ and O are treated as the major gases in MarTIM, and are mutually diffused (though neutral chemistry is ignored. The densities of other species (the minor gases, CO, Ar, O₂ and NO, are based on diffusive equilibrium above the turbopause. The ionosphere is calculated from a simple photoionisation and charge exchange routine though in this paper we will only consider the thermal and dynamic structure of the neutral atmosphere at solar minimum conditions. The semi-diurnal (2,2 migrating tide, introduced at MarTIM's lower boundary, affects the dynamics up to 130 km. The Mars Climate Database (Lewis et al., 2001 can be used as a lower boundary in MarTIM. The effect of this is to increase wind speeds in the thermosphere and to produce small-scale structures throughout the thermosphere. Temperature profiles are in good agreement with Pathfinder results. Wind velocities are slightly lower compared to analysis of MGS accelerometer data (Withers, 2003. The novel step-by-step approach of adding in new features to MarTIM has resulted in further understanding of the drivers of the Martian thermosphere.

Performance of laser ablation. Quadrupole-based ICP-MS coupling for the analysis of single micrometric uranium particles

International Nuclear Information System (INIS)

Fabien Pointurier; Amelie Hubert; Anne-Claire Pottin

2013-01-01

In this paper we describe the application of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) coupling to particle analysis, i.e., the determination of the isotopic composition of micrometric uranium particles. The performances of this analysis technique are compared with those of the two reference particle analysis techniques: secondary ion mass spectrometry (SIMS) and fission track-thermo-ionization mass spectrometry (FT-TIMS), based on the measurement of the isotopic ratios of 235 U/ 238 U in particles present in an inter-comparison particulate sample. The agreement of the results obtained using LA-ICP-MS with target values and with the results obtained using FT-TIMS and SIMS was good. Accuracy was equivalent to that of the other two techniques (±3 % deviation). However, relative experimental uncertainties present with LA-ICP-MS (7 %) were higher than those present with FT-TIMS (4.5 %) and SIMS (3 %). Furthermore, measurement yield of LA-ICP-MS coupling was close to that obtained with the same quadrupole ICP-MS for the measurement of a liquid sample (∼10 -4 ), but lower than that obtained with FT-TIMS and SIMS, respectively, by a factor of 10 and 20, although the particles analyzed using LA-ICP-MS were most likely smaller (diameter ∼0.6 μm, containing 4-7 fg of 235 U). Nevertheless, thanks to the brevity of the signals obtained, the detection capacity for low isotopic concentrations by LA-ICP-MS coupling is equivalent to that of FT-TIMS, although it remains well below that of SIMS (x 15). However, with more sensitive double focusing ICP-MS, performances equivalent to those achieved using SIMS could be obtained. (author)

Pengaruh Gaya Kepemimpinan Kepala Ruangan Terhadap Kinerja Perawat Pelaksana di Rumah Sakit Provinsi Sumatera Utara

OpenAIRE

Zebua, Oktoberius

2014-01-01

Hospital as one of the health care facility has strategic role in their effort to accelerate the improvement of health of Indonesian. The nursing profession is one component of which is regarded as the key to the success of service delivery in the hospital. Successful leader is a leader who adjusts their leadership style to the organization he leads, the ability to set high goals to be achieved, the willingness and ability to take responsibility for the task, relevant education, experience, v...

IMPLEMENTASI SUBVERSION DAN REDMINE PROJECT MANAGEMENT DALAM PERANCANGAN TOKO KUE ONLINE

Directory of Open Access Journals (Sweden)

Xanty Adhi Parandani

2016-04-01

Full Text Available Belanja online telah menjadi gaya hidup konsumen saat ini. Kemudahan, mobilitas dan fleksibilitas menjadi daya tarik dari komponen e-commerce ini. Bagi penjual, metode penjualan via web merupakan salah satu metode yang sangat efisien, ekonomis dan efektif untuk meningkatkan omzet penjualan. Sebagai contoh kasus untuk penerapan konsep manajemen proyek, dibuat sebuahpurwarupa toko kue yang dirancang untuk sistem penjualan berbasis web (online. Purwarupa ini dibangun secara tim, dimana komponen dari situs ini dibuat secara terpisah- pisah oleh masing-masing anggota tim. Dengan memanfaatkan fasilitas Subversion, partisi komponen sistem disatukan menjadi sebuah sistem yang utuh. Sebagai sebuah proyek sistem informasi yang dibangun secara tim, dibuat sistem pengaturan proyek menggunakan sebuah aplikasi manajemen proyek, Redmine Project Management. Redmine merupakan proyek manajemen berbasis web yang dibangun dengan bahasa Ruby diatas Framework Rail. Pembangunan web secara berkelompok dengan tugas individu mandiri akan sangat bermanfaat dalam mengembangkan kreativitas setiap individu, sehingga situs yang dihasilkan akan lebih unik, menarik dan easy fault tracing, karena mudahnya melacak letak dan penyebab kesalahan. Dari hasil kolaborasi menggunakan fasilitas Redmine dan Subversion, diperoleh sebuah situs toko kue online yang merupakan represntasi dari beragam gagasan anggota tim, namun bisa diintegrasikan dan berfungsi dengan baik, selayaknya situs yang dibuat secara individu. Kata kunci: e-commerce, Tokokueku, Subversion, Redmine project management, ruby, framework rail.

Technical infrastructure monitoring from the CCC

CERN Document Server

Stowisek, J; Suwalska, A; CERN. Geneva. TS Department

2005-01-01

In the summer of 2005, the Technical Infrastructure Monitoring (TIM) system will replace the Technical Data Server (TDS) as the monitoring system of CERN’s technical services. Whereas the TDS was designed for the LEP, TIM will have to cope with the much more extensive monitoring needs of the LHC era. To cater for this, the new system has been built on industry-standard hardware and software components, using Java 2 Enterprise Edition (J2EE) technology to create a highly available, reliable, scalable and flexible control system. A first version of TIM providing the essential functionality will be deployed in the MCR in June 2005. Additional functionality and more sophisticated tools for system maintenance will be ready before the start-up of the LHC in 2007, when CERN’s technical infrastructure will be monitored from the future CERN Control Centre.

ICP magnetic sector multiple collector mass spectrometry and the precise measurement of isotopic compositions using nebulization of solutions and laser ablation of solids

International Nuclear Information System (INIS)

Halliday, A.N.; Lee, D-C.; Christensen, J.N.; Yi, W.; Hall, C.M.; Jones, C.E.; Teagle, D.A.H.; Freedman, P.A.

1996-01-01

Inductively-coupled plasma (ICP) sources offer considerable advantages over thermal sources because the high ionization efficiency facilitates measurements of relatively high sensitivity for elements such as Hf or Sn, which can be difficult to measure precisely with thermal ionization mass spectrometry (TIMS). The mass discrimination (bias) is larger than for TIMS, favours the heavier ions, and decreases in magnitude with increasing mass. However, in contrast to TIMS, this discrimination is largely independent of the chemical or physical properties of the element or the duration of the analysis. This has been demonstrated to high precision with a double focussing multiple collector magnetic sector mass spectrometer with an ICP source. The principle of this instrument is briefly described. The potential of the instrument for high precision isotopic measurements of a very broad range of elements, using solution aspiration or laser ablation, is indicated. 15 refs

Comparison of burnup methods for (Th,U)O2 fuel

International Nuclear Information System (INIS)

Green, L.W.; Cassidy, R.M.; Edwards, W.J.; Knight, C.H.

1983-01-01

Analysis methods based on thermal ionisation mass spectrometry (TIMS), high performance liquid chromatography (HPLC) and instrumental neutron activation (INA) were investigated. Fission products 139 La, 140 Ce, 142 Ce, 145+146 Nd and the sum of the major lanthanides (masses 139 to 152) were evaluated as fission monitors. A TIMS- 145+146 Nd method was selected as a reference method, and a HPLC- 139 La method showed good agreement and similar precision. Results obtained by INA- 142 Ce, HPLC-(139-152) and TIMS-1 48 Nd methods showed significant differences from those obtained by the above two, for various reasons. The weight and initial composition of the fuel was shown to give a sufficiently accurate estimate of the initial heavy element content; this combined with the HPLC- 139 La method yielded a fast, low-cost burnup method. (author)

Current Issues in Maritime Health

DEFF Research Database (Denmark)

Wagtmann, Maria Anne

2008-01-01

 In the early part of 2008, Maria Anne Wagtmann had the opportunity to interview the former president of the International Maritime Health Association, Dr. Tim Carter, in London about a number of current maritime health issues. In this interview, Dr. Tim Carter, who is cur­rently employed...... as the Chief Medical Advisor for the British government's Department for Transport, gives his personal - and thus non-official - opinions on these issues....

Real-Time Identification of Wheel Terrain Interaction Models for Enhanced Autonomous Vehicle Mobility

Science.gov (United States)

2014-04-24

tim at io n Er ro r ( cm ) 0 2 4 6 8 10 Color Statistics Angelova...Color_Statistics_Error) / Average_Slip_Error Position Estimation Error: Global Pose Po si tio n Es tim at io n Er ro r ( cm ) 0 2 4 6 8 10 12 Color...get some kind of clearance for releasing pose and odometry data) collected at the following sites – Taylor, Gascola, Somerset, Fort Bliss and

ANALISIS KUALITAS PELAYANAN PADA BAGIAN TATA USAHA BERDASARKAN TINGKAT KEPUASAN MAHASISWA

Directory of Open Access Journals (Sweden)

Muzakiyah Muzakiyah

2011-12-01

Full Text Available Kepuasan pelanggan merupakan hasil (outcome yang dirasakan atas penggunanya produk atau jasa, sama atau melebihi harapan yang diinginkan. Pelayanan di bagian Tata Usaha idealnya lebih bersahabat, cepat dan akurat. Ini berarti orientasi layanan di bagian Tata Usaha harus didasarkan pada kebutuhan mahasiswa. Dalam penelitian ini metode yang digunakan dengan menggunakan Pendekatan Lean ServPerf (Lean Service dan Service Performance. Service Performance digunakan untuk menganalisis tingkat instrumen kinerja pelayanan bagian Tata Usaha. Lean Service digunakan untuk menghilangkan waste aktivitas yang tidak bernilai tambah. Hasil dari penelitian ini, terdapat 14 atribut pelayanan yang perlu dilakukan perbaikan untuk meningkatkan kualitas pelayanan di bagian Tata Usaha Fakultas.

Pemberdayaan Masyarakat Melalui Community Development Program Posdaya (Pos Pemberdayaan Keluarga Pt. Holcim Indonesia Tbk Pabrik Cilacap

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Agus Triyono

2017-01-01

bergerak dalam produksi semen yang mempunyai kecenderungan memberikan polusi udara dan suara yang dapat merugikan masyarakat sekitar perusahaan. Dengan metode kualitatif penelitian ini bermaksud untuk mencari bagaimanakah implementasi strategi pengelolaan CSR dengan program Posdaya yang telah dilakukan oleh PT. Holcim Indonesia Tbk Cilacap Plant dalam rangka memberdayakan masyarakat yang berada disekitar perusahaan tersebut. Metode pengumpulan data berupa FGD dan dokumentasi yang selanjutnya akan diolah dengan analisis interaktif Miles dan Huberman. Sedangkan untuk validitas penelitian, peneliti menggunakan teknik triangulasi sumber. Hasil penelitian menunjukan bahwa PT Holcim berkonsentrasi pada pemberdayaan masyarakat berbasis 4 pilar, yaitu kesehatan, pendidikan, ekonomi dan lingkungan. Untuk tahapan dalam pelaksanaan Posdaya dilakukan dengan 2 tahapan, yakni analisa kebutuhan dan dilanjutkan sosialisasi kepada masyarakat yang akan menjadi subjek pelaksana Posdaya. Dalam melaksanakan kegiatan Posdaya tersebut dijalankan dengan kegiatan CSR, serta menjalin hubungan dengan komunitas, pemerintah dan LSM, berpusat pada community relation department. PT Holcim.

Implementasi Sistem Informasi Puskesmas Elektronik (SIMPUSTRONIK dan Hubungan Dengan Pelayanan Kesehatan Ibu dan Anak (KIA (Studi Perbandingan Implementasi di Puskesmas Sumberasih dan Puskesmas Paiton Kabupaten Probolinggo

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Sunar Wibowo

2015-08-01

Full Text Available Puskesmas sebagai penyedia sarana pelayanan kesehatan dituntut untuk memberikan pelayanan kesehatan yang cepat, tepat dan akurat. Oleh karena itu, merupakan suatu keharusan bahwa puskesmas memanfaatkan kemajuan informasi teknologi dalam memenuhi tuntutan pelayanan tersebut. Dengan pendekatan kuantitatif positivitik untuk menjelaskan hipotesa penelitian guna menjawab faktor implementasi yang mendukung dan kemanfaatan SIMPUSTRONIK. Survey yang dilakukan kepada bidan sebagai pelaksana SIMPUSTRONIK di Puskesmas Paiton dan Puskesmas Sumberasih Kabupaten Probolinggo menghasilkan 3 indikator implementasi yang tidak mendukung keberhasilan implementasi SIMPUSTRONIK yaitu pembagian tugas dan wewenang, keikutsertaan pengguna dalam pengembangan implementasi dan keikutsertaan pengguna dalam evaluasi implementasi. Sedang indikator yang diteliti lainnya  menunjukkan adanya hubungan. indikator implementasi tersebut berhubungan erat dengan kesiapan SDM (pengetahuan SDM serta keterkaitan keikutseraan (partisipasi implementor. Hampir semua responden menunjukkan bahwa implementasi SIMPUSTRONIK bermanfaat dan mendukung kegiatan mereka dalam pelayanan KIA, tetapi yang terbesar adalah kemanfaatan penemuan ibu hamil resiko tinggi yang dirujuk.

Razvoj suvremenog menadžmenta trgovine na malo

OpenAIRE

Segetlija, Zdenko

2009-01-01

Razvoj koncentracije u trgovini na malo doveo je do daljnjih promjena u njezinoj strukturi te, u skladu s tim, i do promjena u upravljanju gospodarskim subjektima u trgovini na malo. S tim u svezi mijenja se i dosadašnja paradigma marketinga trgovine na malo, budući da sve važnijim postaje oblikovanje asortimana temeljem programa category managementa i drugih oblika vertikalnoga marketinga. S druge pak strane, osim poznavanja zakonitosti razvoja novih oblika poslovnih jedinica, no...

One More Thing

DEFF Research Database (Denmark)

Schultz, Majken

2014-01-01

Virksomheder kan bruge historien til at være kraftfulde ressourcer for innovation og række langt ind i fremtiden. Tim Cook og Apple viste – igen – vejen ved præsentationen af det nye ur.......Virksomheder kan bruge historien til at være kraftfulde ressourcer for innovation og række langt ind i fremtiden. Tim Cook og Apple viste – igen – vejen ved præsentationen af det nye ur....

The Impact of Divorce Among Marines, E-5 and Below, on Unit Operational Readiness

Science.gov (United States)

2013-04-12

convinced that their relationship is already wonderful. They are equally assured that marriage will simply be a continuation of their present bliss ...Business Review, (November, 2007): 1-9. Call, Vaughn R. A. and Tim B. Heaton, “Religious Influence on Marital Stability,” Journal for the Scientific...bv.1355534169,d.dmQ&fp=facdc1ee60048919&bpcl=40096503 &biw=1024&bih=564. lxvi Vaughn R. A. Call and Tim B. Heaton, “Religious Influence on Marital

Theoretical predictor for candidate structure assignment from IMS data of biomolecule-related conformational space.

Science.gov (United States)

Schenk, Emily R; Nau, Frederic; Fernandez-Lima, Francisco

2015-06-01

The ability to correlate experimental ion mobility data with candidate structures from theoretical modeling provides a powerful analytical and structural tool for the characterization of biomolecules. In the present paper, a theoretical workflow is described to generate and assign candidate structures for experimental trapped ion mobility and H/D exchange (HDX-TIMS-MS) data following molecular dynamics simulations and statistical filtering. The applicability of the theoretical predictor is illustrated for a peptide and protein example with multiple conformations and kinetic intermediates. The described methodology yields a low computational cost and a simple workflow by incorporating statistical filtering and molecular dynamics simulations. The workflow can be adapted to different IMS scenarios and CCS calculators for a more accurate description of the IMS experimental conditions. For the case of the HDX-TIMS-MS experiments, molecular dynamics in the "TIMS box" accounts for a better sampling of the molecular intermediates and local energy minima.

Smoothing effect of the thermal interface material on the temperature distribution in a stepwise varying width microchannel cooling device

Science.gov (United States)

Riera, Sara; Barrau, Jérôme; Rosell, Joan I.; Fréchette, Luc G.; Omri, Mohamed; Vilarrubí, Montse; Laguna, Gerard

2017-09-01

The impact of the thermal interface material (TIM) layer on the performance of a stepwise varying width microchannel cooling device is analysed. A numerical model shows that the TIM layer, besides its well known negative impact on the temperature, also generates a smoothing effect on the temperature distribution. In this study, an analytical model is used to define a nondimensional parameter, called Smoothing Resistance ratio, as the quotient between the origin of the temperature non uniformities and the TIM thermal resistance that flatten the temperature distribution. The relationship between the temperature uniformity of the cooled device, expressed through the temperature standard deviation, and the Smoothing Resistance ratio is shown to be linear. These results lead to the definition of a new design procedure for this kind of cooling device, which aims to reduce the Smoothing Resistance ratio. Two solutions are identified and their drawbacks are analysed.

Evaluasi Prestasi Belajar Mahasiswa Fakultas Teknik Universitas Negeri Yogyakarta

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Imam Muchoyar

2013-09-01

Full Text Available The objectives of this study are: (1 to identify the subjects that have low scores contributing to the low grade point average (GPA of the students and (2 to evaluate the reasons for the low academic achievement among the students. This study was conducted from May 2012 until September 2012. It was an evaluation study.The method used in this study was a comparative descriptive, by comparing the students’ GPA and the categories of the students’ achievement based on the Academic Regulations of Yogyakarta State University. In addition, the study also qualitatively compared the subjects in the departments which have low achievement. The population were all active students of Faculty of Engineering, YSU in the academic year of 2011/2012 who have scores of  below B in more than 3 courses. To evaluate the students who had low GPA, it is used purposive random sampling. The method of data collection used documentation, interviews and questionnaires. The data was analysed using qualitative and quantitative descriptive analysis. The conclusions of this study were: (1 the subjects of the fields study had a very dominant contribution to low GPA of the students. The percentages of the field of study subjects having low achievement in bachelor and associate degree programmes were  84.2% and 87.7% respectively; (2 The reasons  for low achievement of the students  based on the students ‘point of view were: (a the learning implementation aspects, especially from the lecturers (unclear teaching and explanation, inappropriate materials, excessive tasks and homework, the assessment process, (b tight schedule  and (c the intrinsic factors of the students. The reasons based on lecturers ‘point of view were: (a the students’ input (low motivation, low quality, laziness, and (b inadequate learning facilities both in terms of quantity and quality.

Revitalisasi Mahasiswa Fakultas Dakwah dan Komunikasi dalam Islamic Civilazation

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Richway Richway

2016-12-01

Full Text Available Abstrak: Faculty of Dakwah and Communication UIN Raden Fatah Palembang constitute a valuable asset in creating propaganda resources to keep the Islamic Civilization. But the conditions of the students of the Faculty of Dakwah now showing symptoms of pragmatism. Most of them just put the value of academic and forget the obligations and responsibilities as a volunteer custodian of Islamic Civilization in the community. Critical thinking skills in addressing any problems in society increasingly minimal. Hence the need for mental revitalization and strategy in delivering propaganda in society. Hone back critical thinking skills and the ability to write expected to answer the social problems caused by various factors. This effort is expected to also not just limited discourse, but no real steps from the Faculty of Dakwah itself to the revitalization of mental and propaganda strategy.

Structural effects of protein aging: terminal marking by deamidation in human triosephosphate isomerase.

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Ignacio de la Mora-de la Mora

Full Text Available Deamidation, the loss of the ammonium group of asparagine and glutamine to form aspartic and glutamic acid, is one of the most commonly occurring post-translational modifications in proteins. Since deamidation rates are encoded in the protein structure, it has been proposed that they can serve as molecular clocks for the timing of biological processes such as protein turnover, development and aging. Despite the importance of this process, there is a lack of detailed structural information explaining the effects of deamidation on the structure of proteins. Here, we studied the effects of deamidation on human triosephosphate isomerase (HsTIM, an enzyme for which deamidation of N15 and N71 has been long recognized as the signal for terminal marking of the protein. Deamidation was mimicked by site directed mutagenesis; thus, three mutants of HsTIM (N15D, N71D and N15D/N71D were characterized. The results show that the N71D mutant resembles, structurally and functionally, the wild type enzyme. In contrast, the N15D mutant displays all the detrimental effects related to deamidation. The N15D/N71D mutant shows only minor additional effects when compared with the N15D mutation, supporting that deamidation of N71 induces negligible effects. The crystal structures show that, in contrast to the N71D mutant, where minimal alterations are observed, the N15D mutation forms new interactions that perturb the structure of loop 1 and loop 3, both critical components of the catalytic site and the interface of HsTIM. Based on a phylogenetic analysis of TIM sequences, we propose the conservation of this mechanism for mammalian TIMs.

HPTLC Fingerprint Analysis: A Quality Control for Authentication of Herbal Phytochemicals

Science.gov (United States)

Ram, Mauji; Abdin, M. Z.; Khan, M. A.; Jha, Prabhakar

Authentication and consistent quality are the basic requirement for Indian traditional medicine (TIM), Chinese traditional herbal medicine (TCHM), and their commercial products, regardless of the kind of research conducted to modernize the TIM and TCHM. The complexities of TIM and TCHM challenge the current official quality control mode, for which only a few biochemical markers were selected for identification and quantitative assay. Referring too many unknown factors existed in TIM and TCHM, it is impossible and unnecessary to pinpoint qualitatively and quantitatively every single component contained in the herbal drug. Chromatographic fingerprint is a rational option to meet the need for more effective and powerful quality assessment to TIM and TCHM. The optimized chromatographic fingerprint is not only an alternative analytical tool for authentication, but also an approach to express the various pattern of chemical ingredients distribution in the herbal drugs and preserve such "database" for further multifaced sustainable studies. Analytical separation techniques, for example, high-performance liquid chromatography (HPLC), gas chromatography (GC) and mass spectrometry (MS) were among the most popular methods of choice used for quality control of raw material and finished herbal product. Fingerprint analysis approach using high-performance thin-layer chromatography (HPTLC) has become the most potent tool for quality control of herbal medicines because of its simplicity and reliability. It can serve as a tool for identification, authentication, and quality control of herbal drugs. In this chapter, attempts are being made to expand the use of HPTLC and at the same time create interest among prospective researcher in herbal analysis. The developed method can be used as a quality control tool for rapid authentication from a wide variety of herbal samples. Some examples demonstrated the role of fingerprinting in quality control and assessment.

Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase.

Science.gov (United States)

Zhai, Xiang; Amyes, Tina L; Richard, John P

2015-12-09

The side chains of Y208 and S211 from loop 7 of triosephosphate isomerase (TIM) form hydrogen bonds to backbone amides and carbonyls from loop 6 to stabilize the caged enzyme-substrate complex. The effect of seven mutations [Y208T, Y208S, Y208A, Y208F, S211G, S211A, Y208T/S211G] on the kinetic parameters for TIM catalyzed reactions of the whole substrates dihydroxyacetone phosphate and d-glyceraldehyde 3-phosphate [(k(cat)/K(m))(GAP) and (k(cat)/K(m))DHAP] and of the substrate pieces glycolaldehyde and phosphite dianion (k(cat)/K(HPi)K(GA)) are reported. The linear logarithmic correlation between these kinetic parameters, with slope of 1.04 ± 0.03, shows that most mutations of TIM result in an identical change in the activation barriers for the catalyzed reactions of whole substrate and substrate pieces, so that the transition states for these reactions are stabilized by similar interactions with the protein catalyst. The second linear logarithmic correlation [slope = 0.53 ± 0.16] between k(cat) for isomerization of GAP and K(d)(⧧) for phosphite dianion binding to the transition state for wildtype and many mutant TIM-catalyzed reactions of substrate pieces shows that ca. 50% of the wildtype TIM dianion binding energy, eliminated by these mutations, is expressed at the wildtype Michaelis complex, and ca. 50% is only expressed at the wildtype transition state. Negative deviations from this correlation are observed when the mutation results in a decrease in enzyme reactivity at the catalytic site. The main effect of Y208T, Y208S, and Y208A mutations is to cause a reduction in the total intrinsic dianion binding energy, but the effect of Y208F extends to the catalytic site.

Chemically linked metal-matrix nanocomposites of boron nitride nanosheets and silver as thermal interface materials

Science.gov (United States)

Nagabandi, N.; Yegin, C.; Feng, X.; King, C.; Oh, J. K.; Scholar, E. A.; Narumanchi, S.; Akbulut, M.

2018-03-01

Herein, novel hybrid nanocomposite thermal interface materials (TIMs) relying on the chemical linkage of silver, boron nitride nanosheets (BNNSs), and organic ligands are reported. These TIMs were prepared using a co-electrodeposition/chemisorption approach where the electrolytic reduction of silver ions into silver nano-/micro-crystals was coupled with the conjugation of ligand-coated nanosheets onto silver crystals. Furthermore, the influence of the bond strength of silver/nanosheet links on the thermal, mechanical, and structural properties is investigated using a combination of techniques including laser flash analysis, phase-sensitive transient thermoreflectance, nanoindentation, and electron microscopy. The internal nanostructure was found to be strongly dependent on the linker chemistry. While the chemical grafting of 4-cyano-benzoyl chloride (CBC) and 2-mercapto-5-benzimidazole carboxylic acid (MBCA) on BNNSs led to the uniform distribution of functionalized-nanosheets in the silver crystal matrix, the physical binding of 4-bromo-benzoyl chloride linkers on nanosheets caused the aggregation and phase separation. The thermal conductivity was 236-258 W m-1 K and 306-321 W m-1 K for physically and chemically conjugated TIMs, respectively, while their hardness varied from 400-495 MPa and from 240 to 360 MPa, respectively. The corresponding ratio of thermal conductivity to hardness, which is a critical parameter controlling the performance of TIMs, was ultrahigh for the chemically conjugated TIMs: 1.3 × 10-6 m2 K-1 s for MBCA-BNNS and 8.5 × 10-7 m2 K-1 s for CBC-BNNS. We anticipate that these materials can satisfy some of the emerging thermal management needs arising from the improved performance and efficiency, miniaturization, and/or high throughput of electronic devices, energy storage devices, energy conversion systems, light-emitting diodes, and telecommunication components.

CERN LHC Technical Infrastructure Monitoring (TIM)

CERN Document Server

Epting, U; Martini, R; Sollander, P; Bartolomé, R; Vercoutter, B; Morodo-Testa, M C

1999-01-01

The CERN Large Hadron Collider (LHC) will start to deliver particles to its experiments in the year 2005. However, all the primary services such as electricity, cooling, ventilation, safety systems and others such as vacuum and cryogenics will be commissioned gradually between 2001 and 2005. This technical infrastructure will be controlled using industrial control systems, which have either already been purchased from specialized companies or are currently being put together for tender. This paper discusses the overall architecture and interfaces that will be used by the CERN Technical Control Room (TCR) to monitor the technical services at CERN and those of the LHC and its experiments. The issue of coherently integrating existing and future control systems over a period of five years with constantly evolving technology is addressed. The paper also summarizes the functionality of all the tools needed by the control room such as alarm reporting, data logging systems, man machine interfaces and the console mana...

Un TIM verde para el POT

OpenAIRE

Duque Escobar, Gonzalo

2014-01-01

Manizales, que tampoco escapa a los problemas causados por la proliferación de carros y motos, y la congestión vehicular, debe integrar dos objetivos al POT: más transporte público colectivo y masivo, y mas ciclovías y rutas peatonales para viajes no motorizados

A Waterman's Journey: Tim Junkin's Bloodsworth

Science.gov (United States)

Ward, Nathan

2004-01-01

Before he was wrongly sent to death row for the rape and murder of a nine-year-old girl in 1984, Kirk Bloodsworth enjoyed the life of a Chesapeake Bay waterman. Convicted largely on the testimony of a seven- and a ten-year-old eyewitness, by 1989 Johnson had exhausted almost every legal option available--after winning a new trial, he was convicted…

PELAKSANAAN REHABILITASI BAGI PECANDU NARKOTIKA PASCA BERLAKUNYA PERATURAN BERSAMA 7 (TUJUH LEMBAGA NEGARA REPUBLIK INDONESIA

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Dani Krisnawati

2015-10-01

Full Text Available This study is a normative-empirical research that use secondary and primary data. In the case of a voluntary reporting to the Sleman Police Precinct investigator by the drug addicts, the case will be coordinated tothe medical and/or social rehabilitation agency, in this case is PSPP. However, after the implementationof Joint Regulation, no drug addicts voluntarily reported themselves. Whenever the suspects of thedrug addiction that were caught, the Sleman Police Precinct investigator which is the element of lawenforcement team beside the Sleman Narcotics National Agency, Sleman District Attorney, and RegionalOffice of the Ministry of Law and Human Rights Yogyakarta Province, coordinate themselves as a part ofa joint assessment team, including with the Bhayangkara Hospital and Grhasia Hospital which serve asthe medical doctor team. Penelitian ini merupakan penelitian normatif empiris yang mengolah data primer dan sekunder. Hasil penelitian menunjukkan bahwa tindakan penyidik pasca berlakunya Peraturan Bersama terhadap pecanduyang secara sukarela melaporkan diri ke penyidik Polres Sleman, akan dikoordinasikan ke lembaga medisdan/atau sosial, dalam hal ini Panti Sosial Pamardi Putra. Meskipun pasca berlakunya Peraturan Bersamabelum ada pecandu yang secara sukarela melaporkan diri, sedangkan bagi tersangka pecandu narkotikayang ditangkap, penyidik Polres Sleman saling berkoordinasi dengan tim hukum yang lain sebagai bagiandari tim assessment terpadu dan tim dokter dari Rumah Sakit Bhayangkara dan Rumah Sakit Grhasia yangmerupakan bagian dari tim dokter.

PELAKSANAAN REHABILITASI BAGI PECANDU NARKOTIKA PASCA BERLAKUNYA PERATURAN BERSAMA 7 (TUJUH LEMBAGA NEGARA REPUBLIK INDONESIA

Directory of Open Access Journals (Sweden)

Dani Krisnawati

2015-10-01

Full Text Available This study is a normative-empirical research that use secondary and primary data. In the case of a voluntary reporting to the Sleman Police Precinct investigator by the drug addicts, the case will be coordinated tothe medical and/or social rehabilitation agency, in this case is PSPP. However, after the implementationof Joint Regulation, no drug addicts voluntarily reported themselves. Whenever the suspects of thedrug addiction that were caught, the Sleman Police Precinct investigator which is the element of lawenforcement team beside the Sleman Narcotics National Agency, Sleman District Attorney, and RegionalOffice of the Ministry of Law and Human Rights Yogyakarta Province, coordinate themselves as a part ofa joint assessment team, including with the Bhayangkara Hospital and Grhasia Hospital which serve asthe medical doctor team.   Penelitian ini merupakan penelitian normatif empiris yang mengolah data primer dan sekunder. Hasil penelitian menunjukkan bahwa tindakan penyidik pasca berlakunya Peraturan Bersama terhadap pecanduyang secara sukarela melaporkan diri ke penyidik Polres Sleman, akan dikoordinasikan ke lembaga medisdan/atau sosial, dalam hal ini Panti Sosial Pamardi Putra. Meskipun pasca berlakunya Peraturan Bersamabelum ada pecandu yang secara sukarela melaporkan diri, sedangkan bagi tersangka pecandu narkotikayang ditangkap, penyidik Polres Sleman saling berkoordinasi dengan tim hukum yang lain sebagai bagiandari tim assessment terpadu dan tim dokter dari Rumah Sakit Bhayangkara dan Rumah Sakit Grhasia yangmerupakan bagian dari tim dokter.

The stability and formation of native proteins from unfolded monomers is increased through interactions with unrelated proteins.

Directory of Open Access Journals (Sweden)

Claudia Rodríguez-Almazán

Full Text Available The intracellular concentration of protein may be as high as 400 mg per ml; thus it seems inevitable that within the cell, numerous protein-protein contacts are constantly occurring. A basic biochemical principle states that the equilibrium of an association reaction can be shifted by ligand binding. This indicates that if within the cell many protein-protein interactions are indeed taking place, some fundamental characteristics of proteins would necessarily differ from those observed in traditional biochemical systems. Accordingly, we measured the effect of eight different proteins on the formation of homodimeric triosephosphate isomerase from Trypanosoma brucei (TbTIM from guanidinium chloride unfolded monomers. The eight proteins at concentrations of micrograms per ml induced an important increase on active dimer formation. Studies on the mechanism of this phenomenon showed that the proteins stabilize the dimeric structure of TbTIM, and that this is the driving force that promotes the formation of active dimers. Similar data were obtained with TIM from three other species. The heat changes that occur when TbTIM is mixed with lysozyme were determined by isothermal titration calorimetry; the results provided direct evidence of the weak interaction between apparently unrelated proteins. The data, therefore, are strongly suggestive that the numerous protein-protein interactions that occur in the intracellular space are an additional control factor in the formation and stability of proteins.

Geographical analysis of diapause inducibility in European Drosophila melanogaster populations.

Science.gov (United States)

Pegoraro, Mirko; Zonato, Valeria; Tyler, Elizabeth R; Fedele, Giorgio; Kyriacou, Charalambos P; Tauber, Eran

2017-04-01

Seasonal overwintering in insects represents an adaptation to stressful environments and in European Drosophila melanogaster females, low temperatures and short photoperiods can induce an ovarian diapause. Diapause may represent a recent (melanogaster from tropical sub-Saharan Africa, because African D. melanogaster and the sibling species D. simulans, have been reported to fail to undergo diapause. Over the past few centuries, D. melanogaster have also invaded North America and Australia, and eastern populations on both continents show a predictable latitudinal cline in diapause induction. In Europe however, a new diapause-enhancing timeless allele, ls-tim, is observed at high levels in southern Italy (∼80%), where it appears to have arisen and has spread throughout the continent with a frequency of ∼20% in Scandinavia. Given the phenotype of ls-tim and its geographical distribution, we might predict that it would work against any latitudinal cline in diapause induction within Europe. Indeed we reveal that any latitudinal cline for diapause in Europe is very weak, as predicted by ls-tim frequencies. In contrast, we determine ls-tim frequencies in North America and observe that they would be expected to strengthen the latitudinal pattern of diapause. Our results reveal how a newly arisen mutation, can, via the stochastic nature of where it initially arose, blur an otherwise adaptive geographical pattern. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Technology and Innovation Management Indicators and Assessment Based on Government Performance

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Sanja Marinković

2016-05-01

Full Text Available Throughout large global databases, such as OECD, UNDP, ITU, Eurostat, World Bank, and Statistical offices of countries, there are many indicators that refer to Technology and Innovation Management (TIM performance of countries. However, a question arises of how to classify and systematically analyze these indicators in terms of measuring, monitoring and enhancing TIM performance at a national level. More specifically, in this paper we pose a question of how to assess the government performance in TIM, as one aspect of the Triple Helix model. Therefore, we use a model of thirty-nine indicators which are classified according to three main management functions: planning, organizing and control, observed as input, process and output, respectively. More importantly, we analyze the relations that exist between these three categories of indicators. Planning indicators are observed as the investments in technological and innovative activities; organizing indicators include the infrastructure, public administration efficiency and cooperation support, while control indicators refer to the national economy R&D, transfer effects and entrepreneurship outcomes. The model is tested for assessing and comparing government performance in TIM for three countries: Serbia, Croatia and Slovenia, for the time period 2007-2012. Finally, as a feedback in the model, we used scores of the countries according to the Global Innovation Index and the Global Competitiveness Index, to verify the results and provide the final conclusion.

Comparative Analysis of Putative Orthologues of Mitochondrial Import Motor Subunit: Pam18 and Pam16 in Plants

OpenAIRE

Chen, Xuejin; Ghazanfar, Bushra; Khan, Abdul Rehman; Hayat, Sikandar; Cheng, Zhihui

2013-01-01

Pam18/Tim14 and Pam16/Tim16, highly conserved proteins among eukaryotes, are two essential subunits of protein import motors localized in the inner mitochondrial membrane. The heterodimer formed by Pam18 and Pam16 via their J-type domains serves a regulatory function in protein translocation. Here, we report that thirty-one Pam18 and twenty-six Pam16 putative orthologues in twelve plant species were identified and analyzed through bioinformatics strategy. Results data revealed that Pam18 and ...

Research to Quantify the Effect of Permanent Change of Station Moves on Wives’ Wages and Labor Supply.

Science.gov (United States)

1983-01-01

psychic costs and reduces incomes of family members. Spouses and other dependents mast give up jobs and take time to make the move. The Navy...tine only find, wanted, slack, unable 8. why no work hone, school, can’t find, other 9. weeks worked 10. weeks worked part-time 11. weeks unemployed ...Status March 1976 15. full-tim 16. part-tim T-7-1 i 17. unemployed /looking:I 18. keeping house 19. other Demographic Characteristics 20. wife living

Remote detection of canopy water stress in coniferous forests using the NS001 Thematic Mapper Simulator and the thermal infrared multispectral scanner

Science.gov (United States)

Pierce, Lars L.; Running, Steven W.; Riggs, George A.

1990-01-01

Water stress was induced in two coniferous forest stands in West Germany by severing tree sapwood. Leaf water potential, Psi(L), measurements indicated that maximum, naturally occurring levels of water stress developed in the stressed plots while control plots exhibited natural diurnal trends. Images of each site were obtained with the Thematic Mapper Simulator (NS001) and the Thermal Infrared Multispectral Scanner (TIMS) 12 to 15 days after stress induction. NS001 bands 2 to 6, NS001 indices combining bands 4 and 6, and NS001 and TIMS thermal bands showed significant radiance differences between stressed and control plots when large differences in Psi(L) and relative water content (RWC) existed during the morning overflights at Munich. However, the NS001 and TIMS sensors could not detect the slightly smaller differences in Psi(L) and RWC during the Munich afternoon and Frankfurt overflights. The results suggest that routine detection of canopy water stress under operational conditions is difficult utilizing current sensor technology.

Measurements and modeling of total solar irradiance in X-class solar flares

International Nuclear Information System (INIS)

Moore, Christopher Samuel; Chamberlin, Phillip Clyde; Hock, Rachel

2014-01-01

The Total Irradiance Monitor (TIM) from NASA's SOlar Radiation and Climate Experiment can detect changes in the total solar irradiance (TSI) to a precision of 2 ppm, allowing observations of variations due to the largest X-class solar flares for the first time. Presented here is a robust algorithm for determining the radiative output in the TIM TSI measurements, in both the impulsive and gradual phases, for the four solar flares presented in Woods et al., as well as an additional flare measured on 2006 December 6. The radiative outputs for both phases of these five flares are then compared to the vacuum ultraviolet (VUV) irradiance output from the Flare Irradiance Spectral Model (FISM) in order to derive an empirical relationship between the FISM VUV model and the TIM TSI data output to estimate the TSI radiative output for eight other X-class flares. This model provides the basis for the bolometric energy estimates for the solar flares analyzed in the Emslie et al. study.

Implementation of competency-and-conservation-based curriculum to improve graduates’ quality to be competent and conservation-minded

Directory of Open Access Journals (Sweden)

Asrori Asrori

2017-01-01

Full Text Available This study was aimed to analyze how the implementation of Kurikulum Berbasis Kompetensi dan Konservasi or Competency-and-Conservation-Based Curriculum (KBKK improves the quality of graduates from Faculty of Economics of Universitas Negeri Semarang (UNNES. The goal of this study was to provide information and policy recommendations to improve the quality of graduates based on behavior lectures. The respondents of this research were lecturers of Faculty of Economics. Research data were collected using questionnaires to dig up information on the implementation of KBKK, lecturers’ ability and commitment to implement KBKK. Descriptive statistics and inferential statistical multiple linear regression were employed to analyze data. This study provided empirical support that lecturers’ ability and commitment positively contributed to the implementation of KBKK to improve the quality of graduates to be competent and conservation-minded. This study also proved that while lecturers’ ability and commitment play an important role, their commitment does not affect the implementation KBKK. Based on the results of this study, it is recommended that lecturers’ ability to implement KBKK needs to be improved. Workshops and training should be given to lecturers to help them create learning apparatus such as syllabus, lesson plans and teaching materials, as well as the evaluation of KBKK.Penelitian ini bertujuan untuk menganalisis bagaimana penerapan kurikulum berbasis kompetensi dan konservasi (KBKK mampu meningkatkan kualitas lulusan Fakultas Ekonomi universitas negeri Semarang. Urgensi dari penelitian ini adalah untuk memeberikan informasi dan rekomendasi kebijakan untuk meningkatkankualitas lulusan melalui kompetensi dosen. Penelitian ini dilakukan terhadap dosen dilingkungan Fakultas Ekonomi. Pengumpulan data dilakukan dengan mengunakan angket, untuk menggali informasi penerapan Kurikulum berbasis Kompetensi dan onservasi (KBKK, kemampuan dosen, dan

PENGEMBANGAN KINERJA PERAWAT TERHADAP PENCEGAHAN INFEKSI FLEBITIS DI RUMAH SAKIT

Directory of Open Access Journals (Sweden)

Noor Amaliah

2017-09-01

Full Text Available Flebitis merupakan masalah serius karena mengancam kesehatan dan keselamatan pasien. Flebitis mempunyai dampak terhadap kualitas pelayanan dan peningkatan pembiayaan pelayanan kesehatan. Kejadian flebitis yang tinggi mencerminkan rendahnya mutu pelayanan keperawatan dalam hal pencegahan dan pengendalian infeksi. Tujuan dari penelitian ini menganalisis pengembangan model kinerja perawat terhadap pencegahan infeksi flebitis di Rumah Sakit Islam Banjarmasin. Penelitian ini menggunakan metode kuantitatif dengan desain Explanatory Research menggunakan pendekatan cross sectional dan Focus Group Discussion. Populasi 69 orang perawat pelaksana. Sampel berjumlah 65 responden. Tekhnik sampling menggunakan purposive sampling. Hasil penelitian ini adalah tidak terdapat pengaruh faktor individu, faktor psikologis dan faktor organisasi terhadap kinerja perawat terhadap pencegahan infeksi flebitis dengan nilai T-Statistik > 1,96 dan p Value < 0,05. Kesimpulan penelitian adalah tidak terdapat pengaruh faktor-faktor yang mempengaruhi kinerja perawat terhadap pencegahan infeksi flebitis. Saran dari penelitian ini diharapkan agar perawat dapat meningkatkan kinerjanya terhadap pencegahan infeksi flebitis melalui sikap, motivasi maupun dukungan dari supervisi.

2002 Industry Studies: News Media

Science.gov (United States)

2002-01-01

USAF CAPT John W. Coleman II, USN Reserve Col Christos Dellas , Greek Army Col Tim Fletcher USAF Lt Col Tim Malinski USAF Lt Col Deb Martinez USAF Ms...Majority Support Government Restrictions on War Coverage,” Washington Post, 29 November 2001, Sec. C, p.1. 54 Lucia Moses, “E&P Survey: Circ Bump was...Afghan War,” The Washington Post, 7 December 2001, Sec. A, p. 43. Moses, Lucia , “E&P Survey: Circ Bump was Modest,” Editor & Publisher, 22 April 2002

Mobilā lietotne: "Instagram bilžu plānotājs"

OpenAIRE

Cibuļskis, Aigars

2016-01-01

Šajā dokumentā ir iekļauta Latvijas Universitātes Datorikas fakultātes kursa “Kvalifikācijas darbs II” (DatZ2049) praktiskā darba ietvaros izstrādātā lietotne “Mobila lietotne “Instagram bilžu plānotājs”” tehniskā dokumentācija, kas ietver programmatūras prasību specifikāciju, datu bāzes un ekrānformu projektējumus. Instagram bilžu plānotājs - ir lietotne Android platformai, kura domāta atvieglot bilžu izlikšanu sociālajā tīklā Instagram, modes blogeriem un mā...

Doping ve fitness a rekreační sport : obsahová analýza českých videí na YouTube

OpenAIRE

Miček, Jakub

2016-01-01

Bibliografický záznam MIČEK, Jakub. Doping ve fitness a rekreační sport: obsahová analýza českých videí na YouTube. Praha, 2016. 48 s. Bakalářská práce (Bc.) Univerzita Karlova. Fakulta sociálních věd, Institut sociologických důvodů. Katedra sociologie. Vedoucí bakalářské práce PhDr. Mgr. Jan Balon, Ph.D. Abstract Fitness and YouTube are very popular areas of entertainment these days. Despite the touchiness of this topic, there are many videos about doping being published on YouTube. Majority...

Two new nuclear isolation buffers for plant DNA flow cytometry: A test with 37 species

Czech Academy of Sciences Publication Activity Database

Loureiro, J.; Rodriguez, E.; Doležel, Jaroslav; Santos, C.

2007-01-01

Roč. 100, č. 4 (2007), s. 875-888 ISSN 0305-7364 R&D Projects: GA ČR GA521/06/1723; GA ČR(CZ) GA521/05/0257; GA MŠk(CZ) LC06004 Grant - others:Mendelova zemědělská a lesnická univerzita v Brně / Agronomická fakulta(CZ) ME 844 Institutional research plan: CEZ:AV0Z50380511 Source of funding: V - iné verejné zdroje ; V - iné verejné zdroje ; V - iné verejné zdroje ; V - iné verejné zdroje Keywords : flow cytometry * general purpose buffer * genome size Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.939, year: 2007

A review on the determination of isotope ratios of boron with mass spectrometry.

Science.gov (United States)

Aggarwal, Suresh Kumar; You, Chen-Feng

2017-07-01

The present review discusses different mass spectrometric techniques-viz, thermal ionization mass spectrometry (TIMS), inductively coupled plasma mass spectrometry (ICPMS), and secondary ion mass spectrometry (SIMS)-used to determine 11 B/ 10 B isotope ratio, and concentration of boron required for various applications in earth sciences, marine geochemistry, nuclear technology, environmental, and agriculture sciences, etc. The details of the techniques-P-TIMS, which uses Cs 2 BO 2 + , N-TIMS, which uses BO 2 - , and MC-ICPMS, which uses B + ions for bulk analysis or B - and B + ions for in situ micro-analysis with SIMS-are highlighted. The capabilities, advantages, limitations, and problems in each mass spectrometric technique are summarized. The results of international interlaboratory comparison experiments conducted at different times are summarized. The certified isotopic reference materials available for boron are also listed. Recent developments in laser ablation (LA) ICPMS and QQQ-ICPMS for solids analysis and MS/MS analysis, respectively, are included. The different aspects of sample preparation and analytical chemistry of boron are summarized. Finally, the future requirements of boron isotope ratios for future applications are also given. Presently, MC-ICPMS provides the best precision and accuracy (0.2-0.4‰) on isotope ratio measurements, whereas N-TIMS holds the potential to analyze smallest amount of boron, but has the issue of bias (+2‰ to 4‰) which needs further investigations. © 2016 Wiley Periodicals, Inc. Mass Spec Rev 36:499-519, 2017. © 2016 Wiley Periodicals, Inc.

Religious Imagery in Popular Music Theatre

DEFF Research Database (Denmark)

Eigtved, Michael

2007-01-01

Artiklen undersøger hvordan religiøse billeder, narrative strategier og andre elementer er en del af musicalgenren. Der foretages en mere indgående analyse af Richard Rodgers' og Oscar Hammersteins forestilling Carousel samt af Andrew LLoyd Webber og Tim Rices forestilling Evita.......Artiklen undersøger hvordan religiøse billeder, narrative strategier og andre elementer er en del af musicalgenren. Der foretages en mere indgående analyse af Richard Rodgers' og Oscar Hammersteins forestilling Carousel samt af Andrew LLoyd Webber og Tim Rices forestilling Evita....

The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1▿

Science.gov (United States)

Allen, Sariah J.; Hamrah, Pedram; Gate, David; Mott, Kevin R.; Mantopoulos, Dimosthenis; Zheng, Lixin; Town, Terrence; Jones, Clinton; von Andrian, Ulrich H.; Freeman, Gordon J.; Sharpe, Arlene H.; BenMohamed, Lbachir; Ahmed, Rafi; Wechsler, Steven L.; Ghiasi, Homayon

2011-01-01

Herpes simplex virus (HSV) infection is a classic example of latent viral infection in humans and experimental animal models. The HSV-1 latency-associated transcript (LAT) plays a major role in the HSV-1 latency reactivation cycle and thus in recurrent disease. Whether the presence of LAT leads to generation of dysfunctional T cell responses in the trigeminal ganglia (TG) of latently infected mice is not known. To address this issue, we used LAT-positive [LAT(+)] and LAT-deficient [LAT(−)] viruses to evaluate the effect of LAT on CD8 T cell exhaustion in TG of latently infected mice. The amount of latency as determined by quantitative reverse transcription-PCR (qRT-PCR) of viral DNA in total TG extracts was 3-fold higher with LAT(+) than with LAT(−) virus. LAT expression and increased latency correlated with increased mRNA levels of CD8, PD-1, and Tim-3. PD-1 is both a marker for exhaustion and a primary factor leading to exhaustion, and Tim-3 can also contribute to exhaustion. These results suggested that LAT(+) TG contain both more CD8+ T cells and more CD8+ T cells expressing the exhaustion markers PD-1 and Tim-3. This was confirmed by flow cytometry analyses of expression of CD3/CD8/PD-1/Tim-3, HSV-1, CD8+ T cell pentamer (specific for a peptide derived from residues 498 to 505 of glycoprotein B [gB498–505]), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α). The functional significance of PD-1 and its ligands in HSV-1 latency was demonstrated by the significantly reduced amount of HSV-1 latency in PD-1- and PD-L1-deficient mice. Together, these results may suggest that both PD-1 and Tim-3 are mediators of CD8+ T cell exhaustion and latency in HSV-1 infection. PMID:21307196

Essentials of iron, chromium, and calcium isotope analysis of natural materials by thermal ionization mass spectrometry

Science.gov (United States)

Fantle, M.S.; Bullen, T.D.

2009-01-01

The use of isotopes to understand the behavior of metals in geological, hydrological, and biological systems has rapidly expanded in recent years. One of the mass spectrometric techniques used to analyze metal isotopes is thermal ionization mass spectrometry, or TIMS. While TIMS has been a useful analytical technique for the measurement of isotopic composition for decades and TIMS instruments are widely distributed, there are significant difficulties associated with using TIMS to analyze isotopes of the lighter alkaline earth elements and transition metals. Overcoming these difficulties to produce relatively long-lived and stable ion beams from microgram-sized samples is a non-trivial task. We focus here on TIMS analysis of three geologically and environmentally important elements (Fe, Cr, and Ca) and present an in-depth look at several key aspects that we feel have the greatest potential to trouble new users. Our discussion includes accessible descriptions of different analytical approaches and issues, including filament loading procedures, collector cup configurations, peak shapes and interferences, and the use of isotopic double spikes and related error estimation. Building on previous work, we present quantitative simulations, applied specifically in this study to Fe and Ca, that explore the effects of (1) time-variable evaporation of isotopically homogeneous spots from a filament and (2) interferences on the isotope ratios derived from a double spike subtraction routine. We discuss how and to what extent interferences at spike masses, as well as at other measured masses, affect the double spike-subtracted isotope ratio of interest (44Ca/40Ca in the case presented, though a similar analysis can be used to evaluate 56Fe/54Fe and 53Cr/52Cr). The conclusions of these simulations are neither intuitive nor immediately obvious, making this examination useful for those who are developing new methodologies. While all simulations are carried out in the context of a

A new method for calibrating the current gain of 1013 Ω amplifiers in thermal ionization mass spectrometry.

Science.gov (United States)

Wang, Guiqin; Zeng, Yuling; Xu, Jifeng; Liu, Wengui

2018-03-09

We report a new method for calibrating the current gain of 10 13 Ω amplifiers in both positive and negative mode used in thermal ionisation mass spectrometry (TIMS). This method uses any isotopic standard or sample to calibrate the gain factor as long as it can produce a stable current signal. It is simpler and more flexible than that recommended by Thermo-Fisher (the manufacture of the TIMS). In these analyses, the gains of five 10 13 Ω amplifiers were assessed. The precision of gain factors was better than 100 ppm (2 RSD) in a day, and the long term reproducibility was better than 300 ppm (2 RSD) within 2 - 8 months. After a gain was calibrated, the ratio accuracy and precision in the positive mode for 87 Sr/ 88 Sr of NIST 987 Sr and 143 Nd/ 144 Nd of La Jolla Nd were 0.710242 ± 60 (2 SD, n = 14) and 0.511842 ± 10 (2 SD, n = 22), respectively, at intensities of 88 Sr 0.3 V and 142 Nd 0.4 V, while in the negative mode for 187 Os/ 188 Os of Merck Os was 0.120229± 34 (2 SD, n = 23) at an intensity of 187 OsO 3 0.01 mV. In addition, a difference in the gain factors between the negative mode TIMS (NTIMS) and positive mode TIMS (PTIMS) has been recognized. The values of the gain factor for NTIMS and PTIMS show a deviation of 0.54% on the Triton and 0.31% on the Triton Plus TIMS in this study; therefore, gain calibration should be carried out on both NTIMS and PTIMS. Moreover, a bias of ~ 1.5×10 -5 between H and L Faraday cups for the same 10 13 Ω amplifier has been detected, hinting that the efficiency of different Faraday cups may affect the gain factors, which can be eliminated through the new method of "cross-calibration" discribed in this study. This article is protected by copyright. All rights reserved.

Thermal cycling fatigue of organic thermal interface materials using a thermal-displacement measurement technique

Science.gov (United States)

Steill, Jason Scott

The long term reliability of polymer-based thermal interface materials (TIM) is essential for modern electronic packages which require robust thermal management. The challenge for today's materials scientists and engineers is to maximize the heat flow from integrated circuits through a TIM and out the heat sink. Thermal cycling of the electronic package and non-uniformity in the heat flux with respect to the plan area can lead to void formation and delamination which re-introduces inefficient heat transfer. Measurement and understanding at the nano-scale is essential for TIM development. Finding and documenting the evolution of the defects is dependent upon a full understanding of the thermal probes response to changing environmental conditions and the effects of probe usage. The response of the thermal-displacement measurement technique was dominated by changes to the environment. Accurate measurement of the thermal performance was hindered by the inability to create a model system and control the operating conditions. This research highlights the need for continued study into the probe's thermal and mechanical response using tightly controlled test conditions.

Vague but exciting…CERN celebrates 20 years of the Web

CERN Multimedia

2009-01-01

Twenty years ago work started on something that would change the world forever. It would change the way we work, the way we communicate and the way we make our voices heard. On 13 March CERN will celebrate the 20th anniversary of the birth of the World Wide Web. Tim Berners-Lee with Nicola Pellow, next to the NeXT computer.In March 1989 here at CERN, Tim Berners-Lee submitted a proposal for a new information management system to his boss, Mike Sendall. ‘Vague, but exciting’, were the words that Sendall wrote on the proposal, allowing Berners-Lee to continue with the project, but unaware that it would evolve into one of the most important communication tools ever created. Tim Berners-Lee used a NeXT computer at CERN to create the first web server running a single website – info.cern.ch. Since then the World Wide Web has grown into the incredible phenomenon that we know today, a web of more than 60 billion pages, and hundreds of ...

Morning and Evening Oscillators Cooperate to Reset Circadian Behavior in Response to Light Input

Directory of Open Access Journals (Sweden)

Pallavi Lamba

2014-05-01

Full Text Available Light is a crucial input for circadian clocks. In Drosophila, short light exposure can robustly shift the phase of circadian behavior. The model for this resetting posits that circadian photoreception is cell autonomous: CRYPTOCHROME senses light, binds to TIMELESS (TIM, and promotes its degradation, which is mediated by JETLAG (JET. However, it was recently proposed that interactions between circadian neurons are also required for phase resetting. We identify two groups of neurons critical for circadian photoreception: the morning (M and the evening (E oscillators. These neurons work synergistically to reset rhythmic behavior. JET promotes acute TIM degradation cell autonomously in M and E oscillators but also nonautonomously in E oscillators when expressed in M oscillators. Thus, upon light exposure, the M oscillators communicate with the E oscillators. Because the M oscillators drive circadian behavior, they must also receive inputs from the E oscillators. Hence, although photic TIM degradation is largely cell autonomous, neural cooperation between M and E oscillators is critical for circadian behavioral photoresponses.

Vi behøver innovation

DEFF Research Database (Denmark)

McAloone, Tim C.

2007-01-01

-Produktion og Maskiner. Innovation og bæredygtighed er to områder som vi i Skandinavien giver meget stor opmærksomhed for at kunne vedligeholde vores globale konkurrencekraft og stærke velfærdssamfund. Gennem årene har mange brancher bidraget til skabelsen af vidensbaserede innovationer, og det faktum, at de......Analyse: Vi behøver innovation En ny miljøbølge ruller, og danske virksomheder bør ride med Af Tim McAloone, fredag 02. feb 2007 kl. 04:50 Tim McAloone Lektor og ph.d. ved Institut for mekanik, energi og konstruktion ved DTU. Tim McAloone skriver fremover jævnligt kommentarer i Ingeniøren...... skandinaviske lande er relativt små, har ledt til en interessant evne til at etablere og derefter samarbejde inden for tætte netværk, som strækker sig over både faglige og geografiske grænser. Samtidig har vi set miljøhensyn vinde og tabe samfundsmæssig og industriel opmærksomhed på en nærmest periodisk basis...

Perancangan Sistem Informasi Data Alumni Fakultas Teknik Unsrat Berbasis Web

OpenAIRE

Watung, Ivan Arifard; Sinsuw, Alicia A. E

2014-01-01

Information technology has become the primary choice in creating an information system that can provide accurate and precise information. Backround of alumni data information system that is still manual data processing. The purpose of this system is to design a web-based information system. System design using the waterfall method comprising steps Information System Engineering, Requirements Analysis, Design, Coding, Testing, and Maintenance. Modeling using Flowmap or Flowchart, Context Diagr...

EMPATI DAN PEMAAFAN PADA MAHASISWA FAKULTAS PSIKOLOGI UIN SUSKA RIAU

Directory of Open Access Journals (Sweden)

Dwi Indra Lestari

2016-10-01

Full Text Available Forgiveness has one important in human interpersonal relation.The purpose of this study was to examine the relationship between empathy and forgiveness on undergraduate student. The participants undergraduate student were 309 (47: men, 262, women from faculty of Psychology UIN Suska Riau.  This research used two kinds of scale, empathy  and forgiveness scale.The result showed: there is a significant and positive correlation  between empathy and forgiveness.. The  Implication of this result are discussed on the interpersonal relation contexts.

A novel lineage of myoviruses infecting cyanobacteria is widespread in the oceans.

Science.gov (United States)

Sabehi, Gazalah; Shaulov, Lihi; Silver, David H; Yanai, Itai; Harel, Amnon; Lindell, Debbie

2012-02-07

Viruses infecting bacteria (phages) are thought to greatly impact microbial population dynamics as well as the genome diversity and evolution of their hosts. Here we report on the discovery of a novel lineage of tailed dsDNA phages belonging to the family Myoviridae and describe its first representative, S-TIM5, that infects the ubiquitous marine cyanobacterium, Synechococcus. The genome of this phage encodes an entirely unique set of structural proteins not found in any currently known phage, indicating that it uses lineage-specific genes for virion morphogenesis and represents a previously unknown lineage of myoviruses. Furthermore, among its distinctive collection of replication and DNA metabolism genes, it carries a mitochondrial-like DNA polymerase gene, providing strong evidence for the bacteriophage origin of the mitochondrial DNA polymerase. S-TIM5 also encodes an array of bacterial-like metabolism genes commonly found in phages infecting cyanobacteria including photosynthesis, carbon metabolism and phosphorus acquisition genes. This suggests a common gene pool and gene swapping of cyanophage-specific genes among different phage lineages despite distinct sets of structural and replication genes. All cytosines following purine nucleotides are methylated in the S-TIM5 genome, constituting a unique methylation pattern that likely protects the genome from nuclease degradation. This phage is abundant in the Red Sea and S-TIM5 gene homologs are widespread in the oceans. This unusual phage type is thus likely to be an important player in the oceans, impacting the population dynamics and evolution of their primary producing cyanobacterial hosts.

Herbal Remedies for Functional Dyspepsia and Traditional Iranian Medicine Perspective

Science.gov (United States)

Babaeian, Mahmoud; Naseri, Mohsen; Kamalinejad, Mohammad; Ghaffari, Farzaneh; Emadi, Fatemeh; Feizi, Awat; Hosseini Yekta, Nafiseh; Adibi, Peyman

2015-01-01

Context: Functional dyspepsia (FD) is a functional gastro-intestinal disorder with high prevalence. Among various treatment options, treatment by complementary and alternative medicines especially herbal remedies also practiced. Traditional Iranian medicine (TIM), a valuable resource of valid applied studies of ancient Iranian scholars, recommends numerous medicinal plants to treat dyspepsia symptoms. In this study, through investigation of TIM references, we aimed to identify medicinal plants for treatment of digestion insufficiency. Evidence Acquisition: In this qualitative study, dyspepsia symptoms including fullness, early satiety, bloating, nausea, and belching were checked under reliable sources of traditional medicine. Then medicinal plants recommended for the treatment of the symptoms were extracted from the books. Likewise, for investigating the pharmacological properties of medicinal plants used for the relieving of dyspepsia symptoms, electronic databases such as PubMed, Scopus, Google Scholar and some Iranian databases like SID and IranMedex were employed. Results: The study yielded 105 plants from 37 families which could treat various dyspepsia symptoms; fifty-seven plants, mainly from Apiaceae, Lamiaceae, Amaryllidaceae and Zingiberaceae had digestive effects. In this research, based on the information in TIM reference texts, we obtained 58 plants effective for bloating, 40 for nausea, 37 for appetite loss and 7 for belching. In human clinical trials conducted on medicinal plants effective for FD symptoms, 7 single plants were used. Conclusions: Finding the medicinal plants effective on digestion insufficiency based on TIM could suggest a better strategy for the relieving of dyspepsia symptoms. Traditional Iranian medicine prescribes medicinal plants based on each patient’s personal characteristics and practices multiple target therapies. PMID:26734483

Contribution of bulk mass spectrometry isotopic analysis to characterization of materials in the framework of CMX-4

International Nuclear Information System (INIS)

Kuchkin, A.; Stebelkov, V.; Zhizhin, K.; Lierse von Gostomski, Ch.; Kardinal, Ch.; Loi, E.; Keegan, E.; Kristo, M.J.

2018-01-01

Seven laboratories used the results of bulk uranium isotopic analysis by either inductively coupled plasma mass spectrometry (ICP-MS) or thermal ionization mass spectrometry (TIMS) for characterization of the samples in the Nuclear Forensic International Technical Working Group fourth international collaborative material exercise, CMX-4. Comparison of the measured isotopic compositions of uranium in three exercise samples is implemented for identifying any differences or similarities between the samples. The role of isotopic analyses in the context of a real nuclear forensic investigation is discussed. Several limitations in carrying out ICP-MS or TIMS analysis in CMX-4 are noted. (author)

Direct determination of the samarium:neodymium ratio in geological materials by inductively coupled plasma quadrupole mass spectrometry with cryogenic desolvation. Comparison with isotope dilution thermal ionization mass spectrometry

International Nuclear Information System (INIS)

Pin, Christian; Telouk, Philippe; Imbert, J.-L.

1995-01-01

A cryogenic desolvation unit in the sample introduction system reduces differences in oxide formation between Sm and Nd to very low levels, enabling the direct, standardless determination of their ratio in bulk solutions by inductively coupled plasma mass spectrometry. The measured values are in reasonably good agreement with those determined by the isotope dilution thermal ionization mass spectrometry (ID-TIMS) reference technique. Although this method cannot, at present, compete with ID-TIMS in terms of precision and accuracy, it is much more straightforward and can be used in geochemistry for studies involving the screening of a large number of samples. (author)

Sovereignty and Collaboration: Affordable Strategies in Times of Austerity

Science.gov (United States)

2016-10-01

Contractor ...en t S S S % co st in cr ea se -0 .6 -1 .5 -1 .5 Eu ro fig ht er (T yp ho on ) 20 03 Es tim at e £ M 14 ,7 27 18 ,8 32 18 ,8 69 18 ,6 33 19 ,6 70...f p ro cu re m en t C O TS % co st in cr ea se -3 1 N ex t- ge ne ra tio n lig ht an ti- ar m ou r w ea po n 20 09 Es tim at e £ M 35 5 35 6

The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma

Directory of Open Access Journals (Sweden)

Nakamoto K

2018-02-01

Full Text Available Kenji Nakamoto,1 Masahiko Takeshi,2 Toshihiko Hiraoka,2,3 Mayuko Eguchi,2,4 Yuichiro Nakano,1,2 Naomi Otsuka,5 Hiroko Hizaki,5 Hiromi Akai,5 Masayo Hashimoto5 1Department of Ophthalmology, Nippon Medical School, Tokyo, Japan; 2Shinanozaka Clinic, Tokyo, Japan; 3Hiraoka Eye Clinic, Saitama, Japan; 4Musashiurawa Eye Clinic, Saitama, Japan; 5Japan Medical Affairs, Global R&D, Santen Pharmaceutical Co., Ltd., Osaka, Japan Objective: The aim of this study was to evaluate the 24-hour intraocular pressure (IOP-control effect of the tafluprost/timolol fixed combination (TAF/TIM-FC in patients with primary open-angle glaucoma after they switched from the concomitant use of tafluprost and timolol gel-forming solution. Patients and methods: Twenty patients with primary open-angle glaucoma (12 male and 8 female; mean ± SD age, 57.0±7.1 years were included in this study. The patients were treated for 8 weeks with the concomitant administration of tafluprost and timolol gel-forming solution (evening dosing. At the end of this period, the patients underwent 24-hour IOP monitoring (measured at 21:00, 01:00, 05:00, 09:00, 13:00 and 17:00. IOP was measured with Goldmann applanation tonometer (GAT and Icare PRO at sitting position at all timepoints and additionally, at supine position with Icare PRO tonometer at 01:00 and 05:00. The patients were then all switched to TAF/TIM-FC treatment (evening dosing. After 8 weeks, the 24-hour IOP monitoring was repeated. Results: Nineteen patients completed the study. The mean 24-hour IOPs in the concomitant and TAF/TIM-FC phases were 13.8±2.7 vs 13.3±2.8 mmHg (P=0.0033 with the GAT in the sitting position and 13.96±2.56 vs 13.48±2.56 mmHg (P=0.0120 with the Icare PRO in habitual positions. In comparison with the concomitant phase, significantly lower IOP was observed for the TAF/TIM-FC phase at 21:00 and 01:00 with the GAT and at 01:00 with the Icare PRO. In addition, the maximum IOP and fluctuations in IOP in

A 6-month study comparing efficacy, safety, and tolerability of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% versus each of its individual preservative-free components.

Science.gov (United States)

Pfeiffer, Norbert; Traverso, Carlo E; Lorenz, Katrin; Saarela, Ville; Liinamaa, Johanna; Uusitalo, Hannu; Astakhov, Yury; Boiko, Ernest; Ropo, Auli

2014-12-01

The efficacy, safety and tolerability of the preservative-free (PF) fixed combination (FC) of tafluprost 0.0015% and timolol 0.5% (once daily) were compared to those of the individual components (PF tafluprost 0.0015% once daily and PF timolol 0.5% twice daily) in patients with open-angle glaucoma or ocular hypertension inadequately controlled on prior timolol or prostaglandin monotherapy for 6 months. A stratified, double-masked, randomized, multicenter phase III study was conducted. A total of 189 prior timolol users were randomized within the timolol stratum (TS) to receive either FC (n = 95) or timolol 0.5% (TIM; n = 94). Furthermore, a total of 375 prior prostaglandin analog (PGA) users were randomized within the prostaglandin stratum (PS) to receive either FC (n = 188) or tafluprost 0.0015% (TAF; n = 187). To be eligible for participation in the study, the patients were required to have an intraocular pressure (IOP) of ≥22 mmHg when on timolol (TIM) or of ≥20 mmHg when on PGA in either treated eye at the screening and end-of-run-in visits. In addition to these, the study included visits at baseline, 2 and 6 weeks, 3 and 6 months and at a post-study visit. IOP was measured at 8 a.m., 10 a.m., 4 p.m., and 8 p.m. In the TS, a significant reduction from baseline IOP was seen with FC and TIM throughout the study. Average diurnal IOP change from baseline at month 3 was -8.55 mmHg (32%) for FC and -7.35 mmHg (28%) for TIM. The model-based treatment difference (FC-TIM) was -0.885 mmHg [95% confidence interval (CI) -1.745 to -0.024; p = 0.044] demonstrating the superiority of FC over TIM. In the PS, a significant reduction in IOP was seen with both FC and TAF throughout the study. The average diurnal IOP change from baseline at month 3 was -8.61 mmHg (33%) for FC and -7.23 mmHg (28%) for TAF. The model-based treatment difference (FC-TAF) was -1.516 mmHg (95% CI -2.044 to -0.988; p preservative-free fixed combination of tafluprost and

Negovalni tim in komunikacija v zdravstveni negi

OpenAIRE

Balažic, Ignac

2012-01-01

V magistrskem delu smo predstavili psihodinamične elemente komuniciranja posameznika in dinamiko negovalnega tima. Opisane so določene komunikacijske veščine, ki so potrebne za uspešno medsebojno sodelovanje. Namen je ugotoviti ali se medicinske sestre v psihiatrični zdravstveni negi zavedajo pomena komunikacije za profesionalno delo v zdravstveni negi. Prav tako je namen ugotoviti, kako medicinske sestre in zdravstveni tehniki ocenjujejo komunikacijo na oddelku. Raziskovalna metodologija...

Pengaruh Struktur Organisasi Terhadapkomunikasi dalam Tim Audit

OpenAIRE

Muhammad, Rifqi

2009-01-01

Some audit researchers suggest that high levels of audit team structure may encumber communication within audit teams by impeding information-gathering activities. Others suggest that structure benefits communication by coordinating controlling information flows. This study evaluated these arguments by examining the relationship between the structure of audit teams and selected communication variables (information overload, boundary spanning, satisfaction with supervision, and accuracy of inf...

Neural stem cell-derived exosomes mediate viral entry

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Sims B

2014-10-01

Full Text Available Brian Sims,1,2,* Linlin Gu,3,* Alexandre Krendelchtchikov,3 Qiana L Matthews3,4 1Division of Neonatology, Department of Pediatrics, 2Department of Cell, Developmental, and Integrative Biology, 3Division of Infectious Diseases, Department of Medicine, 4Center for AIDS Research, University of Alabama at Birmingham, Birmingham, AL, USA *These authors contributed equally to this work Background: Viruses enter host cells through interactions of viral ligands with cellular receptors. Viruses can also enter cells in a receptor-independent fashion. Mechanisms regarding the receptor-independent viral entry into cells have not been fully elucidated. Exosomal trafficking between cells may offer a mechanism by which viruses can enter cells.Methods: To investigate the role of exosomes on cellular viral entry, we employed neural stem cell-derived exosomes and adenovirus type 5 (Ad5 for the proof-of-principle study. Results: Exosomes significantly enhanced Ad5 entry in Coxsackie virus and adenovirus receptor (CAR-deficient cells, in which Ad5 only had very limited entry. The exosomes were shown to contain T-cell immunoglobulin mucin protein 4 (TIM-4, which binds phosphatidylserine. Treatment with anti-TIM-4 antibody significantly blocked the exosome-mediated Ad5 entry.Conclusion: Neural stem cell-derived exosomes mediated significant cellular entry of Ad5 in a receptor-independent fashion. This mediation may be hampered by an antibody specifically targeting TIM-4 on exosomes. This set of results will benefit further elucidation of virus/exosome pathways, which would contribute to reducing natural viral infection by developing therapeutic agents or vaccines. Keywords: neural stem cell-derived exosomes, adenovirus type 5, TIM-4, viral entry, phospholipids

Determination of natural and depleted uranium in urine at the ppt level: an interlaboratory analytical exercise

International Nuclear Information System (INIS)

D'Agostino, P.A.; Ough, E.A.; Glover, S.E.; Vallerand, A.L.

2002-10-01

An analytical exercise was initiated in order to determine those analytical procedures with the capacity to measure uranium isotope ratios ( 238 U/ 235 U) in urine samples containing less that 1μ uranium /L urine. A host laboratory was tasked with the preparation of six sets (12 samples per set) of synthetic urine samples spiked with varying amounts of natural and depleted (0.2% 235 U) uranium. The sets of samples contained total uranium in the range 25 ng U/L urine to 770 ng U/L urine, with isotope ratios ( 238 U/ 235 U) from 137.9 (natural uranium) to 215 (∼50% depleted uranium). Sets of samples were shipped to five testing laboratories (four Canadian and one European) for total and isotopic assay. The techniques employed in the analyses included sector field inductively coupled plasma mass spectrometry (ICP-SF-MS), quadrupole inductively coupled plasma mass spectrometry (ICP-Q-MS), thermal ionization mass spectrometry (TIMS) and neutron activation analysis (NAA). Full results were obtained from three testing labs (ICP-SF-MS, ICP-Q-MS and TIMS). Their results, plus partial results from the NAA lab, have been included in this report. Total uranium and isotope ratio results obtained from ICP-SF-MS and ICP-Q-MS were in good agreement with the host lab values. Neutron activation analysis and TIMS reported total uranium concentrations that differed from the host lab. An incomplete set of isotopic ratios was obtained from the NAA lab with some results reporting enriched uranium (% 235 U > 0.7). Based on the reported results, the four analytical procedures were ranked: ICP-SF-MS (1), ICP-Q-MS (2), TIMS (3) and NAA (4). (author)

Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2)

Energy Technology Data Exchange (ETDEWEB)

Torres-Escribano, Silvia [Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia (Spain); Denis, Sylvain; Blanquet-Diot, Stephanie [Clermont Universite, Universite d' Auvergne, Centre de Recherche en Nutrition Humaine Auvergne, ERT 18, Conception ingenierie et developpement de l' aliment et du medicament, BP 10448, F-63000 Clermont-Ferrand (France); Calatayud, Marta [Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia (Spain); Barrios, Laura [Departamento de Informatica Cientifica (SGAI-CSIC), C/ Pinar 19, 28006 Madrid (Spain); Velez, Dinoraz, E-mail: deni@iata.csic.es [Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia (Spain); Alric, Monique [Clermont Universite, Universite d' Auvergne, Centre de Recherche en Nutrition Humaine Auvergne, ERT 18, Conception ingenierie et developpement de l' aliment et du medicament, BP 10448, F-63000 Clermont-Ferrand (France); Montoro, Rosa [Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia (Spain)

2011-01-01

Bioaccessibility, the fraction of an element solubilized during gastrointestinal digestion and available for absorption, is a factor that should be considered when evaluating the health risk of contaminants from food. Static and dynamic models that mimic human physiological conditions have been used to evaluate bioaccessibility. This preliminary study compares the bioaccessibility of arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in two food certified reference materials (CRMs) (seaweed: Fucus sp., IAEA-140/TM; Lobster hepatopancreas: TORT-2), using two in vitro gastrointestinal digestion methods: a static method (SM) and a dynamic multicompartment method (TIM-1). There are significant differences (p < 0.05) between the bioaccessible values of As, Cd, Pb and Hg obtained by SM and TIM-1 in the two CRMs. The specific form in which the elements studied are present in the CRM may help to explain the bioaccessibility values obtained. - Research Highlights: {yields}Data are reported for As, Cd, Pb and Hg bioaccessibility from food CRMs. {yields}The static and TIM-1 methods give significantly different bioaccessibility values. {yields}The possible influence of speciation on bioaccessibility is discussed. {yields}To improve bioaccessibility quality data, food reference materials are needed.

Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2)

International Nuclear Information System (INIS)

Torres-Escribano, Silvia; Denis, Sylvain; Blanquet-Diot, Stephanie; Calatayud, Marta; Barrios, Laura; Velez, Dinoraz; Alric, Monique; Montoro, Rosa

2011-01-01

Bioaccessibility, the fraction of an element solubilized during gastrointestinal digestion and available for absorption, is a factor that should be considered when evaluating the health risk of contaminants from food. Static and dynamic models that mimic human physiological conditions have been used to evaluate bioaccessibility. This preliminary study compares the bioaccessibility of arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in two food certified reference materials (CRMs) (seaweed: Fucus sp., IAEA-140/TM; Lobster hepatopancreas: TORT-2), using two in vitro gastrointestinal digestion methods: a static method (SM) and a dynamic multicompartment method (TIM-1). There are significant differences (p < 0.05) between the bioaccessible values of As, Cd, Pb and Hg obtained by SM and TIM-1 in the two CRMs. The specific form in which the elements studied are present in the CRM may help to explain the bioaccessibility values obtained. - Research Highlights: →Data are reported for As, Cd, Pb and Hg bioaccessibility from food CRMs. →The static and TIM-1 methods give significantly different bioaccessibility values. →The possible influence of speciation on bioaccessibility is discussed. →To improve bioaccessibility quality data, food reference materials are needed.

Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system.

Science.gov (United States)

Brouwers, Joachim; Anneveld, Bart; Goudappel, Gert-Jan; Duchateau, Guus; Annaert, Pieter; Augustijns, Patrick; Zeijdner, Evelijn

2011-02-01

In the present study, we demonstrated the value of two advanced tools, the TNO gastric and small Intestinal Model (TIM-1) and magnetic resonance imaging (MRI), for the in vitro evaluation of food-dependent disintegration of immediate release fosamprenavir tablets. Upon introduction of a tablet with the nutritional drink Scandishake Mix® in the stomach compartment of TIM-1, simulating the fed state, disintegration and fosamprenavir dissolution were significantly postponed compared to the fasted state (lag time 80 ± 23 min). This resulted in a lag in the appearance of bioaccessible fosamprenavir (tablet disintegration and subsequent amprenavir absorption in healthy volunteers. Therefore, TIM-1 can be used in tablet development to identify food-induced disintegration issues causing unexpected clinical behavior. From a mechanistic perspective, we applied MRI to illustrate impaired water ingress in fosamprenavir tablets immersed in the nutritional drink compared to simulated gastric fluid. This effect may be attributed to both competition between nutritional components and the tablet for the available water (indicated by reduced rotational and translational diffusion) as well as the possible formation of a food-dependent precipitation layer on the HPMC-coated tablet. Copyright © 2010 Elsevier B.V. All rights reserved.

The UKIRT Upgrades Programme

Science.gov (United States)

Adamson, Andy; Davies, John; Robson, Ian

Tim Hawarden presented this paper to the 30th anniversary workshop, just a month before his untimely death. The editors have done their best to convert his talk into this paper, and gratefully acknowledge the assistance of Nick Rees (a member of the Upgrades team, now at Diamond Light Source). Tim's discussion concerned the UKIRT Upgrades Project, which ran through the 1990s and transformed the telescope and made it truly competitive on the world stage for operation into the twenty-first century. The reference list at the end of the paper is comprehensive; some of these are referred to in the paper itself and some are included for completeness only.

The Historiography of Islamic Law: The Case of Tārīkh al-Tashrī‘ Literature

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Arif Maftuhin

2016-12-01

Full Text Available Tārīkh al-Tashrī‘ (the history of sharia affairs is a relatively new genre of Islamic historiography and very popular among students of Islamic Law. Despite its popularity, academics of Islamic historiography seem not interested in studying it. There is hardly any academic paper seriously studied the literature. This paper is a first effort to explore the Tārīkhu’t-tashrī‘ literature through a historiographical analysis. As an initial exploration, it argues that Tārīkh al-Tashrī‘ is the latest development of Islamic historiography, developed in the 19th century, but it is a genre of the old Islamic historiography with some new elements. The new elements are influenced by both modern Western historiography and the need to re-open the supposedly closed gate of ijtihād. The paper studied books of Tārīkh al-Tashrī‘ available during the research between 2013-2015. [Tārīkh al-Tashrī‘ adalah genre yang relatif ‘baru’ dalam matarantai perkembangan historiografi Islam­. Literatur ini sangat popular dan menjadi mata kuliah wajib di fakultas-fakultas Syariah di Indonesia maupun Timur Tengah. Hanya saja, meskipun ia sangat populer sebagai mata pelajaran, Tārīkh al-Tashrī‘ belum banyak menarik minat para peneliti historiografi. Makalah in berusaha mengeksplorasi literatur Tārīkh al-Tashrī‘ dengan pendekatan historiografi. Makalah ini berpendapat bahwa Tārīkh al-Tashrī‘, meski terlihat ‘modern’ dari segi kelahirannya, tidak banyak berbeda dengan literatur historiografi klasik. Perbedaan terjadi karena adanya pengaruh historiografi Barat dalam model penulisannya dan karena kebutuhan untuk membuka kembali pintu ijtihad yang tertutup. Kajian dilakukan terhadap kitab-kitab Tārīkh al-Tashrī‘ yang dapat ditemukan selama riset antara 2013-2015 

Reducing public communication apprehension by boosting self confidence on communication competence

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Eva Rachmi

2012-07-01

Full Text Available Abstrak Latar belakang: Dokter harus kompeten dalam berkomunikasi dengan sesame dokter ata dengan profesi lain. Pada Fakultas Kedokteran Universitas Mulawarman, beberapa mahasiswa cenderung diam pada saat pelatihan komunikasi public, yang tampaknya disebabkan oleh kecemasan saat berkomunikasi. Penelitian ini bertujuan untuk menganalisa kemungkinan ‘kepercayaan diri terhadap kemampuan komunikasi’ dan  ‘ketrampilan berkomunikasi’ sebagai factor resiko terjadinya ‘kecemasan dalam komunikasi publik’ Metode: Penelitian ini dilakukan pada 55 mahasiswa Fakultas Kedokteran Universitas Mulawarman. Kecemasan dalam komunikasi public diukur dengan Personal report of communication apprehension (PRCA-24, kepercayaan diri terhadap kemampuan komunikasi dengan Self perceived communication competence scale (SPCC, ketrampilan berkomunikasi didasarkan pada penilaian instruktur saat program pelatihan komunikasi, Data dianaliasa dengan regresi linear untuk mengidentifikasi factor yang dominan, menggunakan STATA 9.0 Hasil: Hasil penelitian menunjukkan hubungan negative antara kecemasan dalam public komunikasi dengan kepercayaan diri terhadap kemampuan komunikasi (koefisien regresi (KR =-0.13; p=0.000; 95% derajat kepercayaan (DK =-0.20; -0.52. Tetapi, terbukti tidak berhubungan dengan ketrampilan komunikasi (p=0.936. Diantara 12 trait kepercayaan diri terhadap kemampuan komunikasi, mahasiswa yang percaya diri saat berkomunikasi dengan sekelompok orang yang masih asing mempunyai tingkat kecemasan paling rendah (KR suaian=-0.13; DK=-0.21; 0.05; p=0.002. Kesimpulan: Semakin tinggi kepercayaan diri mahasiswa terhadap kemampuan komunikasinya akan semakin rendah tingkat kecemasannya. Untuk itu, fakulta kedokteran perlu memberikan kesempatan bagi mahasiswa mempraktekkan komunikasi public, terutama dengan berbicara kepada sekelompok orang asing. (Health Science Indones 2010; 1: 37 - 42 Kata kunci: berbicara, kelompok, kemampuan komunikasi ABSTRACT Background: A

PROCEDIMIENTO DE EVALUACIÓN Y MEJORA DE LA GESTIÓN DE LA INNOVACIÓN EN LA HOTELERÍA / PROCEDURE FOR THE EVALUATION AND IMPROVEMENT OF INNOVATION MANAGMENT IN THE HOTEL INDUSTRY

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Bisleivys Jiménez-Valero

2012-01-01

Full Text Available La práctica internacional en la Gestión de la Tecnología y la Innovación (GTI y la situación de las entidades hoteleras estudiadas, alrededor de la ciencia y la tecnología, permiten identificar carencia de procedimientos para la evaluación de la GTI. De manera que el objetivo del presente trabajo consiste en crear un procedimiento de evaluación y mejora de la Gestión de la Tecnología y la Innovación para entidades hoteleras con modalidad Todo Incluido, que contribuya al perfeccionamiento de su gestión y a la mejora del desempeño de los procesos. Los resultados fundamentales se centran en el desarrollo de un procedimiento general, apoyado en procedimientos específicos para: la obtención de las dimensiones y los indicadores para la evaluación de la GTI, el cálculo de los indicadores y del índice integral de GTI, así como el diseño y la implementación de propuestas de mejora.The international practice in Technology and Innovation Management (TIM and the situation of the studied hotel organizations, about science and technology, provide the possibility of identifying the lack of procedures to evaluate the TIM, so, the objective of this paper is to create a procedure of evaluation and an improvement of the Technology and Innovation Management for hotel organizations with all included modality, which contributes to the improvement of its management and development of their processes. The main results are focused on the development of a general procedure, supported by specific procedures for: obtaining dimensions and markers to evaluate the TIM, calculating the markers and integral index of the TIM, designing and implementing improvement proposals.

A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.

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Varun ePandey

2013-09-01

Full Text Available Pantothenate Kinase-Associated Neurodegeneration (PKAN is a neurodegenerative disorder with a poorly understood molecular mechanism. It is caused by mutations in Pantothenate Kinase, the first enzyme in the Coenzyme A (CoA biosynthetic pathway. Here, we developed a Drosophila model of PKAN (tim-fbl flies that allows us to continuously monitor the modeled disease in the brain. In tim-fbl flies, downregulation of fumble, the Drosophila PanK homologue in the cells containing a circadian clock results in characteristic features of PKAN such as developmental lethality, hypersensitivity to oxidative stress, and diminished life span. Despite quasi-normal circadian transcriptional rhythms, tim-fbl flies display brain-specific aberrant circadian locomotor rhythms, and a unique transcriptional signature. Comparison with expression data from flies exposed to paraquat demonstrates that, as previously suggested, pathways others than oxidative stress are affected by PANK downregulation. Surprisingly we found a significant decrease in the expression of key components of the photoreceptor recycling pathways, which could lead to retinal degeneration, a hallmark of PKAN. Importantly, these defects are not accompanied by changes in structural components in eye genes suggesting that changes in gene expression in the eye precede and may cause the retinal degeneration. Indeed tim-fbl flies have diminished response to light transitions, and their altered day/night patterns of activity demonstrates defects in light perception. This suggest that retinal lesions are not solely due to oxidative stress and demonstrates a role for the transcriptional response to CoA deficiency underlying the defects observed in dPanK deficient flies. Moreover, in the present study we developed a new fly model that can be applied to other diseases and that allows the assessment of neurodegeneration in the brains of living flies.

The trace ion module for the Monte Carlo code Eirene, a unified approach to plasma chemistry in the ITER divertor

International Nuclear Information System (INIS)

Seebacher, J.; Reiter, D.; Borner, P.

2007-01-01

Modelling of kinetic transport effects in magnetic fusion devices is of great importance for understanding the physical processes in both the core and and the scrape off layer (SOL) plasma. For SOL simulation the EIRENE code is a well established tool for modelling of neutral, impurities and radiation transport. Recently a new trace ion transport module (tim), has been developed and incorporated into EIRENE. The tim essentially consists of two parts: 1) A trajectory integrator tracing the deterministic motion of a guiding centre particle in general 3D electric and magnetic fields. 2) A stochastic representation of the Fokker Planck collision operator in suitable guiding centre coordinates treating Coulomb collisions with the plasma background species. The TIM enables integrated SOL simulation packages such as B2-EIRENE, EDGE2D-EIRENE (2D) or EMC3-EIRENE (3D) to treat the physical and chemical processes near the divertor targets and in the bulk of the SOL in greater detail than before, and in particular on a kinetic rather than a fluid level. One of the physics applications is the formation and transport of hydrocarbon molecules and ions in the divertor in tokamaks, where the tritium co deposition via hydrocarbons remains a serious issue for next generation fusion devices like ITER. Real tokamak modelling scenarios will be discussed with the code packages B2-EIRENE (2D) and EMC3-EIRENE (3D). A brief overview of the theoretical basis of the tim will be given including code verification studies of the basic physics properties. Applications to hydrocarbon transport studies in TEXTOR and ITER, comparing present (fluid) approximations in edge modelling with the new extended kinetic model, will be presented. (Author)

New Literature on Law and Political Institutions in Indonesia

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Karolina Prasad

2012-01-01

Full Text Available Reviews of new literature: Butt, Simon, and Tim Lindsey (2012, The Constitution of Indonesia: A Contextual Analysis Oxford: Hart Publishing (Constitutional Systems of the World Series, ISBN-13: 978-1849460187, 292 pages || Kimura, Ehito (2012, Political Change and Territoriality in Indonesia: Provincial Proliferation London: Routledge (Routledge Contemporary Southeast Asia Series, ISBN 9781136301810, 171 pages || Lindsey, Tim (2012, Islam, Law and the State in Southeast Asia: Volume I: Indonesia London – New York: Tauris I. B. (Islam, Law and the State in Southeast Asia Series, ISBN-13: 978-1848850651, 565 pages || Lukito, Ratno (2012, Legal Pluralism in Indonesia: Bridging the Unbridgeable London: Routledge (= Routledge Contemporary Southeast Asia Series 48, ISBN 9780415673426, 288 pages

Plasticity of TOM complex assembly in skeletal muscle mitochondria in response to chronic contractile activity.

Science.gov (United States)

Joseph, Anna-Maria; Hood, David A

2012-03-01

We investigated the assembly of the TOM complex within skeletal muscle under conditions of chronic contractile activity-induced mitochondrial biogenesis. Tom40 import into mitochondria was increased by chronic contractile activity, as was its time-dependent assembly into the TOM complex. These changes coincided with contractile activity-induced augmentations in the expression of key protein import machinery components Tim17, Tim23, and Tom22, as well as the cytosolic chaperone Hsp90. These data indicate the adaptability of the TOM protein import complex and suggest a regulatory role for the assembly of this complex in exercise-induced mitochondrial biogenesis. Copyright © 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved. All rights reserved.

Polychronous Zirconology of Navysh Volcanics of the Ai Formation (Southern Urals)

Science.gov (United States)

Krasnobaev, A. A.; Puchkov, V. N.; Sergeeva, N. D.

2018-01-01

In order to resolve the age of Navysh volcanics (NV), which is usually attributed to the Lower Riphean of the Ai Formation, we have used geochronological, petrologic, and mineralogical methods of zirconology, apart from the SHRIMP isotopic data of single zircon grains. Moreover, TIMS isotope age analyses have been conducted, the results of which can be regarded as both controlling and providing the most correct information. The TIMS and SHRIMP data make it possible to suggest a polychronous character of the NV, which include not only Riphean, but also Paleozoic groups of volcanics. In this situation, an assessment of the scales of such polychroneity of NV and, correspondingly, of the Ai Formation as a whole becomes urgent.

The Multiverse and Divine Creation

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Michael Almeida

2017-11-01

Full Text Available I provide the account of divine creation found in multiverse theorists Donald Turner, Klaas Kraay, and Tim O’Connor. I show that the accounts Kraay and Turner offer are incoherent. God does not survey all possible worlds and necessarily actualize those universes in the (on balance good worlds or the worthy worlds. If God necessarily actualizes the multiverse, we have no idea which universes are parts of that multiverse. I show next that Tim O’Connor’s multiverse account of creation is also incoherent. I argue that a preferable multiverse would include a much greater variety of universes than are included in Turner, Kraay or O’Connor. In the last section I offer some concluding remarks.

Penggunaan E-learning Ilmo untuk Meningkatkan Mutu Perkuliahan di Fakultas Ekonomi

OpenAIRE

Asrori, Asrori; Fachrurrozie, Fachrurrozie

2011-01-01

This study has objectives to examine empirically the behavior of teachers in accepting the use of e-Learning Ilmo (Learning Increasing Motivation) and ti improve the quality of lectures at Economic Faculty. The respondents of this research were lectures who were the users of e-Learning Ilmo. The data were collected through qustionnaire that was developed based on the construct of the theory of technology acceptance (Davis et al, 1989). The results of hypotheses testing were: (1) The usefulnes...

Pengembangan Teknologi Informasi Mobile Learning Fakultas Teknik Universitas Diponegoro Berbasis Android

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Resi Jiwa Kasatria

2014-11-01

Full Text Available Perkembangan teknologi mobile seluler sudah sedemikian cepat dan dapat dirasakan di seluruh dunia dan dimanfaatkan dalam berbagai bidang kehidupan. Perkembangan ini dapat pula dilakukan dalam dunia pendidikan dan memungkinkan terobosan baru dalam belajar secara mobile menggunakan perangkat teknologi informasi (handphone atau disebut mobile learning (m-learning. M-learning memiliki beberapa kelebihan di antaranya adalah independensi dalam pembelajaran. Namun, di sisi lain, perangkat pembelajaran m-learning memiliki keterbatasan sumber daya dan keragaman platform sehingga diperlukan rancangan yang mampu menjamin kompatibilitas. Aplikasi Mobile Learning ini dikembangkan menggunakan Java EE untuk menangani servernya dan untuk sisi klien menggunakan Bootstrap mobile. Basis data yang digunakan adalah MySQL. Aplikasi ini akan mempunyai 3 role pengguna yaitu admin yang akan menangani penambahan user dan pengelolaan mata kuliah, dosen yang akan memberikan materi, tugas dan kuis dan mahasiswa yang dapat melihat materi, tugas dan kuis yang diberikan dosen. Mobile Learning ini dapat membantu dosen dan mahasiswa dalam melakukan interaksi dalam berbagi materi, dalam pemberian tugas dan mengerjakan kuis. Mahasiswa maupun dosen tidak lagi harus bertatap muka, yang diperlukan hanyalah koneksi internet untuk melakukan proses belajar mengajar. Selain itu Mobile Learning ini juga dapat berjalan dengan baik saat diuji pada 3 buah versi android yang berbeda yaitu versi 2.3, versi 4.0 dan versi 4.2.

STUDI PENELUSURAN LULUSAN S1 KEPENDIDIKAN FAKULTAS TEKNIK UNIVERSITAS NEGERI YOGYAKARTA

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Thomas Sukardi

2015-02-01

Full Text Available ABSTRACT This research aim at revealing: (1 graduate absorption from bachelor of education Faculty of Engineering, Yogyakarta State University (YSU in job market, (2 information of suitability of competence and job oppportunity, (3 feedback from graduates’ employer/ user, (4 opinion form the alumnae. This study can be catagorized as survey research which was conducted in September till November  2010. The research population was the graduates from the year of 2006 to 2012 and this study employed snowball technique as  data collection technique. The instrument of data collection were using open and closed questionnaire with online or offline process. The online procedure was through website of  http://ft.uny.ac.id/tracer, email of tracerftuny@gmail.com while the offline one was through sending letter. The qualitative data were analyzed by crosstab and percentage and the qualitative one was using categorial analysis.   The findings showed that (1 the graduates’absorption can be catagorized as good catagory, the waiting period for the graduates to get a job was less than 3 months with percentage of 52.8%, for period of 3-6 months was 23.1%, more than 12 months was 7.2% and not giving answer was 5.6%; (2 the students’ competence also catagorized as good catagory, but for supporting aspects such as managerial and leadership aspect still needed to be improved; (3 the feedback from graduates’ employers or users were in case of improving managerial ability, leadership aspect, foreign language competence, information technology skills, and soft skills (4 the suggestions from alumnae or the graduates of Faculty of Engineering YSU in order to develop graduates competence on education field were the separation between students community service and teaching practicum though it took in the same location of school,  enhancing the guidence process with the  lecturers such for scientific writing, enhancing the experience of teaching on the real context especially for the students with educational background, enhancing learning based multimedia, developing the curriculum which was suited with Vocational High School, and the teaching methodology also needed to be reviewed and improved. Keywords: bachelor of education, graduates absorption and graduates’tracer study

Evaluasi Peraturan Pelayanan Perpustakaan di Perpustakaan Fakultas Ekonomika dan Bisnis UGM

Directory of Open Access Journals (Sweden)

Maryatun Maryatun

2016-09-01

Full Text Available Purpose –The purpose of this study was to identify the reasons for due date book returns, borrowers' attitude when exposed to fines, library efforts to minimize fines and evaluate the effectiveness of fines in the library. Design/methodology/approach – This study used descriptive quantitative and qualitative approach. It was conducted at the Library of the Faculty of Economics and Business, Universitas Gadjah Mada. Samples were purposively selected, involving undergraduate and postgraduate students batch 2011, 2012 and 2013 that never got fines and were still active. Findings – Borrowers had some reasons for overdue book returns, such as they forgot renewing the book, the book was booked by another user, they forgot the due date, they had no class to attend, had not finished reading, borrowed in short period of time, as well as other reasons, such as illness, a friend borrowed the book. So the term of the loan for 5 days was considered insufficient for them to read the books. Borrowers had to pay fines directly. If they were not yet able to pay the fines then they would not borrow books. Borrowers knew that overdue books would put other users at a disadvantage. Most of borrowers considered the fine to pay as much as Rp5,000.00 /day/book was high. But a few regarded it low. Borrowers considered that blocking the system was not effective for those who were late paying fines. The most effective effort that could be done in order that the borrower returned the books on time was providing online renewal system.

KINERJA UNIT DALAM MENDUKUNG PENGEMBANGAN FAKULTAS ILMU ADMINISTRASI UNIVERSITAS LANCANG KUNING

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Prihati Prihati

2018-02-01

Full Text Available Performance Faculty of Administrative Sciences can be seen from the performance of employees. This study focuses on the performance of existing units in the Faculty of Administration in carrying out its main duties and functions in order to support the strengthening of Faculty's performance. But in reality the performance of existing units in the faculty of administration of the University of Lancang Kuning showed less satisfactory work. Indicators that are visible include unstructured unit work programs, inadequate facilities and infrastructure, limited budget support and weak leadership which are a constraint in motivating employees to do their job well. The objective of the study was to explain the performance of faculty units and their inhibiting factors. The research method uses qualitative with emphasis on the concept of performance measurement. The techniques used in data collection are observation, interview and documentation study. The results showed that the performance of the faculty unit has not run well, this is obtained from the measurement of performance indicators that include job performance, expertise, behavior and leadership. As for the inhibiting factors of faculty unit performance is the limited support of facilities, infrastructure and funding. Besides, the reward and punishment system has not been done to the employee job resulting in the employee's motivation in working to be reduced, besides it is necessary to be given guidance and training for the work unit to understand the duty and function properly.

Plaadid / Jüri F. Lotman

Index Scriptorium Estoniae

Lotman, Jüri F.

2004-01-01

Uutest heliplaatidest Dimitri from Paris "Cruising Attitude", Tim Hecker "Mirages", Ludacris "The Red Light District", Mario Frangoulis "Follow Your Heart", Loits "Vere kutse kohustab", "Flamenco Chill Sessions"

Isotope Dilution - Thermal Ionisation Mass Spectrometric Analysis for Tin in a Fly Ash Material; Analisis de Estano en una Ceniza de Combustion mediante Espectrometria de Masas de Ionizacion Termica con Dilucion Isotopica

Energy Technology Data Exchange (ETDEWEB)

Hernandez, C; Fernandez, M; Quejido, A L

2006-07-01

Isotope dilution-thermal ionisation mass spectrometry (ID-TIMS) analysis has been applied to the determination of tin in a fly ash sample supplied by the EC Joint Research Centre (Ispra, Italy). The proposed procedure includes the silica gel/phosphoric acid technique for tin thermal ionisation activation and a strict heating protocol for isotope ratio measurements. Instrumental mass discrimination factor has been previously determined measuring a natural tin standard solution. Spike solutions has been prepared from 112Sn-enriched metal and quantified by reverse isotope dilution analysis. Two sample aliquots were spiked and tin was extracted with 4,5 M HCI during 25 min ultrasound exposure time. Due to the complex matrix of this fly ash material, a two-step purification stage using ion-exchange chromatography was required prior TIMS analysis. Obtained results for the two sample-spike blends (10,10 + - 0,55 y 10,50 + - 0,64 imolg-1) are comprarable, both value and uncertainty. Also a good reproducibility is observed between measurements. The proposed ID-TIMS procedure, as a primary method and due to the lack of fly ash reference material certified for tin content, can be used to validate more routine methodologies applied to tin determination in this kind of materials. (Author) 75 refs.

Isolation of bifidobacteria for blood group secretor status targeted personalised nutrition

Directory of Open Access Journals (Sweden)

Harri Mäkivuokko

2012-06-01

Full Text Available Background: Currently, there is a constant need to find microbial products for maintaining or even improving host microbiota balance that could be targeted to a selected consumer group. Blood group secretor status, determining the ABO status, could be used to stratify the consumer group. Objective: We have applied a validated upper intestinal tract model (TIM-1 and culturing methods to screen potential probiotic bacteria from faeces of blood secretor and non-secretor individuals. Design: Faecal samples from healthy volunteers were pooled to age- and sex-matched secretor and non-secretor pools. Faecal pools were run through separate TIM-1 simulations, and bacteria were cultivated from samples taken at different stages of simulations for characterisation. Results: Microbes in secretor pool survived the transit through TIM-1 system better than microbes of non-secretor pool, especially bifidobacteria and anaerobes were highly affected. The differences in numbers of bifidobacteria and lactobacilli isolates after plate cultivations and further the number of distinct RAPD-genotypes was clearly lower in non-secretor pool than in secretor pool. Conclusions: In the present study, we showed that microbiota of secretor and non-secretor individuals tolerate gastrointestinal conditions differently and that a combination of gastrointestinal simulations and cultivation methods proved to be a promising tool for isolating potentially probiotic bacteria.

Improved analytical sensitivity for uranium and plutonium in environmental samples: Cavity ion source thermal ionization mass spectrometry

International Nuclear Information System (INIS)

Ingeneri, Kristofer; Riciputi, L.

2001-01-01

Following successful field trials, environmental sampling has played a central role as a routine part of safeguards inspections since early 1996 to verify declared and to detect undeclared activity. The environmental sampling program has brought a new series of analytical challenges, and driven a need for advances in verification technology. Environmental swipe samples are often extremely low in concentration of analyte (ng level or lower), yet the need to analyze these samples accurately and precisely is vital, particularly for the detection of undeclared nuclear activities. Thermal ionization mass spectrometry (TIMS) is the standard method of determining isotope ratios of uranium and plutonium in the environmental sampling program. TIMS analysis typically employs 1-3 filaments to vaporize and ionize the sample, and the ions are mass separated and analyzed using magnetic sector instruments due to their high mass resolution and high ion transmission. However, the ionization efficiency (the ratio of material present to material actually detected) of uranium using a standard TIMS instrument is low (0.2%), even under the best conditions. Increasing ionization efficiency by even a small amount would have a dramatic impact for safeguards applications, allowing both improvements in analytical precision and a significant decrease in the amount of uranium and plutonium required for analysis, increasing the sensitivity of environmental sampling

Isotope Dilution - Thermal Ionisation Mass Spectrometric Analysis for Tin in a Fly Ash Material

International Nuclear Information System (INIS)

Hernandez, C.; Fernandez, M.; Quejido, A. L.

2006-01-01

Isotope dilution-thermal ionisation mass spectrometry (ID-TIMS) analysis has been applied to the determination of tin in a fly ash sample supplied by the EC Joint Research Centre (Ispra, Italy). The proposed procedure includes the silica gel/phosphoric acid technique for tin thermal ionisation activation and a strict heating protocol for isotope ratio measurements. Instrumental mass discrimination factor has been previously determined measuring a natural tin standard solution. Spike solutions has been prepared from 112Sn-enriched metal and quantified by reverse isotope dilution analysis. Two sample aliquots were spiked and tin was extracted with 4,5 M HCI during 25 min ultrasound esposure time. Due to the complex matrix of this fly ash material, a two-steps purification stage using ion-exchange chromatography was required prior TIMS analysis. Obtained results for the two sample-spike blends (10,10 + - 0,55 y 10,50 + - 0,64 imolg-1) are comprarable, both value and uncertainty. Also a good reproducibility is observed between measurements. The proposed ID-TIMS procedure, as a primary method and due to the lack of fly ash reference material certified for tin content, can be used to validate more routine methodologies applied to tin determination in this kind of materials. (Author) 75 refs

Circadian Activators Are Expressed Days before They Initiate Clock Function in Late Pacemaker Neurons from Drosophila.

Science.gov (United States)

Liu, Tianxin; Mahesh, Guruswamy; Houl, Jerry H; Hardin, Paul E

2015-06-03

Circadian pacemaker neurons in the Drosophila brain control daily rhythms in locomotor activity. These pacemaker neurons can be subdivided into early or late groups depending on whether rhythms in period (per) and timeless (tim) expression are initiated at the first instar (L1) larval stage or during metamorphosis, respectively. Because CLOCK-CYCLE (CLK-CYC) heterodimers initiate circadian oscillator function by activating per and tim transcription, a Clk-GFP transgene was used to mark when late pacemaker neurons begin to develop. We were surprised to see that CLK-GFP was already expressed in four of five clusters of late pacemaker neurons during the third instar (L3) larval stage. CLK-GFP is only detected in postmitotic neurons from L3 larvae, suggesting that these four late pacemaker neuron clusters are formed before the L3 larval stage. A GFP-cyc transgene was used to show that CYC, like CLK, is also expressed exclusively in pacemaker neurons from L3 larval brains, demonstrating that CLK-CYC is not sufficient to activate per and tim in late pacemaker neurons at the L3 larval stage. These results suggest that most late pacemaker neurons develop days before novel factors activate circadian oscillator function during metamorphosis. Copyright © 2015 the authors 0270-6474/15/358662-10$15.00/0.

A comprehensive review of plants and their active constituents with wound healing activity in traditional Iranian medicine.

Science.gov (United States)

Hosein Farzaei, Mohammad; Abbasabadi, Zahra; Reza Shams-Ardekani, Mohammad; Abdollahi, Mohammad; Rahimi, Roja

2014-07-01

Wound healing is a complex cascade of events with various cellular and biochemical processes that result in reconstruction and regeneration of damaged tissue. The objective of the current study was to scientifically evaluate the medicinal plants said to produce wound healing activity in traditional Iranian medicine (TIM). Electronic databases were searched for the names of medicinal plants claimed in TIM literature for having wound healing activity. Articles were evaluated to obtain any in vitro, animal, or clinical evidence of their efficacy and possible mechanisms involved in would healing. Mechanisms of action for some of these plants, including Tamarix spp., Rosa spp., Piper betle, Plantago major, Oxalis spp., Olea europaea, Malva spp., Linum usitatissimum, and Tamarindus indica, have not been yet clarified. In contrast, some herbs such as Vitis vinifera, Quercus spp., Punica granatum, Pinus spp., Polygonum spp., Lilium spp., Gentiana lutea, Arnebia euchroma, Aloe spp., and Caesalpinia spp. have various biological and pharmacological mechanisms that have been verified for wound healing activity. Overall, TIM resources have introduced various medicinal plants for wounds with confirmed effectiveness according to current pharmacological studies. These herbal remedies could be considered as future drugs for healing of wounds. Further pharmacological and clinical investigations are recommended for exploring safety, exact mechanisms, and efficacy of these herbal remedies. .

Aircraft scanner data availability via the version 0 Information Management System

Science.gov (United States)

Mah, G. R.

1995-01-01

As part of the Earth Observing System Data and Information System (EOSDIS) development, NASA and other government agencies have developed an operational prototype of the Information Management System (IMS). The IMS provides access to the data archived at the Distributed Active Archive Centers (DAAC's) that allows users to search through metadata describing the (image) data. Criteria based on sensor name or type, date and time, and geographic location are used to search the archive. Graphical representations of coverage and browse images are available to further refine a user's selection. previously, the EROS Data Center (EDC) DAAC had identified the Advanced SOlid-state Array Spectrometer (ASAS), Airborne Visible and infrared Imaging Spectrometer (AVIRIS), NS-001, and Thermal Infrared Multispectral Scanner (TIMS) as precursor data sets similar to those the DAAC will handle in the Earth Observing System era. Currently, the EDC DAAC staff, in cooperation with NASA, has transcribed TIMS, NS-001, and Thematic Mapper Simulation (TMS) data from Ames Research Center and also TIMS data from Stennis Space Center. During the transcription process, the IMS metadata and browse images were created to populate the inventory at the EDC DAAC. These data sets are now available in the IMS and may be requested from the any of the DAAC's via the IMS.

Peran Unit Pelaksana Teknis (Upt) Industri Kulit Dan Produk Kulit Magetan Dalam Pemberdayaan Penyamak Kulit Di Kabupaten Magetan

OpenAIRE

purwanto, sofia rizky; astuti, puji; astrika, lusia

2016-01-01

Tanning industry is one of the regional potential in Magetan which has existed since the end of the Diponegoro War (± 1830), the tanning industry have helped support the leather industry. But in the years 1960-1970 the tanning industry has declined and nearly died because they were unable to compete with the plastics industry. To cope the situation the Local Government Magetan . UPT Industry Leather and Leather Products Magetan aims to build through the empowerment to the tanners, either thro...

Gambaran Komunikasi Interpersonal Perawat Pelaksana Menurut Persepsi Perawat dan Klien di Ruang Rawat Inap RSUD Dr. Pirngadi Medan

OpenAIRE

Harahap, Dini Angriani

2015-01-01

Communication is a means to develop the relationship between nurses and clients. It is very important effective in facilitating nurses to carry out the role and function properly. Interpersonal communication is a communication between two or more people in direct contact like a conversation. This kind of communication is done face to face with two way method or reciprocal, either verbal or non-verbal. The research used descriptive design which was aimed to find out the description of interper...