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Sample records for therapy feasibility study

  1. Training Endogenous Task Shifting Using Music Therapy: A Feasibility Study.

    Science.gov (United States)

    Lynch, Colleen; LaGasse, A Blythe

    2016-01-01

    People with acquired brain injury (ABI) are highly susceptible to disturbances in executive functioning (EF), and these effects are pervasive. Research studies using music therapy for cognitive improvement in this population are limited. The purpose of this study was to determine the feasibility of a Musical Executive Function Training (MEFT) intervention to address task-shifting skills in adults with ABI and to obtain preliminary evidence of intervention effect on task shifting. Fourteen participants were randomly assigned to one of three groups: a music therapy intervention group (MTG), a singing group (SG), or the no-intervention control group (CG). The SG and MTG met for one hour a day for five days. Feasibility measures included participant completion rates and intervention fidelity. Potential benefits were measured using the Trail Making Test and the Paced Auditory Serial Addition Task as a pre- and posttest measure. Participant completion rates and interventionist fidelity to the protocol supported feasibility. One-way ANOVA of the pre- and posttest group differences revealed a trend toward improvement in the MTG over the SG. Feasibility and effect size data support a larger trial of the MEFT protocol. © the American Music Therapy Association 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. Withdrawal of antihypertensive therapy in people with dementia: feasibility study.

    Science.gov (United States)

    van der Wardt, Veronika; Burton, Jennifer K; Conroy, Simon; Welsh, Tomas; Logan, Pip; Taggar, Jaspal; Tanajewski, Lukasz; Gladman, John

    2018-01-01

    This study explored the feasibility of a randomised controlled withdrawal trial of antihypertensive medication in normotensive people with dementia. Feasibility aspects included response, recruitment, exclusion and drop-out rates, suitability of outcome measures, acceptability of study procedures and an indicative economic evaluation for a randomised controlled trial. A cohort study attempting the withdrawal of antihypertensive drugs where appropriate and a feasibility study of home-based blood pressure monitoring, in people with dementia treated for hypertension, was undertaken. Interviews with participants and carers and an indicative economic evaluation were also undertaken. Three hundred and sixty-two primary care practices in the East Midlands were contacted of which only 41 (11% (95%CI 8-15%)) agreed to support the study. These 41 practices posted 940 letters to potential participants. Thirty participants were enrolled in the cohort study of whom 9 were eligible for the antihypertensive withdrawal programme, 20 participated in a home blood pressure monitoring sub-group analysis and 12 took part in an interview study. Twenty-two of those enrolled in the cohort study were followed up at 6 months. The withdrawal programme was acceptable to participants and general practitioners (GPs). The study procedures including assessments and home blood pressure monitoring were acceptable to the participants and their carers. The economic evaluation was not possible. A withdrawal trial of antihypertensive medication in normotensive people with dementia may not be feasible in the UK because of low recruitment rates.

  3. Internet-based cognitive behavioral therapy for adolescents with anxiety disorders: A feasibility study

    DEFF Research Database (Denmark)

    Stjerneklar, Silke; Hougaard, Esben; Nielsen, Amalie D.

    2018-01-01

    Background: Cognitive behavioral therapy (CBT) is a well-documented effective method for the treatment of anxiety disorders in children and adolescents. While internet based CBT (ICBT) programs for adults have been widely investigated, research on ICBT programs for anxiety disorders in youth...... of their primary anxiety disorder). Conclusion: Results from this study indicate that a translated and revised version of the Chilled Out program could be a feasible psychological intervention for Danish adolescents with anxiety disorders....

  4. Effects of vibroacoustic stimulation in music therapy for palliative care patients: a feasibility study.

    Science.gov (United States)

    Warth, Marco; Kessler, Jens; Kotz, Svenja; Hillecke, Thomas K; Bardenheuer, Hubert J

    2015-12-15

    The present study aimed at examining whether methodological strategies from a previously implemented study design could be transferred to the evaluation of the psychological and physiological effects of a music therapy intervention working with vibroacoustic stimulation in palliative care. Nine participants suffering from advanced cancer took part in single-sessions of music therapy, lasting for 30 min. The live music therapy intervention utilized singing chair sounds and vocal improvisation. Visual analogue scales (VAS) were used to assess self-ratings of pain, relaxation, and well-being before and after each session. During the intervention, we continuously recorded heart rate variability (HRV) as a measure of autonomic functioning. Data collection was complemented by a semi-structured interview to explore subjective experiences in more detail. Feasibility was defined as the ability to complete 80 % of the sessions in accordance with the study protocol. In 5 out of 9 sessions (55 %) it was possible to deliver the intervention and obtain all data as intended. VAS assessment was feasible, although graphical and statistical examination revealed only marginal mean changes between pre and post. HRV recordings were subject to artifacts. While HRV parameters differed between individuals, mean changes over time remained relatively constant. Interview data confirmed that the individual perception was very heterogeneous, ranging from "calming" to "overwhelming". The criterion of feasibility was not met in this study. Physiological data showed high attrition rates, most likely due to movement artifacts and reduced peripheral blood flow in some participants' extremities. Examination of individual-level trajectories revealed that vibroacoustic stimulation may have an impact on the autonomic response. However, the direction and mechanisms of effects needs to be further explored in future studies. German Clinical Trials Register - DRKS00006137 (July 4(th), 2014).

  5. Occupational Therapy and Sensory Integration for Children with Autism: A Feasibility, Safety, Acceptability and Fidelity Study

    Science.gov (United States)

    Schaaf, Roseann C.; Benevides, Teal W.; Kelly, Donna; Mailloux-Maggio, Zoe

    2012-01-01

    Objective: To examine the feasibility, safety, and acceptability of a manualized protocol of occupational therapy using sensory integration principles for children with autism. Methods: Ten children diagnosed with autism spectrum disorder ages 4-8 years received intensive occupational therapy intervention using sensory integration principles…

  6. "Merging Yoga and Occupational Therapy (MY-OT): A feasibility and pilot study".

    Science.gov (United States)

    Schmid, Arlene A; Puymbroeck, Marieke Van; Portz, Jennifer D; Atler, Karen E; Fruhauf, Christine A

    2016-10-01

    To examine the feasibility and benefits of the Merging Yoga and Occupational Therapy (MY-OT) intervention. This is the primary analysis of a non-controlled pretest-posttest pilot study to understand the feasibility and impact of MY-OT on balance, balance self-efficacy, and fall risk factor management in people with chronic stroke. University research laboratory. People with chronic stroke were included in the study if they: had sustained a fall or had fear of falling, were able to stand, and hand impaired balance and were at risk for falls (≤46 on the Berg Balance Scale (BBS)). Individuals completed an 8 week intervention that included 16 sessions of both yoga and group occupational therapy (OT). Yoga included physical postures, breathing exercises, and meditation. OT focused on post-stroke fall risk factor management. The BBS was used to assess balance, the Activities-specific Balance Confidence Scale (ABC) was used to measure balance self-efficacy. Five fall risk factor management scales were used. Overall, the intervention was considered feasible, as individuals were able to safely complete the intervention with little attrition and high attendance. Balance improved by 30% (p=0.002). Balance self-efficacy improved by 15% (p=0.034). Each of the five fall risk factor management scales improved, but only two significantly improved (Fall Prevention and Management Questionnaire, 29%, p=0.004 and Fall Prevention Strategy Survey, 42%, p=0.032). The results demonstrate that MY-OT is a potential intervention to improve multiple fall related outcomes for people with stroke. Therapists may consider these interventions for people with stroke, but additional research is warranted. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Feasibility Study Combining Art Therapy or Cognitive Remediation Therapy with Family-based Treatment for Adolescent Anorexia Nervosa.

    Science.gov (United States)

    Lock, James; Fitzpatrick, Kathleen Kara; Agras, William S; Weinbach, Noam; Jo, Booil

    2018-01-01

    Adolescents with anorexia nervosa who have obsessive-compulsive (OC) features respond poorly to family-based treatment (FBT). This study evaluated the feasibility of combining FBT with either cognitive remediation therapy (CRT) or art therapy (AT) to improve treatment response in this at-risk group. Thirty adolescents with anorexia nervosa and OC features were randomized to 15 sessions of FBT + CRT or AT. Recruitment rate was 1 per month, and treatment attrition was 16.6% with no differences between groups. Suitability, expectancy and therapeutic relationships were acceptable for both combinations. Correlations between changes in OC traits and changes in cognitive inefficiencies were found for both combinations. Moderate changes in cognitive inefficiencies were found in both groups but were larger in the FBT + AT combination. This study suggests that an RCT for poor responders to FBT because of OC traits combining FBT with either CRT or AT is feasible to conduct. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

  8. A Cognitive-Behavioral Therapy Group Intervention for Hypersexual Disorder: A Feasibility Study.

    Science.gov (United States)

    Hallberg, Jonas; Kaldo, Viktor; Arver, Stefan; Dhejne, Cecilia; Öberg, Katarina Görts

    2017-07-01

    The proposed criteria of the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition for hypersexual disorder (HD) included symptoms reported by patients seeking help for excessive and out-of-control non-paraphilic sexual behavior, including sexual behaviors in response to dysphoric mood states, impulsivity, and risk taking. Although no prior studies of cognitive-behavioral therapy (CBT) for the treatment of HD have been performed, CBT has been found effective for dysphoric mood states and impulsivity. To investigate the feasibility of a CBT manual developed for HD explored through symptom decrease, treatment attendance, and clients' treatment satisfaction. Ten men with a diagnosis of HD took part in the CBT group program. Measurements were taken before, during, and at the end of treatment and 3 and 6 months after treatment. The primary outcome was the Hypersexual Disorder: Current Assessment Scale (HD:CAS) score that measured the severity of problematic hypersexual symptoms and secondary outcomes were the Hypersexual Disorder Screening Inventory (HDSI) score, the proportion of attended sessions, and the Client Satisfaction Questionnaire (CSQ-8) score. Main results were significant decreases of HD symptoms from before to after treatment on HD:CAS and HDSI scores and a decrease in the number of problematic sexual behaviors during the course of therapy. A high attendance rate of 93% and a high treatment satisfaction score on CSQ-8 also were found. The CBT program seemed to ameliorate the symptoms of HD and therefore might be a feasible treatment option. This study provides data from a CBT program for the treatment of the specific proposed criteria of HD. Because of the small sample and lack of a control group, the results can be considered only preliminary. Although participants reported decreased HD symptoms after attending the CBT program, future studies should evaluate the treatment program with a larger sample and a randomized controlled procedure

  9. SU-E-T-429: Feasibility Study On Three-Dimensional GRID Therapy in Conventional Linacs

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Y; Meyer, J; Timmerman, R; Hrycushko, B; Chen, B; Saha, D; Jiang, S [UT Southwestern Medical Center, Dallas, TX (United States)

    2015-06-15

    Purpose: Two-dimensional GRID therapy, traditionally planned and delivered using a dedicated GRID block or MLC modulation, has shown clinical efficacy in treating bulky tumors. However, the large dose to normal tissues outside target can be limiting. We hypothesize that modulation in the third dimension will improve dose sparing of normal tissues, maximize the bystander effect within the target, and ultimately improve the therapy effectiveness. This study aims to investigate the feasibility of a three-dimensional GRID technique using conventional LINACs to achieve a 3D lattice of high dose volumes within a target. Methods: Datasets of patient’s having large tumor sizes were used to investigate the planning and delivering of 3D GRID using a Varian TrueBeam linac. Original patient contours of PTV are exported from a TPS to DICOManTX where 3D GRID targets are generated in programmable configurations. A structure of avoidance (SOA), i.e., PTV minus GRID targets, is also generated to facilitate inverse planning to achieve the desired pattern. The artificial structures were sent back to the TPS where an IMRT or VMAT plan is designed to deliver a desired high dose to GRID targets while minimizing the dose to the SOA as much as possible. Results: The programmable GRID target generator enables us to modify the target geometry to maximize the peak-to-valley ratio. Preliminary results show that plans based on spherical GRID targets achieve a higher peak-to-valley dose ratio compared with cylindrical targets. High dose spillage outside the target was eliminated. IMRT planning requires the number of beams to be larger than 16, while for VMAT the number of arcs should be at least 4 in order to achieve dosimetric goals. Conclusion: Planning and delivering 3D GRID therapy using conventional LINACs was shown to be feasible. More research and development are required before this new modality can be implemented clinically.

  10. A feasibility study of immediate versus deferred antiretroviral therapy in children with HIV infection

    Directory of Open Access Journals (Sweden)

    Ubolyam Sasiwimol

    2008-10-01

    Full Text Available Abstract Objective To evaluate the feasibility of a large immediate versus deferred antiretroviral therapy (ART study in children. Methods We conducted an open-label pilot randomized clinical trial study in 43 Thai children with CD4 15 to 24% of starting generic AZT/3TC/NVP immediately (Arm 1 or deferring until CD4 Results Recruitment took 15 months. Twenty-six of 69 (37.7% were not eligible due mainly to low CD4%. Twenty four and 19 were randomized to arms 1 and 2 respectively. All accepted the randomized arm; however, 3 in arm 1 stopped ART and 1 in arm 2 refused to start ART. Ten/19 (53% in arm 2 started ART. At baseline, median age was 4.8 yrs, CDC A:B were 36:7, median CD4 was 19% and viral load was 4.8 log. All in arm 1 and 17/19 in arm 2 completed the study (median of 134 weeks. No one had AIDS or death. Four in immediate arm had tuberculosis. Once started on ART, deferred arm children achieved similar CD4 and viral load response as the immediate arm. Adverse events were similar between arms. The deferred arm had a 26% ART saving. Conclusion Almost 40% of children were not eligible due mainly to low CD4% but adherence to randomized treatment and retention in trial were excellent. A larger study to evaluate when to start ART is feasible.

  11. A safety and feasibility study of cell therapy in dilated cardiomyopathy

    Directory of Open Access Journals (Sweden)

    H.F. Martino

    2010-10-01

    Full Text Available The aim of this study was to determine if bone marrow mononuclear cell (BMMC transplantation is safe for moderate to severe idiopathic dilated cardiomyopathy (IDC. Clinical trials have shown that this procedure is safe and effective for ischemic patients, but little information is available regarding non-ischemic patients. Twenty-four patients with IDC, optimized therapy, age 46 ± 11.6 years, 17 males, NYHA classes II-IV, and left ventricular ejection fraction <35% were enrolled in the study. Clinical evaluation at baseline and 6 months after stem cell therapy to assess heart function included echocardiogram, magnetic resonance imaging, cardiopulmonary test, Minnesota Quality of Life Questionnaire, and NYHA classification. After cell transplantation 1 patient showed a transient increase in enzyme levels and 2 patients presented arrhythmias that were reversed within 72 h. Four patients died during follow-up, between 6 and 12 weeks after therapy. Clinical evaluation showed improvement in most patients as reflected by statistically significant decreases in Minnesota Quality of Life Questionnaire (63 ± 17.9 baseline vs 28.8 ± 16.75 at 6 months and in class III-IV NYHA patients (18/24 baseline vs 2/20 at 6 months. Cardiopulmonary exercise tests demonstrated increased peak oxygen consumption (12.2 ± 2.4 at baseline vs 15.8 ± 7.1 mL·kg-1·min-1 at 6 months and walked distance (377.2 ± 85.4 vs 444.1 ± 77.9 m at 6 months in the 6-min walk test, which was not accompanied by increased left ventricular ejection fraction. Our findings indicate that BMMC therapy in IDC patients with severe ventricular dysfunction is feasible and that larger, randomized and placebo-controlled trials are warranted.

  12. A Pilot Feasibility Study of Whole-systems Ayurvedic Medicine and Yoga Therapy for Weight Loss.

    Science.gov (United States)

    Rioux, Jennifer; Thomson, Cynthia; Howerter, Amy

    2014-01-01

    To develop and test the feasibility of a whole-systems lifestyle intervention for obesity treatment based on the practices of Ayurvedic medicine/ Yoga therapy. A pre-post weight loss intervention pilot study using conventional and Ayurvedic diagnosis inclusion criteria, tailored treatment within a standardized treatment algorithm, and standardized data collection instruments for collecting Ayurvedic outcomes. A convenience sample of overweight/obese adult community members from Tucson, Arizona interested in a "holistic weight loss program" and meeting predetermined inclusion/exclusion criteria. A comprehensive diet, activity, and lifestyle modification program based on principles of Ayurvedic medicine/yoga therapy with significant self-monitoring of lifestyle behaviors. The 3-month program was designed to change eating and activity patterns and to improve self-efficacy, quality of life, well-being, vitality, and self-awareness around food choices, stress management, and barriers to weight loss. Changes in body weight, body mass index; body fat percentage, fat/lean mass, waist/hip circumference and ratio, and blood pressure. Diet and exercise self-efficacy scales; perceived stress scale; visual analog scales (VAS) of energy, appetite, stress, quality of life, well-being, and program satisfaction at all time points. Twenty-two adults attended an in-person Ayurvedic screening; 17 initiated the intervention, and 12 completed the 3-month intervention. Twelve completed follow-up at 6 months and 11 completed follow-up at 9 months. Mean weight loss at 3 months was 3.54 kg (SD 4.76); 6 months: 4.63 kg, (SD 6.23) and 9 months: 5.9 kg (SD 8.52). Self-report of program satisfaction was more than 90% at all time points. An Ayurveda-/yoga-based lifestyle modification program is an acceptable and feasible approach to weight management. Data collection, including self-monitoring and conventional and Ayurvedic outcomes, did not unduly burden participants, with attrition similar to

  13. The impact of occupational therapy in Parkinson's disease: a randomized controlled feasibility study

    NARCIS (Netherlands)

    Sturkenboom, I.H.W.M.; Graff, M.J.L.; Borm, G.F.; Veenhuizen, Y.; Bloem, B.R.; Munneke, M.; Nijhuis-Van der Sanden, M.W.G.

    2013-01-01

    AIM: To evaluate the feasibility of a randomized controlled trial including process and potential impact of occupational therapy in Parkinson's disease. DESIGN: Process and outcome were quantitatively and qualitatively evaluated in an exploratory multicentre, two-armed randomized controlled trial at

  14. Feasibility Study of a Mobile Health Intervention for Older Adults on Oral Anticoagulation Therapy

    Directory of Open Access Journals (Sweden)

    Jung-Ah Lee PhD, RN

    2016-10-01

    Full Text Available Background: Oral anticoagulation treatment (OAT such as warfarin therapy is recommended for older adults with atrial fibrillation, heart failure, or who are at risk for venous thromboembolism. Despite its proven benefits, older adults report both dissatisfaction with OAT and reduced quality of life that can potentially lead to low adherence to OAT and decreased treatment efficacy. Objective: To test the feasibility of Mobile Applications for Seniors to enhance Safe anticoagulation therapy (MASS, a mobile-based health technology intervention designed to promote independence and self-care. Method s: This pilot study used a single-arm experimental pre–post design to test the feasibility of a 3-month intervention using MASS in 18 older adults (male: n = 14; White: n = 9; Hispanic: n = 7; Other: n = 2; M age = 67. MASS was available in English or Spanish. Participants completed surveys about their OAT knowledge, attitudes, quality of life with OAT, and adherence at baseline and at a 3-month follow-up. Satisfaction with the MASS intervention was also assessed at follow-up. Results: Anticoagulation knowledge significantly improved from baseline to follow-up ( M base = 12.5 ± 5.51, M follow-up = 14.78 ± 3.93, p = .007. Other outcomes were not different, pre- and post-tests. Participants reported they were generally satisfied with MASS, its ease of use and its usefulness. Conclusion: The results showed use of MASS improved older adults’ knowledge of OAT. Using mHealth apps may enhance self-care among older adults with chronic conditions who are also taking oral anticoagulants.

  15. Acceptance and commitment therapy universal prevention program for adolescents: a feasibility study.

    Science.gov (United States)

    Burckhardt, Rowan; Manicavasagar, Vijaya; Batterham, Philip J; Hadzi-Pavlovic, Dusan; Shand, Fiona

    2017-01-01

    There is a need to prevent anxiety and depression in young people and mindfulness contains important emotion regulation strategies. Acceptance and commitment therapy (ACT), a mindfulness-based therapy, has yet to be evaluated as a prevention program, but has demonstrated an ability to reduce symptoms of anxiety and depression in adult and adolescent populations. This study examines the feasibility of using an ACT-based prevention program in a sample of year 10 (aged 14-16 years) high school students from Sydney, Australia. Participants were allocated to either their usual classes or to the ACT-based intervention. Participants were followed for a period of 5 months post-intervention and completed the Flourishing Scale, Depression Anxiety Stress Scale, and a program evaluation questionnaire. Analyses were completed using intention-to-treat mixed models for repeated measures. The results indicated that the intervention was acceptable to students and feasible to administer in a school setting. There were no statistically significant differences between the conditions, likely due to the small sample size (N = 48). However, between-group effect sizes demonstrated small to large differences for baseline to post-intervention mean scores and medium to large differences for baseline to follow-up mean scores, all favouring the ACT-based condition. The results suggest that an ACT-based school program has potential as a universal prevention program and merits further investigation in a larger trial. Trial registration Australian New Zealand Clinical Trials Registry. Trial ID: ACTRN12616001383459. Registered 06/10/2016. Retrospectively registered.

  16. Fixing the Mirrors: A Feasibility Study of the Effects of Dance Movement Therapy on Young Adults with Autism Spectrum Disorder

    Science.gov (United States)

    Koch, Sabine C.; Mehl, Laura; Sobanski, Esther; Sieber, Maik; Fuchs, Thomas

    2015-01-01

    From the 1970s on, case studies reported the effectiveness of therapeutic mirroring in movement with children with autism spectrum disorder. In this feasibility study, we tested a dance movement therapy intervention based on mirroring in movement in a population of 31 young adults with autism spectrum disorder (mainly high-functioning and…

  17. Virtual Reality Exposure Therapy for the Treatment of Dental Phobia: A Controlled Feasibility Study.

    Science.gov (United States)

    Gujjar, Kumar Raghav; van Wijk, Arjen; Sharma, Ratika; de Jongh, Ad

    2017-09-14

    Virtual reality exposure therapy (VRET) has been used to treat a variety of fears and phobias. To determine the feasibility (i.e. safety and efficacy) of using VRET to treat dental phobia. Safety was evaluated by determining any adverse events or symptom exacerbation. Efficacy of VRET was evaluated by comparing the reduction in dental anxiety scores (measured 16 times within a 14-week study period, and at 6-month follow-up), and its behavioural effects with that of an informational pamphlet (IP) on ten randomized patients with dental phobia using a controlled multiple baseline design. Participants' heart rate response during VRET, and their experience post-VRET, were indexed. No personal adverse events or symptom exacerbation occurred. Visual analysis and post-hoc intention-to-treat analysis showed a significantly greater decrease in dental anxiety scores [higher PND (percentage of non-overlap data) scores of 100% and lower POD (percentage of overlap data) of 0%, Modified Dental Anxiety Scale, F (1,8) = 8.61, p = 0.019, and Dental Fear Scale, F (1,8) = 10.53, p = 0.012], and behavioural avoidance in the VRET compared with the IP group [d = 4.2 and -1.4, respectively). There was no increase in average heart rate during VRET. Of the nine treatment completers, six (four from the VRET group and two from the IP group) no longer had dental phobia at 6-month follow-up. Four of the five VRET participants, but none of the IP participants, scheduled a dental treatment appointment following the intervention. VRET is a feasible alternative for patients with dental phobia.

  18. Individual music therapy for managing neuropsychiatric symptoms for people with dementia and their carers: a cluster randomised controlled feasibility study.

    Science.gov (United States)

    Hsu, Ming Hung; Flowerdew, Rosamund; Parker, Michael; Fachner, Jörg; Odell-Miller, Helen

    2015-07-18

    Previous research highlights the importance of staff involvement in psychosocial interventions targeting neuropsychiatric symptoms of dementia. Music therapy has shown potential effects, but it is not clear how this intervention can be programmed to involve care staff within the delivery of patients' care. This study reports initial feasibility and outcomes from a five month music therapy programme including weekly individual active music therapy for people with dementia and weekly post-therapy video presentations for their carers in care homes. 17 care home residents and 10 care staff were randomised to the music therapy intervention group or standard care control group. The cluster randomised, controlled trial included baseline, 3-month, 5-month and post-intervention 7-month measures of residents' symptoms and well-being. Carer-resident interactions were also assessed. Feasibility was based on carers' feedback through semi-structured interviews, programme evaluations and track records of the study. The music therapy programme appeared to be a practicable and acceptable intervention for care home residents and staff in managing dementia symptoms. Recruitment and retention data indicated feasibility but also challenges. Preliminary outcomes indicated differences in symptoms (13.42, 95 % CI: [4.78 to 22.07; p = 0.006]) and in levels of wellbeing (-0.74, 95 % CI: [-1.15 to -0.33; p = 0.003]) between the two groups, indicating that residents receiving music therapy improved. Staff in the intervention group reported enhanced caregiving techniques as a result of the programme. The data supports the value of developing a music therapy programme involving weekly active individual music therapy sessions and music therapist-carer communication. The intervention is feasible with modifications in a more rigorous evaluation of a larger sample size. Clinicaltrials.gov, number NCT01744600.

  19. Integrative Acupuncture and Spinal Manipulative Therapy Versus Either Alone for Low Back Pain: A Randomized Controlled Trial Feasibility Study.

    Science.gov (United States)

    Kizhakkeveettil, Anupama; Rose, Kevin A; Kadar, Gena E; Hurwitz, Eric L

    The objective of this study was to assess the feasibility of conducting a large-scale randomized controlled trial (RCT) examining whether an integrative care model combining spinal manipulative therapy (SMT) and acupuncture can lead to better outcomes for low back pain (LBP) than either therapy alone. This study was conducted at a complementary and alternative medicine university health center. Participants with acute or chronic LBP were randomized to (1) acupuncture, (2) SMT, or (3) integrative acupuncture and SMT groups. Treatments were provided over 60 days by licensed doctors of chiropractic and acupuncturists. Acupuncture treatments consisted of needling of acupoints combined with electrotherapy, moxibustion, cupping, and Tui Na. SMT used specific contact points on vertebral processes, along with soft tissue therapy and physiotherapy. Primary outcome measures were the Roland-Morris LBP Disability Questionnaire and 0 to 10 Numeric Rating Scale for LBP. Participants in all 3 groups experienced clinically meaningful improvements in the primary outcome measures; however, no between-group differences in outcomes were apparent. This study indicated that it is feasible to conduct an RCT to compare the effectiveness of integrative acupuncture and SMT for LBP to either therapy alone. Future studies should include a larger sample to increase the power for detecting clinically meaningful differences between groups. Copyright © 2017. Published by Elsevier Inc.

  20. Computerised cognitive behaviour therapy for depression in adolescents: study protocol for a feasibility randomised controlled trial.

    Science.gov (United States)

    Wright, Barry; Tindall, Lucy; Littlewood, Elizabeth; Adamson, Joy; Allgar, Victoria; Bennett, Sophie; Gilbody, Simon; Verduyn, Chrissie; Alderson-Day, Ben; Dyson, Lisa; Trépel, Dominic; Ali, Shehzad

    2014-10-31

    The 1 year prevalence of depression in adolescents is about 2%. Treatment with antidepressant medication is not recommended for initial treatment in young people due to concerns over high side effects, poor efficacy and addictive potential. Evidence suggests that cognitive behaviour therapy (CBT) is an effective treatment for depression and is currently one of the main treatment options recommended in adolescents. Given the affinity young people have with information technology they may be treated effectively, more widely and earlier in their illness evolution using computer-administered CBT (CCBT). Currently little is known about the clinical and resource implications of implementing CCBT within the National Health Service for adolescents with low mood/depression. We aim to establish the feasibility of running a fully powered randomised controlled trial (RCT). Adolescents aged 12-18 with low mood/depression, (scoring ≥20 on the Mood and Feelings Questionnaire (MFQ)), will be approached to participate. Consenting participants will be randomised to either a CCBT programme (Stressbusters) or accessing selected websites providing information about low mood/depression. The primary outcome measure will be the Beck Depression Inventory (BDI). Participants will also complete generic health measures (EQ5D-Y, HUI2) and resource use questionnaires to examine the feasibility of cost-effectiveness analysis. Questionnaires will be completed at baseline, 4 and 12-month follow-ups. Progress and risk will be monitored via the MFQ administered at each treatment session. The acceptability of a CCBT programme to adolescents; and the willingness of clinicians to recruit participants and of participants to be randomised, recruitment rates, attrition rates and questionnaire completion rates will be collected for feasibility analysis. We will estimate 'numbers needed' to plan a fully powered RCT of clinical and cost-effectiveness. The current trial protocol received a favourable

  1. A Pilot Study to Assess the Feasibility of Group Exercise and Animal-Assisted Therapy in Older Adults.

    Science.gov (United States)

    Grubbs, Brandon; Artese, Ashley; Schmitt, Karla; Cormier, Eileen; Panton, Lynn

    2016-04-01

    This pilot study assessed the feasibility of incorporating animal-assisted therapy teams (ATT) into a 6-week group exercise program for older adults (77 ± 6 years). Fifteen participants were randomly assigned to an exercise with ATT (E+ATT; n = 8) or exercise only (E; n = 7) group. Groups exercised 3x/week for 45 min. Feasibility was assessed by three objectives: (1) ATT will not need extensive preparation beyond their original therapy training; (2) the study will require minimal cost; and (3) ATT must not impair the effectiveness of the exercise program. By the study conclusion, all objectives were met. Time and cost were minimal for ATT, and adherence was 93% and 90% for E+ATT and E, respectively. There were significant improvements in both groups (p ≤ .05) for arm curls, get-up and go, and 6-min walk. The results of this pilot study suggest that it is feasible to incorporate ATT into group exercise programming for older adults.

  2. A single-group pilot feasibility study of cognitive behavioural therapy in people with multiple sclerosis with depressive symptoms.

    Science.gov (United States)

    Chruzander, Charlotte; Gottberg, Kristina; Ytterberg, Charlotte; Backenroth, Gunnel; Fredrikson, Sten; Widén Holmqvist, Lotta; Johansson, Sverker

    2016-12-01

    The aims were to evaluate (a) the feasibility of face-to-face cognitive behavioural therapy (CBT) in people with MS (PwMS) with depressive symptoms; (b) the feasibility of methods and measurements used; and (c) the outcome of the intervention before the conducting of an equivalence study of comparative methods of face-to-face CBT. A single-group pilot feasibility study. PwMS (n = 15) with sub-threshold to moderate depressive symptoms, recruited at the Karolinska University Hospital, Stockholm, Sweden. The intervention consisted of 15-20 sessions of face-to-face CBT. Feasibility outcomes included recruitment rate, recruitment procedure and adverse events. Primary clinical outcome was the Beck Depression Inventory-II (BDI-II). Follow-ups were conducted after 3 weeks and 3 months. An estimated sample size calculation was conducted. The face-to-face CBT intervention, methods and measurements used were feasible. The outcome on BDI-II indicated that face-to-face CBT is an effective method for alleviating sub-threshold to moderate depressive symptoms in PwMS. Face-to-face CBT is feasible for use in PwMS aiming at decrease depressive symptoms. For an equivalence study, a screening process for depressive symptoms and two comparative intervention arms including traditional face-to-face CBT and low-intensity face-to-face CBT is recommended. Primary outcomes should include the BDI-II and also assessment of anxiety symptoms. Implications for Rehabilitation Depression is common among people with MS (PwMS), however, depressed PwMS do not always receive adequate treatment for depression which may lead to increased disability and worse health-related quality of life (HRQL). Cognitive behavioural therapy (CBT) is a psychological treatment method that might be beneficial for PwMS with depressive symptoms, but the evidence is still weak and further research is needed. The results from our pilot feasibility study demonstrate that for an effectiveness study of face-to-face CBT for

  3. Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-Month Feasibility Study

    Science.gov (United States)

    Eack, Shaun M.; Greenwald, Deborah P.; Hogarty, Susan S.; Bahorik, Amber L.; Litschge, Maralee Y.; Mazefsky, Carla A.; Minshew, Nancy J.

    2013-01-01

    Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to…

  4. Feasibility study of volumetric modulated arc therapy with constant dose rate for endometrial cancer

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Ruijie [Department of Radiation Oncology, Peking University Third Hospital, Beijing (China); Wang, Junjie, E-mail: junjiewang47@yahoo.com [Department of Radiation Oncology, Peking University Third Hospital, Beijing (China); Xu, Feng [Department of Biomedical Engineering, Peking University Third Hospital, Beijing (China); Li, Hua [Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing (China); Zhang, Xile [Department of Radiation Oncology, Peking University Third Hospital, Beijing (China)

    2013-10-01

    To investigate the feasibility, efficiency, and delivery accuracy of volumetric modulated arc therapy with constant dose rate (VMAT-CDR) for whole-pelvic radiotherapy (WPRT) of endometrial cancer. The nine-field intensity-modulated radiotherapy (IMRT), VMAT with variable dose-rate (VMAT-VDR), and VMAT-CDR plans were created for 9 patients with endometrial cancer undergoing WPRT. The dose distribution of planning target volume (PTV), organs at risk (OARs), and normal tissue (NT) were compared. The monitor units (MUs) and treatment delivery time were also evaluated. For each VMAT-CDR plan, a dry run was performed to assess the dosimetric accuracy with MatriXX from IBA. Compared with IMRT, the VMAT-CDR plans delivered a slightly greater V{sub 20} of the bowel, bladder, pelvis bone, and NT, but significantly decreased the dose to the high-dose region of the rectum and pelvis bone. The MUs decreased from 1105 with IMRT to 628 with VMAT-CDR. The delivery time also decreased from 9.5 to 3.2 minutes. The average gamma pass rate was 95.6% at the 3%/3 mm criteria with MatriXX pretreatment verification for 9 patients. VMAT-CDR can achieve comparable plan quality with significant shorter delivery time and smaller number of MUs compared with IMRT for patients with endometrial cancer undergoing WPRT. It can be accurately delivered and be an alternative to IMRT on the linear accelerator without VDR capability.

  5. Feasibility study of a game integrating assessment and therapy of tinnitus.

    Science.gov (United States)

    Wise, K; Kobayashi, K; Searchfield, G D

    2015-07-15

    Tinnitus, head and ear noise, is due to maladaptive plastic changes in auditory and associated neural networks. Tinnitus has been traditionally managed through the use of sound to passively mask or facilitate habituation to tinnitus, a process that may take 6-12 months. A game-based perceptual training method, requiring localisation and selective attention to sounds, was developed and customised to the individual's tinnitus perception. Eight participants tested the games usability at home. Each participant successfully completed 30 min of training, for 20 days, along with daily psychoacoustic assessment of tinnitus pitch and loudness. The training period and intensity of training appears sufficient to reduce tinnitus handicap. The training approach used may be a viable alternative to frequency discrimination based training for treating tinnitus (Hoare et al., 2014) and a useful tool in exploring learning mechanisms in the auditory system. Integration of tinnitus assessment with therapy in a game is feasible, and the method(s) warrant further investigation. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Feasibility of virtual therapy in rehabilitation of Parkinson's disease patients: pilot study

    Directory of Open Access Journals (Sweden)

    Ana Paula Cunha Loureiro

    Full Text Available INTRODUCTION: Among Parkinson's disease (PD motor disabilities, postural and balance alterations are important parameters to physical therapists who need to choose specific, targeted therapies for their patients. Among many therapy options, virtual therapy is studied as to whether it can be a viable rehabilitation method. OBJECTIVE: To verify the applicability of virtual rehabilitation in PD patients for the improvement of their balance and quality of life. MATERIAL AND METHODS: Six volunteers, diagnosed to be in Stages II and III of PD (Hoehn and Yahr Scale, were recruited for this study. Patients (65 ± 13 years old participated in activities involving Wii Fit, for a total of twelve interventions, twice per week. Clinical and qualitative methods were used for the data collection for the initial and final evaluations: Borg's Scale, Berg Functional Balance Scale, Time Up and Go, anterior and lateral functional reach and Nottingham's Scale were performed during the study. Penguin Slide, Ski Slalom, Soccer Heading and Table Tilt were the Wii games selected as a form of virtual therapy. RESULTS: The collected data were analyzed using the Wilcoxon test. Motor skill, functional capacities and quality of life were analyzed as variables of the patients' balance. Statistically significant differences were found in the following tests: Borg's Scale (p = 0.0464, Berg Functional Balance Scale (p = 0.0277, lateral functional reach to the right (p = 0.0431* and lateral functional reach to the left (p = 0.0277. CONCLUSION: It is believed that exercises with virtual reality therapy can be a useful tool to improve the balance in PD patients.

  7. Intradialytic Laughter Yoga therapy for haemodialysis patients: a pre-post intervention feasibility study.

    Science.gov (United States)

    Bennett, Paul N; Parsons, Trisha; Ben-Moshe, Ros; Neal, Merv; Weinberg, Melissa K; Gilbert, Karen; Ockerby, Cherene; Rawson, Helen; Herbu, Corinne; Hutchinson, Alison M

    2015-06-09

    Laughter Yoga consists of physical exercise, relaxation techniques and simulated vigorous laughter. It has been associated with physical and psychological benefits for people in diverse clinical and non-clinical settings, but has not yet been tested in a haemodialysis setting. The study had three aims: 1) to examine the feasibility of conducting Laughter Yoga for patients with end stage kidney disease in a dialysis setting; 2) to explore the psychological and physiological impact of Laughter Yoga for these patients; and 3) to estimate the sample size required for future research. Pre/post intervention feasibility study. Eighteen participants were recruited into the study and Laughter Yoga therapists provided a four week intradialytic program (30-min intervention three times per week). Primary outcomes were psychological items measured at the first and last Laughter Yoga session, including: quality of life; subjective wellbeing; mood; optimism; control; self-esteem; depression, anxiety and stress. Secondary outcomes were: blood pressure, intradialytic hypotensive episodes and lung function (forced expiratory volume). Dialysis nurses exposed to the intervention completed a Laughter Yoga attitudes and perceptions survey (n = 11). Data were analysed using IBM SPSS Statistics v22, including descriptive and inferential statistics, and sample size estimates were calculated using G*Power. One participant withdrew from the study for medical reasons that were unrelated to the study during the first week (94 % retention rate). There were non-significant increases in happiness, mood, and optimism and a decrease in stress. Episodes of intradialytic hypotension decreased from 19 pre and 19 during Laughter Yoga to 4 post Laughter Yoga. There was no change in lung function or blood pressure. All nurses agreed or strongly agreed that Laughter Yoga had a positive impact on patients' mood, it was a feasible intervention and they would recommend Laughter Yoga to their patients. Sample

  8. Feasibility Study of EUS-NOTES as a Novel Approach for Pancreatic Cancer Staging and Therapy

    DEFF Research Database (Denmark)

    Săftoiu, Adrian; Bhutani, Manoop S; Vilmann, Peter

    2012-01-01

    Background/Aims: EUS guided Natural Orifice Transluminal Endoscopic Surgery (NOTES) could be a potentially viable approach for pancreatic surgery. EUS-guided access through the stomach wall may prove to be a safe and effective method for accessing the pancreas. The aim of the study was to assess...... the EUS-guided diagnostic and therapeutic procedures during NOTES for both anterior and posterior approach of the pancreas. Methodology: The feasibility of peritoneoscopy through an anterior EUS-guided transgastric approach, as well as direct access to the pancreas through a posterior EUS......-guided transgastric approach was tested for ease of access to the tail of the pancreas. Gastric wound closure was finally performed in several animals using various commercial and prototype endoscopic accessories. Results: The results showed the ability of EUS-NOTES technology to facilitate a transgastric approach...

  9. Acceptance and commitment therapy universal prevention program for adolescents: a feasibility study

    National Research Council Canada - National Science Library

    Rowan Burckhardt; Vijaya Manicavasagar; Philip J Batterham; Dusan Hadzi-Pavlovic; Fiona Shand

    2017-01-01

    .... Acceptance and commitment therapy (ACT), a mindfulness-based therapy, has yet to be evaluated as a prevention program, but has demonstrated an ability to reduce symptoms of anxiety and depression in adult and adolescent populations...

  10. PROTON THERAPY IN COMBINATION WITH PET AS MONITOR - A FEASIBILITY STUDY

    NARCIS (Netherlands)

    PAANS, AMJ; SCHIPPERS, JM

    To evaluate the possibility of combining proton therapy with Positron Emission Tomography (PET) as a therapy monitor and as a tool for in situ dosimetry during therapy, proton activiation experiments have been performed using a 55 MeV proton beam on two different materials. The 3-D measurements of

  11. Feasibility studies of a passive scatter proton therapy nozzle without a range modulator wheel.

    Science.gov (United States)

    Harvey, Mark C; Polf, Jerimy C; Smith, Alfred R; Mohan, Radhe

    2008-06-01

    The purpose of this work was to determine the feasibility of producing a spread out Bragg peak (SOBP) without a range modulation wheel (RMW) using the passive scattering beam delivery technique. For this study, a comprehensive Monte Carlo model of a passive scattering treatment nozzle was used. The RMW was removed from the model leaving only the initial fixed scatterer (RMW-free configuration). Range modulation was achieved by directly changing the energy of the proton beam entering the nozzle. To produce a uniform SOBP, the number of protons injected into the nozzle at each beam energy was "dose weighted." To do so, the effective number of protons was calculated for the individual initial energies using an analytical dose-weighting function, and the resulting weighted Bragg curves were summed together to produce an SOBP of the desired width. We found that SOBPs calculated using the RMW-free nozzle configuration were in very good agreement to those calculated with the standard nozzle configuration containing the RMW for the 250, 180, and 100 MeV maximum beam energies. The depth of the distal 90% dose and the 80%-20% distal dose falloff of SOBPs calculated with the two different nozzle configurations agreed to within a millimeter for the three beam energy options considered in this study. In addition, the 80%-20% lateral penumbra for the cross-field dose profiles calculated with the RMW-free delivery method agreed with results calculated using the standard RMW technique to less than one millimeter. For an equal number of protons injected into the nozzle, an increase of up to 10% in the delivered dose and a significant reduction in both the in-air secondary neutron fluence and dose equivalent (H/D) were observed at the isocenter by removing the RMW from the treatment nozzle and modulating the initial proton beam energy. However, increases in delivery time of up to 70% were also estimated with this method. Our results suggest that it is feasible to deliver a passively

  12. Patterns of Substance Use During Cognitive Enhancement Therapy: An 18-Month Randomized Feasibility Study.

    Science.gov (United States)

    Eack, Shaun M; Hogarty, Susan S; Bangalore, Srihari S; Keshavan, Matcheri S; Cornelius, Jack R

    2016-01-01

    Substance use problems are common among people with schizophrenia, as are significant cognitive impairments. Because of potential shared neurobiological pathways, it is possible that cognitive remediation interventions may be associated with improvements in both substance use and cognition. This study examined the impact of cognitive remediation on alcohol and cannabis use and the cognitive correlates of changes in substance use among outpatients with schizophrenia. Individuals with schizophrenia who were receiving outpatient services at a psychiatric clinic and had moderate or higher addiction severity scores (N = 31) were randomized to 18 months of cognitive enhancement therapy (n = 22) or usual care (n = 9). Cognitive enhancement therapy is a cognitive remediation approach that integrates computer-based training in attention, memory, and problem solving with a group-based social cognition curriculum. Usual care was provided to all participants and consisted of routine psychiatric care. Primary outcomes included days of alcohol and cannabis use, assessed with the Timeline Followback method every six months and modeled using penalized quasi-likelihood growth curves. Participants were on average 38.23 (SD = 13.44) years of age, had been ill for 14.19 (SD = 11.28) years, and were mostly male (n = 22, 71%), and about half were Caucasian (n = 16, 52%). Temporal patterns of substance use days were highly variable and followed nonlinear trajectories. Intent-to-treat analyses indicated that, compared to patients only receiving usual care, those receiving cognitive enhancement therapy were significantly less likely to use alcohol (OR = .22; 95% CI: .05, .90; p = .036), but not cannabis (OR = 1.89; 95% CI: .02, 142.99; p = .774) over time, and they reduced their alcohol use at significantly accelerated rates (OR = 1.02; 95% CI: 1.01, 1.03; p = .003). Changes in cognition were variably associated with substance use outcomes, although improvements in visual learning and

  13. Vocal Music Therapy for Chronic Pain Management in Inner-City African Americans: A Mixed Methods Feasibility Study.

    Science.gov (United States)

    Bradt, Joke; Norris, Marisol; Shim, Minjung; Gracely, Edward J; Gerrity, Patricia

    2016-01-01

    To date, research on music for pain management has focused primarily on listening to prerecorded music for acute pain. Research is needed on the impact of active music therapy interventions on chronic pain management. The aim of this mixed methods research study was to determine feasibility and estimates of effect of vocal music therapy for chronic pain management. Fifty-five inner-city adults, predominantly African Americans, with chronic pain were randomized to an 8-week vocal music therapy treatment group or waitlist control group. Consent and attrition rates, treatment compliance, and instrument appropriateness/burden were tracked. Physical functioning (pain interference and general activities), self-efficacy, emotional functioning, pain intensity, pain coping, and participant perception of change were measured at baseline, 4, 8, and 12 weeks. Focus groups were conducted at the 12-week follow-up. The consent rate was 77%. The attrition rate was 27% at follow-up. We established acceptability of the intervention. Large effect sizes were obtained for self-efficacy at weeks 8 and 12; a moderate effect size was found for pain interference at week 8; no improvements were found for general activities and emotional functioning. Moderate effect sizes were obtained for pain intensity and small effect sizes for coping, albeit not statistically significant. Qualitative findings suggested that the treatment resulted in enhanced self-management, motivation, empowerment, a sense of belonging, and reduced isolation. This study suggests that vocal music therapy may be effective in building essential stepping-stones for effective chronic pain management, namely enhanced self-efficacy, motivation, empowerment, and social engagement. © the American Music Therapy Association 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. Cognitive Behavioral Therapy as an Adjunct Treatment to Light Therapy for Delayed Sleep Phase Disorder in Young Adults: A Randomized Controlled Feasibility Study.

    Science.gov (United States)

    Danielsson, Katarina; Jansson-Fröjmark, Markus; Broman, Jan-Erik; Markström, Agneta

    2016-01-01

    Delayed sleep phase disorder (DSPD) is common among young people, but there is still no evidence-based treatment available. In the present study, the feasibility of cognitive behavioral therapy (CBT) was evaluated as an additive treatment to light therapy (LT) in DSPD. A randomized controlled trial with participants aged 16 to 26 years received LT for two weeks followed by either four weeks of CBT or no treatment (NT). LT advanced sleep-wake rhythm in both groups. Comparing LT+CBT with LT+NT, no significant group differences were observed in the primary endpoints. Although anxiety and depression scores were low at pretreatment, they decreased significantly more in LT+CBT compared to LT+NT. The results are discussed and some suggestions are given for further studies.

  15. The feasibility of brief dog-assisted therapy on university students stress levels: the PAwS study.

    Science.gov (United States)

    Wood, Emily; Ohlsen, Sally; Thompson, Jennifer; Hulin, Joe; Knowles, Louise

    2017-10-06

    Pet therapy is becoming increasingly popular and is used in a variety of ways from encouraging communication in older adults to improving wellbeing in those with serious mental illness. Increasingly Universities have been offering pet therapy to students in an effort to reduce stress. However, little evidence currently exists to support the effectiveness of reducing measurable stress levels after a standalone drop-in unstructured session. The University of Sheffield's Counselling Service works in partnership with Guide Dogs for the Blind to give students access to calm, well-trained animals for informal group stress relief. To assess the feasibility of implementing and evaluating unstructured group interventions with a Guide Dog in training within the university student population. One hundred and thirty-one students who attended pet therapy at the University Counselling Service were recruited on a voluntary basis to take part in the research. Stress, measured on the state trait anxiety inventory, and blood pressure were taken before and after a 15-min intervention. All measures showed a statistically significant reduction immediately after the intervention. Short interactions with a Guide Dog in training appear to reduce stress in University students. A controlled study is required to investigate further.

  16. A new educational film control for use in studies of active mind-body therapies: acceptability and feasibility.

    Science.gov (United States)

    Innes, Kim E; Selfe, Terry Kit; Alexander, Gina K; Taylor, Ann Gill

    2011-05-01

    The study objectives were to ascertain whether a novel educational film class is an acceptable and feasible comparison group for a randomized controlled trial regarding the effects of an active mind-body therapy on cardiovascular disease risk in postmenopausal women. Seventy-five (75) participants attended a baseline assessment visit and were randomly assigned to either a yoga group or an educational film (control) group. Both groups attended two 90-minute classes/week for 8 weeks, followed by a second assessment visit. Those not attending the second assessment were classified as dropouts. Over 60 films covering a range of topics relevant to the study population were evaluated; 15 were selected by consensus of at least 2 researchers and 1 layperson. Each film session followed the same format: an informal greeting period, viewing of the film, and a 15-minute postfilm discussion. To determine acceptability and feasibility of the film class, potential between-group differences in dropout and attendance were examined, and participant feedback given during class and on end-of-study questionnaires were evaluated. The relation between group assignment and dropout was not significant (χ(2) [1, N = 75] = 0.14, p = 0.71). One-way analysis of variance (ANOVA) indicated no significant between-group difference in number of classes attended for the yoga (X = 13.67 ± 3.10) versus film group (13.26 ± 1.97), F(1,63) = 0.39, p = 0.53). Participant feedback regarding the film program was positive. These findings support the feasibility and acceptability of this educational film control. Easy to standardize and tailor to a variety of populations, this film program may offer an attractive alternative to the more traditional educational control.

  17. Boron Neutron Capture Therapy for HER2+ breast cancers: A feasibility study evaluating BNCT for potential role in breast conservation therapies

    Science.gov (United States)

    Jenkins, Peter Anthony

    A novel Boron Neutron Capture Therapy (BNCT) regimen for the treatment of HER2+ breast cancers has been proposed as an alternative to whole breast irradiation for breast conservation therapy patients. The proposed therapy regimen is based on the assumed production of boron delivery agents that would be synthesized from compounds of Trastuzumab (Herceptin ®) and oligomeric phosphate diesters (OPDs). The combination of the anti-HER2 monoclonal antibody and the high boron loading capability of OPDs has led to the assumption that boron could be delivered to the HER2+ cancer cells at Tumor to Healthy Tissue ratios (T:H) of up to 35:1 and boron concentrations above 50 μg/g. This significantly increased boron delivery efficiency has opened new BNCT possibilities. This proof of concept study examined treatment parameters derived as the results in previous efforts in the context of patient-specific geometry and compared calculated dose results to those observed during actual patient therapy. These results were based on dose calculations performed with a set of calculated Kerma coefficients derived from tissues specific to the regions of interest for breast cancer. A comparison was made of the dose to the tumor region, the patient's skin, and the peripheral organs. The results of this study demonstrated that, given the performance of the proposed boron delivery agent, the BNCT treatment regimen is feasible. The feasibility is based on the findings that the equivalent dose could be delivered to the treatment volume with less dose to the skin and peripheral organs. This is anticipated to improve the treatment outcomes by maintaining local control of tumor cells while reducing dose to healthy tissues.

  18. Vocal Music Therapy for Chronic Pain Management in Inner City African Americans: A Mixed Methods Feasibility Study

    Science.gov (United States)

    Bradt, Joke; Norris, Marisol; Shim, Minjung; Gracely, Edward J.; Gerrity, Patricia

    2017-01-01

    Background To date, research on music for pain management has focused primarily on listening to pre-recorded music for acute pain. Research is needed on the impact of active music therapy interventions on chronic pain management. Objective The aim of this mixed methods research study was to determine feasibility and estimates of effect of vocal music therapy for chronic pain management. Methods Fifty-five inner city adults, predominantly African-Americans, with chronic pain were randomized to an 8-week vocal music therapy treatment group or waitlist control group. Consent and attrition rates, treatment compliance, and instrument appropriateness/burden were tracked. Physical functioning (pain interference and general activities), self-efficacy, emotional functioning, pain intensity, pain coping, and participant perception of change were measured at baseline, 4, 8, and 12 weeks. Focus groups were conducted at the 12-week follow-up. Results The consent rate was 77%. The attrition rate was 27% at follow-up. We established acceptability of the intervention. Large effect sizes were obtained for self-efficacy at weeks 8 and 12; a moderate effect size was found for pain interference at week 8; no improvements were found for general activities and emotional functioning. Moderate effect sizes were obtained for pain intensity and small effect sizes for coping, albeit not statistically significant. Qualitative findings suggested that the treatment resulted in enhanced self-management, motivation, empowerment, a sense of belonging, and reduced isolation. Conclusions This study suggests that vocal music therapy may be effective in building essential stepping stones for effective chronic pain management namely enhanced self-efficacy, motivation, empowerment, and social engagement. PMID:27090149

  19. A feasibility study evaluating Surgery for Mesothelioma After Radiation Therapy: the "SMART" approach for resectable malignant pleural mesothelioma.

    Science.gov (United States)

    Cho, B C John; Feld, Ron; Leighl, Natasha; Opitz, Isabelle; Anraku, Masaki; Tsao, Ming-Sound; Hwang, David M; Hope, Andrew; de Perrot, Marc

    2014-03-01

    We developed an innovative approach for malignant pleural mesothelioma (MPM) with a short accelerated course of high-dose hemithoracic intensity-modulated radiation therapy (IMRT) followed by extrapleural pneumonectomy (EPP). This phase I/II study assessed the feasibility of Surgery for Mesothelioma After Radiation Therapy (SMART). All resectable clinical T1-3N0M0 histologically proven, previously untreated MPMs were eligible. Patients received 25 Gy in five daily fractions during 1 week to the entire ipsilateral hemithorax with concomitant 5 Gy boost to areas at risk followed by EPP within 1 week of completing neoadjuvant IMRT. Adjuvant chemotherapy was offered to ypN2 patients on final pathologic findings. The primary end point was treatment-related mortality and secondary end points were overall survival, disease-free survival, treatment-related morbidity, and patterns of failure. Targeted accrual of 25 patients was completed between November 2008 and October 2012. All patients completed SMART. IMRT was well tolerated with no grade 3+ toxicities. EPP was performed 6 ± 2 days after completing IMRT without any perioperative mortality. Thirteen patients developed grade 3+ surgical complications. One patient (4%) died from treatment-related toxicity (empyema) during follow-up. All but one patient had stage III or IV disease on final pathologic findings. Five of 13 ypN2 patients received adjuvant chemotherapy. After a median follow-up of 23 months (range, 6-51), the cumulative 3-year survival reached 84% in epithelial subtypes compared with 13% in biphasic subtypes (p = 0.0002). SMART is feasible in resectable MPM patients. This innovative protocol presents encouraging results and supports future studies looking at long-term outcome in patients with epithelial subtypes.

  20. Feasibility study of ultrasound imaging for stereotactic body radiation therapy with active breathing coordinator in pancreatic cancer.

    Science.gov (United States)

    Su, Lin; Iordachita, Iulian; Zhang, Yin; Lee, Junghoon; Ng, Sook Kien; Jackson, Juan; Hooker, Ted; Wong, John; Herman, Joseph M; Sen, H Tutkun; Kazanzides, Peter; Lediju Bell, Muyinatu A; Yang, Chen; Ding, Kai

    2017-07-01

    Stereotactic body radiation therapy (SBRT) allows for high radiation doses to be delivered to the pancreatic tumors with limited toxicity. Nevertheless, the respiratory motion of the pancreas introduces major uncertainty during SBRT. Ultrasound imaging is a non-ionizing, non-invasive, and real-time technique for intrafraction monitoring. A configuration is not available to place the ultrasound probe during pancreas SBRT for monitoring. An arm-bridge system was designed and built. A CT scan of the bridge-held ultrasound probe was acquired and fused to ten previously treated pancreatic SBRT patient CTs as virtual simulation CTs. Both step-and-shoot intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) planning were performed on virtual simulation CT. The accuracy of our tracking algorithm was evaluated by programmed motion phantom with simulated breath-hold 3D movement. An IRB-approved volunteer study was also performed to evaluate feasibility of system setup. Three healthy subjects underwent the same patient setup required for pancreas SBRT with active breath control (ABC). 4D ultrasound images were acquired for monitoring. Ten breath-hold cycles were monitored for both phantom and volunteers. For the phantom study, the target motion tracked by ultrasound was compared with motion tracked by the infrared camera. For the volunteer study, the reproducibility of ABC breath-hold was assessed. The volunteer study results showed that the arm-bridge system allows placement of an ultrasound probe. The ultrasound monitoring showed less than 2 mm reproducibility of ABC breath-hold in healthy volunteers. The phantom monitoring accuracy is 0.14 ± 0.08 mm, 0.04 ± 0.1 mm, and 0.25 ± 0.09 mm in three directions. On dosimetry part, 100% of virtual simulation plans passed protocol criteria. Our ultrasound system can be potentially used for real-time monitoring during pancreas SBRT without compromising planning quality. The phantom study

  1. Effectiveness of speech language therapy either alone or with add-on computer-based language therapy software (Malayalam version) for early post stroke aphasia: A feasibility study.

    Science.gov (United States)

    Kesav, Praveen; Vrinda, S L; Sukumaran, Sajith; Sarma, P S; Sylaja, P N

    2017-09-15

    This study aimed to assess the feasibility of professional based conventional speech language therapy (SLT) either alone (Group A/less intensive) or assisted by novel computer based local language software (Group B/more intensive) for rehabilitation in early post stroke aphasia. Comprehensive Stroke Care Center of a tertiary health care institute situated in South India, with the study design being prospective open randomised controlled trial with blinded endpoint evaluation. This study recruited 24 right handed first ever acute ischemic stroke patients above 15years of age affecting middle cerebral artery territory within 90days of stroke onset with baseline Western Aphasia Battery (WAB) Aphasia Quotient (AQ) score of computer based language therapy in Group B over 4weeks on a thrice weekly basis, with a follow up WAB performed at four and twelve weeks after baseline assessment. The trial was registered with Clinical trials registry India [2016/08/0120121]. All the statistical analysis was carried out with IBM SPSS Statistics for Windows version 21. 20 subjects [14 (70%) Males; Mean age: 52.8years±SD12.04] completed the study (9 in the less intensive and 11 in the more intensive arm). The mean four weeks follow up AQ showed a significant improvement from the baseline in the total group (p value: 0.01). The rate of rise of AQ from the baseline to four weeks follow up (ΔAQ %) showed a significantly greater value for the less intensive treatment group as against the more intensive treatment group [155% (SD: 150; 95% CI: 34-275) versus 52% (SD: 42%; 95% CI: 24-80) respectively: p value: 0.053]. Even though the more intensive treatment arm incorporating combined professional based SLT and computer software based training fared poorer than the less intensive therapy group, this study nevertheless reinforces the feasibility of SLT in augmenting recovery of early post stroke aphasia. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Acceptance and Commitment Therapy in Daily Life Training: A Feasibility Study of an mHealth Intervention.

    Science.gov (United States)

    Batink, Tim; Bakker, Jindra; Vaessen, Thomas; Kasanova, Zuzana; Collip, Dina; van Os, Jim; Wichers, Marieke; Germeys, Inez; Peeters, Frenk

    2016-09-15

    With the development of mHealth, it is possible to treat patients in their natural environment. Mobile technology helps to bridge the gap between the therapist's office and the "real world." The ACT in Daily Life training (ACT-DL) was designed as an add-on intervention to help patients practice with acceptance and commitment therapy in their daily lives. The ACT-DL consists of two main components: daily monitoring using experience sampling and ACT training in daily life. To assess the acceptability and feasibility of the ACT-DL in a general outpatient population. A secondary objective was to conduct a preliminary examination of the effectiveness of the ACT-DL. An observational comparative study was conducted. The experimental group consisted of 49 patients who volunteered for ACT-DL, and the control group consisted of 112 patients who did not volunteer. As part of an inpatient treatment program, both groups received a 6-week ACT training. Participants went home to continue their treatment on an outpatient basis, during which time the experimental group received the 4-week add-on ACT-DL. Acceptability and feasibility of the ACT-DL was assessed weekly by telephone survey. Effectiveness of the ACT-DL was evaluated with several self-report questionnaires ( Flexibility Index Test (FIT-60): psychological flexibility, Brief Symptom Inventory: symptoms, Utrechtse Coping List: coping, and Quality of life visual analog scale (QoL-VAS): quality of life). More than three-quarters of the participants (76%) completed the full 4-week training. User evaluations showed that ACT-DL stimulated the use of ACT in daily life: participants practiced over an hour a week (mean 78.8 minutes, standard deviation 54.4), doing 10.4 exercises (standard deviation 6.0) on average. Both ACT exercises and metaphors were experienced as useful components of the training (rated 5 out of 7). Repeated measures ANCOVA did not show significant effects of the ACT-DL on psychological flexibility (P=.88

  3. Technical Feasibility of Acoustic Coordinated Reset Therapy for Tinnitus Delivered via Hearing Aids: A Case Study

    Directory of Open Access Journals (Sweden)

    Christian Hauptmann

    2017-01-01

    Full Text Available Primary tinnitus has a severe negative influence on the quality of life of a substantial portion of the general population. When acoustic coordinated reset (CR neuromodulation stimuli are delivered for several hours per day over several weeks a clinically significant symptom reduction in patients with primary tonal tinnitus has been reported by several clinical sites. Here, we reported the first case where CR neuromodulation was delivered through a hearing aid. A 52-year-old man with chronic primary tonal tinnitus was previously considered untreatable with sound therapy. He initially received the classic CR treatment protocol with signals delivered with the separate proprietary device with his hearing aids removed during treatment. He was subsequently treated with the therapy being deployed through a set of contemporary hearing aids. After 5 months of classic CR treatment with the separate custom device, the THI and VASL/A scores worsened by 57% and 13%/14%, respectively. Using the hearing aid without CR treatment for 5 months no change in tinnitus symptoms was observed. However, after three months of CR treatment delivered through the hearing aids, the THI and VASL/A scores were reduced by 70% and 32%/32%, respectively.

  4. Internet-based Cognitive Behavioral Therapy for Adolescents with Anxiety Disorders: A Feasibility Study

    DEFF Research Database (Denmark)

    Nielsen, Amalie; Gaardsvig, Majken Maria; Stjerneklar, Silke

    -17 years. Inclusion criteria were an anxiety disorder as primary diagnosis, access to a computer and the Internet at home, and ability to read and write in Danish. Exclusion criteria were comorbid depression (CSR ≥ 6), school absenteeism above 50%, self-harm, suicidal ideation, substance dependence......Aim Only a small proportion of children and adolescents with anxiety disorders receive treatment, despite evidence of the efficacy of CBT (cognitive behavioral therapy) (Reynolds, Wilson, Austin & Hooper, 2012). Lately there has been an increase in the development of ICBT (internet-based CBT......) programs to reduce costs and enhance accessibility of psychological interventions. ICBT has proven efficacious towards adults with anxiety disorders (Haug, Nordgreen, Ost & Havik, 2012; Reger & Gahm, 2009). Research in ICBT with children and adolescents is still in its infancy and no program targeting...

  5. Boron neutron capture therapy applied to advanced breast cancers: Engineering simulation and feasibility study of the radiation treatment protocol

    Science.gov (United States)

    Sztejnberg Goncalves-Carralves, Manuel Leonardo

    This dissertation describes a novel Boron Neutron Capture Therapy (BNCT) application for the treatment of human epidermal growth factor receptor type 2 positive (HER2+) breast cancers. The original contribution of the dissertation is the development of the engineering simulation and the feasibility study of the radiation treatment protocol for this novel combination of BNCT and HER2+ breast cancer treatment. This new concept of BNCT, representing a radiation binary targeted treatment, consists of the combination of two approaches never used in a synergism before. This combination may offer realistic hope for relapsed and/or metastasized breast cancers. This treatment assumes that the boronated anti-HER2 monoclonal antibodies (MABs) are administrated to the patient and accumulate preferentially in the tumor. Then the tumor is destroyed when is exposed to neutron irradiation. Since the use of anti-HER2 MABs yields good and promising results, the proposed concept is expected to amplify the known effect and be considered as a possible additional treatment approach to the most severe breast cancers for patients with metastasized cancer for which the current protocol is not successful and for patients refusing to have the standard treatment protocol. This dissertation makes an original contribution with an integral numerical approach and proves feasible the combination of the aforementioned therapy and disease. With these goals, the dissertation describes the theoretical analysis of the proposed concept providing an integral engineering simulation study of the treatment protocol. An extensive analysis of the potential limitations, capabilities and optimization factors are well studied using simplified models, models based on real CT patients' images, cellular models, and Monte Carlo (MCNP5/X) transport codes. One of the outcomes of the integral dosimetry assessment originally developed for the proposed treatment of advanced breast cancers is the implementation of BNCT

  6. Bio-sheet graft therapy for artificial gastric ulcer after endoscopic submucosal dissection: an animal feasibility study.

    Science.gov (United States)

    Kwon, Chang-Il; Kim, Gwangil; Ko, Kwang Hyun; Jung, Yunho; Chung, Il-Kwun; Jeong, Seok; Lee, Don Haeng; Hong, Sung Pyo; Hahm, Ki Baik

    2015-04-01

    Various bio-sheet grafts have been attempted either to accelerate healing of artificial ulcers or to prevent adverse events after endoscopic submucosal dissection (ESD), but neither prospective nor mechanistic studies were available. To evaluate the substantial effect of a bio-sheet graft on artificial ulcer healing and its feasibility as an endoscopic treatment modality. Preclinical, in vivo animal experiment and proof-of-concept study. Animal laboratory. Three mini-pigs, Sus scrofa, mean age 14 months. Multiple ulcers sized 2.5 cm in diameter were generated by ESD in 3 mini-pigs and were assigned randomly into the following 3 groups; control group, bio-sheet group, or combination (bio-sheet plus drug) group. Bio-sheet grafts or bio-sheet plus drug combinations were applied on the artificial ulcers immediately after the ESD. Feasibility and efficacy of endoscopic bio-sheet graft therapy for the management of artificial ulcers and the evaluation of healing conditions based on histology changes in the remaining gastric bed tissues harvested from the stomachs. Thirty-three ESD specimens were obtained. On an image analysis of the ratio of healed area in the remaining gastric bed tissue compared with the matched dissected gastric mucosa, the control group showed the most significant improvement in healing activity among the 3 groups (P ulcer tissue was significantly attenuated in bio-sheet and combination groups (P gastric acid attack as reflected in the attenuated inflammation on the ulcer beds, unexpected delayed ulcer healing was noted in the bio-sheet graft group because of its physical hindrance of the healing process. Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  7. Adding physical therapy services in the emergency department to prevent immobilization syndrome - a feasibility study in a university hospital.

    Science.gov (United States)

    Tousignant-Laflamme, Yannick; Beaudoin, Ann-Marie; Renaud, Anne-Marie; Lauzon, Stephanie; Charest-Bossé, Marie-Catherine; Leblanc, Louise; Grégoire, Maryse

    2015-12-03

    The association between the functional decline occurring with bedrest and hospitalization in older persons is well-known. A long wait in the emergency department (ED), where patients can be bedridden, is a risk factor for the development of an immobilization syndrome (IS). IS is one of the unwanted consequences of inactivity, which causes pathological changes in most organs and systems. Early mobility interventions, such as physical therapy (PT) delivered in the ED, may prevent its development. To our knowledge, no prior studies have reported on this topic. The goal of this study was to (i) assess the feasibility and (ii) explore the potential clinical value of adding PT services to the ED, in collaboration with nursing staff, to prevent IS. For 12 weeks, PT services were delivered in the ED to older persons (>65 years old) presenting with ≥1 clinical signs associated with the development of IS. Patients were screened by ED nurses and then seen by the physiotherapist. In order to assess feasibility, access to patients, percentage of patients who met eligibility criteria, acceptability of the intervention, and barriers/facilitators to the implementation were measured. To describe the clinical benefits of early PT services, we counted the number of new IS cases among patients after their admission to the ward. After 12 weeks, the ED nurses screened 187 potential patients and 20 received PT services in the ED (before their admission to the ward). Accessibility was not an issue and we observed good acceptability from the milieu. We did not find majors problems or insurmountable obstacles to implementation of the intervention. Clinical outcomes showed that nine patients received PT treatments in the ED and on the ward (after their admission). For the 11 other patients, no PT interventions were done in the ED following the assessment. Follow-up of these 11 patients showed that two of them developed IS during their hospital stay. As for the nine patients who began

  8. Feasibility of using interstitial ultrasound for intradiscal thermal therapy: a study in human cadaver lumbar discs

    Energy Technology Data Exchange (ETDEWEB)

    Nau, William H; Diederich, Chris J; Shu, Richard [Thermal Therapy Research Group, Department of Radiation Oncology, University of California, San Francisco, CA (United States)

    2005-06-21

    Application of heat in the spine using resistive wire heating devices is currently being used clinically for minimally invasive treatment of discogenic low back pain. In this study, interstitial ultrasound was evaluated for the potential to heat intradiscal tissue more precisely by directing energy towards the posterior annular wall while avoiding vertebral bodies. Two single-element directional applicator design configurations were tested: a 1.5 mm OD direct-coupled (DC) applicator which can be implanted directly within the disc, and a catheter-cooled (CC) applicator which is inserted in a 2.4 mm OD catheter with integrated water cooling and implanted within the disc. The transducers were sectored to produce 90 deg. spatial heating patterns for directional control. Both applicator configurations were evaluated in four human cadaver lumbar disc motion segments. Two heating protocols were employed in this study in which the temperature measured 5 mm away from the applicator was controlled to either T = 52 deg. C, or T > 70 deg. C for the treatment period. These temperatures (thermal doses) are representative of those required for thermal necrosis of in-growing nociceptor nerve fibres and disc cellularity alone, or with coagulation and restructuring of annular collagen in the high-temperature case. Steady-state temperature maps, and thermal doses (t{sub 43}) were used to assess the thermal treatments. Results from these studies demonstrated the capability of controlling temperature distributions within selected regions of the disc and annular wall using interstitial ultrasound, with minimal vertebral end-plate heating. While directional heating was demonstrated with both applicator designs, the CC configuration had greater directional heating capabilities and offered better temperature control than the DC configuration, particularly during the high-temperature protocol. Further, ultrasound energy was capable of penetrating within the highly attenuating disc tissue to

  9. Feasibility of using interstitial ultrasound for intradiscal thermal therapy: a study in human cadaver lumbar discs

    Science.gov (United States)

    Nau, William H.; Diederich, Chris J.; Shu, Richard

    2005-06-01

    Application of heat in the spine using resistive wire heating devices is currently being used clinically for minimally invasive treatment of discogenic low back pain. In this study, interstitial ultrasound was evaluated for the potential to heat intradiscal tissue more precisely by directing energy towards the posterior annular wall while avoiding vertebral bodies. Two single-element directional applicator design configurations were tested: a 1.5 mm OD direct-coupled (DC) applicator which can be implanted directly within the disc, and a catheter-cooled (CC) applicator which is inserted in a 2.4 mm OD catheter with integrated water cooling and implanted within the disc. The transducers were sectored to produce 90° spatial heating patterns for directional control. Both applicator configurations were evaluated in four human cadaver lumbar disc motion segments. Two heating protocols were employed in this study in which the temperature measured 5 mm away from the applicator was controlled to either T = 52 °C, or T > 70 °C for the treatment period. These temperatures (thermal doses) are representative of those required for thermal necrosis of in-growing nociceptor nerve fibres and disc cellularity alone, or with coagulation and restructuring of annular collagen in the high-temperature case. Steady-state temperature maps, and thermal doses (t43) were used to assess the thermal treatments. Results from these studies demonstrated the capability of controlling temperature distributions within selected regions of the disc and annular wall using interstitial ultrasound, with minimal vertebral end-plate heating. While directional heating was demonstrated with both applicator designs, the CC configuration had greater directional heating capabilities and offered better temperature control than the DC configuration, particularly during the high-temperature protocol. Further, ultrasound energy was capable of penetrating within the highly attenuating disc tissue to produce more

  10. Whole-body vibration therapy in intensive care patients: A feasibility and safety study.

    Science.gov (United States)

    Boeselt, Tobias; Nell, Christoph; Kehr, Katahrina; Holland, Angélique; Dresel, Marc; Greulich, Timm; Tackenberg, Björn; Kenn, Klaus; Boeder, Johannes; Klapdor, Benjamin; Kirschbaum, Andreas; Vogelmeier, Claus; Alter, Peter; Koczulla, Andreas Rembert

    2016-03-01

    Admission to the intensive care unit is associated with sustained loss of muscle mass, reduced quality of life and increased mortality. Early rehabilitation measures may counteract this process. New approaches to rehabilitation while the patient remains in bed are whole-body vibration alone and whole-body vibration with a dumbbell. The aims of this study are to determine the safety of whole-body vibration for patients admitted to the intensive care unit, and to compare the effects of these techniques in intensive care unit patients and healthy subjects. Twelve intensive care unit patients and 12 healthy subjects using whole-body vibration for the first time were examined while lying in bed. First both groups performed whole body vibration over 3 min. In a second step whole body vibration with dumbbell was performed. In order to determine the safety of the training intensity, heart rate, oxygen saturation and blood pressure were measured. The study was approved by the Marburg ethics committee. There were minor reversible and transient increases in diastolic blood pressure (p = 0.005) and heart rate (p = 0.001) in the control group with whole-body vibration with a dumbbell. In intensive care patients receiving whole-body vibration alone, there were increases in diastolic blood pressure (p = 0.011) and heart rate (p vibration and whole-body vibration with a dumbbell for intensive care unit in-bed patients. No clinically significant safety problems were found. Whole-body vibration and whole-body vibration with a dumbbell might therefore be alternative methods for use in early in-bed rehabilitation, not only for hospitalized patients.

  11. Effects of Healing Touch and Relaxation Therapy on Adult Patients Undergoing Hematopoietic Stem Cell Transplant: A Feasibility Pilot Study.

    Science.gov (United States)

    Lu, Der-Fa; Hart, Laura K; Lutgendorf, Susan K; Oh, Hyunkyoung; Silverman, Margarida

    2016-01-01

    Stem cell transplant (SCT), considered the current standard of care for adults with advanced cancers, can lead to substantial deconditioning and diminished well-being. Attending to life quality of SCT recipients is now viewed as essential. The objective of this study was to identify the feasibility and preliminary efficacy of healing touch (HT) and relaxation therapy (RT) with patients undergoing SCT. A randomized prospective design compared 13 SCT patients who received HT daily while hospitalized to 13 similar SCT patients who received daily RT. The clinical outcomes of the 2 groups were also compared with retrospective clinical data of 20 patients who received SCT during the same year. The mean age of participants was 57 years, with 54% receiving autologous and 46% receiving allogeneic transplants. All patients assigned to the HT group completed the protocol. Only 60% of the relaxation group completed the intervention. Both interventions produced improvement in psychosocial measures and a shorter hospital length of stay (LOS) than the historical group. Differential results for LOS were related to the type of transplant received. The LOS differences were not statistically significant but could be clinically significant. Healing touch was a better tolerated modality by this population. Future research is needed to validate the LOS advantage of the HT and RT interventions, explore the differences in effect found with different transplant types, and identify patients who can tolerate RT. The LOS reduction could result in decreased cost. Second, mood and function improvements support quality of life during SCT treatment.

  12. Communication Bridge: A pilot feasibility study of Internet-based speech-language therapy for individuals with progressive aphasia.

    Science.gov (United States)

    Rogalski, Emily J; Saxon, Marie; McKenna, Hannah; Wieneke, Christina; Rademaker, Alfred; Corden, Marya E; Borio, Kathryn; Mesulam, M-Marsel; Khayum, Becky

    2016-11-01

    Individuals with aphasia symptoms due to neurodegenerative dementia are under-referred for speech-language therapy (SLT) services. We sought to determine the feasibility of utilizing telepractice, via Internet video conferencing, to connect an individual with progressive aphasia due to dementia to a speech-language pathologist for treatment. Participants received an Initial Evaluation, 8 person-centered Internet-based SLT sessions and two Post-Therapy Evaluations. The feasibility of providing web-based SLT, strategies used and their compliance, functional gains and the duration of benefit were assessed. Thirty-four participants from 21 states and Canada were enrolled. Thirty-one participants completed the 6-month Evaluation. Speech-language pathologist-assessed and self-reported functional gains, as well as increased confidence in communication were documented at 2-months and maintained at 6-months post-enrollment. Internet-based SLT using person-centered interventions provides a feasible model for delivering care to individuals with dementia and mild/moderate aphasia symptoms who have an engaged care-partner and prior familiarity with a computer.

  13. Feasibility and acceptability of two incentive-based implementation strategies for mental health therapists implementing cognitive-behavioral therapy: a pilot study to inform a randomized controlled trial.

    Science.gov (United States)

    Beidas, Rinad S; Becker-Haimes, Emily M; Adams, Danielle R; Skriner, Laura; Stewart, Rebecca E; Wolk, Courtney Benjamin; Buttenheim, Alison M; Williams, Nathaniel J; Inacker, Patricia; Richey, Elizabeth; Marcus, Steven C

    2017-12-15

    Informed by our prior work indicating that therapists do not feel recognized or rewarded for implementation of evidence-based practices, we tested the feasibility and acceptability of two incentive-based implementation strategies that seek to improve therapist adherence to cognitive-behavioral therapy for youth, an evidence-based practice. This study was conducted over 6 weeks in two community mental health agencies with therapists (n = 11) and leaders (n = 4). Therapists were randomized to receive either a financial or social incentive if they achieved a predetermined criterion on adherence to cognitive-behavioral therapy. In the first intervention period (block 1; 2 weeks), therapists received the reward they were initially randomized to if they achieved criterion. In the second intervention period (block 2; 2 weeks), therapists received both rewards if they achieved criterion. Therapists recorded 41 sessions across 15 unique clients over the project period. Primary outcomes included feasibility and acceptability. Feasibility was assessed quantitatively. Fifteen semi-structured interviews were conducted with therapists and leaders to assess acceptability. Difference in therapist adherence by condition was examined as an exploratory outcome. Adherence ratings were ascertained using an established and validated observational coding system of cognitive-behavioral therapy. Both implementation strategies were feasible and acceptable-however, modifications to study design for the larger trial will be necessary based on participant feedback. With respect to our exploratory analysis, we found a trend suggesting the financial reward may have had a more robust effect on therapist adherence than the social reward. Incentive-based implementation strategies can be feasibly administered in community mental health agencies with good acceptability, although iterative pilot work is essential. Larger, fully powered trials are needed to compare the effectiveness of

  14. Acceptance and commitment therapy for adults with advanced cancer (CanACT): study protocol for a feasibility randomised controlled trial.

    Science.gov (United States)

    Low, Joseph; Serfaty, Marc; Davis, Sarah; Vickerstaff, Victoria; Gola, Anna; Omar, Rumana Z; King, Michael; Tookman, Adrian; Austen, Janet St John; Turner, Karen; Jones, Louise

    2016-02-11

    One-third of people with cancer experience psychological distress and may suppress distressing thoughts, emotions, and concerns, leading to further problems. Conventional psychological treatments reduce distress by problem solving, but in advanced cancer, when ill health is progressive and death may be approaching, physical and psychological difficulties are complex and have no simple solutions. Acceptance and Commitment Therapy encourages acknowledgement and acceptance of mental experiences, increasing people's ability to work with problems that cannot be solved. Previous pilot work in advanced cancer confirms that distress can be associated with an avoidance of experiencing uncomfortable thoughts and emotions. This feasibility randomised controlled trial of Acceptance Commitment Therapy aims to establish parameters for a larger trial. Fifty-four participants with advanced cancer will be randomly allocated to up to eight sessions (each 1 hour) of Acceptance Commitment Therapy or a talking control. Participants will be recruited from those attending outpatient services and hospice day care at three specialist palliative care units in North and East London, United Kingdom. The primary outcome is a measure of functioning in four areas of life (physical, social/family, emotional, and general activity) using the Functional Assessment of Cancer Therapies--General questionnaire at 3 months after randomisation. Secondary outcomes are (i) acceptance using the Acceptance and Action Questionnaire; (ii) psychological distress using the Kessler Psychological Distress Scale; (iii) physical functioning using a timed walk and sit-to-stand test; and (iv) quality of life measures including the Euroqol-5 Dimensions and ICECAP Supportive Care measures. Qualitative data will be collected at 3 months to explore the participants' experiences of the trial and therapy. Data will be collected on the costs of care. Data generated on the recruitment, retention, and experience of the

  15. Feasibility studies and technological innovation

    DEFF Research Database (Denmark)

    Hvelplund, Frede Kloster; Lund, Henrik; Sukkumnoed, Decharut

    2004-01-01

    The chapter offers a tool to conduct feasibility studies and focuses on how to make feasibility studies in a situation with environmental concerns, in which technological innovation and institutional chnages are among the objectives.......The chapter offers a tool to conduct feasibility studies and focuses on how to make feasibility studies in a situation with environmental concerns, in which technological innovation and institutional chnages are among the objectives....

  16. A feasibility pilot study on the use of complementary therapies delivered via mobile technologies on Icelandic surgical patients? reports of anxiety, pain, and self-efficacy in healing

    OpenAIRE

    Hansen, Margaret M

    2015-01-01

    Background Complementary therapies (CT), such as relaxation technique, massage, guided imagery, and accupuncture have shown to benefit patients undergoing surgery. The aim of this study was to determine the feasibility of using audio relaxation technique (ART), music intervention (MI), nature video application with music (NVAM), and nature video application without music (NVA) delivered via mobile technologies in a clinical setting. Secondary, the effects of ART, MI, NVAM and NVA on patients?...

  17. Feasibility of mindfulness-based therapy in patients recovering from a first psychotic episode: a pilot study

    NARCIS (Netherlands)

    van der Valk, Renate; van de Waerdt, Susanna; Meijer, Carin J.; van den Hout, Ingrid; de Haan, Lieuwe

    2013-01-01

    Recently, a mindfulness therapy for people with psychotic disorders was developed. However, clinicians and researchers are cautious given case reports in which extensive meditation provoked psychotic symptoms in people with a psychotic disorder. The purpose of this study was to examine the

  18. Polymersomes as nano-carriers to retain harmful recoil nuclides in alpha radionuclide therapy. A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Thijssen, L.; Schaart, D.R.; Vries, D. de; Denkova, A.G. [Delft Univ. of Technology (Netherlands). Radiation, Radionuclides and Reactors; Morgenstern, A.; Bruchertseifer, F. [European Commission, Joint Research Centre, Karlsruhe (Germany). Inst. for Transuranium Elements

    2012-07-01

    Targeted alpha therapy has shown promising pre-clinical and clinical results in the fight against cancer. The use of in vivo generators, generating a highly cytotoxic cascade of alpha particles, is attracting increasing interest for clinical application. {sup 225}Ac is one of the nuclides that can serve as an in vivo generator. It is commercially available and provides four alpha particles with a total energy of 28 MeV per {sup 225}Ac decay. However, its alpha emitting daughter nuclides may escape from the target region due to recoil and cause unwanted toxicity in other parts of the body. In this paper, we investigate the feasibility of designing spherical, block-copolymer based nano-carriers (polymersomes) to retain the recoiling daughter nuclides. A Monte Carlo code, called NANVES, has been developed to simulate the range distributions of recoil atoms in different materials and to determine the optimum nano-carriers design. Recoil ranges in planar polystyrene films were determined experimentally and compared to simulations of the experiment, indicating that NANVES may provide accurate results. Simulations of various nano-carriers designs indicate that double-layered polymersomes with a diameter of 800 nm are capable of completely retaining the first daughter nuclide {sup 221}Fr, while the escape fraction of the third radioactive daughter {sup 213}Bi is reduced to 20% and the percentage of alpha particles emitted from escaped daughter products outside the nano-carriers is less than 10%. (orig.)

  19. High-intensity sports for posttraumatic stress disorder and depression: feasibility study of ocean therapy with veterans of Operation Enduring Freedom and Operation Iraqi Freedom.

    Science.gov (United States)

    Rogers, Carly M; Mallinson, Trudy; Peppers, Dominique

    2014-01-01

    In this study, we conducted a pretest-posttest investigation of a sports-oriented occupational therapy intervention using surfing in an experiential, skills-based program to support veterans with symptoms of posttraumatic stress disorder (PTSD) in their transition to civilian life. The purpose of this feasibility study was to evaluate the intervention for attendance rates and retention in the program provided in 5 sessions over 5 wk. Fourteen veterans from a specialty postdeployment clinic at a Veterans Affairs hospital were enrolled; 11 completed the study, and 10 attended ≥3 sessions. Participants reported clinically meaningful improvement in PTSD symptom severity (PTSD Checklist-Military Version, Wilcoxon signed rank Z = 2.5, p = .01) and in depressive symptoms (Major Depression Inventory, Wilcoxon signed rank Z = 2.05, p = .04). The results of this small, uncontrolled study suggest that a sports-oriented occupational therapy intervention has potential as a feasible adjunct intervention for veterans seeking mental health treatment for symptoms of PTSD. Copyright © 2014 by the American Occupational Therapy Association, Inc.

  20. Combined Cognitive-Behavioural and Physiotherapeutic Therapy for Patients with Chronic Pelvic Pain Syndrome (COMBI-CPPS): study protocol for a controlled feasibility trial.

    Science.gov (United States)

    Brünahl, Christian A; Klotz, Susanne G R; Dybowski, Christoph; Riegel, Björn; Gregorzik, Sonja; Tripp, Dean A; Ketels, Gesche; Löwe, Bernd

    2018-01-09

    Chronic pelvic pain syndrome (CPPS) is a pain condition perceived in the pelvic area for at least 6 months. While evidence of the aetiology and maintenance of CPPS is still unclear and therapy options are rare, there is preliminary evidence for the efficacy of cognitive behavioural therapy and physiotherapy. However, an integrated treatment has not yet been studied. The primary aim of this study is therefore to test the feasibility of combined psychotherapy and physiotherapy for female and male patients with CPPS. The secondary aim is to explore changes in patient-relevant and economic outcomes compared to a control group. A feasibility study with a crossover design based on the principles of a 'cohort multiple randomized controlled trial' will be conducted to test a combined therapy for patients with CPPS. The study will consist of two consecutive treatment modules (cognitive behavioural group psychotherapy and physiotherapy as individual and group sessions), which will be applied in varying order. The modules will consist of nine weekly sessions with a 4-week break between the modules. The control group will undergo treatment as usual. Study subjects will be recruited from the interdisciplinary outpatient clinic for CPPS at the University Medical Center Hamburg-Eppendorf. Thirty-six patients will be assigned to the intervention, and 18 patients will be assigned to the control group. The treatment groups will be gender homogeneous. Feasibility as the primary outcome will be analysed in terms of the demand, acceptability, and practicality. Secondary study outcomes will be measured using validated self-rating-scales and physical examinations. To the best of our knowledge, this study is the first to investigate the feasibility of combined psychotherapy and physiotherapy for patients with CPPS. In addition to testing feasibility, the results can be used for the preliminary estimation of therapeutic effects. The results from this study will be used to generate an

  1. GINGER: A feasibility study

    Science.gov (United States)

    Di Virgilio, Angela D. V.; Belfi, Jacopo; Ni, Wei-Tou; Beverini, Nicolo; Carelli, Giorgio; Maccioni, Enrico; Porzio, Alberto

    2017-04-01

    GINGER (Gyroscopes IN General Relativity) is a proposal for an Earth-based experiment to measure the Lense-Thirring (LT) and de Sitter effects. GINGER is based on ring lasers, which are the most sensitive inertial sensors to measure the rotation rate of the Earth. We show that two ring lasers, one at maximum signal and the other horizontal, would be the simplest configuration able to retrieve the GR effects. Here, we discuss this configuration in detail showing that it would have the capability to test LT effect at 1%, provided the accuracy of the scale factor of the instrument at the level of 1 part in 1012 is reached. In principle, one single ring laser could do the test, but the combination of the two ring lasers gives the necessary redundancy and the possibility to verify that the systematics of the lasers are sufficiently small. The discussion can be generalised to seismology and geodesy and it is possible to say that signals 10-12 orders of magnitude below the Earth rotation rate can be studied; the proposed array can be seen as the basic element of multi-axial systems, and the generalisation to three dimensions is feasible adding one or two devices and monitoring the relative angles between different ring lasers. This simple array can be used to measure with very high precision the amplitude of angular rotation rate (the length of the day, LOD), its short term variations, and the angle between the angular rotation vector and the horizontal ring laser. Finally this experiment could be useful to probe gravity at fundamental level giving indications on violations of Einstein Equivalence Principle and Lorenz Invariance and possible chiral effects in the gravitational field.

  2. Delivery of Intensive Voice Therapy for Vocal Fold Nodules Via Telepractice: A Pilot Feasibility and Efficacy Study.

    Science.gov (United States)

    Fu, Sherry; Theodoros, Deborah G; Ward, Elizabeth C

    2015-11-01

    This pilot study examined voice outcomes and patient perceptions after intensive voice therapy for vocal fold nodules via telepractice. Pilot, within-subjects experimental trial. Participants included 10 women diagnosed with bilateral vocal fold nodules who received intensive voice treatment via a free videoconferencing platform Skype, (Microsoft Corp., Redmond, WA). All participants completed one vocal hygiene session in person, followed by eight sessions of therapy via telepractice over 3 weeks. Before and immediately after treatment, patients attended a clinic in person to complete perceptual, stroboscopic, acoustic, and physiological assessments of vocal function. Analyses were performed by a speech-language pathologist and an otolaryngologist independent to and blinded to the study. Participants also completed the Voice Handicap Index and a telepractice satisfaction questionnaire, or an anticipated satisfaction questionnaire, before and after the treatment. Significant improvements were found in perceptual, vocal fold function, acoustic, and physiological parameters as well as nodule sizes and patient perceptions of voice-related quality of life post-treatment. Participants were highly positive about their first experience with telepractice. Results were similar to those from a separate study investigating the effects of an intensive voice therapy delivered in conventional face-to-face (FTF) format. This study is consistent with possible benefits of telepractice in the delivery of intensive treatment for vocal fold nodules. Pending final verification with a FTF comparison group, telepractice could be recommended as an alternate treatment modality for patients with vocal fold nodules. Copyright © 2015 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  3. SU-E-T-421: Feasibility Study of Volumetric Modulated Arc Therapy with Constant Dose Rate for Endometrial Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Yang, R; Wang, J [Peking University Third Hospital, Beijing, Beijing (China)

    2014-06-01

    Purpose: To investigate the feasibility, efficiency, and delivery accuracy of volumetric modulated arc therapy with constant dose rate (VMAT-CDR) for whole-pelvic radiotherapy (WPRT) of endometrial cancer. Methods: The nine-Field intensity-modulated radiotherapy (IMRT), VMAT with variable dose-rate (VMAT-VDR), and VMAT-CDR plans were created for 9 patients with endometrial cancer undergoing WPRT. The dose distribution of planning target volume (PTV), organs at risk (OARs), and normal tissue (NT) were compared. The monitor units (MUs) and treatment delivery time were also evaluated. For each VMAT-CDR plan, a dry Run was performed to assess the dosimetric accuracy with MatriXX from IBA. Results: Compared with IMRT, the VMAT-CDR plans delivered a slightly greater V20 of the bowel, bladder, pelvis bone, and NT, but significantly decreased the dose to the high-dose region of the rectum and pelvis bone. The MUs Decreased from 1105 with IMRT to 628 with VMAT-CDR. The delivery time also decreased from 9.5 to 3.2 minutes. The average gamma pass rate was 95.6% at the 3%/3 mm criteria with MatriXX pretreatment verification for 9 patients. Conclusion: VMAT-CDR can achieve comparable plan quality with significant shorter delivery time and smaller number of MUs compared with IMRT for patients with endometrial cancer undergoing WPRT. It can be accurately delivered and be an alternative to IMRT on the linear accelerator without VDR capability. This work is supported by the grant project, National Natural; Science Foundation of China (No. 81071237)

  4. Evaluation of the effectiveness of music therapy in improving the quality of life of palliative care patients: a randomised controlled pilot and feasibility study.

    Science.gov (United States)

    McConnell, Tracey; Graham-Wisener, Lisa; Regan, Joan; McKeown, Miriam; Kirkwood, Jenny; Hughes, Naomi; Clarke, Mike; Leitch, Janet; McGrillen, Kerry; Porter, Sam

    2016-01-01

    Music therapy is frequently used as a palliative therapy. In consonance with the goals of palliative care, the primary aim of music therapy is to improve people's quality of life by addressing their psychological needs and facilitating communication. To date, primarily because of a paucity of robust research, the evidence for music therapy's effectiveness on patient reported outcomes is positive but weak. This pilot and feasibility study will test procedures, outcomes and validated tools; estimate recruitment and attrition rates; and calculate the sample size required for a phase III randomised trial to evaluate the effectiveness of music therapy in improving the quality of life of palliative care patients. A pilot randomised controlled trial supplemented with qualitative methods. The quantitative data collection will involve recruitment of >52 patients from an inpatient Marie Curie hospice setting over a 12-month period. Eligibility criteria include all patients with an Eastern Cooperative Oncology Group (ECOG) performance status of 03- indicating they are medically fit to engage with music therapy and an Abbreviated Mental Test (AMT) score of ≥7 indicating they are capable of providing meaningful informed consent and accurate responses to outcome measures. Baseline data collection will include the McGill Quality of Life Questionnaire (MQOL); medical and socio-demographic data will be undertaken before randomisation to an intervention or control group. Participants in the intervention arm will be offered two 30-45 min sessions of music therapy per week for three consecutive weeks, in addition to care as usual. Participants in the control arm will receive care as usual. Follow-up measures will be administered in 1, 3 and 5 weeks. Qualitative data collection will involve focus group and individual interviews with HCPs and carers. This study will ensure a firm methodological grounding for the development of a robust phase III randomised trial of music therapy for

  5. Feasibility and results of a randomised pilot-study of pre-discharge occupational therapy home visits

    Directory of Open Access Journals (Sweden)

    Lin Chung-Wei

    2007-03-01

    Full Text Available Abstract Background Pre-discharge home visits aim to maximise independence in the community. These visits involve assessment of a person in their own home prior to discharge from hospital, typically by an occupational therapist. The therapist may provide equipment, adapt the home environment and/or provide education. The aims of this study were to investigate the feasibility of a randomised controlled trial in a clinical setting and the effect of pre-discharge home visits on functional performance in older people undergoing rehabilitation. Methods Ten patients participating in an inpatient rehabilitation program were randomly assigned to receive either a pre-discharge home visit (intervention, or standard practice in-hospital assessment and education (control, both conducted by an occupational therapist. The pre-discharge home visit involved assessment of the older person's function and environment, and education, and took an average of 1.5 hours. The hospital-based interview took an average of 40 minutes. Outcome data were collected by a blinded assessor at 0, 2, 4, 8 and 12 weeks. Outcomes included performance of activities of daily living, reintegration to community living, quality of life, readmission and fall rates. Results Recruitment of 10 participants was slow and took three months. Observed performance of functional abilities did not differ between groups due to the small sample size. Difference in activities of daily living participation, as recorded by the Nottingham Extended Activities of Daily Living scale, was statistically significant but wide confidence intervals and low statistical power limit interpretation of results. Conclusion Evaluation of pre-discharge home visits by occupational therapists in a rehabilitation setting is feasible, but a more effective recruitment strategy for a main study is favored by application of a multi-centre setting.

  6. TechCare: mobile assessment and therapy for psychosis – an intervention for clients in the Early Intervention Service: A feasibility study protocol

    Directory of Open Access Journals (Sweden)

    Nusrat Husain

    2016-10-01

    Full Text Available Objectives: Technological advances in healthcare have shown promise when delivering interventions for mental health problems such as psychosis. The aim of this project is to develop a mobile phone intervention for people with psychosis and to conduct a feasibility study of the TechCare App. Methods: The TechCare App will assess participant’s symptoms and respond with a personalised guided self-help-based psychological intervention with the aim of exploring feasibility and acceptability. The project will recruit 16 service users and 8–10 health professionals from the Lancashire Care NHS Foundation Trust Early Intervention Service. Results: In strand 1 of the study, we will invite people to discuss their experience of psychosis and give their opinions on the existing evidence-based treatment (cognitive behavioural therapy and how the mobile app can be developed. In strand 2, we will complete a test run with a small number of participants (n = 4 to refine the mobile intervention (TechCare. Finally, in strand 3 of the study, the TechCare App will be examined in a feasibility study with 12 participants. Conclusion: It has been suggested that there is a need for a rapid increase in the efforts to develop the evidence base for the clinical effectiveness of digital technologies, considering mHealth research can potentially be helpful in addressing the demand on mental health services globally.

  7. SU-E-T-419: Fabricating Cerrobend Grids with 3D Printing for Spatially Modulated Radiation Therapy: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, X; Driewer, J; Lei, Y; Zheng, D; Li, S; Zhang, Q; Zhang, M; Zhou, S [University of Nebraska Medical Center, Omaha, NE (United States); Cullip, T; Chang, S [UNC Hospitals, Chapel Hill, NC (United States)

    2015-06-15

    Purpose: Grid therapy has promising applications in the radiation treatment of bulky and large tumors. However, research and applications of grid therapy is limited by the accessibility of the specialized blocks that produce the grid of pencil-like radiation beams. In this study, a Cerrobend grid block was fabricated using a 3D printing technique. Methods: A grid block mold was designed with divergent tubes following beam central rays. The mold was printed using a resin with the working temperature below 230 °C. The melted Cerrobend liquid at 120°oC was cast into the resin mold to yield a block with a thickness of 7.4 cm. The grid had a hexagonal pattern, with each pencil beam diameter of 1.4 cm at the iso-center plane; the distance between the beam centers was 2 cm. The dosimetric properties of the grid block were studied using radiographic film and small field dosimeters. Results: the grid block was fabricated to be mounted at the third accessory mount of a Siemens Oncor linear accelerator. Fabricating a grid block using 3D printing is similar to making cutouts for traditional radiotherapy photon blocks, with the difference being that the mold was created by a 3D printer rather than foam. In this study, the valley-to-peak ratio for a 6MV photon grid beam was 20% at dmax, and 30% at 10 cm depth, respectively. Conclusion: We have demonstrated a novel process for implementing grid radiotherapy using 3D printing techniques. Compared to existing approaches, our technique combines reduced cost, accessibility, and flexibility in customization with efficient delivery. This lays the groundwork for future studies to improve our understanding of the efficacy of grid therapy and apply it to improve cancer treatment.

  8. Catheter-directed Intraportal Delivery of Endothelial Cell Therapy for Liver Regeneration: A Feasibility Study in a Large-Animal Model of Cirrhosis.

    Science.gov (United States)

    Lee, Kyungmouk Steve; Santagostino, Sara F; Li, David; Ramjit, Amit; Serrano, Kenneth; Ginsberg, Michael D; Ding, Bi-Sen; Rafii, Shahin; Madoff, David C

    2017-10-01

    Purpose To demonstrate the feasibility of imaging-guided catheter-directed delivery of endothelial cell therapy in a porcine model of cirrhosis for liver regeneration. Materials and Methods After approval from the institutional animal care and use committee, autologous liver endothelial cells were grown from core hepatic specimens from swine. Cirrhosis was induced in swine by means of transcatheter infusion of ethanol and iodized oil into the hepatic artery. Three weeks after induction of cirrhosis, the swine were randomly assigned to receive autologous cell therapy (endothelial cells, n = 4) or control treatment (phosphate-buffered saline, n = 4) by means of imaging-guided transhepatic intraportal catheterization. Fluorescence-activated cell sorting analysis was performed on biopsy samples 1 hour after therapy. Three weeks after intraportal delivery of endothelial cells, the swine were euthanized and the explanted liver underwent quantitative pathologic examination. Statistical analysis was performed with an unpaired t test by using unequal variance. Results Liver endothelial cells were successfully isolated, cultured, and expanded from eight 20-mm, 18-gauge hepatic core samples to 50 × 106 autologous cells per pig. Intraportal delivery of endothelial cell therapy or saline was technically successful in all eight swine, with no complications. Endothelial cells were present in the liver for a minimum of 1 hour after intraportal infusion. Swine treated with endothelial cell therapy showed mean levels of surrogate markers of hepatobiliary injury that were consistent with decreases in hepatic fibrosis and biliary ductal damage relative to the control animals, although statistical significance was not met in this pilot study: The mean percentage of positive pixels at Masson trichrome staining was 7.28% vs 5.57%, respectively (P = .20), the mean proliferation index with cytokeratin wide-spectrum was 2.55 vs 1.13 (P = .06), and the mean proliferation index with Ki67 was

  9. A Phase II randomised controlled trial assessing the feasibility, acceptability and potential effectiveness of Dignity Therapy for older people in care homes: Study protocol

    Directory of Open Access Journals (Sweden)

    Richardson Alison

    2009-03-01

    Full Text Available Abstract Background Although most older people living in nursing homes die there, there is a dearth of robust evaluations of interventions to improve their end-of-life care. Residents usually have multiple health problems making them heavily reliant on staff for their care, which can erode their sense of dignity. Dignity Therapy has been developed to help promote dignity and reduce distress. It comprises a recorded interview, which is transcribed, edited then returned to the patient, who can bequeath it to people of their choosing. Piloting has suggested that Dignity Therapy is beneficial to people dying of cancer and their families. The aims of this study are to assess the feasibility, acceptability and potential effectiveness of Dignity Therapy to reduce psychological and spiritual distress in older people reaching the end of life in care homes, and to pilot the methods for a Phase III RCT. Methods/design A randomised controlled open-label trial. Sixty-four residents of care homes for older people are randomly allocated to one of two groups: (i Intervention (Dignity Therapy offered in addition to any standard care, and (ii Control group (standard care. Recipients of the "generativity" documents are asked their views on taking part in the study and the therapy. Both quantitative and qualitative outcomes are assessed in face-to-face interviews at baseline and at approximately one and eight weeks after the intervention (equivalent in the control group. The primary outcome is residents' sense of dignity (potential effectiveness assessed by the Patient Dignity Inventory. Secondary outcomes for residents include depression, hopefulness and quality of life. In view of the relatively small sample size, quantitative analysis is mainly descriptive. The qualitative analysis uses the Framework method. Discussion Dignity Therapy is brief, can be done at the bedside and could help both patients and their families. This detailed exploratory research shows if

  10. A Feasibility study on Combining Internet-Based Cognitive Behaviour Therapy with Physical Exercise as Treatment for Panic Disorder--Treatment Protocol and Preliminary Results.

    Science.gov (United States)

    Hovland, Anders; Johansen, Henning; Sjøbø, Trond; Vøllestad, Jon; Nordhus, Inger Hilde; Pallesen, Ståle; Havik, Odd E; Martinsen, Egil W; Nordgreen, Tine

    2015-01-01

    Internet-based cognitive behaviour therapy (ICBT) is a recommended, cost-effective and efficacious treatment for panic disorder (PD). However, treatment effects in psychiatric settings indicate that a substantial proportion fail to achieve remission. Physical exercise improves symptoms in patients with PD, and acts through mechanisms that can augment the effect of ICBT. The feasibility of combining these two interventions has not previously been investigated, and this was the aim of this study. The intervention comprised guided ICBT combined with one weekly session of supervised and two weekly sessions of unsupervised physical exercise for a total of 12 weeks. Treatment rationale, procedures and protocols are presented together with preliminary results for four patients with PD who have currently finished treatment. Quantitative and qualitative results are reported on the feasibility of adhering to the treatments, treatment outcome as assessed by clinician rating and estimation of reliable and clinically significant change for outcome measures, and participants' satisfactions with the combined treatment. The preliminary results indicate that the combined treatment is feasible to complete, and that the combination is perceived by the participants as beneficial.

  11. Tribal Utility Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Engel, R. A.; Zoellick, J. J.

    2007-06-30

    The Schatz Energy Research Center (SERC) assisted the Yurok Tribe in investigating the feasibility of creating a permanent energy services program for the Tribe. The original purpose of the DOE grant that funded this project was to determine the feasibility of creating a full-blown Yurok Tribal electric utility to buy and sell electric power and own and maintain all electric power infrastructure on the Reservation. The original project consultant found this opportunity to be infeasible for the Tribe. When SERC took over as project consultant, we took a different approach. We explored opportunities for the Tribe to develop its own renewable energy resources for use on the Reservation and/or off-Reservation sales as a means of generating revenue for the Tribe. We also looked at ways the Tribe can provide energy services to its members and how to fund such efforts. We identified opportunities for the development of renewable energy resources and energy services on the Yurok Reservation that fall into five basic categories: • Demand-side management – This refers to efforts to reduce energy use through energy efficiency and conservation measures. • Off-grid, facility and household scale renewable energy systems – These systems can provide electricity to individual homes and Tribal facilities in areas of the Reservation that do not currently have access to the electric utility grid. • Village scale, micro-grid renewable energy systems - These are larger scale systems that can provide electricity to interconnected groups of homes and Tribal facilities in areas of the Reservation that do not have access to the conventional electric grid. This will require the development of miniature electric grids to serve these interconnected facilities. • Medium to large scale renewable energy development for sale to the grid – In areas where viable renewable energy resources exist and there is access to the conventional electric utility grid, these resources can be

  12. Schema therapy augmented exposure and response prevention in patients with obsessive-compulsive disorder: Feasibility and efficacy of a pilot study.

    Science.gov (United States)

    Thiel, Nicola; Jacob, Gitta A; Tuschen-Caffier, Brunna; Herbst, Nirmal; Külz, Anne Katrin; Hertenstein, Elisabeth; Nissen, Christoph; Voderholzer, Ulrich

    2016-09-01

    In spite of the availability of effective treatments for obsessive-compulsive disorder (OCD), many patients do not respond sufficiently or relapse. Treatments using other potentially effective methods such as experiential techniques need to be investigated. We developed a 12-week inpatient treatment augmenting exposure and response prevention (ERP) with schema therapy (ST) called STERP. The feasibility and effectiveness of STERP was tested.. In a pilot study, 10 inpatients with OCD who failed to respond to Cognitive Behavioral Therapy (CBT) with ERP received STERP. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) served as primary outcome. Secondary outcome measures were the Obsessive Compulsive Inventory-revised (OCI-R) and the Beck Depression Inventory (BDI-II). Treatment effects were assessed with t-tests for paired samples. Significant reductions of the Y-BOCS, OCI-R and the BDI-II were found, with very large effect sizes (Cohen's d = 1.48-2.25). Results remained stable at 6 months follow-up. Five prior non-responders responded according to the 35% Y-BOCS symptom reduction criterion.. Lack of control group, small sample size and lack of repeated outcome measures during baseline. STERP may be a feasible and potentially effective treatment for prior non-responders among OCD patients and thus worth further investigation in randomized controlled trials.. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Feasibility of Group Schema Therapy for Outpatients with Severe Borderline Personality Disorder in Germany: A Pilot Study with Three Year Follow-Up.

    Science.gov (United States)

    Fassbinder, Eva; Schuetze, Maren; Kranich, Annika; Sipos, Valerija; Hohagen, Fritz; Shaw, Ida; Farrell, Joan; Arntz, Arnoud; Schweiger, Ulrich

    2016-01-01

    Borderline Personality Disorder (BPD) is a severe, challenging to treat mental disorder. Schema therapy (ST) as an individual therapy has been proven to be an effective psychological treatment for BPD. A group format of ST (GST) has been developed and evaluated in a randomized controlled trial in the United States and piloted in The Netherlands. These results suggest that GST speeds up and amplifies treatment effects of ST and might reduce delivery costs. However, feasibility in the German health care system and with BPD patients with high BPD severity and comorbidity, and frequent hospitalization, has not been tested to date. We investigated GST in 10 severely impaired, highly comorbid female patients with BPD, that needed frequent hospital admission. Patients received an outpatient ST-treatment program with weekly group and individual sessions for 1 year. Outcome measures including BPD severity, general psychopathology, psychosocial functioning, quality of life, happiness, schemas, and modes, and days of hospitalization were assessed at the start of treatment and 6, 12, and 36 months later with semi-structured interviews and self-report measures. We observed significant decreases in severity of BPD symptoms, general symptom severity, dysfunctional BPD-specific modes and schemas, and days of hospitalization. Functional modes, quality of live and happiness improved. The results of this feasibility study are promising and encourage further implementation of ST outpatient treatment programs even for patients with severe BPD and high hospitalization risk. However, small sample size and the missing of a control group do not allow the generalizability of these findings.

  14. Feasibility of cognitive remediation therapy for adults with autism spectrum disorders: a single-group pilot study

    Directory of Open Access Journals (Sweden)

    Okuda T

    2017-08-01

    Full Text Available Tomoko Okuda,1,2 Kenichi Asano,1,3 Noriko Numata,4 Yoshiyuki Hirano,1,3 Tetsuya Yamamoto,5 Mari Tanaka,4 Daisuke Matsuzawa,4 Eiji Shimizu,1,3,4 Masaomi Iyo,5,6 Michiko Nakazato1,3,6 1Division of Cognitive Behavioral Science, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Chiba-shi, Chiba, 2Department of Psychiatry, Chibaken Saiseikai Narashino Hospital, Narashino, 3Research Center for Child Mental Development, Chiba University, 4Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, 5Center for Forensic Mental Health, Chiba University, 6Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan Background: Set-shifting (SS difficulties and weak central coherence (CC are commonly associated with autism spectrum disorders (ASD. Cognitive remediation therapy (CRT aims to improve such cognitive processing; however, there are no reports on CRT for patients with ASD. This pilot study aimed to provide preliminary evidence to support the use of CRT for individuals with ASD and provide data to inform future studies.Participants and methods: Nineteen individuals with ASD were recruited and administered a series of neuropsychological and questionnaire measures to examine cognitive function and clinical outcomes such as anxiety and depression. Participants received CRT, and cognitive function and clinical variables were re-evaluated at postintervention and after 3 months.Results: The participants demonstrated significant improvement in CC and anxiety at postintervention, which was maintained at 3-month follow-up. Although SS scores had improved with a large effect size, this was not statistically significant.Conclusion: CRT improved CC and anxiety scores for individuals with ASD, suggesting that CRT is an effective treatment for individuals with ASD. Keywords: autism

  15. Flathead Renewable Energy Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Belvin Pete: Ed McCarthy; Krista Gordon; Chris Bergen; Rhett Good

    2006-10-03

    The study shall assess the feasibility of a commercial wind facility on lands selected and owned by the Salish and Kootenai Tribes and shall examine the potential for the development of solar and biomass resources located on Tribal Lands.

  16. Feasibility of cognitive remediation therapy for adults with autism spectrum disorders: a single-group pilot study

    Science.gov (United States)

    Okuda, Tomoko; Asano, Kenichi; Numata, Noriko; Hirano, Yoshiyuki; Yamamoto, Tetsuya; Tanaka, Mari; Matsuzawa, Daisuke; Shimizu, Eiji; Iyo, Masaomi; Nakazato, Michiko

    2017-01-01

    Background Set-shifting (SS) difficulties and weak central coherence (CC) are commonly associated with autism spectrum disorders (ASD). Cognitive remediation therapy (CRT) aims to improve such cognitive processing; however, there are no reports on CRT for patients with ASD. This pilot study aimed to provide preliminary evidence to support the use of CRT for individuals with ASD and provide data to inform future studies. Participants and methods Nineteen individuals with ASD were recruited and administered a series of neuropsychological and questionnaire measures to examine cognitive function and clinical outcomes such as anxiety and depression. Participants received CRT, and cognitive function and clinical variables were re-evaluated at postintervention and after 3 months. Results The participants demonstrated significant improvement in CC and anxiety at postintervention, which was maintained at 3-month follow-up. Although SS scores had improved with a large effect size, this was not statistically significant. Conclusion CRT improved CC and anxiety scores for individuals with ASD, suggesting that CRT is an effective treatment for individuals with ASD. PMID:28860776

  17. A Simulation Study on the Feasibility of Radio Enhancement Therapy with Calcium Tungstate and Hafnium Oxide Nanoparticles

    CERN Document Server

    Sherck, Nicholas J

    2016-01-01

    Herein is a simulation study on the radio enhancement potential of calcium tungstate (CaWO4) and hafnium oxide (HfO2) nanoparticles (NPs) relative to gold (Au) NPs. The work utilizes the extensively studied Au NP as the "gold standard" to which the novel materials can be compared. All three materials were investigated in-silico with the software Penetration and Energy Loss of Positrons and Electrons (PENELOPE) developed by Francesc Salvat and distributed in the United States by the Radiation Safety Information Computational Center (RSICC) at Oak Ridge National Laboratory. The aims are: (1) Do CaWO4 and HfO2 NPs function like Au?, and (2) if not, how else might they function to enhance radio therapy? Our investigations have found that HfO2 likely functions as Au, but not as effectively. CaWO4 likely does not function as Au, and we propose that CaWO4 may exhibit cancer killing traits through its intrinsic UV luminescence property.

  18. Feasibility and effectiveness of adding object-related bilateral symmetrical training to mirror therapy in chronic stroke: A randomized controlled pilot study.

    Science.gov (United States)

    Rodrigues, Letícia Cardoso; Farias, Nayara Correa; Gomes, Raquel Pinheiro; Michaelsen, Stella Maris

    2016-01-01

    To evaluate the feasibility and effectiveness of adding object-related bilateral symmetrical training to mirror therapy (MT) to improve upper limb (UL) activity in chronic stroke patients. Sixteen patients with moderate UL impairment were randomly allocated to either the experimental (EG) or control (CG) group. Both groups performed 1 hour sessions, 3 days/week for 4 weeks, involving object-related bilateral symmetrical training. EG performed the tasks observing their nonparetic UL reflected in the mirror, while CG observed the paretic UL directly. The primary outcome measure was unilateral and bilateral UL activity according to the Test d'Évaluation des Membres Supérieurs de Personnes Âgées (TEMPA). All measurements were taken at baseline, post-training, and follow-up (2 weeks). TEMPA total score showed the main effect of time. Significant improvement was found for bilateral but not unilateral tasks. Both groups showed gains after training, with no differences between them. This study showed the feasibility of adding object-related bilateral training to MT. Both types of training improved UL bilateral activity; however, a larger sample is required for a definitive study. Other studies need to be carried out to evaluate the effectiveness of combining more distal-oriented movements and object-related unilateral training to improve these effects in chronic stroke patients.

  19. Physical activity and body composition, body physique, and quality of life in premenopausal breast cancer patients during endocrine therapy--a feasibility study.

    Science.gov (United States)

    Hojan, Katarzyna; Molińska-Glura, Marta; Milecki, Piotr

    2013-02-01

    Endocrine therapy (ET) is a common method of treatment in breast cancer patients; however, its negative impact on body composition, body physique (physical body shape/measurements), and quality of life (QoL) remains controversial. Previous studies have shown physical exercise can have a positive effect on QoL in breast cancer patients, especially premenopausal subjects. In this feasibility study, we sought to assess the impact that physical exercise had on body composition and QoL in premenopausal breast cancer patients undergoing ET, and to determine the appropriateness of further testing of this intervention in this patient group. This study involved 41 premenopausal female breast cancer patients before and after six, 12, and 18 months of ET. Aerobic training began in the 6th month and resistance training was added in the 12th month. Body composition was evaluated using dual-energy x-ray absorptiometry (DXA) scans, body physique was evaluated using anthropometric measurement techniques, and QoL was evaluated using questionnaires from the European Organization for Research and Treatment of Cancer. The initial period of ET with no exercise resulted in a reduction in fat-free body mass (FFBM), an increase in fat body mass (FBM), and a decline in QoL scores. Adding aerobic training resulted in a reduction of FBM and percentage of android fat, and improved QoL scores. The introduction of resistance training further reduced percentage of android and gynoid fat, increased FFBM, and further improved QoL scores. ET negatively impacts body composition, body physique, and QoL of premenopausal breast cancer patients. This feasibility study shows that physical activity may improve QoL and reduce adverse effects of ET on body composition and body physique, indicating appropriateness for further investigation on the use of exercise programs in premenopausal breast cancer patients to improve the outcomes of therapy.

  20. A mixed methods feasibility study to evaluate the use of a low-intensity, nurse-delivered cognitive behavioural therapy for the treatment of irritable bowel syndrome

    Science.gov (United States)

    Dainty, Andrew David; Fox, Mark; Lewis, Nina; Hunt, Melissa; Holtham, Elizabeth; Timmons, Stephen; Kinsella, Philip; Wragg, Andrew; Callaghan, Patrick

    2014-01-01

    Introduction Irritable bowel syndrome (IBS) is characterised by symptoms such as abdominal pain, constipation, diarrhoea and bloating. These symptoms impact on health-related quality of life, result in excess service utilisation and are a significant burden to healthcare systems. Certain mechanisms which underpin IBS can be explained by a biopsychosocial model which is amenable to psychological treatment using techniques such as cognitive behavioural therapy (CBT). While current evidence supports CBT interventions for this group of patients, access to these treatments within the UK healthcare system remains problematic. Methods and analysis A mixed methods feasibility randomised controlled trial will be used to assess the feasibility of a low-intensity, nurse-delivered guided self-help intervention within secondary care gastrointestinal clinics. A total of 60 participants will be allocated across four treatment conditions consisting of: high-intensity CBT delivered by a fully qualified cognitive behavioural therapist, low-intensity guided self-help delivered by a registered nurse, self-help only without therapist support and a treatment as usual control condition. Participants from each of the intervention arms of the study will be interviewed in order to identify potential barriers and facilitators to the implementation of CBT interventions within clinical practice settings. Quantitative data will be analysed using descriptive statistics only. Qualitative data will be analysed using a group thematic analysis. Ethics and dissemination This study will provide essential information regarding the feasibility of nurse-delivered CBT interventions within secondary care gastrointestinal clinics. The data gathered during this study would also provide useful information when planning a substantive trial and will assist funding bodies when considering investment in substantive trial funding. A favourable opinion for this research was granted by the Nottingham 2 Research

  1. Digital signature feasibility study

    Science.gov (United States)

    2008-06-01

    The purpose of this study was to assess the advantages and disadvantages of using digital signatures to assist the Arizona Department of Transportation in conducting business. The Department is evaluating the potential of performing more electronic t...

  2. A feasibility study of brief group-based acceptance and commitment therapy for chronic pain in general practice: recruitment, attendance, and patient views.

    Science.gov (United States)

    McCracken, Lance M; Sato, Ayana; Wainwright, David; House, William; Taylor, Gordon J

    2014-07-01

    Acceptance and commitment therapy (ACT), a form of cognitive-behavioral therapy, may help meet a need for accessible and cost-effective treatments for chronic pain. ACT has a growing evidence base, but has not yet been tested within general practice settings. The purpose of the present study was to examine the feasibility of conducting a full-scale randomized controlled trial of ACT in general practice. A total of 481 potential participants with chronic pain identified from general practice in southwest England were invited into a treatment trial. Subsequently, 102 (21.2%) of those invited were screened, and 73 (71.6%) of those screened were allocated to ACT plus usual care or usual care alone. The ACT treatment included four, four-hour group-based sessions over two weeks. Twenty-six (70.3%) of the patients allocated to ACT attended three or four sessions. Those who received ACT rated it as credible in a short survey, with Mdn rating 7.0 on a 0-10 scale, across five credibility items. During a post-treatment interview considering 12 aspects of the study from invitation to treatment termination, a median of 79.2% of participants rated the aspects 'acceptable.' Qualitative data from the interviews showed a mixed picture of patient experiences, revealing possible tensions between patients' wishes to avoid discomfort and confusion, and treatment methods that explicitly ask patients to, in essence, 'live with' some discomfort and confusion. These data suggest that further study of ACT, as a treatment for chronic pain, is feasible in general practice and it may be possible to further optimize the treatment experience.

  3. HUMANICS 1. A feasibility study to create a home internet based telehealth product to supplement acquired brain injury therapy

    DEFF Research Database (Denmark)

    Brooks, Tony

    2005-01-01

    The goal of the project was to produce a unique, cost effective, and user-friendly computer based telehealth system product which had longevity and the ability to be integrated modularly into a future internet-based health care communication provision. This was conceptualised as an aid to home......-based self-training through motivated creativity via manipulation of a digital multimedia game form. The system was to be a supplementary tool for therapists. The targeted group was adults with acquired brain injury. This paper details the first phase of the product feasibility....

  4. Wind Farm Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Richard Curry; Erik Foley; DOE Project Officer - Keith Bennett

    2007-07-11

    Saint Francis University has assessed the Swallow Farm property located in Shade Township, Somerset County, Pennsylvania as a potential wind power development site. Saint Francis worked with McLean Energy Partners to have a 50-meter meteorological tower installed on the property in April 2004 and continues to conduct a meteorological assessment of the site. Results suggest a mean average wind speed at 80 meters of 17 mph with a net capacity factor of 31 - 33%. Approximate electricity generation capacity of the project is 10 megawatts. Also, the University used matching funds provided by the federal government to contract with ABR, Inc. to conduct radar studies of nocturnal migration of birds and bats during the migrations seasons in the Spring and Fall of 2005 with a mean nocturnal flight altitude of 402 meters with less than 5% of targets at altitudes of less than 125 meters. The mean nocturnal passage rate was 166 targets/km/h in the fall and 145 targets/km/h in the spring. Lastly, University faculty and students conducted a nesting bird study May - July 2006. Seventy-three (73) species of birds were observed with 65 determined to be breeding or potentially breeding species; this figure represents approximately 30% of the 214 breeding bird species in Pennsylvania. No officially protected avian species were determined to be nesting at Swallow Farm.

  5. Internet based self-help therapy versus waitlist control group for persons with anxiety disorders: A randomised feasibility study

    DEFF Research Database (Denmark)

    Fenger, Morten Munthe; Lindschou, Jane; Gluud, Christian

    ) FearFighter or B) waitlist control group. Participants are persons with a diagnosis of social phobia, agora phobia, phobia or panic disorder. The intervention with FearFighter is a nine step cognitive behavioural self-help therapy program delivered over the internet over nine weeks. Participants...

  6. The effect of using music therapy with relaxation imagery in the management of patients undergoing bone marrow transplantation: a pilot feasibility study.

    Science.gov (United States)

    Sahler, Olle Jane Z; Hunter, Bryan C; Liesveld, Jane L

    2003-01-01

    Bone marrow/stem cell transplantation is becoming an increasingly common treatment for a variety of hematologic disorders. The treatment process is not benign. Both physiologic and psychological regimen-related side effects are common, painful, and even life threatening. Music therapy is the prescribed use of music to aid in the prevention or amelioration of physical, psychological, or cognitive problems. Relaxation imagery, as used in this study, consisted of simple visualization and direct imagery-based suggestions. The mechanism of action of the intervention is hypothesized to be reduction of the stress response through neuroendocrine pathways. To determine the feasibility of providing a combined music therapy and relaxation imagery intervention to patients on a bone marrow transplant (BMT) unit and to examine the effects on the frequency and intensity of pain and nausea, the two most common side effects associated with transplantation. Case controlled study. University hospital-based bone marrow transplant unit serving patients of all ages. Transplant recipients aged 4 years or older. 45-minute music-assisted relaxation and relaxation imagery sessions provided twice a week by a trained music therapist from date of enrollment into the study to discharge. Pre/post music/relaxation imagery intervention measures of pain and nausea using a visual analog scale; determination of time-to-engraftment.

  7. Therapist-guided, Internet-based cognitive–behavioural therapy for body dysmorphic disorder (BDD-NET): a feasibility study

    Science.gov (United States)

    Enander, Jesper; Ivanov, Volen Z; Andersson, Erik; Mataix-Cols, David; Ljótsson, Brjánn; Rück, Christian

    2014-01-01

    Objectives Cognitive–behavioural therapy (CBT) is an effective treatment for body dysmorphic disorder (BDD). However, most sufferers do not have access to this treatment. One way to increase access to CBT is to administer treatment remotely via the Internet. This study piloted a novel therapist-supported, Internet-based CBT program for BDD (BDD-NET). Design Uncontrolled clinical trial. Participants Patients (N=23) were recruited through self-referral and assessed face to face at a clinic specialising in obsessive–compulsive and related disorders. Suitable patients were offered secure access to BDD-NET. Intervention BDD-NET is a 12-week treatment program based on current psychological models of BDD that includes psychoeducation, functional analysis, cognitive restructuring, exposure and response prevention, and relapse prevention modules. A dedicated therapist provides active guidance and feedback throughout the entire process. Main outcome measure The clinician-administered Yale-Brown Obsessive Compulsive Scale for BDD (BDD-YBOCS). Symptom severity was assessed pretreatment, post-treatment and at the 3-month follow-up. Results BDD-NET was deemed highly acceptable by patients and led to significant improvements on the BDD-YBOCS (p=<0.001) with a large within-group effect size (Cohen's d=2.01, 95% CI 1.05 to 2.97). At post-treatment, 82% of the patients were classified as responders (defined as≥30% improvement on the BDD-YBOCS). These gains were maintained at the 3-month follow-up. Secondary outcome measures of depression, global functioning and quality of life also showed significant improvements with moderate to large effect sizes. On average, therapists spent 10 min per patient per week providing support. Conclusions The results suggest that BDD-NET has the potential to greatly increase access to CBT, at least for low-risk individuals with moderately severe BDD symptoms and reasonably good insight. A randomised controlled trial of BDD-NET is warranted

  8. Feasibility of group schema therapy for outpatients with severe borderline personality disorder in Germany: A pilot study with three year follow-up

    Directory of Open Access Journals (Sweden)

    Eva Fassbinder

    2016-11-01

    Full Text Available Borderline Personality Disorder (BPD is a severe, challenging to treat mental disorder. Schema therapy (ST as an individual therapy has been proven to be an effective psychological treatment for BPD. A group format of ST (GST has been developed and evaluated in a randomized controlled trial in the United States and piloted in The Netherlands. These results suggest that GST speeds up and amplifies treatment effects of ST and might reduce delivery costs. However, feasibility in the German health care system and with BPD patients with high BPD severity and comorbidity, and frequent hospitalization, has not been tested to date. We investigated GST in ten severely impaired, highly comorbid female patients with BPD, that needed frequent hospital admission. Patients received an outpatient ST-treatment program with weekly group and individual sessions for one year. Outcome measures including BPD severity, general psychopathology, psychosocial functioning, quality of life, happiness, schemas and modes, and days of hospitalization were assessed at the start of treatment and six, twelve and 36 months later with semi-structured interviews and self-report measures. We observed significant decreases in severity of BPD symptoms, general symptom severity, dysfunctional BPD-specific modes and schemas, and days of hospitalization. Functional modes, quality of live and happiness improved. The results of this feasibility study are promising and encourage further implementation of ST outpatient treatment programs even for patients with severe BPD and high hospitalization risk. However, small sample size and the missing of a control group do not allow the generalizability of these findings.

  9. Feasibility of Group Schema Therapy for Outpatients with Severe Borderline Personality Disorder in Germany: A Pilot Study with Three Year Follow-Up

    Science.gov (United States)

    Fassbinder, Eva; Schuetze, Maren; Kranich, Annika; Sipos, Valerija; Hohagen, Fritz; Shaw, Ida; Farrell, Joan; Arntz, Arnoud; Schweiger, Ulrich

    2016-01-01

    Borderline Personality Disorder (BPD) is a severe, challenging to treat mental disorder. Schema therapy (ST) as an individual therapy has been proven to be an effective psychological treatment for BPD. A group format of ST (GST) has been developed and evaluated in a randomized controlled trial in the United States and piloted in The Netherlands. These results suggest that GST speeds up and amplifies treatment effects of ST and might reduce delivery costs. However, feasibility in the German health care system and with BPD patients with high BPD severity and comorbidity, and frequent hospitalization, has not been tested to date. We investigated GST in 10 severely impaired, highly comorbid female patients with BPD, that needed frequent hospital admission. Patients received an outpatient ST-treatment program with weekly group and individual sessions for 1 year. Outcome measures including BPD severity, general psychopathology, psychosocial functioning, quality of life, happiness, schemas, and modes, and days of hospitalization were assessed at the start of treatment and 6, 12, and 36 months later with semi-structured interviews and self-report measures. We observed significant decreases in severity of BPD symptoms, general symptom severity, dysfunctional BPD-specific modes and schemas, and days of hospitalization. Functional modes, quality of live and happiness improved. The results of this feasibility study are promising and encourage further implementation of ST outpatient treatment programs even for patients with severe BPD and high hospitalization risk. However, small sample size and the missing of a control group do not allow the generalizability of these findings. PMID:27933020

  10. A 12-week supervised exercise therapy program for young adults with a meniscal tear: Program development and feasibility study

    DEFF Research Database (Denmark)

    Skou, Søren T.; Thorlund, Jonas B.

    2018-01-01

    interview. Feedback from patients was included to finalize the exercise therapy program. Median improvements (Range) in KOOS subscales were 15 (0–33) for Pain, 11 (−11 to 50) for Symptoms, 16 (3–37) for Function in daily living, 23 (10–45) for Function in sport and recreation, and 9 (−6 to 31) for Quality...... on clinical expertise and available evidence. Six patients (age range 22–39 years) considered eligible for meniscal surgery by an orthopedic surgeon underwent the program. Patients completed the Knee Injury and Osteoarthritis Outcome Score (KOOS) and evaluated the program during a semi-structured qualitative...... of life. The patients found the program relevant and effective with only a few short-lasting adverse events and important clinical improvements after four to ten weeks. Physical therapist supervision was considered important. No patients wanted surgery up to 6 month after the exercise therapy program...

  11. TOOTH (The Open study Of dental pulp stem cell Therapy in Humans): Study protocol for evaluating safety and feasibility of autologous human adult dental pulp stem cell therapy in patients with chronic disability after stroke.

    Science.gov (United States)

    Nagpal, Anjali; Kremer, Karlea L; Hamilton-Bruce, Monica A; Kaidonis, Xenia; Milton, Austin G; Levi, Christopher; Shi, Songtao; Carey, Leeanne; Hillier, Susan; Rose, Miranda; Zacest, Andrew; Takhar, Parabjit; Koblar, Simon A

    2016-07-01

    Stroke represents a significant global disease burden. As of 2015, there is no chemical or biological therapy proven to actively enhance neurological recovery during the chronic phase post-stroke. Globally, cell-based therapy in stroke is at the stage of clinical translation and may improve neurological function through various mechanisms such as neural replacement, neuroprotection, angiogenesis, immuno-modulation, and neuroplasticity. Preclinical evidence in a rodent model of middle cerebral artery ischemic stroke as reported in four independent studies indicates improvement in neurobehavioral function with adult human dental pulp stem cell therapy. Human adult dental pulp stem cells present an exciting potential therapeutic option for improving post-stroke disability. TOOTH (The Open study Of dental pulp stem cell Therapy in Humans) will investigate the use of autologous stem cell therapy for stroke survivors with chronic disability, with the following objectives: (a) determine the maximum tolerable dose of autologous dental pulp stem cell therapy; (b) define that dental pulp stem cell therapy at the maximum tolerable dose is safe and feasible in chronic stroke; and (c) estimate the parameters of efficacy required to design a future Phase 2/3 clinical trial. TOOTH is a Phase 1, open-label, single-blinded clinical trial with a pragmatic design that comprises three stages: Stage 1 will involve the selection of 27 participants with middle cerebral artery ischemic stroke and the commencement of autologous dental pulp stem cell isolation, growth, and testing in sequential cohorts (n = 3). Stage 2 will involve the transplantation of dental pulp stem cell in each cohort of participants with an ascending dose and subsequent observation for a 6-month period for any dental pulp stem cell-related adverse events. Stage 3 will investigate the neurosurgical intervention of the maximum tolerable dose of autologous dental pulp stem cell followed by 9 weeks of intensive task

  12. Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy.

    Directory of Open Access Journals (Sweden)

    Jia-Cheng Lee

    Full Text Available Diffuse intrinsic pontine glioma is a very frustrating disease. Since the tumor infiltrates the brain stem, surgical removal is often impossible. For conventional radiotherapy, the dose constraint of the brain stem impedes attempts at further dose escalation. Boron neutron capture therapy (BNCT, a targeted radiotherapy, carries the potential to selectively irradiate tumors with an adequate dose while sparing adjacent normal tissue. In this study, 12 consecutive patients treated with conventional radiotherapy in our institute were reviewed to evaluate the feasibility of BNCT. NCTPlan Ver. 1.1.44 was used for dose calculations. Compared with two and three fields, the average maximal dose to the normal brain may be lowered to 7.35 ± 0.72 Gy-Eq by four-field irradiation. The mean ratio of minimal dose to clinical target volume and maximal dose to normal tissue was 2.41 ± 0.26 by four-field irradiation. A therapeutic benefit may be expected with multi-field boron neutron capture therapy to treat diffuse intrinsic pontine glioma without craniotomy, while the maximal dose to the normal brain would be minimized by using the four-field setting.

  13. Stereotactic body radiation therapy (SBRT) for adrenal metastases : a feasibility study of advanced techniques with modulated photons and protons.

    Science.gov (United States)

    Scorsetti, Marta; Mancosu, Pietro; Navarria, Piera; Tozzi, Angelo; Castiglioni, Simona; Clerici, Elena; Reggiori, Giacomo; Lobefalo, Francesca; Fogliata, Antonella; Cozzi, Luca

    2011-04-01

    To compare advanced treatment techniques with photons and protons as a stereotactic body radiation therapy (SBRT) for adrenal glands metastases. Planning computer tomographic (CT) scans of 10 patients were selected. A total dose of 45 Gy in 7.5 Gy fractions was prescribed. Organs at risk (OAR) were liver and kidneys. Dose-volume metrics were defined to quantify quality of plans assessing target coverage and sparing of organs at risk. Plans for RapidArc, intensity-modulated radiotherapy (IMRT), dynamic conformal arcs, 3D conformal static fields, and intensity modulated protons were compared. The main planning objective for the clinical target volume (CTV) was to cover 100% of the volume with 95% (V(95%) = 100%) and to keep the maximum dose below 107% of the prescribed dose (V(107%) = 0%). Planning objective for planning target volume (PTV) was V(95%) > 80%. For kidneys, the general planning objective was V(15Gy) protons) to 1.6 Gy (conformal static fields) on CTV. Maximal organ at risk sparing was achieved by protons. RapidArc presented the second lowest dose bath (V(10Gy) and integral dose) after protons and the best conformality together with IMRT. Stereotactic body radiation therapy (SBRT) to adrenal glands metastases is achievable with several advanced techniques with either photons or protons. The intensity modulated approaches using either static fields, dynamic arcs or protons are superior to the other conformal solutions. For their simplicity, IMRT or RapidArc should be considered as the first option radiation treatment for those patients not eligible for proton treatment.

  14. Feasibility of Central Meditation and Imagery Therapy for Dementia Caregivers

    Science.gov (United States)

    Jain, Felipe A.; Nazarian, Nora; Lavretsky, Helen

    2014-01-01

    Objectives Family dementia caregivers are at high risk of depression and burnout. We aimed to assess the feasibility of Central Meditation and Imagery Therapy for Caregivers (CMIT-C), a novel 8-week group meditation and guided imagery group therapy program, for dementia caregivers reporting stress due to caregiving responsibilities. Methods 12 family dementia caregivers enrolled in CMIT-C. Primary outcomes included depression and anxiety, and secondary included insomnia, quality of life, and mindfulness. Changes over the study and three month follow-up were analyzed with non-parametric related samples tests. Correlations of feeling state changes from meditation diaries at 1 week were made with symptom changes post meditation training. Results 10 participants completed the study. Completers came to an average of 7 ± 1 sessions out of a possible 8, and turned in home practice logs 90 ± 10% of the time. Anxiety, depression and insomnia symptoms decreased, and mindfulness ratings improved with large effects (all p meditation practice was associated with subsequent home meditation practice, anxiety change at eight weeks, and endpoint satisfaction with CMIT-C. Conclusions CMIT-C is a feasible intervention for dementia caregivers. Results suggest that this therapeutic technique can reduce symptoms of anxiety, depression, and insomnia, and increase levels of mindfulness. Early response to meditation practice predicted those with the greatest short-term benefits, and this may inform future studies of meditation. Larger, controlled efficacy studies of CMIT-C for dementia caregivers are warranted. PMID:24477920

  15. Assessment of feasibility and efficacy of Class IV laser therapy for postoperative pain relief in off-pump coronary artery bypass surgery patients: A pilot study

    Directory of Open Access Journals (Sweden)

    Anil Karlekar

    2015-01-01

    Full Text Available Background: Laser therapy, for its established analgesic properties with minimal side effects, has been used for the treatment of chronic pain. However, it has not been used for the treatment of acute postoperative pain. This pilot study was designed to assess the feasibility and efficacy of Class IV laser on postoperative pain relief following off-pump coronary artery bypass graft (OPCABG surgery, as a component of multimodal analgesia (MMA technique. Methods: This open observational prospective study comprised of 100 adult patients (84 male, 16 female who underwent OPCABG through sternotomy. For postoperative analgesia, they were subjected to laser therapy subjected to laser therapy in addition to the standard institutional pain management protocol comprising of IV infusion/bolus of tramadol and paracetamol and fentanyl bolus as rescue analgesic. Pain intensity was measured by Verbal Rating Scale (VRS. The laser therapy was scheduled as once a day regime for three consecutive postoperative days (PODs starting on POD 1, 30 min following tracheal extubation. The subsequent laser applications were also scheduled at the same time of the day as on day 1 if VRS was ≥5. 10 W Class IV laser was applied over 150 cm 2 sternal wound area for 150 s. VRS was used to assess pain severity and was recorded for statistical analysis using Friedman Test. Results: The mean (standard deviation [SD] VRS of all the 100 patients just before application of the first dose of laser was 7.31 (0.94 while on MMT; the same fell to 4.0 (1.279 and 3.40 (2.697 at 1 h and 24 h respectively following first dose of laser. The change of VRS over first 24 h among all the 100 patients was statistically significant (P = 0.000. Laser was re-applied in 40 patients whose VRS was ≥5 (mean [SD] - 6.38 [0.868] at 24 th h. After receiving the 2 nd dose of laser the VRS scores fell significantly (P = 0.000 and became 0 at 54 th h. No patients required 3 rd dose of the laser. No patient

  16. Effects of music therapy and music-assisted relaxation and imagery on health-related outcomes in diabetes education: a feasibility study.

    Science.gov (United States)

    Mandel, Susan E; Davis, Beth A; Secic, Michelle

    2013-01-01

    The purpose of the feasibility study was to compare the effects of music-assisted relaxation and imagery, administered via compact disc recording (MARI CD) without therapeutic intervention, to the effects of music therapy (MT), facilitated by a board-certified music therapist, on selected health outcomes of patients enrolled in diabetes self-management education/training (DSME/T). A 3-group, parallel, randomized controlled trial with 199 patients, aged 30 to 85 years with type 1, type 2, or prediabetes was employed. Patients were enrolled in a study from 2 hospital sites and randomly assigned to: DSME/T alone, DSME/T plus MARI CD, or DSME/T plus MT. The MARI CD included researcher-selected music and spoken suggestions, while MT included therapeutic experiences with personally preferred relaxing and energizing music. Outcome measures included blood pressure, glycosylated hemoglobin (A1C), body mass index (BMI), trait anxiety, state anxiety, and stress. There were no statistically significant differences among the 3 conditions in blood pressure, A1C, BMI, trait anxiety, or stress. Significant changes over time were evident in the MT condition from pre- to post-each session in systolic blood pressure, state anxiety, and stress. Blood pressure changes were compared pre- to postprogram for those patients with a comorbidity of hypertension between DSME/T alone and a combined music intervention group (MT and MARI CD). It was found that the music intervention group had a significantly larger decrease in systolic blood pressure. Themes derived from patient narratives further informed the data. The study results support the relationship between DSME/T and improvement on all measured outcomes except blood pressure. Results suggest the feasibility of integrating MARI and MT with DSME/T to potentially lower systolic blood pressure of patients with diabetes and a comorbidity of hypertension. Collaboration between diabetes educators and board-certified music therapists is

  17. Acceptance and commitment therapy in youth with neurofibromatosis type 1 (NF1) and chronic pain and their parents: A pilot study of feasibility and preliminary efficacy.

    Science.gov (United States)

    Martin, Staci; Wolters, Pamela L; Toledo-Tamula, Mary Anne; Schmitt, Shawn Nelson; Baldwin, Andrea; Starosta, Amy; Gillespie, Andrea; Widemann, Brigitte

    2016-06-01

    Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder affecting about 1 in 3,500 individuals. Chronic pain is commonly reported among individuals with NF1 and plexiform neurofibroma tumors (PNs). Acceptance and Commitment Therapy (ACT), an empirically supported method for addressing chronic pain, helps individuals re-focus on valued relationships and activities. This pilot study investigated the feasibility and preliminary efficacy of a brief ACT workshop in the NF1 population. Eligible participants included adolescents and young adults (AYA; 12-21 years) with NF1 and chronic pain that interfered with daily functioning and their parents. Patients and parents completed baseline measures of pain interference, pain intensity, functional disability, pain acceptance, depression, and anxiety. Then, AYA and parents participated separately in a 2-day small-group ACT workshop. A telephone booster session occurred 1 month post-intervention. Three-month post-treatment measures were completed by mail. Ten adolescents (4 males; M age = 16.9 years) and seven parents provided baseline and 3-month data. Mean satisfaction with the study was moderate to high (3.9 for patients and 4.6 for parents on a 1-5 scales). Patients and parents reported significant declines in patients' pain interference at 3 months post-treatment. Patient-reported pain intensity significantly declined from baseline to 3 months. Parents reported marginally greater acceptance of their child's pain. No changes emerged in functional ability or mood. Preliminary findings suggest that a brief ACT group intervention is feasible and may help AYA with NF1 and PNs cope with their chronic pain, although larger randomized studies are needed to confirm treatment efficacy. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. [Impact of music therapy on anxiety and depression for patients with Alzheimer's disease and on the burden felt by the main caregiver (feasibility study)].

    Science.gov (United States)

    Guetin, S; Portet, F; Picot, M-C; Defez, C; Pose, C; Blayac, J-P; Touchon, J

    2009-02-01

    The impact of music therapy on dementia care for patients with Alzheimer's disease (AD) is well-recognized. Music alters the different components of the disease through sensory, cognitive, emotional, behavioral and social impacts. The academic aspect of music therapy in this area was based on the fact that music can alter the various components of the overall evolution of this disease. We found around 10 case studies presenting various results from receptive music therapy sessions on patients with Alzheimer's disease. The results of these studies point out the interest of music therapy in the multidisciplinary care of Alzheimer's disease and its related syndromes. It has been deemed useful for significantly reducing the medication given to AD patients. A music therapy protocol, specifically tailored to the patient's needs has been shown to significantly reduce anxiety, depression and aggressiveness in patients suffering from Alzheimer's disease. This technique has also demonstrated its impact on helping AD patients recall their previous life experience. To demonstrate the feasibility and to evaluate the impact of music therapy on anxiety and depression at the early to moderate stage of Alzheimer's disease and on the main caregiver burden. Five outpatients suffering from early stage of Alzheimer's disease (MMS: 18-26) were prospectively included. They were living in Montpellier with a reliable caregiver. A weekly receptive music therapy session was delivered to patients over a 10-week period, according to the U method standardized protocol. This technique was based on the recommendations made by Gardner and Good relating to the importance given to an individualized choice of music. Instrumental tracks were selected from various music styles (classic, jazz, world music...) and were tailored to the patient's requirements. This individual session was always followed by an interview with the music therapist in order to allow the patient to express the emotions felt

  19. A feasibility study of a hybrid breast-immobilization system for early breast cancer in proton beam therapy.

    Science.gov (United States)

    Arimura, Takeshi; Ogino, Takashi; Yoshiura, Takashi; Matsuyama, Mitsugi; Kondo, Naoaki; Miyazaki, Hideki; Sakuragi, Akari; Ohara, Takayuki; Ogo, Etsuyo; Hishikawa, Yoshio

    2017-04-01

    We aimed to develop a new breast-immobilizing system for proton beam therapy (PBT) of early breast cancer (EBC) that would provide the optimum breast shape during the treatment as well as increased fixation reliability by reducing the influence of respiratory movement. The breast-immobilizing system (HyBIS; hybrid breast-immobilizing system) consists of a whole body immobilization system (WBIS), position-converting device (to change patient position), photo-scanning system, breast cup (made using a three-dimensional printer), breast cup-fitting apparatus, breast cup-holding device (to ensure the breast remains lifted in the supine position), and dedicated stretcher fixed to the WBIS (to carry the patient). We conducted a phantom experiment to evaluate the effect of the HyBIS on breast immobilization during the respiratory cycle. Thirteen markers were embedded in the right breast of a female phantom that simulated respiratory thoracic movement at an amplitude of 15 mm, and their displacements on four-dimensional computed tomography were compared between conditions with and without immobilization by HyBIS. When immobilization was applied with the HyBIS, breast protrusion was maintained in the phantom in the supine treatment position. The mean values of the anteroposterior, superoinferior, lateral, and three-dimensional (3D) displacement of the markers were 2.7 ± 1.7, 0.3 ± 0.5, 0.9 ± 0.8, and 3.1 ± 1.6 mm with HyBIS, and 5.5 ± 2.9, 0.6 ± 0.8, 0.5 ± 0.4, and 5.6 ± 2.9 mm without HyBIS, respectively; thus, the anteroposterior (P = 0.014) and 3D (P = 0.007) displacements significantly improved with HyBIS. We demonstrated that the HyBIS can help retain the protruded breast shape in the supine position during treatment and can reduce the influence of respiratory movement. Thus, the HyBIS can help to reliably and precisely perform PBT for EBC. © 2017 American Association of Physicists in Medicine.

  20. A Digital Library Feasibility Study

    Directory of Open Access Journals (Sweden)

    C. Henshaw

    2010-08-01

    Full Text Available This paper presents the outcomes of a Digital Library Feasibility Study at the Wellcome Library. In particular, the study looked at the interoperability and integration between systems, including a back-end digital asset management (DAM system with attached storage, a front-end delivery system, the use of METS to manage delivery of content, a full-text database with search engine, and a workflow management system.

  1. Feasibility of central meditation and imagery therapy for dementia caregivers.

    Science.gov (United States)

    Jain, Felipe A; Nazarian, Nora; Lavretsky, Helen

    2014-08-01

    Family dementia caregivers are at high risk of depression and burnout. We assessed the feasibility of Central Meditation and Imagery Therapy for Caregivers (CMIT-C), a novel 8-week group meditation and guided imagery group therapy program, for dementia caregivers reporting stress because of caregiving responsibilities. Twelve family dementia caregivers enrolled in CMIT-C. Primary outcomes included depression and anxiety, and secondary outcomes included insomnia, quality of life, and mindfulness. Changes over the study and 3 month follow-up were analyzed with non-parametric related samples tests. Correlations of feeling state changes from meditation diaries at 1 week were made with symptom changes post meditation training. Ten participants completed the study. Completers came to an average of 7 ± 1 sessions out of a possible 8 sessions, and turned in home practice logs of 90 ± 10% of the time. Anxiety, depression, and insomnia symptoms decreased, and mindfulness ratings improved with large effects (all p meditation practice was associated with subsequent home meditation practice, anxiety change at 8 weeks, and endpoint satisfaction with CMIT-C. Central Meditation and Imagery Therapy for Caregivers is a feasible intervention for dementia caregivers. Results suggest that this therapeutic technique can reduce symptoms of anxiety, depression, and insomnia, and increase levels of mindfulness. Early response to meditation practice predicted those with the greatest short-term benefits, and this may inform future studies of meditation. Larger controlled efficacy studies of CMIT-C for dementia caregivers are warranted. Copyright © 2014 John Wiley & Sons, Ltd.

  2. Exploring Acceptability and Feasibility of Evidence-Based Practice in Child Welfare Settings: A Pilot Study with Attachment-Based Family Therapy

    Directory of Open Access Journals (Sweden)

    Tara Santens

    2017-04-01

    Full Text Available The Flemish Child Welfare System (CWS is in great need of a shared empirically informed clinical strategy for working with depressed adolescents and their families. Many evidence-based practices (EBP exist, but little is known as to whether they can be successfully imported in the CWS. Therefore, the current study explores the implementation of a particular EBP, Attachment-Based Family Therapy (ABFT, in home-based services of the Flemish CWS in Belgium. Specifically, the study focused on (1 the acceptability of ABFT by counselors and whether negative attitudes about EBP can be changed ('n' = 73 counselors, and (2 the feasibility of implementing ABFT ('n' = 43 adolescents, 11–17 years old, 72% female by exploring initial effectiveness. The results suggest that (1 initial negative attitudes of counselors towards ABFT were significantly more positive after attending training and discussions about ABFT, and that (2 ABFT could be used by counselors to successfully reduce adolescent depressive symptoms. Future research should include a control group to draw stronger causal conclusions. Strengths and limitations of the study’s design and implications for further dissemination are discussed.

  3. The effect of group music therapy on mood, speech, and singing in individuals with Parkinson's disease--a feasibility study.

    Science.gov (United States)

    Elefant, Cochavit; Baker, Felicity A; Lotan, Meir; Lagesen, Simen Krogstie; Skeie, Geir Olve

    2012-01-01

    Parkinson's disease (PD) is a progressive neurodegenerative disorder where patients exhibit impairments in speech production. Few studies have investigated the influence of music interventions on vocal abilities of individuals with PD. To evaluate the influence of a group voice and singing intervention on speech, singing, and depressive symptoms in individuals with PD. Ten patients diagnosed with PD participated in this one-group, repeated measures design study. Participants received the sixty-minute intervention, in a small group setting once a week for 20 consecutive weeks. Speech and singing quality were acoustically analyzed using a KayPentax Multi-Dimensional Voice Program, voice ability using the Voice Handicap Index (VHI), and depressive symptoms using the Montgomery and Asberg Depression rating scale (MADRS). Measures were taken at baseline (Time 1), after 10 weeks of weekly sessions (Time 2), and after 20 weeks of weekly sessions (Time 3). Significant changes were observed for five of the six singing quality outcomes at Time 2 and 3, as well as voice range and the VHI physical subscale at Time 3. No significant changes were found for speaking quality or depressive symptom outcomes; however, there was an absence of decline on speaking quality outcomes over the intervention period. Significant improvements in singing quality and voice range, coupled with the absence of decline in speaking quality support group singing as a promising intervention for persons with PD. A two-group randomized control study is needed to determine whether the intervention contributes to maintenance of speaking quality in persons with PD.

  4. MO-FG-CAMPUS-JeP3-04: Feasibility Study of Real-Time Ultrasound Monitoring for Abdominal Stereotactic Body Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Su, Lin; Kien Ng, Sook; Zhang, Ying; Herman, Joseph; Wong, John; Ding, Kai [Department of Radiation Oncology, John Hopkins University, Baltimore, MD (United States); Ji, Tianlong [Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning (China); Iordachita, Iulian [Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD (United States); Tutkun Sen, H.; Kazanzides, Peter; Lediju Bell, Muyinatu A. [Department of Computer Science, Johns Hopkins University, Baltimore, MD (United States)

    2016-06-15

    Purpose: Ultrasound is ideal for real-time monitoring in radiotherapy with high soft tissue contrast, non-ionization, portability, and cost effectiveness. Few studies investigated clinical application of real-time ultrasound monitoring for abdominal stereotactic body radiation therapy (SBRT). This study aims to demonstrate the feasibility of real-time monitoring of 3D target motion using 4D ultrasound. Methods: An ultrasound probe holding system was designed to allow clinician to freely move and lock ultrasound probe. For phantom study, an abdominal ultrasound phantom was secured on a 2D programmable respiratory motion stage. One side of the stage was elevated than another side to generate 3D motion. The motion stage made periodic breath-hold movement. Phantom movement tracked by infrared camera was considered as ground truth. For volunteer study three healthy subjects underwent the same setup for abdominal SBRT with active breath control (ABC). 4D ultrasound B-mode images were acquired for both phantom and volunteers for real-time monitoring. 10 breath-hold cycles were monitored for each experiment. For phantom, the target motion tracked by ultrasound was compared with motion tracked by infrared camera. For healthy volunteers, the reproducibility of ABC breath-hold was evaluated. Results: Volunteer study showed the ultrasound system fitted well to the clinical SBRT setup. The reproducibility for 10 breath-holds is less than 2 mm in three directions for all three volunteers. For phantom study the motion between inspiration and expiration captured by camera (ground truth) is 2.35±0.02 mm, 1.28±0.04 mm, 8.85±0.03 mm in LR, AP, SI directly, respectively. The motion monitored by ultrasound is 2.21±0.07 mm, 1.32±0.12mm, 9.10±0.08mm, respectively. The motion monitoring error in any direction is less than 0.5 mm. Conclusion: The volunteer study proved the clinical feasibility of real-time ultrasound monitoring for abdominal SBRT. The phantom and volunteer ABC

  5. Response assessment of bevacizumab therapy in GBM with integrated 11C-MET-PET/MRI: a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Deuschl, Cornelius [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); University of Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Duisburg (Germany); Moenninghoff, Christoph; Goericke, Sophia; Forsting, Michael; Umutlu, Lale [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Kirchner, Julian [University Hospital Duesseldorf, Institute of Diagnostic and Interventional Radiology, Duesseldorf (Germany); Koeppen, Susanne [University Hospital Essen, Department of Neurology, Essen (Germany); Binse, Ina; Poeppel, Thorsten D.; Herrmann, Ken [University Hospital Essen, Department of Nuclear Medicine, Essen (Germany); Quick, Harald H. [University of Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Duisburg (Germany); University Hospital Essen, High Field and Hybrid MR Imaging, Essen (Germany); Hense, Joerg [University Hospital Essen, Department of Medical Oncology, West German Cancer Center, Essen (Germany); Schlamann, Marc [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); University Hospital Giessen, Department of Neuroradiology, Essen (Germany)

    2017-08-15

    The objective of this study was to evaluate the potential of integrated 11C-MET PET/MR for response assessment of relapsed glioblastoma (GBM) receiving bevacizumab treatment. Eleven consecutive patients with relapsed GBM were enrolled for an integrated 11C-MET PET/MRI at baseline and at follow-up. Treatment response for MRI was evaluated according to Response Assessment in Neuro-oncology (RANO) criteria and integrated 11C-MET PET was assessed by the T/N ratio. MRI showed no patient with complete response (CR), six of 11 patients with PR, four of 11 patients with SD, and one of 11 patients with progressive disease (PD). PET revealed metabolic response in five of the six patients with partial response (PR) and in two of the four patients with stable disease (SD), whereas metabolic non-response was detected in one of the six patients with PR, in two of the four patients with SD, and in the one patient with PD. Morphological imaging was predictive for PFS and OS when response was defined as CR, PR, SD, and non-response as PD. Metabolic imaging was predictive when using T/N ratio reduction of >25 as discriminator. Based on the morphologic and metabolic findings of this study a proposal for applying integrated PET/MRI for treatment response in relapsed GBM was developed, which was significantly predictive for PFS and OS (P = 0.010 respectively 0,029, log). This study demonstrates the potential of integrated 11C-MET-PET/MRI for response assessment of GBM and the utility of combined assessment of morphologic and metabolic information with the proposal for assessing relapsed GBM. (orig.)

  6. Feasibility of a Trial on Improvisational Music Therapy for Children with Autism Spectrum Disorder

    DEFF Research Database (Denmark)

    Geretsegger, Monika; Holck, Ulla; Bieleninik, Łucja

    2016-01-01

    and strategies to facilitate study implementation is available in the music therapy literature. Objective: Using data from a subsample of a multi-center RCT on improvisational music therapy (IMT) for autism spectrum disorder (ASD), this study aims to evaluate feasibility of study procedures, evaluate safety...

  7. Manzanita Wind Energy Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Trisha Frank

    2004-09-30

    The Manzanita Indian Reservation is located in southeastern San Diego County, California. The Tribe has long recognized that the Reservation has an abundant wind resource that could be commercially utilized to its benefit. Manzanita has explored the wind resource potential on tribal land and developed a business plan by means of this wind energy feasibility project, which enables Manzanita to make informed decisions when considering the benefits and risks of encouraging large-scale wind power development on their lands. Technical consultant to the project has been SeaWest Consulting, LLC, an established wind power consulting company. The technical scope of the project covered the full range of feasibility assessment activities from site selection through completion of a business plan for implementation. The primary objectives of this feasibility study were to: (1) document the quality and suitability of the Manzanita Reservation as a site for installation and long-term operation of a commercially viable utility-scale wind power project; and, (2) develop a comprehensive and financeable business plan.

  8. Group Metacognitive Therapy vs. Mindfulness Meditation Therapy in a Transdiagnostic Patient Sample: A Randomised Feasibility Trial.

    Science.gov (United States)

    Capobianco, Lora; Reeves, David; Morrison, Anthony P; Wells, Adrian

    2018-01-01

    Two transdiagnostic therapies for treating psychological disorder are Metacognitive Therapy (MCT) and Mindfulness Based Stress Reduction (MBSR). These two approaches have yet to be compared and therefore the current study aimed to evaluate the feasibility of a study of group MCT and MBSR in treating anxiety and depression. A feasibility trial with 40 participants (aged 19-56) was conducted. Patients were randomly assigned to receive either eight weeks of group MCT or MBSR. The primary outcome was feasibility which included recruitment rates, retention and treatment acceptability. The primary symptom outcome was the Hospital Anxiety and Depression Scale (HADS) total score, which provided an overall measure of distress. Both treatments were found to be acceptable with low attrition and similar ratings of acceptability. Changes in outcomes were analyzed based on the intention-to-treat principle using mixed effect models. Preliminary analyses revealed that MCT was more effective in treating anxiety and depression in comparison to MBSR, and in reducing both positive and negative metacognitive beliefs. Reliable improvement rates favoured MCT at post-treatment and 6-month follow up. Both treatments appeared to be feasible and acceptable in treating transdiagnostic samples; however, a larger, definitive trial is required. The limitations and directions for future research are discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. SU-E-T-21: A D-D Based Neutron Generator System for Boron Neutron Capture Therapy: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Hsieh, M; Liu, Y; Nie, L [Purdue University, West Lafayette, IN (United States)

    2015-06-15

    Purpose: To investigate the feasibility of a deuterium-deuterium (DD) neutron generator for application in boron neutron capture therapy (BNCT) of brain cancer Methods: MCNP simulations were performed using a head phantom and a monoenergetic neutron source, which resembles the point source in a DD generator that emits 2.45-MeV neutrons. Source energies ranging from 5eV to 2.45MeV were simulated to determine the optimal treatment energy. The phantom consisted of soft tissue, brain tissue, skull, skin layer, and a brain tumor of 5 cm in diameter. Tumor depth was varied from 5–10 cm. Boron-10 concentrations of 10 ppm, 15 ppm, and 30 ppm were used in the soft/brain tissues, skin, and tumor, respectively. The neutron flux required to deliver 60 Gy to the tumor as well as the normal tissue doses were determined. Results: Beam energies between 5eV and 10keV obtained doses with the highest dose ratios (3.3–25.9) between the tumor and the brain at various depths. The dose ratio with 2.45-MeV neutrons ranged from 0.8–6.6. To achieve the desired tumor dose in 40 minutes, the required neutron flux for a DD generator was between 8.8E10 and 5.2E11 n/s and the resulting brain dose was between 2.3 and 18 Gy, depending on the tumor depth. The skin and soft tissue doses were within acceptable tolerances. The boron-neutron interaction accounted for 54–58% of the total dose. Conclusion: This study shows that the DD neutron generator can be a feasible neutron source for BNCT. The required neutron flux for treatment is achievable with the current DD neutron technology. With a well-designed beam shaping assembly and treatment geometry, the neutron flux can be further improved and a 60-Gy prescription can be accurately delivered to the target while maintaining tolerable normal tissue doses. Further experimental studies will be developed and conducted to validate the simulation results.

  10. DPC loading feasibility study report

    Energy Technology Data Exchange (ETDEWEB)

    Dafoe, R.E.; Lopez, D.A.; Williams, K.L.

    1997-11-01

    Disposal of radioactive wastes now stored at the Idaho Chemical Processing Plant at the Idaho National Engineering and Environmental Laboratory is mandated under a ``Settlement Agreement`` between the Department of Energy and the State of Idaho. This study investigates the feasibility of using the Dry Transfer Cell facility to package waste into Dual Purpose Canisters for interim storage at the adjacent Dry Storage System comprised of an interim storage pad with NUHOMS{reg_sign} storage modules. The wastes would then be road-ready for eventual disposal in a permanent repository. The operating period for these activities is expected to be from 2015 to 2035.

  11. A feasibility pilot study on the use of complementary therapies delivered via mobile technologies on Icelandic surgical patients' reports of anxiety, pain, and self-efficacy in healing.

    Science.gov (United States)

    Hansen, Margaret M

    2015-03-28

    Complementary therapies (CT), such as relaxation technique, massage, guided imagery, and accupuncture have shown to benefit patients undergoing surgery. The aim of this study was to determine the feasibility of using audio relaxation technique (ART), music intervention (MI), nature video application with music (NVAM), and nature video application without music (NVA) delivered via mobile technologies in a clinical setting. Secondary, the effects of ART, MI, NVAM and NVA on patients' state anxiety, pain perception, and perceived self-efficacy in healing were determined. A randomized clinical trial (RCT) involving 105 same day surgery (SDS) patients, who were assigned to an ART (n = 25), MI (n = 25), NVAM (n = 15), NVA (n = 16), or a control group (n = 24) were assessed for state anxiety, self-reported pain, and self-efficacy four days prior to surgery, immediately prior and following a surgical intervention, and day five post-operative. ANOVA found no statistically significant differences in anxiety scores; pain, or perceived self-efficacy between the five groups. Matched pairs t-Test revealed all participants had an increase in anxiety from pre-op to day 10 follow-up; a significant change in pain levels from pre-op to day 10 follow-up; and all participants had a significant increase in general self-efficacy from pre-op to day 10 follow-up. Mean pain level scores from day 1 to pre-op showed a significant decrease in pain for the ART group and NVAM group. Matched pairs t-Test for self-efficacy scores indicated the MI group and the NVA group had significant increases in self-efficacy. A significant decrease in anxiety from pre-op to day 10 for participants reporting a prior history of anxiety and for those reporting prior history of taking anti-anxiety medications. Despite the non-significant findings between the five groups, at any measurement point, there were valuable trends toward significance and confirmed feasibility in a clinical setting

  12. Feasibility and Safety of Physical Therapy during Continuous Renal Replacement Therapy in the Intensive Care Unit.

    Science.gov (United States)

    Toonstra, Amy L; Zanni, Jennifer M; Sperati, C John; Nelliot, Archana; Mantheiy, Earl; Skinner, Elizabeth H; Needham, Dale M

    2016-05-01

    Early rehabilitation in an intensive care unit is associated with improved physical functioning and patient outcomes. However, relatively few data have been reported on physical therapy interventions during continuous renal replacement therapy (CRRT) for patients in intensive care units. To evaluate the feasibility and safety of physical therapy interventions, delivered as part of routine clinical care, for patients undergoing CRRT in an intensive care unit. Consecutive patients in the adult medical intensive care unit of one large tertiary care hospital who received physical therapy sessions while on CRRT were prospectively evaluated over 13 months. Physical therapy sessions were individualized on the basis of patients' physical impairments and activity tolerance, with patients' highest level of mobility recorded. Data on 15 different physiological abnormalities and potential safety events, including bleeding, dislodgement, or dysfunction of the CRRT catheter or circuit, were prospectively collected. Eleven physical therapists delivered 268 rehabilitation sessions to 57 patients while they were receiving CRRT, with the following highest levels of mobility achieved during individual sessions: 78 (29%) bed exercises, 72 (27%) supine cycle ergometry, 80 (30%) sitting at edge of bed, 13 (5%) transfer to chair, and 25 (9%) standing or marching in place. No CRRT-specific safety events occurred (0%; 95% upper confidence interval, 6.3%). There were six non-CRRT-related potential safety events (2.2% of all physical therapy sessions; 95% confidence interval, 0.6-8.2%), all of which were transient changes in blood pressure. In this prospective observational study at one adult medical intensive care unit, we found that provision of bedside physical therapy while patients underwent CRRT is feasible, and appears safe.

  13. IPNS upgrade: A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    Many of Argonne National Laboratory`s (ANL`s) scientific staff members were very active in R&D work related to accelerator-based spoliation sources in the 1970s and early 1980s. In 1984, the Seitz/Eastman Panel of the National Academy of Sciences reviewed U.S. materials science research facilities. One of the recommendations of this panel was that the United States build a reactor-based steady-state source, the Advanced Neutron Source (ANS), at Oak Ridge National Laboratory. Subsequently, R&D activities related to the design of an accelerator-based source assumed a lower priority. The resumption of pulsed-source studies in this country started simultaneously with design activities in Europe aimed at the European Spallation Source (ESS). The European Community funded a workshop in September 1991 to define the parameters of the ESS. Participants in this workshop included both accelerator builders and neutron source users. A consortium of European countries has proposed to build a 5-MW pulsed source, and a feasibility study is currently under way. Soon after the birth of the ESS, a small group at ANL set about bringing themselves up to date on pulsed-source information since 1984 and studied the feasibility of upgrading ANL`s Intense Pulsed Neutron Source (IPNS) to 1 MW by means of a rapidly cycling synchrotron that could be housed, along with its support facilities, in existing buildings. In early 1993, the Kohn panel recommended that (1) design and construction of the ANS should be completed according to the proposed project schedule and (2) development of competitive proposals for cost-effective design and construction of a 1-MW pulsed spallation source should be authorized immediately.

  14. The feasibility of incorporating Vpx into lentiviral gene therapy vectors

    Directory of Open Access Journals (Sweden)

    Samantha A McAllery

    2016-01-01

    Full Text Available While current antiretroviral therapy has significantly improved, challenges still remain in life-long targeting of HIV-1 reservoirs. Lentiviral gene therapy has the potential to deliver protective genes into the HIV-1 reservoir. However, inefficient reverse transcription (RT occurs in HIV-1 reservoirs during lentiviral gene delivery. The viral protein Vpx is capable of increasing lentiviral RT by antagonizing the restriction factor SAMHD1. Incorporating Vpx into lentiviral vectors could substantially increase gene delivery into the HIV-1 reservoir. The feasibility of this Vpx approach was tested in resting cell models utilizing macrophages and dendritic cells. Our results showed Vpx exposure led to increased permissiveness of cells over a period that exceeded 2 weeks. Consequently, significant lower potency of HIV-1 antiretrovirals inhibiting RT and integration was observed. When Vpx was incorporated with anti-HIV-1 genes inhibiting either pre-RT or post-RT stages of the viral life-cycle, transduction levels significantly increased. However, a stronger antiviral effect was only observed with constructs that inhibit pre-RT stages of the viral life cycle. In conclusion this study demonstrates a way to overcome the major delivery obstacle of gene delivery into HIV-1 reservoir cell types. Importantly, incorporating Vpx with pre-RT anti-HIV-1 genes, demonstrated the greatest protection against HIV-1 infection.

  15. SU-D-207A-04: Use of Gradient Echo Plural Contrast Imaging (GEPCI) in MR-Guided Radiation Therapy: A Feasibility Study Targeting Brain Treatment

    Energy Technology Data Exchange (ETDEWEB)

    Cai, B; Rao, Y; Tsien, C; Huang, J; Green, O; Mutic, S; Gach, H [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States); Wen, J; Yablonskiy, D [Department of Radiology, Washington University School of Medicine, St Louis, MO (United States)

    2016-06-15

    Purpose: To implement the Gradient Echo Plural Contrast Imaging(GEPCI) technique in MRI-simulation for radiation therapy and assess the feasibility of using GEPCI images with advanced inhomogeneity correction in MRI-guided radiotherapy for brain treatment. Methods: An optimized multigradient-echo GRE sequence (TR=50ms;TE1=4ms;delta-TE=4ms;flip angle=300,11 Echoes) was developed to generate both structural (T1w and T2*w) and functional MRIs (field and susceptibility maps) from a single acquisition. One healthy subject (Subject1) and one post-surgical brain cancer patient (Subject2) were scanned on a Philips Ingenia 1.5T MRI used for radiation therapy simulation. Another healthy subject (Subject3) was scanned on a 0.35T MRI-guided radiotherapy (MR-IGRT) system (ViewRay). A voxel spread function (VSF) was used to correct the B0 inhomogeneities caused by surgical cavities and edema for Subject2. GEPCI images and standard radiotherapy planning MRIs for this patient were compared focusing the delineation of radiotherapy target region. Results: GEPCI brain images were successfully derived from all three subjects with scan times of <7 minutes. The images derived for Subjects1&2 demonstrated that GEPCI can be applied and combined into radiotherapy MRI simulation. Despite low field, T1-weighted and R2* images were successfully reconstructed for Subject3 and were satisfactory for contour and target delineation. The R2* distribution of grey matter (center=12,FWHM=4.5) and white matter (center=14.6, FWHM=2) demonstrated the feasibility for tissue segmentation and quantification. The voxel spread function(VSF) corrected surgical site related inhomogeneities for Subject2. R2* and quantitative susceptibility map(QSM) images for Subject2 can be used to quantitatively assess the brain structure response to radiation over the treatment course. Conclusion: We implemented the GEPCI technique in MRI-simulation and in MR-IGRT system for radiation therapy. The images demonstrated that it

  16. Use of mobile device technology to continuously collect patient-reported symptoms during radiation therapy for head and neck cancer: A prospective feasibility study

    Directory of Open Access Journals (Sweden)

    Aaron D. Falchook, MD

    2016-04-01

    Conclusions: A substantial percentage of patients used mobile devices to continuously report symptoms throughout a course of radiation therapy for head and neck cancer. Future studies should evaluate the impact of mobile device symptom reporting on improving patient outcomes.

  17. SU-E-T-33: A Feasibility-Seeking Algorithm Applied to Planning of Intensity Modulated Proton Therapy: A Proof of Principle Study

    Energy Technology Data Exchange (ETDEWEB)

    Penfold, S [University of Adelaide, Adelaide, SA (Australia); Casiraghi, M [Paul Scherrer Institut, Villigen, Aargau (Switzerland); Dou, T [University of California, Los Angeles, Los Angeles, CA (United States); Schulte, R [Loma Linda University, Loma Linda, CA (United States); Censor, Y [University of Haifa, Haifa (Israel)

    2015-06-15

    Purpose: To investigate the applicability of feasibility-seeking cyclic orthogonal projections to the field of intensity modulated proton therapy (IMPT) inverse planning. Feasibility of constraints only, as opposed to optimization of a merit function, is less demanding algorithmically and holds a promise of parallel computations capability with non-cyclic orthogonal projections algorithms such as string-averaging or block-iterative strategies. Methods: A virtual 2D geometry was designed containing a C-shaped planning target volume (PTV) surrounding an organ at risk (OAR). The geometry was pixelized into 1 mm pixels. Four beams containing a subset of proton pencil beams were simulated in Geant4 to provide the system matrix A whose elements a-ij correspond to the dose delivered to pixel i by a unit intensity pencil beam j. A cyclic orthogonal projections algorithm was applied with the goal of finding a pencil beam intensity distribution that would meet the following dose requirements: D-OAR < 54 Gy and 57 Gy < D-PTV < 64.2 Gy. The cyclic algorithm was based on the concept of orthogonal projections onto half-spaces according to the Agmon-Motzkin-Schoenberg algorithm, also known as ‘ART for inequalities’. Results: The cyclic orthogonal projections algorithm resulted in less than 5% of the PTV pixels and less than 1% of OAR pixels violating their dose constraints, respectively. Because of the abutting OAR-PTV geometry and the realistic modelling of the pencil beam penumbra, complete satisfaction of the dose objectives was not achieved, although this would be a clinically acceptable plan for a meningioma abutting the brainstem, for example. Conclusion: The cyclic orthogonal projections algorithm was demonstrated to be an effective tool for inverse IMPT planning in the 2D test geometry described. We plan to further develop this linear algorithm to be capable of incorporating dose-volume constraints into the feasibility-seeking algorithm.

  18. Muon muon collider: Feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-18

    A feasibility study is presented of a 2 + 2 TeV muon collider with a luminosity of L = 10{sup 35} cm{sup {minus}2} s{sup {minus}1}. The resulting design is not optimized for performance, and certainly not for cost; however, it does suffice--the authors believe--to allow them to make a credible case, that a muon collider is a serious possibility for particle physics and, therefore, worthy of R and D support so that the reality of, and interest in, a muon collider can be better assayed. The goal of this support would be to completely assess the physics potential and to evaluate the cost and development of the necessary technology. The muon collider complex consists of components which first produce copious pions, then capture the pions and the resulting muons from their decay; this is followed by an ionization cooling channel to reduce the longitudinal and transverse emittance of the muon beam. The next stage is to accelerate the muons and, finally, inject them into a collider ring which has a small beta function at the colliding point. This is the first attempt at a point design and it will require further study and optimization. Experimental work will be needed to verify the validity of diverse crucial elements in the design.

  19. Feasibility study of a combined treatment of electromyography-triggered neuromuscular stimulation and mirror therapy in stroke patients: a randomized crossover trial.

    Science.gov (United States)

    Kojima, Kosuke; Ikuno, Koki; Morii, Yuta; Tokuhisa, Kentaro; Morimoto, Shigeru; Shomoto, Koji

    2014-01-01

    Mirror therapy (MT) and electromyography-triggered neuromuscular stimulation (ETMS) are both effective treatments for impaired upper limbs following stroke. A combination of these two treatments (ETMS-MT) may result in greater gain than either treatment alone. The feasibility and possible effects of ETMS-MT upon upper extremity function were investigated in stroke patients. Thirteen post-acute stroke patients were randomly assigned to an immediate ETMS-MT group or a delayed ETMS-MT group and then underwent an 8-week training program. The immediate ETMS-MT group received ETMS-MT in addition to physical and occupational therapy (PT+OT) for 4 weeks. They then received only PT+OT for the next 4 weeks. In the delayed ETMS-MT group, interventions were provided in the reverse order. The main outcome measure was the Fugl-Meyer Assessment (FMA). The immediate ETMS-MT group showed significantly greater gain in FMA in the first 4 weeks. The delayed ETMS-MT group showed significantly greater gain in active range of motion during the latter 4 weeks. No adverse effects were reported following ETMS-MT. ETMS-MT might be as effective as independent MT or ETMS without causing any side effects. Future research should focus upon the direct comparisons between independent and combined interventions.

  20. Feasibility, acceptability, and potential effectiveness of dignity therapy for people with motor neurone disease.

    Directory of Open Access Journals (Sweden)

    Brenda Bentley

    Full Text Available BACKGROUND: Motor neurone disease (MND practice guidelines suggest developing interventions that will promote hope, meaning, and dignity to alleviate psychological distress, but very little research has been done. This study begins to address this need by exploring the use of dignity therapy with people with MND. Dignity therapy is a brief psychotherapy that promotes hope, meaning and dignity, and enhances the end of life for people with advanced cancer. The aims of this study are to assess the feasibility, acceptability, and potential effectiveness of dignity therapy for people with MND. METHODS/DESIGN: This cross-sectional feasibility study used a one-group pre-test post-test design with 29 people diagnosed with MND. Study participants completed the following self-report questionnaires: Herth Hope Index, FACIT-sp, Patient Dignity Inventory, ALS Assessment Questionnaire, ALS Cognitive Behavioural Screen, and a demographic and health history questionnaire. Acceptability was measured with a 25-item feedback questionnaire. Feasibility was assessed by examining the length of time taken to complete dignity therapy and how symptoms common in MND affected the intervention. Generalised linear mixed models and reliable change scores were used to analyse the data. RESULTS: There were no significant pre-test post-test changes for hopefulness, spirituality or dignity on the group level, but there were changes in hopefulness on the individual level. The results of the feedback questionnaire indicates dignity therapy is highly acceptable to people with MND, who report benefits similar to those in the international randomised controlled trial on dignity therapy, a population who primarily had end-stage cancer. Benefits include better family relationships, improved sense of self and greater acceptance. Dignity therapy with people with MND is feasible if the therapist can overcome time and communication difficulties. CONCLUSIONS: Dignity therapy for people with

  1. Feasibility, Safety, and Compliance in a Randomized Controlled Trial of Physical Therapy for Parkinson's Disease

    Directory of Open Access Journals (Sweden)

    Jennifer L. McGinley

    2012-01-01

    Full Text Available Both efficacy and clinical feasibility deserve consideration in translation of research outcomes. This study evaluated the feasibility of rehabilitation programs within the context of a large randomized controlled trial of physical therapy. Ambulant participants with Parkinson's disease (PD (n=210 were randomized into three groups: (1 progressive strength training (PST; (2 movement strategy training (MST; or (3 control (“life skills”. PST and MST included fall prevention education. Feasibility was evaluated in terms of safety, retention, adherence, and compliance measures. Time to first fall during the intervention phase did not differ across groups, and adverse effects were minimal. Retention was high; only eight participants withdrew during or after the intervention phase. Strong adherence (attendance >80% did not differ between groups (P=.435. Compliance in the therapy groups was high. All three programs proved feasible, suggesting they may be safely implemented for people with PD in community-based clinical practice.

  2. Dual-Doppler Feasibility Study

    Science.gov (United States)

    Huddleston, Lisa L.

    2012-01-01

    When two or more Doppler weather radar systems are monitoring the same region, the Doppler velocities can be combined to form a three-dimensional (3-D) wind vector field thus providing for a more intuitive analysis of the wind field. A real-time display of the 3-D winds can assist forecasters in predicting the onset of convection and severe weather. The data can also be used to initialize local numerical weather prediction models. Two operational Doppler Radar systems are in the vicinity of Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS); these systems are operated by the 45th Space Wing (45 SW) and the National Weather Service Melbourne, Fla. (NWS MLB). Dual-Doppler applications were considered by the 45 SW in choosing the site for the new radar. Accordingly, the 45th Weather Squadron (45 WS), NWS MLB and the National Aeronautics and Space Administration tasked the Applied Meteorology Unit (AMU) to investigate the feasibility of establishing dual-Doppler capability using the two existing systems. This study investigated technical, hardware, and software requirements necessary to enable the establishment of a dual-Doppler capability. Review of the available literature pertaining to the dual-Doppler technique and consultation with experts revealed that the physical locations and resulting beam crossing angles of the 45 SW and NWS MLB radars make them ideally suited for a dual-Doppler capability. The dual-Doppler equations were derived to facilitate complete understanding of dual-Doppler synthesis; to determine the technical information requirements; and to determine the components of wind velocity from the equation of continuity and radial velocity data collected by the two Doppler radars. Analysis confirmed the suitability of the existing systems to provide the desired capability. In addition, it is possible that both 45 SW radar data and Terminal Doppler Weather Radar data from Orlando International Airport could be used to alleviate any

  3. Multnomah County Hydrokinetic Feasibility Study: Final Feasibility Study Report

    Energy Technology Data Exchange (ETDEWEB)

    Spain, Stephen

    2012-03-15

    HDR has completed a study of the technical, regulatory, and economic feasibility of installing hydrokinetic turbines under the Morrison, Broadway, and Sellwood bridges. The primary objective of installing hydrokinetic turbines is a demonstration of in-stream hydrokinetic technologies for public education and outreach. Due to the low gradient of the Lower Willamette and the effects of the tide, velocities in the area in consideration are simply not high enough to economically support a commercial installation. While the velocities in the river may at times provide enough energy for a commercial turbine to reach capacity, the frequency and duration of high flow events which provide suitable velocities is not sufficient to support a commercial hydrokinetic installation. We have observed that over an 11 year period, daily average velocities in the Lower Willamette exceeded a nominal cut-in speed of 0.75 m/s only 20% of the time, leaving net zero power production for the remaining 80% of days. The Sellwood Bridge site was estimated to have the best hydrokinetic resource, with an estimated average annual production of about 9,000 kWh. The estimated production could range from 2,500 kWh to 15,000 kWh. Based on these energy estimates, the amount of revenue generated through either a power purchase agreement (PPA) or recovered through net metering is not sufficient to repay the project costs within the life of the turbine. The hydrokinetic resource at the Morrison and Broadway Bridges is slightly smaller than at the Sellwood Bridge. While the Broadway and Morrison Bridges have existing infrastructure that could be utilized, the project is not expected to generate enough revenue to repay the investment. Despite low velocities and energy production, the sites themselves are favorable for installation of a demonstration or experimental project. With high public interest in renewable energy, the possibility exists to develop a hydrokinetic test site which could provide

  4. Dance therapy combined with patient education improves quality of life of persons with obesity: A pilot feasibility study for a randomised controlled trial.

    Science.gov (United States)

    Allet, Lara; Müller-Pinget, Solange; Punt, Ilona; Edelsten, Charlotte; Ballif, Aurélie; Golay, Alain; Pataky, Zoltan

    To assess the effect of dance therapy combined with patient education on quality of life, functional capacity (lower limb power and endurance) and physical activity level in obese individuals. Thirty-three obese patients were randomised to a control group (structured patient education ambulatory program), and 34 to an intervention group (structured patient education ambulatory program combined with weekly sessions of dance therapy). Patients' quality of life, physical function and physical activity level were assessed at baseline and after 16 weeks. Almost only women were willing to enrol in the study. Participants of the intervention group significantly improved their quality of life (p=0.023), and particularly self-esteem (p=0.014). However, dance therapy added to a patient educational program did not produce statistically significant higher effects than a patient education program alone on functional capacities and patients' physical activity level. A 16 week structured patient educational program combined with dance therapy seems to have a positive effect on the quality of life of obese people, but no effect on functional capacities and physical activity. Dance therapy combined with structured patient education is an interesting approach to improve quality of life of obese people. Copyright © 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

  5. WERF MACT Feasibility Study Report

    Energy Technology Data Exchange (ETDEWEB)

    B. Bonnema; D. Moser; J. Riedesel; K. Kooda; K. Liekhus; K. Rebish; S. Poling

    1998-11-01

    This study was undertaken to determine the technical feasibility of upgrading the Waste Experimental Reduction Facility (WERF) at the Idaho National Engineering and Environmental Laboratory to meet the offgas emission limits proposed in the Maximum Achievable Control Technologies (MACT)rule. Four practicable offgas treatment processes were identified, which, if installed, would enable the WERF to meet the anticipated MACT emission limits for dioxins and furans (D/F), hydrochloric acid (HCI), and mercury (Hg). Due to the three-year time restraint for MACT compliance, any technology chosen for the upgrade must be performed within the general plant project funding limit of $5 M. The option selected consists of a partial-quench evaporative cooler with dry sorbent injection for HCI removal followed by a sulfur-impregnated activated carbon bed for Hg control. The planning cost estimate for implementing the option is $4.17 M (with 24% contingency). The total estimated cost includes capital costs, design and construction costs, and project management costs. Capital costs include the purchase of a new offgas evaporative cooler, a dry sorbent injection system with reagent storage, a new fabric filter baghouse, a fixed carbon bed absorber, and two offgas induced draft exhaust fans. It is estimated that 21 months will be required to complete the recommended modification to the WERF. The partial-quench cooler is designed to rapidly cool the offgas exiting the secondary combustion chamber to minimize D/F formation. Dry sorbent injection of an alkali reagent into the offgas is recommended. The alkali reacts with the HCI to form a salt, which is captured with the fly ash in the baghouse. A design HCI removal efficiency of 97.2% allows for the feeding 20 lbs/hr of chlorine to the WERF incinerator. The sorbent feed rate can be adjusted to achieve the desired HCI removal efficiency. A fixed bed of sulfur-impregnated carbon was conservatively sized for a total Hg removal capacity when

  6. Feasibility study on the effectiveness of Goreisan-based Kampo therapy for lower abdominal lymphedema after retroperitoneal lymphadenectomy via extraperitoneal approach.

    Science.gov (United States)

    Komiyama, Shinichi; Takeya, Chiaki; Takahashi, Rena; Yamamoto, Yasuhiro; Kubushiro, Kaneyuki

    2015-09-01

    To evaluate the efficacy and safety of Kampo therapy based on Goreisan for lower abdominal lymphedema after surgical treatment of endometrial cancer or cervical cancer. Radical surgery, including retroperitoneal lymphadenectomy, was performed for endometrial cancer and cervical cancer. After surgery, Kampo therapy based on Goreisan and integrated physical therapy were provided for patients with lower abdominal lymphedema, especially lymphedema affecting the pubic-inguinal-vulval region. Goreisan (7.5 g/day) was given orally three times a day (tds). If a significant response was not observed, Saireito (9 g/day; 3 g tds) or Gosyajinkigan (7.5 g/day; 2.5 g tds) was administered concomitantly. A total of 21 patients received treatment. The response rate to Goreisan monotherapy was 78%, with 22% being non-responders. Median reduction of abdominal circumference was 2.1cm (95% CI 1.3-2.85). When Goreisan was combined with another Kampo agent, the response rate was 92% and the non-response rate was 8%. The median reduction of the abdominal circumference was 2.85 cm (95% CI: 2.25-3.3). In particular, concomitant Goreisan and Saireito therapy achieved satisfactory results. No severe adverse reactions occurred. Goreisan-based Kampo therapy might be effective and safe for lower abdominal lymphedema after retroperitoneal lymphadenectomy. We will perform a prospective control study in the near future. © 2015 Japan Society of Obstetrics and Gynecology.

  7. Feasibility of adjuvant chemotherapy with S-1 plus carboplatin followed by single-agent maintenance therapy with S-1 for completely resected non-small-cell lung cancer: results of the Setouchi Lung Cancer Group Study 1001.

    Science.gov (United States)

    Okumura, Norihito; Sonobe, Makoto; Okabe, Kazunori; Nakamura, Hiroshige; Kataoka, Masafumi; Yamashita, Motohiro; Nakata, Masao; Kataoka, Kazuhiko; Yamashita, Yoshinori; Soh, Junichi; Yoshioka, Hiroshige; Hotta, Katsuyuki; Matsuo, Keitaro; Sakamoto, Junichi; Toyooka, Shinichi; Date, Hiroshi

    2017-04-01

    This multicenter study evaluated the feasibility of novel adjuvant chemotherapy with S-1 plus carboplatin followed by single-agent, long-term maintenance with S-1 in patients with completely resected stage II-IIIA non-small-cell lung cancer (NSCLC). Patients received four cycles of S-1 (80 mg/m2/day for 2 weeks, followed by 2 weeks rest) plus carboplatin (area under the curve 5, day 1) followed by S-1 (80 mg/m2/day for 2 weeks, followed by a 1-week rest). Patients unable to continue S-1 plus carboplatin because of severe toxicity converted to single-agent S-1 maintenance. The duration of adjuvant chemotherapy was 10 months in both situations. The primary endpoint was feasibility, defined as the proportion of patients who completed four cycles of S-1 plus carboplatin and single-agent S-1 maintenance for 10 months. The treatment completion rate was determined; treatment was considered feasible if the lower 90% confidence interval (CI) was ≥50%. Eighty-nine patients were enrolled, of whom 87 were eligible and assessable. Seventy-eight patients (89.7%) completed four cycles of S-1 plus carboplatin and 55 (63.2%) completed the following S-1 maintenance therapy for a total of 10 months. The treatment completion rate was 63.2% (90% CI, 54.4-71.2%), indicating feasibility. There were no treatment-related deaths. Grade 3/4 toxicities included neutropenia (13.8%), thrombocytopenia (11.5%), and anorexia (4.6%). The 2-year relapse-free survival rate was 59.8%. We concluded that adjuvant chemotherapy with S-1 plus carboplatin followed by single-agent maintenance therapy with S-1 is feasible and tolerable in patients with completely resected NSCLC. UMIN000005041.

  8. Low-Intensity Cognitive Behavioural Therapy-Based Music Group (CBT-Music) for the Treatment of Symptoms of Anxiety and Depression: A Feasibility Study.

    Science.gov (United States)

    Trimmer, Chris; Tyo, Richard; Pikard, Jennifer; McKenna, Claire; Naeem, Farooq

    2017-10-09

    Music has the potential to be an effective and engaging therapeutic intervention in the treatment of mental illness. This research area remains underdeveloped. This paper reports the feasibility of an innovative low-intensity CBT-based music (CBT-Music) group targeted to symptoms of depression and anxiety. A total of 28 participants with symptoms of depression and anxiety who were attending community mental health services were recruited for the study and randomized into TAU (treatment as usual) plus low-intensity CBT-Music (treatment) or to TAU alone (control). The treatment group consisted of a 9-week music group that incorporated various components of CBT material into a musical context. Feasibility was the primary outcome. The secondary outcomes were a reduction in depression, anxiety (Hospital Anxiety and Depression Scale) and disability (WHO Disability Assessment Schedule 2.0) assessed at baseline and 10 weeks. Recruitment proved feasible, retention rates were high, and the participants reported a high level of acceptability. A randomized control study design was successfully implemented as there were no significant differences between treatment and control groups at baseline. Participants in the treatment group showed improvement in disability (p = 0.027). Despite a reduction in depression and anxiety scores, these differences were not statistically significant. A low-intensity CBT-based music group can be successfully administered to clients of community mental health services. There are indications of effectiveness in reducing disability, although there appears to be negligible effect on symptoms of anxiety and depression. This is the first report of a trial of a low-intensity CBT-based music group intervention.

  9. Sault Tribe Wind Energy Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Toni Osterhout; Global Energy Concepts

    2005-07-31

    The Sault Tribe conducted a feasibility study on tribal lands in the Upper Peninsula of Michigan to determine the technical and economic feasibility of both small and large-scale wind power development on tribal lands. The study included a wind resource assessment, transmission system analysis, engineering and regulatory analyzes and assessments.

  10. Computerized Cognitive Behavioral Therapy to Treat Emotional Distress After Stroke: A Feasibility Randomized Controlled Trial

    OpenAIRE

    Simblett, SK; Yates, M; Wagner, AP; Watson, P; Gracey, F; Ring, H; Bateman, Andrew

    2017-01-01

    $\\textbf{Background:}$ Depression and anxiety are common complications following stroke. Symptoms could be treatable with psychological therapy, but there is little research on its efficacy. $\\textbf{Objectives:}$ The aim of this study was to investigate (1) the acceptability and feasibility of computerized cognitive behavioral therapy (cCBT) to treat symptoms of depression and anxiety and (2) a trial design for comparing the efficacy of cCBT compared with an active comparator. $\\te...

  11. Feasibility of using laser ion accelerators in proton therapy

    CERN Document Server

    Bulanov, S V

    2002-01-01

    The feasibility of using the laser plasma as a source of the high-energy ions for the proton radiation therapy is discussed. The proposal is based on the recent inventions of the effective ions acceleration in the experiments and through numerical modeling of the powerful laser radiation interaction with the gaseous and solid state targets. The principal peculiarity of the dependence of the protons energy losses in the tissues (the Bragg peak of losses) facilities the solution of one of the most important problems of the radiation therapy, which consists in realizing the tumor irradiation by sufficiently high and homogeneous dose with simultaneous minimization of the irradiation level, relative to the healthy and neighbouring tissues and organs

  12. Muon Muon Collider: Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Gallardo, J.C.; Palmer, R.B.; /Brookhaven; Tollestrup, A.V.; /Fermilab; Sessler, A.M.; /LBL, Berkeley; Skrinsky, A.N.; /Novosibirsk, IYF; Ankenbrandt, C.; Geer, S.; Griffin, J.; Johnstone, C.; Lebrun, P.; McInturff, A.; Mills, Frederick E.; Mokhov, N.; Moretti, A.; Neuffer, D.; Ng, K.Y.; Noble, R.; Novitski, I.; Popovic, M.; Qian, C.; Van Ginneken, A. /Fermilab /Brookhaven /Wisconsin U., Madison /Tel Aviv U. /Indiana U. /UCLA /LBL, Berkeley /SLAC /Argonne /Sobolev IM, Novosibirsk /UC, Davis /Munich, Tech. U. /Virginia U. /KEK, Tsukuba /DESY /Novosibirsk, IYF /Jefferson Lab /Mississippi U. /SUNY, Stony Brook /MIT /Columbia U. /Fairfield U. /UC, Berkeley

    2012-04-05

    A feasibility study is presented of a 2 + 2 TeV muon collider with a luminosity of L = 10{sup 35} cm{sup -2}s{sup -1}. The resulting design is not optimized for performance, and certainly not for cost; however, it does suffice - we believe - to allow us to make a credible case, that a muon collider is a serious possibility for particle physics and, therefore, worthy of R and D support so that the reality of, and interest in, a muon collider can be better assayed. The goal of this support would be to completely assess the physics potential and to evaluate the cost and development of the necessary technology. The muon collider complex consists of components which first produce copious pions, then capture the pions and the resulting muons from their decay; this is followed by an ionization cooling channel to reduce the longitudinal and transverse emittance of the muon beam. The next stage is to accelerate the muons and, finally, inject them into a collider ring wich has a small beta function at the colliding point. This is the first attempt at a point design and it will require further study and optimization. Experimental work will be needed to verify the validity of diverse crucial elements in the design. Muons because of their large mass compared to an electron, do not produce significant synchrotron radiation. As a result there is negligible beamstrahlung and high energy collisions are not limited by this phenomena. In addition, muons can be accelerated in circular devices which will be considerably smaller than two full-energy linacs as required in an e{sup +} - e{sup -} collider. A hadron collider would require a CM energy 5 to 10 times higher than 4 TeV to have an equivalent energy reach. Since the accelerator size is limited by the strength of bending magnets, the hadron collider for the same physics reach would have to be much larger than the muon collider. In addition, muon collisions should be cleaner than hadron collisions. There are many detailed particle

  13. Evaluation of a novel sputum clearance technique--hydro-acoustic therapy (HAT) in adult patients with cystic fibrosis: a feasibility study.

    Science.gov (United States)

    Jarad, N A; Powell, T; Smith, E

    2010-01-01

    This study was designed to investigate the efficacy, safety and patients' acceptance of a novel system for sputum clearance--Hydro Acoustic Therapy (HAT) in patients with cystic fibrosis (CF). This is a prospective crossover study where 18 patients received 6 sessions of physiotherapy over 6 separate days. These consisted of 2 sessions of either HAT, flutter valve or and sitting in the bath with sounds without vibration (placebo) for 30 minutes each. The efficacy was investigated by measuring the weight of wet and dry sputum after each session and by change in spirometry values. The preference was assessed by a questionnaire completed by patients at the end of the study about their preference of which type of physiotherapy received. The weight of both dry and wet sputum produced was similar in the 3 arms of the study. Spirometry values but not oxygen saturation were reduced after HAT and flutter therapy sessions. HAT therapy was preferred to flutter and placebo in terms of breathlessness, ease of sputum production and relaxation. Of the patients, 70% stated that they would choose HAT as their preferred physiotherapy method compared to 0% for flutter (χ(2) = 20.3, p < 0.0001). There were no procedure-related complications in any of the 3 arms of the study. HAT was found to be safe, well tolerated and favoured by the majority of CF patients. The effect of HAT, however, on sputum production was not superior to flutter or placebo.

  14. Feasibility of a Prototype Web-Based Acceptance and Commitment Therapy Prevention Program for College Students

    Science.gov (United States)

    Levin, Michael E.; Pistorello, Jacqueline; Seeley, John R.; Hayes, Steven C.

    2014-01-01

    Objective: This study examined the feasibility of a prototype Web-based acceptance and commitment therapy (ACT) program for preventing mental health problems among college students. Participants: Undergraduate first-year students ("N" = 76) participated between May and November 2011. Methods: Participants were randomized to ACT or a…

  15. Ecological Feasibility Studies in Restoration Decision Making

    Science.gov (United States)

    Hopfensperger, Kristine N.; Engelhardt, Katharina A. M.; Seagle, Steven W.

    2007-06-01

    The restoration of degraded systems is essential for maintaining the provision of valuable ecosystem services, including the maintenance of aesthetic values. However, restoration projects often fail to reach desired goals for a variety of ecologic, financial, and social reasons. Feasibility studies that evaluate whether a restoration effort should even be attempted can enhance restoration success by highlighting potential pitfalls and gaps in knowledge before the design phase of a restoration. Feasibility studies also can bring stakeholders together before a restoration project is designed to discuss potential disagreements. For these reasons, a feasibility study was conducted to evaluate the efficacy of restoring a tidal freshwater marsh in the Potomac River near Alexandria, Virginia. The study focused on science rather than engineering questions, and thus differed in approach from other feasibility studies that are mostly engineering driven. The authors report the framework they used to conduct a feasibility study to inform other potential restoration projects with similar goals. The seven steps of the framework encompass (1) initiation of a feasibility study, (2) compilation of existing data, (3) collection of current site information, (4) examination of case studies, (5) synthesis of information in a handbook, (6) meeting with selected stakeholders, and (7) evaluation of meeting outcomes. By conducting a feasibility study using the seven-step framework, the authors set the stage for conducting future compliance studies and enhancing the chance of a successful restoration.

  16. Focal therapy with high-intensity focused ultrasound for prostate cancer in the elderly: a feasibility study with 10 years follow-up

    Directory of Open Access Journals (Sweden)

    Amine B. El Fegoun

    2011-04-01

    Full Text Available PURPOSE: To evaluate the long-term efficacy of prostate cancer control and complication rates, in the elderly, after focal therapy with high-intensity focused ultrasound (HIFU. MATERIALS AND METHODS: Between June 1997 and March 2000, patients with localized prostate cancer were included into a focal therapy protocol. Inclusion criteria were: PSA < 10 ng/mL, < 3 positive biopsies with only 1 lobe involved, clinical stage < T2a, Gleason score < 7 (3+4, negative CT scan and bone scan. Hemi-ablation of the prostate was performed with the Ablatherm(R device. Survival, complication rates and urinary continence were evaluated. Control biopsies were performed at 1 year. Treatment failure was defined as a positive biopsy or need for salvage therapy. RESULTS: Twelve patients with a mean age 70 years were included. Median follow-up was 10 years. Control prostate biopsies were negative in 11/12 (91% patients. Overall survival was 83% (10/12 and cancer specific survival was 100% at 10 years. Two patients died from other causes. Recurrence free survival was 90% (95% CI; 0.71-1 at 5 years, and 38% (95% CI; 0.04-0.73 at 10 years. Five patients had salvage therapy with repeat HIFU (n = 1 or hormonal therapy (n = 4 and all salvage patients were alive at 10 years. No patients developed lymph node or bone metastasis. No patients suffered from urinary incontinence. International Prostate Symptom Score was stable at 1 year. Complications included two urinary tract infections and one episode of acute urinary retention. CONCLUSIONS: Hemi-prostate ablation with HIFU can be safely performed in selected elderly patients with adequate long-term cancer control and low complication rates. Results from larger prospective studies using improved imaging techniques and extensive biopsy protocols are awaited.

  17. SU-D-304-04: Pre-Clinical Feasibility Study for Intensity Modulated Grid Proton Therapy (IMgPT) Using a Newly Developed Delivery System

    Energy Technology Data Exchange (ETDEWEB)

    Tsiamas, P; Moskvin, V; Shin, J; Axente, M; Pirlepesov, F; Krasin, M; Merchant, T; Farr, J [St. Jude Children’s Research Hospital, Memphis, TN (United States)

    2015-06-15

    Purpose: The purpose of the current study was to characterize and evaluate intensity-modulated proton grid therapy (IMgPT) using a clinical proton beam. Methods: A TOPAS MC model of a new developmental mode (pre-clinical) of the Hitachi proton therapy system (PROBEAT) was used for simulation and characterization of proton grid therapy. TOPAS simulations of different energy ranges, depths and spot separation distances were performed. LET spectra for various energies and depths were produced with FLUKA MC code for evaluation potential interplay between planning parameters and their effect on the characterization of areas (valley) between spots. IMgPT planning aspects (spot spacing, skin dose, peak-to-valley ratios, beam selection, etc.) were evaluated for different phantom and patient cases. Raysearch software (v4.51) was used to perform the evaluation. Results: Calculated beam peak-to-valley ratios scenarios showed strong energy and depth dependence with ratios to be larger for higher energies and shallower depths. Peak-to-valley ratios for R90 range and for spot spacing of 1cm varied from 30% (E = 221.3 MeV, depth 30.6 cm) to 80% (E = 70.3 MeV, depth 4 cm). LET spectra calculations showed spectral hardening with depth, which might potential increase, spot separation distance and improve peak-to-valley ratios. IMgPT optimization, using constant spot spacing, showed skin dose reduction between peak regions of dose due to the irradiation of less skin. Single beam for bulky shallower tumors might be a potential candidate for proton grid therapy. Conclusions: Proton grid therapy using a clinical beam is a promising technique that reduces skin dose between peak regions of dose and may be suitable for the treatment of shallow tumors. IMgPT may be considered for use when bystander effects in off peak regions would be appropriate.

  18. Feasibility Study on HYSOL CSP

    DEFF Research Database (Denmark)

    Nielsen, Lars Henrik; Skytte, Klaus; Pérez, Cristian Hernán Cabrera

    2016-01-01

    Concentrating Solar Power (CSP) plants utilize thermal conversion of direct solar irradiation. A trough or tower configuration focuses solar radiation and heats up oil or molten salt that subsequently in high temperature heat exchangers generate steam for power generation. High temperature molten...... salt can be stored and the stored heat can thus increase the load factor and the usability for a CSP plant, e.g. to cover evening peak demand. In the HYSOL concept (HYbrid SOLar) such configuration is extended further to include a gas turbine fuelled by upgraded biogas or natural gas. The optimised...... integrated HYSOL concept, therefore, becomes a fully dispatchable (offering firm power) and fully renewable energy source (RES) based power supply alternative, offering CO2-free electricity in regions with sufficient solar resources. The economic feasibility of HYSOL configurations is addressed in this paper...

  19. Cognitive behavioral therapy in breast cancer patients--a feasibility study of an 8 week intervention for tumor associated fatigue treatment.

    Science.gov (United States)

    Eichler, Christian; Pia, Multhaupt; Sibylle, Multhaupt; Sauerwald, Axel; Friedrich, Wolff; Warm, Mathias

    2015-01-01

    Tumor associated fatigue (TAF) or cancer related fatigue (CRF) is not a new concept. Nonetheless, no real headway has been made in the quantitative analysis of its successful treatment via cognitive behavioral therapy. Since 20 to 30% of all breast cancer patients suffer from anxiety and/or depression within the first year of their diagnosis, this issue needs to be addressed and a standard treatment protocol has to be developed. This study focused on developing a simple, reproducible and short (8 weeks) protocol for the cognitive behavioral therapy support of tumor associated fatigue patients. Between the year 2011 and 2012, 23 breast cancer patients fulfilled the diagnosis TAF requirements and were introduced into this study. Our method focused on a psycho-oncological support group using a predetermined, highly structured and reproducible, cognitive behavioral therapy treatment manual. Eight weekly, 90 minute sessions were conducted and patients were evaluated before and after this eight session block. Tumor fatigue specific questionnaires such as the multidimensional fatigue inventory (MFI) as well as the hospital anxiety and depression scale (HADS) were used in order to quantitatively evaluate patient TAF. Of the 23 patients enrolled in the study, only 7 patients fulfilled the TAF diagnostic criteria after the psycho-oncological group treatment. This represents a 70% reduction in diagnosable tumor associated fatigue. The HADS analysis showed a 33% reduction in patient anxiety as well as a 57% reduction in patient depression levels. The MFI scores showed a significant reduction in 4 of the 5 evaluate categories. With the exception of the "mental fatigue" MFI category all results were statistically significant. This study showed that a highly structured, cognitive behavioral therapy group intervention will produce significant improvements in breast cancer patient tumor associated fatigue levels after only 8 weeks.

  20. Feasibility and acceptability of group music therapy vs wait-list control for treatment of patients with long-term depression (the SYNCHRONY trial): study protocol for a randomised controlled trial.

    Science.gov (United States)

    Carr, Catherine Elizabeth; O'Kelly, Julian; Sandford, Stephen; Priebe, Stefan

    2017-03-29

    Depression is of significant global concern. Despite a range of effective treatment options it is estimated that around one in five diagnosed with an acute depressive episode continue to experience enduring symptoms for more than 2 years. There is evidence for effectiveness of individual music therapy for depression. However, no studies have as yet looked at a group intervention within an NHS context. This study aims to assess the feasibility of conducting a randomised controlled trial of group music therapy for patients with long-term depression (symptom durations of 1 year or longer) within the community. This is a single-centre randomised controlled feasibility trial of group music therapy versus wait-list control with a nested process evaluation. Thirty participants will be randomised with unbalanced allocation (20 to receive the intervention immediately, 10 as wait-list controls). Group music therapy will be offered three times per week in a community centre with a focus on songwriting. Data will be collected post-intervention, 3 and 6 months after the intervention finishes. We will examine the feasibility of recruitment processes including identifying the number of eligible participants, participation and retention rates and the intervention in terms of testing components, measuring adherence and estimation of the likely intervention effect. A nested process evaluation will consist of treatment fidelity analysis, exploratory analysis of process measures and end-of-participation interviews with participants and referring staff. Whilst group music therapy is an option in some community mental health settings, this will be the first study to examine group music therapy for this particular patient group. We will assess symptoms of depression, acceptability of the intervention and quality of life. We anticipate potential challenges in the recruitment and retention of participants. It is unclear whether offering the intervention three times per week will be

  1. Feasibility of a clinical trial of vision therapy for treatment of amblyopia.

    Science.gov (United States)

    Lyon, Don W; Hopkins, Kristine; Chu, Raymond H; Tamkins, Susanna M; Cotter, Susan A; Melia, B Michele; Holmes, Jonathan M; Repka, Michael X; Wheeler, David T; Sala, Nicholas A; Dumas, Janette; Silbert, David I

    2013-05-01

    We conducted a pilot randomized clinical trial of office-based active vision therapy for the treatment of childhood amblyopia to determine the feasibility of conducting a full-scale randomized clinical trial. A training and certification program and manual of procedures were developed to certify therapists to administer a standardized vision therapy program in ophthalmology and optometry offices consisting of weekly visits for 16 weeks. Nineteen children, aged 7 to less than 13 years, with amblyopia (20/40-20/100) were randomly assigned to receive either 2 hours of daily patching with active vision therapy or 2 hours of daily patching with placebo vision therapy. Therapists in diverse practice settings were successfully trained and certified to perform standardized vision therapy in strict adherence with protocol. Subjects completed 85% of required weekly in-office vision therapy visits. Eligibility criteria based on age, visual acuity, and stereoacuity, designed to identify children able to complete a standardized vision therapy program and judged likely to benefit from this treatment, led to a high proportion of screened subjects being judged ineligible, resulting in insufficient recruitment. There were difficulties in retrieving adherence data for the computerized home therapy procedures. This study demonstrated that a 16-week treatment trial of vision therapy was feasible with respect to maintaining protocol adherence; however, recruitment under the proposed eligibility criteria, necessitated by the standardized approach to vision therapy, was not successful. A randomized clinical trial of in-office vision therapy for the treatment of amblyopia would require broadening of the eligibility criteria and improved methods to gather objective data regarding the home therapy. A more flexible approach that customizes vision therapy based on subject age, visual acuity, and stereopsis might be required to allow enrollment of a broader group of subjects.

  2. Impact of music therapy interventions (listening, composition, Orff-based) on the physiological and psychosocial behaviors of hospitalized children: a feasibility study.

    Science.gov (United States)

    Colwell, Cynthia M; Edwards, Robin; Hernandez, Emily; Brees, Kristine

    2013-01-01

    The purpose of this study was to compare three music therapy strategies (music listening, music composition, and Orff-based active engagement) on physiological (heart rate, blood pressure, oxygen saturation, and pain) and psychosocial (anxiety) behaviors of hospitalized children (N=32, 17 females,15 males, ranging in age from 6 to 17). This study was designed and facilitated cooperatively by pediatric nurses and music therapists. Results indicated no clinically significant changes in heart rate, blood pressure, or oxygen saturation (p>.05). Pain and anxiety both decreased significantly (p=.01) but not differentiated among conditions. Videotape analysis determined level of engagement in coping-related behaviors. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Inpatient Massage Therapy Versus Music Therapy Versus Usual Care: A Mixed-methods Feasibility Randomized Controlled Trial.

    Science.gov (United States)

    Roseen, Eric J; Cornelio-Flores, Oscar; Lemaster, Chelsey; Hernandez, Maria; Fong, Calvin; Resnick, Kirsten; Wardle, Jon; Hanser, Suzanne; Saper, Robert

    2017-01-01

    Little is known about the feasibility of providing massage or music therapy to medical inpatients at urban safety-net hospitals or the impact these treatments may have on patient experience. To determine the feasibility of providing massage and music therapy to medical inpatients and to assess the impact of these interventions on patient experience. Single-center 3-arm feasibility randomized controlled trial. Urban academic safety-net hospital. Adult inpatients on the Family Medicine ward. Massage therapy consisted of a standardized protocol adapted from a previous perioperative study. Music therapy involved a preference assessment, personalized compact disc, music-facilitated coping, singing/playing music, and/or songwriting. Credentialed therapists provided the interventions. Patient experience was measured with the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) within 7 days of discharge. We compared the proportion of patients in each study arm reporting "top box" scores for the following a priori HCAHPS domains: pain management, recommendation of hospital, and overall hospital rating. Responses to additional open-ended postdischarge questions were transcribed, coded independently, and analyzed for common themes. From July to December 2014, 90 medical inpatients were enrolled; postdischarge data were collected on 68 (76%) medical inpatients. Participants were 70% females, 43% non-Hispanic black, and 23% Hispanic. No differences between groups were observed on HCAHPS. The qualitative analysis found that massage and music therapy were associated with improved overall hospital experience, pain management, and connectedness to the massage or music therapist. Providing music and massage therapy in an urban safety-net inpatient setting was feasible. There was no quantitative impact on HCAHPS. Qualitative findings suggest benefits related to an improved hospital experience, pain management, and connectedness to the massage or music therapist.

  4. Inpatient Massage Therapy Versus Music Therapy Versus Usual Care: A Mixed-methods Feasibility Randomized Controlled Trial

    Science.gov (United States)

    Cornelio-Flores, Oscar; Lemaster, Chelsey; Hernandez, Maria; Fong, Calvin; Resnick, Kirsten; Wardle, Jon; Hanser, Suzanne; Saper, Robert

    2017-01-01

    Background Little is known about the feasibility of providing massage or music therapy to medical inpatients at urban safety-net hospitals or the impact these treatments may have on patient experience. Objective To determine the feasibility of providing massage and music therapy to medical inpatients and to assess the impact of these interventions on patient experience. Design Single-center 3-arm feasibility randomized controlled trial. Setting Urban academic safety-net hospital. Patients Adult inpatients on the Family Medicine ward. Interventions Massage therapy consisted of a standardized protocol adapted from a previous perioperative study. Music therapy involved a preference assessment, personalized compact disc, music-facilitated coping, singing/playing music, and/or songwriting. Credentialed therapists provided the interventions. Measurements Patient experience was measured with the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) within 7 days of discharge. We compared the proportion of patients in each study arm reporting “top box” scores for the following a priori HCAHPS domains: pain management, recommendation of hospital, and overall hospital rating. Responses to additional open-ended postdischarge questions were transcribed, coded independently, and analyzed for common themes. Results From July to December 2014, 90 medical inpatients were enrolled; postdischarge data were collected on 68 (76%) medical inpatients. Participants were 70% females, 43% non-Hispanic black, and 23% Hispanic. No differences between groups were observed on HCAHPS. The qualitative analysis found that massage and music therapy were associated with improved overall hospital experience, pain management, and connectedness to the massage or music therapist. Conclusions Providing music and massage therapy in an urban safety-net inpatient setting was feasible. There was no quantitative impact on HCAHPS. Qualitative findings suggest benefits related to an

  5. Feasibility of a Trial on Improvisational Music Therapy for Children with Autism Spectrum Disorder.

    Science.gov (United States)

    Geretsegger, Monika; Holck, Ulla; Bieleninik, Łucja; Gold, Christian

    2016-01-01

    To conduct generalizable, rigorously designed, adequately powered trials investigating music therapy and other complex interventions, it is essential that study procedures are feasible and acceptable for participants. To date, only limited evidence on feasibility of trial designs and strategies to facilitate study implementation is available in the music therapy literature. Using data from a subsample of a multi-center RCT on improvisational music therapy (IMT) for autism spectrum disorder (ASD), this study aims to evaluate feasibility of study procedures, evaluate safety, document concomitant treatment, and report consistency of individuals' trends over time in chosen outcome measures. Children with ASD aged between 4 years, 0 months, and 6 years, 11 months, were randomly assigned to one of three conditions: one (low intensity) vs. three weekly IMT sessions (high intensity) for five months vs. standard care. Feasibility was evaluated by examining recruitment, implementation of study conditions, assessment procedures, blinding, and retention; we also evaluated safety, concomitant treatment, and consistency of changes in standardized scales completed by blinded assessors and parents before and 5 months after randomization. Within this subsample (n = 15), recruitment rates, session attendance in the high-intensity condition, and consistency between outcome measures were lower than expected. Session attendance in the low-intensity and control conditions, treatment fidelity, measurement completion, blinding, retention, and safety met a priori thresholds for feasibility. By discussing strategies to improve recruitment and to minimize potential burden on study participants, referrers, and researchers, this study helps build knowledge about designing and implementing trials successfully. © the American Music Therapy Association 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. SU-F-T-662: Feasibility Study of Fe3O4/TaOx Nano Particles as a Radiosensitizer for Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, S [Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University (Korea, Republic of); Lee, N [School of Advanced Materials Engineering College of Engineering, Kookmin Uiniversity (Japan); Shin, S; Choi, C; Han, Y; Park, H; Choi, D; Lim, D [Samsung Medical Center, Sungkyunkwan University School of Medicine radiation oncology (Korea, Republic of)

    2016-06-15

    Purpose: To investigate the feasibility of using multifunctional Fe{sub 3}O{sub 4}/TaOx(core / shell) nano particles developed for CT and MRI contrast agent as dose enhancing radiosensitizers. Methods: Firstly, to verify the imaging detectability of Fe{sub 3}O{sub 4}/TaOx nano particles, in-vivo tests were conducted. Approximately 600 mg/kg of 19 nm diameter Fe{sub 3}O{sub 4}/TaOx nano particles dispersed in phosphate buffered saline(PBS) were injected to ten nude Balb/c mice through the tail vein. Difference between pre- and post-injection images was analyzed by computing the pixel histogram and correlation coefficient factor using MATLAB in the user defined ROI. Secondly, to quantify the potential therapeutic enhancement with nano materials, DER (Dose Enhancement Ratio) and number of SER (Secondary Electron Ratio) were computed using TOPAS(ver.2.0 P-03) MC simulation. Results: In CT, MRI imaging, the aorta, the blood vessel, and the liver were clearly visualized after intravenous injection of Fe{sub 3}O{sub 4}/TaOx nano particles. There was large different between pre and post-injection images of Histogram data and Coefficients of correlation factor in CT and MR are 0.006, 0.060, respectively. When 70 MeV protons were irradiated for a Gold, Tantalum, TaOx, Fe{sub 3}O{sub 4}/TaOx, Fe{sub 3}O{sub 4} nano particle, DER was 2.59, 2.41, 1.68, 1.54 and 1.36 respectively. Similarly, SER increment was 2.31, 2.15, 1.56, 1.46, and 1.27 for Gold, Tantalum, TaOx, Fe{sub 3}O{sub 4}/TaOx, Fe{sub 3}O{sub 4} nano particle, respectively. Conclusion: Fe{sub 3}O{sub 4}/TaOx nano particles have potential as a multifunctional agent which enhances the accuracy in cancer detection through visualization of developed tumor lesion and increases the therapeutic effect in proton therapy. The dose enhancement with Fe{sub 3}O{sub 4}/TaOx was estimated as half of the Gold. However, tumor targeting such as combined with magnetic field may overcome the low DER. This research was supported by the

  7. Three Affliated Tribes Renewable Energy Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Belvin Pete; Kent Good; Krista Gordon; Ed McCarthy,

    2006-05-26

    The Three Affliated Tribes on the Fort Berthold Reservation studied the feasibility of a commercial wind facility on land selected and owned by the Tribes and examined the potential for the development of renewable energy resources on Tribal Lands.

  8. 25 CFR 41.7 - Feasibility studies.

    Science.gov (United States)

    2010-04-01

    ... right to a formal review of the feasibility study, including a hearing upon reasonable notice within..., linguistics, or cultural differences; (4) Isolation; (5) Presence of alternate education sources; (6) Proposed...

  9. White Earth Biomass/Biogas Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Triplett, Michael

    2015-03-12

    The White Earth Nation examined the feasibility of cost savings and fossil energy reduction through the installation of biogas/biomass boiler at the tribal casino. The study rejected biogas options due to availability and site constraints, but found a favorable environment for technical and financial feasibility of installing a 5 MMBtu hot water boiler system to offset 60-70 percent of current fuel oil and propane usage.

  10. Florida Panther Reintroduction Feasibility Study

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Summary and final report of a Florida Fish and Wildlife Conservation Commission study to evalaute initial stocking of mountain lion populations in northern...

  11. Computerised mirror therapy with Augmented Reflection Technology for early stroke rehabilitation: clinical feasibility and integration as an adjunct therapy.

    Science.gov (United States)

    Hoermann, Simon; Ferreira Dos Santos, Luara; Morkisch, Nadine; Jettkowski, Katrin; Sillis, Moran; Devan, Hemakumar; Kanagasabai, Parimala S; Schmidt, Henning; Krüger, Jörg; Dohle, Christian; Regenbrecht, Holger; Hale, Leigh; Cutfield, Nicholas J

    2017-07-01

    New rehabilitation strategies for post-stroke upper limb rehabilitation employing visual stimulation show promising results, however, cost-efficient and clinically feasible ways to provide these interventions are still lacking. An integral step is to translate recent technological advances, such as in virtual and augmented reality, into therapeutic practice to improve outcomes for patients. This requires research on the adaptation of the technology for clinical use as well as on the appropriate guidelines and protocols for sustainable integration into therapeutic routines. Here, we present and evaluate a novel and affordable augmented reality system (Augmented Reflection Technology, ART) in combination with a validated mirror therapy protocol for upper limb rehabilitation after stroke. We evaluated components of the therapeutic intervention, from the patients' and the therapists' points of view in a clinical feasibility study at a rehabilitation centre. We also assessed the integration of ART as an adjunct therapy for the clinical rehabilitation of subacute patients at two different hospitals. The results showed that the combination and application of the Berlin Protocol for Mirror Therapy together with ART was feasible for clinical use. This combination was integrated into the therapeutic plan of subacute stroke patients at the two clinical locations where the second part of this research was conducted. Our findings pave the way for using technology to provide mirror therapy in clinical settings and show potential for the more effective use of inpatient time and enhanced recoveries for patients. Implications for Rehabilitation Computerised Mirror Therapy is feasible for clinical use Augmented Reflection Technology can be integrated as an adjunctive therapeutic intervention for subacute stroke patients in an inpatient setting Virtual Rehabilitation devices such as Augmented Reflection Technology have considerable potential to enhance stroke rehabilitation.

  12. [Pneumology and Sports: An Outpatient Endurance Training with Sports Medical Guidance as an Effective Non-pharmacological Therapy in Pneumology - a Feasibility Study].

    Science.gov (United States)

    Ammenwerth, W; Crolow, C; Wurps, H; Schultz, Th; Krüll, M; Ukas, K; Schönfeld, N; Blum, T G; Bauer, T T

    2016-05-01

    In the process of medical rehabilitation muscular endurance training is the main focus. Unfortunately, outpatient rehabilitation opportunities are limited and specialized pulmonary exercise groups ("lung sport groups") rarely available. Therefore we developed an outpatient endurance sports program for patients with respiratory diseases and evaluated its effectiveness. In this feasibility study 31 patients (50 ± 15 years) with diverse respiratory diseases were included. By professional functional exercise testing (incl. CPET and lactate measurement according to the standards of DGP and DGSP) the patients optimal training zone was determined and an individualized 12 week lasting aerobic endurance training with ≥ 3 sessions of 20 - 60 min/week realized. After completion of the exercise training program a significant improvement in dyspnoea (Borg-Scale: 65.7 ± 12.2 vs. 62.2 ± 12.6, p = 0.013), body constitution (BMI: 25.7 ± 3.3 vs. 24.3 ± 3.2 kg/m(2), p = 0.018; portion of body fat: 24.8 ± 5.8 vs. 23.8 ± 6.4 %, p = 0.043) as well as physical capacity (VO2 at 4 mmol/l Laktat: 24.2 ± 6.9 vs. 26.5 ± 7.6 ml/min/kg, p sports medical treatment in patients with diverse pulmonary diseases. © Georg Thieme Verlag KG Stuttgart · New York.

  13. Woodbridge Research Facility Remedial Investigation/Feasibility Study; Focused Feasibility Study for Operable Unit One

    National Research Council Canada - National Science Library

    Thompson, Patricia

    1997-01-01

    ...). A Focused Feasibility Study,, has been conducted to identify and screen remedial alternatives for OUl, to address, contaminated groundwater, surface soil, subsurface soil, and sediment detected...

  14. Feasibility of daylight-mediated photodynamic therapy for actinic keratosis throughout the year in Central and South America: a meteorological study.

    Science.gov (United States)

    Grinblat, Beni; Galimberti, Gaston; Pantoja, Gonzalo; Sanclemente, Gloria; Lopez, Miguel; Alcala, Daniel; Torezan, Luís; Kerob, Delphine; Pascual, Thierry; Chouela, Edgardo

    2016-09-01

    Daylight-mediated photodynamic therapy (DL-PDT) is an efficacious treatment option for thin actinic keratosis (AK) that offers advantages over conventional PDT in terms of tolerability, treatment duration, and cost. A clinical study conducted in Australia determined the mean irradiance during a 2-hour exposure to be 305.8 W/m(2) (range: 40-585 W/m(2) ). The protoporphyrin IX light dose is influenced by latitude, weather conditions, and time of year. A recent study of meteorological data concluded that DL-PDT can be performed effectively throughout the year in Australia. Based on the same hypothesis and applying the same methodology, the present study investigated the suitability of daylight to perform DL-PDT in Central and South America. Solar radiation and weather data were gathered and analyzed to assess daylight irradiance (light intensity) throughout a full year across 32 geographical locations in Central and South America. The minimum average daily solar irradiance reported was above 305.8 W/m(2) in all locations investigated throughout the year. Annual averages of daily irradiance ranged from 578 W/m(2) in Chihuahua, Mexico, to 321 W/m(2) in Puerto Montt, Chile. Daylight-mediated PDT for AK can be performed effectively throughout the year in Central and South America given that weather conditions permit a comfortable 2-hour direct exposure to daylight. © 2016 The Authors. International Journal of Dermatology published by John Wiley & Sons Ltd on behalf of International Society of Dermatology.

  15. Viscosity Control Experiment Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Heidi E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bradley, Paul Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-01-31

    Turbulent mix has been invoked to explain many results in Inertial Confinement Fusion (ICF) and High Energy Density (HED) physics, such as reduced yield in capsule implosions. Many ICF capsule implosions exhibit interfacial instabilities seeded by the drive shock, but it is not clear that fully developed turbulence results from this. Many simulations use turbulent mix models to help match simulation results to data, but this is not appropriate if turbulence is not present. It would be useful to have an experiment where turbulent mixing could be turned on or off by design. The use of high-Z dopants to modify viscosity and the resulting influence on turbulence is considered here. A complicating factor is that the plasma in some implosions can become strongly coupled, which makes the Spitzer expression for viscosity invalid. We first consider equations that cover a broad parameter space in temperature and density to address regimes for various experimental applications. Next, a previous shock-tube and other ICF experiments that investigate viscosity or use doping to examine the effects on yield are reviewed. How viscosity and dopants play a role in capsule yield depends on the region and process under consideration. Experiments and simulations have been performed to study the effects of viscosity on both the hot spot and the fuel/ablator mix. Increases in yield have been seen for some designs, but not all. We then discuss the effect of adding krypton dopant to the gas region of a typical OMEGA and a 2-shock NIF implosion to determine approximately the effect of adding dopant on the computed Reynolds number. Recommendations for a path forward for possible experiments using high-Z dopants to affect viscosity and turbulence are made.

  16. Feasibility Study of a Randomized Controlled Trial of a Telephone-Delivered Problem Solving-Occupational Therapy Intervention to Reduce Participation Restrictions in Rural Breast Cancer Survivors Undergoing Chemotherapy

    Science.gov (United States)

    Hegel, Mark T.; Lyons, Kathleen D.; Hull, Jay G.; Kaufman, Peter; Urquhart, Laura; Li, Zhongze; Ahles, Tim A.

    2010-01-01

    Objective Breast cancer patients receiving adjuvant chemotherapy often experience functional effects of treatment that limit participation in life activities. The purpose of this study was to examine the feasibility of conducting a randomized controlled trial (RCT) of a novel intervention for these restrictions, determine acceptability of the intervention, and preliminarily assess its effects. Methods A pilot RCT of a telephone-delivered Problem Solving and Occupational Therapy intervention (PST-OT) to improve participation restrictions in rural breast cancer patients undergoing chemotherapy. Thirty-one participants with Stages 1-3 breast cancer were randomized to 6 weekly sessions of PST-OT (n=15) and Usual Care (n=16). The primary study outcome was the feasibility of conducting the trial. Secondary outcomes were functional, quality of life and emotional status as assessed at baseline, 6 weeks and 12 weeks. Results Of 46 patients referred 31 were enrolled (67% recruitment rate), of which 6 participants withdrew (81% retention rate). Twenty-four participants completed all study-related assessments (77%). Ninety-two percent of PST-OT participants were highly satisfied with the intervention, and 92% reported PST-OT to be helpful/very helpful for overcoming participation restrictions. Ninety-seven percent of planned PST-OT treatment sessions were completed. Completion rates for PST-OT homework tasks were high. Measures of functioning, quality of life and emotional state favored the PST-OT condition. Conclusion This pilot study suggests that an RCT of the PST-OT intervention is feasible to conduct with rural breast cancer patients undergoing adjuvant chemotherapy and that PST-OT may have positive effects on function, quality of life, and emotional state. PMID:20821373

  17. Feasibility study of a randomized controlled trial of a telephone-delivered problem-solving-occupational therapy intervention to reduce participation restrictions in rural breast cancer survivors undergoing chemotherapy.

    Science.gov (United States)

    Hegel, Mark T; Lyons, Kathleen D; Hull, Jay G; Kaufman, Peter; Urquhart, Laura; Li, Zhongze; Ahles, Tim A

    2011-10-01

    Breast cancer patients receiving adjuvant chemotherapy often experience functional effects of treatment that limit participation in life activities. The purpose of this study was to examine the feasibility of conducting a randomized controlled trial (RCT) of a novel intervention for these restrictions, determine acceptability of the intervention, and preliminarily assess its effects. A pilot RCT of a telephone-delivered Problem-solving and Occupational Therapy intervention (PST-OT) to improve participation restrictions in rural breast cancer patients undergoing chemotherapy. Thirty-one participants with Stages 1-3 breast cancer were randomized to 6 weekly sessions of PST-OT (n = 15) and usual care (n = 16). The primary study outcome was the feasibility of conducting the trial. Secondary outcomes were functional, quality of life and emotional status as assessed at baseline, 6 and 12 weeks. Of 46 patients referred 31 were enrolled (67% recruitment rate), of which 6 participants withdrew (81% retention rate). Twenty-four participants completed all study-related assessments (77%). Ninety-two percent of PST-OT participants were highly satisfied with the intervention, and 92% reported PST-OT to be helpful/very helpful for overcoming participation restrictions. Ninety-seven percent of planned PST-OT treatment sessions were completed. Completion rates for PST-OT homework tasks were high. Measures of functioning, quality of life, and emotional state favored the PST-OT condition. This pilot study suggests that an RCT of the PST-OT intervention is feasible to conduct with rural breast cancer patients undergoing adjuvant chemotherapy and that PST-OT may have positive effects on function, quality of life, and emotional state. 2010 John Wiley & Sons, Ltd.

  18. Fully Automated Simultaneous Integrated Boosted-Intensity Modulated Radiation Therapy Treatment Planning Is Feasible for Head-and-Neck Cancer: A Prospective Clinical Study

    Energy Technology Data Exchange (ETDEWEB)

    Wu Binbin, E-mail: binbin.wu@gunet.georgetown.edu [Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, Baltimore, Maryland (United States); Department of Radiation Medicine, Georgetown University Hospital, Washington, DC (United States); McNutt, Todd [Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, Baltimore, Maryland (United States); Zahurak, Marianna [Department of Oncology Biostatistics, Johns Hopkins University, Baltimore, Maryland (United States); Simari, Patricio [Autodesk Research, Toronto, ON (Canada); Pang, Dalong [Department of Radiation Medicine, Georgetown University Hospital, Washington, DC (United States); Taylor, Russell [Department of Computer Science, Johns Hopkins University, Baltimore, Maryland (United States); Sanguineti, Giuseppe [Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, Baltimore, Maryland (United States)

    2012-12-01

    Purpose: To prospectively determine whether overlap volume histogram (OVH)-driven, automated simultaneous integrated boosted (SIB)-intensity-modulated radiation therapy (IMRT) treatment planning for head-and-neck cancer can be implemented in clinics. Methods and Materials: A prospective study was designed to compare fully automated plans (APs) created by an OVH-driven, automated planning application with clinical plans (CPs) created by dosimetrists in a 3-dose-level (70 Gy, 63 Gy, and 58.1 Gy), head-and-neck SIB-IMRT planning. Because primary organ sparing (cord, brain, brainstem, mandible, and optic nerve/chiasm) always received the highest priority in clinical planning, the study aimed to show the noninferiority of APs with respect to PTV coverage and secondary organ sparing (parotid, brachial plexus, esophagus, larynx, inner ear, and oral mucosa). The sample size was determined a priori by a superiority hypothesis test that had 85% power to detect a 4% dose decrease in secondary organ sparing with a 2-sided alpha level of 0.05. A generalized estimating equation (GEE) regression model was used for statistical comparison. Results: Forty consecutive patients were accrued from July to December 2010. GEE analysis indicated that in APs, overall average dose to the secondary organs was reduced by 1.16 (95% CI = 0.09-2.33) with P=.04, overall average PTV coverage was increased by 0.26% (95% CI = 0.06-0.47) with P=.02 and overall average dose to the primary organs was reduced by 1.14 Gy (95% CI = 0.45-1.8) with P=.004. A physician determined that all APs could be delivered to patients, and APs were clinically superior in 27 of 40 cases. Conclusions: The application can be implemented in clinics as a fast, reliable, and consistent way of generating plans that need only minor adjustments to meet specific clinical needs.

  19. Accelerating volumetric cine MRI (VC-MRI) using undersampling for real-time 3D target localization/tracking in radiation therapy: a feasibility study.

    Science.gov (United States)

    Harris, Wendy; Yin, Fang-Fang; Wang, Chunhao; Zhang, You; Cai, Jing; Ren, Lei

    2017-12-14

    SP  =  8% (32 spokes). It is feasible to estimate VC-MRI from a single undersampled on-board 2D cine MRI. Phantom and patient studies showed that the temporal resolution of VC-MRI can potentially be improved by 5-10 times using a 2D cine image acquired with 10-20% k-space sampling.

  20. Accelerating volumetric cine MRI (VC-MRI) using undersampling for real-time 3D target localization/tracking in radiation therapy: a feasibility study

    Science.gov (United States)

    Harris, Wendy; Yin, Fang-Fang; Wang, Chunhao; Zhang, You; Cai, Jing; Ren, Lei

    2018-01-01

    , for radial-based sampling with SP  =  8% (32 spokes). Conclusions. It is feasible to estimate VC-MRI from a single undersampled on-board 2D cine MRI. Phantom and patient studies showed that the temporal resolution of VC-MRI can potentially be improved by 5–10 times using a 2D cine image acquired with 10–20% k-space sampling.

  1. Feasibility and acceptability of mobile phone short message service as a support for patients receiving antiretroviral therapy in rural Uganda: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Jiho Kim

    2015-12-01

    Full Text Available Introduction: Mobile phone technologies have been promoted to improve adherence to antiretroviral therapy (ART. We studied the receptiveness of patients in a rural Ugandan setting to the use of short messaging service (SMS communication for such purposes. Methods: We performed a cross-sectional analysis measuring mobile phone ownership and literacy amongst patients of The AIDS Support Organisation (TASO in Jinja, Uganda. We performed bivariate and multivariate logistic regression analyses to examine associations between explanatory variables and a composite outcome of being literate and having a mobile phone. Results: From June 2012 to August 2013, we enrolled 895 participants, of whom 684 (76% were female. The median age was 44 years. A total of 576 (63% were both literate and mobile phone users. Of these, 91% (527/ 576 responded favourably to the potential use of SMS for health communication, while only 38.9% (124/319 of others were favourable to the idea (p<0.001. A lower proportion of literate mobile phone users reported optimal adherence to ART (86.4% vs. 90.6%; p=0.007. Male participants (AOR=2.81; 95% CI 1.83–4.30, sub-optimal adherence (AOR=1.76; 95% CI 1.12–2.77, those with waged or salaried employment (AOR=2.35; 95% CI 1.23–4.49, crafts/trade work (AOR=2.38; 95% CI 1.11–5.12, or involved in petty trade (AOR=1.85; 95% CI 1.09–3.13 (in comparison to those with no income were more likely to report mobile phone ownership and literacy. Conclusions: In a rural Ugandan setting, we found that over 60% of patients could potentially benefit from a mobile phone-based ART adherence support. However, support for such an intervention was lower for other patients.

  2. Feasibility and acceptability of mobile phone short message service as a support for patients receiving antiretroviral therapy in rural Uganda: a cross-sectional study.

    Science.gov (United States)

    Kim, Jiho; Zhang, Wendy; Nyonyitono, Maureen; Lourenco, Lillian; Nanfuka, Mastula; Okoboi, Stephen; Birungi, Josephine; Lester, Richard T; Kaleebu, Pontiano; Munderi, Paula; Moore, David M

    2015-01-01

    Mobile phone technologies have been promoted to improve adherence to antiretroviral therapy (ART). We studied the receptiveness of patients in a rural Ugandan setting to the use of short messaging service (SMS) communication for such purposes. We performed a cross-sectional analysis measuring mobile phone ownership and literacy amongst patients of The AIDS Support Organisation (TASO) in Jinja, Uganda. We performed bivariate and multivariate logistic regression analyses to examine associations between explanatory variables and a composite outcome of being literate and having a mobile phone. From June 2012 to August 2013, we enrolled 895 participants, of whom 684 (76%) were female. The median age was 44 years. A total of 576 (63%) were both literate and mobile phone users. Of these, 91% (527/ 576) responded favourably to the potential use of SMS for health communication, while only 38.9% (124/319) of others were favourable to the idea (pmobile phone users reported optimal adherence to ART (86.4% vs. 90.6%; p=0.007). Male participants (AOR=2.81; 95% CI 1.83-4.30), sub-optimal adherence (AOR=1.76; 95% CI 1.12-2.77), those with waged or salaried employment (AOR=2.35; 95% CI 1.23-4.49), crafts/trade work (AOR=2.38; 95% CI 1.11-5.12), or involved in petty trade (AOR=1.85; 95% CI 1.09-3.13) (in comparison to those with no income) were more likely to report mobile phone ownership and literacy. In a rural Ugandan setting, we found that over 60% of patients could potentially benefit from a mobile phone-based ART adherence support. However, support for such an intervention was lower for other patients.

  3. Protocol for a feasibility study of a self-help cognitive behavioural therapy resource for the reduction of dental anxiety in young people.

    Science.gov (United States)

    Marshman, Zoe; Morgan, Annie; Porritt, Jenny; Gupta, Ekta; Baker, Sarah; Creswell, Cathy; Newton, Tim; Stevens, Katherine; Williams, Christopher; Prasad, Suneeta; Kirby, Jennifer; Rodd, Helen

    2016-01-01

    Childhood dental anxiety is very common, with 10-20 % of children and young people reporting high levels of dental anxiety. It is distressing and has a negative impact on the quality of life of young people and their parents as well as being associated with poor oral health. Affected individuals may develop a lifelong reliance on general anaesthetic or sedation for necessary dental treatment thus requiring the support of specialist dental services. Children and young people with dental anxiety therefore require additional clinical time and can be costly to treat in the long term. The reduction of dental anxiety through the use of effective psychological techniques is, therefore, of high importance. However, there is a lack of high-quality research investigating the impact of cognitive behavioural therapy (CBT) approaches when applied to young people's dental anxiety. The first part of the study will develop a profile of dentally anxious young people using a prospective questionnaire sent to a consecutive sample of 100 young people referred to the Paediatric Dentistry Department, Charles Clifford Dental Hospital, in Sheffield. The second part will involve interviewing a purposive sample of 15-20 dental team members on their perceptions of a CBT self-help resource for dental anxiety, their opinions on whether they might use such a resource with patients, and their willingness to recruit participants to a future randomised controlled trial (RCT) to evaluate the resource. The third part of the study will investigate the most appropriate outcome measures to include in a trial, the acceptability of the resource, and retention and completion rates of treatment with a sample of 60 dentally anxious young people using the CBT resource. This study will provide information on the profile of dentally anxious young people who could potentially be helped by a guided self-help CBT resource. It will gain the perceptions of dental care team members of guided self-help CBT for

  4. Technical feasibility study on polycarbonate solar panels

    NARCIS (Netherlands)

    Hackmann, M.M.; Meuwissen, M.H.H.; Bots, T.L.; Buijs, J.A.H.M.; Broek, K.M.; Kinderman, R.; Tanck, O.B.F.; Schuurmans, F.M.

    2004-01-01

    This paper describes a technical feasibility study on the application of polycarbonate (PC) plates in a superstrate photovoltaic module design. The lamination process was performed in a conventional laminator apparatus using low temperature curing (100°C) ethylene-vinyl-acetate (EVA) as the potting

  5. Renewable Energy Feasibility Study Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Rooney, Tim [Antares Group Inc.

    2013-10-30

    The Gila River Indian Community (GRIC or the Community) contracted the ANTARES Group, Inc. (“ANTARES”) to assess the feasibility of solar photovoltaic (PV) installations. A solar energy project could provide a number of benefits to the Community in terms of potential future energy savings, increased employment, environmental benefits from renewable energy generation and usage, and increased energy self-sufficiency. The study addresses a number of facets of a solar project’s overall feasibility, including: Technical appropriateness; Solar resource characteristics and expected system performance; Levelized cost of electricity (LCOE) economic assessment. The Gila River Indian Community (GRIC or the Community) contracted the ANTARES Group, Inc. (“ANTARES”) to prepare a biomass resource assessment study and evaluate the feasibility of a bioenergy project on Community land. A biomass project could provide a number of benefits to the Community in terms of increased employment, environmental benefits from renewable energy generation and usage, and increased energy self-sufficiency. The study addresses a number of facets of a biomass project’s overall feasibility, including: Resource analysis and costs; Identification of potential bioenergy projects; Technical and economic (levelized cost of energy) modeling for selected project configuration.

  6. Feasibility of shortening 14-day hybrid therapy while maintaining an excellent Helicobacter pylori eradication rate.

    Science.gov (United States)

    Wu, Jeng-Yih; Hsu, Ping-I; Wu, Deng-Chyang; Graham, David Y; Wang, Wen-Ming

    2014-06-01

    The need for new effective Helicobacter pylori eradication therapy has focused efforts on the development and optimization of regimens with excellent eradication rates such as 14-day hybrid therapy. This study evaluated whether the duration of hybrid therapy could be reduced while maintaining a high eradication rate and to examine the effect of antibiotic resistance on outcome. Three separate multicenter pilot studies were carried out concurrently. To reduce selection bias, eligible subjects were randomized to 10-day, 12-day, or 14-day hybrid therapy consisting of esomeprazole 40 mg and amoxicillin 1 gm twice daily for 10, 12, or 14 days plus clarithromycin 500 mg, and metronidazole 500 mg twice daily for the final 7 days. The primary outcome was H. pylori eradication per-protocol assessed at least 8 weeks after therapy. A total of 220 subjects were entered. The per-protocol analyses contained 60, 61, 61 subjects in the 10-, 12- and 14-day therapy studies, respectively. The eradication rates, per-protocol, were similar: 95% (95% confidence interval (CI); 89.5-100%) for 10-day, 95.1% (95% CI; 89.7-100%) for 12-day, and 93.4% (95% CI; 87.2-99.7%) for 14-day hybrid therapies. Antibiotic resistance was infrequent; however, all metronidazole or clarithromycin resistances were cured with 12- and 14-day therapies. These results suggest that in regions of moderate to low clarithromycin and/or metronidazole resistance it may be feasible to shorten hybrid therapy to 10 or 12 days. Further study is needed to compare hybrid and concomitant therapy in regions with moderate-to-high clarithromycin and/or metronidazole resistance. © 2014 John Wiley & Sons Ltd.

  7. Feasibility and initial effectiveness of home exercise during maintenance therapy for childhood acute lymphoblastic leukemia.

    Science.gov (United States)

    Esbenshade, Adam J; Friedman, Debra L; Smith, Webb A; Jeha, Sima; Pui, Ching-Hon; Robison, Leslie L; Ness, Kirsten K

    2014-01-01

    Children with acute lymphoblastic leukemia (ALL) are at increased risk of obesity and deconditioning from cancer therapy. This pilot study assessed feasibility/initial efficacy of an exercise intervention for patients with ALL undergoing maintenance therapy. Participants were aged 5 to 10 years, receiving maintenance therapy, in first remission. A 6-month home-based intervention, with written and video instruction, was supervised with weekly calls from an exercise coach. Pre- and poststudy testing addressed strength, flexibility, fitness, and motor function. Seventeen patients enrolled (participation 63%). Twelve (71%) finished the intervention, completing 81.7 ± 7.2% of prescribed sessions. Improvements of 5% or more occurred in 67% for knee and 75% for grip strength, 58% for hamstring/low-back and 83% for ankle flexibility, 75% for the 6-Minute Walk Test, and 33% for performance on the Bruininks-Oseretsky Test of Motor Proficiency Version 2. This pilot study demonstrated that exercise intervention during ALL therapy is feasible and has promise for efficacy.

  8. A feasibility study of a deuterium-deuterium neutron generator-based boron neutron capture therapy system for treatment of brain tumors.

    Science.gov (United States)

    Hsieh, Mindy; Liu, Yingzi; Mostafaei, Farshad; Poulson, Jean M; Nie, Linda H

    2017-02-01

    Boron neutron capture therapy (BNCT) is a binary treatment modality that uses high LET particles to achieve tumor cell killing. Deuterium-deuterium (DD) compact neutron generators have advantages over nuclear reactors and large accelerators as the BNCT neutron source, such as their compact size, low cost, and relatively easy installation. The purpose of this study is to design a beam shaping assembly (BSA) for a DD neutron generator and assess the potential of a DD-based BNCT system using Monte Carlo (MC) simulations. The MC model consisted of a head phantom, a DD neutron source, and a BSA. The head phantom had tally cylinders along the centerline for computing neutron and photon fluences and calculating the dose as a function of depth. The head phantom was placed at 4 cm from the BSA. The neutron source was modeled to resemble the source of our current DD neutron generator. A BSA was designed to moderate and shape the 2.45-MeV DD neutrons to the epithermal (0.5 eV to 10 keV) range. The BSA had multiple components, including moderator, reflector, collimator, and filter. Various materials and configurations were tested for each component. Each BSA layout was assessed in terms of the in-air and in-phantom parameters. The maximum brain dose was limited to 12.5 Gray-Equivalent (Gy-Eq) and the skin dose to 18 Gy-Eq. The optimized BSA configuration included 30 cm of lead for reflector, 45 cm of LiF, and 10 cm of MgF2 for moderator, 10 cm of lead for collimator, and 0.1 mm of cadmium for thermal neutron filter. Epithermal flux at the beam aperture was 1.0 × 105  nepi /cm2 -s; thermal-to-epithermal neutron ratio was 0.05; fast neutron dose per epithermal was 5.5 × 10-13  Gy-cm2 /φepi , and photon dose per epithermal was 2.4 × 10-13  Gy-cm2 /φepi . The AD, AR, and the advantage depth dose rate were 12.1 cm, 3.7, and 3.2 × 10-3  cGy-Eq/min, respectively. The maximum skin dose was 0.56 Gy-Eq. The DD neutron yield that is needed to irradiate in

  9. Gasohol: economic feasibility study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    David, M. L.; Hammaker, G. S.; Buzenberg, R. J.; Wagner, J. P.

    1978-07-01

    This report was prepared by Development Planning and Research Associates, Inc. under a contract with the Energy Research and Development Center of the University of Nebraska in cooperation with the Agricultural Products Industrial Utilization Committee and the State of Nebraska. Funding for this study was provided to the Energy Research and Development Center by the U.S. Department of Energy and the Old West Regional Commission. The primary objective of the study was to: determine the fiscal and market conditions under which the production of gasohol would be profitable for private producers. For purposes of this study, gasohol is a motor fuel consisting of 10 percent agriculturally-derived anhydrous ethanol and 90 percent unleaded gasoline. The study assumes that gasohol can be a fuel substitute for gasoline; indeed, the cost of gasoline will significantly influence that for gasohol. Gasoline prices are determined by factors external to ethanol; thus, the economic feasibility study of gasohol is in large part an economic feasibility study of fuel-grade ethanol production. More specifically, the study examined the following: the technical aspects of distributing, marketing, and using gasohol; the costs of the distribution and marketing of ethanol and gasohol; the energy balance of ethanol production; the cost of producing ethanol; the factors influencing ehtanol plant size and location; and the conditions that would make ethanol economicaly feasible for private producers.

  10. Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study

    Directory of Open Access Journals (Sweden)

    Nachega JB

    2016-04-01

    University, Cape Town, South Africa Objective: To examine the acceptability and feasibility of mobile health (mHealth/short message service (SMS and community-based directly observed antiretroviral therapy (cDOT as interventions to improve antiretroviral therapy (ART adherence for preventing mother-to-child human immunodeficiency virus (HIV transmission (PMTCT. Design and methods: A mixed-method approach was used. Two qualitative focus group discussions with HIV-infected pregnant women (n=20 examined the acceptability and feasibility of two ART adherence interventions for PMTCT: 1 SMS text messaging and 2 patient-nominated cDOT supporters. Additionally, 109 HIV-infected, pregnant South African women (18–30 years old receiving PMTCT services under single-tablet antiretroviral therapy regimen during pregnancy and breastfeeding and continuing for life (“Option B+” were interviewed about mobile phone access, SMS use, and potential treatment supporters. Setting: A community primary care clinic in Cape Town, South Africa. Participants: HIV-infected pregnant women. Main outcomes: Acceptability and feasibility of mHealth and cDOT interventions. Results: Among the 109 women interviewed, individual mobile phone access and SMS use were high (>90%, and 88.1% of women were interested in receiving SMS ART adherence support messages such as reminders, motivation, and medication updates. Nearly all women (95% identified at least one person close to them to whom they had disclosed their HIV status and would nominate as a cDOT supporter. Focus group discussions revealed that cDOT supporters and adherence text messages were valued, but some concerns regarding supporter time availability and risk of unintended HIV status disclosure were expressed. Conclusion: mHealth and/or cDOT supporter as interventions to improve ART adherence are feasible in this setting. However, safe HIV status disclosure to treatment supporters and confidentiality of text messaging content about HIV and ART were

  11. Balneotherapy Together with a Psychoeducation Program for Benzodiazepine Withdrawal: A Feasibility Study

    National Research Council Canada - National Science Library

    De Maricourt, P; Gorwood, P; Hergueta, Th; Galinowski, A; Salamon, R; Diallo, A; Vaugeois, C; Lépine, J. P; Olié, J. P; Dubois, O

    2016-01-01

    .... The aim of this study was to assess the feasibility and the impact of a program including cognitive behavioural therapy, psychoeducation, and balneotherapy in a spa resort to facilitate long-term...

  12. SU-E-J-104: Single Photon Image From PET with Insertable SPECT Collimator for Boron Neutron Capture Therapy: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Jung, J; Yoon, D; Suh, T [The catholic University of Korea, College of Medicine/Graduate School of Medicine, Seoul (Korea, Republic of); Hong, K [Molecular Imaging Program at Stanford (MIPS), Palo Alto, CA (United States)

    2014-06-01

    Purpose: The aim of our proposed system is to confirm the feasibility of extraction of two types of images from one positron emission tomography (PET) module with an insertable collimator for brain tumor treatment during the BNCT. Methods: Data from the PET module, neutron source, and collimator was entered in the Monte Carlo n-particle extended (MCNPX) source code. The coincidence events were first compiled on the PET detector, and then, the events of the prompt gamma ray were collected after neutron emission by using a single photon emission computed tomography (SPECT) collimator on the PET. The obtaining of full width at half maximum (FWHM) values from the energy spectrum was performed to collect effective events for reconstructed image. In order to evaluate the images easily, five boron regions in a brain phantom were used. The image profiles were extracted from the region of interest (ROI) of a phantom. The image was reconstructed using the ordered subsets expectation maximization (OSEM) reconstruction algorithm. The image profiles and the receiver operating characteristic (ROC) curve were compiled for quantitative analysis from the two kinds of reconstructed image. Results: The prompt gamma ray energy peak of 478 keV appeared in the energy spectrum with a FWHM of 41 keV (6.4%). On the basis of the ROC curve in Region A to Region E, the differences in the area under the curve (AUC) of the PET and SPECT images were found to be 10.2%, 11.7%, 8.2% (center, Region C), 12.6%, and 10.5%, respectively. Conclusion: We attempted to acquire the PET and SPECT images simultaneously using only PET without an additional isotope. Single photon images were acquired using an insertable collimator on a PET detector. This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communication Technologies (ICT) and Future Planning (MSIP)(Grant No

  13. Assessing the feasibility of injectable growth-promoting therapy in Crohn's disease.

    Science.gov (United States)

    Altowati, Mabrouka A; Jones, Ashley P; Hickey, Helen; Williamson, Paula R; Barakat, Farah M; Plaatjies, Nicolene C; Hardwick, Ben; Russell, Richard K; Jaki, Thomas; Ahmed, S Faisal; Sanderson, Ian R

    2016-01-01

    Despite optimal therapy, many children with Crohn's disease (CD) experience growth retardation. The objectives of the study are to assess the feasibility of a randomised control trial (RCT) of injectable forms of growth-promoting therapy and to survey the attitudes of children with CD and their parents to it. A feasibility study was carried out to determine study arms, sample size and numbers of eligible patients. A face-to-face questionnaire surveyed willingness to consent to future participation in the RCT. Eligibility to the survey was any child under 18 (with their parent/guardian) with CD whose height standard deviation score (HtSDS) was ≤+1. Of 118 questionnaires, 94 (80%) were returned (48 by children and 46 by parents). The median age of the patients in the survey was 14.3 years (range 7.0 to 17.7), and 35 (73%) were male. Their median HtSDS was -1.2 (-3.01, 0.23), and it was lower than the median mid-parental HtSDS of -0.6 (-3.1, 1.4). We analysed the willingness of the children whose HtSDS promoting therapy. Allaying fears about injections may result in higher recruitment rates.

  14. Dry powder inhalation of antibiotics in cystic fibrosis therapy : Part 2. Inhalation of a novel colistin dry powder formulation: A feasibility study in healthy volunteers and patients

    NARCIS (Netherlands)

    Le Brun, P P H; de Boer, A H; Mannes, G P M; de Fraîture, D M I; Brimicombe, R W; Touw, Daan; Vinks, A A; Frijlink, H W; Heijerman, H G M

    The aim of the present study was to perform a proof of principle study with a new colistin dry powder inhalation system in six healthy volunteers and five patients with cystic fibrosis. All subjects were asked to inhale 25 mg colistin sulfate dry powder. The patients were also asked to nebulize 160

  15. Feasibility

    OpenAIRE

    Bokdam, J.; Braeckel, van, Liesbeth

    2002-01-01

    Extensive livestock farming, including hay making, seems the most feasible management strategy for open peatland. In the longer term, wilderness grazing may become more feasible. The loss of economic viability of traditional livestock farming and related haymaking may be reversed by innovation of new marketable 'Biebrza' products, 'green services', e.g. eco- and agro-tourism, and by financial subventions by the EU and the Polish Government. Large scale mechanical harvesting of hay and litter ...

  16. Complementary alternative medical therapies for heart surgery patients: feasibility, safety, and impact.

    Science.gov (United States)

    Kshettry, Vibhu R; Carole, Linda Flies; Henly, Susan J; Sendelbach, Sue; Kummer, Barbara

    2006-01-01

    Complementary therapies (touch, music) are used as successful adjuncts in treatment of pain in chronic conditions. Little is known about their effectiveness in care of heart surgery patients. Our objective is to evaluate feasibility, safety, and impact of a complementary alternative medical therapies package for heart surgery patients. One hundred four patients undergoing open heart surgery were prospectively randomized to receive either complementary therapy (preoperative guided imagery training with gentle touch or light massage and postoperative music with gentle touch or light massage and guided imagery) or standard care. Heart rate, systolic and diastolic blood pressure, and pain and tension were measured preoperatively and as pre-tests and post-tests during the postoperative period. Complications were abstracted from the hospital record. Virtually all patients in the complementary therapy group (95%) and 86% in standard care completed the study. Heart rate and blood pressure patterns were similar. Decreases in heart rate and systolic blood pressure in the complementary therapies group were judged within the range of normal values. Complication rates were very low and occurred with similar frequency in both groups. Pretreatment and posttreatment pain and tension scores decreased significantly in the complementary alternative medical therapies group on postoperative days 1 (p < 0.01) and 2 (p < 0.038). The complementary medical therapies protocol was implemented with ease in a busy critical care setting and was acceptable to the vast majority of patients studied. Complementary medical therapy was not associated with safety concerns and appeared to reduce pain and tension during early recovery from open heart surgery.

  17. Feasibility of breast preserving therapy with single fraction in situ radiotherapy delivered intraoperatively.

    Science.gov (United States)

    Ollila, David W; Klauber-DeMore, Nancy; Tesche, Leora J; Kuzmiak, Cherie M; Pavic, Dag; Goyal, Lav K; Lian, Jun; Chang, Sha; Livasy, Chad A; Sherron, Rachel F; Sartor, Carolyn I

    2007-02-01

    Accelerated partial breast irradiation (APBI) has gained widespread interest as a means of improving the convenience and availability of breast conserving radiotherapy. Intraoperative radiation therapy (IORT) is an APBI technique that delivers breast radiotherapy as a single dose at the time of partial mastectomy. We adapted the technique of Veronesi to deliver IORT prior to tumor excision to improve delivery to the region at risk and reduce the volume of normal tissue irradiated. Patients age >or=55 with ultrasonographically defined tumors surgery using ultrasound tumor definition, selecting cone size and electron energy to optimize dose distribution. In the operating room, the surgeon retracted the skin over the tumor, cone was placed and radiotherapy delivered. Standard partial mastectomy was then performed. Twenty-three patients were enrolled in the study. Eighteen patients completed IORT with 10 patients having successful IORT no additional local therapy necessary. In five patients, the intraoperative radiation therapy served as the boost and in three patients unsuspected larger tumors or multicentric disease necessitated a mastectomy. The majority of patients had a good to excellent cosmetic result. Single fraction in situ IORT prior to partial mastectomy is feasible for patients with small breast cancers in achieving a good to excellent cosmetic result. Based on this early preliminary data, we plan to expand our feasibility trial.

  18. Feasibility of Group Voice Therapy for Individuals with Parkinson's Disease

    Science.gov (United States)

    Searl, Jeff; Wilson, Kristel; Haring, Karen; Dietsch, Angela; Lyons, Kelly; Pahwa, Rajesh

    2011-01-01

    Purpose: The primary purpose was to demonstrate the feasibility of executing treatment tasks focused on increasing loudness in a group format for individuals with Parkinson's disease (PD). A second purpose was to report preliminary pre-to-post treatment outcomes for individuals with PD immediately after they complete the group program. Methods:…

  19. Feasibility of prostate robotic radiation therapy on conventional C-arm linacs.

    Science.gov (United States)

    Dong, Peng; Nguyen, Dan; Ruan, Dan; King, Christopher; Long, Troy; Romeijn, Edwin; Low, Daniel A; Kupelian, Patrick; Steinberg, Michael; Yang, Yingli; Sheng, Ke

    2014-01-01

    Significant dosimetric improvement for radiation therapy using optimized noncoplanar fields has been previously demonstrated. The purpose here is to study the feasibility of optimized robotic noncoplanar radiation therapy, termed 4π therapy, for prostate cancer treatments on a conventional C-arm linac. Twelve low-risk prostate cancer patients previously treated by 2-arc volumetric modulated arc therapy (VMAT) were selected. Forty gray in 5 fractions were prescribed to cover 95% of the prostate planning target volume (PTV). To replan by 4π therapy, a column generation method was used to optimize beam orientations and fluence. A total of 30 beams were selected for each patient. Both planning methods provided adequate PTV coverage. Compared against VMAT plans, the 4π plan reduced the rectum V50%, V80%, V90%, D1cc, and the penile bulb maximum doses by 50%, 28%, 19% 11%, and 9% (P arm linac platform. Copyright © 2014 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

  20. Ketogenic dietary therapies for adults with epilepsy: feasibility and classification of response.

    Science.gov (United States)

    Schoeler, Natasha E; Wood, Susan; Aldridge, Valerie; Sander, Josemir W; Cross, J Helen; Sisodiya, Sanjay M

    2014-08-01

    Ketogenic dietary therapies are an effective treatment for children with drug-resistant epilepsy. There is currently no high-quality evidence regarding ketogenic dietary therapies in adults, and further research has been recommended. This audit aimed to provide further evidence for the feasibility of dietary treatment for adults and to consider factors that may aid response classification in this population. We evaluated the effectiveness and tolerability of ketogenic dietary therapies in 23 adults with epilepsy attending specialist clinics. Medical notes were used to obtain seizure frequency information and other effects associated with dietary treatment. Individuals who achieved ≥50% seizure reduction at all follow-up points were classified as responders. Response rates, in terms of seizure frequency, were similar to those commonly reported in pediatric cohorts: 9/23 (39%) adults were classified as responders. These responders remained on the diet for at least one year (follow-up: 1-10 years). Other benefits reported by patients, but not quantified, included a reduction in seizure severity and increased alertness and concentration. Such factors often favor continuation of ketogenic dietary therapies despite a ketogenic dietary therapies long-term, and such treatment can lead to seizure reduction. Other aspects besides seizure frequency may be relevant when classifying response in adults, and appropriate ways to quantify these factors should be considered for use in future studies. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Feasibility Study of EndoTAG-1, a Tumor Endothelial Targeting Agent, in Combination with Paclitaxel followed by FEC as Induction Therapy in HER2-Negative Breast Cancer.

    Directory of Open Access Journals (Sweden)

    Michail Ignatiadis

    - patients. Further studies are warranted with need of premedication optimization.ClinicalTrials.gov NCT01537536.

  2. Evaluating Por Nuestra Salud: A Feasibility Study.

    Science.gov (United States)

    Marshall, Brenda; Gonzales, Gustavo; Kernan, William

    2016-01-01

    This feasibility study evaluated the impact of a culturally consistent diabetes educational program, led by a Latino pastor, on Latino community diabetes knowledge levels. Latino adults were recruited from two churches serving Latino populations, one identified as intervention, the other as nonintervention. Both churches received the American Diabetes Association's booklets on diabetes education, "Four Steps to Control Your Diabetes for Life." The intervention group also received weekly reviews of the booklet's information from the church pastor, who was educated about diabetes by a Latino family nurse practitioner. Pre- and postintervention levels of diabetes knowledge were measured using the Diabetes Knowledge Questionnaire. Mean changes in the Diabetes Knowledge Questionnaire (DKQ-24) survey from pretest to posttest indicated a significant increase in knowledge in both groups. Only the grades for the participants from the pastor-led group, however, moved from failure in knowledge to high levels of passing. One hundred percent of intervention group participants reported having read the literature. This pilot study supports the feasibility of a local Latino pastor, as a culturally consistent diabetes educator, to increase Latino parishioner's knowledge of diabetes. © 2015 Society for Public Health Education.

  3. NASA CPAS Drogue Textile Riser Feasibility Study

    Science.gov (United States)

    Hennings, Elsa J.; Petersen, Michael L.; Anderson, Brian; Johnson, Brian

    2015-01-01

    Steel cable was chosen for the lower end of the drogue and main parachute risers on NASA's Orion Multi Purpose Crew Vehicle Parachute Assembly System (CPAS) to protect the risers from extreme temperatures and abrasion should they contact the crew module during deployment, as was done for Apollo. Due to the weight and deployment complexity inherent in steel, there was significant interest in the possibility of substituting textile for steel for the drogue and main parachute risers. However, textile risers could be damaged when subjected to high temperature and abrasion. Investigations were consequently performed by a subset of the authors to determine whether sacrificial, non-load-bearing textile riser covers could be developed to mitigate the thermal and abrasion concerns. Multiple material combinations were tested, resulting in a cover design capable of protecting the riser against severe riser/crew module contact interactions. A feasibility study was then conducted to evaluate the performance of the textile drogue riser cover in relevant abrasive environments. This paper describes the testing performed and documents the results of this feasibility study.

  4. [Hand allograft in agenesic newborn: feasibility study].

    Science.gov (United States)

    Gazarian, A; Abrahamyan, D O

    2007-10-01

    Would a newborn with a single hand benefit from hand allograft? Transantebrachial aplasia is the chosen clinical form of agenesia in our interrogation. The feasibility study presents several aspects: 1) ethical and psychological aspects. Is this a desired surgery for agenesic population? Which are the functional, psychological and social situations of agenesic patient? Is the hand transplantation in newborn ethically acceptable? What is the parents' attitude toward agenesia? Can we envisage organ donation in neonatal period? 2) immunological aspects. The non-vital character of this condition and its' good functional tolerance cannot make accepting the risk of adverse effects of hand allotransplantation. Hence, one may consider this surgery only without immunosuppression. Can the peculiarities of the neonate "immature" immune system represent an opportunity of easier tolerance obtaining, avoiding immunosuppression? 3) anatomical and technical aspects. The proximal tissues at the level of amputation are all hypoplastic in agenesic patients. Can we efficaciously suture those structures with donor eutrophic tissues? 4) cognitive aspects. Is a neonate born with only one hand is able to use two? A feasibility study on such a subject needs to take into account all these aspects. This research is useful because, even if hand allograft in agenesic newborn will never be done, the provided information will allow to progress in the vaster domain of composite tissue allotransplantation in perinatology.

  5. Selecting relevant and feasible measurement instruments for the revised Dutch clinical practice guideline for physical therapy in patients after stroke

    NARCIS (Netherlands)

    Otterman, N.; Veerbeek, J.; Schiemanck, S.; Wees, P.J. van der; Nollet, F.; Kwakkel, G.

    2017-01-01

    PURPOSE: To select relevant and feasible instruments for the revision of the Dutch clinical practice guideline for physical therapy in patients with stroke. METHODS: In this implementation study a comprehensive proposal for ICF categories and matching instruments was developed, based on reliability

  6. Feasibility of Using Video to Teach a Dialectical Behavior Therapy Skill to Clients with Borderline Personality Disorder

    Science.gov (United States)

    Waltz, Jennifer; Dimeff, Linda A.; Koerner, Kelly; Linehan, Marsha M.; Taylor, Laura; Miller, Christopher

    2009-01-01

    This study tested the feasibility of using a psychoeducational video recording to teach a behavioral skill from the Dialectical Behavior Therapy (DBT; Linehan, 1993a, 1993b) skills training program to individuals meeting criteria for borderline personality disorder. A video presenting a DBT emotion-regulation skill was developed and the extent to…

  7. Battery energy storage market feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Kraft, S. [Frost and Sullivan, Mountain View, CA (United States); Akhil, A. [Sandia National Labs., Albuquerque, NM (United States). Energy Storage Systems Analysis and Development Dept.

    1997-07-01

    Under the sponsorship of the Department of Energy`s Office of Utility Technologies, the Energy Storage Systems Analysis and Development Department at Sandia National Laboratories (SNL) contracted Frost and Sullivan to conduct a market feasibility study of energy storage systems. The study was designed specifically to quantify the energy storage market for utility applications. This study was based on the SNL Opportunities Analysis performed earlier. Many of the groups surveyed, which included electricity providers, battery energy storage vendors, regulators, consultants, and technology advocates, viewed energy storage as an important enabling technology to enable increased use of renewable energy and as a means to solve power quality and asset utilization issues. There are two versions of the document available, an expanded version (approximately 200 pages, SAND97-1275/2) and a short version (approximately 25 pages, SAND97-1275/1).

  8. Aleutian Pribilof Islands Wind Energy Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Bruce A. Wright

    2012-03-27

    Under this project, the Aleutian Pribilof Islands Association (APIA) conducted wind feasibility studies for Adak, False Pass, Nikolski, Sand Point and St. George. The DOE funds were also be used to continue APIA's role as project coordinator, to expand the communication network quality between all participants and with other wind interest groups in the state and to provide continued education and training opportunities for regional participants. This DOE project began 09/01/2005. We completed the economic and technical feasibility studies for Adak. These were funded by the Alaska Energy Authority. Both wind and hydro appear to be viable renewable energy options for Adak. In False Pass the wind resource is generally good but the site has high turbulence. This would require special care with turbine selection and operations. False Pass may be more suitable for a tidal project. APIA is funded to complete a False Pass tidal feasibility study in 2012. Nikolski has superb potential for wind power development with Class 7 wind power density, moderate wind shear, bi-directional winds and low turbulence. APIA secured nearly $1M from the United States Department of Agriculture Rural Utilities Service Assistance to Rural Communities with Extremely High Energy Costs to install a 65kW wind turbine. The measured average power density and wind speed at Sand Point measured at 20m (66ft), are 424 W/m2 and 6.7 m/s (14.9 mph) respectively. Two 500kW Vestas turbines were installed and when fully integrated in 2012 are expected to provide a cost effective and clean source of electricity, reduce overall diesel fuel consumption estimated at 130,000 gallons/year and decrease air emissions associated with the consumption of diesel fuel. St. George Island has a Class 7 wind resource, which is superior for wind power development. The current strategy, led by Alaska Energy Authority, is to upgrade the St. George electrical distribution system and power plant. Avian studies in Nikolski

  9. Feasibility Study for BioLEIR

    CERN Document Server

    Ghithan, S.; Schuh, S.

    2017-01-01

    The biomedical community asked CERN to investigate the possibility to transform the Low Energy Ion Ring (LEIR) accelerator into a multidisciplinary, biomedical research facil- ity (BioLEIR) that could provide ample, high-quality beams of a range of light ions suitable for clinically oriented fundamental research on cell cultures and for radiation instrumenta- tion development. BioLEIR would be operated when LEIR is not providing heavy ions for the CERN physics programme. The study group was mandated to write a Feasibility Study Report, using high-level engineering estimates based on previous experience, with the aim to: – collect the requirements for such a facility from the biomedical community in close collaboration with the International Strategy Committee for CERN Medical Applica- tions; – determine a coherent set of beam parameters, based on the requirements; – explore whether the beam requirements can be met throughout the facility, from the source to the biomedical end-stations; – perf...

  10. Lunar Wireless Power Transfer Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Freid, Sheldon [National Security Technologies, LLC. (NSTec), Mercury, NV (United States); Popovic, Zoya [Univ. of Colorado, Boulder, CO (United States); Beckett, David R. [Independent Consultant; Anderson, Scott R. [Independent Consultant; Mann, Diana [Independent Consultant; Walker, Stuart [Independent Consultant

    2008-03-01

    This study examines the feasibility of a multi-kilowatt wireless radio frequency (RF) power system to transfer power between lunar base facilities. Initial analyses, show that wireless power transfer (WPT) systems can be more efficient and less expensive than traditional wired approaches for certain lunar and terrestrial applications. The study includes evaluations of the fundamental limitations of lunar WPT systems, the interrelationships of possible operational parameters, and a baseline design approach for a notionial system that could be used in the near future to power remote facilities at a lunar base. Our notional system includes state-of-the-art photovoltaics (PVs), high-efficiency microwave transmitters, low-mass large-aperture high-power transmit antennas, high-efficiency large-area rectenna receiving arrays, and reconfigurable DC combining circuitry.

  11. Feasibility Study for Paragon - Bisti Solar Ranch

    Energy Technology Data Exchange (ETDEWEB)

    Benally, Thomas [Navajo Hopi Land Commission Office (NHLCO), Window Rock, AZ (United States)

    2015-06-01

    The Navajo Hopi Land Commission Office (NHLCO) and Navajo Nation (NN) plan to develop renewable energy (RE) projects on the Paragon-Bisti Ranch (PBR) lands, set aside under the Navajo Hopi Land Settlement Act (NHLSA) for the benefit of Relocatees. This feasibility study (FS), which was funded under a grant from DOE’s Tribal Energy Program (TEP), was prepared in order to explore the development of the 22,000-acre PBR in northwestern New Mexico for solar energy facilities. Topics covered include: • Site Selection • Analysis of RE, and a Preliminary Design • Transmission, Interconnection Concerns and Export Markets • Financial and Economic Analysis • Environmental Study • Socioeconomic and Cultural Factors • Next Steps.

  12. {sup 18}F-Choline Positron Emission Tomography/Computed Tomography–Driven High-Dose Salvage Radiation Therapy in Patients With Biochemical Progression After Radical Prostatectomy: Feasibility Study in 60 Patients

    Energy Technology Data Exchange (ETDEWEB)

    D' Angelillo, Rolando M., E-mail: r.dangelillo@unicampus.it [Radiation Oncology, Campus Bio-Medico University, Rome (Italy); Sciuto, Rosa [Department of Nuclear Medicine, Regina Elena National Cancer Institute, Rome (Italy); Ramella, Sara [Radiation Oncology, Campus Bio-Medico University, Rome (Italy); Papalia, Rocco [Department of Urology, Regina Elena National Cancer Institute, Rome (Italy); Jereczek-Fossa, Barbara A. [Department of Radiation Oncology, European Institute of Oncology, Milan (Italy); Department of Health Sciences, University of Milan, Milan (Italy); Trodella, Luca E.; Fiore, Michele [Radiation Oncology, Campus Bio-Medico University, Rome (Italy); Gallucci, Michele [Department of Urology, Regina Elena National Cancer Institute, Rome (Italy); Maini, Carlo L. [Department of Nuclear Medicine, Regina Elena National Cancer Institute, Rome (Italy); Trodella, Lucio [Radiation Oncology, Campus Bio-Medico University, Rome (Italy)

    2014-10-01

    Purpose: To retrospectively review data of a cohort of patients with biochemical progression after radical prostatectomy, treated according to a uniform institutional treatment policy, to evaluate toxicity and feasibility of high-dose salvage radiation therapy (80 Gy). Methods and Materials: Data on 60 patients with biochemical progression after radical prostatectomy between January 2009 and September 2011 were reviewed. The median value of prostate-specific antigen before radiation therapy was 0.9 ng/mL. All patients at time of diagnosis of biochemical recurrence underwent dynamic {sup 18}F-choline positron emission tomography/computed tomography (PET/CT), which revealed in all cases a local recurrence. High-dose salvage radiation therapy was delivered up to total dose of 80 Gy to 18F-choline PET/CT-positive area. Toxicity was recorded according to the Common Terminology Criteria for Adverse Events, version 3.0, scale. Results: Treatment was generally well tolerated: 54 patients (90%) completed salvage radiation therapy without any interruption. Gastrointestinal grade ≥2 acute toxicity was recorded in 6 patients (10%), whereas no patient experienced a grade ≥2 genitourinary toxicity. No grade 4 acute toxicity events were recorded. Only 1 patient (1.7%) experienced a grade 2 gastrointestinal late toxicity. With a mean follow-up of 31.2 months, 46 of 60 patients (76.6%) were free of recurrence. The 3-year biochemical progression-free survival rate was 72.5%. Conclusions: At early follow-up, {sup 18}F-choline PET/CT-driven high-dose salvage radiation therapy seems to be feasible and well tolerated, with a low rate of toxicity.

  13. Exoskeleton for Soldier Enhancement Systems Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, J.F.

    2000-09-28

    The development of a successful exoskeleton for human performance augmentation (EHPA) will require a multi-disciplinary systems approach based upon sound biomechanics, power generation and actuation systems, controls technology, and operator interfaces. The ability to integrate key components into a system that enhances performance without impeding operator mobility is essential. The purpose of this study and report are to address the issue of feasibility of building a fieldable EHPA. Previous efforts, while demonstrating progress and enhancing knowledge, have not approached the level required for a fully functional, fieldable system. It is doubtless that the technologies required for a successful exoskeleton have advanced, and some of them significantly. The question to be addressed in this report is have they advanced to the point of making a system feasible in the next three to five years? In this study, the key technologies required to successfully build an exoskeleton have been examined. The primary focus has been on the key technologies of power sources, actuators, and controls. Power sources, including internal combustion engines, fuel cells, batteries, super capacitors, and hybrid sources have been investigated and compared with respect to the exoskeleton application. Both conventional and non-conventional actuator technologies that could impact EHPA have been assessed. In addition to the current state of the art of actuators, the potential for near-term improvements using non-conventional actuators has also been addressed. Controls strategies, and their implication to the design approach, and the exoskeleton to soldier interface have also been investigated. In addition to these key subsystems and technologies, this report addresses technical concepts and issues relating to an integrated design. A recommended approach, based on the results of the study is also presented.

  14. Feasibility study on ABWR full MOX core

    Energy Technology Data Exchange (ETDEWEB)

    Yagi, Makoto; Nagano, Mamoru; Sakurai, Shungo [Toshiba Corp., Yokohama (Japan)

    1996-12-31

    Mixed-oxide (MOX) fuels will be utilized as reload fuels in some existing commercial boiling water reactors (BWRs) in Japan around the year 2000. The first step MOX fuel is expected to have an average discharge exposure of 33 GWd/t and to be loaded within one-third of all fuel rods in a core. On the other hand, it becomes necessary to minimize the number of MOX fuels and plants utilizing MOX fuel, mainly because of fuel economy, handling, and site inspection costs. Under these situations, it is important to develop higher burnup MOX fuel containing more plutonium and a core with a larger amount of MOX fuel. The purpose of this study is to clarify the feasibility of high-burnup MOX fuel and core through the evaluation of nuclear characteristics.

  15. Bin Set 1 Calcine Retrieval Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    R. D. Adams; S. M. Berry; K. J. Galloway; T. A. Langenwalter; D. A. Lopez; C. M. Noakes; H. K. Peterson; M. I. Pope; R. J. Turk

    1999-10-01

    At the Department of Energy's Idaho Nuclear Technology and Engineering Center, as an interim waste management measure, both mixed high-level liquid waste and sodium bearing waste have been solidified by a calculation process and are stored in the Calcine Solids Storage Facilities. This calcined product will eventually be treated to allow final disposal in a national geologic repository. The Calcine Solids Storage Facilities comprise seven ''bit sets.'' Bin Set 1, the first to be constructed, was completed in 1959, and has been in service since 1963. It is the only bin set that does not meet current safe-shutdown earthquake seismic criteria. In addition, it is the only bin set that lacks built-in features to aid in calcine retrieval. One option to alleviate the seismic compliance issue is to transport the calcine from Bin Set 1 to another bin set which has the required capacity and which is seismically qualified. This report studies the feasibility of retrieving the calcine from Bi n Set 1 and transporting it into Bin Set 6 which is located approximately 650 feet away. Because Bin Set 1 was not designed for calcine retrieval, and because of the high radiation levels and potential contamination spread from the calcined material, this is a challenging engineering task. This report presents preconceptual design studies for remotely-operated, low-density, pneumatic vacuum retrieval and transport systems and equipment that are based on past work performed by the Raytheon Engineers and Constructors architectural engineering firm. The designs presented are considered feasible; however, future development work will be needed in several areas during the subsequent conceptual design phase.

  16. 7 CFR 1980.442 - Feasibility studies.

    Science.gov (United States)

    2010-01-01

    ... management, nature and extent of market area, marketing plans for sale of projected output, extent of...) PROGRAM REGULATIONS (CONTINUED) GENERAL Business and Industrial Loan Program § 1980.442 Feasibility...) Management feasibility. Evidence that continuity and adequacy of management has been evaluated and documented...

  17. A maximum feasible subset algorithm with application to radiation therapy

    DEFF Research Database (Denmark)

    Sadegh, Payman

    1999-01-01

    . The algorithm relies on an iterative constraint removal procedure where constraints are eliminated from a set proposed by solutions to minmax linear programs. The method is illustrated by a simulated example of a linear system with double sided bounds and a case from the area of radiation therapy....

  18. Moving with music for stroke rehabilitation: a sonification feasibility study.

    Science.gov (United States)

    Scholz, Daniel S; Rhode, Sönke; Großbach, Michael; Rollnik, Jens; Altenmüller, Eckart

    2015-03-01

    Gross-motor impairments are common after stroke, but efficacious and motivating therapies for these impairments are scarce. We present a novel musical sonification therapy especially designed to retrain gross-motor functions. Four stroke patients were included in a clinical pre-post feasibility study and were trained with our sonification training. Patients' upper-extremity functions and their psychological states were assessed before and after training. The four patients were subdivided into two groups, with both groups receiving 9 days of musical sonification therapy (music group, MG) or a sham sonification training (control group, CG). The only difference between these training protocols was that, in the CG, no sound was played back. During the training the patients initially explored the acoustic effects of their arm movements, and at the end of the training the patients played simple melodies by moving their arms. The two patients in the MG improved in nearly all motor function tests after the training. They also reported in the stroke impact scale, which assesses well-being, memory, thinking, and social participation, to be less impaired by the stroke. The two patients in the CG did benefit less from the movement training. Taken together, musical sonification may be a promising therapy for impairments after stroke. © 2015 New York Academy of Sciences.

  19. [Home telemonitoring of CPAP: a feasibility study].

    Science.gov (United States)

    Fraysse, J L; Delavillemarque, N; Gasparutto, B; Leophonte, P; Leseux, L; Humeau, M P; Racineux, J L; Muir, J F; Didier, A

    2012-01-01

    The most commonly used treatment for the sleep apnoea syndrome (SAS) is the application of constant positive airway pressure (CPAP) during sleep. Compliance is an essential element in the efficiency of CPAP. This is dependent on the quality of the management of care and on the education of the patients. With the emergence of telemedicine, telemonitoring of CPAP has been developed in France. This study will be observational and multicentered. The main aim is to evaluate the feasibility of CPAP telemonitoring in SAS patients (n=90). During the installation of the equipment, the patients will be instructed how to connect the CPAP Secure Digital card to a data transmitting box every week for two months. The actual number and frequency of remote-monitoring box connections will be recorded. The data transmission will be made to the study coordinator, the home care provider SADIR, by the way of a telemedicine platform, located in France. This study will allow measurement of the adherence of the patients to their CPAP treatment by telemonitoring using this new tool of data transmission and the impact of this on CPAP compliance. Copyright © 2011 SPLF. Published by Elsevier Masson SAS. All rights reserved.

  20. BIOMASS-TO-ENERGY FEASIBILITY STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Cecil T. Massie

    2002-09-03

    The purpose of this study was to assess the economic and technical feasibility of producing electricity and thermal energy from biomass by gasification. For an economic model we chose a large barley malting facility operated by Rahr Malting Co. in Shakopee, Minnesota. This plant provides an excellent backdrop for this study because it has both large electrical loads and thermal loads that allowed us to consider a wide range of sizes and technical options. In the end, eleven scenarios were considered ranging from 3.1 megawatts (MWe) to 19.8 MWe. By locating the gasification and generation at an agricultural product processing plant with large electrical and thermal loads, the expectation was that some of the limitations of stand-alone biomass power plants would be overcome. In addition, since the process itself created significant volumes of low value biomass, the hope was that most of the biomass gathering and transport issues would be handled as well. The development of low-BTU gas turbines is expected to fill a niche between the upper limit of multiple spark ignited engine set systems around 5 MWe and the minimum reasonable scale for steam turbine systems around 10 MWe.

  1. e-Therapy to reduce emotional distress in women undergoing assisted reproductive technology (ART): a feasibility randomized controlled trial.

    Science.gov (United States)

    van Dongen, Angelique J C M; Nelen, Willianne L D M; IntHout, Joanna; Kremer, Jan A M; Verhaak, Christianne M

    2016-05-01

    Is it feasible to evaluate a personalized e-therapy program (Internet based) for women during fertility treatment aimed to reduce the chance of having clinically relevant symptoms of anxiety and/or depression after unsuccessful assisted reproductive technology (ART) treatment within a randomized controlled trial (RCT)? The evaluation of a personalized e-therapy program is feasible, reflected by good acceptability and integration within current guidelines, but adjustments to the e-therapy program and study design of the RCT have to be made to enhance demand, practicality and efficacy. Internet-based interventions are promising in reducing psychological distress, especially when treatment is personalized to specific risk profiles of patients. However in fertility care, the beneficial effects of personalized e-therapy on psychological distress and its implementation in daily clinical care still have to be evaluated. To evaluate the feasibility of a personalized e-therapy program, we conducted a two-arm, parallel group, single-blind feasibility randomized controlled trial with a 1:1 allocation. Feasibility was assessed in terms of demand, acceptability, practicality, implementation, integration and limited efficacy. Women were included between 1 February 2011 and 1 June 2013. Women in the control group received care as usual, whereas women in the intervention group received in addition to their usual care access to a personalized e-therapy program. Women were monitored until 3 months after the start of their first ART cycle. In a university hospital in the Netherlands women who were screened as at risk for emotional adjustment problems and intended to start their first ART cycle were invited, and of them 120 were randomized. Of these women, 48% in the intervention group were compliant to the intervention. Outcome measures associated with the feasibility to analyse this e-therapy program within an RCT were assessed. It is feasible to evaluate a personalized e-therapy

  2. A magnetotelluric feasibility study of the Alps

    Science.gov (United States)

    Ritter, O.; Weckmann, U.

    2016-12-01

    The Alps are a famous and extensive mountain range system in central Europe. The mountains were formed as the African and Eurasian tectonic plates collided and they have been a prime target for geological and geophysical investigations since the beginning of modern geosciences. Consequently, the Alps have been investigated with active and passive seismological methods and extensive sets of potential field data exist. Hardly anything is known, however, about the deep electrical conductivity structure, as it has been notoriously difficult to acquire magnetotelluric (MT) data in the Alps. The Alps are densely populated and a lot of infrastructure for tourism has been built over the years. MT measurements, which rely on natural variations of the electromagnetic background fields, are severely hampered by this man-made noise. Here, we report on a feasibility study to acquire MT data in the Alps, where all stations are deployed outside the valleys, on high mountain ranges and alpine pastures. Overall we recorded MT data at 7 stations, along an approximately north-south profile centred on Mayrhofen in the Austrian Alps. The average station spacing was 5 kilometers. The data were processed using robust remote-reference processing and the results clearly show that MT measurements are feasible. We used Mare2DEM for 2D inversion to include a somewhat realistic topography. The 2D section indicates moderate resistivity for the top 2 - 5 km, consistent with the regional geology, which suggests (meta-) sedimentary sequences. From depths of 5 km and below resistivities exceed 5,000 Ohmm. This means we can sense very deep with MT but also, that we should be cautious with an interpretation of this short profile. The data also clearly indicate 3D effects. We therefore propose to deploy an array of stations covering the entire Alps in USArray style, e.g. with a station spacing of approximately 50 km, to derive a 3D model of the deep electrical resistivity structure of the Alps. Such a

  3. Pinellas Plant feasibility study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-09-01

    The Pinellas Plant was built in 1956 to manufacture neutron generators, a principal component in nuclear weapons. In September 1990, the Department of Health and Rehabilitative Services (HRS) entered into an agreement with DOE to independently examine environmental monitoring data from the plant and health data from Pinellas County to determine if an epidemiological study is technically feasible to measure possible off-site health effects from ionizing radiation. Through normal plant operations, some radioactive materials have been released to the environment. Eighty percent of the total plant releases of 107,707 curies occurred in the early years of plant operation (1957--1960). The primary materials released were tritium gas, tritium oxide and krypton-85. Environmental monitoring for radioactive releases from the plant has been done regularly since 1975. The US Public Health Service Centers for Disease Control and Prevention (CDC), in assisting HRS, has determined that sufficient radiological data exist by which a dose reconstruction can be done. A dose reconstruction can provide an estimate of how much radiological exposure someone living in the vicinity of the Pinellas Plant may have suffered from environmental releases.

  4. Mindfulness-based cognitive therapy for bipolar disorder: a feasibility trial.

    Science.gov (United States)

    Weber, B; Jermann, F; Gex-Fabry, M; Nallet, A; Bondolfi, G; Aubry, J-M

    2010-10-01

    The present open study investigates the feasibility of Mindfulness-based cognitive therapy (MBCT) in groups solely composed of bipolar patients of various subtypes. MBCT has been mostly evaluated with remitted unipolar depressed patients and little is known about this treatment in bipolar disorder. Bipolar outpatients (type I, II and NOS) were included and evaluated for depressive and hypomanic symptoms, as well as mindfulness skills before and after MBCT. Patients' expectations before the program, perceived benefit after completion and frequency of mindfulness practice were also recorded. Of 23 included patients, 15 attended at least four MBCT sessions. Most participants reported having durably, moderately to very much benefited from the program, although mindfulness practice decreased over time. Whereas no significant increase of mindfulness skills was detected during the trial, change of mindfulness skills was significantly associated with change of depressive symptoms between pre- and post-MBCT assessments. MBCT is feasible and well perceived among bipolar patients. Larger and randomized controlled studies are required to further evaluate its efficacy, in particular regarding depressive and (hypo)manic relapse prevention. The mediating role of mindfulness on clinical outcome needs further examination and efforts should be provided to enhance the persistence of meditation practice with time. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  5. Accelerated hypofractionated adjuvant whole breast radiation with simultaneous integrated boost using volumetric modulated arc therapy for early breast cancer: A phase I/II dosimetric and clinical feasibility study from a tertiary cancer care centre of India

    Directory of Open Access Journals (Sweden)

    Dodul Mondal

    2017-03-01

    Mini abstract: Simultaneous integrated boost with accelerated hypofractionated whole breast radiotherapy using Volumetric Modulated Arc Therapy is a novel approach. Patient selection and technical considerations are of paramount importance. The present study describes successful implementation of this approach.

  6. Cognitive-Behavioral Therapy for Suicide Prevention (CBT-SP): Treatment Model, Feasibility, and Acceptability

    Science.gov (United States)

    Stanley, Barbara; Brown, Gregory; Brent, David A.; Wells, Karen; Poling, Kim; Curry, John; Kennard, Betsy D.; Wagner, Ann; Cwik, Mary F.; Klomek, Anat Brunstein; Goldstein, Tina; Vitiello, Benedetto; Barnett, Shannon; Daniel, Stephanie; Hughes, Jennifer

    2009-01-01

    Objective: To describe the elements of a manual-based cognitive-behavioral therapy for suicide prevention (CBT-SP) and to report its feasibility in preventing the recurrence of suicidal behavior in adolescents who have recently attempted suicide. Method: The CBT-SP was developed using a risk reduction and relapse prevention approach and…

  7. Efficacy and Feasibility of Intensity-Modulated Radiation Therapy for Prostate Cancer in Renal Transplant Recipients.

    Science.gov (United States)

    Iizuka, J; Hashimoto, Yas; Hashimoto, Yai; Kondo, T; Takagi, T; Nozaki, T; Shimizu, T; Akimoto, T; Ishida, H; Karasawa, K; Tanabe, K

    2016-04-01

    In transplant patients with localized prostate cancer, irradiation is not proposed as often as it is in healthy adults because of the post-radiation risks, such as ureteral stenosis and gastrointestinal toxicity as the result of fragile tissue. The objective of the study was to analyze the efficacy and feasibility of intensity-modulated radiation therapy (IMRT) for prostate cancer in renal transplant recipients (RTRs). Between May 2005 and December 2014, all patients who had undergone IMRT for clinically localized prostate cancer at our institution were retrospectively identified (n = 365). Of these patients, 2 had a history of renal transplantation. We reviewed all available clinical data. One patient had a functioning graft and the other had restarted hemodialysis 7 years after the transplantation. The mean time from renal transplantation to prostate cancer diagnosis was 11 years. The mean follow-up after irradiation was 43 months. The 2 patients remain free of prostate-specific antigen progression. There was no severe acute and chronic genitourinary and gastrointestinal toxicity. Renal function of the patient with a functioning graft as measured by serum creatinine was stable during and after the irradiation. IMRT is feasible and acceptable as a minimally invasive treatment in the carefully selected RTRs with localized prostate cancer. This treatment should be considered a good option for RTRs with localized prostate cancer. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. The Feasibility of a Culturally Informed Group Therapy for Patients With Schizophrenia and Their Family Members.

    Science.gov (United States)

    Maura, Jessica; Weisman de Mamani, Amy

    2017-06-29

    Research suggests that group-based psychosocial treatments for schizophrenia provide benefits to patients and family members alike. However, few existing treatments consider cultural factors that may enhance their efficacy with diverse populations. The current study examined the feasibility of a culturally informed group therapy for schizophrenia (CIGT-S), which incorporates collectivistic principles and spiritual coping into the treatment protocol. The feasibility of the group protocol was tested by examining differences in patient symptom severity and patient and family member depression, anxiety, and stress after completion of the group program. Within-groups analyses were conducted comparing baseline data to group termination data from 12 patients and 11 family members. Additionally, between-groups analyses were conducted comparing waitlist termination data from 20 patients and 13 family members to group termination data from 12 patients and 11 family members. Finally, we examined participant satisfaction with the group protocol, including qualitative reports on components of the protocol that participants deemed most valuable. Results indicated that patients demonstrated lower levels of symptom severity upon completion of the CIGT-S program; however, no other significant effects were found. Results examining overall patient and family member satisfaction with the treatment protocol indicated that patients and family members both reported being highly satisfied by the treatment program. This was also represented in participant's open-ended responses to our satisfaction questionnaire. These findings indicate that CIGT-S may represent a feasible, cost-effective approach that can be flexibly used with patients and family members of diverse racial and ethnic backgrounds. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  9. Feasibility Study on Lunar and Mars Exploration

    Science.gov (United States)

    Mori, Hidehiko; Takazawa, Yoshisada; Kaneko, Yutaka; Kawazoe, Takeshi; Takano, Yutaka; Namura, Eijiro

    1996-10-01

    This technical memorandum summarizes the results of an in-house study on lunar and Mars drone explorations - observation, landing and mobile explorations and sample returns for lunar and Mars respectively. So far, lunar and planet explorations have been primarily performed by the United States and the Soviet Union. ISAS and ESA have also contributed to some extent. The main purpose has been scientific exploration. There are some arguments that lunar and planet explorations should be performed for scientific purposes and the exploitation of them is not necessary. However, most scientific research involve the existence and survival of humankind, so it is not the fact that they cannot be organized from the side of exploitation. Especially, if NASDA makes approaches to lunar and Mars exploration, it should inevitably embrace exploitation plans. In this preface we provide the outline of lunar and Mars exploitation scenarios set up as a premise of the review on lunar and Mars unmanned exploration plans. Various reviews have been performed on whether the Moon or Mars would allow for human activities or survival. Among them, He mill, the solar powered satellite material mill and construction project of relay station to Mars as well as Mars teraforming plan have important issues. These projects have not yet become feasible because their expected investments are too large to make them practical. However, the present time seems the most appropriate to get with lunar and Mars exploitation projects under international cooperation since the realization of a space station is imminent and the international cooperation is being created with the participation of Russia. The international space station project will be continued until the year 2015. The post project has not yet been decided. Therefore, we expect that Japan would propose two successive projects, one is to construct an orbital service station combining manned abilities of the station and orbital service system and the

  10. Feasibility of a pedometer-based walking program for survivors of breast and head and neck cancer undergoing radiation therapy.

    Science.gov (United States)

    Javaheri, Pantea Amin; Nekolaichuk, Cheryl; Haennel, Robert; Parliament, Matthew B; McNeely, Margaret L

    2015-01-01

    This pilot study assessed the feasibility and acceptability of a pedometer-based walking program for people with breast cancer and head and neck cancer (HNC) undergoing radiation therapy treatment. Participants were given a pedometer and prescribed a home-based walking program that included an individualized weekly step-count goal during the 3- to 5-week course of radiation therapy. Feasibility was determined by calculating recruitment rate, completion rate, and rate of adherence. Secondary outcomes included 6-minute walk test (6MWT) distance, step count, physical activity level, and psychological outcomes of depression, happiness, self-esteem, and sleep quality. A total of 21 participants were recruited. All participants completed the study; adherence to prescribed step counts was 91% at follow-up. Analysis found a significant improvement in happiness, as measured by the Oxford Happiness Questionnaire (mean difference 0.3, p=0.003), and a borderline significant improvement in 6MWT distance (mean difference 35 m, p=0.008). This pilot study demonstrated the feasibility of a pedometer-based walking program for survivors of breast cancer and HNC undergoing radiation therapy.

  11. Feasibility Study of Thin Film Thermocouple Piles

    Science.gov (United States)

    Sisk, R. C.

    2001-01-01

    Historically, thermopile detectors, generators, and refrigerators based on bulk materials have been used to measure temperature, generate power for spacecraft, and cool sensors for scientific investigations. New potential uses of small, low-power, thin film thermopiles are in the area of microelectromechanical systems since power requirements decrease as electrical and mechanical machines shrink in size. In this research activity, thin film thermopile devices are fabricated utilizing radio frequency sputter coating and photoresist lift-off techniques. Electrical characterizations are performed on two designs in order to investigate the feasibility of generating small amounts of power, utilizing any available waste heat as the energy source.

  12. A feasibility study of nuclear superfluorescence

    Science.gov (United States)

    Balko, B.; Kay, I. W.; Neuberger, J. W.

    A theory of nuclear superfluorescence (SF) based on the Haake-Reibold model for the atomic case is presented. Certain modifications of the model make it possible to take into account some effects that are more important in nuclear than in atomic SF: attenuation, competing transitions, finite pumping times, and both homogeneous and inhomogeneous line broadening. Results of some explicit calculations illustrate the influence of these effects on the radiated pulse. Similar calculations are used to examine the feasibility of observing SF using the 58.6 keV transition in Co-60.

  13. High-intensity focused ultrasound to treat primary hyperparathyroidism: a feasibility study in four patients

    DEFF Research Database (Denmark)

    Kovatcheva, Roussanka D; Vlahov, Jordan D; Shinkov, Alexander D

    2010-01-01

    Many patients with primary hyperparathyroidism either decline or are not candidates for surgical parathyroidectomy. There are drawbacks to medical therapy as well as percutaneous ethanol injection as alternative therapies for primary hyperparathyroidism. Therefore, in this pilot study, our aim...... was to test the feasibility, safety, and efficacy of a newly developed noninvasive high-intensity focused ultrasound (HIFU) technique for the nonsurgical management of primary hyperparathyroidism....

  14. Acupuncture therapy for infants: a preliminary report on reasons for consultation, feasibility, and tolerability.

    Science.gov (United States)

    Gentry, Katherine R; McGinn, Kathleen L; Kundu, Anjana; Lynn, Anne M

    2012-07-01

      The aim of this retrospective review was to determine the feasibility, safety, and potential therapeutic effects of acupuncture in an inpatient infant population and to obtain data that would support the design of a randomized, controlled trial of acupuncture in infants.   Hospitalized infants are often exposed to sedative and analgesic medications to facilitate intensive and invasive medical care. With increasing concern about the potential neurotoxic effects of common analgesic and sedative medications, minimizing an infant's exposure to such agents is desirable. Acupuncture can be therapeutic in adults and children, but data in infants are lacking.   We performed a retrospective chart review of infants who received acupuncture during hospitalizations between 2008 and 2010. Demographic data, diagnoses, reason for acupuncture consult, ventilator settings, sedative/analgesic medication regimens, details of acupuncture therapy, and adverse effects were among data collected.   Ten infants were identified in this review, seven of whom had agitation issues, two of whom had feeding difficulties, and one had both symptoms. Six of the eight infants with agitation had a decrease in the use of sedative and analgesic medications over the acupuncture therapy period, and four of five initially requiring mechanical ventilation were successfully weaned. One of the three infants with oral aversion transitioned rapidly to oral intake. Acupuncture therapy was well tolerated, and there were no complications observed.   In this small group of hospitalized infants, acupuncture was found to be safe, well tolerated, and therapeutic. More studies are warranted to define the role of acupuncture in this population. © 2011 Blackwell Publishing Ltd.

  15. Testing the feasibility of the Dignity Therapy interview: adaptation for the Danish culture

    Directory of Open Access Journals (Sweden)

    Kristjanson Linda J

    2010-09-01

    Full Text Available Abstract Background 'Dignity Therapy' (DT is a brief, flexible intervention, which allows patients to complete an interview and create a document regarding their life, identity and what they want to leave in writing for their loved ones. DT is based on the DT Question Protocol. Developed and tested in English speaking settings, DT has proven to be a feasible and effective way to enhance patient dignity, while diminishing suffering and depression. The aim of this study was to test the acceptability and feasibility of the DT Question Protocol among Danish health professionals and cancer patients, and to obtain preliminary estimates of patient uptake for DT. These results will be used to inform a larger evaluation study. Method Ten professionals were interviewed about their perception of DT and the Question Protocol. It was then tested with 20 patients at two palliative care sites and one gynecologic oncology department. Data was analyzed using content analysis techniques to evaluate the protocol for relevance, acceptability and comprehension. The interest and relevance of the intervention was also determined by examining the preliminary participation rate. Results Overall, DT was perceived to be comprehensible and relevant. Professionals highlighted six concerns that might warrant modification. These issues were examined using patient data. Some of their concerns overlapped with those raised by the professionals (e.g. 'unacceptable self-praise' and 'interference with the lives of others'. Tailoring DT to Danish culture required easily accommodated adjustments to the procedures and the DT Question Protocol. Some concerns expressed by health professionals may have reflected protectiveness toward the patients. While the intervention was relevant and manageable for patients admitted to palliative care, DT was less easily implemented at the gynecologic oncology department. Conclusion Based on patients' and professionals' reaction to the DT Question

  16. Feasibility Study on the Development of Proton Accelerator II

    Energy Technology Data Exchange (ETDEWEB)

    Whang, Ki Woong [Korea Accelerator and Plasma Research Association, Seoul (Korea, Republic of)

    1997-09-01

    Present status and research trend of KOMAC (Korea Multipurpose Accelerator Complex)-grade accelerator construction in Europe, Japan, America, and Russia are surveyed in view of basic nuclear technology study in 2nd feasibility study on the KOMAC. KOMAC can be applied to study the increasing of nuclear reactor safety, the Proto-plant of transmutation technology for low cost nuclear fuel, the nuclear data production, the life science, mechanical dynamics, the structure probe, the radioisotope production, the cancer therapy, and the defense industry etc. And also KOMAC structure selection is investigated in point of utilization aims referred from various proposal of LANL and ORNL in USA, Neutron Science Research program in Japan, Energy Amplifier in Europe, and Institute of Theoretical and Experimental physics in Russia. As a result of meeting, study team is approached to the conclusion the KOMAC should be constructed to get the nuclear transmutation technology and the world leadership in future nuclear industry. Member`s opinion of study team agreed new nuclear technology, such as Accelerator Driven Energy Amplifier will be possible to sustain a survival of human being in post 21c. 7 tabs., 10 figs. (author)

  17. Evaluating the feasibility and the potential efficacy of e-learning-based speech therapy (EST) as a web application for speech training in dysarthric patients with Parkinson's disease: a case study.

    NARCIS (Netherlands)

    Beijer, L.J.; Rietveld, T.C.; Hoskam, V.; Geurts, A.C.H.; Swart, B.J.M. de

    2010-01-01

    OBJECTIVE: As a Web application for speech training, e-learning-based speech therapy (EST) is assumed to have potential for neurological patients who aim at independent speech training in their home environment. This article reports a case study of a patient with dysarthric speech due to Parkinson's

  18. A 12-week interdisciplinary rehabilitation trial in patients with gliomas - a feasibility study.

    Science.gov (United States)

    Hansen, Anders; Søgaard, Karen; Minet, Lisbeth Rosenbek; Jarden, Jens Ole

    2017-03-12

    This report aims to assess the safety and feasibility of using an interdisciplinary rehabilitation intervention for a future randomized controlled trial in patients with gliomas in the initial treatment phase. We conducted an outpatient two-part rehabilitation intervention that involved six weeks of therapeutic supervised training (part one) and six weeks of unsupervised training in a local gym following a training protocol (part two). Predefined feasibility objectives of safety (100%), consent rate (>80%), drop-out (80%) and patient satisfaction (>80%) was achieved at part one. However, the failure to meet predefined feasibility objectives of drop-out, adherence and patient satisfaction of the unsupervised intervention at part two have led to a protocol revision for a future randomized controlled trial. This study demonstrates that an intensive rehabilitation intervention of physical therapy and occupational therapy in the initial treatment phase of patients with gliomas whose Karnofsky performance status is ≥70 is safe and feasible, if relevant inclusion criteria and precautionary screening are made. With the revised protocol, we are confident that the foundation for conducting a successful randomized controlled trial among these vulnerable patients has been established. Implications for rehabilitation Brain tumors constitute some of the most challenging cancer diagnoses presenting for rehabilitation intervention. Patients with gliomas experiences limitations in physical functioning, cognition, and emotional wellbeing. In a relatively small sample this study shows that supervised physical- and occupational therapy in patients with gliomas is safe and feasible in the initial treatment phase. Patients with gliomas can potentially improve functioning through interdisciplinary rehabilitation.

  19. Using clinical and robotic assessment tools to examine the feasibility of pairing tDCS with upper extremity physical therapy in patients with stroke and TBI: a consideration-of-concept pilot study.

    Science.gov (United States)

    Middleton, Addie; Fritz, Stacy L; Liuzzo, Derek M; Newman-Norlund, Roger; Herter, Troy M

    2014-01-01

    Transcranial direct current stimulation (tDCS) may provide a safe, non-invasive technique for modulating neural excitability during neurorehabilitation. 1) Assess feasibility and potential effectiveness of tDCS as an adjunct to standard upper extremity (UE) physical therapy (PT) for motor impairments resulting from neurological insult. 2) Determine sustainability of improvements over a six month period. Five participants with chronic neurologic insult (stroke or traumatic brain injury > 6 months prior) completed 24 sessions (40 minutes, three times/week) of UE-PT combined with bihemispheric tDCS delivered at 1.5 mA over the motor cortex during the first 15 minutes of each PT session. Outcomes were assessed using clinical (UE Fugl-Meyer, Purdue Pegboard, Box and Block, Stroke Impact Scale) and robotic (unimanual and bimanual motor control) measures. Change in scores and associated effects sizes from Pre-test to Post-test and a six month Follow-up were calculated for each participant and group as a whole. Scores on UE Fugl-Meyer, Box and Block, Purdue Pegboard, Stroke Impact Scale, and robotic measures improved from Pre- to Post-test. Improvements on UE Fugl-Meyer, Box and Block, and robotic measures were largely sustained at six months. Combining bihemispheric tDCS with UE-PT in individuals with neurological insult warrants further investigation.

  20. Feasibility of intensive parent-child interaction therapy (I-PCIT): Results from an open trial

    Science.gov (United States)

    Graziano, Paulo A.; Bagner, Daniel M.; Slavec, Janine; Hungerford, Gabriela; Kent, Kristine; Babinski, Dara; Derefinko, Karen; Pasalich, Dave

    2014-01-01

    Objective The current pilot study examined the feasibility, acceptability, and initial outcome of an intensive and more condensed version of Parent-Child Interaction Therapy (90 minute sessions for 5 days/week over the course of 2 weeks). Method Using an open trial design, 11 children (M child age = 5.01 years) and their mothers completed a baseline period of 2 weeks, a treatment period of 2 weeks, and a post-treatment evaluation. A follow-up evaluation was also conducted 4 months following treatment completion. Across all assessments, mothers completed measures of child behavior and parenting stress, and observational data was collected during three 5-minute standard situations that vary in the degree of parental control (child-led play, parent-led play, & clean-up). Results All 11 families completed the intervention with extremely high attendance and reported high satisfaction. Results across both mother report and observations showed that: a) externalizing behavior problems were stable during the baseline period; b) treatment was effective in reducing externalizing behavior problems (ds = 1.67-2.50), improving parenting skills (ds = 1.93-6.04), and decreasing parenting stress (d = .91); and c) treatment gains were maintained at follow-up (ds = .53-3.50). Conclusions Overall, preliminary data suggest that a brief and intensive format of a parent-training intervention is a feasible and effective treatment for young children with externalizing behavior problems with clinical implications for improving children's behavioral impairment in a very brief period of time. PMID:26097286

  1. Sedimentary Geothermal Feasibility Study: October 2016

    Energy Technology Data Exchange (ETDEWEB)

    Augustine, Chad [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zerpa, Luis [Colorado School of Mines, Golden, CO (United States)

    2017-01-01

    The objective of this project is to analyze the feasibility of commercial geothermal projects using numerical reservoir simulation, considering a sedimentary reservoir with low permeability that requires productivity enhancement. A commercial thermal reservoir simulator (STARS, from Computer Modeling Group, CMG) is used in this work for numerical modeling. In the first stage of this project (FY14), a hypothetical numerical reservoir model was developed, and validated against an analytical solution. The following model parameters were considered to obtain an acceptable match between the numerical and analytical solutions: grid block size, time step and reservoir areal dimensions; the latter related to boundary effects on the numerical solution. Systematic model runs showed that insufficient grid sizing generates numerical dispersion that causes the numerical model to underestimate the thermal breakthrough time compared to the analytic model. As grid sizing is decreased, the model results converge on a solution. Likewise, insufficient reservoir model area introduces boundary effects in the numerical solution that cause the model results to differ from the analytical solution.

  2. Feasibility study of the AOSTA experimental campaign

    Directory of Open Access Journals (Sweden)

    Carta M.

    2016-01-01

    Full Text Available The reduction of the nuclear waste is one of the most important nuclear issues. The high radiotoxicity of the spent fuel is due to plutonium and some minor actinides (MAs such as neptunium, americium and curium, above all. One way to reduce their hazard is to destroy by fission MAs in appropriate nuclear reactors. To allow the MAs destruction an important effort have been done on the nuclear data due to the poor knowledge in this field. In the framework of one of the NEA Expert Group on Integral Experiments for Minor Actinide Management an analysis of the feasibility of MAs irradiation campaign in the TAPIRO fast research reactor is carried out. This paper provides preliminary results obtained by calculations modelling the irradiation, in different TAPIRO irradiation channels, of some CEA samples coming from the French experimental campaign OSMOSE, loaded with different contents of MAs, in order to access, through particular peak spectrometry, to their capture cross section. On the basis of neutron transport calculation results, obtained by both deterministic and Monte Carlo methods, an estimate of the irradiated samples counting levels from the AOSTA (Activation of OSMOSE Samples in TAPIRO experimental campaign is provided.

  3. Washoe Tribe Alternative Energy Feasibility Study Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jennifer [Washoe Tribe of NV and CA

    2014-10-01

    The Washoe Tribe of Nevada and California was awarded funding to complete the Washoe Tribe Alternative Energy Feasibility Study project. The main goal of the project was to complete an alternative energy feasibility study. This study was completed to evaluate “the potential for development of a variety of renewable energy projects and to conduct an alternative energy feasibility study that determines which alternative energy resources have the greatest economic opportunity for the Tribe, while respecting cultural and environmental values” (Baker-Tilly, 2014). The study concluded that distributed generation solar projects are the best option for renewable energy development and asset ownership for the Washoe Tribe. Concentrating solar projects, utility scale wind projects, geothermal, and biomass resource projects were also evaluated during the study and it was determined that these alternatives would not be feasible at this time.

  4. Mechanics Based Tomography: A Preliminary Feasibility Study

    Directory of Open Access Journals (Sweden)

    Yue Mei

    2017-05-01

    Full Text Available We present a non-destructive approach to sense inclusion objects embedded in a solid medium remotely from force sensors applied to the medium and boundary displacements that could be measured via a digital image correlation system using a set of cameras. We provide a rationale and strategy to uniquely identify the heterogeneous sample composition based on stiffness (here, shear modulus maps. The feasibility of this inversion scheme is tested with simulated experiments that could have clinical relevance in diagnostic imaging (e.g., tumor detection or could be applied to engineering materials. No assumptions are made on the shape or stiffness quantity of the inclusions. We observe that the novel inversion method using solely boundary displacements and force measurements performs well in recovering the heterogeneous material/tissue composition that consists of one and two stiff inclusions embedded in a softer background material. Furthermore, the target shear modulus value for the stiffer inclusion region is underestimated and the inclusion size is overestimated when incomplete boundary displacements on some part of the boundary are utilized. For displacements measured on the entire boundary, the shear modulus reconstruction improves significantly. Additionally, we observe that with increasing number of displacement data sets utilized in solving the inverse problem, the quality of the mapped shear moduli improves. We also analyze the sensitivity of the shear modulus maps on the noise level varied between 0.1% and 5% white Gaussian noise in the boundary displacements, force and corresponding displacement indentation. Finally, a sensitivity analysis of the recovered shear moduli to the depth, stiffness and the shape of the stiff inclusion is performed. We conclude that this approach has potential as a novel imaging modality and refer to it as Mechanics Based Tomography (MBT.

  5. Mechanics Based Tomography: A Preliminary Feasibility Study.

    Science.gov (United States)

    Mei, Yue; Wang, Sicheng; Shen, Xin; Rabke, Stephen; Goenezen, Sevan

    2017-05-09

    We present a non-destructive approach to sense inclusion objects embedded in a solid medium remotely from force sensors applied to the medium and boundary displacements that could be measured via a digital image correlation system using a set of cameras. We provide a rationale and strategy to uniquely identify the heterogeneous sample composition based on stiffness (here, shear modulus) maps. The feasibility of this inversion scheme is tested with simulated experiments that could have clinical relevance in diagnostic imaging (e.g., tumor detection) or could be applied to engineering materials. No assumptions are made on the shape or stiffness quantity of the inclusions. We observe that the novel inversion method using solely boundary displacements and force measurements performs well in recovering the heterogeneous material/tissue composition that consists of one and two stiff inclusions embedded in a softer background material. Furthermore, the target shear modulus value for the stiffer inclusion region is underestimated and the inclusion size is overestimated when incomplete boundary displacements on some part of the boundary are utilized. For displacements measured on the entire boundary, the shear modulus reconstruction improves significantly. Additionally, we observe that with increasing number of displacement data sets utilized in solving the inverse problem, the quality of the mapped shear moduli improves. We also analyze the sensitivity of the shear modulus maps on the noise level varied between 0.1% and 5% white Gaussian noise in the boundary displacements, force and corresponding displacement indentation. Finally, a sensitivity analysis of the recovered shear moduli to the depth, stiffness and the shape of the stiff inclusion is performed. We conclude that this approach has potential as a novel imaging modality and refer to it as Mechanics Based Tomography (MBT).

  6. Occupational Therapy in HomEcare Re-ablement Services (OTHERS): results of a feasibility randomised controlled trial.

    Science.gov (United States)

    Whitehead, Phillip J; Walker, Marion F; Parry, Ruth H; Latif, Zaid; McGeorge, Ian D; Drummond, Avril E R

    2016-08-16

    The objective of this study was to test the feasibility of conducting a randomised controlled trial (RCT) of an intervention targeted at activities of daily living (ADL), delivered by an occupational therapist, in homecare reablement. Feasibility parallel group RCT. Single-site local authority homecare reablement service. People referred for homecare reablement with ability to consent. Exclusion criteria were as follows: inability to speak English, receiving other community therapy services, needing two or more to assist transfer and receiving end-of-life care. 'Usual care' was 6 weeks of homecare reablement delivered by social care workers (no routine health professional input). A targeted ADL programme, delivered by an occupational therapist incorporating goal setting, teaching/practising techniques, equipment/adaptations and provision of advice/support. This was in addition to usual care. Aspects of feasibility including eligibility, recruitment, intervention delivery, attrition and suitability and sensitivity of outcome measures. Participant outcomes were personal and extended ADL, quality of life, falls and use of health and social care services. 30 participants were recruited, 15 to each arm, which was 60% of those eligible. Data from 22 (73%) were analysed at 6 months. Of the 15 participants, 13 (86%) received the intervention and were able to set one or more ADL goals. There were improvements from baseline in both groups, although overall improvements were greater in the occupational therapy (OT) intervention group. The biggest threat to feasibility was a change in service configuration during the trial, involving additional occupational therapy input, affecting usual care and recruitment. Despite the service reconfiguration, it was feasible to recruit and retain participants, deliver the intervention and collect outcome data that were responsive to change. The choice of primary outcome measure remains unclear. A further powered study is feasible and

  7. A feasibility study of bridge deck deicing using geothermal energy.

    Science.gov (United States)

    2015-04-01

    In this study, we investigated the feasibility of a ground-coupled system that utilizes heat energy harvested from the ground for : deicing of bridge decks. Heat exchange is performed using circulation loops integrated into the deep foundations suppo...

  8. Final Report: Feasibility Study of Biomass in Snohomish County, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Daryl Williams (Tulalip Tribes); Ray Clark (Clark Group)

    2005-01-31

    This report and its attachments summarizes the results of a unique tribal-farmer cooperative study to evaluate the feasibility of building one or more regional anaerobic digestion systems in Snohomish County, Washington.

  9. Ute Mountain Ute Tribe Community-Scale Solar Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Rapp, Jim [Parametrix; Knight, Tawnie [Ute Mountain Ute Tribe

    2014-01-30

    Parametrix Inc. conducted a feasibility study for the Ute Mountain Ute Tribe to determine whether or not a community-scale solar farm would be feasible for the community. The important part of the study was to find where the best fit for the solar farm could be. In the end, a 3MW community-scale solar farm was found best fit with the location of two hayfield sites.

  10. Bronchial fistula closure with negative pressure wound therapy: a feasible and cost-effective treatment.

    Science.gov (United States)

    Nunes, Rodrigo Barboza; Müller, Bruno Francisco; Cipriano, Federico Enrique Garcia; Coltro, Pedro Soler; Farina, Jayme Adriano

    2016-01-01

    Treatment of bronchial fistula (BF) after pulmonary lobectomy is a challenge. Often, patients require long hospital stay, have recurrent empyema and pneumonia, are susceptible to sepsis, often need broad-spectrum antibiotics, as well as various surgical approaches. With the advent and growing evidence of the benefits of negative pressure therapy (NPT), its use in some patients with BF has been reported with encouraging results concerning its feasibility and cost-effectiveness. The aim of this study was to demonstrate the application of NPT as a resource for BF treatment and comparatively analyze the overall cost of treatment. RESUMO O tratamento de fístula brônquica (FB) após lobectomia pulmonar é um desafio. Muitas vezes, o paciente demanda longo tempo de internação, apresenta recidivas de empiema e pneumonia, pode evoluir para sepse, frequentemente necessita de antibioticoterapia de amplo espectro, bem como de várias abordagens cirúrgicas. Com o advento e acúmulo de evidências dos benefícios da terapia por pressão negativa (TPN), seu uso em alguns pacientes com FB tem sido relatado com resultados animadores relativos à sua viabilidade e ao seu custo-efetividade. O objetivo deste estudo foi demonstrar a aplicação de TPN como recurso para tratamento da FB e analisar comparativamente o custo global do seu tratamento.

  11. A feasibility study comparing two chiropractic protocols in the treatment of patellofemoral pain syndrome.

    Science.gov (United States)

    Brantingham, James W; Globe, Gary A; Jensen, Muffit L; Cassa, Tammy K; Globe, Denise R; Price, Jennifer L; Mayer, Stephan N; Lee, Felix T

    2009-09-01

    The purpose of this pilot study was to determine the feasibility of (1) using the existing clinic, clinicians, interns, faculty, and staff from our college in conducting all components of a planned randomized controlled clinical trial; (2) successfully recruiting patients with patellofemoral pain syndrome (PFPS); and (3) consistently, effectively, and safely implementing the study protocols and therapy. Diagnostic, treatment, and blind assessment procedures were carried out while recruitment and administrative techniques for managing long-term storage of data and files were developed. Thirty-one patients were randomized into a local manipulative group (group A) or to a full kinetic chain manipulative therapy group (group B), each combined with exercise and soft tissue treatment. The Anterior Knee Pain Scale, visual analog scale, and Patient Satisfaction Scale were used. All phases of the feasibility study including use of the clinic, staff, recruitment techniques, treatment protocols, data collection, input, and analysis were effectively and safely carried out. A feasibility study investigating the ability to conduct a randomized controlled trial of a manipulative therapy protocol for PFPS using available chiropractic college infrastructure was accomplished. A fully powered PFPS trial is feasible and merited.

  12. Feasibility study of patient motion monitoring using tactile array sensor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Ho; Kang, Seong Hee; Kim, Dong Su; Cho, Min Seok; Kim, Kyeong Hyeon; Suh, Tae Suk [Dept. of Biomedical Engineering, Research Institute of Biomedical Engineering, the Catholic University of Korea, Seoul (Korea, Republic of); Kim, Si Yong [Dept. of Radiation Oncology, Virginia Commonwealth University, Richmond (United States)

    2014-11-15

    The aim of this study is to evaluate patient pretreatment set-up error and intra-fraction motion using the tactile array sensors (Pressure Profile Systems Inc, Los Angeles, CA) which could measure distributed pressure profiles along the contacting surface and to check a feasibility of the sensor (tactile array sensor) in the patient motion monitoring. Laser alignment and optical camera based monitoring system are very useful for reduce patient set-up error but these systems could not monitor the blind area like patient's back position. Actually after patient alignment using laser or optical monitoring system, it was assumed that there is no error in the patient's back position (pressure profile distribution). But if an error occurs in the patient's back position, it will affect the radiation therapy accuracy. In spite of optical motion monitoring or using the immobilization tool, distributed pressure profiles of patient's back position was changed during inter and intra-fraction. For more accurate patient set-up, blind area (patient's back) monitoring was necessary. We expect that the proposed method will be very useful for make up for the weakness of optical monitoring method.

  13. Feasibility Study for Battle Mountain Renewable Energy Park

    Energy Technology Data Exchange (ETDEWEB)

    Hill, Donna

    2014-09-30

    The Feasibility Study for the Battle Mountain Renewable Energy Park project (“Feasibility Study”) will assess the feasibility, benefits and impacts of a 5 Mega Watt (MW) solar photovoltaic (PV) generating system (the “Solar Project” or “Energy Park”) on the Te-Moak Tribe of Western Shoshone Indians of Nevada Battle Mountain Colony in Battle Mountain, Nevada (NV). The Energy Park will provide power for export to utility off-takers and job training and employment for Tribal members and revenue for the Tribe. This Feasibility Study will be a collaborative effort between the Tribal government, consultants, Tribal members and stakeholders and will allow the Tribe to make informed decisions regarding the Solar Project.

  14. Feasibility study: Assess the feasibility of siting a monitored retrievable storage facility. Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    King, J.W.

    1993-08-01

    The purpose of phase one of this study are: To understand the waste management system and a monitored retrievable storage facility; and to determine whether the applicant has real interest in pursuing the feasibility assessment process. Contents of this report are: Generating electric power; facts about exposure to radiation; handling storage, and transportation techniques; description of a proposed monitored retrievable storage facility; and benefits to be received by host jurisdiction.

  15. Remedial investigation/feasibility study badger army ammunition plant Baraboo, Wisconsin. Volume 1. Feasibility study report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-08-01

    This Feasibility Study (FS) report for the Badger Army Ammunition Plant (BAAP) in Baraboo, Wisconsin, was prepared by ABB Environmental Services, Inc. (ABB-ES) as a component of Task Order 1 of Contract DAAAl5-91-D-OOO8 with the U.S. Army Environmental Center (USAEC). This report uses the results presented in the Final Remedial Investigation (RI) report (ABB-ES, 1993a) to develop and screen alternatives for remediation of contaminated media at BAAP. The purpose of this FS report is to develop, screen, and evaluate site-specific remedial alternatives to mitigate the impact of site-derived chemicals and ultimately provide protection of human health and the environment. Preferred alternatives for each site are included in this report. Based on previous environmental studies at BAAP, 11 potential hazardous waste sites were ranked according to potential contributions of hazardous chemicals to the environment. These sites were designated as Waste Management Areas because some of the sites contain multiple Solid Waste Management Units (SWMUs). The sites selected to undergo facility assessment and corrective actions are: the Propellant Burning Ground (including Landfill), Deterrent Burning Ground, existing Landfill, Settling Ponds and Spoils Disposal Area, Rocket Paste Area, Oleum Plant and Oleum Plant Pond, Nitroglycerine Pond, old Acid Area, new Acid Area, and Ballistics Pond. The USAEC added an 11th site, the Old Fuel Oil Tank, to the list in October 1989 after discovery of fuel-contaminated soils during excavation of a water line in the vicinity of the old fuel oil tank foundation.

  16. Remedial investigation/feasibility study badger army ammunition plant Baraboo, Wisconsin. Volume 2. Feasibility study report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-08-01

    This Feasibility Study (FS) report for the Badger Army Ammunition Plant (BAAP) in Baraboo, Wisconsin, was prepared by ABB Environmental Services, Inc. (ABB-ES) as a component of Task Order 1 of Contract DAAAl5-91-D-OOO8 with the U.S. Army Environmental Center (USAEC). This report uses the results presented in the Final Remedial Investigation (RI) report (ABB-ES, 1993a) to develop and screen alternatives for remediation of contaminated media at BAAP. The purpose of this FS report is to develop, screen, and evaluate site-specific remedial alternatives to mitigate the impact of site-derived chemicals and ultimately provide protection of human health and the environment. Preferred alternatives for each site are included in this report. Based on previous environmental studies at BAAP, 11 potential hazardous waste sites were ranked according to potential contributions of hazardous chemicals to the environment. These sites were designated as Waste Management Areas because some of the sites contain multiple Solid Waste Management Units (SWMUs). The sites selected to undergo facility assessment and corrective actions are: the Propellant Burning Ground (including Landfill), Deterrent Burning Ground, existing Landfill, Settling Ponds and Spoils Disposal Area, Rocket Paste Area, Oleum Plant and Oleum Plant Pond, Nitroglycerine Pond, old Acid Area, new Acid Area, and Ballistics Pond. The USAEC added an 11th site, the Old Fuel Oil Tank, to the list in October 1989 after discovery of fuel-contaminated soils during excavation of a water line in the vicinity of the old fuel oil tank foundation.

  17. Verifying FreeRTOS; a feasibility study

    NARCIS (Netherlands)

    Pronk, C.

    2010-01-01

    This paper presents a study on modeling and verifying the kernel of Real-Time Operating Systems (RTOS). The study will show advances in formally verifying such an RTOS both by refinement and by model checking approaches. This work fits in the context of Hoare’s verification challenge. Several

  18. Starr Ranch Renewable Energy Feasibility Study

    Science.gov (United States)

    Starr Ranch Renewable Energy success story is the summary of a renewable energy study by U.S. EPA Region 6. This publication summarizes the analyses to determine appropriate renewable energy options in Starr Ranch.

  19. Wind Generation Feasibility Study in Bethel, AK

    Energy Technology Data Exchange (ETDEWEB)

    Tom Humphrey, YKHC; Lance Kincaid, EMCOR Energy & Technologies

    2004-07-31

    This report studies the wind resources in the Yukon-Kuskokwim Health Corporation (YKHC) region, located in southwestern Alaska, and the applicability of wind generation technologies to YKHC facilities.

  20. Verifying FreeRTOS; a feasibility study

    OpenAIRE

    Pronk, C.

    2010-01-01

    This paper presents a study on modeling and verifying the kernel of Real-Time Operating Systems (RTOS). The study will show advances in formally verifying such an RTOS both by refinement and by model checking approaches. This work fits in the context of Hoare’s verification challenge. Several real-time operating systems will be discussed including some commercial ones. The focus of the latter part of the paper will be on verifying FreeRTOS. The paper investigates a number of ways to verify th...

  1. Technical feasibility study of Voltage Optimization Unit

    DEFF Research Database (Denmark)

    Hu, Junjie; Marinelli, Mattia; Coppo, Massimiliano

    is performed using the soft-wares DigSilent PowerFactory and Matlab. In this simulation study, a real low voltage network from Dong Eldistribution is modeled in Powerfactory. The measured data of the real low voltage network is analyzed and the resulting loading profiles including active and reactive power...... are used as load basics for the analysis. In term of PV genera-tion profiles, a realistic PV output power is assumed. Four relevant indicies such as phase neutral voltage, netural potential voltage, unbalanced factor (VUF), and power losses are evaluated in the present study. The simulation tests include...

  2. World Languages and Cultures Feasibility Study

    Science.gov (United States)

    Sklarz, David P.

    2013-01-01

    The purpose of the study was to conduct a comprehensive review of the research and best practices of exemplary elementary school World Language and Culture Programs. Specifically, (1) to assess the degree to which various program designs had most closely met the measurable goals of the American Council of Teachers of a Foreign Language, commonly…

  3. Oral pressure therapy for treatment of obstructive sleep apnea: clinical feasibility

    Directory of Open Access Journals (Sweden)

    Farid-Moayer M

    2013-05-01

    Full Text Available Mehran Farid-Moayer,1 Lawrence C Siegel,2,3 Jed Black41Peninsula Sleep Center, Burlingame, CA, USA; 2Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA; 3Department of Clinical Affairs, ApniCure, Inc, Redwood City, CA, USA; 4Stanford Center for Sleep Research and Medicine, Stanford University School of Medicine, Stanford, CA, USAPurpose: This feasibility study examined the initial-use safety and effectiveness of a new noninvasive oral pressure therapy (OPT system developed to treat obstructive sleep apnea (OSA.Methods: The OPT system consists of a console that connects with flexible tubing to a premanufactured polymer mouthpiece. Through the mouthpiece, a pump in the console creates oral vacuum intended to move the soft palate anteriorly to decrease obstruction of the airway during sleep. The mouthpiece was produced in ten different sizes to accommodate a range of oral dimensions. Subjects with OSA in this single-center, single-night study underwent a polysomnography (PSG study at baseline, followed by PSG during use of OPT.Results: Fifty-six men and 20 women, aged 50.8 ± 12.0 years (mean ± standard deviation [SD], had OSA with apnea–hypopnea indices (AHI greater than five events per hour at baseline. Body weight averaged 98.0 ± 18.2 kg (mean ± SD, body mass index ranged from 22.6 kg/m2 to 57.9 kg/m2 and averaged 32.5 ± 5.8 kg/m2 (mean ± SD. OPT was generally well tolerated without any serious adverse events. Baseline AHI was 38.7 ± 27.5 events/hour (mean ± SD and was reduced with treatment to 24.6 ± 25.7 events/hour (P < 0.001, Cohen's d 0.53. Treatment produced AHI less than or equal to ten events/hour in 38% of the subjects. Oxygen desaturation index was 30.1 ± 23.7 events/hour at baseline versus 15.8 ± 19.1 events/hour with treatment (P < 0.001, Cohen's d 0.66. The minimum oxygen saturation increased with treatment from 77.9 ± 8.3 to 82.2 ± 7.9 (P < 0.001, Cohen's d 0.53. Stage-N1 sleep shifts

  4. Feasibility studies for GPD's measurement at COMPASS

    CERN Document Server

    Marroncle, J

    2004-01-01

    Deeply Virtual Compton Scattering is a clean way to access the Generalized Parton Distributions of the proton. This paper deals with a possibility to perform such an experiment with the COMPASS apparatus which allows to access a large rang in $x_{Bj}$(0.03 to 0.25) and $Q^{2}$(1.5 to 7.5 GeV$^{2}$). A possible design for a recoil detector which is necessary to complement the COMPASS setup, is presented. Preliminary results on exclusive $]rho^{0}$ production from the COMPASS 2002 run are given. They look promising for future studies of deep $\\rho^{0}$ production.

  5. Internet-delivered cognitive behavioural therapy for depression: a feasibility open trial for older adults.

    Science.gov (United States)

    Dear, Blake F; Zou, Judy; Titov, Nickolai; Lorian, Carolyn; Johnston, Luke; Spence, Jay; Anderson, Tracy; Sachdev, Perminder; Brodaty, Henry; Knight, Robert G

    2013-02-01

    Depression is an important health issue amongst older adults. Internet-delivered cognitive behaviour therapy (iCBT) may help to reduce barriers and improve access to treatment, but few studies have examined its use with older adults. The present study evaluated the efficacy, acceptability and feasibility of a brief iCBT program, the Managing Your Mood Program, to treat depression amongst adults aged 60 years and older. Using an open trial design, 20 participants with elevated symptoms of depression (Patient Health Questionnaire 9-item (PHQ-9) total scores ≥ 10) received access to five educational lessons and homework summaries, additional resources, a moderated discussion forum and weekly telephone or email contact from a clinical psychologist. Eighty percent of the sample met diagnostic criteria for a major depressive episode at pre-treatment. Completion rates and response rates were high, with 16/20 participants completing the five lessons within the 8 weeks, and post-treatment and 3-month follow-up data being collected from 17/20 participants. Participants improved significantly on the PHQ-9 and Geriatric Depression Scale (GDS), with large within-group effect sizes (Cohen's d) at follow-up of 1.41 and 2.04, respectively. The clinician spent a mean time of 73.75 minutes (SD = 36.10 minutes) contacting participants within the trial and the program was rated as highly acceptable by participants. The results are encouraging and support the potential value of iCBT in the treatment of depressive symptoms amongst older adults.

  6. High Falls Hydroelectric Plant feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Diezemann, Gustav A.

    1979-07-01

    This study was made in order to determine if re-activating the retired High Falls Hydro Station in New York would result in a more economical generation of some of the power required in the Central Hudson System than is being obtained with the oil-burning thermal plants. The findings show that the construction of a new plant is more economical than rehabilitation of the existing station. All new construction schemes are marginally unattractive at today's costs but are found to become profitable within a short period as alternative energy sources escalate in price. A new powerhouse with an installed capacity of 2390 kW proved most economical, and its construction is recommended.

  7. Feasibility study neutron diffraction at IRI

    Energy Technology Data Exchange (ETDEWEB)

    Haan, V.O. de

    1995-06-01

    Although neutron diffraction is a basic and relatively simple technique and should be available at a neutron source, it is not possible to perform neutron diffraction measurements at IRI at this moment. Until recently a neutron diffractometer with a relatively small flux at the sample position and a relaxed resolution (designed for liquid diffraction) was operated at IRI. Due to the modest neutron source intensity and the relatively old design (flat monochromator and single detector) this diffractometer was outdated. However, at a contemporary reactor source an instrument to perform neutron diffraction experiments cannot be missed. This study shows that thanks to recent developments in neutron diffraction optics it is possible to increase the flux, to enhance the resolution and to get a better flexibility. If also the number of detectors is increased or a position-sensitive detector is used to performance can be increased at least a thousand fold. A preliminary design is given to indicate how this gain can be realized. (orig.).

  8. CsIX/TRU Grout Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    S. J. Losinski; C. M. Barnes; B. K. Grover

    1998-11-01

    A settlement agreement between the Department of Energy (DOE) and the State of Idaho mandates that liquid waste now stored at the Idaho Nuclear Technology Engineering Center (INTEC - formerly the Idaho Chemical Processing Plant, ICPP) will be calcined by the end of year 2012. This study investigates an alternative treatment of the liquid waste that removes undissolved solids (UDS) by filtration and removes cesium by ion exchange followed by cement-based grouting of the remaining liquid into 55-gal drums. Operations are assumed to be from January 2008 through December 2012. The grouted waste will be contact-handled and will be shipped to the Waste Isolation Pilot Plant (WIPP) in New Mexico for disposal. The small volume of secondary wastes such as the filtered solids and cesium sorbent (resin) would remain in storage at the Idaho National Engineering and Environmental Laboratory for treatment and disposal under another project, with an option to dispose of the filtered solids as a r emote-handled waste at WIPP.

  9. Photon activated therapy (PAT using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

    Directory of Open Access Journals (Sweden)

    Choi Gi-Hwan

    2012-10-01

    Full Text Available Abstract Background X-rays are known to interact with metallic nanoparticles, producing photoelectric species as radiosensitizing effects, and have been exploited in vivo mainly with gold nanoparticles. The purpose of this study was to investigate the potential of sensitizing effect of iron oxide nanoparticles for photon activated therapy. Methods X-rays photon activated therapy (PAT was studied by treating CT26 tumor cells and CT26 tumor-bearing mice loaded with 13-nm diameter FeO NP, and irradiating them at 7.1 keV near the Fe K-edge using synchrotron x-rays radiation. Survival of cells was determined by MTT assay, and tumor regression assay was performed for in vivo model experiment. The results of PAT treated groups were compared with x-rays alone control groups. Results A more significant reduction in viability and damage was observed in the FeO NP-treated irradiated cells, compared to the radiation alone group (p Conclusions An iron oxide nanoparticle enhanced therapeutic effect with relatively low tissue concentration of iron and 10 Gy of monochromatic X-rays. Since 7.1 keV X-rays is attenuated very sharply in the tissue, FeO NP-PAT may have promise as a potent treatment option for superficial malignancies in the skin, like chest wall recurrence of breast cancer.

  10. Fidelity to a motivational interviewing intervention for those with post-stroke aphasia: A small scale feasibility study

    OpenAIRE

    Holland, Emma-Joy; Watkins, Caroline Leigh; Boaden, Elizabeth; Lightbody, Catherine Elizabeth

    2017-01-01

    Objective: Depression after stroke is common, and talk-based psychological therapies can be a useful intervention. Whilst a third of stroke survivors will experience communication difficulties impeding participation in talk-based therapies, little guidance exists to guide delivery for those with aphasia. We need to understand how to adapt talk-based therapies in the presence of aphasia. This study aimed to explore the feasibility of motivational interviewing (MI) in people with post-stroke ap...

  11. Feasibility of a Day-Camp Model of Modified Constraint-Induced Movement Therapy with and without Botulinum Toxin A Injection for Children with Hemiplegia

    Science.gov (United States)

    Eliasson, Ann-Christin; Shaw, Karin; Ponten, Eva; Boyd, Roslyn; Krumlinde-Sundholm, Lena

    2009-01-01

    The objective of the study was to investigate the feasibility of modified constraint-induced (CI) therapy provided in a 2-week day-camp model with and without intramuscular botulinum toxin type A (BoNT-A) injections for children with congenital cerebral palsy. Sixteen children with congenital hemiplegia, Manual Ability Classification System (MACS)…

  12. 75 FR 80827 - Compliance Policy Guide; Radiofrequency Identification Feasibility Studies and Pilot Programs for...

    Science.gov (United States)

    2010-12-23

    ...) Sec. 400.210 entitled ``Radiofrequency Identification (RFID) Feasibility Studies and Pilot Programs... ``Radiofrequency Identification (RFID) Feasibility Studies and Pilot Programs for Drugs.'' Previous extensions of...; Radiofrequency Identification Feasibility Studies and Pilot Programs for Drugs; Notice To Extend Expiration Date...

  13. The environmental energy sector programme. Poland: Feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    The Danish Ministry of Energy has granted financial aid to the preparation of a feasibility study necessary for the procurement of a financial solution to the modernisation of the combined heat and power plant in the city of Zielona Gora.The overall objectives of the Feasibility Study are to: establish new efficient power capacity in the south-west region of Poland, increase the energy efficiency, reduce the impact on the environment, utilise the local natural gas available which cannot be used in the national gas grid and reduce the costs of energy supply.The specific objective of this feasibility study is to obtain the best possible financing of the erection of a new CPH plant in Zielona Gora. The plant shall be designed to utilise the local resources of natural gas and to supply heat to the district heating grid in accordance with long-term planning strategies. (EHS)

  14. Measuring the actual I-131 thyroid uptake curve with a collar detector system: a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Brinks, Peter; Van Gils, Koen; Dickerscheid, Dennis B.M.; Habraken, Jan B.A. [Department of Medical Physics, St. Antonius Hospital, Nieuwegein (Netherlands); Kranenborg, Ellen; Lavalaye, Jules [Department of Nuclear Medicine, St. Antonius Hospital, Nieuwegein (Netherlands)

    2017-06-15

    Radionuclide therapy using I-131 is commonly used for the treatment of benign thyroid diseases. The therapeutic dose to be administered is calculated based on the type of disease, the volume of the thyroid, and the measured uptake percentage. This methodology assumes a similar biological half-life of iodine, whereas in reality a large variation in biological half-life is observed. More knowledge about the actual biological half-life of iodine for individual patients will improve the quantification of the delivered radiation dose during radioiodine therapy and could aid the evaluation of the success of the therapy. In this feasibility study we used a novel measurement device [Collar Therapy Indicator (CoTI)] to measure the uptake curve of patients undergoing I-131 radioiodine therapy. The CoTI device is a light-weight wearable device that contains two independent gamma radiation detectors that are placed in a collar. By comparing results of thyroid uptake measurements with results obtained with a gamma camera, the precision of the system is demonstrated. Additionally, for three patients the uptake curve is measured during 48 h of admission in the hospital. The presented results demonstrate the feasibility of the new measurement device to measure the uptake curve during radioiodine therapy. (orig.)

  15. Civil Engineering Feasibility Studies for Future Ring Colliders at CERN

    CERN Document Server

    Bruning, O; Myers, S; Osborne, J; Rossi, L; Waaijer, C; Zimmermann, F

    2013-01-01

    CERN civil engineers are studying the feasibility of several potential ring colliders to complement the LHC: an 80km circular tunnel to house the TLEP and VHE-LHC, and the ring-ring and linac-ring options for the LHeC. The feasibility of these projects is largely dependent on civil design and geotechnical and environmental risks. As civil infrastructure works typically represent one third of the cost of major physics projects, it is critical that the construction costs are well understood from the conceptual stage. This proceeding presents the first results of the feasibility studies for the 80km tunnel and the linac-ring LHeC. Presented at IPAC'13 Shanghai, 12-17 May 2013

  16. Reflection seismology systems for planetary geology : A feasibility study

    NARCIS (Netherlands)

    Batenburg, P.A.W.; Gill, E.K.A.; Drijkoningen, G.G.; Foing, B.H.; Toxopeus, G.

    2009-01-01

    A feasibility study is conducted to determine whether reflection seismology systems can be used for planetary geology research. The focus is on systems with up to 20,000 seismic detectors, such as used today in Earth geological research and energy companies. The study follows a top-down systems

  17. Transit Feasibility Study Guilford Courthouse National Military Park.

    Science.gov (United States)

    2009-02-28

    This study is intended to be a broad overview of the transit feasibility at Guilford Courthouse NMP. The study will discuss the project background and context, and outline the two options for transit service. A detailed evaluation of costs and benefi...

  18. MICROCRM: Feasibility certification studies of microbiological reference materials

    NARCIS (Netherlands)

    Mooijman KA; Nagelkerke NJD; Demarquilly C; Lemdani M; Stewardson D; Fouweather T; Lightfoot N; Simonart T; MGB

    2004-01-01

    In 2002 feasibility certification studies were carried out on three different types of microbiological reference materials for eight different ISO and EN standard methods, related to EU water legislation (Drinking-water Directive and Bathing-water Directive). These studies were performed as part of

  19. Organic Waste Diversion in Columbia, South Carolina, Feasibility Study

    Science.gov (United States)

    The study found that a variety of methods are technically and economically feasible for diverting food wastes and providing a positive return on investment for the source. Potential barriers and considerations for food waste diversion are identified in the study. Given the E...

  20. Balneotherapy Together with a Psychoeducation Program for Benzodiazepine Withdrawal: A Feasibility Study

    OpenAIRE

    P. De Maricourt; Gorwood, P.; Th. Hergueta; Galinowski, A.; Salamon, R; Diallo, A.; Vaugeois, C.; Lépine, J P; J. P. Olié; O. Dubois

    2016-01-01

    Benzodiazepines should be prescribed on a short-term basis, but a significant proportion of patients (%) use them for more than 6 months, constituting a serious public health issue. Indeed, few strategies are effective in helping patients to discontinue long-term benzodiazepine treatments. The aim of this study was to assess the feasibility and the impact of a program including cognitive behavioural therapy, psychoeducation, and balneotherapy in a spa resort to facilitate long-term discontinu...

  1. A Feasibility Study of Virtual Reality-Based Coping Skills Training for Nicotine Dependence.

    Science.gov (United States)

    Bordnick, Patrick S; Traylor, Amy C; Carter, Brian L; Graap, Ken M

    2012-05-01

    Virtual reality (VR)-based cue reactivity has been successfully used for the assessment of drug craving. Going beyond assessment of cue reactivity, a novel VR-based treatment approach for smoking cessation was developed and tested for feasibility. In a randomized experiment, 10-week treatment feasibility trial, 46 nicotine-dependent adults, completed the10-week program. Virtual reality skills training (VRST) combined with nicotine replacement therapy (NRT) was compared to NRT alone. Participants were assessed for smoking behavior and coping skills during, at end of treatment, and at posttreatment follow-up. Smoking rates and craving for nicotine were significantly lower for the VRST group compared to NRT-only group at the end of treatment. Self-confidence and coping skills were also significantly higher for the VRST group, and number of cigarettes smoked was significantly lower, compared to the control group at follow-up. Feasibility of VRST was supported in the current study.

  2. Acceptability and Feasibility of a Cell Phone Support Intervention for Youth Living with HIV with Nonadherence to Antiretroviral Therapy.

    Science.gov (United States)

    Belzer, Marvin E; Kolmodin MacDonell, Karen; Clark, Leslie F; Huang, Jennifer; Olson, Johanna; Kahana, Shoshana Y; Naar, Sylvie; Sarr, Moussa; Thornton, Sarah

    2015-06-01

    A pilot randomized clinical trial of youth ages 15-24 nonadherent to antiretroviral therapy (ART) utilizing daily cell phone support was found to have significant improvement in self-reported adherence and HIV RNA. Understanding acceptability and feasibility is critical for future implementation in clinic settings. Exit interviews were obtained from participants and adherence facilitators (AF). Acceptability was assessed from content analysis of exit interviews. Feasibility was assessed via intervention retention and study retention rates. Thirty-seven eligible youth were enrolled with 19 assigned to the intervention. Seven (37%) discontinued the intervention either due to missing over 20% of calls for two consecutive months (N=5) or missing 10 consecutive calls (N=2). Sixteen participants completed exit interviews, 15 reported the call length was just right, 13 reported they would have liked to continue calls after the 24-week intervention, and all participants reported they would recommend the intervention to friends. Scheduling and making calls required less than 1 h per week per participant. Providing cell phone support to youth nonadherent to ART was acceptable and feasible. While the cost is low compared to the price of ART, healthcare systems will need to explore how to cover the cost of providing cell phones (incentive).

  3. Exploring the feasibility and acceptability of a recovery-focused group therapy intervention for adults with bipolar disorder: trial protocol.

    Science.gov (United States)

    Beck, Alison K; Baker, Amanda; Jones, Steven; Lobban, Fiona; Kay-Lambkin, Frances; Attia, John; Banfield, Michelle

    2018-01-31

    Improving accessible, acceptable recovery-oriented service provision for people with bipolar disorder (BD) is an important priority. Mindfulness and acceptance-based cognitive and behavioural therapies (or 'third -wave' CBT) may prove fruitful due to the considerable overlap between these approaches and key features of personal recovery. Groups also confer therapeutic benefits consistent with personal recovery and may improve recovery-oriented service provision by adding another modality for accessing support. The primary objective of this trial is to explore the feasibility and acceptability of a new recovery-focused group therapy (RfGT) intervention for adults with BD. This is the first published feasibility assessment of a time-limited RfGTrecovery-focused group therapy intervention for BD. This protocol describes an open feasibility study, utilising a pre-treatment design versus post- treatment design and nested qualitative evaluation. Participants will be recruited from the Central Coast region of New South Wales, Australia, from primary care providers, specialist mental health services, non-government organisations and via self-referral. The primary outcomes are feasibility and acceptability as indexed by recruitment, retention, intervention adherence, adverse events (if any) and detailed consumer feedback. Clinical outcomes and process measures will be assessed to inform future research. Primary outcome data will utiliseuse descriptive statistics (eg, summarizingsummarising recruitment, demographics, attendance, attrition and intervention adherence). Secondary outcomes will be assessed using repeated-measures analysis of covariance across all time points (including change, effect size and variability). Ethical approval has been granted by the Northern Sydney Local Health District HREChuman research ethics committee (HREC) (HREC/16/HAWKE/69) and The University of Newcastle HREC (H-2016-0107). The Ffindings will be used to improve the intervention per user

  4. Feasibility of Breast Conserving Surgery in Stage IIIA Breast Carcinoma Patients in the Absence of Neoadjuvant Therapy

    Directory of Open Access Journals (Sweden)

    Abeer Ibrahim

    2015-07-01

    Full Text Available Background: Preoperative determination of the extent of viable residual tumor is an important issue after neoadjuvant treatment. On the other hand, retrospective data suggest that breast-conserving surgery is feasible up to stage IIIA breast cancer without preoperative therapy. Methods: We retrospectively analyzed 164 patients who underwent breastconserving surgery followed by adjuvant chemotherapy and/or endocrinal therapy with whole breast radiation between 2005 and 2012. Of those, 116 patients had stages I and II (group 1 breast cancer, whereas 48 patients had stage IIIA (group 2. Results:After a median follow-up of 40.4 months, 18 (15.5% patients in group- 1and 8 (16.6% in group-2 developed ipsilateral breast tumor recurrence (P=0.77. Mean time to tumor recurrence was 19 months in group 1 and 17 months in group 2 (P=0.5. However we found more ipsilateral breast tumor recurrence in hormone negative tumors (P=0.002, high grade tumors (P=0.021, young age (P=0.017 and lymph node positive cases (P=0.011. We observed no significant difference between N1 and N2 lymph node status (P=0.241. Conclusion: Our data suggest that breast-conserving surgery with R0 resection is feasible in stage IIIA cases whenever cosmetic appearance can be maintained as long as surgery will be followed by radiotherapy and chemotherapy. A prospective study with larger numbers is recommended for further evaluation of this issue.

  5. Front Range Forest Health Partnership Phase 1 feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Volkin, P

    1998-09-01

    The Front Range Forest Health Partnership is an alliance of individuals, citizen groups, federal, state, private, and nonprofit organizations that formed to promote forest health restoration and reduce fire risks on Colorado's Front Range. The partnership promotes selective thinning to restore forest health and supports economically feasible end uses for wood waste materials. The Phase I study was initiated to determine the environmental and economic feasibility of using wood wastes from forested and urban areas for the production of fuel-grade ethanol.

  6. Feasibility Study of the Social Enterprise Intervention with Homeless Youth

    Science.gov (United States)

    Ferguson, Kristin M.; Xie, Bin

    2008-01-01

    Objective: To reduce mental health symptoms and high-risk behaviors and increase social support and service utilization among street-living youth, the authors conducted a pilot study to assess the feasibility of the social enterprise intervention (SEI) at a homeless youth agency. Method: Convenience sampling was used to recruit 16 street-living…

  7. The environmental energy sector programme. Poland: Appendices to feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    The appendices contain Energy Law, Act of 10 April 1997 and also more specific details from the feasibility study for the procurement of a financial solution to the modernisation of the combined heat and power plant in the city of Zielona Gora, Poland. (EHS)

  8. Hadoop for EEG Storage and Processing: A Feasibility Study

    NARCIS (Netherlands)

    Berrada, Ghita; van Keulen, Maurice; Habib, Mena Badieh; Slezak, Dominik; Tan, Ah-Hwee; Peters, James F.; Schwabe, Lars

    Lots of heterogeneous complex data are collected for diagnosis purposes. Such data should be shared between all caregivers and, often at least partly automatically processed, due to its complexity, for its full potential to be harnessed. This paper is a feasibility study that assesses the potential

  9. Embedding Resilience within the Tertiary Curriculum: A Feasibility Study

    Science.gov (United States)

    Stallman, Helen M.

    2011-01-01

    Mental health problems can significantly impact on the ability of university students to both meet their individual potential and contribute positively within society. This study evaluates the feasibility of embedding a strength-focused resilience-building seminar within a university curriculum. Participants were 247 students enrolled in an…

  10. Vessel electrification feasibility study for the New York state canals.

    Science.gov (United States)

    2013-10-01

    The objective of this study was to determine the technical and economic feasibility of repowering a diesel-fueled : New York State Canal Corporation (NYSCC) work boat with a diesel hybrid-electric or full-electric powertrain. : The project team instr...

  11. Distance Learning Enrollments in Independent Institutions. Feasibility Study.

    Science.gov (United States)

    Washington State Higher Education Coordinating Board, Olympia.

    This study investigated the feasibility of collecting enrollment data on distance learning programs sponsored by private institutions within and outside of Washington State. E-commerce developments have allowed in-state independent providers and out-of-state public institutions to serve residents of Washington State, and many nontraditional…

  12. Staging and storage facility feasibility study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Swenson, C.E. [Westinghouse Hanford Co., Richland, WA (United States)

    1995-02-01

    This study was performed to investigate the feasibility of adapting the design of the HWVP Canister Storage Building (CSB) to meet the needs of the WHC Spent Nuclear Fuel Project for Staging and Storage Facility (SSF), and to develop Rough Order of Magnitude (ROM) cost and schedule estimates.

  13. British Columbia Library Network: A Study of Feasibility. Revised.

    Science.gov (United States)

    Shoffner, Ralph M.; Madden, Mary A.

    This feasibility study was conducted to collect financial, operational, and other data concerning the alternatives of continuing with the University of Toronto Library Automation System (UTLAS), the present supplier of catalog support to the British Columbia Union Catalogue (BCUC) participating libraries, or of replicating the Washington Library…

  14. Study Model on the Feasibility of Adopting Telework

    Directory of Open Access Journals (Sweden)

    Bogdan GHILIC-MICU

    2006-01-01

    Full Text Available The following considerations present a possible work model for the study of feasibility of adopting telework and present a systematic approach for the purpose of telework opportunity evaluation by the managers. The main objective is to develop a conceptual framework and a decision support system for the managers responsible with implementing telework within their own organizations.

  15. Exercise for Adolescents with Depressive Disorders: A Feasibility Study

    OpenAIRE

    Dopp, Richard R.; Mooney, Ann J.; Roseanne Armitage; Cheryl King

    2012-01-01

    Objectives. Adolescence is associated with increased depressive symptoms and decreased aerobic exercise, yet the relationship between exercise and clinical depression among adolescents requires further examination. This study assessed the feasibility of a 12-week intervention designed to increase exercise for adolescents with depressive disorders: Will a teenager with depression exercise? Methods. Participants were 13 adolescents with depression reporting low levels of aerobic exercise. They ...

  16. Small modular biopower initiative Phase 1 feasibility studies executive summaries

    Energy Technology Data Exchange (ETDEWEB)

    Bain, R.

    2000-03-06

    The Phase 1 objective is a feasibility study that includes a market assessment, resource assessment, preliminary system design, and assessment of relevant environmental and safety considerations, and evaluation of financial and cost issues, and a preliminary business plan and commercialization strategy. Each participating company will share at least 20% of the cost of the first phase.

  17. Final Technical Report: Renewable Energy Feasibility Study and Resources Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Mariah [BEC Environmental, Inc., Las Vegas, NV (United States)

    2016-02-28

    In March 2011, the U.S. Department of Energy (DOE) awarded White Pine County, Nevada, a grant to assess the feasibility of renewable resource-related economic development activities in the area. The grant project included a public outreach and training component and was to include a demonstration project; however, the demonstration project was not completed due to lack of identification of an entity willing to locate a project in White Pine County. White Pine County completed the assessment of renewable resources and a feasibility study on the potential for a renewable energy-focused economic sector within the County. The feasibility study concluded "all resources studied were present and in sufficient quantity and quality to warrant consideration for development" and there were varying degrees of potential economic impact based on the resource type and project size. The feasibility study and its components were to be used as tools to attract potential developers and other business ventures to the local market. White Pine County also marketed the County’s resources to the renewable energy business community in an effort to develop contracts for demonstration projects. The County also worked to develop partnerships with local educational institutions, including the White Pine County School District, conducted outreach and training for the local community.

  18. Feasibility study on small modular reactors for modern microgrids

    Energy Technology Data Exchange (ETDEWEB)

    Islam, R.; Gabbar, H.A., E-mail: hossam.gabbar@uoit.ca [Univ. of Ontario Inst. of Technology, Faculty of Energy Systems and Nuclear Science, Oshawa, Ontario (Canada)

    2013-07-01

    Microgrid is a solution of conventional power grid problem and offer sustainable decentralized power system. Microgrid with modern distributed energy resources (DER) could play an important role to alleviate dependency on the main electricity grid. Distributed energy resource comprises wind turbine, solar photovoltaic, diesel generator, gas engine, micro turbine, fuel cells, etc.Due to the gap between typical loads and supply within microgrid, larger scale energy generation could provide a possible solution to balance power demand and supply. Feasibility study of Small Nuclear Power Plant, such as Small Modular reactor (SMR), within microgrids could be achieved via different cases. To achieve the target, a comprehensive feasibility study is conducted on microgrid with SMR through electricity generation profiles, geographical and environmental assessment, as well as cost analysis using simulation practices and data analysis.Also potency of SMRs is analyzed. Parameters and Key Performance Indicators (KPIs) could be analyzed to achieve feasible solution of microgrids with small modular reactor (SMR) to improve the overall microgrid performance.The study shows that SMR could be a feasible solution if microgrid parameters are selected properly. (author)

  19. Minimally invasive local ablative therapies in combination with radioiodine therapy in benign thyroid disease: preparation, feasibility and efficiency - preliminary results.

    Science.gov (United States)

    Mader, Alexander; Mader, Oscar Maximilian; Gröner, Daniel; Korkusuz, Yücel; Ahmad, Shadi; Grünwald, Frank; Kranert, W Tilman; Happel, Christian

    2017-12-01

    Initial studies of combinations of radioiodine therapy (RIT) and local ablative procedures for the treatment of thyroid nodules have shown promising results. The goal of this study was to evaluate the effectiveness of RIT combined with radiofrequency ablation (RFA) in patients with goitres and to determine which ablative procedure is the most suitable for a combined therapy. Thirty patients with goitres were divided into two subgroups. A test group of 15 patients received combined therapy (RIT + RFA) and a control group of 15 patients received RIT mono therapy. All patients underwent assessments including ultrasound, laboratory evaluation (T3, T4, TSH, TG, TPOAb, TgAbTRAb) and scintigraphic imaging with Tc-99m-Pertechnetate. The 3-month volume reduction was used to evaluate therapy effectiveness. Combined therapy (subgroup 1) resulted in a significant (p  0.05) than the control group (20.2 ± 32.2 ml/29.6 ± 42.1%). All patients became euthyroid after treatment. No major discomfort or complications occurred. A review of the literature investigating combinations of other local ablative procedures with RIT was performed to determine the most promising combination. The present study confirms the positive experiences with the combined therapy of RIT and local ablative procedures shown in the current literature and approves this approach for the treatment of goitres with RFA + RIT. These findings, when confirmed by further studies, should expand the indication of combined therapy as a minimally invasive alternative to surgery.

  20. Feasibility, acceptability and potential effectiveness of Dignity Therapy for older people in care homes: a phase II randomized controlled trial of a brief palliative care psychotherapy.

    Science.gov (United States)

    Hall, Sue; Goddard, Cassie; Opio, Diana; Speck, Peter; Higginson, Irene J

    2012-07-01

    A pilot study of Dignity Therapy conducted with hospice patients reported high levels of self-reported benefits of the psychotherapy. To assess the feasibility, acceptability and potential effectiveness of Dignity Therapy to reduce distress in older people in care homes. A randomized controlled open-label trial (ISRCTN37589515). 60 residents aged 65+ with no major cognitive impairment living in care homes in London, UK. Dignity Therapy, a brief palliative care psychotherapy. Potential effectiveness (dignity-related distress, depression, hopefulness, quality of life at baseline and 1 and 8-week follow-up); acceptability (residents' views on self-reported benefits of Dignity Therapy/the Dignity Therapy study); and feasibility (time taken to deliver the intervention). We randomized 60/755 (8%) residents: 29 - control, 31 - intervention. We found no significant differences between groups on measures of potential effectiveness at any time. There was a reduction in dignity-related distress across both groups (p = 0.026). The intervention group outperformed the control group on all the acceptability items at both follow-ups. Effect sizes (Cohen's d) ranged from small (0.25) to large (0.85). These were significant for feeling that Dignity Therapy/the Dignity Therapy study had made their life more meaningful at 2-week follow-up (p = 0.04), and that it would help their families at both follow-ups (p = 0.02 and p = 0.01, respectively). Although it was feasible to deliver the intervention in this setting, it took longer to complete than anticipated. Although Dignity Therapy took longer to deliver than expected, this intervention may be a way of enhancing the end-of-life experiences of residents.

  1. Feasibility study on production of Co-60 in PHWR

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kyung Bae; Han, Hyon Soo; Joo, Po Kook

    2000-05-01

    The purpose of this study is to analyze the safeties and the economics for Co-60 production from Wolsung PHWR and to verify the feasibility on the manufacturing of the final Co-60 source for industrial irradiation. The feasibility of reactor conversion was carried out with KEPCO collaboration. Through the site survey on the experience of Gentililly-2 in Canada, a feasibility of plant conversion, changes in design, equipment and tools for Co-60 production was verified. It was estimated that the reactor conversion would not impose adverse impact on plant safety. For the encapsulation of radiation source and storage of the final products, a modification of concrete hot cell at KAERI was primary concerns. The installation and improvement of facilities are needed to avoid cross contamination and extra radiation exposure. Main items for these are pressure gauge, separated HEPA filter the ceiling separation, extra-shielding and ceiling hoist system. At present, storage pool has got admission based on 400 kCi. But it is necessary to seismic analysis and design improvement of shielding to store 10 MCi (Co-60) which is the estimated Co-60 capacity produced by 3 PHWRs. According to present investigation, a production of Co-60 by PHWR and RIPE was seemed to be an economically feasible business and it was also expected that a joint venture will be able to realize by cooperation with MDS Nordion Co.

  2. Feasibility study of combined heating and cooling by biomass

    OpenAIRE

    Chopo Puertollano, Miguel

    2011-01-01

    PFC del programa Erasmus EPS elaborat a Jyväskylan Ammattikorkeakoulu The main objective was to show the feasibility of biomass in order to produce combined heating and cooling. The energy study of the European heat market and the policy of energy, aims to demonstrate the meaning of the study. Furthermore, the weather in Catalonia is confirming the interest for the topic. Biomass is a renewable energy and this implies a considerable reduction of the pollution. The technical and economical ...

  3. Feasibility studies of the diffractive bremsstrahlung measurement at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Chwastowski, Janusz J.; Czekierda, Sabina; Staszewski, Rafal; Turnau, Jacek; Trzebinski, Maciej [The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Cracow (Poland); Kycia, Radoslaw [Cracow University of Technology, Faculty of Physics, Mathematics and Computer Science, Cracow (Poland)

    2016-06-15

    Feasibility studies of an observation of the exclusive diffractive bremsstrahlung in proton-proton scattering at the centre of mass energy 13 TeV at the LHC are reported. These studies aim at the dedicated data taking periods with low instantaneous luminosity delivered by the LHC where the pile-up interactions can be neglected. A simplified approach to the photon and the scattered proton energy reconstruction is used. The background influence is discussed. (orig.)

  4. Encoal mild coal gasification project: Commercial plant feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    In order to determine the viability of any Liquids from Coal (LFC) commercial venture, TEK-KOL and its partner, Mitsubishi Heavy Industries (MHI), have put together a technical and economic feasibility study for a commercial-size LFC Plant located at Zeigler Coal Holding Company`s North Rochelle Mine site. This resulting document, the ENCOAL Mild Coal Gasification Plant: Commercial Plant Feasibility Study, includes basic plant design, capital estimates, market assessment for coproducts, operating cost assessments, and overall financial evaluation for a generic Powder River Basin based plant. This document and format closely resembles a typical Phase II study as assembled by the TEK-KOL Partnership to evaluate potential sites for LFC commercial facilities around the world.

  5. Internet-based cognitive behavioral therapy for depression and anxiety in Parkinson's disease — A pilot study

    National Research Council Canada - National Science Library

    Kraepelien, Martin; Svenningsson, Per; Lindefors, Nils; Kaldo, Viktor

    2015-01-01

    .... The availability of evidence-based psychological interventions is low. Objective: This pilot study investigates the feasibility and preliminary effect of internet-based cognitive behavioral therapy (ICBT...

  6. Cogeneration feasibility study in the Gulf States Utilities service area

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    Sites in the Gulf States Utilities service are considered for cogeneration feasibility studies. The sources of steam considered for the Orange, Texas and Geismar, Lake Charles, and North Baton Rouge, Louisiana sites include oil, coal, HTGR steamers, consolidated nuclear steam system, atmospheric fluidized-bed coal combustion, and coal gasification. Concepts concerning cogeneration fuel systems were categorized by technical applicability as: current technology (pulverized coal-fired boilers and fuel oil-fired boilers), advanced technology under development (HTGR steamers and the CNSS), and advanced technology for future development (atmospheric fluidized-bed boilers and coal gasification). In addition to providing data on cogeneration plant generally useful in the US, the study determined the technical and economic feasibility of steam and electric power cogeneration using coal and nuclear fuels for localized industrial complexes. Details on site selection, plant descriptions, cost estimates, economic analysis, and plant schedule and implementation. (MCW)

  7. Technical Feasibility Study for Zero Energy K-12 Schools

    Energy Technology Data Exchange (ETDEWEB)

    Bonnema, Eric [National Renewable Energy Lab. (NREL), Golden, CO (United States); Goldwasser, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Torcellini, Paul [National Renewable Energy Lab. (NREL), Golden, CO (United States); Pless, Shanti [National Renewable Energy Lab. (NREL), Golden, CO (United States); Studer, Daniel [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-11-01

    This technical feasibility study provides documentation and research results supporting a possible set of strategies to achieve source zero energy K-12 school buildings as defined by the U.S. Department of Energy (DOE) zero energy building (ZEB) definition (DOE 2015a). Under this definition, a ZEB is an energy-efficient building in which, on a source energy basis, the actual annual delivered energy is less than or equal to the on-site renewable exported energy.

  8. Coeur d'Alene Tribe Energy Efficiency Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Allgood, Tiffany L. [Coeur d' Alene Tribe, Plummer, ID (United States); Sorter, Andy [Coeur d' Alene Tribe, Plummer, ID (United States)

    2014-09-01

    The Coeur d'Alene Tribe's Energy Efficiency Feasibility Study (EEFS) is the culminating document that compiles the energy efficiency and building performance assessment and project prioritization process completed on 36 Tribally owned and operated facilities within Tribal lands. The EEFS contains sections on initial findings, utility billing analyses, energy conservation measures and prioritization and funding sources and strategies for energy project implementation.

  9. Patient-specific academic detailing for smoking cessation: feasibility study.

    Science.gov (United States)

    Jin, Margaret; Gagnon, Antony; Levine, Mitchell; Thabane, Lehana; Rodriguez, Christine; Dolovich, Lisa

    2014-01-01

    To describe and to determine the feasibility of a patient-specific academic detailing (PAD) smoking cessation (SC) program in a primary care setting. Descriptive cohort feasibility study. Hamilton, Ont. Pharmacists, physicians, nurse practitioners, and their patients. Integrated pharmacists received basic academic detailing training and education on SC and then delivered PAD to prescribers using structured verbal education and written materials. Data were collected using structured forms. Five main feasibility criteria were generated based on Canadian academic detailing programs: PAD coordinator time to train pharmacists less than 40 hours; median time of SC education per pharmacist less than 20 hours; median time per PAD session less than 60 minutes for initial visit; percentage of prescribers receiving PAD within 3 months greater than 50%; and number of new SC referrals to pharmacists at 6 months more than 10 patients per 1.0 full-time equivalent (FTE) pharmacist (total of approximately 30 patients). Eight pharmacists (5.8 FTE) received basic academic detailing training and education on SC PAD. Forty-eight physicians and 9 nurse practitioners consented to participate in the study. The mean PAD coordinator training time was 29.1 hours. The median time for SC education was 3.1 hours. The median times for PAD sessions were 15 and 25 minutes for an initial visit and follow-up visit, respectively. The numbers of prescribers who had received PAD at 3 and 6 months were 50 of 64 (78.1%) and 57 of 64 (89.1%), respectively. The numbers of new SC referrals at 3 and 6 months were 11 patients per FTE pharmacist (total of 66 patients) and 34 patients per FTE pharmacist (total of 200 patients), respectively. This study met the predetermined feasibility criteria with respect to the management, resources, process, and scientific components. Further study is warranted to determine whether PAD is more effective than conventional academic detailing.

  10. Acceptability and feasibility of a virtual intervention to help people living with HIV manage their daily therapies.

    Science.gov (United States)

    Côté, José; Rouleau, Geneviève; Godin, Gaston; Ramirez-Garcìa, Pilar; Guéhéneuc, Yann-Gaël; Nahas, Georgette; Tremblay, Cécile; Otis, Joanne; Hernandez, Annick

    2012-10-01

    We conducted a study of the acceptability and feasibility of a web application which was designed to empower people living with HIV to manage their daily antiretroviral therapies. The application (VIH-TAVIE) consists of four interactive computer sessions with a virtual nurse who guides the user through a learning process aimed at enhancing treatment management capacities. The information furnished and the strategies proposed by the nurse are tailored, based on the responses provided by the user. The application was evaluated in a hospital setting as an adjunct to usual care. The participants (n = 71) had a mean age of 47 years (SD = 7.6). There were 59 men and 12 women. They had been diagnosed with HIV some 15 years earlier and had been on antiretroviral medication for a mean duration of 11 years. Data were collected by acceptability questionnaires, field notes and observations. Most participants found the application easy to use. They learned tips for taking their medication, diminishing adverse side-effects and maintaining a positive attitude towards treatment. Many participants deemed their experience with the application highly satisfactory and felt that it met their needs with respect to strategies and proficiencies despite their long experience of medication use. The results of the study support the feasibility and acceptability of the intervention.

  11. Elastography using harmonic ultrasonic imaging: a feasibility study.

    Science.gov (United States)

    Desai, Raghavendra Reddy; Krouskop, Thomas A; Righetti, Raffaella

    2010-04-01

    Tissue Harmonic Imaging (THI) is a relatively new modality that has had a significant impact in the ultrasound field. In the recent past, imaging the mechanical properties of tissues using elastography has also gained great interest. In this paper, we investigate the feasibility of combining these two state-of-the-art ultrasound-imaging modalities. The performance of elastograms obtained using harmonic ultrasonic signals is studied with simulations and compared to the performance of conventional elastograms using standard statistical methods. Experiments are used as a proof of the technical feasibility of generating tissue-harmonic elastograms using experimental harmonic signals. The results of our simulation study indicate that all image quality factors considered in this study (elastographic signal-to-noise ratio, elastographic contrast-to-noise ratio and spatial resolution) may be improved when using harmonic ultrasonic signals, provided that the ultrasound system is characterized by high bandwidth, high sampling frequency and large lateral sampling. Preliminary experimental results suggest that it is technically feasible to generate experimental elastograms using harmonic signals, provided that the sonographic signal-to-noise ratio of the pre- and postcompression harmonic frames is sufficiently high to guarantee reliable values of correlation.

  12. Feasibility Study for a Hopi Utility-Scale Wind Project

    Energy Technology Data Exchange (ETDEWEB)

    Kendrick Lomayestewa

    2011-05-31

    The goal of this project was to investigate the feasibility for the generation of energy from wind and to parallel this work with the development of a tribal utility organization capable of undertaking potential joint ventures in utility businesses and projects on the Hopi reservation. The goal of this project was to investigate the feasibility for the generation of energy from wind and to parallel this work with the development of a tribal utility organization capable of undertaking potential joint ventures in utility businesses and projects on the Hopi reservation. Wind resource assessments were conducted at two study sites on Hopi fee simple lands located south of the city of Winslow. Reports from the study were recently completed and have not been compared to any existing historical wind data nor have they been processed under any wind assessment models to determine the output performance and the project economics of turbines at the wind study sites. Ongoing analysis of the wind data and project modeling will determine the feasibility of a tribal utility-scale wind energy generation.

  13. A Postpartum Sleep and Fatigue Intervention Feasibility Pilot Study.

    Science.gov (United States)

    Doering, Jennifer J; Dogan, Sirin

    2018-01-01

    The purpose of this pilot study was to evaluate the feasibility, acceptability, and cost of a self-management intervention for postpartum fatigue and sleep in socioeconomically disadvantaged urban women. Helping U Get Sleep (HUGS) is a theory-guided intervention developed from the Individual and Family Self-Management Theory. Medicaid-enrolled participants in the United States were recruited from an inpatient postpartum unit. Treatment and attention control interventions were delivered (15 HUGS, 12 comparison) at a week 3 postpartum home visit and 4 follow-up phone calls. Over the 9-week protocol, the HUGS group demonstrated significant improvements in subjective fatigue and subjective sleep disturbance relative to the comparison group. The HUGS intervention was feasible and acceptable, delivered on average, in 100 min and costing US$79 per participant.

  14. Market assessment and technical feasibility study of PFBC ash use

    Energy Technology Data Exchange (ETDEWEB)

    Smith, V.E.; Bland, A.E.; Brown, T.H. [Western Research Inst., Laramie, WY (United States); Georgiou, D.N. [Jacques, Whitford and Associates Ltd., Dartmouth, NS (Canada); Wheeldon, J. [Electric Power Research Inst., Palo Alto, CA (United States)

    1994-10-01

    The overall objectives of this study are to determine the market potential and the technical feasibility of using PFBC ash in high volume ash use applications. The information will be of direct use to the utility industry in assessing the economics of PFBC power generation in light of ash disposal avoidance through ash marketing. In addition, the research is expected to result in the generation of generic data on the use of PFBC ash that could lead to novel processing options and procedures. The specific objectives of the proposed research and demonstration effort are: Define resent and future market potential of PFBC ash for a range of applications (Phase I); assess the technical feasibility of PFBC ash use in construction, civil engineering and agricultural applications (Phase II); and demonstrate the most promising of the market and ash use options in full-scale field demonstrations (Phase III).

  15. Feasibility study to steam injection in a naturally fractured reservoir

    Energy Technology Data Exchange (ETDEWEB)

    Meza P, Edgar; Garcia H, Francisco; Sanchez D, Rebeca; Urzua H, Jose [PEMEX - Petroleos Mexicanos, Mexico D.F. (Mexico)

    2008-07-01

    This work contains the advance in several activities to make the feasibility analysis to steam injection in naturally fractured reservoir. The study includes one methodology to implant an additional recovery process, make a check of the variables involve in selection process and reproduction in a numerical model of the analytical simulation of cyclic steam injection to make a sensitivity analysis of some operational variables. This paper presents specialized graphs to evaluate the feasibility of the steam injection according to the criteria described in the world. The simulation process includes a single well model with average properties and general thermal characteristics because the reservoir does not have these laboratory tests. The variables of sensitivity analysis were quality of injected steam, time of injection, time of soaking, injection rate and production rate. We show results of sensitivity analysis and numerical simulation of the process of cyclic steam injection. (author)

  16. Long term cryogen storage in space - A feasibility study

    Science.gov (United States)

    Kittel, P.; Parmley, R. T.

    The conduction of future space missions will require the long term storage of cryogens in space. Such missions will be performed in connection with the employment of the long life version of the Shuttle Infrared Telescope Facility (SIRTF), the Large Deployable Reflector (LDR), Gravity Probe B (GPB), Orbital Transfer Vehicles (OTVs), and the Space Station. The feasibility of building a long lifetime helium Dewar for space applications has been studied. A feasible concept was to be developed for a Shuttle-launchable 3-yr lifetime Dewar. The developed concept was to be used for the identification of key technology development areas. The desired long lifetime requires the minimization of the parasitic heat loads. It has been found that the majority of the parasitic heat load can be provided by the fiberglass-epoxy tension band supports. A new type of support system, the Passive Orbital Disconnect Strut (PODS), was developed to reduce the considered contribution to the heat load.

  17. PUEBLO OF ZIA RENEWABLE ENERGY DEVELOPMENT FEASIBILITY STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Pino, Peter M. [Tribal Administrator (Ret.), Pueblo of Zia; Lakshman, Jai [Project Manager (NDA) for Pueblo of Zia; Toole, G. Loren [Principal Investigator, Los Alamos National Laboratory - Energy Analysis Team/ CCS-3, D-4; Hand, Dan [P.E., Sustainable Enginerring; Witcher, James; Emerson, Michael A. [Senior V.P., ARES Corporation; Turner, Jeremy [Executive Director, NM Renewable Energy Transmission Authority; Sandidge, Wendy [Director of Operations, NM Community Capital

    2014-06-30

    The Pueblo of Zia will conduct a comprehensive feasibility study for best-use application(s) for development of renewable energy resources on its tribally held TRUST lands (i.e., Trust Lands of Zia Indian Reservation). The feasibility study is essential for determining the technical and economic viability of a future renewable project(s) on Zia tribal lands, including the potential economic and environmental benefits for the Tribe. Project Objectives: The feasibility study is essential for determining the technical and economic viability of future renewable project(s) on Zia tribal lands, including the potential economic and environmental benefits for the Tribe to: 1. Provide a balanced local renewable power supply for Zia Pueblo, its members, tribal offices, schools and buildings, and businesses on tribal lands 2. Provide a firm power supply for export and commercial market distribution 3. Provide economic development for the Tribe and its members, including job training and creation, each in accordance with the goals and objectives as conveyed by the Pueblo of Zia Tribal Council, Tribal Administration, and outlined in The Pueblo of Zia Comprehensive Plan and Pueblo of Zia — Zia Enterprise Zone Master Plan. A key goal of the study is to analyze the integrated development of solar, geothermal, and wind renewable energy resources at Zia Pueblo, with added potential to combine gas-fired generation to accomplish energy firming. Geothermal offers a base load source of energy, providing power continuously for end users. Wind and solar offer intermediate and peaking sources of energy, which can be harvested throughout the day, with periods of variable but predicable output. Variability will be managed in an integrated manner, using Zia Pueblo's combined renewable resources to generate high-quality power. Tasks are intended to collect, catalog, map, and analyze existing data on Zia Pueblo's renewable energy resource base and then match resource attributes with

  18. A cognitive behavioural group therapy for patients diagnosed with mild cognitive impairment and their significant others: feasibility and preliminary results

    NARCIS (Netherlands)

    Joosten-Weyn Banningh, L.W.A.; Kessels, R.P.C.; Olde Rikkert, M.G.M.; Geleijns-Lanting, C.E.

    2008-01-01

    Objective: To evaluate the feasibility and present preliminary results of a cognitive behavioural group therapy for patients with mild cognitive impairment and their significant others. Design: One group pretest-posttest design. Subjects: Twenty-two patients with mild cognitive impairment and their

  19. A cognitive behavioural group therapy for patients diagnosed with mild cognitive impairment and their significant others: feasibility and preliminary results.

    NARCIS (Netherlands)

    Joosten-Weyn Banningh, E.W.A.; Kessels, R.P.C.; Olde Rikkert, M.G.M.; Geleijns-Lanting, C.E.; Kraaimaat, F.W.

    2008-01-01

    OBJECTIVE: To evaluate the feasibility and present preliminary results of a cognitive behavioural group therapy for patients with mild cognitive impairment and their significant others. DESIGN: One group pretest-posttest design. SUBJECTS: Twenty-two patients with mild cognitive impairment and their

  20. Feasibility and Perception of Using Text Messages as an Adjunct Therapy for Low-Income, Minority Mothers With Postpartum Depression.

    Science.gov (United States)

    Broom, Matthew A; Ladley, Amy S; Rhyne, Elizabeth A; Halloran, Donna R

    2015-01-01

    Postpartum depression (PPD) is the most common medical problem among new mothers that can have a negative impact on infant health. Traditional treatments are often difficult for low-income mothers to complete, particularly given the numerous barriers families face. Among low-income, primarily racial, and ethnic minority mothers with postpartum depression, our aim was to evaluate (1) the feasibility of sending supportive text messages, and (2) the perception of receiving private, supportive text messages for postpartum depression. Mothers found to be at risk for postpartum depression received supportive text messages four times weekly for 6 months in addition to receiving access to traditional counseling services based within an academic pediatric office. Feasibility was evaluated along with cellular and text messaging use, access, and perception of the message protocol. Perception of the message protocol was evaluated at study completion via a Likert scale questionnaire and open-ended qualitative survey. In total, 4158/4790 (86.81%) text messages were successfully delivered to 54 mothers over a 6-month period at a low cost (US $777.60). Among the 96 scripted messages, 37 unique messages (38.54%) allowed for a response. Of all sent messages that allowed for responses, 7.30% (118/1616) were responded to, and 66.1% of those responses requested a call back; 46% (25/54) of mothers responded at least once to a text message. Mothers felt that messages were easily received and read (25/28, 89%) and relevant to them personally (23/28, 82%). Most shared texts with others (21/28, 75%). Text messaging is feasible, well-accepted, and may serve as a simple, inexpensive adjunct therapy well-suited to cross socioeconomic boundaries and provide private support for at-risk mothers suffering from postpartum depression.

  1. Feasibility of an image planning system for kilovoltage image-guided radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Thapa, Bishnu B.; Molloy, Janelle A. [Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky 40536-0293 (United States)

    2013-06-15

    Purpose: Image guidance has become a standard of care for many treatment scenarios in radiation therapy. This is most typically accomplished by use of kV x-ray devices mounted onto the linear accelerator (Linac) gantry that yield planar, fluoroscopic, and cone-beam computed tomography (CBCT) images. Image acquisition parameters are chosen via preset techniques that rely on broad categorizations in patient anatomy and imaging goal. However, the optimal imaging technique results in detectability of the features of interest while exposing the patient to minimum dose. Herein, the authors present an investigation into the feasibility of developing an image planning system (IPS) for radiotherapy.Methods: In this first phase, the authors focused on developing an algorithm to predict tissue contrast produced by a common radiotherapy planar imaging chain. Input parameters include a CT dataset and simulated planar imaging technique settings that include kV and mAs. Energy-specific attenuation through each voxel of the CT dataset was calculated in the algorithm to derive a net transmitted intensity. The response of the flat panel detector was integrated into the image simulation algorithm. Verification was conducted by comparing simulated and measured images using four phantoms. Comparisons were made in both high and low contrast settings, as well as changes in the geometric appearance due to image saturation. Results: The authors studied a lung nodule test object to assess the planning system's ability to predict object contrast and detectability. Verification demonstrated that the slope of the pixel intensities is similar, the presence of the nodule is evident, and image saturation at high mAs values is evident in both images. The appearance of the lung nodule is a function of the image detector saturation. The authors assessed the dimensions of the lung nodule in measured and simulated images. Good quantitative agreement affirmed the algorithm's predictive

  2. Pascua Yaqui Tribe Renewable Energy Development and Deployment Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Arvayo, Maria

    2014-05-30

    In 2012, PYT was awarded a grant from the Department of Energy Tribal Energy Program to conduct a Renewable Energy Development and Deployment Feasibility Study that would define the technical and economic viability of renewable energy on tribal lands. Red Mountain Energy Partners (RMEP) was hired by PYT to complete the study. Through this study, Red Mountain concluded that there are viable opportunities for solar at Tortuga Ranch, the Casino del Sol and a third site near the Justice Center on Camino de Oeste.

  3. Feasibility of guided cognitive behaviour therapy (CBT) self-help for childhood anxiety disorders in primary care.

    Science.gov (United States)

    Creswell, Cathy; Hentges, Francoise; Parkinson, Monika; Sheffield, Paul; Willetts, Lucy; Cooper, Peter

    2010-03-01

    Anxiety disorders in childhood are common, disabling and run a chronic course. Cognitive behaviour therapy (CBT) is effective but expensive and trained therapists are scarce. Guided self-help treatments may be a means of widening access to treatment. This study aimed to examine the feasibility of guided CBT self-help in primary care for childhood anxiety disorders, specifically in terms of therapist adherence, patient and therapist satisfaction and clinical gain.Participants were children aged between five and 12 years referred to two primary child and adolescent mental health services (PCAMHSs) in Oxfordshire, UK, who met diagnostic criteria for a primary anxiety disorder. Of the 52 eligible children, 41 anxious children were assessed for anxiety severity and interference before and after receiving CBT self-help delivered via a parent (total therapy time = five hours) by primary mental health workers (PMHWs). Therapy sessions were rated for treatment adherence and parents and PMHWs completed satisfaction questionnaires after treatment completion. Over 80% of therapy sessions were rated at a high level of treatment adherence. Parents and PMHWs reported high satisfaction with the treatment. Sixty-one percent of the children assessed no longer met the criteria for their primary anxiety disorder diagnosis following treatment, and 76% were rated as 'much'/'very much' improved on the Clinical Global Impression-Improvement (CGI-I) scale. There were significant reductions on parent and child report measures of anxiety symptoms, interference and depression. Preliminary exploration indicated that parental anxiety was associated with child treatment outcome. The findings suggest that guided CBT self-help represents a promising treatment for childhood anxiety in primary care.

  4. Feasibility and effect of home-based therapy programmes for children with cerebral palsy: a protocol for a systematic review.

    Science.gov (United States)

    Beckers, L W M E; Schnackers, M L A P; Janssen-Potten, Y J; Kleijnen, J; Steenbergen, B

    2017-02-24

    Given the promising advantages of upper extremity home-based programmes in children with cerebral palsy (CP), a systematic review of the available literature on this topic is warranted. The purpose of the systematic review described in this protocol is to investigate currently available home-based occupational therapy and physiotherapy programmes regarding both their feasibility and effect. This protocol describes a systematic review, developed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015. Studies will be included in which primary data are collected, participants are children aged physiotherapy intervention. Comparators of interest are: no therapy, care as usual, centre-based occupational therapy or physiotherapy, an alternative home-based programme and a medical intervention. Studies will be included that report either on feasibility (ie, acceptability, demand, implementation, practicality, adaptation, expansion or integration) or on efficacy/effectiveness (ie, child-related upper extremity outcomes within all International Classification of Functioning, Disability and Health levels or parent-related/caregiver-related outcomes on the psychological and social domain). Relevant studies will be identified by searching the databases MEDLINE, EMBASE, CINAHL, PsycINFO, PEDro, OTSeeker and CPCI-S as well as the trial registers ICTRP and CENTRAL, the reference lists of included records and by circulating a bibliography of the included records to authors of included studies. There will be no restrictions on language or year of publication. The search strategy consists of terms related to the population and intervention. Data will be extracted in duplicate using a digital data extraction form. The proposed study does not involve collection of primary data. Accordingly, no ethical approval is required. The authors will disseminate the findings of this systematic review through publication in a peer

  5. Mirror therapy in children with hemiplegia: a pilot study

    National Research Council Canada - National Science Library

    GYGAX, MARINE JEQUIER; SCHNEIDER, PATRICK; NEWMAN, CHRISTOPHER JOHN

    2011-01-01

    ...‐paretic arm, is used in the rehabilitation of hemiparesis after stroke in adults. We tested the effectiveness and feasibility of mirror therapy in children with hemiplegia by performing a pilot crossover study in ten participants (aged 6–14y...

  6. Feasibility of a classification system for physical therapy, occupational therapy, and sports therapy interventions for mobility and self-care in spinal cord injury rehabilitation

    NARCIS (Netherlands)

    van Langeveld, Sacha A.; Post, Marcel W.; van Asbeck, Floris W.; Postma, Karin; Leenders, Jacqueline; Pons, Kees

    Objective: To test the feasibility of a classification system developed to record the contents of treatment sessions intended to improve mobility and self-care by persons with a spinal cord injury (SCI) in clinical rehabilitation. Design: Descriptive study. Setting: Three Dutch SCI facilities.

  7. Feasibility study on the development of proton accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Ki Hyung; Bang, Hyung Chan; Cho, Yong Sup [Seoul National University, Seoul (Korea, Republic of); Kim, Young Rak [Church Environment Research Institute, Seoul (Korea, Republic of); Nam Kung, Won; Cho, Moo Hyun [Pohang University of Science and Technology, Pohang (Korea, Republic of); Seo, Tae Suk [Cartolrik University, Seoul (Korea, Republic of); Woo, Hyung Joo [Nature Research Institute, Seoul (Korea, Republic of); Lee, Kyung Soo [Basic Study Research Institute, Seoul (Korea, Republic of); Lee, Hun Joo [Cheju National University, Cheju (Korea, Republic of); Chang, Soon Hong; Cho, Nam Jin [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Han, Jeon Kun [Sungkyunkwan University, Seoul (Korea, Republic of)

    1996-10-01

    A feasibility on the development of a high energy proton accelerator to be used for R and D in the nuclear field of korea was studied. The proposed one is a proton linac with parameters of about 1 GeV, 20 mA which can supply enough neutrons by the spallation reaction to drive a subcritical reactor. It= is expected to solve the intrinsic problem in the nuclear field such as safety, nuclear waste, proliferation and resource. The study was carried out through a multi-institutional cooperation of universities, institute and industry for a national consensus. 5 refs., 8 tabs., 8 figs. (author)

  8. Comparative Anatomy of Maintenance Tasks (CAMT): A Feasibility Study

    Science.gov (United States)

    1992-03-01

    0o0.1-560 Standard Form2 i 298-102 TABLE OF CONTENTS Section Page I. THEORY 1-1 The Requirement 1-1 Associated Concepts 1-4 Comparative Anatomy 1-4 The...AD-A248 709 -AL-TP-1992-0007 lllllillllllllllir COMPARATIVE ANATOMY OF MAINTENANCE TASKS (CAMT): A FEASIBIUTY STUDY A Andrew P. Chenzoff...1989 - 1 September 1990 4. TITLE AND SUBTITLE S. FUNDING NUMBERS Comparative Anatomy of Maintenance Tasks (CAMT): A Feasibility Study C - F33615-87-D

  9. Swallowing rehabilitation of dysphagic tracheostomized patients under mechanical ventilation in intensive care units: a feasibility study.

    Science.gov (United States)

    Rodrigues, Katia Alonso; Machado, Flávia Ribeiro; Chiari, Brasília Maria; Rosseti, Heloísa Baccaro; Lorenzon, Paula; Gonçalves, Maria Inês Rebelo

    2015-01-01

    The aim of the present study was to assess the feasibility of the early implementation of a swallowing rehabilitation program in tracheostomized patients under mechanical ventilation with dysphagia. This prospective study was conducted in the intensive care units of a university hospital. We included hemodynamically stable patients under mechanical ventilation for at least 48 hours following 48 hours of tracheostomy and with an appropriate level of consciousness. The exclusion criteria were previous surgery in the oral cavity, pharynx, larynx and/or esophagus, the presence of degenerative diseases or a past history of oropharyngeal dysphagia. All patients were submitted to a swallowing rehabilitation program. An oropharyngeal structural score, a swallowing functional score and an otorhinolaryngological structural and functional score were determined before and after swallowing therapy. We included 14 patients. The mean duration of the rehabilitation program was 12.4 ± 9.4 days, with 5.0 ± 5.2 days under mechanical ventilation. Eleven patients could receive oral feeding while still in the intensive care unit after 4 (2 - 13) days of therapy. All scores significantly improved after therapy. In this small group of patients, we demonstrated that the early implementation of a swallowing rehabilitation program is feasible even in patients under mechanical ventilation.

  10. Feasibility of Pencil Beam Scanned Intensity Modulated Proton Therapy in Breath-hold for Locally Advanced Non-Small Cell Lung Cancer

    DEFF Research Database (Denmark)

    Gorgisyan, Jenny; Munck Af Rosenschold, Per; Perrin, Rosalind

    2017-01-01

    with image guided photon radiation therapy were included in the present simulation study. In addition to a planning breath-hold computed tomography (CT) scan before the treatment start, a median of 6 (range 3-9) breath-hold CT scans per patient were acquired prospectively throughout the radiation therapy......) in terms of the percentage of voxels with 3-mm or more undershoot on repeat CT scans. The dose to the organs at risk was similar for the planned and simulated dose distributions. Three or fewer breath-holds per field would be required for 12 of the 15 patients, which was clinically feasible. CONCLUSIONS...

  11. DOT-C: A cluster randomised feasibility trial evaluating directly observed anti-HCV therapy in a population receiving opioid substitute therapy from community pharmacy.

    Science.gov (United States)

    Radley, Andrew; Tait, Jan; Dillon, John F

    2017-09-01

    Direct-acting antiviral therapy (DAAs) for hepatitis C infection (HCV) have a much smaller burden of treatment than interferon-based regimes, require less monitoring and are very effective. New pathways are required to increase access to treatment amongst people prescribed opioid substitution therapy (OST). An exploratory cluster randomised controlled trial with mixed methods evaluation was undertaken to compare the uptake of dried blood spot testing (DBST) and treatment of people with genotype 1 HCV infection in a conventional service pathway versus a pharmacist-led pathway in a population receiving OST. Pharmacies randomised to the conventional pathway obtained 58 DBST from 244 patients (24%):15 new reactive tests and 33 new negative tests were identified. Within the pharmacist-led pathway, 94 DBST were obtained from 262 patients (36%): 26 new reactive tests and 54 new negative tests were identified. Participants in the pharmacist-led pathway were more likely to take a DBST (ptreatment through the conventional pathway, 4 patients from 15 with new reactive tests (27%) attended clinic for assessment. In the pharmacist-led treatment pathway, 20 patients from 26 with new reactive tests (77%) attended for assessment blood tests. Participants in the pharmacist-led pathway were more likely to proceed through the assessment for treatment (ptreatment through the conventional pathway and three patients completed treatment through the pharmacist-led pathway. The process evaluation identified key themes important to service user completers and staff participants. The study provides evidence that testing and treatment for HCV in a pharmacist led-pathway is a feasible treatment pathway for people who receive supervised OST consumption through community pharmacies. This feasibility trial therefore provides sufficient confirmation to justify proceeding to a full trial. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Feasibility study of gasification of oil palm fronds

    Directory of Open Access Journals (Sweden)

    S.A. Sulaiman

    2015-12-01

    Full Text Available Considering the large and consistent supply, oil palm fronds could be a promising source of biomass energy through gasification. There is very scarce information on the characteristics of oil palm fronds, which is vital in deciding if such biomass is technically suitable for gasification. In the present work, the feasibility of oil palm fronds for biomass gasification is studied. The study is conducted experimentally via standard tests to determine their thermochemical characteristics. Ultimate analysis is conducted to determine the contents of carbon, nitrogen, hydrogen and sulphide in oil palm fronds. Proximate analysis is performed to identify the burning characteristics of the biomass. The energy content in the fronds is determined by using a bomb calorie meter and is around 18 MJ/kg. The ignitability of the fronds is also studied experimentally to assess the ease to start-up combustion of the fronds. The characteristics of the flame of the resulting syngas from gasification of oil palm fronds are qualitatively studied. Simulated syngas composition study reveals potentials of 22% CO, 1.3% H2, 18.5% CO2 and traces of CH4. The study is extended to computer simulation to predict composition of the syngas. It is found from this work that oil palm fronds are feasible for gasification and has a good potential as a renewable energy source.

  13. Use and feasibility of telemedicine technology in the dissemination of Parent-Child Interaction Therapy.

    Science.gov (United States)

    Funderburk, Beverly W; Ware, Lisa M; Altshuler, Elizabeth; Chaffin, Mark

    2008-11-01

    This brief report discusses the use and feasibility of telemedicine technology in the dissemination of Parent-Child Interaction Therapy (PCIT). PCIT is an empirically supported behavioral parent training program for reducing disruptive behavior in young children and for reducing future rates of child physical abuse. The positive impact PCIT has demonstrated in reducing child maltreatment has galvanized interest in widespread dissemination of the PCIT model into child service systems. PCIT has traditionally been taught in university-based training programs in a mentored cotherapy model. By contrast, in field settings, PCIT training typically consists of workshop training supplemented by a period of telephone consultation (PC). Given concerns with the level of practitioner competency and fidelity yielded by the PC model, PCIT training programs have begun to examine Internet-based telemedicine technology to deliver live, mentored PCIT training to trainees at remote locations (Remote Real-Time or RRT) to better approximate the university-based training model. Challenges of disseminating evidence-based practices are discussed, using PCIT as a model of how these challenges are being addressed by telemedicine technology.

  14. Feasibility Study on Thimble Plug Removal for Westinghouse Type PWR

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Sup; Lee, Jae Yong; Yoon, Duk Joo; Jun, Hwang Yong; Kim, Yoon Ho [Korea Electric Power Research Institute, Taejon (Korea, Republic of)

    1996-12-31

    1. Abstract of Thimble Plug Removal- Thimble Plug Removal from the core increase core bypass flow few percent and may reduce DNBR Margin 2{approx}3%. In this feasibility study, the following analyses were performed in terms of the best estimate flow, bypass flow, DNBR margin etc. 2. Area of analysis and evaluations (a). Thermal Hydraulic (b). PCWG (c). Nuclear Design (d). Rod Performance (e). mechanical Design (f). Transient Analysis (g). LOCA Analysis. 3. Evaluation of Economic and Licensing 4. Detail analysis and design were performed for Youngkwang unit 1 as a sample plant. (author). 68 refs., figs.

  15. Feasibility Study for Operable Unit 7-13/14

    Energy Technology Data Exchange (ETDEWEB)

    K. Jean Holdren

    2007-05-29

    The Subsurface Disposal Area is a radioactive waste landfill located within the Radioactive Waste Management Complex at the Idaho National Laboratory Site in southeastern Idaho. This Feasibility Study for Operable Unit 7-13/14 analyzes options for mitigating risks to human health and the environment associated with the landfill. Analysis is conducted in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act, using nine evaluation criteria to develop detailed and comparative analysis of five assembled alternatives. Assembled alternatives are composed of discrete modules. Ultimately, decision-makers will select, recombine, and sum various modules into an optimized preferred alternative and final remedial decision.

  16. Feasibility study. Solar energy in Norway; Mulighetsstudie. Solenergi i Norge

    Energy Technology Data Exchange (ETDEWEB)

    Halvorsen, Una; Bernhard, Peter; Salvesen, Fritjof; Bugge, Lars; Andresen, Inger; Simonsen, Ingeborg

    2011-07-01

    On behalf of Enova KanEnergi and SINTEF summarized the results of the project 'Feasibility study. Solar energy' in a report. The purpose of this report is to outline an overview of the potential for solar energy in Norway to be realized until 2020. This is a survey of the status of technology and associated costs related to energy production, as well as a description of the market conditions. This report is a contribution to Enova's ongoing strategy and development. (eb)

  17. A feasibility study on a superconducting power transformer

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, M.; Ishigohka, T.; Mizukami, N.; Ohshima, K.

    1986-09-01

    The feasibility of a UHV superconducting transformer (SCT) in an electric power system is studied. A 1100/500kV, 1750 MVA SCT is conceptually designed, which has windings of ultra-fine filament superconducting wire and an amorphous alloy core. The total loss of the SCT is calculated to be about 300kW at room temperature assuming that the refrigerator efficiency is 1/500. In this calculation, the heat leak loss, stray loss, etc., are included. This value of the total loss is about 20 - 25% of that of conventional transformers.

  18. Feasibility study for the United Heckathorn Superfund Site, Richmond, California

    Energy Technology Data Exchange (ETDEWEB)

    Lincoff, A.H. [US Environmental Protection Agency, San Francisco, CA (United States). Region IX; Costan, G.P.; Montgomery, M.S.; White, P.J. [Pacific Northwest Lab., Richland, WA (United States)

    1994-07-01

    The United Heckathom Superfund Site in Richmond, California, was used to formulate pesticides from approximately 1947 to 1966. Soils at the site and sediments in the harbor were contaminated with various chlorinated pesticides, primarily DDT, as a result of these activities. The US Environmental Protection Agency listed the site on the Superfund National Priorities List in 1990. This document is part of the Remedial Investigation and Feasibility Study phase of the Superfund response, which will provide the basis for selection of a final remedy that will protect human health and the environment and achieve compliance with federal and state envirorunental laws.

  19. Feasibility Study of Biomass Electrical Generation on Tribal Lands

    Energy Technology Data Exchange (ETDEWEB)

    Tom Roche; Richard Hartmann; Joohn Luton; Warren Hudelson; Roger Blomguist; Jan Hacker; Colene Frye

    2005-03-29

    The goals of the St. Croix Tribe are to develop economically viable energy production facilities using readily available renewable biomass fuel sources at an acceptable cost per kilowatt hour ($/kWh), to provide new and meaningful permanent employment, retain and expand existing employment (logging) and provide revenues for both producers and sellers of the finished product. This is a feasibility study including an assessment of available biomass fuel, technology assessment, site selection, economics viability given the foreseeable fuel and generation costs, as well as an assessment of the potential markets for renewable energy.

  20. Remote autopsy services: A feasibility study on nine cases.

    Science.gov (United States)

    Vodovnik, Aleksandar; Aghdam, Mohammad Reza F; Espedal, Dan Gøran

    2017-01-01

    Introduction We have conducted a feasibility study on remote autopsy services in order to increase the flexibility of the service with benefits for teaching and interdepartmental collaboration. Methods Three senior staff pathologists, one senior autopsy technician and one junior resident participated in the study. Nine autopsies were performed by the autopsy technician or resident, supervised by the primary pathologist, through the secure, double encrypted video link using Jabber Video (Cisco) with a high-speed broadband connection. The primary pathologist and autopsy room each connected to the secure virtual meeting room using 14″ laptops with in-built cameras (Hewlett-Packard). A portable high-definition web camera (Cisco) was used in the autopsy room. Primary and secondary pathologists independently interpreted and later compared gross findings for the purpose of quality assurance. The video was streamed live only during consultations and interpretation. A satisfaction survey on technical and professional aspects of the study was conducted. Results Independent interpretations of gross findings between primary and secondary pathologists yielded full agreement. A definite cause of death in one complex autopsy was determined following discussions between pathologists and reviews of the clinical notes. Our satisfaction level with the technical and professional aspects of the study was 87% and 97%, respectively. Discussion Remote autopsy services are found to be feasible in the hands of experienced staff, with increased flexibility and interest of autopsy technicians in the service as a result.

  1. A feasibility study of educational tools for osteomalacia.

    Science.gov (United States)

    Waxman, R; Adebajo, A; Robinson, S; Walker, D; Johnson, M; Rahman, A; Samanta, A; Kumar, K; Raza, K; Helliwell, P

    2017-03-01

    Many people in the UK, particularly people of South Asian origin, are advised to supplement their vitamin D intake, yet most do not. This suggests an unmet educational need. The osteomalacia mind map was developed to meet this need. The mind map contains culturally sensitive images, translated into Urdu and made interactive on a DVD. This study explores the feasibility of a randomised controlled study to measure the effect of education on improving vitamin D knowledge and adherence. This was a pilot and feasibility study. Cluster randomisation was used to avoid inter person contamination. Two South Asian women's groups were recruited to receive information about osteomalacia either by interactive DVD or an Arthritis Research UK leaflet. Knowledge and compliance were tested before and after the educational interventions via a knowledge questionnaire and the measurement of vitamin D and parathormone levels. The groups were found to be mismatched for knowledge, educational attainment and language at baseline. There were also organisational difficulties and possible confounding due to different tutors and translators. The DVD group had high knowledge at baseline which did not improve. The leaflet group had low knowledge at baseline that did improve. The DVD group had lower parathormone which did not change. The leaflet group had an increase in vitamin D but parathormone remained high. Performing a randomised study with this population utilising an educational intervention was difficult to execute. If cluster randomisation is used, extreme care must be taken to match the groups at baseline.

  2. Dosimetric feasibility study for an extracorporeal BNCT application on liver metastases at the TRIGA Mainz.

    Science.gov (United States)

    Blaickner, M; Kratz, J V; Minouchehr, S; Otto, G; Schmidberger, H; Schütz, C; Vogtländer, L; Wortmann, B; Hampel, G

    2012-01-01

    This study investigates the dosimetric feasibility of Boron Neutron Capture Therapy (BNCT) of explanted livers in the thermal column of the research reactor in Mainz. The Monte Carlo code MCNP5 is used to calculate the biologically weighted dose for different ratios of the (10)B-concentration in tumour to normal liver tissue. The simulation results show that dosimetric goals are only partially met. To guarantee effective BNCT treatment the organ has to be better shielded from all gamma radiation. Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. Economic and technical feasibility study of compressed air storage

    Energy Technology Data Exchange (ETDEWEB)

    1976-03-01

    The results of a study of the economic and technical feasibility of compressed air energy storage (CAES) are presented. The study, which concentrated primarily on the application of underground air storage with combustion turbines, consisted of two phases. In the first phase a general assessment of the technical alternatives, economic characteristics and the institutional constraints associated with underground storage of compressed air for utility peaking application was carried out. The goal of this assessment was to identify potential barrier problems and to define the incentive for the implementation of compressed air storage. In the second phase, the general conclusions of the assessment were tested by carrying out the conceptual design of a CAES plant at two specific sites, and a program of further work indicated by the assessment study was formulated. The conceptual design of a CAES plant employing storage in an aquifer and that of a plant employing storage in a conventionally excavated cavern employing a water leg to maintain constant pressure are shown. Recommendations for further work, as well as directions of future turbo-machinery development, are made. It is concluded that compressed air storage is technically feasible for off-peak energy storage, and, depending on site conditions, CAES plants may be favored over simple cycle turbine plants to meet peak demands. (LCL)

  4. Assessment of apical periodontitis by MRI. A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Geibel, M.A. [Ulm Univ. (Germany). Oral and Maxillofacial Surgery; Schreiber, E.S.; Bracher, A.K.; Rasche, V. [Ulm Univ. (Germany). Internal Medicine II; Hell, E.; Ulrici, J. [Sirona Dental Systems GmbH, Bensheim (Germany). Dental Imaging; Sailer, L.K. [DOC Praxisklinik im Wiley, Neu-Ulm (Germany). MKG; Ozpeynirci, Y. [Ulm Univ. (Germany). Diagnostic and Interventional Radiology

    2015-04-15

    The purpose of this clinical feasibility study was to evaluate the applicability of magnetic resonance imaging (MRI) for the assessment of apical periodontitis in direct comparison with cone beam CT (CBCT). 19 consecutive patients (average age 43 ± 13 years) with 34 lesions in total (13 molars, 14 premolars and 7 front teeth) were enrolled in this feasibility study. Periapical lesions were defined as periapical radiolucencies (CBCT) or structural changes in the spongy bone signal (MRI), which were connected with the apical part of a root and with at least twice the width of the periodontal ligament space. The location and dimension of the lesions were compared between MRI and CBCT. While mainly mineralized tissue components such as teeth and bone were visible with CBCT, complimentary information of the soft tissue components was assessable with MRI. The MRI images provided sufficient diagnostic detail for the assessment of the main structures of interest. Heterogeneous contrast was observed within the lesion, with often a clear enhancement close to the apical foramen and the periodontal gap. No difference for lesion visibility was observed between MRI and CBCT. The lesion dimensions corresponded well, but were slightly but significantly overestimated with MRI. A heterogeneous lesion appearance was observed in several patients. Four patients presented with a well circumscribed hyperintense signal in the vicinity of the apical foramen. The MRI capability of soft tissue characterization may facilitate detailed analysis of periapical lesions. This clinical study confirms the applicability of multi-contrast MRI for the identification of periapical lesions.

  5. Fusion Guidance in Endovascular Peripheral Artery Interventions: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Sailer, Anna M., E-mail: anni.sailer@mumc.nl; Haan, Michiel W. de, E-mail: m.de.haan@mumc.nl; Graaf, Rick de, E-mail: r.de.graaf@mumc.nl; Zwam, Willem H. van, E-mail: w.van.zwam@mumc.nl [Maastricht University Medical Center, Department of Radiology (Netherlands); Schurink, Geert Willem H., E-mail: gwh.schurink@mumc.nl [Maastricht University Medical Center, Department of Surgery (Netherlands); Nelemans, Patricia J., E-mail: patty.nelemans@maastrichtuniversity.nl [Maastricht University Medical Centre, Department of Epidemiology (Netherlands); Wildberger, Joachim E., E-mail: j.wildberger@mumc.nl; Das, Marco, E-mail: m.das@mumc.nl [Maastricht University Medical Center, Department of Radiology (Netherlands)

    2015-04-15

    PurposeThis study was designed to evaluate the feasibility of endovascular guidance by means of live fluoroscopy fusion with magnetic resonance angiography (MRA) and computed tomography angiography (CTA).MethodsFusion guidance was evaluated in 20 endovascular peripheral artery interventions in 17 patients. Fifteen patients had received preinterventional diagnostic MRA and two patients had undergone CTA. Time for fluoroscopy with MRA/CTA coregistration was recorded. Feasibility of fusion guidance was evaluated according to the following criteria: for every procedure the executing interventional radiologists recorded whether 3D road-mapping provided added value (yes vs. no) and whether PTA and/or stenting could be performed relying on the fusion road-map without need for diagnostic contrast-enhanced angiogram series (CEAS) (yes vs. no). Precision of the fusion road-map was evaluated by recording maximum differences between the position of the vasculature on the virtual CTA/MRA images and conventional angiography.ResultsAverage time needed for image coregistration was 5 ± 2 min. Three-dimensional road-map added value was experienced in 15 procedures in 12 patients. In half of the patients (8/17), intervention was performed relying on the fusion road-map only, without diagnostic CEAS. In two patients, MRA roadmap showed a false-positive lesion. Excluding three patients with inordinate movements, mean difference in position of vasculature on angiography and MRA/CTA road-map was 1.86 ± 0.95 mm, implying that approximately 95 % of differences were between 0 and 3.72 mm (2 ± 1.96 standard deviation).ConclusionsFluoroscopy with MRA/CTA fusion guidance for peripheral artery interventions is feasible. By reducing the number of CEAS, this technology may contribute to enhance procedural safety.

  6. Feasibility study of an attention training application for older adults.

    Science.gov (United States)

    Hill, Nikki L; Mogle, Jacqueline; Colancecco, Elise; Dick, Robert; Hannan, John; Lin, Feng Vankee

    2015-09-01

    Technology-based attention training has demonstrated promise in its potential to improve cognitive functioning in older people. Developing mobile applications, with older users specifically in mind, may support future dissemination of these interventions and integration into daily life. The purpose of this pilot study was to test the feasibility of an Attention Training Application (ATA) for community-dwelling older adults using mobile technology. A descriptive, mixed-methods design was used to capture older adults' feedback on the usability and acceptability of the ATA. A convenience sample of older adults (n = 9) from two independent living facilities participated in a 2-hour training and practice session with the ATA. Participants were given personally tailored instructions for using the mobile device and the ATA specifically. Following a practice session, participants provided ratings on multiple components of the ATA and completed an audio-recorded, semi-structured interview to provide detailed descriptions of their experience and perceptions. An iterative process of content analysis was used to characterise the open-ended responses. Participants rated the ATA favourably overall on several 0-10 scales including likeability [8.5 (1.6)], interest [8.8 (2.3)] and satisfaction [8.2 (1.9)]. The qualitative analyses revealed several issues relevant to the feasibility of the ATA among older people including the importance of the technological background of the user, limiting negative feedback, challenges with the touch screen interface, personal preferences for challenge, extending the practice period and the difficulty of the dual-task condition. The use of the ATA is feasible in the older adult population. Future development should specifically consider personal characteristics as well as preferences to maximise usability and acceptability among older people. Older adults enjoyed the ATA. This opens doors to user-friendly technological interventions that may be

  7. Feasibility of photodynamic therapy for secondary hyperparathyroidism in chronic renal failure rats.

    Science.gov (United States)

    Miyakogawa, Takayo; Kanai, Genta; Tatsumi, Ryoko; Takahashi, Hiroo; Sawada, Kaichiro; Kakuta, Takatoshi; Fukagawa, Masafumi

    2017-08-01

    Feasibility of photodynamic therapy (PDT) for secondary hyperparathyroidism (SHPT) was examined in a rat model of SHPT. A photosensitizer, 5-aminolevulinic acid (5-ALA), was injected intraperitoneally, and the parathyroid glands were irradiated either after surgical exposure with 385-nm light or transdermally with 630-nm light from a light-emitting diode (LED) lamp. PDT with high 5-ALA and irradiation doses caused severe hypoparathyroidism in SHPT rats within two days. Low-dose invasive PDT reduced intact parathyroid hormone (iPTH) levels in all rats from 748.9 ± 462.6 pg/mL at baseline to 138.7 ± 117.5 pg/mL at week 6, followed by a further decrease to 80.5 ± 54.0 pg/mL at week 9 in 60 % of rats or an increase to 970.0 ± 215.6 pg/mL at week 9 in 40 % of rats. Low-dose noninvasive PDT reduced iPTH levels from 1612.5 ± 607.8 pg/mL at baseline to 591.9 ± 480.1 pg/mL at week 4 in all rats. Thereafter, iPTH levels remained low in 43 % of rats and were 233.7 ± 51.6 pg/mL at week 9, whereas 57 % showed an increase, reaching 3305.9 ± 107.3 pg/mL at week 9. Control SHPT rats had iPTH levels of 2487.8 ± 350.9 and 2974.6 ± 372.1 pg/mL at week 4 and 9, respectively. The parathyroid glands of the rats with low iPTH levels were atrophied and had few parathyroid cells surrounded by fibrotic materials and no recognizable blood vessels. Those of the rats with high iPTH levels showed well-preserved gland structure, clusters of parathyroid cells, and blood vessels. These results demonstrate that 5-ALA-mediated PDT for SHPT is feasible.

  8. Intensification of donor interviewing procedures: a feasibility study.

    Science.gov (United States)

    van Rhenen, D J; Molijn, M H; Gorgels, J; van der Linden, J M; Ko, L K

    1996-02-01

    To determine the feasibility and acceptability for the blood donor of an intensified blood donor interviewing procedure on high-risk factors for infectious diseases. To answer the question whether an intensified blood donor interviewing procedure would lead to an unacceptable loss of blood donors. Feasibility study. Red Cross Bloodbank Rotterdam. DONORS: Study group of 240 first-time donors. Intensified donor interviewing techniques by direct questioning and workload assessment. Intensified interviewing was welcomed by 88-91% of first-time donors and rejected by 2-5%. On the question whether the intensified interviewing procedure should be the standard approach of the blood bank the answer was positive in 76-82% of first-time donors and negative in 11-14%. No blood donors indicated that this would be a reason to withdraw from blood donation. The workload for the blood bank physician increased by approximately 30%. The approach of intensified donor interviewing techniques in first-time donors is acceptable both to the donors and the blood bank workload.

  9. Stereotactic intensity-modulated radiation therapy (IMRT) and inverse treatment planning for advanced pleural mesothelioma. Feasibility and initial results

    Energy Technology Data Exchange (ETDEWEB)

    Muenter, M.W.; Thilmann, C.; Hof, H.; Debus, J. [Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (dkfz), Heidelberg (Germany); Nill, S.; Hoess, A.; Partridge, M. [Dept. of Medical Physics, German Cancer Research Center (dkfz), Heidelberg (Germany); Haering, P. [Dept. of Central Dosimetry, German Cancer Research Center (dkfz), Heidelberg (Germany); Manegold, C. [Dept. of Medical Oncology/Internal Medicine, Thoraxklinik Heidelberg gGmbH, Heidelberg (Germany); Wannenmacher, M. [Dept. of Clinical Radiology, Univ. of Heidelberg, Heidelberg (Germany)

    2003-08-01

    Background and Purpose: Complex-shaped malignant pleural mesotheliomas (MPMs) with challenging volumes are extremely difficult to treat by conventional radiotherapy due to tolerance doses of the surrounding normal tissue. In a feasibility study, we evaluated if inversely planned stereotactic intensity-modulated radiation therapy (IMRT) could be applied in the treatment of MPM. Patients and Methods: Eight patients with unresectable lesions were treated after failure of chemotherapy. All patients were positioned using noninvasive patient fixation techniques which can be attached to the applied extracranial stereotactic system. Due to craniocaudal extension of the tumor, it was necessary to develop a special software attached to the inverse planning program KonRad, which can connect two inverse treatment plans and consider the applied dose of the first treatment plan in the area of the matchline of the second treatment plan. Results: Except for one patient, in whom radiotherapy was canceled due to abdominal metastasis, treatment could be completed in all patients and was well tolerated. Median survival after diagnosis was 20 months and after IMRT 6.5 months. Therefore, both the 1-year actuarial overall survival from the start of radiotherapy and the 2-year actuarial overall survival since diagnosis were 28%. IMRT did not result in clinically significant acute side effects. By using the described inverse planning software, over- or underdosage in the region of the field matchline could be prevented. Pure treatment time ranged between 10 and 21 min. Conclusion: This study showed that IMRT is feasible in advanced unresectable MPM. The presented possibilities of stereotactic IMRT in the treatment of MPM will justify the evaluation of IMRT in early-stage pleural mesothelioma combined with chemotherapy in a study protocol, in order to improve the outcome of these patients. Furthermore, dose escalation should be possible by using IMRT. (orig.)

  10. Mobile App-Delivered Cognitive Behavioral Therapy for Insomnia: Feasibility and Initial Efficacy Among Veterans With Cannabis Use Disorders.

    Science.gov (United States)

    Babson, Kimberly A; Ramo, Danielle E; Baldini, Lisa; Vandrey, Ryan; Bonn-Miller, Marcel O

    2015-07-17

    Cannabis is the most frequently used illicit substance in the United States resulting in high rates of cannabis use disorders. Current treatments for cannabis use are often met with high rates of lapse/relapse, tied to (1) behavioral health factors that impact cannabis use such as poor sleep, and (2) access, stigma, supply, and cost of receiving a substance use intervention. This pilot study examined the feasibility, usability, and changes in cannabis use and sleep difficulties following mobile phone-delivered Cognitive Behavioral Therapy for Insomnia (CBT-I) in the context of a cannabis cessation attempt. Four male veterans with DSM-5 cannabis use disorder and sleep problems were randomized to receive a 2-week intervention: CBT-I Coach mobile app (n=2) or a placebo control (mood-tracking app) (n=2). Cannabis and sleep measures were assessed pre- and post-treatment. Participants also reported use and helpfulness of each app. Changes in sleep and cannabis use were evaluated for each participant individually. Both participants receiving CBT-I used the app daily over 2 weeks and found the app user-friendly, helpful, and would use it in the future. In addition, they reported decreased cannabis use and improved sleep efficiency; one also reported increased sleep quality. In contrast, one participant in the control group dropped out of the study, and the other used the app minimally and reported increased sleep quality but also increased cannabis use. The mood app was rated as not helpful, and there was low likelihood of future participation. This pilot study examined the feasibility and initial patient acceptance of mobile phone delivery of CBT-I for cannabis dependence. Positive ratings of the app and preliminary reports of reductions in cannabis use and improvements in sleep are both encouraging and support additional evaluation of this intervention.

  11. Network management systems for active distribution networks. A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, D.A.

    2004-07-01

    A technical feasibility study on network management systems for active distribution networks is reported. The study investigated the potential for modifying a Distribution Network Operator (DNO) Supervisory Control and Data Acquisition System (SCADA) to give some degree of active management. Government incentives have encouraged more and more embedded generation being connected to the UK distribution networks and further acceleration of the process should support the 2010 target for a reduction in emissions of carbon dioxide. The report lists the objectives of the study and summarises what has been achieved; it also discusses limitations, reliability and resilience of existing SCADA. Safety and operational communications are discussed under staff safety and operational safety. Recommendations that could facilitate active management through SCADA are listed, together with suggestions for further study. The work was carried out as part of the DTI New and Renewable Energy Programme managed by Future Energy Solutions.

  12. Expressive writing in patients receiving palliative care: a feasibility study.

    Science.gov (United States)

    Bruera, Eduardo; Willey, Jie; Cohen, Marlene; Palmer, J Lynn

    2008-01-01

    Patients with advanced cancer receiving palliative care often experience severe physical and psychosocial symptoms. However, there are limited resources for psychological and emotional support. Expressive writing has shown decreased anxiety level in young and healthy people suffering from a number of stressors. The purpose of this study was to determine the feasibility of expressive writing in patients receiving palliative care and the most suitable outcomes of expressive writing in this patient population. In this pilot study, patients were randomly assigned to either the expressive writing group (EW) or the neutral writing group (NW). Anxiety level before and after the writing session was compared between the two groups. Writing materials were content analyzed using standard qualitative research methods. A total of 24 patients (12 in EW and 12 in NW) were enrolled in the study between October 2006 and January 2007. Although the majority of patients (83%-100%) were able to complete all baseline assessments, poor adherence was observed during the follow-ups. Only 8% of patients completed the 2-week study. There was no significant difference in the State-Trait Anxiety Inventory (STAI) State-Anxiety scores at baseline, before and after each writing session between the EW and NW groups. Our rapid accrual suggests that palliative care patients are interested in participating in studies such as expressive writing. The high level of adherence to the baseline assessments indicates that these assessments were not particularly difficult for our patients to complete. Future studies may need to include patients with better performance status, better patient education, means of emotional expression (i.e., audio recording, telephone interview) and improved adherence. We conclude that clinical trials of expressive writing in the palliative care setting are not feasible unless they undergo major modification in methods compared to those previous reported in other patient

  13. The Ronnie Gardiner Rhythm and Music Method - a feasibility study in Parkinson's disease.

    Science.gov (United States)

    Pohl, Petra; Dizdar, Nil; Hallert, Eva

    2013-01-01

    To assess the feasibility of the novel intervention, Ronnie Gardiner Rhythm and Music (RGRM™) Method compared to a control group for patients with Parkinson's disease (PD). Eighteen patients, mean age 68, participating in a disability study within a neurological rehabilitation centre, were randomly allocated to intervention group (n = 12) or control group (n = 6). Feasibility was assessed by comparing effects of the intervention on clinical outcome measures (primary outcome: mobility as assessed by two-dimensional motion analysis, secondary outcomes: mobility, cognition, quality of life, adherence, adverse events and eligibility). Univariable analyses showed no significant differences between groups following intervention. However, analyses suggested that patients in the intervention group improved more on mobility (p = 0.006), cognition and quality of life than patients in the control group. There were no adverse events and a high level of adherence to therapy was observed. In this disability study, the use of the RGRM™ Method showed promising results in the intervention group and the adherence level was high. Our results suggest that most assessments chosen are eligible to use in a larger randomized controlled study for patients with PD. The RGRM™ Method appeared to be a useful and safe method that showed promising results in both motor and cognitive functions as well as quality of life in patients with moderate PD. The RGRM™ Method can be used by physiotherapists, occupational, speech and music therapists in neurological rehabilitation. Most measurements were feasible except for Timed-Up-and-Go.

  14. Yoga for Health-Related Quality of Life in Adult Cancer: A Randomized Controlled Feasibility Study

    Directory of Open Access Journals (Sweden)

    Marcy McCall

    2015-01-01

    Full Text Available An increase in patient-led uptake of complementary therapies in adult cancer has led to a need for more rigorous study of such interventions and their outcomes. This study therefore aimed to evaluate the feasibility and acceptability of a yoga intervention in men and women receiving conventional treatment for a cancer diagnosis. Prospective, mixed methods feasibility trial allocated participants to receive one of three yoga interventions over a four-week study period. Data collection was completed through online survey of QOL-CA/CS and customized surveys. Fifteen participants were included (11 female undergoing treatment for breast, prostate, colorectal, brain, and blood and lung cancer. Two participants dropped out and complete qualitative and quantitative data sets were collected from 12 participants and four yoga instructors. Other outcome measures included implementation costs patient-reported preferences for yoga intervention and changes in QOL-CA/CS. Three types of yoga intervention were safely administered in adult cancer. Mixed methods, cost-efficiency, QOL-CA/CS, and evidence-based design of yoga intervention have been used to establish feasibility and patient-preferences for yoga delivery in adult caner. Results suggest that, with some methodological improvements, a large-scale randomized controlled trial is warranted to test the efficacy of yoga for male and female cancer patients. This trial is registered with Clinicaltrials.gov NCT02309112.

  15. Battery energy storage market feasibility study -- Expanded report

    Energy Technology Data Exchange (ETDEWEB)

    Kraft, S. [Frost and Sullivan, Mountain View, CA (United States); Akhil, A. [Sandia National Labs., Albuquerque, NM (United States). Energy Storage Systems Analysis and Development Dept.

    1997-09-01

    Under the sponsorship of the US Department of Energy`s Office of Utility Technologies, the Energy Storage Systems Analysis and Development Department at Sandia National Laboratories (SNL) contracted Frost and Sullivan to conduct a market feasibility study of energy storage systems. The study was designed specifically to quantify the battery energy storage market for utility applications. This study was based on the SNL Opportunities Analysis performed earlier. Many of the groups surveyed, which included electricity providers, battery energy storage vendors, regulators, consultants, and technology advocates, viewed battery storage as an important technology to enable increased use of renewable energy and as a means to solve power quality and asset utilization issues. There are two versions of the document available, an expanded version (approximately 200 pages, SAND97-1275/2) and a short version (approximately 25 pages, SAND97-1275/1).

  16. Anticipatory precrash restraint sensor feasibility study: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kercel, S.W.; Dress, W.B.

    1995-08-01

    This report explores feasibility of an anticipatory precrash restraint sensor. The foundation principle is the anticipation mechanism found at a primitive level of biological intelligence and originally formalized by the mathematical biologist Robert Rosen. A system based on formal anticipatory principles should significantly outperform conventional technologies. It offers the prospect of high payoff in prevention of death and injury. Sensors and processes are available to provide a good, fast, and inexpensive description of the present dynamical state of the vehicle to the embedded system model in the anticipation engine. The experimental part of this study found that inexpensive radar in a real-world setting does return useful data on target dynamics. The data produced by a radar system can be converted to target dynamical information by good, fast and inexpensive signal-processing techniques. Not only is the anticipatory sensor feasible, but further development under the sponsorship of the National Highway Traffic Safety Administration is necessary and desirable. There are a number of possible lines of follow-on investigation. The level of effort and expected benefits of various alternatives are discussed.

  17. Nuclear feasibility study on thorium fueled PWR core

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Myung Hyun; Woo, Il Tak; Lim, Jae Yong; Ku, Bon Seung; Kim, Jong Chae; Lee, Sang Yun [Kyunghee University, Seoul (Korea)

    1999-04-01

    A computer code system, HELIOS and NESTLE or MASTER was established and checked for its reliability for the calculation of thorium fueled reactor. Previous results for the thorium fuel applications were evaluated including RTR reactor concept. Based on the detailed analysis on RTR, a new design concept was proposed. Characteristics of designed core should be checked for conversion ratio, nuclear design feasibility, proliferation resistance, fuel cycle economics, thermal-hydraulic safety, etc. Research was done only for the nuclear feasibility and high conversion in this 1st year. In order to seek for the design methodology, parametric studies were done for the following design parameters-fuel pin size, seed/blanket ratio, fuel material composition, and fissile enrichment. An optimization was done based on once-through fuel cycle with UO{sub 2} seed and (U, Th)O{sub 2} blanket. Economics, safety, non-proliferation, and waste transmutation will be checked in the future research works. (author). 19 refs., 39 figs., 39 tabs.

  18. A feasibility study for a manufacturing technology deployment center

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-31

    The Automation & Robotics Research Institute (ARRI) and the Texas Engineering Extension Service (TEEX) were funded by the U.S. Department of Energy to determine the feasibility of a regional industrial technology institute to be located at the Superconducting Super Collider (SSC) Central Facility in Waxahachie, Texas. In response to this opportunity, ARRI and TEEX teamed with the DOE Kansas City Plant (managed by Allied Signal, Inc.), Los Alamos National Laboratory (managed by the University of California), Vought Aircraft Company, National Center for Manufacturing Sciences (NCMS), SSC Laboratory, KPMG Peat Marwick, Dallas County Community College, Navarro Community College, Texas Department of Commerce (TDOC), Texas Manufacturing Assistance Center (TMAC), Oklahoma Center for the Advancement of Science and Technology, Arkansas Science and Technology Authority, Louisiana Productivity Center, and the NASA Mid-Continent Technology Transfer Center (MCTTC) to develop a series of options, perform the feasibility analysis and secure industrial reviews of the selected concepts. The final report for this study is presented in three sections: Executive Summary, Business Plan, and Technical Plan. The results from the analysis of the proposed concept support the recommendation of creating a regional technology alliance formed by the states of Texas, New Mexico, Oklahoma, Arkansas and Louisiana through the conversion of the SSC Central facility into a Manufacturing Technology Deployment Center (MTDC).

  19. FEASIBILITY STUDY OF SEDIMENT FLUSHING FROM MOSUL RESERVOIR, IRAQ

    Directory of Open Access Journals (Sweden)

    Thair Mahmood Al-Taiee

    2015-02-01

    Full Text Available The Feasibility of sediment flushing  from Mosul reservoir located northern iraq was conducted. Many up to date world criteria and indices for checking the efficiency of sediment flushing from reservoir which have been got through analyzing large amount of  data from many flushed reservoirs  in the world which were depended tested and applied in the present case study (Mosul Reservoir. These criteria and indices depend mainly on the hydrological , hydraulic and  topographical properties of the reservoirs in-addition to the operation plan of the reservoirs. They gave a good indication for checking the efficiency of the sediment flushing  process in the reservoirs. It was concluded that approximately the main criteria for the successful flushing sediment was  verified  in  Mosul  reservoir  such as  Sediment Balance Ratio   (SBR and the Long Term Capacity Ratio (LTCR,the shape factor  of reservoir (W/L and the hydraulic condition such as the percentage of (Qf/Qin and (Vf/Vin. This gave an indication that the processes of flushing sediment in Mosul reservoir is probably feasible and may be applied  in the future to maintain the water storage in the reservoir.

  20. Feasibility of Proton Beam Therapy for Ocular Melanoma Using a Novel 3D Treatment Planning Technique

    Energy Technology Data Exchange (ETDEWEB)

    Hartsell, William F., E-mail: whartsell@chicagocancer.org [Northwestern Medicine Chicago Proton Center, Proton Collaborative Group, Warrenville, Illinois (United States); Kapur, Rashmi [Retina Consultants, Des Plaines, Illinois (United States); Hartsell, Siobhan O' Connor; Sweeney, Patrick [Northwestern Medicine Chicago Proton Center, Warrenville, Illinois (United States); Lopes, Caitlin [Rush Medical College, Chicago, Illinois (United States); Duggal, Amanda [Northwestern Medicine Chicago Proton Center, Warrenville, Illinois (United States); Cohen, Jack [Department of Ophthalmology, Rush University, Chicago, Illinois (United States); Chang, John [Northwestern Medicine Chicago Proton Center, Proton Collaborative Group, Warrenville, Illinois (United States); Polasani, Rajeev S. [Northwestern Medicine Central DuPage Hospital, Winfield, Illinois (United States); Dunn, Megan [Northwestern Medicine Chicago Proton Center, Proton Collaborative Group, Warrenville, Illinois (United States); Pankuch, Mark [Northwestern Medicine Chicago Proton Center, Proton Collaborative Group, Warrenville, Illinois (United States)

    2016-05-01

    Purpose: We evaluated sparing of normal structures using 3-dimensional (3D) treatment planning for proton therapy of ocular melanomas. Methods and Materials: We evaluated 26 consecutive patients with choroidal melanomas on a prospective registry. Ophthalmologic work-up included fundoscopic photographs, fluorescein angiography, ultrasonographic evaluation of tumor dimensions, and magnetic resonance imaging of orbits. Three tantalum clips were placed as fiducial markers to confirm eye position for treatment. Macula, fovea, optic disc, optic nerve, ciliary body, lacrimal gland, lens, and gross tumor volume were contoured on treatment planning compute tomography scans. 3D treatment planning was performed using noncoplanar field arrangements. Patients were typically treated with 3 fields, with at least 95% of planning target volume receiving 50 GyRBE in 5 fractions. Results: Tumor stage was T1a in 10 patients, T2a in 10 patients, T2b in 1 patient, T3a in 2 patients, T3b in 1 patient, and T4a in 2 patients. Acute toxicity was mild. All patients completed treatment as planned. Mean optic nerve dose was 10.1 Gy relative biological effectiveness (RBE). Ciliary body doses were higher for nasal (mean: 11.4 GyRBE) than temporal tumors (5.8 GyRBE). Median follow-up was 31 months (range: 18-40 months). Six patients developed changes which required intraocular bevacizumab or corticosteroid therapy, but only 1 patient developed neovascular glaucoma. Five patients have since died: 1 from metastatic disease and 4 from other causes. Two patients have since required enucleation: 1 due to tumor and 1 due to neovascular glaucoma. Conclusions: 3D treatment planning can be used to obtain appropriate coverage of choroidal melanomas. This technique is feasible with relatively low doses to anterior structures, and appears to have acceptable rates of local control with low risk of enucleation. Further evaluation and follow-up is needed to determine optimal dose-volume relationships for

  1. A behavioral medicine intervention for older women living alone with chronic pain – a feasibility study

    Directory of Open Access Journals (Sweden)

    Cederbom S

    2014-08-01

    Full Text Available Sara Cederbom,1,2 Elisabeth Rydwik,2,3 Anne Söderlund,2 Eva Denison,2 Kerstin Frändin,1 Petra von Heideken Wågert2 1Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Huddinge, 2School of Health, Care and Social Welfare, Mälardalen University, Eskilstuna, Vasteras, 3Research and Development Unit, Jakobsbergs Hospital, Stockholm County Council, Järfälla, Sweden Background: To be an older woman, live alone, have chronic pain, and be dependent on support are all factors that may have an impact on daily life. One way to promote ability in everyday activities in people with pain-related conditions is to use individualized, integrated behavioral medicine in physical therapy interventions. How this kind of intervention works for older women living alone at home, with chronic pain, and dependent on formal care to manage their everyday lives has not been studied. The aim was to explore the feasibility of a study and to evaluate an individually tailored integrated behavioral medicine in physical therapy intervention for the target group of women.Materials and methods: The study was a 12-week randomized trial with two-group design. Primary effect outcomes were pain-related disability and morale. Secondary effect outcomes focused on pain-related beliefs, self-efficacy for exercise, concerns of falling, physical activity, and physical performance.Results: In total, 23 women agreed to participate in the study and 16 women completed the intervention. The results showed that the behavioral medicine in physical therapy intervention was feasible. No effects were seen on the primary effect outcomes. The experimental intervention seemed to improve the level of physical activity and self-efficacy for exercise. Some of the participants in both groups perceived that they could manage their everyday life in a better way after participation in the study.Conclusion: Results from this study are encouraging, but

  2. Slaughterhouse sewage treatment using gamma radiation - economical feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Melo, Rita; Botelho, M. Luisa [Instituto Tecnologico e Nuclear, Sacavem (Portugal). Dept. de Fisica]. E-mail: ritamelo@itn.pt; mlb@itn.pt; Branco, Joaquim [Instituto Tecnologico e Nuclear, Sacavem (Portugal). Dept. de Quimica]. E-mail: jbranco@itn.pt

    2005-07-01

    This paper presents preliminary results of a financial viability study for the implementation of gamma radiation technology on a slaughterhouse wastewater treatment industry. Five scenarios were studied, including the current practice, representing different types of treatments and goals, e.g.: water reuse and/or sludge add value as agriculture fertilizers. Cost-benefit analysis, including the net present value (NPV) of each scenario, was used as a technique to compare the relative value of various strategies. Taking in account that the initial investment is amortized after 20 years, the implementation of Co-60 treatment with 20% water reuse and sludge application as agriculture fertilizers represents the most profitable project with the highest NPV. Therefore, the implementation of gamma radiation technology on a slaughterhouse wastewater treatment industry is not only technically viable as well as economically feasible. (author)

  3. Feasibility Study for an Asymmetric B Factory Based on PEP

    Energy Technology Data Exchange (ETDEWEB)

    Chattapadhyay, A.; Hitlin, D.; Porter, F.; Chin, Y.H.; Dell' Orco, D.; Forest, E.; Furman, M.; Garren, A.A.; Hoyer, E.; Kennedy, K.; Lambertson, G.; Lo, C.C.; Nishimura, H.; Oddone, P.; Ronan, M.; Sessler, A.; Taylor, B.; Taylor, C.; Zisman, M.; Barletta, W.; Allen, M.; Bloom, E.; Burke, D.; Cornacchia, M.; Davies-White, D.; Destaebler, H.; Donald, M.H.; Dorfan, J.; Feldman, G.; Rees, J.; Schsarz, H.; Sullivan, M.; Autin, B.; Tennyson, J.; Barbson, B.; Oide, K.

    1989-10-26

    This report addresses the feasibility of designing and constructing an asymmetric B-factory based on the PEP storage ring at SLAC that can ultimately reach a luminosity of 1 X 10{sup 34} cm{sup -2}s{sup -1}. Such a facility, operating at the {gamma}(4S) resonance, could be used to study mixing, rate decays, and CP violation in the B{bar B} system, and could also study tau and charm physics. The essential accelerator physics, engineering, and technology issues that must be addressed to successfully build this exciting and challenging facility are identified, and possible solutions, or R and D that will reasonable lead to such solutions, are described.

  4. Fuel assembly assessment from CVD image analysis: A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Lindsay, C.S.; Lindblad, T. [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Physics

    1997-05-01

    The Swedish Nuclear Inspectorate commissioned a feasibility study of automatic assessment of fuel assemblies from images obtained with the digital Cerenkov viewing device currently in development. The goal is to assist the IAEA inspectors in evaluating the fuel since they typically have only a few seconds to inspect an assembly. We report results here in two main areas: Investigation of basic image processing and recognition techniques needed to enhance the images and find the assembly in the image; Study of the properties of the distributions of light from the assemblies to determine whether they provide unique signatures for different burn-up and cooling times for real fuel or indicate presence of non-fuel. 8 refs, 27 figs.

  5. Initial Feasibility Study to Drill and Core the Ocean Mantle

    Directory of Open Access Journals (Sweden)

    Nicolas Pilisi

    2011-09-01

    Full Text Available An initial feasibility study (Pilisi and Whitney, 2011 of drilling through the Mohorovičić discontinuity (Moho into the oceanic mantle specifically focused on future requirements for planning, drilling and coring a hole 500 m into the oceanic mantle from three candidate locations in the Pacific Ocean (Cocos Plate, Baja California, and offshore Hawaii. The study points out some of the critical issues that need to be resolved before embarking upon such a challengingproject. It was conducted on the basis of data provided by the Integrated Ocean Drilling Program–Management International (IODP-MI, the Center for Deep Earth Exploration (CDEX operating the drilling vessel Chikyu within IODP, public domain information, and past experience that Blade Energy Partners (hereafter mentioned as “Blade”; http://www.blade-energy.com/ has had with frontier projects in the offshore deepwater oil and gas and geothermal industries.

  6. 76 FR 71601 - Record of Decision, Long Walk National Historic Trail Feasibility Study/Abbreviated Final...

    Science.gov (United States)

    2011-11-18

    ... National Park Service Record of Decision, Long Walk National Historic Trail Feasibility Study/Abbreviated... Environmental Impact Statement for the Long Walk National Historic Trail Feasibility Study. SUMMARY: Pursuant to... Statement for the Long Walk National Historic Trail Feasibility Study, prepared by National Trails...

  7. Feasibility of breathing-adapted PET/CT imaging for radiation therapy of Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Aznar, M C; Andersen, Flemming; Berthelsen, A K

    2011-01-01

    reconstructed with a TrueX algorithm (point spread function, 3 iterations 21 subsets, 2-mm full width half maximum Gaussian filtering). Active areas of uptake were delineated using automatic thresholds of 40% and 50% of maximum standardized uptake value (SUVmax).  Results: SUVmax is on average 20% higher......Aim: Respiration can induce artifacts in positron emission tomography (PET)/computed tomography (CT) images leading to uncertainties in tumour volume, location and uptake quantification. Respiratory gating for PET images is now established but is not directly translatable to a radiotherapy setup....... We investigate the feasibility of introducing a deep inspiration breath hold (DIBH) strategy in PET/CT imaging of Hodgkin lymphoma patients and its impact on image quantification parameters.  Methods: Three patients with suspicion of large mediastinal tumour burden were selected for this study...

  8. Feasibility of breathing-adapted PET/CT imaging for radiation therapy of Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Aznar, M C; Andersen, Flemming; Berthelsen, A K

    2011-01-01

    reconstructed with a TrueX algorithm (point spread function, 3 iterations 21 subsets, 2-mm full width half maximum Gaussian filtering). Active areas of uptake were delineated using automatic thresholds of 40% and 50% of maximum standardized uptake value (SUVmax). Results: SUVmax is on average 20% higher in DIBH......Aim: Respiration can induce artifacts in positron emission tomography (PET)/computed tomography (CT) images leading to uncertainties in tumour volume, location and uptake quantification. Respiratory gating for PET images is now established but is not directly translatable to a radiotherapy setup....... We investigate the feasibility of introducing a deep inspiration breath hold (DIBH) strategy in PET/CT imaging of Hodgkin lymphoma patients and its impact on image quantification parameters. Methods: Three patients with suspicion of large mediastinal tumour burden were selected for this study...

  9. Direct solar pumping of semiconductor lasers: A feasibility study

    Science.gov (United States)

    Anderson, Neal G.

    1992-01-01

    This report describes results of NASA Grant NAG-1-1148, entitled Direct Solar Pumping of Semiconductor Lasers: A Feasibility Study. The goals of this study were to provide a preliminary assessment of the feasibility of pumping semiconductor lasers in space with directly focused sunlight and to identify semiconductor laser structures expected to operate at the lowest possible focusing intensities. It should be emphasized that the structures under consideration would provide direct optical-to-optical conversion of sunlight into laser light in a single crystal, in contrast to a configuration consisting of a solar cell or storage battery electrically pumping a current injection laser. With external modulation, such lasers could perhaps be efficient sources for intersatellite communications. We proposed specifically to develop a theoretical model of semiconductor quantum-well lasers photopumped by a broadband source, test it against existing experimental data where possible, and apply it to estimating solar pumping requirements and identifying optimum structures for operation at low pump intensities. These tasks have been accomplished, as described in this report of our completed project. The report is organized as follows: Some general considerations relevant to the solar-pumped semiconductor laser problem are discussed in Section 2, and the types of structures chosen for specific investigation are described. The details of the laser model we developed for this work are then outlined in Section 3. In Section 4, results of our study are presented, including designs for optimum lattice-matched and strained-layer solar-pumped quantum-well lasers and threshold pumping estimates for these structures. It was hoped at the outset of this work that structures could be identified which could be expected to operate continuously at solar photoexcitation intensities of several thousand suns, and this indeed turned out to be the case as described in this section. Our project is

  10. A pilot RCT of psychodynamic group art therapy for patients in acute psychotic episodes: feasibility, impact on symptoms and mentalising capacity.

    Science.gov (United States)

    Montag, Christiane; Haase, Laura; Seidel, Dorothea; Bayerl, Martin; Gallinat, Jürgen; Herrmann, Uwe; Dannecker, Karin

    2014-01-01

    This pilot study aimed to evaluate the feasibility of an assessor-blind, randomised controlled trial of psychodynamic art therapy for the treatment of patients with schizophrenia, and to generate preliminary data on the efficacy of this intervention during acute psychotic episodes. Fifty-eight inpatients with DSM-diagnoses of schizophrenia were randomised to either 12 twice-weekly sessions of psychodynamic group art therapy plus treatment as usual or to standard treatment alone. Primary outcome criteria were positive and negative psychotic and depressive symptoms as well as global assessment of functioning. Secondary outcomes were mentalising function, estimated with the Reading the mind in the eyes test and the Levels of emotional awareness scale, self-efficacy, locus of control, quality of life and satisfaction with care. Assessments were made at baseline, at post-treatment and at 12 weeks' follow-up. At 12 weeks, 55% of patients randomised to art therapy, and 66% of patients receiving treatment as usual were examined. In the per-protocol sample, art therapy was associated with a significantly greater mean reduction of positive symptoms and improved psychosocial functioning at post-treatment and follow-up, and with a greater mean reduction of negative symptoms at follow-up compared to standard treatment. The significant reduction of positive symptoms at post-treatment was maintained in an attempted intention-to-treat analysis. There were no group differences regarding depressive symptoms. Of secondary outcome parameters, patients in the art therapy group showed a significant improvement in levels of emotional awareness, and particularly in their ability to reflect about others' emotional mental states. This is one of the first randomised controlled trials on psychodynamic group art therapy for patients with acute psychotic episodes receiving hospital treatment. Results prove the feasibility of trials on art therapy during acute psychotic episodes and justify

  11. A pilot RCT of psychodynamic group art therapy for patients in acute psychotic episodes: feasibility, impact on symptoms and mentalising capacity.

    Directory of Open Access Journals (Sweden)

    Christiane Montag

    Full Text Available This pilot study aimed to evaluate the feasibility of an assessor-blind, randomised controlled trial of psychodynamic art therapy for the treatment of patients with schizophrenia, and to generate preliminary data on the efficacy of this intervention during acute psychotic episodes. Fifty-eight inpatients with DSM-diagnoses of schizophrenia were randomised to either 12 twice-weekly sessions of psychodynamic group art therapy plus treatment as usual or to standard treatment alone. Primary outcome criteria were positive and negative psychotic and depressive symptoms as well as global assessment of functioning. Secondary outcomes were mentalising function, estimated with the Reading the mind in the eyes test and the Levels of emotional awareness scale, self-efficacy, locus of control, quality of life and satisfaction with care. Assessments were made at baseline, at post-treatment and at 12 weeks' follow-up. At 12 weeks, 55% of patients randomised to art therapy, and 66% of patients receiving treatment as usual were examined. In the per-protocol sample, art therapy was associated with a significantly greater mean reduction of positive symptoms and improved psychosocial functioning at post-treatment and follow-up, and with a greater mean reduction of negative symptoms at follow-up compared to standard treatment. The significant reduction of positive symptoms at post-treatment was maintained in an attempted intention-to-treat analysis. There were no group differences regarding depressive symptoms. Of secondary outcome parameters, patients in the art therapy group showed a significant improvement in levels of emotional awareness, and particularly in their ability to reflect about others' emotional mental states. This is one of the first randomised controlled trials on psychodynamic group art therapy for patients with acute psychotic episodes receiving hospital treatment. Results prove the feasibility of trials on art therapy during acute psychotic

  12. Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans.

    Science.gov (United States)

    Seebach, Caroline; Henrich, Dirk; Meier, Simon; Nau, Christoph; Bonig, Halvard; Marzi, Ingo

    2016-11-15

    Local implantation of ex vivo concentrated, washed and filtrated human bone marrow-derived mononuclear cells (BMC) seeded onto β-tricalciumphosphate (TCP) significantly enhanced bone healing in a preclinical segmental defect model. Based on these results, we evaluated in a first clinical phase-I trial safety and feasibility of augmentation with preoperatively isolated autologous BMC seeded onto β-TCP in combination with angle stable plate fixation for the therapy of proximal humeral fractures as a potential alternative to autologous bone graft from the iliac crest. 10 patients were enrolled to assess whether cell therapy with 1.3 × 106 autologous BMC/ml/ml β-TCP, collected on the day preceding the definitive surgery, is safe and feasible when seeded onto β-TCP in patients with a proximal humeral fracture. 5 follow-up visits for clinical and radiological controls up to 12 weeks were performed. β-tricalciumphosphate fortification with BMC was feasible and safe; specifically, neither morbidity at the harvest site nor at the surgical wound site were observed. Neither local nor systemic inflammation was noted. All fractures healed within the observation time without secondary dislocation. Three adverse events were reported: one case each of abdominal wall shingles, tendon loosening and initial screw perforation, none of which presumed related to the IND. Cell therapy with autologous BMC for bone regeneration appeared to be safe and feasible with no drug-related adverse reactions being described to date. The impression of efficacy was given, although the study was not powered nor controlled to detect such. A clinical trial phase-II will be forthcoming in order to formally test the clinical benefit of BMC-laden β-TCP for PHF patients. Trial registration The study was registered in the European Clinical Trial Register as EudraCT No. 2012-004037-17. Date of registration 30th of August 2012. Informed consent was signed from all patients enrolled.

  13. Proton therapy posterior beam approach with pencil beam scanning for esophageal cancer. Clinical outcome, dosimetry, and feasibility

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Yue-Can [Shengjing Hospital of China Medical University, Department of Medical Oncology, Cancer Center, Shenyang (China); University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); Vyas, Shilpa; Apisarnthanarax, Smith; Zeng, Jing [University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); Dang, Quang; Schultz, Lindsay [Seattle Cancer Care Alliance Proton Therapy Center, Seattle, WA (United States); Bowen, Stephen R. [University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); University of Washington Medical Center, Department of Radiology, Seattle, WA (United States); Shankaran, Veena [University of Washington Medical Center, Department of Medical Oncology, Seattle, WA (United States); Farjah, Farhood [University of Washington Medical Center, Department of Surgery, Division of Cardiothoracic Surgery, Seattle, WA (United States); University of Washington Medical Center, Department of Surgery, Surgical Outcomes Research Center, Seattle, WA (United States); Oelschlager, Brant K. [University of Washington Medical Center, Department of Surgery, Seattle, WA (United States)

    2016-12-15

    The aim of this study is to present the dosimetry, feasibility, and preliminary clinical results of a novel pencil beam scanning (PBS) posterior beam technique of proton treatment for esophageal cancer in the setting of trimodality therapy. From February 2014 to June 2015, 13 patients with locally advanced esophageal cancer (T3-4N0-2M0; 11 adenocarcinoma, 2 squamous cell carcinoma) were treated with trimodality therapy (neoadjuvant chemoradiation followed by esophagectomy). Eight patients were treated with uniform scanning (US) and 5 patients were treated with a single posterior-anterior (PA) beam PBS technique with volumetric rescanning for motion mitigation. Comparison planning with PBS was performed using three plans: AP/PA beam arrangement; PA plus left posterior oblique (LPO) beams, and a single PA beam. Patient outcomes, including pathologic response and toxicity, were evaluated. All 13 patients completed chemoradiation to 50.4 Gy (relative biological effectiveness, RBE) and 12 patients underwent surgery. All 12 surgical patients had an R0 resection and pathologic complete response was seen in 25 %. Compared with AP/PA plans, PA plans have a lower mean heart (14.10 vs. 24.49 Gy, P < 0.01), mean stomach (22.95 vs. 31.33 Gy, P = 0.038), and mean liver dose (3.79 vs. 5.75 Gy, P = 0.004). Compared to the PA/LPO plan, the PA plan reduced the lung dose: mean lung dose (4.96 vs. 7.15 Gy, P = 0.020) and percentage volume of lung receiving 20 Gy (V{sub 20}; 10 vs. 17 %, P < 0.01). Proton therapy with a single PA beam PBS technique for preoperative treatment of esophageal cancer appears safe and feasible. (orig.) [German] Wir stellen die Vergleichsdosimetrie, Realisierbarkeit und die vorlaeufigen klinischen Ergebnisse einer neuen Pencil-Beam-Scanning(-PBS)/Posterior-Beam-Methode innerhalb der Protonentherapie fuer Speiseroehrenkrebs im Setting einer trimodalen Therapie vor. Von Februar 2014 bis Juni 2015 erhielten 13 Patienten mit lokal fortgeschrittenem

  14. Screening for depression in older district nursing clients: feasibility study.

    Science.gov (United States)

    Nunn, Russell; Annells, Merilyn; Sims, Jane

    2007-03-01

    Depression is a common condition among older district nursing clients. This two-cycle feasibility study trialled a process for depression screening by using the 15-item Geriatric Depression Scale (GDS) with a sample of older clients in an Australian district nursing organization. An education session about depression and use of the GDS preceded the screening process. The trial found that a number of barriers existed among participant nurses regarding screening for depression, although generally they acknowledged depression as a common problem among older clients and most believed that they potentially had a important role in the identification and support of clients with this condition. Lack of knowledge emerged as a major constraint, as did uneasiness about entering the mental health area, with some reluctance to use the GDS because of the type of questions included and not wanting to be intrusive regarding the 'emotional matters' of clients. Recommendations are offered about screening for depression with this client population.

  15. Robot-assisted endoscopic intrauterine myelomeningocele repair: a feasibility study.

    Science.gov (United States)

    Aaronson, Oran S; Tulipan, Noel B; Cywes, Robert; Sundell, Håkan W; Davis, Georges H; Bruner, Joseph P; Richards, William O

    2002-02-01

    Animal experiments have suggested that the intrauterine environment causes secondary injury to the congenitally dysplastic spinal cord. This in turn suggests that early closure of the myelomeningocele sac might prevent secondary injury and therefore improve neurologic outcome. This study was designed to examine the technical feasibility of performing intrauterine myelomeningocele repair using a robot-assisted endoscopic system in an animal model. Six fetal sheep underwent creation and repair of a full-thickness skin lesion using the da Vinci system. With the device's advanced articulated instruments and three-dimensional optics, it was possible to endoscopically repair the induced skin defects. We conclude that, with the recent evolution in robotics and minimally invasive techniques, intrauterine endoscopic surgery has become a realistic goal that promises to reduce the associated risks of fetal surgery and extend the indications for its use. Copyright 2002 S. Karger AG, Basel

  16. Cherokee Wind Energy Development - Feasibility and Pre-Construction Studies

    Energy Technology Data Exchange (ETDEWEB)

    McMillan, Andy [Cherokee Nation Businesses, LLC, Catoosa, OK (United States)

    2017-06-30

    Cherokee Nation Businesses (CNB) received a grant from the US Department of Energy to explore feasibility and pursue development of a wind power generation facility on Cherokee land in north-central Oklahoma. This project followed several years of initial study exploring the possibility of commercial-scale wind power generation on primarily agricultural land owned by the Cherokee Nation. This project produced detailed analysis of the legal, financial and market viability of such generation facilities, and encompassed a full technical evaluation of the engineering, environmental, and geotechnical aspects of installing this capacity. During the course of this project, information gleaned from this exploration changed CNB’s thinking about the best course of action for Cherokee participation in the development, eventually moving away from an equity-owner model and towards utilization of the land asset as a resource while mitigating Cherokee financial and operational risk.

  17. Feasibility studies for a wireless 60 GHz tracking detector readout

    CERN Document Server

    Dittmeier, Sebastian; Soltveit, Hans Kristian; Wiedner, Dirk

    2016-01-01

    The amount of data produced by highly granular silicon tracking detectors in high energy physics experiments poses a major challenge to readout systems. At high collision rates, e.g. at LHC experiments, only a small fraction of data can be read out with currently used technologies. To cope with the requirements of future or upgraded experiments new data transfer techniques are required which offer high data rates at low power and low material budget. Wireless technologies operating in the 60 GHz band or at higher frequencies offer high data rates and are thus a promising upcoming alternative to conventional data transmission via electrical cables or optical fibers. Using wireless technology, the amount of cables and connectors in detectors can be significantly reduced. Tracking detectors profit most from a reduced material budget as fewer secondary particle interactions (multiple Coulomb scattering, energy loss, etc.) improve the tracking performance in general. We present feasibility studies regarding the in...

  18. Microwave Sanitization of Color Additives Used in Cosmetics: Feasibility Study

    Science.gov (United States)

    Jasnow, S. B.; Smith, J. L.

    1975-01-01

    Microwave exposure has been explored as a method of microbiologically sanitizing color additives used in cosmetic products. Selected microbiologically unacceptable cosmetic color additives, D&C red no. 7 Ca lake (certified synthetic organic color), carmine (natural organic color not subject to certification), and chromium hydroxide green (inorganic color not subject to certification), were submitted to microwave exposure. Gram-negative bacteria were eliminated, as verified by enrichment procedures, and levels of gram-positive bacteria were reduced. Generally, analytical and dermal safety studies indicated no significant alterations in physical, chemical, and toxicological properties of the colors. Sanitization was also successfully performed on other colors (D&C red no. 9 Ba lake, D&C red no. 12 Ba lake, D&C green no. 5, and FD&C red no. 4); initial physical and chemical tests were satisfactory. Results indicated that this method of sanitization is feasible and warrants further investigation. PMID:1164010

  19. Feasibility Study on Nuclear Propulsion Ship according to Economic Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Gil, Youngmi; Yoo, Seongjin; Oh, June; Byun, Yoonchul; Woo, Ilguk [Daewoo Shipbuilding and Marine Engineering Co., Ltd, Seoul (Korea, Republic of); Kim, Jiho; Choi, Suhn [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    The use of nuclear ships has been extending to the icebreaker, the deep-water exploration ship, and the floating nuclear power plant. Prior to developing the new ship, the relevant regulations need to be considered. In this study, we reviewed the nuclear ship-related regulations. In addition, economic value is one of the most important factors which should be considered in the pre-design phase. To evaluate the economics of the nuclear ship, we calculated Capital Expenditure (abbreviated as CAPEX) and Operation Expenditure (abbreviated as OPEX) for various types of ships. We reviewed the nuclear ship-related regulations and evaluated the economics of the nuclear ship compared to the diesel ship. The calculation result shows that economic feasibility of the nuclear ship depends on the oil price as well as the cost of the nuclear reactor.

  20. Feasibility Study: Potential Enhancements for the LLNL Renewables Website

    Energy Technology Data Exchange (ETDEWEB)

    Kearns, F; Krawchuk, M; Moritz, M; Stephens, S; Goldstein, N

    2008-01-25

    This feasibility study investigates additional improvements/extensions to the LLNL Renewables Website. Currently, the Renewables Website focuses on wind energy in California. Future enhancements will include other renewable energy sources. The extensions described below are focused along two separate yet related avenues: (1) Forecasting wildfire risk in the regions of California where new development may occur, as a part of the 'Million Solar Roofs' program. (2) Gaining a better understanding of the ecological components and potential of biofuels from forests in California. These two avenues are further described in the report. Following is a technical description of the Center for Fire Research and Outreach computing and web service capabilities.

  1. Feasibility study of an active target for the MEG experiment

    Energy Technology Data Exchange (ETDEWEB)

    Papa, A., E-mail: angela.papa@psi.ch [Paul Scherrer Institut PSI, CH-5232 Villigen (Switzerland); Cavoto, G. [INFN Sezione di Roma, P.le Aldo Moro, 2, 00185 Roma (Italy); Ripiccini, E. [INFN Sezione di Roma, P.le Aldo Moro, 2, 00185 Roma (Italy); Dipartimento di Fisica dell' Università degli studi di Roma, P.le Aldo Moro, 2, 00185 Roma (Italy)

    2014-03-01

    We consider the possibility to have an active target for the upgrade of the MEG experiment (MEG II). The active target should work as (1) a beam monitoring, to continuously measure the muon stopping rate and therefore provide a direct evaluation of the detector acceptance (or an absolute normalization of the stopped muon); and as (2) an auxiliary device for the spectrometer, to improve the determination of the muon decay vertex and consequently to achieve a better positron momentum and angular resolutions, detecting the positron from the muon decay. In this work we studied the feasibility of detecting minimum ionizing particle with a single layer of 250 μm fiber and the capability to discriminate between the signal induced by either a muon or a positron.

  2. A feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone-marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology.

    Science.gov (United States)

    Yamada, Yoichi; Nakamura, Sayaka; Ito, Kenji; Sugito, Takayuki; Yoshimi, Ryoko; Nagasaka, Tetsuro; Ueda, Minoru

    2010-06-01

    This study investigated the effect of bone regeneration with dental pulp stem cells (DPSCs), deciduous tooth stem cells (DTSCs), or bone-marrow-derived mesenchymal stem cells (BMMSCs) for clinical study on hydroxyapatite-coated osseointegrated dental implants, using tissue engineering technology. In vitro, human DPSCs and DTSCs expressed STRO-1, CD13, CD29, CD 44, CD73, and osteogenic marker genes such as alkaline phosphatase, Runx2, and osteocalcin. In vivo, prepared bone defect model was implanted using graft materials as follows: platelet-rich plasma (PRP), PRP and canine BMMSCs (cBMMSCs), PRP and canine DPSCs (cDPSCs), PRP and puppy DTSCs (pDTSCs), and control (defect only). After 8 weeks, the dental implants were installed, and 16 weeks later the sections were evaluated histologically and histometrically. The cBMMSCs/PRP, cDPSCs/PRP, and pDTSCs/PRP groups had well-formed mature bone and neovascularization. Histometrically, the bone-implant contact was significantly different between the cBMMSCs/PRP, cDPSCs/PRP, pDTSCs/PRP groups, and the control and PRP groups (p < 0.01). These results demonstrated that these stem cells with PRP have the ability to form bone, and this bone formation activity might be useful for osseointegrated hydroxyapatite-coated dental implants with good levels of bone-implant contact.

  3. Pilot Feasibility Study of an Oncology Financial Navigation Program.

    Science.gov (United States)

    Shankaran, Veena; Leahy, Tony; Steelquist, Jordan; Watabayashi, Kate; Linden, Hannah; Ramsey, Scott; Schwartz, Naomi; Kreizenbeck, Karma; Nelson, Judy; Balch, Alan; Singleton, Erin; Gallagher, Kathleen; Overstreet, Karen

    2018-02-01

    Few studies have reported on interventions to alleviate financial toxicity in patients with cancer. We developed a financial navigation program in collaboration with our partners, Consumer Education and Training Services (CENTS) and Patient Advocate Foundation (PAF), to improve patient knowledge about treatment costs, provide financial counseling, and to help manage out-of-pocket expenses. We conducted a pilot study to assess the feasibility and impact of this program. Patients with cancer received a financial education course followed by monthly contact with a CENTS financial counselor and a PAF case manager for 6 months. We measured program adherence, self-reported financial burden and anxiety, program satisfaction, and type of assistance provided. Thirty-four patients (median age, 60.5 years) were consented (85% white and 50% commercially insured). Debt, income declines, and loans were reported by 55%, 55%, and 30% of patients, respectively. CENTS counselors assisted most often with budgeting, retirement planning, and medical bill questions. PAF case managers assisted with applications for appropriate insurance coverage, cost of living issues (eg, housing, transportation), and disability applications. High financial burden and anxiety about costs (4 or 5 on a Likert scale) were reported at baseline by 37% and 47% of patients, respectively. Anxiety about costs decreased over time in 33% of patients, whereas self-reported financial burden did not substantially change. Implementing an oncology financial navigation program is feasible, provides concrete assistance in navigating the cost of care, and mitigates anxiety about costs in a subset of patients. Future work will focus on measuring the program's impact on financial and clinical outcomes.

  4. A preliminary feasibility study on natural analogue in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chun Soo; Bae, Dae Seok; Kim, Kyung Su; Koh, Yong Kwon; Park, Byung Yun

    2000-03-01

    Preliminary study on the assessment of natural analogue study in Korea for the deep geological disposal of high-level radioactive waste was carried out. The project on natural analogue study in other countries are introduced. The uranium-bearing deposit in Okcheon belt are summarized, which reported to be uranium-bearing minerals in order to assess to feasibility for natural analogue study in Korea. Among the uranium-bearing deposits, the Deokpyeong area, reported to be the highest reservoir and grade, are selected as the study site, and the elementary investigation, including survey of radioactivity and geochemistry are carried out. According to the investigation of surface environment, the radioactivity and uranium content in the surface water and shallow groundwater does not show any anormal values. However, the radioactivity is expected to be increased in depth and the groundwater reacted with uranium-bearing graphite formation shows high unanium content, indicating the potential possibility for natural analogue study in Korea. In future, if more detail study are performed, the assessment of natural analogue study in Korea are expected.

  5. Feasibility Study on Solar District Heating in China

    DEFF Research Database (Denmark)

    Huang, Junpeng; Fan, Jianhua; Furbo, Simon

    This paper analyzes the feasibility of developing solar district heating (SDH) in China from the perspective of incentive policy, selections of technical route, regional adaptability and economic feasibility for clean heating. Based on the analyzation, this proposes a road map for the development...

  6. Randomized Clinical Trial of Dialectical Behavior Therapy for Preadolescent Children With Disruptive Mood Dysregulation Disorder: Feasibility and Outcomes.

    Science.gov (United States)

    Perepletchikova, Francheska; Nathanson, Donald; Axelrod, Seth R; Merrill, Caitlin; Walker, Amy; Grossman, Meredith; Rebeta, James; Scahill, Lawrence; Kaufman, Joan; Flye, Barbara; Mauer, Elizabeth; Walkup, John

    2017-10-01

    Persistent irritability and behavior outbursts in disruptive mood dysregulation disorder (DMDD) are associated with severe impairment in childhood and with negative adolescent and adult outcomes. There are no empirically established treatments for DMDD. This study examined the feasibility and preliminary efficacy of dialectical behavior therapy adapted for preadolescent children (DBT-C) with DMDD. Children 7 to 12 years old with DMDD (N = 43) were randomly assigned 1:1 to DBT-C or treatment as usual (TAU). The 6 domains of feasibility included recruitment, randomization, retention, attendance, participants' satisfaction, and therapist adherence. Blinded raters assessed participants at baseline, after 8, 16, 24, and 32 weeks, and at 3-month follow-up. The primary efficacy outcome was the positive response rate on the Clinical Global Impression-Improvement scale. Improvements in behavior outbursts and angry/irritable mood were assessed by the Clinical Global Impression-Severity scale. Mean number of participants randomized per month was 2.53 ± 2.72. Participants in DBT-C (n = 21) attended 89% of sessions compared with 48.6% in TAU (n = 22). Eight TAU participants (36.4%) dropped out compared with none in DBT-C. Parents and children in DBT-C expressed significantly higher treatment satisfaction than those in TAU. The rate of positive response was 90.4% in DBT-C compared with 45.5% in TAU, despite 3 times as many participants in TAU receiving psychiatric medications. Remission rates were 52.4% for DBT-C and 27.3% for TAU. Improvements were maintained at 3-month follow-up. Therapists showed adherence to DBT-C. DBT-C demonstrated feasibility in all prespecified domains. Outcomes also indicated preliminary efficacy of DBT-C. Clinical trial registration information-Adapting DBT for Children With DMDD: Pilot RCT; http://clinicaltrials.gov/; NCT01862549. Copyright © 2017 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

  7. Repeated nipple fluid aspiration: compliance and feasibility results from a prospective multicenter study.

    Directory of Open Access Journals (Sweden)

    J S de Groot

    Full Text Available Despite intensive surveillance, a high rate of interval malignancies is still seen in women at increased breast cancer risk. Therefore, novel screening modalities aiming at early detection remain needed. The intraductal approach offers the possibility to directly sample fluid containing cells, DNA and proteins from the mammary ductal system where, in the majority of cases, breast cancer originates. Fluid from the breast can non-invasively be obtained by oxytocin-assisted vacuum aspiration, called nipple fluid aspiration (NFA. The goal of this feasibility study was to evaluate the potential of repeated NFA, which is a critical and essential step to evaluate its possible value as a breast cancer screening method.In this multicenter, prospective study, we annually collected nipple fluid for up to 5 consecutive years from women at increased breast cancer risk, and performed a questionnaire-based survey regarding discomfort of the aspiration. Endpoints of the current interim analyses were the feasibility and results of 994 NFA procedures in 451 women with total follow-up of 560 person years of observation.In this large group of women at increased risk of breast cancer, repetitive NFA appeared to be feasible and safe. In 66.4% of aspirated breasts, nipple fluid was successfully obtained. Independent predictive factors for successful NFA were premenopausal status, spontaneous nipple discharge, smaller breast size, bilateral oophorectomy and previous use of hormone replacement therapy or anti-hormonal treatment. The procedure was well tolerated with low discomfort. Drop-out rate was 20%, which was mainly due to repeated unsuccessful aspiration attempts. Only 1.6% of women prematurely declined further participation because of side effects.Repeated NFA in women at increased breast cancer risk is feasible and safe. Therefore, NFA is a promising method to non-invasively obtain a valuable source of potential breast cancer specific biomarkers.

  8. Istra district heating system. Master plan and feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-01

    This report presents the results of the Feasibility Study of options for improving the efficiency and operating economy of Istra Large-Scale Demonstration Project includes all areas of the town of Istra. However, the Feasibility Study is confined to the five largest adjoining boilers plant areas within the borders of Istra town. The study was conducted from 1999 to 2001 and was based on information collected during this period. The city administration and the district heating company in Istra provided the data. The company RDIEE, Russian Danish Institute for Energy Efficiency, in Istra collected and processed the data under the conduction of Carl Bro a/s in Denmark. The main objectives of the study are to provide the Istra DHC with a number of options for future development of the district heating system based on technical/financial analyses and presenting the best possibilities for improved comfort, operation and business development. More concretely, one or more system improvement scenarios, which can be implemented in the near future as a first step of the recommended medium-term to long-term development, are identified. Another important objective has been to train the specialists of RDIEE in the feasibility study process and to transfer know-how, skills and tools. The model used for this study is adapted to the features and the special problems to be addressed in relation to the Istra district heating system. RDIEE and Istra DHC are thereby provided with a useful tool which may be used for continued study and development after the first phase project has been completed. As usual in the case of input/output models the quality of the results depends very much on the quality of input data. The present report is exclusively based on the consultant's understanding of the provided information. The results and the underlying inputs should be carefully considered before any final decision concerning implementation is taken. Verification of assumptions should also

  9. Therapeutic Argentine Tango Dancing for People with Mild Parkinson's Disease: A Feasibility Study.

    Science.gov (United States)

    Blandy, Laura M; Beevers, Winifred A; Fitzmaurice, Kerry; Morris, Meg E

    2015-01-01

    Individuals living with Parkinson's disease (PD) can experience a range of movement disorders that affect mobility and balance and increase the risk of falls. Low health-related quality of life, depression, and anxiety are more common in people with PD than age-matched comparisons. Therapeutic dance is a form of physical activity believed to facilitate movement and therapy uptake. As well as being enjoyable, dancing is thought to improve mobility, balance, and well-being in some people living with PD. The primary objective of this study was to evaluate the feasibility and safety of a 4-week Argentine tango dance program for people with PD. Six community dwelling individuals with mild to moderate PD were recruited from Parkinson's support groups, movement disorder clinics, and the PD association in Australia. To minimize falls risk, participants were required to be tango dance classes. Physiotherapists were present to assist participants during the class and served as dance partners as necessary. The primary outcome was feasibility, which was determined by measures of recruitment, adherence, attrition, safety (falls, near misses and adverse events), and resource requirements. Secondary measures included the Beck Depression Inventory and the Euroqol-5D, administered at baseline and post intervention. Therapy outcomes pre- and post-intervention were analyzed descriptively as medians and interquartile ranges and using Wilcoxon matched pair signed-rank tests. The Argentine tango dance intervention was shown to be safe, with no adverse events. Adherence to the dance program was 89%. Depression scores improved after intervention (p = 0.04). Some challenges were associated with the need to quickly recruit participants and physiotherapists to act as dance partners during classes and to monitor participants. The 4-week, twice weekly Argentine tango dancing program was shown to be feasible and safe for people with mild-to-moderately severe PD.

  10. Woodbridge Research Facility Remedial investigation/feasibility study: Focused feasibility study for Operable Unit One. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, P.; Huber, K.; Hanson, K.; Stowers, J.; Ehlers, M.

    1997-11-01

    Operable Unit One (OU1) at the Woodbridge Research Facility (WRF) has been defined as the area encompassing AREEs 1 through 6B (former dumps) and AREE 7 (former Pistol Range). A Focused Feasibility Study,, has been conducted to identify and screen remedial alternatives for OU1, to address, contaminated groundwater, surface soil, subsurface soil, and sediment detected at AREEs associated with OU1. This report summarizes the history, current conditions, and environmental data. Human health and ecological risk assessments are presented. General response actions, technology types, and process options appropriate for the remediation of contaminated media are identified. Process options are screened and assembled into five alternatives. Each alternative is evaluated in detail using the nine criteria identified in the NCP (40 CFR 300.430(e)). The report concludes with a comparison, of the remedial options under consideration.

  11. Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy.

    Science.gov (United States)

    Song, Junho; Hynynen, Kullervo

    2010-01-01

    A hemispherical-focused, ultrasound phased array was designed and fabricated using 1372 cylindrical piezoelectric transducers that utilize lateral coupling for noninvasive transcranial therapy. The cylindrical transducers allowed the electrical impedance to be reduced by at least an order of magnitude, such that effective operation could be achieved without electronic matching circuits. In addition, the transducer elements generated the maximum acoustic average surface intensity of 27 W/cm(2). The array, driven at the low (306-kHz) or high frequency (840-kHz), achieved excellent focusing through an ex vivo human skull and an adequate beam steering range for clinical brain treatments. It could electronically steer the ultrasound beam over cylindrical volumes of 100-mm in diameter and 60-mm in height at 306 kHz, and 30-mm in diameter and 30-mm in height at 840 kHz. A scanning laser vibrometer was used to investigate the radial and length mode vibrations of the element. The maximum pressure amplitudes through the skull at the geometric focus were predicted to be 5.5 MPa at 306 kHz and 3.7 MPa at 840 kHz for RF power of 1 W on each element. This is the first study demonstrating the feasibility of using cylindrical transducer elements and lateral coupling in construction of ultrasound phased arrays.

  12. Cognitive behavioral therapy for insomnia comorbid with COPD is feasible with preliminary evidence of positive sleep and fatigue effects

    Directory of Open Access Journals (Sweden)

    Kapella MC

    2011-11-01

    Full Text Available Mary C Kapella1, James J Herdegen2, Michael L Perlis3, Joan L Shaver4, Janet L Larson5, Julie A Law2, David W Carley11Center for Narcolepsy, Sleep and Health Research, Department of Biobehavioral Science, College of Nursing, 2Section of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; 3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA; 4College of Nursing, University of Arizona, Tucson, AZ, USA; 5Division of Acute, Critical and Long Term Care Programs, University of Michigan School of Nursing, Ann Arbor, MI, USABackground: Many people with COPD report difficulties falling asleep or staying asleep, insufficient sleep duration, or nonrestorative sleep. Cognitive behavioral therapy for insomnia (CBT-I has proved effective not only in people with primary insomnia but also in people with insomnia comorbid with psychiatric and medical illness (eg, depression, cancer, and chronic pain. However, CBT-I has rarely been tested in those with COPD who have disease-related features that interfere with sleep and may lessen the effectiveness of such therapies. The purpose of this study was to determine the feasibility of applying a CBT-I intervention for people with COPD and to assess the impact of CBT-I on insomnia severity and sleep-related outcomes, fatigue, mood, and daytime functioning.Methods: The study had two phases. In Phase 1, a 6-weekly session CBT-I intervention protocol in participants with COPD was assessed to examine feasibility and acceptability. Phase 2 was a small trial utilizing a prospective two-group pre- and post-test design with random assignment to the six-session CBT-I or a six-session wellness education (WE program to determine the effects of each intervention, with both interventions being provided by a nurse behavioral sleep medicine specialist.Results: Fourteen participants (five in Phase 1 and nine in Phase 2 completed six sessions of

  13. Musculoskeletal ultrasound in internal medicine residency – a feasibility study

    Directory of Open Access Journals (Sweden)

    Gaurav Gulati

    2015-06-01

    Full Text Available Introduction: Ultrasound has become indispensable in medicine for diagnosis and therapeutics. In Internal Medicine Residency Training Program (IMRTP, there is a deficiency of a structured, competency-based musculoskeletal ultrasound (MSKUS training despite its growing popularity. Methods: We conducted a feasibility study for incorporating MSKUS in IMRTP and competency assessment. We recruited internal medicine residents from all training levels. Rheumatology attending with expertise in MSKUS supervised curriculum-design and patient-based assessment. A structured curriculum was developed for knee MSKUS, including training material and a pre- and post-test. An Observed Structured Clinical Exam (OSCE was used for competency assessment. Attending evaluations and participant feedbacks were collected. Results: Fifteen residents participated and 12 completed the OSCE. The pre–post tests showed a statistically significant increase (p<0.001 for all subcomponents (anatomy, pathology, and biophysics. The residents scored high on the OSCE [8.8±1.1 (range 7–10]. Attending evaluations for cognitive and technical skills were rated ‘Excellent’ (66% and ‘Good’ (87%, respectively. The training program was perceived very valuable with regard to time and resources spent by residents and faculty, although some felt a need for more patient assessments. Discussion: The competency assessed with our OSCE and highly positive feedback reflects this preliminary study's importance and sets the platform for future studies of formal ultrasound training in internal medicine.

  14. Feasibility study of submarine diesel exhaust valve interspace coating application

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, W.; Zhou, M.; Bibby, D.; Huang, J.

    2008-05-15

    This document described a feasibility study conducted to evaluate surface coating systems applied to the surface of a diesel exhaust valve interspace on a VICTORIA Class submarine. A series of laboratory studies were conducted to determine the physical characteristics of the coatings, which will be subjected to high service temperatures, diesel exhaust gas, and seawater. The valves were made of Q1N steel castings. The surface coatings were designed to provide corrosion resistance and thermal protection to the valves. As part of the study, a survey was conducted on various state-of-the-art surface coating systems. Coatings were rated on their ability to protect the Q10 steel surface from corrosion, high temperatures and seawater. An additional requirement was that the coatings should not produce high amounts of hydrogen. Plating trials were conducted with a nickel-based alloy (Ni-Cu-P) placed on Q1N steel substrates with a hypophosphite reducing agent. The results of X-ray diffraction (XRD) analyses suggested that the coatings can also be used to protect the external surfaces of various submarine components. 54 refs., 4 tabs., 10 figs.

  15. Quantification of manganese in human hand bones: a feasibility study

    Science.gov (United States)

    Aslam; Pejović-Milić, A.; Chettle, D. R.; McNeill, F. E.

    2008-08-01

    Manganese is both an essential element to human health and also toxic when humans are exposed to excessive levels, particularly by means of inhalation. Biological monitoring of manganese exposure is problematic. It is subject to homeostasis; levels in blood (or serum/plasma) reflect only the most recent exposure and rapidly return to within normal ranges, even when there has been a temporary excursion in response to exposure. In this context, we have been developing a non-invasive technique for measurement of manganese stored in bone, using in vivo neutron activation analysis. Following preliminary feasibility studies, the technique has been enhanced by two significant infrastructure advances. A specially designed irradiation facility serves to maximize the activation of manganese with respect to the dose of ionizing radiation. Secondly, an array of eight NaI(Tl) crystals provides a detection system with very close to 4π geometry. This feasibility study, using neutron activation analysis to measure manganese in the bones of the hand, takes two features into account. Firstly, there is considerable magnesium present in the bone and this produces a spectral interference with the manganese. The 26Mg(n,γ)27Mg reaction produces γ-rays of 0.843 MeV from the decay of 27Mg, which interfere with the 0.847 MeV γ-rays from the decay of 56Mn, produced by the 55Mn(n,γ)56Mn reaction. Secondly, this work provides estimates of the levels of manganese to be expected in referent subjects. A revised estimate has been made from the most recent literature to explore the potential of the technique as a suitable means of screening patients and people exposed to excessive amounts of Mn who could develop many-fold increased levels of Mn in bones as demonstrated through various animal studies. This report presents the enhancements to the neutron activation system, by which manganese can be measured, which resulted in a detection limit in the hand of human subjects of 1.6 µg/g Ca. It

  16. Quantification of manganese in human hand bones: a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Aslam; Pejovic-Milic, A; Chettle, D R; McNeill, F E [Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, L8S 4K1 (Canada)], E-mail: aslamib@mcmaster.ca

    2008-08-07

    Manganese is both an essential element to human health and also toxic when humans are exposed to excessive levels, particularly by means of inhalation. Biological monitoring of manganese exposure is problematic. It is subject to homeostasis; levels in blood (or serum/plasma) reflect only the most recent exposure and rapidly return to within normal ranges, even when there has been a temporary excursion in response to exposure. In this context, we have been developing a non-invasive technique for measurement of manganese stored in bone, using in vivo neutron activation analysis. Following preliminary feasibility studies, the technique has been enhanced by two significant infrastructure advances. A specially designed irradiation facility serves to maximize the activation of manganese with respect to the dose of ionizing radiation. Secondly, an array of eight NaI(Tl) crystals provides a detection system with very close to 4{pi} geometry. This feasibility study, using neutron activation analysis to measure manganese in the bones of the hand, takes two features into account. Firstly, there is considerable magnesium present in the bone and this produces a spectral interference with the manganese. The {sup 26}Mg(n,{gamma}){sup 27}Mg reaction produces {gamma}-rays of 0.843 MeV from the decay of {sup 27}Mg, which interfere with the 0.847 MeV {gamma}-rays from the decay of {sup 56}Mn, produced by the {sup 55}Mn(n,{gamma}){sup 56}Mn reaction. Secondly, this work provides estimates of the levels of manganese to be expected in referent subjects. A revised estimate has been made from the most recent literature to explore the potential of the technique as a suitable means of screening patients and people exposed to excessive amounts of Mn who could develop many-fold increased levels of Mn in bones as demonstrated through various animal studies. This report presents the enhancements to the neutron activation system, by which manganese can be measured, which resulted in a detection

  17. Canton hydroelectric project: feasibility study. Final report, appendices

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-01

    These appendices contain legal, environmental, regulatory, technical and economic information used in evaluating the feasibility of redeveloping the hydroelectric power generating facilities at the Upper and Lower Dams of the Farmington River at Collinsville, CT. (LCL)

  18. Computing with words to feasibility study of software projects

    Directory of Open Access Journals (Sweden)

    Marieta Peña Abreu

    2017-02-01

    Full Text Available Objective: This paper proposes a method to analyze the technical, commercial and social feasibility of software projects in environments of uncertainty. It allows working with multiple experts and multiple criteria and facilitates decision-making. Method: The proposal contains two phases, first the necessary information is collected and in second place projects are evaluated using 2-tuple linguistic representation model. The experts are selected by analyzing their curricular synthesis. The evaluation criteria are defined using the technique Focus Group and weighted in the interval (0,1 according to their importance. three domains are offered to express the preferences: numeric, interval-valued and linguistic. For aggregation extended arithmetic mean and weighted average extended are used, preventing the loss of information. A 2-tuple (feasibility, precision is obtained as a result for each project. Results: The evaluation of P1 project was a very high feasibility with -0,33 of precision. The P2 project obtained a high feasibility with 0,38 of precision and P3 project achieved a medium feasibility with -0,21 of precision. Conclusions: This method is favorable for software projects feasibility analysis with presence of multiple experts and criteria, in environments of uncertainty. It tries heterogeneous assessments without loss of information. Their results are consistent and useful for decision makers.

  19. Feasibility Pilot Study: Training Soft Skills in Virtual Worlds.

    Science.gov (United States)

    Abshier, Patricia

    2012-04-01

    In a world where funding is limited, training for healthcare professionals is turning more and more to distance learning in an effort to maintain a knowledgeable and skilled work force. In 2010, Cicatelli Associates, Inc. began exploring the feasibility of using games and virtual worlds as an alternative means to teach skills-training in a distance-learning environment. The pilot study was conducted with six individuals familiar with general counseling and communication skills used by the healthcare industry to promote behavior change. Participants reported that the venue, although challenging at first, showed great potential for use with healthcare providers, as it allowed for more interaction and activities than traditional Webinars. However, there are significant limitations that must be overcome in order for this healthcare training modality to be utilized on a large scale. These limitations included a lack of microgestures and issues regarding the technology being used. In spite of the limitations, however, the potential use of virtual worlds for the training of healthcare providers exists and should be researched further. This article discusses the need and intended benefits of virtual world training as well as the results and conclusions of the pilot study.

  20. Feasibility study of an image slicer for future space application

    Science.gov (United States)

    Calcines, A.; Ichimoto, K.

    2014-08-01

    This communication presents the feasibility study of an image slicer for future space missions, especially for the integral field unit (IFU) of the SUVIT (Solar UV-Visible-IR telescope) spectro-polarimeter on board the Japanese-led solar space mission Solar-C as a backup option. The MuSICa (Multi-Slit Image slicer based on collimator-Camera) image slicer concept, originally developed for the European Solar Telescope, has been adapted to the SUVIT requirements. The IFU will reorganizes a 2-D field of view of 10 x 10 arcsec2 into three slits of 0.18 arcsec width by 185.12 arcsec length using flat slicer mirrors of 100 μm width. The layout of MuSICa for Solar-C is telecentric and offers an optical quality limited by diffraction. The entrance for the SUVIT spectro-polarimeter is composed by the three IFU slits and one ordinal long slit to study, using high resolution spectro-polarimetry, the solar atmosphere (Photosphere and Chromosphere) within a spectral range between 520 nm (optionally 280 nm) and 1,100 nm.

  1. Home-based neurologic music therapy for arm hemiparesis following stroke: results from a pilot, feasibility randomized controlled trial.

    Science.gov (United States)

    Street, Alexander J; Magee, Wendy L; Bateman, Andrew; Parker, Michael; Odell-Miller, Helen; Fachner, Jorg

    2018-01-01

    To assess the feasibility of a randomized controlled trial to evaluate music therapy as a home-based intervention for arm hemiparesis in stroke. A pilot feasibility randomized controlled trial, with cross-over design. Randomization by statistician using computer-generated, random numbers concealed in opaque envelopes. Participants' homes across Cambridgeshire, UK. Eleven people with stroke and arm hemiparesis, 3-60 months post stroke, following discharge from community rehabilitation. Each participant engaged in therapeutic instrumental music performance in 12 individual clinical contacts, twice weekly for six weeks. Feasibility was estimated by recruitment from three community stroke teams over a 12-month period, attrition rates, completion of treatment and successful data collection. Structured interviews were conducted pre and post intervention to establish participant tolerance and preference. Action Research Arm Test and Nine-hole Peg Test data were collected at weeks 1, 6, 9, 15 and 18, pre and post intervention by a blinded assessor. A total of 11 of 14 invited participants were recruited (intervention n = 6, waitlist n = 5). In total, 10 completed treatment and data collection. It cannot be concluded whether a larger trial would be feasible due to unavailable data regarding a number of eligible patients screened. Adherence to treatment, retention and interview responses might suggest that the intervention was motivating for participants. ClinicalTrials.gov identifier NCT 02310438.

  2. Is on-demand sacral neuromodulation in patients with OAB syndrome a feasible therapy regime?

    Science.gov (United States)

    Oerlemans, Dennis J A J; van Voskuilen, Anco C; Marcelissen, Tom; Weil, Ernest H J; de Bie, Rob A; Van Kerrebroeck, Philip E V

    2011-11-01

    Sacral neuromodulation (SNM) of the lower urinary tract has proven to be safe and effective in patients with complaints of OAB syndrome who are not responding to conservative therapy. After 5 years of treatment the implanted system is still effective in 56-71% of patients. The loss of effect could be caused by adaptation of the nerve system to prolonged stimulation of the sacral nerves. We set up a pilot intervention study. After a run-in period of 2 weeks patients were randomized into two groups: one group with on-demand neuromodulation (intervention group) and one group with continuous neuromodulation (control group). Patients in the intervention group were instructed to switch their INS off by default and to switch it on again when they felt recurrent symptoms, patients in the control group were asked to use their system as normally. After 2 weeks 10 out of 16 subjects reported a comparable symptom score during on-demand use of their neuromodulation system. Patients appreciated the comfort of being self-determent in the need for therapy. Possible benefits for patients could be: more autonomy, longer battery life of the implanted INS, decreasing the chance of adaptation by the nervous system. Copyright © 2011 Wiley Periodicals, Inc.

  3. Coded excitation for diverging wave cardiac imaging: a feasibility study

    Science.gov (United States)

    Zhao, Feifei; Tong, Ling; He, Qiong; Luo, Jianwen

    2017-02-01

    Diverging wave (DW) based cardiac imaging has gained increasing interest in recent years given its capacity to achieve ultrahigh frame rate. However, the signal-to-noise ratio (SNR), contrast, and penetration depth of the resulting B-mode images are typically low as DWs spread energy over a large region. Coded excitation is known to be capable of increasing the SNR and penetration for ultrasound imaging. The aim of this study was therefore to test the feasibility of applying coded excitation in DW imaging to improve the corresponding SNR, contrast and penetration depth. To this end, two types of codes, i.e. a linear frequency modulated chirp code and a set of complementary Golay codes were tested in three different DW imaging schemes, i.e. 1 angle DW transmit without compounding, 3 and 5 angles DW transmits with coherent compounding. The performances (SNR, contrast ratio (CR), contrast-to-noise ratio (CNR), and penetration) of different imaging schemes were investigated by means of simulations and in vitro experiments. As for benchmark, corresponding DW imaging schemes with regular pulsed excitation as well as the conventional focused imaging scheme were also included. The results showed that the SNR was improved by about 10 dB using coded excitation while the penetration depth was increased by 2.5 cm and 1.8 cm using chirp code and Golay codes, respectively. The CNR and CR gains varied with the depth for different DW schemes using coded excitations. Specifically, for non-compounded DW imaging schemes, the gain in the CR was about 5 dB and 3 dB while the gain in the CNR was about 4.5 dB and 3.5 dB at larger depths using chirp code and Golay codes, respectively. For compounded imaging schemes, using coded excitation, the gain in the penetration and contrast were relatively smaller compared to non-compounded ones. Overall, these findings indicated the feasibility of coded excitation in improving the image quality of DW imaging. Preliminary in vivo cardiac images

  4. Structural Design Feasibility Study for the Global Climate Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Lewin,K.F.; Nagy, J.

    2008-12-01

    Neon, Inc. is proposing to establish a Global Change Experiment (GCE) Facility to increase our understanding of how ecological systems differ in their vulnerability to changes in climate and other relevant global change drivers, as well as provide the mechanistic basis for forecasting ecological change in the future. The experimental design was initially envisioned to consist of two complementary components; (A) a multi-factor experiment manipulating CO{sub 2}, temperature and water availability and (B) a water balance experiment. As the design analysis and cost estimates progressed, it became clear that (1) the technical difficulties of obtaining tight temperature control and maintaining elevated atmospheric carbon dioxide levels within an enclosure were greater than had been expected and (2) the envisioned study would not fit into the expected budget envelope if this was done in a partially or completely enclosed structure. After discussions between NEON management, the GCE science team, and Keith Lewin, NEON, Inc. requested Keith Lewin to expand the scope of this design study to include open-field exposure systems. In order to develop the GCE design to the point where it can be presented within a proposal for funding, a feasibility study of climate manipulation structures must be conducted to determine design approaches and rough cost estimates, and to identify advantages and disadvantages of these approaches including the associated experimental artifacts. NEON, Inc requested this design study in order to develop concepts for the climate manipulation structures to support the NEON Global Climate Experiment. This study summarizes the design concepts considered for constructing and operating the GCE Facility and their associated construction, maintenance and operations costs. Comparisons and comments about experimental artifacts, construction challenges and operational uncertainties are provided to assist in selecting the final facility design. The overall goal

  5. Feasibility study of medical isotope production at Sandia National Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Massey, C.D.; Miller, D.L.; Carson, S.D. [Sandia National Labs., Albuquerque, NM (United States). Environmental Regulatory Assessment Dept.] [and others

    1995-12-01

    In late 1994, Sandia National Laboratories in Albuquerque, New Mexico, (SNL/NM), was instructed by the Department of Energy (DOE) Isotope Production and Distribution Program (IPDP) to examine the feasibility of producing medically useful radioisotopes using the Annular Core Research Reactor (ACRR) and the Hot Cell Facility (HCF). Los Alamos National Laboratory (LANL) would be expected to supply the targets to be irradiated in the ACRR. The intent of DOE would be to provide a capability to satisfy the North American health care system demand for {sup 99}Mo, the parent of {sup 99m}Tc, in the event of an interruption in the current Canadian supply. {sup 99m}Tc is used in 70 to 80% of all nuclear medicine procedures in the US. The goal of the SNL/NM study effort is to determine the physical plant capability, infrastructure, and staffing necessary to meet the North American need for {sup 99}Mo and to identify and examine all issues with potential for environmental impact.

  6. Exercise for Adolescents with Depressive Disorders: A Feasibility Study

    Directory of Open Access Journals (Sweden)

    Richard R. Dopp

    2012-01-01

    Full Text Available Objectives. Adolescence is associated with increased depressive symptoms and decreased aerobic exercise, yet the relationship between exercise and clinical depression among adolescents requires further examination. This study assessed the feasibility of a 12-week intervention designed to increase exercise for adolescents with depressive disorders: Will a teenager with depression exercise? Methods. Participants were 13 adolescents with depression reporting low levels of aerobic exercise. They completed a 12-week intervention (15 supervised exercise sessions and 21 independent sessions. Exercise was measured through the aerobic exercise Questionnaire, actigraphy, and heart-rate monitoring. Depression was measured with the Children’s Depression Rating Scale, Revised, and Quick Inventory of Depressive Symptomatology, Self-Report. Results. All participants who started the intervention completed the protocol, attending all supervised exercise sessions. Actigraphy verified 81% adherence to the protocol’s independent sessions. Analysis of secondary outcomes showed a significant increase in exercise levels and a significant decrease in depression severity. Initially, ten participants were overweight or obese, and three were healthy weight. After 12 weeks of exercise, the number of participants in the healthy-weight category doubled. Conclusions. Adolescents suffering from depression can complete a rigorous protocol requiring structured increases in aerobic exercise. Participants showed significant increases in exercise, and significant decreases in depressive symptoms.

  7. Duet for menstrual protection: a feasibility study in Zimbabwe.

    Science.gov (United States)

    Averbach, Sarah; Sahin-Hodoglugil, Nuriye; Musara, Petina; Chipato, Tsungai; van der Straten, Ariane

    2009-06-01

    Managing menses is a challenge for women in developing countries. Duet is a cervical barrier being developed for contraception and STI prevention. We explored the hypothetical acceptability of using Duet as a menstrual cup, among Zimbabwean women. A survey and focus group discussions (FGD) were conducted with 43 women aged 18-45 years to gain information about their menstrual practices and attitudes regarding the use of Duet for menstrual protection. All 43 women reported that if Duet were available, they would "definitely" try it, and that it was "very important" that Duet is low cost and easy to clean; 86% reported that using it would make a difference in their lives. FGD findings highlighted unhygienic practices due to the lack of affordable options for menstrual management and a genuine interest in Duet, including its potential use for multiple purposes (contraception, disease prevention and menstrual protection). Accessing affordable and hygienic menstrual protection was a problem for these Zimbabwean women. Duet appeared acceptable and it would be feasible to conduct a user-acceptability study of Duet as a menstrual cup in Zimbabwe.

  8. Revised CTUIR Renewable Energy Feasibility Study Final Report

    Energy Technology Data Exchange (ETDEWEB)

    John Cox; Thomas Bailor; Theodore Repasky; Lisa Breckenridge

    2005-10-31

    This preliminary assessment of renewable energy resources on the Umatilla Indian Reservation (UIR) has been performed by CTUIR Department of Science and Engineering (DOSE). This analysis focused primarily identifying renewable resources that may be applied on or near the Umatilla Indian Reservation. In addition preliminary technical and economic feasibility of developing renewable energy resources have been prepared and initial land use planning issues identified. Renewable energies examined in the course of the investigation included solar thermal, solar photovoltaic, wind, bioethanol, bio-diesel and bio-pellet fuel. All renewable energy options studied were found to have some potential for the CTUIR. These renewable energy options are environmentally friendly, sustainable, and compliment many of the policy goals of the CTUIR. This report seeks to provide an overall review of renewable energy technologies and applications. It tries to identify existing projects near to the CTUIR and the efforts of the federal government, state government and the private sector in the renewable energy arena. It seeks to provide an understanding of the CTUIR as an energy entity. This report intends to provide general information to assist tribal leadership in making decisions related to energy, specifically renewable energy deve lopment.

  9. Feasibility study of fast neutron energy spectrometer using magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Yamagishi, Hideshi; Ara, Katsuyuki [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-09-01

    A feasibility study of a fast neutron energy spectrometer (NES) using magnetic field was performed for development of a spectrometer having a measuring range of 3 decades and a covered energy range of 8 decades. The NES that is a kind of proton recoil spectrometer consists of a proton radiator, a magnet and a screen to detect protons. The pass of each charge particle flying into the magnetic field is deflected with a certain angle depending on the velocity of the particle, and it reaches the screen of charged particle detection after passing through the magnetic field. The energy of the particle is measured from the position on the screen at which the particle collide with. In this paper, optimization of the magnet geometry and the magnetic field intensity of the NES are discussed. The NES that is designed with the optimized geometry provides the measuring range of 3 decades with an energy measuring error of less than {+-}9%. A neutron energy range of 9 decades from 0.1 (eV) to 100 (MeV) is covered by adjusting the magnetic flux density. (author)

  10. Flight Performance Feasibility Studies for the Max Launch Abort System

    Science.gov (United States)

    Tarabini, Paul V.; Gilbert, Michael G.; Beaty, James R.

    2013-01-01

    In 2007, the NASA Engineering and Safety Center (NESC) initiated the Max Launch Abort System Project to explore crew escape system concepts designed to be fully encapsulated within an aerodynamic fairing and smoothly integrated onto a launch vehicle. One objective of this design was to develop a more compact launch escape vehicle that eliminated the need for an escape tower, as was used in the Mercury and Apollo escape systems and what is planned for the Orion Multi-Purpose Crew Vehicle (MPCV). The benefits for the launch vehicle of eliminating a tower from the escape vehicle design include lower structural weights, reduced bending moments during atmospheric flight, and a decrease in induced aero-acoustic loads. This paper discusses the development of encapsulated, towerless launch escape vehicle concepts, especially as it pertains to the flight performance and systems analysis trade studies conducted to establish mission feasibility and assess system-level performance. Two different towerless escape vehicle designs are discussed in depth: one with allpropulsive control using liquid attitude control thrusters, and a second employing deployable aft swept grid fins to provide passive stability during coast. Simulation results are presented for a range of nominal and off-nominal escape conditions.

  11. Majorana One-Tonne Cryostat Cooling Conceptual Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Reid, Douglas J.; Orrell, John L.; Fast, James E.; Aguayo Navarrete, Estanislao

    2011-02-17

    This report evaluates the conceptual plans for a one-tonne (S4) cryostat cooling design. This document is based upon previous design work and experimental results used to evaluate the current MAJORANA DEMONSTRATOR (MJD) thermal design. A feasibility study of a cooling system for S4 based on the MJD thermosyphon experiment is presented. The one-tonne experiment will be a scaled up version of the MJD. There will be many cryostats for the S4 experiment. In this document a cryostat with up to 19 strings of Germanium crystals is analyzed. Aside from an extra outer ring of crystals, the geometry of both systems’ cryostats is very similar. The materials used in the fabrication of both ultra-low background experiments will be underground electroformed copper. The current MJD uses a two-phase liquid-gas cooling system to ensure constant operating temperature. This document presents a theoretical investigation of a cooling system for the S4 experiment and evaluates the heat transfer performance requirements for such a system.

  12. Towards a medical question-answering system: a feasibility study.

    Science.gov (United States)

    Jacquemart, Pierre; Zweigenbaum, Pierre

    2003-01-01

    Question-answering (QA) systems, as have been presented and evaluated in several TREC conferences, are the next generation of search engines. They combine 'traditional' Information Retrieval (IR) with Natural Language Processing (NLP) and Knowledge Engineering techniques to provide shorter, more precise answers to natural language questions. We study here the feasibility of such a system for French in the health care domain. In this purpose, we collected a corpus of student questions in oral surgery. We examined two enabling conditions: on the IR side, how to select the right keywords in a question to identify relevant material on the Web for answering this question, a prerequisite for success; and on the NLP side, whether the contents of the questions fit the conceptual model of an existing QA prototype, a favorable condition for rapid implementation. A manual Web search enabled us to devise automatable principles for building IR queries for these questions. Besides, we could design a semantic model, using UMLS Semantic Network relations, which is consistent with our prototype and covers 90% of the questions. However, the high specialization of the domain and the clinical orientation of the questions, joined with the more limited resources online in the French language, may restrain the quantity of Web material available for answering these questions.

  13. Feasibility study of tank leakage mitigation using subsurface barriers

    Energy Technology Data Exchange (ETDEWEB)

    Treat, R.L.; Peters, B.B.; Cameron, R.J.; McCormak, W.D.; Trenkler, T.; Walters, M.F. [Ensearch Environmental, Inc. (United States); Rouse, J.K.; McLaughlin, T.J. [Bovay Northwest, Inc., Richland, WA (United States); Cruse, J.M. [Westinghouse Hanford Co., Richland, WA (United States)

    1994-09-21

    The US Department of Energy (DOE) has established the Tank Waste Remediation System (TWRS) to satisfy manage and dispose of the waste currently stored in the underground storage tanks. The retrieval element of TWRS includes a work scope to develop subsurface impermeable barriers beneath SSTs. The barriers could serve as a means to contain leakage that may result from waste retrieval operations and could also support site closure activities by facilitating cleanup. Three types of subsurface barrier systems have emerged for further consideration: (1) chemical grout, (2) freeze walls, and (3) desiccant, represented in this feasibility study as a circulating air barrier. This report contains analyses of the costs and relative risks associated with combinations retrieval technologies and barrier technologies that from 14 alternatives. Eight of the alternatives include the use of subsurface barriers; the remaining six nonbarrier alternative are included in order to compare the costs, relative risks and other values of retrieval with subsurface barriers. Each alternative includes various combinations of technologies that can impact the risks associated with future contamination of the groundwater beneath the Hanford Site to varying degrees. Other potential risks associated with these alternatives, such as those related to accidents and airborne contamination resulting from retrieval and barrier emplacement operations, are not quantitatively evaluated in this report.

  14. The Mercury Project a feasibility study for Internet robots

    CERN Document Server

    Goldberg, K; Sutter, C; Wiegley, J

    2000-01-01

    Initiated at CERN in 1992, the World Wide Web provides a standard graphical interface to the Internet, and the number of users worldwide has grown exponentially in the last few years. In the Spring of 1994, we conjectured that it might be possible to offer public access to a teleoperated robot via the WWW. As a feasibility study in 1994, we built a system that allows a robot manipulator to be teleoperated via the Internet. Although the field of teleoperation dates back over 50 years, HTTP provides a low-cost and widely available interface that can make teleoperated resources accessible to a broad range of users. The Mercury Project consisted of an industrial robot arm fitted with a CCD camera and a pneumatic system. We placed a sandbox filled with buried artifacts in the robot workspace. Novice users remotely moved the camera to view desired locations and directed short bursts of compressed air into the sand to view the newly cleared regions. To our knowledge, the Mercury Project was the first Internet robot....

  15. Fort Yukon, Chalkyitsik, & Venetie Biomass Boiler Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Greg Koontz, ME William A. Wall, PhD

    2009-03-31

    The Council of Athabascan Tribal Governments (CATG) is a consortium of ten Gwich'in and Koyukon Athabascan tribes settled in 10 remote villages and are linked by the Yukon River System. The CATG mission is to maintain the Yukon Flats region as Indian Country by asserting traditional rights and taking responsibility for developing tribal technical capacity to manage the land and resources. It is the intent of CATG to explore and develop all opportunities for a renewable and self-sufficient energy program for each of the villages. CATG envisions utilization of forest resources both for construction and energy as one of the best long-term strategies for integrating the economic goals for the region as well as supporting the cultural and social issues. The intent for this feasibility project is to focus specifically on biomass utilization for heat, first, and for future electrical generation within the region, second. An initial determination has already been made regarding the importance of wood energy as a primary source of renewable energy to displace diesel fuel in the Yukon Flats region. A desktop study of other potential renewable resources was conducted in 2006.

  16. Sitewide feasibility study Eielson Air Force Base, Alaska

    Energy Technology Data Exchange (ETDEWEB)

    Last, G.V.; Lanigan, D.C.; Josephson, G.B.; Bagaasen, L.M.

    1995-09-01

    The Sitewide Feasibility Study (FS) is required under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), the National Contingency Plan (NCP), and the Federal Facility Agreement (FFA) for Eielson Air Force Base (AFB). It is based on findings presented in the Sitewide Remedial Investigation (RI) Report (USAF 1995a), and the Sitewide Baseline Risk Assessment (BLRA) Report (USAF 1995b). Under the FFA, 64 potential source areas were placed in one of six operable units, based on similar contaminant and environmental characteristics, or were included for evaluation under a Source Evaluation Report (SER). The sitewide RI was directed at contamination that was not confined to an operable unit (OU) or SER source area. The objectives of the sitewide RI were to: Provide information about site characteristics to support individual OU RI/FS efforts and the sitewide RI/FS, including site hydrogeology and determination of background soil and groundwater characteristics; identify and characterize contamination that is not confined or attributable to a specific source area through sitewide monitoring of groundwater and surface water; evaluate cumulative risks to human health and the environment from contamination on a sitewide basis; and provide a mechanism for continued cohesive sitewide monitoring.

  17. Feasibility Study of 8-Bit Microcontroller Applications for Ethernet

    Directory of Open Access Journals (Sweden)

    Lech Gulbinovič

    2011-08-01

    Full Text Available Feasibility study of 8-bit microcontroller applications for Ethernet is presented. Designed device is based on ATmega32 microcontroller and 10 Mbps Ethernet controller ENC28J60. Device is simulated as mass queuing theoretical model with ticket booking counter. Practical explorations are accomplished and characteristics are determined. Practical results are compared to theoretical ones. Program code and device packet processing speed optimization are discussed. Microcontroller packet processing speed and packet latency depend on packet size. For ICMP protocol packet processing speed varies 1.4–2.1 Mbps, latency – 0.8–8.4 ms. UDP protocol packet processing speed varies 1.3–1.8 Mbps, latency – 1.1–9.6 ms. Packet processing speed depends on compilation settings and program code compression level. Best results are reached on optimization le­vel ‑O3, then speed increased ~3% but program code size increased 68% comparing to –Os optimization level.Article in Lithuanian

  18. Exercise for Adolescents with Depressive Disorders: A Feasibility Study

    Science.gov (United States)

    Dopp, Richard R.; Mooney, Ann J.; Armitage, Roseanne; King, Cheryl

    2012-01-01

    Objectives. Adolescence is associated with increased depressive symptoms and decreased aerobic exercise, yet the relationship between exercise and clinical depression among adolescents requires further examination. This study assessed the feasibility of a 12-week intervention designed to increase exercise for adolescents with depressive disorders: Will a teenager with depression exercise? Methods. Participants were 13 adolescents with depression reporting low levels of aerobic exercise. They completed a 12-week intervention (15 supervised exercise sessions and 21 independent sessions). Exercise was measured through the aerobic exercise Questionnaire, actigraphy, and heart-rate monitoring. Depression was measured with the Children's Depression Rating Scale, Revised, and Quick Inventory of Depressive Symptomatology, Self-Report. Results. All participants who started the intervention completed the protocol, attending all supervised exercise sessions. Actigraphy verified 81% adherence to the protocol's independent sessions. Analysis of secondary outcomes showed a significant increase in exercise levels and a significant decrease in depression severity. Initially, ten participants were overweight or obese, and three were healthy weight. After 12 weeks of exercise, the number of participants in the healthy-weight category doubled. Conclusions. Adolescents suffering from depression can complete a rigorous protocol requiring structured increases in aerobic exercise. Participants showed significant increases in exercise, and significant decreases in depressive symptoms. PMID:22888415

  19. Feasibility of protein turnover studies in prototroph Saccharomyces cerevisiae strains.

    Science.gov (United States)

    Martin-Perez, Miguel; Villén, Judit

    2015-04-07

    Quantitative proteomics studies of yeast that use metabolic labeling with amino acids rely on auxotrophic mutations of one or more genes on the amino acid biosynthesis pathways. These mutations affect yeast metabolism and preclude the study of some biological processes. Overcoming this limitation, it has recently been described that proteins in a yeast prototrophic strain can also be metabolically labeled with heavy amino acids. However, the temporal profiles of label incorporation under the different phases of the prototroph's growth have not been examined. Labeling trajectories are important in the study of protein turnover and dynamics, in which label incorporation into proteins is monitored across many time points. Here we monitored protein labeling trajectories for 48 h after a pulse with heavy lysine in a yeast prototrophic strain and compared them with those of a lysine auxotrophic yeast. Labeling was successful in prototroph yeast during exponential growth phase but not in stationary phase. Furthermore, we were able to determine the half-lives of more than 1700 proteins during exponential phase of growth with high accuracy and reproducibility. We found a median half-life of 2 h in both strains, which corresponds with the cellular doubling time. Nucleolar and ribosomal proteins showed short half-lives, whereas mitochondrial proteins and other energy production enzymes presented longer half-lives. Except for some proteins involved in lysine biosynthesis, we observed a high correlation in protein half-lives between prototroph and auxotroph strains. Overall, our results demonstrate the feasibility of using prototrophs for proteomic turnover studies and provide a reliable data set of protein half-lives in exponentially growing yeast.

  20. Increasing fruits and vegetables in midlife women: a feasibility study.

    Science.gov (United States)

    Gunn, Caroline A; Weber, Janet L; Coad, Jane; Kruger, Marlena C

    2013-07-01

    The positive link between bone health and fruit/vegetable consumption has been attributed to the lower renal acid load of a diet high in alkaline-forming fruit/vegetables. Other important dietary determinants of bone health include micronutrients and bioactives found in fruit/vegetables. We hypothesized that increased intake of fruit/vegetables to 9 or more servings a day would lower net endogenous acid production (NEAP) significantly (~20 mEq/d) and increase urine pH (0.5 pH units). This 8-week feasibility study investigated if 21 midlife women (age, 40-65 years) currently consuming 5 or less servings a day of fruit/vegetables could increase their intake to 9 or more servings a day to substantially lower NEAP and include specific vegetables daily. Three-day diet diaries were completed at baseline and the end of the study and assessed for NEAP (estimated) and number of servings from all food groups. Urine pH dipsticks were provided for the participants to assess and record their fasting urine pH daily (second void). Seventy-six percent of women achieved the study aim, which was to increase to 9 or more servings of fruit/vegetables for at least 5 d/wk. There was a reduction in the number of bread/cereal servings. Net endogenous acid production (estimated) was reduced significantly, with a mean urine pH increase of 0.68 pH units (95% confidence interval, 0.46-1.14); however, daily urine pH measures showed high variability. This study demonstrated that a group of midlife women can change their diet for 8 weeks by significantly increasing fruit/vegetable servings and include specific "bone friendly" vegetables daily, resulting in a significant decrease in estimated dietary NEAP and an increase in urine pH. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Feasibility study on the development of advanced LWR fuel technology

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Youn Ho; Sohn, D. S.; Jeong, Y. H.; Song, K. W.; Song, K. N.; Chun, T. H.; Bang, J. G.; Bae, K. K.; Kim, D. H. and others

    1997-07-01

    Worldwide R and D trends related to core technology of LWR fuels and status of patents have been surveyed for the feasibility study. In addition, various fuel cycle schemes have been studied to establish the target performance parameters. For the development of cladding material, establishment of long-term research plan for alloy development and optimization of melting process and manufacturing technology were conducted. A work which could characterize the effect of sintering additives on the microstructure of UO{sub 2} pellet has been experimentally undertaken, and major sintering variables and their ranges have been found in the sintering process of UO{sub 2}-Gd{sub 2}O{sub 3} burnable absorber pellet. The analysis of state of the art technology related to flow mixing device for spacer grid and debris filtering device for bottom nozzle and the investigation of the physical phenomena related to CHF enhancement and the establishment of the data base for thermal-hydraulic performance tests has been done in this study. In addition, survey on the documents of the up-to-date PWR fuel assemblies developed by foreign vendors have been carried out to understand their R and D trends and establish the direction of R and D for these structural components. And, to set the performance target of the new fuel, to be developed, fuel burnup and economy under the extended fuel cycle length scheme were estimated. A preliminary study on the failure mechanism of CANDU fuel, key technology and advanced coating has been performed. (author). 190 refs., 31 tabs., 129 figs.

  2. Neuropsychological functioning in adolescents with anorexia nervosa before and after cognitive remediation therapy: a feasibility trial.

    Science.gov (United States)

    Dahlgren, Camilla Lindvall; Lask, Bryan; Landrø, Nils Inge; Rø, Øyvind

    2013-09-01

    To investigate neuropsychological functioning in adolescents with anorexia nervosa (AN) before and after receiving cognitive remediation therapy (CRT). Twenty young females with AN participated in an individually-delivered CRT treatment program. Neuropsychological and psychiatric assessments were administered before and after treatment. Weight, depression, anxiety, duration of illness, and level of eating disorder psychopathology were considered as covariates in statistical analyses. Significant changes in weight, depression, visio-spatial memory, perceptual disembedding abilities, and verbal fluency were observed. Changes in weight had a significant effect on improvements in visuo-spatial memory and verbal fluency. Results also revealed a significant effect of depressive symptoms on perceptual disembedding abilities. The results suggest improvements on a number of neuropsychological functions during the course of CRT. Future studies should explore the use of additional assessment instruments, and include control groups to assess the effectiveness of the intervention. Copyright © 2013 Wiley Periodicals, Inc.

  3. Stereotactic body radiation therapy for liver metastases from colorectal cancer: analysis of safety, feasibility, and early outcomes

    Directory of Open Access Journals (Sweden)

    Marie-Adele Sorel Kress

    2012-02-01

    Full Text Available Introduction: Colorectal cancer (CRC is the 3rd leading cause of cancer-related death in the U.S. Many patients with CRC develop hepatic metastases as the sole site of metastases. Historical treatment options were limited to resection or conventional radiation therapy. Stereotactic body radiation therapy (SBRT has emerged as a rational treatment approach. This study reviews our experience with SBRT for patients with liver metastases from CRC.Material and Methods: Fourteen histologically confirmed hepatic CRC metastases in 11 consecutive patients were identified between November, 2004 and June, 2009 at Georgetown University. All patients underwent CT-based treatment planning; a few also had MRI or PET/CT. All patients had fiducial markers placed under CT guidance and were treated using the CyberKnife system. Treatment response and toxicities were examined; survival and local control were evaluated.Results: Most patients were treated to a single hepatic lesion (n=8, with a few treated to 2 lesions (n=3. Median treatment volume was 99.7 cm3, and lesions were treated to a median BED10 of 49.7 Gy (range: 28 – 100.8 Gy. Median follow-up was 21 months; median survival was 16.1 months, with 2-year actuarial survival of 25.7%. One-year local control was 72%. Among patients with post-treatment imaging, 8 had stable disease (80% and 2 had progressive disease (20% at first follow-up. The most common grade 1-2 acute toxicities included nausea and alterations in liver function tests; there was one grade 3 toxicity (elevated bilirubin, and no grade 4-5 toxicities.Discussion: SBRT is safe and feasible for the treatment of limited hepatic metastases from CRC. Our results compare favorably with outcomes from previous studies of SBRT. Further studies are needed to better define patient eligibility, study the role of combined modality treatment, optimize treatment parameters, and characterize quality of life after treatment.

  4. The Distinctive Features of a Feasibility Study: Objectives and Guiding Questions.

    Science.gov (United States)

    Orsmond, Gael I; Cohn, Ellen S

    2015-07-01

    In this article, we highlight the distinctive features of a feasibility study, identify the main objectives and guiding questions of a feasibility study, and illustrate the use of these objectives. We synthesized the research methods literature related to feasibility studies to identify five overarching objectives of feasibility studies that focus on social and behavioral interventions. Feasibility studies are designed to answer the overarching question: Can it work? The main objectives of feasibility include the assessment of recruitment capability and resulting sample characteristics, data collection procedures and outcome measures, acceptability of the intervention and study procedures, resources and ability to manage and implement the study and intervention, and preliminary evaluation of participant responses to the intervention. For each objective, we identified follow-up questions designed to assist the researchers to understand barriers to the ultimate success of the research.

  5. Stroke experiences in weblogs: a feasibility study of sex differences.

    Science.gov (United States)

    Koh, Sukjin; Gordon, Andrew S; Wienberg, Christopher; Sood, Sara O; Morley, Stephanie; Burke, Deborah M

    2014-03-19

    Research on cerebral stroke symptoms using hospital records has reported that women experience more nontraditional symptoms of stroke (eg, mental status change, pain) than men do. This is an important issue because nontraditional symptoms may delay the decision to get medical assistance and increase the difficulty of correct diagnosis. In the present study, we investigate sex differences in the stroke experience as described in stories on weblogs. The goal of this study was to investigate the feasibility of using the Internet as a source of data for basic research on stroke experiences. Stroke experiences described in blogs were identified by using StoryUpgrade, a program that searches blog posts using a fictional prototype story. In this study, the prototype story was a description of a stroke experience. Retrieved stories coded by the researchers as relevant were used to update the search query and retrieve more stories using relevance feedback. Stories were coded for first- or third-person narrator, traditional and nontraditional patient symptoms, type of stroke, patient sex and age, delay before seeking medical assistance, and delay at hospital and in treatment. There were 191 relevant stroke stories of which 174 stories reported symptoms (52.3% female and 47.7% male patients). There were no sex differences for each traditional or nontraditional stroke symptom by chi-square analysis (all Ps>.05). Type of narrator, however, affected report of traditional and nontraditional symptoms. Female first-person narrators (ie, the patient) were more likely to report mental status change (56.3%, 27/48) than male first-person narrators (36.4%, 16/44), a marginally significant effect by logistic regression (P=.056), whereas reports of third-person narrators did not differ for women (27.9%, 12/43) and men (28.2%, 11/39) patients. There were more reports of at least 1 nontraditional symptom in the 92 first-person reports (44.6%, 41/92) than in the 82 third-person reports (25

  6. Pueblo of Jemez Geothermal Feasibility Study Fianl Report

    Energy Technology Data Exchange (ETDEWEB)

    S.A. Kelley; N. Rogers; S. Sandberg; J. Witcher; J. Whittier

    2005-03-31

    This project assessed the feasibility of developing geothermal energy on the Pueblo of Jemez, with particular attention to the Red Rocks area. Geologic mapping of the Red Rocks area was done at a scale of 1:6000 and geophysical surveys identified a potential drilling target at a depth of 420 feet. The most feasible business identified to use geothermal energy on the reservation was a greenhouse growing culinary and medicinal herbs. Space heating and a spa were identified as two other likely uses of geothermal energy at Jemez Pueblo. Further geophysical surveys are needed to identify the depth to the Madera Limestone, the most likely host for a major geothermal reservoir.

  7. Feasibility of the Dutch ICF Activity Inventory: a pilot study

    Directory of Open Access Journals (Sweden)

    van Nispen Ruth MA

    2010-11-01

    Full Text Available Abstract Background Demographic ageing will lead to increasing pressure on visual rehabilitation services, which need to be efficiently organised in the near future. The Dutch ICF Activity Inventory (D-AI was developed to assess the rehabilitation needs of visually impaired persons. This pilot study tests the feasibility of the D-AI using a computer-assisted telephone interview. Methods In addition to the regular intake, the first version of the D-AI was assessed in 20 patients. Subsequently, patients and intake assessors were asked to fill in an evaluation form. Based on these evaluations, a new version of the D-AI was developed. Results Mean administration time of the D-AI was 88.8 (± 41.0 minutes. Overall, patients and assessors were positive about the D-AI assessment. However, professionals and 60% of the patients found the administration time to be too long. All included items were considered relevant and only minor adjustments were recommended. Conclusion The systematic character of the revised D-AI will prevent topics from being overlooked and indicate which needs have the highest priority from a patient-centred perspective. Moreover, ongoing assessment of the D-AI will enhance evaluation of the rehabilitation process. To decrease administration time, in the revised D-AI only the top priority goals will be fully assessed. Using the D-AI, a rehabilitation plan based on individual needs can be developed for each patient. Moreover, it enables better evaluation of the effects of rehabilitation. A larger validation study is planned.

  8. Feasibility study of fluxless brazing cemented carbides to steel

    Science.gov (United States)

    Tillmann, W.; Sievers, N.

    2017-03-01

    One of the most important brazing processes is the joints between cemented carbides and steel for the tool industry such as in rotary drill hammers or saw blades. Even though this technique has already been used for several decades, defects in the joint can still occur and lead to quality loss. Mostly, the joining process is facilitated by induction heating and the use of a flux to enhance the wetting of the filler alloy on the surface of the steel and cemented carbide in an ambient atmosphere. However, although the use of flux enables successful joining, it also generates voids within the joint, which reduces the strength of the connection while the chemicals within the flux are toxic and polluting. In this feasibility study, a fluxless brazing process is used to examine the joint between cemented carbides and steel for the first time. For this, ultrasound is applied during induction heating to enable the wetting between the liquid filler metal and the surfaces of the cemented carbide and steel. The ultrasound generates cavitations within the liquid filler metal, which remove the oxides from the surface. Several filler metals such as a silver based alloy Ag449, pure Zn, and an AlSi-alloy were used to reduce the brazing temperature and to lower the thermal residual stresses within the joint. As a result, every filler metal successfully wetted both materials and led to a dense connection. The ultrasound has to be applied carefully to prevent a damage of the cemented carbide. In this regard, it was observed that single grains of the cemented carbide broke out and remained in the joint. This positive result of brazing cemented carbides to steel without a flux but using ultrasound, allows future studies to focus on the shear strength of these joints as well as the behavior of the thermally induced residual stresses.

  9. Optical monitoring of spinal cord hemodynamics, a feasibility study

    Science.gov (United States)

    Shadgan, Babak; Kwon, Brian K.; Streijger, Femke; Manouchehri, Neda; So, Kitty; Shortt, Katelyn; Cripton, Peter A.; Macnab, Andrew

    2017-02-01

    Background: After an acute traumatic spinal cord injury (SCI), the spinal cord is subjected to ischemia, hypoxia, and increased hydrostatic pressure which exacerbate further secondary damage and neuronal deficit. The purpose of this pilot study was to explore the use of near infrared spectroscopy (NIRS) for non-invasive and real-time monitoring of these changes within the injured spinal cord in an animal model. NIRS is a non-invasive optical technique that utilizes light in the near infrared spectrum to monitor changes in the concentration of tissue chromophores from which alterations in tissues oxygenation and perfusion can be inferred in real time. Methods: A custom-made miniaturized NIRS sensor was developed to monitor spinal cord hemodynamics and oxygenation noninvasively and in real time simultaneously with invasive, intraparenchymal monitoring in a pig model of SCI. The spinal cord around the T10 injury site was instrumented with intraparenchymal probes inserted directly into the spinal cord to measure oxygen pressure, blood flow, and hydrostatic pressure, and the same region of the spinal cord was monitored with the custom-designed extradural NIRS probe. We investigated how well the extradural NIRS probe detected intraparenchymal changes adjacent to the injury site after alterations in systemic blood pressure, global hypoxia, and traumatic injury generated by a weight-drop contusion. Results: The NIRS sensor successfully identified periods of systemic hypoxia, re-ventilation and changes in spinal cord perfusion and oxygenation during alterations of mean arterial pressure and following spinal cord injury. Conclusion: This pilot study indicates that extradural NIRS monitoring of the spinal cord is feasible as a non-invasive optical method to identify changes in spinal cord hemodynamics and oxygenation in real time. Further development of this technique would allow clinicians to monitor real-time physiologic changes within the injured spinal cord during the

  10. Metronomic photodynamic therapy (mPDT): concepts and technical feasibility in brain tumor

    Science.gov (United States)

    Wilson, Brian C.; Bisland, Stuart K.; Bogaards, Arjen; Lin, Annie; Moriyama, Eduardo H.; Zhang, Kai; Lilge, Lothar D.

    2003-06-01

    The concept of metronomic photodynamic therapy (mPDT) is presented, in which both the photosensitizer and light are delivered continuously at low rates over extended periods in order to increase selective tumor cell kill through apoptosis. The focus of the present work is on mPDT treatment of malignant brain tumors, in which selectivity between damage to tumor cells versus normal brain tissue is critical. Previous studies have shown that low-dose PDT using aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) can induce apoptosis in tumor cells without causing necrosis in either tumor or normal brain tissue or apoptosis in the latter. In order to produce enough tumor cell kill to be an effective therapy, multiple PDT treatments, such as hyperfractionation or metronomic delivery, are likely requried, based on the levels of apoptosis achieved and model calculations of tumor growth rates. mPDT poses two substantial technical challenges: extended delivery of ALA and implantation of interstitial devices for extended light delivery while allowing free movement. In rat models ALA administration via the drinking water has been accomplished at significant doses for up to 10 days, and ex vivo spectrofluorimetry of tumore, normal brain and other tissues post mortem demonstrates a 3-4 increase in the tumor-to-brain concentration of PpIX, without toxicity. Prototype light sources and delivery devices are also shown to be practical, either using a laser diode or light emitting diode (LED) coupled to an implanted optical fiber in the case of the rat model or a directly-implanted LED in rabbits. The combined delivery of both drug and light over an extended period, with survival of the animals, is demonstrated. Preliminary evidence of selective apoptosis of tumor under these conditions is presented.

  11. Feasibility and Association of Neurohumoral Blocker Up-titration After Cardiac Resynchronization Therapy.

    Science.gov (United States)

    Martens, Pieter; Verbrugge, Frederik H; Nijst, Petra; Bertrand, Philippe B; Dupont, Matthias; Tang, Wilson H; Mullens, Wilfried

    2017-08-01

    Cardiac resynchronization therapy (CRT) improves mortality and morbidity on top of optimal medical therapy in heart failure with reduced ejection fraction (HFrEF). This study aimed to elucidate the association between neurohumoral blocker up-titration after CRT implantation and clinical outcomes. Doses of angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers (ARBs), and beta-blockers were retrospectively evaluated in 650 consecutive CRT patients implanted from October 2008 to August 2015 and followed in a tertiary multidisciplinary CRT clinic. All 650 CRT patients were on a maximal tolerable dose of ACE-I/ARB and beta-blocker at the time of CRT implantation. However, further up-titration was successful in 45.4% for ACE-I/ARB and in 56.8% for beta-blocker after CRT-implantation. During a mean follow-up of 37 ± 22 months, a total of 139 events occurred for the combined end point of heart failure admission and all-cause mortality. Successful, versus unsuccessful, up-titration was associated with adjusted hazard ratios of 0.537 (95% confidence interval 0.316-0.913; P = .022) for ACE-I/ARB and 0.633 (0.406-0.988; P = .044) for beta-blocker on the combined end point heart failure admission and all-cause mortality. Patients in the up-titration group exhibited a similar risk for death or heart failure admission as patients treated with the maximal dose (ACE-I/ARB: P = .133; beta-blockers: P = .709). After CRT, a majority of patients are capable of tolerating higher dosages of neurohumoral blockers. Up-titration of neurohumoral blockers after CRT implantation is associated with improved clinical outcomes, similarly to patients treated with the guideline-recommended target dose at the time of CRT implantation. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Comprehensive Renewable Energy Feasibility Study for Sealaska Corporation

    Energy Technology Data Exchange (ETDEWEB)

    Robert Lynette; John Wade: Larry Coupe

    2006-06-30

    The purposes of this project were: (1) to conduct a comprehensive feasibility study to determine the potential sustainability of wind and/or small hydroelectric power plants on Southeast Alaska native village lands, and (2) to provide the villages with an understanding of the requirements, costs, and benefits of developing and operating wind or small hydroelectric power plants. The program was sponsored by the Tribal Energy program, Office of Energy Efficiency and Renewable Energy, US Department of Energy. The Contractor was Sealaska Corporation, the Regional Native Corporation for Southeast Alaska that includes 12 village/urban corporations. Most villages are isolated from any central electric transmission and use diesel-electric systems for power generation, making them prime candidates for deploying renewable energy sources. Wind Energy - A database was assembled for all of the candidate sites in SE Alaska, including location, demographics, electricity supply and demand, existing and planned transmission interties with central generation, topographical maps, macro wind data, and contact personnel. Field trips were conducted at the five candidate villages that were deemed most likely to have viable wind resources. Meetings were held with local village and utility leaders and the requirements, costs, and benefits of having local renewable energy facilities were discussed. Two sites were selected for anemometry based on their needs and the probability of having viable wind resources – Yakutat and Hoonah. Anemometry was installed at both sites and at least one year of wind resource data was collected from the sites. This data was compared to long-term data from the closest weather stations. Reports were prepared by meteorologist John Wade that contains the details of the measured wind resources and energy production projections. Preliminary financial analysis of hypothetical wind power stations were prepared to gauge the economic viability of installing such

  13. Feasibility of the Helping Alliance Questionnaire – II (HAq- II) in psychiatric patients receiving music therapy

    DEFF Research Database (Denmark)

    Hannibal, Niels Jørgensen; Licht, Rasmus Wentzer; Rodrigo, Maria

    2017-01-01

    Background: High adherence to music therapy in psychiatry may indicate the forming of a helping alliance. However, no prior attempts have been made to measure the alliance during music therapy. Objective: To evaluate the applicability of the Helping Alliance Questionnaire – II (HAq-II) in patients...... receiving music therapy. Internal consistency and associations between patient variables and HAq-II scores were also examined. Methods: Between October 2013 and April 2014, psychiatric patients receiving music therapy were invited to fill out the HAq-II. Clinical data were collected from the patient records...... predictors of interest w ere found. Conclusions: The HAq-II was applicable to the majority of a group of psychiatric patients receiving music therapy. An acceptable internal consistency of the questionnaire was found. Relatively high HAq-II scores suggest a high degree of therapeutic alliance...

  14. Feasibility Study for Renewable Energy Development on Tribal Lands

    Energy Technology Data Exchange (ETDEWEB)

    John Hendrix, Project Director; Charles Weir, Project Manager; Dr. John Plodinec, Technology Advisor; Dr. Steve Murray, Economic Advisor

    2005-07-21

    Project Objective: The Mississippi Band of Choctaw Indians (MBCI) conducted a study of the feasibility of siting a renewable energy biomass-based installation on tribal lands. The purpose of the study was to determine whether such an installation can be economically sustainable, as well as consistent with the cultural, social, and economic goals of the Tribe. Scope: To achieve the goal of the feasibility study, the following tasks were carried out: (1) Resource availability assessment--The objective of this assessment was to determine the availability of both poultry litter and wood residues for use in the proposed facility. (2) Power utilization assessment--The objective of this assessment was to determine the potential market size for power produced, the existing infrastructure for delivering power to that market, and the costs and economic returns for doing so. (3) Technology review--The objective of this review was to identify one, or more, technical options for detailed economic and technical assessment. The study considered a range of feedstock and product mixtures of poultry litter; wood residues as feedstock; and electrical power and other ancillary products as outputs. Distributed power sources was also examined. Technologies ranging from gasification to systems that produce both power and value-added chemicals were considered. Technologies selected for detailed review were those that can be sized to process the amount of available feed (poultry litter, or poultry litter and wood residues), and that also appear to make economic sense in terms of the value of their inputs. The technology review leaned heavily on the experience from similar prior DOE projects, particularly those conducted by the National Renewable Energy Laboratory (NREL). NREL was involved in a consultative role, so that the project team could leverage their experience. (4) Systems Design(s)--Based on the technology review, a pre-conceptual design for an installation was developed. This

  15. A gEUD-based inverse planning technique for HDR prostate brachytherapy: feasibility study.

    Science.gov (United States)

    Giantsoudi, D; Baltas, D; Karabis, A; Mavroidis, P; Zamboglou, N; Tselis, N; Shi, C; Papanikolaou, N

    2013-04-01

    The purpose of this work was to study the feasibility of a new inverse planning technique based on the generalized equivalent uniform dose for image-guided high dose rate (HDR) prostate cancer brachytherapy in comparison to conventional dose-volume based optimization. The quality of 12 clinical HDR brachytherapy implants for prostate utilizing HIPO (Hybrid Inverse Planning Optimization) is compared with alternative plans, which were produced through inverse planning using the generalized equivalent uniform dose (gEUD). All the common dose-volume indices for the prostate and the organs at risk were considered together with radiobiological measures. The clinical effectiveness of the different dose distributions was investigated by comparing dose volume histogram and gEUD evaluators. Our results demonstrate the feasibility of gEUD-based inverse planning in HDR brachytherapy implants for prostate. A statistically significant decrease in D10 or/and final gEUD values for the organs at risk (urethra, bladder, and rectum) was found while improving dose homogeneity or dose conformity of the target volume. Following the promising results of gEUD-based optimization in intensity modulated radiation therapy treatment optimization, as reported in the literature, the implementation of a similar model in HDR brachytherapy treatment plan optimization is suggested by this study. The potential of improved sparing of organs at risk was shown for various gEUD-based optimization parameter protocols, which indicates the ability of this method to adapt to the user's preferences.

  16. A gEUD-based inverse planning technique for HDR prostate brachytherapy: Feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Giantsoudi, D. [Department of Radiological Sciences, University of Texas Health Sciences Center, San Antonio, Texas 78229 (United States); Department of Radiation Oncology, Francis H. Burr Proton Therapy Center, Boston, Massachusetts 02114 (United States); Baltas, D. [Department of Medical Physics and Engineering, Strahlenklinik, Klinikum Offenbach GmbH, 63069 Offenbach (Germany); Nuclear and Particle Physics Section, Physics Department, University of Athens, 15701 Athens (Greece); Karabis, A. [Pi-Medical Ltd., Athens 10676 (Greece); Mavroidis, P. [Department of Radiological Sciences, University of Texas Health Sciences Center, San Antonio, Texas 78299 and Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, 17176 (Sweden); Zamboglou, N.; Tselis, N. [Strahlenklinik, Klinikum Offenbach GmbH, 63069 Offenbach (Germany); Shi, C. [St. Vincent' s Medical Center, 2800 Main Street, Bridgeport, Connecticut 06606 (United States); Papanikolaou, N. [Department of Radiological Sciences, University of Texas Health Sciences Center, San Antonio, Texas 78299 (United States)

    2013-04-15

    Purpose: The purpose of this work was to study the feasibility of a new inverse planning technique based on the generalized equivalent uniform dose for image-guided high dose rate (HDR) prostate cancer brachytherapy in comparison to conventional dose-volume based optimization. Methods: The quality of 12 clinical HDR brachytherapy implants for prostate utilizing HIPO (Hybrid Inverse Planning Optimization) is compared with alternative plans, which were produced through inverse planning using the generalized equivalent uniform dose (gEUD). All the common dose-volume indices for the prostate and the organs at risk were considered together with radiobiological measures. The clinical effectiveness of the different dose distributions was investigated by comparing dose volume histogram and gEUD evaluators. Results: Our results demonstrate the feasibility of gEUD-based inverse planning in HDR brachytherapy implants for prostate. A statistically significant decrease in D{sub 10} or/and final gEUD values for the organs at risk (urethra, bladder, and rectum) was found while improving dose homogeneity or dose conformity of the target volume. Conclusions: Following the promising results of gEUD-based optimization in intensity modulated radiation therapy treatment optimization, as reported in the literature, the implementation of a similar model in HDR brachytherapy treatment plan optimization is suggested by this study. The potential of improved sparing of organs at risk was shown for various gEUD-based optimization parameter protocols, which indicates the ability of this method to adapt to the user's preferences.

  17. pilot studies to test the feasibility of a birth cohort study investigating ...

    African Journals Online (AJOL)

    1991-04-20

    Apr 20, 1991 ... Birth to Ten' is a birth cohort study currently being conducted in the Johannesburg-Soweto area. This paper describes the various pilot studies that were undertaken to investigate the feasibility of a cohort study in an urban area. These studies were designed to determine the monthly birth rate, the timing,.

  18. 'Birth to Ten' - pilot studies to test the feasibility of a birth cohort study ...

    African Journals Online (AJOL)

    Birth to Ten' is a birth cohort study currently being conducted in the Johannesburg-Soweto area. This paper describes the various pilot studies that were undertaken to investigate the feasibility of a cohort study in an urban area. These studies were designed to determine the monthly birth rate, the timing, frequency and ...

  19. Dosimetric feasibility study for an extracorporeal BNCT application on liver metastases at the TRIGA Mainz

    Energy Technology Data Exchange (ETDEWEB)

    Blaickner, M., E-mail: matthias.blaickner@ait.ac.at [Health and Environment Department-Molecular Medicine, AIT Austrian Institute of Technology GmbH, Muthgasse 11, A-1190 Vienna (Austria); Kratz, J.V. [Institut fuer Kernchemie, Johannes Gutenberg-Universitaet Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany); Minouchehr, S.; Otto, G. [Transplantationschirurgie, Universitaetsklinikum Mainz, Langenbeckstr.1, D-55131 Mainz (Germany); Schmidberger, H. [Klinik und Poliklinik fuer Radioonkologie und Strahlentherapie, Universitaetsklinikum Mainz, Langenbeckstr.1, D-55131 Mainz (Germany); Schuetz, C.; Vogtlaender, L. [Institut fuer Kernchemie, Johannes Gutenberg-Universitaet Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany); Wortmann, B. [Evonik Energy Services GmbH Essen, Ruettenscheider Str. 1-3, D-45128 Essen (Germany); Hampel, G. [Institut fuer Kernchemie, Johannes Gutenberg-Universitaet Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany)

    2012-01-15

    This study investigates the dosimetric feasibility of Boron Neutron Capture Therapy (BNCT) of explanted livers in the thermal column of the research reactor in Mainz. The Monte Carlo code MCNP5 is used to calculate the biologically weighted dose for different ratios of the {sup 10}B-concentration in tumour to normal liver tissue. The simulation results show that dosimetric goals are only partially met. To guarantee effective BNCT treatment the organ has to be better shielded from all gamma radiation. - Highlights: Black-Right-Pointing-Pointer Monte Carlo simulations demonstrate the potential for BNCT treatment at TRIGA Mainz. Black-Right-Pointing-Pointer Simulation shows the necessity of gamma shielding for the organ from all sides. Black-Right-Pointing-Pointer Secondary photons induced within the graphite contribute considerably to gamma dose.

  20. Fernald Environmental Management Project remedial investigation and feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Layton, J.C.

    1993-04-15

    Environmental restoration involves the cleanup and restoration of US Department of Energy (DOE) sites and facilities contaminated with hazardous substances during past production or disposal activities. An important element of the environmental restoration process is the remedial investigation and feasibility study (RI/FS), which is designed to determine the extent of contamination and to identify alternatives for cleanup. The Office of the Assistant Secretary for Environmental Restoration and Waste Management is responsible for policy direction and oversight of DOE`s environmental restoration program. The objective of the audit was to determine whether DOE and its contractors had developed effective management control systems to ensure that maximum benefits were obtained from the funds spent on the RI/FS at the Fernald Environmental Management Project. Although DOE had improved the Fernald RI/FS project over the previous 18 months, the project at Fernald was not planned and controlled cost effectively. This condition occurred because (1) DOE and its contractors lacked experience in the RI/FS process, (2) DOE and its contractors had not communicated effectively with one another and outside regulators, and (3) DOE had not placed enough emphasis on management control systems. As a result, after about 6 years and the expenditure of over $100 million on the RI/FS project at Fernald, DOE and the Environmental Protection Agency (EPA) had made no decisions as to future land use, cleanup methods, disposal sites, or the level of environmental protection needed for the site. For each year that the completion of the RI/FS and cleanup is unnecessarily delayed, DOE will be required to spend about $149 million to support site infrastructure costs. Finally, DOE was planning for the possible construction of waste storage buildings, estimated to cost $2.6 billion, when the need for the buildings had not been validated .

  1. Fernald Environmental Management Project remedial investigation and feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Layton, J.C.

    1993-04-15

    Environmental restoration involves the cleanup and restoration of US Department of Energy (DOE) sites and facilities contaminated with hazardous substances during past production or disposal activities. An important element of the environmental restoration process is the remedial investigation and feasibility study (RI/FS), which is designed to determine the extent of contamination and to identify alternatives for cleanup. The Office of the Assistant Secretary for Environmental Restoration and Waste Management is responsible for policy direction and oversight of DOE's environmental restoration program. The objective of the audit was to determine whether DOE and its contractors had developed effective management control systems to ensure that maximum benefits were obtained from the funds spent on the RI/FS at the Fernald Environmental Management Project. Although DOE had improved the Fernald RI/FS project over the previous 18 months, the project at Fernald was not planned and controlled cost effectively. This condition occurred because (1) DOE and its contractors lacked experience in the RI/FS process, (2) DOE and its contractors had not communicated effectively with one another and outside regulators, and (3) DOE had not placed enough emphasis on management control systems. As a result, after about 6 years and the expenditure of over $100 million on the RI/FS project at Fernald, DOE and the Environmental Protection Agency (EPA) had made no decisions as to future land use, cleanup methods, disposal sites, or the level of environmental protection needed for the site. For each year that the completion of the RI/FS and cleanup is unnecessarily delayed, DOE will be required to spend about $149 million to support site infrastructure costs. Finally, DOE was planning for the possible construction of waste storage buildings, estimated to cost $2.6 billion, when the need for the buildings had not been validated .

  2. Testicular ultrasensitive Doppler preliminary experience: a feasibility study.

    Science.gov (United States)

    Rocher, Laurence; Gennisson, Jean-Luc; Ferlicot, Sophie; Criton, Aline; Albiges, Laurence; Izard, Vincent; Bellin, Marie France; Correas, Jean-Michel

    2018-03-01

    Background Ultrasensitive Doppler is a novel non-invasive ultrasound (US) Doppler technique that improves sensitivity and resolution for the detection of slow flow. Purpose To investigate the feasibility of ultrasensitive Doppler (USD) for testicular disease diagnosis, using both qualitative and quantitative results. Material and Methods This prospective study was conducted in 160 successive men referred for scrotal US including B-mode and conventional Color-Doppler. A new USD sequence and algorithm dedicated to academic research were implemented into the US system. The quality criterion for a successful examination was the detection of well delineated intratesticular vessels. Qualitative USD results were described in terms of tumor vascular architecture and flow intensity for different pathologies for 41 patients. The testicular vascularization (TV), defined as a vessel's surface ratio, was quantified using customized MATLAB® software and compared in azoospermic and normal patients. Results USD was acquired successfully in 153/160 patients (95.6%). The tumor vascular architecture differed depending on the nature of the tumors. Leydig cell tumors exhibited mostly circumferential vascularization, while germ cell tumors exhibited straight vessels through the tumors, or anarchic vascular maps. USD improved the diagnostic performance of testicular Doppler US in a case of incomplete spermatic cord torsion and acute epididymitis. The reproducibility of TV measurements established an interclass correlation of 0.801. Non-Klinefelter syndrome non-obstructive azoospermia patients exhibited a lower TV compared to normal patients, to Klinefelter syndrome, and to obstructive azoospermia patients ( P < 0.002, P < 0.005, and P < 0.05, respectively). Conclusion Testicular USD can become a promising technique for improving US diagnosis of tumors, acute scrotum, and for determining infertility status.

  3. Automated estimation of hip prosthesis migration: a feasibility study

    Science.gov (United States)

    Vandemeulebroucke, Jef; Deklerck, Rudi; Temmermans, Frederik; Van Gompel, Gert; Buls, Nico; Scheerlinck, Thierry; de Mey, Johan

    2013-09-01

    A common complication associated with hip arthoplasty is prosthesis migration, and for most cemented components a migration greater than 0.85 mm within the first six months after surgery, are an indicator for prosthesis failure. Currently, prosthesis migration is evaluated using X-ray images, which can only reliably estimate migrations larger than 5 mm. We propose an automated method for estimating prosthesis migration more accurately, using CT images and image registration techniques. We report on the results obtained using an experimental set-up, in which a metal prosthesis can be translated and rotated with respect to a cadaver femur, over distances and angles applied using a combination of positioning stages. Images are first preprocessed to reduce artefacts. Bone and prosthesis are extracted using consecutive thresholding and morphological operations. Two registrations are performed, one aligning the bones and the other aligning the prostheses. The migration is estimated as the difference between the found transformations. We use a robust, multi-resolution, stochastic optimization approach, and compare the mean squared intensity differences (MS) to mutual information (MI). 30 high-resolution helical CT scans were acquired for prosthesis translations ranging from 0.05 mm to 4 mm, and rotations ranging from 0.3° to 3° . For the translations, the mean 3D registration error was found to be 0.22 mm for MS, and 0.15 mm for MI. For the rotations, the standard deviation of the estimation error was 0.18° for MS, and 0.08° for MI. The results show that the proposed approach is feasible and that clinically acceptable accuracies can be obtained. Clinical validation studies on patient images will now be undertaken.

  4. CVD diamond Brewster window: feasibility study by FEM analyses

    Directory of Open Access Journals (Sweden)

    Vaccaro A.

    2012-09-01

    Full Text Available Chemical vapor deposition (CVD diamond windows are a crucial component in heating and current drive (H&CD applications. In order to minimize the amount of reflected power from the diamond disc, its thickness must match the desired beam wavelength, thus proper targeting of the plasma requires movable beam reflectors. This is the case, for instance, of the ITER electron cyclotron H&CD system. However, looking at DEMO, the higher heat loads and neutron fluxes could make the use of movable parts close to the plasma difficult. The issue might be solved by using gyrotrons able to tune the beam frequency to the desired resonance, but this concept requires transmission windows that work in a given frequency range, such as the Brewster window. It consists of a CVD diamond disc brazed to two copper cuffs at the Brewster angle. The brazing process is carried out at about 800°C and then the temperature is decreased down to room temperature. Diamond and copper have very different thermal expansion coefficients, therefore high stresses build up during the cool down phase that might lead to failure of the disc. Considering also the complex geometry of the window with the skewed position of the disc, analyses are required in the first place to check its feasibility. The cool down phase was simulated by FEM structural analyses for several geometric and constraint configurations of the window. A study of indirect cooling of the window by water was also performed considering a HE11 mode beam. The results are here reported.

  5. Feasibility study report for the 200-BP-1 operable unit

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This feasibility study examines a range of alternatives and provides recommendations for selecting a preferred alternative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965--1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area, groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-levels of contamination with cesium-137, radium-226, strontium-90, thorium-228, and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9{times}10{sup {minus}5}.

  6. Final Report - Wind and Hydro Energy Feasibility Study - June 2011

    Energy Technology Data Exchange (ETDEWEB)

    Jim Zoellick; Richard Engel; Rubin Garcia; Colin Sheppard

    2011-06-17

    This feasibility examined two of the Yurok Tribe's most promising renewable energy resources, wind and hydro, to provide the Tribe detailed, site specific information that will result in a comprehensive business plan sufficient to implement a favorable renewable energy project.

  7. Feasibility study to establish a new value chain

    DEFF Research Database (Denmark)

    Ingrid Herman, Marie; Thai, Thi Minh

    responsibility for value-creation and distribution activities. Finally, the feasibility analysis underlined the importance of reflecting on findings from the previous analyses with regards to set goals in order to identify (mis)matches between expected benefits from the established VC and goals as well...

  8. Pueblo of Laguna Utility Authority Renewable Energy Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Carolyn Stewart, Red Mountain Tribal Energy

    2008-03-31

    The project, “Renewable Energy Feasibility Study” was designed to expand upon previous work done by the Tribe in evaluating utility formation, generation development opportunities, examining options for creating self-sufficiency in energy matters, and integrating energy management with the Tribe’s economic development goals. The evaluation of project locations and economic analysis, led to a focus primarily on solar projects.

  9. Feasibility Study for Aviation Programs at Hudson Valley Community College.

    Science.gov (United States)

    Buckley, Edward P.

    This is a report on a survey to determine the feasibility of establishing aviation training programs at a New York community college. It examines existing sources, and present and future needs for commercial pilots, aviation mechanics, and airline stewardesses. Among the conclusions are the discovery that the aviation industry is on the threshold…

  10. NIR spectrometry for counterfeit drug detection - A feasibility study

    DEFF Research Database (Denmark)

    Rodionova, O.Y.; Houmøller, Lars P.; Pomerantsev, A.L.

    2005-01-01

    Express-methods for detection of counterfeit drugs are of vital necessity. Visual control, dissociating tests or simple color reaction tests reveal only very rough forgeries. The feasibility of information-rich NIR-measurements as an analytical method together with multivariate calibration...

  11. Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites

    Directory of Open Access Journals (Sweden)

    Munguti Kaendi

    2008-01-01

    Full Text Available Abstract Background The Home Management of Malaria (HMM strategy was developed using chloroquine, a now obsolete drug, which has been replaced by artemisinin-based combination therapy (ACT in health facility settings. Incorporation of ACT in HMM would greatly expand access to effective antimalarial therapy by the populations living in underserved areas in malaria endemic countries. The feasibility and acceptability of incorporating ACT in HMM needs to be evaluated. Methods A multi-country study was performed in four district-size sites in Ghana (two sites, Nigeria and Uganda, with populations ranging between 38,000 and 60,000. Community medicine distributors (CMDs were trained in each village to dispense pre-packaged ACT to febrile children aged 6–59 months, after exclusion of danger signs. A community mobilization campaign accompanied the programme. Artesunate-amodiaquine (AA was used in Ghana and artemether-lumefantrine (AL in Nigeria and Uganda. Harmonized qualitative and quantitative data collection methods were used to evaluate CMD performance, caregiver adherence and treatment coverage of febrile children with ACTs obtained from CMDs. Results Some 20,000 fever episodes in young children were treated with ACT by CMDs across the four study sites. Cross-sectional surveys identified 2,190 children with fever in the two preceding weeks, of whom 1,289 (59% were reported to have received ACT from a CMD. Coverage varied from 52% in Nigeria to 75% in Ho District, Ghana. Coverage rates did not appear to vary greatly with the age of the child or with the educational level of the caregiver. A very high proportion of children were reported to have received the first dose on the day of onset or the next day in all four sites (range 86–97%, average 90%. The proportion of children correctly treated in terms of dose and duration was also high (range 74–97%, average 85%. Overall, the proportion of febrile children who received prompt treatment and the

  12. Feasibility study for Boardman River hydroelectric power. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-02-22

    The feasibility of generating additional hydroelectric power from five consecutive existing dams located on the Boardman River in Grand Traverse County and Traverse City, Michigan, was investigated. The potential hydropower production capabilities, in terms of base load power and peak load power, the legal-institutional-environmental constraints, and the economic feasibility, including capital investment, operating costs and maintenance costs, were evaluated for each of the five dam sites individually and as a series of co-dependent facilities. The impact of installing fish passages at each site was analyzed separately. The feasibility assessment utilized the present worth analytical method, considering revenue based on thirty mills/kWh for power, 0.4% general economy escalation rate, and a 6% net income to the municipal utility. The sensitivity of fuel costs increasing at a different rate than the general price-escalation was tested by allowing the increase in fuel costs to vary from 3 to 8% per year. Assuming fuel costs increase at the same rate as the general economy, it is feasible to update, retrofit, renovate, and install hydroelectric generating capacity at Sabin, Boardman and Brown Bridge. Rehabilitation of Union Street and Keystone is also feasible but somewhat less attractive. Operating the dams as a co-dependent system has environmental advantages and can provide additional revenue through peak load power rates. A development plan to implement the above is outlined utilizing an ownership arrangement whereby Grand Traverse County provides easements for Sabin and Boardman Dams. The plan calls for operation of the system by Traverse City.

  13. Livingston Parish Landfill Methane Recovery Project (Feasibility Study)

    Energy Technology Data Exchange (ETDEWEB)

    White, Steven

    2012-11-15

    The Woodside Landfill is owned by Livingston Parish, Louisiana and is operated under contract by Waste Management of Louisiana LLC. This public owner/private operator partnership is commonplace in the solid waste industry today. The landfill has been in operation since approximately 1988 and has a permitted capacity of approximately 41 million cubic yards. Based on an assumed in-place waste density of 0.94 ton per cubic yard, the landfill could have an expected design capacity of 39.3 million tons. The landfill does have an active landfill gas collection and control system (LFGCCS) in place because it meets the minimum thresholds for the New Source Performance Standards (NSPS). The initial LFGCS was installed prior to 2006 and subsequent phases were installed in 2007 and 2010. The Parish received a grant from the United States Department of Energy in 2009 to evaluate the potential for landfill gas recovery and utilization at the Woodside Landfill. This includes a technical and economic feasibility study of a project to install a landfill gas to energy (LFGTE) plant and to compare alternative technologies. The LFGTE plant can take the form of on-site electrical generation, a direct use/medium Btu option, or a high-Btu upgrade technology. The technical evaluation in Section 2 of this report concludes that landfill gas from the Woodside landfill is suitable for recovery and utilization. The financial evaluations in sections 3, 4, and 5 of this report provide financial estimates of the returns for various utilization technologies. The report concludes that the most economically viable project is the Electricity Generation option, subject to the Parish’s ability and willingness to allocate adequate cash for initial capital and/or to obtain debt financing. However, even this option does not present a solid return: by our estimates, there is a 19 year simple payback on the electricity generation option. All of the energy recovery options discussed in this report

  14. Feasibility studies of robot-assisted stroke rehabilitation at clinic and home settings using RUPERT.

    Science.gov (United States)

    Zhang, Hang; Austin, Hiroko; Buchanan, Sharon; Herman, Richard; Koeneman, Jim; He, Jiping

    2011-01-01

    Task based repetitive therapy has been proposed to help stroke survivors to regain functional control of arm movement. We developed a wearable exoskeleton rehabilitation robot with associated control algorithm and safety protection mechanisms, and a graphic user interface that is easy to use and intuitive to patients and therapists, as the framework for automated and customizable robot-assisted rehabilitation system for clinic and home based therapy. The system was tested in two feasibility studies. The first study involved 6 patients to receive therapeutic training during three time weekly clinic visits for 4 weeks. The second study set up the robot-assisted rehabilitation system at patient's house, where the therapeutic training was practiced on a daily base. Two patients were recruited for the home application study. Patients' performances were assessed using clinical evaluation tools, including Wolf Motor Function Test and Fugl Meyer Assessment (FMA), both before and after the training. The performances of patients during the training weeks were also objectively evaluated by using the robot sensory data. © 2011 IEEE

  15. Feasibility, safety, and preliminary efficacy of Low Amplitude Seizure Therapy (LAP-ST): A proof of concept clinical trial in man.

    Science.gov (United States)

    Youssef, Nagy A; Sidhom, Emad

    2017-11-01

    Current pulse amplitude used in clinical ECT may be higher than needed. Reducing pulse amplitude may improve focality of the electric field and thus cognitive adverse effects. Here we examine the feasibility, safety, and whether Low Pulse Amplitude Seizure Therapy (LAP-ST, 0.5-0.6A) minimizes cognitive adverse effects while retaining efficacy. Patients with treatment-resistant primary mood (depressive episodes) or psychotic disorders who were clinically indicated to undergo ECT were offered to be enrolled in an open-label study. The study consisted of a full acute course of LAP-ST under standard anesthesia and muscle relaxation. The primary outcome was feasibility of seizure induction. Clinical outcome measures were: time to reorientation (TRO), Mini Mental State Examination, Montgomery Aberg Depression Scale, and Brief Psychiatric Rating Scale, and Clinical Global Impression Scale. Twenty-two patients consented for enrollment in the study. LAP-ST was feasible, and all patients had seizures in the first session. Participants had a quick orientation with median TRO of 4.5min. Treatment was efficacious for both depressive and psychotic symptoms. Relatively small sample size, non-blinded, and no randomization was performed in this initial proof of concept study. This first human preliminary data of a full course of focal LAP-ST demonstrates that seizure induction is feasible. These results, although preliminary, suggest that the LAP-ST compared to the standard ECT techniques may result in less cognitive side effects, but comparable efficacy. Larger studies are needed to replicate these findings. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Radiofrequency ablation after selective internal radiation therapy with Yttrium90 microspheres in metastatic liver disease-Is it feasible?

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, R.T. [Institute of Clinical Radiology, Ludwig Maximilians-University - Campus Grosshadern, Marchioninstr. 15, 81377 Munich (Germany)], E-mail: rthoffma@med.uni-muenchen.de; Jakobs, T.F. [Institute of Clinical Radiology, Ludwig Maximilians-University - Campus Grosshadern, Marchioninstr. 15, 81377 Munich (Germany); Kubisch, C.H. [Department of Medicine/Gastroenterology, Ludwig Maximilians-University - Campus Grosshadern, Munich (Germany); Stemmler, H.J. [Department of Internal Medicine III/Haematology and Oncology, Ludwig Maximilians-University - Campus Grosshadern, Munich (Germany); Trumm, C. [Institute of Clinical Radiology, Ludwig Maximilians-University - Campus Grosshadern, Marchioninstr. 15, 81377 Munich (Germany); Tatsch, K. [Department of Nuclear Medicine, Ludwig Maximilians-University - Campus Grosshadern, Munich (Germany); Helmberger, T.K. [Institute of Clinical and Diagnostic Radiology and Nuclear Medicine, Munich - Bogenhausen, Munich (Germany); Reiser, M.F. [Institute of Clinical Radiology, Ludwig Maximilians-University - Campus Grosshadern, Marchioninstr. 15, 81377 Munich (Germany)

    2010-04-15

    This retrospective study analyzes, whether patients suffering from extensive hepatic metastatic disease treated with SIRT can become suitable candidates for RFA.Within 38 months 46 patients (26 female, 20 male; age 32-75 years) bearing an extensive hepatic metastatic disease were treated with SIRT. Patients suffered from metastases of breast cancer (16/46), colorectal cancer (CRC) (21/46), neuroendocrine (3/46), and other primary carcinomas (6/46). The indication for SIRT was otherwise untreatable metastases confined to the liver. Forty-three patients received single-session whole-liver radioembolization treatment using Yttrium90 resin microspheres with a mean activity of 2.13 GBq. In 1 patient SIRT was confined to the left and in 2 patients to the right liver lobe. In 3 patients major complications (2/3 gastric ulceration and 1/3 oedematous pancreatitis) and in 24 patients minor complications occurred (acute abdominal/epigastric pain and/or nausea). Follow-up CT and/or MRI were obtained in 44 of 46 patients. In 5 of 44 patients tumor load decreased substantially (3/5 breast cancer, 1/5 CRC and 1/5 pancreatic cancer) making RFA feasible. The patients were referred for RFA after the first 3-month follow-up. RFA of the liver was successful in all cases in terms of complete ablation. In selected patients radioembolization is able to downstage liver metastases to an extent making a subsequent RFA suitable and therefore allows increasing the number of patients with a 'complete response' after a minimally invasive therapy.

  17. Remedial investigation/feasibility study badger army ammunition plant Baraboo, Wisconsin. Volume 3. Feasibility study report (Final)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-08-01

    This Feasibility Study (FS) report for the Badger Army Ammunition Plant (BAAP) in Baraboo, Wisconsin, was prepared by ABB Environmental Services, Inc. (ABB-ES) as a component of Task Order 1 of Contract DAAAl5-91-D-OOO8 with the U.S. Army Environmental Center (USAEC). This report uses the results presented in the Final Remedial Investigation (RI) report (ABB-ES, 1993a) to develop and screen alternatives for remediation of contaminated media at BAAP. The purpose of this FS report is to develop, screen, and evaluate site-specific remedial alternatives to mitigate the impact of site-derived chemicals and ultimately provide protection of human health and the environment. Preferred alternatives for each site are included in this report. Based on previous environmental studies at BAAP, 11 potential hazardous waste sites were ranked according to potential contributions of hazardous chemicals to the environment. These sites were designated as Waste Management Areas because some of the sites contain multiple Solid Waste Management Units (SWMUs). The sites selected to undergo facility assessment and corrective actions are: the Propellant Burning Ground (including Landfill), Deterrent Burning Ground, existing Landfill, Settling Ponds and Spoils Disposal Area, Rocket Paste Area, Oleum Plant and Oleum Plant Pond, Nitroglycerine Pond, old Acid Area, new Acid Area, and Ballistics Pond. The USAEC added an 11th site, the Old Fuel Oil Tank, to the list in October 1989 after discovery of fuel-contaminated soils during excavation of a water line in the vicinity of the old fuel oil tank foundation.

  18. Therapeutic Argentine tango dancing for people living with Parkinson’s disease: a feasibility study

    Directory of Open Access Journals (Sweden)

    Laura M Blandy

    2015-05-01

    Full Text Available Background: Individuals living with Parkinson’s disease (PD can experience a range of movement disorders. Therapeutic dance is enjoyable and thought to improve mobility, balance and well being in some people with PD. The primary objective of this study was to evaluate the feasibility and safety of a 4 week Argentine tango dance program for people with PD. Methods: Six community dwelling individuals with mild-moderate PD were recruited from Parkinson’s support groups, movement disorder clinics and the Parkinson’s disease Association in Australia. To minimise falls risk, participants were required to be less than 75 years of age and physically independent (Hoehn and Yahr stages I-III. They were also required to speak English. Participants attended a 1 hour dance class at a dance studio twice per week for 4 weeks. A professional dance instructor led and choreographed the classes. Physiotherapists were present to assist participants during the class and served as dance partners as necessary. The primary outcome was feasibility which was determined by measures of recruitment, adherence, attrition, safety (falls, near misses and adverse events and resource requirements. Secondary measures included the Beck Depression Inventory and the Euroqol-5D, administered at baseline and post intervention. Therapy outcomes pre and post-intervention were analysed descriptively as medians and inter-quartile ranges and using Wilcoxon matched pair signed-rank tests.Results: The Argentine tango dance intervention was shown to be safe, with no adverse events. Adherence to the dance program was 89%. Depression scores improved after intervention (p=0.04. Some challenges were associated with the need to quickly recruitment participants and supplying physiotherapists to act as dance partners. Conclusion: The program was shown to be feasible and safe for people with mild to moderately severe PD.

  19. 78 FR 57624 - Availability of a Draft Integrated Feasibility Report (Feasibility Study/Environmental Impact...

    Science.gov (United States)

    2013-09-19

    .../Environmental Impact Report (EIS/EIR) for the Los Angeles River Ecosystem Restoration Study, Los Angeles County, CA, for review and comment. The study evaluates alternatives for the purpose of restoring 11 miles of.... Restoration also includes the reintroduction of ecological and physical processes such as a more natural...

  20. Using auriculotherapy for osteoarthritic knee among elders: a double-blinded randomised feasibility study.

    Science.gov (United States)

    Suen, Lorna K P; Yeh, Chao Hsing; Yeung, Simon K W

    2016-07-29

    Osteoarthritic knee (OA knee) is a common condition in the elderly. Exploration of non-invasive complementary therapies for OA knee is warranted given the limitations of pharmacologic therapies. Auriculotherapy (AT) is a therapeutic method in which specific points on the auricle are stimulated to treat various disorders of the body, and the therapeutic value and synergistic effect of laser auriculotherapy (LAT) when combined with magneto-auriculotherapy (MAT) merits further investigation. This study adopted a double-blinded four-arm randomized placebo design. The aims of study are (1) to assess the feasibility of AT among elders with OA knee in a future large-scale study, including the use of blinding in subjects and evaluators, acceptance of treatment protocol, and estimating the effect size and attrition rate; and (2) to evaluate the preliminary effect of AT in elders with OA knee. Subjects were randomly divided into four groups with different modes of AT with/without placebo objects. A total of 43 subjects completed the 6-week intervention and post-assessment. Assessments included a numerical rating scale of pain (NRS), the timed-up-and-go test (TUGT), and standard goniometer measurements during knee flexion and extension, Kruskal-Wallis test was used to evaluate differences among groups, and Wilcoxon sign-ranked test for examining within-group comparison. Preliminary results indicated the absence of differences in the NRS, TUGT, and active/passive knee flexion and extension at baseline, as well as post-therapy, between the four groups. Even though the differences of these parameters between groups were not significant, the relative differences of NRS and TUGT in subjects who received combined MAT plus LAT were higher than those treated with MAT or LAT alone, or the placebo group. Four of the six parameters demonstrated significant within group differences in subjects who received MAT and/or LAT, whereas no significant differences were found in the placebo group

  1. Cherenkov luminescence measurements with digital silicon photomultipliers: a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Ciarrocchi, Esther; Belcari, Nicola; Guerra, Alberto Del [Department of Physics, University of Pisa, Pisa (Italy); INFN, section of Pisa, Pisa (Italy); Cherry, Simon R. [Department of Biomedical Engineering, University of California, Davis, CA (United States); Lehnert, Adrienne; Hunter, William C. J.; McDougald, Wendy; Miyaoka, Robert S.; Kinahan, Paul E. [Department of Radiology, University of Washington, Seattle, WA (United States)

    2015-11-16

    A feasibility study was done to assess the capability of digital silicon photomultipliers to measure the Cherenkov luminescence emitted by a β source. Cherenkov luminescence imaging (CLI) is possible with a charge coupled device (CCD) based technology, but a stand-alone technique for quantitative activity measurements based on Cherenkov luminescence has not yet been developed. Silicon photomultipliers (SiPMs) are photon counting devices with a fast impulse response and can potentially be used to quantify β-emitting radiotracer distributions by CLI. In this study, a Philips digital photon counting (PDPC) silicon photomultiplier detector was evaluated for measuring Cherenkov luminescence. The PDPC detector is a matrix of avalanche photodiodes, which were read one at a time in a dark count map (DCM) measurement mode (much like a CCD). This reduces the device active area but allows the information from a single avalanche photodiode to be preserved, which is not possible with analog SiPMs. An algorithm to reject the noisiest photodiodes and to correct the measured count rate for the dark current was developed. The results show that, in DCM mode and at (10–13) °C, the PDPC has a dynamic response to different levels of Cherenkov luminescence emitted by a β source and transmitted through an opaque medium. This suggests the potential for this approach to provide quantitative activity measurements. Interestingly, the potential use of the PDPC in DCM mode for direct imaging of Cherenkov luminescence, as a opposed to a scalar measurement device, was also apparent. We showed that a PDPC tile in DCM mode is able to detect and image a β source through its Cherenkov radiation emission. The detector’s dynamic response to different levels of radiation suggests its potential quantitative capabilities, and the DCM mode allows imaging with a better spatial resolution than the conventional event-triggered mode. Finally, the same acquisition procedure and data processing could

  2. Laparoscopic anatrophic nephrolithotomy: feasibility study in a chronic porcine model.

    Science.gov (United States)

    Kaouk, Jihad H; Gill, Inderbir S; Desai, Mihir M; Banks, Kevin L W; Raja, Shanker S; Skacel, Marek; Sung, Gyung Tak

    2003-02-01

    PURPOSE Anatrophic nephrolithotomy performed via open surgery involves incising the renal parenchyma along an avascular plane to remove a large, complex renal stone. We determined the feasibility of performing laparoscopic anatrophic nephrolithotomy in a survival porcine model. Furthermore, we present a novel technique of creating a staghorn calculus in the porcine model. MATERIALS AND METHODS After developing the technique in 3 pigs the survival study was performed in 10 consecutive animals. The procedure comprised 2 aspects. 1) We developed an animal model for staghorn calculi by retrograde injection of polyurethane (Fomo Products, Inc., Norton, Ohio) into the renal pelvis through a ureteral catheter. For a 2-week period the staghorn calculus was allowed to create hydronephrosis. 2) Laparoscopic anatrophic nephrolithotomy was done, involving control of the renal artery and vein, in situ renal hypothermia with ice slush in 1 animal, lateral renal parenchymal incision, stone extraction and suture repair of the incised collecting system and renal parenchyma. RESULTS Synthetic stone formation and laparoscopic anatrophic nephrolithotomy were successful in all 10 animals, including 1 that underwent staged bilateral anatrophic nephrolithotomy. Mean operative time for anatrophic nephrolithotomy was 125 minutes. Mean blood loss was 68 cc and mean warm ischemia time was 30 minutes (range 23 to 39). A residual small pelvicaliceal calculus was noted postoperatively in the initial 3 cases only. Thereafter, routine intraoperative ultrasonography and flexible endoscopy were done for stone localization, resulting in a stone-free rate of 100% in all 7 remaining animals. Diethylenetriamine pentaacetic acid renal scans documented improvement in the glomerular filtration rate from a mean of 26.4 ml. per minute after stone creation and hydronephrosis to 54.8 ml. per minute 4 to 5 weeks after laparoscopic anatrophic nephrolithotomy. CONCLUSIONS Laparoscopic techniques can be applied

  3. Sugarcane biomass for power generation in Cuba - Feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    We analyze technical and economic feasibility of a 17 MW power plant in Cuba fuelled by sugarcane biomass. The power plant makes use of the BIG-GT gasification technology. The highly energy efficient BIG-GT technology is generally seen as promising, but it has not as yet been commercially proven. We conclude that the plant is technically and commercially feasible given a grant element of 38 per cent of its capital cost. The grant estimate assumes an electricity price of 5.2 cent/kWh, but is highly sensitive to the price level. The grant is lower than the value of non-commercial benefits of the plant. Therefore the plant passes the cost-benefit test. The most important benefit of the plant may be its demonstration value, which contributes to reducing costs of future plants. Costs are likely to be halved as more plants using the same technology are developed. (Author)

  4. FEASIBILITY STUDY OF PRESSURE PULSING PIPELINE UNPLUGGING TECHNOLOGIES FOR HANFORD

    Energy Technology Data Exchange (ETDEWEB)

    Servin, M. A. [Washington River Protection Solutions, LLC, Richland, WA (United States); Garfield, J. S. [AEM Consulting, LLC (United States); Golcar, G. R. [AEM Consulting, LLC (United States)

    2012-12-20

    The ability to unplug key waste transfer routes is generally essential for successful tank farms operations. All transfer lines run the risk of plugging but the cross site transfer line poses increased risk due to its longer length. The loss of a transfer route needed to support the waste feed delivery mission impacts the cost and schedule of the Hanford clean up mission. This report addresses the engineering feasibility for two pressure pulse technologies, which are similar in concept, for pipeline unplugging.

  5. Long-range eye tracking: A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Jayaweera, S.K.; Lu, Shin-yee

    1994-08-24

    The design considerations for a long-range Purkinje effects based video tracking system using current technology is presented. Past work, current experiments, and future directions are thoroughly discussed, with an emphasis on digital signal processing techniques and obstacles. It has been determined that while a robust, efficient, long-range, and non-invasive eye tracking system will be difficult to develop, such as a project is indeed feasible.

  6. Feasibility study--computerized application of the hazardous material regulations

    Energy Technology Data Exchange (ETDEWEB)

    Ferrada, J.J.; Green, V.M.; Rawl, R.R.

    1992-09-01

    The feasibility of developing a full expert system for transportation and packaging of hazardous and radioactive materials was initiated within the framework of three subtasks: (1) analysis of commercial packages related to regulation scanning, (2) analysis of computer languages to develop the expert system, and (3) development of expert system prototypes. The strategy to develop the latter subtask was to first,develop modules to capture the knowledge of different areas of transportation and packaging and second, to analyze the feasibility of appending these different modules in one final full package. The individual modules development contemplated one prototype for transporting and packaging of radioactive material and another for transporting hazardous chemical materials. In the event that it is not feasible to link these two packages, the modules can always be used as stand-alone tools, or linked as a single package with some restrictions in their applicability. The work done during this fiscal year has focused on developing a prototype for transporting radioactive materials.

  7. Fidelity to a motivational interviewing intervention for those with post-stroke aphasia: a small-scale feasibility study.

    Science.gov (United States)

    Holland, Emma-Joy; Watkins, Caroline L; Boaden, Elizabeth; Lightbody, Catherine E

    2018-01-01

    Depression after stroke is common, and talk-based psychological therapies can be a useful intervention. While a third of stroke survivors will experience communication difficulties impeding participation in talk-based therapies, little guidance exists to guide delivery for those with aphasia. We need to understand how to adapt talk-based therapies in the presence of aphasia. This study aimed to explore the feasibility of motivational interviewing (MI) in people with post-stroke aphasia. In a small-scale feasibility study, consecutive patients admitted to an acute stroke ward were screened for eligibility. People with moderate to severe aphasia were eligible. Those consenting received an intervention consisting of up to eight MI sessions delivered twice per week over four weeks. Sessions were modified using aids and adaptations for aphasia. Session quality was measured using the Motivational Interviewing Skills Code (MISC) to assess MI fidelity. Three consenting patients identified early post-stroke took part; one male and two females ages ranging between 40s and 80s. Participants attended between five and eight MI sessions over four weeks. Aids and adaptations included visual cues, rating scales, and modified reflections incorporating verbal and non-verbal behaviors. Sessions were tailored to individual participant need. Threshold MISC ratings could be achieved for all participants however, ratings were reduced when aids and adaptations were not used. This small-scale feasibility study suggests that it is feasible to adapt MI for people with moderate to severe post-stroke aphasia. These findings merit further exploration of adapted MI as an intervention for this patient group.

  8. A feasibility study for an International Year of Landcare

    Science.gov (United States)

    Mutota, E.; Arnalds, A.

    2009-04-01

    Human-induced activities place enormous pressures on the land worldwide, creating competition and conflict, and suboptimal use of the land. Climate change, loss of biodiversity and land degradation leads to decreasing productivity, food and water shortages, and reduced economic benefits, among others. In order to address these challenges and achieve sustainability goals, the need to change the way global resources are being utilized is crucial. A holistic and integrated community-based approach such as Landcare could be a viable approach to meet this worldwide challenge. Landcare is about committed people working together on land rehabilitation and restoration projects at the local level, transforming attitudes and stimulating new ideas among land users, generating support and building partnerships between and among local communities, governments and the private sector. Landcare initiatives have grown in a number of countries where success stories of actions on the ground clearly show the wider application of the Landcare approach in resolving many of the world's environmental problems and livelihood challenges. However, the potential of Landcare have not yet been widely exploited on a scale that really matters—as local actions build up towards global progress, there is more scope for unified efforts towards a global Landcare movement. Following the recommendation given at the International Forum on Soils, Society and Global Change in 2007 in Iceland (http://www.iisd.ca/YMB/SDFSS/), an International Year of Landcare should be established. Such a year would bring into focus efforts to build local capacity and share knowledge and experiences between provinces, countries and continents on Landcare. Additionally, holding a year concerned with Landcare would greatly contribute to the attainment of the Millennium Development Goals, the UN environmental conventions and many other sustainability goals. Our study supports the notion that Landcare offers a robust platform

  9. Seabed Filter Feasibility Study of Om Almisk Island

    KAUST Repository

    Sesler, Kathryn

    2012-06-01

    Freshwater access has always been and is continuing to be a severe problem in desert coastal regions, despite the fact that they have an unlimited supply of easily accessible saline water. Water desalination plants are well established and heavily relied upon throughout the Middle East, Saudi Arabia in particular. However, water desalination tends to be a very expensive and energy intensive solution to the problem. The transition from using open water intake systems and all of the pretreatment processes that they require, to using seabed water filters as an intake, would potentially reduce the lifetime costs, energy consumption, and environmental impacts commonly associated with water desalination. This is because the filtration process that the seabed filter generates, serves as sufficient pretreatment for seawater as well as eliminating any risk of entrainment or impingement of marine organisms. The main objective of this research is to conduct a feasibility study on Om Almisk Island, an island off the coast of King Abdullah University of Science and Technology (KAUST), to determine if it would be a suitable location to construct a seabed water filter as a replacement for the current open water intake. The Om Almisk Island site was evaluated through collection of sand samples over a radial grid around Om Almisk Island and sample analysis using grain size distribution, porosity, and hydraulic conductivity. The lack of mud, high hydraulic conductivity, proximity to KAUST, and the shallow waters of the sandy apron surrounding Om Almisk Island make this an ideal location for a seabed water filter to be used as an intake and pretreatment for the KAUST desalination plant. This location also has low tide change and the presence of benthic macrofauna to create bioturbation in the sediments, which could inhibit the growth of a schmutzdecke. If this biological layer forms, it could drastically reduce the hydraulic conductivity of the system. Due to the high hydraulic

  10. Feasibility of the modified constraint-induced movement therapy in patients with median and ulnar nerve injuries: a single-subject A-B-A design.

    Science.gov (United States)

    Rostami, Hamid Reza; Khayatzadeh Mahany, Mohammad; Yarmohammadi, Narjes

    2015-03-01

    The present study aimed to determine feasibility and efficacy of the modified constraint-induced movement therapy on upper limb function in patients with median and ulnar nerve injuries. Single subject, A1-B-A2 design. Occupational therapy outpatient clinic. A convenience sample including three patients with median and ulnar nerve injuries. Modified constraint-induced movement therapy as follows: an intensive practice with affected hand for one hour daily, five days per week, for four weeks while the healthy hand was immobilised using a splint during waking hours. Semmes-Weinstein monofilaments, Box and block test, and Disabilities of the arm, shoulder, and hand questionnaire. A blinded assessor administered the assessments in a random order across sessions, six times for the baseline phase (A1), four times for the intervention phase (B), and four times for the withdrawal phase (A2). Touch perception did not occur after the intervention phase at the pulp of the index and little fingers. Manual dexterity and motor ability significantly improved (Box and block change scores exceeded the minimal detectable change of 5.5 blocks), as well performance in activities of daily living during real life (Disabilities of the arm, shoulder, and hand questionnaire change scores exceeded the clinically important change value of 20.9 points). These improvements maintained and even enhanced during the withdrawal phase. Modified constraint-induced movement therapy is a feasible and useful adjunct to rehabilitation of the patients with median and ulnar nerve injuries that warrants further research. © The Author(s) 2014.

  11. Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans

    Directory of Open Access Journals (Sweden)

    Caroline Seebach

    2016-11-01

    Full Text Available Abstract Background Local implantation of ex vivo concentrated, washed and filtrated human bone marrow-derived mononuclear cells (BMC seeded onto β-tricalciumphosphate (TCP significantly enhanced bone healing in a preclinical segmental defect model. Based on these results, we evaluated in a first clinical phase-I trial safety and feasibility of augmentation with preoperatively isolated autologous BMC seeded onto β-TCP in combination with angle stable plate fixation for the therapy of proximal humeral fractures as a potential alternative to autologous bone graft from the iliac crest. Methods 10 patients were enrolled to assess whether cell therapy with 1.3 × 106 autologous BMC/ml/ml β-TCP, collected on the day preceding the definitive surgery, is safe and feasible when seeded onto β-TCP in patients with a proximal humeral fracture. 5 follow-up visits for clinical and radiological controls up to 12 weeks were performed. Results β-tricalciumphosphate fortification with BMC was feasible and safe; specifically, neither morbidity at the harvest site nor at the surgical wound site were observed. Neither local nor systemic inflammation was noted. All fractures healed within the observation time without secondary dislocation. Three adverse events were reported: one case each of abdominal wall shingles, tendon loosening and initial screw perforation, none of which presumed related to the IND. Conclusions Cell therapy with autologous BMC for bone regeneration appeared to be safe and feasible with no drug-related adverse reactions being described to date. The impression of efficacy was given, although the study was not powered nor controlled to detect such. A clinical trial phase-II will be forthcoming in order to formally test the clinical benefit of BMC-laden β-TCP for PHF patients. Trial registration The study was registered in the European Clinical Trial Register as EudraCT No. 2012-004037-17. Date of registration 30th of August 2012. Informed

  12. [Feasibility of "no tube no fasting" therapy in thoracolaparoscopic oesophagectomy for patients with oesophageal cancer].

    Science.gov (United States)

    Sun, Haibo; Li, Yin; Liu, Xianben; Wang, Zongfei; Zhang, Ruixiang; Qin, Jianjun; Wei, Xiufeng; Leng, Changsen; Zhu, Junwei; Chen, Xiankai; Wu, Zhao; Yu, Yongkui; Li, Haomiao

    2014-09-01

    To investigate the feasibility of no nasogastric intubation and early oral feeding at will after thoracolaparoscopic esophagectomy for patients with esophageal cancer. Between January 2013 and January 2014, the feasibility of no nasogastric intubation and early oral feeding at postoperative day(POD) 1 after thoracolaparoscopic esophagectomy was prospectively investigated in 156 patients (trial group) with esophageal cancer in the Henan Cancer Hospital. One hundred and sixty patients previously managed in the same unit who were treated routinely after thoracolaparoscopic esophagectomy were served as control group. Of 156 patients of trial group, 6(3.8%) patients could not take food early as planned because of postoperative complications. The overall complication rate in trial group was 19.2%(30/156), which was 25.0%(30/160) in control group (P=0.217). The anastomotic leakage in trial group and control group was 2.6%(4/156) and 4.3%(7/160) respectively (P=0.380). Compared with control group, time to first flatus [(2.1±0.9) d vs. (3.3±1.1) d, P<0.001], bowel movement [(4.4±1.3) d vs. (6.6±1.0) d, P<0.001] and postoperative hospital stay [(8.3±3.2) d vs. (10.4±3.6) d, P<0.001] were significantly shorter in trial group. No nasogastric intubation and early oral feeding postoperatively in patients with thoracolaparoscopic esophagectomy is feasible and safe. This management can shorten postoperative hospital stay and fasten postoperative bowel function recovery.

  13. Weekly Cisplatin and Volumetric-Modulated Arc Therapy With Simultaneous Integrated Boost for Radical Treatment of Advanced Cervical Cancer in Elderly Patients: Feasibility and Clinical Preliminary Results.

    Science.gov (United States)

    Mazzola, Rosario; Ricchetti, Francesco; Fiorentino, Alba; Levra, Niccolò Giaj; Fersino, Sergio; Di Paola, Gioacchino; Ruggieri, Ruggero; Alongi, Filippo

    2017-06-01

    To evaluate the feasibility and clinical preliminary results of weekly cisplatin and volumetric-modulated arc therapy to the pelvis with simultaneous integrated boost to macroscopic disease in a cohort of elderly patients. Inclusion criteria of this prospective study were age ≥70 years, Karnofsky performance status 70 to 100, locally advanced histologically proven squamous cervical carcinoma, and patients unable to undergo brachytherapy. Radiation doses prescribed were 66 Gy to the macroscopic disease and 54 Gy to the pelvic nodes in 30 fractions. Weekly cisplatin dose was 40 mg/mq. A total of 30 patients were recruited. Median follow-up was 32 months (range: 8-48 months). Median age was 72 years (range: 70-84 years). The 3-year overall survival and local control were 93% and 80%, respectively. The median time to progression was 24 months (range: 6-30 months). Analyzing clinical outcome grouping based on the stage of disease, II versus III, the 3-year overall survival was 100% and 85%, respectively. The 3-year local control was 91% for stage II and 67% for stage III. Acute and late toxicities were acceptable without severe events. Weekly cisplatin and volumetric-modulated arc therapy-simultaneous integrated boost for radical treatment of advanced cervical cancer in the current cohort of elderly patients were feasible. Long-term results and prospective randomized trials are advocated.

  14. Feasibility study of rapid opioid rotation and titration.

    Science.gov (United States)

    Korkmazsky, Marina; Ghandehari, Javid; Sanchez, Angela; Lin, Hung-Mo; Lin, Huong-Mo; Pappagallo, Marco

    2011-01-01

    Opioid guidelines recommend opioid rotation and switching for patients who do not achieve adequate pain relief or who experience intolerable adverse events (AEs) with their current opioid. However, specific recommendations and protocols for opioid rotation are lacking, making the practice time consuming and difficult for primary care physicians to accomplish independently or coordinate with a pain specialist. To assess the safety and feasibility of using 24-hour intravenous patient-controlled analgesia (IV-PCA) to achieve rapid opioid rotation and titration (RORT). Open-label pilot study. Hospital research center. At admission, patients (aged ≥ 18 years) with treatment-refractory chronic pain who were taking morphine or oxycodone for ≥ 3 months and had pain scores ≥ 4 on a 10-point scale, underwent opioid rotation to oral oxymorphone extended release (ER). They also received IV-PCA oxymorphone for 24 hours as needed. At discharge, the participants were taking oral oxymorphone ER with oxymorphone immediate release (IR) as needed based on their total 24-hour oral plus IV-PCA oxymorphone use. During a 2-week follow-up, their oxymorphone usage was titrated as needed. Main outcome measures were AEs, Patient Global Impression of Change (PGIC), Brief Pain Inventory (0 = no pain/interference, 10 = worst pain/complete interference), treatment satisfaction, and change in oxymorphone dose. Twelve patients enrolled and completed the 24-hour IV-PCA; 10 completed the 2-week follow-up post-24-hour IV-PCA. PGIC status improved by 12 hours (odds ratio [OR], 0.19, 95% CI, 0.08 - 0.44; P < 0.001), and both PGIC status and activity scores improved by 24 hours (OR, 0.23, 95% CI, 0.09 - 0.55; P = 0.001; OR, 0.49, 95% CI, 0.25 - 0.96; P = 0.04, respectively) and 2 weeks (OR, 0.14, 95% CI, 0.04 - 0.46; P = 0.001; OR, 0.21, 95% CI, 0.06 - 0.72; P = 0.01) versus 6 hours. During the 24-hour IV-PCA time period, 6 of 10 patients accomplished ≥ 50% of their overall dose titration. At 2

  15. Combination therapy with interferon and JAK1-2 inhibitor is feasible

    DEFF Research Database (Denmark)

    Bjørn, M E; de Stricker, K; Kjær, L

    2014-01-01

    We report a 55 year old woman with post-ET PV for 12 years, who experienced resolution of severe constitutional symptoms within 3 days, a marked reduction in splenomegaly and a rapid decline in the JAK2V617F allele burden during combination therapy with interferon-alpha2a and ruxolitinib. Within ...

  16. Testing the feasibility of the Dignity Therapy interview: adaptation for the Danish culture

    DEFF Research Database (Denmark)

    Houmann, Lise J; Rydahl-Hansen, Susan; Chochinov, Harvey M

    2010-01-01

    ABSTRACT: BACKGROUND: 'Dignity Therapy' (DT) is a brief, flexible intervention, which allows patients to complete an interview and create a document regarding their life, identity and what they want to leave in writing for their loved ones. DT is based on the DT Question Protocol. Developed...

  17. Brief Cognitive-Behavioral Therapy for Anxious Youth: Feasibility and Initial Outcomes

    Science.gov (United States)

    Crawley, Sarah A.; Kendall, Philip C.; Benjamin, Courtney L.; Brodman, Douglas M.; Wei, Chiaying; Beidas, Rinad S.; Podell, Jennifer L.; Mauro, Christian

    2013-01-01

    We developed and evaluated a brief (8-session) version of cognitive-behavioral therapy (BCBT) for anxiety disorders in youth ages 6 to 13. This report describes the design and development of the BCBT program and intervention materials (therapist treatment manual and child treatment workbook) and an initial evaluation of child treatment outcomes.…

  18. Failure Modes and Effects Analysis (FMEA) Assistant Tool Feasibility Study

    Science.gov (United States)

    Flores, Melissa D.; Malin, Jane T.; Fleming, Land D.

    2013-09-01

    An effort to determine the feasibility of a software tool to assist in Failure Modes and Effects Analysis (FMEA) has been completed. This new and unique approach to FMEA uses model based systems engineering concepts to recommend failure modes, causes, and effects to the user after they have made several selections from pick lists about a component's functions and inputs/outputs. Recommendations are made based on a library using common failure modes identified over the course of several major human spaceflight programs. However, the tool could be adapted for use in a wide range of applications from NASA to the energy industry.

  19. Feasibility study of 5MW superconducting wind turbine generator

    DEFF Research Database (Denmark)

    Abrahamsen, Asger Bech; Jensen, Bogi Bech; Seiler, E.

    2011-01-01

    The feasibility of installing a direct drive superconducting generator in the 5MW reference offshore wind turbine of the National Renewable Energy Laboratory (NREL) has been examined. The engineering current densities Je obtained in a series of race track coils have been combined with magnetization...... measurements to estimate the properties of suitable field coils for a synchronous generator, which is more light weight than the conventional used combination of a gear box and a fast rotating generator. An analytical model and finite element simulations have been used to estimate the active mass of generators...

  20. Operation Brain Trauma Therapy Extended Studies

    Science.gov (United States)

    2015-05-01

    studies with two additional therapies , the aquaporin-4 antagonist AER -271 and the putative cognitive enhancing drug amantadine. AER -271 failed...results have been obtained and are being analyzed. Therapies 8 and 9 ( AER -271 and amantadine) are in various stages of investigation across the...development of cerebral edema. Insults and behavioral testing of therapy 8, AER -271 have been completed and data are being analyzed. Therapy 9, amantadine is

  1. Pediatricians, well-baby visits, and Video Intervention Therapy: feasibility of a video-feedback infant mental health support intervention in a pediatric primary health care setting.

    Directory of Open Access Journals (Sweden)

    Sergio eFacchini

    2016-02-01

    Full Text Available This case series study evaluated the feasibility and acceptability of a behavioral/cognitive psychological intervention in a pediatric primary health care setting during standard well-baby visits. The aim of the intervention was to support caregivers’ sensitivity and mentalization in order to promote infant mental health. Four neonates from birth to eight months were consecutively enrolled to test a short video-feedback intervention (Primary Care - Video Intervention Therapy, an adaptation of George Downing's Video Intervention Therapy to primary care conducted by a pediatrician.The five minute interaction recording and the video-feedback session were performed during the same well-baby visit and in the same pediatrician's office where the physical examination was conducted. During the study period, six video-feedback sessions were performed for each baby at different ages (1, 2, 3, 4, 6, 8 months. Filmed and discussed were a series of different interactional situations: touch, cry, affective matching, descriptive language, feeding, separation and autonomy.The intervention was easily accepted and much appreciated by all four families enrolled. This study aimed to answer a dilemma which pediatric providers generally face: if the provider wishes to respond to not only physical but also infant mental health issues, how on a practical level can this be done? This case series study indicates that Primary Care - Video Intervention Therapy deserves to be seen as a promising new tool for such a purpose.

  2. Spirometry in elderly laryngectomized patients: A feasibility study.

    Science.gov (United States)

    Izzo, Alessandro; Perrotta, Fabio; Cennamo, Antonio; Cerqua,