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Sample records for tf joint design

  1. FLOWTRAN-TF software design

    Energy Technology Data Exchange (ETDEWEB)

    Aleman, S.E.; Flach, G.P.; Hamm, L.L.; Lee, S.Y.; Smith, F.G. III.

    1993-02-01

    FLOWTRAN-TF was created to analyze an individual Mk22 fuel assembly during a large break Loss Of Coolant Accident (LOCA) scenario involving the Savannah River Site K-reactor after the initial few seconds of the transient. During the initial few seconds reactor cooling is limited by the static or Ledinegg flow instability phenomenon. The predecessor FLOWTRAN code was developed to analyze this portion of a LOCA. In the several seconds following the break, a significant fraction of the reactor coolant inventory leaks out the break, Emergency Cooling System (ECS) flow is initiated, and air enters the primary coolant circulation loops. Reactor fuel assemblies are cooled by a low flowrate air-water downflow. Existing commercial nuclear industry thermal-hydraulic codes were judged inadequate for detailed modeling of a Mk22 fuel assembly because the application involves a ribbed annular geometry, low pressure, downflow and an air-water mixture. FLOWTRAN-TF is a two-phase thermal-hydraulics code of similar technology to existing commercial codes such as RELAP and TRAC but customized for Savannah River Site applications. The main features and capabilities of FLOWTRAN-TF are detailed Mk22 fuel assembly ribbed annular geometry; conjugate heat transfer; detailed neutronic power distribution; three-dimensional heat conduction in Mk22 fuel and target tubes; two-dimensional coolant flow in channels (axial, azimuthal); single-phase and/or two-phase fluid (gas, liquid and/or gas-liquid); two-component (air, water); constitutive models applicable to low pressure air-water downflow in ribbed annular channels. The design of FLOWTRAN-TF is described in detail in this report which serves as the Software Design Report in accordance with Quality Assurance Procedure IV-4, Rev. 0 Software Design and Implementation'' in the 1Q34 manual.

  2. FLOWTRAN-TF software design

    Energy Technology Data Exchange (ETDEWEB)

    Aleman, S.E.; Flach, G.P.; Hamm, L.L.; Lee, S.Y.; Smith, F.G. III

    1993-02-01

    FLOWTRAN-TF was created to analyze an individual Mk22 fuel assembly during a large break Loss Of Coolant Accident (LOCA) scenario involving the Savannah River Site K-reactor after the initial few seconds of the transient. During the initial few seconds reactor cooling is limited by the static or Ledinegg flow instability phenomenon. The predecessor FLOWTRAN code was developed to analyze this portion of a LOCA. In the several seconds following the break, a significant fraction of the reactor coolant inventory leaks out the break, Emergency Cooling System (ECS) flow is initiated, and air enters the primary coolant circulation loops. Reactor fuel assemblies are cooled by a low flowrate air-water downflow. Existing commercial nuclear industry thermal-hydraulic codes were judged inadequate for detailed modeling of a Mk22 fuel assembly because the application involves a ribbed annular geometry, low pressure, downflow and an air-water mixture. FLOWTRAN-TF is a two-phase thermal-hydraulics code of similar technology to existing commercial codes such as RELAP and TRAC but customized for Savannah River Site applications. The main features and capabilities of FLOWTRAN-TF are detailed Mk22 fuel assembly ribbed annular geometry; conjugate heat transfer; detailed neutronic power distribution; three-dimensional heat conduction in Mk22 fuel and target tubes; two-dimensional coolant flow in channels (axial, azimuthal); single-phase and/or two-phase fluid (gas, liquid and/or gas-liquid); two-component (air, water); constitutive models applicable to low pressure air-water downflow in ribbed annular channels. The design of FLOWTRAN-TF is described in detail in this report which serves as the Software Design Report in accordance with Quality Assurance Procedure IV-4, Rev. 0 ``Software Design and Implementation`` in the 1Q34 manual.

  3. Analysis of NSTX TF Joint Voltage Measurements

    Energy Technology Data Exchange (ETDEWEB)

    R, Woolley

    2005-10-07

    This report presents findings of analyses of recorded current and voltage data associated with 72 electrical joints operating at high current and high mechanical stress. The analysis goal was to characterize the mechanical behavior of each joint and thus evaluate its mechanical supports. The joints are part of the toroidal field (TF) magnet system of the National Spherical Torus Experiment (NSTX) pulsed plasma device operating at the Princeton Plasma Physics Laboratory (PPPL). Since there is not sufficient space near the joints for much traditional mechanical instrumentation, small voltage probes were installed on each joint and their voltage monitoring waveforms have been recorded on sampling digitizers during each NSTX ''shot''.

  4. Detailed design studies at CEA for JT-60SA TF coils

    Energy Technology Data Exchange (ETDEWEB)

    Decool, P., E-mail: patrick.decool@cea.fr [CEA, IRFM F-13108 St-Paul-Lez-Durance Cedex (France); Marechal, J.L.; Portafaix, C.; Lacroix, B.; Gros, G.; Verger, J.M. [CEA, IRFM F-13108 St-Paul-Lez-Durance Cedex (France)

    2011-10-15

    Following a first conceptual design activity in which the general design of the JT-60SA TF system was defined and frozen in agreement with all the participants in the project (CEA, ENEA, F4E), a second phase had to be launched to deal with the detailed design. In this paper, we present the work performed at CEA on the TF coil design during this second phase. Part of this work, concerns the determination of conductor hydraulic performances during operation as well as in factory. The thermohydraulic of the conductor was also assessed to confirm the need of helium inlets and a specific design was developed and qualified to be compatible with the available hydraulic performance of the cryoplant. The mechanical behavior is still to be assessed and qualified. Last but not least, the inner electrical joints of the coil have been modified with respect to the original twin-box design developed by CEA for the ITER coils in order to simplify the fabrication process. A dedicated qualification program for their manufacture is ongoing.

  5. Impact of several reactor features on TF coil design for TPSS

    Energy Technology Data Exchange (ETDEWEB)

    Miller, J.R.

    1986-01-10

    Limits of acceptable radiation levels relative to winding pack current densities in the toroidal field (TF) coils is given for relevant reactor designs. Force cooled conductors are stipulated in this study. The maximum field which can be supported while maintaining adequate stability and the ability to protect the coils in the event of a quench to end of the machine life is reported to be 6T. TF configuration, winding pack design, heat removal, stability, copper fraction and effect of damage, limiting current, and protection are discussed. 12 refs., 2 tabs. (WRF)

  6. Design considerations for the TF center conductor post for the Ignition Spherical Torus (IST)

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, G.R.; Haines, J.R.

    1986-01-01

    A trade-off study has been carried out to compare the differential costs of using high-strength alloy copper versus oxygen-free, high-conductivity (OFHC) copper for the center legs of the toroidal field (TF) coils of an Ignition Spherical Torus (IST). The electrical heating, temperatures, stresses, cooling requirements, material costs, pump costs, and power to drive the TF coils and pumps are all assessed for both materials for a range of compact tokamak reactors. The alloy copper material is found to result in a more compact reactor and to allow use of current densities of up to 170 MA/mS versus 40 MA/mS for the OFHC copper. The OFHC conductor system with high current density is $24 million less expensive than more conventional copper systems with 30 MA/mS. The alloy copper system costs $32 million less than conventional systems. Therefore, the alloy system offers a net savings of $8 million compared to the 50% cold-worked OFHC copper system. Although the savings are a significant fraction of the center conductor post cost, they are relatively insignificant in terms of the total device cost. It is concluded that the use of alloy copper contributes very little to the economic or technical viability of the compact IST. It is recommended that a similar systematic approach be applied to evaluating coil material and current density trade-offs for other compact copper-TF-coil tokamak designs. 9 refs., 13 figs., 13 tabs.

  7. Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system

    Energy Technology Data Exchange (ETDEWEB)

    Zaidi, H; Ratib, O [Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211 Geneva (Switzerland); Ojha, N; Morich, M; Griesmer, J; Hu, Z; Maniawski, P; Shao, L [Philips Healthcare, Cleveland, OH (United States); Izquierdo-Garcia, D; Fayad, Z A, E-mail: habib.zaidi@hcuge.ch [Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York (United States)

    2011-05-21

    The Ingenuity TF PET-MRI is a newly released whole-body hybrid PET-MR imaging system with a Philips time-of-flight GEMINI TF PET and Achieva 3T X-series MRI system. Compared to PET-CT, modifications to the positron emission tomography (PET) gantry were made to avoid mutual system interference and deliver uncompromising performance which is equivalent to the standalone systems. The PET gantry was redesigned to introduce magnetic shielding for the photomultiplier tubes (PMTs). Stringent electromagnetic noise requirements of the MR system necessitated the removal of PET gantry electronics to be housed in the PET-MR equipment room. We report the standard NEMA measurements for the PET scanner. PET imaging and performance measurements were done at Geneva University Hospital as described in the NEMA Standards NU 2-2007 manual. The scatter fraction (SF) and noise equivalent count rate (NECR) measurements with the NEMA cylinder (20 cm diameter) were repeated for two larger cylinders (27 cm and 35 cm diameter), which better represent average and heavy patients. A NEMA/IEC torso phantom was used for overall assessment of image quality. The transverse and axial resolution near the center was 4.7 mm. Timing and energy resolution of the PET-MR system were measured to be 525 ps and 12%, respectively. The results were comparable to PET-CT systems demonstrating that the effect of design modifications required on the PET system to remove the harmful effect of the magnetic field on the PMTs was negligible. The absolute sensitivity of this scanner was 7.0 cps kBq{sup -1}, whereas SF was 26%. NECR measurements performed with cylinders having three different diameters, and image quality measurements performed with IEC phantom yielded excellent results. The Ingenuity TF PET-MRI represents the first commercial whole-body hybrid PET-MRI system. The performance of the PET subsystem was comparable to the GEMINI TF PET-CT system using phantom and patient studies. It is conceived that

  8. Analysis of quench-vent pressures for present design of ITER (International Thermonuclear Experimental Reactor) TF (toroidal field) coils

    Energy Technology Data Exchange (ETDEWEB)

    Slack, D.S.

    1989-09-20

    The International Thermonuclear Experimental Reactor (ITER) is a new tokamak design project with joint participation from Japan, the European Community, the Union of the Soviet Union, and the United States. This paper examines the effects of a quench within the toroidal field (TF) coils based on current ITER design. It is a preliminary, rough analysis. Its intent is to assist ITER designers while more accurate computer codes are being developed and to provide a check against these more rigorous solutions. Rigorous solutions to the quench problem are very complex involving three- dimensional heat transfer, extreme changes in heat capacities and copper resistivity, and varying flow dynamics within the conductors. This analysis addresses all these factors in an approximate way. The result is much less accurate than a rigorous analysis. Results here could be in error as much as 30 to 40 percent. However, it is believed that this paper can still be very useful to the coil designer. Coil pressures and temperatures vs time into a quench are presented. Rate of helium vent, energy deposition in the coil, and depletion of magnetic stored energy are also presented. Peak pressures are high (about 43 MPa). This is due to the very long vent path length (446 m), small hydraulic diameters, and high current densities associated with ITER's cable-in-conduit design. The effects of these pressures as well as the ability of the coil to be self protecting during a quench are discussed. 3 refs., 1 fig., 3 tabs.

  9. Design of artificial human joints & organs

    CERN Document Server

    Pal, Subrata

    2013-01-01

    This book covers the design science and methodology of artificial joints and organs.  It presents the mechanical characterization of the hard and soft tissues as well as the viscoelastic properties of the tissue.

  10. Thermo-Hydraulic Analyses Associated with the Design of JT-60SA TF Coils Development and Validation of the Tacos/texto Tool

    Science.gov (United States)

    Lacroix, B.; Portafaix, C.; Hertout, P.; Nicollet, S.; Zani, L.; Barabaschi, P.; Villari, R.

    2010-04-01

    In the framework of the JT-60SA project, TF coils design activities have led to the development of TEXTO (Thermo-hydraulic EXtended TOol), a dedicated simulation tool centred on the GANDALF code for calculating the temperature margin (ΔTma) central criterion. From a first version providing conservative results, this tool has been upgraded to a pseudo 3D model by integrating a 1D thermo-hydraulic approach in ANSYS, leading to an additional and independent module named TACOS (Thermo-hydraulic Ansys COmputation Semi 3D). By providing He temperature in conductors, TACOS is well adapted for evaluating the impact of TF coils design choices in the framework of cost and feasibility optimization. TACOS also provides more accurate values of transverse heat flux from case to conductors, which can then be injected into TEXTO and allow the calculation of the temperature margin, thanks to the functionalities of GANDALF. Several validation calculations have been performed for the reference operation scenario, by comparison with GANDALF for validating the simplified thermo-hydraulic method of TACOS and by comparison with VINCENTA for an overall validation of the TACOS/TEXTO tool. Results have shown a good consistency between the different models, with a conductor temperature dispersion around 0.05 K in the critical zone.

  11. Development of an extended thermo-hydraulic simulation tool for fusion magnet design study - Application to the initial versions of JT-60SA TF coils layout

    Science.gov (United States)

    Nicollet, S.; Lacroix, B.; Zani, L.; Hertout, P.; Portafaix, Ch.; Villari, R.

    2010-01-01

    In the framework of the EU participation to JT-60SA project [1], a dedicated simulation tool named after Thermo-hydraulic EXtended Tool (TEXTO) was developed at CEA between 2006 and 2007 in order to address in a reliable way the calculation of the magnet conductor temperature increase and temperature margins in different operating conditions. The simulation process is based on three different codes, addressing each specific aspects (MCNP for the 3D nuclear heat calculation, TRAPS for magnetic field, ANSYS for 2D transverse thermal contribution of coil casing), which finally stand as input for the well established code GANDALF (with transient helium properties). Both steady-state operating and disruption transient regimes can be studied with this process and a first application is performed on the basis of the design and operating conditions available at this time on JT-60SA TF magnets, i.e. the first version of the different design stages. The complete analysis is shown together with the associated proposals for the TF conductor layout that could be derived from these studies.

  12. FLOWTRAN-TF code description

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G.P. (ed.)

    1990-12-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  13. FLOWTRAN-TF code description

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G.P. (ed.)

    1991-09-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  14. Designing an International Joint Venture Negotiation Game.

    Science.gov (United States)

    Kenkel, Phil; And Others

    1996-01-01

    Evaluates a simulation game that models management problems encountered in negotiating and managing international joint ventures. Designed to instruct executives of state-owned agribusinesses in Indonesia in abstract concepts such as partner rapport, transfer price conflicts, and marketing disagreements, its success suggests that simulation games…

  15. New Joint Sealants. Criteria, Design and Materials.

    Science.gov (United States)

    Building Research Inst., Inc., Washington, DC.

    Contents include--(1) sealing concrete joints, (2) sealing glass and metal joints, (3) metal and glass joint sealants from a fabricator's viewpoint, (4) a theory of adhesion for joint sealants, (5) geometry of simple joint seals under strain, (6) joint sealant specifications from a manufacturer's viewpoint, (7) joint sealant requirements from an…

  16. Transferrin: evidence for two common subtypes of the TfC allele.

    Science.gov (United States)

    Kühnl, P; Spielmann, W

    1978-07-12

    Evidence is presented for an extended polymorphism of human transferrin (Tf). Three common phenotypes were observed among TfC individuals after isoelectric focusing of sera on polyacrylamide gels. They are explained in terms of two subtypes of the TfC allele, tentatively designated TfC1 and TfC2. The distribution of the phenotypes Tf C1, C2-1, and C2 provides a good fit to the Hardy-Weinberg equation. In our population sample (n = 942) the following frequencies were calculated: TfC1 = 0.8195, TfC2 = 0.1720, TfB2 = 0.0064, TfB1-2 = 0.0016, and TfD1 = 0.0005. Family studies (n = 112) indicate an autosomal codominant way of inheritance. The observed subheterogeneity is detectable in purified transferrin after isofocusing and subsequent immunofixation. The subtypes are still present after treatment of sera with neuraminidase.

  17. Systemic Operational Design: Enhancing the Joint Operation Planning Process

    National Research Council Canada - National Science Library

    Delacruz, Victor J

    2007-01-01

    Operational level commanders and their staffs require relevant and current joint doctrine that articulates the critical function of operational design and its role in the Joint Operation Planning Process (JOPP...

  18. Simplifying Bridge Expansion Joint Design and Maintenance

    Science.gov (United States)

    2011-10-19

    This report presents a study focused on identifying the most durable expansion joints for the South : Carolina Department of Transportation. This is performed by proposing a degradation model for the : expansion joints and updating it based on bridge...

  19. A simple design rule for overlap joints

    NARCIS (Netherlands)

    Straalen, IJ.J. van

    2004-01-01

    For toughened and flexible adhesives it is found that a simple prediction model for overlap joints can be used to calculate the ultimate strength for the static load case. The absolute maximum strength for a lap joint is when the whole of the adhesive layer is at the shear yield strength. An

  20. Structural elements and joints - a generator for design explorations

    DEFF Research Database (Denmark)

    Christensen, Jesper Thøger; Damkilde, Lars

    2017-01-01

    throughout the early design process. Thus, the methodology conceives design as a combination of a top-down and a bottom-up approach. Furthermore, the paper suggests forms of representation to investigate the different scales and ensure that joint, structure and architecture inform each other. Results from......The paper introduces a methodology for structural elements and joints to become a generator for design explorations in the early conceptual design of buildings. To make the design team think about structure and joints, the authors propose to look at design from both the small and the big scale...... using this methodology are exemplified using a group of students in architectural engineering. In the process of designing a proposal for a temporary pavilion in timber, they learnt how design of joints influences structural strength and architectural expression. Implementation of the methodology may...

  1. Improved bridge joint materials and design details.

    Science.gov (United States)

    2017-06-01

    Expansion joints accommodate bridge movements that result from factors such as thermal expansion and contraction, concrete shrinkage, creep effects, live loading, settlement of the foundation and substructure, and environmental stressors. Expansion j...

  2. FLOWTRAN-TF code description. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G.P. [ed.

    1991-09-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  3. Determination of representative dimension parameter values of Korean knee joints for knee joint implant design.

    Science.gov (United States)

    Kwak, Dai Soon; Tao, Quang Bang; Todo, Mitsugu; Jeon, Insu

    2012-05-01

    Knee joint implants developed by western companies have been imported to Korea and used for Korean patients. However, many clinical problems occur in knee joints of Korean patients after total knee joint replacement owing to the geometric mismatch between the western implants and Korean knee joint structures. To solve these problems, a method to determine the representative dimension parameter values of Korean knee joints is introduced to aid in the design of knee joint implants appropriate for Korean patients. Measurements of the dimension parameters of 88 male Korean knee joint subjects were carried out. The distribution of the subjects versus each measured parameter value was investigated. The measured dimension parameter values of each parameter were grouped by suitable intervals called the "size group," and average values of the size groups were calculated. The knee joint subjects were grouped as the "patient group" based on "size group numbers" of each parameter. From the iterative calculations to decrease the errors between the average dimension parameter values of each "patient group" and the dimension parameter values of the subjects, the average dimension parameter values that give less than the error criterion were determined to be the representative dimension parameter values for designing knee joint implants for Korean patients.

  4. Principles of human joint replacement design and clinical application

    CERN Document Server

    Buechel, Frederick F

    2015-01-01

    This book is written for the users and designers of joint replacements. In its second extended edition it conveys to the reader the knowledge accumulated by the authors during their forty year effort on the development of replacement devices for the lower limb for the purpose of aiding the reader in their design and evaluation of joint replacement devices. The early chapters describe the engineering, scientific and medical principles needed for replacement joint evaluation. One must understand the nature and performance of the materials involved and their characteristics in vivo, i.e. the response of the body to implant materials. It is also essential to understand the response of the implants to applied loading and motion, particularly in the hostile physiological environment. A chapter describes the design methodology now required for joint replacement in the USA and EU countries. The remaining chapters provide a history of joint replacement, an evaluation of earlier and current devices and sample case hist...

  5. Design, Static Analysis And Fabrication Of Composite Joints

    Science.gov (United States)

    Mathiselvan, G.; Gobinath, R.; Yuvaraja, S.; Raja, T.

    2017-05-01

    The Bonded joints will be having one of the important issues in the composite technology is the repairing of aging in aircraft applications. In these applications and also for joining various composite material parts together, the composite materials fastened together either using adhesives or mechanical fasteners. In this paper, we have carried out design, static analysis of 3-D models and fabrication of the composite joints (bonded, riveted and hybrid). The 3-D model of the composite structure will be fabricated by using the materials such as epoxy resin, glass fibre material and aluminium rivet for preparing the joints. The static analysis was carried out with different joint by using ANSYS software. After fabrication, parametric study was also conducted to compare the performance of the hybrid joint with varying adherent width, adhesive thickness and overlap length. Different joint and its materials tensile test result have compared.

  6. Application of Bionic Design to FRP T-Joints

    Science.gov (United States)

    Luo, Guang-Min; Kuo, Chia-Hung

    2017-09-01

    We applied the concepts of bionics to enhance the mechanical strength of fiberglass reinforced plastic T-joints. The failure modes of the designed arthrosis-like and gum-like joints were determined using three-point bending tests and numerical simulations and compared with those of normal T-joints bonded using structural adhesives. In the simulation, we used cohesive elements to simulate the adhesive interface of the structural adhesive. The experimental and simulation results show that the arthrosis-like joint can effectively delay the failure progress and enhance the bonding strength of T-joints, thus confirming that an appropriate bionic design can effectively control the bonding properties of structural adhesives.

  7. Principles of Human Joint Replacement Design and Clinical Application

    CERN Document Server

    Buechel, Frederick F

    2012-01-01

    Drs. Buechel, an orthopaedic surgeon, and Pappas, a professor of Mechanical Engineering, are the designers of several successful joint replacement systems. The most well-known of these is the pioneering LCS knee replacement. They have written this book for the users and designers of joint replacements. It is an attempt to convey to the reader the knowledge accumulated by the authors during their thirty five year effort on the development of replacement devices for the lower limb for the purpose of aiding the reader in their design and evaluation of joint replacement devices. The early chapters describe the engineering, scientific and medical principles needed for replacement joint evaluation. One must understand the nature and performance of the materials involved and their characteristics in vivo, i.e. the response of the body to implant materials. It is also essential to understand the response of the implants to applied loading and motion, particularly in the hostile physiological environment. A chapter de...

  8. Riveted Lap Joints in Aircraft Fuselage Design, Analysis and Properties

    CERN Document Server

    Skorupa, Andrzej

    2012-01-01

    Fatigue of the pressurized fuselages of transport aircraft is a significant problem all builders and users of aircraft have to cope with for reasons associated with assuring a sufficient lifetime and safety, and formulating adequate inspection procedures. These aspects are all addressed in various formal protocols for creating and maintaining airworthiness, including damage tolerance considerations. In most transport aircraft, fatigue occurs in lap joints, sometimes leading to circumstances that threaten safety in critical ways. The problem of fatigue of lap joints has been considerably enlarged by the goal of extending aircraft lifetimes. Fatigue of riveted lap joints between aluminium alloy sheets, typical of the pressurized aircraft fuselage, is the major topic of the present book. The richly illustrated and well-structured chapters treat subjects such as: structural design solutions and loading conditions for fuselage skin joints; relevance of laboratory test results for simple lap joint specimens to rive...

  9. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.

    Science.gov (United States)

    Bien-Ly, Nga; Yu, Y Joy; Bumbaca, Daniela; Elstrott, Justin; Boswell, C Andrew; Zhang, Yin; Luk, Wilman; Lu, Yanmei; Dennis, Mark S; Weimer, Robby M; Chung, Inhee; Watts, Ryan J

    2014-02-10

    Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and β-secretase (BACE1 [β-amyloid cleaving enzyme-1]) traverse the blood-brain barrier (BBB) and effectively reduce brain amyloid β levels. We found that optimizing anti-TfR affinity improves brain exposure and BACE1 inhibition. Here we probe the cellular basis of this improvement and explore whether TfR antibody affinity alters the intracellular trafficking of TfR. Comparing high- and low-affinity TfR bispecific antibodies in vivo, we found that high-affinity binding to TfR caused a dose-dependent reduction of brain TfR levels. In vitro live imaging and colocalization experiments revealed that high-affinity TfR bispecific antibodies facilitated the trafficking of TfR to lysosomes and thus induced the degradation of TfR, an observation which was further confirmed in vivo. Importantly, high-affinity anti-TfR dosing induced reductions in brain TfR levels, which significantly decreased brain exposure to a second dose of low-affinity anti-TfR bispecific. Thus, high-affinity anti-TfR alters TfR trafficking, which dramatically impacts the capacity for TfR to mediate BBB transcytosis.

  10. Joint design of QC-LDPC codes for coded cooperation system with joint iterative decoding

    Science.gov (United States)

    Zhang, Shunwai; Yang, Fengfan; Tang, Lei; Ejaz, Saqib; Luo, Lin; Maharaj, B. T.

    2016-03-01

    In this paper, we investigate joint design of quasi-cyclic low-density-parity-check (QC-LDPC) codes for coded cooperation system with joint iterative decoding in the destination. First, QC-LDPC codes based on the base matrix and exponent matrix are introduced, and then we describe two types of girth-4 cycles in QC-LDPC codes employed by the source and relay. In the equivalent parity-check matrix corresponding to the jointly designed QC-LDPC codes employed by the source and relay, all girth-4 cycles including both type I and type II are cancelled. Theoretical analysis and numerical simulations show that the jointly designed QC-LDPC coded cooperation well combines cooperation gain and channel coding gain, and outperforms the coded non-cooperation under the same conditions. Furthermore, the bit error rate performance of the coded cooperation employing jointly designed QC-LDPC codes is better than those of random LDPC codes and separately designed QC-LDPC codes over AWGN channels.

  11. Validation of welding technology for ITER TF coil structures

    Energy Technology Data Exchange (ETDEWEB)

    Chida, Yutaka, E-mail: chida.yutaka@jaea.go.jp [Japan Atomic Energy Agency (Japan); Iguchi, Masahide; Takano, Katutoshi; Nakajima, Hideo [Japan Atomic Energy Agency (Japan); Oosemochi, Koichi [Toshiba Corporation (Japan); Niimi, Kenichiro; Tokai, Daisuke [Kawasaki Heavy Industries, LTD. (Japan); Gallix, Remy [ITER Organization (France)

    2011-12-15

    Japan Atomic Energy Agency (JAEA), acting as the Japan Domestic Agency (JADA) in the ITER project is responsible for the procurement of 9 Toroidal Field (TF) coil winding packs (WPs), structures for 19 TF coils (including one spare), and assembly of the WPs and the coil structures for 9 TF coils . The TF Coil structures which support large electromagnetic force generated in TF coils under the cryogenic temperature (about 4 K), are very large welded structures composed of a coil case and structural attachments made of high strength and high toughness stainless steel. JAEA has been performing welding trials for heavy thickness materials since 2008 and is planning fabrication of full-scale mock-ups of main sub-components (1 set for the inboard side and 1 set for the outboard side) in 2011 in order to investigate the technical issues for manufacturing the TF coil structures. This paper presents the results of welding trials and the status of full scale mock-ups fabrication to confirm the validity of welding technology and manufacturing design before fabricating the actual products.

  12. Development of Design Rules for Adhesive Bonded Joints

    NARCIS (Netherlands)

    Van Straalen, I.J.; Van Tooren, M.J.L.

    2002-01-01

    This article deals with the development of design rules for structural adhesive bonded joints. In daily practice engineers are confronted with the problem to verify the reliability of their designs. This can be done with use of an experimental programme, but for the marine, transport, building and

  13. Development of design rules for adhesive bonded joints

    NARCIS (Netherlands)

    Straalen, IJ.J. van; Tooren, M.J.L. van

    2002-01-01

    This article deals with the development of design rules for structural adhesive bonded joints. In daily practice engineers are confronted with the problem to verify the reliability of their designs. This can be done with use of an experimental programme, but for the marine, transport, building and

  14. A Mastication Mechanism Designed for Testing Temporomandibular Joint Implants

    Directory of Open Access Journals (Sweden)

    Ryan J. Frayne

    2012-01-01

    Full Text Available The development of temporomandibular joint implants has involved simplified mechanical tests that apply pure vertical forces or pure rotational movements to the implant. The aim of this study was to develop a biological based mastication mechanism and conduct preliminary testing of a novel temporomandibular joint implant. The mechanism was designed to mimic temporomandibular joint loads by performing compression and anterior/posterior translation. Pilot testing was performed on six implant/joint specimens for seven consecutive hours, completing approximately 22,000 cycles at a frequency of approximately 1 Hz. Each cycle had a joint compression phase (67.3 N over 0.15 s followed by a translation phase (8.67 N over 0.43 s that was similar to joint loads/motions that have been reported in vivo. This new mastication mechanism incorporates both anatomical and mechanical variability. The use of biological specimens is an important approach that can help bridge the gap between traditional synthetic implant materials/mechanical testing and in vivo testing.

  15. Design and wear testing of a temporomandibular joint prosthesis articulation

    NARCIS (Netherlands)

    van Loon, JP; Verkerke, GJ; de Vries, MP; de Bont, LGM

    As part of the development of a total temporomandibular joint prosthesis, a prosthesis articulation was designed. The articulation consists of a spherical head (ball) of the mandibular part, rotating against an enveloping ultra-high-molecular-weight polyethylene (UHMWPE) disc with a flat cranial

  16. Joint Curriculum Developments in the Field of Virtual Space Design

    DEFF Research Database (Denmark)

    Mullins, Michael; Zupancic, Tadeja; Juvancic, Matevz

    2006-01-01

    initiates a discussion-forum to raise and discuss open questions of joint curriculum development in the field of virtual space design, especially where CVE-s take the key role within the educational process. The starting points of the discussion can be found in the ongoing endeavours of the e......-Learning project entitled VIPA and the current curricular changes in the ‘new’ EU countries following relevant directives and declarations. The main goal of this forum is the development of the specific criteria for quality assurance, to enhance the motivation of joint curricular developments in the field...

  17. A coil test facility for the cryogenic tests of the JT-60SA TF coils

    Energy Technology Data Exchange (ETDEWEB)

    Chantant, M., E-mail: michel.chantant@cea.fr [CEA/DSM/IRFM, F-13108 Saint Paul-lez-Durance (France); Genini, L. [CEA/DSM/Irfu CEA-Saclay, F-91191 Gif-sur-Yvette Cedex (France); Bayetti, P. [CEA/DSM/IRFM, F-13108 Saint Paul-lez-Durance (France); Millet, F. [CEA/DSM/INAC, F-38054 Grenoble Cedex (France); Wanner, M. [F4E, Broader Fusion Development Department Boltzmannstr.2, D-85748 Garching (Germany); Massaut, V. [SCK/CEN Boeretang 200 2400 Mol (Belgium); Corte, A. Della [ENEA CRE Frascati Via Enrico Fermi 45 CP65 00044 frascati Italy (Italy); Ardelier-Desage, F. [CEA/DSM/Irfu CEA-Saclay, F-91191 Gif-sur-Yvette Cedex (France); Catherine-Dumont, V. [CEA/DSM/IRFM, F-13108 Saint Paul-lez-Durance (France); Dael, A. [CEA/DSM/Irfu CEA-Saclay, F-91191 Gif-sur-Yvette Cedex (France); Decool, P. [CEA/DSM/IRFM, F-13108 Saint Paul-lez-Durance (France); Donati, A. [CEA/DSM/Irfu CEA-Saclay, F-91191 Gif-sur-Yvette Cedex (France); Duchateau, J.L.; Garibaldi, P.; Girard, S.; Hatchressian, J.C.; Fejoz, P. [CEA/DSM/IRFM, F-13108 Saint Paul-lez-Durance (France); Jamotton, P. [CSL-LIEGE Science Park, Avenue du Pre-Aily, 4031 Angleur (Belgium); Jourdheuil, L. [CEA/DSM/IRFM, F-13108 Saint Paul-lez-Durance (France); Juster, F.P. [CEA/DSM/Irfu CEA-Saclay, F-91191 Gif-sur-Yvette Cedex (France)

    2011-10-15

    In the framework of the Broader Approach Activities, the EU will deliver to Japan the 18 superconducting coils, which constitute the JT-60SA Toroidal field magnet. These 18 coils, manufactured by France and Italy, will be cold tested before shipping to Japan. For this purpose, the European Joint Undertaking for ITER, the Development of Fusion Energy ('Fusion for Energy', F4E) and the European Voluntary Contributors are collaborating to design and set-up a coil test facility (CTF) and to perform the acceptance test of the 18 JT-60SA Toroidal Field (TF) coils. The test facility is designed to test one coil at a time at nominal current and cryogenic temperature. The test of the first coil of each manufacturer includes a quench triggered by increasing the temperature. The project is presently in the detailed design phase.

  18. 2014 Joint Conference on Mechanical Design Engineering and Advanced Manufacturing

    CERN Document Server

    Daidie, Alain; Eynard, Benoit; Paredes, Manuel

    2016-01-01

    Covering key topics in the field such as technological innovation, human-centered sustainable engineering and manufacturing, and manufacture at a global scale in a virtual world, this book addresses both advanced techniques and industrial applications of key research in interactive design and manufacturing. Featuring the full papers presented at the 2014 Joint Conference on Mechanical Design Engineering and Advanced Manufacturing, which took place in June 2014 in Toulouse, France, it presents recent research and industrial success stories related to implementing interactive design and manufacturing solutions.

  19. Ku Band Rotary Joint Design for SNG Vehicles

    Directory of Open Access Journals (Sweden)

    H. Torpi

    2015-12-01

    Full Text Available A wideband I-type rectangular waveguide rotary joint (RJ is designed, simulated and built. It has an excellent performance over the whole Ku Band (10.7-14.5 GHz where the return loss is less than -23 dB at its highest and the insertion loss is below 0.4 dB. The rotary joint is specifically designed for satellite news gathering (SNG vehicles providing elevation and azimuthal movement to the antenna and matching polarization when it is needed at the feed. It can also be used in other high power microwave applications,where rotation ability of the antenna is a must during the transmission such as radars.

  20. International Joint Conference on Mechanics, Design Engineering & Advanced Manufacturing

    CERN Document Server

    Nigrelli, Vincenzo; Oliveri, Salvatore; Peris-Fajarnes, Guillermo; Rizzuti, Sergio

    2017-01-01

    This book gathers papers presented at the International Joint Conference on Mechanics, Design Engineering and Advanced Manufacturing (JCM 2016), held on 14-16 September, 2016, in Catania, Italy. It reports on cutting-edge topics in product design and manufacturing, such as industrial methods for integrated product and process design; innovative design; and computer-aided design. Further topics covered include virtual simulation and reverse engineering; additive manufacturing; product manufacturing; engineering methods in medicine and education; representation techniques; and nautical, aeronautics and aerospace design and modeling. The book is divided into eight main sections, reflecting the focus and primary themes of the conference. The contributions presented here will not only provide researchers, engineers and experts in a range of industrial engineering subfields with extensive information to support their daily work; they are also intended to stimulate new research directions, advanced applications of t...

  1. Coactive Design : Designing Support for Interdependence in Joint Activity

    NARCIS (Netherlands)

    Johnson, M.; Bradshaw, J.M.; Feltovich, P.J.; Jonker, C.M.; Van Riemsdijk, M.B.; Sierhuis, M.

    2014-01-01

    Coactive Design is a new approach to address the increasingly sophisticated roles that people and robots play as the use of robots expands into new, complex domains. The approach is motivated by the desire for robots to perform less like teleoperated tools or independent automatons and more like

  2. Designing prosthetic knee joints with bio-inspired bearing surfaces.

    Science.gov (United States)

    Qiu, Mingfeng; Chyr, Anthony; Sanders, Anthony P; Raeymaekers, Bart

    2014-09-01

    It has long been known that articular cartilage exhibits a surface microtexture with shallow indentations. By contrast, prosthetic joints consist of ultra-smooth bearing surfaces, the longevity of which does not reach that of natural cartilage. We show that adding a microtexture to the smooth femoral component of a prosthetic knee joint reduces friction by increasing the lubricant film thickness between the bearing surfaces of the knee. We have implemented an elastohydrodynamic lubrication model to optimize the geometry of the microtexture, while taking into account the deformation of the polyethylene tibial insert. We have manufactured several microtexture designs on a surrogate femoral component, and experimentally demonstrate that the microtexture reduces friction between the surrogate femoral component and tibial insert.

  3. Corrosion Issues in Solder Joint Design and Service

    Energy Technology Data Exchange (ETDEWEB)

    VIANCO,PAUL T.

    1999-11-24

    Corrosion is an important consideration in the design of a solder joint. It must be addressed with respect to the service environment or, as in the case of soldered conduit, as the nature of the medium being transported within piping or tubing. Galvanic-assisted corrosion is of particular concern, given the fact that solder joints are comprised of different metals or alloy compositions that are in contact with one-another. The (thermodynamic) potential for corrosion to take place in a particular environment requires the availability of the galvanic series for those conditions and which includes the metals or alloys in question. However, the corrosion kinetics, which actually determine the rate of material loss under the specified service conditions, are only available through laboratory evaluations or field data that are found in the existing literature or must be obtained by in-house testing.

  4. Virtual Welded - Joint Design Integrating Advanced Materials and Processing Technology

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zhishang; Ludewig, Howard W.; Babu, S. Suresh

    2005-06-30

    Virtual Welede-Joint Design, a systematic modeling approach, has been developed in this project to predict the relationship of welding process, microstructure, properties, residual stress, and the ultimate weld fatique strength. This systematic modeling approach was applied in the welding of high strength steel. A special welding wire was developed in this project to introduce compressive residual stress at weld toe. The results from both modeling and experiments demonstrated that more than 10x fatique life improvement can be acheived in high strength steel welds by the combination of compressive residual stress from the special welding wire and the desired weld bead shape from a unique welding process. The results indicate a technology breakthrough in the design of lightweight and high fatique performance welded structures using high strength steels.

  5. CEA studies and qualifications prior to the JT-60SA TF coils manufacture

    Energy Technology Data Exchange (ETDEWEB)

    Decool, P., E-mail: patrick.decool@cea.fr; Cloez, H.; Gros, G.; Jiolat, G.; Maréchal, J.L.; Torre, A.; Verger, J.M.

    2013-10-15

    Following the first conceptual design activity in which the general design of the JT-60SA TF system was defined in agreement with all the participants in the project (CEA, ENEA, F4E), a second phase dealing with the detailed design was engaged by each of the voluntary contributors. For the French part which includes the procurement of 9 of the TF winding packs and their integration in the casing, an industrial contract was signed mid 2011 with Alstom (France). Several actions have been carried out to prepare the manufacturing phase. To precisely define one of the main interfaces which is the temporary electrical connection of the coils to the current leads during cold test in the CEA facility as well as their final connection to the feeders at the Naka site, a design compatible with both requirements was developed by CEA, supported by the previous developments led on the joints and assembly techniques. In addition to prepare the coils manufacture, hydraulic qualification was led on the first conductor qualification length to set the parameters which will be used by the coils manufacturer for conductor acceptance. At last, mechanical characterizations of both the conductor and of the empty compacted jacket were performed in order to define as precisely as possible the elastic and plastic properties of these components. These are crucial properties used during the bending process which is one of the most important operations during the winding pack manufacture. These data will be very helpful for the winding machine parameters settings as well as for designing the local bending tooling needed to shape the conductors extremities at the connection area and at the double pancakes joggles.

  6. Design of joints in steel and composite structures Eurocode 3 : design of steel structures : part 1-8 : design of joints, Eurocode 4 : design of composite steel and concrete structures : part 1-1 : general rules and rules for buildings

    CERN Document Server

    Jaspart, Jean-Pierre

    2016-01-01

    This book details the basic concepts and the design rules included in Eurocode 3 Design of steel structures Part 1-8 Design of joints. Joints in composite construction are also addressed through references to Eurocode 4 Design of composite steel and concrete structures Part 1-1 General rules and rules for buildings. Attention has to be duly paid to the joints when designing a steel or composite structure, in terms of the global safety of the construction, and also in terms of the overall cost, including fabrication, transportation and erection. Therefore, in this book, the design of the joints themselves is widely detailed, and aspects of selection of joint configuration and integration of the joints into the analysis and the design process of the whole construction are also fully covered. Connections using mechanical fasteners, welded connections, simple joints, moment-resisting joints and lattice girder joints are considered. Various joint configurations are treated, including beam-to-column, beam-to-beam, ...

  7. TfR Binding Peptide Screened by Phage Display Technology ...

    African Journals Online (AJOL)

    gain entry via the endocytic pathway. Conclusion: BP9 can bind to TfR and inhibit the proliferation of the tumour cells over-expressing TfR. The DNA sequence coding for BP9 was able to target the macromolecule to combine with TfR. BP9 may possess potential applications in cancer therapy. Keywords: Peptide, hTfR ...

  8. Design and Performance Analysis of a new Rotary Hydraulic Joint

    Science.gov (United States)

    Feng, Yong; Yang, Junhong; Shang, Jianzhong; Wang, Zhuo; Fang, Delei

    2017-07-01

    To improve the driving torque of the robots joint, a wobble plate hydraulic joint is proposed, and the structure and working principle are described. Then mathematical models of kinematics and dynamics was established. On the basis of this, dynamic simulation and characteristic analysis are carried out. Results show that the motion curve of the joint is continuous and the impact is small. Moreover the output torque of the joint characterized by simple structure and easy processing is large and can be rotated continuously.

  9. Quantitative Methods for Analysing Joint Questionnaire Data: Exploring the Role of Joint in Force Design

    Science.gov (United States)

    2015-08-01

    Kernot and Tim McKay Joint and Operations Analysis Division Defence Science and Technology Organisation DST-Group-TN-1474 ABSTRACT In...dimensional space comprising: Coordination and Organisation ; Social Capital; and Optimisation of the Socio-technical Systems. Given the variability of the...UNCLASSIFIED Published by Joint and Operations Analysis Division DSTO Defence Science and Technology Organisation 506 Lorimer St Fishermans Bend

  10. A Cross-Cultural and Interdisciplinary Collaboration in a Joint Design Studio

    Science.gov (United States)

    Kim, Mi Jeong; Ju, Seo Ryeung; Lee, Lina

    2015-01-01

    A design studio is a critical venue for design students, as they are educated to develop design thinking and other skills through studio courses. This article introduces a design studio project in which Korean and Malaysian students worked jointly for one semester to design affordable urban housing. The Korean students were interior design majors…

  11. Influence of implant/abutment joint designs on abutment screw loosening in a dental implant system.

    Science.gov (United States)

    Kitagawa, Tsuyoshi; Tanimoto, Yasuhiro; Odaki, Misako; Nemoto, Kimiya; Aida, Masahiro

    2005-11-01

    The objective of this study was to investigate the influence of implant/abutment joint designs on abutment screw loosening in a dental implant system, using nonlinear dynamic analysis of the finite element method (FEM). This finite element simulation study used two dental implant systems: the Ankylos implant system (Degusa Dental, Hanau, German) with a taper joint (taper joint-type model), and the Bränemark implant system (Nobel Biocare, Gothenburg, Sweden) with an external hex joint (external hex joint-type model). The nonlinear dynamic analysis was performed using three-dimensional finite element analysis. In comparing the movement of the taper type-joint model and external hex type-joint model, it was found that the external hex type-joint model had greater movement than the taper type-joint model. The external hex joint-type model showed rotation movement, whereas the movement of the taper joint-type model showed no rotation. It was concluded that the nonlinear dynamic analysis used in this study clearly demonstrated the differences in rotation of components in dental implant systems with taper or external hex joints. Copyright (c) 2005 Wiley Periodicals, Inc.

  12. Jointly Optimal Design for MIMO Radar Frequency-Hopping Waveforms Using Game Theory

    Science.gov (United States)

    2016-04-01

    Jointly Optimal Design for MIMO Radar Frequency-Hopping Waveforms Using Game Theory KEYONG HAN, Student Member, IEEE ARYE NEHORAI, Fellow, IEEE...matrices that result in improved performance over that of separate designs. We propose a game theory framework for the joint design. First, we present...badly when the function evaluation is expensive. In recent years, game theory has been used to solve multiobjective design problems, especially for

  13. Design and test of lightweight sandwich T-joint for naval ships

    DEFF Research Database (Denmark)

    Toftegaard, H.; Lystrup, Aa.

    2005-01-01

    -joint with reduced weight but with the same or higher strength than the existing design. The lightweight T-joint is designed for sandwich panels with 60 mm thick PVC foam core and 4 rum thick glass fibre/vinyl ester skin laminates. The panels are joined by use of filler and two triangular PVC foam fillets (core...... of panels joined by filler and overlaminates of the same thickness as the skin laminates. Various improved T-joints have been designed and investigated. Some with focus on improved strength (survivability), and others with focus on reduced weight. This paper describes the design and test of a sandwich T...

  14. Advances in the analysis and design of adhesive-bonded joints in composite aerospace structures

    Science.gov (United States)

    Hart-Smith, L. J.

    1974-01-01

    Several aspects of adhesive-bonded joint analysis and design are presented from the reference of size of structure or load intensity. This integrates the individual characterizations of double-lap, single-lap, stepped-lap, tapered-lap and scarf joints. The paper includes an overview of bonded joint selection from the standpoints of design, fabrication, and processing, each bearing in mind the influence of such considerations on the strength of the joint. A case study is presented of the optimization of a specific relatively thick titanium-to-graphite epoxy stepped-lap joint, using the digital computer analysis program A4EG. The factors accounted for are adhesive plasticity, adherend stiffness imbalance, adherend thermal mismatch, and change of material properties within the range of temperature environment and with load direction. The strength increases obtainable by refining the initial design are demonstrated.

  15. Knee Joint Optimization Design of Intelligent Bionic Leg Based on Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Hualong Xie

    2014-09-01

    Full Text Available Intelligent bionic leg (IBL is an advanced prosthesis which can maximum functionally simulate and approach the motion trajectory of human leg. Knee joint is the most important bone of human leg and its bionic design has great significance to prosthesis performance. The structural components of IBL are introduced and virtual prototype is given. The advantages of 4-bar knee joint are analyzed and are adopted in IBL design. The kinematics model of 4-bar knee joint is established. The objective function, constraint condition, parameters selection and setting of genetic algorithm are discussed in detail. Based on genetic algorithm, the optimization design of IBL knee joint is done. The optimization results indicate that the 4-bar mechanism can achieve better anthropomorphic characteristics of human knee joint.

  16. Seal Joint Analysis and Design for the Ares-I Upper Stage LOX Tank

    Science.gov (United States)

    Phillips, Dawn R.; Wingate, Robert J.

    2011-01-01

    The sealing capability of the Ares-I Upper Stage liquid oxygen tank-to-sump joint is assessed by analyzing the deflections of the joint components. Analyses are performed using three-dimensional symmetric wedge finite element models and the ABAQUS commercial finite element software. For the pressure loads and feedline interface loads, the analyses employ a mixed factor of safety approach to comply with the Constellation Program factor of safety requirements. Naflex pressure-assisted seals are considered first because they have been used successfully in similar seal joints in the Space Shuttle External Tank. For the baseline sump seal joint configuration with a Naflex seal, the predicted joint opening greatly exceeds the seal design specification. Three redesign options of the joint that maintain the use of a Naflex seal are studied. The joint openings for the redesigned seal joints show improvement over the baseline configuration; however, these joint openings still exceed the seal design specification. RACO pressure-assisted seals are considered next because they are known to also be used on the Space Shuttle External Tank, and the joint opening allowable is much larger than the specification for the Naflex seals. The finite element models for the RACO seal analyses are created by modifying the models that were used for the Naflex seal analyses. The analyses show that the RACO seal may provide sufficient sealing capability for the sump seal joint. The results provide reasonable data to recommend the design change and plan a testing program to determine the capability of RACO seals in the Ares-I Upper Stage liquid oxygen tank sump seal joint.

  17. Inferring condition-specific targets of human TF-TF complexes using ChIP-seq data.

    Science.gov (United States)

    Yang, Chia-Chun; Chen, Min-Hsuan; Lin, Sheng-Yi; Andrews, Erik H; Cheng, Chao; Liu, Chun-Chi; Chen, Jeremy J W

    2017-01-10

    Transcription factors (TFs) often interact with one another to form TF complexes that bind DNA and regulate gene expression. Many databases are created to describe known TF complexes identified by either mammalian two-hybrid experiments or data mining. Lately, a wealth of ChIP-seq data on human TFs under different experiment conditions are available, making it possible to investigate condition-specific (cell type and/or physiologic state) TF complexes and their target genes. Here, we developed a systematic pipeline to infer Condition-Specific Targets of human TF-TF complexes (called the CST pipeline) by integrating ChIP-seq data and TF motifs. In total, we predicted 2,392 TF complexes and 13,504 high-confidence or 127,994 low-confidence regulatory interactions amongst TF complexes and their target genes. We validated our predictions by (i) comparing predicted TF complexes to external TF complex databases, (ii) validating selected target genes of TF complexes using ChIP-qPCR and RT-PCR experiments, and (iii) analysing target genes of select TF complexes using gene ontology enrichment to demonstrate the accuracy of our work. Finally, the predicted results above were integrated and employed to construct a CST database. We built up a methodology to construct the CST database, which contributes to the analysis of transcriptional regulation and the identification of novel TF-TF complex formation in a certain condition. This database also allows users to visualize condition-specific TF regulatory networks through a user-friendly web interface.

  18. Capturing and Reuse of Design Knowledge during the Conceptual Design Process: Illustrated with a Snap-Fit Joint

    DEFF Research Database (Denmark)

    Jensen, Thomas Aakjær; Hansen, Claus Thorp

    1998-01-01

    In this paper a concept for a computer based system, a Designer’s Workbench (DWB), is presented, for supporting a designer during the conceptual design process. The DWB is based on design units, which are a clustering of design knowledge related to the conceptual design phase. It is shown, how th...... these design units can be created by the designer during the conceptual design process, and later reused in another design project. The design of a snap-fit joint, is used to illustrated this approach to design....

  19. A personalized 3D-printed prosthetic joint replacement for the human temporomandibular joint: From implant design to implantation.

    Science.gov (United States)

    Ackland, David C; Robinson, Dale; Redhead, Michael; Lee, Peter Vee Sin; Moskaljuk, Adrian; Dimitroulis, George

    2017-05-01

    Personalized prosthetic joint replacements have important applications in cases of complex bone and joint conditions where the shape and size of off-the-shelf components may not be adequate. The objective of this study was to design, test and fabricate a personalized 3D-printed prosthesis for a patient requiring total joint replacement surgery of the temporomandibular joint (TMJ). The new 'Melbourne' prosthetic TMJ design featured a condylar component sized specifically to the patient and fixation screw positions that avoid potential intra-operative damage to the mandibular nerve. The Melbourne prosthetic TMJ was developed for a 58-year-old female recipient with end-stage osteoarthritis of the TMJ. The load response of the prosthesis during chewing and a maximum-force bite was quantified using a personalized musculoskeletal model of the patient's masticatory system developed using medical images. The simulations were then repeated after implantation of the Biomet Microfixation prosthetic TMJ, an established stock device. The maximum condylar stresses, screw stress and mandibular stress at the screw-bone interface were lower in the Melbourne prosthetic TMJ (259.6MPa, 312.9MPa and 198.4MPa, respectively) than those in the Biomet Microfixation device (284.0MPa, 416.0MPa and 262.2MPa, respectively) during the maximum-force bite, with similar trends also observed during the chewing bite. After trialing surgical placement and evaluating prosthetic TMJ stability using cadaveric specimens, the prosthesis was fabricated using 3D printing, sterilized, and implanted into the female recipient. Six months post-operatively, the prosthesis recipient had a normal jaw opening distance (40.0 mm), with no complications identified. The new design features and immediate load response of the Melbourne prosthetic TMJ suggests that it may provide improved clinical and biomechanical joint function compared to a commonly used stock device, and reduce risk of intra-operative nerve damage

  20. Designing aluminium friction stir welded joints against multiaxial fatigue

    Directory of Open Access Journals (Sweden)

    L. Susmel

    2016-07-01

    Full Text Available The present paper investigates the accuracy of the Modified Wöhler Curve Method (MWCM in estimating multiaxial fatigue strength of aluminium friction stir (FS welded joints. Having developed a bespoke joining technology, circumferentially FS welded tubular specimens of Al 6082-T6 were tested under proportional and non-proportional tension and torsion, the effect of non-zero mean stresses being also investigated. The validation exercise carried out using the experimental results have demonstrated that the MWCM applied in terms of nominal stresses, notch stresses, and also the Point Method is accurate in predicting the fatigue lifetime of the tested FS welded joints, with its use resulting in life estimates that fall within the uniaxial and torsional calibration scatter bands.

  1. Designing and Managing Successful International Joint Development Programs

    Science.gov (United States)

    2016-04-30

    joint development programs are important because of their potential to reduce costs and increase partnership benefits such as interoperability, economies ...affordability. There is a tradeoff between achieving leading-edge technology and affordability structures, specifically economies of scale... Economies of scale exist when the scale of output increases to a point where the average per-unit costs of production begins to decrease. The exceptionally

  2. Hard Upper Torso Shoulder Joint Design for Crew Member Sizing Adjustment and Enhanced Mobility Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Air-Lock, Incorporated proposes to design an Enhanced Shoulder Mobility Joint Assembly (ESMJA) that increases dynamic mobility and static sizing capabilities for...

  3. Design and Testing of Low Cost Chair with Round Mortise and Tenon Joints

    Directory of Open Access Journals (Sweden)

    Jaroslav Začal

    2016-01-01

    Full Text Available The present paper focuses on construction of school seats for developing countries from locally available resources using the local industry and low-end technology. Aim of the work is experimental assessment of mechanical properties of joints flexion in angular plane. Furthermore work considers assessment of joint firmness and comparison between various joint types. Paper encloses the review of various joint manufacturing designs (tenon and mortise, which were proposed for its suitable mechanical properties and simplicity of manufacturing. Designated joint type is easiest form of joint construction and technologically feasible for chair manufacturing. The joints were constructed from fir wood. Further the work introduces design of simple seat construction made from massive wood material manufactured by low-end technology with regards to achieving the due specifications. The task of this work is to design the viable manufacturing process of seats and chairs from raw wood and scrap material. Essential part of work is also manufacturing of seat prototype and simplified model of proposed mortise and tenon drill.

  4. Design and simulation of a cable-pulley-based transmission for artificial ankle joints

    Science.gov (United States)

    Liu, Huaxin; Ceccarelli, Marco; Huang, Qiang

    2016-06-01

    In this paper, a mechanical transmission based on cable pulley is proposed for human-like actuation in the artificial ankle joints of human-scale. The anatomy articular characteristics of the human ankle is discussed for proper biomimetic inspiration in designing an accurate, efficient, and robust motion control of artificial ankle joint devices. The design procedure is presented through the inclusion of conceptual considerations and design details for an interactive solution of the transmission system. A mechanical design is elaborated for the ankle joint angular with pitch motion. A multi-body dynamic simulation model is elaborated accordingly and evaluated numerically in the ADAMS environment. Results of the numerical simulations are discussed to evaluate the dynamic performance of the proposed design solution and to investigate the feasibility of the proposed design in future applications for humanoid robots.

  5. Bio-inspired design of geometrically interlocked 3D printed joints

    Science.gov (United States)

    Kumar, S.; Oliva, Noel; Kumar's Lab Team

    The morphology of the adhesive-adherend interface significantly affects the mechanical behavior of adhesive joints. As seen in some biocomposites like human skull, or the nacre of some bivalve molluscs' shells, a geometrically interlocking architecture of interfaces creates toughening and strengthening mechanisms enhancing the mechanical properties of the joint. In an attempt to characterize this mechanical interlocking mechanism, this study is focused on computational and experimental investigation of a single-lap joint with a very simple geometrically interlocked interface design in which both adherends have a square waveform configuration of the joining surfaces. This square waveform configuration contains a positive and a negative rectangular teeth per cycle in such a way that the joint is symmetric about the mid-bondlength. Both physical tests performed on 3D printed prototypes of joints and computational results indicate that the joints with square waveform design have higher strength and damage tolerance than those of joints with flat interface. In order to identify an optimal design configuration of this interface, a systematic parametric study is conducted by varying the geometric and material properties of the non-flat interface. This work was supported by Lockheed Martin (Award No: 12NZZ1).

  6. Designs and performance of three new microprocessor-controlled knee joints.

    Science.gov (United States)

    Thiele, Julius; Schöllig, Christina; Bellmann, Malte; Kraft, Marc

    2018-02-09

    A crossover design study with a small group of subjects was used to evaluate the performance of three microprocessor-controlled exoprosthetic knee joints (MPKs): C-Leg 4, Plié 3 and Rheo Knee 3. Given that the mechanical designs and control algorithms of the joints determine the user outcome, the influence of these inherent differences on the functional characteristics was investigated in this study. The knee joints were evaluated during level-ground walking at different velocities in a motion analysis laboratory. Additionally, technical analyses using patents, technical documentations and X-ray computed tomography (CT) for each knee joint were performed. The technical analyses showed that only C-Leg 4 and Rheo Knee 3 allow microprocessor-controlled adaptation of the joint resistances for different gait velocities. Furthermore, Plié 3 is not able to provide stance extension damping. The biomechanical results showed that only if a knee joint adapts flexion and extension resistances by the microprocessor all known advantages of MPKs can become apparent. But not all users may benefit from the examined functions: e.g. a good accommodation to fast walking speeds or comfortable stance phase flexion. Hence, a detailed comparison of user demands and performance of the designated knee joint is mandatory to ensure a maximum in user outcome.

  7. Extending TF1: Argument parsing, function composition, and vectorization

    CERN Document Server

    Tsang Mang Kin, Arthur Leonard

    2017-01-01

    In this project, we extend the functionality of the TF1 function class in root. We add argument parsing, making it possible to freely pass variables and parameters into pre-defined and user-defined functions. We also introduce a syntax to use certain compositions of functions, namely normalized sums and convolutions, directly in TF1. Finally, we introduce some simple vectorization functionality to TF1 and demonstrate the potential to speed up parallelizable computations.

  8. Cognitive Technologies: The Design of Joint Human-Machine Cognitive Systems

    OpenAIRE

    Woods, David D.

    1985-01-01

    This article explores the implications of one type of cognitive technology, techniques and concepts to develop joint human-machine cognitive systems, for the application of computational technology by examining the joint cognitive system implicit in a hypothetical computer consultant that outputs some form of problem solution. This analysis reveals some of the problems can occur in cognitive system design-e.g., machine control of the interaction, the danger of a responsibility-authority doubl...

  9. Development of design rules for adhesive bonded joints (Verfassung von Rechenregeln für Klebungen)

    NARCIS (Netherlands)

    Straalen, IJ.J. van

    2000-01-01

    This paper deals with the development of design rules for structural adhesive bonded joints. In daily practice engineers are confronted with the problem to verify the safety of their designs. Setting up an experimental programme can do this. For the marine, transport, building and civil engineering

  10. Use of probabilistic techniques to calibrate design rules for overlap joints

    NARCIS (Netherlands)

    Straalen, IJ.J. van; Botter, H.

    2005-01-01

    To apply design rules for overlap joints in practice, it is necessary to agree upon the partial safety for to be used. Values recommended in guidelines vary between 1,5 up to 10 or more. Since there is no conformation about the value to be used, a designer has to rely on his own judgement.

  11. Recommendations for fatigue design of welded joints and components

    CERN Document Server

    Hobbacher, A F

    2016-01-01

    This book provides a basis for the design and analysis of welded components that are subjected to fluctuating forces, to avoid failure by fatigue. It is also a valuable resource for those on boards or commissions who are establishing fatigue design codes. For maximum benefit, readers should already have a working knowledge of the basics of fatigue and fracture mechanics. The purpose of designing a structure taking into consideration the limit state for fatigue damage is to ensure that the performance is satisfactory during the design life and that the survival probability is acceptable. The latter is achieved by the use of appropriate partial safety factors. This document has been prepared as the result of an initiative by Commissions XIII and XV of the International Institute of Welding (IIW).

  12. FLOWTRAN-TF v1. 2 source code

    Energy Technology Data Exchange (ETDEWEB)

    Aleman, S.E.; Cooper, R.E.; Flach, G.P.; Hamm, L.L.; Lee, S.; Smith, F.G. III.

    1993-02-01

    The FLOWTRAN-TF code development effort was initiated in early 1989 as a code to monitor production reactor cooling systems at the Savannah River Plant. This report is a documentation of the various codes that make up FLOWTRAN-TF.

  13. FLOWTRAN-TF v1.2 source code

    Energy Technology Data Exchange (ETDEWEB)

    Aleman, S.E.; Cooper, R.E.; Flach, G.P.; Hamm, L.L.; Lee, S.; Smith, F.G. III

    1993-02-01

    The FLOWTRAN-TF code development effort was initiated in early 1989 as a code to monitor production reactor cooling systems at the Savannah River Plant. This report is a documentation of the various codes that make up FLOWTRAN-TF.

  14. Test Results of the First US ITER TF Conductor in SULTAN

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N N; Hatfield, D R; Miller, J R; Gung, C; Schultz, J S; Cheggour, N; Goodrich, L F; Bruzzone, P; Stepanov, B; Wesche, R; Seeber, B

    2008-08-18

    The US Domestic Agency is one of six parties supplying TF cable-in-conduit conductors (CICCs) for ITER. Previous tests have shown that measured performance of the TF CICCs can be much lower than expected from the strand properties at the projected uniaxial strain and that the cabling pattern may also be an important factor. Worst of all, voltage signals well below the expected critical surface could not be reliably interpreted or canceled, making test results very suspect. The TFUS1 sample was prepared to achieve multiple goals: (1) to ensure uniform current distribution and to eliminate parasitic voltage signals by improving joints, (2) to explore the potential benefits of a different cabling pattern for better support of strain-sensitive strands, and (3) to explore the source of voltage development in the cable through the use of innovative penetrating diagnostics. Test results of the first US-made samples are presented and discussed.

  15. New Joint Design to Create a More Natural and Efficient Biped

    Directory of Open Access Journals (Sweden)

    Giuseppina Gini

    2009-01-01

    Full Text Available This paper presents a human-oriented approach to design the mechanical architecture and the joint controller for a biped robot. Starting from the analysis of the human lower limbs, we figured out which features of the human legs are fundamental for a correct walking motion, and can be adopted in the mechanical design of a humanoid robot. We focus here on the knee, designed as a compliant human-like knee instead of a classical pin-joint, and on the foot, characterised by the mobility and lightness of the human foot. We implemented an elastic actuator, with a simple position control paradigm that sets the joint stiffness in real time, and developed the basic controller. Results in simulation are discussed. In our approach the robot gains in adaptability and energetic efficiency, which are the most challenging issues for a biped robot.

  16. Joint Optimal Design and Operation of Hybrid Energy Storage Systems

    NARCIS (Netherlands)

    Y. Ghiassi-Farrokhfal (Yashar); C. Rosenberg; S. Keshav (Srinivasam); M.-B. Adjaho (Marie-Benedicte)

    2016-01-01

    markdownabstractThe wide range of performance characteristics of storage technologies motivates the use of a hybrid energy storage systems (HESS) that combines the best features of multiple technologies. However, HESS design is complex, in that it involves the choice of storage technologies, the

  17. Strength and stiffness of tubular joints for assessment/design purposes

    Energy Technology Data Exchange (ETDEWEB)

    Dier, A.F.; Lalani, M.

    1995-12-01

    Tubular joints are integral components of offshore structures and, as such, many codes address their design. The strengths predicted by the codes often differ widely due to the adoption of different philosophies during code formulation and to differences in the underlying databases used during curve fitting and calibration exercises. In the assessment of existing structures, a hierarchy of analysis methods, from elastic analysis with improved code checks to nonlinear 3-D pushover analysis, may be employed. To avoid potentially unnecessary and expensive offshore strengthening work, it is important that these assessments are based on best estimates of joint strength (mean or characteristic, depending on application) and joint stiffness behavior. This paper gives the background to and interim results of a major international joint industry project in this area. Based on the most extensive carefully screened database ever assembled, the robustness of present design formulations have been examined, and new formulations have been developed where present codes are found wanting. Other issues, such as chord load, can length and material yield to ultimate strength have also been addressed. For the first time, expressions have been developed for P-{delta} and M-{theta} joint stiffness response, as may be used in advanced analysis including the simulation of joint behavior during pushover analysis. The paper goes on to describe the expected future developments in this field of technology.

  18. Design and Nonlinear Control of a 2-DOF Flexible Parallel Humanoid Arm Joint Robot

    Directory of Open Access Journals (Sweden)

    Leijie Jiang

    2017-01-01

    Full Text Available The paper focuses on the design and nonlinear control of the humanoid wrist/shoulder joint based on the cable-driven parallel mechanism which can realize roll and pitch movement. In view of the existence of the flexible parts in the mechanism, it is necessary to solve the vibration control of the flexible wrist/shoulder joint. In this paper, a cable-driven parallel robot platform is developed for the experiment study of the humanoid wrist/shoulder joint. And the dynamic model of the mechanism is formulated by using the coupling theory of the flexible body’s large global motion and small flexible deformation. Based on derived dynamics, antivibration control of the joint robot is studied with a nonlinear control method. Finally, simulations and experiments were performed to validate the feasibility of the developed parallel robot prototype and the proposed control scheme.

  19. Modeling and analysis of novel laser weld joint designs using optical ray tracing.

    Energy Technology Data Exchange (ETDEWEB)

    Milewski, J. O. (John O.)

    2002-01-01

    Reflection of laser energy presents challenges in material processing that can lead to process inefficiency or process instability. Understanding the fundamentals of non-imaging optics and the reflective propagation of laser energy can allow process and weld joint designs to take advantage of these reflections to enhance process efficiency or mitigate detrimental effects. Optical ray tracing may be used within a 3D computer model to evaluate novel joint and fixture designs for laser welding that take advantage of the reflective propagation of laser energy. This modeling work extends that of previous studies by the author and provides comparison with experimental studies performed on highly reflective metals. Practical examples are discussed.

  20. Joint Filter and Waveform Design for Radar STAP in Signal Dependent Interference

    OpenAIRE

    Setlur, Pawan; Rangaswamy, Muralidhar

    2015-01-01

    Waveform design is a pivotal component of the fully adaptive radar construct. In this paper we consider waveform design for radar space time adaptive processing (STAP), accounting for the waveform dependence of the clutter correlation matrix. Due to this dependence, in general, the joint problem of receiver filter optimization and radar waveform design becomes an intractable, non-convex optimization problem, Nevertheless, it is however shown to be individually convex either in the filter or i...

  1. A new approach to Stress Concentration Factors for tubular joint design

    Energy Technology Data Exchange (ETDEWEB)

    Tebbett, I.E.; Lalani, M.

    1984-05-01

    The fatigue design of tubular joints increasingly uses a single S-N curve based on the measured 'hot spot' stress range. Statistical analysis of the measured life delivers a corresponding design fatigue life with appropriately low probability of in-service failure. If a rigorous approach to probabilities is followed it is apparent that design should also address the reliability of predicting the 'hot spot' stress range for a given load and joint type. Finite element and acrylic model studies and many of the parametric formulae lack realism of the weld detail and cannot adequately cover the effects of weld profile variability and tubular tolerances. This paper presents the previously unpublished results of tests to determine Stress Concentration Factors for axial, in-plane and out-of-plane moment loading on over 30 steel tubular joints of realistic size and construction. It is apparent from the steel model tests that there is scatter in measured Stress Concentration Factors for nominally identical joints. These results are combined with the existing database of comparable tests and used to develop the concept of a design SCF defined in this paper. A detailed justification of the design formulae for SCFs is given. This new approach to SCFs incorporates the inherent variability of tubular joints in a manner which is consistent with the rigorous approach now being adopted for fatigue life assessment. This leads to a clearer understanding of the apparent scatter in observed performance of tubular joints and reduces the risk of gross underestimation of SCFs which is possible using current techniques.

  2. TfR2 expression in human colon carcinomas.

    Science.gov (United States)

    Calzolari, Alessia; Deaglio, Silvia; Maldi, Elena; Cassoni, Paola; Malavasi, Fabio; Testa, Ugo

    2009-01-01

    Different proteins regulate iron metabolism at the level of various tissues. Among these is a second transferrin receptor (TfR2) that seems to play a key role in the regulation of iron homeostasis. Although TfR2 expression in normal tissues is restricted at the level of the liver, we observed that TfR2 is frequently expressed in cancer cell lines. Taking advantage of this observation we investigated TfR2 expression in primary colon cancers, and showed that this receptor is expressed in about 26% of cases. TfR2 expression in colon cancer is not related to histological grade, but is preferentially associated with mucinous tumors. In colon cancer cell lines, TfR2 is localized in membrane lipid rafts, induces ERK1/ERK2 phosphorylation, when activated by its ligand transferring, and is preferentially expressed during S-M phases of the cell cycle. The presence of TfR2 on the membrane of colon cancer cells may contribute the growth advantage to these cells.

  3. Vacuum Bellows, Vacuum Piping, Cryogenic Break, and Copper Joint Failure Rate Estimates for ITER Design Use

    Energy Technology Data Exchange (ETDEWEB)

    L. C. Cadwallader

    2010-06-01

    The ITER international project design teams are working to produce an engineering design in preparation for construction of the International Thermonuclear Experimental Reactor (ITER) tokamak. During the course of this work, questions have arisen in regard to safety barriers and equipment reliability as important facets of system design. The vacuum system designers have asked several questions about the reliability of vacuum bellows and vacuum piping. The vessel design team has asked about the reliability of electrical breaks and copper-copper joints used in cryogenic piping. Research into operating experiences of similar equipment has been performed to determine representative failure rates for these components. The following chapters give the research results and the findings for vacuum system bellows, power plant stainless steel piping (amended to represent vacuum system piping), cryogenic system electrical insulating breaks, and copper joints.

  4. Jointly Decoded Raptor Codes: Analysis and Design for the BIAWGN Channel

    Directory of Open Access Journals (Sweden)

    Venkiah Auguste

    2009-01-01

    Full Text Available Abstract We are interested in the analysis and optimization of Raptor codes under a joint decoding framework, that is, when the precode and the fountain code exchange soft information iteratively. We develop an analytical asymptotic convergence analysis of the joint decoder, derive an optimization method for the design of efficient output degree distributions, and show that the new optimized distributions outperform the existing ones, both at long and moderate lengths. We also show that jointly decoded Raptor codes are robust to channel variation: they perform reasonably well over a wide range of channel capacities. This robustness property was already known for the erasure channel but not for the Gaussian channel. Finally, we discuss some finite length code design issues. Contrary to what is commonly believed, we show by simulations that using a relatively low rate for the precode , we can improve greatly the error floor performance of the Raptor code.

  5. Stiffeners layout design of thin-walled structures with constraints on multi-fastener joint loads

    Directory of Open Access Journals (Sweden)

    Jie HOU

    2017-08-01

    Full Text Available The purpose of this paper is to present an extended topology optimization method for the stiffeners layout design of aircraft assembled structures. Multi-fastener joint loads and manufacturing constraints are considered simultaneously. On one hand, the joint loads are calculated and constrained within a limited value to avoid the failure of fasteners. On the other hand, the manufacturing constraints of the material distribution in the machining directions of stiffeners are implemented by an improved piecewise interpolation based on a beveled cut-surface. It is proven that the objective function is strictly continuous and differentiable with respect to the piecewise interpolation. The effects of the extended method with two different constraints are highlighted by typical numerical examples. Compared with the standard topology optimization, the final designs have clearly shown the layout of stiffeners and the joint loads have been perfectly constrained to a satisfying level.

  6. Joint Base Station Clustering and Beamformer Design for Partial Coordinated Transmission in Heterogenous Networks

    CERN Document Server

    Hong, Mingyi; Baligh, Hadi; Luo, Zhi-Quan

    2012-01-01

    We consider the interference management problem in a multicell MIMO heterogenous network. Within each cell there are a large number of distributed micro/pico base stations (BSs) that can be potentially coordinated for joint transmission. To reduce coordination overhead, we consider user-centric BS clustering so that each user is served by only a small number of (potentially overlapping) BSs. Thus, given the channel state information, our objective is to jointly design the BS clustering and the linear beamformers for all BSs in the network. In this paper, we formulate this problem from a {sparse optimization} perspective, and propose an efficient algorithm that is based on iteratively solving a sequence of group LASSO problems. A novel feature of the proposed algorithm is that it performs BS clustering and beamformer design jointly rather than separately as is done in the existing approaches for partial coordinated transmission. Moreover, the cluster size can be controlled by adjusting a single penalty paramet...

  7. How Many Peripheral Solder Joints in a Surface Mounted Design Experience Inelastic Strains?

    Science.gov (United States)

    Suhir, E.; Yi, S.; Ghaffarian, R.

    2017-03-01

    It has been established that it is the peripheral solder joints that are the most vulnerable in the ball-grid-array (BGA) and column-grid-array (CGA) designs and most often fail. As far as the long-term reliability of a soldered microelectronics assembly as a whole is concerned, it makes a difference, if just one or more peripheral joints experience inelastic strains. It is clear that the low cycle fatigue lifetime of the solder system is inversely proportional to the number of joints that simultaneously experience inelastic strains. A simple and physically meaningful analytical expression (formula) is obtained for the prediction, at the design stage, of the number of such joints, if any, for the given effective thermal expansion (contraction) mismatch of the package and PCB; materials and geometrical characteristics of the package/PCB assembly; package size; and, of course, the level of the yield stress in the solder material. The suggested formula can be used to determine if the inelastic strains in the solder material could be avoided by the proper selection of the above characteristics and, if not, how many peripheral joints are expected to simultaneously experience inelastic strains. The general concept is illustrated by a numerical example carried out for a typical BGA package. The suggested analytical model (formula) is applicable to any soldered microelectronics assembly. The roles of other important factors, such as, e.g., solder material anisotropy, grain size, and their random orientation within a joint, are viewed in this analysis as less important factors than the level of the interfacial stress. The roles of these factors will be accounted for in future work and considered, in addition to the location of the joint, in a more complicated, more sophisticated, and more comprehensive reliability/fatigue model.

  8. Analysis and Design Optimization of a Compact and Lightweight Joint Torque Sensor for Space Manipulators

    Directory of Open Access Journals (Sweden)

    Nanzhe Wei

    2013-01-01

    Full Text Available This paper describes the development of a compact and lightweight joint torque sensor for space manipulators. Space manipulators with torque sensors can not only apply force control approach to more precise and more dexterous space missions, but also monitor the occurrence of unpredicted events as accidental impacts with objects they have to manipulate. At present, most of the compact torque sensors, designed without consideration of space environment, cannot be directly used in space applications. In this paper, we propose a compact and lightweight design for the joint torque sensor based on strain gauge, for the reason of good physical, chemical, and mechanical stabilities under high temperature environment. In addition, to reduce the interferences by axial forces generated by assembling condition and joint motors, the structural optimization for the sensing element is carried out. The proposed design is simulated by FEM software ANSYS, and it shows successful measurements of the torque with a load capacity of 10 Nm, which is sufficient for the torque generated in robot joints. The effect of axial loading is also analyzed by ANSYS. The designed sensor is manufactured by duralumin alloy. The calibration for the sensor is carried out, and several experiments are conducted to ensure its feasibility with the space manipulator.

  9. Limit analysis discussion of design methods for fracture of timber dowel joints loaded perpendicular to grain

    NARCIS (Netherlands)

    Van der Put, T.A.C.M.

    2014-01-01

    The results of an investigation of splitting of joints of [1] are used for a discussion of design methods and as necessary answer on comments and for confirmation of the extended fracture mechanics theory which accounts for the part of the external energy which is needed for plastic dissipation at

  10. Design of a 6-DOF upper limb rehabilitation exoskeleton with parallel actuated joints.

    Science.gov (United States)

    Chen, Yanyan; Li, Ge; Zhu, Yanhe; Zhao, Jie; Cai, Hegao

    2014-01-01

    In this paper, a 6-DOF wearable upper limb exoskeleton with parallel actuated joints which perfectly mimics human motions is proposed. The upper limb exoskeleton assists the movement of physically weak people. Compared with the existing upper limb exoskeletons which are mostly designed using a serial structure with large movement space but small stiffness and poor wearable ability, a prototype for motion assistance based on human anatomy structure has been developed in our design. Moreover, the design adopts balls instead of bearings to save space, which simplifies the structure and reduces the cost of the mechanism. The proposed design also employs deceleration processes to ensure that the transmission ratio of each joint is coincident.

  11. Virtual Welded-Joint Design Integrating Advanced Materials and Processing Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Z.; Dong, P.; Liu, S.; Babu, S.; Olson, G.; DebRoy, T.

    2005-04-15

    The primary goal of this project is to increase the fatigue life of a welded-joint by 10 times and to reduce energy use by 25% through product performance and productivity improvements using an integrated modeling approach. The fatigue strength of a welded-joint is currently the bottleneck to design high performance and lightweight welded structures using advanced materials such as high strength steels. In order to achieve high fatigue strength in a welded-joint it is necessary to manage the weld bead shape for lower stress concentration, produce preferable residual stress distribution, and obtain the desired microstructure for improved material toughness and strength. This is a systems challenge that requires the optimization of the welding process, the welding consumable, the base material, as well as the structure design. The concept of virtual welded-joint design has been proposed and established in this project. The goal of virtual welded-joint design is to develop a thorough procedure to predict the relationship of welding process, microstructure, property, residual stress, and the ultimate weld fatigue strength by a systematic modeling approach. The systematic approach combines five sub-models: weld thermal-fluid model, weld microstructure model, weld material property model, weld residual stress model, and weld fatigue model. The systematic approach is thus based on interdisciplinary applied sciences including heat transfer, computational fluid dynamics, materials science, engineering mechanics, and material fracture mechanics. The sub-models are based on existing models with further development. The results from modeling have been validated with critical experiments. The systematic modeling approach has been used to design high fatigue resistant welds considering the combined effects of weld bead geometry, residual stress, microstructure, and material property. In particular, a special welding wire has been developed in this project to introduce

  12. Design, fabrication and test of graphite/polyimide composite joints and attachments for advanced aerospace vehicles

    Science.gov (United States)

    Barclay, D. L.

    1980-01-01

    Results of an experimental program to develop several types of graphite/polyimide (GR/PI) bonded and bolted joints for lightly loaded flight components for advanced space transportation systems and high speed aircraft are presented. Tasks accomplished include: a literature survey; design of static discriminator specimens; design allowables testing; fabrication of test panels and specimens; small specimen testing; and standard joint testing. Detail designs of static discriminator specimens for each of the four major attachment types are presented. Test results are given for the following: (1) transverse tension of Celion 3000/PMR-15 laminate; (2) net tension of a laminate for both a loaded and unloaded bolt hole; (3) comparative testing of bonded and co-cured doublers along with pull-off tests of single and double bonded angles; (4) single lap shear tests, transverse tension and coefficient of thermal expansion tests of A7F (LARC-13 amide-imide modified) adhesive; and (5) tension tests of standard single lap, double lap, and symmetric step lap bonded joints. Also, included are results of a finite element analysis of a single lap bonded composite joint.

  13. Design of a welded joint for robotic, on-orbit assembly of space trusses

    Science.gov (United States)

    Rule, William K.

    1992-12-01

    In the future, some spacecraft will be so large that they must be assembled on-orbit. These spacecraft will be used for such tasks as manned missions to Mars or used as orbiting platforms for monitoring the Earth or observing the universe. Some large spacecraft will probably consist of planar truss structures to which will be attached special purpose, self-contained modules. The modules will most likely be taken to orbit fully outfitted and ready for use in heavy-lift launch vehicles. The truss members will also similarly be taken to orbit, but most unassembled. The truss structures will need to be assembled robotically because of the high costs and risks of extra-vehicular activities. Some missions will involve very large loads. To date, very few structures of any kind have been constructed in space. Two relatively simple trusses were assembled in the Space Shuttle bay in late 1985. Here the development of a design of a welded joint for on-orbit, robotic truss assembly is described. Mechanical joints for this application have been considered previously. Welded joints have the advantage of allowing the truss members to carry fluids for active cooling or other purposes. In addition, welded joints can be made more efficient structurally than mechanical joints. Also, welded joints require little maintenance (will not shake loose), and have no slop which would cause the structure to shudder under load reversal. The disadvantages of welded joints are that a more sophisticated assembly robot is required, weld flaws may be difficult to detect on-orbit, the welding process is hazardous, and welding introduces contamination to the environment. In addition, welded joints provide less structural damping than do mechanical joints. Welding on-orbit was first investigated aboard a Soyuz-6 mission in 1969 and then during a Skylab electron beam welding experiment in 1973. A hand held electron beam welding apparatus is currently being prepared for use on the MIR space station

  14. Design of the First Italian Roundabout with Jointed Plain Concrete Pavement

    Directory of Open Access Journals (Sweden)

    Paola Di Mascio

    2018-02-01

    Full Text Available This work presents the results of the overall design of the first Italian roundabout with jointed plain concrete pavement. The examined case study complies with current international standards and practices for geometry of roundabouts and road pavements. The construction of a concrete pavement in an urban roundabout will better manage and slow down fast vehicular flows, and increase traffic fluidity in an important junction, trafficked by heavy vehicles, where maintenance works should be reduced to avoid queues. The design of the roundabout involved several competences for: defining the geometry of the four-arm junction, designing the thickness of the jointed plain concrete pavement both on the circular crown and the arms, studying the mix design of a high resistance concrete. As regard to the pavement, the result of the study was an un-dowelled concrete pavement composed of square slabs laid on a cement concrete subbase and a granular layer. The shape of the slabs has been designed to optimize the structural performance of their material, which is a high strength concrete mix derived from an extensive laboratory test work. In general, the results summarized approaches typical of different design conditions: urban ones for traffic flow and safety needs; high-traffic ones for the chosen pavement type; airport ones for the absence of dowel and tie bars at the joints. Indeed, the article has highlighted that the design process of a concrete roundabout requires multiple analyses to consider various features and correctly re-design an existing urban junction. Its geometrical design, the structural design of the concrete pavement and the theoretical and experimental design of the concrete mix were the main phases of this process and they needed different competences to conduct comprehensive and appropriate analyses.

  15. Design, construction, and evaluation of "sensor lock": an electromechanical stance control knee joint.

    Science.gov (United States)

    Arazpour, Mokhtar; Ahmadi Bani, Monireh; Baniasad, Mina; Samadian, Mohammad; Golchin, Navid

    2017-03-28

    Most currently-available stance control knee ankle foot orthoses (SCKAFOs) still need full knee extension to lock the knee joint, and they are still noisy, bulky, and heavy. Therefore, the aim of this study was to design, construct, and evaluate an original electromechanical SCKAFO knee joint that could feasibly solve these problems, and thus address the problems of current stance control knee joints with regards to their structure, function, cosmesis, and cost. Ten able-bodied (AB) participants and two (knee ankle foot orthosis) KAFO users were recruited to participate in the study. A custom SCKAFO with the same set of components was constructed for each participant. Lower limb kinematics were captured using a 6-camera, video-based motion analysis system. For AB participants, significant differences were found between normal walking and walking with the SCKAFO for temporal-spatial parameters and between orthoses with two modes of knee joints in the healthy subjects. Walking with stance control mode produced greater walking speed and step length, greater knee flexion during swing, and less pelvic obliquity than walking with a locked knee, for both AB and KAFO users. The feasibility of this new knee joint with AB people was demonstrated. Implications for rehabilitation Stance control knee ankle foot orthoses (SCKAFOs) are designed to stop knee flexion in stance phase and provide free knee movement during swing phase of walking. Due to their high cost, size, excessive weight, and poor performance, few SCKAFO were optimal clinically and commercially. The feasibility of the new knee joint with able-bodied people and poliomyelitis subjects was demonstrated.

  16. Effect of lateralized design on muscle and joint reaction forces for reverse shoulder arthroplasty.

    Science.gov (United States)

    Liou, William; Yang, Yang; Petersen-Fitts, Graysen R; Lombardo, Daniel J; Stine, Sasha; Sabesan, Vani J

    2017-04-01

    Manufacturers of reverse shoulder arthroplasty (RSA) implants have recently designed innovative implants to optimize performance in rotator cuff-deficient shoulders. These advancements are not without tradeoffs and can have negative biomechanical effects. The objective of this study was to develop an integrated finite element analysis-kinematic model to compare the muscle forces and joint reaction forces (JRFs) of 3 different RSA designs. A kinematic model of a normal shoulder joint was adapted from the Delft model and integrated with the well-validated OpenSim shoulder model. Static optimizations then allowed for calculation of the individual muscle forces, moment arms, and JRFs relative to net joint moments. Three-dimensional computer models of 3 RSA designs-humeral lateralized design (HLD), glenoid lateralized design, and Grammont design-were integrated, and parametric studies were performed. Overall, there were decreases in deltoid and rotator cuff muscle forces for all 3 RSA designs. These decreases were greatest in the middle deltoid of the HLD model for abduction and flexion and in the rotator cuff muscles under both internal rotation and external rotation. The JRFs in abduction and flexion decreased similarly for all RSA designs compared with the normal shoulder model, with the greatest decrease seen in the HLD model. These findings demonstrate that the design characteristics implicit in these modified RSA prostheses result in mechanical differences most prominently seen in the deltoid muscle and overall JRFs. Further research using this novel integrated model can help guide continued optimization of RSA design and clinical outcomes. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  17. Optimization Algorithms for Calculation of the Joint Design Point in Parallel Systems

    DEFF Research Database (Denmark)

    Enevoldsen, I.; Sørensen, John Dalsgaard

    1992-01-01

    In large structures it is often necessary to estimate the reliability of the system by use of parallel systems. Optimality criteria-based algorithms for calculation of the joint design point in a parallel system are described and efficient active set strategies are developed. Three possible...... algorithms are tested in two examples against well-known general non-linear optimization algorithms. Especially one of the suggested algorithms seems to be stable and fast....

  18. Design and High Power Measurements of a 3 GHz Rotary Joint for Medical Applications

    CERN Document Server

    Degiovanni, Alberto; Garlasche, Marco; Giner-Navarro, Jorge; Magagnin, Paolo; Mcmonagle, Gerard; Syratchev, Igor; Wuensch, Walter

    2016-01-01

    The TUrning LInac for Protontherapy (TULIP) project requires the transport of RF power from modulator/klystron systems at rest on the floor to the linac structures mounted on a rotating gantry, via a waveguide system that can operate over a range of angles of rotation. A waveguide rotary joint capable of transporting RF power at 3 GHz and up to 20 MW has been designed and built in collaboration between TERA Foundation, CERN Beams and CERN Engineering Departments. A high-power test of the prototype has been performed at the CLIC Test Facility (CTF3), at CERN. The design and the results of the tests are reported in this article.

  19. The Design, Development, and Reliability Testing of a New Innovative Device to Measure Ankle Joint Dorsiflexion.

    Science.gov (United States)

    Charles, James

    2016-09-02

    In clinical and research settings, ankle joint dorsiflexion needs to be reliably measured. Dorsiflexion is often measured by goniometry, but the intrarater and interrater reliability of this technique have been reported to be poor. Many devices to measure dorsiflexion have been developed for clinical and research use. An evaluation of 12 current tools showed that none met all of the desirable criteria. The purpose of this study was to design and develop a device that rates highly in all of the criteria and that can be proved to be highly reliable. While supine on a treatment table, 14 participants had a foot placed in the Charles device and ankle joint dorsiflexion measured and recorded three times with a digital inclinometer. The mean of the three readings was determined to be the ankle joint dorsiflexion. The analysis used was intraclass correlation coefficient (ICC). There was very little difference in ICC single or average measures between left and right feet, so data were pooled (N = 28). The single-measure ICC was 0.998 (95% confidence interval, 0.996-0.998). The average-measure ICC was 0.998 (95% confidence interval, 0.995-0.999). Limits of agreement for the average measure were also very good: -1.30° to 1.65°. The Charles device meets all of the desirable criteria and has many innovative features, increasing its appropriateness for clinical and research applications. It has a suitable design for measuring dorsiflexion and high intrarater and interrater reliability.

  20. Joint Linear Filter Design in Multiuser Cooperative Nonregenerative MIMO Relay Systems

    Directory of Open Access Journals (Sweden)

    Li Gen

    2009-01-01

    Full Text Available This paper addresses the filter design issues for multiuser cooperative nonregenerative MIMO relay systems in both downlink and uplink scenarios. Based on the formulated signal model, the filter matrix optimization is first performed for direct path and relay path respectively, aiming to minimize the mean squared error (MSE. To be more specific, for the relay path, we derive the local optimal filter scheme at the base station and the relay station jointly in the downlink scenario along with a more practical suboptimal scheme, and then a closed-form joint local optimal solution in the uplink scenario is exploited. Furthermore, the optimal filter for the direct path is also presented by using the exiting results of conventional MIMO link. After that, several schemes are proposed for cooperative scenario to combine the signals from both paths. Numerical results show that the proposed schemes can reduce the bit error rate (BER significantly.

  1. Experimental Design for Evaluation of Co-extruded Refractory Metal/Nickel Base Superalloy Joints

    Energy Technology Data Exchange (ETDEWEB)

    ME Petrichek

    2005-12-16

    Prior to the restructuring of the Prometheus Program, the NRPCT was tasked with delivering a nuclear space reactor. Potential NRPCT nuclear space reactor designs for the Prometheus Project required dissimilar materials to be in contact with each other while operating at extreme temperatures under irradiation. As a result of the high reactor core temperatures, refractory metals were the primary candidates for many of the reactor structural and cladding components. They included the tantalum-base alloys ASTAR-811C and Ta-10W, the niobium-base alloy FS-85, and the molybdenum base alloys Moly 41-47.5 Rhenium. The refractory metals were to be joined to candidate nickel base alloys such as Haynes 230, Alloy 617, or Nimonic PE 16 either within the core if the nickel-base alloys were ultimately selected to form the outer core barrel, or at a location exterior to the core if the nickel-base alloys were limited to components exterior to the core. To support the need for dissimilar metal joints in the Prometheus Project, a co-extrusion experiment was proposed. There are several potential methods for the formation of dissimilar metal joints, including explosive bonding, friction stir welding, plasma spray, inertia welding, HIP, and co-extrusion. Most of these joining methods are not viable options because they result in the immediate formation of brittle intermetallics. Upon cooling, intermetallics form in the weld fusion zone between the joined metals. Because brittle intermetallics do not form during the initial bonding process associated with HIP, co-extrusion, and explosive bonding, these three joining procedures are preferred for forming dissimilar metal joints. In reference to a Westinghouse Astronuclear Laboratory report done under a NASA sponsored program, joints that were fabricated between similar materials via explosive bonding had strengths that were directly affected by the width of the diffusion barrier. It was determined that the diffusion zone should not exceed

  2. Design of an ultra-high torque double shoulder drill-pipe tool joint for extended reach wells

    Directory of Open Access Journals (Sweden)

    Xiaohua Zhu

    2017-09-01

    Full Text Available Drill-pipe tool joints in extended reach wells often suffer a shear failure. In view of this, an ultra-high torque double-shoulder pipe joint was designed according to the deformation compatibility relation of the drill-pipe tool joint under torque. It is structurally characterized by long primary and secondary shoulders, small thread taper and large fillet radius of bottom tooth. First, a 3D numerical simulation model was established for this type of joint, named the XSJ joint here, based on the principle of virtual work, the Von Mises yield criterion and the nonlinear contact theory. Second, orthogonal optimization was performed on its key structural parameters by means of the orthogonal optimization method. The optimal combination of key structural parameters of the XSJ joint is taper 1:16, thread pitch 6.55 mm, guiding surface angle 29°, bearing surface angle 28°, and tooth height 3.755 mm. Finally, the bearing performance and fatigue performance of this tool joint and the API tool joint were calculated and compared using the Simulia Abaqus fe-safe software. Compared with the API tool joint, the XSJ joint is better, and its tensile strength, torsion strength, bending strength and compression strength increase by 10.65%, 62.5%, 2.75% and 52%, respectively. Its tension compression fatigue life, bending fatigue life, torsion fatigue life and composite fatigue life increase by 1.19 times, 1.74 times, 550 times and 28.79%, respectively. It is concluded that the designed XSJ joint is significantly improved in term of torsion capacity while its tension strength, bending strength and compression strength are not decreased, so it can better meet the drilling conditions of extended reach wells. Keywords: Extended reach well, Tool joint, Shear failure, Torsion capacity, Bending capacity, Orthogonal optimization, Bearing property, Fatigue life

  3. Design and development of an intelligent nursing bed - a pilot project of "joint assignment".

    Science.gov (United States)

    Jiehui Jiang; Tingwei Liu; Yuting Zhang; Yu Song; Mi Zhou; Xiaosong Zheng; Zhuangzhi Yan

    2017-07-01

    The "joint assignment" is a creative bachelor education project for Biomedical Engineering (BME) in Shanghai University (SHU), China. The objective of this project is to improve students' capabilities in design thinking and teamwork through practices in the process of the design and development of complex medical product. As the first step, a pilot project "design and development of intelligent nursing bed" was set up in May 2015. This paper describes details of how project organization and management, various teaching methods and scientific evaluation approaches were achieved in this pilot project. For example, a method containing one main line and four branches is taken to manage the project and "prototyping model" was used as the main research approach. As a result a multi-win situation was achieved. The results showed, firstly, 62 bachelor students including 16 BME students were well trained. They improved themselves in use of practical tools, communication skills and scientific writing; Secondly, commercial companies received a nice product design on intelligent nursing bed, and have been working on industrializing it; Thirdly, the university and associated schools obtained an excellent practical education experience to supplement traditional class education; Fourthly and most importantly, requirements from end-users will be met. The results also showed that the "joint assignment" task could become a significant component in BME bachelor education.

  4. Influence of Welding Current and Joint Design on the Tensile Properties of SMAW Welded Mild Steel Joints Prof. Rohit Jha1 , Dr. A.K. Jha

    OpenAIRE

    Prof. Rohit Jha; Dr. A.K. Jha

    2014-01-01

    Present study includes welding characteristics of weldment with respect to different types of weld design and welding current. Mild steel plates of 6mm were welded using different joint designs. Single V, Double V and Flat surfaces were joined by Shielded Metal Arc Welding process. Welding current was varied in all the cases. Mechanical properties such as ultimate tensile strength, yield strength and percentage elongation were evaluated. Results indicated that the single V join...

  5. Expression of antigen tf and galectin-3 in fibroadenoma

    Directory of Open Access Journals (Sweden)

    Gallegos Itandehui Belem

    2012-12-01

    Full Text Available Abstract Background Fibroadenomas are benign human breast tumors, characterized by proliferation of epithelial and stromal components of the terminal ductal unit. They may grow, regress or remain unchanged, as the hormonal environment of the patient changes. Expression of antigen TF in mucin or mucin-type glycoproteins and of galectin-3 seems to contribute to proliferation and transformations events; their expression has been reported in ductal breast cancer and in aggressive tumors. Findings Lectin histochemistry, immunohistochemistry, and immunofluorescence were used to examine the expression and distribution of antigen TF and galectin-3. We used lectins from Arachis hypogaea, Artocarpus integrifolia, and Amaranthus lecuocarpus to evaluate TF expression and a monoclonal antibody to evaluate galectin-3 expression. We used paraffin-embedded blocks from 10 breast tissues diagnosed with fibroadenoma and as control 10 healthy tissue samples. Histochemical and immunofluorescence analysis showed positive expression of galectin-3 in fibroadenoma tissue, mainly in stroma, weak interaction in ducts was observed; whereas, in healthy tissue samples the staining was also weak in ducts. Lectins from A. leucocarpus and A. integrifolia specificaly recognized ducts in healthy breast samples, whereas the lectin from A. hypogaea recognized ducts and stroma. In fibroadenoma tissue, the lectins from A. integrifolia, A. Hypogaea, and A. leucocarpus recognized mainly ducts. Conclusions Our results suggest that expression of antigen TF and galectin-3 seems to participate in fibroadenoma development.

  6. Term frequency inverse document frequency (TF-IDF) technique and ...

    African Journals Online (AJOL)

    Term frequency inverse document frequency (TF-IDF) technique and artificial neural network in email classification system. ... This has inspired attention for urgent need to manage and maintain e-mail. Email messages are expected to be sent and gathered in a warehouse for recurring use as it ranges from inert institutional ...

  7. Analysis of current and voltage distribution in the first Japanese qualification sample of an ITER TF conductor

    Science.gov (United States)

    Koizumi, Norikiyo; Matsui, Kunihiro; Okuno, Kiyoshi

    2010-03-01

    The critical currents of the Japanese ITER TF conductors made through an internal-tin and bronze process were preliminarily estimated to be about 5.7 K, which approximates the design value of 5.7 K, and about 6.1 K, respectively, at 68 kA and 11.8 T using a short conductor sample. To investigate the influence of the current distribution in the sample conductor, a simulation was performed using a lumped circuit model of a cable and static electrical field model for jackets. The simulation results show that a large, non-uniform current distribution is established due to magneto-resistance of the copper in the joint and an imbalance of contact resistance of the strands to the copper and by poor soldering between the copper shoes, results which make a precise evaluation of the critical current performance difficult. The analytical results indicate that the current sharing temperature of the internal-tin and bronze process conductors is expected to be 6.0 K and 6.7 K, respectively, when the current distribution is uniform. In addition, solder filling of the joints makes the current distribution uniform due to the normal resistance in the high field zone, and the current sharing temperature can be estimated as almost the same as when the current distribution is uniform. The other possible solution is to use a thin copper plate with a low RRR to reduce the influence of magneto-resistance and any non-uniformity in contact resistance. Conductor performance is under-estimated in this case because the non-uniform current distribution still remains. However, the reduction in the estimated current sharing temperature is expected to be a few hundred milli-Kelvins, which seems acceptable as a margin in a qualification trial.

  8. Organizational transformation: a model for joint optimization of culture change and evidence-based design.

    Science.gov (United States)

    Hamilton, D Kirk; Orr, Robin Diane; Raboin, W Ellen

    2008-01-01

    Healthcare organizations face continuous and accelerating external change and thus must be prepared to manage their own change initiatives proactively. Given that many believe that the U.S. healthcare system is broken and most healthcare organizations are dealing with pervasive problems, some organizations may choose to seek transformational change to achieve the six aims identified by the Institute of Medicine: healthcare that is safe, effective, patient-centered, timely, efficient, and equitable. Transformational change will almost certainly involve organizational culture. Culture change may be most effective when linked to other organizational change initiatives such as organizational strategy, structure, policies, procedures, and recruiting. Significant organizational change often requires accompanying facility change. There is an interdependent relationship between facility design and organizational culture. They affect each other and both impact organizational performance. Sociotechnical theory promotes joint optimization of the social (culture) and technical (facilities) aspects of an organization to achieve sustained positive change. To achieve organizational transformation and to sustain positive change, organizations must be prepared to adopt collaborative efforts in culture change and facility design. The authors propose a model for accomplishing joint optimization of culture change and evidence-based facility design.

  9. Analysis and design of rolling-contact joints for evaluating bone plate performance.

    Science.gov (United States)

    Slocum, Alexander H; Cervantes, Thomas M; Seldin, Edward B; Varanasi, Kripa K

    2012-09-01

    An apparatus for testing maxillofacial bone plates has been designed using a rolling contact joint. First, a free-body representation of the fracture fixation techniques utilizing bone plates is used to illustrate how rolling contact joints accurately simulate in vivo biomechanics. Next, a deterministic description of machine functional requirements is given, and is then used to drive the subsequent selection and design of machine elements. Hertz contact stress and fatigue analysis for two elements are used to ensure that the machine will both withstand loads required to deform different plates, and maintain a high cycle lifetime for testing large numbers of plates. Additionally, clinically relevant deformations are presented to illustrate how stiffness is affected after a deformation is applied, and to highlight improvements made by the machine over current testing standards, which do not adequately re-create in vivo loading conditions. The machine performed as expected and allowed for analysis of bone plates in both deformed and un-deformed configurations to be conducted. Data for deformation experiments is presented to show that the rolling-contact testing machine leads to improved loading configurations, and thus a more accurate description of plate performance. A machine for evaluation of maxillofacial bone plates has been designed, manufactured, and used to accurately simulate in vivo loading conditions to more effectively evaluate the performance of both new and existing bone plates. Copyright © 2012 IPEM. Published by Elsevier Ltd. All rights reserved.

  10. Spatial-Mode Selection for the Joint Transmit and Receive MMSE Design

    Directory of Open Access Journals (Sweden)

    Thoen Steven

    2004-01-01

    Full Text Available To approach the potential MIMO capacity while optimizing the system bit error rate (BER performance, the joint transmit and receive minimum mean squared error (MMSE design has been proposed. It is the optimal linear scheme for spatial multiplexing MIMO systems, assuming a fixed number of spatial streams as well as a fixed modulation and coding across these spatial streams. However, state-of-the-art designs arbitrarily choose and fix the value of the number of spatial streams , which may lead to an inefficient power allocation strategy and a poor BER performance. We have previously proposed to relax the constraint of fixed number of streams and to optimize this value under the constraints of fixed average total transmit power and fixed spectral efficiency, which we referred to as spatial-mode selection. Our previous selection criterion was the minimization of the system sum MMSE. In the present contribution, we introduce a new and better spatial-mode selection criterion that targets the minimization of the system BER. We also provide a detailed performance analysis, over flat-fading channels, that confirms that our proposed spatial-mode selection significantly outperforms state-of-the-art joint Tx/Rx MMSE designs for both uncoded and coded systems, thanks to its better exploitation of the MIMO spatial diversity and more efficient power allocation.

  11. THE PROBLEM OF THE FEASIBILITY STUDY IN RESPECT OF DESIGN OF JOINTS OF METAL STRUCTURES

    Directory of Open Access Journals (Sweden)

    Morozova Dina Vol'demarovna

    2012-12-01

    It is noteworthy that this problem enjoyed much attention back in the past when the country suffered from steel deficit, and metal processing plants could not keep up with the needs of consumers. This problem was dealt with by Y.M. Lihtarnikov, a Soviet scientist, who published his work "Variant design and optimization of steel structures" in 1979. The authors employ the theoretical base developed by the scientist to perform their research into the optimum solutions to the problems of several types of metal joints.

  12. Design of a simple, lightweight, passive-elastic ankle exoskeleton supporting ankle joint stiffness

    Science.gov (United States)

    Kim, Seyoung; Son, Youngsu; Choi, Sangkyu; Ham, Sangyong; Park, Cheolhoon

    2015-09-01

    In this study, a passive-elastic ankle exoskeleton (PEAX) with a one-way clutch mechanism was developed and then pilot-tested with vertical jumping to determine whether the PEAX is sufficiently lightweight and comfortable to be used in further biomechanical studies. The PEAX was designed to supplement the function of the Achilles tendon and ligaments as they passively support the ankle torque with their inherent stiffness. The main frame of the PEAX consists of upper and lower parts connected to each other by tension springs (N = 3) and lubricated hinge joints. The upper part has an offset angle of 5° with respect to the vertical line when the springs are in their resting state. Each spring has a slack length of 8 cm and connects the upper part to the tailrod of the lower part in the neutral position. The tailrod freely rotates with low friction but has a limited range of motion due to the stop pin working as a one-way clutch. Because of the one-way clutch system, the tension springs store the elastic energy only due to an ankle dorsiflexion when triggered by the stop pin. This clutch mechanism also has the advantage of preventing any inconvenience during ankle plantarflexion because it does not limit the ankle joint motion during the plantarflexion phase. In pilot jumping tests, all of the subjects reported that the PEAX was comfortable for jumping due to its lightweight (approximately 1 kg) and compact (firmly integrated with shoes) design, and subjects were able to nearly reach their maximum vertical jump heights while wearing the PEAX. During the countermovement jump, elastic energy was stored during dorsiflexion by spring extension and released during plantarflexion by spring restoration, indicating that the passive spring torque (i.e., supportive torque) generated by the ankle exoskeleton partially supported the ankle joint torque throughout the process.

  13. Two implant/abutment joint designs: a comparative finite element analysis.

    Science.gov (United States)

    Khraisat, Ameen

    2013-01-01

    The aim of this study was to compare the influence of abutment screw preload on the marginal bone stress around a conventional external-hex implant system and one with a new implant/abutment joint design. Two implant/bone models, each consisting of three parts and fabricated of titanium and bone (cortical), were built and arranged with computer-aided design software. The first model represented an external-hex implant system, while the second had a tapered extension over the external hex, 1.5 mm high, so that the apical extension of the abutment screw in the assembly did not go beyond the lower level of the implant shoulder. Meshing and generation of boundary conditions, loads, and interactions were performed for the two models. All parts were meshed independent of each other. The sole load applied on the model was a torque of 32 Ncm on the abutment screw about its axis of rotation. The first model showed deformation of the implant collar, and the resulting von Mises stress was 60 MPa in the marginal bone. In contrast, no deformation was observed in the second model. The new implant/abutment joint eliminated the deformation at the implant collar area caused by the application of tightening torque and thus eliminated the resulting stresses in the marginal bone.

  14. An Approach to Optimum Joint Beamforming Design in a MIMO-OFDM Multiuser System

    Directory of Open Access Journals (Sweden)

    Pascual-Iserte Antonio

    2004-01-01

    Full Text Available This paper describes a multiuser scenario with several terminals acceding simultaneously to the same frequency channel. The objective is to design an optimal multiuser system that may be used as a comparative framework when evaluating other suboptimal solutions and to contribute to the already published works on this topic. The present work assumes that a centralized manager knows perfectly all the channel responses between all the terminals. According to this, the transmitters and receivers, using antenna arrays and leading to the so-called multiple-input-multiple-output (MIMO channels, are designed in a joint beamforming approach, attempting to minimize the total transmit power subject to quality of service (QoS constraints. Since this optimization problem is not convex, the use of the simulated annealing (SA technique is proposed to find the optimum solution.

  15. D7.21 Report on Validation of design of grouted joints Work Package 7.2

    DEFF Research Database (Denmark)

    Gintautas, Tomas; Sørensen, John Dalsgaard

    2017-01-01

    Grouted joints for offshore wind turbines forming the connection between the transition piece to the monopile and tower are one of the weakest links of the support structure. The grout being a reinforced concrete material is susceptible to cyclic loading comprising of tensile and compressive...... components. As offshore wind turbines reach 10 MW capacities, it is extremely important to determine the reliability of grouted joints and their design configurations so as to ensure integrity of the 10 MW support structure. This report investigates two types of grouted joint connections, the conventional...

  16. Joint ENEA-ANSALDO design and manufacturing feasibility study of a brazed first wall for NET

    Energy Technology Data Exchange (ETDEWEB)

    Franconi, E.; Rado, V.; Simbolotti, G.; Violante, V.; Zampaglione, V. (Associazione Euratom-ENEA, Frascati (Italy). Centro Ricerche Energia); Avanzini, P.G.; Brossa, M.; Casali, D.; Grattarola, M.; Guerreschi, M.; Rosatelli, F. (Ansaldo S.p.A., Genoa (Italy)); Vieider, G. (Max-Planck-Institut fuer Plasmaphysik, Garching (Germany, F.R.)); NET Team

    1989-05-01

    In collaboration with ANSALDO, ENEA is performing a design and manufacturing feasibility study for the first wall of NET during the physics operation phase. The main design specifications are the average neutron wall load=1 MW/m/sup 2/, peak surface heat flux=0.4 MW/m/sup 2/, total number of burn pulses=1x10/sup 4/, average burn pulse duration=100 s, structure material=ss 316L S.A., coolant=H/sub 2/O (He) at 50/sup 0/C. The ENEA-ANSALDO reference design is based on the use of flat plates coupled by nicrobrazing to water poloidal cooling tubes. The final aim of the work is manufacturing a representative NET first wall box segment (mockup of indicative dimensions 0.65x0.25x0.15 m/sup 3/) suitable for testing in the 190 kW Thermal Fatigue Test Facility at JRC-Ispra. In this paper we report on the related design work and the results of the studied performed: Technological development (manufacturing test activity, brazed joints characterization tests, mockup design and manufacturing), thermomechanical analysis, plasma-wall interaction studies (test on protective carbon composite material, theory), and tritium transport analysis. (orig.).

  17. Thermal-hydraulic analysis of LTS cables for the DEMO TF coil using simplified models

    Directory of Open Access Journals (Sweden)

    Lewandowska Monika

    2017-03-01

    Full Text Available The conceptual design activities for the DEMOnstration reactor (DEMO – the prototype fusion power plant – are conducted in Europe by the EUROfusion Consortium. In 2015, three design concepts of the DEMO toroidal field (TF coil were proposed by Swiss Plasma Center (EPFL-SPC, PSI Villigen, Italian National Agency for New Technologies (ENEA Frascati, and Atomic Energy and Alternative Energies Commission (CEA Cadarache. The proposed conductor designs were subjected to complete mechanical, electromagnetic, and thermal-hydraulic analyses. The present study is focused on the thermal-hydraulic analysis of the candidate conductor designs using simplified models. It includes (a hydraulic analysis, (b heat removal analysis, and (c assessment of the maximum temperature and the maximum pressure in each conductor during quench. The performed analysis, aimed at verification whether the proposed design concepts fulfil the established acceptance criteria, provides the information for further improvements of the coil and conductors design.

  18. Engineering, Manufacture and Preliminary Testing of the ITER Toroidal Field (TF) Magnet Helium Cold Circulator

    Science.gov (United States)

    Rista, P. E. C.; Shull, J.; Sargent, S.

    2015-12-01

    The ITER cryodistribution system provides the supercritical Helium (SHe) forced flow cooling to the magnet system using cold circulators. The cold circulators are located in each of five separate auxiliary cold boxes planned for use in the facility. Barber-Nichols Inc. has been awarded a contract from ITER-India for engineering, manufacture and testing of the Toroidal Field (TF) Magnet Helium Cold Circulator. The cold circulator will be extensively tested at Barber-Nichols’ facility prior to delivery for qualification testing at the Japan Atomic Energy Agency's (JAEA) test facility at Naka, Japan. The TF Cold Circulator integrates features and technical requirements which Barber-Nichols has utilized when supplying helium cold circulators worldwide over a period of 35 years. Features include a vacuum-jacketed hermetically sealed design with a very low helium leak rate, a heat shield for use with both nitrogen & helium cold sources, a broad operating range with a guaranteed isentropic efficiency over 70%, and impeller design features for high efficiency. The cold circulator will be designed to meet MTBM of 17,500 hours and MTBF of 36,000 hours. Vibration and speed monitoring are integrated into a compact package on the rotating assembly with operation and health monitoring in a multi-drop PROFIBUS communication environment using an electrical cabinet with critical features and full local and network PLC interface and control. For the testing in Japan and eventual installation in Europe, the cold circulator must be certified to the Japanese High Pressure Gas Safety Act (JHPGSA) and CE marked in compliance with the European Pressure Equipment Directive (PED) including Essential Safety Requirements (ESR). The test methodology utilized at Barber-Nichols’ facility and the resulting test data, validating the high efficiency of the TF Cold Circulator across a broad operating range, are important features of this paper.

  19. Tapered joint design for power transmission of MW-grade wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Jong Hun; Bae, Jun Woo; Oh, Han Yong [Dept. of Mechatronics, Jungwon University, Geosan (Korea, Republic of); Kwon, Yong Chul [Kyeongnam Technopark, Changwon (Korea, Republic of)

    2015-11-15

    This study focuses on the design of the tapered joints of a wind power turbine. The main variables of the tapered joint are the transmitted torque, shaft diameter, contact area of the tapered ring, and tightening torque of the bolts, which applies a compressive pressure from the hub to the shaft. The stress distribution of the taper fit was calculated under axisymmetric plane strain conditions because of the small taper angle. The axial displacement of the clamp can be calculated from the radial elastic deformation and the taper angle. The stress field of each ring is obtained from the cylinder stress equation. To verify the accuracy of the calculation, finite element (FE) analysis was performed, and the results of the calculation and FE analysis were compared. The hoop stress of the tapered surface showed a discrepancy of approximately 10, but the trends of the stress distributions of each component and the relative movement obtained by FE analysis were in good agreement with the analytical calculation results.

  20. BOREAS TF-11 SSA Fen 1996 Water Surface Film Capping Data

    Data.gov (United States)

    National Aeronautics and Space Administration — Contains the TF-11 CO2 chamber flux measurements made with the LI-6200 under water surface film conditions and the TF-11 CO2 chamber concentration measurements made...

  1. Joint Source and Relay Precoding Designs for MIMO Two-Way Relaying Based on MSE Criterion

    CERN Document Server

    Wang, Rui

    2011-01-01

    Properly designed precoders can significantly improve the spectral efficiency of multiple-input multiple-output (MIMO) relay systems. In this paper, we investigate joint source and relay precoding design based on the mean-square-error (MSE) criterion in MIMO two-way relay systems, where two multi-antenna source nodes exchange information via a multi-antenna amplify-and-forward relay node. This problem is non-convex and its optimal solution remains unsolved. Aiming to find an efficient way to solve the problem, we first decouple the primal problem into three tractable sub-problems, and then propose an iterative precoding design algorithm based on alternating optimization. The solution to each sub-problem is optimal and unique, thus the convergence of the iterative algorithm is guaranteed. Secondly, we propose a structured precoding design to lower the computational complexity. The proposed precoding structure is able to parallelize the channels in the multiple access (MAC) phase and broadcast (BC) phase. It th...

  2. Cooperative joint precoding in a downlink cellular system with shared relay: Design and performance evaluation

    KAUST Repository

    Kwon, JaeWoo

    2012-10-01

    In this paper, we investigate a relay enhanced cellular system, where a relay station is located in the overlap area served by two base stations. We propose cooperative joint precoding schemes for the downlink transmission of such relay enhanced cellular system to maximize the system capacity while minimizing the interference at both the relay station and the mobile stations. We formulate the optimization problems to maximize the system capacity and design the multiuser precoding vectors at each base station and the relay station. We quantify the ergodic rate performance of the proposed multiuser precoding schemes through statistical analysis. The extensively derived ergodic expressions will facilitate the accurate performance evaluation of the proposed transmission schemes. Numerical results show that the proposed schemes can effectively cancel the interference and improve the sum rate and the outage performance for cell edge users. © 2002-2012 IEEE.

  3. Performance evaluation of the Ingenuity TF PET/CT scanner with a focus on high count-rate conditions

    Science.gov (United States)

    Kolthammer, Jeffrey A.; Su, Kuan-Hao; Grover, Anu; Narayanan, Manoj; Jordan, David W.; Muzic, Raymond F.

    2014-07-01

    This study evaluated the positron emission tomography (PET) imaging performance of the Ingenuity TF 128 PET/computed tomography (CT) scanner which has a PET component that was designed to support a wider radioactivity range than is possible with those of Gemini TF PET/CT and Ingenuity TF PET/MR. Spatial resolution, sensitivity, count rate characteristics and image quality were evaluated according to the NEMA NU 2-2007 standard and ACR phantom accreditation procedures; these were supplemented by additional measurements intended to characterize the system under conditions that would be encountered during quantitative cardiac imaging with 82Rb. Image quality was evaluated using a hot spheres phantom, and various contrast recovery and noise measurements were made from replicated images. Timing and energy resolution, dead time, and the linearity of the image activity concentration, were all measured over a wide range of count rates. Spatial resolution (4.8-5.1 mm FWHM), sensitivity (7.3 cps kBq-1), peak noise-equivalent count rate (124 kcps), and peak trues rate (365 kcps) were similar to those of the Gemini TF PET/CT. Contrast recovery was higher with a 2 mm, body-detail reconstruction than with a 4 mm, body reconstruction, although the precision was reduced. The noise equivalent count rate peak was broad (within 10% of peak from 241-609 MBq). The activity measured in phantom images was within 10% of the true activity for count rates up to those observed in 82Rb cardiac PET studies.

  4. Joint Hybrid Backhaul and Access Links Design in Cloud-Radio Access Networks

    KAUST Repository

    Dhifallah, Oussama Najeeb

    2015-09-06

    The cloud-radio access network (CRAN) is expected to be the core network architecture for next generation mobile radio systems. In this paper, we consider the downlink of a CRAN formed of one central processor (the cloud) and several base station (BS), where each BS is connected to the cloud via either a wireless or capacity-limited wireline backhaul link. The paper addresses the joint design of the hybrid backhaul links (i.e., designing the wireline and wireless backhaul connections from the cloud to the BSs) and the access links (i.e., determining the sparse beamforming solution from the BSs to the users). The paper formulates the hybrid backhaul and access link design problem by minimizing the total network power consumption. The paper solves the problem using a two-stage heuristic algorithm. At one stage, the sparse beamforming solution is found using a weighted mixed 11/12 norm minimization approach; the correlation matrix of the quantization noise of the wireline backhaul links is computed using the classical rate-distortion theory. At the second stage, the transmit powers of the wireless backhaul links are found by solving a power minimization problem subject to quality-of-service constraints, based on the principle of conservation of rate by utilizing the rates found in the first stage. Simulation results suggest that the performance of the proposed algorithm approaches the global optimum solution, especially at high signal-to-interference-plus-noise ratio (SINR).

  5. Biomechanical design of escalading lower limb exoskeleton with novel linkage joints.

    Science.gov (United States)

    Zhang, Guoan; Liu, Gangfeng; Ma, Sun; Wang, Tianshuo; Zhao, Jie; Zhu, Yanhe

    2017-07-20

    In this paper, an obstacle-surmounting-enabled lower limb exoskeleton with novel linkage joints that perfectly mimicked human motions was proposed. Currently, most lower exoskeletons that use linear actuators have a direct connection between the wearer and the controlled part. Compared to the existing joints, the novel linkage joint not only fitted better into compact chasis, but also provided greater torque when the joint was at a large bend angle. As a result, it extended the angle range of joint peak torque output. With any given power, torque was prioritized over rotational speed, because instead of rotational speed, sufficiency of torque is the premise for most joint actions. With insufficient torque, the exoskeleton will be a burden instead of enhancement to its wearer. With optimized distribution of torque among the joints, the novel linkage method may contribute to easier exoskeleton movements.

  6. GENIUS-TF: a test facility for the GENIUS project

    Science.gov (United States)

    Klapdor-Kleingrothaus, H. V.; Baudis, L.; Dietz, A.; Heusser, G.; Krivosheina, I.; Majorovits, B.; Strecker, H.

    2002-04-01

    GENIUS is a proposal for a large scale detector of rare events. As a first step of the experiment, a small test version, the Genius Test-Facility will be built at the Laboratori Nazionali del Gran Sasso. With about 40kg of natural Ge detectors operated in liquid nitrogen, GENIUS-TF could exclude (or directly confirm) the DAMA annual modulation seasonal modulation signature within about 2yr of measurement using both, signal and signature of the claimed WIMP Dark Matter. The construction of the experiment has already been started, and four 2.5kg germanium detectors with an extreme low threshold of 500eV have been produced.

  7. International Joint Project of Engineering Design Education among Three Institutions in Japan, U.S. and Singapore

    Science.gov (United States)

    Matsuishi, Masakatsu; Takemata, Kazuya; Furukawa, Tetsuro; Sanders, Wayne; Loo, Chin Non

    An international joint program of Engineering Design has started in 2004 between Kanazawa Institute of Technology, Singapore Polytechnic in Singapore, and Rose-Hulman Institute of Technology in the United States. Students from the three institutions worked on the same engineering design project, the main theme of which was, “Bus Transportation/Urban Transportation System in the 21st Century”. Student teams chose their own project themes from specific design areas, which were related to the main theme. Their achievements were unique in their solutions due to the differences in society and culture in Japan, the United States and Singapore, although all the design teams followed the same engineering design procedures. In this paper, the international joint project is discussed in details.

  8. The Influence of PV Module Materials and Design on Solder Joint Thermal Fatigue Durability

    Energy Technology Data Exchange (ETDEWEB)

    Bosco, Nick; Silverman, Timothy J.; Kurtz, Sarah

    2016-11-01

    Finite element model (FEM) simulations have been performed to elucidate the effect of flat plate photovoltaic (PV) module materials and design on PbSn eutectic solder joint thermal fatigue durability. The statistical method of Latin Hypercube sampling was employed to investigate the sensitivity of simulated damage to each input variable. Variables of laminate material properties and their thicknesses were investigated. Using analysis of variance, we determined that the rate of solder fatigue was most sensitive to solder layer thickness, with copper ribbon and silicon thickness being the next two most sensitive variables. By simulating both accelerated thermal cycles (ATCs) and PV cell temperature histories through two characteristic days of service, we determined that the acceleration factor between the ATC and outdoor service was independent of the variables sampled in this study. This result implies that an ATC test will represent a similar time of outdoor exposure for a wide range of module designs. This is an encouraging result for the standard ATC that must be universally applied across all modules.

  9. Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs

    DEFF Research Database (Denmark)

    Giha, Hayder A; ElGhazali, Gehad; Nasr, Amre

    2010-01-01

    In malaria, drug resistance and treatment failure (TF) are not synonymous, although are escalating together. Over 9 years of surveillances for malaria morbidity and TF in Daraweesh village in eastern Sudan (1991-2004), 136 donors (15-78 years) from 43 households, treated for 278 malaria episodes...

  10. Magnetic field shielding effect for CFETR TF coil-case

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Weiwei; Liu, Xufeng, E-mail: Lxf@ipp.ac.cn; Du, Shuangsong; Zheng, Jinxing

    2017-05-15

    Highlights: • The eddy current of CFETR vacuum vessel can be calculated by using a series of ideal current loops. • The shielding effect with different eddy current is studied by decomposing the exciting magnetic field as two orthogonal components. • The shielding effect can be determined from the rate of eddy current magnetic field to the external magnetic field. - Abstract: The operation of superconducting magnet for fusion device is under the complex magnetic field condition, which affect the stabilization of superconductor. The coil-case of TF coil can shield the magnetic field to some extent. The shielding effect is related to the eddy current of coil-case. The shielding effect with different eddy current is studied by decomposing the exciting magnetic field as two orthogonal components, respectively. The results indicate that the shielding effect of CFETR TF coil-case has obvious different with the different directional magnetic field, and it’s larger for tangential magnetic compared with that for normal field.

  11. Identifying TF-MiRNA Regulatory Relationships Using Multiple Features.

    Directory of Open Access Journals (Sweden)

    Mingyu Shao

    Full Text Available MicroRNAs are known to play important roles in the transcriptional and post-transcriptional regulation of gene expression. While intensive research has been conducted to identify miRNAs and their target genes in various genomes, there is only limited knowledge about how microRNAs are regulated. In this study, we construct a pipeline that can infer the regulatory relationships between transcription factors and microRNAs from ChIP-Seq data with high confidence. In particular, after identifying candidate peaks from ChIP-Seq data, we formulate the inference as a PU learning (learning from only positive and unlabeled examples problem. Multiple features including the statistical significance of the peaks, the location of the peaks, the transcription factor binding site motifs, and the evolutionary conservation are derived from peaks for training and prediction. To further improve the accuracy of our inference, we also apply a mean reciprocal rank (MRR-based method to the candidate peaks. We apply our pipeline to infer TF-miRNA regulatory relationships in mouse embryonic stem cells. The experimental results show that our approach provides very specific findings of TF-miRNA regulatory relationships.

  12. EVALUATION OF TEMPOROMANDIBULAR-JOINT PROSTHESES - REVIEW OF THE LITERATURE FROM 1946 TO 1994 AND IMPLICATIONS FOR FUTURE PROSTHESIS DESIGNS

    NARCIS (Netherlands)

    VANLOON, JP; DEBONT, LGM; BOERING, G

    Purpose: This article describes the useful elements of applied temporomandibular joint (TMJ) prostheses and discusses the factors necessary to be addressed in an appropriate TMJ prosthesis design. Materials and Methods: Information about TMJ prostheses was gathered by a literature search, Only

  13. Tokamak Physics EXperiment (TPX): Toroidal field magnet design, development and manufacture. SDRL 46, CPDR review package. Volume 6

    Energy Technology Data Exchange (ETDEWEB)

    Weber, C.M. [Babcock and Wilcox Co., Lynchburg, VA (United States)

    1995-08-18

    This preliminary design reviews the overall design package for the magnet system. It is mostly presented in viewgraphs. The lengthy presentation took up two full days. Sections are given on TF SDD, TF magnet specifications, TF interface definition, drawing tree and design control, winding pack design, manufacturing, coil setup for VPI, TPX TF magnet assembly, TF materials and processes, quality assurance and test requirements, coil verification testing, TPX acceptance tools, and planning tools.

  14. Design of X-joints in Sandwich Structures for Naval Vessels

    DEFF Research Database (Denmark)

    Hayman, Brian; Berggreen, Christian; Lundsgaard-Larsen, Christian

    2007-01-01

    In many naval ships of fibre composite sandwich construction, an X-joint exists where the end bulkhead of the superstructure is attached to the deck, with an internal bulkhead placed in the same vertical plane below the deck. This joint is subjected to alternating tensile and compressive loading...

  15. Analysis and tests of TF magnet insulation samples for the JET upgrade to 4 tesla

    CERN Document Server

    Miele, P; Bettinali, L; Kaye, A; Last, J; Papastergiou, S; Riccardo, V; Visca, E

    2000-01-01

    The JET Toroidal Field (TF) coils were originally designed for operation at 3.4 tesla. In order to upgrade the field to 4 tesla and thus improve the performance of the JET machine, new mechanical tests and analysis were carried out on the insulation of TF coil samples. They are aimed at investigating the mechanical properties and the status of the insulation in order to set allowable stresses and force limits. In particular since the shear stress in the insulation is strongly affected by the shear modulus of elasticity G, it is important to measure this parameter. A method for the measurement of G in glass-resin fibres, the V-notched beam method (Iosipescu method) , was applied. The particular shape of the rectangular Iosipescu V- notched sample and the particular modality of force application produce pure shear stress for a reliable measurement of the G value and of the shear strength of the insulation. The effect of temperature on these mechanical properties was also investigated. Results show higher averag...

  16. Design, Analysis and Testing of a PRSEUS Pressure Cube to Investigate Assembly Joints

    Science.gov (United States)

    Yovanof, Nicolette; Lovejoy, Andrew E.; Baraja, Jaime; Gould, Kevin

    2012-01-01

    Due to its potential to significantly increase fuel efficiency, the current focus of NASA's Environmentally Responsible Aviation Program is the hybrid wing body (HWB) aircraft. Due to the complex load condition that exists in HWB structure, as compared to traditional aircraft configurations, light-weight, cost-effective and manufacturable structural concepts are required to enable the HWB. The Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) concept is one such structural concept. A building block approach for technology development of the PRSEUS concept is being conducted. As part of this approach, a PRSEUS pressure cube was developed as a risk reduction test article to examine a new integral cap joint concept. This paper describes the design, analysis and testing of the PRSEUS pressure cube test article. The pressure cube was required to withstand a 2P, 18.4 psi, overpressure load requirement. The pristine pressure cube was tested to 2.2P with no catastrophic failure. After the addition of barely visible impact damage, the cube was pressure loaded to 48 psi where catastrophic failure occurred, meeting the scale-up requirement. Comparison of pretest and posttest analyses with the cube test response agree well, and indicate that current analysis methods can be used to accurately analyze PRSEUS structure for initial failure response.

  17. Development of manufacturing technology for ITER TF Coil Structure

    Energy Technology Data Exchange (ETDEWEB)

    Sakurai, Takeru, E-mail: sakurai.takeru@jaea.go.jp; Iguchi, Masahide; Nakahira, Masataka; Inagaki, Takashi; Matsui, Kunihiro; Koizumi, Norikiyo

    2016-11-01

    Highlights: • Heavy thick welding (Max. 287 mm) was performed by balance welding. • Figured out Attachment welding deformation including heavy thick welding. • The deformation of Segments welding was suppressed to 1/3 of previous method. • Based on this study, JAEA started actual ITER TF coil structure manufacturing. - Abstract: Japan Atomic Energy Agency (JAEA) performed a trial of A1 Segment manufacturing of Toroidal Field (TF) coil structure, which is a piece with a radius of curvature 3 m with square channel for coil. Even though both-side welding (balance welding) was preferred to one-side welding considering the welding deformation, it could not be applied to the previous trial due to the difficulty of overhead or horizontal welding by machine. Hence, one-side welding with strong restriction jig was applied in the previous trials. In the latest trial, JAEA adopted a manual balance welding with a development of manufacturing technology. As the result of A1 Segment Mainbody welding trial, welding deformation of the Outer Plate and the Side Plate could have been controlled closer to the target value. JAEA also tried Attachments welding, in which Pre-Compression Flange (PCF) and Extension are welded to A1 Segment Mainbody, and a Segments welding trial, which is a weld between A1 Segment and a part of A2 Segment. A2 Segment is a 3 m straight part with square channel for coil. The inclination of A1 Segment and A2 Segment due to the welding was 2.7 mm. By applying balance welding, the deformation by Segments welding was suppressed to about 1/3 of the one-side welding. The views and opinions expressed herein do not necessarily reflect those of the ITER Organization.

  18. Generation and functional characterization of the anti-transferrin receptor single-chain antibody-GAL4 (TfRscFv-GAL4 fusion protein

    Directory of Open Access Journals (Sweden)

    Ye Qing

    2012-11-01

    Full Text Available Abstract Background The development of vectors for cell-specific gene delivery is a major goal of gene therapeutic strategies. Transferrin receptor (TfR is an endocytic receptor and identified as tumor relative specific due to its overexpression on most tumor cells or tissues, and TfR binds and intakes of transferrin-iron complex. We have previously generated an anti-TfR single-chain variable fragments of immunoglobulin (scFv which were cloned from hybridoma cell line producing antibody against TfR linked with a 20 aa-long linker sequence (G4S4. In the present study, the anti-TfR single-chain antibody (TfRscFv was fused to DNA-binding domain of the yeast transcription factor GAL4. The recombinant fusion protein, designated as TfRscFv-GAL4, is expected to mediate the entry of DNA-protein complex into targeted tumor cells. Results Fusion protein TfRscFv-GAL4 was expressed in an E. coli bacterial expression system and was recovered from inclusion bodies with subsequent purification by metal-chelate chromatography. The resulting proteins were predominantly monomeric and, upon refolding, became a soluble biologically active bifunctional protein. In biological assays, the antigen-binding activity of the re-natured protein, TfRscFv-GAL4, was confirmed by specific binding to different cancer cells and tumor tissues. The cell binding rates, as indicated by flow cytometry (FCM analysis, ranged from 54.11% to 8.23% in seven different human carcinoma cell lines. It showed similar affinity and binding potency as those of parent full-length mouse anti-TfR antibody. The positive binding rates to tumor tissues by tissue microarrays (TMA assays were 75.32% and 63.25%, but it showed weakly binding with hepatic tissue in 5 cases, and normal tissues such as heart, spleen, adrenal cortex blood vessel and stomach. In addition, the re-natured fusion protein TfRscFv-GAL4 was used in an ELISA with rabbit anti-GAL4 antibody. The GAL4-DNA functional assay through the GAL4

  19. Design and evaluation of a quasi-passive knee exoskeleton for investigation of motor adaptation in lower extremity joints.

    Science.gov (United States)

    Shamaei, Kamran; Cenciarini, Massimo; Adams, Albert A; Gregorczyk, Karen N; Schiffman, Jeffrey M; Dollar, Aaron M

    2014-06-01

    In this study, we describe the mechanical design and control scheme of a quasi-passive knee exoskeleton intended to investigate the biomechanical behavior of the knee joint during interaction with externally applied impedances. As the human knee behaves much like a linear spring during the stance phase of normal walking gait, the exoskeleton implements a spring across the knee in the weight acceptance (WA) phase of the gait while allowing free motion throughout the rest of the gait cycle, accomplished via an electromechanical clutch. The stiffness of the device is able to be varied by swapping springs, and the timing of engagement/disengagement changed to accommodate different loading profiles. After describing the design and control, we validate the mechanical performance and reliability of the exoskeleton through cyclic testing on a mechanical knee simulator. We then describe a preliminary experiment on three healthy adults to evaluate the functionality of the device on both left and right legs. The kinetic and kinematic analyses of these subjects show that the exoskeleton assistance can partially/fully replace the function of the knee joint and obtain nearly invariant moment and angle profiles for the hip and ankle joints, and the overall knee joint and exoskeleton complex under the applied moments of the exoskeleton versus the control condition, implying that the subjects undergo a considerable amount of motor adaptation in their lower extremities to the exoskeletal impedances, and encouraging more in-depth future experiments with the device.

  20. Experimental evaluation of the buckling phenomena in the new joint design for upper deck structure of a bridge

    Directory of Open Access Journals (Sweden)

    Solazzi L.

    2010-06-01

    Full Text Available This paper is concerned with the experimental mechanical analysis of a new design of a joint for a main components of a upper deck of a road bridge. These components are subject to the compression state stress induced by the weight and the load acting on the road. Each upper deck of a bridge (positioned on each side of the bridge is composed by four tubular structures that must be joint each together. The joint must to take in to account many aspects, for example that the length of each component is not the same (because, obviously, there is a mechanical tolerance. This phenomena induce different compression stress on each component and so is very important non only the critical buckling load but also the post buckling behaviour of the structure. It is very important that if a single tubular structure reaches the critical load of instability, it still has load capacity . This is to avoid that, in the case where a column reaches the instability, the entire load acting on a column increase the load on the remaining three. For this purpose many different geometrical solutions have been designed (elaborated by fem analyses and successively tested experimentally. This work reports the main experimental results on the best joint solution and how this increase the load capacity and the displacement respect to the solution without this flange.

  1. Adaptive Backstepping Controller Design for Leveling Control of an Underwater Platform Based on Joint Space

    Directory of Open Access Journals (Sweden)

    Zhi-Lin Zeng

    2014-01-01

    Full Text Available This paper focuses on high precision leveling control of an underwater heavy load platform, which is viewed as an underwater parallel robot on the basis of its work pattern. The kinematic of platform with deformation is analyzed and the dynamics model of joint space is established. An adaptive backstepping controller according to Lyapunov's function is proposed for leveling control of platform based on joint space. Furthermore, the “lowest point fixed angle error” leveling scheme called “chase” is chosen for leveling control of platform. The digital simulation and practical experiment of single joint space actuator are carried out, and the results show high precision servo control of joint space. On the basis of this, the platform leveling control simulation relies on the hardware-in-loop system. The results indicate that the proposed controller can effectively restrain the influence from system parameter uncertainties and external disturbance to realize high precision leveling control of the underwater platform.

  2. Design of Experiment and Analysis for the Joint Dynamic Allocation of Fires and Sensors (JDAFS) Simulation

    National Research Council Canada - National Science Library

    Freye, Jeffrey T

    2007-01-01

    ...) model, a low-resolution, Discrete Event Simulation Model with embedded optimization enables the analysis of many scenarios and factors to explore Joint Intelligence, Surveillance, and Reconnaissance (ISR) missions...

  3. Towards a consistent design approach for steel joints under generalized loading

    OpenAIRE

    Silva, L. Simões da

    2008-01-01

    The behaviour of steel joints is complex and requires the proper consideration of a multitude of phenomena, ranging from material non-linearity (plasticity, strain-hardening), non-linear contact and slip, geometrical non-linearity (local instability) to residual stress conditions, and complicated geometrical configurations. The component method is widely accepted as the practical approach in predicting the behaviour of steel joints and it provides detailed procedures to evaluate the strength ...

  4. Quench characterization and thermo hydraulic analysis of SST-1 TF magnet busbar

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, A.N., E-mail: ansharma@ipr.res.in [Institute for Plasma Research, Gandhinagar (India); Pradhan, S. [Institute for Plasma Research, Gandhinagar (India); Duchateau, J.L. [CEA Cadarache, 13108 St Paul lez Durance Cedex (France); Khristi, Y.; Prasad, U.; Doshi, K.; Varmora, P.; Tanna, V.L.; Patel, D.; Panchal, A. [Institute for Plasma Research, Gandhinagar (India)

    2015-01-15

    Highlights: • Details of SST-1 TF busbar quench detection. • Simulation of slow propagating normal zone. • Thermo hydraulic analyses of TF busbar in current feeder system. - Abstract: Toroidal field (TF) magnet system of steady-state superconducting tokamak-1 (SST-1) has 16 superconducting coils. TF coils are cooled with forced flow supercritical helium at 0.4 MPa, at 4.5 K and operate at nominal current of 10,000 A. Prior to TF magnet system assembly in SST-1 tokamak, each TF coil was tested individually in a test cryostat. During these tests, TF coil was connected to a pair of conventional helium vapor cooled current leads. The connecting busbar was made from the same base cable-in-conduit-conductor (CICC) of SST-1 superconducting magnet system. Quenches experimentally observed in the busbar sections of the single coil test setups have been analyzed in this paper. A steady state thermo hydraulic analysis of TF magnet busbar in actual SST-1 tokamak assembly has been done. The experimental observations of quench and results of relevant thermo hydraulic analyses have been used to predict the safe operation regime of TF magnet system busbar during actual SST-1 tokamak operational scenarios.

  5. Impact of mechanism vibration characteristics by joint clearance and optimization design of its multi-objective robustness

    Science.gov (United States)

    Zeng, Baoping; Wang, Chao; Zhang, Yu; Gong, Yajun; Hu, Sanbao

    2017-12-01

    Joint clearances and friction characteristics significantly influence the mechanism vibration characteristics; for example: as for joint clearances, the shaft and bearing of its clearance joint collide to bring about the dynamic normal contact force and tangential coulomb friction force while the mechanism works; thus, the whole system may vibrate; moreover, the mechanism is under contact-impact with impact force constraint from free movement under action of the above dynamic forces; in addition, the mechanism topology structure also changes. The constraint relationship between joints may be established by a repeated complex nonlinear dynamic process (idle stroke - contact-impact - elastic compression - rebound – impact relief - idle stroke movement - contact-impact). Analysis of vibration characteristics of joint parts is still a challenging open task by far. The dynamic equations for any mechanism with clearance is often a set of strong coupling, high-dimensional and complex time-varying nonlinear differential equations which are solved very difficultly. Moreover, complicated chaotic motions very sensitive to initial values in impact and vibration due to clearance let high-precision simulation and prediction of their dynamic behaviors be more difficult; on the other hand, their subsequent wearing necessarily leads to some certain fluctuation of structure clearance parameters, which acts as one primary factor for vibration of the mechanical system. A dynamic model was established to the device for opening the deepwater robot cabin door with joint clearance by utilizing the finite element method and analysis was carried out to its vibration characteristics in this study. Moreover, its response model was carried out by utilizing the DOE method and then the robust optimization design was performed to sizes of the joint clearance and the friction coefficient change range so that the optimization design results may be regarded as reference data for selecting bearings

  6. Fatigue strength: effect of welding type and joint design executed in Ti-6Al-4V structures.

    Science.gov (United States)

    Pantoja, Juliana M C Nuñez; Farina, Ana P; Vaz, Luis G; Consani, Rafael L X; Nóbilo, Mauro A de Arruda; Mesquita, Marcelo F

    2012-06-01

    This study evaluated the fatigue strength of Ti-6Al-4V-machined structures submitted to laser (L)-welding and TIG (TIG)-welding procedures, varying the joint designs. Seventy dumbbell rods were machined in Ti-6Al-4V alloy with central diameters of 3.5 mm. The specimens were sectioned and welded using TIG or L and three joint designs {'I' design, varying welding distances [0.0 mm (I00) or 0.6 mm (I06)], or 'X' [X] design}. The combinations of variables created six groups, which, when added to the intact group, made a total of seven groups (n = 10). L was executed as follows: 360 V/8 ms (X) and 390 V/9 ms (I00 and I06), with focus and frequency regulated to zero. TIG was executed using 2:2 (X) and 3:2 (I00 and I06) as welding parameters. Joints were finished, polished and submitted to radiographic examination to be analysed visually for the presence of porosity. The specimens were then subjected to mechanical cyclic tests, and the number of cycles completed until failure was recorded. The fracture surface was examined using a scanning electron microscope. The Kruskal-Wallis and Dunn test (α = 0.05) indicated that the number of cycles resisted for fracture was higher to X for both welding procedures. To L, I06 was as resistant as X. The Mann-Whitney U-test (α = 0.05) indicated that L joints were more resistant than TIG to I00 and I06. Spearman's correlation coefficient (α = 0.05) indicated a negative correlation between the number of cycles and presence of porosity. Thus, to weld Ti-6Al-4V structures, the best condition is X, independent of the welding method employed. © 2011 The Gerodontology Society and John Wiley & Sons A/S.

  7. Quickly Planning TF/TA2 Trajectory by Artificial Immune Algorithm

    Directory of Open Access Journals (Sweden)

    LIU Lifeng

    2015-04-01

    Full Text Available Flight path planning by artificial immune algorithm approach met the requirements of aircraft's flyability and operation is proposed for the problem of single and double TF/TA2 flight path planning. Punishment function (affinity function with comprehensive 3D threat information is designed. A comprehensive threat model is formed including dynamic and static threats and no-fly-zone. Accordingly, single and dual flight paths are planned by AIA, which have been compared with the paths by GA. The results show that, GA's planned a quick and longer path compared under simple threat environment; in complex environments, GA has high failure rate (greater than 95% for single aircraft, but it is failed for double aircrafts. For the single and double aircrafts, AIA can provides one optimal and more candidate optimal flight paths.

  8. A thermo-hydraulic analysis of the superconducting proposal for the TF magnet system of FAST

    Energy Technology Data Exchange (ETDEWEB)

    Polli, G.M., E-mail: gianmario.polli@enea.it [EURATOM-ENEA, C.R. Frascati, Via E. Fermi, 45, IT-00044 Frascati, Rome (Italy); Corte, A. della; Di Zenobio, A.; Muzzi, L.; Reccia, L.; Turtu, S.; Brolatti, G.; Crisanti, F.; Cucchiaro, A.; Pizzuto, A.; Villari, R. [EURATOM-ENEA, C.R. Frascati, Via E. Fermi, 45, IT-00044 Frascati, Rome (Italy)

    2011-10-15

    FAST (Fusion Advanced Studies Torus), the Italian proposal of a satellite facility to ITER, is a compact tokamak (R{sub 0} = 1.82 m, a = 0.64 m, triangularity {delta} = 0.4) able to investigate non linear dynamics effects of {alpha}-particle behavior in burning plasmas and to test technical solutions for the first wall/divertor directly relevant for ITER and DEMO. Currently, ENEA is investigating the feasibility of a superconducting solution for the magnet system. This paper focuses on the analysis of the TF magnets thermal behavior. In particular, utilizing only the room available in the resistive design and referring to one of the most severe scenario envisaged for FAST, the minimum temperature margin in the coil has been calculated for a thermal load distribution on winding and cable jacket due to nuclear heating only.

  9. Expression of the Thomsen-Friedenreich (TF) tumor antigen in human abort placentas.

    Science.gov (United States)

    Richter, D U; Jeschke, U; Bergemann, C; Makovitzky, J; Lüthen, F; Karsten, U; Briese, V

    2005-01-01

    The Thomsen-Friedenreich antigen (TF), or more precisely epitope, has been known as a pancarcinoma antigen. It consists of galactose-beta1-3-N-acetylgalactose. We have already described the expression of TF in the normal placenta. TF is expressed by the syncytium and by extravillous trophoblast cells. In this study, we investigated the expression of TF in the abort placenta. Frozen samples of human abort placentas (12 placentas), obtained from the first and second trimesters of pregnancy and, for comparison, samples of normal placentas (17 placentas) from the first, second and third trimesters of pregnancy, were used. Expression of TF was investigated by immunohistochemical methods. For identification of TF-positive cells in abort placentas, immunofluorescence methods were used. Evaluation of simple and double immunofluorescence was performed on a laser scanning microscope. Furthermore, we isolated trophoblast cells from first and third trimester placentas and evaluated cytokeratin 7 and Muc1 expression by immunofluorescence methods. We observed expression of TF antigen in the syncytiotrophoblasts layer of the placenta in all three trimesters of pregnancy in normal and abort placentas evaluated by immunohistochemical methods. There was no expression of TF antigen in the decidua of abort placentas. Immunofluorescence double staining of TF antigen and cytokeratin 7 showed reduced expression of both antigens in the abort decidua and co-expression of both antigens in the syncytiotrophoblast layer of normal and abort placentas. TF expression in the syncytiotrophoblast was reduced in abort placentas. In the isolated trophoblast cells, no TF expression was found, however, Muc1 expression was visualized. Expression of TF antigen was reduced in the first and second trimester abort decidua compared to the normal decidua during the same time of pregnancy. TF antigen was restricted to the syncytiotrophoblast and extravillous trophoblast cells in the decidua. Abort placentas

  10. Application of FE-analysis in Design and Verification of Bolted Joints according to VDI 2230 at CERN

    CERN Document Server

    Apeland, Jorgen; Dassa, Luca; Welo, Torgeir

    This thesis investigates how finite element analysis (FEA) can be used to simplify and improve analysis of bolted joints according to the guideline VDI 2230. Some aspects of how FEA can be applied to aid design and verification of bolted joints are given in the guideline, but not in a streamlined way that makes it simple and efficient to apply. The scope of this thesis is to clarify how FEA and VDI 2230 can be combined in analysis of bolted joints, and to present a streamlined workflow. The goal is to lower the threshold for carrying out such combined analysis. The resulting benefits are improved analysis validity and quality, and improved analysis efficiency. A case from the engineering department at CERN, where FEA has been used in analysis of bolted joints is used as basis to identify challenges in combining FEA and VDI 2230. This illustrates the need for a streamlined analysis strategy and well described workflow. The case in question is the Helium vessel (pressure vessel) for the DQW Crab Cavities, whi...

  11. Profile design of loaded pins in composite single lap joints: From circular to non-circular

    Science.gov (United States)

    Zhou, Yadong; Fei, Qingguo; Tao, Jiayue

    Mechanical joints are the weakest links of composite materials and structures. The aim of this study is to investigate the effect of the pin profiles on the stress concentration and load-carry capacity of the pin-loaded single-lap joints subjected to tensile loading. Non-circular profiles of pins are numerically investigated to pursue a possible stress concentration reduction in both the net-tension and bearing stresses of composite single lap joints. Firstly, by varying the characteristic parameters, various round-corner squares are evaluated in terms of peak stresses. Secondly, the square-like profile is transferred to the racetrack-like one in order to gain optimal bearing stresses. Thirdly, the pin of the racetrack-like profile is investigated compared to the circular one, taking into account the through-thickness distributions of stresses. Lastly, the orthotropic effect and the load-carry capacity of the proposed profile are also discussed.

  12. Design of generated axial force measurement tester for tripod constant velocity joints under shudder condition

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwang Hee; Lee, Deuk Won; Chung, Jin Ho; Lee, Chul Hee [Inha University, Incheon (Korea, Republic of); Cho, Won Oh [ChangAm LS, Asan (Korea, Republic of)

    2014-10-15

    Generated axial force (GAF) induced by internal friction in a tripod constant velocity (CV) joint causes shudder, which is related to lateral vibration in a vehicle. GAF is produced by tripod dynamics in the CV joint, and its magnitude is related to an applied torque and articulation angle. GAF provides periodic frictional force, owing to its kinematics, and causes take-off shudder that occurs when a vehicle abruptly accelerates from a stop position. Therefore, accurately estimating the GAF in a CV joint is necessary. A non-rotating type GAF measurement tester is developed to measure GAF more accurately, considering the shudder condition. Results of GAF measurements are compared with those obtained using an existing rotating-type tester. The developed tester provides linear results regardless of test conditions; thus, it can be used to estimate the magnitude of GAF and evaluate the friction performance of grease.

  13. Starting the production of the CEA JT-60SA TF coils at Alstom

    Energy Technology Data Exchange (ETDEWEB)

    Decool, P., E-mail: patrick.decool@cea.fr [CEA, IRFM, F-13108 St-Paul-Lez-Durance Cedex (France); Cloez, H.; Gros, G.; Jiolat, G.; Marechal, J.L.; Nicollet, S.; Torre, A.; Verger, J.M. [CEA, IRFM, F-13108 St-Paul-Lez-Durance Cedex (France); Nusbaum, M.; Billotte, G.; Crepel, B.; Bourquard, A.; Schweitzer, M. [Alstom Power Systems STTG Magnets, 90018 Belfort (France); Davis, S.; Phillips, G. [Fusion for Energy, Boltzmannstr 2, 85748 Garching (Germany)

    2015-10-15

    Highlights: • We describe the status of the JT-60SA TF coils manufacture at Alstom. • The manufacturing workflow and related tooling are described. • Completion of qualification activities has allowed to start the coils production. • Production of the first winding up to its impregnation is described. • Winding of following coils is started. - Abstract: Within the framework of the Broader Approach, the French voluntary contributor represented by CEA awarded a contract for the production of 9 toroidal field coils for the JT-60SA project to Alstom, Belfort, France in mid-2011. A first preparatory phase was led to establish the team, produce the manufacture drawings, define the manufacturing process, procure the required tooling and prepare the quality documentation. In parallel, a qualification phase on the critical major processes has proved Alstom's ability to master the processes and reach the requirements. After reviewing of the qualification results and modification of the processes and tooling to overcome the encountered difficulties, a Production Readiness Review has authorized Alstom to start the production winding. A prototype double pancake was wound as the first of series. In addition to complying with the pancake width all around the D shape, the straightness of the centreline in the critical straight leg part was correct. The production of the successive double pancakes to constitute the first winding pack was then completed and the joints and terminals were manufactured. The paper describes the completion of the last qualifications and the status of the winding production.

  14. A laboratory study on mix design to properly resemble a jointed brittle rock

    Directory of Open Access Journals (Sweden)

    Mostafa Asadizadeh

    2016-12-01

    Full Text Available In this paper attempts have been done to create a mortar with relatively high uniaxial compressive strength (UCS, easy casting, high flexibility, instant hardening, low cost and easy availability. The main use of this material is to physically model the mechanical behavior of jointed rock-like blocks. The effect of four parameters such as joint roughness coefficient (JRC, bridge length (L, bridge angle (γ and joint inclination (θ on UCS of non-persistent jointed blocks were studied. For this purpose, 35 cylindrical specimens with a broad range of plaster content (P and cement content (C in different ages were tested. In order to increase the strength of blocky specimens, some retarder and lubricant were used. The results showed that using 3 wt. % (Weight percent lubricant MGAR106 and 0.05 wt. % Retarder decreases water content by 12.5% and increases plaster and cement content of 8.3% and 4.17 % respectively. Consequently, UCS of blocky specimens increased by 284.33%. In order to formulize the effect of P/C content and the age of cylindrical specimens (A on UCS, Multivariate Non-linear Regression (MNR and Bayesian Regularized Artificial Neural Network (BRANN models were deployed. The results showed that BRANN approach can provide more exact predictions of the specimen UCS than MNR model. Moreover, P/C content had more influence on UCS than the specimen age. Finally the UCS tests on blocky specimens indicated that increasing JRC, bridge length and bridge angle increases UCS and it takes its minimum ate joint inclination of 60°. Furthermore, the capability of produced material to model cracking behaviour of jointed blocks was approved.

  15. Identifying Cancer Subtypes from miRNA-TF-mRNA Regulatory Networks and Expression Data.

    Directory of Open Access Journals (Sweden)

    Taosheng Xu

    Full Text Available Identifying cancer subtypes is an important component of the personalised medicine framework. An increasing number of computational methods have been developed to identify cancer subtypes. However, existing methods rarely use information from gene regulatory networks to facilitate the subtype identification. It is widely accepted that gene regulatory networks play crucial roles in understanding the mechanisms of diseases. Different cancer subtypes are likely caused by different regulatory mechanisms. Therefore, there are great opportunities for developing methods that can utilise network information in identifying cancer subtypes.In this paper, we propose a method, weighted similarity network fusion (WSNF, to utilise the information in the complex miRNA-TF-mRNA regulatory network in identifying cancer subtypes. We firstly build the regulatory network where the nodes represent the features, i.e. the microRNAs (miRNAs, transcription factors (TFs and messenger RNAs (mRNAs and the edges indicate the interactions between the features. The interactions are retrieved from various interatomic databases. We then use the network information and the expression data of the miRNAs, TFs and mRNAs to calculate the weight of the features, representing the level of importance of the features. The feature weight is then integrated into a network fusion approach to cluster the samples (patients and thus to identify cancer subtypes. We applied our method to the TCGA breast invasive carcinoma (BRCA and glioblastoma multiforme (GBM datasets. The experimental results show that WSNF performs better than the other commonly used computational methods, and the information from miRNA-TF-mRNA regulatory network contributes to the performance improvement. The WSNF method successfully identified five breast cancer subtypes and three GBM subtypes which show significantly different survival patterns. We observed that the expression patterns of the features in some miRNA-TF

  16. The effect of functional knee brace design and hinge misalignment on lower limb joint mechanics.

    Science.gov (United States)

    Singer, Jonathan C; Lamontagne, Mario

    2008-01-01

    Knee bracing has been shown to alter lower limb joint mechanics, which may protect the anterior cruciate ligament. The effect of brace alignment and brace type, however, remains largely unknown. This study was conducted to determine whether the use of a functional knee brace, the type of brace used or its alignment relative to the knee causes biomechanical alterations to gait. Ten healthy participants took part in two walking conditions (aligned brace and misaligned brace) for two different types of brace (sleeve brace with bilateral hinges and hinge-post-shell). A non-braced condition was included as a baseline measure. Three-dimensional kinematics and force platform data were used to calculate the joint intersegmental forces and net joint moments of the ankle, knee and hip. In comparison to non-braced walking, the shell brace in its aligned position significantly reduced the peak ankle plantarflexor moment. There was a decreased peak knee flexion angle with both the aligned shell and sleeve braces. The shell brace in its aligned position significantly increased peak knee adduction and reduced peak knee internal rotation. In this sample of healthy participants, functional knee bracing failed to alter lower limb mechanics in such a way that would reduce the force transmitted to the anterior cruciate ligament. In addition, although there were brace induced changes in lower limb kinematics with 2cm of distal hinge misalignment, it is unlikely that hinge misalignment of this magnitude is detrimental to an uninjured knee joint during walking.

  17. Design Optimization of Long-Span Cold-Formed Steel Portal Frames Accounting for Effect of Knee Brace Joint Configuration

    Directory of Open Access Journals (Sweden)

    Thanh Duoc Phan

    2017-12-01

    Full Text Available The application of cold-formed steel channel sections for portal frames becomes more popular for industrial and residential purposes. Experimental tests showed that such structures with long-span up to 20 m can be achieved when knee brace joints are included. In this paper, the influence of knee brace configuration on the optimum design of long-span cold-formed steel portal frames is investigated. The cold-formed steel portal frames are designed using Eurocode 3 under ultimate limit states. A novel method in handling design constraints integrated with genetic algorithm is proposed for searching the optimum design of cold-formed steel portal frames. The result showed that the proposed routine for design optimization effectively searched the near global optimum solution with the computational time is approximate 50% faster than methods being popularly used in literature. The optimum configuration for knee brace joint can reduce the section size of rafter and so the lighter frame could be obtained especially for long-span portal frame. The minimum weight of main frame obtained from optimization process is approximate 19.72% lighter than a Benchmark Frame used in the full-scale experimental test.

  18. BMP-7 induces TF expression in human monocytes by increasing F3 transcriptional activity.

    Science.gov (United States)

    Sovershaev, T A; Egorina, E M; Unruh, D; Bogdanov, V Y; Hansen, J B; Sovershaev, M A

    2015-02-01

    Bone morphogenetic protein (BMP)-7, a major regulator of bone metabolism, inhibits ectopic calcification in atherosclerotic plaques. We have recently reported that BMP-7 is also a potent inducer of tissue factor (TF) in human mononuclear cells (MNCs). While nuclear factor kappa beta (NF-kB) and activation protein-1 (AP-1) are the transcription factors essential for inducible expression of human TF gene (F3), the mechanisms responsible for TF induction by BMP-7 are not known. To elucidate the molecular mechanisms governing BMP-7-triggered TF expression in human MNCs. Human blood monocytes were stimulated with BMP-7 and western blotting, qRT-PCR, and flow cytometry studies were carried out to assess F3 expression; promoter studies were also performed using a panel of reporter constructs. Procoagulant TF activity was measured using a validated FXa generation assay. The significance of NF-kB transcriptional activity was verified via pharmacological inhibition. BMP-7 increased TF protein levels, procoagulant activity, surface presentation, and TF mRNA expression. This increase was accompanied by activation of NF-kB as evidenced by reduced IkB-α levels and elevated transcriptional activity of an NF-kB-sensitive reporter in transfected MNCs. Although treatment with BMP-7 also led to a strong phosphorylation of c-Jun, activation of AP-1 alone was not sufficient to induce TF expression: JSH-23, a potent and specific NF-kB inhibitor, completely blocked BMP-7-induced TF expression. We report that BMP-7-dependent activation of TF in human MNCs is mediated via increased activity of NF-kB, leading to enhanced F3 transcription in human MNCs. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Comparison of SPACE and COBRA-TF for the Droplet Field Predictions

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Nam Yee; Choi, Tong Soo; Lee, Jae Il [KEPCO NF, Daejeon (Korea, Republic of)

    2014-10-15

    There are several system codes which have been supposed to be a best-estimate code, such as RELAP5 and TRACE. However, most of them don't treat droplet field explicitly and they solve six conservation equations only for liquid and vapor. On the contrary, the SPACE code solves nine conservation equations including three equations for droplet field and that is the unique feature of SPACE compared to other previous best-estimate codes. In a LBLOCA, especially during the reflood phase, predicting droplet field accurately is very important since the interfacial heat and momentum transfer between droplets and vapor has a significant effect on the core cooling. Information obtained from droplet field equations (amount, velocity, and temperature of droplets) dominates how high the vapor temperature in the core would be and how much droplets would be carried-over to steam generators to make the steam-binding phenomena. Thus validating the droplet field predictions of SPACE is regarded as one of the essential steps of developing a sound LBLOCA evaluation model using the code. However, it is nearly impossible to validate the droplet field predictions of SPACE using experimental data because there are little LBLOCA experiments in which droplet information was directly measured. That is reason why we chose a rather indirect way of validation to compare the droplet field predictions of SPACE to those of COBRA-TF. COBRA-TF is the only best-estimate code having droplet field equations which has been used for long time for many nuclear applications. This code represents a two-fluid, three-field (continuous liquid, continuous vapor and entrained liquid drop) representation of two-phase flow. In this study, SPACE and COBRA-TF were assessed against the same reflood experiment, and their droplet field predictions were analyzed. The Rod Bundle Heat Transfer (RBHT) experiment is selected for the assessment of SPACE and COBRA-TF. This experiment was conducted by PSU in 2000 supported

  20. Ideal Compliant Joints and Integration of Computer Aided Design and Analysis

    Science.gov (United States)

    2013-11-17

    many MBS applications ( Vallejo et al., 2003; Hamed et al, 2011; Shabana et al, 2012). This can be achieved using ANCF finite elements which allow for...mechanical joints between finite elements can be formulated using linear connectivity conditions ( Vallejo et al., 2003; Hamed et al, 2011; Shabana...function of the damping stress dσ and the strain rate ε as ( Vallejo et al, 2005)  V dd dVP 2 1 T εσ

  1. Design of Joint Spatial and Power Domain Multiplexing Scheme for Massive MIMO Systems

    Directory of Open Access Journals (Sweden)

    Zheng Jiang

    2015-01-01

    Full Text Available Massive Multiple-Input Multiple-Output (MIMO is one of the key techniques in 5th generation wireless systems (5G due to its potential ability to improve spectral efficiency. Most of the existing works on massive MIMO only consider Time Division Duplex (TDD operation that relies on channel reciprocity between uplink and downlink channels. For Frequency Division Duplex (FDD systems, with continued efforts, some downlink multiuser MIMO scheme was recently proposed in order to enable “massive MIMO” gains and simplified system operations with limited number of radio frequency (RF chains in FDD system. However these schemes, such as Joint Spatial Division and Multiplexing (JSDM scheme and hybrid precoding scheme, only focus on multiuser transmission in spatial domain. Different from most of the existing works, this paper proposes Joint Spatial and Power Multiplexing (JSPM scheme in FDD systems. It extends existing FDD schemes from spatial division and multiplexing to joint spatial and power domain to achieve more multiplexing gain. The user grouping and scheduling scheme of JSPM is studied and the asymptotic expression for the sum capacity is derived as well. Finally, simulations are conducted to illustrate the effectiveness of the proposed scheme.

  2. Identifying biologically interpretable transcription factor knockout targets by jointly analyzing the transcription factor knockout microarray and the ChIP-chip data.

    Science.gov (United States)

    Yang, Tzu-Hsien; Wu, Wei-Sheng

    2012-08-16

    targets outperform the original TF knockout targets across all measures. By jointly analyzing the TFKM and ChIP-chip data, our method can extract the biologically interpretable TF knockout targets by identifying paths (in the TF binding network) from the knocked-out TF to these targets. The identified paths form experimentally testable hypotheses regarding the molecular mechanisms of how a TF may regulate its knockout targets. About seven hundred hypotheses generated by our methods have been experimentally validated in the literature. Our work demonstrates that integrating different data sources is a powerful approach to study complex biological systems.

  3. FVIIa-sTF and Thrombin Inhibitory Activities of Compounds Isolated from Microcystis aeruginosa K-139

    Directory of Open Access Journals (Sweden)

    Andrea Roxanne J. Anas

    2017-08-01

    Full Text Available The rise of bleeding and bleeding complications caused by oral anticoagulant use are serious problems nowadays. Strategies that block the initiation step in blood coagulation involving activated factor VII-tissue factor (fVIIa-TF have been considered. This study explores toxic Microcystis aeruginosa K-139, from Lake Kasumigaura, Ibaraki, Japan, as a promising cyanobacterium for isolation of fVIIa-sTF inhibitors. M. aeruginosa K-139 underwent reversed-phase solid-phase extraction (ODS-SPE from 20% MeOH to MeOH elution with 40%-MeOH increments, which afforded aeruginosin K-139 in the 60% MeOH fraction; micropeptin K-139 and microviridin B in the MeOH fraction. Aeruginosin K-139 displayed an fVIIa-sTF inhibitory activity of ~166 µM, within a 95% confidence interval. Micropeptin K-139 inhibited fVIIa-sTF with EC50 10.62 µM, which was more efficient than thrombin inhibition of EC50 26.94 µM. The thrombin/fVIIa-sTF ratio of 2.54 in micropeptin K-139 is higher than those in 4-amidinophenylmethane sulfonyl fluoride (APMSF and leupeptin, when used as positive controls. This study proves that M. aeruginosa K-139 is a new source of fVIIa-sTF inhibitors. It also opens a new avenue for micropeptin K-139 and related depsipeptides as fVIIa-sTF inhibitors.

  4. FVIIa-sTF and Thrombin Inhibitory Activities of Compounds Isolated from Microcystis aeruginosa K-139.

    Science.gov (United States)

    Anas, Andrea Roxanne J; Mori, Akane; Tone, Mineka; Naruse, Chiaki; Nakajima, Anna; Asukabe, Hirohiko; Takaya, Yoshiaki; Imanishi, Susumu Y; Nishizawa, Tomoyasu; Shirai, Makoto; Harada, Ken-Ichi

    2017-08-30

    The rise of bleeding and bleeding complications caused by oral anticoagulant use are serious problems nowadays. Strategies that block the initiation step in blood coagulation involving activated factor VII-tissue factor (fVIIa-TF) have been considered. This study explores toxic Microcystis aeruginosa K-139, from Lake Kasumigaura, Ibaraki, Japan, as a promising cyanobacterium for isolation of fVIIa-sTF inhibitors. M. aeruginosa K-139 underwent reversed-phase solid-phase extraction (ODS-SPE) from 20% MeOH to MeOH elution with 40%-MeOH increments, which afforded aeruginosin K-139 in the 60% MeOH fraction; micropeptin K-139 and microviridin B in the MeOH fraction. Aeruginosin K-139 displayed an fVIIa-sTF inhibitory activity of ~166 µM, within a 95% confidence interval. Micropeptin K-139 inhibited fVIIa-sTF with EC50 10.62 µM, which was more efficient than thrombin inhibition of EC50 26.94 µM. The thrombin/fVIIa-sTF ratio of 2.54 in micropeptin K-139 is higher than those in 4-amidinophenylmethane sulfonyl fluoride (APMSF) and leupeptin, when used as positive controls. This study proves that M. aeruginosa K-139 is a new source of fVIIa-sTF inhibitors. It also opens a new avenue for micropeptin K-139 and related depsipeptides as fVIIa-sTF inhibitors.

  5. Active functional stiffness of the knee joint during activities of daily living: a parameter for improved design of prosthetic limbs.

    Science.gov (United States)

    Bayram, Hande Argunsah; Chien, Chih-Hao; Davis, Brian L

    2014-12-01

    Exploring knee joint physiological functional stiffness is crucial for improving the design of prosthetic legs that aim to mimic normal gait. This study hypothesizes that knee joint stiffness varies among different activities of daily living, additionally while the knee performs natural movements; the magnitude of the stiffness indicates the degree of energy storage element sufficiency in terms of harvesting/returning energy. This study examined sagittal plane knee moment vs. knee flexion angle curves from 12 able-bodied subjects during activities of daily living. Slopes of these curves were assessed to find the calculated stiffness during the peak energy return and harvest phases so that the activities, which can be performed when the prosthetic knee is supplemented by a spring, were identified. For the energy return and harvest phases, the stiffness varied between 0.006 and 0.046 Nm/kg deg. and 0 and 0.052 Nm/kg deg. respectively. The optimum energy return phase stiffness was 0.024 (SD 0.013) Nm/kg deg. and energy harvest phase stiffness was 0.011 (SD 0.018) Nm/kg deg. Knee joint stiffness varied significantly during activities of daily living, which indicated that a storage unit with a constant stiffness would not be sufficient in providing energy regenerative gait during all activities. However, by controlling the amount and timing of spring compression and release, an energy-regenerative prosthetic knee device could be developed during most of the activities. This study was directed to the development of a complete data set, which determined the torque-angle properties of the healthy knee joint. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. DOE's Effort to Reduce Truck Aerodynamic Drag-Joint Experiments and Computations Lead to Smart Design

    Energy Technology Data Exchange (ETDEWEB)

    McCallen, R; Salari, K; Ortega, J; DeChant, L; Hassan, B; Roy, C; Pointer, W; Browand, F; Hammache, M; Hsu, T; Leonard, A; Rubel, M; Chatalain, P; Englar, R; Ross, J; Satran, D; Heineck, J; Walker, S; Yaste, D; Storms, B

    2004-06-17

    At 70 miles per hour, overcoming aerodynamic drag represents about 65% of the total energy expenditure for a typical heavy truck vehicle. The goal of this US Department of Energy supported consortium is to establish a clear understanding of the drag producing flow phenomena. This is being accomplished through joint experiments and computations, leading to the 'smart' design of drag reducing devices. This paper will describe our objective and approach, provide an overview of our efforts and accomplishments, and discuss our future direction.

  7. Fatigue design of welded joints using the finite element method and the 2007 ASME Div. 2 Master curve

    Directory of Open Access Journals (Sweden)

    G. Nicoletto

    2009-07-01

    Full Text Available Fatigue design of welded structures is primarily based on a nominal stress; hot spot stress methods or local approaches each having several limitations when coupled with finite element modeling. An alternative recent structural stress definition is discussed and implemented in a post-processor. It provides an effective means for the direct coupling of finite element results to the fatigue assessment of welded joints in complex structures. The applications presented in this work confirm the main features of the method: mesh-insensitivity, accurate crack location and life to failure predictions.

  8. Bridges Expansion Joints

    National Research Council Canada - National Science Library

    Sergey W. Kozlachkow

    2012-01-01

    .... The analysis of design features of these types of expansion joints, their advantages and disadvantages, based on operational experience justified the necessity to design constructions, meeting...

  9. Cis-regulatory control of the nuclear receptor Coup-TF gene in the sea urchin Paracentrotus lividus embryo

    National Research Council Canada - National Science Library

    Kalampoki, Lamprini G; Flytzanis, Constantin N

    2014-01-01

    ...). The Paracentrotus lividus Coup-TF gene (PlCoup-TF) is expressed throughout embryonic development preferentially in the oral ectoderm of the gastrula and the ciliary band of the pluteus stage. Two overlapping λ...

  10. Advanced development of the spectrum sciences Model 5005-TF, single-event test fixture

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, M.R.; Browning, J.S. (Sandia National Labs., Albuquerque, NM (USA)); Hughlock, B.W. (Boeing Aerospace and Electronics Co., Seattle, WA (USA)); Lum, G.K. (Lockheed Missiles and Space Co., Sunnyvale, CA (USA)); Tsacoyeanes, W.C. (Draper (Charles Stark) Lab., Inc., Cambridge, MA (USA)); Weeks, M.D. (Spectrum Sciences, Inc., Santa Clara, CA (USA))

    1990-09-01

    This report summarizes the advanced development of the Spectrum Sciences Model 5005-TF, Single-Event Test Fixture. The Model 5005-TF uses a Californium-252 (Cf-252) fission-fragment source to test integrated circuits and other devices for the effects of single-event phenomena. Particle identification methods commonly used in high-energy physics research and nuclear engineering have been incorporated into the Model 5005-TF for estimating the particle charge, mass, and energy parameters. All single-event phenomena observed in a device under test (DUT) are correlated with an identified fission fragment, and its linear energy transfer (LET) and range in the semiconductor material of the DUT.

  11. Inflammatory Macrophage Phenotype in BTBR T+tf/J Mice

    Directory of Open Access Journals (Sweden)

    Paul eAshwood

    2013-09-01

    Full Text Available Although autism is a behaviorally defined disorder, many studies report an association with increased pro-inflammatory cytokine production. Recent characterization of the BTBR T+tf/J (BTBR inbred mouse strain has revealed several behavioral characteristics including social deficits, repetitive behavior, and atypical vocalizations which may be relevant to autism. We therefore hypothesized that asocial BTBR mice, which exhibit autism-like behaviors, may have an inflammatory immune profile similar to that observed in children with autism. The objectives of this study were to characterize the myeloid immune profile of BTBR mice and to explore their associations with autism-relevant behaviors. C57BL/6J (C57 mice and BTBR mice were tested for social interest and repetitive self-grooming behavior. Cytokine production was measured in bone-marrow derived macrophages incubated for 24 hours in either growth media alone, LPS, IL-4/ LPS, or IFNγ/ LPS to ascertain any M1/M2 skewing. After LPS stimulation, BTBR macrophages produced higher levels of IL-6, MCP-1, and MIP-1α and lower IL-10 (p<0.01 that C57 mice, suggesting an exaggerated inflammatory profile. After exposure to IL-4/LPS BTBR macrophages produced less IL-10 than C57 macrophages and more IL-12p40 (p<0.01 suggesting poor M2 polarization. Levels of IL-12(p70 (p<0.05 were higher in BTBR macrophages after IFNγ/LPS stimulation, suggesting enhanced M1 polarization. We further observed a positive correlation between grooming frequency, and production of IL-12(p40, IL-12p70, IL-6, and TNFα (p<0.05 after treatment with IFNγ/LPS across both strains. Collectively, these data suggest that the asocial BTBR mouse strain exhibits a more inflammatory, or M1, macrophage profile in comparison to social C57 strain. We have further demonstrated a relationship between this relative increase in inflammation and repetitive grooming behavior, which may have relevance to repetitive and stereotyped behavior of autism.

  12. Transferrin receptor 2 (TfR2) and HFE mutational analysis in non‐C282Y iron overload: identification of a novel TfR2 mutation

    OpenAIRE

    Mattman, A.; Huntsman, D; Lockitch, G; Langlois, S.; Buskard, N; RALSTON, D.; BUTTERFIELD, Y.; Rodrigues, P; Jones, S.; Porto, G; Marra, M.; Sousa, M; VATCHER, G.

    2002-01-01

    Blood. 2002 Aug 1;100(3):1075-7. Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation. Mattman A, Huntsman D, Lockitch G, Langlois S, Buskard N, Ralston D, Butterfield Y, Rodrigues P, Jones S, Porto G, Marra M, De Sousa M, Vatcher G. SourceGenes, Elements, and Metabolism Program, Children and Women's Hospital of British Columbia, Vancouver, British Columbia, Canada. Abstract Hereditary hemochromatosis (HH...

  13. Bridges Expansion Joints

    OpenAIRE

    Sergey W. Kozlachkow

    2012-01-01

    The survey is concerned with the expansion joints, used in bridge constructions to compensate medium and significant operational linear and spatial displacements between adjacent spans or between bridge span and pier. The analysis of design features of these types of expansion joints, their advantages and disadvantages, based on operational experience justified the necessity to design constructions, meeting the modern demands imposed to expansion joints.

  14. Design of a Slowed-Rotor Compound Helicopter for Future Joint Service Missions

    Science.gov (United States)

    Silva, Christopher; Yeo, Hyeonsoo; Johnson, Wayne R.

    2010-01-01

    A slowed-rotor compound helicopter has been synthesized using the NASA Design and Analysis of Rotorcraft (NDARC) conceptual design software. An overview of the design process and the capabilities of NDARC are presented. The benefits of trading rotor speed, wing-rotor lift share, and trim strategies are presented for an example set of sizing conditions and missions.

  15. Identification, modification, and implementation of an evidence-based psychotherapy for children in a low-income country: the use of TF-CBT in Zambia.

    Science.gov (United States)

    Murray, Laura K; Dorsey, Shannon; Skavenski, Stephanie; Kasoma, Margaret; Imasiku, Mwiya; Bolton, Paul; Bass, Judith; Cohen, Judith A

    2013-10-23

    The need to address the treatment gap in mental health services in low- and middle-income countries (LMIC) is well recognized and particularly neglected among children and adolescents. Recent literature with adult populations suggests that evidence-based mental health treatments are effective, feasible, and cross-culturally modifiable for use in LMIC. This paper addresses a gap in the literature documenting pre-trial processes. We describe the process of selecting an intervention to meet the needs of a particular population and the process of cross-cultural adaptation. Community-based participatory research principles were implemented for intervention selection, including joint meetings with stakeholders, review of qualitative research, and review of the literature. Trauma-focused Cognitive Behavioral Therapy (TF-CBT) was chosen as the evidence-based practice for modification and feasibility testing. The TF-CBT adaptation process, rooted within an apprenticeship model of training and supervision, is presented. Clinical case notes were reviewed to document modifications. Choosing an intervention can work as a collaborative process with community involvement. Results also show that modifications were focused primarily on implementation techniques rather than changes in TF-CBT core elements. Studies documenting implementation processes are critical to understanding why intervention choices are made and how the adaptations are generated in global mental health. More articles are needed on how to implement evidence-based treatments in LMIC.

  16. Data of evolutionary structure change: 1YDVA-2V0TF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1YDVA-2V0TF 1YDV 2V0T A F --RKYFVAANWKCNGTLESIKSLTNSFNNLDFDPSKLDV...SGAFTGEVSLPILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVW-------LTPQQAQEAHALIRSWVSSKIGADVA...ID> 0 1YDV A 1YDVAA 1YDVA VDLID--NFDNV 1YDV A 1YDVA

  17. Calculation of Temperature in Sliding Joint Designed as a Part of Foundation Structure

    Directory of Open Access Journals (Sweden)

    Cajka Radim

    2014-06-01

    Full Text Available In case of expected horizontal deformation of subsoil or foundation structure it is possible to use rheological asphalt sliding joint to eliminate internal forces caused with friction. Material characteristics of asphalt are temperature sensitive. In science literature it is possible to find data with temperatures expected in footing bottom, however it was decided to complement this information with temperatures measured in-situ in foundation slab for super-computer building in campus of VŠB-Technical University of Ostrava. In the paper measured and calculated temperatures are compared for the first days after concreting the foundation structure. Besides the temperature of environment also significant influence of heat of cement hydration are taken into account.

  18. Modulation of COUP-TF expression in a cnidarian by ectopic Wnt signalling and allorecognition.

    Directory of Open Access Journals (Sweden)

    David J Duffy

    Full Text Available BACKGROUND: COUP transcription factors are required for the regulation of gene expression underlying development, differentiation, and homeostasis. They have an evolutionarily conserved function, being a known marker for neurogenesis from cnidarians to vertebrates. A homologue of this gene was shown previously to be a neuronal and nematocyte differentiation marker in Hydra. However, COUP-TFs had not previously been studied in a colonial cnidarian. METHODOLOGY/PRINCIPAL FINDINGS: We cloned a COUP-TF homologue from the colonial marine cnidarian Hydractinia echinata. Expression of the gene was analysed during normal development, allorecognition events and ectopic Wnt activation, using in situ hybridisation and quantitative PCR. During normal Hydractinia development, the gene was first expressed in post-gastrula stages. It was undetectable in larvae, and its mRNA was present again in putative differentiating neurons and nematocytes in post-metamorphic stages. Global activation of canonical Wnt signalling in adult animals resulted in the upregulation of COUP-TF. We also monitored a strong COUP-TF upregulation in stolons undergoing allogeneic interactions. COUP-TF mRNA was most concentrated in the tissues that contacted allogeneic, non-self tissues, and decreased in a gradient away from the contact area. Interestingly, the gene was transiently upregulated during initial contact of self stolons, but dissipated rapidly following self recognition, while in non-self contacts high expression levels were maintained. CONCLUSIONS/SIGNIFICANCE: We conclude that COUP-TF is likely involved in neuronal/nematocyte differentiation in a variety of contexts. This has now been shown to include allorecognition, where COUP-TF is thought to have been co-opted to mediate allorejection by recruiting stinging cells that are the effectors of cytotoxic rejection of allogeneic tissue. Our findings that Wnt activation upregulates COUP-TF expression suggests that Wnts' role in

  19. Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation.

    Science.gov (United States)

    Mattman, Andre; Huntsman, David; Lockitch, Gillian; Langlois, Sylvie; Buskard, Noel; Ralston, Diana; Butterfield, Yaron; Rodrigues, Pedro; Jones, Steven; Porto, Graça; Marra, Marco; De Sousa, Maria; Vatcher, Greg

    2002-08-01

    Hereditary hemochromatosis (HH) is classically associated with a Cys282Tyr (C282Y) mutation of the HFE gene. Non-C282Y HH is a heterogeneous group accounting for 15% of HH in Northern Europe. Pathogenic mutations of the transferrin receptor 2 (TfR2) gene have been identified in 4 Italian pedigrees with the latter syndrome. The goal of this study was to perform a mutational analysis of the TfR2 and HFE genes in a cohort of non-C282Y iron overload patients of mixed ethnic backgrounds. Several sequence variants were identified within the TfR2 gene, including a homozygous missense change in exon 17, c2069 A-->C, which changes a glutamine to a proline residue at position 690. This putative mutation was found in a severely affected Portuguese man and 2 family members with the same genotype. In summary, pathologic TfR2 mutations are present outside of Italy, accounting for a small proportion of non-C282Y HH.

  20. On the construction of experimental designs for a given task by jointly optimizing several quality criteria: Pareto-optimal experimental designs.

    Science.gov (United States)

    Sánchez, M S; Sarabia, L A; Ortiz, M C

    2012-11-19

    Experimental designs for a given task should be selected on the base of the problem being solved and of some criteria that measure their quality. There are several such criteria because there are several aspects to be taken into account when making a choice. The most used criteria are probably the so-called alphabetical optimality criteria (for example, the A-, E-, and D-criteria related to the joint estimation of the coefficients, or the I- and G-criteria related to the prediction variance). Selecting a proper design to solve a problem implies finding a balance among these several criteria that measure the performance of the design in different aspects. Technically this is a problem of multi-criteria optimization, which can be tackled from different views. The approach presented here addresses the problem in its real vector nature, so that ad hoc experimental designs are generated with an algorithm based on evolutionary algorithms to find the Pareto-optimal front. There is not theoretical limit to the number of criteria that can be studied and, contrary to other approaches, no just one experimental design is computed but a set of experimental designs all of them with the property of being Pareto-optimal in the criteria needed by the user. Besides, the use of an evolutionary algorithm makes it possible to search in both continuous and discrete domains and avoid the need of having a set of candidate points, usual in exchange algorithms. Copyright © 2012 Elsevier B.V. All rights reserved.

  1. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.

    Science.gov (United States)

    Mastroberardino, Pier Giorgio; Hoffman, Eric K; Horowitz, Maxx P; Betarbet, Ranjita; Taylor, Georgia; Cheng, Dongmei; Na, Hye Mee; Gutekunst, Claire-Anne; Gearing, Marla; Trojanowski, John Q; Anderson, Marjorie; Chu, Charleen T; Peng, Junmin; Greenamyre, J Timothy

    2009-06-01

    More than 80 years after iron accumulation was initially described in the substantia nigra (SN) of Parkinson's disease (PD) patients, the mechanisms responsible for this phenomenon are still unknown. Similarly, how iron is delivered to its major recipients in the cell - mitochondria and the respiratory complexes - has yet to be elucidated. Here, we report a novel transferrin/transferrin receptor 2 (Tf/TfR2)-mediated iron transport pathway in mitochondria of SN dopamine neurons. We found that TfR2 has a previously uncharacterized mitochondrial targeting sequence that is sufficient to import the protein into these organelles. Importantly, the Tf/TfR2 pathway can deliver Tf bound iron to mitochondria and to the respiratory complex I as well. The pathway is redox-sensitive and oxidation of Tf thiols to disulfides induces release from Tf of highly reactive ferrous iron, which contributes to free radical production. In the rotenone model of PD, Tf accumulates in dopamine neurons, with much of it accumulating in the mitochondria. This is associated with iron deposition in SN, similar to what occurs in PD. In the human SN, TfR2 is also found in mitochondria of dopamine neurons, and in PD there is a dramatic increase of oxidized Tf in SN. Thus, we have discovered a novel mitochondrial iron transport system that goes awry in PD, and which may provide a new target for therapeutic intervention.

  2. Pelvic joint fusion in patients with severe pelvic girdle pain - a prospective single-subject research design study.

    Science.gov (United States)

    Kibsgård, Thomas J; Røise, Olav; Stuge, Britt

    2014-03-15

    The fusion of the pelvic joints in patients with severe pelvic girdle pain (PGP) is a controversial and insufficiently studied procedure. The aims of this study were to evaluate physical function and pain after sacroiliac joint (SIJ) fusion. A single-subject research design study with repeated measurements was conducted; pre-operatively and at 3, 6 and 12 months post-operatively. The outcome measures considered were the Oswestry disability index (ODI), visual analogue scale (VAS), and SF-36. Eight patients with severe PGP received open-accessed unilateral anterior SIJ fusion and fusion of the pubic symphysis. Seven patients reported positive results from the surgery. At 1 year post-operation, significant (p < 0.001) reductions in ODI (54 to 37) and VAS (82 to 57) were reported. The physical functioning, bodily pain, and social functioning scores in the SF-36 were also improved. Positive and significant changes in disability and pain at 1 year after SIJ fusion were observed. Despite these positive results, open accessed anterior fusion of the SIJ was associated with adverse events and complications such as infection and nerve damage.

  3. Pelvic joint fusion in patients with severe pelvic girdle pain – a prospective single-subject research design study

    Science.gov (United States)

    2014-01-01

    Background The fusion of the pelvic joints in patients with severe pelvic girdle pain (PGP) is a controversial and insufficiently studied procedure. The aims of this study were to evaluate physical function and pain after sacroiliac joint (SIJ) fusion. Methods A single-subject research design study with repeated measurements was conducted; pre-operatively and at 3, 6 and 12 months post-operatively. The outcome measures considered were the Oswestry disability index (ODI), visual analogue scale (VAS), and SF-36. Eight patients with severe PGP received open-accessed unilateral anterior SIJ fusion and fusion of the pubic symphysis. Results Seven patients reported positive results from the surgery. At 1 year post-operation, significant (p < 0.001) reductions in ODI (54 to 37) and VAS (82 to 57) were reported. The physical functioning, bodily pain, and social functioning scores in the SF-36 were also improved. Conclusion Positive and significant changes in disability and pain at 1 year after SIJ fusion were observed. Despite these positive results, open accessed anterior fusion of the SIJ was associated with adverse events and complications such as infection and nerve damage. PMID:24629145

  4. Design of Raft Foundations for High-Rise Buildings on Jointed Rock

    Science.gov (United States)

    Justo, J. L.; García-Núñez, J.-C.; Vázquez-Boza, M.; Justo, E.; Durand, P.; Azañón, J. M.

    2014-07-01

    This paper presents calculations of displacements and bending moments in a 2-m-thick reinforced-concrete foundation slab using three-dimensional finite-element software. A preliminary paper was presented by Justo et al. (Rock Mech Rock Eng 43:287-304, 2010). The slab is the base of a tower of 137 m height above foundation, supported on jointed and partly weathered basalt and scoria. Installation of rod extensometers at different depths below foundation allowed comparison between measured displacements and displacements calculated using moduli obtained from rock classification systems and three material models: elastic, Mohr-Coulomb and hardening (H). Although all three material models can provide acceptable results, the H model is preferable when there are unloading processes. Acceptable values of settlement may be achieved with medium meshing and an approximate distribution of loads. The absolute values of negative bending moments (tensions below) increase as the rock mass modulus decreases or when the mesh is refined. The paper stresses the importance of adequately representing the details of the distribution of loads and the necessity for fine meshing to obtain acceptable values of bending moments.

  5. Design and Analysis of Metal-to-Composite Nozzle Extension Joints Project

    Data.gov (United States)

    National Aeronautics and Space Administration — As the operational demands of liquid rocket engines increases, so too does the need for improved design and manufacturing methods for metal-to-composite nozzle...

  6. Determination of the Joint Confidence Region of Optimal Operating Conditions in Robust Design by Bootstrap Technique

    OpenAIRE

    Park, Chanseok

    2012-01-01

    Robust design has been widely recognized as a leading method in reducing variability and improving quality. Most of the engineering statistics literature mainly focuses on finding "point estimates" of the optimum operating conditions for robust design. Various procedures for calculating point estimates of the optimum operating conditions are considered. Although this point estimation procedure is important for continuous quality improvement, the immediate question is "how accurate are these o...

  7. Pacer Comet 4: Automated Jet Engine Testing of a TF33-P100 Pratt & Whitney Engine

    Science.gov (United States)

    Mason, Rex Bolding

    Pacer Comet 4 found its life out of necessity to replace an obsolescent Pacer Comet 3 engine test system at Tinker AFB in Oklahoma City, OK. Pacer Comet 3 (PC3) was created and installed in the early 1980's to test jet engines from a wide range of planes. PC3 had several problems from a maintenance standpoint: contractors designed and installed the system but the contract did not include the OEM data package. Without drawings or design knowledge, fixing the smallest of problems could turn into a multi-day project. In addition to high cost, as the OEM companies of proprietary parts went out of business, it became impossible to find a replacement for a failed part. These issues set the framework for the Pacer Comet 4 (PC4) system. PC4 was created as an organic AF and Department of Defense collaboration to fix the issues with PC3. PC4 provides the customer with a complete data package including multiple drawing sets and data sheets for all parts used, as well as design files for all PCBs created in house. PC4 has a standard to use commercially available off the shelf parts (COTS). The reason for this is sustainability in maintenance. If a part is to fail, it should be able to be purchased from any manufacturer that meets the specs of the original product. No proprietary parts are used, except as directed by the engine's OEM. This thesis will focus on the design and installation of the on-frame data acquisition PC4 system for the Pratt & Whitney TF33-P100A-QEC engine that is currently in use on the E3 Sentry. This thesis will show efficiency improvements for maintenance sustainability (70% cabling reduction) as well as discuss performance improvements in both test and production environments.

  8. Item generation and design testing of a questionnaire to assess degenerative joint disease-associated pain in cats.

    Science.gov (United States)

    Zamprogno, Helia; Hansen, Bernie D; Bondell, Howard D; Sumrell, Andrea Thomson; Simpson, Wendy; Robertson, Ian D; Brown, James; Pease, Anthony P; Roe, Simon C; Hardie, Elizabeth M; Wheeler, Simon J; Lascelles, B Duncan X

    2010-12-01

    To determine the items (question topics) for a subjective instrument to assess degenerative joint disease (DJD)-associated chronic pain in cats and determine the instrument design most appropriate for use by cat owners. 100 randomly selected client-owned cats from 6 months to 20 years old. Cats were evaluated to determine degree of radiographic DJD and signs of pain throughout the skeletal system. Two groups were identified: high DJD pain and low DJD pain. Owner-answered questions about activity and signs of pain were compared between the 2 groups to define items relating to chronic DJD pain. Interviews with 45 cat owners were performed to generate items. Fifty-three cat owners who had not been involved in any other part of the study, 19 veterinarians, and 2 statisticians assessed 6 preliminary instrument designs. 22 cats were selected for each group; 19 important items were identified, resulting in 12 potential items for the instrument; and 3 additional items were identified from owner interviews. Owners and veterinarians selected a 5-point descriptive instrument design over 11-point or visual analogue scale formats. Behaviors relating to activity were substantially different between healthy cats and cats with signs of DJD-associated pain. Fifteen items were identified as being potentially useful, and the preferred instrument design was identified. This information could be used to construct an owner-based questionnaire to assess feline DJD-associated pain. Once validated, such a questionnaire would assist in evaluating potential analgesic treatments for these patients.

  9. Design and Evaluation of a New Type of Knee Orthosis to Align the Mediolateral Angle of the Knee Joint with Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Amir Esrafilian

    2012-01-01

    Full Text Available Background. Osteoarthritis (OA is a disease which influences the performance of the knee joint. Moreover, the force and moments applied on the joint increase in contrast to normal subjects. Various types of knee orthoses have been designed to solve the mentioned problems. However, there are other problems in terms of distal migration during walking and the alignment of the orthosis which cannot be changed following the use of brace. Therefore, the main aim of the research was to design an orthosis to solve the aforementioned problems. Method. A new type of knee orthosis was designed with a modular structure. Two patients with knee OA participated in this research project. The force applied on the foot, moment transmitted through the knee joint, and spatiotemporal gait parameters were measured by use of a motion analysis system. Results. The results of the research showed that the adduction moment applied on the knee joint decreased while subjects walked with the new knee orthosis (P-value < 0.05. Conclusion. The new design of the knee brace can be used as an effective treatment to decrease the loads applied on the knee joint and to improve the alignment whilst walking.

  10. Design, development, and testing of a hybrid in situ testing device for building joint sealant

    Science.gov (United States)

    C. White; N. Embree; C. Buch; R.S. Williams

    2005-01-01

    The testing of sealant samples has been restricted to devices that either focus on fatiguing multiple samples or quantifying the mechanical properties of a single sample. This manuscript describes a device that combines these two instrumental designs: the ability to both fatigue and characterize multiple sealant samples at the same time. This device employs precise...

  11. MR Imaging of Degenerative Cartilage Lesions of the Knee Joint in Floor Layers and Graphic Designers

    DEFF Research Database (Denmark)

    Rytter, Søren; Thomsen, Birthe Lykke; Christensen, Birgitte Schütt

    2016-01-01

    tibiofemoral posterior area, the most strained area during kneeling and 2) the total knee. Presence of lesions was compared in floor layers and graphic designers after adjusting for age, BMI, seniority, knee injuries, and sports activity in logistic regression analyses for correlated data, and investigated...

  12. 'Most advanced, yet acceptable': Typicality and novelty as joint predictors of aesthetic preference in industrial design

    NARCIS (Netherlands)

    Hekkert, P.; Snelders, D.; van Wieringen, P.C.W.

    2003-01-01

    Typicality and novelty have often been shown to be related to aesthetic preference of human artefacts. Since a typical product is rarely new and, conversely, a novel product will not often be designated as typical, the positive effects of both features seem incompatible. In three studies it was

  13. The Joint Effect of Competition and Complexity on Customer Accounting System Design

    DEFF Research Database (Denmark)

    Holm, Morten; Ax, Christian

    The importance of measuring customer profitability has recently been reiterated by the management accounting community. However, the stream of research on the factors influencing customer accounting (CA) design choices is still scarce and inconclusive. This paper addresses how the level...... of complexity and competition firms face influences the degree of Customer Profitability Analysis (CPA) Model sophistication. Applying a path analysis on survey data from 217 firms reveals support for three hypotheses: (i) There is an inverted u-shaped relationship between competition intensity and customer...... service complexity; (ii) There is a direct positive relationship between customer service complexity and CPA model sophistication; (iii) This positive association is stronger when competition is non-price based than when competition is price based. The study hereby contributes to research on CA design...

  14. The Joint Effect of Competition and Complexity on Customer Accounting System Design

    DEFF Research Database (Denmark)

    Holm, Morten; Ax, Christian

    The importance of measuring customer profitability has recently been reiterated by the management accounting community. However, the stream of research on the factors influencing customer accounting (CA) design choices is still scarce and inconclusive. This paper addresses how the level of comple...... in particular as well as the general research stream on environmental factors’ influence on the sophistication and use of management accounting systems across firms....

  15. A Novel Multiscale Design of Interfaces for Polymeric Composites and Bonded Joints using Additive Manufacturing

    Science.gov (United States)

    2016-09-13

    Prabhakar UNIVERSITY OF TEXAS AT EL PASO 500 UNIV ST ADMIN BLDG 209 EL PASO, TX 79968-0001 09/13/2016 Final Report DISTRIBUTION A: Distribution...Assistant Professor, Mechanical Engineering The University of Texas at El Paso 500 West University Ave., A-114, El Paso, Texas 79968-0521 Tel: (915...Keck Center for 3D Innovation at the University of Texas at El Paso. The material used to create interface designs was ABS-M30, which will be

  16. Design and Evaluation of a New Type of Knee Orthosis to Align the Mediolateral Angle of the Knee Joint with Osteoarthritis

    Science.gov (United States)

    Esrafilian, Amir; Karimi, Mohammad Taghi; Eshraghi, Arezoo

    2012-01-01

    Background. Osteoarthritis (OA) is a disease which influences the performance of the knee joint. Moreover, the force and moments applied on the joint increase in contrast to normal subjects. Various types of knee orthoses have been designed to solve the mentioned problems. However, there are other problems in terms of distal migration during walking and the alignment of the orthosis which cannot be changed following the use of brace. Therefore, the main aim of the research was to design an orthosis to solve the aforementioned problems. Method. A new type of knee orthosis was designed with a modular structure. Two patients with knee OA participated in this research project. The force applied on the foot, moment transmitted through the knee joint, and spatiotemporal gait parameters were measured by use of a motion analysis system. Results. The results of the research showed that the adduction moment applied on the knee joint decreased while subjects walked with the new knee orthosis (P-value knee brace can be used as an effective treatment to decrease the loads applied on the knee joint and to improve the alignment whilst walking. PMID:22577565

  17. Managing Joint Production Motivation

    DEFF Research Database (Denmark)

    Lindenberg, Siegwart; Foss, Nicolai Juul

    2011-01-01

    We contribute to the microfoundations of organizational performance by proffering the construct of joint production motivation. Under such motivational conditions individuals see themselves as part of a joint endeavor, each with his or her own roles and responsibilities; generate shared...... representations of actions and tasks; cognitively coordinate cooperation; and choose their own behaviors in terms of joint goals. Using goal-framing theory, we explain how motivation for joint production can be managed by cognitive/symbolic management and organizational design....

  18. The Joint Effect of Competition and Complexity on Customer Accounting System Design

    DEFF Research Database (Denmark)

    Holm, Morten; Ax, Christian

    service complexity; (ii) There is a direct positive relationship between customer service complexity and CPA model sophistication; (iii) This positive association is stronger when competition is non-price based than when competition is price based. The study hereby contributes to research on CA design...... of complexity and competition firms face influences the degree of Customer Profitability Analysis (CPA) Model sophistication. Applying a path analysis on survey data from 217 firms reveals support for three hypotheses: (i) There is an inverted u-shaped relationship between competition intensity and customer...

  19. Joint Feature Extraction and Classifier Design for ECG-Based Biometric Recognition.

    Science.gov (United States)

    Gutta, Sandeep; Cheng, Qi

    2016-03-01

    Traditional biometric recognition systems often utilize physiological traits such as fingerprint, face, iris, etc. Recent years have seen a growing interest in electrocardiogram (ECG)-based biometric recognition techniques, especially in the field of clinical medicine. In existing ECG-based biometric recognition methods, feature extraction and classifier design are usually performed separately. In this paper, a multitask learning approach is proposed, in which feature extraction and classifier design are carried out simultaneously. Weights are assigned to the features within the kernel of each task. We decompose the matrix consisting of all the feature weights into sparse and low-rank components. The sparse component determines the features that are relevant to identify each individual, and the low-rank component determines the common feature subspace that is relevant to identify all the subjects. A fast optimization algorithm is developed, which requires only the first-order information. The performance of the proposed approach is demonstrated through experiments using the MIT-BIH Normal Sinus Rhythm database.

  20. Modification and Actuator Minimization of the Hip Leg Joint in a Bipedal Robot: A Proposed Design

    Directory of Open Access Journals (Sweden)

    Nirmalya Tripathi

    2014-12-01

    Full Text Available In recent times, there have been numeric applications of Biped Robots. In this paper, a proposed upper leg hip design of a biped was developed taking cost reduction and optimization as factors for consideration. The proposed system introduces a novel method which consists of a vibration reduction (VR DC stepper motor, microcontroller, microprocessor and gearing arrangement. The program in the microprocessor is so designed that it gives a fixed number of cycles/steps to the VR DC stepper motor in clockwise and thereafter in anti-clockwise direction. This turning movement can then be transmitted to the gearing system which precisely moves one upper leg when the VR DC stepper motor moves in clockwise direction, while the other upper leg remains static, and vice-versa. It has been observed that this new proposed system may reduce the cost overhead, weight and the energy consumption incurred by working on a single VR DC stepper motor while conventionally two stepper motors are used to give the motion of the two upper legs in a biped.

  1. Design and experimental study of joint torque balance mechanism of seed implantation articulated robot

    Directory of Open Access Journals (Sweden)

    Zhang Yongde

    2015-06-01

    Full Text Available This article discusses several new mechanisms that may be used in prostate cancer seed implant robotics. We have developed relatively simple but effective mathematical models of multi-needle puncture prostate using nonlinear spring–damper model; based on Automatic Dynamic Analysis of Mechanical Systems or dynamics module, displacement simulation for prostate is performed, and simulation results indicate that the multi-needle puncture mechanism could reduce prostate displacement in the y- or z-direction. Then aiming at the limitation of human body structure space and seed implant needle insertion path, a revolute-revolute-translational-type prostate seed implantation robot with three-dimensional transrectal ultrasound navigation is designed. It is noteworthy that drive torque fluctuation is caused by the center of gravity change of revolute-revolute tandem cantilever structure; an elastic balance mechanism is designed to realize the complete balance of cantilever weight. Based on Automatic Dynamic Analysis of Mechanical Systems or dynamics module, static drive torque simulation of 2-revolute tandem cantilever structure is performed. Finally, we manufacture the robot prototype and make verification experiment to the cantilever balancing device, and the experiment results provide evidence that elastic balance mechanism can realize the complete balance of cantilever weight, improve the fluctuation in the amplitude value of driving torque, and increase its operation stationary of seed implantation robot system.

  2. Study on Reduced-Moderation Water Reactor (RMWR) core design. Joint research report (FY1998-1999)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-09-01

    The Reduce-Moderation Water Reactor (RMWR) is a next generation water-cooled reactor aiming at effective utilization of uranium resource, high burn-up and long operation cycle, and plutonium multi-recycle. Japan Atomic Energy Research Institute (JAERI) started a joint research program for conceptual design of RMWR core in collaboration with the Japan Atomic Power Company (JAPC) since 1998. The research area includes the RMWR core conceptual designs, development of analysis methods for rector physics and thermal-hydraulics to design the RMWR cores with higher accuracy and preparation of MOX critical experiment to confirm the feasibility from the reactor physics point of view. The present report describes the results of joint research program 'RMWR core design Phase 1' performed by JAERI and JAPC in FY 1998 and 1999. The results obtained from the joint research program are as follows: Conceptual design study on the RMWR core has been performed. A core concept with a conversion ratio more than about 1 is basically feasible to multiple recycling of plutonium. Investigating core characteristics at the equilibrium, some promising core concepts to satisfy above aims have been established. As for BWR-type concepts with negative void reactivity coefficients, three types of design have been obtained as follows; (1) one feasible to attain high conversion ratio about 1.1, (2) one feasible to attain operation cycle of about 2 years and burn-up of about 60 GWd/t with conversion ratio more than 1 or (3) one in simple design based on the ABWR assembly and without blanket attaining conversion ratio more than 1. And as for PWR-type concepts with negative void reactivity coefficients, two types of design have been obtained as follows; (1) one feasible to attain high conversion ratio about 1.05 by using heavy water as a coolant and (2) one feasible to attain conversion ratio about l by using light water. In the study of nuclear calculation method, a reactor analysis code

  3. Coagulant activity and cellular origin of circulating tissue factor exposing microparticles in cancer patients - two forms of TF-exposing microparticles

    NARCIS (Netherlands)

    Kleinjan, A.; Boing, A. N.; Di Nisio, M.; Twint, D.; Kamphuisen, P. W.; Nanayakkara, P.; Buller, H. R.; Nieuwland, R.

    Background: Because plasma of cancer patients presenting with venous thrombosis contains high numbers of tissue factor (TF)-exposing microparticles (TF-MP1), TF-MP have been causally linked to the occurrence of venous thrombosis in cancer patients. The relationship between numbers of TF-exposing MP

  4. PRA in Design: Increasing Confidence in Pre-Operational Assessments of Risks (Results of a Joint NASA/NRC Workshop)

    Science.gov (United States)

    Youngblood, Robert; Dezfuli, Homayoon; Siu, Nathan

    2010-01-01

    In late 2009, the National Aeronautics and Space Administration (NASA) and the U.S. Nuclear Regulatory Commission (NRC) jointly organized a workshop to discuss technical issues associated with application of risk assessments to early phases of system design. The workshop, which was coordinated by the Idaho National Laboratory, involved invited presentations from a number of PRA experts in the aerospace and nuclear fields and subsequent discussion to address the following questions: (a) What technical issues limit decision-makers' confidence in PRA results, especially at a pre-operational phase of the system life cycle? (b) What is being done to address these issues'? (c) What more can be done ? The workshop resulted in participant observations and suggestions on several technical issues, including the pursuit of non-traditional approaches to risk assessment and the verification and validation of risk models. The workshop participants also identified several important non-technical issues, including risk communication with decision makers, and the integration of PRA into the overall design process.

  5. Application of the rapid prototyping technique to design a customized temporomandibular joint used to treat temporomandibular ankylosis

    Science.gov (United States)

    Chaware, Suresh M.; Bagaria, Vaibhav; Kuthe, Abhay

    2009-01-01

    Anthropometric variations in humans make it difficult to replace a temporomandibular joint (TMJ), successfully using a standard “one-size-fits-all” prosthesis. The case report presents a unique concept of total TMJ replacement with customized and modified TMJ prosthesis, which is cost-effective and provides the best fit for the patient. The process involved in designing and modifications over the existing prosthesis are also described. A 12-year- old female who presented for treatment of left unilateral TMJ ankylosis underwent the surgery for total TMJ replacement. A three-dimensional computed tomography (CT) scan suggested features of bony ankylosis of left TMJ. CT images were converted to a sterolithographic model using CAD software and a rapid prototyping machine. A process of rapid manufacturing was then used to manufacture the customized prosthesis. Postoperative recovery was uneventful, with an improvement in mouth opening of 3.5 cm and painless jaw movements. Three years postsurgery, the patient is pain-free, has a mouth opening of about 4.0 cm and enjoys a normal diet. The postoperative radiographs concur with the excellent clinical results. The use of CAD/CAM technique to design the custom-made prosthesis, using orthopaedically proven structural materials, significantly improves the predictability and success rates of TMJ replacement surgery. PMID:19881026

  6. Whole genome shotgun sequence of Bacillus amyloliquefaciens TF28, a biocontrol entophytic bacterium.

    Science.gov (United States)

    Zhang, Shumei; Jiang, Wei; Li, Jing; Meng, Liqiang; Cao, Xu; Hu, Jihua; Liu, Yushuai; Chen, Jingyu; Sha, Changqing

    2016-01-01

    Bacillus amyloliquefaciens TF28 is a biocontrol endophytic bacterium that is capable of inhibition of a broad range of plant pathogenic fungi. The strain has the potential to be developed into a biocontrol agent for use in agriculture. Here we report the whole-genome shotgun sequence of the strain. The genome size of B. amyloliquefaciens TF28 is 3,987,635 bp which consists of 3754 protein-coding genes, 65 tandem repeat sequences, 47 minisatellite DNA, 2 microsatellite DNA, 63 tRNA, 7rRNA, 6 sRNA, 3 prophage and CRISPR domains.

  7. Effect of a part span variable inlet guide vane on TF34 fan performance

    Science.gov (United States)

    Alvarez, J.; Schneider, P. W.

    1981-01-01

    Experimental aerodynamic and performance data were obtained from a TF34 engine. Part span variable inlet guide vanes mounted in front of the fan on the TF34 engine were tested to demonstrate the feasibility of modulating air flow and thrust for vertical takeoff aircraft systems. The fan was mapped to stall for a range of speeds and variable inlet guide were settings. Modulated fan tip performance and unmodulated hub performance were evaluated with a without an extended fan bypass splitter. The effect of a crosswind distortion screen on performance was also evaluated.

  8. Cis-Regulatory Control of the Nuclear Receptor Coup-TF Gene in the Sea Urchin Paracentrotus lividus Embryo

    OpenAIRE

    Lamprini G Kalampoki; Flytzanis, Constantin N.

    2014-01-01

    Coup-TF, an orphan member of the nuclear receptor super family, has a fundamental role in the development of metazoan embryos. The study of the gene's regulatory circuit in the sea urchin embryo will facilitate the placement of this transcription factor in the well-studied embryonic Gene Regulatory Network (GRN). The Paracentrotus lividus Coup-TF gene (PlCoup-TF) is expressed throughout embryonic development preferentially in the oral ectoderm of the gastrula and the ciliary band of the plute...

  9. Design of a Robotic Ankle Joint for a Microspine-Based Robot

    Science.gov (United States)

    Thatte, Nitish

    2011-01-01

    Successful robotic exploration of near-Earth asteroids necessitates a method of securely anchoring to the surface of these bodies without gravitational assistance. Microspine grip- per arrays that can grasp rock faces are a potential solution to this problem. A key component of a future microspine-based rover will be the ankle used to attach each microspine gripper to the robot. The ankle's purpose is twofold: 1) to allow the gripper to conform to the rock so a higher percentage of microspines attach to the surface, and 2) to neutralize torques that may dislodge the grippers from the wall. Parts were developed using computer aided design and manufactured using a variety of methods including selective laser sintering, CNC milling, and traditional manual machining techniques. Upon completion of the final prototype, the gripper and ankle system was tested to demonstrate robotic engagement and disengagement of the gripper and to determine load bearing ability. The immediate application of this project is to out t the Lemur IIb robot so it can climb and hang from rock walls.

  10. Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis.

    Science.gov (United States)

    Kawabata, Hiroshi; Fleming, Robert E; Gui, Dorina; Moon, Seo Y; Saitoh, Takayuki; O'Kelly, James; Umehara, Yutaka; Wano, Yuji; Said, Jonathan W; Koeffler, H Phillip

    2005-01-01

    Transferrin receptor 2 (TfR2) is a membrane glycoprotein that mediates cellular iron uptake from holotransferrin. Homozygous mutations of this gene cause one form of hereditary hemochromatosis in humans. We recently reported that homozygous TfR2(Y245X) mutant mice, which correspond to the TfR2(Y250X) mutation in humans, showed a phenotype similar to hereditary hemochromatosis. In this study, we further analyzed the phenotype as well as iron-related gene expression in these mice by comparing the TfR2-mutant and wild-type siblings. Northern blot analyses showed that the levels of expression of hepcidin mRNA in the liver were generally lower, whereas those of duodenal DMT1, the main transporter for uptake of dietary iron, were higher in the TfR2-mutant mice as compared to the wild-type siblings. Expression of hepcidin mRNA in the TfR2 mutant mice remained low even after intraperitoneal iron loading. In isolated hepatocytes from both wild-type and TfR2 mutant mice, interleukin-6 and lipopolysaccharide each induced expression of hepcidin mRNA. These results suggest that up-regulation of hepcidin expression by inflammatory stimuli is independent of TfR2 and that TfR2 is upstream of hepcidin in the regulatory pathway of body iron homeostasis.

  11. Characterization of the porcine transferrin gene (TF) and its association with disease severity following an experimental Actinobacillus pleuropneumoniae infection.

    Science.gov (United States)

    Daniłowicz, E; Martinez-Arias, R; Dolf, G; Singh, M; Probst, I; Tümmler, B; Höltig, D; Waldmann, K-H; Gerlach, G-F; Stanke, F; Leeb, T

    2010-08-01

    Transferrin (TF)-mediated provision of iron is essential for a productive infection by many bacterial pathogens, and iron-depletion of TF is a first line defence against bacterial infections. Therefore, the transferrin (TF) gene can be considered a candidate gene for disease resistance. We obtained the complete DNA sequence of the porcine TF gene, which spans 40 kb and contains 17 exons. We identified polymorphisms on a panel of 10 different pig breeds. Comparative intra- and interbreed sequence analysis revealed 62 polymorphisms in the TF gene including one microsatellite. Ten polymorphisms were located in the coding sequence of the TF gene. Four SNPs (c.902A>T, c.980G>A, c.1417A>G, c.1810A>C) were predicted to cause amino acid exchanges (p.Lys301Ile, p.Arg327Lys, p.Lys473Glu, p.Asn604His). We performed association analyses using six selected TF markers and 116 pigs experimentally infected with Actinobacillus pleuropneumoniae serotype 7. The analysis showed breed-specific TF allele frequencies. In German Landrace, we found evidence for a possible association of the severity of A. pleuropneumoniae infection with TF genotypes.

  12. 49 CFR 213.351 - Rail joints.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Rail joints. 213.351 Section 213.351... Rail joints. (a) Each rail joint, insulated joint, and compromise joint shall be of a structurally sound design and dimensions for the rail on which it is applied. (b) If a joint bar is cracked, broken...

  13. Performance assessment and optimization of the ITER toroidal field coil joints

    NARCIS (Netherlands)

    Rolando, G.; Foussat, A.; Knaster, J.; Ilyin, Y.; Nijhuis, Arend

    2013-01-01

    The ITER toroidal field (TF) system features eighteen coils that will provide the magnetic field necessary to confine the plasma. Each winding pack is composed of seven double pancakes (DP) connected through praying hands joints. Shaking hands joints are used to interface the terminals of the

  14. Bridges Expansion Joints

    Directory of Open Access Journals (Sweden)

    Sergey W. Kozlachkow

    2012-05-01

    Full Text Available The survey is concerned with the expansion joints, used in bridge constructions to compensate medium and significant operational linear and spatial displacements between adjacent spans or between bridge span and pier. The analysis of design features of these types of expansion joints, their advantages and disadvantages, based on operational experience justified the necessity to design constructions, meeting the modern demands imposed to expansion joints.

  15. Effects of Neoprene Wrist/Hand Splints on Handwriting for Students with Joint Hypermobility Syndrome: A Single System Design Study

    Science.gov (United States)

    Frohlich, Lauren; Wesley, Alison; Wallen, Margaret; Bundy, Anita

    2012-01-01

    Purpose: Pain associated with hypermobility of wrist and hand joints can contribute to decreased handwriting output. This study examined the effectiveness of a neoprene wrist/hand splint in reducing pain and increasing handwriting speed and endurance for students with joint hypermobility syndrome. Methods: Multiple baseline, single system design…

  16. Path to Zero: Ultra-Efficient Architecture on the NREL Campus: S&TF and Master Planning (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Carlisle, N.

    2012-05-01

    Describe the aspects of NREL's S and TF and Campus Master Planning in terms of how they have influenced ultra-efficient architecture on NREL's campus. Energy goals for the NREL campus are: (1) Understand how buildings uses energy, implement the cost-effective energy and water efficiency retrofits; (2) Use principals of energy efficiency and low energy design to reduce energy demand in all new construction; (3) Operate central plants efficiently; (4) Alternative transportation; (5) Use combined heat and power systems; (6) Use on-site renewables for demonstration and where it is cost-effective; and (7) Buy green power (over the next 25 years) so that 100% of our power will be from renewable sources.

  17. Peringkasan Sentimen Esktraktif di Twitter Menggunakan Hybrid TF-IDF dan Cosine Similarity

    Directory of Open Access Journals (Sweden)

    Devid Haryalesmana Wahid

    2016-07-01

    Full Text Available The using of Twitter by selebrities has become a new trend of impression management strategy. Mining public reaction in social media is a good strategy to obtain feedbacks, but extracting it are not trivial matter. Reads hundred of tweets while determine their sentiment polarity are time consuming. Extractive sentiment summarization machine are needed to address this issue. Previous research generally do not include sentiment information contained in a tweet as weight factor, as a results only general topics of discussion are extracted. This research aimed to do an extractive sentiment summarization on both positive and negative sentiment mentioning Indonesian selebrity, Agnes Monica, by combining SentiStrength, Hybrid TF-IDF, and Cosine Similarity. SentiStrength is used to obtain sentiment strength score and classify tweet as a positive, negative or neutral. The summarization of posisitve and negative sentiment can be done by rank tweets using Hybrid TF-IDF summarization and sentiment strength score as additional weight then removing similar tweet by using Cosine Similarity. The test results showed that the combination of SentiStrength, Hybrid TF-IDF, and Cosine Similarity perform better than using Hybrid TF-IDF only, given an average 60% accuracy and 62% f-measure. This is due to the addition of sentiment score as a weight factor in sentiment summ­ari­zation.

  18. Polymorphism of serum proteins (C3, BF, HP and TF) of six populations in Colombia.

    Science.gov (United States)

    Bernal, J E; Sarmiento, P; Briceno, I; Papiha, S S

    1989-01-01

    Five hundred and eighty-five serum samples from six populations in Colombia (Baranoa, Choco, Uitoto Indians, Subachoque, Pasto and Urban Bogotan) were investigated for four genetic markers. For the HP, C3 and BF systems but not for TF there is a wide range of gene frequency variation and these differences are compared with those in the few previous studies.

  19. 78 FR 39057 - Environmental Impact Statement: T.F. Green Airport, Warwick, Rhode Island

    Science.gov (United States)

    2013-06-28

    ... Federal Aviation Administration Environmental Impact Statement: T.F. Green Airport, Warwick, Rhode Island... Environmental Impact Statement has been prepared for Theodore Francis Green Airport in Warwick, Rhode Island..., Rhode Island. The Re-Evaluation and ROD is available for review during normal business hours at the...

  20. Numerical simulation of a relaxation test designed to fit a quasi-linear viscoelastic model for temporomandibular joint discs.

    Science.gov (United States)

    Commisso, Maria S; Martínez-Reina, Javier; Mayo, Juana; Domínguez, Jaime

    2013-02-01

    The main objectives of this work are: (a) to introduce an algorithm for adjusting the quasi-linear viscoelastic model to fit a material using a stress relaxation test and (b) to validate a protocol for performing such tests in temporomandibular joint discs. This algorithm is intended for fitting the Prony series coefficients and the hyperelastic constants of the quasi-linear viscoelastic model by considering that the relaxation test is performed with an initial ramp loading at a certain rate. This algorithm was validated before being applied to achieve the second objective. Generally, the complete three-dimensional formulation of the quasi-linear viscoelastic model is very complex. Therefore, it is necessary to design an experimental test to ensure a simple stress state, such as uniaxial compression to facilitate obtaining the viscoelastic properties. This work provides some recommendations about the experimental setup, which are important to follow, as an inadequate setup could produce a stress state far from uniaxial, thus, distorting the material constants determined from the experiment. The test considered is a stress relaxation test using unconfined compression performed in cylindrical specimens extracted from temporomandibular joint discs. To validate the experimental protocol, the test was numerically simulated using finite-element modelling. The disc was arbitrarily assigned a set of quasi-linear viscoelastic constants (c1) in the finite-element model. Another set of constants (c2) was obtained by fitting the results of the simulated test with the proposed algorithm. The deviation of constants c2 from constants c1 measures how far the stresses are from the uniaxial state. The effects of the following features of the experimental setup on this deviation have been analysed: (a) the friction coefficient between the compression plates and the specimen (which should be as low as possible); (b) the portion of the specimen glued to the compression plates (smaller

  1. Determination of FVIIa-sTF Inhibitors in Toxic Microcystis Cyanobacteria by LC-MS Technique

    Directory of Open Access Journals (Sweden)

    Andrea Roxanne J. Anas

    2015-12-01

    Full Text Available The blood coagulation cascade involves the human coagulation factors thrombin and an activated factor VII (fVIIa. Thrombin and fVIIa are vitamin-K-dependent clotting factors associated with bleeding, bleeding complications and disorders. Thrombin and fVIIa cause excessive bleeding when treated with vitamin-K antagonists. In this research, we explored different strains of toxic Microcystis aeruginosa and cyanobacteria blooms for the probable fVIIa-soluble Tissue Factor (fVIIa-sTF inhibitors. The algal cells were subjected to acidification, and reverse phase (ODS chromatography-solid phase extraction eluted by water to 100% MeOH with 20%-MeOH increments except for M. aeruginosa NIES-89, from the National Institute for Environmental Studies (NIES, which was eluted with 5%-MeOH increments as an isolation procedure to separate aeruginosins 89A and B from co-eluting microcystins. The 40%–80% MeOH fractions of the cyanobacterial extract are active against fVIIa-sTF. The fVIIa-sTF active fractions from cultured cyanobacteria and cyanobacteria blooms were subjected to liquid chromatography-mass spectrometry (LC-MS. The 60% MeOH fraction of M. aeruginosa K139 exhibited an m/z 603 [M + H]+ attributed to aeruginosin K139, and the 40% MeOH fraction of M. aeruginosa NIES-89 displayed ions with m/z 617 [M − SO3 + H]+ and m/z [M + H]+ 717, which attributed to aeruginosin 89. Aeruginosins 102A/B and 298A/B were also observed from other toxic strains of M. aeruginosa with positive fVIIa-sTF inhibitory activity. The active fractions contained cyanobacterial peptides of the aeruginosin class as fVIIa-sTF inhibitors detected by LC-MS.

  2. Welded repair joints of boiler steels following operation in creep conditions exceeding the design time of operation

    Energy Technology Data Exchange (ETDEWEB)

    Dobrzanski, J.; Paszkowska, H.; Zielinski, A. [Institute for Ferrous Metallurgy, Gliwice (Poland)

    2010-07-01

    The assessment of suitability for further operation for materials and welded repair joints of thick-walled main steam pipeline components, made of steel 14MoV63, as well as steam superheater outlet headers made of steel X20CrMoV121 following operation in creep conditions in time periods considerably longer than the specified calculated time of operation. Strength properties, impact strength and transition temperature into brittle condition, as well as structure condition have been evaluated. On the basis of shortened creep tests, the residual life and disposable residual life of materials and welded joints have been determined. Material properties following operation and those of fabricated circumferential welded repair joints have been compared. The condition of examined components and suitability of the fabricated welded repair joints for further operation have been assessed. (orig.)

  3. A Novel Design for Adjustable Stiffness Artificial Tendon for the Ankle Joint of a Bipedal Robot: Modeling & Simulation

    Directory of Open Access Journals (Sweden)

    Aiman Omer

    2015-12-01

    Full Text Available Bipedal humanoid robots are expected to play a major role in the future. Performing bipedal locomotion requires high energy due to the high torque that needs to be provided by its legs’ joints. Taking the WABIAN-2R as an example, it uses harmonic gears in its joint to increase the torque. However, using such a mechanism increases the weight of the legs and therefore increases energy consumption. Therefore, the idea of developing a mechanism with adjustable stiffness to be connected to the leg joint is introduced here. The proposed mechanism would have the ability to provide passive and active motion. The mechanism would be attached to the ankle pitch joint as an artificial tendon. Using computer simulations, the dynamical performance of the mechanism is analytically evaluated.

  4. Issues in the Design, Modeling, and Manufacture of Multiple Joint Solder Self-Assembled Micro-Electro-Mechanical Systems (MEMS)

    National Research Council Canada - National Science Library

    Kladitis, Paul

    2001-01-01

    .... This work is the first in the world to quantify or address the known entirety of major issues that go into realizing multiple joint solder self-assembled polysilicon surface micromachined MEMS...

  5. The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.

    Science.gov (United States)

    D'Alessio, Flavia; Hentze, Matthias W; Muckenthaler, Martina U

    2012-11-01

    The hereditary hemochromatosis-associated membrane proteins HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone hepcidin. While the genetic interactions are clear, it remains elusive how bone morphogenetic protein co-receptor HJV functions together with HFE and TfR2 to activate hepcidin transcription via the BMP-SMAD signaling pathway. Here, we investigate whether HFE, TfR2, and HJV physically interact on the surface of hepatocytes. We explore protein-protein interactions by glycerol gradient sedimentation assays and co-immunoprecipitation analyses in transfected HuH7 hepatoma-derived cells. Our data demonstrate that HFE and TfR2 bind HJV in a non-competitive manner. Co-immunoprecipitation analyses provide direct experimental evidence that HFE, TfR2, and HJV form a multi-protein membrane complex. Our experiments show that like TfR2, HJV competes with TfR1 for binding to HFE, indicating that the expression of TfR2 and HJV may be critical for iron sensing. We identify residues 120-139 of the TfR2 extra-cellular domain as the critical amino acids required for the binding of both HFE and HJV. Interestingly, RGMA, a central nervous system homolog, can substitute for HJV in the complex and promote hepcidin transcription, implicating RGMA in the local control of hepcidin in the CNS. Taken together, our findings provide a biochemical basis for hepcidin control by HFE, TfR2, and HJV. Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  6. Effect of joint design and welding type on the flexural strength and weld penetration of Ti-6Al-4V alloy bars.

    Science.gov (United States)

    Simamoto Júnior, Paulo Cézar; Resende Novais, Veridiana; Rodrigues Machado, Asbel; Soares, Carlos José; Araújo Raposo, Luís Henrique

    2015-05-01

    Framework longevity is a key factor for the success of complete-arch prostheses and commonly depends on the welding methods. However, no consensus has been reached on the joint design and welding type for improving framework resistance. The purpose of this study was to assess the effect of different joint designs and welding methods with tungsten inert gas (TIG) or laser to join titanium alloy bars (Ti-6Al-4V). Seventy titanium alloy bar specimens were prepared (3.18 mm in diameter × 40.0 mm in length) and divided into 7 groups (n=10): the C-control group consisting of intact specimens without joints and the remaining 6 groups consisting of specimens sectioned perpendicular to the long-axis and rejoined using an I-, X30-, or X45-shaped joint design with TIG welding (TI, TX30, and TX45) or laser welding (LI, LX30, and LX45). The specimens were tested with 3-point bending. The fracture surfaces were first evaluated with stereomicroscopy to measure the weld penetration area and then analyzed with scanning electron microscopy (SEM). The data were statistically analyzed with 2-way ANOVA and the Tukey post hoc test, 1-way ANOVA and the Dunnett test, and the Pearson correlation test (α=.05). Specimens from the X30 and X45 groups showed higher flexural strength (Pwelded area (Pwelding type. TIG welded groups showed significantly higher flexural strength than the laser groups (PTIG welding also resulted in higher welded areas than laser welding for the I-shaped specimens. No significant differences were found for the weld penetration area in the X45 group, either for laser or TIG welding. SEM analysis showed more pores at the fracture surfaces of the laser specimens. Fracture surfaces indicative of regions of increased ductility were detected for the TIG specimens. TIG welding resulted in higher flexural strength for the joined titanium specimens than laser welding. For both welding methods, X30- and X45-shaped joint designs resulted in higher flexural strength and

  7. A goal programming approach for a joint design of macroeconomic and environmental policies: a methodological proposal and an application to the Spanish economy.

    Science.gov (United States)

    André, Francisco J; Cardenete, M Alejandro; Romero, Carlos

    2009-05-01

    The economic policy needs to pay increasingly more attention to the environmental issues, which requires the development of methodologies able to incorporate environmental, as well as macroeconomic, goals in the design of public policies. Starting from this observation, this article proposes a methodology based upon a Simonian satisficing logic made operational with the help of goal programming (GP) models, to address the joint design of macroeconomic and environmental policies. The methodology is applied to the Spanish economy, where a joint policy is elicited, taking into consideration macroeconomic goals (economic growth, inflation, unemployment, public deficit) and environmental goals (CO(2), NO( x ) and SO( x ) emissions) within the context of a computable general equilibrium model. The results show how the government can "fine-tune" its policy according to different criteria using GP models. The resulting policies aggregate the environmental and the economic goals in different ways: maximum aggregate performance, maximum balance and a lexicographic hierarchy of the goals.

  8. Factors Associated with Clinician Participation in TF-CBT Post-workshop Training Components.

    Science.gov (United States)

    Pemberton, Joy R; Conners-Burrow, Nicola A; Sigel, Benjamin A; Sievers, Chad M; Stokes, Lauren D; Kramer, Teresa L

    2017-07-01

    For proficiency in an evidence-based treatment (EBT), mental health professionals (MHPs) need training activities extending beyond a one-time workshop. Using data from 178 MHPs participating in a statewide TF-CBT dissemination project, we used five variables assessed at the workshop, via multiple and logistic regression, to predict participation in three post-workshop training components. Perceived in-workshop learning and client-treatment mismatch were predictive of consultation call participation and case presentation respectively. Attitudes toward EBTs were predictive of trauma assessment utilization, although only with non-call participants removed from analysis. Productivity requirements and confidence in TF-CBT skills were not associated with participation in post-workshop activities.

  9. Mutation in Torenia fournieri Lind. UFO homolog confers loss of TfLFY interaction and results in a petal to sepal transformation.

    Science.gov (United States)

    Sasaki, Katsutomo; Yamaguchi, Hiroyasu; Aida, Ryutaro; Shikata, Masahito; Abe, Tomoko; Ohtsubo, Norihiro

    2012-09-01

    We identified a Torenia fournieri Lind. mutant (no. 252) that exhibited a sepaloid phenotype in which the second whorls were changed to sepal-like organs. This mutant had no stamens, and the floral organs consisted of sepals and carpels. Although the expression of a torenia class B MADS-box gene, GLOBOSA (TfGLO), was abolished in the 252 mutant, no mutation of TfGLO was found. Among torenia homologs such as APETALA1 (AP1), LEAFY (LFY), and UNUSUAL FLORAL ORGANS (UFO), which regulate expression of class B genes in Arabidopsis, only accumulation of the TfUFO transcript was diminished in the 252 mutant. Furthermore, a missense mutation was found in the coding region of the mutant TfUFO. Intact TfUFO complemented the mutant phenotype whereas mutated TfUFO did not; in addition, the transgenic phenotype of TfUFO-knockdown torenias coincided with the mutant phenotype. Yeast two-hybrid analysis revealed that the mutated TfUFO lost its ability to interact with TfLFY protein. In situ hybridization analysis indicated that the transcripts of TfUFO and TfLFY were partially accumulated in the same region. These results clearly demonstrate that the defect in TfUFO caused the sepaloid phenotype in the 252 mutant due to the loss of interaction with TfLFY. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.

  10. Qualification of the US made conductors for ITER TF magnet system

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N; Hatfield, D; Miller, J; Bruzzone, P; Stepanov, B; Seber, B

    2009-10-08

    The US Domestic Agency (USDA) is one of the six suppliers of the TF conductor for ITER. In order to qualify conductors according to ITER requirements we prepared several lengths of the CICC and short samples for testing in the SULTAN facility in CRPP, Switzerland. We also fully characterized the strands that were used in these SULTAN samples. Fabrication experience and test results are presented and discussed.

  11. BOREAS TF-1 SSA-OA Weekly Tower CH4 and N2O Flux

    Science.gov (United States)

    Thurtell, George; Edwards, Grant; Simpson, George; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-1 team collected various trace gas and energy flux data in its efforts to characterize the temporal energy and gas exchanges that occurred over the SSA-OA site. This data set contains methane (CH4) and nitrous oxide (N2O) fluxes that were measured at the BOREAS SSA-OA site. These fluxes were measured from 16-Apr to 16-Sep-1994. The data were averaged to weekly values and are available in tabular ASCII files.

  12. Large-scale investigation of human TF-miRNA relations based on coexpression profiles.

    Science.gov (United States)

    Chien, Chia-Hung; Chiang-Hsieh, Yi-Fan; Tsou, Ann-Ping; Weng, Shun-Long; Chang, Wen-Chi; Huang, Hsien-Da

    2014-01-01

    Noncoding, endogenous microRNAs (miRNAs) are fairly well known for regulating gene expression rather than protein coding. Dysregulation of miRNA gene, either upregulated or downregulated, may lead to severe diseases or oncogenesis, especially when the miRNA disorder involves significant bioreactions or pathways. Thus, how miRNA genes are transcriptionally regulated has been highlighted as well as target recognition in recent years. In this study, a large-scale investigation of novel cis- and trans-elements was undertaken to further determine TF-miRNA regulatory relations, which are necessary to unravel the transcriptional regulation of miRNA genes. Based on miRNA and annotated gene expression profiles, the term "coTFBS" was introduced to detect common transcription factors and the corresponding binding sites within the promoter regions of each miRNA and its coexpressed annotated genes. The computational pipeline was successfully established to filter redundancy due to short sequence motifs for TFBS pattern search. Eventually, we identified more convinced TF-miRNA regulatory relations for 225 human miRNAs. This valuable information is helpful in understanding miRNA functions and provides knowledge to evaluate the therapeutic potential in clinical research. Once most expression profiles of miRNAs in the latest database are completed, TF candidates of more miRNAs can be explored by this filtering approach in the future.

  13. Prediction of TF target sites based on atomistic models of protein-DNA complexes

    Directory of Open Access Journals (Sweden)

    Collado-Vides Julio

    2008-10-01

    Full Text Available Abstract Background The specific recognition of genomic cis-regulatory elements by transcription factors (TFs plays an essential role in the regulation of coordinated gene expression. Studying the mechanisms determining binding specificity in protein-DNA interactions is thus an important goal. Most current approaches for modeling TF specific recognition rely on the knowledge of large sets of cognate target sites and consider only the information contained in their primary sequence. Results Here we describe a structure-based methodology for predicting sequence motifs starting from the coordinates of a TF-DNA complex. Our algorithm combines information regarding the direct and indirect readout of DNA into an atomistic statistical model, which is used to estimate the interaction potential. We first measure the ability of our method to correctly estimate the binding specificities of eight prokaryotic and eukaryotic TFs that belong to different structural superfamilies. Secondly, the method is applied to two homology models, finding that sampling of interface side-chain rotamers remarkably improves the results. Thirdly, the algorithm is compared with a reference structural method based on contact counts, obtaining comparable predictions for the experimental complexes and more accurate sequence motifs for the homology models. Conclusion Our results demonstrate that atomic-detail structural information can be feasibly used to predict TF binding sites. The computational method presented here is universal and might be applied to other systems involving protein-DNA recognition.

  14. Full scale trials for qualification of the manufacture of the ITER TF coils in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Matsui, Kunihiro, E-mail: matsui.kunihiro@jaea.go.jp; Hemmi, Tsutomu; Kajitani, Hideki; Yamane, Minoru; Mizutani, Takumi; Nakano, Toshihide; Takano, Katsutoshi; Ando, Shinji; Koizumi, Norikiyo

    2016-11-01

    Highlights: • High accuracy conductor winding of 0.1% was achieved in TF coil fabrication. • Conductor elongation due to heat treatment satisfied with the expected value of 0.06% ± 0.02%. • Commissioning of a transfer tooling without adding strain to conductor was completed. • Commissioning of a conductor insulation and CP welding was successfully completed. - Abstract: JAEA performed full-scale trials to qualify and optimize manufacturing procedure of TF coil fabrication prior to series production. In the full-scale trials, conductor winding, heat treatment, conductor transfer, conductor insulation and cover plate (CP) welding trials were performed to resolve some technical issues and to demonstrate the fabrication procedure. The followings are major achievement. (1) High accuracy conductor winding of 0.01%, (2) the evaluation of 0.06% conductor elongation due to heat treatment, (3) conductor transfer in a radial plate (RP) groove with addition strain under 0.1%, (4) conductor insulation without breakage of the insulation tape and (5) flatness of 2 mm of the double pancake (DP) by CP welding. Then JAEA started the 1st TF coil fabrication from March 2014, and has already completed ten conductor windings and heat treatment of nine windings.

  15. A Follow-Up Study from a Multisite, Randomized Controlled Trial for Traumatized Children Receiving TF-CBT.

    Science.gov (United States)

    Jensen, Tine K; Holt, Tonje; Ormhaug, Silje M

    2017-11-01

    Trauma-focused cognitive behavioral therapy (TF-CBT) is the treatment of choice for traumatized youth, however, follow-up studies are scarce, and treatment effects for co-occurring depression show mixed findings. The aims of this study were to examine whether treatment effects of TF-CBT are maintained at 18 month follow-up and whether degree of co-occurring depression influences treatment effects. As rapid improvement in psychological functioning is warranted for youth, we also investigated whether the symptom trajectory was different for TF-CBT compared to therapy as usual (TAU). The sample consisted of 156 youth (M age = 15.05, 79.50% girls) randomly assigned to TF-CBT or TAU. The youth were assessed for posttraumatic stress symptoms (PTSS), depression, anxiety and general mental health symptoms. Mixed effects analyses followed the symptom courses over 5 time points. Youth receiving TF-CBT maintained their symptom improvement at 18 months follow-up with scores below clinical cut-of on all symptom measures. The most depressed youth had also a significant decline in symptoms that were maintained at follow-up. Symptom trajectories differed as the TF-CBT group reported a more rapid symptom reduction compared to the TAU condition. In the TAU condition, participants received 1.5 times the number of treatment sessions compared to the TF-CBT participants. After 18 months the groups were significantly different on general mental health symptoms only. In conclusion, youth receiving TF-CBT experienced more efficient improvement in trauma related symptoms than youth receiving TAU and these improvements were maintained after 18 months. Also youth experiencing serious co-occurring depression benefitted from TF-CBT.

  16. Cis-Regulatory Control of the Nuclear Receptor Coup-TF Gene in the Sea Urchin Paracentrotus lividus Embryo: e109274

    National Research Council Canada - National Science Library

    Lamprini G Kalampoki; Constantin N Flytzanis

    2014-01-01

    ...). The Paracentrotus lividus Coup-TF gene (PlCoup-TF) is expressed throughout embryonic development preferentially in the oral ectoderm of the gastrula and the ciliary band of the pluteus stage. Two overlapping λ...

  17. 49 CFR 213.121 - Rail joints.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Rail joints. 213.121 Section 213.121..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.121 Rail joints. (a) Each rail joint, insulated joint, and compromise joint shall be of a structurally sound design and dimensions for...

  18. Joint application of AI techniques, PRA and disturbance analysis methodology to problems in the maintenance and design of nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Okrent, D.

    1989-03-01

    This final report summarizes the accomplishments of a two year research project entitled Joint Application of Artificial Intelligence Techniques, Probabilistic Risk Analysis, and Disturbance Analysis Methodology to Problems in the Maintenance and Design of Nuclear Power Plants. The objective of this project is to develop and apply appropriate combinations of techniques from artificial intelligence, (AI), reliability and risk analysis and disturbance analysis to well-defined programmatic problems of nuclear power plants. Reactor operations issues were added to those of design and maintenance as the project progressed.

  19. Joint application of AI techniques, PRA and disturbance analysis methodology to problems in the maintenance and design of nuclear power plants. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Okrent, D.

    1989-03-01

    This final report summarizes the accomplishments of a two year research project entitled ``Joint Application of Artificial Intelligence Techniques, Probabilistic Risk Analysis, and Disturbance Analysis Methodology to Problems in the Maintenance and Design of Nuclear Power Plants. The objective of this project is to develop and apply appropriate combinations of techniques from artificial intelligence, (AI), reliability and risk analysis and disturbance analysis to well-defined programmatic problems of nuclear power plants. Reactor operations issues were added to those of design and maintenance as the project progressed.

  20. Geometrical Comparison of Numerical Models Used in the Design and Validation of Mechanically Rolled Tube-Tubesheet Joints

    DEFF Research Database (Denmark)

    Madsen, Søren Bøgelund; Ibsen, Claus Hessler; Gervang, Bo

    2015-01-01

    The focus of this paper is the validation and comparison of simplified numerical models of the mechanical rolling process used in tube to tubesheet joints. The investigated models is an axisymmetric model and planar models with plane strain and stress. There are different pros and cons...

  1. MiTF links Erk1/2 kinase and p21CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells

    Directory of Open Access Journals (Sweden)

    Liu Feng

    2010-08-01

    Full Text Available Abstract As a survival factor for melanocytes lineage cells, MiTF plays multiple roles in development and melanomagenesis. What role MiTF plays in the DNA damage response is currently unknown. In this report we observed that MiTF was phosphorylated at serine 73 after UVC radiation, which was followed by proteasome-mediated degradation. Unlike after c-Kit stimulation, inhibiting p90RSK-1 did not abolish the band shift of MiTF protein, nor did it abolish the UVC-mediated MiTF degradation, suggesting that phosphorylation on serine 73 by Erk1/2 is a key event after UVC. Furthermore, the MiTF-S73A mutant (Serine 73 changed to Alanine via site-directed mutagenesis was unable to degrade and was continuously expressed after UVC exposure. Compared to A375 melanoma cells expressing wild-type MiTF (MiTF-WT, cells expressing MiTF-S73A mutant showed less p21WAF1/CIP1 accumulation and a delayed p21WAF1/CIP1 recovery after UVC. Consequently, cells expressing MiTF-WT showed a temporary G1 arrest after UVC, but cells expressing MiTF-S73A mutant or lack of MiTF expression did not. Finally, cell lines with high levels of MiTF expression showed higher resistance to UVC-induced cell death than those with low-level MiTF. These data suggest that MiTF mediates a survival signal linking Erk1/2 activation and p21WAF1/CIP1 regulation via phosphorylation on serine 73, which facilitates cell cycle arrest. In addition, our data also showed that exposure to different wavelengths of UV light elicited different signal pathways involving MiTF.

  2. Validation Code Trailer COBRA-TF/PARCSv2.7 before a Transient Boron Injection; Validacion del Codigo Acoplado COBRA-TF/PARCSv2.7 ante un Transitorio de Inyeccion de Boro

    Energy Technology Data Exchange (ETDEWEB)

    Abarca, A.; Barrachina, T.; Miro, R.; Verdu, G.

    2013-07-01

    The object of this work is to validate the attached code COBRA-TF/PARCS in a scenario of asymmetric injection of boron in a PWR reactor of three loops. This is intended to check the newly developed model of transport of boron code COBRA-TF and the routines of interpolation of effective section based on the concentration of boron implemented Parcs v2.7, demonstrating its proper functioning and its validity for the analysis of transient in nuclear safety.

  3. [Effects of serum of patients with MODS on TF and PAI-1 secretion of human vascular endothelial cells during CRRT].

    Science.gov (United States)

    Wang, Jian-wen; Peng, You-ming; Liu, Fu-you; Zhang, Hao

    2009-06-01

    To elucidate the effects of serum of patients with multiple organ dysfunction syndrome (MODS) on tissue factor (TF) and Plasminogen activator inhibitor-1 (PAI-1) secretion of human vascular endothelial cells(HUVEC)during continuous renal replacement therapy (CRRT). Sixteen patients who diagnosed MODS involved were divided into two groups randomly, eight patients treated with CRRT without heparin and the others with heparin for 8 hours. The blood was collected from patients at 0 min, 15 min, 60 min, 120 min and 480 min during CRRT. Serum TNF-alpha, IL-1beta were measured by ELISA.TF and PAI-1 secretion of HUVEC stimulated with serum of patients with MODS undergoing CRRT were detected. TF and PAI-1 expression level were assayed by RT-PCR. TF and PAI-1 secretion were significantly increased in HUVEC stimulated with serum of patients with MODS, but the levels were decreased after CRRT. There are significant positive correlation between TF or PAI-1 secretion of HUVEC and corresponding serum TNFalpha level in the group without heparin, the coefficient correlation is 0.902 and 0.939(P0.05)in the group with heparin. Serum of patients with MODS promote the secretion of TF and PAI-1 in HUVEC.The dysfunction of HUVEC induced by serum of patients with MODS may be related to mediators of inflammation. CRRT can clean up the component which injure HEVEC and improve endothelial cell functions.

  4. CardioTF, a database of deconstructing transcriptional circuits in the heart system

    Directory of Open Access Journals (Sweden)

    Yisong Zhen

    2016-08-01

    Full Text Available Background: Information on cardiovascular gene transcription is fragmented and far behind the present requirements of the systems biology field. To create a comprehensive source of data for cardiovascular gene regulation and to facilitate a deeper understanding of genomic data, the CardioTF database was constructed. The purpose of this database is to collate information on cardiovascular transcription factors (TFs, position weight matrices (PWMs, and enhancer sequences discovered using the ChIP-seq method. Methods: The Naïve-Bayes algorithm was used to classify literature and identify all PubMed abstracts on cardiovascular development. The natural language learning tool GNAT was then used to identify corresponding gene names embedded within these abstracts. Local Perl scripts were used to integrate and dump data from public databases into the MariaDB management system (MySQL. In-house R scripts were written to analyze and visualize the results. Results: Known cardiovascular TFs from humans and human homologs from fly, Ciona, zebrafish, frog, chicken, and mouse were identified and deposited in the database. PWMs from Jaspar, hPDI, and UniPROBE databases were deposited in the database and can be retrieved using their corresponding TF names. Gene enhancer regions from various sources of ChIP-seq data were deposited into the database and were able to be visualized by graphical output. Besides biocuration, mouse homologs of the 81 core cardiac TFs were selected using a Naïve-Bayes approach and then by intersecting four independent data sources: RNA profiling, expert annotation, PubMed abstracts and phenotype. Discussion: The CardioTF database can be used as a portal to construct transcriptional network of cardiac development. Availability and Implementation: Database URL: http://www.cardiosignal.org/database/cardiotf.html.

  5. Joint ventures

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    Afhandlingen analysere de konkurrenceretlige og selskabsretlige regler som er bestemmende for hvordan et joint venture samarbejde er struktureret......Afhandlingen analysere de konkurrenceretlige og selskabsretlige regler som er bestemmende for hvordan et joint venture samarbejde er struktureret...

  6. Every Site Counts: Submitting Transcription Factor-Binding Site Information through the CollecTF Portal.

    Science.gov (United States)

    Erill, Ivan

    2015-08-01

    Experimentally verified transcription factor-binding sites represent an information-rich and highly applicable data type that aptly summarizes the results of time-consuming experiments and inference processes. Currently, there is no centralized repository for this type of data, which is routinely embedded in articles and extremely hard to mine. CollecTF provides the first standardized resource for submission and deposition of these data into the NCBI RefSeq database, maximizing its accessibility and prompting the community to adopt direct submission policies. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  7. Design of a stiffness-adjustable ankle-foot orthosis and its effect on ankle joint kinematics in patients with stroke.

    Science.gov (United States)

    Kobayashi, Toshiki; Leung, Aaron K L; Akazawa, Yasushi; Hutchins, Stephen W

    2011-04-01

    Ankle-foot orthoses (AFOs) are commonly prescribed to improve gait. The stiffness of an AFO is central for successful prescription; however, the recommended level of stiffness is currently based on the experience of clinicians. Therefore, the aim of this study was to design an experimental AFO (EAFO) whose stiffness was adjustable using commercially available oil-damper joints, and to demonstrate its potential capability in investigating the effects of altering AFO stiffness on gait. The influence of the EAFO stiffness on ankle joint kinematics in sagittal plane was evaluated in 10 patients with stroke by altering the stiffness of its oil-damper- type orthotic ankle joints using the four levels pre-set and defined by the manufacturer in dorsi- and plantarflexion directions independently. The mean peak plantarflexion angle was reduced by 105%, showing a change from 8.18 (3.14) degrees of plantarflexion to 0.38 (4.17) degrees of dorsiflexion, whilst the mean peak dorsiflexion angle was reduced by 44%, showing a change from 11.46 (5.57) degrees of dorsiflexion to 6.47 (5.23) degrees of dorsiflexion by altering the EAFO stiffness. The EAFO would therefore serve as a convenient tool when investigating the influence of AFO stiffness on gait in both clinical and research settings. Copyright © 2011 Elsevier B.V. All rights reserved.

  8. Investigating cryoinjury using simulations and experiments. 1: TF-1 cells during two-step freezing (rapid cooling interrupted with a hold time).

    Science.gov (United States)

    Ross-Rodriguez, L U; Elliott, J A W; McGann, L E

    2010-08-01

    There is significant interest in designing a cryopreservation protocol for hematopoietic stem cells (HSC) which does not rely on dimethyl sulfoxide (Me(2)SO) as a cryoprotectant. Computer simulations that describe cellular osmotic responses during cooling and warming can be used to optimize the viability of cryopreserved HSC; however, a better understanding of cellular osmotic parameters is required for these simulations. As a model for HSC, the erythroleukemic human cell line TF-1 was used in this study. Simulations, based on the osmotic properties of TF-1 cells and on the solution properties of the intra- and extracellular compartments, were used to interpret cryoinjury associated with a two-step cryopreservation protocol. Calculated intracellular supercooling was used as an indicator of cryoinjury related to intracellular ice formation. Simulations were applied to the two-step cooling protocol (rapid cooling interrupted with a hold time) for TF-1 cells in the absence of Me(2)SO or other cryoprotectants and optimized by minimizing the indicator of cryoinjury. A comparison of simulations and experimental measurements of membrane integrity supports the concept that, for two-step cooling, increasing intracellular supercooling is the primary contributor to potential freezing injury due to the increase in the likelihood of intracellular ice formation. By calculating intracellular supercooling for each step separately and comparing these calculations with cell recovery data, it was demonstrated that it is not optimal simply to limit overall supercooling during two-step freezing procedures. More aptly, appropriate limitations of supercooling differ from the first step to the second step. This study also demonstrates why high cell recovery after cryopreservation could be achieved in the absence of traditional cryoprotectants. (c) 2010 Elsevier Inc. All rights reserved.

  9. Joint Disorders

    Science.gov (United States)

    A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. Joints can be damaged by many types of injuries or diseases, including Arthritis - inflammation of a joint. It causes pain, stiffness, and swelling. Over time, ...

  10. Relaxed Bi - Quadratic Optimization For Joint Filter Signal Design In Signal Dependent Space Time Adaptive Processing (STAP) (Preprint)

    Science.gov (United States)

    2016-11-16

    the following function P(fd, θ) = |wHo (v(fd)⊗ soa (θ, φ)|2. (59) That is, the adapted pattern for a given beamformer-signal pair wo, so is a function...public release; distribution is unlimited. 13. SUPPLEMENTARY NOTES The U.S. Government is joint author of the work and has the right to use, modify...subspace alignment and the overall adapted pattern . 48 Approved for public release; distribution is unlimited. S. M. O’ROURKE, ET AL.: AFRL SENSORS

  11. Validation of Helium Inlet Design for ITER Toroidal Field Coil

    CERN Document Server

    Boyer, C; Hamada, K; Foussat, A; Le Rest, M; Mitchell, N; Decool, P; Savary, F; Sgobba, S; Weiss, K-P

    2014-01-01

    The ITER organization has performed design and its validation tests on a helium inlet structure for the ITER Toroidal Field (TF) coil under collaboration with CERN, KIT, and CEA-Cadarache. Detailed structural analysis was performed in order to optimize the weld shape. A fatigue resistant design on the fillet weld between the shell covers and the jacket is an important point on the helium inlet structure. A weld filler material was selected based on tensile test at liquid helium temperature after Nb3Sn reaction heat treatment. To validate the design of the weld joint, fatigue tests at 7 K were performed using heat-treated butt weld samples. A pressure drop measurement of a helium inlet mock-up was performed by using nitrogen gas at room temperature in order to confirm uniform flow distribution and pressure drop characteristic. These tests have validated the helium inlet design. Based on the validation, Japanese and European Union domestic agencies, which have responsibilities of the TF coil procurement, are pr...

  12. Joint Injection/Aspiration

    Science.gov (United States)

    ... A Patient / Caregiver Treatments Joint Injection / Aspiration Joint Injections (Joint Aspirations) Fast Facts Joint aspiration is used ... is derived from a joint aspiration or joint injection? Joint aspiration usually is done for help with ...

  13. Eukaryotic and archaeal TBP and TFB/TF(II)B follow different promoter DNA bending pathways.

    Science.gov (United States)

    Gietl, Andreas; Holzmeister, Phil; Blombach, Fabian; Schulz, Sarah; von Voithenberg, Lena Voith; Lamb, Don C; Werner, Finn; Tinnefeld, Philip; Grohmann, Dina

    2014-06-01

    During transcription initiation, the promoter DNA is recognized and bent by the basal transcription factor TATA-binding protein (TBP). Subsequent association of transcription factor B (TFB) with the TBP-DNA complex is followed by the recruitment of the ribonucleic acid polymerase resulting in the formation of the pre-initiation complex. TBP and TFB/TF(II)B are highly conserved in structure and function among the eukaryotic-archaeal domain but intriguingly have to operate under vastly different conditions. Employing single-pair fluorescence resonance energy transfer, we monitored DNA bending by eukaryotic and archaeal TBPs in the absence and presence of TFB in real-time. We observed that the lifetime of the TBP-DNA interaction differs significantly between the archaeal and eukaryotic system. We show that the eukaryotic DNA-TBP interaction is characterized by a linear, stepwise bending mechanism with an intermediate state distinguished by a distinct bending angle. TF(II)B specifically stabilizes the fully bent TBP-promoter DNA complex and we identify this step as a regulatory checkpoint. In contrast, the archaeal TBP-DNA interaction is extremely dynamic and TBP from the archaeal organism Sulfolobus acidocaldarius strictly requires TFB for DNA bending. Thus, we demonstrate that transcription initiation follows diverse pathways on the way to the formation of the pre-initiation complex. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. ReagentTF: a rapid and versatile optical clearing method for biological imaging(Conference Presentation)

    Science.gov (United States)

    Yu, Tingting; Zhu, Jingtan; Li, Yusha; Qi, Yisong; Xu, Jianyi; Gong, Hui; Luo, Qingming; Zhu, Dan

    2017-02-01

    The emergence of various optical clearing methods provides a great potential for imaging deep inside tissues by combining with multiple-labelling and microscopic imaging techniques. They were generally developed for specific imaging demand thus presented some non-negligible limitations such as long incubation time, tissue deformation, fluorescence quenching, incompatibility with immunostaining or lipophilic tracers. In this study, we developed a rapid and versatile clearing method, termed ReagentTF, for deep imaging of various fluorescent samples. This method can not only efficiently clear embryos, neonatal whole-brains and adult thick brain sections by simple immersion in aqueous mixtures with minimal volume change, but also can preserve fluorescence of various fluorescent proteins and simultaneously be compatible with immunostaining and lipophilic neuronal dyes. We demonstrate the effectiveness of this method in reconstructing the cell distributions of mouse hippocampus, visualizing the neural projection from CA1 (Cornu Ammonis 1) to HDB (nucleus of the horizontal limb of the diagonal band), and observing the growth of forelimb plexus in whole-mount embryos. These results suggest that ReagentTF is useful for large-volume imaging and will be an option for the deep imaging of biological tissues.

  15. Voc Degradation in TF-VLS Grown InP Solar Cells

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Yubo; Sun, Xingshu; Johnston, Steve; Sutter-Fella, Carolin M.; Hettick, Mark; Javey, Ali; Bermel, Peter

    2016-11-21

    Here we consider two hypotheses to explain the open-circuit voltage (VOC) degradation observed in thin-film vapor-liquid-solid (TF-VLS) grown p-type InP photovoltaic cells: bandgap narrowing and local shunting. First, a bandgap (Eg) narrowing effect is hypothesized, based on the surface inhomogeneity of VLS InP captured by the photoluminescence (PL) image. The PL data was used to estimate a spatially-resolved active VOC across surface of the InP sample. Combining this data with the effective Jsc allowed an assessment of the I-V characteristics of individual unit cells. Next, an H-SPICE diode compact model was utilized to reproduce the I-V characteristics of the whole sample. We find a good fit to the I-V performance of TF-VLS grown InP solar cell. Second, a local shunting effect was also considered as an alternative explanation of the VOC degradation effect. Again, PL image data was used, and small local shunt resistance was added in arbitrary elementary unit cells to represent certain dark spots seen in the PL image and dictate the VOC degradation occurred in the sample.

  16. Strategic Mobility 21 Joint Sea Based Logistics

    National Research Council Canada - National Science Library

    Mallon, Lawrence G

    2008-01-01

    The Joint Deployment and Distribution Support Platform (JDDSP) design concept developed by SM21 includes distribution support for joint sea-based forces in its design and will support many of the to...

  17. Cis-regulatory control of the nuclear receptor Coup-TF gene in the sea urchin Paracentrotus lividus embryo.

    Directory of Open Access Journals (Sweden)

    Lamprini G Kalampoki

    Full Text Available Coup-TF, an orphan member of the nuclear receptor super family, has a fundamental role in the development of metazoan embryos. The study of the gene's regulatory circuit in the sea urchin embryo will facilitate the placement of this transcription factor in the well-studied embryonic Gene Regulatory Network (GRN. The Paracentrotus lividus Coup-TF gene (PlCoup-TF is expressed throughout embryonic development preferentially in the oral ectoderm of the gastrula and the ciliary band of the pluteus stage. Two overlapping λ genomic clones, containing three exons and upstream sequences of PlCoup-TF, were isolated from a genomic library. The transcription initiation site was determined and 5' deletions and individual segments of a 1930 bp upstream region were placed ahead of a GFP reporter cassette and injected into fertilized P.lividus eggs. Module a (-532 to -232, was necessary and sufficient to confer ciliary band expression to the reporter. Comparison of P.lividus and Strongylocentrotus purpuratus upstream Coup-TF sequences, revealed considerable conservation, but none within module a. 5' and internal deletions into module a, defined a smaller region that confers ciliary band specific expression. Putative regulatory cis-acting elements (RE1, RE2 and RE3 within module a, were specifically bound by proteins in sea urchin embryonic nuclear extracts. Site-specific mutagenesis of these elements resulted in loss of reporter activity (RE1 or ectopic expression (RE2, RE3. It is proposed that sea urchin transcription factors, which bind these three regulatory sites, are necessary for spatial and quantitative regulation of the PlCoup-TF gene at pluteus stage sea urchin embryos. These findings lead to the future identification of these factors and to the hierarchical positioning of PlCoup-TF within the embryonic GRN.

  18. Exquisite binding specificity of Sclerotium rolfsii lectin toward TF-related O-linked mucin-type glycans.

    Science.gov (United States)

    Chachadi, Vishwanath B; Inamdar, Shashikala R; Yu, Lu-Gang; Rhodes, Jonathan M; Swamy, Bale M

    2011-01-01

    Sclerotium rolfsii lectin (SRL), a secretory protein from the soil borne phytopathogenic fungus Sclerotium rolfsii, has shown in our previous studies to bind strongly to the oncofetal Thomson-Friedenreich carbohydrate (Galβ1-3GalNAc-ser/thr, T or TF) antigen. TF antigen is widely expressed in many types of human cancers and the strong binding of SRL toward such a cancer-associated carbohydrate structure led us to characterize the carbohydrate binding specificity of SRL. Glycan array analysis, which included 285 glycans, shows exclusive binding of SRL to the O-linked mucin type but not N-linked glycans and amongst the mucin type O-glycans, lectin recognizes only mucin core 1, core 2 and weakly core 8 but not to other mucin core structures. It binds with high specificity to "α-anomers" but not the "β-anomers" of the TF structure. The axial C4-OH group of GalNAc and C2-OH group of Gal is both essential for SRL interaction with TF disaccharide, and substitution on C3 of galactose by sulfate or sialic acid or N-acetylglucosamine, significantly enhances the avidity of the lectin. SRL differs in its binding to TF structures compared to other known TF-binding lectins such as the Arachis hypogea (peanut) agglutinin, Agaricus bisporus (mushroom) lectin, Jackfruit, Artocarpus integrifolia (jacalin) and Amaranthus caudatus (Amaranthin) lectin. Thus, SRL has unique carbohydrate-binding specificity toward TF-related O-linked carbohydrate structures. Such a binding specificity will make this lectin a very useful tool in future structural as well as functional analysis of the cellular glycans in cancer studies.

  19. Cis-regulatory control of the nuclear receptor Coup-TF gene in the sea urchin Paracentrotus lividus embryo.

    Science.gov (United States)

    Kalampoki, Lamprini G; Flytzanis, Constantin N

    2014-01-01

    Coup-TF, an orphan member of the nuclear receptor super family, has a fundamental role in the development of metazoan embryos. The study of the gene's regulatory circuit in the sea urchin embryo will facilitate the placement of this transcription factor in the well-studied embryonic Gene Regulatory Network (GRN). The Paracentrotus lividus Coup-TF gene (PlCoup-TF) is expressed throughout embryonic development preferentially in the oral ectoderm of the gastrula and the ciliary band of the pluteus stage. Two overlapping λ genomic clones, containing three exons and upstream sequences of PlCoup-TF, were isolated from a genomic library. The transcription initiation site was determined and 5' deletions and individual segments of a 1930 bp upstream region were placed ahead of a GFP reporter cassette and injected into fertilized P.lividus eggs. Module a (-532 to -232), was necessary and sufficient to confer ciliary band expression to the reporter. Comparison of P.lividus and Strongylocentrotus purpuratus upstream Coup-TF sequences, revealed considerable conservation, but none within module a. 5' and internal deletions into module a, defined a smaller region that confers ciliary band specific expression. Putative regulatory cis-acting elements (RE1, RE2 and RE3) within module a, were specifically bound by proteins in sea urchin embryonic nuclear extracts. Site-specific mutagenesis of these elements resulted in loss of reporter activity (RE1) or ectopic expression (RE2, RE3). It is proposed that sea urchin transcription factors, which bind these three regulatory sites, are necessary for spatial and quantitative regulation of the PlCoup-TF gene at pluteus stage sea urchin embryos. These findings lead to the future identification of these factors and to the hierarchical positioning of PlCoup-TF within the embryonic GRN.

  20. 2D thermal analysis for heat transfer from casing to winding pack in JT-60SA TF coils

    Energy Technology Data Exchange (ETDEWEB)

    Polli, G.M. [Association EURATOM-ENEA, C.R. Frascati, Via E. Fermi, 45, IT-00044 Frascati (Italy)], E-mail: polli@frascati.enea.it; Reccia, L.; Cucchiaro, A.; Della Corte, A.; Di Zenobio, A.; Muzzi, L.; Pizzuto, A.; Ramogida, G.; Turtu, S.; Villari, R. [Association EURATOM-ENEA, C.R. Frascati, Via E. Fermi, 45, IT-00044 Frascati, RM (Italy); Nannini, M.; Portafaix, C.; Zani, L. [Association EURATOM-CEA, DRFC, F-13108 Saint Paul lez Durance (France); Barabaschi, P. [JT-60SA European Home Team, 85748 Garching (Germany)

    2009-06-15

    In the framework of the Broader Approach Agreement, Europe is involved in the design activities for the Japanese Tokamak JT-60SA, investigating, among several issues, the operation of the superconducting TF magnets and their subsystems, aimed at the reactor conceptual design definition. In particular, one of the main critical aspects to study is the heating of the conductor due to both direct component of energy deposited by neutrons and by secondary gamma generated during plasma operation, and heat generated by the radiation on casing and transferred to the winding pack. Indeed, the operating temperature and the relevant temperature margin (i.e. the operating safety margin) of the magnet will depend strongly on the heat loads and on the capability of the coolant to remove it. Furthermore, the heat power to the conductor will depend on several aspects, namely the thickness of insulating material, the mass flow rate of helium flowing in the conductors and its thermodynamic properties at operating conditions, and the layout of the superconductors constituting the winding. Moreover, a crucial aspect in the final design will be the presence and position of the casing cooling channels. In this paper a 2D sensitivity analysis of heat transfer from casing to winding pack with respect to cooling channels number and position is presented, based on the reference layout of the magnet. As a result, we evaluated the optimum number and positioning of cooling channels needed, as a trade-off between magnet operating limits and available cryogenic power and if, at limit, they could be even neglected in normal operation, keeping dwell-time within reasonable values.

  1. Burst Format Design for Optimum Joint Estimation of Doppler-Shift and Doppler-Rate in Packet Satellite Communications

    Directory of Open Access Journals (Sweden)

    Luca Giugno

    2007-05-01

    Full Text Available This paper considers the problem of optimizing the burst format of packet transmission to perform enhanced-accuracy estimation of Doppler-shift and Doppler-rate of the carrier of the received signal, due to relative motion between the transmitter and the receiver. Two novel burst formats that minimize the Doppler-shift and the Doppler-rate Cramér-Rao bounds (CRBs for the joint estimation of carrier phase/Doppler-shift and of the Doppler-rate are derived, and a data-aided (DA estimation algorithm suitable for each optimal burst format is presented. Performance of the newly derived estimators is evaluated by analysis and by simulation, showing that such algorithms attain their relevant CRBs with very low complexity, so that they can be directly embedded into new-generation digital modems for satellite communications at low SNR.

  2. Experimental use of Evazote joint materials

    Science.gov (United States)

    Coley, J. O.

    1981-09-01

    The performance of Evazote joint material is discussed. Merits and shortcomings noted in evaluations are listed. This material is designed to be used in expansion joints in roadways, bridges, sidewalks, roofs and walls, as well as other areas requiring a waterproof filler. Evazote material has been placed in joints on one bridge and in a number of highly expansive joints in prestressed concrete pavement.

  3. Joint Airspace Management and Deconfliction (JASMAD)

    Science.gov (United States)

    2009-01-01

    as they traverse in a designated polygonal airspace ( filtered from display...components to be demonstrated at multiple Joint User Group ( JUG ) Warfighter evaluation events and eventually provided to Northrop-Grumman PRB as software...System JASMAD Joint AirSpace Management And Deconfliction JAT Joint Accelerated Targeting JUG Joint Users Group MOD Ministry of Defence MSL Mean

  4. Preliminary bolted-joint data

    Science.gov (United States)

    Wichorek, G. R.

    1979-01-01

    Bolted-joint strength and failure modes for advanced graphite/polyimide composite laminates at 116K (-250 F), room temperature, and 589K (600 F) were determined to provide preliminary design data. The bolted-joint test setup for the low and elevated temperature tests is described. Test results are reported on a quasi-isotropic laminate of Celion 6000/PMR-15. Single bolt, double lap shear specimens were tested to obtain maximum joint strength and failure mode. The effect of joint geometry and temperature on joint strength and failure mode is presented.

  5. Engine mounts and structural joints

    Indian Academy of Sciences (India)

    properly implemented, a separate problem-specific solution must be constructed for each joint/structure problem considered. A more general set of analysis tools and design dynamics is required to understand existing designs better and to develop alternate joints based on new or improved welding processes. A problem is ...

  6. Room Temperature Magnetic Determination of the Current Center Line for the ITER TF Coils

    CERN Document Server

    Lerch, Philippe; Buzio, Marco; Negrazus, Marco; Baynham, Elwyn; Sanfilippo, Stephane; Foussat, Arnaud

    2014-01-01

    The ITER tokamak includes 18 superconducting D-shaped toroidal field (IT) coils. Unavoidable shape deformations as well as assembly errors will lead to field errors, which can be modeled with the knowledge of the current center line (CCL). Accurate survey during the entire manufacturing and assembly process, including transfer of survey points, is complex. In order to increase the level of confidence, a room temperature magnetic measurement of the CCL on assembled and closed winding packs is foreseen, prior to insertion into their cold case. In this contribution, we discuss the principle of the CCL determination and present a low frequency ac measurement system under development at PSI, within an ITER framework contract. The largest current allowed to flow in the TF coil at room temperature and the precision requirements for the determination of the CCL loci of the coil are hard boundaries. Eddy currents in the radial plates, the winding pack enclosures, and possibly from iron in the reinforced concrete floor...

  7. Tokamak Fusion Core Experiment: design studies based on superconducting and hybrid toroidal field coils. Design overview

    Energy Technology Data Exchange (ETDEWEB)

    Flanagan, C.A. (ed.)

    1984-10-01

    This document is a design overview that describes the scoping studies and preconceptual design effort performed in FY 1983 on the Tokamak Fusion Core Experiment (TFCX) class of device. These studies focussed on devices with all-superconducting toroidal field (TF) coils and on devices with superconducting TF coils supplemented with copper TF coil inserts located in the bore of the TF coils in the shield region. Each class of device is designed to satisfy the mission of ignition and long pulse equilibrium burn. Typical design parameters are: major radius = 3.75 m, minor radius = 1.0 m, field on axis = 4.5 T, plasma current = 7.0 MA. These designs relay on lower hybrid (LHRH) current rampup and heating to ignition using ion cyclotron range of frequency (ICRF). A pumped limiter has been assumed for impurity control. The present document is a design overview; a more detailed design description is contained in a companion document.

  8. Interleukin-6 Directly Impairs the Erythroid Development of Human TF-1 Erythroleukemic Cells

    Science.gov (United States)

    McCranor, Bryan J.; Kim, Min Jung; Cruz, Nicole M.; Xue, Qian-Li; Berger, Alan E.; Walston, Jeremy D.; Civin, Curt I.; Roy, Cindy N.

    2013-01-01

    Anemia of inflammation or chronic disease is a highly prevalent form of anemia. The inflammatory cytokine interleukin-6 (IL-6) negatively correlates with hemoglobin concentration in many disease states. The IL-6-hepcidin antimicrobial peptide axis promotes iron-restricted anemia; however the full role of IL-6 in anemia of inflammation is not well-defined. We previously reported that chronic inflammation had a negative impact on maturation of erythroid progenitors in a mouse model. We hypothesized that IL-6 may be responsible for impaired erythropoiesis, independent of iron restriction. To test the hypothesis we utilized the human erythroleukemia TF-1 cell line to model erythroid maturation and exposed them to varying doses of IL-6 over six days. At 10 ng/ml, IL-6 significantly repressed erythropoietin-dependent TF-1 erythroid maturation. While IL-6 did not decrease the expression of genes associated with hemoglobin synthesis, we observed impaired hemoglobin synthesis as demonstrated by decreased benzidine staining. We also observed that IL-6 down regulated expression of the gene SLC4a1 which is expressed late in erythropoiesis. Those findings suggested that IL-6-dependent inhibition of hemoglobin synthesis might occur. We investigated the impact of IL-6 on mitochondria. IL-6 decreased the mitochondrial membrane potential at all treatment doses, and significantly decreased mitochondrial mass at the highest dose. Our studies indicate that IL-6 may impair mitochondrial function in maturing erythroid cells resulting in impaired hemoglobin production and erythroid maturation. Our findings may indicate a novel pathway of action for IL-6 in the anemia of inflammation, and draw attention to the potential for new therapeutic targets that affect late erythroid development. PMID:24119518

  9. Enhanced human service transportation models : joint demonstration. Phase 1, System planning and design process evaluation : baseline analysis

    Science.gov (United States)

    2007-11-13

    This document presents the findings from the baseline phase of the evaluation of the process being used by eight sites to develop a design for a Travel Management Coordination Center (TMCC) for improved coordination of human service transportation wi...

  10. Structure and mechanical properties of Cresco-Ti laser-welded joints and stress analyses using finite element models of fixed distal extension and fixed partial prosthetic designs.

    Science.gov (United States)

    Uysal, Hakan; Kurtoglu, Cem; Gurbuz, Riza; Tutuncu, Naki

    2005-03-01

    The Cresco-Ti System uses a laser-welded process that provides an efficient technique to achieve passive fit frameworks. However, mechanical behavior of the laser-welded joint under biomechanical stress factors has not been demonstrated. This study describes the effect of Cresco-Ti laser-welding conditions on the material properties of the welded specimen and analyzes stresses on the weld joint through 3-dimensional finite element models (3-D FEM) of implant-supported fixed dentures with cantilever extensions and fixed partial denture designs. Twenty Grade III (ASTM B348) commercially pure titanium specimens were machine-milled to the dimensions described in the EN10002-1 tensile test standard and divided into test (n = 10) and control (n = 10) groups. The test specimens were sectioned and laser-welded. All specimens were subjected to tensile testing to determine yield strength (YS), ultimate tensile strength (UTS), and percent elongation (PE). The Knoop micro-indentation test was performed to determine the hardness of all specimens. On welded specimens, the hardness test was performed at the welded surface. Data were analyzed with the Mann-Whitney U test and Student's t test (alpha=.05). Fracture surfaces were examined by scanning electron microscopy to characterize the mode of fracture and identify defects due to welding. Three-dimensional FEMs were created that simulated a fixed denture with cantilever extensions supported by 5 implants (M1) and a fixed partial denture supported by 2 implants (M2), 1 of which was angled 30 degrees mesio-axially. An oblique load of 400 N with 15 degrees lingual-axial inclinations was applied to both models at various locations. Test specimens fractured between the weld and the parent material. No porosities were observed on the fractured surfaces. Mean values for YS, UTS, PE, and Knoop hardness were 428 +/- 88 MPa, 574 +/- 113 MPa, 11.2 +/- 0.4%, 270 +/- 17 KHN, respectively, for the control group and 642 +/- 2 MPa, 772 +/- 72

  11. Evaluation of mechanical strength of the joints in JT-60 toroidal field coil conductors

    Science.gov (United States)

    Nishio, S.; Ohkubo, M.; Sasajima, H.

    1980-04-01

    Toroidal field (TF) coils of JT-60 produce a toroidal field of 45 KG at a plasma axis, they have an inner bore of 3.90 m and a weight of about 80 metric tons per coil. Eighteen TF coils are located around a torus axis at regular intervals. TF coil conductors are mostly jointed by high frequency induction brazing, the rest jointed by welding. In deciding the details of the jointing procedures, the conductor size and the requested mechanical strength are mainly taken into consideration. Described are non-destructive inspection methods for the brazed joints, strength evaluation, and the inspection criteria. Ultrasonic testing method is found to be the most effective in evaluation of mechanical properties of the brazed joints especially in terms of fatigue strength. The ultrasonic inspection method and the detectability of this apparatus are described in detail, and the defects of known size are compared with the indication values and display figures. The apparatus developed for JT-60 is operated automatically also recording the inspection results. Mechanical strength of the brazed joints with initial defects is discussed.

  12. Ceramic joints

    Science.gov (United States)

    Miller, Bradley J.; Patten, Jr., Donald O.

    1991-01-01

    Butt joints between materials having different coefficients of thermal expansion are prepared having a reduced probability of failure of stress facture. This is accomplished by narrowing/tapering the material having the lower coefficient of thermal expansion in a direction away from the joint interface and not joining the narrow-tapered surface to the material having the higher coefficient of thermal expansion.

  13. CD81 Promotes Both the Degradation of Transferrin Receptor 2 (TfR2) and the Tfr2-mediated Maintenance of Hepcidin Expression*

    Science.gov (United States)

    Chen, Juxing; Enns, Caroline A.

    2015-01-01

    Mutations in transferrin receptor 2 (TfR2) cause a rare form of the hereditary hemochromatosis, resulting in iron overload predominantly in the liver. TfR2 is primarily expressed in hepatocytes and is hypothesized to sense iron levels in the blood to positively regulate the expression of hepcidin through activation of the BMP signaling pathway. Hepcidin is a peptide hormone that negatively regulates iron egress from cells and thus limits intestinal iron uptake. In this study, a yeast two-hybrid approach using the cytoplasmic domain of TfR2 identified CD81 as an interacting protein. CD81 is an abundant tetraspanin in the liver. Co-precipitations of CD81 with different TfR2 constructs demonstrated that both the cytoplasmic and ecto-transmembrane domains of TfR2 interact with CD81. Knockdown of CD81 using siRNA significantly increased TfR2 levels by increasing the half-life of TfR2, indicating that CD81 promotes degradation of TfR2. Previous studies showed that CD81 is targeted for degradation by GRAIL, an ubiquitin E3 ligase. Knockdown of GRAIL in Hep3B-TfR2 cells increased TfR2 levels, consistent with inhibition of CD81 ubiquitination. These results suggest that down-regulation of CD81 by GRAIL targets TfR2 for degradation. Surprisingly, knockdown of CD81 decreased hepcidin expression, implying that the TfR2/CD81 complex is involved in the maintenance of hepcidin mRNA. Moreover, knockdown of CD81 did not affect the stimulation of hepcidin expression by BMP6 but increased both the expression of ID1 and SMAD7, direct targets of BMP signaling pathway, and the phosphorylation of ERK1/2, indicating that the CD81 regulates hepcidin expression differently from the BMP and ERK1/2 signaling pathways. PMID:25635054

  14. Strength Variation of Parachute Joints

    Science.gov (United States)

    Mollmann, Catherine

    2017-01-01

    A parachute joint is defined as a location where a component is sewn or connected to another component. During the design and developmental phase of a parachute system, the joints for each structural component are isolated and tested through a process called seam and joint testing. The objective of seam and joint testing is to determine the degradation on a single component due to interaction with other components; this data is then used when calculating the margin of safety for that component. During the engineering developmental phase of CPAS (Capsule Parachute Assembly System), the parachute system for the NASA Orion Crew Module, testing was completed for every joint of the six subsystems: the four parachutes (main, drogue, pilot, and FBCP [forward bay cover parachute]), the retention release bridle, and the retention panels. The number of joint tests for these subsystems totaled 92, which provides a plethora of data and results for further analysis. In this paper, the data and results of these seam and joint tests are examined to determine the effects, if any, of different operators and sewing machines on the strength of parachute joints. Other variables are also studied to determine their effect on joint strength, such as joint complexity, joint strength magnitude, material type, and material construction. Findings reveal that an optimally-run seam and joint test program could result in an increased understanding of the structure of the parachute; this should lead to a parachute built with optimal components, potentially saving system weight and volume.

  15. Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells.

    Science.gov (United States)

    Griffiths, William J H; Cox, Timothy M

    2003-05-01

    Mutations in the HFE gene and a newly identified second transferrin receptor gene, TfR2, cause hemochromatosis. The cognate proteins, HFE and TfR2, are therefore of key importance in human iron homeostasis. HFE is expressed in small intestinal crypt cells where transferrin-iron entry may determine subsequent iron absorption by mature enterocytes, but the physiological function of TfR2 is unknown. Using specific peptide antisera, we examined the duodenal localization of HFE and TfR2 in humans and mice, with and without HFE deficiency, by confocal microscopy. We also investigated potential interactions of these proteins in human intestinal cells in situ. Duodenal expression of HFE and TfR2 (but not TfR1) in wild-type mice and humans was restricted to crypt cells, in which they co-localized. HFE deficiency disrupted this interaction, altering the cellular distribution of TfR2 in human crypts. In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron. This interaction occurs specifically in small intestinal crypt cells that differentiate to become iron-absorbing enterocytes. Our immunohistochemical findings provide evidence for a novel mechanism for the regulation of iron balance in mammals.

  16. Family learning with mobile devices in the outdoors: Designing an e-Trailguide to facilitate families' joint engagement with the natural world

    Science.gov (United States)

    McClain, Lucy R.

    This study describes the implementation of a self-guiding mobile learning tool designed to support families' engagements with the natural world as they explored the flora and fauna along one nature trail at an environmental center. Thirty-one family groups (n = 105 individuals) participated in this study during the summer season and used an iPad-based e-Trailguide during their nature walk. Design-based research methods guided this study's design, which focused on the third iteration of the e-Trailguide. Data included evaluation of families' content knowledge gains related to the local biodiversity as revealed through post-hike interviews, while videorecords of each family's nature walk experience were also collected. Qualitative analyses focused on the design features within the e-Trailguide that supported the families' technology-mediated engagements with nature and their interactions with each other at one Discovery Spot along the nature trail. Findings include: (a) open-ended interviews after the e-Trailguide experience provided a descriptive understanding of the families' conceptual knowledge gains; (b) four place-based design features within the e-Trailguide enabled and supported families' observational, pointing, and tactile investigation engagements with the natural world; (c) parents took on teacher-like roles for their children by connecting information from the e-Trailguide to the natural objects nearby as evidenced through their frequency of pointing gestures; and (d) the development of an analytical framework related to joint observation strategies used between family members to support science-related sense making. Design recommendations for the future implementation of e-Trailguides in outdoor settings include the incorporation of place-based observational questions, place-based textual prompts for focusing observations, drawing activities to record observations, and place-based images to support identification of wildlife. Key words: family learning

  17. Design and performance of a multi-centre randomised controlled trial and economic evaluation of joint tele-consultations [ISRCTN54264250

    Directory of Open Access Journals (Sweden)

    Thompson Simon

    2002-01-01

    Full Text Available Abstract Background Appropriate information flow is crucial to the care of patients, particularly at the interface between primary and secondary care. Communication problems can result from inadequate organisation and training, There is a major expectation that information and communication technologies may offer solutions, but little reliable evidence. This paper reports the design and performance of a multi-centre randomised controlled trial (RCT, unparalleled in telemedicine research in either scale or range of outcomes. The study investigated the effectiveness and cost implications in rural and inner-city settings of using videoconferencing to perform joint tele-consultations as an alternative to general practitioner referral to the hospital specialist in the outpatient clinic. Methods Joint tele-consultation services were established in both the Royal Free Hampstead NHS Trust in inner London, and the Royal Shrewsbury Hospitals Trust, in Shropshire. All the patients who gave consent to participate were randomised either to joint tele-consultation or to a routine outpatients appointment. The principal outcome measures included the frequency of decision by the specialist to offer a follow-up outpatient appointment, patient satisfaction (Ware Specific Questionnaire, wellbeing (SF12 and enablement (PEI, numbers of tests, investigations, procedures and treatments. Results A total of 134 general practitioners operating from 29 practices participated in the trial, referring a total of 3170 patients to 20 specialists in ENT medicine, general medicine (including endocrinology, and rheumatology, gastroenterology, orthopaedics, neurology and urology. Of these, 2094 patients consented to participate in the study and were correctly randomised. There was a 91% response rate to the initial assessment questionnaires, and analysis showed equivalence for all key characteristics between the treatment and control groups. Conclusion We have designed and

  18. Impact of sodium butyrate and mild hypothermia on metabolic and physiological behaviour of CHO TF 70R cells

    Directory of Open Access Journals (Sweden)

    Veronica Avello

    2017-05-01

    Conclusions: The combination of NaBu addition and mild hypothermic condition causes an impact on physiological and metabolic state of CHO TF 70R cells, decreasing cell growth rate and improving glucose consumption efficiency. These results therefore provide a promising strategy to increase specific productivity of rh-tPA.

  19. Joint Environmental Data at Five European Offshore Sites for Design of Combined Wind and Wave Energy Devices

    OpenAIRE

    Li, Lin; Gao, Zhen; Moan, Torgeir

    2013-01-01

    The costs for an offshore wind farm, especially with bottom fixed foundations increase significantly with increasing water depth. If costs can be reduced to a competitive level, the potential for wind farms in deep water is huge. One way of reducing costs might be to combine offshore wind with wave energy facilities at sites where these resources are concentrated. In order to design combined renewable energy concepts, it is important to choose sites where both wind and wave energy resourc...

  20. Joint Commission

    Science.gov (United States)

    ... Commission Websites Quick Links The Center for Transforming Healthcare Blogs DataMart Event ... Table of Contents and Abstracts for The Joint Commission Journal on Quality and Patient Safety Monday October 2, ...

  1. Joint pain

    Science.gov (United States)

    ... or conditions. It may be linked to arthritis , bursitis , and muscle pain . No matter what causes it, ... Autoimmune diseases such as rheumatoid arthritis and lupus Bursitis Chondromalacia patellae Crystals in the joint: Gout (especially ...

  2. Military Airlift: The Joint Cargo Aircraft Program

    National Research Council Canada - National Science Library

    Knight, William

    2007-01-01

    Joint Cargo Aircraft (JCA) is a joint acquisition program between the Army and the Air Force designed to procure a commercial off-the-shelf aircraft, capable of meeting Army requirements for "direct support" to maneuver units...

  3. Protocol optimization of sacroiliac joint MR Imaging at 3 Tesla: Impact of coil design and motion resistant sequences on image quality.

    Science.gov (United States)

    Gondim Teixeira, P A; Bravetti, M; Hossu, G; Lecocq, S; Petit, D; Loeuille, D; Blum, A

    2017-07-21

    To evaluate the impact of coil design and motion-resistant sequences on the quality of sacroiliac magnetic resonance imaging (MRI) examination in patients with spondyloarthropathy. One hundred and twenty-one patients with suspected sacroiliitis and referred for MRI of the sacroiliac joints were retrospectively evaluated with MRI at 3-Tesla. There were 78 women and 43 men with a mean age of 36.7±11.5 (SD) years (range: 15.8-78.4 years). Conventional and motion-resistant fat-saturated fast-spin echo T2-weighted sequences were performed with two different coils. Image quality was subjectively evaluated by two independent readers (R1 and R2) using a four-point scale. Confidence in the identification of bone marrow edema pattern (BMEP) was also evaluated subjectively using a three-point scale. Phased array body coil yielded improved image quality compared to surface coil (14.1 to 30.4% for R1 and 14.6 to 25.7% for R2; Pbody coil with motion-resistant T2-weighted sequence (kappa 0.990). The smallest number of indeterminate BMEP zones was seen on MRI set acquired with the phased-array body coil and motion-resistant T2-weighted sequence. Phased array body coil and motion-resistant T2-weighted sequences perform better than surface coil and conventional T2-weighted sequences for the evaluation of sacroiliac joints, increasing confidence in the identification of BMEP. Copyright © 2017 Editions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.

  4. Knee Joint Distraction as an Alternative Surgical Treatment for Osteoarthritis: Rationale and Design of two Randomized Controlled Trials (vs High Tibial Osteotomy and Total Knee Prosthesis

    Directory of Open Access Journals (Sweden)

    Karen Wiegant

    2015-08-01

    Full Text Available AIM: In case of refractory knee osteoarthritis at a relatively young age causing persisting pain, treatment options are limited. In case of medial degeneration high tibial osteotomy (HTO may be considered, or in case of more generalized OA, a total knee prosthesis (TKP. However, these young and active patients have a major risk of revision surgery. Knee joint distraction (KJD could be an alternative treatment; prolonged clinical benefit and cartilage tissue repair have been demonstrated. Therefore, two RCTs were designed, evaluating clinical efficacy and for HTO additionally comparing cartilage tissue repair. MATERIALS AND METHODS: Patients<65 years of age considered in regular clinical practice for TKP or HTO were included. TKP and HTO were performed according to usual standard of care. KJD was performed for six continuous weeks by use of an external fixator bridging the joint, fixed at each side to two bone pins. RESULTS: Inclusion rate was stable over time and took 42 and 22 months for TKP vs KJD and HTO vs KJD, respectively. At baseline, patient characteristics differed: age was 55.2±0.9 and 50.0±0.7 p<0.000, KOOS-score was 36.6±1.4 and 42.2±1.6 p=0.012, and VAS-pain was 68.7±2.1 and 61.4±2.4 p=0.028, in the KJD-TKP cohort and KJD-HTO cohort, respectively. CONCLUSIONS: For implementation of KJD a comparison with available surgical alternatives is needed. TKP and HTO were chosen as the most relevant comparators. Inclusion is closed, and all treatments are completed. Data have to be awaited to determine the position of KJD in surgical treatment of refractory knee OA.

  5. High fidelity analysis of BWR fuel assembly with COBRA-TF/PARCS and trace codes

    Energy Technology Data Exchange (ETDEWEB)

    Abarca, A.; Miro, R.; Barrachina, T.; Verdu, G., E-mail: aabarca@isirym.upv.es, E-mail: rmiro@iqn.upv.es, E-mail: tbarrachina@isirym.upv.es, E-mail: gverdu@iqn.upv.es [Universitat Politecnica de Valencia, (ISIRYM/UPV), (Spain). Institute for Industrial, Radiophysical and Environmental Safety; Concejal, A.; Melara, J.; Albendea, M., E-mail: acbe@iberdrola.es, E-mail: jls@iberdrola.es, E-mail: manuel.albendea@iberdrola.es [Iberdrola, Madrid (Spain); Soler, A., E-mail: asoler@iberdrola.es [SEA Propulsion SL, Madrid (Spain)

    2013-07-01

    The growing importance of detailed reactor core and fuel assembly description for light water reactors (LWRs) as well as the sub-channel safety analysis requires high fidelity models and coupled neutronic/thermalhydraulic codes. Hand in hand with advances in the computer technology, the nuclear safety analysis is beginning to use a more detailed thermal hydraulics and neutronics. Previously, a PWR core and a 16 by 16 fuel assembly models were developed to test and validate our COBRA-TF/PARCS v2.7 (CTF/PARCS) coupled code. In this work, a comparison of the modeling and simulation advantages and disadvantages of modern 10 by 10 BWR fuel assembly with CTF/PARCS and TRACE codes has been done. The objective of the comparison is making known the main advantages of using the sub-channel codes to perform high resolution nuclear safety analysis. The sub-channel codes, like CTF, permits obtain accurate predictions, in two flow regime, of the thermalhydraulic parameters important to safety with high local resolution. The modeled BWR fuel assembly has 91 fuel rods (81 full length and 10 partial length fuel rods) and a big square central water rod. This assembly has been modeled with high level of detail with CTF code and using the BWR modeling parameters provided by TRACE. The same neutronic PARCS's model has been used for the simulation with both codes. To compare the codes a coupled steady state has be performed. (author)

  6. Ion Pair Structure and Photodissociation Dynamics of Ionic Liquid [EMIM][TF2N

    Science.gov (United States)

    Stearns, Jaime A.; Cooper, Russell; Sporleder, David; Zolot, Alexander M.; Boatz, Jerry

    2014-06-01

    The Air Force has a pressing need to find new means of spacecraft propulsion, enabling cheaper, safer, more efficient maneuvering on orbit. Ionic liquids are a potential replacement for hydrazine in hypergolic combustion propellant systems and for xenon in electric propulsion systems. However, both applications require considerable further development, leading us to study the fundamental structural and optical properties of candidate systems. Our benchmark measurements will provide validation of theoretical models of all types, from ab initio methods up to codes describing full thruster plumes. Using standard supersonic jet time-of-flight spectroscopy techniques, we have measured the ultraviolet and infrared spectra of ion pairs of the only space-qualified ionic liquid, [emim][Tf2N]. The ultraviolet photodissociation spectrum, though broad and essentially featureless, reveals rich underlying photodynamics involving both single- and multi-photon excitations and a wealth of interacting excited states. The infrared spectrum and MP2 calculations establish the structure as one in which the cation and anion are stacked on top of one another rather than sitting in the same plane, answering a long-standing question in this field. The complexity of the infrared spectrum and its behavior under varying jet temperatures indicates the presence of multiple conformations and likely contributions from Fermi resonance.

  7. Conceptual Thermal Hydraulic Design of a 20MW Multipurpose Research Reactor (KAERI/VAEC joint study on a new research reactor for Vietnam)

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Hee Taek; Seo, Chul Gyo; Park, Jong Hark; Park, Cheol [Kaeri, Daejeon (Korea, Republic of); Vinh, Le Vinh; Nghiem, Huynh Ton; Dang, Vo Doan Hai [Dalat Nuclear Research Reactor, Hanoi (Viet Nam)

    2007-08-15

    The conceptual thermal hydraulics design analyses for the 20 MW reference AHR core have been jointly performed by the KAERI and DNRI(VAEC). The preliminary core thermal hydraulic characteristics and safety margins for the AHR core were studied for various core flow rates, fuel assembly powers and core inlet temperatures. Statistical method was applied to the thermal hydraulic design of the reactor core. The MATRA{sub h} subchannel code has been applied to evaluate the thermal hydraulic performances of the AHR and the resulting thermal margins of the core under the forced convection cooling mode during a nominal power operation and the natural circulation mode during a reactor shutdown condition. In addition, typical accident analyses were carried out for a loss of flow accident by a primary pump seizure and a reactivity induced accident by a CAR rod withdrawal during a normal full power operation. The normal full power operation of the AHR was ensured with a sufficient safety margin for the onset of nucleate boiling phenomena. The AHR also had a sufficient natural circulation cooling capability to cool the core without the onset of nucleate boiling in the channel after a normal reactor shutdown and the anticipated transients. It was confirmed by the typical accident analyses that the AHR core was sufficiently protected from the loss of flow by the primary cooling pump seizure and the overpower transients by the CAR withdrawal from the MCHFR and fuel temperature points of view.

  8. Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway in Vitro and in a Rodent Model

    Directory of Open Access Journals (Sweden)

    Hongchen Ji

    2015-05-01

    Full Text Available Background: The activation of tissue factor (TF is one of the major reasons for coagulation dysregulation after pig-to-primate xenotransplantation. Tissue factor pathway inhibitor (TFPI is the most important inhibitor of TF. Studies have demonstrated species incompatibility between pig TFPI and human TF. Methods: A pig-to-macaque heterotopic auxiliary liver transplantation model was established to determine the origin of activated TF. Chimeric proteins of human and pig TFPI were constructed to assess the role of Kunitz domains in species incompatibility. Immortalised pig bone marrow mesenchymal stem cells transfected with human TFPI were tested for their ability to inhibit clotting in vitro. Results: TF from recipient was activated early after liver xenotransplantation. Pig TFPI Kunitz domain 2 bound human FXa, but Kunitz domain 1 did not effectively inhibit human TF/FVIIa. Immortalised pig bone marrow mesenchymal cells (BMSCs transfected with human TFPI showed a prolonged recalcification time in vitro and in a rodent model. Conclusion: Recipient TF is relevant to dysregulated coagulation after xenotransplantation. Kunitz domain 1 plays the most important role in species incompatibility between pig TFPI and human TF, and clotting can be inhibited by human TFPI-transfected pig BMSCs. Our study shows a possible way to resolve the incompatibility of pig TFPI.

  9. A study on composite adhesive lap joint

    Science.gov (United States)

    Zeng, Qinggang

    In this study, a novel design of adhesive single-lap joint was proposed and investigated. In this new design, load eccentricity as well as singular peel stresses in the joint interface were avoided. In fact, numerical calculations show that, in the new design, the interfacial normal stress becomes compressive in the joint end region, and the shear load is more evenly transferred over the length of the joint. Experimental results using cross-ply carbon/epoxy composites as adherends show that the strength of the new joint is significantly higher than that of the conventional single lap joint. Efforts were made to investigate effects of the four most relevant design parameters of the wavy joint on the critical interfacial stress distributions. By careful selecting the design parameters, interfacial stresses can further be optimized. Test results with unidirectional composite adherends confirm that joint strength can further be improved through careful design. In order to fully demonstrate advantage of the new wavy-lap joint over the conventional single-lap joint, fatigue tests were carried out to determine durability performance of the wavy-lap joint. Fatigue tests show that under the same loading conditions, i.e. same maximum load levels or same load percentage levels, fatigue performance of the wavy-lap joint is much better than that of the conventional single-lap joint. Further study shows that fatigue life of adhesive joint, either flat or wavy, is strongly dependent on loading frequency. This is due to the fact that FM73 adhesive is a viscoelastic material. With the increase of frequency, fatigue lives of both joints also increase. However, the wavy joint still outperforms the flat joint at all loading frequencies.

  10. Keyed shear joints

    DEFF Research Database (Denmark)

    Hansen, Klaus

    This report gives a summary of the present information on the behaviour of vertical keyed shear joints in large panel structures. An attemp is made to outline the implications which this information might have on the analysis and design of a complete wall. The publications also gives a short...

  11. Variable Joint Elasticities in Running

    Science.gov (United States)

    Peter, Stephan; Grimmer, Sten; Lipfert, Susanne W.; Seyfarth, Andre

    In this paper we investigate how spring-like leg behavior in human running is represented at joint level. We assume linear torsion springs in the joints and between the knee and the ankle joint. Using experimental data of the leg dynamics we compute how the spring parameters (stiffness and rest angles) change during gait cycle. We found that during contact the joints reveal elasticity with strongly changing parameters and compare the changes of different parameters for different spring arrangements. The results may help to design and improve biologically inspired spring mechanisms with adjustable parameters.

  12. TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway.

    Science.gov (United States)

    Calzolari, Alessia; Raggi, Carla; Deaglio, Silvia; Sposi, Nadia Maria; Stafsnes, Marit; Fecchi, Katia; Parolini, Isabella; Malavasi, Fabio; Peschle, Cesare; Sargiacomo, Massimo; Testa, Ugo

    2006-11-01

    Transferrin receptor 2 (TfR2) possesses a YQRV motif similar to the YTRF motif of transferrin receptor 1 (TfR1) responsible for the internalization and secretion through the endosomal pathway. Raft biochemical dissection showed that TfR2 is a component of the low-density Triton-insoluble (LDTI) plasma membrane domain, able to co-immunoprecipitate with caveolin-1 and CD81, two structural raft proteins. In addition, subcellular fractionation experiments showed that TfR1, which spontaneously undergoes endocytosis and recycling, largely distributed to intracellular organelles, whereas TfR2 was mainly associated with the plasma membrane. Given the TfR2 localization in lipid rafts, we tested its capability to activate cell signalling. Interaction with an anti-TfR2 antibody or with human or bovine holotransferrin showed that it activated ERK1/ERK2 and p38 MAP kinases. Integrity of lipid rafts was required for MAPK activation. Co-localization of TfR2 with CD81, a raft tetraspanin exported through exosomes, prompted us to investigate exosomes released by HepG2 and K562 cells into culture medium. TfR2, CD81 and to a lesser extent caveolin-1, were found to be part of the exosomal budding vesicles. In conclusion, the present study indicates that TfR2 localizes in LDTI microdomains, where it promotes cell signalling, and is exported out of the cells through the exosome pathway, where it acts as an intercellular messenger.

  13. Design and Kinematic Evaluation of a Novel Joint-Specific Play Controller: Application for Wrist and Forearm Therapy.

    Science.gov (United States)

    Crisco, Joseph J; Schwartz, Joel B; Wilcox, Bethany; Costa, Laura; Kerman, Karen

    2015-07-01

    The wrist extensors and flexors are profoundly affected in most children with hemiparetic cerebral palsy (CP) and are the major target of physical therapists' and occupational therapists' efforts to restore useful hand functions. A limitation of any therapeutic or exercise program can be the level of the child's engagement or adherence. The proposed approach capitalizes on the primary learning avenue for children: toy play. This study aimed to develop and evaluate the measurement accuracy of innovative, motion-specific play controllers that are engaging rehabilitative devices for enhancing therapy and promoting neural plasticity and functional recovery in children with CP. Design objectives of the play controller included a cost-effective, home-based supplement to physical therapy, the ability to calibrate the controller so that play can be accomplished with any active range of motion, and the capability of logging play activity and wrist motion over week-long periods. Accuracy of the play controller in measuring wrist flexion-extension was evaluated in 6 children who were developing in a typical manner, using optical motion capture of the wrist and forearm as the gold standard. The error of the play controller was estimated at approximately 5 degrees in both maximum wrist flexion and extension. Measurements were taken during a laboratory session, with children without CP, and no toy or computer game was interfaced with the play controller. Therefore, the potential engagement of the proposed approach for therapy remains to be evaluated. This study presented the concept, development, and wrist tracking accuracy of an inexpensive approach to extremity therapy that may have a health benefit for children with hemiparesis, and potentially for patients of any age with a wide range of extremity neuromotor impairments. © 2015 American Physical Therapy Association.

  14. Evaluation of in vivo quantification accuracy of the Ingenuity-TF PET/MR.

    Science.gov (United States)

    Maus, Jens; Schramm, Georg; Hofheinz, Frank; Oehme, Liane; Lougovski, Alexandr; Petr, Jan; Platzek, Ivan; Beuthien-Baumann, Bettina; Steinbach, Jörg; Kotzerke, Jörg; van den Hoff, Jörg

    2015-10-01

    The quantitative accuracy of standardized uptake values (SUVs) and tracer kinetic uptake parameters in patient investigations strongly depends on accurate determination of regional activity concentrations in positron emission tomography (PET) data. This determination rests on the assumption that the given scanner calibration is valid in vivo. In a previous study, we introduced a method to test this assumption. This method allows to identify discrepancies in quantitative accuracy in vivo by comparison of activity concentrations of urine samples measured in a well-counter with activity concentrations extracted from PET images of the bladder. In the present study, we have applied this method to the Philips Ingenuity-TF PET/MR since at the present stage, absolute quantitative accuracy of combined PET/MR systems is still under investigation. Twenty one clinical whole-body F18-FDG scans were included in this study. The bladder region was imaged as the last bed position and urine samples were collected afterward. PET images were reconstructed including MR-based attenuation correction with and without truncation compensation and 3D regions-of-interest (ROIs) of the bladder were delineated by three observers. To exclude partial volume effects, ROIs were concentrically shrunk by 8-10 mm. Then, activity concentrations were determined in the PET images for the bladder and for the urine by measuring the samples in a calibrated well-counter. In addition, linearity measurements of SUV vs singles rate and measurements of the stability of the coincidence rate of "true" events of the PET/MR system were performed over a period of 4 months. The measured in vivo activity concentrations were significantly lower in PET/MR than in the well-counter with a ratio of the former to the latter of 0.756 ± 0.060 (mean ± std. dev.), a range of 0.604-0.858, and a P value of 3.9 ⋅ 10(-14). While the stability measurements of the coincidence rate of "true" events showed no relevant deviation over

  15. Evaluation of in vivo quantification accuracy of the Ingenuity-TF PET/MR

    Energy Technology Data Exchange (ETDEWEB)

    Maus, Jens, E-mail: j.maus@hzdr.de; Schramm, Georg; Hofheinz, Frank; Lougovski, Alexandr; Petr, Jan; Steinbach, Jörg [PET Center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden (Germany); Oehme, Liane; Beuthien-Baumann, Bettina; Kotzerke, Jörg [Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden (Germany); Platzek, Ivan [Department of Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden (Germany); Hoff, Jörg van den [PET Center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden, Germany and Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden (Germany)

    2015-10-15

    Purpose: The quantitative accuracy of standardized uptake values (SUVs) and tracer kinetic uptake parameters in patient investigations strongly depends on accurate determination of regional activity concentrations in positron emission tomography (PET) data. This determination rests on the assumption that the given scanner calibration is valid in vivo. In a previous study, we introduced a method to test this assumption. This method allows to identify discrepancies in quantitative accuracy in vivo by comparison of activity concentrations of urine samples measured in a well-counter with activity concentrations extracted from PET images of the bladder. In the present study, we have applied this method to the Philips Ingenuity-TF PET/MR since at the present stage, absolute quantitative accuracy of combined PET/MR systems is still under investigation. Methods: Twenty one clinical whole-body F18-FDG scans were included in this study. The bladder region was imaged as the last bed position and urine samples were collected afterward. PET images were reconstructed including MR-based attenuation correction with and without truncation compensation and 3D regions-of-interest (ROIs) of the bladder were delineated by three observers. To exclude partial volume effects, ROIs were concentrically shrunk by 8–10 mm. Then, activity concentrations were determined in the PET images for the bladder and for the urine by measuring the samples in a calibrated well-counter. In addition, linearity measurements of SUV vs singles rate and measurements of the stability of the coincidence rate of “true” events of the PET/MR system were performed over a period of 4 months. Results: The measured in vivo activity concentrations were significantly lower in PET/MR than in the well-counter with a ratio of the former to the latter of 0.756 ± 0.060 (mean ± std. dev.), a range of 0.604–0.858, and a P value of 3.9 ⋅ 10{sup −14}. While the stability measurements of the coincidence rate of

  16. Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf/J mice.

    Science.gov (United States)

    Amodeo, Dionisio A; Yi, Julia; Sweeney, John A; Ragozzino, Michael E

    2014-01-01

    Repetitive behaviors with restricted interests is one of the core criteria for the diagnosis of autism spectrum disorder (ASD). Current pharmacotherapies that target the dopaminergic or serotonergic systems have limited effectiveness in treating repetitive behaviors. Previous research has demonstrated that administration of muscarinic cholinergic receptor (mAChR) antagonists can exacerbate motor stereotypies while mAChR agonists reduce stereotypies. The present study determined whether the mAChR agonist, oxotremorine affected repetitive behaviors in the BTBR T+ tf/J (BTBR) mouse model of autism. To test the effects of oxotremorine on repetitive behaviors, marble burying and grooming behavior were measured in BTBR mice and compared to that in C57BL/6J (B6) mice. The effects of oxotremorine on locomotor activity was also measured. Thirty minutes before each test, mice received an intraperitoneal (ip) injection of saline, 0.001 mg or 0.01 mg of oxotremorine methiodide. Saline- treated BTBR mice exhibited increased marble burying and self-grooming behavior compared to that of saline-treated B6 mice. Oxotremorine significantly reduced marble burying and self-grooming behavior in BTBR mice, but had no significant effect in B6 mice. In addition, oxotremorine did not affect locomotor activity in BTBR mice, but significantly reduced locomotor activity in B6 mice at the 0.01 mg dose. These findings demonstrate that activation of mAChRs reduces repetitive behavior in the BTBR mouse and suggest that treatment with a mAChR agonist may be effective in reducing repetitive behaviors in ASD.

  17. Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf/J mice

    Directory of Open Access Journals (Sweden)

    Dionisio A. Amodeo

    2014-08-01

    Full Text Available Repetitive behaviors with restricted interests is one of the core criteria for the diagnosis of autism spectrum disorder (ASD. Current pharmacotherapies that target the dopaminergic or serotonergic systems have limited effectiveness in treating repetitive behaviors. Previous research has demonstrated that administration of muscarinic cholinergic receptor (mAChR antagonists can exacerbate motor stereotypies while mAChR agonists reduce stereotypies. The present study determined whether the mAChR agonist, oxotremorine affected repetitive behaviors in the BTBR T+ tf/J (BTBR mouse model of autism. To test the effects of oxotremorine on repetitive behaviors, marble burying and grooming behavior were measured in BTBR mice and compared to that in C57BL/6J (B6 mice. The effects of oxotremorine on locomotor activity was also measured. Thirty minutes before each test, mice received an intraperitoneal injection of saline, 0.001 mg or 0.01 mg of oxotremorine methiodide. Saline- treated BTBR mice exhibited increased marble burying and self-grooming behavior compared to that of saline-treated B6 mice. Oxotremorine significantly reduced marble burying and self-grooming behavior in BTBR mice, but had no significant effect in B6 mice. In addition, oxotremorine did not affect locomotor activity in BTBR mice, but significantly reduced locomotor activity in B6 mice at the 0.01 mg dose. These findings demonstrate that activation of mAChRs reduces repetitive behavior in the BTBR mouse and suggest that treatment with a mAChR agonist may be effective in reducing repetitive behaviors in ASD.

  18. Fusion of Potentiometric & Voltammetric Electronic Tongue for Classification of Black Tea Taste based on Theaflavins (TF) Content

    Science.gov (United States)

    Bhattacharyya, Nabarun; Legin, Andrey; Papieva, Irina; Sarkar, Subrata; Kirsanov, Dmitry; Kartsova, Anna; Ghosh, Arunangshu; Bandyopadhyay, Rajib

    2011-09-01

    Black tea is an extensively consumed beverage worldwide with an expanding market. The final quality of black tea depends upon number of chemical compounds present in the tea. Out of these compounds, theaflavins (TF), which is responsible for astringency in black tea, plays an important role in determining the final taste of the finished black tea. The present paper reports our effort to correlate the theaflavins contents with the voltammetric and potentiometric electronic tongue (e-tongue) data. Noble metal-based electrode array has been used for collecting data though voltammetric electronic tongue where as liquid filled membrane based electrodes have been used for potentiometric electronic tongue. Black tea samples with tea taster score and biochemical results have been collected from Tea Research Association, Tocklai, India for the analysis purpose. In this paper, voltammetric and potentiometric e-tongue responses are combined to demonstrate improvement of cluster formation among tea samples with different ranges of TF values.

  19. Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71

    Directory of Open Access Journals (Sweden)

    Rosalba Parenti

    2014-01-01

    Full Text Available Anaplastic thyroid carcinoma (ATC is one of the most aggressive human cancers. Actually, ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine (131I therapy. Accordingly, genetic and molecular characterizations of ATC have been frequently and periodically reviewed in order to identify potential biological markers exploitable for target therapy. This review briefly focuses on main molecular events that characterize ATC and provides an update about preclinical studies. In addition, the overexpression of transferrin receptor 1 (TfR1/CD71 by neoplastic cells of ATC is emphasized in that it could represent a potential therapeutic target. In this regard, new therapeutic approaches based on the use of monoclonal or recombinant antibodies, or transferrin-gallium-TfR1/CD71 molecular complexes, or lastly small interfering RNAs (siRNAs are proposed.

  20. Unusual solvatochromic absorbance probe behaviour within mixtures of poly(ethylene glycol)-400+ionic liquid, [bmim][Tf2N].

    Science.gov (United States)

    Ali, Anwar; Ali, Maroof; Malik, Nisar Ahmad; Uzair, Sahar

    2014-01-01

    The potentially green solvents made up of ionic liquids (ILs) and poly(ethylene glycols) may have wide range of the applications in many chemical and biochemical fields. In the present work, solvatochromic absorbance probe behaviour is used to assess the physicochemical properties of the mixtures composed of PEG-400+IL, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, [bmim][Tf2N]. Lowest energy intramolecular charge-transfer absorbance maxima of a betaine dye, i.e., E(T)(N), indicates the dipolarity/polarizability and/or hydrogen-bond donating (HBD) acidity of the [bmim][Tf2N]+PEG-400 mixtures to be even higher than that of neat [bmim][Tf2N], the solution component with higher dipolarity/polarizability and/or HBD acidity. Dipolarity/polarizability (π(∗)) obtained separately from the electronic absorbance response of probe N,N-diethyl-4-nitroaniline, and the HBD acidity (α) of PEG-400+[bmim][Tf2N] mixtures are also observed to be anomalously high. A comparative study of the PEG+IL mixtures has also been done with PEG-400+molecular organic solvents (protic polar [methanol], aprotic polar [N,N-dimethylformamide], and non polar, [benzene]) mixtures, but these mixtures do not show this type of unusual behaviour. A four-parameter simplified combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) equation is shown to satisfactorily predict the solvatochromic parameters within PEG-400+different solvent mixtures. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. In-session caregiver behavior predicts symptom change in youth receiving trauma-focused cognitive behavioral therapy (TF-CBT).

    Science.gov (United States)

    Yasinski, Carly; Hayes, Adele M; Ready, C Beth; Cummings, Jorden A; Berman, Ilana S; McCauley, Thomas; Webb, Charles; Deblinger, Esther

    2016-12-01

    Involving caregivers in trauma-focused treatments for youth has been shown to result in better outcomes, but it is not clear which in-session caregiver behaviors enhance or inhibit this effect. The current study examined the associations between caregiver behaviors during Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) and youth cognitive processes and symptoms. Participants were a racially diverse sample of Medicaid-eligible youth (ages 7-17) and their nonoffending caregivers (N = 71 pairs) who received TF-CBT through an effectiveness study in a community setting. Caregiver and youth processes were coded from audio-recorded sessions, and outcomes were measured using the Child Behavior Checklist (CBCL) and UCLA PTSD Reaction Index for Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition (DSM-IV; UPID) at 3, 6, 9, and 12 months postintake. Piecewise linear growth curve modeling revealed that during the trauma narrative phase of TF-CBT, caregivers' cognitive-emotional processing of their own and their child's trauma-related reactions predicted decreases in youth internalizing and externalizing symptoms over treatment. Caregiver support predicted lower internalizing symptoms over follow-up. In contrast, caregiver avoidance and blame of the child predicted worsening of youth internalizing and externalizing symptoms over follow-up. Caregiver avoidance early in treatment also predicted worsening of externalizing symptoms over follow-up. During the narrative phase, caregiver blame and avoidance were correlated with more child overgeneralization of trauma beliefs, and blame was also associated with less child accommodation of balanced beliefs. The association between in-session caregiver behaviors and youth symptomatology during and after TF-CBT highlights the importance of assessing and targeting these behaviors to improve clinical outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  2. Joint purpose?

    DEFF Research Database (Denmark)

    Pristed Nielsen, Helene

    2013-01-01

    of anti-discrimination in Europe today? And what empirical evidence may be found for such a joint approach? The paper discusses how the contemporary EU context differs from the American context which prompted Crenshaw to raise the point about intersectionality, and it analyses documents and interviews...

  3. AVAQ 594-597 deletion of the TfR2 gene in a Japanese family with hemochromatosis.

    Science.gov (United States)

    Hattori, Ai; Wakusawa, Shinnya; Hayashi, Hisao; Harashima, Ai; Sanae, Fujiko; Kawanaka, Miwa; Yamada, Gohtaro; Yano, Motoyashi; Yoshioka, Kenntaro

    2003-06-01

    The majority of Caucasian patients with hemochromatosis are homozygous for C282Y mutation of the HFE gene. In contrast to its high prevalence in Caucasians, hemochromatosis is a rare disorder in Japan. This may be due to the low prevalence of the C282Y mutation of the HFE gene in Japanese. Recent reports suggest that the mutations of transferrin receptor 2 (TfR2) gene may be involved in non-HFE hemochromatosis. Therefore, we investigated the TfR2 gene of 6 sporadic and 5 familiar cases of Japanese hemochromatosis. Three siblings in one family were found to be homozygous for an AVAQ 594-597 deletion. All three had severe iron deposits in the hepatocytes and bile ducts, but none was affected by diabetes mellitus. This mutation was not detected in 100 control individuals. Further study was undertaken to investigate whether the large deletion of the TfR2 gene is the mutation responsible for some of the Japanese hemochromatosis cases.

  4. 30 CFR 36.24 - Engine joints.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Engine joints. 36.24 Section 36.24 Mineral... Construction and Design Requirements § 36.24 Engine joints. (a) Cylinder head. The joint between the cylinder head and block of the engine shall be fitted with a metal or metal-clad gasket satisfactory to MSHA...

  5. 14 CFR 25.693 - Joints.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Joints. 25.693 Section 25.693 Aeronautics... STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Control Systems § 25.693 Joints. Control system joints (in push-pull systems) that are subject to angular motion, except those in ball and roller...

  6. Using the American alligator and a repeated-measures design to place constraints on in vivo shoulder joint range of motion in dinosaurs and other fossil archosaurs.

    Science.gov (United States)

    Hutson, Joel D; Hutson, Kelda N

    2013-01-15

    Using the extant phylogenetic bracket of dinosaurs (crocodylians and birds), recent work has reported that elbow joint range of motion (ROM) studies of fossil dinosaur forearms may be providing conservative underestimates of fully fleshed in vivo ROM. As humeral ROM occupies a more central role in forelimb movements, the placement of quantitative constraints on shoulder joint ROM could improve fossil reconstructions. Here, we investigated whether soft tissues affect the more mobile shoulder joint in the same manner in which they affect elbow joint ROM in an extant archosaur. This test involved separately and repeatedly measuring humeral ROM in Alligator mississippiensis as soft tissues were dissected away in stages to bare bone. Our data show that the ROMs of humeral flexion and extension, as well as abduction and adduction, both show a statistically significant increase as flesh is removed, but then decrease when the bones must be physically articulated and moved until they separate from one another and/or visible joint surfaces. A similar ROM pattern is inferred for humeral pronation and supination. All final skeletonized ROMs were less than initial fully fleshed ROMs. These results are consistent with previously reported elbow joint ROM patterns from the extant phylogenetic bracket of dinosaurs. Thus, studies that avoid separation of complementary articular surfaces may be providing fossil shoulder joint ROMs that underestimate in vivo ROM in dinosaurs, as well as other fossil archosaurs.

  7. CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression.

    Science.gov (United States)

    Chen, Juxing; Enns, Caroline A

    2015-03-20

    Mutations in transferrin receptor 2 (TfR2) cause a rare form of the hereditary hemochromatosis, resulting in iron overload predominantly in the liver. TfR2 is primarily expressed in hepatocytes and is hypothesized to sense iron levels in the blood to positively regulate the expression of hepcidin through activation of the BMP signaling pathway. Hepcidin is a peptide hormone that negatively regulates iron egress from cells and thus limits intestinal iron uptake. In this study, a yeast two-hybrid approach using the cytoplasmic domain of TfR2 identified CD81 as an interacting protein. CD81 is an abundant tetraspanin in the liver. Co-precipitations of CD81 with different TfR2 constructs demonstrated that both the cytoplasmic and ecto-transmembrane domains of TfR2 interact with CD81. Knockdown of CD81 using siRNA significantly increased TfR2 levels by increasing the half-life of TfR2, indicating that CD81 promotes degradation of TfR2. Previous studies showed that CD81 is targeted for degradation by GRAIL, an ubiquitin E3 ligase. Knockdown of GRAIL in Hep3B-TfR2 cells increased TfR2 levels, consistent with inhibition of CD81 ubiquitination. These results suggest that down-regulation of CD81 by GRAIL targets TfR2 for degradation. Surprisingly, knockdown of CD81 decreased hepcidin expression, implying that the TfR2/CD81 complex is involved in the maintenance of hepcidin mRNA. Moreover, knockdown of CD81 did not affect the stimulation of hepcidin expression by BMP6 but increased both the expression of ID1 and SMAD7, direct targets of BMP signaling pathway, and the phosphorylation of ERK1/2, indicating that the CD81 regulates hepcidin expression differently from the BMP and ERK1/2 signaling pathways. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. Joint Hypermobility: What Causes Loose Joints?

    Science.gov (United States)

    ... result in a higher incidence of dislocations and sprains. Your doctor might suggest physical therapy to help strengthen the muscles surrounding these joints. See your doctor if your loose joints also cause you pain. Rarely, joint hypermobility is a sign ...

  9. Affecting aspects on the behaviour of frame joints

    OpenAIRE

    Nabil, Mohamed; Hamdy, Osama; Abobeah, Ayman

    2016-01-01

    The variation of reinforcement details, confinement and joints angle are considerable factors which affect the ultimate limit moment of joints and joints efficiency. The variation of joint size is another factor that significantly affects the ultimate limit moment of joints and frame joints efficiency. These previous factors were not considered in design. Corners may be subjected to closing moments, which subject to tensile stresses in the outside of the corner, or to opening moments, which c...

  10. A systematic review assessing non-pharmacological conservative treatment studies for people with non-inflammatory multi-joint pain: clinical outcomes and research design considerations.

    Science.gov (United States)

    Comer, C; Smith, T O; Drew, B; Raja, R; Kingsbury, S R; Conaghan, Philip G

    2017-11-16

    To systematically review the evidence to determine the clinical outcomes and the important methodological quality features of interventional studies on adults with non-inflammatory multi-joint pain (MJP). Systematic search of published and unpublished literature using the databases: AMED, CINAHL, MEDLINE, EMBASE, psycINFO, SPORTDiscus, PEDro, OpenGrey, the EU Clinical Trials Register, World Health Organization International Clinical Trial Registry Platform, ClinicalTrials.gov and the ISRCTN registry (search: inception to 19th October 2017). All papers reporting the clinical outcomes of non-pharmacological interventions for people with non-inflammatory MJP were included. Studies were critically appraised using the Downs and Black Critical Appraisal and the TIDieR reporting checklists. Data were analysed using a Best Evidence Synthesis approach. From 3824 citations, four papers satisfied the eligibility criteria. Three studies reported outcomes from multidisciplinary rehabilitation programmes and one study reported the findings of a spa therapy intervention. All interventions significantly improved pain, function and quality of life in the short-term. There was limited reporting of measures for absenteeism, presenteeism and psychosocial outcomes. The evidence was 'weak', and due to a lack of controlled trials, there is limited evidence to ascertain treatment effectiveness. Design consideration for future trials surround improved reporting of participant characteristics, interventions and the standardisation of core outcome measures. There is insufficient high-quality trial data to determine the effectiveness of treatments for non-inflammatory MJP. Given the significant health burden which this condition presents on both individuals and wider society, developing and testing interventions and accurately reporting these, should be a research priority. Registration PROSPERO (CRD42013005888).

  11. Studies of welded joints

    Directory of Open Access Journals (Sweden)

    J. M. Krupa

    2010-07-01

    Full Text Available Studies of a welded joint were described. The joint was made as a result of the reconstruction of a truss and one of the possible means to make a repair. The studies were of a simulation character and were targeted at the detection of welding defects and imperfections thatshould be eliminated in a real structure. A model was designed and on this model the tests and examinations were carried out. The modelwas made under the same conditions as the conditions adopted for repair. It corresponded to the real object in shape and dimensions, and in the proposed technique of welding and welding parameters. The model was composed of five plates joined together with twelve beads.The destructive and non-destructive tests were carried out; the whole structure and the respective welds were also examined visually. Thedefects and imperfections in welds were detected by surface methods of inspection, penetration tests and magnetic particle flaw detection.The model of the welded joint was prepared by destructive methods, a technique that would never be permitted in the case of a realstructure. For the investigations it was necessary to cut out the specimens from the welded joint in direction transverse to the weld run. The specimens were subjected to metallographic examinations and hardness measurements. Additionally, the joint cross-section was examined by destructive testing methods to enable precise determination of the internal defects and imperfections. The surface methods were applied again, this time to determine the severity of welding defects. The analysis has proved that, fabricated under proper conditions and with parameters of the welding process duly observed, the welded joint has good properties and repairs of this type are possible in practice.

  12. 20 The Tools - 03 Self-Efficacy Questionnaires - TfLN Self-Efficacy Questionnaires: Rationale (01 Guide to Self-Efficacy)

    OpenAIRE

    TfLN-Transforming Perspectives project

    2007-01-01

    Explanation of what 'self-efficacy' is taken to mean in terms of student self-perception of ability, and relating that to the literature, current academic discourse and the use of the term in the TfLN context.

  13. Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-κB axis.

    Science.gov (United States)

    Cirillo, Plinio; Conte, Stefano; Pellegrino, Grazia; Ziviello, Francesca; Barra, Giusi; De Palma, Raffaele; Leonardi, Antonio; Trimarco, Bruno

    2016-08-01

    Pregnancy-associated plasma protein-A (PAPP-A) is a metalloproteinase with a controversial role in pathophysiology of cardiovascular disease. It seems involved in progression of atherosclerosis and is widely represented in atherosclerotic plaque. PAPP-A plasma levels are elevated in patients with acute coronary syndromes (ACS), thus it has been suggested that it might be a prognostic marker for developing major cardiovascular events. However, the pathophysiological link(s) between PAPP-A and ACS are still unknown. Several studies have indicated that tissue factor (TF) plays a pivotal role in the pathophysiology of ACS by triggering the formation of intracoronary thrombi following endothelial injury. This study investigates whether PAPP-A, at concentrations measurable in ACS patients, might induce TF expression in human endothelial cells in culture (HUVEC). In HUVEC, PAPP-A induced TF-mRNA transcription as demonstrated by real time PCR and expression of functionally active TF as demonstrated by FACS analysis and pro-coagulant activity assay. PAPP-A induced TF expression through the activation of Akt/NF-κB axis, as demonstrated by luciferase assay and by suppression of TF-mRNA transcription as well as of TF expression/activity by Akt and NF-κB inhibitors. These data indicate that PAPP-A promotes TF expression in human endothelial cells and support the hypothesis that this proteinase, besides being involved in progression of atherosclerosis, does not represent an independent risk factor for adverse cardiovascular events, but it rather might play an "active" role in the pathophysiology of ACS as an effector molecule able to induce a pro-thrombotic phenotype in endothelial cells.

  14. Development of burnup dependent fuel rod model in COBRA-TF

    Science.gov (United States)

    Yilmaz, Mine Ozdemir

    The purpose of this research was to develop a burnup dependent fuel thermal conductivity model within Pennsylvania State University, Reactor Dynamics and Fuel Management Group (RDFMG) version of the subchannel thermal-hydraulics code COBRA-TF (CTF). The model takes into account first, the degradation of fuel thermal conductivity with high burnup; and second, the fuel thermal conductivity dependence on the Gadolinium content for both UO2 and MOX fuel rods. The modified Nuclear Fuel Industries (NFI) model for UO2 fuel rods and Duriez/Modified NFI Model for MOX fuel rods were incorporated into CTF and fuel centerline predictions were compared against Halden experimental test data and FRAPCON-3.4 predictions to validate the burnup dependent fuel thermal conductivity model in CTF. Experimental test cases from Halden reactor fuel rods for UO2 fuel rods at Beginning of Life (BOL), through lifetime without Gd2O3 and through lifetime with Gd 2O3 and a MOX fuel rod were simulated with CTF. Since test fuel rod and FRAPCON-3.4 results were based on single rod measurements, CTF was run for a single fuel rod surrounded with a single channel configuration. Input decks for CTF were developed for one fuel rod located at the center of a subchannel (rod-centered subchannel approach). Fuel centerline temperatures predicted by CTF were compared against the measurements from Halden experimental test data and the predictions from FRAPCON-3.4. After implementing the new fuel thermal conductivity model in CTF and validating the model with experimental data, CTF model was applied to steady state and transient calculations. 4x4 PWR fuel bundle configuration from Purdue MOX benchmark was used to apply the new model for steady state and transient calculations. First, one of each high burnup UO2 and MOX fuel rods from 4x4 matrix were selected to carry out single fuel rod calculations and fuel centerline temperatures predicted by CTF/TORT-TD were compared against CTF /TORT-TD /FRAPTRAN

  15. mCRP triggers angiogenesis by inducing F3 transcription and TF signalling in microvascular endothelial cells.

    Science.gov (United States)

    Peña, Esther; de la Torre, Raquel; Arderiu, Gemma; Slevin, Mark; Badimon, Lina

    2017-01-26

    Inflammation contributes to vascular disease progression. However, the role of circulating inflammatory molecules on microvascular endothelial cell (mECs) is not fully elucidated. The aim of this study was to investigate the effects of the short pentraxin CRP on microvascular endothelial cell angiogenic function. Subcutaneously implanted collagen plugs seeded with human mECs exposed to monomeric CRP (mCRP) in mice showed formation of an extended network of microvessels both in the plug and the overlying skin tissue, while mECs exposure to pentameric native CRP (nCRP) induced a much milder effect. To understand the mechanisms behind this angiogenic effects, mECs were exposed to both CRP forms and cell migration, wound repair and tube-like formation were investigated. nCRP effects were moderate and of slow-onset whereas mCRP induced rapid, and highly significant effects. We investigated how circulating nCRP is transformed into mCRP by confocal microscopy and western blot. nCRP is transformed into mCRP on the mECs membranes in a time dependent fashion. This transformation is specific and in part receptor dependent, and the formed mCRP triggers F3 gene transcription and TF-protein expression in mECs to induce angiogenesis. F3-silenced mECs are unable to form angiotubes. In agreement, mCRP induced upregulation of the TF signalling pathway in mECs with downstream phosphorylation of AKT and activation of the transcription factor ETS1 leading to increased CCL2 release. The circulating pentraxin nCRP with little pro-angiogenic effect when dissociated into mCRP on the surface of mECs is able to trigger potent proangiogenic effects by inducing F3-gene upregulation and TF signalling.

  16. Inhibition of Prostate Cancer Bone Metastasis by Synthetic TF Antigen Mimic/Galectin-3 Inhibitor Lactulose-l-Leucine

    Directory of Open Access Journals (Sweden)

    Olga V. Glinskii

    2012-01-01

    Full Text Available Currently incurable, prostate cancer metastasis has a remarkable ability to spread to the skeleton. Previous studies demonstrated that interactions mediated by the cancer-associated Thomsen-Friedenreich glycoantigen (TF-Ag and the carbohydrate-binding protein galectin-3 play an important role in several rate-limiting steps of cancer metastasis such as metastatic cell adhesion to bone marrow endothelium, homotypic tumor cell aggregation, and clonogenic survival and growth. This study investigated the ability of a synthetic small-molecular-weight nontoxic carbohydrate-based TF-Ag mimic lactulose-l-leucine (Lac-l-Leu to inhibit these processes in vitro and, ultimately, prostate cancer bone metastasis in vivo. Using an in vivo mouse model, based on intracardiac injection of human PC-3 prostate carcinoma cells stably expressing luciferase, we investigated the ability of Lac-l-Leu to impede the establishment and growth of bone metastasis. Parallel-flow chamber assay, homotypic aggregation assay, modified Boyden chamber assay, and clonogenic growth assay were used to assess the effects of Lac-l-Leu on tumor cell adhesion to the endothelium, homotypic tumor cell aggregation, transendothelial migration, and clonogenic survival and growth, respectively. We report that daily intraperitoneal administration of Lac-l-Leu resulted in a three-fold (P < .05 decrease in metastatic tumor burden compared with the untreated control. Mechanistically, the effect of Lac-l-Leu, which binds and inhibits galectins by mimicking essential structural features of the TF-Ag, was associated with a dose-dependent inhibition of prostate cancer cell adhesion to bone marrow endothelium, homotypic aggregation, transendothelial migration, and clonogenic growth. We conclude that small-molecular-weight carbohydrate-based compounds targeting β-galactoside-mediated interactions could provide valuable means for controlling and preventing metastatic prostate cancer spread to the skeleton.

  17. TETIG diagrams - a new way to optimise the design parameters and heat treatment of joints made in high-temperature brazing alloys. [LMFBR

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R. (UKAEA Springfields Nuclear Power Development Labs.)

    1982-12-01

    The applications and problems of brazing are reviewed. Phase studies with the braze filler metal chosen for the LMFBR 9% Cr 1% Mo tube-in-tube joint work (BNi4), are discussed, with special reference to the problem of how to eliminate the centre-line eutectics containing hard, brittle compounds. A TETIG diagram is explained with reference to the variables (1) temperature of brazing operation; (2) time of soaking at temperature; and (3) the gap within the joints. Experiments are reported on brazing specimens of AISI 321 stainless steel, using braze filler metals containing various proportions of boron and silicon as the melting point temperature depressant. TETIG diagrams are constructed and used to predict how to optimize further joints. Micrographs show the effects of the variables on the microstructures.

  18. Architectural and structural qualities in timber joints

    DEFF Research Database (Denmark)

    Christensen, Jesper Thøger; Christensen, Mogens Fiil; Damkilde, Lars

    2016-01-01

    design phase. The result is joints that function structurally but do not add value to the design, and may even compromise the architectural ideas. With an approach, integrating both structural and architectural design from the beginning, one should not only gain better structures and architecture...... but also increase timbers competitiveness in the building industry. The paper is part of an ongoing research project aiming at providing tools for an integrated design process for timber structures. The focus of the paper is to identify how structure and its joints contributes to architecture and vice...... versa. Further, a method for how to design with structure and joints from the very early stage of design is proposed. The architectural/engineering model of the joints will later be incorporated in the digital design environment of the designer. In this way, the conceptual design phase will not only...

  19. Joint torques and dynamic joint stiffness in elderly and young men during stepping down

    NARCIS (Netherlands)

    Lark, S.D.; Buckley, J.G.; Bennett, S.; Jones, D.A.; Sargeant, A.J.

    2003-01-01

    Objective. To compare the joint torque pattern and dynamic joint stiffness at the knee and ankle in elderly and young men during stepping down. Background. Adequate joint stiffness is critical during the single support phase to control forward and downward body momentum. Design. Six active elderly

  20. 46 CFR 56.30-3 - Piping joints (reproduces 110).

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Piping joints (reproduces 110). 56.30-3 Section 56.30-3... APPURTENANCES Selection and Limitations of Piping Joints § 56.30-3 Piping joints (reproduces 110). The type of piping joint used shall be suitable for the design conditions and shall be selected with consideration of...

  1. The Coupling Fields Characteristics of Cable Joints and Application in the Evaluation of Crimping Process Defects

    Directory of Open Access Journals (Sweden)

    Fan Yang

    2016-11-01

    Full Text Available The internal defects of cable joints always accelerate the deterioration of insulation, until finally accidents can arise due to the explosion of the joints. The formation process of this damage often involves changes in the electromagnetic, temperature and stress distribution of the cable joint, therefore, it is necessary to analyze the electromagnetic-thermal-mechanical distribution of cable joints. Aiming at solving this problem, the paper sets up a 3-D electromagnetic-thermal-mechanical coupling model of cable joints under crimping process defects. Based on the model, the electromagnetic losses distribution, temperature distribution and stress distribution of a cable joint and body are calculated. Then, the coupling fields characteristics in different contact coefficient k, ambient temperature Tamb and load current I were analyzed, and according to the thermal-mechanical characteristics of a cable joint under internal defects, the temperature difference ΔTf and stress difference Δσf of cable surface are applied to evaluate the internal cable joint defects. Finally, a simplified model of the cable joint is set up to verify the accuracy of the coupling field model proposed in this paper, which indicates that the model can be used to analyze the coupling fields characteristics of cable joints and the method can be applied to evaluate crimping process defects of cable joints.

  2. Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3

    Directory of Open Access Journals (Sweden)

    Chia-Nan Chen

    2005-01-01

    Full Text Available SARS-CoV is the causative agent of severe acute respiratory syndrome (SARS. The virally encoded 3C-like protease (3CLPro has been presumed critical for the viral replication of SARS-CoV in infected host cells. In this study, we screened a natural product library consisting of 720 compounds for inhibitory activity against 3CLPro. Two compounds in the library were found to be inhibitive: tannic acid (IC50 = 3 µM and 3-isotheaflavin-3-gallate (TF2B (IC50 = 7 µM. These two compounds belong to a group of natural polyphenols found in tea. We further investigated the 3CLPro-inhibitory activity of extracts from several different types of teas, including green tea, oolong tea, Puer tea and black tea. Our results indicated that extracts from Puer and black tea were more potent than that from green or oolong teas in their inhibitory activities against 3CLPro. Several other known compositions in teas were also evaluated for their activities in inhibiting 3CLPro. We found that caffeine, (—-epigallocatechin gallte (EGCg, epicatechin (EC, theophylline (TP, catechin (C, epicatechin gallate (ECg and epigallocatechin (EGC did not inhibit 3CLPro activity. Only theaflavin-3,3′-digallate (TF3 was found to be a 3CLPro inhibitor. This study has resulted in the identification of new compounds that are effective 3CLPro inhibitors.

  3. Joint mobilization.

    Science.gov (United States)

    Saunders, Deborah Gross; Walker, J Randy; Levine, David

    2005-11-01

    Therapeutic touch has been used in human beings to soothe aches and pains. Most dogs also seem to enjoy being touched. Manual therapy techniques are skilled hand movements intended to improve tissue extensibility; increase range of motion; induce relaxation; mobilize or manipulate soft tissue and joints; modulate pain; and reduce soft tissue swelling, inflammation, or restriction. The intent of this article is to provide an overview of the principles of manual therapy, followed by selected treatment techniques for the hip, stifle, elbow, shoulder, carpus.and thoracic and lumbar spine. The techniques of G.D. Maitland, an Australian physical therapist who developed a clinically based approach in the 1960s and 1970s, are emphasized.

  4. [TfR2 mRNA expression in bone marrow mononuclear cells of children with hyperplastic anemia and its implications].

    Science.gov (United States)

    Chen, Ting-Ting; Yuan, Li-Xing; Pan, Ling-Li; Ma, Zhi-Gui; Gu, Ling; Zhu, Yi-Ping; Gao, Ju

    2011-04-01

    The aim of this study was to investigate the expression of transferrin receptor 2 (TfR2) mRNA in bone marrow mononuclear cells (BMMNC) of children with hyperplastic anemia (HA), to analyze the correlation of TfR2 mRNA expression level with Hb level, bone marrow erythroid hyperplasia, iron status in body and underlying diseases, and to evaluate the role of TfR2 in erythroid hemopoiesis and the useful value in diagnosis of HA. The experiment was divided into 2 groups: test group, in which 40 patients with HA were enrolled, and control group in which 10 patients without erythroid disorders and hematological malignancies confirmed by bone marrow examination were enrolled. The bone marrow samples of patients in mentioned above 2 groups were collected, the TfR2 mRNA expression in BMMNC of patients with HA was detected by fluorescence-quantitative PCR, the correlation of HA with bone marrow erythroid hyperplasia, iron status of body and underlying diseases was analyzed. The results showed that the relative level of TfR2 mRNA expression in HA patients was significantly higher than that in control patients. The TfR2 mRNA expression level negatively correlated with Hb level in peripheral blood (r = -0.715), while it positively correlated with ratio of bone marrow erythroblasts (r = 0.533). It is concluded that TfR2 mRNA expression in HA patients increases and closely correlates with hyperplasia status of bone marrow and anemia level in peripheral blood.

  5. Reliability of Tubular Joints

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Thoft-Christensen, Palle

    In this paper the preliminary results obtained by tests on tubular joints are presented. The joints are T-joints and the loading is static. It is the intention in continuation of these tests to perform tests on other types of joints (e.g. Y-joints) and also with dynamic loading. The purpose of th...

  6. Space shuttle SRM field joint: Review paper

    Directory of Open Access Journals (Sweden)

    S. Mohammad Gharouni

    2014-09-01

    Full Text Available Due to Challenger space shuttle accident in 1986, significant research has been done concerning structural behavior of field joints in solid rocket boosters (SRB. The structural deformations between the clevis inner leg and the tang (male-to-female parts of joint, the sealing of the O-ring to prevent the hot gas in joints, has been neglected causing the failure of the vehicle. Redesigning the field joint in SRB engine by accurate analysis of dynamic and thermal loads and by design of insulator and good O-ring, the leakiness of combustion hot gases was eliminated. Some parts of field joint such as capture feature (CF and its third O-ring, J-leg insulator and shim were added to redesigned field joint. Also, some adjustments in sealing system and pins were done to promote the efficiency of the field joint. Due to different experimental analysis on assembled field joints with default imperfections, redesigned joints operated well. These redesigned field joints are commonly used in aerospace and mechanical structures. This paper investigates the original and the redesigned field joints with additional explanations of different parts of the redesigned joints.

  7. Joint Replacement (Finger and Wrist Joints)

    Science.gov (United States)

    ... artificial joint Damage to vessels, nerves or other structures in the region of the surgery Alternatives Some alternate procedures for treating arthritis include: Joint injections Oral medications such as aspirin or anti-inflammatory medicines Hand therapy exercises and ...

  8. Joint x-ray

    Science.gov (United States)

    X-ray - joint; Arthrography; Arthrogram ... x-ray technologist will help you position the joint to be x-rayed on the table. Once in place, pictures are taken. The joint may be moved into other positions for more ...

  9. Agrobacterium tumefaciens-mediated transformation of plants by the pTF-FC2 plasmid is efficient and strictly dependent on the MobA protein.

    Science.gov (United States)

    Dube, Thabani; Kovalchuk, Igor; Hohn, Barbara; Thomson, Jennifer A

    2004-07-01

    In the transformation of plants by Agrobacterium tumefaciens the VirD2 protein has been shown to pilot T-DNA during its transfer to the plant cell nucleus. Other studies have shown that the MobA protein of plasmid RSF1010 is capable of mediating its transfer from Agrobacterium cells to plant cells by a similar process. We have demonstrated previously that plasmid pTF-FC2, which has some similarity to RSF1010, is also able to transfer DNA efficiently. In this study, we performed a mutational analysis of the roles played by A . tumefaciens VirD2 and pTF-FC2 MobA in DNA transfer-mediated by A. tumefaciens carrying pTF-FC2. We show that MobA+/VirD2+ and MobA+/VirD2- strains were equally proficient in their ability to transfer a pTF-FC2-derived plasmid DNA to plants and to transform them. However, the MobA-/VirD2+ strain showed a DNA transfer efficiency of 0.03% compared with that of the other two strains. This sharply contrasts with our results that VirD2 can rather efficiently cleave the oriT sequence of pFT-FC2 in vitro . We therefore conclude that MobA plays a major VirD2-independent role in plant transformation by pTF-FC2.

  10. Evaluation of base material and welded joints designated for membrane wall components made from low-alloy steels in large boilermaker conditions

    Energy Technology Data Exchange (ETDEWEB)

    Dobrzanski, Janusz; Zielinski, Adam [Institute for Ferrous Metallurgy, Gliwice (Poland); Pasternak, Jerzy [Boiler Engineering Company RAFAKO S.A., Raciborz (Poland)

    2010-07-01

    Supercritical operating parameters of lower emission power units require novel creep resisting steels. Therefore, this paper constains selected information, results of collectors made from the new low-alloy bainitic creep-resistant steels as 7CrWVNb9-6(P23) and 7CrMoVTiB10-10(P24) performed in large boilermaker conditions. The research and implementation process includes: - evaluation, comparison of requested properties of base material and welded joints as tensile strength, impact strength and technological properties, - destructive examinations with evaluation of welded joints and HAZ structure and hardness distribution, - evaluation of creep resistance properties and structure stability after heat treatments and again process of base material, HAZ and welded joints, - influence of manufacturing process in large boilermaker conditions and after simulated operation. A new creep-resistant steels to be used, in order to comply with the operational requirements, as to assure the appropriate reliability and safety of the boiler equipment in operation process. (orig.)

  11. Numerical rigid plastic modelling of shear capacity of keyed joints

    DEFF Research Database (Denmark)

    Herfelt, Morten Andersen; Poulsen, Peter Noe; Hoang, Linh Cao

    2015-01-01

    Keyed shear joints are currently designed using simple and conservative design formulas, yet these formulas do not take the local mechanisms in the concrete core of the joint into account. To investigate this phenomenon a rigid, perfectly plastic finite element model of keyed joints is used. The ...

  12. COMBINED MEASUREMENTS WITH THREE-DIMENSIONAL DESIGN INFORMATION VERIFICATION SYSTEM AND GAMMA RAY IMAGING - A COLLABORATIVE EFFORT BETWEEN OAK RIDGE NATIONAL LABORATORY, LAWRENCE LIVERMORE NATIONAL LABORATORY, AND THE JOINT RESEARCH CENTER AT ISPRA

    Energy Technology Data Exchange (ETDEWEB)

    Mihailescu, L; Vetter, K; Ruhter, W; Chivers, D; Dreicer, M; Coates, C; Smith, S; Hines, J; Caiado, A R; Sequeira, V; Fiocco, M; Goncalves, J G

    2006-06-14

    Oak Ridge National Laboratory (ORNL) and Lawrence Livermore National Laboratory (LLNL) have jointly performed tests to demonstrate combined measurements with a three-dimensional (3D) design information verification (DIV) system and a gamma-ray imager for potential safeguard applications. The 3D DIV system was made available by the European Commission's Joint Research Center to ORNL under a collaborative project between the U.S. Department of Energy and the European Atomic Energy Community (EURATOM). The system is able to create 3D maps of rooms and objects and of identifying changes in positions and modifications with a precision on the order of millimeters. The gamma ray imaging system consists of a 4{pi} field-of-view Compton imaging system which has two fully operational DSSD (Double-Sided Segment Detector) High-Purity Germanium (HPGe) detectors developed at LLNL. The Compton imaging instrument not only provides imaging capabilities, but provides excellent energy resolution which enables the identification of radioisotopes and nuclear materials. Joint Research Center was responsible to merge gamma-ray images with the 3D range maps. The results of preliminary first measurements performed at LLNL demonstrate, for the first time, mapping of panoramic gamma-ray images into 3D range data.

  13. European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95).

    Science.gov (United States)

    Poller, L; Keown, M; Chauhan, N; van den Besselaar, A M H P; Tripodi, A; Shiach, C; Jespersen, J

    2005-06-01

    A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is significantly greater than the mean ISI of 0.94 obtained previously. The change in ISI for international reference preparation (IRP) rTF/95 relative to RBT/90 would lead to a slight bias in INR for human compared with rabbit thromboplastins. At a theoretical INR of 3.0, the INR bias is 6.0%, and this is below the accepted 10% level of clinical relevance. Ongoing stability monitoring of World Health Organisation thromboplastin IRP is advised.

  14. Alteration of a single nucleotide allows efficient binding of H2TF1/KBF1 to the immunoglobulin kappa enhancer B motif.

    Science.gov (United States)

    Mauxion, F; Sen, R

    1989-08-01

    NF-kappa B (a protein present constitutively only in B cells) and H2TF1/KBF1 (a more ubiquitously distributed protein[s]) are two transcription factors that recognize very similar DNA sequences. However, the binding site associated with the kappa immunoglobulin gene enhancer (kappa B) is recognized predominantly by NF-kappa B. Using synthetically altered recognition sequences, we showed that the B-cell-specific NF-kappa B-binding site in the kappa enhancer can be converted to one that binds both NF-kappa B and the ubiquitous protein(s) H2TF1/KBF1 by substitution of a single nucleotide. Furthermore, transient transfection experiments suggested that NF-kappa B and H2TF1/KBF1 are functionally different even though their DNA recognition specificities are very similar.

  15. Hallux interphalangeal joint range of motion in feet with and without limited first metatarsophalangeal joint dorsiflexion.

    Science.gov (United States)

    Munuera, Pedro V; Trujillo, Piedad; Güiza, Israel

    2012-01-01

    This work was designed to assess the degree of correlation between hallux interphalangeal joint and first metatarsophalangeal joint dorsiflexion and to compare the mobility of the hallux interphalangeal joint between participants with and without limited first metatarsophalangeal joint dorsiflexion (hallux limitus). Dorsiflexion of the hallux interphalangeal joint was measured in 60 normal feet and in 60 feet with hallux limitus to find correlations with first metatarsophalangeal joint dorsiflexion with the Spearman correlation coefficient and a simple linear regression equation. In addition, movement of the hallux interphalangeal joint was compared between normal and hallux limitus feet with the Mann-Whitney U test. Significant differences were found between the groups in mean ± SD interphalangeal joint dorsiflexion (control group: 1.17° ± 2.50° ; hallux limitus group: 10.65° ± 8.24° ; P dorsiflexion and hallux interphalangeal joint dorsiflexion (ρ = -0.766, P dorsiflexion = 27.17 - 0.381 × first metatarsophalangeal joint dorsiflexion. Hallux interphalangeal joint dorsiflexion was greater in feet with hallux limitus than in normal feet. There was a strong inverse correlation between first metatarsophalangeal joint dorsiflexion and hallux interphalangeal joint dorsiflexion.

  16. Dielectric relaxation and ultrafast transient absorption spectroscopy of [C6mim]+[Tf2N]−/acetonitrile mixtures.

    Science.gov (United States)

    Lohse, Peter W; Bartels, Nils; Stoppa, Alexander; Buchner, Richard; Lenzer, Thomas; Oum, Kawon

    2012-03-14

    Mixtures of the ionic liquid (IL) [C(6)mim](+)[Tf(2)N](-) and acetonitrile have been investigated by a combination of dielectric relaxation spectroscopy (DRS) and ultrafast transient absorption techniques using the molecular probe 12'-apo-β-carotenoic-12'-acid (12'CA). Steady-state absorption spectra of the 12'CA molecule have also been recorded. The position of the probe's S(0)→ S(2) absorption maximum correlates linearly with the polarizability of the mixture, suggesting that the bulk composition is a good approximation to the local composition. The lifetime τ(1) of the S(1)/ICT state of 12'CA varies rather smoothly with composition between the value for pure acetonitrile (42 ps) and neat [C(6)mim](+)[Tf(2)N](-) (94 ps). At low IL contents there appears to be an influence of discrete ion pairs. Employing static dielectric constants from the DRS experiments, one finds that the lifetime of the probe in the IL mixtures is shorter than that in pure organic solvents with the same polarity parameter. This suggests an increased stabilization of the S(1)/ICT state in IL-containing mixtures, most likely due to IL-specific Coulombic interactions between the cation and the negative end of the probe's dipole. An ultrafast solvation component is observed which is ca. 0.5 ps in pure acetonitrile, and approaches the value for the pure IL (2.0 ps) already around x(IL) = 0.3. This is interpreted in terms of an efficient perturbation of the cooperative solvation response of acetonitrile by the presence of small amounts of IL and possibly also the viscosity increase when adding IL. This view is also supported by the increase of the average longitudinal relaxation time of acetonitrile upon addition of small IL amounts extracted from the DRS experiments.

  17. Single-Nucleotide-Specific Targeting of the Tf1 Retrotransposon Promoted by the DNA-Binding Protein Sap1 of Schizosaccharomyces pombe.

    Science.gov (United States)

    Hickey, Anthony; Esnault, Caroline; Majumdar, Anasuya; Chatterjee, Atreyi Ghatak; Iben, James R; McQueen, Philip G; Yang, Andrew X; Mizuguchi, Takeshi; Grewal, Shiv I S; Levin, Henry L

    2015-11-01

    Transposable elements (TEs) constitute a substantial fraction of the eukaryotic genome and, as a result, have a complex relationship with their host that is both adversarial and dependent. To minimize damage to cellular genes, TEs possess mechanisms that target integration to sequences of low importance. However, the retrotransposon Tf1 of Schizosaccharomyces pombe integrates with a surprising bias for promoter sequences of stress-response genes. The clustering of integration in specific promoters suggests that Tf1 possesses a targeting mechanism that is important for evolutionary adaptation to changes in environment. We report here that Sap1, an essential DNA-binding protein, plays an important role in Tf1 integration. A mutation in Sap1 resulted in a 10-fold drop in Tf1 transposition, and measures of transposon intermediates support the argument that the defect occurred in the process of integration. Published ChIP-Seq data on Sap1 binding combined with high-density maps of Tf1 integration that measure independent insertions at single-nucleotide positions show that 73.4% of all integration occurs at genomic sequences bound by Sap1. This represents high selectivity because Sap1 binds just 6.8% of the genome. A genome-wide analysis of promoter sequences revealed that Sap1 binding and amounts of integration correlate strongly. More important, an alignment of the DNA-binding motif of Sap1 revealed integration clustered on both sides of the motif and showed high levels specifically at positions +19 and -9. These data indicate that Sap1 contributes to the efficiency and position of Tf1 integration. Copyright © 2015 by the Genetics Society of America.

  18. Structural modelling and molecular dynamics of a multi-stress responsive WRKY TF-DNA complex towards elucidating its role in stress signalling mechanisms in chickpea.

    Science.gov (United States)

    Konda, Aravind Kumar; Farmer, Rohit; Soren, Khela Ram; P S, Shanmugavadivel; Setti, Aravind

    2017-07-28

    Chickpea is a premier food legume crop with high nutritional quality and attains prime importance in the current era of 795 million people being undernourished worldwide. Chickpea production encounters setbacks due to various stresses and understanding the role of key transcription factors (TFs) involved in multiple stresses becomes inevitable. We have recently identified a multi-stress responsive WRKY TF in chickpea. The present study was conducted to predict the structure of WRKY TF to identify the DNA-interacting residues and decipher DNA-protein interactions. Comparative modelling approach produced 3D model of the WRKY TF with good stereochemistry, local/global quality and further revealed W19, R20, K21, and Y22 motifs within a vicinity of 5 Å to the DNA amongst R18, G23, Q24, K25, Y36, Y37, R38 and K47 and these positions were equivalent to the 2LEX WRKY domain of Arabidopsis. Molecular simulations analysis of reference protein -PDB ID 2LEX, along with Car-WRKY TF modelled structure with the DNA coordinates derived from PDB ID 2LEX and docked using HADDOCK were executed. Root Mean Square (RMS) Deviation and RMS Fluctuation values yielded consistently stable trajectories over 50 ns simulation. Strengthening the obtained results, neither radius of gyration, distance and total energy showed any signs of DNA-WRKY complex falling apart nor any significant dissociation event over 50 ns run. Therefore, the study provides first insights into the structural properties of multi-stress responsive WRKY TF-DNA complex in chickpea, enabling genome wide identification of TF binding sites and thereby deciphers their gene regulatory networks.

  19. European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)

    OpenAIRE

    Poller, L.; Keown, M; Chauhan, N.; van den Besselaar, A M H P; Tripodi, A.; Shiach, C; Jespersen, J

    2005-01-01

    A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is significantly greater than the mean ISI of 0.94 obtained previously. The change in ISI for international r...

  20. On the coordination of Zn2+ion in Tf2N-based ionic liquids: structural and dynamic properties depending on the nature of the organic cation.

    Science.gov (United States)

    Sessa, Francesco; Migliorati, Valentina; Serva, Alessandra; Lapi, Andrea; Aquilanti, Giuliana; Mancini, Giordano; D'Angelo, Paola

    2018-01-24

    A synergic approach combining molecular dynamics (MD) simulations and X-ray absorption spectroscopy has been used to investigate diluted solutions of zinc bis(trifluoromethanesulfonyl)imide (Zn(Tf 2 N) 2 ) in Tf 2 N - based ionic liquids (ILs) having different organic cations, namely the 1-butyl-3-methylimidazolium ([C 4 (mim)] + ), 1,8-bis(3-methylimidazolium-1-yl)octane ([C 8 (mim) 2 ] 2+ ), N,N,N-trimethyl-N-(2-hydroxyethyl)ammonium ([Choline] + ) and butyltrimethylammonium ([BTMA] + ) ions. All of the ILs tend to dissolve the Zn(Tf 2 N) 2 species giving rise to a different structural arrangement around the Zn 2+ as compared to that of the salt crystallographic structure. A quantitative analysis of the Zn K-edge extended X-ray absorption fine structure (EXAFS) spectra of the solutions has been carried out based on the microscopic description of the systems derived from the MD simulations. A very good agreement between theoretical and experimental EXAFS signals has been obtained, allowing us to assess the reliability of the MD structural results for all the investigated solutions. The Zn 2+ ion has been shown to be coordinated by six oxygen atoms of the Tf 2 N - anions arranged in an octahedral geometry in all the Tf 2 N - based ILs, regardless of the organic cation of the IL solvent. However, the nature of the organic cation has a small influence on the overall spatial arrangement of the Tf 2 N - anions in the Zn 2+ first solvation shell: two different Zn-Tf 2 N complexes are found in solution, a 5-fold one, with one bidentate and four monodentate Tf 2 N - anions, and a 6-fold one with only monodentate ligands, with the ratio between the two species being slightly dependent on the IL cation. The IL ion three-dimensional arrangements in the different IL solutions were also investigated by carrying out a thorough analysis of the MD simulations, highlighting similarities and differences between imidazolium and ammonium based IL systems.

  1. Estimation of Fatigue Life of Laser Welded AISI304 Stainless Steel T-Joint Based on Experiments and Recommendations in Design Codes

    DEFF Research Database (Denmark)

    Lambertsen, Søren Heide; Damkilde, Lars; Kristensen, Anders Schmidt

    2013-01-01

    of specimens are used, two of these are non-welded and the third is welded with a transverse welding (T-Joint). The 13 laser welded specimens are cut out with a milling cutter. The non-welded specimens are divided in 13 specimens cut out with a milling cutter and 10 specimens cut out by a plasma cutter......In this paper the fatigue behavior of laser welded T-joints of stainless steel AISI304 is investigated experimentally. In the fatigue experiments 36 specimens with a sheet thickness of 1 mm are exposed to one-dimensional cyclic loading. Three different types of specimens are adopted. Three groups....... The non-welded specimens are used to study the influence of heat and surface effects on the fatigue life. The fatigue life from the experiments is compared to fatigue life calculated from the guidelines in the standards DNV-RP-C203 and EUROCODE 3 EN-1993-1-9. Insignificant differences in fatigue life...

  2. Joint Force Quarterly. Number 5, Summer 1994

    Science.gov (United States)

    1994-07-01

    Editor The Typography and Design Division of the U.S. Government Printing Office is responsible for layout and art direction. Joint Force Quarterly is... menu of joint space force options whose stated purpose is to ensure overall U.S. space superiority. All the services look to the near future when space

  3. Behaviour of high strength steel moment joints

    NARCIS (Netherlands)

    Girão Coelho, A.M.; Bijlaard, F.S.K.

    2010-01-01

    The design of joints to European standard EN 1993 within the semi-continuous/partially restrained philosophy is restricted to steel grades up to S460. With the recent development of high performance steels, the need for these restrictions should be revisited. The semicontinuous joint modelling can

  4. Joint Route Planning under Varying Market Conditions

    NARCIS (Netherlands)

    Cruijssen, F.C.A.M.; Braysy, O.; Dullaert, W.; Fleuren, H.A.; Salomon, M.

    2006-01-01

    Purpose - To provide empirical evidence on the level of savings that can be attained by joint route planning and how these savings depend on specific market characteristics.Design/methodology/approach - Joint route planning is a measure that companies can take to decrease the costs of their

  5. Cooperative Engineering as a Joint Action

    Science.gov (United States)

    Joffredo-Le Brun, Sophie; Morellato, Mireille; Sensevy, Gérard; Quilio, Serge

    2018-01-01

    This paper describes some elements of a specific kind of design-based research, cooperative engineering. In the first part of the paper, we argue that cooperative engineering can be analyzed through a joint action framework. We first present some conceptual tools that the Joint Action Theory in Didactics proposes in order to understand didactic…

  6. Durability of building joint sealants

    Science.gov (United States)

    Christopher C. White; Kar Tean Tan; Donald L. Hunston; R. Sam Williams

    2009-01-01

    Predicting the service life of building joint sealants exposed to service environments in less than real time has been a need of the sealant community for many decades. Despite extensive research efforts to design laboratory accelerated tests to duplicate the failure modes occurring in field exposures, little success has been achieved using conventional durability...

  7. CLIP-GENE: a web service of the condition specific context-laid integrative analysis for gene prioritization in mouse TF knockout experiments.

    Science.gov (United States)

    Hur, Benjamin; Lim, Sangsoo; Chae, Heejoon; Seo, Seokjun; Lee, Sunwon; Kang, Jaewoo; Kim, Sun

    2016-10-24

    Transcriptome data from the gene knockout experiment in mouse is widely used to investigate functions of genes and relationship to phenotypes. When a gene is knocked out, it is important to identify which genes are affected by the knockout gene. Existing methods, including differentially expressed gene (DEG) methods, can be used for the analysis. However, existing methods require cutoff values to select candidate genes, which can produce either too many false positives or false negatives. This hurdle can be addressed either by improving the accuracy of gene selection or by providing a method to rank candidate genes effectively, or both. Prioritization of candidate genes should consider the goals or context of the knockout experiment. As of now, there are no tools designed for both selecting and prioritizing genes from the mouse knockout data. Hence, the necessity of a new tool arises. In this study, we present CLIP-GENE, a web service that selects gene markers by utilizing differentially expressed genes, mouse transcription factor (TF) network, and single nucleotide variant information. Then, protein-protein interaction network and literature information are utilized to find genes that are relevant to the phenotypic differences. One of the novel features is to allow researchers to specify their contexts or hypotheses in a set of keywords to rank genes according to the contexts that the user specify. We believe that CLIP-GENE will be useful in characterizing functions of TFs in mouse experiments. http://epigenomics.snu.ac.kr/CLIP-GENE REVIEWERS: This article was reviewed by Dr. Lee and Dr. Pongor.

  8. The analysis of adhesively bonded advanced composite joints using joint finite elements

    Science.gov (United States)

    Stapleton, Scott E.

    The design and sizing of adhesively bonded joints has always been a major bottleneck in the design of composite vehicles. Dense finite element (FE) meshes are required to capture the full behavior of a joint numerically, but these dense meshes are impractical in vehicle-scale models where a course mesh is more desirable to make quick assessments and comparisons of different joint geometries. Analytical models are often helpful in sizing, but difficulties arise in coupling these models with full-vehicle FE models. Therefore, a joint FE was created which can be used within structural FE models to make quick assessments of bonded composite joints. The shape functions of the joint FE were found by solving the governing equations for a structural model for a joint. By analytically determining the shape functions of the joint FE, the complex joint behavior can be captured with very few elements. This joint FE was modified and used to consider adhesives with functionally graded material properties to reduce the peel stress concentrations located near adherend discontinuities. Several practical concerns impede the actual use of such adhesives. These include increased manufacturing complications, alterations to the grading due to adhesive flow during manufacturing, and whether changing the loading conditions significantly impact the effectiveness of the grading. An analytical study is conducted to address these three concerns. Furthermore, proof-of-concept testing is conducted to show the potential advantages of functionally graded adhesives. In this study, grading is achieved by strategically placing glass beads within the adhesive layer at different densities along the joint. Furthermore, the capability to model non-linear adhesive constitutive behavior with large rotations was developed, and progressive failure of the adhesive was modeled by re-meshing the joint as the adhesive fails. Results predicted using the joint FE was compared with experimental results for various

  9. The Analysis of Adhesively Bonded Advanced Composite Joints Using Joint Finite Elements

    Science.gov (United States)

    Stapleton, Scott E.; Waas, Anthony M.

    2012-01-01

    The design and sizing of adhesively bonded joints has always been a major bottleneck in the design of composite vehicles. Dense finite element (FE) meshes are required to capture the full behavior of a joint numerically, but these dense meshes are impractical in vehicle-scale models where a course mesh is more desirable to make quick assessments and comparisons of different joint geometries. Analytical models are often helpful in sizing, but difficulties arise in coupling these models with full-vehicle FE models. Therefore, a joint FE was created which can be used within structural FE models to make quick assessments of bonded composite joints. The shape functions of the joint FE were found by solving the governing equations for a structural model for a joint. By analytically determining the shape functions of the joint FE, the complex joint behavior can be captured with very few elements. This joint FE was modified and used to consider adhesives with functionally graded material properties to reduce the peel stress concentrations located near adherend discontinuities. Several practical concerns impede the actual use of such adhesives. These include increased manufacturing complications, alterations to the grading due to adhesive flow during manufacturing, and whether changing the loading conditions significantly impact the effectiveness of the grading. An analytical study is conducted to address these three concerns. Furthermore, proof-of-concept testing is conducted to show the potential advantages of functionally graded adhesives. In this study, grading is achieved by strategically placing glass beads within the adhesive layer at different densities along the joint. Furthermore, the capability to model non-linear adhesive constitutive behavior with large rotations was developed, and progressive failure of the adhesive was modeled by re-meshing the joint as the adhesive fails. Results predicted using the joint FE was compared with experimental results for various

  10. Space shuttle SRM field joint: Review paper

    OpenAIRE

    S. Mohammad Gharouni; Hamid M. Panahiha; Jafar Eskandari Jam

    2014-01-01

    Due to Challenger space shuttle accident in 1986, significant research has been done concerning structural behavior of field joints in solid rocket boosters (SRB). The structural deformations between the clevis inner leg and the tang (male-to-female parts of joint), the sealing of the O-ring to prevent the hot gas in joints, has been neglected causing the failure of the vehicle. Redesigning the field joint in SRB engine by accurate analysis of dynamic and thermal loads and by design of insula...

  11. Design

    DEFF Research Database (Denmark)

    Volf, Mette

    This publication is unique in its demystification and operationalization of the complex and elusive nature of the design process. The publication portrays the designer’s daily work and the creative process, which the designer is a part of. Apart from displaying the designer’s work methods...... and design parameters, the publication shows examples from renowned Danish design firms. Through these examples the reader gets an insight into the designer’s reality....

  12. TF-finder: A software package for identifying transcription factors involved in biological processes using microarray data and existing knowledge base

    Directory of Open Access Journals (Sweden)

    Cui Xiaoqi

    2010-08-01

    Full Text Available Abstract Background Identification of transcription factors (TFs involved in a biological process is the first step towards a better understanding of the underlying regulatory mechanisms. However, due to the involvement of a large number of genes and complicated interactions in a gene regulatory network (GRN, identification of the TFs involved in a biology process remains to be very challenging. In reality, the recognition of TFs for a given a biological process can be further complicated by the fact that most eukaryotic genomes encode thousands of TFs, which are organized in gene families of various sizes and in many cases with poor sequence conservation except for small conserved domains. This poses a significant challenge for identification of the exact TFs involved or ranking the importance of a set of TFs to a process of interest. Therefore, new methods for recognizing novel TFs are desperately needed. Although a plethora of methods have been developed to infer regulatory genes using microarray data, it is still rare to find the methods that use existing knowledge base in particular the validated genes known to be involved in a process to bait/guide discovery of novel TFs. Such methods can replace the sometimes-arbitrary process of selection of candidate genes for experimental validation and significantly advance our knowledge and understanding of the regulation of a process. Results We developed an automated software package called TF-finder for recognizing TFs involved in a biological process using microarray data and existing knowledge base. TF-finder contains two components, adaptive sparse canonical correlation analysis (ASCCA and enrichment test, for TF recognition. ASCCA uses positive target genes to bait TFS from gene expression data while enrichment test examines the presence of positive TFs in the outcomes from ASCCA. Using microarray data from salt and water stress experiments, we showed TF-finder is very efficient in recognizing

  13. Butt Joint Tool Commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N N

    2007-12-06

    ITER Central Solenoid uses butt joints for connecting the pancakes in the CS module. The principles of the butt joining of the CICC were developed by the JAPT during CSMC project. The difference between the CSMC butt joint and the CS butt joint is that the CS butt joint is an in-line joint, while the CSMC is a double joint through a hairpin jumper. The CS butt joint has to carry the hoop load. The straight length of the joint is only 320 mm, and the vacuum chamber around the joint has to have a split in the clamp shell. These requirements are challenging. Fig.1 presents a CSMC joint, and Fig.2 shows a CS butt joint. The butt joint procedure was verified and demonstrated. The tool is capable of achieving all specified parameters. The vacuum in the end was a little higher than the target, which is not critical and readily correctable. We consider, tentatively that the procedure is established. Unexpectedly, we discover significant temperature nonuniformity in the joint cross section, which is not formally a violation of the specs, but is a point of concern. All testing parameters are recorded for QA purposes. We plan to modify the butt joining tool to improve its convenience of operation and provide all features necessary for production of butt joints by qualified personnel.

  14. Avaliação do kit "TF-Test" para o diagnóstico das infecções por parasitas gastrintestinais em ovinos

    Directory of Open Access Journals (Sweden)

    Giuliano Lumina

    2006-08-01

    Full Text Available Este estudo teve como objetivos padronizar o kit TF-Test para a quantificação de ovos de parasitas gastrintestinais de ovinos e compará-lo ao método de Gordon & Whitlock modificado (G&W. Vinte quatro cordeiros confinados foram infectados artificialmente com Haemonchus contortus, durante 12 semanas, até o abate, quando foram colhidas amostras fecais e realizada a identificação e contagem dos parasitas abomasais. Nestes animais, ovos de H. contortus foram detectados em 95,8% das amostras fecais por ambos os testes (P>;0,05. Os coeficientes de correlação (r entre a carga parasitária (CP e os valores de OPG obtidos pelos métodos de G&W e TF-Test foram, respectivamente, de r=0,52 e r=0,51 (dados não transformados e r=0,85 e r=0,87 (dados transformados em log. Outras 100 amostras fecais foram colhidas de ovinos naturalmente infectados. Nas amostras destes animais, os testes G&W e TF-Test propiciaram o diagnóstico de ovos de estrongilídeos em 85% e 86% das amostras, respectivamente (P>;0,05. Pelo TF-Test e pelo G&W, oocistos de Eimeria foram detectados em 33% e em 12% das amostras (P<0,001 e ovos de Strongyloides spp. em 15% e 5% das amostras, respectivamente (P<0,05. Ambos os testes foram precisos para o diagnóstico de estrongilídeos gastrintestinais, porém, o TF-Test foi superior para o diagnóstico de oocistos de Eimeria spp. e de ovos de Strongyloides spp., mas, por outro lado, subestimou o número de ovos de estrongilídeos presente nas amostras.

  15. Joint Replacement (Finger and Wrist Joints)

    Science.gov (United States)

    ... alternate procedures for treating arthritis include: Joint injections Oral medications such as aspirin or anti-inflammatory medicines Hand therapy exercises and protective splints Arthrodesis surgery to fuse bones together, which relieves pain by eliminating motion be-tween damaged joint surfaces ...

  16. Neuronal correlates of asocial behavior in a BTBR T+Itpr3tf/J mouse model of autism

    Directory of Open Access Journals (Sweden)

    Ksenia Zuzanna Meyza

    2015-08-01

    Full Text Available Autism spectrum disorder (ASD is a neurodevelopmental disorder characterized, in part, by an inability to adequately respond to social cues. Patients diagnosed with ASD are often devoid of empathy and impaired in understanding other people’s emotional perspective. The neuronal correlates of this impairment are not fully understood. Replicating such behavioral phenotype in a mouse model of autism would allow us an insight into the neuronal background of the problem. Here we tested BTBR T+Itpr3tf/J (BTBR and c57BL/6J (B6 mice in two behavioral paradigms: The Transfer of Emotional Information test and the Social Proximity test. In both tests BTBR mice displayed asocial behavior. We analyzed c-Fos protein expression in several brain regions after each of these tests, to find that, unlike B6 mice, BTBR mice react to a stressed cagemate exposure in the Transfer of Emotional Information test with no increase of c-Fos expression in either the prefrontal cortex or the amygdala. After Social Proximity exposure however, we observed a strong increase in c-Fos expression in the CA3 field of hippocampus and two hypothalamic regions of BTBR brains. This response was accompanied by a strong activation of periaqueductal regions related to defensiveness, which suggests that BTBR mice find unavoidable social interaction highly aversive.

  17. Peringkasan Tweet Berdasarkan Trending Topic Twitter Dengan Pembobotan TF-IDF dan Single Linkage AngglomerativeHierarchical Clustering

    Directory of Open Access Journals (Sweden)

    Annisa Annisa

    2016-10-01

    Full Text Available Trending topic is a feature provided by twitter that informs something widely discussed by users in a particular time. The form of a trending topic is a hashtag and can be selected by clicking. However, the number of tweets for each trending topics can be very large, so it will be difficult if we want to know all the contents. So, in order to make easy when reading the topic, a small number of tweets can be selected as the main idea of the topic. In this study, we applied the Agglomerative Single Linkage Hierarchical Clustering by calculating the TF-IDF value for each word in advance. We used 100 trending topics, where each topic consists of 50 tweets in Indonesian. For testing, we provided 30 trending topics which consist of 2 until 9 sub-topics. The result is that each trending topics can be summarized into shorter text contains 2 until 9 tweets. We were able to summarize 1 trending topics exactly same as the topic summarized by human expert. However, the rest of topics corresponded partially with human expert.

  18. Preface: the role of T.F. Gorbachev State Technical University as the Flagship of Kemerovo Region Innovative Development

    Directory of Open Access Journals (Sweden)

    Krechetov Andrey

    2017-01-01

    Full Text Available Currently the Kemerovo Region is one of the most concentrated industrial agglomerations in Russia finds itself at the stage of investment modernization. This is due to the technological renovation of industries that form the core of its economy - coal, chemical, machine-building and metallurgical. The development of its human capital plays a crucial role in creating conditions for the successful innovative transformation of the regional economy. The flagship of this process is T.F. Gorbachev Kuzbass State Technical University. Alma Mater has a unique team in which creativity and experience are combined with high quality staff training for the basic branches of the regional economy and innovative activities of scientific schools, dissertation councils and the university expert community. This allows to use the existing mechanisms effectively and to create new ones for attracting external financing in all areas of activity due to the Kuzbass State Technical University scientific sector which has a significant potential for ensuring innovative development of the regional industry.

  19. Generalised joint hypermobility and knee joint hypermobility

    DEFF Research Database (Denmark)

    Junge, Tina; Henriksen, Peter; Hansen, Sebrina

    2017-01-01

    AIM: Several biomechanical factors, such as knee joint hypermobility (KJH), are suggested to play a role in the etiology of knee joint symptoms and knee osteoarthritis. Nevertheless, the prevalence or consequences of KJH solely or included in the classification of generalized joint hypermobility...... (GJHk) is unknown for a general population. Therefore, the objectives were to report the prevalence of self-reported GJHk and KJH, as well as the association of these conditions to knee joint symptoms, severity and duration of symptoms, and health-related quality of life (HRQoL) in a Danish adult...... population. METHOD: This study is a cross-sectional population-based survey of 2056 Danish adults. Respondents received online questionnaires of GJHk and KJH, knee joint symptoms, the severity and duration of these, as well as HRQoL. RESULTS: Total response rate was 49% (n = 1006). The prevalence of self...

  20. Reliability Analysis of Tubular Joints in Offshore Structures

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle; Sørensen, John Dalsgaard

    1987-01-01

    Reliability analysis of single tubular joints and offshore platforms with tubular joints is" presented. The failure modes considered are yielding, punching, buckling and fatigue failure. Element reliability as well as systems reliability approaches are used and illustrated by several examples....... Finally, optimal design of tubular.joints with reliability constraints is discussed and illustrated by an example....

  1. MP Joint Arthritis

    Science.gov (United States)

    ... crack extends into the joint Certain medical conditions ( rheumatoid arthritis , gout and pseudogout , psoriasis, etc.) Infections, often after a cut, puncture or animal bites where bacteria are introduced into the joint and cause rapid ...

  2. Knee joint replacement - slideshow

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/presentations/100088.htm Knee joint replacement - series—Normal anatomy To use the ... to slide 4 out of 4 Overview The knee is a complex joint. It contains the distal ...

  3. Distal radioulnar joint injuries

    OpenAIRE

    Thomas, Binu P.; Raveendran Sreekanth

    2012-01-01

    Distal radioulnar joint is a trochoid joint relatively new in evolution. Along with proximal radioulnar joint , forearm bones and interosseous membrane, it allows pronosupination and load transmission across the wrist. Injuries around distal radioulnar joint are not uncommon, and are usually associated with distal radius fractures,fractures of the ulnar styloid and with the eponymous Galeazzi or Essex_Lopresti fractures. The injury can be purely involving the soft tissue especially the triang...

  4. Progress of JT-60SA Project: EU-JA joint efforts for assembly and fabrication of superconducting tokamak facilities and its research planning

    Energy Technology Data Exchange (ETDEWEB)

    Shirai, Hiroshi, E-mail: shirai.hiroshi@jaea.go.jp [JT-60SA Project Team, Japan Atomic Energy Agency, 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan); Barabaschi, Pietro [JT-60SA EU-Home Team, Fusion for Energy, Boltsmannstr 2, Garching 85748 (Germany); Kamada, Yutaka [JT-60SA JA-Home Team, Japan Atomic Energy Agency, 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan)

    2016-11-01

    Highlights: • JT-60SA Project is promoted under the BA Agreement and JA national programme. • JT-60SA is designed to operate in break-even equivalent condition for a long period. • JT-60SA Project supports and complements the ITER project, and promotes DEMO design. • Fabrication of JT-60SA components and assembly in Naka are steadily going on. • JT-60SA Research Plan has been developed jointly by EU and JA fusion communities. - Abstract: Aiming at supporting the early realization of fusion energy, the JT-60SA Project has shown steady progress for several years toward the first plasma in 2019 under the dual frameworks: the Satellite Tokamak Programme of the Broader Approach Agreement between EU and Japan, and the Japanese national programme. JT-60SA is a superconducting tokamak designed to operate in break-even equivalent conditions for a long pulse duration (typically 100 s) with a maximum plasma current of 5.5 MA. A variety of plasma control capabilities enable JT-60SA to contribute directly to the ITER project and also to DEMO by addressing key engineering and physics issues for advanced plasma operation. Design and fabrication of JT-60SA components, shared by the EU and Japan, started in 2007. Assembly in the torus hall started in January 2013, and welding work of the vacuum vessel sectors (seven 40° sectors and two 30° sectors) is currently ongoing on the cryostat base. Other components such as TF coils, PF coils, power supplies, cryogenic system, cryostat vessel, thermal shields and so on were or are being delivered to the Naka site for installation, assembly and commissioning. This paper gives technical progress on fabrication, installation and assembly of tokamak components and ancillary systems, as well as progress of the JT-60SA Research Plan being developed jointly by European and Japanese fusion communities.

  5. International joint ventures

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    2001-01-01

    The article analysis problems connected with corporate joint ventures. Among others the possible conflicts between the joint venture agreement and the statutes of the companies is examined, as well as certain problems connected to the fact that the joint venture partners have created commen contr...

  6. From design to implementation - The Joint Asia Diabetes Evaluation (JADE program: A descriptive report of an electronic web-based diabetes management program

    Directory of Open Access Journals (Sweden)

    Lyubomirsky Greg

    2010-05-01

    Full Text Available Abstract Background The Joint Asia Diabetes Evaluation (JADE Program is a web-based program incorporating a comprehensive risk engine, care protocols, and clinical decision support to improve ambulatory diabetes care. Methods The JADE Program uses information technology to facilitate healthcare professionals to create a diabetes registry and to deliver an evidence-based care and education protocol tailored to patients' risk profiles. With written informed consent from participating patients and care providers, all data are anonymized and stored in a databank to establish an Asian Diabetes Database for research and publication purpose. Results The JADE electronic portal (e-portal: http://www.jade-adf.org is implemented as a Java application using the Apache web server, the mySQL database and the Cocoon framework. The JADE e-portal comprises a risk engine which predicts 5-year probability of major clinical events based on parameters collected during an annual comprehensive assessment. Based on this risk stratification, the JADE e-portal recommends a care protocol tailored to these risk levels with decision support triggered by various risk factors. Apart from establishing a registry for quality assurance and data tracking, the JADE e-portal also displays trends of risk factor control at each visit to promote doctor-patient dialogues and to empower both parties to make informed decisions. Conclusions The JADE Program is a prototype using information technology to facilitate implementation of a comprehensive care model, as recommended by the International Diabetes Federation. It also enables health care teams to record, manage, track and analyze the clinical course and outcomes of people with diabetes.

  7. From design to implementation--the Joint Asia Diabetes Evaluation (JADE) program: a descriptive report of an electronic web-based diabetes management program.

    Science.gov (United States)

    Ko, Gary T; So, Wing-Yee; Tong, Peter C; Le Coguiec, Francois; Kerr, Debborah; Lyubomirsky, Greg; Tamesis, Beaver; Wolthers, Troels; Nan, Jennifer; Chan, Juliana

    2010-05-13

    The Joint Asia Diabetes Evaluation (JADE) Program is a web-based program incorporating a comprehensive risk engine, care protocols, and clinical decision support to improve ambulatory diabetes care. The JADE Program uses information technology to facilitate healthcare professionals to create a diabetes registry and to deliver an evidence-based care and education protocol tailored to patients' risk profiles. With written informed consent from participating patients and care providers, all data are anonymized and stored in a databank to establish an Asian Diabetes Database for research and publication purpose. The JADE electronic portal (e-portal: http://www.jade-adf.org) is implemented as a Java application using the Apache web server, the mySQL database and the Cocoon framework. The JADE e-portal comprises a risk engine which predicts 5-year probability of major clinical events based on parameters collected during an annual comprehensive assessment. Based on this risk stratification, the JADE e-portal recommends a care protocol tailored to these risk levels with decision support triggered by various risk factors. Apart from establishing a registry for quality assurance and data tracking, the JADE e-portal also displays trends of risk factor control at each visit to promote doctor-patient dialogues and to empower both parties to make informed decisions. The JADE Program is a prototype using information technology to facilitate implementation of a comprehensive care model, as recommended by the International Diabetes Federation. It also enables health care teams to record, manage, track and analyze the clinical course and outcomes of people with diabetes.

  8. Progressive Damage Analysis of Bonded Composite Joints

    Science.gov (United States)

    Leone, Frank A., Jr.; Girolamo, Donato; Davila, Carlos G.

    2012-01-01

    The present work is related to the development and application of progressive damage modeling techniques to bonded joint technology. The joint designs studied in this work include a conventional composite splice joint and a NASA-patented durable redundant joint. Both designs involve honeycomb sandwich structures with carbon/epoxy facesheets joined using adhesively bonded doublers.Progressive damage modeling allows for the prediction of the initiation and evolution of damage within a structure. For structures that include multiple material systems, such as the joint designs under consideration, the number of potential failure mechanisms that must be accounted for drastically increases the complexity of the analyses. Potential failure mechanisms include fiber fracture, intraply matrix cracking, delamination, core crushing, adhesive failure, and their interactions. The bonded joints were modeled using highly parametric, explicitly solved finite element models, with damage modeling implemented via custom user-written subroutines. Each ply was discretely meshed using three-dimensional solid elements. Layers of cohesive elements were included between each ply to account for the possibility of delaminations and were used to model the adhesive layers forming the joint. Good correlation with experimental results was achieved both in terms of load-displacement history and the predicted failure mechanism(s).

  9. Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism.

    Science.gov (United States)

    Silverman, J L; Yang, M; Turner, S M; Katz, A M; Bell, D B; Koenig, J I; Crawley, J N

    2010-12-29

    Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR T+tf/J (BTBR) is an inbred mouse strain that displays robust behavioral phenotypes with analogies to all three of the diagnostic symptoms of autism, including low social interactions, reduced vocalizations in social settings, and high levels of repetitive self-grooming. Autism-relevant phenotypes in BTBR offer translational tools to discover neurochemical mechanisms underlying unusual mouse behaviors relevant to symptoms of autism. Because repetitive self-grooming in mice may be a displacement behavior elevated by stressors, we investigated neuroendocrine markers of stress and behavioral reactivity to stressors in BTBR mice, as compared to C57BL/6J (B6), a standard inbred strain with high sociability. Radioimmunoassays replicated previous findings that circulating corticosterone is higher in BTBR than in B6. Higher basal glucocorticoid receptor mRNA and higher oxytocin peptide levels were detected in the brains of BTBR as compared to B6. No significant differences were detected in corticotrophin releasing factor (CRF) peptide or CRF mRNA. In response to behavioral stressors, BTBR and B6 were generally similar on behavioral tasks including stress-induced hyperthermia, elevated plus-maze, light ↔ dark exploration, tail flick, acoustic startle and prepulse inhibition. BTBR displayed less reactivity than B6 to a noxious thermal stimulus in the hot plate, and less immobility than B6 in both the forced swim and tail suspension depression-related tasks. BTBR, therefore, exhibited lower depression-like scores than B6 on two standard tests sensitive to antidepressants, did not differ from B6 on two well-validated anxiety-like behaviors, and did not exhibit unusual stress reactivity to sensory stimuli. Our findings support the interpretation that autism-relevant social deficits, vocalizations, and

  10. Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders.

    Science.gov (United States)

    Burket, Jessica A; Benson, Andrew D; Tang, Amy H; Deutsch, Stephen I

    2014-01-01

    Overactivation of the mammalian target of rapamycin (mTOR) has been implicated in the pathogenesis of syndromic forms of autism spectrum disorders (ASDs), such as tuberous sclerosis complex, neurofibromatosis 1, and fragile X syndrome. Administration of mTORC1 (mTOR complex 1) inhibitors (e.g. rapamycin) in syndromic mouse models of ASDs improved behavior, cognition, and neuropathology. However, since only a minority of ASDs are due to the effects of single genes (∼10%), there is a need to explore inhibition of mTOR activity in mouse models that may be more relevant to the majority of nonsyndromic presentations, such as the genetically inbred BTBR T(+)Itpr3(tf)/J (BTBR) mouse model of ASDs. BTBR mice have social impairment and exhibit increased stereotypic behavior. In prior work, d-cycloserine, a partial glycineB site agonist that targets the N-methyl-d-aspartate (NMDA) receptor, was shown to improve sociability in both Balb/c and BTBR mouse models of ASDs. Importantly, NMDA receptor activation regulates mTOR signaling activity. The current study investigated the ability of rapamycin (10mg/kg, i.p.×four days), an mTORC1 inhibitor, to improve sociability and stereotypic behavior in BTBR mice. Using a standard paradigm to assess mouse social behavior, rapamycin improved several measures of sociability in the BTBR mouse, suggesting that mTOR overactivation represents a therapeutic target that mediates or contributes to impaired sociability in the BTBR mouse model of ASDs. Interestingly, there was no effect of rapamycin on stereotypic behaviors in this mouse model. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. The effect of different design concepts in lumbar total disc arthroplasty on the range of motion, facet joint forces and instantaneous center of rotation of a L4-5 segment.

    Science.gov (United States)

    Schmidt, Hendrik; Midderhoff, Stefan; Adkins, Kyle; Wilke, Hans-Joachim

    2009-11-01

    Although both unconstrained and constrained core lumbar artificial disc designs are in clinical use, the effect of their design on the range of motion, center of rotations, and facet joint forces is not well understood. It is assumed that the constrained configuration causes a fixed center of rotation with high facet forces, while the unconstrained configuration leads to a moving center of rotation with lower loaded facets. The authors disagree with both assumptions and hypothesized that the two different designs do not lead to substantial differences in the results. For the different implant designs, a three-dimensional finite element model was created and subsequently inserted into a validated model of a L4-5 lumbar spinal segment. The unconstrained design was represented by two implants, the Charité disc and a newly developed disc prosthesis: Slide-Disc. The constrained design was obtained by a modification of the Slide-Disc whereby the inner core was rigidly connected to the lower metallic endplate. The models were exposed to an axial compression preload of 1,000 N. Pure unconstrained moments of 7.5 Nm were subsequently applied to the three anatomical main planes. Except for extension, the models predicted only small and moderate inter-implant differences. The calculated values were close to those of the intact segment. For extension, a large difference of about 45% was calculated between both Slide-Disc designs and the Charité disc. The models predicted higher facet forces for the implants with an unconstrained core compared to an implant with a constrained core. All implants caused a moving center of rotation. Except for axial rotation, the unconstrained and constrained configurations mimicked the intact situation. In axial rotation, only the Slide- Disc with mobile core reproduced the intact behavior. Results partially support our hypothesis and imply that different implant designs do not lead to strong differences in the range of motion and the location

  12. Hydrocolonotherapy ankle joints after injuries

    Directory of Open Access Journals (Sweden)

    Volodymyr Muchin

    2016-02-01

    Full Text Available Purpose: to improve efficiency of gydrokinesitherapy by means of specially designed devices and monolasts for patients after ankle joint injuries. Material & Methods: there are pedagogical methods, clinical and radiological methods, anthropometric measurements and goniometry were used. Results: the author's technique of hydrokinesitherapy with application hydrokinesimechanotherapy device in the program of physical rehabilitation which provides optimum conditions for the recovery process was developed. Conclusions: the specially designed hydrokinesomechanotherapeutic device and monolasts are allow strictly controlled movement in all planes of the ankle joint, which contributes to the acceleration of the recovery; the conducted anthropometric and goniometric studies were indicate more rapid elimination of edema, increase movement amplitude, carries opposition to the development of contractures and muscle atrophy.

  13. Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Pettiway, Keon

    2017-01-01

    by designers, planners, etc. (staging from above) and mobile subjects (staging from below). A research agenda for studying situated practices of mobility and mobilities design is outlined in three directions: foci of studies, methods and approaches, and epistemologies and frames of thinking. Jensen begins......In this chapter, Ole B. Jensen takes a situational approach to mobilities to examine how ordinary life activities are structured by technology and design. Using “staging mobilities” as a theoretical approach, Jensen considers mobilities as overlapping, actions, interactions and decisions...... with a brief description of how movement is studied within social sciences after the “mobilities turn” versus the idea of physical movement in transport geography and engineering. He then explains how “mobilities design” was derived from connections between traffic and architecture. Jensen concludes...

  14. The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo.

    Science.gov (United States)

    Inamdar, Shashikala R; Savanur, Mohammed Azharuddin; Eligar, Sachin M; Chachadi, Vishwanath B; Nagre, Nagaraja N; Chen, Chen; Barclays, Monica; Ingle, Aravind; Mahajan, Praveen; Borges, Anita; Shastry, Padma; Kalraiya, Rajiv D; Swamy, Bale M; Rhodes, Jonathan M; Yu, Lu-Gang

    2012-09-01

    Glycan array analysis of Sclerotium rolfsii lectin (SRL) revealed its exquisite binding specificity to the oncofetal Thomsen-Friedenreich (Galβ1-3GalNAcα-O-Ser/Thr, T or TF) antigen and its derivatives. This study shows that SRL strongly inhibits the growth of human colon cancer HT29 and DLD-1 cells by binding to cell surface glycans and induction of apoptosis through both the caspase-8 and -9 mediated signaling. SRL showed no or very weak binding to normal human colon tissues but strong binding to cancerous and metastatic tissues. Intratumor injection of SRL at subtoxic concentrations in NOD-SCID mice bearing HT29 xenografts resulted in total tumor regression in 9 days and no subsequent tumor recurrence. As the increased expression of TF-associated glycans is commonly seen in human cancers, SRL has the potential to be developed as a therapeutic agent for cancer.

  15. Identification of novel mutations in HFE, HFE2, TfR2, and SLC40A1 genes in Chinese patients affected by hereditary hemochromatosis.

    Science.gov (United States)

    Wang, Yongwei; Du, Yali; Liu, Gang; Guo, Shanshan; Hou, Bo; Jiang, Xianyong; Han, Bing; Chang, Yanzhong; Nie, Guangjun

    2017-04-01

    Hereditary hemochromatosis (HH) is a group of inherited iron-overload disorders associated with pathogenic defects in the genes encoding hemochromatosis (HFE), hemojuvelin (HJV/HFE2), hepcidin (HAMP), transferrin receptor 2 (TfR2), and ferroportin (FPN1/SLC40A1) proteins, and the clinical features are well described. However, there have been only a few detailed reports of HH in Chinese populations. Thus, there is insufficient patient information for population-based analyses in Chinese populations or comparative studies among different ethical groups. In the current work, we describe eight Chinese cases of hereditary hemochromatosis. Gene sequencing results revealed eight mutations (five novel mutations) in HFE, HFE2, TfR2, and SLC40A1 genes in these Chinese HH patients. In addition, we used Polymorphism Phenotyping v2 (Polyphen), Sorting Intolerant From Tolerant (SIFT), and a sequence alignment program to predict the molecular consequences of missense mutations.

  16. Design

    DEFF Research Database (Denmark)

    Volf, Mette

    Design - proces & metode iBog®  er enestående i sit fokus på afmystificering og operationalisering af designprocessens flygtige og komplekse karakter. Udgivelsen går bag om designerens daglige arbejde og giver et indblik i den kreative skabelsesproces, som designeren er en del af. Udover et bredt...... indblik i designerens arbejdsmetoder og designparametre giver Design - proces & metode en række eksempler fra anerkendte designvirksomheder, der gør det muligt at komme helt tæt på designerens virkelighed....

  17. DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a-N1'-linked pyrroloindoline alkaloids.

    Science.gov (United States)

    Tayu, Masanori; Ishizaki, Takako; Higuchi, Kazuhiro; Kawasaki, Tomomi

    2015-04-07

    The cross-coupling of tryptamine with substituted aniline to access C3a-nitrogen-linked pyrroloindolines has been developed via the consecutive cyclization of tryptamine with DMSO/Tf2O and the substitution of 3a-pyrroloindolylthionium intermediate with aniline. The use of 2,3-dihydrotryptamine instead of aniline enabled easy access to 3a-(1-indolyl)pyrroloindoline and the concise synthesis of C3a-N1'-linked pyrroloindoline alkaloid (±)-psychotriasine was accomplished.

  18. Modes of Large-Scale Brain Network Organization during Threat Processing and Posttraumatic Stress Disorder Symptom Reduction during TF-CBT among Adolescent Girls.

    Directory of Open Access Journals (Sweden)

    Josh M Cisler

    Full Text Available Posttraumatic stress disorder (PTSD is often chronic and disabling across the lifespan. The gold standard treatment for adolescent PTSD is Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT, though treatment response is variable and mediating neural mechanisms are not well understood. Here, we test whether PTSD symptom reduction during TF-CBT is associated with individual differences in large-scale brain network organization during emotion processing. Twenty adolescent girls, aged 11-16, with PTSD related to assaultive violence completed a 12-session protocol of TF-CBT. Participants completed an emotion processing task, in which neutral and fearful facial expressions were presented either overtly or covertly during 3T fMRI, before and after treatment. Analyses focused on characterizing network properties of modularity, assortativity, and global efficiency within an 824 region-of-interest brain parcellation separately during each of the task blocks using weighted functional connectivity matrices. We similarly analyzed an existing dataset of healthy adolescent girls undergoing an identical emotion processing task to characterize normative network organization. Pre-treatment individual differences in modularity, assortativity, and global efficiency during covert fear vs neutral blocks predicted PTSD symptom reduction. Patients who responded better to treatment had greater network modularity and assortativity but lesser efficiency, a pattern that closely resembled the control participants. At a group level, greater symptom reduction was associated with greater pre-to-post-treatment increases in network assortativity and modularity, but this was more pronounced among participants with less symptom improvement. The results support the hypothesis that modularized and resilient brain organization during emotion processing operate as mechanisms enabling symptom reduction during TF-CBT.

  19. Modes of Large-Scale Brain Network Organization during Threat Processing and Posttraumatic Stress Disorder Symptom Reduction during TF-CBT among Adolescent Girls.

    Science.gov (United States)

    Cisler, Josh M; Sigel, Benjamin A; Kramer, Teresa L; Smitherman, Sonet; Vanderzee, Karin; Pemberton, Joy; Kilts, Clinton D

    2016-01-01

    Posttraumatic stress disorder (PTSD) is often chronic and disabling across the lifespan. The gold standard treatment for adolescent PTSD is Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT), though treatment response is variable and mediating neural mechanisms are not well understood. Here, we test whether PTSD symptom reduction during TF-CBT is associated with individual differences in large-scale brain network organization during emotion processing. Twenty adolescent girls, aged 11-16, with PTSD related to assaultive violence completed a 12-session protocol of TF-CBT. Participants completed an emotion processing task, in which neutral and fearful facial expressions were presented either overtly or covertly during 3T fMRI, before and after treatment. Analyses focused on characterizing network properties of modularity, assortativity, and global efficiency within an 824 region-of-interest brain parcellation separately during each of the task blocks using weighted functional connectivity matrices. We similarly analyzed an existing dataset of healthy adolescent girls undergoing an identical emotion processing task to characterize normative network organization. Pre-treatment individual differences in modularity, assortativity, and global efficiency during covert fear vs neutral blocks predicted PTSD symptom reduction. Patients who responded better to treatment had greater network modularity and assortativity but lesser efficiency, a pattern that closely resembled the control participants. At a group level, greater symptom reduction was associated with greater pre-to-post-treatment increases in network assortativity and modularity, but this was more pronounced among participants with less symptom improvement. The results support the hypothesis that modularized and resilient brain organization during emotion processing operate as mechanisms enabling symptom reduction during TF-CBT.

  20. Design

    Science.gov (United States)

    Buchanan, Richard; Cross, Nigel; Durling, David; Nelson, Harold; Owen, Charles; Valtonen, Anna; Boling, Elizabeth; Gibbons, Andrew; Visscher-Voerman, Irene

    2013-01-01

    Scholars representing the field of design were asked to identify what they considered to be the most exciting and imaginative work currently being done in their field, as well as how that work might change our understanding. The scholars included Richard Buchanan, Nigel Cross, David Durling, Harold Nelson, Charles Owen, and Anna Valtonen. Scholars…

  1. Development Requirements for Spacesuit Elbow Joint

    Science.gov (United States)

    Peters, Benjamin

    2017-01-01

    Functional Requirements for spacesuit elbow joint:1) The system is a conformal, single-axis spacesuit pressurized joint that encloses the elbow joint of the suited user and uses a defined interface to connect to the suit systems on either side of the joint.2) The system shall be designed to bear the loads incurred from the internal pressure of the system, as well as the expected loads induced by the user while enabling the user move the joint through the required range of motion. The joint torque of the system experienced by the user shall remain at or below the required specification for the entire range of motion.3) The design shall be constructed, at a minimum, as a two-layer system. The internal, air-tight layer shall be referred to as the bladder, and the layer on the unpressurized side of the bladder shall be referred to as the restraint. The design of the system may include additional features or layers, such as axial webbing, to meet the overall requirements of the design.

  2. Plasma free tissue factor pathway inhibitor (TFPI) levels and TF-induced thrombin generation ex vivo in men with low testosterone levels.

    Science.gov (United States)

    Agledahl, Ingvild; Brodin, Ellen; Svartberg, Johan; Hansen, John-Bjarne

    2009-03-01

    Low testosterone levels in men have been associated with cardiovascular risk factors, some prothrombotic factors, and lately also an increased risk of both cardiovascular disease and all-cause mortality. Experimental studies have shown increased synthesis and release of tissue factor pathway inhibitor (TFPI) by physiological levels of testosterone in endothelial cells. Our hypothesis was that elderly men with low testosterone levels would have lower plasma levels of plasma free TFPI with subsequent increased thrombin generation. Elderly men with low (n = 37) and normal (n = 41) testosterone levels were recruited from a general population, and tissue factor (TF)-induced thrombin generation ex vivo and plasma free TFPI Ag were measured. Elderly men with low testosterone levels had lower plasma free TFPI Ag (10.9 +/- 2.3 ng/ml vs. 12.3 +/- 3.0 ng/ml, p = 0.027) and shorter initiation phase of TF-induced coagulation assessed by lag-time (5.1 +/- 1.0 min vs. 5.7 +/- 1.3, p = 0.039). The differences between groups remained significant and were strengthened after adjustment for waist circumference and other cardiovascular risk factors. Lag-time increased linearly across quartiles of plasma free TFPI Ag (ptestosterone were independent predictors of plasma free TFPI Ag. Our findings suggest that low testosterone levels in elderly men is associated with low plasma free TFPI Ag and subsequent shortened initiation phase of TF-induced coagulation.

  3. TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.

    Science.gov (United States)

    An, Peng; Wu, Qian; Wang, Hao; Guan, Yu; Mu, Mingdao; Liao, Yijun; Zhou, Daizhan; Song, Pengkun; Wang, Chunrong; Meng, Liping; Man, Qingqing; Li, Lixiang; Zhang, Jian; Wang, Fudi

    2012-05-01

    A variety of conditions lead to anemia, which affects one-quarter of the world's population. Previous genome-wide association studies revealed a number of genetic polymorphisms significantly associated with plasma iron status. To evaluate the association of genetic variants in genes involved in iron delivery and hepcidin regulation pathways with the risk of iron-deficiency anemia (IDA), the following single nucleotide polymorphisms were genotyped in 2139 unrelated elderly Chinese women: rs3811647 (TF), rs7385804 (TFR2), rs235756 (BMP2), and rs855791(V736A) and rs4820268 (TMPRSS6, encoding matriptase-2). We identified common variants in TMPRSS6 as being genetic risk factors for both iron deficiency (OR(rs855791) = 1.55, P = 4.96 × 10(-8)) and IDA (OR(rs855791) = 1.78, P = 8.43 × 10(-9)). TMPRSS6 polymorphisms were also associated with lower serum iron (SI) and hemoglobin levels, consistent with their associations to increased iron deficiency and anemia risk. Variants rs3811647 in TF and rs7385804 in TFR2 were associated with reduced SI, serum transferrin and transferrin saturation levels; however, these variants were not associated with iron deficiency or anemia risk. Our findings suggest that TF, TFR2 and TMPRSS6 polymorphisms are significantly associated with decreased iron status, but only variants in TMPRSS6 are genetic risk factors for iron deficiency and IDA.

  4. Genetic study of African populations: polymorphisms of the plasma proteins TF, PL, F13B, and AHSG in populations of Namibia and Mozambique.

    Science.gov (United States)

    Bieber, H; Bieber, S W; Rodewald, A; Christiansen, K

    1997-02-01

    Genetic variations of four highly polymorphic serum proteins, TF, PI, F13B, and AHSG, were tested to distinguish one black African and one Khoisan population of southwest Africa. The results show that indeed the systems TF, PI, and AHSG are of high value for anthropological genetics: The allele frequencies for these systems enable clear identification of and distinction between black African and Khoisan populations. The F13B locus, on the other hand, reveals for both the black African and the Khoisan populations specific and unique African variants: a high frequency of F13B*2 and the lowest frequency of F13B*3 so far worldwide. The new data are compared with results for TF and PI in another black African population of Mozambique, which Rodewald et al. (1988) had studied previously. The dendrogram, based on genetic distance data D and average linkage cluster analysis, shows minimal distance between both black African populations of Namibia and Mozambique and marked distance between those and the Khoisan population of Namibia.

  5. Microparticles (MPs), tissue factor (TF) and tissue factor inhibitor (TFPI) in cord blood plasma. A preliminary study and literature survey of procoagulant properties of MPs.

    Science.gov (United States)

    Uszyński, Mieczysław; Zekanowska, Ewa; Uszyński, Waldemar; Kuczyński, Jarosław; Zyliński, Andrzej

    2011-09-01

    In the working hypothesis we assumed that the procoagulant activity of microparticles (MPs) is associated with the concentration of tissue factor (TF) and its inhibitor (TFPI), and that these three components together affect fetal hemostasis. The aim of the study was to check whether MPs are present in the cord blood, to compare their concentration with that in the maternal blood, as well as to measure the concentrations of TF antigen and TFPI antigen in the cord blood and maternal blood. The study group consisted of 28 healthy parturient women who gave normal delivery, and their 28 babies. Blood from the umbilical vein was collected immediately after delivery, still prior to omphalotomy, whereas mother's blood was obtained from the antecubital vein. The concentration of MPs as well as TF antigen and TFPI antigen were measured using ELISA method. The level of MPs in cord blood plasma was found to be 6.25 times higher than in the mother's blood plasma (median: 26.76 nM PS; range: 22.90-34.41 nM PS vs. median: 4.26 nM PS; range: 2.68-5.37 nM PS respectively, p=0.0022), whereas the level of TF antigen was 1.94 times higher in the fetus than in the mother (median: 238.03 pg/ml; range: 192.25-283.10 pg/ml vs. median: 122.4 pg/ml, range: 52.71-176.74 pg/ml, respectively, p=0.0012). On the other hand, the level of TFPI antigen was lower in cord blood plasma than in maternal blood plasma, accounting for 33.95% of the value noted in the mother (median: 30.04 ng/ml, range: 24.84-35.12 ng/ml vs. median: 88.48 ng/ml; range: 78.64-107.20 ng/ml, respectively, pcord blood plasma; their concentration is significantly higher than that in mother's blood plasma. In the fetus, MPs may play a role of a powerful procoagulant, thus facilitating thrombin generation (TF-dependent thrombin generation, which may take place on their surface); this hypothesis is based on literature data and our own evidence. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  6. Elbow joint instability

    DEFF Research Database (Denmark)

    Olsen, Bo Sanderhoff; Henriksen, M G; Søjbjerg, Jens Ole

    1994-01-01

    The effect of simultaneous ulnar and radial collateral ligament division on the kinematics of the elbow joint is studied in a cadaveric model. Severance of the anterior part of the ulnar collateral ligament and the annular ligament led to significant elbow joint instability in valgus and varus...... of the specimens was recorded. The reproducibility of the instability pattern suggests that this model is suitable for evaluating stabilizing procedures aimed at correction of elbow joint instability before these procedures are introduced into patient care....

  7. Jointly Poisson processes

    OpenAIRE

    Johnson, D. H.; Goodman, I. N.

    2009-01-01

    What constitutes jointly Poisson processes remains an unresolved issue. This report reviews the current state of the theory and indicates how the accepted but unproven model equals that resulting from the small time-interval limit of jointly Bernoulli processes. One intriguing consequence of these models is that jointly Poisson processes can only be positively correlated as measured by the correlation coefficient defined by cumulants of the probability generating functional.

  8. Debonding problem of a transversely loaded single lap joint

    Energy Technology Data Exchange (ETDEWEB)

    Tang, J.H.; Sridhar, I.; Tan, G.E.B. [Nanyang Technological Univ., Singapore (Singapore)

    2012-07-01

    This paper aims to describe the debonding problem of transversely loaded single lap joint using fracture mechanics approach. This is achieved by first solving the deflection problem of the single lap joint. By evaluating the bending moments at the vicinity of crack tip, non-dimensional energy release rate required for the debonding can be found. The effects of relative position of transverse load and overlap length on the debonding propensity are discussed. As for design consideration, any transverse load moving towards critical side of square edge of the joint should be avoided. Increasing the overlap length improves the joint's strength, particularly when the joint is also axially loaded. (Author)

  9. Affecting aspects on the behaviour of frame joints

    Directory of Open Access Journals (Sweden)

    Mohamed Nabil

    2016-08-01

    The presented paper introduces an experimental and analytical study in order to investigate the effect of reinforcement details, confinement, joints size, joints angle on the frame joints efficiency and comparison between closing joints and opening joints. Experimentally, a total of eleven specimens were tested under vertical load. All specimens were tested up to failure and the behaviour was fully monitored. Moreover, a nonlinear 3D-finite element analysis was established using ABAQUS program and verified with the experimental results in order to give design recommendations for those structural elements.

  10. Fatigue classification of welded joints in orthotropic steel bridge decks

    NARCIS (Netherlands)

    Kolstein, M.H.

    2007-01-01

    This dissertation presents the research into fatigue classifications of welded joints in orthotropic steel bridge decks. These classifications are needed to calculate the fatigue life of these joints and should be included in the design codes. For years bridge design was mainly based on static

  11. Preliminary conceptual design for geothermal space heating conversion of school district 50 joint facilities at Pagosa Springs, Colorado. GTA report no. 6

    Science.gov (United States)

    Engen, I. A.

    1981-11-01

    This feasibility study and preliminary conceptual design effect assesses the conversion of a high school and gym, and a middle school building to geothermal space heating is assessed. A preliminary cost benefit assessment made on the basis of estimated costs for conversion, system maintenance, debt service, resource development, electricity to power pumps, and savings from from reduced natural gas consumption concluded that an economic conversion depended on development of an adequate geothermal resource (approximately 1500F, 400 gpm). Material selection assumed that the geothermal water to the main supply system was isolated to minimize effects of corrosion and deposition, and that system compatible components are used for the building modifications. Asbestos cement distribution pipe, a stainless steel heat exchanger, and stainless steel lined valves were recommended for the supply, heat transfer, and disposal mechanisms, respectively. A comparison of the calculated average gas consumption cost, escalated at 10% per year, with conversion project cost, both in 1977 dollars, showed that the project could be amortized over less than 20 years at current interest rates.

  12. APPLICATION PROSPECTS OF THREADED JOINT OF ARMATURE

    Directory of Open Access Journals (Sweden)

    A. V. Radkevych

    2014-06-01

    Full Text Available Purpose. One of the main technological operations of buildings construction on the basis of monolithic frame systems is the production of mesh reinforcement. The current interest is the new ways specification of advanced bonding armature techniques without reliability weakness and design of the building in whole, as well as the finding of use prospects of screw-threaded joint of armature as the most technological and economic method of re-bars joints. Methodology. Advantages and disadvantages analysis of existing rebar compound technologies was implemented by couplings of different types and constructions. The most promising vertical constructions for the vertical bars joints in frameworks were determined. Findings. Researches of existing technologies of rebar joints by the couplings of different construction were carried out. The installation method of mesh reinforcement of vertical structural elements with the use of the special catching devices was developed. It allows considerably accelerating installation of mesh reinforcement. Originality. Regularity of labor intensiveness change of mesh reinforcement installation of columns at armature joint in vertical position by threaded couplings with the help of catching devices using special construction was determined. This allows substantially reducing the labor expenditures during installation of these elements. Dependency of labor intensiveness and cost of lap welding armature joints, by tub-seam welding and by thread coupling depending on its diameter was designated. Regularity of labor intensiveness changes of installation at armature joints by different methods taking into account preparatory works was defined. Practical value. The analysis of mechanical armature joints techniques was conducted. It will allow selecting methods of armature joints to increase the speed of construction works more economical and effective.

  13. Corrosion damage of rivet joints

    Directory of Open Access Journals (Sweden)

    Michal Černý

    2008-01-01

    Full Text Available The work describes the effect of the atmospheric corrosion upon the mechanical properties of blind rivets. The subject of given research is: corrosion of metal materials, system resistance, design modification and others means of prevention against the corrosion attack. The problem of blind rivets, blind rivet setting, setting equipment, terminology and definitions, characteristic, and special blind rivet setting is also analysed. The experiment itself, the experimental method and the evaluation of the test are described. Mechanism of riveted joint damage produced by galvanic corrosion is proposed. Considerable corrosion damage occurred at combination of the joint members and connected materials with different electrochemical potentials. Exposition to the corroding environment produces release of rivet clam, together with decrease of rivet stiffness. The proof of these mechanisms is documented by functional dependence F – ∆L and metallographic tests.

  14. MR diagnosis of temporomandibular joint. A study of joint effusion

    Energy Technology Data Exchange (ETDEWEB)

    Kaneda, Takashi; Yamashiro, Mitsuaki; Ozawa, Kaoru; Suzuki, Hiromi; Okada, Hiroyuki; Yamamoto, Hirotsugu [Nihon Univ., Matsudo, Chiba (Japan). School of Dentistry

    1998-03-01

    The purposes of this study were to evaluate the relationship between correlation of MR joint effusion of the temporomandibular joint and disk position, to evaluate the relationship between joint effusion and aging, and to assess the frequency of MR joint effusion of bilateral temporomandibular joints. The temporomandibular joints of 192 patients with clinical symptoms of temporomandibular joint disorders were imaged bilaterally using high field, surface-coil MR imaging. Oblique sagittal and coronal proton density-weighted and T2-weighted images were obtained. Imaging findings of joint effusion were correlated with disk position, aging, and bilateral temporomandibular joints. MR showed effusion in 4% of the joints with normal superior disk position, 36% of the joints with disk displacement with reduction, and 45% of the joints with disk displacement without reduction. There were significant differences in the incidence of joint effusion between normal disk position and anterior disk displacement with or without reduction. Younger patients less than 40 years were significant higher the incidence of joint effusion than those of older patients. A significant association was seen between joint effusion and aging. MR showed effusion in 17% of the unilateral temporomandibular joint, 24% of the bilateral temporomandibular joints. There was no significant difference between unilateral and bilateral case. These results indicated that joint effusion using MR imaging was associated with varied temporomandibular joint pathologic states. (author)

  15. Creep of timber joints

    NARCIS (Netherlands)

    Van de Kuilen, J.W.G.

    2008-01-01

    A creep analysis has been performed on nailed, toothed-plates and split-ring joints in a varying uncontrolled climate. The load levels varied between 30% and 50% of the average ultimate short term strength of these joints, tested in accordance with ISO 6891. The climate in which the tests were

  16. 13. Sacroiliac joint pain

    NARCIS (Netherlands)

    Vanelderen, P.; Szadek, K.M.; Cohen, S.P.; Witte, J.; Lataster, A.; Patijn, J.; Mekhail, N.; van Kleef, M.; van Zundert, J.

    2010-01-01

    The sacroiliac joint accounts for approximately 16% to 30% of cases of chronic mechanical low back pain. Pain originating in the sacroiliac joint is predominantly perceived in the gluteal region, although pain is often referred into the lower and upper lumbar region, groin, abdomen, and/ or lower

  17. Flat H Frangible Joint Evolution

    Science.gov (United States)

    Diegelman, Thomas E.; Hinkel, Todd J.; Benjamin, Andrew; Rochon, Brian V.; Brown, Christopher W.

    2016-01-01

    Space vehicle staging and separation events require pyrotechnic devices. They are single-use mechanisms that cannot be tested, nor can failure-tolerant performance be demonstrated in actual flight articles prior to flight use. This necessitates the implementation of a robust design and test approach coupled with a fully redundant, failure-tolerant explosive mechanism to ensure that the system functions even in the event of a single failure. Historically, NASA has followed the single failure-tolerant (SFT) design philosophy for all human-rated spacecraft, including the Space Shuttle Program. Following the end of this program, aerospace companies proposed building the next generation human-rated vehicles with off-the-shelf, non-redundant, zero-failure-tolerant (ZFT) separation systems. Currently, spacecraft and launch vehicle providers for both the Orion and Commercial Crew Programs (CCPs) plan to deviate from the heritage safety approach and NASA's SFT human rating requirements. Both programs' partners have base-lined ZFT frangible joints for vehicle staging and fairing separation. These joints are commercially available from pyrotechnic vendors. Non-human-rated missions have flown them numerous times. The joints are relatively easy to integrate structurally within the spacecraft. In addition, the separation event is debris free, and the resultant pyro shock is lower than that of other design solutions. It is, however, a serious deficiency to lack failure tolerance. When used for critical applications on human-rated vehicles, a single failure could potentially lead to loss of crew (LOC) or loss of mission (LOM)). The Engineering and Safety & Mission Assurance directorates within the NASA Johnson Space Center took action to address this safety issue by initiating a project to develop a fully redundant, SFT frangible joint design, known as the Flat H. Critical to the ability to retrofit on launch vehicles being developed, the SFT mechanisms must fit within the same

  18. A Review of Natural Joint Systems and Numerical Investigation of Bio-Inspired GFRP-to-Steel Joints

    Science.gov (United States)

    Avgoulas, Evangelos I.; Sutcliffe, Michael P. F.

    2016-01-01

    There are a great variety of joint types used in nature which can inspire engineering joints. In order to design such biomimetic joints, it is at first important to understand how biological joints work. A comprehensive literature review, considering natural joints from a mechanical point of view, was undertaken. This was used to develop a taxonomy based on the different methods/functions that nature successfully uses to attach dissimilar tissues. One of the key methods that nature uses to join dissimilar materials is a transitional zone of stiffness at the insertion site. This method was used to propose bio-inspired solutions with a transitional zone of stiffness at the joint site for several glass fibre reinforced plastic (GFRP) to steel adhesively bonded joint configurations. The transition zone was used to reduce the material stiffness mismatch of the joint parts. A numerical finite element model was used to identify the optimum variation in material stiffness that minimises potential failure of the joint. The best bio-inspired joints showed a 118% increase of joint strength compared to the standard joints. PMID:28773688

  19. Structural dynamic analysis of a ball joint

    Science.gov (United States)

    Hwang, Seok-Cheol; Lee, Kwon-Hee

    2012-11-01

    Ball joint is a rotating and swiveling element that is typically installed at the interface between two parts. In an automobile, the ball joint is the component that connects the control arms to the steering knuckle. The ball joint can also be installed in linkage systems for motion control applications. This paper describes the simulation strategy for a ball joint analysis, considering manufacturing process. Its manufacturing process can be divided into plugging and spinning. Then, the interested responses is selected as the stress distribution generated between its ball and bearing. In this paper, a commercial code of NX DAFUL using an implicit integration method is introduced to calculate the response. In addition, the gap analysis is performed to investigate the fitness, focusing on the response of the displacement of a ball stud. Also, the optimum design is suggested through case studies.

  20. Optimizing MRI of small joints and extremities.

    Science.gov (United States)

    Thomas, M S; Greenwood, R; Nolan, C; Malcolm, P N; Toms, A P

    2014-10-01

    Obtaining optimal images of small joints using magnetic resonance imaging (MRI) can be technically challenging. The aim of this review is to outline the practical aspects of MRI of small joints, with reference to the underlying physical principles. Although the most important contribution to successful imaging of small joints comes from the magnet field strength and design of the receiver coil, there are a number of factors to balance including the signal-to-noise ratio, image resolution, and acquisition times. We discuss strategies to minimize artefacts from movement, inhomogeneity, chemical shift, and fat suppression. As with all MRI, each strategy comes at a price, but the benefits and costs of each approach can be fine-tuned to each combination of joint, receiver coil, and MRI machine. Copyright © 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  1. Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides.

    Science.gov (United States)

    Rodriguez, Maria C; Yegorova, Svetlana; Pitteloud, Jean-Philippe; Chavaroche, Anais E; André, Sabine; Ardá, Ana; Minond, Dimitriy; Jiménez-Barbero, Jesús; Gabius, Hans-Joachim; Cudic, Mare

    2015-07-28

    A shift to short-chain glycans is an observed change in mucin-type O-glycosylation in premalignant and malignant epithelia. Given the evidence that human galectin-3 can interact with mucins and also weakly with free tumor-associated Thomsen-Friedenreich (TF) antigen (CD176), the study of its interaction with MUC1 (glyco)peptides is of biomedical relevance. Glycosylated MUC1 fragments that carry the TF antigen attached through either Thr or Ser side chains were synthesized using standard Fmoc-based automated solid-phase peptide chemistry. The dissociation constants (Kd) for interaction of galectin-3 and the glycosylated MUC1 fragments measured by isothermal titration calorimetry decreased up to 10 times in comparison to that of the free TF disaccharide. No binding was observed for the nonglycosylated control version of the MUC1 peptide. The most notable feature of the binding of MUC1 glycopeptides to galectin-3 was a shift from a favorable enthalpy to an entropy-driven binding process. The comparatively diminished enthalpy contribution to the free energy (ΔG) was compensated by a considerable gain in the entropic term. (1)H-(15)N heteronuclear single-quantum coherence spectroscopy nuclear magnetic resonance data reveal contact at the canonical site mainly by the glycan moiety of the MUC1 glycopeptide. Ligand-dependent differences in binding affinities were also confirmed by a novel assay for screening of low-affinity glycan-lectin interactions based on AlphaScreen technology. Another key finding is that the glycosylated MUC1 peptides exhibited activity in a concentration-dependent manner in cell-based assays revealing selectivity among human galectins. Thus, the presentation of this tumor-associated carbohydrate ligand by the natural peptide scaffold enhances its affinity, highlighting the significance of model studies of human lectins with synthetic glycopeptides.

  2. One-pot synthesis of pillar[n]arenes catalyzed by a minimum amount of TfOH and a solution-phase mechanistic study.

    Science.gov (United States)

    Wang, Kai; Tan, Li-Li; Chen, Dai-Xiong; Song, Nan; Xi, Guan; Zhang, Sean Xiao-An; Li, Chunju; Yang, Ying-Wei

    2012-12-21

    A practical and effective trifluoromethanesulfonic acid (TfOH)-catalyzed cyclooligomerization strategy was developed for the synthesis of functionalized pillar[n]arenes and copillar[5]arenes from 1,4-dialkoxybenzenes with paraformaldehyde under mild reaction conditions, and the reaction mechanism of solution-phase catalytic synthesis of pillararenes was investigated by room-temperature X-band ESR spectroscopy, mass spectroscopy, NMR and control experiments, suggesting a free radical process initially and a Friedel-Crafts alkylation process during the consequent coupling and ring-closure stage.

  3. Alteration of a single nucleotide allows efficient binding of H2TF1/KBF1 to the immunoglobulin kappa enhancer B motif.

    OpenAIRE

    Mauxion, F; Sen, R

    1989-01-01

    NF-kappa B (a protein present constitutively only in B cells) and H2TF1/KBF1 (a more ubiquitously distributed protein[s]) are two transcription factors that recognize very similar DNA sequences. However, the binding site associated with the kappa immunoglobulin gene enhancer (kappa B) is recognized predominantly by NF-kappa B. Using synthetically altered recognition sequences, we showed that the B-cell-specific NF-kappa B-binding site in the kappa enhancer can be converted to one that binds b...

  4. Appendicular joint dislocations.

    Science.gov (United States)

    Hindle, Paul; Davidson, Eleanor K; Biant, Leela C; Court-Brown, Charles M

    2013-08-01

    This study defines the incidence and epidemiology of joint dislocations and subluxations of the appendicular skeleton. All patients presenting acutely to hospital with a dislocation or subluxation of the appendicular skeleton from a defined population were included in the study. There were 974 dislocations or subluxations over one year between the 1st November 2008 and the 31st October 2009. There was an overall joint dislocation incidence of 157/10(5)/year (188/10(5)/year in males and 128/10(5)/year in females). Males demonstrated a bimodal distribution with a peak incidence of 446/10(5)/year at 15-24 years old and another of 349/10(5)/year in those over 90 years. Females demonstrate an increasing incidence from the seventh decade with a maximum incidence of 520/10(5)/year in those over 90 years. The most commonly affected joints are the glenohumeral (51.2/10(5)/year), the small joints of the hand (29.9/10(5)/year), the patellofemoral joint (21.6/10(5)/year), the prosthetic hip (19.0/10(5)/year), the ankle (11.5/10(5)/year), the acromioclavicular joint (8.9/10(5)/year) and the elbow (5.5/10(5)/year). Unlike fractures, dislocations are more common in the both the most affluent and the most socially deprived sections of the population. Joint disruptions are more common than previously estimated. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Tokamak Physics EXperiment (TPX): Toroidal field magnet design, development and manufacture. SDRL 15, System design description. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-22

    This System Design Description, prepared in accordance with the TPX Project Management Plan provides a summary or TF Magnet System design features at the conclusion of Phase I, Preliminary Design and Manufacturing Research. The document includes the analytical and experimental bases for the design, and plans for implementation in final design, manufacturing, test, and magnet integration into the tokamak. Requirements for operation and maintenance are outlined, and references to sources of additional information are provided.

  6. Acromioclavicular joint dislocations.

    Science.gov (United States)

    Babhulkar, Ashish; Pawaskar, Aditya

    2014-03-01

    Acromioclavicular (AC) dislocation is a common injury especially among sportsmen. There is still a lack of consensus on whether to conserve or operate type III AC joint dislocations. Even among surgeons inclined to operate AC joint dislocations there is no unanimity on which surgical technique. There are a plethora of choices between mechanical fixation or synthetic materials or biologic anatomic reconstructions. Even among surgeons, there is a choice between open repairs and the latest-arthroscopic reconstructions. This review of AC joint dislocations intends to analyze the available surgical options, a critical analysis of existing literature, actual technique of anatomic repair, and also accompanying complications.

  7. Anterior glenohumeral joint dislocations.

    Science.gov (United States)

    Dodson, Christopher C; Cordasco, Frank A

    2008-10-01

    The glenohumeral joint is the most mobile articulation in the body and the most commonly dislocated diarthroidal joint. Anterior dislocation is by far the most common direction and can lead to instability of the glenohumeral joint, which ranges from subtle increased laxity to recurrent dislocation. Overtime, understanding of anterior shoulder dislocations and the resulting instability has improved. Likewise, significant advances in arthroscopic equipment have allowed use of the arthroscope to address anatomically the various lesions that cause instability. This article reviews the anatomy, pathophysiology, clinical evaluation, and treatment of anterior shoulder instability.

  8. Joint by Design: The Western Desert Campaign

    Science.gov (United States)

    2015-05-21

    Introduction Seated in a dusty tent, finally cooling in the Egyptian night, the “Desert Fox” had a serious problem. German Lieutenant General Erwin...Ninth Air Force.” 8 foreign soil in Mexico and in Europe during the First World War, expeditionary operations in the Second World War had been...Benghazi and Tobruk, and the Egyptian port of Matruh were operating at 60 percent of their potential capacity. By the end of August, the Axis loss rate of

  9. Adaptive Control of Robotic arm with Hysteretic Joint

    OpenAIRE

    Kannan, Somasundar; Bezzaoucha, Souad; Quintanar Guzman, Serket; Olivares Mendez, Miguel Angel; Voos, Holger

    2016-01-01

    This article addresses the problem of control of robotic arm with a hysteretic joint behavior. The mechanical design of the one-degree of freedom robotic arm is presented where the joint is actuated by a Shape Memory Alloy (SMA) wire. The SMA wire based actuation of the joint makes the robotic arm lightweight but at the same time introduces hysteresis type nonlinearities. The nonlinear dynamic model of the robotic arm is introduced and an Adaptive control solution is pres...

  10. T-F and S/DOE Gladys McCall No. 1 well, Cameron Parish, Louisiana. Geopressured-geothermal well report, Volume II. Well workover and production testing, February 1982-October 1985. Final report. Part 1

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    The T-F and S/DOE Gladys McCall No. 1 well was the fourth in a series of wells in the DOE Design Wells Program that were drilled into deep, large geopressured-geothermal brine aquifers in order to provide basic data with which to determine the technological and economic viability of producing energy from these unconventional resources. This brine production well was spudded on May 27, 1981 and drilling operations were completed on November 2, 1981 after using 160 days of rig time. The well was drilled to a total depth of 16,510 feet. The target sands lie at a depth of 14,412 to 15,860 feet in the Fleming Formation of the lower Miocene. This report covers well production testing operations and necessary well workover operations during the February 1982 to October 1985 period. The primary goals of the well testing program were: (1) to determine reservoir size, shape, volume, drive mechanisms, and other reservoir parameters, (2) to determine and demonstrate the technological and economic viability of producing energy from a geopressured-geothermal brine aquifer through long-term production testing, and (3) to determine problem areas associated with such long-term production, and to develop solutions therefor.

  11. Joint Quantum Institute

    Data.gov (United States)

    Federal Laboratory Consortium — The Joint Quantum Institute (JQI) is pursuing that goal through the work of leading quantum scientists from the Department of Physics of the University of Maryland...

  12. Wrist joint assembly

    Science.gov (United States)

    Kersten, L.; Johnson, J. D. (Inventor)

    1978-01-01

    A wrist joint assembly is provided for use with a mechanical manipulator arm for finely positioning an end-effector carried by the wrist joint on the terminal end of the manipulator arm. The wrist joint assembly is pivotable about a first axis to produce a yaw motion, a second axis is to produce a pitch motion, and a third axis to produce a roll motion. The wrist joint assembly includes a disk segment affixed to the terminal end of the manipulator arm and a first housing member, a second housing member, and a third housing member. The third housing member and the mechanical end-effector are moved in the yaw, pitch, and roll motion. Drive means are provided for rotating each of the housings about their respective axis which includes a cluster of miniature motors having spur gears carried on the output drive shaft which mesh with a center drive gear affixed on the housing to be rotated.

  13. Distal radioulnar joint injuries

    National Research Council Canada - National Science Library

    Thomas, Binu P; Sreekanth, Raveendran

    2012-01-01

    .... Injuries around distal radioulnar joint are not uncommon, and are usually associated with distal radius fractures,fractures of the ulnar styloid and with the eponymous Galeazzi or Essex_Lopresti fractures...

  14. Joint Aspiration (Arthrocentesis)

    Science.gov (United States)

    ... include juvenile idiopathic arthritis (or JIA, formerly called rheumatoid arthritis, or JRA), systemic lupus erythematosus (SLE), and Lyme disease. Joint aspiration is diagnostic but it also can be therapeutic, helping to ...

  15. Improved orthopedic arm joint

    Science.gov (United States)

    Dane, D. H.

    1971-01-01

    Joint permits smooth and easy movement of disabled arm and is smaller, lighter and less expensive than previous models. Device is interchangeable and may be used on either arm at the shoulder or at the elbow.

  16. Resealing concrete pavement joints

    Science.gov (United States)

    1999-07-01

    The primary objective of this study was to evaluate the relative performance of the selected joint sealant materials. Other objectives were to determine the effect of selected sealant configurations and installation methods, and to identify sealant m...

  17. Concrete pavement joint deterioration.

    Science.gov (United States)

    2015-12-01

    Concrete pavements are an important part of our national infrastructure. In recent years the relatively small number of reported joints deteriorating prematurely in concrete pavements around Indiana has increased. Changes over the past 45 years in IN...

  18. Joint Services Electronics Program.

    Science.gov (United States)

    1983-09-30

    Compound Semiconductors." 4 ......... I-*. Univesity of California. Berkeley Electronics Research Laboratory Joint Services Electronics Program August 15...reduction techniques [SCH-66,MCG- 73,HAM-75], for essentially i educing the proportionality constant. A significant portion of the probabilistic literature

  19. Hip joint replacement

    Science.gov (United States)

    ... a part of the pelvic bone called the acetabulum) The upper end of the thighbone (called the ... Other reasons for replacing the hip joint are: Fractures in the thigh bone. Older adults often have ...

  20. Double-composite rectangular truss bridge and its joint analysis

    Directory of Open Access Journals (Sweden)

    Yongjian Liu

    2015-08-01

    Full Text Available This paper describes a novel composite tubular truss bridge with concrete slab and concrete-filled rectangular chords. With concrete slab plus truss system and joints reinforced with concrete and Perfobond Leiste rib, double composite truss bridge proved to be a fairly suitable solution in negative moment area. Perfobond Leiste shear connector (PBL is widely implemented in the composite structure for its outstanding fatigue resistance. In this pilot bridge, Perfobond Leister ribs (PBR were installed in the truss girder's joints, which played double roles as shear connector and stiffener. An erection method and overall bridge structural analysis were then presented. Typical joints in the pilot bridge were selected to analyze the effect of PBR. Investigation of the effect of PBR in concrete-filled tubular joints was elaborated. Comparison has revealed that concrete-filled tubular joints with PBR have much higher constraint capability than joints without PBR. For rectangular tubular truss, the punching shear force of the concrete filled joint with PBR is approximately 43% larger than that of the joint without PBR. Fatigue performance of the joint installed with PBR was improved, which was found through analysis of the stress concentration factor of joint. The PBR installed in the joints mitigated the stress concentration factor in the chord face. Therefore, the advantages of this new type of bridge are demonstrated, including the convenience of construction using rectangular truss, innovative concept of structural design and better global and local performances.

  1. Successfully Developing Joint Leaders

    Science.gov (United States)

    2005-05-13

    units” (HQ/USA, 1998, 4). For example, Infantrymen proceed to Fort Benning, Georgia, an Aviation officer to Fort Rucker , Alabama, an Armor officer...Supreme Command. New York, NY: Anchor Books, 2002. Colaizzi, Jennifer . “Pinnacle course offers two and three-star commanders joint education...Personal Interview. January 2005. Snider, Don M. “Jointess, Defense Transformation, and the Need for a New Joint Warfare Profession.” Parameters

  2. Steeper posterior tibial slope markedly increases ACL force in both active gait and passive knee joint under compression.

    Science.gov (United States)

    Marouane, H; Shirazi-Adl, A; Adouni, M; Hashemi, J

    2014-04-11

    The role of the posterior tibial slope (PTS) in anterior cruciate ligament (ACL) risk of injury has been supported by many imaging studies but refuted by some in vitro works. The current investigation was carried out to compute the effect of ±5(o) change in PTS on knee joint biomechanics in general and ACL force/strain in particular. Two validated finite element (FE) models of the knee joint were employed; one active lower extremity musculoskeletal model including a complex FE model of the knee joint driven by in vivo kinematics/kinetics collected in gait of asymptomatic subjects, and the other its isolated unconstrained passive tibiofemoral (TF) joint considered under 1400 N compression at four different knee flexion angles (0°-45°). In the TF model, the compression force was applied at the joint mechanical balance point causing no rotations in sagittal and frontal planes. Changes in PTS moderately affected muscle forces and joint contact forces at mid-stance period. Both active (at mid-stance) and passive (at all flexion angles) models showed a substantial increase in the anterior tibial translation and ACL force as PTS increased with reverse trends as PTS decreased. In the active model of gait at mid-stance, ACL force increased by 75% (from 181 N to 317 N) in steeper PTS but decreased by 44% (to 102 N) in flatter PTS. The posterolateral bundle of ACL carried the load at smaller flexion angles with a shift to its anteromedial bundle as flexion increased. In accordance with earlier imaging studies, greater PTS is a major risk factor for ACL rupture especially in activities involving large compression forces. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Bayesian Joint Modeling of Multiple Gene Networks and Diverse Genomic Data to Identify Target Genes of a Transcription Factor.

    Science.gov (United States)

    Wei, Peng; Pan, Wei

    2012-01-01

    We consider integrative modeling of multiple gene networks and diverse genomic data, including protein-DNA binding, gene expression and DNA sequence data, to accurately identify the regulatory target genes of a transcription factor (TF). Rather than treating all the genes equally and independently a priori in existing joint modeling approaches, we incorporate the biological prior knowledge that neighboring genes on a gene network tend to be (or not to be) regulated together by a TF. A key contribution of our work is that, to maximize the use of all existing biological knowledge, we allow incorporation of multiple gene networks into joint modeling of genomic data by introducing a mixture model based on the use of multiple Markov random fields (MRFs). Another important contribution of our work is to allow different genomic data to be correlated and to examine the validity and effect of the independence assumption as adopted in existing methods. Due to a fully Bayesian approach, inference about model parameters can be carried out based on MCMC samples. Application to an E. coli data set, together with simulation studies, demonstrates the utility and statistical efficiency gains with the proposed joint model.

  4. An analysis of factors causing the occurrence of off-design thermally induced force effects in the zone of weld joint no. 111-1 in a PGV-1000M steam generator and recommendations on excluding them

    Science.gov (United States)

    Bakirov, M. B.; Levchuk, V. I.; Povarov, V. P.; Gromov, A. F.

    2014-08-01

    Inadmissible operational flaws occurring in the critical zones of heat-transfer and mechanical equipment are commonly revealed in all nuclear power plant units both in Russia and abroad. The number of such flaws will only grow in the future because the majority of nuclear power plants have been in operation for a time that is either close to or even exceeds the assigned service life. In this connection, establishing cause-and-effect relations with regard to accelerated incipience and growth of flaws, working out compensating measures aimed at reducing operational damageability, and setting up monitoring of equipment integrity degradation of during operation are becoming the matters of utmost importance. There is a need to introduce new approaches to comprehensive diagnostics of the technical state of important nuclear power plant equipment, including continuous monitoring of its operational damageability and the extent of its loading in the most critical zones. Starting from 2011, such a monitoring system has successfully been used for the Novovoronezh NPP Unit 5 in the zone of weld joint no. 111-1 of steam generator no. 4. Based on the results from operation of this system in 2011-2013, unsteady thermally induced force effects (periodic thermal shocks and temperature abnormalities) were reveled, which had not been considered in the design, and which have an essential influence on the operational loading of this part. Based on an analysis of cause-and-effect relations pertinent to temperature abnormalities connected with technological operations, a set of measures aimed at reducing the thermally induced force loads exerted on pipeline sections was developed, which includes corrections to the process regulations for safe operation and to the operating manuals (involving changes in the algorithms for manipulating with the stop and control valves in the steam generator blowdown system).

  5. Furniture design

    CERN Document Server

    Smardzewski, Jerzy

    2015-01-01

    Maximizing reader insights into the principles of designing furniture as wooden structures, this book discusses issues related to the history of furniture structures, their classification and characteristics, ergonomic approaches to anthropometric requirements and safety of use. It presents key methods and highlights common errors in designing the characteristics of the materials, components, joints and structures, as well as looking at the challenges regarding developing associated design documentation. Including analysis of how designers may go about calculating the stiffness and endurance of parts, joints and whole structures, the book analyzes questions regarding the loss of furniture stability and the resulting threats to health of the user, putting forward a concept of furniture design as an engineering processes. Creating an attractive, functional, ergonomic and safe piece of furniture is not only the fruit of the work of individual architects and artists, but requires an effort of many people working ...

  6. The Standard Joint Unit.

    Science.gov (United States)

    Casajuana Kögel, Cristina; Balcells-Olivero, María Mercedes; López-Pelayo, Hugo; Miquel, Laia; Teixidó, Lídia; Colom, Joan; Nutt, David John; Rehm, Jürgen; Gual, Antoni

    2017-07-01

    Reliable data on cannabis quantities is required to improve assessment of cannabis consumption for epidemiological analysis and clinical assessment, consequently a Standard Joint Unit (SJU) based on quantity of 9-Tetrahydrocannabinol (9-THC) has been established. Naturalistic study of a convenience sample recruited from February 2015-June 2016 in universities, leisure spaces, mental health services and cannabis clubs in Barcelona. Adults, reporting cannabis use in the last 60 days, without cognitive impairment or language barriers, answered a questionnaire on cannabis use and were asked to donate a joint to further determine their 9-THC and Cannabidiol (CBD) content. 492 participants donated 315 valid joints. Donators were on average 29 years old, mostly men (77%), single (75%), with at least secondary studies (73%) and in active employment (63%). Marijuana joints (N=232) contained a median of 6.56mg of 9-THC (Interquartile range-IQR=10,22) and 0.02mg of CBD (IQR=0.02); hashish joints (N=83) a median of 7.94mg of 9-THC (IQR=10,61) and 3.24mg of CBD (IQR=3.21). Participants rolled 4 joints per gram of cannabis and paid 5€ per gram (median values). Consistent 9-THC-content in joints lead to a SJU of 7mg of 9-THC, the integer number closest to the median values shared by both cannabis types. Independently if marijuana or hashish, 1 SJU = 1 joint = 0.25 g of cannabis = 7 mg of 9-THC. For CBD, only hashish SJU contained relevant levels. Similarly to the Standard Drink Unit for alcohol, the SJU is useful for clinical, epidemiological and research purposes. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Detection of joint space narrowing in hand radiographs

    NARCIS (Netherlands)

    Bernelot Moens, H.J.; Kauffman, J.A.; Slump, Cornelis H.

    2006-01-01

    Background: Computer-aided or fully automated measurement of radiographic joint damage may help to overcome the limitations of such measurements by human experts. Objectives: To design an automated method for measuring the joint space width with a higher sensitivity to change than manual methods.

  8. Fatigue behaviour and ultimate capacity of grouted tubular joints

    NARCIS (Netherlands)

    Lalani, M.; Morahan, D.J.; Foeken, R.J. van; Wardenier, J.

    1996-01-01

    A Joint industry project (JIP) commenced in 1993(1) to develop a design manual for tubular joints which are strengthened or repaired through chord grout-filling. This project has been funded by five oil companies and two regulatory bodies. The project has comprised the conduct of over 150 Stress

  9. Joint hypermobility syndrome among undergraduate students | Didia ...

    African Journals Online (AJOL)

    Objective: To assess the prevalence of joint hypermobility syndrome among undergraduate students of the University of Port Harcourt, Nigeria using the Beighton's criteria. Design: Cross- sectional prospective study of 550 randomly selected undergraduate students . Setting: Departments of Anatomy and Human Physiology ...

  10. Multinational Companies And Joint Venture Investment ...

    African Journals Online (AJOL)

    This study brought to the fore, critical issues relating the Joint Venture Arrangement (JVA) prevailing in the Nigeria\\'s oil sector. The JVA option was considered the best alternative strategy for optimizing Nigeria\\'s oil returns and indigenous capacity building, since April 1971. questionnaire was designed and administered on ...

  11. Traumatic thumb carpometacarpal joint dislocations.

    Science.gov (United States)

    Bosmans, B; Verhofstad, M H J; Gosens, T

    2008-03-01

    Isolated traumatic dislocation of the thumb carpometacarpal joint, also called the trapeziometacarpal joint, is a rare injury. Controversy still exists concerning which ligaments are the true key stabilizers for the joint and therefore need to be damaged to result in dislocation, and optimal treatment strategies for thumb carpometacarpal joint dislocations are the subject of continuing debate. We give a review of the literature concerning traumatic dislocations of the carpometacarpal joint of the thumb and propose a treatment algorithm.

  12. Static Stiffness Modeling of Parallel Kinematics Machine Tool Joints

    Directory of Open Access Journals (Sweden)

    O. K. Akmaev

    2015-09-01

    Full Text Available The possible variants of an original parallel kinematics machine-tool structure are explored in this article. A new Hooke's universal joint design based on needle roller bearings with the ability of a preload setting is proposed. The bearing stiffness modeling is carried out using a variety of methods. The elastic deformation modeling of a Hook’s joint and a spherical rolling joint have been developed to assess the possibility of using these joints in machine tools with parallel kinematics.

  13. Size effect of welded thin-walled tubular joints

    OpenAIRE

    Mashiri, Fidelis Rutendo; Zhao, Xiao-Ling; Hirt, Manfred A.; NUSSBAUMER, Alain

    2007-01-01

    This paper clarifies the terminologies used to describe the size effect on fatigue behaviour of welded joints. It summarizes the existing research on size effect in the perspective of newly defined terminologies. It identifies knowledge gaps in designing tubular joints using the hot spot stress method, i.e. thin-walled tubular joints with wall thickness less than 4 mm and thick-walled tubular joints with wall thickness larger than 50 mm or diameter to thickness ratio less than 24. It is the t...

  14. Temporomandibular joint examination reviewed

    Directory of Open Access Journals (Sweden)

    L. Guarda Nardini

    2011-09-01

    Full Text Available The temporo-mandibular joint (TMJ it’s a joint closely related to the skull base, the spine, and the jaws; all these anatomical structures must be taken in consideration when evaluating pain involving the tmj. In order to detect patients affected by pathology or dysfunctions of the tmj, physical examination is of great value in orienting the diagnosis. Inspection must consider the symmetry of the body, the dental status and the type of occlusion. Palpation is a way to assess contractiont involving the muscles of the masticatory system and of the neck. Auscultation, based on articular noise provides means to determine whether we are dealing with degeneration of the joint or a dislocation of the intrarticular disc. In order to confirm the diagnosis obtained with the clinical evaluation, it’s useful to perform imaging techniques as opt, tomography and TC of the tmj and electromyokineosiography – index of the mandibular functionality and of the muscles status. MRI and dynamic MRI are among the non invasive exams which give the greatest amount of information, regarding the disc position and the joint degeneration. Arthroscopy is an invasive technique that allows early diagnosis of degeneration and is helpful to reveal early inflammatory processes of the joint.

  15. Dissimilar metals joint evaluation

    Science.gov (United States)

    Wakefield, M. E.; Apodaca, L. E.

    1974-01-01

    Dissimilar metals tubular joints between 2219-T851 aluminum alloy and 304L stainless steel were fabricated and tested to evaluate bonding processes. Joints were fabricated by four processes: (1) inertia (friction) weldings, where the metals are spun and forced together to create the weld; (2) explosive welding, where the metals are impacted together at high velocity; (3) co-extrusion, where the metals are extruded in contact at high temperature to promote diffusion; and (4) swaging, where residual stresses in the metals after a stretching operation maintain forced contact in mutual shear areas. Fifteen joints of each type were prepared and evaluated in a 6.35 cm (2.50 in.) O.D. size, with 0.32 cm (0.13 in.) wall thickness, and 7.6 cm (3.0 in) total length. The joints were tested to evaluate their ability to withstand pressure cycle, thermal cycle, galvanic corrosion and burst tests. Leakage tests and other non-destructive test techniques were used to evaluate the behavior of the joints, and the microstructure of the bond areas was analyzed.

  16. Heterotopic Vascularized Joint Transfer in Mutilating Hand Injuries.

    Science.gov (United States)

    Chang, Nai-Jen; Chang, Johnny T; Hsu, Chung-Chen; Lin, Cheng-Hung; Lin, Chih-Hung; Lin, Yu-Te

    2016-03-01

    In cases of mutilating hand injuries, the primary goal is recovery of prehensile function. This is particularly true in the case of joints, which are extremely difficult to replace or reconstruct adequately when damaged. Heterotopic vascularized joint transfer is indicated when salvageable joints are available for transfer to a more functionally optimal position on the hand. Seven cases of mutilating hand injuries treated with heterotopic vascularized joint transfers from 2003 to 2012 were retrospectively identified. All patients sustained severe metacarpophalangeal joint (MPJ) or proximal interphalangeal joint (PIPJ) damage that threatened recovery of optimal hand function. All patients were men, with an average age of 34.7 years. Operative, perioperative, and postoperative details including final active range of motion were collected and analyzed. Seven joints were taken from nonsalvageable amputated digits: 4 from the amputated parts, and 3 from the proximal stumps. Five joints were transferred as free flaps requiring microvascular anastomosis, and 2 were transferred on neurovascular pedicles. One joint was lost due to vasospasm. Average active range of motion was 68.3° for homojoint transfers (MPJ to MPJ, PIPJ to PIPJ), and 35° for heterojoint transfers. All but 1 patient were able to achieve tripod pinch; the remaining patient achieved only side-to-side pinch. Heterotopic vascularized joint transfer is a useful technique to consider in cases of mutilating hand injuries. Improved recovery of prehensile function can be achieved with thoughtful design and execution, followed by proper patient education and rehabilitation.

  17. A novel hybrid joining methodology for composite to steel joints

    Science.gov (United States)

    Sarh, Bastian

    This research has established a novel approach for designing, analyzing, and fabricating load bearing structural connections between resin infused composite materials and components made of steel or other metals or alloys. A design philosophy is proposed wherein overlapping joint sections comprised of fiber reinforced plastics (FRP's) and steel members are connected via a combination of adhesive bonding and integrally placed composite pins. A film adhesive is utilized, placed into the dry stack prior to resin infusion and is cured after infusion through either local heat elements or by placing the structure into an oven. The novel manner in which the composite pins are introduced consists of perforating the steel member with holes and placing pre-formed composite pins through them, also prior to resin infusion of the composite section. In this manner joints are co-molded structures such that secondary processing is eliminated. It is shown that such joints blend the structural benefits of adhesive and mechanically connected joints, and that the fabrication process is feasible for low-cost, large-scale production as applicable to the shipbuilding industry. Analysis procedures used for designing such joints are presented consisting of an adhesive joint design theory and a pin placement theory. These analysis tools are used in the design of specimens, specific designs are fabricated, and these evaluated through structural tests. Structural tests include quasi-static loading and low cycle fatigue evaluation. This research has thereby invented a novel philosophy on joints, created the manufacturing technique for fabricating such joints, established simple to apply analysis procedures used in the design of such joints (consisting of both an adhesive and a pin placement analysis), and has validated the methodology through specimen fabrication and testing.

  18. Ka-band waveguide rotary joint

    KAUST Repository

    Yevdokymov, Anatoliy

    2013-04-11

    The authors present a design of a waveguide rotary joint operating in Ka-band with central frequency of 33 GHz, which also acts as an antenna mount. The main unit consists of two flanges with a clearance between them; one of the flanges has three circular choke grooves. Utilisation of three choke grooves allows larger operating clearance. Two prototypes of the rotary joint have been manufactured and experimentally studied. The observed loss is from 0.4 to 0.8 dB in 1.5 GHz band.

  19. Method of superconducting joint and its measurement

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woo Gon; Lee, Ho Jin; Hong, Gye Won [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1994-04-01

    The development of joint techniques for superconducting wires is essential to fabricate the high quality superconducting magnet. In this report, the various joining methods and their measuring techniques were reviewed. In order to fabricate a precise superconducting magnet, joining and measuring experiment by using the field decay technique carried out. The contact resistance of coupled specimens with joint was measured as 3.0 x 10{sup -15} ohm at 1 Tesla which is lower than that of the real operating condition of MRI magnet. It is expected that these data can be used to design and fabricate the superconducting magnets successfully. (Author) 12 refs., 20 figs., 2 tabs.

  20. Transversely Compressed Bonded Joints

    DEFF Research Database (Denmark)

    Hansen, Christian Skodborg; Schmidt, Jacob Wittrup; Stang, Henrik

    2012-01-01

    The load capacity of bonded joints can be increased if transverse pressure is applied at the interface. The transverse pressure is assumed to introduce a Coulomb-friction contribution to the cohesive law for the interface. Response and load capacity for a bonded single-lap joint was derived using...... non-linear fracture mechanics. The results indicated a good correlation between theory and tests. Furthermore, the model is suggested as theoretical base for determining load capacity of bonded anchorages with transverse pressure, in externally reinforced concrete structures....

  1. Temporomandibular joint examination reviewed

    OpenAIRE

    L. Guarda Nardini

    2011-01-01

    The temporo-mandibular joint (TMJ) it’s a joint closely related to the skull base, the spine, and the jaws; all these anatomical structures must be taken in consideration when evaluating pain involving the tmj. In order to detect patients affected by pathology or dysfunctions of the tmj, physical examination is of great value in orienting the diagnosis. Inspection must consider the symmetry of the body, the dental status and the type of occlusion. Palpation is a way to assess contractiont inv...

  2. JOINT INVOLVEMENT IN SYPHILIS

    Directory of Open Access Journals (Sweden)

    T. I. Zlobina

    2016-01-01

    Full Text Available Joint involvement in syphilis has been considered as casuistry in recent years. At the same time, the high incidence of primary syphilis and the notified cases of late neurosyphilis may suggest that joint involvement in this disease is by no means always verified. Traditionally there are two forms of syphilitic arthritis: primary synovial (involving the articular membranes and sac and primary bone (involving the articular bones and cartilages ones. The paper describes the authors' clinical case of the primary bone form of articular syphilis in a 34-year-old man. 

  3. Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children

    DEFF Research Database (Denmark)

    Bashamboo, Anu; Eozenou, Caroline; Jorgensen, Anne

    2018-01-01

    Emerging evidence from murine studies suggests that mammalian sex determination is the outcome of an imbalance between mutually antagonistic male and female regulatory networks that canalize development down one pathway while actively repressing the other. However, in contrast to testis formation......, the gene regulatory pathways governing mammalian ovary development have remained elusive. We performed exome or Sanger sequencing on 79 46,XX SRY-negative individuals with either unexplained virilization or with testicular/ovotesticular disorders/differences of sex development (TDSD/OTDSD). We identified...... establish COUP-TF2 as a human "pro-ovary" and "anti-testis" sex-determining factor in female gonads. Furthermore, the data presented here provide additional evidence of the emerging importance of nuclear receptors in establishing human ovarian identity and indicate that nuclear receptors may have divergent...

  4. Comparison of different tube-of-response (TOR) models for resolution recovery in PET image reconstruction for the Philips Ingenuity TF PET/MR

    Energy Technology Data Exchange (ETDEWEB)

    Lougovski, Alexandr; Hofheinz, Frank; Van Den Hoff, Jorg [Helmholtz-Center Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, PET Center, Dresden (Germany)

    2015-05-18

    Recently, we have proposed a method for on-the-fly system matrix computation where the tube-of-response (TOR) is approximated as a cylinder with constant density (TORCD) and the cubic voxels are replaced by spheres. We could show that with this model the PET image quality can be notably improved compared to the vendor provided image reconstruction of our Philips Ingenuity-TF PET/MR. In this work we address the question whether image quality can be further improved by using a variable density TOR (TOR-VD). The radial variability of TOR-VD was modelled by a Kaiser-Bessel function. Free parameters of this density model were used to optimize image properties regarding resolution, noise, and Gibbs artifacts. Additional, a TOR-VD model accounting for position dependent effects along the TOR caused by the finite solid angles of the detectors is under investigation. Phantom measurement were performed with a Philips Ingenuity-TF PET/MR scanner. Listmode data were reconstructed using TOR-CD and TORVD, respectively on two different grids with cubic voxel size of 2 mm and 4 mm. Image quality was assessed with resolution-noise curves and investigation of the radial position dependence of the spatial resolution. For 2 mm voxels, TOR-VD consistently yields a slight improvement of the investigated image quality measures compared to TOR-CD. For 4 mm voxels both models lead essentially to the same results. These findings can be understood as a consequence of the relative size of voxel and TOR. For typical whole body studies (4 mm voxel size) a variable TOR does not improve image quality beyond what is achievable with a constant density TOR. For smaller voxel size the image quality can indeed be somewhat improved with a variable TOR but at the expense of drastically increased computation time.

  5. MIN3P-Thcm Reactive Transport Modelling in Low Permeability Media - Mont Terri in-Situ Diffusion Experiments and EBS-TF-C Benchmarks

    Science.gov (United States)

    Xie, M.; Rasouli, P.; Mayer, K. U.; MacQuarrie, K. T. B.

    2014-12-01

    Reactive transport modelling is one method for assessing long-term geochemical processes influencing radionuclide mobility in geologic formations considered for implementation of the multi-barrier deep geologic repository concept. A key issue revolves around the quantitative prediction and assessment of solute migration and retardation through engineered and enclosing natural barriers. The reactive transport code MIN3P-THCm, with several code enhancements (i.e., multisite ion exchange, multicomponent diffusion and hybrid multicomponent diffusion models), was used to simulate a series of benchmarking problems, laboratory experiments, and in-situ diffusion experiments in the framework of the Mont Terri and EBS-TF-C projects. For the Mont Terri project, excellent agreement was achieved with other groups for the generic benchmarking simulations. Additional simulations were undertaken to reproduce in-situ borehole diffusion experiments using parameters determined through laboratory experiments. Comparison of the simulated and the in-situ borehole diffusion data showed: good agreement for HTO, anions, weakly sorbing tracers and major ions, but some discrepancies for strongly sorbing tracers. Sensitivity analysis revealed that a scenario in which the borehole filter is assumed to be partially filled with dispersed fine clay particles originating from the host rock might explain the rapid concentration decrease of strongly sorbing tracers in the borehole solution. For the EBS-TF-C project, comparison of simulated and experimental data shows very good agreement for cases involving conservative transport and anion migration. Excellent agreement was also obtained for cation migration in comparison to other established reactive transport codes; however, some discrepancies remain between observed and simulated data. In the future, continued development of conceptual models and numerical implementations could lead to further improvements in mechanistic descriptions of strongly

  6. Calculating Parameters for a ReBCO Cable Joint Terminal

    CERN Document Server

    Vipp, Venno

    2016-01-01

    The aim of this project was to evaluate the effects of temperature and length on the design of a joint for a 6-around 1 CORC based conductor and optimize the terminal geometry for a single strand cable.

  7. Joint Strike Fighter fit for duty in Europe?

    NARCIS (Netherlands)

    Heerkens, Johannes M.G.

    2000-01-01

    Focuses on the potential growth of the Joint Strike Fighter (JSF) market in Europe. Competition between Lockheed Martin and Boeing for the fighter's design contract; Disadvantages of the fighter plane; Stealth performance of JSF.

  8. Imaging the temporomandibular joint

    Energy Technology Data Exchange (ETDEWEB)

    Katzberg, R.W.; Manzione, J.V.; Westesson, P.L.

    1988-01-01

    This book encompasses all imaging modalities as they apply to the Temporomandibular Joint and its disorders. The volume employs correlative line drawings to elaborate on diagnostic images. It helps teach methods of TMJ imaging and describes findings identified by different imaging modalities to both radiologists and dental clinicians.

  9. Phenomenology of Joint Attention

    African Journals Online (AJOL)

    denise

    of phenomenology by offering a phenomenology of joint attention. The first section reviews elementary. Husserlian phenomenology and introduces a system for symbolically representing the structure of intentional mental states. The second section summarizes Edith Stein's phenomenological description of empathy, the ...

  10. Acromioclavicular Joint Separations

    Science.gov (United States)

    2013-01-01

    injuries. The sports most likely to cause AC joint dislocations are football, soccer, hockey, rugby , and skiing, among others [9, 28, 29]. The major cause...resected end of the distal clavicle was first described by Weaver and Dunn in 1972 [10]. However, the value of this technique has been ques- tioned since

  11. Joint Robotics Program

    Science.gov (United States)

    2008-04-23

    Kotler , P.M. (1997). Marketing management : Analysis, planning, implementation, and control. Upper Saddle River, NJ: Prentice Hall...collaborations which can identify better solutions and practices in acquisition, contract, financial, logistics and program management . For further...Project Manager , Robotics Joint Project Introduction Sun Tzu wrote first about the importance of logistics over two thousand years ago (Griffith

  12. Temporomandibular Joint Septic Arthritis

    Directory of Open Access Journals (Sweden)

    Gianfranco Frojo, MD

    2018-01-01

    Full Text Available Summary:. Infection of the temporomandibular joint (TMJ is a rare pediatric condition resulting from the introduction of pathogens into the joint by hematogenous seeding, local extension, or trauma. Early recognition of the typical signs and symptoms including fever, trismus, preauricular swelling, and TMJ region tenderness are critical in order to initiate further evaluation and prevent feared complications of fibrosis, ankylosis, abnormal facial structure, or persistence of symptoms. Contrast-enhanced computed tomography with ancillary laboratory analysis including erythrocyte sedimentation rate, C-reactive protein, and white blood cell count are beneficial in confirming the suspected diagnosis and monitoring response to therapy. Initial intervention should include empiric parenteral antibiotics, early mandibular mobilization, and joint decompression to provide synovial fluid for analysis including cultures. This report describes a case of TMJ bacterial arthritis in a healthy 6-year-old male who was promptly treated nonsurgically with intravenous antibiotics and localized needle joint decompression with return to normal function after completion of oral antibiotics and physical therapy.

  13. Jointness: A Selected Bibliography

    Science.gov (United States)

    2010-12-01

    Durell Young, and S. Rebecca Zimmerman . What It Takes: Air Force Command of Joint Operations. Santa Monica: RAND, 2009. 110pp. (U260 .S63 2009...2009. 64pp. http://handle.dtic.mil/100.2/ADA513467 McCaffrey, Rachel A. Reciprocally Embedding ISR [Intelligence, Surveillance, and Reconnaissance

  14. Joint Custody and Coparenting.

    Science.gov (United States)

    Sell, Kenneth D.

    Results are presented of an intensive search of U.S. newspapers and periodicals on the joint custody of children after divorce, where both parents have continued responsibility for parenting and where the children spend part of each week, month, or year with both of the parents. Areas of concern addressed by these materials include the following:…

  15. Joint-Use Libraries

    Science.gov (United States)

    Casstevens, Susan

    2017-01-01

    The joint-use library is a place where people of all ages, interests, and income levels can find items of interest at no personal cost. The mission of A. H. Meadows Public and High School Library in Midlothian, Texas, is to offer what other public libraries provide: educational and entertainment resources to a community. Yet, the staff also wants…

  16. Posterolateral elbow joint instability

    DEFF Research Database (Denmark)

    Olsen, Bo Sanderhoff; Søjbjerg, Jens Ole; Nielsen, K K

    1998-01-01

    Thirty-five osteoligamentous elbows were included in a study on the kinematics of posterolateral elbow joint instability during the pivot shift test (PST) before and after separate ligament cuttings in the lateral collateral ligament complex (LCLC). Division of the annular ligament or the lateral...

  17. Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF.

    Science.gov (United States)

    Tinholt, Mari; Vollan, Hans Kristian Moen; Sahlberg, Kristine Kleivi; Jernström, Sandra; Kaveh, Fatemeh; Lingjærde, Ole Christian; Kåresen, Rolf; Sauer, Torill; Kristensen, Vessela; Børresen-Dale, Anne-Lise; Sandset, Per Morten; Iversen, Nina

    2015-03-26

    Hypercoagulability in malignancy increases the risk of thrombosis, but is also involved in cancer progression. Experimental studies suggest that tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are involved in cancer biology as a tumor- promoter and suppressor, respectively, but the clinical significance is less clear. Here, we aimed to investigate the clinical relevance of TF and TFPI genetic and phenotypic diversity in breast cancer. The relationship between tumor messenger RNA (mRNA) expression and plasma levels of TF and TFPI (α and β), tagging single nucleotide polymorphisms (tagSNPs) in F3 (TF) (n=6) and TFPI (n=18), and clinicopathological characteristics and molecular tumor subtypes were explored in 152 treatment naive breast cancer patients. The effect of tumor expressed TF and TFPIα and TFPIβ on survival was investigated in a merged breast cancer dataset of 1881 patients. Progesterone receptor negative patients had higher mRNA expression of total TFPI (α+β) (P=0.021) and TFPIβ (P=0.014) in tumors. TF mRNA expression was decreased in grade 3 tumors (P=0.003). In plasma, total TFPI levels were decreased in patients with larger tumors (P=0.013). SNP haplotypes of TFPI, but not TF, were associated with specific clinicopathological characteristics like tumor size (odds ratio (OR) 3.14, P=0.004), triple negativity (OR 2.4, P=0.004), lymph node spread (OR 3.34, P=0.006), and basal-like (OR 2.3, P=0.011) and luminal B (OR 3.5, P=0.005) molecular tumor subtypes. Increased expression levels of TFPIα and TFPIβ in breast tumors were associated with better outcome in all tumor subtypes combined (P=0.007 and P=0.005) and in multiple subgroups, including lymph node positive subjects (P=0.006 and P=0.034). This study indicates that genetic and phenotypic variation of both TFPIα and TFPIβ, more than TF, are markers of cancer progression. Together with the previously demonstrated tumor suppressor effects of TFPI, the beneficial effect of tumor

  18. Adaptive plasticity in mammalian masticatory joints

    Science.gov (United States)

    Ravosa, Matthew J.; Kunwar, Ravinder; Nicholson, Elisabeth K.; Klopp, Emily B.; Pinchoff, Jessie; Stock, Stuart R.; Stack, M. Sharon; Hamrick, Mark W.

    2006-08-01

    Genetically similar white rabbits raised on diets of different mechanical properties, as well as wild-type and myostatin-deficient mice raised on similar diets, were compared to assess the postweaning effects of elevated masticatory loads due to increased jaw-adductor muscle and bite forces on the proportions and properties of the mandibular symphysis and temporomandibular joint (TMJ). Microcomputed tomography (microCT) was used to quantify bone structure at a series of equidistant external and internal sites in coronal sections for a series of joint locations. Discriminant function analyses and non-parametric ANOVAs were used to characterize variation in biomineralization within and between loading cohorts. In both species, long-term excessive loading results in larger joint proportions, thicker articular and cortical bone, and increased biomineralization of hard tissues. Such adaptive plasticity appears designed to maintain the postnatal integrity of masticatory joint systems for a primary loading environment(s). This behavioral signal may be increasingly mitigated in older organisms by the interplay between adaptive and degradative joint tissue responses.

  19. [A robot measurement system for spacesuit joint torque].

    Science.gov (United States)

    Du, Li-Bin; Gao, Xiao-Hui; Liu, Hong; Li, Tan-qiu

    2003-06-01

    To measure the joint torque of spacesuit so as to evaluate its dynamic force/torque performance. A method for measuring the spacesuit joint torque by use of robot technology was proposed in this paper. The design of the measuring strategy and measuring robot was put forward and a mathematical model of the system was given. Then the working space of the robot was analyzed. The robot designed is light, compact, easy to operate, and has a large working space. Experimental results demonstrated the effectiveness of the measuring principle and the reliability of the measuring system. The system can satisfy the requirements of the spacesuit joint torque measurement.

  20. Three-dimensional submodel for modelling of joints in precast concrete structures

    DEFF Research Database (Denmark)

    Herfelt, Morten Andersen; Poulsen, Peter Noe; Hoang, Linh Cao

    2016-01-01

    The shear capacity of in-situ cast joints is crucial to the overall stability of precast concrete structures. The current design is based on empirical formulas, which account for neither the reinforcement layout of the joint nor the three-dimensional stress states present within the joint...

  1. Differential Inverse Kinematics of a Redundant 4R Exoskeleton Shoulder Joint

    NARCIS (Netherlands)

    Keemink, A.Q.L.; van Oort, G.; Wessels, M.; Stienen, A.

    2017-01-01

    Most active upper-extremity rehabilitation exoskeleton designs incorporate a 3R rotational shoulder joint with orthogonal axes. This kind of joint has poor conditioning close to singular configurations when all joint axes become coplanar, which reduces its effective range of motion. We investigate

  2. In-vivo range of motion of the subtalar joint using computed tomography

    NARCIS (Netherlands)

    Beimers, Lijkele; Tuijthof, Gabriëlle Josephine Maria; Blankevoort, Leendert; Jonges, Remmet; Maas, Mario; van Dijk, C. Niek

    2008-01-01

    Understanding in vivo subtalar joint kinematics is important for evaluation of subtalar joint instability, the design of a subtalar prosthesis and for analysing surgical procedures of the ankle and hindfoot. No accurate data are available on the normal range of subtalar joint motion. The purpose of

  3. Improving the fatigue resistance of adhesive joints in laminated wood structures

    Science.gov (United States)

    Laufenberg, Theodore L.; River, Bryan H.; Murmanis, Lidija L.; Christiansen, Alfred W.

    1988-01-01

    The premature fatigue failure of a laminated wood/epoxy test beam containing a cross section finger joint was the subject of a multi-disciplinary investigation. The primary objectives were to identify the failure mechanisms which occurred during the finger joint test and to provide avenues for general improvements in the design and fabrication of adhesive joints in laminated wood structures.

  4. TPX: Contractor preliminary design review. Volume 3, Design and analysis

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-30

    Several models have been formed for investigating the maximum electromagnetic loading and magnetic field levels associated with the Tokamak Physics eXperiment (TPX) superconducting Poloidal Field (PF) coils. The analyses have been performed to support the design of the individual fourteen hoop coils forming the PF system. The coils have been sub-divided into three coil systems consisting of the central solenoid (CS), PF5 coils, and the larger radius PF6 and PF7 coils. Various electromagnetic analyses have been performed to determine the electromagnetic loadings that the coils will experience during normal operating conditions, plasma disruptions, and fault conditions. The loadings are presented as net body forces acting individual coils, spatial variations throughout the coil cross section, and force variations along the path of the conductor due to interactions with the TF coils. Three refined electromagnetic models of the PF coil system that include a turn-by-turn description of the fields and forces during a worst case event are presented in this report. A global model including both the TF and PF system was formed to obtain the force variations along the path of the PF conductors resulting from interactions with the TF currents. In addition to spatial variations, the loadings are further subdivided into time-varying and steady components so that structural fatigue issues can be addressed by designers and analysts. Other electromagnetic design issues such as the impact of the detailed coil designs on field errors are addressed in this report. Coil features that are analyzed include radial transitions via short jogs vs. spiral type windings and the effects of layer-to-layer rotations (i.e clocking) on the field errors.

  5. Acupuncture for peripheral joint osteoarthritis.

    NARCIS (Netherlands)

    Manheimer, Eric; Cheng, K.; Linde, Klaus; Lao, Lixing; Yoo, Junghee; Wieland, Susan; van der Windt, Daniëlle Awm; Berman, Brian M.; Bouter, Lex M.

    2010-01-01

    BACKGROUND: Peripheral joint osteoarthritis is a major cause of pain and functional limitation. Few treatments are safe and effective. OBJECTIVES: To assess the effects of acupuncture for treating peripheral joint osteoarthritis. SEARCH STRATEGY: We searched the Cochrane Central Register of

  6. Steroid injections - tendon, bursa, joint

    Science.gov (United States)

    ... gov/ency/article/007678.htm Steroid injections - tendon, bursa, joint To use the sharing features on this ... can be injected into a joint, tendon, or bursa. Description Your health care provider inserts a small ...

  7. New damage-sensitive feature for structures with bolted joints

    Science.gov (United States)

    Luo, W. F.; Yu, L.

    2017-05-01

    Compared with riveted and welded joints, bolted joints have advantages of easily dismantled, high load carrying and load-transferring capacity. However, bolted joints are also weaker components of assembled structures. Structural damage detection (SDD) on bolted joints is much required in the field of structural health monitoring (SHM). A new SDD method is proposed for damage identification of structures with bolted joints based on residual error of AR model in time series analysis. Firstly, a new data standardization process is defined to maintain the information of damage location. Then, a new structural damage feature sensitive to structural damage is developed based on the standard deviation of AR model residual errors. To verify the proposed method, a bolted joint structure is designed and fabricated in laboratory, connection damages of structures are simulated by loosening the bolted joints. The acceleration responses of structures with bolted joints under healthy and damage cases are acquired. Finally, the SDD is performed by traditional DSF and the new DSF. The illustrated results show that the proposed method is a hybrid tool for the bolted joint damage detection with the new damage-sensitive feature. In addition, some related issues will be discussed as well.

  8. Nonrigid external fixation of the elbow, coxofemoral, and tarsal joints in dogs.

    Science.gov (United States)

    Schwartz, Zeev; Griffon, Dominique

    2008-12-01

    Nonrigid external fixation of a joint is designed to restrict abnormal joint movement and facilitate healing of traumatized ligaments and capsule tissue with minimizing the impact of immobilization on articular homeostasis and cartilage metabolism. Weight bearing and joint motion minimize muscle atrophy and loss of bone mineral and allow controlled loading of the ligaments, thereby improving their strength and functionality. This article describes simple, cost effective techniques for the percutaneous application of external fixators to the elbow, coxofemoral, and tarsal joint of dogs.

  9. A Simulation to Evaluate Joint Military Logistics in a Humanitarian Assistance Environment

    Science.gov (United States)

    2012-03-01

    insight on the world of computer simulation. Furthermore, I thank the Center for Operational Analysis support team, for assisting me in getting over...Joint Assesment Team JDDOC Joint Deployment and Distribution Operations Center JFAST Joint Flow and Analysis System for Transportation JP Joint...step in the author’s research effort. Simulation Simulation is the process of designing and creating a computerized model of a real or proposed

  10. Does damage accumulate in timber joints loaded at load levels below 50% of the average short term strength?

    NARCIS (Netherlands)

    Kuilen, J.W.G. van de; Blass, H.J.

    1996-01-01

    Joints govern the design of many types of timber structures. Knowledge about the long term strength is limited. The long term behaviour of joints in is not necessarily the same as for timber, although many design codes give the same load duration factors for timber and joints. This study is focussed

  11. Peripheral degenerative joint diseases

    Directory of Open Access Journals (Sweden)

    Nilzio Antonio da Silva

    2008-03-01

    Full Text Available Osteoarthritis, a degenerative joint disease, is the most commonrheumatic disorder mainly in a geriatric population. Manifestationsare pain, stiffness and functional loss in the affected joint.According to etiology it is classifi ed as primary (or idiopathicand secondary. Some risk factors for disease development aregenetics, race, age, sex, obesity, occupational activities andarticular biomechanics. Pathogenesis is the same for any cause orlocalization, being catabolic alterations, with synthesis, inhibitionand reparing intent of the cartilage matrix. Metalloproteinases andcytokines (IL-1,IL-6,TNF-α actions promote infl ammatory reactionand cartilage degradation. Pain, the most important symptom,does not correlate with radiologic fi ndings. Peripheral osteoarthritisoccurs predominantly in the knee, hip and hand. Diagnosis is basedon clinical features, laboratorial tests and radiological changes.Rheumatological associations’ guidelines for treatment includenon-pharmacologic (education, physiotherapy, assistive devices,and pharmacologic (analgesics, anti-infl ammatory drugs therapyand surgery. Arthroplasty seems to work better than medicines, butshould be used if other treatments have failed.

  12. Temporomandibular joint disorder (review).

    Science.gov (United States)

    Dugashvili, G; Menabde, G; Janelidze, M; Chichua, Z; Amiranashvili, I

    2013-02-01

    Etiopathogenesis and clinical management of TMJD integrates a number of medical disciplines. In particular, dentistry, oral - facial surgery, neurology, rheumatology and so on. Nowadays there is no unified strategy for the management of this disease. Most cases of temporomandibular disorder (TMD) respond to simple treatment and the prognosis is good. Symptoms usually remit with simple care. In cases of secondary involvement of temporomandibular joint (TMJ), the prognosis depends on the primary disease. A comprehensive, chronological history and physical and examination of the patient, including dental history and examination, is essential to diagnose the specific condition to decide further investigations, if any, and to provide specific treatment. in severe cases, a joint consultation of a dentist, neurologist and rheumatologist is needed.

  13. Joint International Accelerator School

    CERN Multimedia

    CERN Accelerator School

    2014-01-01

    The CERN and US Particle Accelerator Schools recently organised a Joint International Accelerator School on Beam Loss and Accelerator Protection, held at the Hyatt Regency Hotel, Newport Beach, California, USA from 5-14 November 2014. This Joint School was the 13th in a series of such schools, which started in 1985 and also involves the accelerator communities in Japan and Russia.   Photo courtesy of Alfonse Pham, Michigan State University.   The school attracted 58 participants representing 22 different nationalities, with around half from Europe and the other half from Asia and the Americas. The programme comprised 26 lectures, each of 90 minutes, and 13 hours of case study. The students were given homework each day and had an opportunity to sit a final exam, which counted towards university credit. Feedback from the participants was extremely positive, praising the expertise and enthusiasm of the lecturers, as well as the high standard and quality of their lectures. Initial dis...

  14. Outpatient Total Joint Arthroplasty.

    Science.gov (United States)

    Bert, Jack M; Hooper, Jessica; Moen, Sam

    2017-12-01

    Outpatient total joint arthroplasty (OTJA) allows for a safe, cost effective pathway for appropriately selected patients. With current pressures on arthroplasty surgeons and their associated institutions to reduce costs per episode of care, it is important to define the steps and challenges associated with establishing an outpatient arthroplasty program. Several studies have outlined techniques of selecting patients suitable for this type of postoperative pathway. With emerging concerns about patients who undergo outpatient arthroplasty being at increased risk of medical complications, which may lessen projected cost savings, it is important to identify value-based strategies to optimize patient recovery after OTJA. This article reviews digital techniques for patient selection and data collection, operating room efficiency systems, and provides a summary of methods to build and maintain value in outpatient total joint replacement within the framework of bundled payment reimbursement.

  15. The Joint Cities

    Directory of Open Access Journals (Sweden)

    Romano Fistola

    2010-04-01

    Full Text Available The new connections, which high speed train allows to activate among the metropolitan systems, seem to be able to give life to new urban macro-structures for which the transfer time, among the main poles of the railway segment, becomes comparable to an inside moving into the city and therefore considered as an inter-functional mobility. The tunnel effect generated by the high speed connection seems to be able to allow a new temporal and functional joint among the metropolitan systems consequently supporting the possibility, for the users, to move themselves among the different urban functions belonging to the different cities. The birth of these urban aggregations seems to drive towards new megalopolis, which we can define for the first time with the term: joint-city. For this new metropolitan settlement it seems to be very interesting to investigate the constitutive peculiarities, the systemic articulation, its relational structures, the evolutionary scenarios, and so on. The urban functions (activities can be considered as structures of relationships between people that allows to define "organizational links" inside the community; the urban functions are located in specific places inside urban container or in open spaces. The urban functions represent the urban engines and the functional system can be thought as the “soul of the city", abstract but essential to its survival. In the definition set out here the analysis is carried out for many interconnected urban functional system points (specifically those in Rome and Naples. The new high speed railway has to be considered not only as a new channel of mobility between cities, but as a real possibility of joint between the functional systems of the two centres. A final consideration can be carried out in relation to the possibility of implementing new measures of governance of urban transformations considering the new macro-city: the "Joint City".

  16. Australias Joint Approach

    Science.gov (United States)

    2015-09-01

    Chapter 2. The most significant change is that the section on tools for the Needs Phase, mentioned earlier in this paper, has been deleted . In late...considering how they can be linked into common joint functions, runs the risk of becoming stuck in a replacement syndrome for capability development. 2...culture will be aided by the FPR’s implementation proposal to that Defence creates a culture where corporate behaviour is valued and rewarded. 313

  17. Joint Mission Command Implementation

    Science.gov (United States)

    2016-01-22

    1 AIR WAR COLLEGE AIR UNIVERSITY JOINT MISSION COMMAND IMPLEMENTATION by Michael Dane Acord, COL, US Army A Research Report Submitted to...assigned to the Air War College, Air University, Maxwell Air Force Base (AFB), AL. Following the Army Command and General Staff College and School...holds a Bachelor’s Degree in Biology and two Masters Degrees, a Masters in Management from Troy University and a Master of Military Arts and Sciences

  18. Redefining Murder: Joint Enterprise

    OpenAIRE

    Mitchell-Rodd, Nicola

    2013-01-01

    This article explores the evolution of secondary liability and the unforgiving doctrine of joint enterprise in homicide cases. Exploration of the current law ensues to determine if the distinct decisions of their Lordships in both Powell and Rahman have failed to sufficiently clarify the law; followed by in depth analysis of the Law Commission and Ministry of Justice proposals to reform this infamously disputed area of law.

  19. Prosthetic elbow joint

    Science.gov (United States)

    Weddendorf, Bruce C. (Inventor)

    1994-01-01

    An artificial, manually positionable elbow joint for use in an upper extremity, above-elbow, prosthetic is described. The prosthesis provides a locking feature that is easily controlled by the wearer. The instant elbow joint is very strong and durable enough to withstand the repeated heavy loadings encountered by a wearer who works in an industrial, construction, farming, or similar environment. The elbow joint of the present invention comprises a turntable, a frame, a forearm, and a locking assembly. The frame generally includes a housing for the locking assembly and two protruding ears. The forearm includes an elongated beam having a cup-shaped cylindrical member at one end and a locking wheel having a plurality of holes along a circular arc on its other end with a central bore for pivotal attachment to the protruding ears of the frame. The locking assembly includes a collar having a central opening with a plurality of internal grooves, a plurality of internal cam members each having a chamfered surface at one end and a V-shaped slot at its other end; an elongated locking pin having a crown wheel with cam surfaces and locking lugs secured thereto; two coiled compression springs; and a flexible filament attached to one end of the elongated locking pin and extending from the locking assembly for extending and retracting the locking pin into the holes in the locking wheel to permit selective adjustment of the forearm relative to the frame. In use, the turntable is affixed to the upper arm part of the prosthetic in the conventional manner, and the cup-shaped cylindrical member on one end of the forearm is affixed to the forearm piece of the prosthetic in the conventional manner. The elbow joint is easily adjusted and locked between maximum flex and extended positions.

  20. The international joint commission

    OpenAIRE

    Clamens, Murray

    2005-01-01

    For over 92 years the International Joint Commission (IJC), United States and Canada, has effectively served the two nations in approving and providing continuous oversight of water resource projects along the 5000-mile common border, in assisting the governments in preventing and resolving issues and disagreements regarding the use of these waters, and in addressing other environmental issues affecting or potentially affecting one or both of the countries. During the first years of the 20th...

  1. 2009 Joint CBRN Conference

    Science.gov (United States)

    2009-06-25

    Angeles, CA USC Rand Arroyo Center Tampa, FL University of South Florida Tempe, AZ ASU Research Park Austin, TX University of Texas Houghton, MI...Engagement 16 Maneuver Enhancement Brigade X A unique multi-functional unit to support Maneuver & Joint Forces commanders One of the five modular ...forward deployed CBRN detection capabilities • Key capabilities will focus on a modular approach – Analytical equipment – Analytical processes

  2. Optimized and practical electrical joints for CORC type HTS cables

    CERN Document Server

    Mulder, T; van der Laan, D C; Mentink, M G T; Dhallé, M; ten Kate, H H J

    2015-01-01

    Within CERN the development of REBCO-CORC (Conductor On Round Core) type cables is pursued in view of possible application in future detector and accelerator magnets. An important issue is the design and qualification of terminations for connecting CORC cables mutually or to bus-bars. A termination design is envisaged that combines a simple manufacturing process with a lowest possible joint terminal resistance in the few nΩ range at 4.2 K, first for a single CORC cable and subsequently for CORC based Cable-in-Conduit Conductors. The investigation concerns the effect of tapering the CORC cable within the joint to form a staircase like geometry, which allows current to pass more directly from the copper joint casing to the inner REBCO layers of the CORC cable. Simulations have shown a substantial decrease in joint resistance at operating current in the case both CORC cable and joint casing are tapered. The CORC cable and new joint were tested at CERN. In this paper, some details of the new joint design, fabric...

  3. Laboratory characterization of rock joints

    Energy Technology Data Exchange (ETDEWEB)

    Hsiung, S.M.; Kana, D.D.; Ahola, M.P.; Chowdhury, A.H.; Ghosh, A. [Southwest Research Inst., San Antonio, TX (United States). Center for Nuclear Waste Regulatory Analyses

    1994-05-01

    A laboratory characterization of the Apache Leap tuff joints under cyclic pseudostatic and dynamic loads has been undertaken to obtain a better understanding of dynamic joint shear behavior and to generate a complete data set that can be used for validation of existing rock-joint models. Study has indicated that available methods for determining joint roughness coefficient (JRC) significantly underestimate the roughness coefficient of the Apache Leap tuff joints, that will lead to an underestimation of the joint shear strength. The results of the direct shear tests have indicated that both under cyclic pseudostatic and dynamic loadings the joint resistance upon reverse shearing is smaller than that of forward shearing and the joint dilation resulting from forward shearing recovers during reverse shearing. Within the range of variation of shearing velocity used in these tests, the shearing velocity effect on rock-joint behavior seems to be minor, and no noticeable effect on the peak joint shear strength and the joint shear strength for the reverse shearing is observed.

  4. Does generalized joint hypermobility predict joint injury in sport? A review.

    LENUS (Irish Health Repository)

    Donaldson, Peter R

    2012-02-01

    OBJECTIVE: To determine whether persons with generalized joint hypermobility have an increased risk of lower limb joint injury during sport. DATA SOURCES: PubMed, CINAHL, EMBASE, and SportDiscus were searched through February 2009, without language restrictions, using terms related to risk; hip, ankle, and knee injuries; and joint instability. Reference lists of included studies and relevant reviews were searched by hand. STUDY SELECTION: Selection criteria were peer-reviewed studies with a prospective design that used an objective scale to measure generalized joint hypermobility; the participants were engaged in sport activity, and the injury data were quantitative and based on diagnosis by a health professional, were self-reported, or resulted in time lost to athletic participation. The studies were screened by 1 researcher and checked by a second. Study methods were independently assessed by 2 investigators using the 6-point scale for prognostic studies developed by Pengel. Disagreements were resolved through discussion. Of 4841 studies identified, 18 met inclusion criteria. Of these, 8 were included in random-effects meta-analyses. DATA EXTRACTION: The data extracted by 2 reviewers included participant and sport characteristics and details of joint hypermobility and injury measurements. More detailed data for 4 investigations were obtained from the study authors. Where possible, hypermobility was defined as >\\/=4 of 9 points on the British Society of Rheumatology Scale (BSRS). MAIN RESULTS: Lower limb joint injuries (3 studies, 1047 participants) occurred in 14% of participants. Using the BSRS of joint hypermobility, any lower limb injury was not associated with hypermobility [odds ratio (OR), 1.43; 95% confidence interval (CI), 0.56-3.67]. Using the original authors\\' definitions, hypermobility was associated with risk of knee joint injuries (OR, 2.62; 95% CI, 1.04-6.58) in 5 studies. In 4 studies in which the BSRS could be used (1167 participants; incidence

  5. Timber joints under long-term loading

    DEFF Research Database (Denmark)

    Feldborg, T.; Johansen, M.

    This report describes tests and results from stiffness and strength testing of splice joints under long-term loading. During two years of loading the spicimens were exposed to cyclically changing relative humidity. After the loading period the specimens were short-term tested. The connectors were...... integral nail-plates and nailed steel and plywood gussets. The report is intended for designers and researchers in timber engineering....

  6. Shaping ability of Reciproc and TF Adaptive systems in severely curved canals of rapid microCT-based prototyping molar replicas

    Directory of Open Access Journals (Sweden)

    Ronald ORDINOLA-ZAPATA

    2014-12-01

    Full Text Available Objective: To evaluate the shaping ability of Reciproc and Twisted-File Adaptive systems in rapid prototyping replicas. Material and Methods: Two mandibular molars showing S-shaped and 62-degree curvatures in the mesial root were scanned by using a microcomputed tomography (μCT system. The data were exported in the stereolitograhic format and 20 samples of each molar were printed at 16 µm resolution. The mesial canals of 10 replicas of each specimen were prepared with each system. Transportation was measured by overlapping radiographs taken before and after preparation and resin thickness after instrumentation was measured by μCT. Results: Both systems maintained the original shape of the apical third in both anatomies (P>0.05. Overall, considering the resin thickness in the 62-degree replicas, no statistical difference was found between the systems (P>0.05. In the S-shaped curvature replica, Reciproc significantly decreased the thickness of the resin walls in comparison with TF Adaptive. Conclusions: The evaluated systems were able to maintain the original shape at the apical third of severely curved mesial canals of molar replicas.

  7. Signatures of new d-wave vortex physics in overdoped Tl2Ba2CuO(6+x) revealed by TF-µ(+)SR.

    Science.gov (United States)

    Brewer, Jess H; Stubbs, Scott L; Liang, Ruixing; Bonn, D A; Hardy, W N; Sonier, J E; MacFarlane, W Andrew; Peets, Darren C

    2015-09-16

    The spontaneous expulsion of applied magnetic field, the Meissner effect, is a defining feature of superconductors; in Type-II superconductors above the lower critical field, this screening takes the form of a lattice of magnetic flux vortices. Using implanted spin-1/2 positive muons, one can measure the vortex lattice field distribution through the spin precession and deduce key parameters of the superconducting ground state, and thereby fundamental properties of the superconducting pairing. Muon spin rotation/relaxation (µSR) experiments have indeed revealed much interesting physics in the underdoped cuprates, where superconductivity is closely related to, or coexistent with, disordered or fluctuating magnetic and charge excitations. Such complications should be absent in overdoped cuprates, which are believed to exhibit conventional Fermi liquid behaviour. These first transverse field (TF)-µ(+)SR experiments on heavily-overdoped single crystals reveal a superfluid density exhibiting a clear inflection point near 0.5Tc, with a striking doping-independent scaling. This reflects hitherto unrecognized physics intrinsic to d-wave vortices, evidently generic to the cuprates, and may offer fundamentally new insights into their still-mysterious superconductivity.

  8. Synthetic Versus Tissue-Engineered Implants for Joint Replacement

    Directory of Open Access Journals (Sweden)

    Duncan E. T. Shepherd

    2007-01-01

    Full Text Available Human synovial joints are remarkable as they can last for a lifetime. However, they can be affected by disease that may lead to destruction of the joint surface. The most common treatment in the advanced stages of joint disease is artificial joint replacement, where the diseased synovial joint is replaced with an artificial implant made from synthetic materials, such as metals and polymers. A new technique for repairing diseased synovial joints is tissue engineering where cells are used to grow replacement tissue. This paper explores the relative merits of synthetic and tissue-engineered implants, using joint replacement as an example. Synthetic joint replacement is a well-established procedure with the advantages of early mobilisation, pain relief and high patient satisfaction. However, synthetic implants are not natural tissues; they can cause adverse reactions to the body and there could be a mismatch in mechanical properties compared to natural tissues. Tissue-engineered implants offer great potential and have major advantages over synthetic implants as they are natural tissue, which should ensure that they are totally biocompatible, have the correct mechanical properties and integrate well with the existing tissue. However, there are still many limitations to be addressed in tissue engineering such as scaling up for production, bioreactor design, appropriate regulation and the potential for disease to attack the new tissue-engineered implant.

  9. Majorana Demonstrator Bolted Joint Mechanical and Thermal Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Aguayo Navarrete, Estanislao; Reid, Douglas J.; Fast, James E.

    2012-06-01

    The MAJORANA DEMONSTRATOR is designed to probe for neutrinoless double-beta decay, an extremely rare process with a half-life in the order of 1026 years. The experiment uses an ultra-low background, high-purity germanium detector array. The germanium crystals are both the source and the detector in this experiment. Operating these crystals as ionizing radiation detectors requires having them under cryogenic conditions (below 90 K). A liquid nitrogen thermosyphon is used to extract the heat from the detectors. The detector channels are arranged in strings and thermally coupled to the thermosyphon through a cold plate. The cold plate is joined to the thermosyphon by a bolted joint. This circular plate is housed inside the cryostat can. This document provides a detailed study of the bolted joint that connects the cold plate and the thermosyphon. An analysis of the mechanical and thermal properties of this bolted joint is presented. The force applied to the joint is derived from the torque applied to each one of the six bolts that form the joint. The thermal conductivity of the joint is measured as a function of applied force. The required heat conductivity for a successful experiment is the combination of the thermal conductivity of the detector string and this joint. The thermal behavior of the joint is experimentally implemented and analyzed in this study.

  10. Joint-sparing Corrections in Malunited Lisfranc Joint Injuries.

    Science.gov (United States)

    Nery, Caio; Raduan, Fernando; Baumfeld, Daniel

    2016-03-01

    Lisfranc fracture-dislocations are very serious and potentially disabling injuries. Unfortunately, they are often misdiagnosed. Multiplanar midfoot deformities that result from these fracture-dislocations are precursors of joint degeneration and significant functional disabilities. Anatomic reduction with different types of internal fixation is an efficient method to reconstruct midfoot alignment and stability. Joint-preserving reconstruction techniques emerge as a viable alternative to corrective fusion as they achieve stable joint realignment with preserved motion. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Space Suit Joint Torque Measurement Method Validation

    Science.gov (United States)

    Valish, Dana; Eversley, Karina

    2012-01-01

    In 2009 and early 2010, a test method was developed and performed to quantify the torque required to manipulate joints in several existing operational and prototype space suits. This was done in an effort to develop joint torque requirements appropriate for a new Constellation Program space suit system. The same test method was levied on the Constellation space suit contractors to verify that their suit design met the requirements. However, because the original test was set up and conducted by a single test operator there was some question as to whether this method was repeatable enough to be considered a standard verification method for Constellation or other future development programs. In order to validate the method itself, a representative subset of the previous test was repeated, using the same information that would be available to space suit contractors, but set up and conducted by someone not familiar with the previous test. The resultant data was compared using graphical and statistical analysis; the results indicated a significant variance in values reported for a subset of the re-tested joints. Potential variables that could have affected the data were identified and a third round of testing was conducted in an attempt to eliminate and/or quantify the effects of these variables. The results of the third test effort will be used to determine whether or not the proposed joint torque methodology can be applied to future space suit development contracts.

  12. Joint Advisory Appeals Board

    CERN Multimedia

    2003-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Aloïs Girardoz with regard to classification and advancement. As the appellant has not objected, the Board's report and the Director-General's decision will be brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 15 to 29 August 2003. Human Resources Division Tel. 74128

  13. Joint Advisory Appeals Board

    CERN Multimedia

    2003-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Poul Frandsen concerning his assimilation into the new career structure. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 13 to 24 January 2003. Human Resources Division Tel. 74128

  14. Temporomandibular Joint Imaging.

    Science.gov (United States)

    Tamimi, Dania; Jalali, Elnaz; Hatcher, David

    2018-01-01

    The temporomandibular joint (TMJ) is an anatomically and biomechanically complex structure. Understanding how this structure grows and functions is essential to accurate radiographic evaluation. This article discusses the anatomy, function, and growth and development of the TMJ and how growth changes can affect the morphology of the craniofacial structures. Accordingly, the radiographic appearance of the entities that may alter the TMJ are discussed, including developmental, degenerative, inflammatory, and traumatic changes. Both osseous imaging and soft tissue imaging are shown. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Gert Jan Bossen with regard to dependent child allowance. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 1st to 15 March 2002. Human Resources Division Tel. 74128

  16. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2006-01-01

    The Joint Advisory Appeals Board was convened to examine an appeal lodged by a member of the personnel with regard to advancement. The person concerned has requested that the report of the Board and the final decision of the Director-General be brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (No. 60) from 24 March to 10 April 2006. Human Resources Department Tel. 74128

  17. Joint Advisory Appeals Board

    CERN Multimedia

    2013-01-01

    The Joint Advisory Appeals Board has examined the internal appeal lodged by a former member of the personnel, a beneficiary of the CERN Pension Fund, against the calculation of his pension in the framework of the Progressive Retirement Programme.   The person concerned has not objected to the report of the Board and the final decision of the Director-General being brought to the attention of the members of the personnel. In application of Article R VI 1.18 of the Staff Regulations, these documents will therefore be available from 26 July to 11 August 2013 at the following link. HR Department Head Office

  18. [Temporomandibular joint disc surgery].

    Science.gov (United States)

    Potier, J; Maes, J-M; Nicot, R; Dumousseau, T; Cotelle, M; Ferri, J

    2016-09-01

    Temporomandibular joint (TMJ) disorders are a common disease and may be responsible for major functional and painful repercussions. Treatment is not consensual. The literature highlights the role of conservative treatments (physiotherapy, analgesics, splints) in a first attempt. Minimally invasive surgical techniques (arthroscopy, arthrocentesis) have developed rapidly in recent decades. They have proven effective and reliable, especially in patients suffering from irreducible or reducible anterior disc dislocation or presenting with arthopathies. The goal of our work was to make an update about disk surgery. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  19. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2007-01-01

    The Joint Advisory Appeals Board was convened to examine an internal appeal lodged by a member of the personnel with regard to the decision not to grant him an indefinite contract. The person concerned has requested that the report of the Board and the final decision of the Director-General be brought to the notice of the members of the personnel, in accordance with Article R VI 1.18 of the Staff Regulations. The relevant documents will therefore be posted on the notice board of the Main building (Bldg. 60) from 24 September to 7 October 2007. Human Resources Department

  20. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Personnel Division

    1999-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Joào Bento with regard to residential category. As the appellant has not objected, the recommendations of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article RÊVIÊ1.20 of the Staff Regulations.The relevant documents will therefore be posted on the notice boards of the Administration Building (N¡ 60) from 29 October to 12 November 1999.Personnel DivisionTel. 74128