WorldWideScience

Sample records for testi autor andres

  1. Peapiiskop Andres Põderi jutlus / Andres Põder

    Index Scriptorium Estoniae

    Põder, Andres, 1949-

    2005-01-01

    Peapiiskop Andres Põderi jutlus oma ametissepühitsemise jumalateenistusel 2. veebruaril. Ilmunud ka: Põder, Andres. Pärimuste pöördepunkt : kõned ja kirjutised. - Tallinn : Kunst, 2007, 107-112

  2. Põlvas tuli esitusele Andre Laine 29 tantsu / Mati Määrits

    Index Scriptorium Estoniae

    Määrits, Mati, 1958-

    2008-01-01

    Põlva Kultuuri- ja Huvikeskuses sai näha Põlvamaa Koolitantsu maakondlikku eelvooru. 52st tantsust 29 tantsu autor on Andre Laine. Kommenteerib ka Tartu Ülikooli Viljandi Kultuuriakadeemia lavakunstide osakonna tantsukunsti õppejõud Kai Valtna

  3. Instrucciones a los Autores

    Directory of Open Access Journals (Sweden)

    revistaiid@ uptc.edu.co

    2006-12-01

    Full Text Available Ingeniería,  Investigación y Desarrollo publica  trabajos inéditos sobre geología, minería, electrónica, industrial y ciencias afines, en español. Podrán publicarse artículos originales, de investigación y/o innovación tecnológica, de revisión o réplicas de publicaciones de la propia revista. Además, se podrán incluir  resúmenes de  tesis,  reseñas de  libros y comunicaciones de  interés a estas profesiones.Para  la presentación de  los artículos  se debe  tener en cuenta que: Los artículos serán evaluados por   el comité Editorial y un árbitro, el que se reserva el derecho de decidir sobre su publicación. Los  trabajos enviados a  Ingeniería,  Investigación y Desarrollo, no podrán ser sometidos simultáneamente a evaluación por otro medio de publicación. El contenido de los trabajos   es responsabilidad exclusiva de sus autores. No se devolverán los originales de los trabajos

  4. Undescended testis

    DEFF Research Database (Denmark)

    Hutson, John M.; Vikraman, Jaya; Li, Ruili

    2017-01-01

    controlled by androgens. The latter phase requires a complex process of migration from the inguinal abdominal wall to the scrotum and is commonly defective, leading to the high incidence (2–4%) of UDT at birth. The clinical examination of babies and infants aims to confirm the persistence of congenital UDT......Undescended testis (UDT) occurs when something goes wrong with testicular descent from high in the abdominal cavity to the scrotum. Normal descent occurs in two steps, with the transabdominal phase controlled by a new testicular hormone, insulin-like hormone 3, and the inguinoscrotal phase...... by 3–6 months, so surgery can be optimally timed at 6–12 months. For those boys who develop acquired UDT later in childhood, the ‘ascending’ testis often needs surgery between 5 years and 10 years, so all boys should be screened again for UDT at school entry....

  5. Indicaciones a los Autores

    Directory of Open Access Journals (Sweden)

    Academia Nacional de Medicina

    1985-04-01

    Full Text Available

    1. La revista MEDICINA, órgano oficial de la Academia Nacional de Medicina, de Colombia, publica artículos de toda especialidad previa aprobación del Comité Editorial.

    2. Los trabajos deben ser inéditos y suministrados a la revista. Su reproducción total o parcial debe contar con la aprobación del editor y dar crédito a la publicación original.

    3. Los trabajos deben ser entregados a la Revista, Calle 60A No. 5-29, sede de la Academia, Bogotá, Colombia, en originales escritos a máquina en papel blanco tamaño carta empleando una sola cara del papel, con tinta negra y a doble espacio, guardando un margen izquierdo de 4 cm.

    4. Cada componente del trabajo debe iniciarse en una nueva página de acuerdo con la siguiente secuencia: página del título, resumen y palabras claves, texto, resumen en inglés (summary si es el caso, agradecimientos, bibliografía, tablas (cada tabla en página separada con su título y notas y leyendas para las figuras.

    5. En la primera página se incluye el título, corto y que refleje el contenido del artículo, el nombre del autor y sus colaboradores con los respectivos títulos académicos y el nombre de la institución a la cual pertenecen.

    6. El resumen, de no más de 150 palabras, debe enunciar los propósitos del estudio o de la investigación, los procedimientos básicos, los hallazgos principales y las conclusiones. A continuación del resumen deben suministrarse entre 3 y 10 palabras claves o frases cortas que servirán para elaborar el índice anual de materias.

    7. El texto debe incluir introducción, material y métodos, resultados y discusión: las abreviaturas deben explicarse y su uso limitarse.

    8. El resumen en inglés (summary, debe contener los mismos puntos del resumen original.

    9. La bibliografía se numera de acuerdo con el orden de aparición de las citas en el texto y se escriben a doble espacio....

  6. Andres Ehin Jaapanist Iirini

    Index Scriptorium Estoniae

    2006-01-01

    Andres Ehin valiti Ülemaailmse Haiku Assotsiatsiooni auliikmeks ja kirjaniku inglisekeelset luulekogu "Moose Beetle Swallow" esitleti 2005. aasta Euroopa kultuuripealinnas Corkis Iirimaal. Järgneb: Looming 2006, nr. 2, lk. 311

  7. Andres Puustusmaa esikfilm Moskva filmifestivalil / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Eestist pärit režissööril Andres Puustusmaal esilinastub 29. juunil Moskva filmifestivali raames tema esimene täispikk mängufilm, Venemaa ja Ukraina ühistöö "Armastuse punane pärl" ("Krasnõi zhemtshug ljubvi"), peaosas Oksana Fandera, operaatoriks soomlane Timo Salminen. Valmis on ka teine mängufilm "1814", mis koos eespool nimetatuga tuleb kinodesse septembris. Ka Moskva festivali kavast

  8. Retrofuturistlik tulevik / Andres Lõo

    Index Scriptorium Estoniae

    Lõo, Andres, 1978-

    2012-01-01

    17. septembril NO99 teatris esietendunud kolme teatri - NO99, Münchner Kammerspiele, Lyric Hammersmith Theatre - koostöös valminud lavastusest "Three Kingdoms" ("Kolm kuningriiki"), teksti autor Simon Stephens, lavastaja Sebastian Nübling

  9. Kohtumine Oslos / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2009-01-01

    Autor kommenteerib Oslos toimunud Tšetšeenia eksiilvalitsuse juhi Ahmed Zakajevi ning praeguse Tšetšeenia valitseja Ramzan Kadõrovi esindaja ja parlamendijuhi Duhhvahha Abdurahmanovi kohtumist. Versioonid tulevikuks

  10. Graafikatriennaali peapreemia Andres Talile

    Index Scriptorium Estoniae

    2001-01-01

    Tallinna XII graafikatriennaali preemiad: grand prix - Andres Tali; 3 võrdset preemiat - Janne Laine, Leonards Laganovskis, Peeter Laurits; diplomid - Lynne Allen, Lucrecia Urbano, Vladimir Tshaika, Zora Stanè, Endi Poskovic, Päivikki Kallio; EKM preemia - Tif Bitmap; Tallinna linna preemia - Ülle Marks ja Jüri Kass; eripreemiad: - J. Laine (Eesti Pank), Vive Tolli (Paletti Eesti AS), Martins Ratniksh, Juris Boiko, T. Bitmap (Balteco AS). Žürii koosseis

  11. Maramaa elust poksi ja graffitini / Andres Lepik, Ott Aardam ; interv. Gert Kiiler

    Index Scriptorium Estoniae

    Lepik, Andres

    2008-01-01

    Ugala teater alustas 89. hooaega. Esimese poole plaanitud esietendused : Toomas Suumani "Linnapea" Heiki Raudla raamatu "August Maramaa aeg" järgi, lavastaja Andres Lepik. Ott Aardami noortetükist "Poks", lavastaja autor. Gerald Sibleyras' "Grafiti", lavastaja Taago Tubin. Silvia Soro jõulunäidend "Inetu pardipoja" ainetel, lavastaja Oleg Titov

  12. Estonian Golf Countri Club'i Jägala golfiklubi sisekujundus. Jõelähtme, Mannila küla / Juta Lember, Andres Siim, Tarmo Luisk...[jt.

    Index Scriptorium Estoniae

    2006-01-01

    3 korruste plaani, värv. välisvaade, 22 sisevaadet; fotod: Kalle Veesaar; Juta Lember projekteeris ka tammepuust mööbli; arhitekt Andres Siim; nõupidamisruumi toolide ja nagide autor: Toivo Raidmets; metallvalgustite autor: Tarmo Luisk

  13. Andres Rõhu: kujundaja metsast / Andres Rõhu ; intervjueerinud Kaarel Kressa

    Index Scriptorium Estoniae

    Rõhu, Andres, 1965-

    2010-01-01

    Maalikunstnik Andres Rõhu sellest, kuidas temast sai raamatute kujundaja, parematest enda kujundatud raamatutest, südamelähedasematest eesti raamatukujundajatest, maal elamise eelistest. Loetletud A, Rõhu kujundatud teoseid

  14. Maailmaparandajad / Ole Ry, Susanne Andres

    Index Scriptorium Estoniae

    Ry, Ole

    2012-01-01

    Terapeudid Ole Ry ja Susanne Andres räägivad Dr David Berceli loodud TRE (Tension & Trauma Releasing Exercises) harjutuste kasutamise kogemusest erinevate psüühiliste traumade ja pingetega klientide tervise parandamisel

  15. Los derechos de autor sobre obtenciones vegetales

    Directory of Open Access Journals (Sweden)

    Rosario Silva Gilli

    2015-01-01

    Full Text Available Contenido: Las creaciones en la agricultura. Los derechos de autor sobre obtenciones vegetales. El Convenio Internacional para la protección de las obtenciones vegetales (París 1961 y sus revisiones de Ginebra 1972, 1978,1991 Objeto de la protección legal. Condiciones del cultivar. Alcance de la protección. La protección de obtenciones vegetales en el Mercosur. Los Derechos de autor en el Mercosur. El Protocolo de Armonización de normas sobre Propiedad Intelectual en el Mercosur. El Acuerdo de Cooperación y facilitación sobre la protección de las obtenciones vegetales en los Estados Partes del Mercosur.  Alcance de la normativa Mercosur. Los Derechos sobre cultivares en Uruguay. Los Derechos de autor como derechos humanos. ¿Derechos de autor vs. derecho de propiedad intelectual? Reflexión final

  16. Building the mammalian testis

    DEFF Research Database (Denmark)

    Svingen, Terje; Koopman, Peter

    2013-01-01

    Development of testes in the mammalian embryo requires the formation and assembly of several cell types that allow these organs to achieve their roles in male reproduction and endocrine regulation. Testis development is unusual in that several cell types such as Sertoli, Leydig, and spermatogonial...

  17. Mis juhtus Andres Lapeteusega? : error'ist kõrgklassi homo soveticus'e näitel / Liisa Kaljula

    Index Scriptorium Estoniae

    Kaljula, Liisa, 1982-

    2014-01-01

    Autor analüüsib 2014. a. Tallinna Semiosalongi loengute sarja põhiteema - error'i mõiste avamiseks ühe inimliigi kujunemislugu - Eesti filmiklassikast tuntud tegelaskuju Andres Lapeteuse tõusu ning langust homo soveticus'ena

  18. Perfiles de autor en repositorios institucionales

    Directory of Open Access Journals (Sweden)

    Patricia Genovés

    2017-10-01

    Full Text Available Este trabajo describe las funciones y utilidades de la implementación de perfiles de autor en repositorios institucionales, como un servicio de valor agregado dirigido a acrecentar su uso entre los miembros de una institución y mejorar la visibilidad de la producción científica alojada en el repositorio. Incluye un relevamiento de servicios de perfiles de autor implementados en repositorios institucionales argentinos y extranjeros. Advierte que, ante el establecimiento de mandatos nacionales de depósito, la necesidad de contar con repositorios institucionales fuertes y sostenibles en el tiempo es aún mayor que antes. Integrar a los repositorios las funcionalidades de los sistemas curriculares y de gestión de información científica y tecnológica es un camino para lograr esa fortaleza, y los perfiles de autor son el resultado visible de dicha integración. Señala que el beneficio que representa para un autor contar con un perfil público en el repositorio de su institución es equivalente al beneficio que para una institución representa contar con un repositorio digital, en términos de ventaja competitiva, valor añadido, incremento de la visibilidad y facilidades de recuperación y acceso a la producción generada.

  19. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  20. Los derechos de autor en internet

    Directory of Open Access Journals (Sweden)

    Marcelo Bauzá

    2014-10-01

    Full Text Available Contenido: Un punto de partida: prudencia e interrogantes. La propiedad intelectual y su constante readaptación. El derecho autoral en breves trazos. La conmoción de internet. Tipología de obras autorales en el nuevo contexto. Problemas autorales relacionados con internet. Las protecciones técnicas. Propiedad intelectual y comercio electrónico. Regulaciones jurídicas incipientes. Las disidencias o alternativas a la P.I. en internet. Reflexiones finales

  1. GUÍAS PARA LOS AUTORES

    Directory of Open Access Journals (Sweden)

    INGRID TORRES

    2012-12-01

    Full Text Available Los autores que deseen enviar sus publicaciones a la revista Lámpsakos deberán ceñirse a las instrucciones mínimas de formato del manuscrito, y concordar con las condiciones éticas requeridas en las publicaciones. Se proporciona información en los idiomas español e inglés

  2. El derecho del autor asalariado en Argentina

    Directory of Open Access Journals (Sweden)

    Augusto H. L. Arduino

    2013-11-01

    Full Text Available El autor contratado bajo relación de dependencia laboral en la Argentina no se encuentra regulado en la legislación sobre derecho de autor. La ley número 11723 no contempla la figura, y la reforma de la ley número 25.036 en su art. 2 solo hace referencia a los programas de computación realizados en virtud de un contrato laboral. No obstante, la ley de patentes número 24481 modificada por ley número 24572, ha regulado la cuestión de los derechos de explotación de patentes de invención, mediando relación contractual. Asimismo se ha regulado en ley número 20.744 lo relativo a las invenciones del trabajador. En la ley de patentes de invención se regula la situación del inventor contratado o asalariado. El derecho laboral y la propiedad intelectual en general, y en particular el derecho de autor son de naturaleza diversa y tienen regulaciones específicas con principios jurídicos propios. Por ello, se abordará cada temática desde su generalidad a fin de arribar al tratamiento del problema planteado.

  3. Suursaadik Andres Talvik : Prantsusmaa ei ole euroliidu laienemise pooldaja / Andres Talvik ; interv. Marianne Mikko

    Index Scriptorium Estoniae

    Talvik, Andres, 1947-

    2002-01-01

    Eesti suursaadik Prantsusmaal Andres Talvik Prantsusmaa presidendivalimistest, paremäärmuslase Jean-Marie Le Peni pääsemisest selle II vooru, prantslaste vastuseisust EL-i laienemisele, Prantsuse-Saksa suhetest. Andres Talviku elulooandmeid

  4. Dibujos que hablan : El ilustrador como autor

    OpenAIRE

    Isol

    2011-01-01

    El dibujante en el libro ilustrado tiene el mismo poder que el director en el teatro. Elige el escenario, los personajes, la mirada que va a tener sobre ese "cuento” que se cuenta. Por eso el ilustrador es también un autor, y sus elecciones crean sentido narrativo. Esto que es tan usual en teatro y cine, todavía es difícil de asumir para algunos ilustradores y editores: el valor de la imagen en los libros, y su poder narrativo. De hecho, hace diez años en Argentina, el ilustrador no cobraba d...

  5. Coexistencia del autor medieval y el autor contemporáneo en Aura

    Directory of Open Access Journals (Sweden)

    Maite Pizarro Granada

    2017-11-01

    Full Text Available Este artículo plantea para la novela Aura, una entrada de lectura según la cual el lector se transforma en protagonista, encarna la esencia marginal del autor medieval y al mismo tiempo muestra su evolución para transformarse en el autor contemporáneo. El objetivo es plantear una reflexión sobre la evolución que ha experimentado la noción de autoría a lo largo de la historia y mostrar cómo en la novela, la memoria actual (representada por la figura del historiador se apropia de la realidad a través de la concreción de la fantasía y de las invenciones o cambios sujetos al proceso de remembranza. Interesa, en última instancia, mostrar que recordar el pasado supone un ejercicio creativo en el que, el historiador también se comporta como autor en la medida en que ofrece una nueva perspectiva anclada en el presente.

  6. Vabadus teeb rikkaks / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2005-01-01

    Autor analüüsib Eesti majandusvabadust kahe edetabelipõhjal: ühte koostab alates 1996. aastast Kanadas asuv Frazeri Instituut, teist USA-s asuv Heritage Foundation ja majandusajakiri The Wall Street Journal. Diagramm: Majandusvabaduse indeksi muutus mullu Euroopa Liidus

  7. Europan 7 Eestis : Lasnamäe. Pärnu / Tiit Trummal, Andres Kurg

    Index Scriptorium Estoniae

    Trummal, Tiit, 1954-

    2004-01-01

    Võistluse "Äärelinna võimalus, linnalik intensiivsus ja elamise mitmekesisus" Eesti-Rootsi ühisžüriis Eestist Urmas Muru, Tiit Trummal, Andres Kurg. Tallinna Lasnamäe (14 tööd) ja Pärnu (47 tööd) võistlusalast, võitnud tööde arhitektide loetelu ja võitnud töödest. Lasnamäe: I preemia - autor hispaanlane Andres Fernandes Atela, kaasautorid prantslased Mathieu Andrieu ja Iman Morshedi. Pärnu: I preemia - autorid rumeenlane Oana-Maria Bogdan, ameeriklane Susan Kelly Shannon, argentiinlane Laura Vescina, hispaanlased Juny Llach ja Parra Colacios

  8. Hanging drop cultures of human testis and testis cancer samples

    DEFF Research Database (Denmark)

    Jørgensen, Anne; Young, J; Nielsen, J E

    2014-01-01

    cultured in 'hanging drops' and effects of activin A and follistatin treatment were investigated in seminoma cultures. RESULTS: Testis fragments with normal spermatogenesis or CIS cells were cultured for 14 days with sustained proliferation of germ cells and CIS cells and without increased apoptosis....... Seminoma cultures survived 7 days, with proliferating cells detectable during the first 5 days. Activin A treatment significantly reduced KIT transcript and protein levels in seminoma cultures, thereby demonstrating a specific treatment response. CONCLUSIONS: Hanging drop cultures of human testis...

  9. Oncogenic cancer/testis antigens

    DEFF Research Database (Denmark)

    Gjerstorff, Morten F; Andersen, Mads H; Ditzel, Henrik J

    2015-01-01

    Recent developments have set the stage for immunotherapy as a supplement to conventional cancer treatment. Consequently, a significant effort is required to further improve efficacy and specificity, particularly the identification of optimal therapeutic targets for clinical testing. Cancer....../testis antigens are immunogenic, highly cancer-specific, and frequently expressed in various types of cancer, which make them promising candidate targets for cancer immunotherapy, including cancer vaccination and adoptive T-cell transfer with chimeric T-cell receptors. Our current understanding of tumor...... immunology and immune escape suggests that targeting oncogenic antigens may be beneficial, meaning that identification of cancer/testis antigens with oncogenic properties is of high priority. Recent work from our lab and others provide evidence that many cancer/testis antigens, in fact, have oncogenic...

  10. Vulkaner andre steder i Solsystemet

    DEFF Research Database (Denmark)

    Haack, Henning

    2007-01-01

    Jupiters måne, Io, og man regner man med at Venus og formentlig også Mars stadig er vulkansk aktive. Ved at rette blikket ud i solsystemet har vi  mulighed for at studere vulkansk aktivitet under helt anderledes betingelser end her på Jorden. Hvad sker der f.eks., hvis tyngdekraften er svagere, eller...... planetens overflade måske er gloende varm? Vulkanerne andre steder i Solsystemet overgår på mange måder dem på Jorden. Venus er den planet i solsystemet, der har flest vulkaner, Mars har de største og højeste vulkaner, asteroiden Vesta har de ældste, og Jupiters måne Io har de mest aktive vulkaner i...

  11. Testis. Strategy for the management of seminoma testis

    International Nuclear Information System (INIS)

    Fetterly, J.C.M.

    1984-01-01

    Many years of experience demonstrate the marked radiocurability of seminoma testis with modest radiation dosage, and accordingly large volumes may be radiated without damage to surrounding normal structures. While several histological types of seminoma are described (classical, anaplastic, or spermatocytic) our treatment strategy is identical

  12. Harju Elekter väärtustab strateegilist partnerlust / Andres Aarma

    Index Scriptorium Estoniae

    Aarma, Andres

    2003-01-01

    Autor kirjeldab elektriseadmete ja -materjalide tootja, ettevõtte Harju Elekter edu põhjuseid läbi olulisemate strateegiliste juhtimisotsuste, personalijuhtimise, tootmise ning toodangu turustamise. Kommenteerivad Sander Danil, Jako Kotkas, Andres Vainola, Rein Siim ja Triin Palge. Diagrammid: Harju Elektri käive, eksport ja kasum, turud käibe järgi, tegevusalad käibe järgi. Skeemid: Harju Elektri tütar- ja sidusettevõtted, organisatsiooni struktuur. Vt. samas intervjuud Harju Elektri nõukogu esimehe Endel Pallaga; Harju Elektri kontsern täna. Lisad: Harju Elektri olulisemad koostöölepingud, laenude tagatised ja panditud vara

  13. Cafe Lyon = Cafe Lyon / Andres Labi

    Index Scriptorium Estoniae

    Labi, Andres, 1977-

    2013-01-01

    Cafe Lyon (Meistri 22, Tallinn) sisekujundusest. Autorid: Janno Roos, Andres Labi, Kristel Jakobson (Ruumilabor). Prantsuse Lütseumi direktori Lauri Leesi arvamus. Disainibüroo Ruumilabor lühitutvustus

  14. Risk factors for undescended testis.

    NARCIS (Netherlands)

    Brouwers, M.M.; Bruijne, L.M. de; Gier, R.P.E. de; Zielhuis, G.A.; Feitz, W.F.J.; Roeleveld, N.

    2012-01-01

    OBJECTIVE: To contribute to the understanding of the etiology of undescended testis (UDT), by exploring a wide range of potential risk factors in a case-referent study. PATIENTS AND METHODS: Cases and referents were recruited at five hospitals and included 200 boys with surgically corrected UDT and

  15. Andres Noormets - olemuselt luuletaja, vormilt lavastaja / Andres Noormets ; intervjueerinud Tiiu Laks

    Index Scriptorium Estoniae

    Noormets, Andres, 1963-

    2010-01-01

    Andres Noormets endast, oma lavastustest, näitlemisest ja lavastamisest, elu mõttest, uue otsimisest oma teatritöödega, sellest, mis endiselt paelub teatris ja praegusi teatritegemisi enim mõjutab, ise kirjutamisest jm. Andres Noormetsa eluloolisi andmeid

  16. Andres Ellamaa : suurperede seostamine asotsiaalsusega mõjub koletislikult / Andres Ellamaa ; interv. Indrek Veiserik

    Index Scriptorium Estoniae

    Ellamaa, Andres, 1944-

    2008-01-01

    Vestlus doktor Andres Ellamaaga suurperede toetamisest, kunstlikust viljastamisest. Lisaks: Kuidas kommenteerite dr. Andres Ellamaa 2. juuni Postimehes ilmunud artikli järel tekkinud diskussiooni avalikkuses ja meedias? Kommenteerivad Tallinna Arstide Liidu juhatuse liige Peeter Mardna ja Jõgeva haigla juhataja Peep Põdder

  17. Effectiveness of testis cancer screening

    International Nuclear Information System (INIS)

    Feucht, H.

    1983-04-01

    In the Federal Republic of Germany there are about thousand to two-thousand incidences of testis cancer yearly. The screening (and examination) program currently used for the early detection of cancer includes the screening of malignant tumours of the testis. Since only males 45 years and older are invited to make use of the preventive measures, the most seriously affected age-group between twenty and forty is hereby not considered. The objective of this study is to find out which of the generally conceivable preventive measures could lead to an improvement of the present situation. The analysis shows that, for a diagnostic accuracy of 1 and a participation of 100%, the quantifyable cost of a yearly performed special screening is higher than the quantifyable cost savings achieved. A final judgement of other ways of execution is only possible when the diagnostic accuracy of suitable screening methods and the percentage of the participants of the groups of people concerned are known. (orig.)

  18. PT symmetric Aubry–Andre model

    International Nuclear Information System (INIS)

    Yuce, C.

    2014-01-01

    PT symmetric Aubry–Andre model describes an array of N coupled optical waveguides with position-dependent gain and loss. We show that the reality of the spectrum depends sensitively on the degree of quasi-periodicity for small number of lattice sites. We obtain the Hofstadter butterfly spectrum and discuss the existence of the phase transition from extended to localized states. We show that rapidly changing periodical gain/loss materials almost conserve the total intensity. - Highlights: • We show that PT symmetric Aubry–Andre model may have real spectrum. • We show that the reality of the spectrum depends sensitively on the degree of disorder. • We obtain the Hofstadter butterfly spectrum for PT symmetric Aubry–Andre model. • We discuss that phase transition from extended to localized states exists

  19. PT symmetric Aubry–Andre model

    Energy Technology Data Exchange (ETDEWEB)

    Yuce, C., E-mail: cyuce@anadolu.edu.tr

    2014-06-13

    PT symmetric Aubry–Andre model describes an array of N coupled optical waveguides with position-dependent gain and loss. We show that the reality of the spectrum depends sensitively on the degree of quasi-periodicity for small number of lattice sites. We obtain the Hofstadter butterfly spectrum and discuss the existence of the phase transition from extended to localized states. We show that rapidly changing periodical gain/loss materials almost conserve the total intensity. - Highlights: • We show that PT symmetric Aubry–Andre model may have real spectrum. • We show that the reality of the spectrum depends sensitively on the degree of disorder. • We obtain the Hofstadter butterfly spectrum for PT symmetric Aubry–Andre model. • We discuss that phase transition from extended to localized states exists.

  20. Geología y aspectos geográficos de la isla de san andrés, colombia

    OpenAIRE

    Vargas Cuervo, German

    2012-01-01

    La Isla de San Andrés ha sido definida geológicamente por varios autores en dos unidades calcáreas de características bien marcadas: Una unidad de calizas heterogéneas,denominada como Formación San Andrés de edad Mioceno y una unidad de calizas coralinas de edad Pleistoceno, conocida como Formación San Luis. La primera unidad aflora en la parte central de la isla y representa la zona de colinas suaves con alturas máximas de 87 m.s.n.m y la Formación San Luis constituye la región plana a suave...

  1. Andre on alati tantsida tahtnud / Anu Mõttus

    Index Scriptorium Estoniae

    Mõttus, Anu

    2009-01-01

    Koolitantsu maakonnavoorud on peetud. Igast maakonnast pääsevad piirkonnavooru kuni pooled tantsud. Umbes sama edasipääsuprotsent on ka Andre Laine tantsudel, kelle koolitantsu vaimustus algas Kanepi Gümnaasiumi õpilasena ja kes praeguseks on selle gümnaasiumi tantsupedagoog

  2. André Petermann (1922-2011)

    CERN Multimedia

    2012-01-01

    The CERN theory community mourns the loss of André Petermann, one of the first members of the Theory Division, who passed away last August in his 89th year. He pioneered, together with his advisor Stueckelberg, the renormalization group, one of the fundamental ideas in quantum field theory that underlies the modern theory of phase transitions as well as asymptotic freedom and the quest for unification of all the particle interactions.   André was among the very first staff members of CERN, which at the beginning was a small group of theorists at the Niels Bohr Institute in Copenhagen, headed by Bohr himself.  When the group moved to Geneva, they first occupied a set of barracks in Cointrin, next to the airport, before moving to the University of Geneva, and then finally settling on the Meyrin site. André was our last direct contact with our nomadic origins. The importance of André’s early work on the renormalization group was recogn...

  3. André Rousset 1930-2001

    CERN Multimedia

    2001-01-01

    André Rousset in 1962 , seen working on BP3, one of the earlier bubble chambers, with André Lagarrigue (standing). André Rousset died on 1 July at the age of 70. For those who lived through the Gargamelle epic, his name is linked with the success of the great bubble chamber that made possible the 1973 discovery of neutral currents. A graduate of Paris's famous Ecole Polytechnique which produced so many great names in particle physics, André Rousset, a native of southern France, joined Louis Leprince-Ringuet's famous laboratory at the Polytechnique in 1954. Among other topics, Rousset played a part in the cosmic ray experiments at the Pic du Midi in the Pyrénées and designed heavy liquid bubble chambers. A Professor at the Ecole des Mines from 1960 onwards, he became deputy director of Louis Leprince-Ringuet's laboratory in 1964. In 1969 he came to CERN where, logically, he headed the TCL group in charge of heavy liquid bubble chambers. In thi...

  4. Igale inimesele oma inspektor? / Andre Nõmm

    Index Scriptorium Estoniae

    Nõmm, Andre

    2007-01-01

    Finantsinspektsiooni finantsjärelevalve divisjoni juhataja Andre Nõmm on seisukohal, et finantsinspektsiooni ülesanne ei ole valvata iga kodaniku finantsriski maandamist, vaid vastutust peab kandma iga inimene ise. Ometi on riigi eesmärk tõsta oma kodanike teadlikkust laenuturul valitsevatest ohtudest

  5. Eesti fond rahastab Vene infotehnoloogiat / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2006-01-01

    Martinson Trigon Venture Partners (MTVP) loob uue tarkvarainvesteeringute fondi, mis viib endise NSVL-i alale kuni 780 miljonit krooni, fond võtab sihiks kümmekond uut ettevõtet. MTVP esimese fondi investeeringutest. Fondide juhi Andres Susi selgitusi. Lisa: Martinson Trigon Venture Partners osalusega firmad; Vt. samas: Moskvas pole raha ja geeniused kohtunud

  6. LITERATURA Y DERECHOS DE AUTOR EN EL CIBERESPACIO

    Directory of Open Access Journals (Sweden)

    Ana Carolina Sampaio Coelho

    2010-01-01

    Full Text Available Esta investigación examina la Internet como un medio de comunicación y distribución de la obra de nuevos autores literarios brasileños. Revisamos la historia de la construcción social del autor, desde la tradición oral hasta la contemporaneidad y la adaptación del mercado editorial a los cambios producidos por las nuevas tecnologías de la comunicación. Se establece una comparación entre la publicación que tiene el formato tradicional de papel y los medios digitales. Desde la Teoría de Usos y Gratificaciones, se investigó el sistema de distribución y recepción de estos autores: fue explorado el grado de satisfacción de las relaciones mantenidas con los potenciales lectores de Weblogs y observamos cómo estos autores perciben los derechos de autor en el ciberespacio.

  7. Detection in testis, epididymis and ovary

    Indian Academy of Sciences (India)

    For the first time, we demonstrate that beyond the oviduct,Ovgp1 mRNA is expressed in the testis, epididymis and ovary, but not in the uterus, cervix, vagina, breast, seminalvesicles and prostate gland. In the testis, Ovgp1 mRNA was localized in the cells at the base of seminiferous tubules(most likely, Sertoli cells), while the ...

  8. La conquista interior de la vida. Le Corbusier y André Malraux

    Directory of Open Access Journals (Sweden)

    Ana Sofía Pereira da Silva

    2016-05-01

    Escritos de ambos autores y algunas obras de Le Corbusier –Museo Mundial del Mundaneum y Museo de Crecimiento Ilimitado– serán observados con el sentido de mapear las afinidades existentes entre los dos autores. Sin embargo, las circunstancias pragmáticas de la vida a  menudo se entrometen oponiendo lo que suele estar en consonancia. La clasificación de monumento histórico atribuida por André Malraux a la Villa Savoye, mientras fuera Ministro de los Asuntos Culturales, es presentada con la intuición de salvar una de las obras maestras de Le Corbusier. Sin embargo, esta acción terminó impidiendo al arquitecto encontrar en la degradación de la Villa Savoye un pretexto para su transformación, en una primera fase, vetándole también, finalmente, el proyecto de la  restauración de la casa, que es confiada a un arquitecto de los Monumentos Nacionales.2 Este momento intuido de fricción entre los dos  autores será motivo de observación, no arriesgando la evidente afinidad entre los dos.

  9. Prügitelevisioonist / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2004-01-01

    Kodumaiste kommertstelekanalite saated nagu "Vein ja seltskond", "Kaunis kaunimaks", "Nurgakivi", millele autor vastandab "arrogantse rämpsu" Esto TV saadete näol, kus "trash õilistub kõrgema aate kandjaks"

  10. Gaza võitmatu armaada / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    Katsest viia laevadega humanitaarabi Gaza sektorisse. Autor on arvamusel, et kui Vabaduse laevastik ongi saavutanud soovitu ja murdnud blokaadi, siis uus tasakaal pole julgeoleku mõttes sugugi kindlam

  11. Kliimamuutuste mõju laboratoorium / Andres Tarand

    Index Scriptorium Estoniae

    Tarand, Andres, 1940-

    2001-01-01

    Segadused Ida-Aafrika riikides, nende põhjused. Tabel: Ida-Aafrika riikide mõned arengunäitajad: Etioopia, Sudaan, Somaali, Burundi, Rwanda, Uganda, Tanzania, Keenia. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik

  12. Papillary mesothelioma of the albuginea testis

    NARCIS (Netherlands)

    Tjandra, B. S.; Daemen, M. J.; Weil, E. H.

    1994-01-01

    An eleven-year-old boy is presented with symptom of a torsion of the testis. Scrotal exploration revealed a papillary mesothelioma of the tunica albuginea which is extremely rare in childhood. We report 1 case and review the literature

  13. EL DERECHO DE AUTOR EN COLOMBIA DESDE UNA PERSPECTIVA HUMANISTA

    Directory of Open Access Journals (Sweden)

    Ramiro Rodríguez López

    2012-01-01

    Full Text Available Se considera que el Pacto Internacional de Derechos Económicos, Sociales y Culturales, promulgado por las Naciones Unidas en 1966, determinó la necesidad de garantizar a las personas el derecho a beneficiarse tanto de los intereses morales como de los materiales sobre las creaciones del intelecto, denominadas propiedad intelectual. Al respecto, se considera posible plantear su estudio desde una perspectiva humanista, iniciando el análisis desde la precisión de derechos de autor. Para ello, se estudia su consagración normativa en las constituciones políticas de 1886 y 1991; la importancia de los instrumentos internacionales a los cuales ha adherido el Estado colombiano y su desarrollo en la jurisprudencia nacional, donde se ha hecho una clara referencia del derecho de autor como un derecho contenido en el artículo 27 de la Declaración Universal de los Derechos Humanos de 1948.

  14. Surmahiirte tants; Pühapäeva hommik; Unistus venna külaskäigust; Kolm päeva voodipuhkust; Veepiir; Ei sugutunnuseid ega muid iseärasusi : [Luuletused] / Wallace Stevens ; inglise k. tlk. ja järelsõna: Andres Ehin

    Index Scriptorium Estoniae

    Stevens, Wallace

    1996-01-01

    Autorist lk. 212. Luuletuste 'Unistus venna külaskäigust', 'Kolm päeva voodipuhkust', 'Veepiir' ja 'Ei sugutunnuseid ega muid iseärasusi', mis on samuti ekslikult sealsamas W. Stevensile omistatud, autor on tegelikult Carlos Stewal. Vt. Ehin, Andres. Veavabandus // Looming. 1995. Nr. 5. Lk. 718

  15. UNDESCENDED TESTIS, DIAGNOSIS AND TREATMENT

    Directory of Open Access Journals (Sweden)

    Winarta Lesmana Handrea

    2013-05-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Undescended testis (UDT or cryptorchidism is one of the commonest abnormalities in male infants. In this anomaly, testes are not located normally in the scrotum. The incidence of UDT is 4-5% of term male infants, and 20-33% of premature male infants. The occurrence of abnormalities of hormones control or anatomy process that is required in the normal process of lowering the testes can cause UDT. UDT can be differentiated into palpable and nonpalpable. The diagnosis of UDT can be known through physical examination. However, if the testes are impalpable, laparoscopy can be done to determine the position of the testis. Hormonal therapy to overcome UDT is still under controversy. The action that often done is surgery, called orchidopexy. The most serious complication of orchidopexy is testicular atrophy. It occurs in a small percentage, which is about 5-10%. Infertility may occur in 1 to 3 of 4 adult males and the risk of occurrence of malignancies is increased by as much as 5-10 times higher in men with a history of UDT. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  16. El yo-autor-escritor contemporáneo

    Directory of Open Access Journals (Sweden)

    Everton Vinicius de Santa

    2017-01-01

    Full Text Available Esta reflexión se refiere a la figura del autor una vez que esta figura se traslada al medio digital, esto es, a un espacio donde se puede mirárselo de forma permanente. Ese traslado impone algunos cambios en la elaboración de una entidad autorial por parte del escritor, o sea, la persona física, el individuo que escribe, “l’écrivant”, según Roland Barthes. Este paso al medio digital está deslegitimando la figura del autor de nuestros días y, por ende, cambiando el role del escritor contemporáneo. Así, la reacción por parte del escritor está siendo su espectacularización. Discuto este tema desde el concepto de ego-historias, experiencias personales en el texto en primera persona, por medio de algunas características presentes en dos narrativas: O espírito da prosa (2012, de Cristovão Tezza, y La parte inventada (2014, de Rodrigo Frésan. Busco evidenciar cómo los medios digitales, la cultura digital y mediática en general favorecen una reflexión metaliteraria sobre la invención de un “yo-autor-escritor” que satisface la necesidad del exhibicionismo que los medios digitales proporcionan en la construcción de su imagen.

  17. Direito autoral e o livro eletrônico

    Directory of Open Access Journals (Sweden)

    Helen Beatriz Frota Rozados

    2014-06-01

    Full Text Available Este artigo discorre sobre os novos desafios decorrentes do livro eletrônico no que tange ao direito autoral. Para tanto, utiliza-se de pesquisa bibliográfica para levantar e analisar as características do direito autoral e as propostas de mudanças na legislação brasileira,e descreve as novas formas de proteção desenvolvidas a fim de disponibilizar as obras ao público bem como proteger os direitos autorais. São abordados o Copyleft, Digital Right Management (DRM e o Creative Commons dentre as novas formas de proteção. Conclui-se que o livro eletrônico tem propiciado uma gama de novas discussões no âmbito do mercado editorial e pelos legisladores, levando a uma necessária reflexão, mais intensa, que possa propiciar efetivas mudanças na legislação sobre direito autoral, mudanças estas que englobem um melhor controle do processo de acesso, uso e divulgação, seja para impedir ações ilegais, uso da informação sem a devida creditação, plágio e ou a proliferação de cópias não permitidas.

  18. Andres Võsand: hakkan ilmselt elukutseliseks kunstnikuks / Andres Võsand ; intervjueerinud Veiko Visnapuu

    Index Scriptorium Estoniae

    Võsand, Andres, 1966-

    2010-01-01

    Intervjuu Saksaamaal elava tennisisti Andres Võsandiga, kelle maalinäitus "Värvireisid" on avatud Kadriorus Kastellaanimaja Galeriis 30.10-28.11.2010. Tegelemisest maalikunstiga, näitusest, reisidest inspireeritud loomingust, tööst tennisetreenerina, tennisekarjäärist. Andmeid A. Võsandi elukäigu kohta

  19. Primary lymphoma of the testis

    International Nuclear Information System (INIS)

    Buskirk, S.J.; Evans, R.G.; Banks, P.M.; O'Connell, M.J.; Earle, J.D.

    1982-01-01

    Seventeen patients with initial presentation of lymphoma of the testis were evaluated at the Mayo Clinic between 1969 and 1979. The mean age of the patients was 69 years with 15 of the 17 patients age 60 and older at the time of diagnosis. All histologies were diffuse according to the Rappaport classification with 12 of 17 patients being histiocytic. Eleven of the 15 State I/sub E/A and II/sub E/A patients were treated with radiation therapy alone with doses ranging from 2,600 to 4,000 rad. Eight of these 11 Stage I/sub E/A patients experienced recurrence; in five of these eight, the first site of recurrence was Waldeyer's ring and adjacent structures. Four patients were treated initially with chemotherapy. In all four patients the lymphoma recurred, in two patients in the central nervous system (CNS). The survival rate at two years was 73% in Stage I/sub E/A patients and 25% in Stage II/sub E/A patients. There were no survivors at two years in those patients presenting with Stage IV disease. As patients with testicular lymphoma have a relatively high incidence of secondary involvement of Waldeyer's ring and the CNS, careful evaluation of these areas should be performed as part of the routine staging procedures. In view of the high incidence of secondary involvement of distant sites, systemic treatment should be given full consideration in addition to local irradiation as part of the initial treatment of patients with localized disease

  20. Trisomía 21: autoría reivindicada

    Directory of Open Access Journals (Sweden)

    Horacio Rivera

    2016-01-01

    Full Text Available Esta reseña recapitula diversas circunstancias relativas al descubrimiento en 1958-1959 de la trisomía 21 propia del síndrome de Down y a la participación de los tres autores protagonistas. En particular, se subraya que fue Marthe Gautier quien en realidad hizo los cultivos celulares, analizó las metafases y se percató que los pacientes con síndrome de Down tenían 47 cromosomas. En consecuencia, es claro que su crucial contribución no había recibido, hasta la actualidad, el crédito apropiado.

  1. Kas Euroopas olid CIA salavanglad? / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2006-01-01

    Dick Marty raportist USA Luure Keskagentuuri (CIA) oletatavatest salavanglatest Euroopas. Autor on seisukohal, et Euroopal tuleb igal juhul välja selgitada tõde CIA salavanglate olemasolu kohta, sest vastasel korral saab Venemaa argumendi inimõigustevastase tegevuse kaitseks. Vt. samas: CIA salavanglad ja -lennud Euroopas

  2. Maksude langus on trend / Andres Lipstok

    Index Scriptorium Estoniae

    Lipstok, Andres, 1957-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti 14. apr. lk. 10; Paremad Uudised apr. nr. 4 lk. 7. Autor analüüsib Eesti maksupoliitikat ning leiab, et nii ettevõtluse maksustamise vähendamine kui üksikisiku tulumaksu alandamine on hädavajalik riigi majanduse elavdamiseks ning Eesti majandusliku arengu viimiseks EL-i liikmesriikide tasemele

  3. Vene faktor ehk poloonium 210 / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2007-01-01

    Autor mõtestab lahti nn pärsitud kriitika sündroomi, mille järgi Mihhail Gorbatshovist alates on Vene võimu saatnud üks kustumatu müüt: Vene võimuga peab leppima, sest olukord on plahvatusohtlik ja uus, mis tuleb, on kindlasti hullem

  4. Activin receptor subunits in normal and dysfunctional adult human testis

    DEFF Research Database (Denmark)

    Dias, V; Meachem, S; Rajpert-De Meyts, E

    2008-01-01

    The cellular sites of activin action and its regulation in the normal and dysfunctional adult human testis are unknown.......The cellular sites of activin action and its regulation in the normal and dysfunctional adult human testis are unknown....

  5. Development and descent of the testis in relation to cryptorchidism

    DEFF Research Database (Denmark)

    Virtanen, Helena E; Cortes, Dina; Rajpert-De Meyts, Ewa

    2007-01-01

    The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown...... and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis....

  6. Possible Factors that Affect Testis Volume in Varicocele Patients

    Directory of Open Access Journals (Sweden)

    Ozay Demiray

    2015-06-01

    Conclusion: Left varicocele degree is associated with decrease in testis volume. There was no relationship between testis volume and body mass index or smoking habit. Early varicocele diagnosis is important to protect testis volume. [Cukurova Med J 2015; 40(2.000: 233-238

  7. ¿Tutoría o autoría?

    Directory of Open Access Journals (Sweden)

    Targino, María das Graças

    2011-05-01

    Full Text Available En español: A lo largo del tiempo, con los profundos cambios en la enseñanza e investigación provenientes de los avances tecnológicos, y sobre todo por el valor creciente de la educación superior y de la investigación científica, hay intensas controversias alrededor del viejo y gastado lema "publicar o morir”. Cada vez más, tutores o directores de tesis y monografías académicas en general, se colocan como primer autor o coautor de los trabajos realizados por sus alumnos, utilizando el argumento de que la autoría, como actividad y proceso, sufre ella misma intensas mutaciones sociales, culturales, económicas y políticas. Este es un tema que despierta discusiones y conduce a cambios conceptuales que requieren la reconstrucción de sus fundamentos, ya que con respecto de la cuestión ética, debe tenerse en cuenta.In english: Over time, with the profound changes in the learning and in research provided by technological advances, and especially because of the extreme value of higher education and scientific research, there is an intense discussion around the old and worn slogan "publish or perish". Increasingly, mentors or directors of thesis and university papers, en general, put themselves as first author or coauthor of work performed by their students, by the argument that the author, as activity and process, suffers herself social, cultural, economic and political mutations. This is a topic that arouses controversy and leads to conceptual changes, which require the deconstruction of its foundations, which, however, must respect the ethic behaviour.

  8. Andrés Rivera, Escritor social

    Directory of Open Access Journals (Sweden)

    Marta Waldegaray

    2006-07-01

    Full Text Available La narrativa de Andrés Rivera hace de la historia el material de origen de la escritura y de su convicción política de izquierda el molde en el cual desde hace ya más de cuatro décadas su escritura adquiere forma.Acontecimiento histórico, circunstancia política, poseen en sus primeras novelas el valor de verdad política, de testimonio social. La convicción ideológica que sus libros exhiben se acompaña de una trayectoria literaria que, en su práctica inicial, fue confiada a la representación r...

  9. Suicide in men with testis cancer.

    Science.gov (United States)

    Alanee, S; Russo, P

    2012-11-01

    Depression, anxiety and aggression are documented in testis cancer patients and can result in death from suicides; however, their risk of suicide is not defined. We report suicide rates among testis cancer patients in the USA and determine factors associated with higher rates. We used the Surveillance, Epidemiology, and End Results (SEER) database maintained by the National Cancer Institute to identify patients diagnosed with testis cancer between 1995 and 2008. Multivariate analysis was used to assess factors affecting suicide rate. Among 23,381 patients followed for 126,762 person-years, suicide rate was 26.0 per 100,000 person-years, with the average corresponding rate in the US population aged 25-44 years being 21.5 per 100,000 person-years; the calculated standardised mortality ratio for death by suicide was 1.2 [95% confidence interval (CI): 1.1-2.1]. The standardised mortality ratio for suicide was 1.5 (95% CI: 1.1-2.1) in ages less than 30 years, and 1.8 (95% CI: 1.3-2.4) in men of races other than White and Black. Other patient and disease characteristics were not predictive. In conclusion, patients with testis cancer have a 20% increase in the risk of suicide over that of the general population, and races other than White and Black and younger patients may commit suicide at higher rates. © 2012 Blackwell Publishing Ltd.

  10. Eesti Energia esindused = Eesti Energia branches / Andres Labi, Janno Roos

    Index Scriptorium Estoniae

    Labi, Andres, 1977-

    2013-01-01

    Eesti Energia klienditeeninduse kontorite sisekujundusest. Autorid: Janno Roos, Andres Labi ja Liisa Põime (Ruumilabor). Visuaalne identiteet: Tank.Teenuste disain: Urmas Pastarus. ESLi aastapreemiate žürii esimehe Kaido Kivi ning žürii liikme Raivo Puusepa arvamused

  11. Jumalaema kiriku kellamees tuli Tartu Toome varemetesse / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    13. juulil esietendus Emajõe Suveteatris "Jumalaema kiriku kellamees". Victor Hugo romaani järgi tegi instseneeringu Urmas Lennuk, lavastaja Andres Dvinjaninov. Mängitakse Tartu Toomkiriku varemetes

  12. "Vettpidavad allikad" = "Watertight sources" / Janno Roos, Andres Labi

    Index Scriptorium Estoniae

    Roos, Janno, 1976-

    2013-01-01

    Eesti Ajaloomuuseumis avatud näituse kujundasid Janno Roos ja Andres Labi (Ruumilabor). Kuraator Krista Sarv. Graafiline disain: Identity. Eksponeeritud allveeuuringute käigus leitu. Arhitektuuriajaloolase Leele Välja arvamus

  13. Andres Tolts 60 : omanäoliste vaikelude imeline maailm / Andres Tolts ; intervjueerinud Tiina Kolk ; kommenteerinud Jaan Elken

    Index Scriptorium Estoniae

    Tolts, Andres, 1949-2014

    2009-01-01

    Andres Toltsi näitused "Asjad" Hobusepea galeriis 12. oktoobrini, "Näitus" Tallinna Kunstihoones 25. oktoobrini, "Varane Tolts" Haus galeriis 13. novembrini. Pikemalt näitusest "Näitus", kuraator Harry Liivrand

  14. La televisión Colombia es de autor

    Directory of Open Access Journals (Sweden)

    Omar Rincón

    2015-05-01

    Full Text Available Colombia tiene una marca narrativa en televisión. Somos el país de Yo soy Betty, la fea y Café con aroma de mujer y por eso Fernando Gaitán es nuestro gran contador cultural, así como lo fue antes García Márquez y su realismo mágico o Botero y sus gorditos divertidos. Nuestra marca Colombia de ficción televisiva se caracteriza por ser esa que hace otro melodrama e intenta otras éticas y estéticas, que innova y emociona distinto. Una ficción de autor. Eso comenzó desde el 13 de junio de 1954 cuando se inauguró la pequeña pantalla para conmemorar el primer año de gobierno del general Rojas Pinilla. En la primera emisión El niño del pantano, una breve de ficción adaptada para televisión de un cuento original de Bernardo Romero Lozano, ya marcaba el rumbo. Desde ese primer día la televisión colombiana buscó ser una mezcla entre lo de élite y lo popular, entre el gran drama y la comedia.

  15. CUANDO LOS DOCENTES SE CONVIERTEN EN AUTORES DE TEXTO

    Directory of Open Access Journals (Sweden)

    Maria Sol Caríssimo

    2015-12-01

    Full Text Available Este trabajo relata una experiencia realizada por diferentes docentes como capacitación permanente. En el marco de "escribir textos de ciencias para el nivel terciario", se nos brindó la posibilidad de aprender a escribir ciencias, en el mas amplio sentido de la frase. Para llevar a cabo esta tarea y ver finalizada la obra, pasamos 1 año y varios meses trabajando en grupo, investigando, leyendo, escribiendo, releyéndonos y  reescribiendo. El aporte de esta experiencia es inmensurable, sobre todo si de estrategias de enseñanza e investigación se trata. La producción de textos resulta sumamente rica por la cantidad de relaciones que por ella se traman, la génesis constante entre colegas, eruditos acompañantes, nivel de lectura, tipos de textos leídos (muchísimos para la enseñanza de la escritura, además de los científicos y lo que todo esto deposita en el educador/autor. Los docentes que participamos del mismo, concluimos que la capacidad de brindar las clases específicas, su calidad, utilizando nuevos y mejores métodos de enseñanza aprendizaje es superior a las dictadas previamente; fuimos capaces de reconocer el transe en el proceso de E-A durante el periodo que llevamos a cabo la escritura; pudimos autoevaluarnos, ser críticos de nuestra propia labor, planificando un cómo mucho mejor.

  16. Andres Tali sõnavõtt ettekannete päeval = Andres Tali's speech given on the lecture day / Andres Tali

    Index Scriptorium Estoniae

    Tali, Andres, 1956-

    2006-01-01

    Kaasaegse Kunsti Eesti Keskuse ettekannete päev "Kunstnike moraalsed valikud kultuurikonfliktides" 27.04.2006 Tallinna Kunstihoones. Oma installatsioonist "Pastoraalne pastishsh" ning videost "Vägivald ja propaganda - The Movie" samas 8.04.-28.05.2006 avatud Elin Kardi, Marko Mäetamme, Marco Laimre ja Andres Tali ühisnäitusel "Vägivald ja propaganda"

  17. Vi har uddelegeret forbruget og nydelsen til Netflix og de andre teknologigiganter

    DEFF Research Database (Denmark)

    Bak Herrie, Maja

    2018-01-01

    https://www.information.dk/debat/2018/05/uddelegeret-forbruget-nydelsen-netflix-andre-teknologigiganter......https://www.information.dk/debat/2018/05/uddelegeret-forbruget-nydelsen-netflix-andre-teknologigiganter...

  18. Cystic dysplasia of the testis: a very rare paediatric tumor of the testis.

    Science.gov (United States)

    Eberli, Daniel; Gretener, Heini; Dommann-Scherrer, Corina; Pestalozzi, Dietegen; Fehr, Jean-Luc

    2002-01-01

    To describe a case of cystic dysplasia of the testis (CDT), an uncommon cause of scrotal swelling in the pediatric patient. Clinic, therapy, fertility, and radiographic and pathologic findings are discussed and the 30 previously reported cases are reviewed. A 9-year-old boy presented with asymptomatic scrotal swelling. A scrotal ultrasound showed a multicystic scrotal mass in the rete testis and an ipsilateral renal agenesis. The growth in size of the mass forced the authors to perform an operative exploration. Intraoperative findings included a multicystic mass in the rete testis of the right testicle. Testicle-sparing total removal of the multicystic mass was performed and the pathologic examination revealed a benign, multilobulated configuration of the cysts in the region of the rete testis. These findings were similar to those found in previously reported cases of CDT. Ipsilateral renal agenesis is the most common associated anomaly. As a pathogenetic factor, mal-junction of the Wolffian duct in the 5th week of gestation is most creditable. CDT is a rare cause of pediatric scrotal mass. When feasible, a testicle-sparing approach should be considered and all patients should undergo evaluation for associated urologic anomalies.

  19. Les mots du jazz. Retour(s) sur Le Jazz, d'André Schaeffner et André Coeuroy

    OpenAIRE

    Roueff , Olivier

    2001-01-01

    International audience; Le Jazz by André Schaeffner and André Cœuroy (1926), the first learned analysis of jazz, signaled an important phase in the reinvention of this music in France, since, through the debates it sparked at the time, it helped change jazz’s identity from an « American » to a « Black American » music with African « roots ». Cœuroy and Schaeffner referred to sorts of music that jazz criticism would have throw out of its pantheon, but their analyses would form the major grids ...

  20. El concepto de autor en la obra de Gérard Genette

    OpenAIRE

    Roger, Julien

    2009-01-01

    El objeto de esta ponencia es, mediante un examen de las ocurrencias del término autor bajo la pluma de Genette, esencialmente en Figures III y Palimpsestes, intentar demostrar que el concepto de autor, lejos de ser deleznable, como para buena parte de la Nouvelle Critique, constituye una llave hermenéutica para entender su obra.

  1. Ectopic Splenic Tissue in the Testis: A Case Report

    African Journals Online (AJOL)

    Ectopic SplENic tiSSUE iN thE tEStiS associated with bilateral cryptorchidism and hypospadias4. Brasch et al. reported a case involving the right testis5. Ultrasonography, scintigraphy (with technetium-99m) and single positron emission computerized tomography are considered the best diagnostic tools for this condition2,3.

  2. Absent testis: does it exist in 46,XY males?

    African Journals Online (AJOL)

    laparoscopy, the vas and testicular vessels are traced as ... Methods Both Mullerian inhibitory factor and testosterone act locally as ... Surg 9:79–80 c 2013 Annals of Pediatric Surgery. ... Unilateral absent testis should be associated ... Absent testis during groin exploration ... visualized at laparoscopic or open exploration.

  3. Prevalence of Undescended Testis and its Associated Factors ...

    African Journals Online (AJOL)

    Prevalence of Undescended Testis and its Associated Factors among under-fives seen at Reproductive and Child Health Clinic in Ifakara, Tanzania. ... The male sexual differentiation and development is important for the normal reproductive life span. Similarly, risk of carcinoma of testis will be prevented, if early diagnosis of ...

  4. Molecular cloning and characterization of a novel human testis ...

    Indian Academy of Sciences (India)

    Molecular cloning and characterization of a novel human testis-specific gene by use of ... pared against 70 other libraries, and the hits showing >10- fold differences .... proteins or testis-development-related proteins such as TSP-. NY, TPX1 ...

  5. An oncological view on the blood-testis barrier

    NARCIS (Netherlands)

    Bart, J; Groen, HJM; van der Graaf, WTA; Hollema, H; Hendrikse, NH; Vaalburg, W; Sleijfer, DT; de Vries, EGE

    The function of the blood-testis barrier is to protect germ cells from harmful influences; thus, it also impedes the delivery of chemotherapeutic drugs to the testis. The barrier has three components: first, a physicochemical barrier consisting of continuous capillaries, Sertoli cells in the tubular

  6. utilization of crude testis extract to enhance broiler production

    African Journals Online (AJOL)

    EKWUEME

    0.05) while profit per bird and profit over cost of ... effects of different levels of testis extracts in drinking water on ... water. Treatment A served as the control with no testis extract ..... organized by B. B. Vet. Medical ... Maximizing yield. Poultry Sci.

  7. Imaging of mesothelioma of tunica vaginalis testis

    Energy Technology Data Exchange (ETDEWEB)

    Bertolotto, M. [University of Trieste, Department of Radiology, Trieste (Italy); Boulay-Coletta, I. [Fondation Hopital Saint Joseph, Service d' Imagerie Medical, Paris (France); Butini, R. [Ospedale S. Giacomo, Department of Radiology, Castelfranco Veneto, TV (Italy); Dudea, S.M. [Univ. Med. Pharm. ' ' Iuliu Hatieganu' ' , Department of Radiology, Cluj-Napoca (Romania); Grenier, N. [Pellegrin Hospital, Department of Radiology, Bordeaux (France); Oltmanns, G. [University Hospital of North Norway, Department of Radiology, Tromsoe (Norway); Ramchandani, P. [University of Pennsylvania, Department of Radiology, Perelman School of Medicine, Philadelphia, PA (United States); Stein, M.W. [Montefiore Medical Center, Department of Radiology, Albert Einstein College of Medicine, Bronx, NY (United States); Valentino, M. [Sant' Antonio Hospital, Department of Radiology, Tolmezzo, UD (Italy); Derchi, Lorenzo E. [University of Genoa, Department of Health Sciences, Genova (Italy); IRCCS Azienda Ospedaliera Universitaria San Martino IST, Radiologia d' Urgenza, Genova (Italy)

    2016-03-15

    To describe the imaging findings in a series of patients with mesothelioma of the tunica vaginalis testis. We reviewed clinical data, imaging findings and follow-up information in a series of 10 pathology-proven cases of mesothelioma (all had US; 2 had MR) of the tunica vaginalis. A variety of patterns could be observed, the most common (5/10) being a hydrocele with parietal, solid and hypervascular vegetations; one patient had a septated hydrocele with hypervascular walls; one had multiple, solid nodules surrounded by a small, physiological quantity of fluid; one a cystic lesion with thick walls and vegetations compressing the testis; two had a solid paratesticular mass. MR showed multiple small nodules on the surface of the tunica vaginalis in one case and diffuse thickening and vegetations in the other one; lesions had low signal intensity on T2-w images and were hypervascular after contrast injection. A preoperative diagnosis of mesotheliomas presenting as solid paratesticular masses seems very difficult with imaging. On the contrary, the diagnosis must be considered in patients in whom a hydrocele with parietal vegetations is detected, especially if these show high vascularity. (orig.)

  8. Mis siis juhtus Andres Lapeteusega? / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie

    2011-01-01

    Režissöör Grigori Kromanovi filmist "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1965). Osades: Einari Koppel, Ita Ever, Heino Mandri, Kaljo Kiisk, Uno Loit, Ada Lundver jt. Lühidalt filmi kohta ilmunud arvustustest. Filmi näeb ETV2-s sarjas "Unustatud filmid"

  9. Peaosa nii teatrilaval kui ka kinolinal / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    Natalja Murina-Puustusmaast, kes mängib peaosa Vene Teatri uuslavastuses "Besame mucho", mille Afolf Käis on lavastanud Eduardo de Filippo näidendi "Silinder" järgi, ja Andres Puustusmaa filmis "Rotilõks", mille võtted algavad peagi

  10. Kino, Theater, Fernsehen : André Bazins Publikumstheorie

    NARCIS (Netherlands)

    Hanich, Julian; Mundhenke, Florian; Weber, Thomas

    2017-01-01

    What did the great French film theorist André Bazin think of the collective experience in the cinema? What did he write about the influence co-viewers can have on the emotional engagement, the evaluation and the interpretation of a film? In short: What was his audience theory? To be sure, Bazin is

  11. Parts harvendas ootamatult Eesti Energia nõukogu / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2011-01-01

    Majandus- ja kommunikatsiooniminister Juhan Parts otsustas 1. juulil päevapealt Eesti Energia nõukogu liikme kohalt tagasi kutsuda Aivar Reiviku ning Rein Kuusmiku, kes olid vastu Eesti Energia üle viie miljoni euro suurusele investeeringule Weroli rapsiõlitehase juurde rajatavasse elektri- ja küttejaama. Uuteks nõukogu liikmeteks said Andres Saame ja Toomas Tauts

  12. Mis on looming.org? : elektrooniline heli / Andres Lõo

    Index Scriptorium Estoniae

    Lõo, Andres

    2004-01-01

    Võrguajakirjast www.looming.org, kuhu kogutakse infot põhiliselt kahe jaotuse põhjal: muusika ja helieksperimentalism ning kaasaegne kunst, kunsti ja meediaga seonduv. Idee autorid: Hanno Soans ja Andres Lõo. Ilmunud on looming.orgi esimene muusikakogumik "Lilled algebrale"

  13. 2623-IJBCS-Article-Gadji Alahou André

    African Journals Online (AJOL)

    hp

    1. Alahou André Gabazé GADJI1,2*, Ossey Bernard YAPO1, Kouabenan ABO2,. Ladji MEITE1, Agnès Eude Yves GNAGNE1, Satinder Kaur BRAR 3 et. Rajeshwar Dayal TYAGI4. 1Laboratoire des Sciences de l'Environnement (LSE), Unité de ...

  14. Andres Sütevaka näitus Stockholmis

    Index Scriptorium Estoniae

    2000-01-01

    Sütevaka Andrese abstraktsete maalide näitus Stockholmi Eesti Majas. Sütevaka Andres ja näituse avamisele sõitnud tema loomingu kollektsionäär Matti Milius kohtusid Moderna Museeti direktori David Elliotiga teadvustamaks Tartu ja Pärnu kunstielu.

  15. André François Boshoff

    African Journals Online (AJOL)

    Campbell Murn

    1945-2016) and pay tribute to him. An only child, André spent most of his childhood in very remote areas of southern Africa due to his magistrate father's various postings. Such locations, for example coastal. Transkei and the Caprivi Strip, instilled ...

  16. Kommest Auto ostmisest huvitub ka Hillar Teder / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2008-01-01

    Kommest Auto ostmise vastu tunnevad huvi suurärimees Andres Sarri, Rootsis Peugeot' sõidukeid müüv Taani päritolu K. W. Bruun Import ja multimiljonär Hillar Teder, kellele kuulub Audisid müüv Reval Auto

  17. Effect of the anti-androgenic endocrine disruptor vinclozolin on embryonic testis cord formation and postnatal testis development and function.

    Science.gov (United States)

    Uzumcu, Mehmet; Suzuki, Hiroetsu; Skinner, Michael K

    2004-01-01

    Vinclozolin is a systemic dicarboximide fungicide that is used on fruits, vegetables, ornamental plants, and turf grass. Vinclozolin and its metabolites are known to be endocrine disruptors and act as androgen receptor antagonists. The hypothesis tested in the current study is that transient embryonic exposure to an anti-androgenic endocrine disruptor at the time of testis determination alters testis development and subsequently influences adult spermatogenic capacity and male reproduction. The effects of vinclozolin on embryonic testicular cord formation in vitro were examined, as well as the effects of transient in utero vinclozolin exposure on postnatal testis development and function. Embryonic day 13 (E13, sperm-positive vaginal smear day = E0) gonads were cultured in the absence or presence of vinclozolin (50-500microM). Vinclozolin treated gonads had significantly fewer cords (P vinclozolin (100 mg/kg/day) between embryonic days 8 and 14 (E8-E14) of development. Testis morphology and function were analyzed from postnatal day (P) 0, pubertal P20, and adult P60. No significant effect of vinclozolin on testis histology or germ cell viability was observed in P0 testis. The pubertal P20 testis from vinclozolin exposed animals had significantly higher numbers of apoptotic germ cells (P vinclozolin exposed males (P vinclozolin exposed animals was higher in adult P60 animals. Observations demonstrate that vinclozolin can effect embryonic testicular cord formation in vitro and that transient in utero exposure to vinclozolin increases apoptotic germ cell numbers in the testis of pubertal and adult animals. This correlated to reduced sperm motility in the adult. In conclusion, transient exposure to vinclozolin during the time of testis differentiation (i.e. cord formation) alters testis development and function. Observations indicate that transient exposure to an anti-androgenic endocrine disruptor during embryonic development causes delayed effects later in adult life

  18. Molecular and cellular endocrinology of the testis

    International Nuclear Information System (INIS)

    Stefanini, M.; Conti, M.; Geremia, R.; Ziparo, E.

    1986-01-01

    This volume contains the Proceedings of the IV European Workshop on Molecular and Cellular Endocrinology of the Testis held in Capri (Italy) between the 9th and 12th April 1986. The workshop was organized in several symposia related to some of the most relevant aspects of the regulation of testicular function. Main topics were the role of cell interactions, the mechanisms of signal transduction, gene expression and metabolic response of somatic cells as well as differentiation of germ cells. One session was devoted to prostaglandins in the male reproductive system and to brief discussions on interstitial fluid and on antispermatogenic compounds. In this book only the main lectures and some selected short papers are presented. (Auth.)

  19. "Ich war nicht der allmächtige Autor" / Simon Stephens ; intervjueerinud Jacqueline Bolton

    Index Scriptorium Estoniae

    Stephens, Simon, 1971-

    2012-01-01

    NO99 teatris esietendunud kolme teatri - NO99, Münchner Kammerspiele, Lyric Hammersmith Theatre - koostöös valminud lavastuse "Three Kingdoms" ("Kolm kuningriiki") teksti autor Simon Stephens räägib

  20. Autoralli MM-sarja ootab ees vaheaasta / Ivo Dobkevitš ; fotod Karli Saul

    Index Scriptorium Estoniae

    Dobkevitsch, Ivo, 1973-

    2009-01-01

    Tehasetiimide majandusraskustest ja vähesest huvist autoralli MM-sarja vastu 2009. aastal ning FIA poolt kehtestatavatest tehnilistest muudatustest 2010. aastal. Samas: Urmo Aava hooaega vahele jätta ei kavatse

  1. Dividend sõi kasumi ära / Andres Root

    Index Scriptorium Estoniae

    Root, Andres, 1956-

    2004-01-01

    Autor selgitab, miks kajastatakse välja makstud dividende kasumiaruandes ja näitab, kuidas see mõjutab ettevõtte finantstulemust. Tabelid: Kasumi kujunemine ja tulu maksustamine; Ettevõtte omakapital

  2. Laparoscopic classification of the impalpable testis: an update

    African Journals Online (AJOL)

    intra-abdominal testis should be treated by standard open ... laparoscopy at two tertiary centers of Pediatric surgery in Egypt ... patients, 25 (21%) had bilateral NPT, whereas the rest .... inguinal approach with transperitoneal extension should.

  3. Testicular development and relationship between body weight, testis ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-03-20

    Mar 20, 2009 ... INTRODUCTION. A major determinant of the reproductive performance of ... testis weight as one of the indices in selecting high quality breeding ... equipment (AV and collection bottles) as described by Swierstra and Rahnfeld ...

  4. Tallinna Lennujaama kauba- ja tolliterminaal. Lennujaama 2, Tallinn / Andres Põime

    Index Scriptorium Estoniae

    Põime, Andres

    1998-01-01

    Kaubateeninduskeskuse puhul on tegemist suure, plaanimõõtudes 36x102 meetrise metallkonstruktsioonis, sandwich tüüpi paneelidega kaetud laohoonega, kus ühelt poolt tuuakse tollitav kaup lennukitelt sisse ja teiselt poolt viiakse tollitud kaup välja. Peatöövõtja : Normanni Linnagrupi AS. Ehitaja : Merko. Peaprojekteerija : K-Projekt. Arhitektuurne lahendus : Stuudio 3. Arhitekt Andres Põime ; töögrupp Vivian Oruvee, Tiiu Raudsepp, Reet Põime. Projekt 1997-98, valmis 1998.

  5. André Lefevere and his Manipulation School

    OpenAIRE

    Šmrha, Jan

    2015-01-01

    This theoretical and historiographical thesis examines the theoretical work of the Translation Studies scholar André Lefevere. It focuses primarily on the analysis of Lefevere's work in the context of the development of Translation Studies (particularly in connection with the development of Descriptive Translation Studies, the formation of the "Manipulation School" and the cultural and sociological turns in Translation Studies). The thesis covers Lefevere's theoretical underpinnings, the grad...

  6. Sobre "La tortuga" de Andrés Holguin

    Directory of Open Access Journals (Sweden)

    José Puben

    1961-04-01

    Full Text Available Andrés Holguín no es el primero y, ciertamente, no será el último escritor contemporáneo que, interesado por el problema de los animales que han logrado dimensión fantástica, se proponga, con interés intelectual, analizar e investigar la dimensión e importancia de un animal en la historia de la cultura.

  7. Mida teeks tulevane kultuuriminister 500 miljoni krooniga? / interv. Andres Keil

    Index Scriptorium Estoniae

    2007-01-01

    Suuremate erakondade kultuurispetsialistid (kultuuriministrikandidaadid) Urmas Paet, Andres Herkel, Peeter Jalakas, Indrek Saar, Jaak Allik, samuti kultuuriminister Raivo Palmaru vastavad küsimustele, mis on suurimad ohud eesti keele ja rahvuskultuuri säilimisele, milline on kultuuriministeeriumi ja -ministri portfelli staatus praeguses valitsuses, kas kultuuri rahastamine riigieelarvest on piisav, mille poolest erineb nende erakonna nägemus kultuuripoliitikast teiste erakondade omast, kuhu nad suunaksid 50, 500 miljonit, kui see oleks nende käsutuses

  8. Revolver, kala ja harmoonia / Andres Tolts ; intervjueerinud Kadri Karro

    Index Scriptorium Estoniae

    Tolts, Andres, 1949-2014

    2009-01-01

    Andres Toltsi juubelinäitused Tallinnas: "Näitus" Tallinna Kunstihoones 25.9-25.10, "Asjad" Hobusepea galeriis 30.9-12.10, "Juubelinäitus" Haus galeriis 8.10-13.11. Kunstnik räägib oma loomingust, revolvri ja kala motiivist oma töödes, mõttekaaslusest, eestiaegsest maailmavaatest, harmooniast ja isikupärast kunstis ning elus, ilust ja inetusest, kaasaja kunstnike vajadusest oma loomingut sõnade abil seletada

  9. ALTERATIONS IN THE DEVELOPING TESTIS TRANSCRIPTOME FOLLOWING EMBRYONIC VINCLOZOLIN EXPOSURE

    OpenAIRE

    Clement, Tracy M.; Savenkova, Marina I.; Settles, Matthew; Anway, Matthew D.; Skinner, Michael K.

    2010-01-01

    The current study investigates the direct effects of in utero vinclozolin exposure on the developing F1 generation rat testis transcriptome. Previous studies have demonstrated that exposure to vinclozolin during embryonic gonadal sex determination induces epigenetic modifications of the germ line and transgenerational adult onset disease states. Microarray analyses were performed to compare control and vinclozolin treated testis transcriptomes at embryonic day 13, 14 and 16. A total of 576 di...

  10. Kutseharidust hakkab muutma uus paradigma / André Huigens ; intervjueerinud Veiko Belials

    Index Scriptorium Estoniae

    Huigens, André

    2011-01-01

    Intervjuu Luual toimunud rahvusvahelise kutsehariduse alase seminari peaesineja, André Huigensiga, kes on Euroopa kutseõppe arenduskeskuse Cedefop kvalifikatsiooniraamistiku ekspert Hollandi Wellantcollege’ist

  11. DE LA MUERTE DEL AUTOR A LA MUERTE DEL ARTISTA: REFLEXIÓN CRÍTICA PARA UN DEBATE EN TORNO A LA FIGURA DEL AUTOR

    Directory of Open Access Journals (Sweden)

    Ricardo Arcos-Palma

    2011-04-01

    Full Text Available La "muerte del autor" se ha convertido en el paradima de la postmodernidad. El siguiente ensayo realiza un análisis crítico de tal expresión y las consecuencias de su aplicación en el mundo del arte contemporáneo. La tesis planteada es la siguiente: la muerte del autor trae consigo la muerte del artista y del crítico, figuras representativas de la autoridad. Tales muertes generan el nacimiento de una nueva figura de poder que es el curador. Con este texto se pretende aportar elementos de reflexion para un debate, que apenas comienza, en torno a la figura del curador.

  12. Treatment of impalpable testis - one clinic's experience.

    Science.gov (United States)

    Osemlak, Paweł; Żądkowski, Tomasz; Rogowski, Błażej; Cielecki, Czesław; Wieczorek, Andrzej; Woźniak, Magdalena; Jędrzejewski, Grzegorz; Beń-Skowronek, Iwona; Nachulewicz, Paweł

    2017-06-01

    Undescended testes are recognised in 1% to 2% of boys during the first year of life, and about 20% of them are impalpable. Ultrasonography (US) may establish the localisation of the testis but the final diagnosis is usually determined laparoscopically. To evaluate long-term results of laparoscopic treatment of boys with impalpable testes and sensitivity of preoperative ultrasound. Between 2011 and 2015, we operated on 545 boys with undescended testes. Sixty-two of them with 65 impalpable testes were treated laparoscopically - the study group. Mean age was 3.5 years. The study group was divided into 5 groups according to type of treatment. The volume and position of the operated gonad were assessed manually and by ultrasound. In group 1 testicular agenesis was observed in 19 patients. In group 2 revision of the inguinal canal revealed testicular agenesis in 7 and atrophy in 4 patients. In group 3 conversion to classic orchiopexy was performed in 10 patients. In group 4 one-stage orchiopexy was performed in 9 patients on 12 testes. In group 5 a two-stage F-S procedure was performed in 13 patients. Ten testes in group 4 had a volume in the normal range (84%) and also 10 testes in group 5 (77%). Laparoscopy in impalpable testes is the procedure of choice and allows definitive management, even when conversion to open procedure is necessary. Sensitivity of preoperative ultrasound is generally about 60% for true intra-abdominal testes, so diagnostic laparoscopy is necessary.

  13. Human testis-expressed sequence 101 is limitedly distributed in germinal epithelium of testis and disappears in seminoma

    Directory of Open Access Journals (Sweden)

    Cong-Cong Shen

    2014-01-01

    Full Text Available BACKGROUND: Testis-expressed sequence 101 (TEX101 was found to be highly expressed in testis and involved in acrosome reaction in previous studies. Recently, the metastasis suppressor function of TEX101 in cancer was disclosed, but the comprehensive investigation of its expression has rarely been reported. In this study, the expression features of TEX101 in normal human organs and seminoma were systematically analyzed. RESULTS: Immunohistochemistry demonstrated intense staining of TEX101 in human testis tissues; however, its expression in 27 other types of normal human organs, including the ovary, was negligible. Higher expression of TEX101 was observed in the spermatocytes and spermatids of the testis, but relatively lower staining was detected in spermatogonia. Western blotting showed a single TEX101 band of 38 kDa in human testis, but it did not correspond to the predicted molecular weight of its mature form at 21 KDa. Furthermore, we examined seminoma tissues by immunohistochemistry and found that none of the 36 samples expressed TEX101. CONCLUSIONS: Our data confirmed TEX101 to be a testis protein that could be related to the maturation process of male germ cells. The lack of TEX101 in seminoma indicated its potential role in tumor progression. This characteristic expression of TEX101 could provide a valuable reference for understanding its biological functions.

  14. Detection of quantitative trait loci causing abnormal spermatogenesis and reduced testis weight in the small testis (Smt) mutant mouse.

    Science.gov (United States)

    Bolor, Hasbaira; Wakasugi, Noboru; Zhao, Wei Dong; Ishikawa, Akira

    2006-04-01

    The small testis (Smt) mutant mouse is characterized by a small testis of one third to one half the size of a normal testis, and its spermatogenesis is mostly arrested at early stages of meiosis, although a small number of spermatocytes at the late prophase of meiosis and a few spermatids can sometimes be seen. We performed quantitative trait locus (QTL) analysis of these spermatogenic traits and testis weight using 221 F2 males obtained from a cross between Smt and MOM (Mus musculus molossinus) mice. At the genome-wide 5% level, we detected two QTLs affecting meiosis on chromosomes 4 and 13, and two QTLs for paired testis weight as a percentage of body weight on chromosomes 4 and X. In addition, we found several QTLs for degenerated germ cells and multinuclear giant cells on chromosomes 4, 7 and 13. Interestingly, for cell degeneration, the QTL on chromosome 13 interacted epistatically with the QTL on chromosome 4. These results reveal polygenic participation in the abnormal spermatogenesis and small testis size in the Smt mutant.

  15. La Sociedad de Autores Españoles (1899-1932

    Directory of Open Access Journals (Sweden)

    Raquel Sánchez García

    2002-01-01

    Full Text Available Durante ia úitima parte dei sigio xix ios autores españoies iniciaron un movimiento asociativo en defensa de sus derechos como profesionales. El proceso culminó en la fundación de la Sociedad de Autores Españoles (precedente de la actual Sociedad General de Autores Españoles. El objetivo principal de la SAE fue conseguir para los autores la administración y gestión de los derectios derivados de sus composiciones musicales y teatrales, lo que tuvo una gran importancia en un momento en que se estaban transformando las formas de ocio en nuestro país. Estas páginas pretenden llevar a cabo un repaso de su organización, sus logros y su evolución desde 1899 hasta 1932.During the last part of xix century, Spanish authors started a movement looking after their rights as professionals in pursuit of assoclations to defend them. The process finished in the foundation of the Sociedad de Autores Españoles (precedent of the SGAE. The principal objective of the SAE was to obtain the right to manage and to negotiate their own works and compositions. This was a very important sucess because of the change of leisure in Spain. In these pages, I will try to study the organization, the achievements and the evolution of the SAE from 1899 to 1932.

  16. Definir al autor. Desde la propiedad intelectual hasta el movimiento derecho y literatura

    Directory of Open Access Journals (Sweden)

    Julio César Padilla Herrera

    2013-12-01

    Full Text Available Comúnmente, analizar la definición de autor es una tarea que en investigación jurídica seaborda desde la propiedad intelectual. En aquella, el autor se asemeja a un propietario dederechos exclusivos y excluyentes, con lo cual se fundamenta una noción cerrada. Pero otraforma –quizás más propicia– de análisis se encuentra en la crítica literaria, situada aquí enla disyunción derecho-literatura. Desde esta última se pretenden hacer evidentes algunoselementos interpretativos que den apertura a la noción unívoca que se halla en la propiedadintelectual. Por lo anterior el presente texto analizará la noción de autor que existe en el derechode autor y en un sector de la crítica literaria con dos propósitos fundaméntales: primerocuestionar el paradigma de autonomía del individuo creador/propietario, y, segundo, aportarcriterios adicionales que permitan superar el significado unívoco de la definición de autor.

  17. Undesended testis: How extensive should the work up be?

    Directory of Open Access Journals (Sweden)

    Shera Altaf

    2010-01-01

    Full Text Available Aim: The aim of this study was to highlight various anomalies associated with undescended testis and to determine how much work up is necessary for this condition. Material and Methods: The study was conducted in the department of Pediatric Surgery SKIMS Srinagar, Kashmir. All patients between 0-14 years of age who attended out patient department (OPD from January 2002 to December 2003 with maldescent of testes were included in the study. Detailed relevant history and physical examination findings were recorded in all the cases. Baseline investigations were performed along with ultrasonography of the abdomen. In relevant cases other investigations like intravenous urography, micturating cystourethrography, CT scan and laparoscopy were performed as and when indicated. Results: A total of 250 cases of undescended testis were registered during this period. Maximum number of cases were in the age group of 5-10 years. In 130 (52% cases the right testis was undescended while 75 (30% had left sided undescended testis and 45 (18% had bilateral undescended testis. Maldescended testis comprised 11% of the admissions. The majority of cases were having gestational age of 37 weeks or more. The associated anomalies picked up on investigations included duplication of upper urinary tract (3.2%, hydronephrosis and polycystic kidney (0.8% each, horseshoe kidney, ectopic kidney, crossed renal ectopia (0.4% each Posterior urethral valves, Prune belly syndrome (0.4% and spina bifida (0.4%. On detailed clinical examination of genitalia several abnormalities were picked which included hydrocele, hypospadias, hernia, chordee, micropenis and ambiguous genitalia. Conclusion: We recommend ultrasonography to be done in all cases of undescended testis in addition to a thorough history and physical examination. Intravenous pyelography, micturating cystourethrogram, CT scan and other investigations should be performed selectively based on history, physical examination or

  18. Compedios: Sobre los Autores de los Archivos Científicos

    Directory of Open Access Journals (Sweden)

    Juan Mendoza Vega

    1990-12-01

    Full Text Available

    Académico Juan Mendoza Vega. En el competitivo mundo moderno de la ciencia, la publicación de artículos científicos es actividad no sólo importante sino de las más estimadas; con ella se transmiten a la comunidad científica los resultados de las investigaciones, se dan a conocer las reflexiones, comentarios o desarrollos sobre esos temas y se presentan perspectivas para el futuro; pero también sirven los artículos científicos como renglones fundamentales en el currículo de los profesionales, que en esa forma pueden mostrar presuntamente su capacidad de trabajo, su creatividad y productividad original. El ser autor de artículos científicos se ha tornado logro importante, hasta el punto de que en ciertos ambientes se tiene como axioma la frase “Publicar o Morir”, por supuesto en el sentido académico.

    Esta sitt1ación ha permitido el surgimiento de vicios que se empezaron a notar hace ya más de 10 años, pero cuya ocurrencia parece incrementar, si juzgamos por el número de publicaciones que analizan esos fenómenos en los años más recientes.

    Especialmente importante resulta el artículo en que el doctor Gustavo A. Silva, funcionario de la Organización Panamericana de la Salud (OPS analiza los problemas de la “Autoría Múltiple” y la “Autoría Injustificada”, y que fue publicado en la edición de febrero de 1990 por el Boletín de la Oficina Sanitaria Panamericana. De acuerdo con el doctor Silva, la costumbre de publicar artículos con la firma de varios autores aumentó notoriamente en el decenio 1979-1988; en efecto, entre 1959 y 1968, el 62.77% de 795 artículos tenían un solo autor y el 6.7 más de cinco autores, pero la proporción cambió a 30.8 con un solo autor, 45.9 entre dos y cuatro autores y 23.2 con cinco autores o más, en el último decenio arriba aludido.

    Por supuesto, en muchos casos se justifica la presencia de múltiples autores al frente de un trabajo especialmente complejo o

  19. Finalmente, um novo texto de autores brasileiros sobre teorias de marketing

    Directory of Open Access Journals (Sweden)

    José Rafael Motta Neto

    2007-12-01

    Full Text Available  Até recentemente, o ensino de marketing nas universidades e faculdades brasileiras tinha o suporte bibliográfico de autores clássicos da literatura da área. Pontificavam nomes como Philip Kotler, o mais tradicional dos autores de marketing, com suas obras em português nos servindo desde os anos 60, até obras mais recentes como a de Gilbert A. Churchill Jr e J. Paul Peter, passando por consagrados autores nacionais como Marcos Cobra e Alexandre Las Casas. Obviamente estamos falando de obras que fazem referência à teoria do marketing, abordando integralmente o conteúdo que permite ao leitor entender todos os conceitos desta área, numa seqüência didaticamente adequada, além de facilitar, para o professor, a transmissão da matéria, como na disciplina de Administração Mercadológica.

  20. Tehnikahuviline juht ootab töötajalt ausust / Andres Haamer ; interv. Urve Vilk

    Index Scriptorium Estoniae

    Haamer, Andres, 1942-

    2008-01-01

    Overall Eesti nõukogu esimees Andres Haamer vastab oma lapsepõlve, haridusteed, karjääri, AS-i Overalli asutamist, oma tööülesandeid ning ühiskondlikus elus osalemist puudutavatele küsimustele. Kommenteerib Valdo Kalm. Lisa: Andres Haamer; Edu võtmed

  1. Thyroid Hormone Role and Economy in the Developing Testis.

    Science.gov (United States)

    Hernandez, Arturo

    2018-01-01

    Thyroid hormones (TH) exhibit pleiotropic regulatory effects on growth, development, and metabolism, and it is becoming increasingly apparent that the developing testis is an important target for them. Testicular development is highly dependent on TH status. Both hypo- and hyperthyroidism affect testis size and the proliferation and differentiation of Sertoli, Leydig, and germ cells, with consequences for steroidogenesis, spermatogenesis, and male fertility. These observations suggest that an appropriate content of TH and by implication TH action in the testis, whether the result of systemic hormonal levels or regulatory mechanisms at the local level, is critical for normal testicular and reproductive function. The available evidence indicates the presence in the developing testis of a number of transporters, deiodinases and receptors that could play a role in the timely delivery of TH action on testicular cells. These include the thyroid hormone receptor alpha (THRA), the MCT8 transporter, the TH-activating deiodinase DIO2, and the TH-inactivating deiodinase DIO3, all of which appear to modulate testicular TH economy and testis outcomes. © 2018 Elsevier Inc. All rights reserved.

  2. Globaliseerumine : oht või võimalus? / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2007-01-01

    Globaliseerumise ja võrgustumise muutumine võimaluseks või ohuks sõltub konkreetse riigi majanduse ja tööturu kohanemisvõimest. Globaalsete finantsvoogude kirjeldus, kapitali ja Eestisse tulevate rahavoogude analüüs ning hinnang Eesti tööturu paindlikkusele ja ettevõtjate innovatiivsusele. Graafikud: Otse- ja portfelliinvesteeringute ning laenude sissevool Eestisse 1992-2006; Diagramm: Eesti tööjõuturg sammub Ameerika jälgedes. Vt. samas: Andres Saarniit. Raha ei ole kuhugi kadunud

  3. As marcas de (intersubjetividade nas tiras de André Dahmer: uma análise enunciativa

    Directory of Open Access Journals (Sweden)

    Lucy Peres Farias

    2017-07-01

    Full Text Available Dos estudos postulados por Benveniste (1956 compreendemos que desde que nos declaramos locutores, nos apropriando da língua para enunciar, automaticamente implantamos o outro diante de nós, em maior ou menor grau de presença. Este artigo objetiva analisar tirinhas do autor André Dahmer na perspectiva do sujeito e intersubjetividade estudada por Benveniste (1956, explicando de que maneira se dá essa intersubjetividade, explicando os efeitos de sentido que são construídos a partir de marcas de sujeito encontradas. Para tanto, as categorias utilizadas serão, principalmente, as noções de pessoa e não pessoa, de Benveniste (1956, operações de localização, de Culioli (1982, apud CAMPOS, 1994, 1997 e modalidades, segundo Neves (2012. Os resultados obtidos a partir da análise mostraram a ocorrência de algumas marcas mais frequentes que outras, e pudemos perceber que a construção de sentidos de humor e crítica está imbricada às escolhas dessas categorias e marcas nos enunciados, marcas essas importantes para a relação de (intersubjetividade na perspectiva Culioliana.

  4. Tzfp represses the androgen receptor in mouse testis.

    Science.gov (United States)

    Furu, Kari; Klungland, Arne

    2013-01-01

    The testis zinc finger protein (Tzfp), also known as Repressor of GATA, belongs to the BTB/POZ zinc finger family of transcription factors and is thought to play a role in spermatogenesis due to its remarkably high expression in testis. Despite many attempts to find the in vivo role of the protein, the molecular function is still largely unknown. Here, we address this issue using a novel mouse model with a disrupted Tzfp gene. Homozygous Tzfp null mice are born at reduced frequency but appear viable and fertile. Sertoli cells in testes lacking Tzfp display an increase in Androgen Receptor (AR) signaling, and several genes in the testis, including Gata1, Aie1 and Fanc, show increased expression. Our results indicate that Tzfp function as a transcriptional regulator and that loss of the protein leads to alterations in AR signaling and reduced number of apoptotic cells in the testicular tubules.

  5. Tzfp represses the androgen receptor in mouse testis.

    Directory of Open Access Journals (Sweden)

    Kari Furu

    Full Text Available The testis zinc finger protein (Tzfp, also known as Repressor of GATA, belongs to the BTB/POZ zinc finger family of transcription factors and is thought to play a role in spermatogenesis due to its remarkably high expression in testis. Despite many attempts to find the in vivo role of the protein, the molecular function is still largely unknown. Here, we address this issue using a novel mouse model with a disrupted Tzfp gene. Homozygous Tzfp null mice are born at reduced frequency but appear viable and fertile. Sertoli cells in testes lacking Tzfp display an increase in Androgen Receptor (AR signaling, and several genes in the testis, including Gata1, Aie1 and Fanc, show increased expression. Our results indicate that Tzfp function as a transcriptional regulator and that loss of the protein leads to alterations in AR signaling and reduced number of apoptotic cells in the testicular tubules.

  6. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis

    Directory of Open Access Journals (Sweden)

    Tony DeFalco

    2015-08-01

    Full Text Available The testis produces sperm throughout the male reproductive lifespan by balancing self-renewal and differentiation of spermatogonial stem cells (SSCs. Part of the SSC niche is thought to lie outside the seminiferous tubules of the testis; however, specific interstitial components of the niche that regulate spermatogonial divisions and differentiation remain undefined. We identified distinct populations of testicular macrophages, one of which lies on the surface of seminiferous tubules, in close apposition to areas of tubules enriched for undifferentiated spermatogonia. These macrophages express spermatogonial proliferation- and differentiation-inducing factors, such as colony-stimulating factor 1 (CSF1 and enzymes involved in retinoic acid (RA biosynthesis. We show that transient depletion of macrophages leads to a disruption in spermatogonial differentiation. These findings reveal an unexpected role for macrophages in the spermatogonial niche in the testis and raise the possibility that macrophages play previously unappreciated roles in stem/progenitor cell regulation in other tissues.

  7. Un recorrido sobre el autor: su problematización en Gadamer, Jauss y Eco

    Directory of Open Access Journals (Sweden)

    Mariana Patricia Busso

    2012-06-01

    Full Text Available En el presente artículo intentaremos rastrear el concepto de autor en el trabajo de Hans-Georg Gadamer, Hans Robert Jauss y Umberto Eco, pensadores clave que desde la hermenéutica y el estructuralismo han abordado la problemática tríada autor – obra – lector en la segunda mitad del siglo XX. La importancia de la puesta en diálogo de estos enfoques está dada por la vigencia de la problemática de la autoría –o de la desaparición de la misma- en un contexto donde en el pensamiento social cobra vital importancia el lugar del lenguaje como capaz de crear tanto al sujeto como a la realidad por él interpretada. Los pensadores que hemos seleccionado, en este sentido, no presentan miradas homogéneas sobre la cuestión dada sus procedencias epistemológicas diversas, aunque se encuentran en un cierto modo mancomunados por el intento de otorgar un nuevo status al autor, lector y texto en relación al funcionamiento del lenguaje.

  8. Initial Development of an Electronic Testis Rigidity Tester

    Directory of Open Access Journals (Sweden)

    Petros Mirilas

    2011-01-01

    Full Text Available We aimed to develop our previously presented mechanical device, the Testis Rigidity Tester (TRT, into an electronic system (Electronic Testis Rigidity Tester, ETRT by applying tactile imaging, which has been used successfully with other solid organs. A measuring device, located at the front end of the ETRT incorporates a tactile sensor comprising an array of microsensors. By application of a predetermined deformation of 2 mm, increased pressure alters linearly the resistance of each microsensor, producing changes of voltage. These signals were amplified, filtered, and digitized, and then processed by an electronic collector system, which presented them as a color-filled contour plot of the area of the testis coming into contact with the sensor. Testis models of different rigidity served for initial evaluation of ETRT; their evacuated central spaces contained different, increasing glue masses. An independent method of rigidity measurement, using an electric weight scale and a micrometer, showed that the more the glue injected, the greater the force needed for a 2-mm deformation. In a preliminary test, a single sensor connected to a multimeter showed similar force measurement for the same deformation in these phantoms. For each of the testis models compressed in the same manner, the ETRT system offered a map of pressures, represented by a color scale within the contour plot of the contact area with the sensor. ETRT found certain differences in rigidity between models that had escaped detection by a blind observer. ETRT is easy to use and provides a color-coded “insight“ of the testis internal structure. After experimental testing, it could be valuable in intraoperative evaluation of testes, so that the surgeon can decide about orchectomy or orcheopexy.

  9. Aspectos Contábeis dos Créditos de Carbono: Estudo com Autores Nacionais

    Directory of Open Access Journals (Sweden)

    Vanderlei dos Santos

    2013-12-01

    Full Text Available O estudo objetiva verificar o entendimento de autores nacionais no que concerne à classificação, forma de reconhecimento e mensuração das operações com créditos de carbono. O estudo de natureza descritiva foi realizado em 2011, por meio de pesquisa de levantamento ou survey, com abordagem quantitativa. Utilizou-se o questionário como instrumento de coleta de dados, que foi enviado a 23 pesquisadores nacionais que possuem publicação de artigos relacionados à contabilização dos créditos de carbono em periódicos nacionais. Obtiveram-se nove respostas, que constituíram numa amostra por acessibilidade. Para a análise dos dados obtidos optou-se pelo uso da técnica da entropia informacional. Os resultados do estudo mostraram que, quanto à classificação dos créditos de carbono, há um entendimento maior entre os autores de que se trata de ativos especiais e que não podem ser considerados como commodity. Observou-se que não há consenso entre os autores em classificar os créditos de carbono como ativo intangível ou estoque. Deste modo, concluiu-se que ainda existem divergências no entendimento dos autores analisados no que concerne aos aspectos contábeis das operações com créditos de carbono. O artigo contribui principalmente na medida em que busca consolidar diferentes opiniões de autores, que pesquisam sobre a temática, demonstrando aspectos convergentes e divergentes, além de enfatizar lacunas para desenvolver pesquisas futuras.

  10. La red de co-autores en la Bibliometría mexicana

    Directory of Open Access Journals (Sweden)

    Cristina Restrepo-Arango

    2018-01-01

    Full Text Available Se analiza la red de coautorías existentes en las publicaciones sobre las metrías (bibliometría, informetría, cienciometría, patentometría, etc. en México, desde la década de los 70s hasta diciembre de 2012. Se utilizó el análisis de redes sociales a través del software Ucinet 6.0 y Netdraw. Los análisis muestran una red altamente centralizada. La densidad global de la red indica una red de baja densidad comunicacional que hace una utilización efectiva de una quinta parte de los vínculos reales sobre el total de vínculos posibles entre todos los autores de la red. El grado de centralidad identifica once autores como los componentes estructurales de la red de bibliometría mexicana. Los coeficientes del grado de cercanía indican que tanto la lejanía como la cercanía son homogéneas. En relación con el grado de intermediación se encontró que no existe una red ampliamente extendida sino la dominancia de un pequeño grupo de tres autores. La distancia geodésica identificó un único autor bien conectado a otros autores también muy bien posicionados en la red. No se identificaron cliques ni n-cliques en la red de coautoría de la bibliometría mexicana.

  11. Gene expression during testis development in Duroc boars

    DEFF Research Database (Denmark)

    Lervik, Siri; Kristoffersen, Anja Bråthen; Conley, Lene

    2015-01-01

    . Nine clusters of genes with significant differential expression over time and 49 functional charts were found in the analysed testis samples. Prominent pathways in the prepubertal testis were associated with tissue renewal, cell respiration and increased endocytocis. E-cadherines may be associated...... with the onset of pubertal development. With elevated steroidogenesis (weeks 16 to 27), there was an increase in the expression of genes in the MAPK pathway, STAR and its analogue STARD6. A pubertal shift in genes coding for cellular cholesterol transport was observed. Increased expression of meiotic pathways...

  12. Sex cord-gonadal stromal tumor of the rete testis.

    Science.gov (United States)

    Sajadi, Kamran P; Dalton, Rory R; Brown, James A

    2009-01-01

    A 34-year-old tetraplegic patient with suppurative epididymitis was found on follow-up examination and ultrasonography to have a testicular mass. The radical orchiectomy specimen contained an undifferentiated spindled sex cord-stromal tumor arising in the rete testis. Testicular sex cord-stromal tumors are far less common than germ cell neoplasms and are usually benign. The close relationship between sex cords and ductules of the rete testis during development provides the opportunity for these uncommon tumors to arise anatomically within the rete tesis. This undifferentiated sex cord-stromal tumor, occurring in a previously unreported location, is an example of an unusual lesion mimicking an intratesticular malignant neoplasm.

  13. Surgical treatment and follow up on undescended testis

    DEFF Research Database (Denmark)

    Thorup, Jørgen Mogens; Cortes, D.

    2009-01-01

    With skill and ability to control a variety of operative techniques, undescended testes can be placed in the scrotum with 90% success rate in palpable testes and 85% in abdominal testes. Long term results are related also to the variability of the disease. A hypothesis that in cryptorchid testes...... number at birth in some cryptorchid testes and Intratubular Germ Cell Neoplasia seen in early childhood. The hypothesis that the abnormal location of the testis exposes the testis to infertility and malignant transformation is supported by the findings of early treatment lowering the risk of both...

  14. Valitsus ei täida oma lubadusi / Andres Varik

    Index Scriptorium Estoniae

    Varik, Andres, 1952-

    2000-01-01

    2001. aasta riigieelarve eelnõu kriitika. Tabel: Põllumajanduse otsetoetused Eestis 1997-2001. Autor: ERL. Parlamendisaadik. Ilmunud ka: Nädaline 31. okt. lk. 5; Valgamaalane 26. okt., Pärnu Postimees 31. okt.; Hiiu Leht 31. okt. lk. 2; Meie Maa 31. okt. lk. 6

  15. Kolm kuningriiki näitasid traagelniite / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2011-01-01

    NO99 teatris 7. oktoobrini etenduvast lavastusest "Three Kingdoms" ("Kolm kuningriiki"). Autor Simon Stephens, lavastaja Sebastian Nübling, kunstnik Ene-Liis Semper. Mängivad eesti, saksa ja inglise näitlejad. Oktoobris ja novembris mängitakse Münchner Kammerspieles, märtsis 2012 Londonis

  16. Baltic commerce : not yet on the Internet / Andres Agasild

    Index Scriptorium Estoniae

    Agasild, Andres, 1976-

    2005-01-01

    Vaatamata Eesti erakordselt kõrgele Interneti kasutamise tasemele on elektroonilise kaubanduse areng aeglane. Autor leiab selle peamiseks seletuseks olevat asjaolu, et 82% Interneti kasutajatest on alla 20-aastased õpilased ja üliõpilased, kelle ostujõud on madal. Lisa: MarkIT

  17. Estonia näitas uut logo / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2004-01-01

    Ooperiteatri uue logo autor on Kristjan Kirsfeldt. Liis Kolle lavastab G. Rossini ooperi "Sinjoor Bruschino ehk Poeg juhuse tahtel", kunstnikud Liina Keevallik ja Reili Evart. 2. juunil Rahvusooperis etendunud rahvusooperi näiteringi "Welcome to Estonia" Neeme Kuninga kirjutatud ja lavastatud muusikalist "Minu veetlev Eedi".

  18. Sofi Oksase luule muutus Vanemuises teatrireaalsuseks / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    18. septembril Vanemuise teatri väikeses majas esietendunud lavastusest "Puhastus", autor Sofi Oksanen, lavastaja Liisa Smith. Vaatluse all on sündmused Eesti lähiminevikust (1936-1992). "Puhastust" mängitakse Helsingis Kansallisteatteri laval kaks korda jaanuaris 2011

  19. The genusGuenthera Andr. in Bess. (Brassicaceae, Brassiceae

    Directory of Open Access Journals (Sweden)

    Gómez-Campo, César

    2003-12-01

    Full Text Available A group of nine species -now included in Brassica— differ from all the other species in several characters, mainly in the stylar portion of their pistils always without seed primordia. Also in their branched subterranean stem (caudex with several leaf rosettes, their leaves entire to deeply pinnatifid but never pinnatisect, their shallowly notched cotyledons and their flattened, elliptic or ovoid seed contour. It is suggested to include these species under the generic denomination Guenthera Andr, in Bess. New ñames for the species and subspecies are provided, as well as a determination key for the species.Un grupo de nueve especies actualmente incluidas en Brassica difiere de todas las demás por varios caracteres, sobre todo por la porción estilar de sus pistilos, que siempre carece de primordios seminales. Además, por su tallo subterráneo ramificado, que forma un cáudex con varias rosetas; sus hojas de enteras hasta profundamente pinnatífidas, pero nunca pinnatisectas; sus cotiledones solo muy ligeramente escotados, y sus semillas, que tienden a ser elipsoidales o aplanadas. Se propone agruparlas todas bajo la denominación genérica Guenthera Andr, in Bess. Se detallan los nuevos nombres para las especies y Subespecies y se añade una clave para diferenciar las especies.

  20. Pomeranchuk Prize awarded to André Martin

    CERN Multimedia

    Jordan Juras

    2010-01-01

    Professor André Martin has been awarded the I.Ya.Pomeranchuk Prize 2010, alongside Professor Valentine Zakharov.   André Martin, CERN theorist, pictured at the ceremony held in honour of his 80th birthday (August 2009). Established by the Institute of Theoretical and Experimental Physics (ITEP) in memory of an outstanding scientist Isaak Yakovlevich Pomeranchuk, the prize is awarded for the study of analytic properties of the scattering amplitude; which lead to the Froissart—Martin bound on the cross section growth with energy. The prize comes as a great honor for Martin, who was in fact a good friend of Mr. Pomeranchuk, "I am surprised and delighted to learn that I will be receiving the 2010 Pomeranchuk Prize. I was an admirer of Pomeranchuk and we shared a great friendship. I met with him for the last time in Erevan (Armenia) in 1965. As a good-bye, he told me, 'Analyticity exists'. This is precisely what I proved to earn the prize"....

  1. File list: NoD.Gon.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Gon.50.AllAg.Testis mm9 No description Gonad Testis ERX144521,ERX221032,ERX0968...144545,ERX144532 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Gon.50.AllAg.Testis.bed ...

  2. File list: InP.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.10.AllAg.Testis mm9 Input control Gonad Testis SRX349389,SRX1011025,SRX1183...X838550,SRX118389 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Gon.10.AllAg.Testis.bed ...

  3. File list: His.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Gon.10.AllAg.Testis mm9 Histone Gonad Testis SRX118394,SRX803711,SRX803710,SRX0...SRX671899,SRX185788,SRX185866 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Gon.10.AllAg.Testis.bed ...

  4. File list: NoD.Gon.05.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Gon.05.AllAg.Testis mm9 No description Gonad Testis ERX144544,ERX144521,ERX2210...144545,ERX144532 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Gon.05.AllAg.Testis.bed ...

  5. File list: His.Gon.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Gon.50.AllAg.Testis mm9 Histone Gonad Testis SRX803711,SRX118394,SRX803710,SRX8...SRX671900,SRX671899,SRX185788 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Gon.50.AllAg.Testis.bed ...

  6. File list: InP.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.10.AllAg.Testis hg19 Input control Gonad Testis SRX663452,SRX663439,SRX6634...45,SRX663442 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Gon.10.AllAg.Testis.bed ...

  7. File list: His.Adl.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Adl.10.AllAg.Testis dm3 Histone Adult Testis SRX017854,SRX017856,SRX390502,SRX3...90501 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Adl.10.AllAg.Testis.bed ...

  8. File list: ALL.Gon.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Gon.20.AllAg.Testis hg19 All antigens Gonad Testis ERX096851,SRX663448,SRX12124...444,SRX663451,SRX663439,SRX663438,SRX663445,SRX663442 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Gon.20.AllAg.Testis.bed ...

  9. File list: Pol.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Gon.10.AllAg.Testis mm9 RNA polymerase Gonad Testis SRX349391,SRX112975,SRX1437...96,SRX237511,SRX237510,SRX244355 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.Gon.10.AllAg.Testis.bed ...

  10. File list: InP.Gon.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.20.AllAg.Testis mm9 Input control Gonad Testis SRX112534,SRX349389,SRX02744...X118388,SRX118389 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Gon.20.AllAg.Testis.bed ...

  11. File list: InP.Gon.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.50.AllAg.Testis hg19 Input control Gonad Testis SRX663452,SRX663439,SRX6634...45,SRX663442 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Gon.50.AllAg.Testis.bed ...

  12. File list: Oth.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Gon.10.AllAg.Testis hg19 TFs and others Gonad Testis SRX663450,SRX663441,SRX663...438,SRX663444,SRX663451 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Gon.10.AllAg.Testis.bed ...

  13. File list: Oth.Gon.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Gon.50.AllAg.Testis hg19 TFs and others Gonad Testis SRX663441,SRX663451,SRX663...450,SRX663444,SRX663438 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Gon.50.AllAg.Testis.bed ...

  14. File list: His.Adl.05.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Adl.05.AllAg.Testis dm3 Histone Adult Testis SRX017854,SRX017856,SRX390501,SRX3...90502 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Adl.05.AllAg.Testis.bed ...

  15. File list: Pol.Gon.05.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Gon.05.AllAg.Testis mm9 RNA polymerase Gonad Testis SRX349391,SRX112975,SRX1437...96,SRX237511,SRX244355,SRX237510 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.Gon.05.AllAg.Testis.bed ...

  16. File list: ALL.Adl.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Adl.20.AllAg.Testis dm3 All antigens Adult Testis SRX017857,SRX390502,SRX390501...,SRX017856,SRX390503,SRX017854 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Adl.20.AllAg.Testis.bed ...

  17. File list: ALL.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Gon.10.AllAg.Testis mm9 All antigens Gonad Testis SRX118383,SRX112538,SRX118394...ERX144545,ERX144553,SRX118378,SRX118389,SRX112536,ERX144532,SRX112537 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Gon.10.AllAg.Testis.bed ...

  18. File list: NoD.Gon.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Gon.50.AllAg.Testis hg19 No description Gonad Testis ERX096851,ERX161924,ERX096...870,ERX096849,ERX096875,ERX096874,ERX096842 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.Gon.50.AllAg.Testis.bed ...

  19. File list: ALL.Adl.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Adl.50.AllAg.Testis dm3 All antigens Adult Testis SRX390502,SRX390501,SRX390503...,SRX017856,SRX017854 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Adl.50.AllAg.Testis.bed ...

  20. File list: ALL.Gon.05.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Gon.05.AllAg.Testis hg19 All antigens Gonad Testis ERX096851,ERX096875,SRX66344...441,SRX663438,SRX663451,SRX663439,SRX663445,SRX663442 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Gon.05.AllAg.Testis.bed ...

  1. File list: NoD.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Gon.10.AllAg.Testis mm9 No description Gonad Testis ERX144544,ERX144521,ERX2210...144553,ERX144532 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Gon.10.AllAg.Testis.bed ...

  2. File list: InP.Gon.05.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.05.AllAg.Testis mm9 Input control Gonad Testis SRX112977,SRX349389,SRX10110...X803713,SRX838550 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Gon.05.AllAg.Testis.bed ...

  3. File list: InP.Gon.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.20.AllAg.Testis hg19 Input control Gonad Testis SRX663452,SRX663439,SRX6634...45,SRX663442 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Gon.20.AllAg.Testis.bed ...

  4. File list: NoD.Gon.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Gon.20.AllAg.Testis hg19 No description Gonad Testis ERX096851,ERX161924,ERX096...849,ERX096874,ERX096842,ERX096870,ERX096875 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.Gon.20.AllAg.Testis.bed ...

  5. File list: ALL.Adl.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Adl.10.AllAg.Testis dm3 All antigens Adult Testis SRX017857,SRX017854,SRX017856...,SRX390502,SRX390501,SRX390503 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Adl.10.AllAg.Testis.bed ...

  6. File list: Pol.Gon.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Gon.20.AllAg.Testis mm9 RNA polymerase Gonad Testis SRX349391,SRX112975,SRX1437...96,SRX237511,SRX237510,SRX244355 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.Gon.20.AllAg.Testis.bed ...

  7. File list: His.Adl.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Adl.20.AllAg.Testis dm3 Histone Adult Testis SRX390502,SRX390501,SRX017856,SRX0...17854 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Adl.20.AllAg.Testis.bed ...

  8. File list: InP.Gon.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.50.AllAg.Testis mm9 Input control Gonad Testis SRX112534,SRX349389,SRX02744...X112541,SRX118389 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Gon.50.AllAg.Testis.bed ...

  9. File list: NoD.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Gon.10.AllAg.Testis hg19 No description Gonad Testis ERX096851,ERX096870,ERX161...924,ERX096849,ERX096875,ERX096874,ERX096842 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.Gon.10.AllAg.Testis.bed ...

  10. File list: His.Gon.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Gon.20.AllAg.Testis mm9 Histone Gonad Testis SRX118394,SRX803711,SRX803710,SRX3...SRX112973,SRX185799,SRX185788 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Gon.20.AllAg.Testis.bed ...

  11. File list: His.Adl.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Adl.50.AllAg.Testis dm3 Histone Adult Testis SRX390502,SRX390501,SRX017856,SRX0...17854 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Adl.50.AllAg.Testis.bed ...

  12. File list: ALL.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Gon.10.AllAg.Testis hg19 All antigens Gonad Testis ERX096851,SRX663448,ERX09687...438,SRX663444,SRX663451,SRX663439,SRX663445,SRX663442 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Gon.10.AllAg.Testis.bed ...

  13. File list: ALL.Gon.50.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Gon.50.AllAg.Testis hg19 All antigens Gonad Testis ERX096851,SRX663448,SRX12124...439,ERX096875,SRX663445,SRX663442,ERX096874,ERX096842 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Gon.50.AllAg.Testis.bed ...

  14. File list: ALL.Gon.20.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Gon.20.AllAg.Testis mm9 All antigens Gonad Testis SRX118394,SRX349391,SRX803711...SRX112541,SRX118388,SRX118389,ERX144545,ERX144532,SRX112536,SRX112537 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Gon.20.AllAg.Testis.bed ...

  15. File list: InP.Gon.05.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.05.AllAg.Testis hg19 Input control Gonad Testis SRX663452,SRX663439,SRX6634...45,SRX663442 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Gon.05.AllAg.Testis.bed ...

  16. File list: ALL.Adl.05.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Adl.05.AllAg.Testis dm3 All antigens Adult Testis SRX017854,SRX017856,SRX017857...,SRX390503,SRX390501,SRX390502 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Adl.05.AllAg.Testis.bed ...

  17. File list: ALL.Gon.05.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Gon.05.AllAg.Testis mm9 All antigens Gonad Testis SRX803711,SRX118383,SRX118371...ERX144553,SRX803713,SRX838550,ERX144545,ERX144532,SRX112536,SRX112537 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Gon.05.AllAg.Testis.bed ...

  18. File list: ALL.Emb.20.AllAg.Embryonic_testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Emb.20.AllAg.Embryonic_testis mm9 All antigens Embryo Embryonic testis SRX14917...57137,SRX1156635,SRX149168,SRX149172,SRX1175150,SRX149166,SRX149170,SRX1175149 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Emb.20.AllAg.Embryonic_testis.bed ...

  19. File list: DNS.Emb.20.AllAg.Embryonic_testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Emb.20.AllAg.Embryonic_testis mm9 DNase-seq Embryo Embryonic testis SRX1156635 ...http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.Emb.20.AllAg.Embryonic_testis.bed ...

  20. File list: ALL.Emb.10.AllAg.Embryonic_testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Emb.10.AllAg.Embryonic_testis mm9 All antigens Embryo Embryonic testis SRX14917...9169,SRX149166,SRX1175147,SRX957137,SRX1175148,SRX149170,SRX1175150,SRX1175149 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Emb.10.AllAg.Embryonic_testis.bed ...

  1. File list: InP.Emb.10.AllAg.Embryonic_testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Emb.10.AllAg.Embryonic_testis mm9 Input control Embryo Embryonic testis SRX1491...74,SRX149168,SRX957136,SRX149172,SRX149166,SRX1175150,SRX1175149 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Emb.10.AllAg.Embryonic_testis.bed ...

  2. File list: InP.Emb.50.AllAg.Embryonic_testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Emb.50.AllAg.Embryonic_testis mm9 Input control Embryo Embryonic testis SRX1491...74,SRX149168,SRX149172,SRX1175150,SRX149166,SRX957136,SRX1175149 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Emb.50.AllAg.Embryonic_testis.bed ...

  3. Formalidades del derecho de autor en la era de internet: filtros de protección o facilitadores de licenciamiento

    NARCIS (Netherlands)

    van Gompel, S.

    2016-01-01

    El autor se refiere a los objetivos que inspirarían la reinstauración de formalidades de derechos de autor, señalando dos objetivos específicos, el de facilitar la adquisición de derechos de autor y el de mejorar el flujo de información al aumentar el dominio público. Ambos ayudarían a alcanzar el

  4. Comparative morphophysiological evaluation of the testis of adult ...

    African Journals Online (AJOL)

    olayemitoyin

    Wistar rats fed low protein-energy diet and dosed with aqueous extracts ... extracts of C. australis seed and stem, 300mg/kg body weight/day for seven days, on the testis of the adult Wistar rat ..... Modern Study of Traditional Chinese Medicine,.

  5. Sox9 induces testis development in XX transgenic mice

    NARCIS (Netherlands)

    Vidal, V. P.; Chaboissier, M. C.; de rooij, D. G.; Schedl, A.

    2001-01-01

    Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the

  6. Testicular development and relationship between body weight, testis ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-03-20

    Mar 20, 2009 ... reports seem to indicate that boars with higher body and testis weight may ... in terms of loss of animals of good genetic standing may be of no practical ... weekly intervals until they reached 36 weeks of age. The ... Training of boars and semen collection. All in situ ..... on semen composition in the boar. Can.

  7. Terminology and details of the diagnostic process for testis cancer.

    LENUS (Irish Health Repository)

    Connolly, Stephen S

    2011-03-01

    We examined the process and causes of diagnostic delay, defined as the interval from symptom onset to diagnosis, for testis (germ cell) cancer and the change with time. Diagnostic delay influences disease burden and may be subdivided into symptomatic interval, defined as symptom onset to first presentation, and diagnostic interval, defined as first presentation to diagnosis.

  8. Gonadotropin Regulation of Retinoic Acid Activity in the Testis

    Directory of Open Access Journals (Sweden)

    Seyedmehdi Nourashrafeddin

    2018-02-01

    Full Text Available Initiation of spermatogenesis in primates is triggered at puberty by an increase in gonadotropins; i.e., follicle-stimulating hormone (FSH and luteinizing hormone (LH. Prior to puberty, testis of the monkey contains only undifferentiated germ cells. However, sermatogonial differentiation and spermatogenesis may be initiated prior to puberty after stimulation with exogenous LH and FSH. Retinoic acid (RA signaling is considered to be a major component that drives spermatogonial differentiation. We were interested in evaluating the relative role of LH and FSH, either alone or in combination, in regulating the retinoic acid signaling in monkey testis. Sixteen juvenile male rhesus monkeys (Macaca mulatta were infused with intermittent recombinant single chain human LH (schLH or recombinant human FSH (rhFSH or a combination of both for 11 days. We then analyzed the expression of the several putative RA signaling pathway related genes; i.e. RDH10, RDH11, ALDH1A1, ALDH1A2, CYP26B1, CRABP1, CRABP2, STRA6, STRA8 in the testis after 11 days of stimulation with vehicle, LH, FSH and combination LH/FSH using quantitative real-time PCR (qPCR. The qPCR results analysis showed that administration of gonadotropins affected a significant change in expression of some RA signaling related genes in the monkey testis. The gonadotropins, either alone or in combination dramatically increased expression of CRABP2 (p≤0.001, whereas there was a decrease in ALDH1A2 expression (p≤0.001. Moreover, combined gonadotropin treatment led to the significant decrease in CRABP1 expression (p≤0.05. These findings are the first evidence that the activity of retinoic acid signaling in the monkey testis is regulated through gonadotropins (LH/FSH levels.

  9. Indices de Munibe (Antropologia-Arkeologia. Autores y Materias (Años 1949-1999

    Directory of Open Access Journals (Sweden)

    Koro Mariezkurrena

    1999-01-01

    Full Text Available En 1973, al cumplir la revista Munibe 25 años, J. ELOSEGUI IRAZUSTA publicó los índices de todos los trabajos publicados en la misma hasta la fecha. Posteriormente hemos continuado esta labor publicando cada cinco años índices de ese período. Los dos primeros quiquenios recogen los índices de todos los temas que publicaba la revista, a saber, Geología, Botánica, Zoología, Antropología y Arqueología. Al dividirse en 1985 la revista en dos, Ciencias naturales por un lado y Antropologia-Arqueología por otro, a partir de los índices del quinquenio 1983-1988, venimos recogiendo solamente los artículos referentes a estos últimos temas. En los presentes índices recogemos todos los artículos, notas y recensiones referentes a Antropología y Arqueología publicados en los 50 años de vida de la revista, entresacando los que aparecieron cuando la revista era única y recogiendo todos los aparecidos después de la división. Estos índices los presentamos en tres apartados : Indice alfabético de autores, ordenados dentro de cada autor por años Indice por años de revista, ordenados los autores alfabéticamente Indice por temas.

  10. O DESAPARECIMENTO DO AUTOR NAS TRAMAS DA LITERATURA DIGITAL: UMA REFLEXÃO FOUCAULTIANA

    Directory of Open Access Journals (Sweden)

    Edgar Roberto Kirchof

    2009-08-01

    Full Text Available O presente artigo aborda a questão da autoria na literatura digital sob a perspectiva do filósofo francês Michel Foucault. Inicialmente, apresenta-se o estado recente da discussão a partir de duas posições antagônicas: o desaparecimento do autor na estrutura hipertextual, de um lado, e o fortalecimento de sua soberania, de outro lado. Após uma breve sistematização do que tem sido considerado literatura digital pela crítica contemporânea, apresenta-se uma síntese da noção foucaultiana sobre o problema da autoria, a partir da qual passa-se à argumentação, inspirada no pensamento de Foucault, segundo a qual o autor do hipertexto não desaparece enquanto indivíduo responsável por um novo tipo de escrita, mas sua identidade passa por alguns deslocamentos discursivos significativos enquanto função-autor.

  11. L'autografia d'autore Cambiamenti nella realizzazione e nella concezione del libro dal XII secolo all'invenzione della stampa

    Directory of Open Access Journals (Sweden)

    Micol Long

    2012-06-01

    Full Text Available Si ritiene a volte che l'invenzione della stampa abbia innescato il cambiamento nel modo di concepire l'oggetto libro, segnando il passaggio dall'idea medievale a quella moderna. Occorre però tenere presente che esiste un'importante evoluzione interna al medioevo e che l'invenzione della stampa, per quanto fondamentale, è da inserire all'interno di questo processo più ampio, che a partire dal XII secolo circa trasforma l'uso e la funzione stessa della scrittura, rivoluziona il modo di leggere e di conseguenza il libro stesso, sia concettualmente sia come oggetto fisico. L'approccio scelto per questo studio mira a risalire alle radici culturali dei cambiamenti nelle pratiche del lavoro intellettuale e, viceversa, a indagare se e come tali cambiamenti abbiano potuto influenzare, attraverso le opere stesse, la cultura dell'epoca. Il fenomeno oggetto specifico dell'indagine è l'autografia letteraria d'autore che, eccezionale nell'alto medioevo, è testimoniata da una nuova e ininterrotta serie di casi a partire dall'XI-XII secolo, per poi diffondersi nei secoli successivi. Il panorama culturale della fine del medioevo appare dunque caratterizzato dalla tensione tra una ricorrente aspirazione all'individualizzazione del rapporto tra l'autore e il suo testo, che si realizzava in un modello di produzione libraria basato su uno stretto controllo dell'autore sul prodotto finale, dal punto di vista sia filologico-testuale sia grafico e materiale, e l'opposta tendenza all'allentamento del controllo dell'autore sulla propria opera, come naturale conseguenza di una sempre più vasta circolazione dei testi ma anche di una diversa concezione del ruolo autoriale. It is generally believed that the invention of printing triggered a cultural change, marking the passage between the medieval idea of the book and the modern one. It should be noted, though, that there was an important evolution through the Late Middle Ages, and that the printing revolution

  12. André-Louis Cholesky mathematician, topographer and army officer

    CERN Document Server

    Brezinski, Claude

    2014-01-01

    Outside the professional circles of topography and applied mathematics, the life and work of André-Louis Cholesky (1875–1918) are still relatively unknown to the scientific community. This new book appreciably widens the exposure of his remarkable personal achievements in topography and mathematics to a much larger international audience.   Cholesky is also interesting to historians because he is a perfect representative of the "scientists engineers" that, since the early 19th century, had issued from the French scientific high schools. Because they had received a high level of mathematical education, they were able to innovate in their practice of engineering. In the case of Cholesky, this resulted in original contributions in artillery, topography, numerical analysis and graphical calculation. In addition, the book places his education and works within the history of several European countries through the 17th to 19th centuries.   The book begins with Cholesky's biography, followed by his family’s hi...

  13. Pierre Darriulat is awarded the André Lagarrigue Prize

    CERN Multimedia

    2009-01-01

    Pierre Darriulat at the VATLY Laboratory in Hanoï. Former CERN Research Director, Pierre Darriulat, who is now Professor of Physics at VATLY in Hanoi (Vietnam), has won the 2008 André Lagarrigue Prize. This prize, instituted by the Linear Accelerator Laboratory (LAL) at Orsay under the aegis of the French Physical Society, is awarded to front-line researchers who have had responsibility for machine/detector construction and derived maximum scientific benefit from such projects, performed in a French laboratory or in close collaboration with French groups. Pierre Darriulat has received the award in recognition of his outstanding career at the CEA, at LBL (Berkeley) and at CERN from 1964 onwards. At CERN he managed the experiments at the Intersecting Storage Rings (ISR) before taking charge of the UA2 collaboration from 1980 to 1986, which participated in decisive discoveries at the ppbar collider. In particular, in 1982, the UA2 experiment began observing high trans...

  14. André Gide, Gide & Amrouche. Correspondance (1928-1950)

    OpenAIRE

    Amadessi, Veronica

    2016-01-01

    En 1928, le jeune Jean el-Mouhoub Amrouche captive l’attention d’André Gide dans une lettre qu’il lui adresse personnellement. À cette époque, la réputation de l’auteur de L’Immoraliste ne cesse de grandir, alors que l’expéditeur n’est qu’un «brillant» normalien inconnu au grand public. Il s’agit toutefois d’un jeune kabyle aux idées bien précises, qui exprime, dans cette première missive, sa volonté de se faire le porte-parole de l’identité kabyle tout en préservant son amour pour la France....

  15. Savisaar jäi alla Savisaarele / Andres Ammas

    Index Scriptorium Estoniae

    Ammas, Andres, 1962-2018

    2001-01-01

    Välissuhtlus on olnud Savisaare ja Keskerakonna Achilleuse kand algusest peale. Savisaar pidurdab Keskerakonna arengut. Autor: Isamaaliit. Ilmunud ka: Lääne Elu, 15. veebr. 2001, lk. 4; Hiiu Leht, 16. veebr. 2001, lk. 2; Vooremaa, 17. veebr. 2001, lk. 4; Nädaline, 17. veebr. 2001, lk. 2; Koit, 17. veebr. 2001, lk. 6; Võrumaa Teataja, 17. veebr. 2001, lk. 2; Järva Teataja, 20. veebr. 2001, lk. 2

  16. Correlation of the size of undescended testis with its location in various age groups

    Energy Technology Data Exchange (ETDEWEB)

    Taqvi, S R.H.; Akhtar, J; Batool, T; Farhat, M [National Inst. of child Health, Karachi (Pakistan). Dept. of Peadiatrics; Tabassum, R [National Inst. of Child Health, Karachi (Pakistan). Dept. of Radiology

    2006-09-15

    To assess the correlation of the size of undescended testis with its location in children of various age groups, per- operatively. Children presenting with undescended testis at surgical outpatient were recruited. Physical examination and relevant investigations (haemoglobin, ultrasound for location and size of testes) were performed. Patients were divided randomly into three age groups, group I (8 months - 2.5 years), group II (2.6 - 8 years), group III (8.1-13 years). At orchiopexy location and size of undescended testis were noted. Patients were further sub-divided into groups according to peroperative location of undescended testis, group A (intra-abdominal), group B (intra-canalicular), group C (distal to superficial inguinal ring - pubic). Where no testis was found, a separate group D was assigned. The size of undescended testis at different locations in various age groups was compared with reference to normal descended testicular size in the respective age group, for statistical significance. ANOVA test was used for intergroup comparison for the size of undescended testis and Student t- test was applied for comparison with reference to normal values of the size of testis. A total of 102 patients with undescended testis were included in the study. The total number of 107 testicular units were assessed. Group I had 28, group II, 41 and group III, 38 testes. There were 24 intra-abdominal, 68 intra-canalicular and 12 pubic in location. In 3 cases, no testis was found at exploration. We found no statistically significant difference amongst groups (p-value=0.090) between the size of the undescended testis at different peroperative locations. The size of undescended testis grew with the age as undescended testis of larger size were found in older age group as compared to younger age group. By applying Student t-test, we did not find statistically significant difference in relation to the size of undescended testis in various age groups in comparison to the

  17. Correlation of the size of undescended testis with its location in various age groups

    International Nuclear Information System (INIS)

    Taqvi, S.R.H.; Akhtar, J.; Batool, T.; Farhat, M.; Tabassum, R.

    2006-01-01

    To assess the correlation of the size of undescended testis with its location in children of various age groups, per- operatively. Children presenting with undescended testis at surgical outpatient were recruited. Physical examination and relevant investigations (haemoglobin, ultrasound for location and size of testes) were performed. Patients were divided randomly into three age groups, group I (8 months - 2.5 years), group II (2.6 - 8 years), group III (8.1-13 years). At orchiopexy location and size of undescended testis were noted. Patients were further sub-divided into groups according to peroperative location of undescended testis, group A (intra-abdominal), group B (intra-canalicular), group C (distal to superficial inguinal ring - pubic). Where no testis was found, a separate group D was assigned. The size of undescended testis at different locations in various age groups was compared with reference to normal descended testicular size in the respective age group, for statistical significance. ANOVA test was used for intergroup comparison for the size of undescended testis and Student t- test was applied for comparison with reference to normal values of the size of testis. A total of 102 patients with undescended testis were included in the study. The total number of 107 testicular units were assessed. Group I had 28, group II, 41 and group III, 38 testes. There were 24 intra-abdominal, 68 intra-canalicular and 12 pubic in location. In 3 cases, no testis was found at exploration. We found no statistically significant difference amongst groups (p-value=0.090) between the size of the undescended testis at different peroperative locations. The size of undescended testis grew with the age as undescended testis of larger size were found in older age group as compared to younger age group. By applying Student t-test, we did not find statistically significant difference in relation to the size of undescended testis in various age groups in comparison to the

  18. Väitlus tumma tekstiga : Hans Anton Schults ja Andres Saal / Katre Kikas

    Index Scriptorium Estoniae

    Kikas, Katre

    2006-01-01

    Artiklis käsitletakse H. A. Schults'i (1866-1905) 1903. a. Jakob Hurdale saadetud kirjutisi, kus ta polemiseerib oma kaasaegse Andres Saaliga arutledes "vanade eestlaste" moraali, rahvuse ja religiooni teemal

  19. Läänemere strateegia arvestab kodanike ettepanekutega / Jose Palma Andres ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Palma Andres, Jose

    2008-01-01

    Euroopa Komisjoni regionaalpoliitika peadirektoraadi direktor Jose Palma Andres vastab küsimustele, mis puudutavad avalikku debatti Läänemere strateegia üle ning Venemaa partnerlust Läänemere strateegias. Lisa: [Läänemere strateegia

  20. Tallinna idee / Andres Alver, Ott Alver, Marten Kaevats ; intervjueerinud Margit Mutso ; kommenteerinud Douglas Gordon

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2011-01-01

    17. veebruaril esitleti raamatut "Tallinna idee", mis on koostatud Eesti Kunstiakadeemia 4. kursuse arhitektuuritudengite kursuseprojektide põhjal. Tallinna teemal vestlevad tudengid Ott Alver ja Marten Kaevats ning nende juhendaja professor Andres Alver

  1. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva, 1980-

    2011-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  2. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva

    2006-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  3. Noblessneri Loomemaja = Noblessner Creative house / Rasmus Tamme, Jaanus Saarepera, Eero Jürgenson, Andres Jomp

    Index Scriptorium Estoniae

    2015-01-01

    Noblessneri Loomemaja Tallinnas Tööstuse 48/Peetri 11, valminud 2014. Arhitektid Rasmus Tamme, Jaanus Saarepera (ARS Projekt), sisearhitektid Eero Jürgenson, Andres Jomp (ARS Projekt). 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

  4. Giving Voice: Narrating silence, history and memory in André Brink ...

    African Journals Online (AJOL)

    Giving Voice: Narrating silence, history and memory in André Brink\\'s The Other Side of Silence and Before I Forget. ... Both narrators, though, draw attention to the problems associated with this reconstructive and potentially ... Article Metrics.

  5. André-Philip Lemke näitus Tallinnas / Mari Laaniste

    Index Scriptorium Estoniae

    Laaniste, Mari, 1977-

    1998-01-01

    Saksa kunstniku André-Philip Lemke (1970) näitus "Üks-üks armsa Jumala kasuks" 17. augustist Saksa Kultuuriinstituudis. Tööd on valgele paberile tavalise sinise pastapliiatsiga kirjutatud-joonistatud

  6. Korterelamu Tallinnas Weizenbergi 29 = Apartment Building in Tallinn, at 29 Weizenbergi Street / Andres Alver

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2001-01-01

    Puitvoodriga betoonist kastjas hoone. Projekteerija Alver Trummal Arhitektid. Arhitektid Andres Alver ja Tarmo Laht. Eriosad: Eesti Projekt. Projekt 1998, valmis 2000. 3 ill.: põhiplaan, välisvaade, Pille Lausmäe kujundatud korteri vaade

  7. Eestlane juhib Ukrainas EBRD investeeringuid / Andre Küüsvek ; interv. Henrik Ilves

    Index Scriptorium Estoniae

    Küüsvek, Andre

    2008-01-01

    Seni Euroopa Rekonstruktsiooni- ja Arengupanga (EBRD) Kasahstani osakonda juhtinud Andre Küüsvek valiti juhtima EBRD investeeringuid Ukrainas. Tänavu on plaanis investeerida Ukrainas 1,5 mld. dollarit

  8. Raio Piiroja : mängijatest ei suudetud maksimumi pigistada / Andres Kalvik

    Index Scriptorium Estoniae

    Kalvik, Andres, 1982-

    2007-01-01

    Vt. ka Postimees : na russkom jazõke 19. nov., lk. 13. Eesti koondis võlgneb EM-valikturniiri viimase kohtumise 2:0 Andorra üle suuresti Andres Operile. Kommenteerib Andorra koondise peatreener David Rodrigo

  9. Haapsalu Gümnaasiumi võimla = Haapsalu Gymnasium Gym / Andres Alver

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2001-01-01

    Projekteerija: Alver Trummal Arhitektid OÜ. Arhitektid Andres Alver, Sven Koppel, Tarmo Laht, Ulla Mets. Projekt 1998-1999, hoone valmis 2001. 11 ill.: asendi- ja korruse plaan, pikilõige, välis- ja sisevaated

  10. Proceedings of the 3. Summer School Jorge Andre Swieca in Nuclear Physics

    International Nuclear Information System (INIS)

    Lima, C.L.; Nemes, M.C.; Wolynec, E.

    1987-01-01

    This book contents the lectures and seminars presented during the Jorge Andre Swieca III Summer School-Nuclear Physics 1987 which happened in February 1987 in Itaipava - Rio de Janeiro - Brazil. (A.C.A.S.) [pt

  11. MASSIVE QUANTITIES OF PELAGIC Sargassum ON THE SHORES OF SAN ANDRES ISLAND, SOUTHWESTERN CARIBBEAN

    Directory of Open Access Journals (Sweden)

    Brigitte GAVIO

    2015-01-01

    Cantidades masivas de Sargassum pelágicos en las costas de San Andrés Isla, Caribe suroccidental Se reporta la llegada de una biomasa inusual de Sargassum flotante, compuesta por las especies S. fluitans y S. natans, a la costa nororiental de la isla de San Andrés. La época y el tamaño del evento nunca habían sido reportados anteriormente para la isla.

  12. Sex Cord-Gonadal Stromal Tumor of the Rete Testis

    Directory of Open Access Journals (Sweden)

    Kamran P. Sajadi

    2009-01-01

    Full Text Available A 34-year-old tetraplegic patient with suppurative epididymitis was found on follow-up examination and ultrasonography to have a testicular mass. The radical orchiectomy specimen contained an undifferentiated spindled sex cord-stromal tumor arising in the rete testis. Testicular sex cord-stromal tumors are far less common than germ cell neoplasms and are usually benign. The close relationship between sex cords and ductules of the rete testis during development provides the opportunity for these uncommon tumors to arise anatomically within the rete tesis. This undifferentiated sex cord-stromal tumor, occurring in a previously unreported location, is an example of an unusual lesion mimicking an intratesticular malignant neoplasm.

  13. Alterations in the developing testis transcriptome following embryonic vinclozolin exposure.

    Science.gov (United States)

    Clement, Tracy M; Savenkova, Marina I; Settles, Matthew; Anway, Matthew D; Skinner, Michael K

    2010-11-01

    The current study investigates the direct effects of in utero vinclozolin exposure on the developing F1 generation rat testis transcriptome. Previous studies have demonstrated that exposure to vinclozolin during embryonic gonadal sex determination induces epigenetic modifications of the germ line and transgenerational adult onset disease states. Microarray analyses were performed to compare control and vinclozolin treated testis transcriptomes at embryonic days 13, 14 and 16. A total of 576 differentially expressed genes were identified and the major cellular functions and pathways associated with these altered transcripts were examined. The sets of regulated genes at the different development periods were found to be transiently altered and distinct. Categorization by major known functions of altered genes was performed. Specific cellular process and pathway analyses suggest the involvement of Wnt and calcium signaling, vascular development and epigenetic mechanisms as potential mediators of the direct F1 generation actions of vinclozolin. Copyright © 2010 Elsevier Inc. All rights reserved.

  14. Apuntes para el concepto de autor en los poemarios de Borges

    Directory of Open Access Journals (Sweden)

    Christophe Larrue

    2006-07-01

    Full Text Available La imagen del poeta (como función literaria o como figura autobiográfíca que proporcionan directamente los textos y paratexto (aquél en contacto inmediato con el texto -prólogos, epílogos, y otro más distante -autobiografía, entrevistas es varia. Si los rasgos autobiográficos destilados apuntan todos a crear un personaje esencialmente dedicado a la literatura, el concepto de autor tal como lo expresan los textos es contradictorio : mientras unos niegan su existencia (se le substituye un anó...

  15. Exclusive nuclear location of estrogen receptors in Squalus testis.

    Science.gov (United States)

    Callard, G V; Mak, P

    1985-01-01

    An estrogen (E)-binding molecule having both occupied and unoccupied sites is restricted to nuclear subfractions in the testis of the spiny dogfish (Squalus acanthias). We investigated the hypothesis that a species characterized by high body-fluid osmolarity (1010 mosM) has an estrogen receptor (ER) that binds to chromatin with high affinity and consequently resists redistribution during tissue processing. Although the steroid binding and sedimentation properties of the Squalus nuclear ER conformed to those of classical ER, its elution maximum from DNA-cellulose was unusually high (0.55 M NaCl). A tendency to adhere tightly to cell nuclei was reflected in the high salt concentration (0.43 M KCl) required to extract 50% of the receptors from the nuclear compartment during homogenization and in the stability of the nuclear ER population in the presence of high concentrations of a nonionic solute (urea) or increased buffer volume. Mixing and redistribution experiments showed that nuclear ER could be quantitatively and qualitatively measured in cytosolic extracts, ruling out the possibility that soluble receptors were being masked. Although Squalus oviduct ER was similar to that of testis, ER in the testis and liver of a related elasmobranch (Potamotrygon) that maintains osmotic equilibrium at 300 mosM more closely resembled mammalian ER in its elution maximum from DNA-cellulose (0.22 M NaCl) and cytosolic/nuclear ratios in low-salt buffers. We conclude that Squalus testis has a single ER pool located exclusively in the nuclear compartment. These observations support a revised concept of steroid action and further indicate that the chromatin affinity of the hormone-ER complex is an important factor in determining subfractional distribution during tissue processing. PMID:3856265

  16. Impact of electronic-cigarette refill liquid on rat testis.

    Science.gov (United States)

    El Golli, N; Rahali, D; Jrad-Lamine, A; Dallagi, Y; Jallouli, M; Bdiri, Y; Ba, N; Lebret, M; Rosa, J P; El May, M; El Fazaa, S

    2016-07-01

    Electronic cigarettes (e-cigarettes) are becoming the fashionable alternative to decrease tobacco smoking, although their impact on health has not been fully assessed yet. The present study was designed to compare the impact of e-cigarette refill liquid (e-liquid) without nicotine to e-liquid with nicotine on rat testis. For this purpose, e-liquid with nicotine and e-liquid without nicotine (0.5 mg/kg of body weight) were administered to adult male Wistar rats via the intraperitoneally route during four weeks. Results showed that e-liquid with or without nicotine leads to diminished sperm density and viability, such as a decrease in testicular lactate dehydrogenase activity and testosterone level. Furthermore, quantitative real-time polymerase chain reaction (qRT-PCR) analysis identified a reduction in cytochrome P450 side-chain cleavage (P450 scc) and 17 beta-hydroxysteroid dehydrogenase (17βHSD) mRNA level, two key enzymes of steroidogenesis. Following e-liquid exposure, histopathological examination showed alterations in testis tissue marked by germ cells desquamation, disorganization of the tubular contents of testis and cell deposits in seminiferous tubules. Finally, analysis of oxidative stress status pointed an outbreak of antioxidant enzyme activities such as superoxide dismutase, catalase and gluthatione-S-transferase, as well as an important increase in sulfhydril group content. Taken together, these results indicate that e-liquid per se induces toxicity in Wistar rat testis, similar to e-liquid with nicotine, by disrupting oxidative balance and steroidogenesis.

  17. Alkohol, andre rusmidler og vold i epidemiologisk perspektiv

    Directory of Open Access Journals (Sweden)

    Kai Pernanen

    2009-10-01

    Full Text Available  SAMMENDRAGDen medisinske interessen for vold og voldsskader har økt kraftig i løpet av de siste to tiårene. Det epidemiologiskeperspektivet på vold har blitt forsterket og et mer etiologisk og preventivt syn på volden er mere merkbarinnenfor sosialmedisinsk forskning. Alkoholen er en etiologisk faktor som har vist seg å være forbundet med voldi de aller fleste samfunn. I denne artikkelen beskrives de viktigste epidemiologiske metodene og funnene i studietav alkoholens sammenheng med vold. Denne sammenhengen har vist seg ikke å være direkte, men er avhengig aven rekke andre faktorer, og noen forskjellige typer av kausal avhengighet beskrives i artikkelen. Den epidemiologiskeforskningen om andre rusmidlers sammenheng med vold er betydelig mindre omfattende enn den er foralkohol. Det er også åpenbart at andre rusmidler ikke er like sterkt sammenknyttet med vold som alkoholen.Pernanen K. Alcohol, other drugs, and violence in an epidemiological perspective.Nor J Epidemiol ENGLISH SUMMARYThe public health approach to violence has become increasingly accepted during the last couple of decades. Thishas led to more epidemiological research into violence, and a stronger medical interest in the etiology and preventionof violence. However, epidemiological research on the prevalence of violence in different societies is stillmainly criminological in nature, being based on information about violence that has come to the attention of thepolice or processed in the courts. The study of the relationship between alcohol use and violent behaviour is alsopredominantly based on police and court materials, although an increasing number of emergency room andhospitalization studies have examined the role of alcohol in injuries caused by violence.There are two basic methodological approaches in the study of the relationship between alcohol use andviolence. The alcohol-involvement studies estimate the extent to which drinking by the offender or the victim

  18. Arquitectura moderna: autores y producción en Mendoza - Argentina (1930-1970

    Directory of Open Access Journals (Sweden)

    Cecilia Raffa

    2013-06-01

    Full Text Available Este trabajo propone trazar un panorama general del desarrollo de la Arquitectura Moderna en Mendoza entre 1930 y 1970, a través de los autores y obras más significativos. La producción arquitectónica lograda en el período, en el presente de valor patrimonial, no cuenta con acciones gubernamentales ni legislación de protección. Esto se debe a dos razones concurrentes: La primera, desde el imaginario social el recorte temporal de lo patrimonial finaliza con la arquitectura de los años ’20 del siglo pasado. La segunda razón, la estética y la vigencia funcional de estas obras impiden poner la distancia crítica que requiere toda mirada histórica, aún más desde lo cultural. Vamos a revisar algunos autores a partir de sus trayectorias y su producción arquitectónica, con el objetivo de descubrir las singularidades de la producción local, haciendo aportes para la valoración de estos bienes y por ende para su patrimonialización.

  19. A NOVA NARRATIVA ITALIANA UM AUTOR, UM SÍMBOLO: PIER VITTORIO TONDELLI

    Directory of Open Access Journals (Sweden)

    Lucia Sgobaro Zanette

    2016-01-01

    Full Text Available Na literatura italiana dos anos oitenta, uma série de autores produziram textos classificados pela crítica de a nova narrativa italiana. Pier Vittorio Tondelli, que escreveu romances, contos, crônicas, textos críticos e peças de teatro durante toda a década, tornou-se - com as suas temáticas inerentes a uma realidade pós-moderna e, principalmente, ligadas a certas experiências da juventude do final dos anos setenta até o começo dos anos noventa - um autor-ícone desse período. Com a sua maneira de viver como homem em movimento, seu agudo senso de observa- ção, sua escritura, seu estilo, seu ritmo e seu forte sentire, ele se revelou um símbolo dessa nova geração de escritores, que promoveram uma importante renovação da literatura italiana, libertando-a dos impasses que a condicionavam: a dificuldade de leitura da narrativa neovanguardista e experimental, a falta de espessura da literatura de consumo e a obviedade da literatura realista, que, todavia, os novos escritores valorizavam bastante. Palavras-chave: literatura italiana, anos oitenta, renovação.

  20. Análisis económico del derecho de autor

    Directory of Open Access Journals (Sweden)

    Ana María Pérez

    2011-11-01

    Full Text Available La evolución de las tecnologías de la información y de la comunicación ha puesto de manifiesto la necesidad de crear un marco legislativo supranacional capaz de reglamentar eficazmente la protección del derecho de autor en el entorno digital y asegurar su comercialización en el ámbito mundial mediante el otorgamiento de licencias multiterritoriales y multirrepertorio. El otorgamiento de estas licencias sería posible mediante la creación de una taquilla única fundada en la gestión colectiva. El presente artículo aborda de manera comparativa los dos tipos de gestión de derechos de autor: la individual y la colectiva, en aras de evaluar las ventajas y desventajas económicas de cada uno de ellos. El análisis jurídico-económico de la naturaleza económica de la gestión de derechos, de sus costos, de los riesgos jurídicos que de ella se derivan y del control del ejercicio de la gestión por las sociedades de gestión colectiva permitirá tanto al titular de derechos como al usuario (consumidor determinar a cuál de los dos sistemas de gestión de derechos acogerse.

  1. Radiation dose and biological effects to mouse testis from sodium 32P-phosphate

    International Nuclear Information System (INIS)

    Mian, T.A.; Glenn, H.J.; Haynie, T.P.; Meistrich, M.L.

    1982-01-01

    Radiation dose to mouse testis was estimated to be about 1.65 rad per μCi of intravenously injected 32 P. This high dose to the organ was due to the incorporation of this isotope into the macromolecules of the testis. Up to 30% of the total testis activity was in DNA molecules. Biologic effects on mouse testis from 32 P were determined by testis weight loss and the decrease in the number of sperm heads in the testis. Number of sperm heads reached a minimum of 1.3% of control 36 days after injection of 3.5 μCi/g body weight of 32 P. Significant decreases in sperm head counts were observed after as little as 0.2 μCi/g body weight of 32 P. (author)

  2. Screening for Y microdeletions in men with testicular cancer and undescended testis

    DEFF Research Database (Denmark)

    Bor, Pinar; Hindkjaer, Johnny; Kølvraa, Steen

    2006-01-01

    PURPOSE: To investigate a possible association between testicular cancer or undescended testis and Y microdeletions. METHODS: It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were...... cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively. CONCLUSIONS: Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological...... cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis....

  3. Andres Puustusmaa - mees nagu jalgratas ehk Seitseteist kevadist hetke enne Moskva rongi väljumist / Andres Puustusmaa ; interv. Margus Mikomägi

    Index Scriptorium Estoniae

    Puustusmaa, Andres

    2008-01-01

    Venemaal tegutseva Eestist pärit režissööri Andres Puustusmaa mängufilm "18-14" esilinastub 10. jaanuaril Eestis. Lisaks tõlge filmi tutvustavast tekstist (www.1814.ru) : "Tsarskoje Selo Kõrilõikaja ja lütseumi kasvandikud". Artikkel rubriigis "Teatriküljed 1/25"

  4. Effects of a simulated microgravity model on cell structure and function in rat testis and epididymis

    Science.gov (United States)

    Hadley, Jill A.; Hall, Joseph C.; O'Brien, Ami; Ball, Richard

    1992-01-01

    The effect of simulated microgravity on the structure and function of the testis and epididymis cells was investigated in rats subjected to 7 days of tail suspension. Results of a histological examination revealed presence of disorganized seminiferous tubules and accumulation of large multinucleated cells and spermatids in the lumen of the epididymis. In addition, decreases in the content of testis protein and in testosterone levels in the testis, the interstitial fluid, and the epididymis were observed.

  5. Afståelsesret og andre former for lejerskifte

    DEFF Research Database (Denmark)

    Faber, Louise

    Afståelsesret og andre former for lejerskifte indeholder en analyse af lejerens adgang til at overdrage sit lejemål til en ny lejer.  Bogen bygger på forfatterens ph.d. afhandling.  Bogen er opdelt i to dele, en almindelig del, og en speciel del. I bogens almindelige del undersøges spørgsmålet, om...... lejerens ret til lejerskifte, når der ikke er taget stilling i lejeaftalen. Her fastlægges baggrundsretten med udgangspunkt i de obligationsretlige grundsætninger. I denne kontekst beskrives fremlejeretten, lejerens nærtståendes forsættelses- eller overtagelsesret ved lejrens død, skilsmisse m.v., og...... tillige retstillingen når lejeaftalen er indgået med flere lejere, et I/S, et ApS eller et A/S.  I bogens specielle del undersøges lejerens ret til at afstå eller genindtræde lejeforholdet, når lejerens har afståelsesret og genindtrædelsesret ifølge af lejeaftalen. Denne undersøgelse berører udlejerens...

  6. Arturo Andrés Roig, lector de Spinoza Arturo Andrés Roig, Spinoza Reader

    Directory of Open Access Journals (Sweden)

    Gerardo Oviedo

    2010-06-01

    Full Text Available La categoría spinoziana de conatus ocupa un puesto central en la arquitectónica discursiva de la filosofía práctica de Arturo Andrés Roig. Se trata de un fundamento previo del saber práctico-moral que oficia de figura explicativa originaria, pues el conatus concierne a una dimensión primaria de los entes. Su status teórico no se reduce por tanto a reconocer un aspecto antropológico entre otros, sino que adquiere un carácter vertebrador en el conjunto de las estrategias de fundamentación de la idea de "moral emergente" propuesta por nuestro filósofo. Nosotros estimamos que la condición ontológica del conatus es una instancia determinante de los planteos éticos y políticos de Arturo Roig. Dicha inflexión spinozista tan patente, sin embargo, no es tenida suficientemente en cuenta en algunas lecturas especializadas de la Argentina. En consecuencia, nos proponemos en primer término destacar la función constructiva que ese momento spinoziano posee en el pensamiento del maestro mendocino, ciñéndonos a un tratamiento de los textos en donde esa fuerza conceptual se torna más visible, sin excluir por cierto otros tratamientos concomitantes. Ello nos permitirá, en un segundo nivel más historiográfico de análisis, revalorar la recepción de Spinoza en los escritos de Arturo Roig.The Spinoza conatus category occupies a central place in the architectural discourse of practical philosophy of Arturo Andres Roig. This is a preliminary basis of practical knowledge and moral figure that offers originating explanation, as the conatus concerns a primary dimension of entities. Its theoretical status is not reduced only to recognizing anthropological aspect among others, but acquires a backbone in the set of strategies to substantiate the idea of "emerging moral" given by our philosopher. We believe that the ontological status is an instance of conatus determinant of ethical and political layout of Arturo Roig. Spinoza said turning so clearly

  7. Effect of laminaria japonica polysaccharides (LJP) on radiation damage of testis tissue in male rats

    International Nuclear Information System (INIS)

    Ren Shicheng; Luo Qiong; Yang Mingliang; Yang Jiajuan; Yan Jun; Li Zhuoneng; Wang Lihong; Cui Xiaoyan

    2007-01-01

    Objective: To observe the effect of laminaria japonica polysaccharides (LJP) on local radiation damage of testis tissue in male rats. Methods: The Wistar rats were randomly divided into 4 groups: the normal group, the model group, positive control group and LJP treatment group (50 mg·kg -1 ·d -1 ). LJP was applied to the treatment group for 10 d before local irradiation with γ-ray (6.0 Gy). The morphological change of the testis, organ index of testis and epididymides, sperm count, motility rate, superoxide dismutase (SOD) activity and malonic aldehyde (MDA) contents were measured. Results: LJP could make the damaged testis recover to near normal, elevate the organ index of testis and epididymides, promote the sperm count and motility rate, increase the activity of SOD and decrease the contents of MDA in testis tissue. Conclusions: LJP could inhibit testis tissue damage induced by local radiation, hence enhance the significant radioprotective effect to testis tissue. LJP has the conspicuous protective effect on radiation damage of testis tissue. (authors)

  8. Spazi d’autore. Riscrittura e passaggi di testo ne La strada di Levi

    Directory of Open Access Journals (Sweden)

    Matteo Martelli

    2016-07-01

    Full Text Available L’articolo propone un percorso d’analisi sulle strategie di riscrittura e di ripresa di alcuni testi di Primo Levi nel film documentario La strada di Levi e nell’opera parallela La prova. Focalizzandosi sul secondo romanzo di Levi, La tregua, questi lavori evadono dalle consuete pratiche di adattamento, sviluppando forme di riscrittura nelle quali la manipolazione critica delle testualità pregresse è posta in tensione con nuovi testi messi in scena, immagini, video, riorientando la percezione dell’ipotesto entro ulteriori linguaggi. È attraverso tale spazio di circolazione di linguaggi artistici e di pratiche intermediali, che gli autori Davide Ferrario e Marco Belpoliti sembrano poter condurre una riflessione sulle forme culturali dello sguardo e delle odierne pratiche di lettura della realtà (nella sua temporalità e memoria come nella sua spazialità e della sua traduzione attraverso codici semiotici molteplici. In tale spostamento costante del proprio oggetto di riscrittura, La strada di Levi e La prova si mostrano così quali nodi o reti di un processo di lettura dialettico del presente e del passato, in un tentativo di tracciare alcune mappe del mondo contemporaneo.   The essay suggests an analysis of the documentary film La strada di Levi and the correlated work La prova. Focusing on Primo Levi’s book La tregua, these works show a different attitude about adaptation through a constant reorientation of the source text and its juxtaposition with new texts and images, and through a projection of these elements within additional languages. In this way, the authors, Davide Ferrario and Marco Belpoliti, offer an experience of an intermedial artistic practice that involves a reflection on the cultural forms through which the texts interpret the reality (and its temporality or memory and its translation through multiple semiotic codes. The effect of this kind of work is the perception of the documentary film as a network that

  9. CERN celebrates André Martin’s 80th birthday

    CERN Multimedia

    2009-01-01

    André Martin, pictured at the ceremony held in honour of his 80th birthday. On 27 August 2009 CERN’s Main Auditorium was the venue for a celebration in honour of André Martin’s 80th birthday. Regarded as one of the most important theoretical physicists of his generation, André Martin is one of CERN’s most distinguished figures. The celebration began with a conference, followed by a concert and a reception. After the conference, André Martin made an emotional speech looking back over his fifty-year career and paying tribute to all those who had made important contributions during his time at CERN. "I was extremely happy, and I am very touched by this marvellous celebration you have organised for me. It was a wonderful idea, and I very much enjoyed the concert of Blandine Eynaud and John Devore. My wife, Schu, and I love the music of Gabriel Fauré", he said at the end. André Martin j...

  10. Francisco de Valderrama, verdadero autor de las mazas del Ayuntamiento de Sevilla

    Directory of Open Access Journals (Sweden)

    Santos Márquez, Antonio Joaquín

    2009-06-01

    Full Text Available In this article the author reveals the true creator of the maces of Seville Town Hall, Francisco de Valderrama, a rediscovered silversmith about whom new biographical data is offered. Also included is a detailed study of these civic maces (traditionally attributed erroneously to Francisco de Alfaro, key works of Sevillian Mannerism.

    En este artículo se da a conocer el verdadero autor de las mazas del ayuntamiento de Sevilla, Francisco de Valderrama, orfebre redescubierto del que además aportamos nuevos datos biográficos. Asimismo, hacemos un estudio pormenorizado de estas mazas capitulares, obra clave de la plástica manierista sevillana y que tradicionalmente había sido atribuida erróneamente a Francisco de Alfaro.

  11. Los primeros testimonios sobre Martin Seidel, autor de Origo et fundamenta religionis christianae

    Directory of Open Access Journals (Sweden)

    Pablo Toribio Pérez

    2016-06-01

    Full Text Available El tratado clandestino Origo et fundamenta religionis christianae ataca los fundamentos del cristianismo y propone una religión natural. Pese a que todas las copias manuscritas que lo conservan datan del siglo xVIII, se encuentran suficientes indicios que señalan al silesio Martin Seidel como su autor y documentan la existencia del texto a finales del siglo xVI o principios del xVII. Las primeras fuentes sobre Seidel lo vinculan con los antitrinitarios de Heidelberg (1570, los unitarios polacos (1580 y los “cripto-socinianos” de Altdorf (1610. En este artículo valoro dichas fuentes y corrijo a la luz de las mismas algunas afirmaciones de la crítica reciente sobre Seidel y su Origo.

  12. A Literatura e a Diluição do Autor

    Directory of Open Access Journals (Sweden)

    Daniel Marcolino Claudino Sousa

    2010-04-01

    Full Text Available

    Com Dom Quixote, segundo Adorno, tem-se a inauguração do Romance moderno e, por conseqüência, a constituição do autor moderno, um autor não absoluto, desinformado do destino de seus personagens, uma vez que agora o relato romanesco ‘precisa’ de recursos (por vezes, metalingüísticos que passem a evidenciar aspectos de verossimilhança (realismo para se fazer crível ao leitor. E ele o faz, gerando a idéia de níveis de realidade. Procedendo assim, Miguel de Cervantes gera um autor desprovido da autoridade (divina, que era própria dos tempos dos Rapsodos gregos. Busca-se nesse trabalho visualizar, pois a região em que se dá a morte ou a diluição do autor na literatura, este não propriamente gerado pela Metafísica, mas certamente, alimentado por ela, e que é tema de Derrida a Borges. Quando em A escrita de Deus Borges lança mão da idéia de uma alucinada linguagem em que a

  13. Autoría y dominio del hecho en los delitos económicos

    Directory of Open Access Journals (Sweden)

    Diego Mauricio Montoya Vacadíez

    2013-12-01

    Full Text Available La criminalidad de empresa es uno de los escenarios que más desafíos plantea en el mundo del Derecho penal contemporáneo. ¿Cómo imputaremos responsabilidad penal a cada uno de los individuos, del engranaje empresarial, que está presente en un delito económico? ¿Solo debe responder el ejecutor material? ¿Deben responder los superiores jerárquicos? ¿Deben responder a título de autores? ¿Deben responder a título de partícipes? ¿Qué conceptos dogmático-penales deben emplearse para atribuir responsabilidad penal en el entorno económico-empresarial? ¿Qué conceptos deben replantearse? ¿De qué conceptos debe prescindirse?

  14. Abordagem sociocultural: algumas vertentes e autores Sociocultural approach: some perspectives and authors

    Directory of Open Access Journals (Sweden)

    Adriana Ferreira Paes Ribas

    2006-04-01

    Full Text Available A necessidade de enfocar aspectos socioculturais nas investigações em psicologia tem sido destacada por diferentes autores, em diferentes épocas, e a abordagem sociocultural representa uma fonte conceitual proveitosa neste sentido. Este artigo tem como objetivo apresentar e discutir algumas idéias centrais da abordagem sociocultural, mudanças pelas quais esta abordagem passou nas últimas décadas, algumas de suas vertentes e autores. Os conceitos aqui discutidos não esgotam o tema, mas podem ser úteis para tentativas de articular investigações de diferentes temas em psicologia à abordagem sociocultural. As considerações finais apontam no sentido da necessidade de incluir as investigações em psicologia em um cenário conceitual que considere a cultura e o contexto social como elementos centrais, articulando as contribuições da psicologia transcultural e da cultura.The need to approach sociocultural aspects in psychological investigations has been emphasized by different authors in different times, and the sociocultural approach represents a profitable conceptual source in this sense. The purpose of this article was to discuss some concepts of the sociocultural approach, changes by which this approach went through last decades, some of their perspectives and authors. The concepts here discussed can be useful in the attempts to articulate psychological investigations in a sociocultural approach. The conclusions point to the need of including the investigations in psychology into a conceptual approach that considers the culture and the social context as central elements, articulating the contributions of the cross-cultural psychology, and of the culture.

  15. Response of the testis to a combined irradiation

    International Nuclear Information System (INIS)

    Kondratenko, V.G.; Ganzenko, L.F.

    1976-01-01

    Testes of dogs have been studied after a combined γ-irradiation (a continuous irradiation with a dose 0,2 rad/day in the course of one year, and acute exposures to doses of 8 and 42 rads thrice a year). As the time of the exposure and the radiation dose increase, the number of active tubules decreases and that of the desolate, increases. A specifity in the testis response to the combined irradiation, in contrast to merely continuous and fractionated exposures, has been detected

  16. Testicular sparing surgery in small testis masses: A multinstitutional experience

    Directory of Open Access Journals (Sweden)

    Andrea B. Galosi

    2016-12-01

    Full Text Available Introduction: The incidence of benign testicular tumors is increasing in particular in small lesion incidentally found at scrotal ultrasonography. Primary aim of this study was to perform radical surgery in malignant tumor. Secondary aim was to verify the efficacy of the diagnostic-therapeutic pathway recently adopted in management of small masses with testis sparing surgery in benign lesions. Materials and methods: In this multicenter study, we reviewed all patients with single testis lesion less than 15 mm at ultrasound as main diameter. We applied the diagnostic-therapeutic pathway described by Sbrollini et al. (Arch Ital Urol Androl 2014; 86:397 which comprises: 1 testicular tumor markers, 2 repeated scrotal ultrasound at the tertiary center, 3 surgical exploration with inguinal approach, intraoperative ultrasound, and intraoperative pathological examination. Definitive histology was reviewed by a dedicated uro-pathologist. Results: Twenty-eight patients completed this clinical flowchart. The mean lesion size was 9.3 mm (range 2.5-15. Testicular tumor markers were normal except in a case. Intraoperative ultrasound was necessary in 8/28 cases. We treated 11/28 (39.3% with immediate radical orchiectomy and 17/28 (60.7% with testis-sparing surgery. Definitive pathological results were: malignant tumor in 6 cases (seminoma, benign tumor in 10 cases (5 Leydig tumors, 2 Sertoli tumors, 1 epidermoid cyst, 1 adenomatoid tumor, 1 angiofibroma, benign disease in 11 (8 inflammation with haemorragic infiltration, 2 tubular atrophy, 1 fibrosis, and normal parenchyma in 1 case. We observed a good concordance between frozen section examination and definitive histology. Any malignant tumor was treated conservatively. Any delayed orchiectomy was necessary based on definitive histology. Conclusions: The incidence of benign lesions in 60% of small testis lesions with normal tumor markers makes orchiectomy an overtreatment. Testicular sparing surgery of single

  17. Andrés Chiautla, Estado de México

    Directory of Open Access Journals (Sweden)

    J. Tiburcio-Rosales

    2007-01-01

    Full Text Available En el presente trabajo se realizó un Ordenamiento Ecológico Territorial del municipio de San Andrés Chiautla. La metodología empleada fue la propuesta por el INE-SEMARNAP, la cual emplea la variante de los sistemas complejos asociados a la metodología de SEDUE, utilizando las variantes del Levantamiento Fisiográfico realizado a través del SIG para la caracterización de los subsistemas natural y socioeconómico; así como la utilización de los términos de referencia para las transformaciones y permanencias del uso del suelo obtenidos del Programa Estatal de Ordenamiento Territorial elaborado por SEDESOL. Se generaron ocho productos como resultado de la etapa de caracterización del subsistema natural y socioeconómico los cuales son: la calidad ecológica de los recursos naturales, la fragilidad natural, los cambios del uso del suelo y vegetación, la presión de la población sobre su entorno natural, la distribución de la población, los niveles de bienestar de la población, la dinámica espacial y temporal de la población y los aspectos socioeconómicos. Después de la etapa de caracterización se llevó a cabo la integración del subsistema natural para obtener la estabilidad ambiental y las políticas ambientales. Como resultado final se obtuvieron las tablas de uso, políticas y criterios para normalizar la utilización del espacio territorial.

  18. Santo André: Integración de Programas para Promover la Inclusión Social

    OpenAIRE

    Rosana Denaldi

    2003-01-01

    En este trabajo trataremos del programa "Santo André Más Igual", desarrollado desde 1998 en la ciudad de Santo André ubicada en la Región del Gran ABC, en la Región Metropolitana de San Pablo (RMSP) Brasil.

  19. Energy Transition Initiative: Island Energy Snapshot - San Andres and Providencia (Fact Sheet); NREL(National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-03-01

    This profile provides a snapshot of the energy landscape of the Archipelago of San Andres, Providencia, and Santa Catalina (unpopulated), also known as San Andres and Providencia, which is equidistant between Costa Rica and Jamaica and 775 kilometers northwest of Colombia. The archipelago is part of Colombia, though Nicaragua has also laid claim to it.

  20. Vigencia de la filosofía de Kant en dos expresiones actuales de la inteligencia filosófica en América Latina: Arturo Andrés Roig y Franz J. Hinkelammert The Force of Kant's Philosophy in Two Present Expressions of the Philosophical Intelligence in Latin America: Arturo Andrés Roig y Franz J. Hinkelammert

    Directory of Open Access Journals (Sweden)

    Yamandú Acosta

    2006-12-01

    Full Text Available Al cumplirse doscientos años de la muerte de Immanuel Kant 2004, considerar la vigencia de su pensamiento filosófico, se constituyó en un imperativo categórico, para quienes nos inscribimos en la tradición de la filosofía occidental. En cumplimiento del mismo, el texto que se presenta se ocupa de la vigencia de la filosofía del filósofo de Königsberg a través de la consideración de dos expresiones de la inteligencia filosófica en América Latina: Arturo Andrés Roig (Mendoza, Argentina, 1922 y Franz J. Hinkelammert (Emsdetten, Alemania,1931. Los programas de investigación en curso de los dos autores elegidos, en el abordaje y desarrollo de distintos tópicos, proceden argumentativamente desde, contra y más allá de Kant, exhibiendo una singular vigencia de su filosofía al interior de los mismos. En el pensamiento de Arturo Andrés Roig, los tópicos de referencia que se consideran son: la normatividad del pensamiento filosófico, la filosofía de la historia, la fundamentación de una moral emergente y la fundamentación de una estética motivacional. De la producción teórica de Franz J. Hinkelammert, se presentan: la crítica a la razón utópica y el realismo político, la crítica trascendental de los marcos categoriales de los pensamientos sociales, la trascendentalidad del sujeto y el problema del universalismo ético en la tensión entre la ética de la responsabilidad y la ética de principios. Surge de la consideración de los asuntos enumerados, que en relación al universalismo abstracto de Kant, estos dos exponentes de la inteligencia filosófica en América Latina, convergen en la fundamentación de un universalismo concreto.Currency of Kant's philosophy in two recent expressions of the philosophical intelligence in Latin America: Arturo Andrés Roig and Franz J. Hinkelammert. When it is twohundred years of Immanuel Kant´s death (2004, to consider the currency of his philosophical thought means a categorial must

  1. Leiomyoma of Testis –Rare Benign Mimicker of Testicular Malignancy

    Directory of Open Access Journals (Sweden)

    Asif Baliyan

    2017-10-01

    Full Text Available Leiomyomas are benign tumours that originate from any organ containing smooth muscles. The testis is an extremely rare site. We report a case of testicular leiomyoma in a 50-year-old. Testis-associated leiomyomas are a benign and rare disease presenting as a painless, slowly-growing mass. Only histological examination with immunohistochemistry can validate the diagnosis.

  2. Efek ekstrak testis terhadap jumlah implantasi dan jumlah anak pada mencit (Mus musculus

    Directory of Open Access Journals (Sweden)

    Sri Puji Astuti Wahyuningsih

    2012-02-01

    Full Text Available Extract of testis contains the testis specific proteins. The testis proteins may raise immune responses. The immune responses arethe antibodies against testis specific anti-protein. The reaction between the antibodies and the sperms can inhibit fertilization. Thisprocess has contraception effects. This research used 24 female and 20 male mice strain Balb/c. The experiment used the completerandom design with 4 concentration treatments (0, 500, 1000, and 2000 μg extracts of testis and 3 replications. Mice were injected 3times with time interval 21 days. After 15 days from the rising of vaginal plug, 3 mice were dissected and counted the implantation. Theothers mice were waited until delivered of the children. The datas were analyzed by ANOVA and LSD (α = 5%. The results showed thatextract of testis did not influence the amount of implantation at the uterus endometrial, but it decreased the amount of children. Theeffective concentration of extract testis is 2000 μg. So, this study showed that the intraperitoneum injection of the extract of testis hadcontraception effects.

  3. Gene expression profiles in testis of pigs with extreme high and low levels of androstenone

    DEFF Research Database (Denmark)

    Moe, Maren; Meuwissen, Theo; Lien, Sigbjørn

    2007-01-01

    Boar taint is a major obstacle when using uncastrated male pigs for swine production. One of the main compounds causing this taint is androstenone, a pheromone produced in porcine testis. Here we use microarrays to study the expression of thousands of genes simultaneously in testis of high and low...

  4. Concentration of radiolabeled cholesterol in a feminizing adenoma of the testis

    International Nuclear Information System (INIS)

    Leonard, J.M.; Rudd, T.G.; Gurgess, E.C.; Monda, G.A.

    1979-01-01

    Quantitative tissue studies demonstrated increased 19-[ 131 I]-iodocholesterol concentration in a feminizing adenoma of the testis. The potential application of iodocholesterol and its isomers in the detection of steroid-secreting neoplasms of the testis and ovary is suggested

  5. The effect of microgravity on tissue structure and function of rat testis

    Directory of Open Access Journals (Sweden)

    Ye Ding

    2011-12-01

    Full Text Available To explore whether an environment of weightlessness will cause damage to the reproductive system of animals, we used the tail-suspension model to simulate microgravity, and investigated the effect of microgravity on the tissue structure and function of the testis in sexually mature male rats. Forty-eight male Wistar rats weighing 200-250 g were randomly assigned to three groups (N = 16 each: control, tail traction, and tail suspension. After the rats were suspended for 7 or 14 days, morphological changes of testis were evaluated by histological and electron microscopic methods. The expression of HSP70, bax/bcl-2 and AR (androgen receptor in testis was measured by immunohistochemistry. Obvious pathological lesions were present in the testis after the rats were suspended for 7 or 14 days. We detected overexpression of HSP70 and an increase of apoptotic cells, which may have contributed to the injury to the testis. The expression of AR, as an effector molecule in the testis, was significantly decreased in the suspended groups compared to control (P < 0.01. We also observed that, with a longer time of suspension, the aforementioned pathological damage became more serious and some pathological injury to the testis was irreversible. The results demonstrated that a short- or medium-term microgravity environment could lead to severe irreversible damage to the structure of rat testis.

  6. Shedding Light on the Sea: André Morel's Legacy to Optical Oceanography

    Science.gov (United States)

    Antoine, David; Babin, Marcel; Berthon, Jean-François; Bricaud, Annick; Gentili, Bernard; Loisel, Hubert; Maritorena, Stéphane; Stramski, Dariusz

    2014-01-01

    André Morel (1933-2012) was a prominent pioneer of modern optical oceanography, enabling significant advances in this field. Through his forward thinking and research over more than 40 years, he made key contributions that this field needed to grow and to reach its current status. This article first summarizes his career and then successively covers different aspects of optical oceanography where he made significant contributions, from fundamental work on optical properties of water and particles to global oceanographic applications using satellite ocean color observations. At the end, we share our views on André's legacy to our research field and scientific community.

  7. El patrimonio identitario de la comunidad de San Andrés

    Directory of Open Access Journals (Sweden)

    Carlos Córdova Martínez

    2006-01-01

    Full Text Available La identidad y el patrimonio son elementos recurrentes si se quiere defender la cultura frente a un mundo globalizado. Dicha labor debe realizarse de lo local a lo nacional y viceversa. El trabajo aborda el patrimonio de una pequeña comunidad holguinera, el Consejo Popular de San Andrés, cuyo centro es el poblado homónimo. Con un largo devenir histórico, que se remonta a fines del siglo XVI. San Andrés atesora un rico patrimonio, que puede incluirse fundamentalmente dentro de la cultura campesina.

  8. Pedagogic Juan Andrés Cué Bada's work (1935-1979

    Directory of Open Access Journals (Sweden)

    Janet Reinaldo-Delgado

    2017-06-01

    Full Text Available Juan Andrés Cué Bada was born on November 30, 1908 in the province of Las Tunas. He had an active political participation against Machado and Batista, while he dedicated himself to private education. After the triumph of the Cuban Revolution in 1959 he moved to Santiago de Cuba and in 1962 began his professorial course at the Universidad de Oriente until he died in 1979. Because of the lack of knowledge about his figure and his work as a teacher, this article Intends to explain the pedagogical work of Juan Andrés Cué Bada between the years 1935 and 1979.

  9. Medidas cautelares innominadas en la protección de los derechos de autor y conexos en Colombia

    Directory of Open Access Journals (Sweden)

    Nixon Jefrey Gil Aguirre

    2016-12-01

    Full Text Available Actualmente, el ejercicio de funciones jurisdiccionales atribuidas a las autoridades administrativas ha generado interpretaciones judiciales confusas, en la aplicación de medidas cautelares innominadas para la protección de derechos de autor y conexos en Colombia; así lo evidencia el análisis realizado a las medidas cautelares descritas en la Ley 1493 del año 2011, que otorgó competencias de inspección, vigilancia y control sobre las sociedades de gestión colectiva de derechos de autor y conexos; en este sentido se requiere describir las funciones jurisdiccionales de la Dirección Nacional de Derecho de Autor respecto a las medidas cautelares y su importancia en la protección de los derechos de autor y conexos, al igual que analizar las medidas cautelares innominadas desde su origen, las características y lo propuesto por la Corte Constitucional en materia de funciones jurisdiccionales de la Dirección Nacional de Derecho de Autor y respecto de la procedencia de las medidas cautelares innominadas como competencia de esta entidad. Se concluye que las medidas cautelares nominadas no son suficientes, y que se hace necesario acudir a las medidas cautelares innominadas, como herramienta jurídica del funcionario administrativo, sin que ello implique arbitrariedad y prejuzgamiento en el proceso.

  10. Effects of hyperthermia and radiation on mouse testis stem cells

    International Nuclear Information System (INIS)

    Reid, B.O.; Mason, K.A.; Withers, H.R.; West, J.

    1981-01-01

    The response of mouse testis stem cells to hyperthermia and combined hyperthermia-radiation treatments was assayed by spermatogenic colony regrowth, sperm head counts, testis weight loss, and fertility. With the use of spermatogenic colony assay, thermal enhancement ratios at an isosurvival level of 0.1 were 1.27 at 41 degrees, 1.80 at 42 degrees, and 3.97 at 43 degrees for testes exposed to heat for 30 min prior to irradiation. Sperm head counts were reduced by heat alone from a surviving fraction of 0.58 at 41 degrees to 0.003 at 42.5-43.5 degrees. Curves for sperm head survival measured 56 days after the testes had been heated for 30 min prior to irradiation were biphasic and showed a progressive downward displacement to lower survival with increasing temperature. The 41, 42, and 43 degrees curves were displaced downward by factors of 2, 58, and 175, respectively. The proportion of animals remaining sterile after 30 min of heat (41-43 degrees) and the median sterility period in days increased with increasing temperature. The minimum sperm count necessary to regain fertility was 13% of the normal mouse level

  11. Distribution of the DAZ gene transcripts in human testis.

    Directory of Open Access Journals (Sweden)

    J B Warchoł

    2004-07-01

    Full Text Available Involvement of variety of genes, especially located on Y chromosome, is critical for the regulation of spermatogenesis. In particular, fertility candidate genes such as deleted in azoospermia (DAZ are believed to have important function in sperm production, since DAZ is frequently deleted in azoospermic and severy oligozoospermic men. The role of the DAZ gene is supported by its exclusive expression in the testis and by its deletion in about 10% of azoospermic and severely oligozoospermic patients. The distribution of DAZ transcripts in seminiferous epithelium of human testis is reported in the present study. The use of Adobe Photoshop and Scion Image softwares allowed for semi-quantitative analysis of in situ RT-PCR (ISRT-PCR results. The intensity of ISRT-PCR product's fluorescence was different within individual seminiferous tubules. It was clearly shown by using the pseudocolour scale and transforming the intensity of the fluorescence into levels of greyscale images. The more intense fluorescence characterised single spermatogonia and those organized in small groups inside separate tubules. The most intense accumulation of DAZ mRNA was observed in spermatogonia.

  12. Utopías y nacionalismo cultural en América Latina. La interpretación de Andrés Sabella a la contribución de Mariátegui, Vallejo y Eguren Utopias and Cultural Nationalism in Latin America. Andres Sabella's Interpretation of Mariategui's, Vallejo's, and Eguren's Contributions

    Directory of Open Access Journals (Sweden)

    José Antonio González Pizarro

    2012-06-01

    Full Text Available Se hace una relectura de los autores peruanos José Carlos Mariátegui, César Vallejo y José María Eguren, desde la visión del poeta y ensayista chileno Andrés Sabella, poniendo el énfasis en la noción de utopía -como lo no lugar, lo imposible- no solamente en el ámbito político-económico sino desde la construcción de un ''mundo'' donde la imaginación, la ensoñación, pueda edificar en la niñez, una visión contra la fealdad, lo monocromático, estableciendo con fuertes imágenes líricas el ''mundo imposible'' de lo que se estimaba lo ''perdido'' en la infancia. La interpretación de Sabella -al igual que los textos de los autores peruanos- se sitúa en un contexto de la construcción de un nacionalismo cultural en el continente, como correlato de la búsqueda de una identidad latinoamericana expresiva de la diferencia con los Estados Unidos.A re-reading of Peruvian authors José Carlos Mariátegui, César Vallejo, and José María Eguren is made from the view of the Chilean poet and essay writer Andres Sabella, putting emphasis on the notion of utopia -as the non-place, the impossible- not only in the political and economical ambit, but from the construction of a ''world'' where imagination and dreaming may build, during childhood, a view against ugliness and monocromaticity, establishing the ''impossible world'' of what was estimated as ''lost'' during childhood with strong lyric images. Sabella's interpretation -like Peruvian author's texts- lies within the context of a cultural nationalism construction, as a correlation to the search of a Latin American identity expressing the differences with the USA.

  13. Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac

    Directory of Open Access Journals (Sweden)

    Kusuma Venkatesh

    2016-01-01

    Full Text Available Sertoli cell tumors (SCTs are rare tumors accounting for <1% of all testicular tumors. Here, we report a rare case of SCT in a 60-year-old man presenting as a painless swelling in the right groin since childhood. Clinically, he presented with right-sided inguinal hernia with absence of the right testis. He had normal left testis and had no gynecomastia or infertility. The specimen of hernial sac showed testis with a 1.6 cm × 1.5 cm nodular mass having gray tan-cut surface. Histopathologically, the testis showed atrophy and the nodular portion showed tumor cells arranged in tubular and microcystic pattern, with no solid pattern or necrosis. The diagnosis of SCT was confirmed with immunohistochemical staining for inhibin which showed fine granular cytoplasmic positivity. Cryptorchid testis having SCT and presenting as a content of inguinal hernia is a rare occurrence.

  14. Rare presentation of a testicular angiofibroma treated with testis sparing surgery.

    Science.gov (United States)

    Leone, Luca; Fulvi, Paola; Sbrollini, Giulia; Filosa, Alessandra; Caraceni, Enrico; Marronaro, Angelo; Galosi, Andrea B

    2016-12-30

    Testicular benign tumors are very rare (< 5%). Testicular Angiofibroma (AF) is one of those, however the gold standard of treatment and follow-up is still unclear. A 47 years-old man with only one functioning testis was referred to our clinic for a palpable right testicular mass and atrophic contralateral testis. Patient underwent testis-sparing surgery with inguinal approach and intraoperative frozen sections examination with diagnosis of AF. Final histology confirmed AF. Post-operative follow-up was uneventful. Clinical and ultrasonographic follow-up was negative after 8 months. We report a conservative surgery in a patient with AF of the solitary testis. AF is a benign para-testicular fibrous neoplasm that could be misinterpreted as malignant tumor and treated with orchiectomy. Testis-sparing surgery is recommended in this case with intraoperative pathological examination. The excision of the mass is enough but in front of a possible recurrence a long follow-up is advisable.

  15. La Cita como suspenso: el Autor-Dios y la Nada

    Directory of Open Access Journals (Sweden)

    Daniel Basilio

    2015-04-01

    Full Text Available [es] Las sociedades modernas están regidas por la idea de Autor, que no es otra cosa que el propio sujeto jurídico, abstracto y autosuficiente que se constituye como individuo canónico de la época. El Autor-Dios vuelve a las obras entes antropomórficos, organismos jerárquicamente delimitados que le pertenecen mediante su firma. Cada obra convive con el suspenso de sus signos muertos, que son resucitados por esos otros, aquellos que anidarán el nuevo porvenir. Este ensayo intenta rescatar el pensamiento de Leibniz y Tarde bajo la concepción de amistad política de Derrida: el origen plural del Ser como una Nada constitutiva que se expresa en el arte de citar. La amistad se erige como un compromiso que sobrevive a la muerte; mediante la escritura queremos dejar algo para los que vendrán; mediante la cita, trascendemos el umbral de la muerte para darle vida a los signos muertos, al legado de aquellos que nos precedieron. Convivimos con una ajenidad fundante. La cita es virus, infección: se interna en la carne para cambiar por completo nuestro sistema de pensamiento. La cita es también profanación: extraemos símbolos del orden de lo sagrado para volverlos al orden de lo real e imprimirles nuestro carácter singular. [en] Modern societies are governed by the idea of an Author, which is a variable of the legal, abstract and self-sufficient subject that is established as the canonic individual of the era. The God-Auhor turns the works in anthropomorphic entities, delimited organisms that belongs to him by his sign. Each work lives in suspense with its dead signs, which will be resurrected by those who will construct the future. This essay is about the thoughts of Leibniz and Tarde about the Derrida´s politics of friendship: the plural origin of Being as Nothingness that expresses the art of quoting. Friendship is a compromise that survives death; the writing lefts its words for those about to come; quoting transcend the threshold of death

  16. Misconduct by researchers and authors Malas prácticas de investigadores y autores

    Directory of Open Access Journals (Sweden)

    Harvey Marcovitch

    2007-12-01

    Full Text Available Most scientific research is conducted properly and reported honestly but a few authors invent or manipulate data to reach fraudulent conclusions. Other types of misconduct include deliberately providing incomplete or improperly processed data, failure to follow ethical procedures, failure to obtain informed consent, breach of patient confidentiality, improper award or denial of authorship, failure to declare competing interests, duplicate submission and plagiarism. Editors, peer reviewers and publishers may also act wrongly. Good practice guidelines are available from the International Committee of Medical Journal Editors (The Vancouver Group and the Council of Science Editors, amongst others. The Committee on Publication Ethics provides flowcharts to assist editors deal with authorial misconduct. Examples are provided of cases involving epidemiological or public health research, reported to COPE over the last 9 years. Suggestions are offered as to how misconduct might be handled in future.Aunque la mayor parte de la investigación científica se realiza y comunica de manera honesta, algunos pocos autores inventan o manipulan los datos para obtener conclusiones fraudulentas. Hay, además, otros tipos de malos comportamientos, como proporcionar deliberadamente información incompleta o mal procesada, vulnerar la confidencialidad de los pacientes, atribuir o denegar improcedentemente la autoría, no declarar algún conflicto de interés, publicar de forma duplicada y el plagio. Los editores y revisores externos también pueden actuar erradamente. El Comité Internacional de Directores de Revistas Médicas (el Grupo de Vancouver y el Consejo de Editores Científicos han elaborado guías de buena práctica. El Comité de Ética en Publicación proporciona diagramas para ayudar a los editores a afrontar los casos de mal comportamiento. En este trabajo se comentan algunos casos prácticos de mala práctica en investigación en epidemiología y salud p

  17. Effective Condition for Whole Testis Cryopreservation of Endangered Miho Spine Loach (Cobitis choii) Through the Optimization of Mud Loach (Misgurnus mizolepis) Whole Testis Cryopreservation Condition.

    Science.gov (United States)

    Kim, J J; Nam, Y K; Bang, I C; Gong, S P

      BACKGROUND: Miho spine loach (Cobitis choii) is an endangered Korean endemic fish. Whole testis cryopreservation is a good way for species preservation, but needs to the sacrifice of a large number of fish to optimize the freezing condition. Considering this limitation, a surrogate fish species was used for the protocol development. This study was to establish the effective condition for Miho spine loach whole testis cryopreservation by optimizing the conditions for whole testis cryopreservation in an allied species, mud loach (Misgurnus mizolepis). The condition for whole testis cryopreservation was optimized in mud loach first, and then the optimal condition was applied to Miho spine loach testes. The optimal condition for mud loach testis cryopreservation consists of the freezing medium containing 1.3 M dimethyl sulfoxide, 6% fetal bovine serum and 0.3 M trehalose, -1 C/min cooling rate and 26 degree C thawing temperature, which also permits effective cryopreservation of Miho spine loach testes. An effective cryopreservation condition for whole testis of the endangered Miho spine loach has been established by using mud loach as a surrogate fish.

  18. Dos «coplas del fuego» sefardíes en busca de autor

    Directory of Open Access Journals (Sweden)

    Romero, Elena

    2005-01-01

    Full Text Available The present article presents the edition and study of two anonymous Sephardic coplas, namely the so-called El incendio de Salónica de 1839, preserved in a manuscript from Belgrade (1861, and El incendio de Constantinopla de 1883, known from four oral versions. The author suggests the exact place and date of the fires, as well as the authorship of both compositions, namely Sa‘adi Halevi and Ya‘aqob Yonah, respectively. If the interpretation proves correct, these coplas would constitute the oldest extant compositions by the two famous Saloniki copleros.

    En el presente artículo se editan y estudian dos coplas sefardíes que nos han llegado anónimas: las denominadas El incendio de Salónica de 1839, procedente de un manuscrito de Belgrado (1861; y El incendio de Constantinopla de 1883, conservada en cuatro versiones orales. En el estudio la autora determina el lugar y fecha de los incendios, así como sus posibles autorías -Sa‘adí Haleví y Ya‘acob Yoná, respectivamente-; de estar en lo cierto, se trataría de las coplas más antiguas que hoy por hoy conocemos de esos dos famosos copleros salonicenses.

  19. EDUCAÇÃO ESCOLAR E MARGINALIZAÇÃO DE ADOLESCENTES AUTORES DE ATOS INFRACIONAIS

    Directory of Open Access Journals (Sweden)

    JULIO CESAR FRANCISCO

    Full Text Available O presente artigo tem por finalidade identificar a relação entre o processo de marginalização dos atendidos por medidas socioeducativas e a educação escolar e não escolar. A investigação trata de um problema que atinge parte de uma população empobrecida economicamente e marginalizada social e culturalmente: o envolvimento de um número cada vez maior de adolescentes com a prática de atos infracionais. Foram utilizadas, além da legislação em vigor, algumas referências teóricas: Silva (2003; Becker (1997, Zaluar (1994, Merton (1967, Goffmam (1981 e Veronese e Lima (2009, que contribuíram com a concepção que têm do problema da marginalidade, envolvendo crianças e adolescentes em conflito com a lei. Além desses,Saviani, em Escola e Democracia (1983, é tomado como um autor que mostra como a organização e o funcionamento da escola interferem nessa questão. Por último, apresento uma proposta educativa a ser desenvolvida nas medidas socioeducativas, em que é articulado à Pedagogia Histórico-Crítica de Saviani com a Pedagogia Libertadora de Paulo Freire, as quais sugerem um ato educativo que possibilite o desvelamento das condições opressoras para nelas atuar e transformar.

  20. Taboo Icons: The Bodily Photography of Andres Serrano

    Directory of Open Access Journals (Sweden)

    Tyler Shine

    2015-08-01

    Full Text Available   Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Verdana;} Andres Serrano’s photography is often dismissed as being shocking for the sake of being shocking. His infamous photograph Piss Christ (1987 is the oft-cited example at the center of the National Endowment for the Arts controversies during the Culture Wars of the 1980s and 1990s. I return to Piss Christ as a way to expand the interpretative scope of Serrano’s early photographs, which I call “taboo icons” because of their ambiguity and ability to crisscross symbolic boundaries in the unstable space between sacred and profane, thus making his images both powerful and potentially dangerous. Building upon previous scholarship that draws connections between modern and early modern aesthetic practices, I look to the material practices of Christianity in medieval Europe characterized by a sophisticated visual culture that mixed both the physical and the spiritual. The intensifying rejection and reverence of matter resulted in divergent responses, yet the contradictory nature of matter remained central to the ideological beliefs of Christianity where the doctrines of Creation, Incarnation, and Resurrection are at its core. Serrano’s visceral photographs are emphatically material and can productively be read vis-à-vis medieval visual culture. In doing so, this reading changes the narrow perception of Serrano’s early photographs and provides an alternative understanding of his artistic project that reinserts religion into contemporary American art discourse.

  1. Autores Clásicos en la biblioteca del ilustrado Antonio Ruiz De Padrón

    Directory of Open Access Journals (Sweden)

    Francisco Salas Salgado

    2014-12-01

    Full Text Available Se estudia en este artículo los libros de autores grecolatinos que poseía la amplia biblioteca del ilustrado canario Antonio Ruiz de Padrón (1757-1823, cuyo conocimiento debemos a los inventarios realizados en 1814 y 1823. Se comprueba de esta manera la vigencia de los autores clásicos propiciada con toda seguridad por enorme importancia que la corriente neoclásica tuvo en la época de la Ilustración.http://dx.doi.org/10.14195/2183-1718_66_20

  2. André François Boshoff (1945-2016)

    African Journals Online (AJOL)

    Campbell Murn

    National Herbarium in Pretoria and at Stellenbosch. In 1974 André was awarded a. BSc (honours) postgraduate degree in Wildlife Management at the. University of Pretoria (Eugène. Marais. Chair of. Wildlife. Management). It was during this period that he developed a greater interest in birds, especially in their conservation ...

  3. Tõnu Anton kahtlustab linnaisasid omakasu jahtimises / Tõnu Anton, Andres Kõiv, Ando Hagel ; interv. Ulis Guth

    Index Scriptorium Estoniae

    Anton, Tõnu, 1942-

    2004-01-01

    Võru linnavolikogu opositsiooni kuuluv keskerakondlane Tõnu Anton kritiseerib sotsiaalabitalituse ruumide remondirahade kasutamist ja kahtlustab linnavalitsust riigihangete käigus raha kõrvaldamises. Linnapea Ando Hagel ja abilinnapea Andres Kõiv lükkavad süüdistused tagasi

  4. San Andrés: Cotidianidad turística vs. idealismo desarrollista

    Directory of Open Access Journals (Sweden)

    José Ernesto Ramírez

    1988-01-01

    Full Text Available Pragmatic adaptation and idealistic intervention: An analytical description of development agencies within a context of political clientelism in San Andrés Island Colombia. (Tesis de doctorado en desarrollo. University Madison Wisconsin, 1980 Michael Jack Rosherg. University Microfilm Intemational. Ann Arbor, 1982, 301 págs. 6 ils. 40 cuadros.

  5. Andres Ehin tähistas sünnipäeva raamatuesitlusega / Maire Kõrver

    Index Scriptorium Estoniae

    Kõrver, Maire, 1961-

    2006-01-01

    Andres Ehin esitles oma luulekogu "Põdrapõrnikapääsukene" ja selle ingliskeelset tõlget "Moose Beetle Swallow" oma sünnipäeval Iiri suursaadiku residentsis, kus oli kohal ka luulekogu tõlkija, Iiri luuletaja Patrick Cotter

  6. SUTD-i koorik = SUTD Gridshell / Andres Sevtšuk, Raul Kalvo

    Index Scriptorium Estoniae

    Sevtšuk, Andres, 1981-

    2013-01-01

    Singapuri Tehnoloogia ja Disaini Ülikooli (SUTD) raamatukogu paviljon. Eskiis valmis esimese aasta üliõpilastele korraldatud töötoas. Algse ideega töötas edasi City Form Lab (arhitektid Andres Sevtšuk, Raul Kalvo). Paviljon pandi kokku ligi saja üliõpilase osalusel. Valmis: mai 2013

  7. "Riigikogu hoone 90" = "Estonian parliament building 90" / Janno Roos, Andres Labi

    Index Scriptorium Estoniae

    Roos, Janno, 1976-

    2013-01-01

    Eesti Sisearhitektide Liidu 2012. aasta näituse kujunduse preemia pälvinud näitusest (Lossiplats 1A). Kujunduse autorid Janno Roos ja Andres Labi (Ruumilabor). Kuraator Mait Väljas. Graafiline disain: Identity. Sisearhitekti ja ESLi aastapreemiate žürii liikme Mari Kurismaa ning arhitektuuriajaloolase Leele Välja arvamused

  8. Abjeção em textos de André Sant’Anna

    Directory of Open Access Journals (Sweden)

    Leandro Salgueirinho

    2009-07-01

    Full Text Available Trata-se de uma leitura de textos do escritor André Sant’Anna a partir da problematização que, em The Return of the Real (1986, o crítico de arte norte-americano Hal Foster faz da noção de abjeto e da dita abject art.

  9. Andres Herkel : Venemaa esindaja ENPA presidendiks ei sobi / Haldi Ellam, Ravil Khair Al-Din

    Index Scriptorium Estoniae

    Ellam, Haldi

    2007-01-01

    Vene ajalehe Kommersant väitel on Eesti parlamendi süüdistused ENPA presidendi Rene van der Lindeni vastu seotud Mihhail Margelovi võimaliku valimisega uueks presidendiks. Kristiina Ojuland ja Andres Herkel lükkavad väite tagasi

  10. Miocene and Pleistocene mollusks from San Andres Island (Caribbean Sea, Colombia) and Paleogeographic considerations

    International Nuclear Information System (INIS)

    Diaz M, Juan Manuel; Garcia Llano, Cesar Fernando

    2010-01-01

    San Andres Island is the largest emerged portion of the oceanic archipelago of San Andres and Providencia, southwestern Caribbean Sea; it originated as a coralline atoll during Miocene times. The central and highest part of the island consists of a calcareous crest, the San Andres Formation, formed by Neogene lagoonal and reefal deposits. This crest is surrounded by a calcareous platform of Pleistocene age (San Luis Formation) which emerges only along the island coast, whereas its most part is submerged and covered by a Recent reef complex. Fossil material of molluscs from these two formations was collected in various sites throughout the island and taxonomically identified. In the four sites sampled in the San Andres Formation, material belonging to 19 gastropod and 37 bivalve species was obtained, most of them relatively well represented in other geologic formations of the Caribbean region that are stratigraphically situated between the upper Miocene and the middle Pliocene. Some elements occurring in this formation, such as Ostrea haitiensis, Meretrix dariena and Siphocypraea henekeni, were widely distributed in the Caribbean Miocene Province. In the San Luis Formation, material belonging to 18 gastropod and 11 bivalve species was obtained, most of them also represented in the Recent molluscan fauna of the region. The estimated age of this formation is Sangamonian, hence corresponding to similar formations occurring in Grand Cayman, Jamaica, Hispaniola, the Netherlands Antilles and other Caribbean islands, with which it also shows a great similarity in the composition of the molluscan fauna.

  11. Who Is DeAndre? Tapping the Power of Popular Culture in Literacy Learning

    Science.gov (United States)

    Gainer, Jesse

    2008-01-01

    Gainer talks about the importance of connecting students' background knowledge, experiences, and interests to curricular goals. He highlights the voice of DeAndre, an eighth-grade boy in special education classes, whose participation in an after-school club led to the creation of a video. According to Gainer, "[W]hen given the opportunity to…

  12. [Rets. rmt. : Glucksmann, Andre. Ouest contre Ouest. Pariis, 2003] / Malle Talvet

    Index Scriptorium Estoniae

    Talvet, Malle

    2004-01-01

    Prantsuse filosoofi Andre Glucksmanni raamat "Ouest contre Ouest" ehk "Lääs Lääne vastu" käsitleb rahvusvahelisi sündmusi 2002/2003, eelkõige Iraaki, terrorismi, Ameerika Ühendriike ja Prantsusmaad

  13. El naturalista Alejando de Humboldt, Cavanilles y Juan Andrés

    Directory of Open Access Journals (Sweden)

    María-Rosario MARTÍ MARCO

    2009-11-01

    Full Text Available RESUMEN: Tras una breve introducción en la que se traza un paralelismo entre el erudito Juan Andrés y el naturalista Alejandro de Humboldt, se presenta una síntesis de la relevancia del viaje científico de Humboldt iniciado en España. Las referencias sobre la figura y trabajo de Humboldt y, en menor medida, sobre Cavanilles en la gran obra total de Andrés demuestran el vigor intelectual de éste, quien subraya muchos de los elementos fundamentales del legado humboldtiano.ABSTRACT: This paper begins with a brief introduction to the similarities between the scholar Juan Andrés and the naturalist Alexander von Humboldt and continues with a summary of the relevance of Humboldt’s scientific expedition which began in Spain. The references to Humboldt’s persona and endeavours, and to a lesser extent to Cavanilles, in all of Andrés’ great works demonstrate the intellectual ability of the author who pinpoints many of the fundamental aspects of Humboldt’s legacy.

  14. Exploration, Invention and Imagination: The Myth of Icarus in André Bazin

    NARCIS (Netherlands)

    Joret, B.; Viegas, S.; Teixeira, M.T.

    2015-01-01

    In this essay, I intend to elucidate the ontological implications of André Bazin’s integral realism: "a recreation of the world in its own image." The connection that he draws between the world and the image is in harmony with his mythical project for cinema, which argues that an imaginative myth

  15. Giving Voice: Narrating silence, history and memory in André Brink ...

    African Journals Online (AJOL)

    This essay examines André Brink's two most recent novels, The Other Side of Silence (2002) and Before I Forget (2004), in terms of their voicing of silence and the rewriting of history and memory. Each has a theme familiar to Brink's readers – an historical story of colonial violence and violation avenged; and the recounting ...

  16. Baltoscandal on lõppenud, uued mõtted on saadud / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Eesti teater oli Baltoscandalil koondatud olematu teatri mõiste alla. Andres Noormetsa "Reunioon", Mart Kangro ja Ansambel U "Mäng", Marco Laimre "Vangistus", Asko Künnapi "Säälpool jõge", Anders Härmi "Cooking and Shitting", Sven Kuntu "Miks Eesti mehed ei tantsi?", Linnar Priimäe "Inimese lõhn"

  17. Perekonnad hoiavad kontrolli tuntud suurfirmade tegevuse üle / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2005-01-01

    Andres Haamer räägib oma perefirma Overall Eesti loomisest. Uniprindi-Unipressi omanikud Sirje ja Andrus Reinsoo hindavad koos oma äri peatrumpideks täielikku usaldust ja teineteisemõistmist. Lisad: Maailma legend: Rockefellerid; Eesti legend: Puhkid

  18. Shielding for Scattered Radiation to the Testis During Pelvic Radiotherapy: Is it worth?

    International Nuclear Information System (INIS)

    NAZMY, M.S.; El-Taher, M.M.; Attalla, E.M.; El-Hosiny, H.A.; Lotayef, M.M.

    2007-01-01

    To assess the value of external shielding of the testis during pelvic radiotherapy. Material and Methods: Nineteen patients, receiving radiotherapy to the pelvis with the lower border of the field at the obturator foramen, were randomly selected. A 5 half value layer cerro bent shield was positioned at the inferior border of the field. The dose to the testis was measured with and without the shield. Observations were made regarding the reflex cre master contraction and phantom measurements were done at different distances from the perineum. Results: The mean radiation dose to the testis for patients receiving treatment with no shield was 7.4 cGy (±) and it was 5.7c Gy (±) for patients with external shield, this difference was statistically significant by the paired t test p<0.0001. This accounted for a 22% decrease in the dose received by the testis. The position of the testis with the contraction of the cre master muscle and the dartos fascia after manipulation of the testis during diodes placement changed up to 3.5 cm (mean 1.5). Phantom measurements showed 37% increase in the dose with 2 cm change in the position of the testis to the pelvic direction. Conclusion: External shield at the inferior border of the pelvic field is a simple, easy reproducible, convenient shielding method. Clam-shell scrotal shield is not free of drawbacks, but still its benefits overweigh its harms and should be used with caution

  19. The oligosaccharidic content of the glycoconjugates of the prepubertal descended and undescended testis: lectin histochemical study.

    Science.gov (United States)

    Gheri, Gherardo; Sgambati, Eleonora; Thyrion, Giorgia D Zappoli; Vichi, Debora; Orlandini, Giovanni E

    2004-01-01

    The saccharidic content of the glycoconjugates has been studied in the descended the undescended testes of a 8 years old boy. For this purpose, a battery of seven HRP-conjugated lectins (SBA, DBA,PNA,WGA,UEAI, LTA and ConA) was used. D-galactose-N-acetyl-D-galactosamine and alpha-L-fucose sugar residues, which were present in the cytoplasm of the Sertoli cells of the normally positioned prepubertal testis, were not detected in the same cells of the undescended testis. The Leydig's cells of the descended testis appeared characterized by N-acetyl-D-glucosamine which was absent in the rare and atrophic Leydig's cells of the cryptorchid testis. Differences in sugar residues distribution between the descended and the undescended testis were also detected in the lamina propria of the seminiferous tubules. Peritubular myoid cells in the undescended testis only reacted with PNA, after neuraminidase digestion, thus revealing the presence of D-galactose (beta1-->3)-N-acetyl-D-galactosamine and sialic acid. In this study a complete distributional map of the sugar residues of the glycoconjugates in the descended and undescended prepubertal testis is reported.

  20. Findings concerning testis, vas deference, and epididymis in adult cases with nonpalpable testes

    Directory of Open Access Journals (Sweden)

    Coskun Sahin

    2011-12-01

    Full Text Available In this study, we aimed to state the relationship between testis, epididymis and vas deference, in adult cases with nonpalpable testis. Between January 1996 and December 2009, we evaluated 154 adult cases with nonpalpable testes. Mean age was 23 years (20-27 years. Explorations were performed by open inguinal incision, laparoscopy, and by inguinal incision and laparoscopy together on 22, 131 and 1 patient, respectively. Of all the unilateral cases, 32 were accepted as vanishing testis. In five of these cases, vas deference was ending inside the abdomen, and in the others, it was ending inside the scrotum. In the remaining 99 unilateral and 22 bilateral cases, 143 testes were found in total. Testes were found in the inguinal canal as atrophic in one case, at the right renal pedicle level with dysmorphic testis in one case, and anterior to the internal ring between the bladder and the common iliac vessels at a smaller than normal size in 119 cases. One (0.69% case did not have epididymis. While epididymis was attached to the testis only at the head and tail locations in 88 (61.53% cases, it was totally attached to the testis in 54 (37.76% cases. There is an obviously high incidence rate of testis and vas deference anomalies, where epididymis is the most frequent one. In cases with abdominal testes, this rate is highest for high localised abdominal testes.

  1. Anatomy and histology of the scrotal ligament in adults: inconsistency and variability of the gubernaculum testis.

    Science.gov (United States)

    Cavalie, G; Bellier, Alexandre; Marnas, G; Boisson, B; Robert, Y; Rabattu, P Y; Chaffanjon, P

    2018-04-01

    The anatomy of gubernaculum testis (GT) is often discussed; however, the postnatal anatomy of the GT or scrotal ligament (SL) is rarely described. Hence, we performed an anatomical and histological study to analyze histologically the structures between testis and scrotum. We performed anatomical dissections on 25 human fresh cadavers' testes. Each testis was removed with its envelopes and macroscopically analyzed. Then samples were included for histological study. Finally, they were analyzed under microscope, looking for attachments between testis, epididymis and scrotal envelopes. The absence of proximal and distal attachment was found in 56.0% of cases. Looking at the proximal attachment of the SL, the main one found is the epididymal attachment (28.0%), whereas no cases of testis attachment was found. Distally, there are more variations with scrotal attachment (12%) and cremaster attachment (12.0%). We found a significant prevalence of multiple adherences in 16.0% of cases too. Finally, in 15 cases (57.7%) an attachment is present between testis and epididymis, as it is commonly described. In the majority of cases there is no attachment of the lower pole of the testis and epididymis and these structures remain free. So it seems that the SL disappears with aging. Moreover, there is not only one kind of ligamentous attachment, but a high variability of attachments at the lower pole of the testiculo-epididymal structure. When it exists, this structure is never a real ligament and it seems more appropriate to use the term "attachments".

  2. Aproximación a la historia del derecho de autor: antecedentes normativos

    Directory of Open Access Journals (Sweden)

    Jhonny Antonio Pabón Cadavid

    2009-11-01

    Full Text Available La protección jurídica a las obras literarias y artísticas se institucionalizó desde la aparición de la imprenta. Antes del sistema de derecho de autor que conocemos hoy en día, existió un modelo de privilegios de carácter administrativo que se encuadra en el derecho público, para luego dar paso a la institución denominada propiedad literaria, del derecho privado. Este estudio examina la evolución que ha tenido la protección a las obras del espíritu teniendo en cuenta las condiciones determinantes en la difusión, transformación y recepción de las diferentes concepciones jurídicas cuyo objeto de protección fueron las obras y los impresos. Se estudia el desarrollo de los modelos de protección en Europa, para visualizar su posterior desplazamiento hacia América en el periodo postindependentista, con especial énfasis a la recepción latinoamericana en la primera mitad del siglo XIX evidenciando diversos modelos de protección circunscritos a los diferentes proyectos filosóficos políticos de las nuevas repúblicas americanas. Se destaca en particular la participación del colombiano JOSÉ MARÍA TORRES CAICEDO en la formación del Convenio de Berna y, en contraste, la existencia en Colombia de un modelo de privilegios de tradición inglesa, similar al Estatuto de la reina Ana de 1710, que permaneció vigente hasta finales del siglo XIX.

  3. Recurrence of acute myeloid leukemia in cryptorchid testis: case report

    International Nuclear Information System (INIS)

    Góes, Luccas Santos Patto de; Lopes, Roberto Iglesias; Campos, Octavio Henrique Arcos; Oliveira, Luiz Carlos Neves de; Sant'Anna, Alexandre Crippa; Dall'Oglio, Marcos Francisco; Srougi, Miguel

    2014-01-01

    A 23-year-old male with a history of bone marrow transplant for acute myeloid leukemia. He presented a large mass in the right inguinal region 5 years ago. Upon physical examination, right-sided cryptorchidism was observed. The tumor markers alpha-fetoprotein and beta-HCG were within normalcy range and lactate dehydrogenase was raised. Computed tomography of the abdomen and pelvis revealed right testicular mass in contiguity with the inguinal canal to the ipsilateral retroperitoneum, associated with right hydronephrosis. Due to the risk of germ-cell tumor in undescended testicle, the patient underwent radical right orchiectomy. The pathological examination showed recurrence of acute myeloid leukemia in the testis. He was referred to oncology for adjuvant therapy. Our literature review found no similar cases described

  4. Aspiration biopsy of testis: another method for histologic examination

    International Nuclear Information System (INIS)

    Nseyo, U.O.; Englander, L.S.; Huben, R.P.; Pontes, J.E.

    1984-01-01

    The most important method for evaluating the pathogenesis of male infertility is open testicular biopsy. Herein the authors describe a method of aspiration biopsy of testis for histologic examination. Sexually mature dogs and rats treated with chemotherapeutic agents and ionizing radiation were followed with periodic testicular aspiration biopsy during and after treatment. The histologic findings from the aspiration biopsy compare with the results of routine histologic examination in assessing spermatogenetic activity and delineating pathologic changes. The puncture in the experimental animals was performed under general anesthesia. In human patients testicular biopsy could be done under local anesthesia in an outpatient clinic. The procedure would be less painful, minimally invasive, and more cost-effective

  5. Testis cancer. Ichthyosis constitutes a significant risk factor

    DEFF Research Database (Denmark)

    Lykkesfeldt, G; Bennett, P; Lykkesfeldt, A E

    1991-01-01

    Testis cancer and ichthyosis are both relatively rare diseases. Hence the finding of six individuals with both these conditions in a small population with testicular cancer is highly conspicuous and indicates some kind of connection among such persons. Despite the identical clinical appearances...... of their ichthyoses, three of the ichthyotic subjects had no measurable activity of the enzyme, steroid sulfatase (STS) in leucocytes, a distinct characteristic of recessive X-linked ichthyosis (RXLI). However, the remaining three subjects had normal STS activity, a strong indicator of autosomal dominant ichthyosis...... (ADI). The STS activity in patients with testicular cancer who do not have ichthyosis (N = 30) was also within the normal range. The patients with testicular cancer with no skin disease had elevated serum levels of 4-androstenedione (4-AD), follicle stimulating hormone (FSH), and luteinizing hormone...

  6. Local Actions of Melatonin in Somatic Cells of the Testis.

    Science.gov (United States)

    Frungieri, Mónica Beatriz; Calandra, Ricardo Saúl; Rossi, Soledad Paola

    2017-05-31

    The pineal hormone melatonin regulates testicular function through the hypothalamic-adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular growth, proliferation, energy metabolism and the oxidation state, and consequently may regulate spermatogenesis. These data pinpoint melatonin as a key player in the regulation of testicular physiology (i.e., steroidogenesis, spermatogenesis) mostly in seasonal breeders. In patients with idiopathic infertility, melatonin exerts anti-proliferative and anti-inflammatory effects on testicular macrophages, and provides protective effects against oxidative stress in testicular mast cells. Consequently, melatonin is also involved in the modulation of inflammatory and oxidant/anti-oxidant states in testicular pathology. Overall, the literature data indicate that melatonin has important effects on testicular function and male reproduction.

  7. Recurrence of acute myeloid leukemia in cryptorchid testis: case report

    Energy Technology Data Exchange (ETDEWEB)

    Góes, Luccas Santos Patto de [Hospital do Servidor Público Municipal de São Paulo, São Paulo, SP (Brazil); Lopes, Roberto Iglesias [Hospital do Servidor Público Municipal de São Paulo, São Paulo, SP (Brazil); Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Campos, Octavio Henrique Arcos [Hospital do Servidor Público Municipal de São Paulo, São Paulo, SP (Brazil); Oliveira, Luiz Carlos Neves de; Sant' Anna, Alexandre Crippa; Dall' Oglio, Marcos Francisco; Srougi, Miguel [Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2014-07-01

    A 23-year-old male with a history of bone marrow transplant for acute myeloid leukemia. He presented a large mass in the right inguinal region 5 years ago. Upon physical examination, right-sided cryptorchidism was observed. The tumor markers alpha-fetoprotein and beta-HCG were within normalcy range and lactate dehydrogenase was raised. Computed tomography of the abdomen and pelvis revealed right testicular mass in contiguity with the inguinal canal to the ipsilateral retroperitoneum, associated with right hydronephrosis. Due to the risk of germ-cell tumor in undescended testicle, the patient underwent radical right orchiectomy. The pathological examination showed recurrence of acute myeloid leukemia in the testis. He was referred to oncology for adjuvant therapy. Our literature review found no similar cases described.

  8. Screening for carcinoma in situ of the contralateral testis in patients with germinal testicular cancer

    DEFF Research Database (Denmark)

    Berthelsen, J G; Skakkebaek, N E; von der Maase, H

    1982-01-01

    Two hundred and fifty biopsy specimens from the contralateral testis in patients with unilateral germinal testicular cancer were analysed by light microscopy for carcinoma-in-situ changes. Changes were found in 13 (5.2%) patients. One-third of patients with an atrophic contralateral testis (volume...... of cryptorchidism or both had been screened. Since the natural course of carcinoma in situ in the contralateral testis of patients with germinal testicular cancer has not been established, the patients are being re-evaluated frequently. To date two patients with carcinoma in situ have developed a second cancer....

  9. Montage, Militancy, Metaphysics: Chris Marker and André Bazin

    Directory of Open Access Journals (Sweden)

    Sarah Cooper

    2010-01-01

    Full Text Available

     

    Abstract (E: This article focuses on the relationship between the work of André Bazin and Chris Marker from the late 1940s through to the late 1950s and beyond. The division between Bazin's ŘRight Bankř affiliation with Les Cahiers du Cinéma on the one hand, and Markerřs ŘLeft Bankř allegiances on the other, is called into question here as my argument seeks to muddy the waters of their conventional ideological separation across the river Seine. Working alliteratively through Markerřs well-known talent for deft montage along with his militancy, I consider Bazinřs praise for Markerřs editing technique Ŕ in spite of famously expressing a preference elsewhere for the long take, and deep focus cinematography Ŕ and I address their political differences and convergences. Yet I also explore the rather more unexpected question of metaphysics in order to further emphasize a closer relationship between these two figures. I chart the emergence of an enduring spiritual bond between critic and filmmaker that surfaces first in Markerřs writings for the left-wing Catholic journal L’EspritMiranda: cultura griega, estudios clásicos, relación con Andrés Bello

    Directory of Open Access Journals (Sweden)

    Miguel Castillo Didier

    2005-12-01

    Full Text Available Francisco de Miranda (1750-1816, precursor, herói e mártir da Independência da América Hispânica, estudou a língua grega e reuniu uma vasta biblioteca, com mais de 170 autores gregos. A idéia de liberdade para a américa espanhola surgiu nele em 1781, ligada a sua profunda admiração pela Grécia, na qual nasceu a liberdade. Aí está porque em sua longa viagem através da Europa, em 1786, apesar das ameaças e dos perigos, ele viajou para a Grécia, que gemia sob a dominação otomana. Ele desejava conhecer os lugares onde haviam nascido as idéias de liberdade e democracia, onde um pequeno povo havia vencido um gigantesco império absolutista. Miranda visitou o Pireu, Atenas, Corinto, Salamina, Maratona e depois Esmirna e Constantinopla. Escreveu um jornal muito interessante de sua viagem à Grécia. Em 1792, Miranda serviu na França, quando a Revolução Francesa ainda não tinha abandonado os ideais libertários. Lá, Miranda defendeu os princípios republicanos e a divisão dos poderes, invocando não Montesquieu, mas o exemplo da Grécia antiga. Pedro Grase iniciou com Miranda seu estudo da tradição humanista na América Latina e prossegue com Andrés Bello (1781-1816, o grande sábio que estudou a língua grega na biblioteca de Miranda, em Londres, e que se tornou latinista e helenista. Bello compartilha de sua convicção de que o estudo do latim e do grego e da cultura clássica está na base de toda a cultura sólida.

  10. Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche.

    Science.gov (United States)

    Jørgensen, A; Young, J; Nielsen, J E; Joensen, U N; Toft, B G; Rajpert-De Meyts, E; Loveland, K L

    2014-05-13

    Testicular germ cell tumours of young adults, seminoma or non-seminomas, are preceded by a pre-invasive precursor, carcinoma in situ (CIS), understood to arise through differentiation arrest of embryonic germ cells. Knowledge about the malignant transformation of germ cells is currently limited by the lack of experimental models. The aim of this study was to establish an experimental tissue culture model to maintain normal and malignant germ cells within their niche and allow investigation of treatment effects. Human testis and testis cancer specimens from orchidectomies were cultured in 'hanging drops' and effects of activin A and follistatin treatment were investigated in seminoma cultures. Testis fragments with normal spermatogenesis or CIS cells were cultured for 14 days with sustained proliferation of germ cells and CIS cells and without increased apoptosis. Seminoma cultures survived 7 days, with proliferating cells detectable during the first 5 days. Activin A treatment significantly reduced KIT transcript and protein levels in seminoma cultures, thereby demonstrating a specific treatment response. Hanging drop cultures of human testis and testis cancer samples can be employed to delineate mechanisms governing growth of normal, CIS and tumorigenic germ cells retained within their niche.

  11. GPR56 is essential for testis development and male fertility in mice.

    Science.gov (United States)

    Chen, Guangchun; Yang, Liquan; Begum, Shahinoor; Xu, Lei

    2010-12-01

    Testis development is critical for male fertility and continuation of the mammalian species. Essential structural components of testes are seminiferous tubules, which are lined by Sertoli cells and provide nutrients and physical protection for the maturation of sperm. Seminiferous tubule formation is initiated in embryos as testis cords and relies on their remodeling for maturation during development. Recently, three-dimensional image analyses showed that testis cords in different parts of embryonic gonads undergo distinct remodeling processes. How this asymmetric remodeling is regulated has not been investigated. We report here that the absence of an adhesion G protein-coupled receptor, GPR56, leads to partial disruption of seminiferous tubules and reduced fertility in male mice. The defects appear to originate asymmetrically in embryonic gonads, but subsequent to the initial establishment of testis cords, suggesting that GPR56 might act to establish a spatial and/or temporal cue for asymmetric cord remodeling during male gonad development. © 2010 Wiley-Liss, Inc.

  12. Expression and Location of Glucose-regulated Protein 78 in Testis and Epididymis

    Directory of Open Access Journals (Sweden)

    W Wang

    2014-04-01

    Full Text Available Objective: To know the role of glucose-regulated protein 78 (GRP78/BiP/HSPA5 in spermatogenesis and its expression and location in the testis and epididymis. Methods: Immunohistochemistry and Western blot were used to detect GRP78 location and expression in the testis and epididymis. Results: Glucose-regulated protein 78 was observed in spermatocytes, round spermatids and interstitial cells of the testis and in principal cells of the epididymis. Glucose-regulated protein 78 was first detected in the rat testis at postnatal day 14. Thereafter, the protein level increased gradually with age and was maintained at a high and stable state after postnatal day 28. In the rat, GRP78 was expressed in the principal cells but not in clear cells of the epididymis. Conclusion: Glucose-regulated protein 78 participates in the process of spermatogenesis.

  13. Radiation effects of electromagnetic pulses on mouse blood-testis barrier

    International Nuclear Information System (INIS)

    Hou Wugang; Zhao Jie; Zhang Yuanqiang

    2005-01-01

    Radiation effects caused by 100 kV/m and 400 kV/m electromagnetic pulse (EMP) irradiations on mouse blood-testis barrier were studied by means of routine HE staining, Lanthanum traced electron microscope and injection of caudal vein with Evans Blue. The EMP irradiation of different dose rates damaged Sertoli's cell and blood-testis barrier of mouse testis in different levels. Severe injuries were observed with the 400 kV/m irradiation group, with apoptosis and necrosis in a large quantity of the spermatogenic cells, shape and structural changes of the Sertoli's cells, and serious injuries to the blood-testis barrier, one day after the irradiation. The basal compartment separated from the adluminal compartment in most of the VIII stage seminiferous epithelium, and a great number of apoptosis and necrosis spermatogenic cells were released into the cavities. Injuries of blood-testis barrier could be observed 21 days after the 400 kV/m irradiation. The injuries of 100 kV/m irradiation groups were less severe than the 400 kV/m groups, in which the damages to the Sertoli's cells, the seminiferous epithelium and blood-testis barrier recovered to some extent 14 days after the irradiation. The authors conclude that EMP irradiation can damage mouse blood-tests barrier. The injuries, and the time for recovery, are related to EMP power intensity. (authors)

  14. El autor ante sus lectores en el siglo XVII: el vértigo de la imprenta

    Directory of Open Access Journals (Sweden)

    Pedro Ruiz Pérez

    2015-12-01

    Full Text Available La imprenta, como cualquier otra tecnología, responde a unas demandas y produce un impacto en la ideología y el sistema de valores. En este caso afecta directamente a la posición de los autores, en su propia concepción, pero también en la relación con el texto y sus lectores. Entre el rechazo y la atracción, el efecto de la imprenta se traduce en un vértigo con directas manifestaciones en los textos y, sobre todo, en las declaraciones paratextuales. Se propone un acercamiento centrado de manera particular en la narrativa del siglo XVII, por su particular vinculación con la imprenta, distinta de la que mantenían la lírica o el teatro, y por los procesos de profesionalización de los autores que se dan en su espacio.

  15. ¿ES LEGÍTIMA LA PROTECCIÓN PENAL DE LOS DERECHOS MORALES DE AUTOR?

    Directory of Open Access Journals (Sweden)

    César Alejandro Osorio Moreno

    2010-11-01

    Full Text Available En el contexto del derecho penal moderno y desde una perspectiva comparada entre el derecho penal español y el derecho penal colombiano en cuanto a la protección penal de los derechos morales de autor, se pone en discusión si es necesaria la intervención penal o no, a partir de cuestionar si en verdad se protege un bien jurídico relevante que ameritaría el mecanismo de control social más grave del que dispone el Estado que es el derecho penal, o cómo se planteará, si a partir de la protección de los derechos patrimoniales de autor se cobijan los morales tal como acontece en España en la actualidad.

  16. Aproximació a l'univers fílmic de Wes Anderson: existeix una marca autoral?

    OpenAIRE

    Cadena Hernández, Adrià

    2016-01-01

    Al llarg del anys Wes Anderson s'ha postulat com un dels directors contemporanis més importants i influents. Aquest estudi revisa la totalitat de la seva filmografia, centrant-se en la seva última pel·lícula "The Grand Budapest Hotel". L'anàlisi pretén verificar si Wes Anderson pot ser considerat o no autor de les seves pel·lícules en base a les pautes estipulades per la política d'autors provinent de la Nouvelle Vague. A lo largo de los últimos años Wes Anderson se ha postulado como uno d...

  17. Telefilm toob venelasteni Solzhenitsõni Gulagi-romaani / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    Vene telekanal hakkab näitama Gleb Panfilovi uut teleseriaali Aleksandr Solzhenitsõni "Esimeses ringis" järgi, kus kirjanik on stsenaariumi autor ja loeb ka kaadritagust jutustavat teksti. Peaosas Jevgeni Mironov

  18. Jäneda viimane mõisaproua ilmus eestlase ette / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2011-01-01

    Jänedal Pulli tallis 1. juulil esietendunud Hendrik Toompere noorema lavastusest "Pärast surma Jendalis" (MTÜ R.A.A.A.M). Autor: Urmas Lennuk, osades: Merle Palmiste, Rain Simmul, Sulev Teppart, Marta Laan, Hendrik Toompere noorim

  19. A Natureza e a gênese das Minas do Sul nos livros de André João Antonil e Sebastião da Rocha Pita

    Directory of Open Access Journals (Sweden)

    Francisco Eduardo de Andrade

    2006-06-01

    Full Text Available Este artigo trata do sentido cosmológico da Natureza, em voga na época das representações do barroco (séculos XVII e XVIII, quando aplicado ao contexto novo da América portuguesa com o descobrimento das Minas de ouro. Dois autores da Bahia foram significativos das primeiras visões de Natureza e da sociedade das Minas do ouro: André João Antonil e Sebastião da Rocha Pita. Ambos produziram obras sobre a gênese do espaço minerador, buscando, de algum modo, integrá-lo a uma história providencial da colonização portuguesa. Para isso, investiram em temas e imagens que, além de condicionados por evidentes interesses políticos e econômicos dos plantadores do litoral, refletem os vínculos discursivos dos coloniais eruditos.This work deals with the cosmological sense of the Nature, which has been intensively studied at the time of baroc representations (17th and 18th centuries, applied to the Portuguese America new context of gold mines discoveries. Two authors from Bahia were very important to the early views on the Nature and on the society in gold mines: André João Antonil and Sebastião da Rocha Pita. Both have made studies about the genesis of the mining space in such a way to integrate it in an opportune history of the Portuguese colonization. To do this, they dealed mainly with subjects and images which reveal discourse links of colonial wise persons, and also which were influenced by political and economical interests of the coastal farmers.

  1. Séminaire de probabilités XXXIX in memoriam Paul-André Meyer

    CERN Document Server

    Yor, Marc

    2006-01-01

    The 39th volume of Séminaire de Probabilités is a tribute to the memory of Paul André Meyer. His life and achievements are recalled; homages are rendered by his friends and colleagues. This volume also contains mathematical contributions to classical and quantum stochastic calculus, the theory of processes, martingales and their applications to mathematical finance, Brownian motion. They provide an overview on the current trends of stochastic calculus.

  2. Sexualcoercion: Woman Subordination Undergone By Hanna X In Andre Brink's The Otherside Of Silence Novel

    OpenAIRE

    NUSANTI, RIHAN

    2014-01-01

    Nusanti, Rihan. 2014. “Sexual Coercion: Woman Subordination Undergoneby Hanna X in Andre Brink's The Otherside of Silence novel”. Study Programof English, Department of Languages and Literature, Faculty of Cultural Studies,Universitas Brawijaya. Supervisor: Fariska Pujiyanti, M.Hum; Co-supervisor: Winda Candra Hantari,M.A. Keywords: Feminist-Marxist, sexual coercion, patriarchy, women subordination,German women In traditional view, women occupy secondary position lower than men in society. It...

  3. Analysis of lichen species for atmospheric pollution biomonitoring in the Santo Andre municipality, Sao Paulo, Brazil

    International Nuclear Information System (INIS)

    Saiki, M.; Alves, E.R.; Marcelli, M.P.

    2007-01-01

    Instrumental neutron activation analysis was applied for the determination of trace elements in Canoparmelia texana species collected in nonpolluted areas of Atlantic Forest and in six sites of Santo Andre Municipality, SP, Brazil. Concentrations of As, Ba, Br, Ca, Cd, Cl, Cr, Cs, Co, Fe, K, La, Mn, Na, Rb, Sb, Sc, Se, U, and Zn were determined and comparisons were made between the results obtained in lichens from different sites

  4. Mesothelioma of the testis and nephrotic syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Bacchetta Justine

    2009-06-01

    Full Text Available Abstract Introduction Paraneoplastic glomerulopathies are rare manifestations of neoplastic disease to be distinguished from iatrogenic renal damage. Solid tumors are preferentially associated with membranous nephropathy, whereas Hodgkin's lymphomas are associated with minimal change disease. Case presentation We report a 63-year-old Caucasian male diagnosed with a mesothelioma of the tunica vaginalis testis who, secondary to this, also presented with a nephrotic syndrome due to minimal change disease. In the present case, the paraneoplastic etiology of the nephrotic syndrome can be discussed on four unusual elements: minimal change lesions were found; the glomerulopathy was very sensitive to corticosteroids; the nephrotic syndrome occurred 11 months after the diagnosis of the primary malignancy, but concomitantly with the recurrence; and the nephrotic syndrome did not decrease with tumor control and did not recur when the mesothelioma escaped treatment. No other etiologies could nevertheless explain this phenomenon. Conclusion Paraneoplastic nephrotic syndrome is often associated with membranous nephropathy in patients with solid tumors, especially in patients with lung and gastrointestinal tract neoplasia. The management of these patients is associated with a symptomatic treatment such as sodium and water restriction, diuretics and ACE inhibitors and a prophylaxis of specific complications of nephrotic syndrome including thromboembolism, infections and lipid abnormalities. Treatment of neoplasia must be undertaken rapidly, treatments must be regularly analyzed and drugs binding to albumin may be used with precaution.

  5. Cancer-testis antigen expression and immunogenicity in AL amyloidosis

    International Nuclear Information System (INIS)

    Rosenzweig, M A; Landau, H; Seldin, D; O'Hara, C; Girnius, S; Hanson, N; Frosina, D; Sedrak, C; Arcila, M; Comenzo, R L; Giralt, S; Gnjatic, S; Jungbluth, A A; Koehne, G

    2012-01-01

    Light-chain amyloidosis (AL) is a plasma cell dyscrasia closely related to multiple myeloma. In multiple myeloma, the cancer-testis antigens (CTAs) CT7 (MAGE-C1), CT10 (MAGE-C2) and MAGE-A CTAs are expressed in up to 80% of cases. In this study, we investigated the expression and immunogenicity of several CTAs in patients with AL amyloidosis in a total of 38 bone marrow specimens by employing standard immunohistochemistry techniques on paraffin-embedded archival tissues. Plasma samples from 35 patients (27 with matched bone marrow samples) were also analyzed by ELISA for sero reactivity to a group of full-length CTA proteins. CT7 was present in 25/38 (66%) while CT10 was demonstrated in 3/38 and GAGE in 1/38 AL amyloid cases. The expression pattern was mostly focal. There were no significant differences with regard to organ involvement, response to treatment, or prognosis in CTA positive compared to negative cases. None of the specimens showed spontaneous humoral immunity to CT7, but sero reactivity was observed in individual patients to other CTAs. This study identifies CT7 as the prevalent CTA in plasma cells of patients with AL amyloidosis. Further analyses determining the biology of CTAs in AL amyloidosis and their value as potential targets for immunotherapy are warranted

  6. Endocrine disrupting compounds exposure and testis development in mammals

    Science.gov (United States)

    Egbowona, Biola F.; Mustapha, Olajide A.

    2011-01-01

    In the last few decades, there is substantial evidence that male reproductive function is deteriorating in humans and wildlife and this is associated with unintentional exposure to widely used synthetic chemicals. Subsequently, much has been done to show that certain chemicals in the environment adversely interfere with the developing fetal gonads of the laboratory animals. Some in vitro studies have demonstrated treatment-induced reproductive problems in offspring exposed to endocrine disrupting compounds (EDC) which are similar to those observed in wildlife and human population. Few EDC studies have demonstrated that there are certain periods of gestation when the developing fetus is highly sensitive and at risk of small endocrine changes. Similar observations have been made in the sewage sludge model, however, while animal studies have been insightful in providing valuable information about the range of effects that can be attributed to in utero exposure to EDCs, varying levels of maternal doses administered in different studies exaggerated extrapolation of these results to human. Thus the EDC concentration representative of fetal exposure levels is uncertain because of the complexities of its nature. So far, the level of fetal exposure can only be roughly estimated. There is substantial evidence from animal data to prove that EDCs can adversely affect reproductive development and function in male and more has accumulated on the mechanisms by which they exert their effects. This paper therefore, reviews previous studies to highlight the extent to which testis development can be disrupted during fetal life. PMID:29255381

  7. Testicular function following irradiation of the human prepubertal testis

    International Nuclear Information System (INIS)

    Shalet, S.M.; Beardwell, C.G.; Jacobs, H.S.; Pearson, D.

    1978-01-01

    Testicular function was studied in ten men, aged between 17 and 36 years, who had received irradiation for a nephroblastoma during childhood. The dose of scattered irradiation to the testes ranged from 268 to 983 rad. Eight subjects had either oligo-or azoosperma (0 to 5.6 million/ml), seven of whom had an elevated serum follicle stimulating hormone (FSH) level. One subject showed evidence of Leydig cell dysfunction with a raised serum luteinizing hormone level (LH) and a low plasma testosterone concentration. A second group of eight prepubertal males, aged between 8 and 14 years, were studied. These had also been irradiated for abdominal malignancies during childhood and received a similar dose of irradiation to the testis as the first group studied. The plasma testosterone levels were within the normal range in all eight. The mean gonadotropin levels were not significantly different from normal. Thus irradiation-induced damage to the germinal epithelium in prepubertal boys raised FSH levels after puberty but not before it. The conclusion is that inhibin has a minor role in the control of the pre-pubertal hypothalmic-pituitary testicular axis and its contribution to gonadal control of gonadotrophin secretion changes with sexual maturation. (author)

  8. André B. Muller (25.9.1918-1.4.2006)

    Science.gov (United States)

    West, R. M.

    2006-06-01

    With great sadness, we have learned about the death of André Muller on 1 April, at the age of 87. Living in retirement in his native Holland since 1983, he was one of ESOs true pioneers, an outstanding representative of the select group of European astronomers who succeeded in steering ESO through the difficult initial phases. André was close-ly associated with the entire process, from the first site monitoring programmes in South Africa to the subsequent search in Chile, the decision in favour of the La Silla site, as well as the management of ESOs early activities in Chile, includ-ing the construction of the headquarters and observatory and the installation of the first generation of ESO telescopes. Few persons, if any, have been so inti-mately connected to the setting-up of ESOs facilities and it would be impossible to list in detail all of the services André performed for the organisation with such great expertise and zeal during his long career.

  9. “O Negro André”: a questão racial na vida e no pensamento do abolicionista André Rebouças

    Directory of Open Access Journals (Sweden)

    Anita Maria Pequeno Soares

    2017-08-01

    Full Text Available The main objective of this work was to analyze how the context of racial relations influenced the construction of the self and the intellectual production of black intellectual and abolitionist André Rebouças. Through primary sources, it was possible to recreate the process of “self construction” lived by André Rebouças as a black man who had African ancestry. It was possible to notice that some characteristics of his social thought became radical at the same time the self-recognition of his racial condition became deeper, during the period in which he was self-exiled from Brazil, immediately after the proclamation of the republic in 1889. During his life in Africa, he broke his silence about his racial reality. In this period, the construction of his self goes through a transformation, as he begins to see himself and to reaffirm himself as a black and African man. This awaken to “racial consciousness” was interpreted, like Mattos suggested (2010, inspired by the concept of “double consciousness”, elaborated by Du Bois and further developed by Paul Gilroy in “The Black Atlantic” (2012.

  10. De niet-scrotale testis: huidige standpunten van de Werkgroep Kinderurologie van de Nederlandse Vereniging voor Urologie [Undescended testis: Current views and advice for treatment

    NARCIS (Netherlands)

    Hack, W.W.M.; Sijstermans, K.; Voort-Doedens, L.M. van der; Meijer, R.W.; Heij, H.A.; Delemarre-van de Waal, H.A.; Pierik, F.H.

    2008-01-01

    Eerder dit jaar verschenen in dit tijdschrift drie artikelen gewijd aan de niet-scrotale testis (NST).1-3 Ze hebben tot veel discussie geleid binnen de Werkgroep Kinderurologie (WGKU) van de Nederlandse Vereniging voor Urologie (NVU), hetgeen resulteerde in dit commentaar. Vooral de artikelen van

  11. TORSION TESTIS : ROLE OF COLOR DOPPLER : A STUDY OF 50 CASES

    Directory of Open Access Journals (Sweden)

    Anand

    2015-09-01

    Full Text Available BACKGROUND: T orsion testis is one of the catast r ophic conditions in children and young a d u lts. Traditionally the diagnosis was made clinical presentation and suspicion. Critical decision making is essential to save the testis . OBJECTIVE: To study the usefu lness and efficacy of Doppler ultrasound in correctly diagnosing acute scrotal conditions in children and young adults to save the testis and to avoid negative explorations. METHODS: Over a period of two years 50 patients with acute scrotum were admitted i n general surgery department who underwent Doppler ultrasound scrotum and its efficacy in correctly diagnosing the pathology was analysed. RESULTS: 50 patients with age group <25 years were included in study. Scrotal pain was the most frequent presenting s ymptom of acute scrotum (98% followed by Swelling of the hemiscrolum on the involved side present in 86% of the patients. Doppler ultrasound showed torsion of testis in 18 patients. On Scrotal exploration, torsion of spermatic cord was confirmed in 16 pat ients, one patient had torsion of appendix of testis and the other had Epididymo - orchitis. Thus the sensitivity and specificity of Doppler ultrasonography for testicular torsion was 86.9% and 92.6% respectively. 2 patients with equivocal Doppler findings, but strong clinical suspicion of testicular torsion were explored, and testis was found to be torsed in both two patients. Doppler ultrasonography showed Epididymo - orchitis in 22 patients, torsion of testicular appendage in 2 patients, Idiopathic scrotal edema in one, and in 5 pts no significant pathology found. All twenty patients of epididymo - orchitis, two patients of torsion of testicular appendage, and one patient of idiopathic scrotal edema were managed conservatively. At three weeks follow up, all th e patients were free of symptoms. The sensitivity and specificity of Doppler ultrasonography for epididymo - orchitis was 95% and 100% respectively. CONCLUSIONS: color

  12. La piratería de derechos de autor y el desarrollo: evidencia de los Estados Unidos en el siglo XIX

    Directory of Open Access Journals (Sweden)

    Zorina Khan

    2008-06-01

    Full Text Available ¿La falta de derechos internacionales de autor beneficia o perjudica a los países en desarrollo? Este artículo examina los efectos de la piratería de derechos de autor en Estados Unidos durante un período cuando era un país en desarrollo. Las leyes estadounidenses protegían los derechos de autor de sus ciudadanos desde 1790, pero hasta 1891 consideraron que las obras de los ciudadanos extranjeros eran de dominio público. En 1891 se modificaron para que los extranjeros obtuvieran protección de derechos de autor si satisfacían ciertas condiciones. Este episodio de la historia estadounidense es útil para investigar las consecuencias de la piratería de derechos internacionales de autor. El análisis usa registros de derechos de autor, información de los autores, títulos y precios de los libros, datos financieros de los balances de una compañía editorial muy importante y demandas judiciales sobre cuestiones de derechos de autor para investigar los efectos de bienestar de la violación de las obras extranjeras sobre los editores, los autores y el público estadounidense. Los resultados indican que Estados Unidos se benefició con la piratería y que la elección del régimen de derechos de autor fue endógena al nivel de desarrollo económico.

  13. Busca de consenso entre o direito do autor e o acesso à informação pelo público na rede de computadores: uma ótica dos tratados relativos ao direito autoral

    Directory of Open Access Journals (Sweden)

    Patrícia Pereira Peralta

    Full Text Available A evolução da tecnologia da informação e comunicação tem possibilitado a inserção do conteúdo na rede de computadores. No entanto, tem-se criado divergência entre o direito do autor e o acesso à informação. Os tratados e acordos internacionais tentam minimizar essa divergência, mas a dinâmica dos agentes sobre a apropriação do conteúdo é complexa, a ponto das instituições nacionais não conseguirem abordar o objeto por inteiro.

  14. Is radiation-induced cell death in mouse testis apoptosis?

    International Nuclear Information System (INIS)

    Hasegawa, Masatoshi; Wilson, Gene; Yun Zhang; Russell, Lonnie D.; Meistrich, Marvin L.

    1996-01-01

    Purpose: Radiation-induced death of spermatogonia and other germ cells in the testis has been claimed to be by an apoptotic mechanism, but these processes have been incompletely characterized. We investigated irradiated mouse testis by multiple techniques to determine whether the mode of cell death of spermatogonia can be classified as apoptosis. Materials and Methods: Adult male C57BL/6 and p53 knockout mice were irradiated with single doses of 0.5, 2.5 or 5.0 Gy. Four, 6, 8, 12, 18 or 24 hours after irradiation, testes were fixed in Bouin's solution or in 10% formalin. Slides were stained with hematoxylin and eosin or TdT-mediated dUTP-biotin nick end labeling (TUNEL). Some testes were perfusion-fixed with 5% glutaraldehyde for electron microscopy. Gel electrophoresis of DNA was also performed to identify DNA fragmentation. The number of sperm heads was counted 29 days after irradiation to evaluate the effect of radiation on the eventual survival of the differentiated spermatogonia. Results: The earliest sign of histological damage was an increase in the numbers of abnormal spermatogonia in the seminiferous tubules, particularly in stage I-VI of the seminiferous epithelial cycle. The numbers of abnormal spermatogonia began to increase at 6 hours, reached a peak 12 hours after irradiation, and then declined. The total number of spermatogonia began to decrease at 12 hours after irradiation, resulting in a 60% decline in sperm produced 29 days after 0.5 Gy. Although changes were greatest following 5.0 Gy irradiation, even 0.5 Gy induced marked changes. However, these changes were not induced in p53 knockout mice. By both light and electron microscopy, spermatogonia showed some condensation of nuclear chromatin, but margination of chromatin with clear delineation and nuclear fragmentation was rare. Many of the abnormal spermatogonia showed a positive TUNEL reaction, which was also at a maximum at 12 hours after irradiation. In addition, some TUNEL-positive and

  15. Magnetization transfer imaging of normal and abnormal testis: preliminary results

    International Nuclear Information System (INIS)

    Tsili, Athina C.; Ntorkou, Alexandra; Maliakas, Vasilios; Argyropoulou, Maria I.; Baltogiannis, Dimitrios; Sylakos, Anastasios; Sofikitis, Nikolaos; Stavrou, Sotirios; Astrakas, Loukas G.

    2016-01-01

    The aim was to determine the magnetization transfer ratio (MTR) of normal testes, possible variations with age and to assess the feasibility of MTR in characterizing various testicular lesions. Eighty-six men were included. A three-dimensional gradient-echo MT sequence was performed, with/without an on-resonance binomial prepulse. MTR was calculated as: (SIo-SIm)/(SIo) x 100 %, where SIm and SIo refers to signal intensities with and without the saturation pulse, respectively. Subjects were classified as: group 1, 20-39 years; group 2, 40-65 years; and group 3, older than 65 years of age. Analysis of variance (ANOVA) followed by the least significant difference test was used to assess variations of MTR with age. Comparison between the MTR of normal testis, malignant and benign testicular lesions was performed using independent-samples t testing. ANOVA revealed differences of MTR between age groups (F = 7.51, P = 0.001). Significant differences between groups 1, 2 (P = 0.011) and 1, 3 (P < 0.001) were found, but not between 2, 3 (P = 0.082). The MTR (in percent) of testicular carcinomas was 55.0 ± 3.2, significantly higher than that of benign lesions (50.3 ± 4.0, P = 0.02) and of normal testes (47.4 ± 2.2, P < 0.001). MTR of normal testes decreases with age. MTR might be helpful in the diagnostic work-up of testicular lesions. (orig.)

  16. Effect of vitamin E supplement in diet on antioxidant ability of testis in Boer goat.

    Science.gov (United States)

    Hong, Zhu; Hailing, Luo; Hui, Meng; Guijie, Zhang; Leyan, Yan; Dubing, Yue

    2010-01-01

    The aim of this study was to evaluate the supplementation of Vitamin E in diet on the antioxidant capacity of testis in Boer goat. Twenty-four healthy, Boer male kids of similar body weight (BW) were selected at 3 months of age from the kid flock. Kids were born from does treated with simultaneous flushing and artificial insemination technology. The Boer kids were divided into four groups randomly, supplemented with 0, 80, 320 and 880 IU kid(-1)d(-1) Vitamin E, which were labeled as Groups 1, 2, 3 and 4, respectively, for 150 days (5 months). Blood samples were collected at the 15th-, 30th-, 60th-, 90th-, 120th-, and 150th-day during the experimental period, and the serums were used to determine Vitamin E content. Three Boer goats in each group were slaughtered at the age of eight months at the end of the experiment. Liver and testis were collected to test the Vitamin E content and the antioxidant capacity of testis. Results showed that the content of Vitamin E in serum, liver and testis increased with the increasing addition of Vitamin E. However, the content of Vitamin E in the serum, liver and testis, in the control, was significantly lower than in Groups 2 and 3, respectively, but there was no significant difference between the control Group and Group 4. When high levels of Vitamin E (880 IU kid(-1)d(-1)) were added, contents of Vitamin E in serum, liver and testis were decreased and compared with the controls. Adding a low level (80 IU kid(-1)d(-1)) of Vitamin E can increase activity of total anti-oxidation competence (T-AOC) and superoxide dismutase (SOD), and decrease content of nitric oxide (NO) in testis. MDA (malondialdehyde) content was decreased significantly in Group 3 (P<0.05). Supplementing a low level (80 IU kid(-1)d(-1)) and middle level (320 IU kid(-1)d(-1)) of Vitamin E decreased activity of nitric oxide syntha (NOS) in testis (P<0.05). Vitamin E can increase activity of GSH-PX (glutathione peroxidase). These results indicate that supplementing

  17. Radiation damage to mouse testis cells from [/sup 99m/Tc] pertechnetate

    International Nuclear Information System (INIS)

    Mian, T.A.; Suzuki, N.; Glenn, H.J.; Haynie, T.P.; Meistrich, M.L.

    1977-01-01

    The radiation dose and the biologic damage to mouse testis from intravenously administered [/sup 99m/Tc] pertechnetate were studied. The dose was measured for penetrating radiations from /sup 99m/Tc, using calibrated thermoluminescent dosimeters and calculations from the uptake of the nuclide in the testis, and was found to be 4.9 rads per mCi of 99 Tc. The biologic damage was measured by the decrease in the number of sperm heads in the testis, counted both by hemacytometer and by Coulter counter. In preliminary experiments using external gamma radiation from 137 Cs, the number of sperm heads reached a minimum 29 days after irradiation. Twenty-nine days after injection of 5.8 mCi of /sup 99m/Tc, which gives 28 rads to the testis, the number of sperm heads decreased to 70% of control. The biologic effect corresponds to that seen after 40 rads of gamma radiation from 137 Cs. The damage to mouse testis cells from internally administered /sup 99m/Tc as measured in an in vivo system appears to be at least as significant as that from external gamma irradiation, if not more so

  18. Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment.

    Science.gov (United States)

    Mohammadi, F; Nikzad, H; Taghizadeh, M; Taherian, A; Azami-Tameh, A; Hosseini, S M; Moravveji, A

    2014-08-01

    Decreasing the side effects of chemotherapy in testis has been the subjects of many studies. In this study, the protective effects of Zingiber officinale extract on rat testis were investigated after chemotherapy with cyclophosphamide. Histological and biochemical parameters were compared in cyclophosphamide-treated rats with or without ginger extract intake. Wistar male rats were randomly divided into four groups each 10. The control group received a single injection of 1 ml isotonic saline intraperitoneally. The Cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg(-1) BW) intraperitoneally. CP + 300 and CP + 600 groups received orally 300 or 600 mg of ginger extract, respectively, for a period of 6 weeks after cyclophosphamide injection. The morphologic and histological structure of the testis was compared in different groups of the rats. Also, factors like malondialdehyde, reactive oxygen species, total antioxidant capacity and testosterone level were assessed in blood serum as well. Our results showed that although ginger extract could not change testis weight, malondialdehyde (MDA) and ROS, but antioxidant and testosterone levels in serum were increased significantly. Also, an obvious improved histological change was seen in CP + 300 and CP + 600 groups in comparison with CP group. These protective effects of ginger on rat testis after cyclophosphamide treatment could be attributed to the higher serum level of antioxidants. © 2013 Blackwell Verlag GmbH.

  19. Biometric and Ultrasonographic Evaluation of the Testis of One-humped Camel (Camelus dromedarius

    Directory of Open Access Journals (Sweden)

    Riaz Hussain Pasha, Anas Sarwar Qureshi*, Laeeq Akbar Lodhi1 and Huma Jamil1

    2011-04-01

    Full Text Available Twenty four adult clinically healthy one-humped male camels (Camelus dromedarius were examined three times (beginning, mid and end in each season (winter, spring, summer and autumn for establishing the normal ultrasonic appearance and seasonal changes in the testicular parenchyma in the natural ecology of Punjab, Pakistan. The testes of each camel were scanned by using a B-mode real time ultrasound scanner fitted with a 7.5-MHz linear-array transducer. Scrotal biometry was done with the measuring tape during all the seasons of year. The tunics of the testes appeared as hyperechoic lines surrounding the homogenous, moderately echogenic parenchyma of the testis. The mediastinum testis was visualized as hyperechoic central line and a spot, in longitudinal and transverse sections, respectively. During winter season, the parenchyma was hyperechoic and mediastinum testis was seen as thin hyperechoic line. In spring, the echogenicity of parenchyma was moderate and mediastinum appeared relatively thick central hyperechoic line. In summer and autumn, less echoic parenchyma and thick band of mediastinum was recorded. Biometric studies showed significantly (P<0.01 higher scrotal length and width of the testis during winter and spring season as compared to summer and autumn. Present study revealed that the ultrasonic structure of camel testis resembles other mammals and season has an apparent effect on the testicular size and echogenicity of the testicular parenchyma in the one-humped camel.

  20. Transcriptome profiling of testis during sexual maturation stages in Eriocheir sinensis using Illumina sequencing.

    Directory of Open Access Journals (Sweden)

    Lin He

    Full Text Available The testis is a highly specialized tissue that plays dual roles in ensuring fertility by producing spermatozoa and hormones. Spermatogenesis is a complex process, resulting in the production of mature sperm from primordial germ cells. Significant structural and biochemical changes take place in the seminiferous epithelium of the adult testis during spermatogenesis. The gene expression pattern of testis in Chinese mitten crab (Eriocheir sinensis has not been extensively studied, and limited genetic research has been performed on this species. The advent of high-throughput sequencing technologies enables the generation of genomic resources within a short period of time and at minimal cost. In the present study, we performed de novo transcriptome sequencing to produce a comprehensive transcript dataset for testis of E. sinensis. In two runs, we produced 25,698,778 sequencing reads corresponding with 2.31 Gb total nucleotides. These reads were assembled into 342,753 contigs or 141,861 scaffold sequences, which identified 96,311 unigenes. Based on similarity searches with known proteins, 39,995 unigenes were annotated based on having a Blast hit in the non-redundant database or ESTscan results with a cut-off E-value above 10(-5. This is the first report of a mitten crab transcriptome using high-throughput sequencing technology, and all these testes transcripts can help us understand the molecular mechanisms involved in spermatogenesis and testis maturation.

  1. Trace elemental analysis in cancer-afflicted tissues of penis and testis by PIXE technique

    Energy Technology Data Exchange (ETDEWEB)

    Naga Raju, G.J. [Swami Jnanananda Laboratories for Nuclear Research, Andhra University, Visakhapatnam 530 003 (India); John Charles, M. [Swami Jnanananda Laboratories for Nuclear Research, Andhra University, Visakhapatnam 530 003 (India); Bhuloka Reddy, S. [Swami Jnanananda Laboratories for Nuclear Research, Andhra University, Visakhapatnam 530 003 (India)]. E-mail: sbr_r@yahoo.com; Sarita, P. [Swami Jnanananda Laboratories for Nuclear Research, Andhra University, Visakhapatnam 530 003 (India); Seetharami Reddy, B. [Swami Jnanananda Laboratories for Nuclear Research, Andhra University, Visakhapatnam 530 003 (India); Rama Lakshmi, P.V.B. [Pathology Department, Andhra Medical College, Visakhapatnam 530 002 (India); Vijayan, V. [Institute of Physics, Sachivalaya Marg, Bhubaneswar 751 001 (India)

    2005-04-01

    PIXE technique was employed to estimate the trace elemental concentrations in the biological samples of cancerous penis and testis. A 3 MeV proton beam was employed to excite the samples. From the present results it can be seen that the concentrations of Cl, Fe and Co are lower in the cancerous tissue of the penis when compared with those in normal tissue while the concentrations of Cu, Zn and As are relatively higher. The concentrations of K, Ca, Ti, Cr, Mn, Br, Sr and Pb are in agreement within standard deviations in both cancerous and normal tissues. In the cancerous tissue of testis, the concentrations of K, Cr and Cu are higher while the concentrations of Fe, Co and Zn are lower when compared to those in normal tissue of testis. The concentrations of Cl, Ca, Ti and Mn are in agreement in both cancerous and normal tissues of testis. The higher levels of Cu lead to the development of tumor. Our results also support the underlying hypothesis of an anticopper, antiangiogenic approach to cancer therapy. The Cu/Zn ratios of both penis and testis were higher in cancer tissues compared to that of normal.

  2. Rare presentation of a testicular angiofibroma treated with testis sparing surgery

    Directory of Open Access Journals (Sweden)

    Luca Leone

    2016-12-01

    Full Text Available Introduction: Testicular benign tumors are very rare (< 5%. Testicular Angiofibroma (AF is one of those, however the gold standard of treatment and follow-up is still unclear. Case report: A 47 years-old man with only one functioning testis was referred to our clinic for a palpable right testicular mass and atrophic contralateral testis. Patient underwent testis-sparing surgery with inguinal approach and intraoperative frozen sections examination with diagnosis of AF. Final histology confirmed AF. Post-operative follow-up was uneventful. Clinical and ultrasonographic follow-up was negative after 8 months. Conclusion: We report a conservative surgery in a patient with AF of the solitary testis. AF is a benign para-testicular fibrous neoplasm that could be misinterpreted as malignant tumor and treated with orchiectomy. Testis-sparing surgery is recommended in this case with intraoperative pathological examination. The excision of the mass is enough but in front of a possible recurrence a long follow-up is advisable.

  3. TGF-β superfamily signaling in testis formation and early male germline development.

    Science.gov (United States)

    Young, Julia C; Wakitani, Shoichi; Loveland, Kate L

    2015-09-01

    The TGF-β ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germline differentiation. BMPs are essential for the interactive instructions between multiple cell types in the early embryo that drive initial specification of gamete precursors. In the nascent foetal testis, several ligands including Nodal, TGF-βs, Activins and BMPs, serve as key masculinizing switches by regulating male germline pluripotency, somatic and germline proliferation, and testicular vascularization and architecture. In postnatal life, local production of these factors determine adult testis size by regulating Sertoli cell multiplication and differentiation, in addition to specifying germline differentiation and multiplication. Because TGF-β superfamily signaling is integral to testis formation, it affects processes that underlie testicular pathologies, including testicular cancer, and its potential to contribute to subfertility is beginning to be understood. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. DESARTICULACIÓN DE DISCURSOS NACIONALISTAS EN EL CINE DE AUTOR BOLIVIANO: 3B´S Y SOCAVÓNCINE

    Directory of Open Access Journals (Sweden)

    Mariana Lacunza Mendizábal

    2017-12-01

    Full Text Available Distinta a México, Argentina y Brasil, Bolivia tiene una industria cinematográfica poco desarrollada que no ha logrado consolidarse por varias razones. Entre éstas está la falta de apoyo estatal, el escaso desarrollo profesional en estas áreas y una carencia de cultura cinematográfica y visual en general. Sin embargo, durante la última década, la industria cinematográfica boliviana ha sido partícipe de logros importantes gracias a la aparición de las nuevas tecnologías. Películas digitales hechas por una nueva generación de jóvenes directores reconocidos globalmente se han desarrollado en tres ramas distintas: a cine de autor, b cine documental y c cortometrajes. Al mismo tiempo, la producción de este tipo de filmes se apoya en un esfuerzo colectivo, como es el caso de RAV (Rojo, Amarillo y Verde, 2006 de Rodrigo Bellot, Martín Bolulocq y Sergio Bastani y aquellos filmes producidos por el colectivo SocavónCine desde el año 2013. Este artículo busca explorar cómo el más reciente cine boliviano de autor desarticula discursos de identidad nacional al deconstruir oposiciones binarias. Además,  este artículo busca examinar la aplicabilidad del cine de autor y de las prácticas colaborativas en los “cines pequeños” o “small cinemas” al comparar y contrastar ambos grupos a través del análisis de las formas de producción y corrientes estéticas.

  5. Autores de homicídios passionais: narrativas do crime, histórias de vida e dos relacionamentos

    OpenAIRE

    Barbosa, Bibiana Calatayud

    2015-01-01

    A violência de gênero constitui uma problemática relevante em nossa sociedade. Nos casos mais graves, pode culminar em episódios de extrema violência, os homicídios passionais. Objetivos: Este estudo investigou a história de vida e dos relacionamentos amorosos de autores de homicídios passionais, identificando suas vivências e narrativas sobre os eventos desta trajetória, até o cometimento do crime. Método: Foi utilizado o procedimento de estudo de casos múltiplos. Participaram três homens co...

  6. Origins of the Salado, Seven Rivers, and San Andres salt margins in Texas and New Mexico: Revision 1: Topical report

    International Nuclear Information System (INIS)

    Boyd, S.D.; Murphy, P.J.

    1987-02-01

    The present boundaries of the San Andres, Seven Rivers, and Salado salts generally lie along the periphery of the Palo Duro and Tucumcari Basins. Various geologic mechanisms occurring singularly or in combination determined the positions of the salt margins. These mechanisms include nondeposition of salt and syndepositional and postdepositional dissolution. In New Mexico, San Andres units pinch out against the Pedernal and Sierra Grande Uplifts, indicating that nondeposition established the original salt margins there. Syndepositional dissolution of exposed Upper San Andres salts occurred in response to Guadalupian upwarp of the basin margins. Triassic erosion differentially removed Permian salt-bearing formations along the uplifts. Late Tertiary dissolution is indicated by fill of north-south trending collapse valleys. In Texas, Guadalupian upwarp along the Amarillo Uplift caused pinchout of Units 2 and 3 in the Lower San Andres and influenced the deposition of subsequent salt-bearing strata. The discontinuity of Upper San Andres evaporites across the Amarillo Uplift suggests syndepositional dissolution. Along the eastern and northeastern basin margin, dissolution may have accompanied Triassic erosion of locally uplifted Upper Permian strata. Tertiary dissolution is recognized beneath anomalously thick Ogallala Formation sections that overlie collasped Permian strata. 49 refs., 31 figs., 2 tabs

  7. Ecrire à la suite de : Andrée Lacelle, Andrée Christensen et Jacques Flamand, Paul Savoie et Dyane Léger

    Directory of Open Access Journals (Sweden)

    Catherine Parayre

    2012-05-01

    Full Text Available « Ecrire à la suite de » est un procédé d’écriture courant dans la littérature, qu’il s’agisse de mettre en relief l’intertextualité de l’œuvre (par exemple, en incluant des citations, de s’adonner à un travail basé sur l’intermédialité (par exemple, dans un texte rédigé à partir de photographies ou encore d’écrire à quatre mains, lorsqu’un des deux auteurs ajoute son texte à celui du partenaire d’écriture. Ne faisant pas exception, les littératures francophones du Canada pratiquent tout aussi fréquemment cette écriture de l’après. Le présent article en examinera quelques exemples dans des œuvres de nature introspective : La lumière et l’heure : poèmes et carnets (2004 d’Andrée Lacelle, avec des tableaux de Réjine Halimi ; Lithochronos ou le premier vol de la pierre (1999 d’Andrée Christensen et Jacques Flamand, avec des photographies de Christensen ; et L’incendiaire (2008 de Paul Savoie et Dyane Léger. L’analyse montrera que l’écriture « à la suite de », aussi variées qu’en soient les manifestations, non seulement met en évidence la présence de l’auteur dans ces textes, mais a aussi pour résultat, dans ces œuvres méditatives, de dédramatiser et d’amenuiser l’intensité de la réflexion existentielle.

  8. Study on changes of sperm count and testis tissue in black mouse after neutron irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Ki Jung; Seo, Won Sook [KAERI, Daejeon (Korea, Republic of); Son, Hwa Young [Chungnam National Univ., Daejeon (Korea, Republic of)

    2006-03-15

    For the purpose of the biological effect in black mouse by neutron irradiation, mice were irradiated with 16 or 32 Gy neutron (flux: 1.036739E+09) by lying flat pose at BNCT facility on HANARO Reactors. And 90 days later of irradiation, physical changes of testis and testis tissue were examined. There were no weight changes but a little bit volume changes and sperm counts in the tests. Atrophy of seminiferous tubules irradiated with 32 Gy neutron is increased in number and severity and those in stage VI showed depletion of spermatogonia and pachytene spermatocytes compared to the non-irradiated control group. Testis damage of black mouse was not recovered after long time by 32 Gy neutron irradiation.

  9. Study on changes of sperm count and testis tissue in black mouse after neutron irradiation

    International Nuclear Information System (INIS)

    Chun, Ki Jung; Seo, Won Sook; Son, Hwa Young

    2006-01-01

    For the purpose of the biological effect in black mouse by neutron irradiation, mice were irradiated with 16 or 32 Gy neutron (flux: 1.036739E+09) by lying flat pose at BNCT facility on HANARO Reactors. And 90 days later of irradiation, physical changes of testis and testis tissue were examined. There were no weight changes but a little bit volume changes and sperm counts in the tests. Atrophy of seminiferous tubules irradiated with 32 Gy neutron is increased in number and severity and those in stage VI showed depletion of spermatogonia and pachytene spermatocytes compared to the non-irradiated control group. Testis damage of black mouse was not recovered after long time by 32 Gy neutron irradiation

  10. Stage IE nonHodgkin's lymphoma of the testis: a need for a brief aggressive chemotherapy

    International Nuclear Information System (INIS)

    Roche, H.; Suc, E.; Pons, A.; Woodman, F.; Huguet-Rigal, F.; Caveriviere, P.; Carton, M.

    1989-01-01

    Primary nonHodgkin's lymphoma of the testis is a localized disease in 50 per cent of the cases. Clinical records and pathological material from 9 stage IE cancer patients treated at our institutions were reviewed. All but 1 patient had B cell type lymphomas of intermediate (6) or high (3) grade according to the Working Formulation. Mean survival was 49 months and actuarial survival was 74 per cent at 5 years. Chemotherapy differed with time and frequently was associated with subdiaphragmatic involved field and prophylactic contralateral testis radiotherapy. In view of the good prognosis of patients receiving doxorubicin-based chemotherapy and recent reports on low stage nonHodgkin's lymphoma we recommend an aggressive brief therapy for stage IE lymphoma of the testis after orchiectomy

  11. The structural and functional state of hemomicrocirculatory bed and parenchyma of the testis in varicocele

    Directory of Open Access Journals (Sweden)

    O. E. Khallo

    2015-08-01

    Full Text Available Varicose veins of the spermatic cord and testis membranes play a key role in the development of male infertility. Aim. To study the structural features of the bloodstream and testicular parenchyma in terms of varicose veins of the spermatic cord and testis membranes. Meyhods and results. In 23 testicular preparations taken from men of mature age convoluted seminiferous tubules diameter, number of cells of spermatogenic epithelium and interstitial endocrinocytes nuclei volume were studied using macro- and microscopic morphometric methods. It was established that in varicocele testis volume, diameter of convoluted seminiferous tubules and interstitial endocrinocytes nuclei volume significantly reduced. Conclusion. This indicates the presence of circulatory hypoxia of testicles, which leads to a decrease in the volume of interstitial endocrinocytes nuclei by 31%, thereby reducing their functional properties.

  12. Cell-selective determination of trace elements in testis by SR-XRF analysis with nanoprobe

    International Nuclear Information System (INIS)

    Homma-Takeda, Shino; Nishimura, Yoshikazu; Watanabe, Yoshito; Yukawa, Masae; Ueno, Shunji; Terada, Yasuko

    2005-01-01

    Organotin compounds are widely used in industry and its environmental contamination by these compounds has recently become a concern. It is known that they act as endocrine disruptors but details of the dynamics of Sn in reproductive organs are still unknown. In the present study, we attempted to determine Sn in the testis of rats exposed to tributyltin chloride (TBTC) cell-selectively by synchrotron radiation X-ray florescence analysis with nanoprobe. TBTC was orally administered to rats at a dose of 45 μmol/kg per day for 3 days. One day later, Sn was detected in spermatozoa at the stage VIII seminiferous tubule, which are the final step of spermatogenesis in the testis. Sn levels in the microdissectioned seminiferous tubules determined by inductively coupled argon plasma-mass spectrometry were approximately equivalent to that in the testis. These data indicate that Sn accumulates in germ cells as well as in spermatozoa in a short period of TBTC exposure. (author)

  13. Genome-scale analysis of positional clustering of mouse testis-specific genes

    Directory of Open Access Journals (Sweden)

    Lee Bernett TK

    2005-01-01

    Full Text Available Abstract Background Genes are not randomly distributed on a chromosome as they were thought even after removal of tandem repeats. The positional clustering of co-expressed genes is known in prokaryotes and recently reported in several eukaryotic organisms such as Caenorhabditis elegans, Drosophila melanogaster, and Homo sapiens. In order to further investigate the mode of tissue-specific gene clustering in higher eukaryotes, we have performed a genome-scale analysis of positional clustering of the mouse testis-specific genes. Results Our computational analysis shows that a large proportion of testis-specific genes are clustered in groups of 2 to 5 genes in the mouse genome. The number of clusters is much higher than expected by chance even after removal of tandem repeats. Conclusion Our result suggests that testis-specific genes tend to cluster on the mouse chromosomes. This provides another piece of evidence for the hypothesis that clusters of tissue-specific genes do exist.

  14. Identification of Hedgehog signaling outcomes in mouse testis development using a hanging drop-culture system.

    Science.gov (United States)

    Szczepny, Anette; Hogarth, Cathryn A; Young, Julia; Loveland, Kate L

    2009-02-01

    The Hedgehog (Hh) signaling pathway affects fetal testis growth. Recently, we described the dynamic cellular production of Hh signaling pathway components in juvenile and adult rodent testes. The Hh signaling is understood to regulate cord formation in the fetal testis, but minimal knowledge exists regarding how Hh signaling impacts the postnatal testis. To investigate this, we employed hanging drop cultures, which are used routinely in embryoid body formation. This approach has the advantage of using small media volume, and we examined its suitability for short-term culture of both murine embryonic gonads and adult testis tubules. The effects of cyclopamine, a specific Hh signaling inhibitor, were examined following culture of Embryonic Day 11.5 urogenital ridges (as control) and adult seminiferous tubule fragments for 24-48 h using histological, cell proliferation, and gene expression analyses. Cultured embryonic testes displayed generally normal cord structure, anti-Müllerian hormone (Amh) expression, and cell proliferation; known Hh target gene expression (Gli1, osteopontin, official symbol Spp1, and Amh) was altered in response to cyclopamine. Cultured adult tubules exhibited some loss of seminiferous epithelium organization over 48 h. Spermatogonia continued to proliferate, however, and no significant loss of viability was noted overall. Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells. These novel results identify Hh target genes in the testis and demonstrate this signaling pathway likely affects cell survival and differentiation in the context of normal adult testis.

  15. Follitropin receptors in rat testis. Characterization with enzymatically 125I-labeled human follitropin.

    Science.gov (United States)

    Ketelslegers, J M; Catt, K J

    1978-07-03

    The interaction between enzymatically radioiodinated human follitropin and the follitropin receptors in testis homogenate was investigated in immature and adult rats. The 125I-labeled human follitropin exhibited high binding activity with specific binding of up to 17% in the presence of an excess of testis homogenate. Approx. 50% of the bound hormone could be eluted at pH 5, and the receptor purified tracer exhibited a 3.6-fold increase in binding activity when compared with the original tracer preparation. Quantitative analysis of equilibrium binding data was performed with corrections for the measured specific activity and maximum binding activity of the tracer hormone. The equilibrium association constants (Ka) determined 24 degrees C were not significantly different in immature and adult rat testis, and the mean value for Ka was 3.9 . 10(9) M-1. At 37 degrees C, the Ka value obtained using immature rat testis was 1.3 . 10(10) M-1. The association of 125I-labeled human follitropin with immature rat testis homogenate was time and temperature dependent. In the presence of an excess of unlabeled hormone, 30--60% of the preformed hormone . receptor complex was dissociated after 24 h incubation. A specific and sensitive radioligand-receptor assay for follitropin was developed using immature rat testis homogenate. The minimum detectable dose of purified human follitropin was 0.6 ng, and human urinary and pituitary follitropin, ovine follitropin and pregnant mare serum gonadotropin reacted in the assay with equivalent slopes. The potencies of highly purified pregnent mare serum gonadotropin and highly purified human follitropin were similar in the radioligand-receptor assay, consistent with the follitropin bioactivity of the equine gonadotropin.

  16. Long non-coding RNA expression profiling of mouse testis during postnatal development.

    Directory of Open Access Journals (Sweden)

    Jin Sun

    Full Text Available Mammalian testis development and spermatogenesis play critical roles in male fertility and continuation of a species. Previous research into the molecular mechanisms of testis development and spermatogenesis has largely focused on the role of protein-coding genes and small non-coding RNAs, such as microRNAs and piRNAs. Recently, it has become apparent that large numbers of long (>200 nt non-coding RNAs (lncRNAs are transcribed from mammalian genomes and that lncRNAs perform important regulatory functions in various developmental processes. However, the expression of lncRNAs and their biological functions in post-natal testis development remain unknown. In this study, we employed microarray technology to examine lncRNA expression profiles of neonatal (6-day-old and adult (8-week-old mouse testes. We found that 8,265 lncRNAs were expressed above background levels during post-natal testis development, of which 3,025 were differentially expressed. Candidate lncRNAs were identified for further characterization by an integrated examination of genomic context, gene ontology (GO enrichment of their associated protein-coding genes, promoter analysis for epigenetic modification, and evolutionary conservation of elements. Many lncRNAs overlapped or were adjacent to key transcription factors and other genes involved in spermatogenesis, such as Ovol1, Ovol2, Lhx1, Sox3, Sox9, Plzf, c-Kit, Wt1, Sycp2, Prm1 and Prm2. Most differentially expressed lncRNAs exhibited epigenetic modification marks similar to protein-coding genes and tend to be expressed in a tissue-specific manner. In addition, the majority of differentially expressed lncRNAs harbored evolutionary conserved elements. Taken together, our findings represent the first systematic investigation of lncRNA expression in the mammalian testis and provide a solid foundation for further research into the molecular mechanisms of lncRNAs function in mammalian testis development and spermatogenesis.

  17. ¿Quién puede ser autor de un artículo científico?

    Directory of Open Access Journals (Sweden)

    Marco González T

    2011-04-01

    Full Text Available De acuerdo con el diccionario de la Real Academia Española (1, autor tiene cinco acepciones, pero la que se acerca a los intereses del presente escrito reza así: “Persona que ha producido alguna obra científica, literaria o artística”. No obstante, en el ámbito científico y académico esta definición puede ser más amplia, compleja y aun alcanzar diferentes connotaciones si se tienen en cuenta algunas reflexiones generales sobre la materia y no menos importante cuando se tiene presente; como debería ser, las razones éticas para firmar como autor o coautor de un artículo. Estas consideraciones son las intrínsecas de la investigación y que se generan dentro de un grupo en particular, que se preocupa, por ejemplo, en ser el primero en publicar artículos sobre un tema específico. Otros, con otra óptica, podrían tener interés en ostentar el mayor número de artículos publicados en una determinada área del conocimiento.

  18. Adolescentes como autores de si próprios: cotidiano, educação e o hip hop

    Directory of Open Access Journals (Sweden)

    Viviane Melo de Mendonça Magro

    Full Text Available Este artigo pretende discorrer sobre o cotidiano de adolescentes urbanos, mais especificamente as culturas juvenis, com o objetivo de apreender outros significados de ser adolescente no contexto contemporâneo e suas implicações em processos educativos. Diante da diversidade de culturas juvenis existentes atualmente, ressaltamos o movimento hip hop. Os adolescentes participantes desse movimento são descritos como protagonistas de seu próprio processo educativo, no qual deixam de ser meros atores e agentes de um modelo social e se tornam "autores de si próprios"; ou seja, no hip hop eles resgatam a educação como uma formação de "autores-cidadãos". Portanto, a visibilidade de outros modos de ser adolescente, que estão presentes no contexto de educação não-formal e informal das culturas juvenis, pode contribuir para uma compreensão da adolescência urbana que reconhece o adolescente como um sujeito capaz de formular questões relevantes e ações significativas no campo social.

  19. The protective effect of ischemic preconditioning on rat testis

    Directory of Open Access Journals (Sweden)

    Ciralik Harun

    2007-12-01

    Full Text Available Abstract Background It has been demonstrated that brief episodes of sublethal ischemia-reperfusion, so-called ischemic preconditioning, provide powerful tissue protection in different tissues such as heart, brain, skeletal muscle, lung, liver, intestine, kidney, retina, and endothelial cells. Although a recent study has claimed that there are no protective effects of ischemic preconditioning in rat testis, the protective effects of ischemic preconditioning on testicular tissue have not been investigated adequately. The present study was thus planned to investigate whether ischemic preconditioning has a protective effect on testicular tissue. Methods Rats were divided into seven groups that each contained seven rats. In group 1 (control group, only unilateral testicular ischemia was performed by creating a testicular torsion by a 720 degree clockwise rotation for 180 min. In group 2, group 3, group 4, group 5, group 6, and group 7, unilateral testicular ischemia was performed for 180 min following different periods of ischemic preconditioning. The ischemic preconditioning periods were as follows: 10 minutes of ischemia with 10 minutes of reperfusion in group 2; 20 minutes of ischemia with 10 minutes of reperfusion in group 3; 30 minutes of ischemia with 10 minutes of reperfusion in group 4; multiple preconditioning periods were used (3 × 10 min early phase transient ischemia with 10 min reperfusion in all episodes in group 5; multiple preconditioning periods were used (5, 10, and 15 min early phase transient ischemia with 10 min reperfusion in all episodes in group 6; and, multiple preconditioning periods were used (10, 20, and 30 min early phase transient ischemia with 10 min reperfusion in all episodes in group 7. After the ischemic protocols were carried out, animals were sacrificed by cervical dislocation and testicular tissue samples were taken for biochemical measurements (protein, malondialdehyde, nitric oxide and histological examination

  20. IMPARARE L’ITALIANO L2/LS CON TESTI TEATRALI

    Directory of Open Access Journals (Sweden)

    Erminia Ardissino

    2010-09-01

    Full Text Available Il saggio tratta dell'impiego di testi teatrali come fonti di esercizi per l'apprendimento dell'italiano L2/LS. Dopo alcune riflessioni teoriche, si presentano sei proposte di lavoro, con relative soluzioni, adatte a studenti del livello B2-C2 del quadro di riferimento. Si tratta di esercizi ricavati da drammi in un unico atto di Pirandello (La morsa e Lumìe di Sicilia, da Verga (un confronto fra Cavalleria rusticana nella forma drammatica e novellistica, e da Tommaso Landolfi (Ombre. Ogni proposta sfrutta una peculiarità del testo teatrale che si costituisce nell'incontro di dialoghi con didascalie. Anzitutto si tratta di comprendere come si costruiscono i personaggi, quindi di vedere la funzione delle didascalie in relazione al testo, infine di riflettere sulle diverse modalità in cui avvengono i dialoghi, includendo le forme di silenzio. Il testo teatrale appare così molto adatto ad esercizi di lingua, perché mette in gioco le capacità interpretative e immaginative degli studenti, li fa discutere e parlare sulla base delle loro intuizioni.   This paper investigates the use of play scripts as inspiration for Italian L2/FL exercises. After a brief discussion on theory, six project proposals and their solutions, suitable for B2-C2 level students, are presented.  These exercises are based on one-act plays by Pirandello (La Morsa and Lumìe di Sicilia, Verga (a comparison between Cavalleria Rusticana in drama and narrative forms and Tommaso Landolfi (Ombre.  Each project focuses on a specific aspect of the script  and is made up of dialogues with captions. After the way the characters are constructed is investigated, then the function of the captions in relation to the texts is considered, and finally students reflect on the different ways the dialogues are presented, including the pauses. Play scripts lend themselves to language exercises, because they encourage students to use their interpretation skills and imaginations to talk about

  1. Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager

    DEFF Research Database (Denmark)

    Sørensen, Lasse

    2012-01-01

    Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager......Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager...

  2. Teresa Andrés y la organización Cultura Popular: una propuesta de coordinación bibliotecaria (1936-1938

    Directory of Open Access Journals (Sweden)

    Seguí i Francés, Romà

    2011-12-01

    Full Text Available Teresa Andrés Zamora es conocida por su actividad al frente de la Sección de Bibliotecas de Cultura Popular. Este trabajo describe las relaciones que se establecieron entre Teresa Andrés y Cultura Popular, tras hacerse cargo de las responsabilidades del Ministerio de Instrucción Pública.

  3. Book Review: America’s Blind Spot: Chávez, Oil and US Security by Andrés Cala and Michael Economides

    DEFF Research Database (Denmark)

    Boscan, Luis

    2014-01-01

    Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012.......Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012....

  4. Chloroma of the testis in a patient with a history of acute myeloid leukemia

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Sanei

    2017-01-01

    Full Text Available Chloroma, or granulocytic sarcoma, is a rare extramedullary solid hematologic cancer, found concomitant with acute myeloid leukemia. It is infrequently associated with other myeloproliferative disorders or chronic myelogenous leukemia. Chloroma of the testis after allogeneic bone marrow transplantation is particularly sparsely represented in the literature. It is suggested that an appropriate panel of marker studies be performed along with clinical correlation and circumspection to avoid misleading conclusions. We report an interesting case of a 32-year-old male with a clinical history of acute myelogenous leukemia, postallogeneic peripheral blood stem cell transplantation that was found to have chloroma of the right testis.

  5. Chloroma of the testis in a patient with a history of acute myeloid leukemia.

    Science.gov (United States)

    Sanei, Mohammad Hossein; Shariati, Matin

    2017-01-01

    Chloroma, or granulocytic sarcoma, is a rare extramedullary solid hematologic cancer, found concomitant with acute myeloid leukemia. It is infrequently associated with other myeloproliferative disorders or chronic myelogenous leukemia. Chloroma of the testis after allogeneic bone marrow transplantation is particularly sparsely represented in the literature. It is suggested that an appropriate panel of marker studies be performed along with clinical correlation and circumspection to avoid misleading conclusions. We report an interesting case of a 32-year-old male with a clinical history of acute myelogenous leukemia, postallogeneic peripheral blood stem cell transplantation that was found to have chloroma of the right testis.

  6. Synchronous rhabdomyosarcoma of the testis and kidney: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Babatunde M. Duduyemi

    2016-06-01

    Full Text Available Rhabdomyosarcoma is the commonest soft tissue sarcoma in both children and adolescents representing 40% of such tumours in North America and more than 50% in Africa. The involvement of the paratesticular tissue, testis and the kidney are generally rare and more so when it is occurring synchronously. We present a case of 22 year old male with inguinoscrotal swelling, fever and abdominal distention who was diagnosed as having obstructed left inguinoscrotal hernia and a right renal mass. The patient had surgery, and a diagnosis of synchronous rhabdomyosarcoma of the left testis, paratesticular tissue and right kidney was made by histology and immunohistochemistry.

  7. Recent adverse trends in semen quality and testis cancer incidence among Finnish men

    DEFF Research Database (Denmark)

    Jorgensen, N.; Vierula, M.; Jacobsen, R.

    2011-01-01

    Impaired semen quality and testicular cancer may be linked through a testicular dysgenesis syndrome of foetal origin. The incidence of testis cancer has been shown to increase among Finnish men, whereas there is no recent publication describing temporal trends in semen quality. Therefore, we...... carried out a prospective semen quality study and a registry study of testis cancer incidence among Finnish men to explore recent trends. A total of 858 men were investigated in the semen quality study during 1998-2006. Median sperm concentrations were 67 (95% CI 57-80) million/mL, 60 (51-71) and 48 (39...

  8. Endocrine function in patients treated for carcinoma in situ in the testis with irradiation

    DEFF Research Database (Denmark)

    Petersen, Peter Meidahl; Daugaard, Gedske; Rørth, Mikael

    2003-01-01

    CIS is found in the contralateral testis in 5% of the patients with testicular germ cell cancer. The management of CIS in the contralateral testis is important because the majority - if not all - cases of CIS will progress to invasive disease without treatment. It is well documented that testicular...... are sparse. One study has indicated that more radiotherapy with lower doses per fraction could be useful, but more data are needed to confirm this. Endocrine testicular function has been shown to be impaired already before treatment in patients with CIS and is further impaired after testicular irradiation...

  9. Purification of beta-acetylglucosaminase and beta-galactosidase from ram testis.

    Science.gov (United States)

    Caygill, J C; Roston, C P; Jevons, F R

    1966-02-01

    1. The presence of beta-galactosidase (EC 3.2.1.23) in an acetic acid extract of ram testis is reported. Some properties of the crude enzyme preparation were studied. 2. The purification of beta-acetylglucosaminase (EC 3.2.1.30) and of beta-galactosidase from the ram-testis extract by ammonium sulphate precipitation and chromatography on a CM-cellulose column is described. 3. The final purifications of the separated enzymes achieved were for the beta-acetylglucosaminase 35 times and for the beta-galactosidase 99 times. 4. The possibility of using DEAE-cellulose and Sephadex G-200 to purify the enzymes was investigated.

  10. Intratubular Germ Cell Neoplasia of the Testis, Bilateral Testicular Cancer, and Aberrant Histologies.

    Science.gov (United States)

    Sharma, Pranav; Dhillon, Jasreman; Sexton, Wade J

    2015-08-01

    Intratubular germ cell neoplasia (ITGCN) is a precursor lesion for testicular germ cell tumors, most of which are early stage. ITGCN is also associated with testicular cancer or ITGCN in the contralateral testis, leading to a risk of bilateral testicular malignancy. Testicular biopsy detects most cases, and orchiectomy is the treatment of choice in patients with unilateral ITGCN. Low-dose radiation therapy is recommended in patients with bilateral ITGCN or ITGCN in the solitary testis, but the long-term risks of infertility and hypogonadism need to be discussed with the patient. Rare histologies of primary testicular cancer are also discussed. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Fromleik i Black Supper, Piss Christ og Crucifixion, tre fotografi av Andres Serrano

    OpenAIRE

    Vinje, Lilly

    2006-01-01

    Oppgåva skal omhandla tre utvalgte foto av fotografen Andres Serrano, ein amerikanar født i 1950. Enkeltbileta det er snakk om er Black Supper (1990), Piss Christ og Crucifixion (begge 1987). Dei er laga ved at kitschfigurar er nedsenka i gjennomsiktige behaldarar fyllte av kroppsvæsker og vatn; vatn i Black Supper, urin i Piss Christ og blod i Crucifixion. Henholdsvis framstiller dei Nattverden, Jesus på krossen og Krossfestinga (tre figurar). Serrano befinn seg med desse innanfor religiøs k...

  12. Despedida al maestro Arturo Andrés Roig (1922 – 2012

    Directory of Open Access Journals (Sweden)

    Enrique Dussel

    2015-07-01

    Full Text Available En ocasión del fallecimiento de Arturo Andrés Roig (Doctor Honoris Causa por las Universidades Nacional de Río Cuarto, Argentina; Nacional de San Luis, Argentina; Autónoma de Managua, Nicaragua. Profesor Honorario en las Universidades Nacional del Comahue -Argentina-, y Andina Simón Bolívar -Ecuador- queremos sumarnos a la larga serie de homenajes que ha recibido. Para ello, reproducimos aquí tres memoriales dedicados al maestro por filósofos americanos.

  13. Andres Bello and the Dissemination of Astronomy: Education and Scientific Rhetoric

    Directory of Open Access Journals (Sweden)

    Verónica Ramírez Errázuriz

    2017-12-01

    Full Text Available This paper analyzes the astronomical texts written by Andres Bello between 1810 and 1848, from its educational nature to its rhetorical expression, suggesting that their main purpose was to show the advances in the field - in terms of knowledge production and also technology development- in order to improve the material and intellectual environment of the nation. It also stands that astronomy should be tought by activating creativity and imagination, which may be linked with Bello’s willing to avoid science and art develop apart from each other, keeping, in this case astronomy bonded with literature.

  14. Andre Hellegers and Carroll House: architect and blueprint for the Kennedy Institute of Ethics.

    Science.gov (United States)

    Harvey, John Collins

    2004-06-01

    The Newman programs established at secular colleges and universities provided an opportunity for intellectual, spiritual, and social growth among the Catholic student population. As a young physician and junior medical faculty member, Andre Hellegers took part in the early organization and ongoing work of Carroll House, the Newman Center at the Johns Hopkins Medical Institutions. Helleger's experience at Carroll House enabled him to develop a clear blueprint of an academic center of excellence for the scientific, theological, and philosophical exploration of the many problems that he had seen and foresaw in medicine. That center would become Georgetown's Kennedy Institute of Ethics.

  15. Jovens de Santo André, SP, Brasil: Um estudo sobre valores em diferentes grupos sociais

    OpenAIRE

    Sheila Aparecida Ferreira Lachtim

    2010-01-01

    Esta dissertação se propõe a: apreender valores sociais contemporâneos, notadamente aqueles referidos ao consumo de drogas, discutir diferenças entre esses valores nos diferentes grupos sociais; e analisar possíveis relações entre esses valores. Trata-se de um estudo qualitativo de caráter exploratório, descritivo e analítico que utilizou um roteiro de entrevista semi-estruturada para apreensão do objeto. Um total de 86 jovens participou, de diferentes regiões do município de Santo André, SP,...

  16. Lean versus Quick Response Manufacturing og andre koncepter - er Lean den eneste ene?

    DEFF Research Database (Denmark)

    Michelsen, Aage U

    2005-01-01

    Begrebet Lean har gennem de senere år vundet en enorm udbredelse. Antallet af publikationer om Lean har været eksplosivt stigende, og mange virksomheder har gennemført eller gennemfører Lean-projekter. Er Lean et nyt koncept? Er Lean den eneste løsning? Kan Lean kombineres med tankegange og princ...... løsning af en anden produktionsopgave. I fjerde afsnit skitseres kort relationerne mellem Lean og to andre begreber, Six Sigma og TPM, der begge har samme mål som Lean, men forskellige udgangspunkter og forskellige indfaldsvinkler....

  17. Etnic discrimination and income in San Andrés Island, Colombia

    Directory of Open Access Journals (Sweden)

    Javier Yabrudy

    2011-12-01

    Full Text Available This document examines, bases on the analysis of observable characteristics, if an income gapexists between the raizal population and non raizal population of San Andres Island. For thispurpose, the information of the SISBEN II survey for the year 2004, compelled by the NationalPlanning Department (DNP, Spanish acronym is used. The methodological strategy uses quantileregressions to determine the existence of pay gaps throughout the distribution of income. Theresults suggest that being raizal has a negative impact on income for the lower quantiles. However,this difference vanishes as income increases, becoming positive at higher levels.

  18. APA/APAGS Award for Distinguished Graduate Student in Professional Psychology: Octavio Andres Santos.

    Science.gov (United States)

    2017-12-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded annually by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. The 2017 award winner is Octavio Andres Santos, who has demonstrated through several initiatives "effective engagement with advocacy, professional organizations, and research in the area of health disparities and multicultural/multilingual assessment." Santos's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  19. Study on the abnormalities in sperm and gene mutation induced by retention of 147Pm in testis

    International Nuclear Information System (INIS)

    Zhu Shoupeng; Lun Mingyue; Yang Shuqin

    1990-05-01

    The purpose of the present study is to ascertain 147 Pm retention in testis and its radiogenotoxicological effects of gene mutation through varying radioactivities of internal exposure. Especially the accumulation of 147 Pm in testis induces the dominant lethal, dominant skeletal mutation and abnormalities in sperm. Studies indicated that the cumulative absorption dose in testis increases as the internal exposure of 147 Pm increases. The internal exposure of 147 Pm can destroy the genetic materials and raise the rates of dominant lethal and dominant mutation of skeletal abnormalities in the offspring. The relationship between the rate of dominant skeletal mutation (B) and accumulated radioactivities of 147 Pm (D) in testis can be described by a linear equation that is B 20.68 + 35.48 D. The relationship between abnormalities of the sperm and the cumulative dose from 147 Pm in testis can be expressed by the following equation: S = 10.8705 D 0.5224 + 3.1768

  20. André Leroi-Gourhan (25 août 1911–19 février 1986)

    OpenAIRE

    Soulier, Philippe

    2007-01-01

    André Leroi-Gourhan (25th August 1911 – 19th February 1986) A short biography of André Leroi-Gourhan is here presented, beginning in 1927, at the moment of his student years, until his retirement in 1982. It rests on a systematic analysis of his publications and on his personal and professional archives, collected and studied for the first time in 2001 when the author was temporally engaged by the CNRS. Going beyond the pure biography of events, such as those already presented in numerous po...

  1. Origen de la surgencia del Balneario de San Andrés (Provincia de Jaén)

    OpenAIRE

    Hidalgo Estévez, Mari Carmen; Rey Arrans, Javier; Redondo, L.

    1997-01-01

    The hydrogeological context of the San Andrés spa (province of Jaén) is analysed in this work. Piezometric data, hydrochemical analysis and groundwater quality trends are discussed for groundwater samples obtained from the main aquifer units in the region (jurassic carbonatic aquifer and miocene detrital aquifer) in order to stablish the origin of the San Andrés spring. Considering altitude, discharge rate, temperature and hydrochemical features of the spring, it seems to be related to the mi...

  2. AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences

    International Nuclear Information System (INIS)

    Dura, Joseph A.; Pierce, Donald J.; Majkrzak, Charles F.; Maliszewskyj, Nicholas C.; McGillivray, Duncan J.; Loesche, Mathias; O'Donovan, Kevin V.; Mihailescu, Mihaela; Perez-Salas, Ursula; Worcester, David L.; White, Stephen H.

    2006-01-01

    An elastic neutron scattering instrument, the advanced neutron diffractometer/reflectometer (AND/R), has recently been commissioned at the National Institute of Standards and Technology Center for Neutron Research. The AND/R is the centerpiece of the Cold Neutrons for Biology and Technology partnership, which is dedicated to the structural characterization of thin films and multilayers of biological interest. The instrument is capable of measuring both specular and nonspecular reflectivity, as well as crystalline or semicrystalline diffraction at wave-vector transfers up to approximately 2.20 A -1 . A detailed description of this flexible instrument and its performance characteristics in various operating modes are given

  3. Statistical zonation technique and its application to the San Andres reservoir in the Poza Rica area, Vera Cruz, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Campa, M F; Romero, M R

    1969-01-01

    A statistical zonation technique developed by J.D. Testerman is presented referring to its application to the San Andres reservoir in the Poza Rica area in Veracruz, Mex. The method is based on a statistical technique which permits grouping of similar values of certain parameter, i.e., porosity, for individual wells within a field. The resulting groups or zones are used in a correlation analysis to deduce whether there is continuity of porosity in any direction. In the San Andres reservoir, there is a continuity of the porous media on NE-SW direction. This is an important fact for the waterflooding project being carried on.

  4. Postsotsialismist vaatemängulinna = From Post-Socialism to the City of the Spectacle / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2007-01-01

    Büroo Alver Trummal Arhitektid töödest, Andres Alverist ja Tiit Trummalist. Ärihoonest Tallinnas Rävala pst. 4. Autorid: Andres Alver, Tiit Trummal, Tarmo Laht, Indrek Rünkla, Ulla Mets, Sven Koppel. Konstruktor Eido Uustalu (Eesti Projekt). Projekt 2001, valmis 2006. City Plazast Tallinnas Tartu mnt. 2. Autorid: A. Alver, T. Trummal, T. Laht, I. Rünkla, Martin Melioranski, U. Mets. Konstruktor: Tiit Masso, Pike Projekt. Sisekujundus (fuajeed, restoran): Pille Lausmäe. Projekt 2001, valmis 2004. Lõige, põhiplaan, 3 värv. välis- ja 5 sisevaadet

  5. Sex-biased miRNAs in gonad and their potential roles for testis development in yellow catfish.

    Science.gov (United States)

    Jing, Jing; Wu, Junjie; Liu, Wei; Xiong, Shuting; Ma, Wenge; Zhang, Jin; Wang, Weimin; Gui, Jian-Fang; Mei, Jie

    2014-01-01

    Recently, YY super-male yellow catfish had been created by hormonal-induced sex reversal and sex-linked markers, which provides a promising research model for fish sex differentiation and gonad development, especially for testis development. MicroRNAs (miRNAs) have been revealed to play crucial roles in the gene regulation and gonad development in vertebrates. In this study, three small RNA libraries constructed from gonad tissues of XX female, XY male and YY super-male yellow catfish were sequenced. The sequencing data generated a total of 384 conserved miRNAs and 113 potential novel miRNAs, among which 23, 30 and 14 miRNAs were specifically detected in XX ovary, XY testis, and YY testis, respectively. We observed relative lower expression of several miR-200 family members, including miR-141 and miR-429 in YY testis compared with XY testis. Histological analysis indicated a higher degree of testis maturity in YY super-males compared with XY males, as shown by larger spermatogenic cyst, more spermatids and fewer spermatocytes in the spermatogenic cyst. Moreover, five miR-200 family members were significantly up-regulated in testis when treated by 17α-ethinylestradiol (EE2), high dose of which will impair testis development and cell proliferation. The down-regulation of miR-141 and 429 coincides with the progression of testis development in both yellow catfish and human. At last, the expression pattern of nine arbitrarily selected miRNAs detected by quantitative RT-PCR was consistent with the Solexa sequencing results. Our study provides a comprehensive miRNA transcriptome analysis for gonad of yellow catfish with different sex genotypes, and identifies a number of sex-biased miRNAs, some of that are potentially involved in testis development and spermatogenesis.

  6. 'Sidun' e 'Creuza de mâ' di Fabrizio De André (1940–1999. La svolta etnica del cantautore genovese attraverso l’analisi di due canzoni esemplari

    Directory of Open Access Journals (Sweden)

    Vanna Lovato

    2014-01-01

    Full Text Available L’album Creuza de mâ (1984 di Fabrizio De André, composto e registrato grazie alla fondamentale collaborazione del musicista Mauro Pagani, rappresenta un unicum nella storia della canzone italiana, ed è più in generale un buon esempio di canzone d’autore moderna rielaborata secondo parametri musicali e linguistici diversi dagli standard della canzone di consumo tipici dell’epoca in cui l’album venne pubblicato, anticipando di quasi un decennio in Italia la moda della cosiddetta world music. Pur confermandosi ad oggi uno dei migliori esempi di ‘contaminazione’ tra canzone popolare –– rappresentata qui dall’uso del dialetto genovese –– e tradizione musicale mediterranea , nel 1984 il disco fu accolto in modo tiepido dal pubblico , ma ottenne  subito il plauso della critica e di molti colleghi ed estimatori, italiani e non; ricordiamo, tra gli altri, gli apprezzamenti fatti nel corso degli anni dal musicista inglese David Byrne.

  7. Euro Feast for Estonia - Feast in Time of Plague? / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2010-01-01

    Autor leiab, et Eesti Pank ja valitsus peaksid selgitama rahvale euroga liitumise vajadust ajal, mil terve maailm kannatab majanduskriisi all ja euroala riigid ei suuda täita Maastrichti kriteeriume ning euro jaoks on saabunud rasked ajad. Kreeka majandusnäitajatest

  8. August välja küll, aga kunas ja kuidas? / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2009-01-01

    USA majandustsüklite uurija Victor Zarnowitz väidab, et järsule majanduslangusele järgneb kiire tõus. Autor leiab, et Eestit võimaldavad majanduskriisist välja tuua mitte ainult õiged otsused valitsussektoris, vaid ka erasektoris

  9. Nargen Opera lummas Kõrvitsa muusikaga / Ruth Alaküla, Andres Laasik

    Index Scriptorium Estoniae

    Alaküla, Ruth, 1957-

    2006-01-01

    Von Krahli Teatris Peeter Jalaka lavastuses esietendunud Tõnu Kõrvitsa uued kammerooperid "Tuleaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libretode autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  10. Smeds lükkas liikvele EL-i bürokraadid / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2009-01-01

    19. veebr. Brüsselis Flaami Kuninglikus Teatris esietendunud lavastusest "Mental Finland", autor-lavastaja Kristian Smeds Soomest, kaasa teevad eesti näitlejad Juhan Ulfsak ja Eva Klemets. Tsiteeritakse ka teatri dramaturgi Ivo Kuyli, kes vahendab ajakirjanduses ilmunud kriitikat ja räägib oma muljetest

  11. La astronomía de un humanista, Juan Andrés

    Directory of Open Access Journals (Sweden)

    José Antonio SANDUVETE CHAVES

    2009-11-01

    Full Text Available RESUMEN: La páginas que siguen pretenden ofrecer una visión de conjunto del análisis que de la historia de la Astronomía realiza Juan Andrés, desde los orígenes de la humanidad hasta el siglo XVIII. Este análisis, incluido en su monumental obra Origen, progresos y estado actual de toda la literatura, destaca por su modernidad y precisión, constituyendo, por tanto, una interesante base de comparación entre la visión de la ciencia astronómica del humanismo ilustrado y la que pervive en la actualidad.ABSTRACT: The following pages attempt to offer a full view of the research into the history of astronomy made by Juan Andrés, from the beginning of human culture until the 18th century. This analysis, included in a broader work called Origen, progresos y estado de toda la literatura, stands out on account of its modern and precise ideas, thus representing an interesting knowledge base for comparing the view of astronomy during the Enlightenment with that of the present.

  12. A influência dos autores canônicos na autorização do psicanalista

    Directory of Open Access Journals (Sweden)

    Wilson de Albuquerque Cavalcanti Franco

    2013-12-01

    Full Text Available O artigo aborda a forma como se constroem as "autorias" no discurso psicanalítico - considerando, basicamente, as figuras de autor que organizam a composição de um discurso psicanalítico (Klein, Winnicott, Lacan, por exemplo. A partir de uma apresentação do estatuto da autoria na configuração do discurso psicanalítico, o texto questiona a centralidade da repetição de fórmulas com pretensão canônica e a figura geral do dogmatismo na "autorização" do psicanalista. Sugerem-se desdobramentos e reconfigurações dos fenômenos do dogmatismo e da autoridade no discurso psicanalítico.

  13. O autor no design de jóias: uma aproximação com o direito

    OpenAIRE

    Moraes, Viviane Nogueira de

    2012-01-01

    Este trabalho busca a compreensão acerca da sistemática da proteção ao autor no design de joioas, com tentativas de uma aproximação entre o Design eo direito a parti do conceito de autoria. por meio de análises binliográficas, iconográficas e de entrevista, busca-se entender como criações. O trabalho desevolve-se em três partes. A primeira parte trata de noções básicas sicas de Direito, própria joia. Já a segunda aborda i Design e sua concentuação adivinda Revolução Industrial, discutindo-se ...

  14. El plagio, una práctica cotidiana que atenta contra un derecho fundamental: El derecho de autor

    Directory of Open Access Journals (Sweden)

    Olga Beatriz Orozco Orozco

    2011-01-01

    Full Text Available El artículo pretende generar un espacio de reflexión sobre la problemática del plagio desde el punto de vista legal y sus implicaciones en el campo educativo, en especial el ciberplagio, convertido en una verdadera “plaga”, por las facilidades que ofrece la red internet. Por lo tanto, el plagio debe ser detectado y controlado para evitar la violación de un derecho fundamental: el derecho de autor. Desde un análisis de sus causas y consecuencias, se plantean estrategias para prevenir el plagio y de esta manera contribuir al fortalecimiento de la cultura de la legalidad y al fomento de la ética intelectual.

  15. Adaptive threshold control for auto-rate fallback algorithm in IEEE 802.11 multi-rate WLANs

    Science.gov (United States)

    Wu, Qilin; Lu, Yang; Zhu, Xiaolin; Ge, Fangzhen

    2012-03-01

    The IEEE 802.11 standard supports multiple rates for data transmission in the physical layer. Nowadays, to improve network performance, a rate adaptation scheme called auto-rate fallback (ARF) is widely adopted in practice. However, ARF scheme suffers performance degradation in multiple contending nodes environments. In this article, we propose a novel rate adaptation scheme called ARF with adaptive threshold control. In multiple contending nodes environment, the proposed scheme can effectively mitigate the frame collision effect on rate adaptation decision by adaptively adjusting rate-up and rate-down threshold according to the current collision level. Simulation results show that the proposed scheme can achieve significantly higher throughput than the other existing rate adaptation schemes. Furthermore, the simulation results also demonstrate that the proposed scheme can effectively respond to the varying channel condition.

  16. Comparative genomic and in situ hybridization of germ cell tumors of the infantile testis

    NARCIS (Netherlands)

    Mostert, M; Rosenberg, C; Stoop, H; Schuyer, M; Timmer, A; Oosterhuis, W; Looijenga, L

    Chromosomal information on germ cell tumors of the infantile testis, ie, teratomas and yolk sac tumors, is limited and controversial. We studied two teratomas and four yolk sac tumors using comparative genomic hybridization (CGH) and in situ hybridization. No chromosomal anomalies were found in the

  17. Why testes are resistant to hydatidosis: Is blood-testis-barrier ...

    African Journals Online (AJOL)

    Testes are extremely rare sites for echinococcosis. To our knowledge only three cases of testicular hydatid disease have been reported so far. In this laboratory animal model, we studied hydatidosis in rabbit testis. Fourteen male albino rabbits (body weight 2.5-3 kg) were randomized into two groups: Group A (study group), ...

  18. Why testes are resistant to hydatidosis: Is blood-testis-barrier ...

    African Journals Online (AJOL)

    There was demonstrable hydatid cyst (protoscoleces and germinative layer) in testes of five rabbits from Group A, but in one rabbit, both testes were normal. In Group B, three out of four rabbits developed peritoneal hydatidosis. The mechanism of testicular resistance to echinococcosis could be due to blood-testis barrier ...

  19. Hydatid cyst of testis: An unusual presentation of hydatid disease - case report and review of literature

    Directory of Open Access Journals (Sweden)

    Baldev Singh

    2001-01-01

    Full Text Available Hvdatid disease is a parasitic disease usually caused by Echinococcus granulosus. It usually presents with liver involvement and uncommonly lungs and rarely other organs are involved. A rare case of hydatid testis is reported that was provisionally diagnosed as testicular tumor.

  20. Comparison of ex vivo DSP and in vitro MBP Exposures on Fetal Testis Testosterone Production

    Science.gov (United States)

    In utero exposure to di‐butyl phthalate (DBP) during sex differentiation reduces androgen production and produces a characteristic profile of gene expression changes in the fetal testis. The DPB metabolite mono‐butyl phthalate (MBP) is hypothesized to produce these changes by ...

  1. Localization of S-100 proteins in the testis and epididymis of poultry and rabbits

    Science.gov (United States)

    Abd-Elmaksoud, Ahmed; Marei, Hany E. S.

    2014-01-01

    The present investigation was conducted to demonstrate S-100 protein in the testis and epididymis of adult chickens, Sudani ducks, pigeons, and rabbits. This study may represent the first indication for the presence of S-100 in the male reproductive organs of these species and might therefore serve as a milestone for further reports. In the testis of chickens, pigeons and rabbits, intense S-100 was seen in Sertoli cells. S-100 was also seen in the endothelial lining of blood vessels in rabbit testis. On the contrary, no S-100 reaction was detected in the Sertoli cells of Sudani ducks. In epididymis, the localization of S-100 had varied according to species studied; it was seen in the basal cells (BC) of epididymal duct in duck, non-ciliated cells of the distal efferent ductules in pigeons and ciliated cells of the efferent ductules and BC of rabbit epididymis. Conversely, S-100 specific staining was not detected in the epithelial lining of the rooster and pigeon epididymal duct as well as the principal cells of the rabbit epididymis. In conclusion, the distribution of the S-100 proteins in the testis and epididymis might point out to its roles in the male reproduction. PMID:25276477

  2. Two lectin-like receptors for alpha 1-acid glycoprotein in mouse testis

    DEFF Research Database (Denmark)

    Andersen, U O; Kirkeby, S; Bøg-Hansen, T C

    1997-01-01

    Three glycoforms of alpha 1-acid glycoprotein (AGP) were biotinylated to examine their binding in mouse testis by light microscopy. The transition from one stage to another in the spermatogenic cycle is marked with an appearance of a receptor for the Concanavalin A (Con A) non-reactive glycoform...

  3. GESTATIONAL EXPOSURE TO ETHANE DIMETHANESULFONATE (EDS) ALTERS DEVELOPMENT OF THE MOUSE TESTIS

    Science.gov (United States)

    GESTATIONAL EXPOSURE TO ETHANE DIMETHANESULFONATE (EDS) ALTERS DEVELOPMENT OF THE MOUSE TESTIS. D.K. Tarka*1,2, J.D. Suarez*2, N.L. Roberts*2, J.M. Rogers*1,2, M.P. Hardy3, and G.R. Klinefelter1,2. 1University of North Carolina, Curriculum in Toxicology, Chapel Hill, NC; 2USEPA,...

  4. Embryonic stem cell-like cells derived from adult human testis

    NARCIS (Netherlands)

    Mizrak, S. C.; Chikhovskaya, J. V.; Sadri-Ardekani, H.; van Daalen, S.; Korver, C. M.; Hovingh, S. E.; Roepers-Gajadien, H. L.; Raya, A.; Fluiter, K.; de Reijke, Th M.; de la Rosette, J. J. M. C. H.; Knegt, A. C.; Belmonte, J. C.; van der Veen, F.; de rooij, D. G.; Repping, S.; van Pelt, A. M. M.

    2010-01-01

    Given the significant drawbacks of using human embryonic stem (hES) cells for regenerative medicine, the search for alternative sources of multipotent cells is ongoing. Studies in mice have shown that multipotent ES-like cells can be derived from neonatal and adult testis. Here we report the

  5. An original procedure for balanus repair with transposition of the testis

    Directory of Open Access Journals (Sweden)

    D. G. Kurbatov

    2016-01-01

    Full Text Available The paper presents the unique clinical experience of successful sexual rehabilitation of a patient who has undergone penile amputation for cancer. Complex reconstruction of all parts of the lost organ, by using known methods and those proposed for the first time in global practice (balanus repair with transposition of the testis, was performed in the patient.

  6. Convenio "Andres Bello:" Informe Final [de la] Segunda Reunion de Ministros de Educacion de la Region Andina ("Andres Bello" Agreement: Final Report of the Second Meeting of the Andean Region Ministers of Education).

    Science.gov (United States)

    Ministros de Educacion de la Region Andina, Lima (Peru).

    This final report of the second meeting of the Andean Region Ministers of Education subscribing to the Andres Bello Agreement on education and culture contains a resume of the individual sessions and the proposals approved during that meeting. The proposals cover various educational problems and issues and begin with the Declaration of Lima which…

  7. Influence of Aluminium Chloride on Antioxidant System in the Testis and Epididymis of Rats

    Directory of Open Access Journals (Sweden)

    Arumugam Kalaiselvi

    2014-03-01

    Full Text Available Background: In recent years, the use of chemicals in agriculture, industry, and public health has become so common that the environment is continuously contaminated by the toxic substance-like metals. Aluminum released due to anthropogenic activities such as mining and industrial uses. Aluminium has several industrial uses. The present study was designed to investigate the effect of aluminium chloride (AlCl3 on enzymatic and non-enzymatic antioxidants in the testis and epididymis of rats. Methods: Adult male rats were administered with aluminium chloride at two different doses, 50 mg and 100 mg/kg body weight, orally, daily for 45 days. At the end of the experimental period, the animals were sacrificed and their testis and the epididymis were removed. Antioxidant enzymes like catalase (CAT, superoxide dismutase (SOD, glutathione peroxidase (GPx, glutathione reductase (GR, and glutathione-s-transferase (GST were assayed. Lipid peroxidation (LPO, vitamin C, and vitamin E levels were also determined. Results: Aluminium chloride administration had no effect on the bodyweight of the animals but the weight of the testis and epididymis was decreased. Almost all the antioxidant enzymes studied markedly diminished in the testis and epididymis of aluminium chloride treated animals. The non-enzymatic antioxidants, vitamin C and vitamin E, also declined. Lipid peroxidation, on the other hand, significantly increased. The influence was found to be more in 100 mg treated rats when compared to 50 mg treated rats. Conclusions: The present study suggests the reproductive toxicity of aluminium by inducing the oxidative stress in the testis and epididymis and possible interference in sperm production and further maturational processes.

  8. Transcriptional changes of cytokines in rooster testis and epididymis during sexual maturation stages and Salmonella infection.

    Science.gov (United States)

    Anastasiadou, M; Michailidis, G

    2016-08-01

    Infection of rooster testis and epididymis by pathogens can lead to impaired fertility, resulting in economic losses in the poultry industry. Antimicrobial protection of rooster reproductive organs is, therefore, an important aspect of reproductive physiology. Salmonellosis is one of the most important zoonotic diseases, caused by Salmonella bacteria including Salmonella Enteritidis (SE) and is usually the result of infection of the reproductive organs. Thus, knowledge of the endogenous innate immune mechanisms of the rooster testis and epididymis is an emerging aspect of reproductive physiology. Cytokines are key factors for stimulating the immune response and inflammation in chickens to Salmonella infection. In the present study the expression profile of 11 pro-inflammatory cytokine genes in the rooster testis and epididymis in vivo and transcriptional changes in these organs during sexual maturation and SE infection were investigated. Gene expression analysis data revealed that in both testis and epididymis nine cytokines namely the IL-1β, IL-6, IL-8, IL-10, IL-12, IL-15, IL-16, IL-17 and IL-18 genes were expressed, while no mRNA transcripts were detected in both organs for IL-2 and IL-4. Furthermore, the expression of various cytokine genes during sexual maturation appeared to be developmentally regulated, while SE infection resulted in a significant up-regulation of IL-1β, -6, -12 and -18 genes in the testis and an increase in the mRNA relative abundance of IL-1β, -6, -12, -16 and -18 in the epididymis of SE-infected sexually mature 28-week-old roosters. These results suggest a cytokine-mediated immune response mechanism against Salmonella infection in the rooster reproductive tract. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo.

    Directory of Open Access Journals (Sweden)

    Minyan Li

    Full Text Available Mammalian spermatogenesis is a highly regulated multistage process of sperm generation. It is hard to uncover the real function of a testis specific gene in vitro since the in vitro model is not yet mature. With the development of the CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9 system, we can now rapidly generate knockout mouse models of testis specific genes to study the process of spermatogenesis in vivo. SYCP3-like X-linked 2 (SLX2 is a germ cell specific component, which contains a Cor1 domain and belongs to the XLR (X-linked, lymphocyte regulated family. Previous studies suggested that SLX2 might play an important role in mouse spermatogenesis based on its subcellular localization and interacting proteins. However, the function of SLX2 in vivo is still elusive. Here, to investigate the functions of SLX2 in spermatogenesis, we disrupted the Slx2 gene by using the CRISPR/Cas9 system. Since Slx2 is a testis specific X-linked gene, we obtained knockout male mice in the first generation and accelerated the study process. Compared with wild-type mice, Slx2 knockout mice have normal testis and epididymis. Histological observation of testes sections showed that Slx2 knockout affected none of the three main stages of spermatogenesis: mitosis, meiosis and spermiogenesis. In addition, we further confirmed that disruption of Slx2 did not affect the number of spermatogonial stem cells, meiosis progression or XY body formation by immunofluorescence analysis. As spermatogenesis was normal in Slx2 knockout mice, these mice were fertile. Taken together, we showed that Slx2 itself is not an essential gene for mouse spermatogenesis and CRISPR/Cas9 technique could speed up the functional study of testis specific X-linked gene in vivo.

  10. Effect of varicocelectomy on testis volume and semen parameters in adolescents: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Tie Zhou

    2015-01-01

    Full Text Available Varicocele repair in adolescent remains controversial. Our aim is to identify and combine clinical trials results published thus far to ascertain the efficacy of varicocelectomy in improving testis volume and semen parameters compared with nontreatment control. A literature search was performed using Medline, Embase and Web of Science, which included results obtained from meta-analysis, randomized and nonrandomized controlled studies. The study population was adolescents with clinically palpable varicocele with or without the testicular asymmetry or abnormal semen parameters. Cases were allocated to treatment and observation groups, and testis volume or semen parameters were adopted as outcome measures. As a result, seven randomized controlled trials (RCTs and nonrandomized controlled trials studying bilateral testis volume or semen parameters in both treatment and observation groups were identified. Using a random effect model, mean difference of testis volume between the treatment group and the observation group was 2.9 ml (95% confidence interval [CI]: 0.6, 5.2; P< 0.05 for the varicocele side and 1.5 ml (95% CI: 0.3, 2.7; P< 0.05 for the healthy side. The random effect model analysis demonstrated that the mean difference of semen concentration, total semen motility, and normal morphology between the two groups was 13.7 × 10 6 ml−1 (95% CI: −1.4, 28.8; P = 0.075, 2.5% (95% CI: −3.6, 8.6; P= 0.424, and 2.9% (95% CI: −3.0, 8.7; P= 0.336 respectively. In conclusion, although varicocelectomy significantly improved bilateral testis volume in adolescents with varicocele compared with observation cases, semen parameters did not have any statistically significant difference between two groups. Well-planned, properly conducted RCTs are needed in order to confirm the above-mentioned conclusion further and to explore whether varicocele repair in adolescents could improve subsequently spontaneous pregnancy rates.

  11. Lineaarse kunstiajaloo aeg on otsas / Edit András ; intervjueerinud R[eet] V[arblane

    Index Scriptorium Estoniae

    András, Edit

    2010-01-01

    Vestlus ungari kunstiteoreetiku- ja ajaloolase Edit Andrásiga, kes osales Tallinnas USA Clarki instituudi ja EKA Kunstiteaduste Instituudi seminaril, kus arutati Kesk- ja Ida-Euroopa kunstiajaloo kirjutamisviiside üle. Seminari tekkimisest, kokkusaamise põhjustest, seminari järeldustest, Eesti ja Ungari kunstiajaloo kirjutamise erinevatest põhimõtetest jm.

  12. Earthworm (Clitellata: Megadrili taxonomy in the last 200 years: A homage to András Zicsi (1928−2015

    Directory of Open Access Journals (Sweden)

    Csuzdi, Cs.

    2016-03-01

    Full Text Available Prof. Dr. András Zicsi, the renowned soil biologist and earthworm taxonomist passed away on 22 July, 2015 at the age of 87. To honour his enormous contribution in exploring earthworm biodiversity all over the world, we provide a brief, albeit subjective overview of the history of earthworm taxonomy in the last two century.

  13. The epidemiology and transmissibility of Zika virus in Girardot and San Andres island, Colombia, September 2015 to January 2016

    Science.gov (United States)

    Rojas, DP; Dean, NE; Yang, Y; Kenah, E; Quintero, J; Tomasi, S; Ramirez, EL; Kelly, Y; Castro, C; Carrasquilla, G; Halloran, ME; Longini, IM

    2016-01-01

    Transmission of Zika virus (ZIKV) was first detected in Colombia in September 2015. As of April 2016, Colombia had reported over 65,000 cases of Zika virus disease (ZVD). We analysed daily surveillance data of ZVD cases reported to the health authorities of San Andres and Girardot, Colombia, between September 2015 and January 2016. ZVD was laboratory-confirmed by reverse transcription-polymerase chain reaction (RT-PCR) in the serum of acute cases within five days of symptom onset. We use daily incidence data to estimate the basic reproductive number (R0) in each population. We identified 928 and 1,936 reported ZVD cases from San Andres and Girardot, respectively. The overall attack rate for reported ZVD was 12.13 cases per 1,000 residents of San Andres and 18.43 cases per 1,000 residents of Girardot. Attack rates were significantly higher in females in both municipalities (p < 0.001). Cases occurred in all age groups with highest rates in 20 to 49 year-olds. The estimated R0 for the Zika outbreak was 1.41 (95% confidence interval (CI): 1.15–1.74) in San Andres and 4.61 (95% CI: 4.11–5.16) in Girardot. Transmission of ZIKV is ongoing in the Americas. The estimated R0 from Colombia supports the observed rapid spread. PMID:27452806

  14. Esimene Eesti maja Hiinas = The first Estonian house in China / Andres Põime, Lauri Vaimel ; interv. Triin Ojari

    Index Scriptorium Estoniae

    Põime, Andres

    2008-01-01

    Vestlus Pekingi Eesti saatkonna arhitektuurikonkursi võidutöö autoritega. Tulemused: I preemia - Andres Põime, Lauri Vaimel, II - Erik Nobel, Christian Jensen, Kristen Herup Sovang, Soren Andersson, Pille Kivihall, Dan Ljungar, Hans Willadsen (Taani), III - Kalle Vellevoog, Velle Kadalipp, Tiiu Truus, Martin Prommik

  15. Instrucciones para los autores

    Directory of Open Access Journals (Sweden)

    Revista Facultad de Ingenieria

    2010-12-01

    Full Text Available FACULTAD DE  INGENIERÍA, publicación editada por el Centro de Estudios, de  la Facultad de  Ingeniería  (CEDEC  de  la Universidad Pedagógica  y Tecnológica  de Colombia, Uptc, con una periodicidad semestral, busca contribuir con la difusión delconocimiento científico y el desarrollo  tecnológico producido en el campo de  la  ingeniería, tanto en nuestra facultad, como a nivel regional y nacional.

  16. Acerca de los autores

    OpenAIRE

    2018-01-01

    Diego Aguiar Investigador Adjunto del conicet. Doctor en Ciencias Sociales (flacso). Magíster en Metodología de la Investigación Social (Università degli Studi di Bologna y untref). Licenciado en Sociología (unlp). Profesor Asociado regular en Sociología y Metodología de las Ciencias Sociales (unrn). Profesor de Sociología de la Ciencia y Sociología de la Tecnología y director de la Maestría en Ciencia, Tecnología e Innovación (unrn). Dirige tesis de maestría y doctorado. Director del Centro ...

  17. "Kolossi" autor pole Goya

    Index Scriptorium Estoniae

    2009-01-01

    Hispaania maalikunstniku Francisco de Goya kuulsaim töö "Koloss" kuulutati Madridi Prado muuseumi uurijate poolt Goya assistendi tööks. Muuseumi ekspert Manuela Mena uuris maali röntgenkiirte abil ning avastas kulunud initsiaalid AJ

  18. Carlos Hugo Molina Saucedo. Andrés Ibáñez, un caudillo para el siglo XXI. La Comuna de Santa Cruz de la Sierra de 1876; Andrey Schelchkov. Andrés Ibáñez y la Revolución de la Igualdad en Santa Cruz: primer ensayo de federalismo en Bolivia, 1876-1877

    Directory of Open Access Journals (Sweden)

    Clayton Mendonça Cunha Filho

    2014-11-01

    Full Text Available Carlos Hugo Molina Saucedo. Andrés Ibáñez, un caudillo para el siglo XXI. La Comuna de Santa Cruz de la Sierra de 1876Andrey Schelchkov. Andrés Ibáñez y la Revolución de la Igualdad en Santa Cruz: primer ensayo de federalismo en Bolivia, 1876-1877

  19. L’autorégulation conjointe de la cognition et des émotions : quel impact sur les apprentissages ?

    Directory of Open Access Journals (Sweden)

    Bastien Wagener

    2015-05-01

    Full Text Available Les apprentissages consistent à résoudre des problèmes et à acquérir de nouvelles connaissances et compétences par le biais d’un ensemble de processus relevant de l’autorégulation. Deux aspects principaux rentrent en ligne de compte lorsque l’on cherche à améliorer la résolution de problèmes : la dimension émotionnelle et la métacognition. Les émotions, en tant que réactions organisées et utiles à une situation donnée, peuvent être tour à tour un atout ou un handicap lorsqu’il s’agit d’apprendre. Par ailleurs, la métacognition est constituée d’un ensemble de processus et de savoirs qui s’articulent autour de la prise de conscience et de la régulation de son propre fonctionnement, qu’il soit cognitif ou émotionnel. Grâce aux pratiques de l’attention (PA, issues de traditions permettant un travail sur la conscience et la régulation psychologique et physiologique, il est possible d’agir conjointement sur les cognitions et les émotions. Plusieurs travaux ont montré les nombreux bénéfices que présentent de telles approches et nous constatons également que les effets positifs sur l’autorégulation commencent à être de plus en plus étayés. Nous proposons donc de nouvelles approches holistiques permettant un travail global sur l’autorégulation qui prendraient en compte le traitement métacognitif des sphères cognitive et émotionnelle au bénéfice des apprenants. Simultaneous self-regulation of cognition and emotions and its consequences on learning Abstract: The learning process relies on problem-solving activities and the acquisition of knowledge and skills through self-regulation. Emotions and metacognitions are some of the key aspects that allow the improvement of problem-solving. The emotional dimension consists of structured and useful reactions in regard to a specific situation. Emotions can either be an asset or a disadvantage when one is involved in a learning situation. As for

  20. Maracujá-doce: o autor, a obra e a data da publicação de Passiflora alata (Passifloraceae Sweet-passion-fruit: the autor, data and publication of the scientific name of Passiflora alata (Passifloraceae

    Directory of Open Access Journals (Sweden)

    Luís Carlos Bernacci

    2003-08-01

    Full Text Available O maracujazeiro-doce (Passiflora alata Curtis é uma espécie nativa da América do Sul, especialmente do Brasil, cujo cultivo tem se expandido em função do preço alcançado pelos frutos. Vários trabalhos de pesquisa foram realizados com esta espécie, quase todos com imprecisões na citação do nome científico. Com o objetivo de avaliar a extensão desses equívocos e identificar a forma cientificamente correta de citar a espécie, foram investigados o autor e a data de publicação do nome científico do maracujá-doce, em estudos taxonômicos. Concluiu-se que a espécie deve ser citada como Passiflora alata Curtis, conforme publicado originalmente em 1788, no periódico Botanical Magazine.The author, data and publication of the scientific name of the sweet passion-fruit had been investigated. A series of mistakes occurred in relation to the correct citation of the species. The aim of the present paper was to evaluate the problems and identify the scientific correct form of Passiflora alata nomenclature. The species must be cited as Passiflora alata Curtis and was published originally in 1788, in the Botanical Magazine.

  1. Apología y censura: posibles autores de las crónicas favorables a Pedro I de Castilla

    Directory of Open Access Journals (Sweden)

    González de Fauve, María Estela

    2006-06-01

    Full Text Available

    The present historiography considers that from the times of Pedro I of Castile, favorable stories to this king must have existed which were destroyed after the triumph of the Trastámara dynasty, only interested in making sure a negative picure of the ";Cruel"; king was shown. In this work we have analyzed possible authors of the chronicles called ";true"; versus Ayala's ";false";, as well as the Relación de la vida del Rey D. Pedro attributed to Gracia Dei. The research allows us to conclude that various characteristics attributed to these characters, as well as the authorship of the chronicles they are adscripted to, are part of an advertising campaign started in the sixteenth century by one branch of the Castilla lineage that looks for the reaffirmation as legitimate descendants of Pedro I.



    La historiografía actual considera que, desde la época de Pedro I de Castilla, debieron existir obras favorables a este rey que fueron destruidas, tras el triunfo de la dinastía Trastámara, interesada en que sólo se difundiera una imagen negativa del rey ";Cruel";.En este trabajo analizamos los posibles autores de esas crónicas llamadas “verdaderas” frente a la “fingida” de Ayala, así como la Relación de la vida del Rey D.Pedro... atribuida a Gracia Dei . La investigación nos permite concluir que varias de las características atribuidas a estos personajes, así como la autoría de las crónicas que se les atribuyen, forman parte de una campaña propagandística iniciada en el siglo XVI por una rama del linaje de los Castilla que busca reafirmarse como descendencia legítima de Pedro I.

  2. Effects of estradiol and FSH on maturation of the testis in the hypogonadal (hpg mouse

    Directory of Open Access Journals (Sweden)

    Mayhew Terry M

    2008-01-01

    Full Text Available Abstract Background The hypogonadal (hpg mouse is widely used as an animal model with which to investigate the endocrine regulation of spermatogenesis. Chronic treatment of these GnRH-deficient mice with estradiol is known to induce testicular maturation and restore qualitatively normal spermatogenesis. The aim of the current studies was to investigate whether these effects of estradiol are direct effects in the testis, or indirect actions via paradoxical stimulation of FSH secretion from the pituitary gland. Methods Initially, Western blot and immunohistochemistry were used to analyse tissues from hpg mice to identify potential sites of action of estradiol. In the main study, hpg mice were treated for 50 days with either an estradiol implant or daily injections of recombinant human FSH, or a combination of both, to determine whether estradiol would have an additive or synergistic effect with FSH on testis development, as assessed by histological analysis and stereological quantification of Leydig, Sertoli and germ cell proliferation. Results Western blot analysis revealed ERα immunoreactive bands of appropriate molecular weight in extracts of testis and pituitary glands from hpg mice, and immunohistochemical studies confirmed ERα in nuclei of anterior pituitary cells and Leydig and peritubular cells in hpg mice. Histological and morphometric analyses revealed that estradiol treatment alone was as effective as FSH in promoting Sertoli cell production and proliferation of the seminiferous epithelium, resulting in the production of elongating spermatids. Combined estradiol and FSH treatment did not produce a greater effect than either treatment alone, though an increased dose of FSH significantly increased seminiferous tubule volume and testis weight and increase Sertoli cell numbers further within the same time frame. In contrast, estradiol caused substantial increases in the wet weight of the seminal vesicles, whereas FSH was without effect on

  3. Aspect of the Characters from The Counterfeiters of André Gide

    Directory of Open Access Journals (Sweden)

    Hülya Kol

    2017-07-01

    Full Text Available As a pastry chef, the writer André Gide kneads his dough differently with the intention of putting an end to imitation in the world of the novel. He has the courage to treat the subject of the novel on the contrary to his contemporaries. He succeeds by introducing the reader into the novel. The reader finds fantastic stories and interesting characters in The Counterfeiters. Themes such as the hypocrisy and falsity of these characters are a reflection of the title that evokes them. Gide transmits this problematic period to the reader with surprising skill. The contrast in the words and behaviors of people are the evil traces of war.

  4. Tecnologias digitais: reflexões sobre usos e excessos ilustradas pelos quadrinhos de Andre Dahmer

    Directory of Open Access Journals (Sweden)

    Janaina Cabello

    2015-12-01

    Full Text Available This paper proposes some reflections about possible crossings/impacts on subjective processes from the appropriation of digital technologies in the twenty-first century and how their uses and (alleged excesses have impacted on the subjective constitutions facing other ways humans can show/look/feel/teach, that constitutes the established relationships in the network society. From a historical and cultural perspective, we discuss about the appropriation of digital technologies and the constitutions of subjectivity (individual and in a wider social context, with the backdrop of the illustrations of the Brazilian cartoonist Andre Dahmer, who, through social networks, discloses his work, which provokes and invites us to think about how we relate and therefore, we show and look at ourselves, feel, teach and learn in new subjective configurations with are crossed, constituted and reconstituted by the appropriation of technologies in the contemporary scene.

  5. New Trends in Approximation Theory : in Memory of André Boivin

    CERN Document Server

    Manolaki, Myrto; Gauthier, Paul

    2018-01-01

    The international conference entitled "New Trends in Approximation Theory" was held at the Fields Institute, in Toronto, from July 25 until July 29, 2016. The conference was fondly dedicated to the memory of our unique friend and colleague, André Boivin, who gave tireless service in Canada until his very last moment of his life in October 2014. The impact of his warm personality and his fine work on Complex Approximation Theory was reflected by the mathematical excellence and the wide research range of the 37 participants. In total there were 27 talks, delivered by well-established mathematicians and young researchers. In particular, 19 invited lectures were delivered by leading experts of the field, from 8 different countries. The wide variety of presentations composed a mosaic of aspects of approximation theory, highlighting interesting connections with important contemporary areas of Analysis. Primary topics discussed include application of approximation theory (isoperimetric inequalities, construction of...

  6. André Gide au miroir de la critique : "Corydon" entre œuvre et manifeste

    OpenAIRE

    Abdallah El Sokati , Chahira

    2011-01-01

    Corydon est un essai dans lequel André Gide soutient une nouvelle théorie de l'amour"pédérastique normal". Il y défend sa position tout en esquissant son identité, et en s'efforçantde faire reconnaître celle-ci à travers son oeuvre. Il répond ainsi à l'inquiétude de toute sagénération, ou au moins d'une élite de cette génération. Gide le dit : Corydon est un livre parlequel il veut " gêner ".La thèse suit les transformations de la réception de Corydon depuis sa publication et étudie lesdiffér...

  7. A propósito de don Andrés Bello

    Directory of Open Access Journals (Sweden)

    Carlos Restrepo Canal

    1965-09-01

    Full Text Available Al meditar en estos días sobre el insigne personaje de quien se conmemora el centenario de su fallecimiento -esto es de don Andrés Bello- al analizar su personalidad, estudiada y elogiada por tan autorizados y eruditos escritor es colombianos y extranjeros, al abrir de nuevo los muchos libros que contien en el variado conjunto de sus obras, se llega al convencimiento de que fue Bello como uno de aquellos grandes y brillantes varones del Renacimiento cuyas amplias facultades les hacían aptos para llegar al conocimiento de múltiples y variadas ramas del saber humano y para profundizar en ellas hasta llegar a constituirse en maestros y guías de las generaciones de su tiempo y de las que les sucedieron.

  8. Bioseguridad y armas biológicas:\tLa amenaza de Andrómeda (1971

    Directory of Open Access Journals (Sweden)

    Manuel SÁNCHEZ

    2016-11-01

    Full Text Available La amenaza de Andrómeda es la adaptación cinematográfica de la obra homónima escrita por Michael Crichton. Puede considerarse como la película más “microbiológica” del Séptimo Arte. Dirigida por Robert Wise, este tecno-thriller describe los esfuerzos de un equipo de científicos para caracterizar y contener a un microorganismo patógeno extraterrestre. A pesar de haber sido realizada hace 40 años, se tratan temas de plena actualidad como es el de las armas biológicas, las medidas de aislamiento y protección, la automatización en los procedimientos sanitarios y la toma de decisiones ante una situación grave e inesperada.

  9. The interior capture of life. Le Corbusier and André Malraux

    Directory of Open Access Journals (Sweden)

    Ana Sofía Pereira da Silva

    2016-05-01

    Writings from both authors and architectural projects from Le Corbusier –  Mundial Museum, Mundaneum and Museum of Unlimited Growth- will be observed in order to map the existent affinities between the two authors. However, life’s pragmatic circumstances often oppose what uses to be in accordance. André Malraux’s classification of the Villa Savoye, while he was  Minister of the Cultural Affairs, aimed to save one of Le Corbusier’s  masterpieces. Nevertheless, this action banned the architect the possibility to transform the Villa Savoye into a new program (in a first approach and, finally, excluded him the possibility of authorship of the rehabilitation project, which was subsequently entrusted to an architect working in the National Monuments bureau. This suspected moment of friction between the two authors shall be motive of observation.

  10. Denissen (Frans), André Baillon. Le gigolo d’Irma Idéal

    OpenAIRE

    Gnocchi, Maria Chiara

    2012-01-01

    Un titre aux résonances insolites vient chatouiller la règle sobre des Archives du Futur, la collection publiée sous la responsabilité des Archives et Musée de la Littérature de Bruxelles. André Baillon. Le gigolo d’Irma Idéal : un titre qui convient bien à une biographie que l’on a déjà — à juste titre — qualifiée d’extra-ordinaire (F. Ghysen, Le Carnet et les Instants, novembre 1998). Extra-ordinaire est d’ailleurs, avant tout, le protagoniste du volume : Baillon le grand écrivain, Baillon ...

  11. Edouard Andre (1840-1911, Jardinero-Naturalista y sus viajes por Colombia y el Ecuador

    Directory of Open Access Journals (Sweden)

    Chardon Carlos E.

    1947-06-01

    Full Text Available En la literatura botánica de Colombia y el Ecuador figura ocasionalmente con tono de notable indiferencia el nombre de EDOUARD ANDRÉ, célebre jardinero-naturalista francés, que visitó estos dos países allá por los años de 1875-1876. Por esta razón, los datos biográficos que se incluyen a continuación pueden ser de interés. Los debo principalmente a la exquisita gentileza de MADAME DUPRAT, bibliotecaria del Museo Nacional de Historia Natural, de París, quien recientemente me ha suministrado copia de los datos biográficos de ANDRE, publicados en la Revue horticote (numero del 1o de noviembre de 1911, agotado.

  12. FIFA vaikida ei tohi - Zidane tuleb hukka mõista / Andres Must

    Index Scriptorium Estoniae

    Must, Andres

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 13. juuli, lk. 13. Rahvusvaheline jalgpalliliit võib võtta prantslaselt Zinedine Zidane'ilt vääritu käitumise pärast MMi parima mängija tiitli. Autor kommenteerib, et Zidane'i ja itaallase Marco Materazzi kokkupõrkes oli kahtlemata süüdi just Zidane

  13. Los poetas se negaron a morir: el rol de la autoría en la comunicación literaria

    Directory of Open Access Journals (Sweden)

    Erasto Antonio Espino Barahona

    2002-01-01

    Full Text Available La producción y comprensión del texto literario supone una particular comunicación entre dos sujetos: el autor y el lector. En la misma se ponen en juego problemas humanos fundamentales como lo son la cuestión del otro y del sentido: ¿Para qué escribimos? ¿La labor escritural y lectora puede y debe ayudarnos en nuestra búsqueda de sentido? ¿Cuándo leo, puedo prescindir de la comunicación con ese otro que es el autor y buscarme sólo a mí mismo? El texto intenta responder a estas y otras interrogantes, tomando una distancia crítica frente a algunas posturas teóricas que al explicar la comunicación literaria, minusvaloran la función semiótica del rol del autor.

  14. ANÁLISE DAS METODOLOGIAS DE PLANEJAMENTO E ORGANIZAÇÃO DO TURISMO SEGUNDO OS PRINCIPAIS AUTORES BRASILEIROS

    Directory of Open Access Journals (Sweden)

    Jaqueline dos Santos Silva

    2014-02-01

    Full Text Available Este artigo aborda o tema “planejamento turístico” expondo um estudo analítico sobre as metodologias de planejamento e organização do turismo, publicadas pelos principais autores brasileiros tendo a finalidade de expor seus pontos fortes, pontos fracos, oportunidades, ameaças, dissensões e similitudes. De abordagem qualitativa; utilizou-se a pesquisa bibliográfica e eletrônica; realizaram-se fichamentos de 6 (seis obras selecionadas que foram submetidas a análise SWOT. Assim, este estudo possibilitou a oferta de informações sobre tais metodologias para que estas possam ser utilizadas no planejamento do turismo adequando-se à realidade das destinações turísticas e na intenção de se ampliar o debate sobre a produção teórica acerca do assunto no cenário nacional.

  15. Doncel según Doncel: pensamiento poético y reinvención de autor

    Directory of Open Access Journals (Sweden)

    Fernando Andú Resano

    2017-08-01

    Full Text Available El artículo pretende mostrar la deriva del pensamiento poético de Diego Doncel (Malpartida, Cáceres, 1964 desde la meditación serena de índole filosófico-religiosa característica de sus primeras obras hasta la asunción de una fuerte conciencia crítica social y política en sus últimas entregas. Por encima de la utilización de estrategias antagónicas en la autorrepresentación del yo, un permanente ejercicio de reinvención de autor parece subyacer en el conjunto de la producción lírica de Doncel, tal vez explicable en función de la ironía, reivindicada con insistencia por el poeta extremeño, o, tal vez, para espectadores más escépticos con respecto a una evolución tan singular, simplemente en términos de palinodia.

  16. A TRADUÇÃO DE JOHN DEWEY NA COLEÇÃO AUTORAL BIBLIOTECA DA EDUCAÇÃO

    Directory of Open Access Journals (Sweden)

    Maria Rita de Almeida Toledo

    Full Text Available RESUMO: O artigo analisa o regime de tradução de textos de John Dewey efetuada por Anísio Teixeira, na Biblioteca de Educação (BE, dirigida por Lourenço Filho. Para tanto, descreve-se a materialidade dessa coleção autoral, distinguindo sua fórmula editorial, que instaura, pelo menos em parte, o regime de tradução no qual se processam os textos vertidos para o português. Tal operação historiográfica permite analisar as estratégias de seu editor para atingir os leitores destinatários e apresentar saberes a serem difundidos no campo educacional em um período de disputas de sua (reconfiguração. Para tanto, analisam-se os volumes da coleção, as edições estadunidenses desses textos e a correspondência entre os editores.

  17. EL POSICIONAMIENTO ESTRATÉGICO DEL AUTOR EN ARTÍCULOS DE INVESTIGACIÓN: UNA PROPUESTA PARA SU ESTUDIO

    Directory of Open Access Journals (Sweden)

    Paulina Meza

    2016-01-01

    Full Text Available El Artículo de Investigación se define, frecuentemente, como un texto especializado en el que se comunican los resultados de una investigación. Esta concepción es, a nuestro parecer, neutra e ingenua, pues no da cuenta del hecho de que escribir y publicar un Artículo de Investigación es siempre una acción estratégico–persuasiva: no basta con señalar ciertos resultados, sino que también es fundamental persuadir a la audiencia de su relevancia en el contexto del conocimiento ya establecido, y de que son resultados que merecen ser considerados. Sobre la base de un trabajo de corte teórico, bibliográfico y reflexivo, nuestro objetivo es proponer una alternativa para el estudio del Artículo de Investigación, basada en nuestra concepción del fenómeno. Como principal resultado, proponemos la noción de posicionamiento estratégico del autor como una opción más acabada y exhaustiva para explicar los aspectos sociales y discursivos que subyacen a la transmisión del conocimiento.

  18. Aportes de la sociología al estudio de la educación (Autores clásicos

    Directory of Open Access Journals (Sweden)

    Alexis Rojas-León

    2014-01-01

    Full Text Available Desde sus inicios, la sociología se ha enfocado en el estudio de áreas específicas como lo es la educación, hasta convertirse en una ciencia que profundiza en el estudio científico y especializado del tema. Este documento presenta un repaso de los aportes de diversas tradiciones teóricas europeas acerca de la educación. De los “insumos teóricos” presentados, se desprende la reflexión y la propuesta teórica acerca del objeto de estudio de la sociología de la educación, debido a que en ocasiones parece no haber claridad ni consenso entre los autores. Lo anterior con el fin de analizar aquellos aspectos medulares acerca de la comprensión de las múltiples interacciones entre sociedad-educación y viceversa, visibles desde la sociología. Por último, como una de las principales conclusiones, se argumenta que la tradicionalmente llamada sociología de la educación, engloba la sociología educacional, la sociología educativa y la sociología del sistema educativo. Estas constituyen líneas de investigación de un mismo tema, pero su categorización facilita la especificación de diversos aspectos dentro de un mismo objeto de estudio.

  19. Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer

    DEFF Research Database (Denmark)

    Maheswaran, Emeaga; Pedersen, Christina B; Ditzel, Henrik J

    2015-01-01

    and antigenic properties, but the expression patterns of most of the more than 200 identified cancer/testis antigens in various cancers remain largely uncharacterized. In this study, we investigated the expression of the cancer/testis antigens ADAM2, CALR3 and SAGE1 in lung and breast cancer, the two most...... frequent human cancers, with the purpose of providing novel therapeutic targets for these diseases. We used a set of previously uncharacterized antibodies against the cancer/testis antigens ADAM2, CALR3 and SAGE1 to investigate their expression in a large panel of normal tissues as well as breast and lung...... cancers. Staining for the well-characterized MAGE-A proteins was included for comparison. Immunohistochemical staining confirmed previous mRNA analysis demonstrating that ADAM2, CALR3 and SAGE1 proteins are confined to testis in normal individuals. Negative tissues included plancenta, which express many...

  20. Transcriptome analysis of spermatogenically regressed, recrudescent and active phase testis of seasonally breeding wall lizards Hemidactylus flaviviridis.

    Directory of Open Access Journals (Sweden)

    Mukesh Gautam

    Full Text Available Reptiles are phylogenically important group of organisms as mammals have evolved from them. Wall lizard testis exhibits clearly distinct morphology during various phases of a reproductive cycle making them an interesting model to study regulation of spermatogenesis. Studies on reptile spermatogenesis are negligible hence this study will prove to be an important resource.Histological analyses show complete regression of seminiferous tubules during regressed phase with retracted Sertoli cells and spermatognia. In the recrudescent phase, regressed testis regain cellular activity showing presence of normal Sertoli cells and developing germ cells. In the active phase, testis reaches up to its maximum size with enlarged seminiferous tubules and presence of sperm in seminiferous lumen. Total RNA extracted from whole testis of regressed, recrudescent and active phase of wall lizard was hybridized on Mouse Whole Genome 8×60 K format gene chip. Microarray data from regressed phase was deemed as control group. Microarray data were validated by assessing the expression of some selected genes using Quantitative Real-Time PCR. The genes prominently expressed in recrudescent and active phase testis are cytoskeleton organization GO 0005856, cell growth GO 0045927, GTpase regulator activity GO: 0030695, transcription GO: 0006352, apoptosis GO: 0006915 and many other biological processes. The genes showing higher expression in regressed phase belonged to functional categories such as negative regulation of macromolecule metabolic process GO: 0010605, negative regulation of gene expression GO: 0010629 and maintenance of stem cell niche GO: 0045165.This is the first exploratory study profiling transcriptome of three drastically different conditions of any reptilian testis. The genes expressed in the testis during regressed, recrudescent and active phase of reproductive cycle are in concordance with the testis morphology during these phases. This study will pave

  1. El tratado hacendístico de un autor español del siglo XIX; relevante en sus contenidos contables, novedoso en su exposición

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Villacorta

    2012-07-01

    La novedad es encontrar esta defensa dentro de un texto para reformar la estructura organizativa de la Hacienda Pública española. El objetivo del trabajo consiste en analizar las propuestas del autor para modificar el sector público de aquella época incluidas en su segundo libro denominado “Las doce preguntas relativas a la organización de las oficinas para administrar la Hacienda Nacional”. La conclusión es, que algunas soluciones que el autor plantea para aquellos días, pueden extrapolarse para mejorar la estructura del estado en el momento actual.

  2. Integración de las principales teorías del aprendizaje, y análisis y crítica de los autores estudiados

    OpenAIRE

    Mayorga Muñoz, Esteban; Corporación Universitaria Adventista Cra. 84#33AA-1 Medellín, Colombia, South America A.A. 877. Tel. 2508328; Ruiz López, José Jesús; González Arjona, Aura Graciela

    2017-01-01

    El objetivo de la presente actividad colaborativa es integrar las principales teorías del aprendizaje, analizando y criticando a los autores estudiados. Es una actividad colaborativa. Una vez leídos los documentos asignados, de analizarlos y de realizar búsquedas paralelas que aportaron a los contenidos, se seleccionaron dos de los autores de las teorías del aprendizaje: uno de lospropuestos en el cognitivismo, y uno de los propuestos en el constructivismo. Se reflexionó y centró la atención ...

  3. Validation of endogenous normalizing genes for expression analyses in adult human testis and germ cell neoplasms

    DEFF Research Database (Denmark)

    Svingen, T; Jørgensen, Anne; Rajpert-De Meyts, E

    2014-01-01

    to define suitable normalizing genes for specific cells and tissues. Here, we report on the performance of a panel of nine commonly employed normalizing genes in adult human testis and testicular pathologies. Our analyses revealed significant variability in transcript abundance for commonly used normalizers......, highlighting the importance of selecting appropriate normalizing genes as comparative measurements can yield variable results when different normalizing genes are employed. Based on our results, we recommend using RPS20, RPS29 or SRSF4 when analysing relative gene expression levels in human testis...... and associated testicular pathologies. OCT4 and SALL4 can be used with caution as second-tier normalizers when determining changes in gene expression in germ cells and germ cell tumour components, but the relative transcript abundance appears variable between different germ cell tumour types. We further...

  4. Expression of POTE protein in human testis detected by novel monoclonal antibodies

    International Nuclear Information System (INIS)

    Ise, Tomoko; Das, Sudipto; Nagata, Satoshi; Maeda, Hiroshi; Lee, Yoomi; Onda, Masanori; Anver, Miriam R.; Bera, Tapan K.; Pastan, Ira

    2008-01-01

    The POTE gene family is composed of 13 highly homologous paralogs preferentially expressed in prostate, ovary, testis, and placenta. We produced 10 monoclonal antibodies (MAbs) against three representative POTE paralogs: POTE-21, POTE-2γC, and POTE-22. One reacted with all three paralogs, six MAbs reacted with POTE-2γC and POTE-22, and three MAbs were specific to POTE-21. Epitopes of all 10 MAbs were located in the cysteine-rich repeats (CRRs) motifs located at the N-terminus of each POTE paralog. Testing the reactivity of each MAb with 12 different CRRs revealed slight differences among the antigenic determinants, which accounts for differences in cross-reactivity. Using MAbs HP8 and PG5 we were able to detect a POTE-actin fusion protein in human testis by immunoprecipitation followed by Western blotting. By immunohistochemistry we demonstrated that the POTE protein is expressed in primary spermatocytes, implying a role in spermatogenesis

  5. STEREOLOGICAL QUANTITATION OF LEYDIG AND SERTOLI CELLS IN THE TESTIS FROM YOUNG AND OLD MEN

    Directory of Open Access Journals (Sweden)

    Peter M Petersen

    2011-05-01

    Full Text Available One of the newer stereological methods, the optical fractionator, was applied to the study of the effects of ageing on the human testis. The estimated total number of Sertoli and Leydig cells per testis in men younger than 30 years were 430×106 (CV = SD/mean = 0.35 and 117×106 (CV = 0.53, respectively, while in men older than 50 years the estimated total Sertoli cell number was 266×106 (CV = 0.46 and the mean Leydig cell number 83×106 (CV = 0.53. The difference between the number of Sertoli cells in men younger than 30 years compared with men older than 50 years was close to statistical significance (p = 0.052 while no differences was found in total Leydig cell number (p = 0.22.

  6. Expression and localization of nerve growth factor (NGF in the testis of alpaca (llama pacos

    Directory of Open Access Journals (Sweden)

    Haidong Wang

    2011-04-01

    Full Text Available During alpaca testis development and spermatogenesis, nerve growth factor (NGF may play an importantrole. The main aim of this study was to determine the expression and localization of NGF in the alpacatestis, and to discuss the important role of NGF in alpaca reproductive characteristics. Immunohistochemicalstaining technique and real-time PCR were used. The expression of NGF in the same cells one-month old(newborn alpacas 12-month, and 24-month old alpacas showed significant differences (p 0.05; NGF at different cell stages showed nosignificant differences (p > 0.05. It suggests that NGF may be involved in the regulation of spermatogenesis,which provides direct evidence for NGF action in the alpaca testis during postnatal development and spermatogenesis.

  7. A case of descending colon carcinoma metastasized to left spermatic cord, testis, and epididymis

    Science.gov (United States)

    Augustin, Herbert; Popper, Helmut; Pummer, Karl

    2012-01-01

    We report a case of descending colon carcinoma metastasized to the left spermatic cord, testis, and epididymis. A 77-year old male patient underwent a left hemicolectomy for a descending colon cancer. He was referred to our department because of swelling and pain of the left scrotum two years and six months after surgery. High left orchiectomy was performed. Histological examination revealed a metastasis of the colon carcinoma within the spermatic cord and epididymis approaching the testicle. Reports on metastatic cancer of the testis are scarce, because this metastatic cancer is extremely rare. In general, testicular pain is rare in the elderly. We suggest that any elder presenting with testicular pain deserves a complete clinical and diagnostic evaluation. PMID:24578939

  8. Purification of β-acetylglucosaminase and β-galactosidase from ram testis

    Science.gov (United States)

    Caygill, J. C.; Roston, Christine P. J.; Jevons, F. R.

    1966-01-01

    1. The presence of β-galactosidase (EC 3.2.1.23) in an acetic acid extract of ram testis is reported. Some properties of the crude enzyme preparation were studied. 2. The purification of β-acetylglucosaminase (EC 3.2.1.30) and of β-galactosidase from the ram-testis extract by ammonium sulphate precipitation and chromatography on a CM-cellulose column is described. 3. The final purifications of the separated enzymes achieved were for the β-acetylglucosaminase 35 times and for the β-galactosidase 99 times. 4. The possibility of using DEAE-cellulose and Sephadex G-200 to purify the enzymes was investigated. PMID:5949569

  9. Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility

    Science.gov (United States)

    Bai, Yuhong; Zhang, Yi; Zhang, Jingping; Mu, Qingxin; Zhang, Weidong; Butch, Elizabeth R.; Snyder, Scott E.; Yan, Bing

    2010-09-01

    Soluble carbon nanotubes show promise as materials for in vivo delivery and imaging applications. Several reports have described the in vivo toxicity of carbon nanotubes, but their effects on male reproduction have not been examined. Here, we show that repeated intravenous injections of water-soluble multiwalled carbon nanotubes into male mice can cause reversible testis damage without affecting fertility. Nanotubes accumulated in the testes, generated oxidative stress and decreased the thickness of the seminiferous epithelium in the testis at day 15, but the damage was repaired at 60 and 90 days. The quantity, quality and integrity of the sperm and the levels of three major sex hormones were not significantly affected throughout the 90-day period. The fertility of treated male mice was unaffected; the pregnancy rate and delivery success of female mice that mated with the treated male mice did not differ from those that mated with untreated male mice.

  10. Impaired testicular function in patients with carcinoma-in-situ of the testis

    DEFF Research Database (Denmark)

    Petersen, P M; Giwercman, A; Hansen, S W

    1999-01-01

    for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of 24 patients and no evidence of CIS in the other group of 30 patients. Semen quality and serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were compared in these two groups of men...... after orchidectomy but before further treatment for testicular cancer. RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P ...PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis. PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized...

  11. Ehitatud võrdsus. Tüüpprojekteerimine 20. sajandi elamuehituses : 23. september - 29. oktoober, Eesti Arhitektuurimuuseum, Rotermanni soolaladu / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2000-01-01

    Näitus keskendub linnakorteritele ja -elamutele Eestis, alates 1920. aastate riikliku ehituslaenuga ehitatud korteritest, lõpetades nõukogude perioodi industriaalse massehitusega. Kuraator Andres Kurg, kujundaja arhitektuuribüroo Kolm Pluss Üks

  12. [Epidermoid cyst of the testis difficult to make a preoperative diagnosis on the echoic examination: a case report].

    Science.gov (United States)

    Yamamoto, Keisuke; Takada, Tsuyoshi; Momohara, Chikahiro; Komori, Kazuhiko; Honda, Masahito; Fujioka, Hideki

    2003-04-01

    A case of epidermoid cyst of the testis is presented. The patient was a 64-year-old man who complained of a painless mass in the left scrotum. Physical examination revealed a hen-egg sized enlargement of the left scrotal contents. The ultrasonographic appearance did not show a hyperechoic partition, which is called echogenic rim, a characteristic of this tumor on the echoic examination, and was homogeneous, almost similar to that of a normal testis. Because malignant testicular tumors could not be excluded preoperatively, excisional biopsy of the left testis was performed first. Histological diagnosis was an epidermoid cyst of the testis. As the left testis was almost completely occupied by the tumor and no normal testicular tissue was recognized, we performed orchiectomy additionally. Epidermoid cyst of the testis is a rare benign tumor that accounts for about 1 percent of all testicular tumors. It clinically resembles malignant testicular tumors, and orchiectomy is often performed for treatment. About 154 cases of testicular epidermoid cyst have been reported in the Japanese literature and are reviewed briefly here.

  13. Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xuanchun [Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040 (China); Jiang, Haowen [Department of Urology, Huashan Hospital, Institute of Urology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040 (China); Zhou, Wenbai; Zhang, Zhaoyun; Yang, Zhihong [Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040 (China); Lu, Yong [Department of Urology, Huashan Hospital, Institute of Urology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040 (China); Lu, Bin [Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040 (China); Wang, Xiang [Department of Urology, Huashan Hospital, Institute of Urology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040 (China); Ding, Qiang, E-mail: dingqiangd@hotmail.com [Department of Urology, Huashan Hospital, Institute of Urology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040 (China); Hu, Renming, E-mail: renminghu@fudan.edu.cn [Department of Endocrinology, Huashan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai Medical College, Fudan University, Shanghai 200040 (China)

    2010-03-26

    We reported the identification of a novel gene termed TDRP (encoding testis development-related protein) that might be involved in spermatogenesis. The human TDRP gene had two distinct transcripts, TDRP1 and TDRP2, which encoded proteins of 183 aa and 198 aa respectively. Tdrp mRNA was predominantly expressed in testis tissue. We generated rabbit polyclonal antibodies specific against human TDRP1. Immunohistochemistry analysis showed TDRP1 was expressed in spermatogenic cells, especially with high expression in spermatocytes. We provided evidence that TDRP1 distributed in both cytoplasm and nuclei of spermatogenic cells. Expression patterns of Tdrp1 mRNA and its protein were investigated in the rat testis tissues of different developmental stages. Both Tdrp1 mRNA and its protein were barely detected in the testis of neonatal rats, increased remarkably at 3 weeks postpartum, and peaked at 2 months postpartum. We also investigated TDRP1 expressions in testis tissues of azoospermic men with defective spermatogenesis. Western blot analysis showed that TDRP1 expressions were significantly lower in the testis tissues of azoospermic men compared with normal controls. These current data demonstrated that as a nuclear factor, TDRP1 might play an important role in spermatogenesis.

  14. Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis

    International Nuclear Information System (INIS)

    Wang, Xuanchun; Jiang, Haowen; Zhou, Wenbai; Zhang, Zhaoyun; Yang, Zhihong; Lu, Yong; Lu, Bin; Wang, Xiang; Ding, Qiang; Hu, Renming

    2010-01-01

    We reported the identification of a novel gene termed TDRP (encoding testis development-related protein) that might be involved in spermatogenesis. The human TDRP gene had two distinct transcripts, TDRP1 and TDRP2, which encoded proteins of 183 aa and 198 aa respectively. Tdrp mRNA was predominantly expressed in testis tissue. We generated rabbit polyclonal antibodies specific against human TDRP1. Immunohistochemistry analysis showed TDRP1 was expressed in spermatogenic cells, especially with high expression in spermatocytes. We provided evidence that TDRP1 distributed in both cytoplasm and nuclei of spermatogenic cells. Expression patterns of Tdrp1 mRNA and its protein were investigated in the rat testis tissues of different developmental stages. Both Tdrp1 mRNA and its protein were barely detected in the testis of neonatal rats, increased remarkably at 3 weeks postpartum, and peaked at 2 months postpartum. We also investigated TDRP1 expressions in testis tissues of azoospermic men with defective spermatogenesis. Western blot analysis showed that TDRP1 expressions were significantly lower in the testis tissues of azoospermic men compared with normal controls. These current data demonstrated that as a nuclear factor, TDRP1 might play an important role in spermatogenesis.

  15. Antibacterial and antiviral roles of a fish β-defensin expressed both in pituitary and testis.

    Directory of Open Access Journals (Sweden)

    Jun-Yan Jin

    Full Text Available Defensins are a group of cationic peptides that exhibit broad-spectrum antimicrobial activity. In this study, we cloned and characterized a β-defensin from pituitary cDNA library of a protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides. Interestingly, the β-defensin was shown to be dominantly expressed in pituitary and testis by RT-PCR and Western blot analysis, and its transcript level is significantly upregulated in reproduction organs from intersexual gonad to testis during the natural and artificial sex reversal. Promoter sequence and the responsible activity region analyses revealed the pituitary-specific POU1F1a transcription binding site and testis-specific SRY responsible site, and demonstrated that the pituitary-specific POU1F1a transcription binding site that locates between -180 and -208 bp is the major responsible region of grouper β-defensin promoter activity. Immunofluorescence localization observed its pituicyte expression in pituitary and spermatogonic cell expression in testis. Moreover, both in vitro antibacterial activity assay of the recombinant β-defensin and in vivo embryo microinjection of the β-defensin mRNA were shown to be effective in killing gram-negative bacteria. And, its antiviral role was also demonstrated in EPC cells transfected with the β-defensin construct. Additionally, the antibacterial activity was sensitive to concentrations of Na(+, K(+, Ca(2+ and Mg(2+. The above intriguing findings strongly suggest that the fish β-defensin might play significant roles in both innate immunity defense and reproduction endocrine regulation.

  16. Antibacterial and antiviral roles of a fish β-defensin expressed both in pituitary and testis.

    Science.gov (United States)

    Jin, Jun-Yan; Zhou, Li; Wang, Yang; Li, Zhi; Zhao, Jiu-Gang; Zhang, Qi-Ya; Gui, Jian-Fang

    2010-12-20

    Defensins are a group of cationic peptides that exhibit broad-spectrum antimicrobial activity. In this study, we cloned and characterized a β-defensin from pituitary cDNA library of a protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides). Interestingly, the β-defensin was shown to be dominantly expressed in pituitary and testis by RT-PCR and Western blot analysis, and its transcript level is significantly upregulated in reproduction organs from intersexual gonad to testis during the natural and artificial sex reversal. Promoter sequence and the responsible activity region analyses revealed the pituitary-specific POU1F1a transcription binding site and testis-specific SRY responsible site, and demonstrated that the pituitary-specific POU1F1a transcription binding site that locates between -180 and -208 bp is the major responsible region of grouper β-defensin promoter activity. Immunofluorescence localization observed its pituicyte expression in pituitary and spermatogonic cell expression in testis. Moreover, both in vitro antibacterial activity assay of the recombinant β-defensin and in vivo embryo microinjection of the β-defensin mRNA were shown to be effective in killing gram-negative bacteria. And, its antiviral role was also demonstrated in EPC cells transfected with the β-defensin construct. Additionally, the antibacterial activity was sensitive to concentrations of Na(+), K(+), Ca(2+) and Mg(2+). The above intriguing findings strongly suggest that the fish β-defensin might play significant roles in both innate immunity defense and reproduction endocrine regulation.

  17. Association of Human Development Index with global bladder, kidney, prostate and testis cancer incidence and mortality.

    Science.gov (United States)

    Greiman, Alyssa K; Rosoff, James S; Prasad, Sandip M

    2017-12-01

    To describe contemporary worldwide age-standardized incidence and mortality rates for bladder, kidney, prostate and testis cancer and their association with development. We obtained gender-specific, age-standardized incidence and mortality rates for 184 countries and 16 major world regions from the GLOBOCAN 2012 database. We compared the mortality-to-incidence ratios (MIRs) at national and regional levels in males and females, and assessed the association with socio-economic development using the 2014 United Nations Human Development Index (HDI). Age-standardized incidence rates were 2.9 (bladder) to 7.4 (testis) times higher for genitourinary malignancies in more developed countries compared with less developed countries. Age-standardized mortality rates were 1.5-2.2 times higher in more vs less developed countries for prostate, bladder and kidney cancer, with no variation in mortality rates observed in testis cancer. There was a strong inverse relationship between HDI and MIR in testis (regression coefficient 1.65, R 2 = 0.78), prostate (regression coefficient -1.56, R 2 = 0.85), kidney (regression coefficient -1.34, R 2 = 0.74), and bladder cancer (regression coefficient -1.01, R 2 = 0.80). While incidence and mortality rates for genitourinary cancers vary widely throughout the world, the MIR is highest in less developed countries for all four major genitourinary malignancies. Further research is needed to understand whether differences in comorbidities, exposures, time to diagnosis, access to healthcare, diagnostic techniques or treatment options explain the observed inequalities in genitourinary cancer outcomes. © 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd.

  18. Aspiration and tetracycline sclerotherapy of primary vaginal hydrocoele of testis in adults

    International Nuclear Information System (INIS)

    Ali, J.; Anwar, W.

    2008-01-01

    Primary Vaginal Hydrocoele of Testis is a common condition which is primarily treated surgically. Many patients with Hydrocoele of testis are either not willing or are unfit for surgery. This study was done to know the safety, efficacy and out come of tetracycline induced sclerotherapy of Primary Vaginal Hydrocoele of Testis in adults. This quasi experimental study was done in Shahina Jamil Hospital, attached with Frontier Medical College and Ayub Teaching Hospital, Abbottabad from March 2006 to April, 2007. Thirty-seven patients with primary vaginal hydrocoele were included in the study. Aspiration and instillation of Tetracycline was done after spermatic cord block with 2% lignocaine. Procedure time, Peri and Post-procedure complications, number of injections for cure and patients satisfaction with the procedure were recorded. Patients were discharged home 3 to 4 hours after the procedure and followed up after one week, one month, three months and six months. Direct admission and re-admissions were recorded. The mean age of patients was 47 years. Mean procedure time was 45 minutes. All patients were cured. Mild postoprocedure pain occurred in 12 (40%), moderate pain in 14 (46%) patients and severe pain in 4 (13.3%) patients. No patient developed haematoma or local infection. One patient (3.3%) had micturition problem. Two (6.6%) patients had minimal recurrence. One injection was sufficient for cure in all patients, 28 (93%) patients were satisfied while 2 (6.6%) patients were not satisfied with this procedure. No patient was admitted in the hospital after the procedure. Aspiration and injection of tetracycline in Primary vaginal Hydrocoele of Testis in adults is safe, effective and very economical procedure. (author)

  19. Aspiration and tetracycline sclerotherapy of primary vaginal hydrocoele of testis in adults.

    Science.gov (United States)

    Ali, Johar; Anwar, Waqas; Akbar, Mohammad; Akbar, Syed Ali; Zafar, Arshad

    2008-01-01

    Primary Vaginal Hydrocoele of Testis is a common condition which is primarily treated surgically. Many patients with Hydrocoele of testis are either not willing or are unfit for surgery. This study was done to know the safety, efficacy and out come of tetracycline induced sclerotherapy of Primary Vaginal Hydrocoele of Testis in adults. This quasi experimental study was done in Shahina Jamil Hospital, attached with Frontier Medical College and Ayub Teaching Hospital, Abbottabad from March 2006 to April, 2007. Thirty-seven patients with primary vaginal hydrocoele were included in the study. Aspiration and instillation of Tetracycline was done after spermatic cord block with 2% lignocaine. Procedure time, Peri and Post-procedure complications, number of injections for cure and patients' satisfaction with the procedure were recorded. Patients were discharged home 3 to 4 hours after the procedure and followed up after one week, one month, three months and six months. Direct admission and re-admissions were recorded. The mean age of patients was 47 years. Mean procedure time was 45 minutes. All patients were cured. Mild postoprocedure pain occurred in 12 (40%), moderate pain in 14 (46%) patients and severe pain in 4 (13.3%) patients. No patient developed haematoma or local infection. One patient (3.3%) had micturition problem. Two (6.6%) patients had minimal recurrence. One injection was sufficient for cure in all patients. 28 (93%) patients were satisfied while 2 (6.6%) patients were not satisfied with this procedure. No patient was admitted in the hospital after the procedure. Aspiration and injection of tetracycline in Primary vaginal Hydrocoele of Testis in adults is safe, effective and very economical procedure.

  20. Morphology of the Interstitial Tissue of Active and Resting Testis of the Guinea Fowl

    OpenAIRE

    Dharani, Palanisamy; Kumary, S. Usha; Sundaram, Venkatesan; Joseph, Cecilia; Ramesh, Geetha

    2017-01-01

    SUMMARY: The morphology of the interstitial tissue of sexually active and resting testis of the guinea fowl were studied. Six adult health birds of active and resting phases of reproductive cycle were used for this study. The interstitial tissue consisted of loose connective tissue, interstitial cells (Leydig cells), few connective cells, blood vessels and adrenergic nerve fibres in the present study in both active and resting testes. The interstitial tissue was compact in sexually active tes...

  1. Congenital juvenile granulosa cell tumor of the testis: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Carolina Talini

    2016-07-01

    Full Text Available Juvenile granulosa cell tumor (JGCT is a very rarely diagnosed benign tumor, accounting for 1.2% of all prepubertal testicular tumors. A full-term healthy neonate was diagnosed with a painless left scrotal mass. During evaluation it was identified to have about two times the volume of the contralateral testis, presenting a firm consistency, not as hard as the consistency of a prenatal testicular torsion. Doppler ultrasound detected a multicystic left testicular mass, with normal blood flow, but failed in detecting normal-appearing testis. Human chorionic gonadotropin (β-HCG and serum alpha-fetoprotein (AFP were normal. Inguinal approach was performed, section of the lesion was sent to frozen biopsy and excluded yolk sac tumor, and however the impossibility of detecting normal testis tissue indicated orchiectomy with high ligation of the spermatic cord. Histological evaluation demonstrated gray testicular parenchyma with multicystic aspect fulfilled with yellow fluid. The usual clinical presentation of JGCT is a painless scrotal mass, radiological imaging demonstrates a multicystic tumor. Tumoral markers levels are normal and the standard treatment is the inguinal orchiectomy.

  2. Intravaginal testicular torsion in newborns. To fix or not to fix the contralateral testis?

    Directory of Open Access Journals (Sweden)

    G. Bordin

    2013-10-01

    Full Text Available Scrotal swelling suggesting testicular torsion is a rare urological emergency which requires a clinical urgent evaluation and most of the times must be managed surgically. In newborns it can occur in the postnatal period, usually within the twenty-eighth day of life, or more frequently in utero, during the descent of the testis into the scrotum. Usually its poor fixedness allows the testis an abnormal mobility inside the scrotum, configuring the framework of extravaginal torsion. On the contrary during the perinatal period a twist that takes place inside the tunica vaginalis, known as intravaginal torsion, is extremely uncommon and only few cases are well documented in the literature. Authors present a rare case of intravaginal testicular torsion occurred in perinatal period. In this situation only the early surgical exploration of the scrotum may allow the rescue of the gonad, although in rare cases. Timing of surgical treatment and need for contralateral testicular fixation remain controversial. However since the anatomical defect of the tunica vaginalis can be bilateral the surgical fixation even of the contralateral testis is important, now or later, in order to prevent any future torsion of this gonad. The authors also present a brief review of recent literature on the subject.

  3. Radiation genetic injury and metabolic difference of tritiated thymidine in testis of young and adult mice

    Energy Technology Data Exchange (ETDEWEB)

    Mingyue, Lun; Shoupeng, Zhu

    1990-04-01

    The radiogenetoxicological effects on the adult testis and the metabolic difference of tritiated thymidine between the testis of young and adult BALB/C mice were studied. When 0.037 MBq/g.b.w. of tritiated thymidine was given i.v. to mice, the initial burden of tritium in the adult was larger than that of tritium in the young. But the retention of tritium in testis of the young gradually become larger than that of tritium in the adult with the passing time. Tritiated thymidine which was incorporated into DNA of the male germ cell nuclei damaged the genetic materials and caused the rising of the rates of the dominant lethal and the dominant mutation which produced skeletal abnomalities in the offspring. The relationship between the dominant lethal mutation index (Y) and the injected activity of tritiated thymidine (I, MBq/g.b.w.) is described by Y = 74.13 + 80.20 I (r = 0.95). The relationship between the incidence of the dominant skeletal mutation in the offspring (B) and the injected activity is B = 0.16 + 0.079 I ( r = 0.85).

  4. Radiation genetic injury and metabolic difference of tritiated thymidine in testis of young and adult mice

    International Nuclear Information System (INIS)

    Lun Mingyue; Zhu Shoupeng.

    1990-01-01

    The radiogenetoxicological effects on the adult testis and the metabolic difference of tritiated thymidine between the testis of young and adult BALB/C mice were studied. When 0.037 MBq/g.b.w. of tritiated thymidine was given i.v. to mice, the initial burden of tritium in the adult was larger than that of tritium in the young. But the retention of tritium in testis of the young gradually become larger than that of tritium in the adult with the passing time. Tritiated thymidine which was incorporated into DNA of the male germ cell nuclei damaged the genetic materials and caused the rising of the rates of the dominant lethal and the dominant mutation which produced skeletal abnomalities in the offspring. The relationship between the dominant lethal mutation index (Y) and the injected activity of tritiated thymidine (I, MBq/g.b.w.) is described by Y = 74.13 + 80.20 I (r = 0.95). The relationship between the incidence of the dominant skeletal mutation in the offspring (B) and the injected activity is B = 0.16 + 0.079 I ( r = 0.85)

  5. Protective effects of vitamin E on cyclosporineA-induced toxicity in rat testis

    Directory of Open Access Journals (Sweden)

    Hamidreza Sameni

    2011-07-01

    Full Text Available Introduction: Cyclosporine A (CsA as an immunosuppressive drug which widely used in organ transplantation and autoimmune diseases. This drug is caused many injuries and cell cytotoxic of the body organs such as reproductive organs. The aim of this study was to investigate the possible protective effects of vitamin E (Vit E against CsA-induced damages in rat testis. Material and Methods: 40 adult male wistar rats were divided into 5 groups: control (without any intervention, placebo (received only pure olive oil, test 1 (CsA+olive oil, 30 mg/kg, test 2 (Vit E, 100 mg/kg and test 3 (CsA+Vit E, with the same dose. All animal received drugs for three weeks daily by oral gavages. Following, the testis were fixed and sections stained with Haematoxylin & Eosin and Trichrome Masson. Then with using a microscope equipped with a scaled ocular micrometer and image analysis software were histomorphometry. Results: This study showed that CsA caused severe degenerative changes in testicular tissue include decreased seminiferous tubules diameter, seminiferous epithelium thickness. Also, the number of spermatogonia, primary spermatocyte, spermatozoa, and sertoli and leydig cells significantly decreased throughout the experiment. These changes are lead to turbulence and atrophy seminiferous epithelium and delay in spermatogenesis. Treatment with vitamin E minimized the adverse effects of CsA on testis structure and spermatogenesis. Conclusion: These results suggest that vitamin E has a protective effect against CsA-induced testicular toxicity in male rat.

  6. Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis.

    Directory of Open Access Journals (Sweden)

    Diane Rebourcet

    Full Text Available The Sertoli cells are critical regulators of testis differentiation and development. In the adult, however, their known function is restricted largely to maintenance of spermatogenesis. To determine whether the Sertoli cells regulate other aspects of adult testis biology we have used a novel transgenic mouse model in which Amh-Cre induces expression of the receptor for Diphtheria toxin (iDTR specifically within Sertoli cells. This causes controlled, cell-specific and acute ablation of the Sertoli cell population in the adult animal following Diphtheria toxin injection. Results show that Sertoli cell ablation leads to rapid loss of all germ cell populations. In addition, adult Leydig cell numbers decline by 75% with the remaining cells concentrated around the rete and in the sub-capsular region. In the absence of Sertoli cells, peritubular myoid cell activity is reduced but the cells retain an ability to exclude immune cells from the seminiferous tubules. These data demonstrate that, in addition to support of spermatogenesis, Sertoli cells are required in the adult testis both for retention of the normal adult Leydig cell population and for support of normal peritubular myoid cell function. This has implications for our understanding of male reproductive disorders and wider androgen-related conditions affecting male health.

  7. A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage.

    Science.gov (United States)

    Shan, Chao; Muruato, Antonio E; Jagger, Brett W; Richner, Justin; Nunes, Bruno T D; Medeiros, Daniele B A; Xie, Xuping; Nunes, Jannyce G C; Morabito, Kaitlyn M; Kong, Wing-Pui; Pierson, Theodore C; Barrett, Alan D; Weaver, Scott C; Rossi, Shannan L; Vasconcelos, Pedro F C; Graham, Barney S; Diamond, Michael S; Shi, Pei-Yong

    2017-09-22

    Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues. Vaccinated male mice challenged with Zika virus were protected against testis infection, injury, and oligospermia. A single immunization of rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon challenge. Furthermore, the ZIKV-3'UTR-LAV vaccine candidates have a desirable safety profile. These results suggest that further development of ZIKV-3'UTR-LAV is warranted for humans.Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregnancy in different animal models.

  8. Gene expression profiles in testis of pigs with extreme high and low levels of androstenone

    Directory of Open Access Journals (Sweden)

    Bendixen Christian

    2007-11-01

    Full Text Available Abstract Background: Boar taint is a major obstacle when using uncastrated male pigs for swine production. One of the main compounds causing this taint is androstenone, a pheromone produced in porcine testis. Here we use microarrays to study the expression of thousands of genes simultaneously in testis of high and low androstenone boars. The study allows identification of genes and pathways associated with elevated androstenone levels, which is essential for recognising potential molecular markers for breeding purposes. Results: Testicular tissue was collected from 60 boars, 30 with extreme high and 30 with extreme low levels of androstenone, from each of the two breeds Duroc and Norwegian Landrace. The samples were hybridised to porcine arrays containing 26,877 cDNA clones, detecting 563 and 160 genes that were differentially expressed (p Conclusion: This study contributes to the understanding of the complex genetic system controlling and responding to androstenone levels in pig testis. The identification of new pathways and genes involved in the biosynthesis and metabolism of androstenone is an important first step towards finding molecular markers to reduce boar taint.

  9. Cloning and Characterization of Novel Testis-Specific Diacylglycerol Kinase η Splice Variants 3 and 4.

    Directory of Open Access Journals (Sweden)

    Eri Murakami

    Full Text Available Diacylglycerol kinase (DGK phosphorylates DG to generate phosphatidic acid. Recently, we found that a new alternative splicing product of the DGKη gene, DGKη3, which lacks exon 26 encoding 31 amino acid residues, was expressed only in the secondary spermatocytes and round spermatids of the testis. In this study, we cloned the full length DGKη3 gene and confirmed the endogenous expression of its protein product. During the cloning procedure, we found a new testis-specific alternative splicing product of the DGKη gene, DGKη4, which lacks half of the catalytic domain. We examined the DGK activity and subcellular localization of DGKη3 and η4. DGKη3 had almost the same activity as DGKη1, whereas the activity of DGKη4 was not detectable. In resting NEC8 cells (human testicular germ cell tumor cell line, DGKη1, η3 and η4 were broadly distributed in the cytoplasm. When osmotically shocked, DGKη1 and η4 were distributed in punctate vesicles in the cytoplasm. In contrast, DGKη3 was partly translocated to the plasma membrane and co-localized with the actin cytoskeleton. These results suggest that DGKη3 and η4 have properties different from those of DGKη1 and that they play roles in the testis in a different manner.

  10. The roles of TAM receptor tyrosine kinases in the mammalian testis and immunoprivileged sites.

    Science.gov (United States)

    Deng, Tingting; Chen, Qiaoyuan; Han, Daishu

    2016-01-01

    Three members of a receptor tyrosine kinase family, including Tyro3, Axl, and Mer, are collectively called as TAM receptors. TAM receptors have two common ligands, namely, growth arrest specific gene 6 (Gas6) and protein S (ProS). The TAM-Gas6/ProS system is essential for phagocytic removal of apoptotic cells, and plays critical roles in regulating immune response. Genetic studies have shown that TAM receptors are essential regulators of the tissue homeostasis in immunoprivileged sites, including the testis, retina and brain. The mechanisms by which the TAM-Gas6/ProS system regulates the tissue homeostasis in immunoprivileged sites are emerging. The roles of the TAM-Gas6/ProS system in regulating the immune privilege were intensively investigated in the mouse testis, and several studies were performed in the eye and brain. This review summarizes our current understanding of TAM signaling in the testis and other immunoprivileged tissues, as well as highlights topics that are worthy of further investigation.

  11. Tudor Domain Containing Protein TDRD12 Expresses at the Acrosome of Spermatids in Mouse Testis

    Directory of Open Access Journals (Sweden)

    Min Kim

    2016-07-01

    Full Text Available Tdrd12 is one of tudor domain containing (Tdrd family members. However, the expression pattern of Tdrd12 has not been well studied. To compare the expression levels of Tdrd12 in various tissues, real time-polymerase chain reaction was performed using total RNAs from liver, small intestine, heart, brain, kidney, lung, spleen, stomach, uterus, ovary, and testis. Tdrd12 mRNA was highly expressed in testis. Antibody against mouse TDRD12 were generated using amino acid residues SQRPNEKPLRLTEKKDC of TDRD12 to investigate TDRD12 localization in testis. Immunostaining assay shows that TDRD12 is mainly localized at the spermatid in the seminiferous tubules of adult testes. During postnatal development, TDRD12 is differentially expressed. TDRD12 was detected in early spermatocytes at 2 weeks and TDRD12 was localized at acrosome of the round spermatids. TDRD12 expression was not co-localized with TDRD1 which is an important component of piRNA pathway in germ cells. Our results indicate that TDRD12 may play an important role in spermatids and function as a regulator of spermatogenesis in dependent of TDRD1.

  12. Acetylation-Dependent Chromatin Reorganization by BRDT, a Testis-Specific Bromodomain-Containing Protein

    Science.gov (United States)

    Pivot-Pajot, Christophe; Caron, Cécile; Govin, Jérôme; Vion, Alexandre; Rousseaux, Sophie; Khochbin, Saadi

    2003-01-01

    The association between histone acetylation and replacement observed during spermatogenesis prompted us to consider the testis as a source for potential factors capable of remodelling acetylated chromatin. A systematic search of data banks for open reading frames encoding testis-specific bromodomain-containing proteins focused our attention on BRDT, a testis-specific protein of unknown function containing two bromodomains. BRDT specifically binds hyperacetylated histone H4 tail depending on the integrity of both bromodomains. Moreover, in somatic cells, the ectopic expression of BRDT triggered a dramatic reorganization of the chromatin only after induction of histone hyperacetylation by trichostatin A (TSA). We then defined critical domains of BRDT involved in its activity. Both bromodomains of BRDT, as well as flanking regions, were found indispensable for its histone acetylation-dependent remodelling activity. Interestingly, we also observed that recombinant BRDT was capable of inducing reorganization of the chromatin of isolated nuclei in vitro only when the nuclei were from TSA-treated cells. This assay also allowed us to show that the action of BRDT was ATP independent, suggesting a structural role for the protein in the remodelling of acetylated chromatin. This is the first demonstration of a large-scale reorganization of acetylated chromatin induced by a specific factor. PMID:12861021

  13. Expression dynamics of self-renewal factors for spermatogonial stem cells in the mouse testis.

    Science.gov (United States)

    Sakai, Mizuki; Masaki, Kaito; Aiba, Shota; Tone, Masaaki; Takashima, Seiji

    2018-04-16

    Glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are bona fide self-renewal factors for spermatogonial stem cells (SSCs). Although GDNF is indispensable for the maintenance of SSCs, the role of FGF2 in the testis remains to be elucidated. To clarify this, the expression dynamics and regulatory mechanisms of Fgf2 and Gdnf in the mouse testes were analyzed. It is well known that Sertoli cells express Gdnf, and its receptor is expressed in a subset of undifferentiated spermatogonia, including SSCs. However, we found that Fgf2 was mainly expressed in the germ cells and its receptors were expressed not only in the cultured spermatogonial cell line, but also in testicular somatic cells. Aging, hypophysectomy, retinoic acid treatment, and testicular injury induced distinct Fgf2 and Gdnf expression dynamics, suggesting a difference in the expression mechanism of Fgf2 and Gdnf in the testis. Such differences might cause a dynamic fluctuation of Gdnf/Fgf2 ratio depending on the intrinsic/extrinsic cues. Considering that FGF2-cultured spermatogonia exhibit more differentiated phenotype than those cultured with GDNF, FGF2 might play a role distinct from that of GDNF in the testis, despite the fact that both factors are self-renewal factor for SSC in vitro.

  14. Hyperthyroidism in the developing rat testis is associated with oxidative stress and hyperphosphorylated vimentin accumulation.

    Science.gov (United States)

    Zamoner, Ariane; Barreto, Kátia Padilha; Filho, Danilo Wilhelm; Sell, Fabíola; Woehl, Viviane Mara; Guma, Fátima Costa Rodrigues; Silva, Fátima Regina Mena Barreto; Pessoa-Pureur, Regina

    2007-03-15

    Hyperthyroidism was induced in rats and somatic indices and metabolic parameters were analyzed in testis. In addition, the morphological analysis evidenced testes maturation and intense protein synthesis and processing, supporting the enhancement in vimentin synthesis in hyperthyroid testis. Furthermore, vimentin phosphorylation was increased, indicating an accumulation of phosphorylated vimentin associated to the cytoskeleton, which could be a consequence of the extracellular-regulated kinase (ERK) activation regulating the cytoskeleton. Biomarkers of oxidative stress demonstrated an increased basal metabolic rate measured by tissue oxygen consumption, as well as, increased TBARS levels. In addition, the enzymatic and non-enzymatic antioxidant defences appeared to respond according to the augmented oxygen consumption. We observed decreased total glutathione levels, with enhancement of reduced glutathione, whereas most of the antioxidant enzyme activities were induced. Otherwise, superoxide dismutase activity was inhibited. These results support the idea that an increase in mitochondrial ROS generation, underlying cellular oxidative damage, is a side effect of hyperthyroid-induced biochemical changes by which rat testis increase their metabolic capacity.

  15. Indústria criativa: direitos de autor e acesso à cultura | Creative Industry: copyrights and access to culture

    Directory of Open Access Journals (Sweden)

    Antônio Márcio Buainain

    2011-10-01

    Full Text Available Resumo O artigo tem por objetivo apresentar uma breve reflexão sobre a indústria criativa – pontuando sua gênese, evolução, delimitação de seu objeto e atividades que a compõem – e o acesso aos bens culturais. Reconhece-se a importância da lei de direitos autorais como marco básico para o funcionamento e crescimento sustentável e harmônico da indústria criativa, mas aqui se argumenta, com base no amplo levantamento feito pelo IBGE, que as dificuldades de acesso à cultura enfrentadas pela maioria da população brasileira são pouco relacionadas às falhas da legislação autoral. Para tanto, o artigo contem duas partes. Na primeira se apresenta a indústria criativa, tendo como base as metodologias que a Conferência das Nações Unidas para Comércio e Desenvolvimento (UNCTAD e a Organização Mundial da Propriedade Intelectual (OMPI utilizam para delimitar a importância socioeconômica desta indústria. Na segunda resumem-se informações do Suplemento de Cultura da Pesquisa de Informações Básicas Municipais (MUNIC-IBGE, de 2006, procurando indicar a precariedade das condições de acesso à cultura na maior parte do território nacional. As conclusões apontam que, a despeito da lei autoralista ser imperfeita e incompleta – características imanentes de leis que não conseguem acompanhar o dinamismo dos avanços sociais e tecnológicos –, ela não obsta de todo o acesso a bens culturais; fatores de ordem pessoal e material contribuem para o maior ou menor acesso a estes bens, tais como nível educacional, políticas públicas, fomento do governo na área da cultura, disponibilidade de bens culturais públicos e infraestrutura de cultura. Palavras-chave indústria criativa, acesso à cultura, lei de direito autoral Abstract The article presents an overview of the creative industries and access to cultural goods in Brazil. The copyright laws are relevant but insufficient for the development of this industry. To the

  16. Los autores como actores en el teatro experimental español de los años veinte

    Directory of Open Access Journals (Sweden)

    Fraga Fernández-Cuevas, María Jesús

    2010-06-01

    Full Text Available During the attempts for theatrical renewal in the twenties, several playwrights worked also as actors. The Baroja’s acted in the company ‘El Mirlo Blanco’; D. Pío participation was enthusiastic although brief, while his brother Ricardo was better recognized for his work as stage designer. Rivas Cherif participated in numerous performances and his coherence with the new theatre model that he defended was unanimously praised. Eusebio de Gorbea was considered the best actor among the playwrights, although his more appreciated characteristics like tone, gesture and roughness approached him to naturalism. The interpretative work of these authors as components of a group, whose nucleus remained amongst successive renovation attempts, is also recognized by its discipline, renounce to individual success and subordination to scenic treatment.En los ensayos de renovación teatral de los años veinte, varios dramaturgos intervinieron como actores. Los hermanos Baroja actuaron en la compañía ‘El Mirlo Blanco’: la participación de D. Pío fue entusiasta pero breve; de su hermano Ricardo se recuerda con mayor interés su labor de escenógrafo. Las numerosas actuaciones de Rivas Cherif fueron unánimemente valoradas por su coherencia con los presupuestos del nuevo teatro que tanto defendió. Eusebio de Gorbea fue el dramaturgo más reconocido en su labor de actor, si bien sus rasgos más destacados, tono, ademán, rudeza le sitúan cercano al naturalismo. La labor interpretativa de estos autores como componentes de un grupo, cuyo núcleo se mantiene en los sucesivos intentos renovadores, es también alabada por su disciplina, renuncia al lucimiento y supeditación al tratamiento escénico.

  17. El análisis económico del derecho de autor y del copyright, un estudio del equilibrio entre los intereses público y privado

    Directory of Open Access Journals (Sweden)

    Ana María Pérez Gómez Tétrel

    2007-01-01

    Full Text Available La propiedad intelectual ha sido concebida para responder, tanto a la necesidad de protección del autor de una obra del intelecto, como al beneficio que la sociedad pueda sacar del acceso a dichas creaciones intelectuales, generando así un equilibrio entre los diferentes actores. Los sistemas digitales de comunicación han puesto en jaque dicho equilibrio. Conviene preguntarse ¿es capaz la protección otorgada por el derecho a la creación intelectual, de establecer un equilibrio en las relaciones entre creador (autor y la sociedad (consumidor? ¿En qué medida el análisis económico comparado del derecho de autor y del copyright puede contribuir al modelo económico de este equilibrio? ¿Hasta qué punto, el rol desempeñado por las industrias de la comunicación está rompiendo este equilibrio? El objetivo de este artículo es analizar diversos aspectos del derecho de autor y del copyright, a la luz del análisis económico del derecho.

  18. El análisis económico del derecho de autor y del copyright, un estudio del equilibrio entre los intereses público y privado

    Directory of Open Access Journals (Sweden)

    Ana María Pérez Gómez Tétrel

    2007-11-01

    Full Text Available La propiedad intelectual ha sido concebida para responder, tanto a la necesidad de protección del autor de una obra del intelecto, como al beneficio que la sociedad pueda sacar del acceso a dichas creaciones intelectuales, generando así un equilibrio entre los diferentes actores. Los sistemas digitales de comunicación han puesto en jaque dicho equilibrio. Conviene preguntarse ¿es capaz la protección otorgada por el derecho a la creación intelectual, de establecer un equilibrio en las relaciones entre creador (autor y la sociedad (consumidor? ¿En qué medida el análisis económico comparado del derecho de autor y del copyright puede contribuir al modelo económico de este equilibrio? ¿Hasta qué punto, el rol desempeñado por las industrias de la comunicación está rompiendo este equilibrio? El objetivo de este artículo es analizar diversos aspectos del derecho de autor y del copyright, a la luz del análisis económico del derecho.

  19. La tutela efectiva de la creación de contenidos e-learning: una solución en las excepciones al derecho de autor

    OpenAIRE

    López Rodríguez, Fernando; Peire Arroba, Juan

    2015-01-01

    La evolución de la tecnología ha llevado, necesariamente, a un desarrollo de los derechos de autor y de la Propiedad Intelectual. Estas evidencias se refieren a la relevancia por la puesta en funcionamiento de las plataformas tecnológicas en relación

  20. Psühhiaater: "Alkohol jääb meie suurimaks probleemiks" / Andres Lehtmets ; intervjueerinud Tiina Jõgeda

    Index Scriptorium Estoniae

    Lehtmets, Andres

    2010-01-01

    Autor kritiseerib Tervise Arengu Instituudi "Eesti tervisestatistika raamatu" (2005-2008) tõlgendamist. Psüühika- ja käitumishäirete kasvust, mis on sõltuvuses uimastite ja alkoholi tarbimisest. Diagramm

  1. Hotell 'Bernhard' Otepääl. Otepää aedlinn, Kolga tee 22a / Andres Lunge

    Index Scriptorium Estoniae

    Lunge, Andres

    1998-01-01

    Otepää aedlinnas asuva U. Tiirmaa poolt kuuekümnendatel projekteeritud Tartu Katseremonditehase puhkebaasi rekonstrueerimine. Kavandati uus peasissepääs, täiendav tubadekorrus, restoran, vastuvõtufuajee jm. ning juurdeehitusena osaliselt maaalune lisakorpus konverentsisaali jm. ruumidega. Tellija: AS Regel. Projekteerija: Tareke Projekt OÜ. Arhitekt Andres Lunge. Sisekujundaja Taisi Kadarik. Ehitus: AS Regel, 1996-1998. Projekt 1995, 1998, valmis 1998

  2. De los recursos didácticos para el aula a los contenidos para espacios virtuales educativos con componentes activos y herramientas de autor

    Directory of Open Access Journals (Sweden)

    Francisco José García Peñalvo

    2004-01-01

    Full Text Available El uso de las Tecnologías de la Información y la Comunicación en los procesos educativos en general, y en la Universidad en particular, comienza a ser una realidad, al menos en apariencia y en infraestructura. Es cotidiano el uso de medios audiovisuales como apoyo a la tradicional lección magistral, así como la publicación de diversos materiales en diversos sitios web relacionados con la docencia. Sin embargo, un análisis más profundo de la situación quizás nos lleve a una realidad menos alentadora, donde el conjunto de los autores de contenidos didácticos no reúne todo el potencial humano que la Universidad podría ofrecer. En consecuencia el número de materiales didácticos se ve afectado negativamente, de modo que la calidad, organización y accesibilidad de los mismos es susceptible de importantes mejoras. Desde este artículo, apoyándonos en las experiencias desarrolladas en el Laboratorio de Diseños Educativos Multimedia y Teleeducación del Instituto de Ciencias de la Educación de la Universidad de Salamanca, se aboga por la necesidad de superar la mera creación de elementos docentes aislados y caminar hacia el establecimiento efectivo de verdaderos espacios virtuales educativos, que deberían estar soportados por componentes educativos activos y herramientas de autor para la población de dichos espacios con contenidos de calidad. En el caso de las herramientas de autor, defendemos que las interfaces autor-herramienta han de estar pensadas para facilitar el acercamiento como autores de contenidos a un personal que no tiene por qué ser experto en informática

  3. Distribution and infestation levels of Crypticerya multicicatrices Kondo and Unruh (Hemiptera: Monophlebidae on San Andrés island

    Directory of Open Access Journals (Sweden)

    Takumasa Kondo Kondo

    2014-01-01

    Full Text Available The fluted scale Crypticerya multicicatrices (Hemiptera: Monophlebidae is an invasive insect that became a major pest on the island of San Andrés. To generate control strategies for this insect, its distribution and infestation levels on palm species, fruit trees, leguminous trees and other plant species were determined during January 14–18, 2013. A total of 96 points were sampled in order to determine the distribution of the insect on the island. During the study, the fluted scale was found distributed throughout the island of San Andrés, including Haynes Cay and Johnny Cay. The palms were the plants with the highest levels of infestation, 70.8% had some degree of infestation (37.5% high infestation levels; followed by fruit trees which had 65.6% with some degree of infestation (30.2% high infestation levels; followed by leguminous trees which had 59.6% with some degree of infestation (13.5% high infestation levels and finally “other hosts” which had 51.1% with some level of infestation (11.5% high infestation levels. This study is the first detailed mapping of C. multicicatrices on the island of San Andrés which will become the basis for future work on the population dynamics of the fluted scale and its distribution on the island.

  4. Puentes de Saint-André-de-Cubzac y de Angers Francia

    Directory of Open Access Journals (Sweden)

    Mathivat, J.

    1978-02-01

    Full Text Available The development of the technique of prefabricated voussoir bridges during the past years has been made possible by the progress achieved in various fields which are developed here, namely: 1 the improvement of the joint between arch stones by the adoption of multiplenotch joints where the adhesive plays a less important part, 2 the increase ín the cross dimensions of the voussoirs as well as in their unit weight, which reduces the number of joints, as well as the diversification of the forms, which can lead to the elimination of the cross prestress, 3 the improvement of the methods of placing and of the design of the lifting rigs: mobile lifting equipement carried by the deck, launching girder. The study of these different factors is supplemented and illustrated by the presentation of two recent works: the freeway bridges of Saint-André-de-Cubzac and the bridge on the Loire near Angers.

    El desarrollo de la técnica de los puentes de dovelas prefabricadas ha experimentado un fuerte incremento, durante los últimos años, a causa de: 1 Mejoramiento de las juntas entre dovelas, por adopción de sistemas dotados de dentado múltiple, en cuyo caso el papel de la cola es menos primordial. 2 Aumento de las dimensiones transversales de las dovelas, así como de su peso unitario, lo cual reduce el número de juntas, así como la diversificación de las formas, con lo cual se puede conseguir la supresión del pretensado transversal. 3 Mejoras introducidas en los métodos de colocación y en el diseño de los aparatos de elevación: equipo móvil de elevación soportado por el propio tablero, viga de lanzamiento. El estudio de estos distintos factores se ha ilustrado con la presentación de dos obras recientemente ejecutadas, a saber: los puentes de autopista de Saint-André-de-Cubzac y el puente del Loira, cerca de Angers.

  5. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins

    International Nuclear Information System (INIS)

    Cao Qinhong; Chen Jie; Zhu Li; Liu Yun; Zhou Zuomin; Sha Jiahao; Wang Shui; Li Jianmin

    2006-01-01

    Tumor protein D52-like proteins (TPD52) are small coiled-coil motif bearing proteins that were first identified in breast cancer. TPD52 and related proteins have been implicated in cell proliferation, apoptosis, and vesicle trafficking. To date, three human TPD52 members had been identified, named hD52 (TPD52), hD53 (TPD52L1), and hD54 (TPD52L2). The most important characteristic of the protein family is a highly conserved coiled-coil motif that is required for homo- and heteromeric interaction with other TPD52-like proteins. Herein, we identified a novel TPD52-like sequence (TPD52L3, or hD55) in human testis using cDNA microarray. Sequence analysis of the deduced protein suggests that hD55 contains a coiled-coil motif and is highly conserved compared with other TPD52-like sequences. Yeast two-hybrid and GST pull-down assays revealed that hD55 interacts with hD52, hD53, hD54, and itself. cDNA microarray detection found that hD55 was expressed at 5.6-fold higher levels in adult testis than in fetal testis. Additionally, the expression profile shows that hD55 is testis-specific, indicating a potential role for hD55 in testis development and spermatogenesis

  6. Study on the abnormalities in sperm and gene mutation induced by retention of {sup 147}Pm in testis

    Energy Technology Data Exchange (ETDEWEB)

    Shoupeng, Zhu; Mingyue, Lun; Shuqin, Yang [Suzhou Medical Coll., JS (China)

    1990-05-01

    The purpose of the present study is to ascertain {sup 147}Pm retention in testis and its radiogenotoxicological effects of gene mutation through varying radioactivities of internal exposure. Especially the accumulation of {sup 147}Pm in testis induces the dominant lethal, dominant skeletal mutation and abnormalities in sperm. Studies indicated that the cumulative absorption dose in testis increases as the internal exposure of {sup 147}Pm increases. The internal exposure of {sup 147}Pm can destroy the genetic materials and raise the rates of dominant lethal and dominant mutation of skeletal abnormalities in the offspring. The relationship between the rate of dominant skeletal mutation (B) and accumulated radioactivities of {sup 147}Pm (D) in testis can be described by a linear equation that is B 20.68 + 35.48 D. The relationship between abnormalities of the sperm and the cumulative dose from {sup 147}Pm in testis can be expressed by the following equation: S = 10.8705 D{sup 0.5224} + 3.1768.

  7. Adenocarcinoma of the rete testis with prominent papillary structure and clear neoplastic cells: Morphologic and immunohistochemical findings and differential diagnosis

    Directory of Open Access Journals (Sweden)

    Pei-Wen Huang

    2015-01-01

    Full Text Available Adenocarcinoma of the rete testis is rare, and its etiology is unknown. The definite diagnosis merely depends on the exclusion of other tumors and histological features. We first describe a 38-year-old man with a carcinoma arising in the rete testis. The tumor was characterized by clear neoplastic cells and branching papillary growth. Focal stromal invasion and transition of normal rete epithelium to neoplastic cells were seen. The neoplastic cells were positive for epithelial membrane antigen, Ber-Ep4, vimentin, renal cell carcinoma marker, and CD10, while negative for Wilms′ tumor 1, thyroid transcription factor-1, estrogen receptor, prostate specific antigen, placental alkaline phosphate, CD117, and alpha-1-fetoprotein. According to the above features, we diagnosed this tumor as adenocarcinoma of the rete testis. To our best knowledge, this is the first reported case of adenocarcinoma of the rete testis with prominently papillary structure and clear neoplastic cells. The rarity of adenocarcinoma of the rete testis and the unique features in our case cause diagnostic pitfalls. A complete clinicopathological study and thorough differential diagnosis are crucial for the correct result.

  8. Drive-induced delocalization in the Aubry-André model

    Science.gov (United States)

    Ray, S.; Ghosh, A.; Sinha, S.

    2018-01-01

    Motivated by the recent experiment by Bordia et al. [Nat. Phys. 13, 460 (2017), 10.1038/nphys4020], we study the single particle delocalization phenomena of the Aubry-André (AA) model subjected to periodic drives. In two distinct cases we construct an equivalent classical description to illustrate that the drive-induced delocalization phenomena stems from an instability and the onset of chaos in the underlying dynamics. In the first case we analyze the delocalization and the thermalization in a time modulated AA potential with respect to driving frequency and demonstrate that there exists a threshold value of the amplitude of the drive. In the next example, we show that the periodic modulation of the phase of the hopping amplitude induced by a gauge field leads to an unusual effect on delocalization with a nonmonotonic dependence on the driving frequency. Within a window of such a driving frequency a delocalized Floquet band with a mobility edge appears, exhibiting multifractality in the spectrum as well as in the Floquet eigenfunctions. Finally, we explore the effect of interaction and discuss how the results of the present analysis can be tested experimentally.

  9. Chemical Profile and Antioxidant Activity of the Oil from Peony Seeds (Paeonia suffruticosa Andr.

    Directory of Open Access Journals (Sweden)

    Xin Yang

    2017-01-01

    Full Text Available Peony seed oil (PSO is a novel vegetable oil developed from the seeds of Paeonia suffruticosa Andr. The present study aimed to make an overall investigation on the chemical profile and antioxidant activities of PSO for reasonable development and utilization of this new resource food. Chemical analysis revealed that PSO was characterized by an uncommon high portion of α-linolenic acid (>38%, fairly low ratio of n-6 to n-3 polyunsaturated fatty acids (0.69, and much higher content of γ-tocopherol than various conventional seed oils. In vitro assay indicated that PSO is a more potent scavenger of free radicals than extra virgin olive oil. Moderate intake of PSO exhibited obvious protection against various oxidative damages such as tetrachloromethane-induced acute liver injury in mice and diet-induced hyperlipidemia in rats. The changes in the key indicators of oxidative injury and fatty acid composition in the liver caused by PSO administration were measured, and the results demonstrated that antioxidant properties of PSO are closely related to their characteristic chemical composition. Consequently, the present study provided new evidence for the health implications of PSO, which deserves further development for medical and nutritional use against oxidative damages that are associated with various diseases.

  10. Karl Andrée (1880-1959) sedimentologist and marine geologist

    Science.gov (United States)

    Dullo, Wolf-Christian; Pfaffl, Fritz A.

    2017-09-01

    Karl Andrée began studying questions of sedimentology and oceanography in 1908 when working as an assistant at the University of Marburg and he remained faithful to these subjects until his death in 1959. The vast majority of his scientific contributions, however, were published during his time at the University of Königsberg (1915-1945). There he published his fundamental papers on marine geology, all of which adhered strictly to the principles of uniformitarianism, and helped improve our understanding of sedimentary processes and the stratigraphic record. His scientific work has enormous breadth. In the course of 55 years, he published 124 individual papers and books, some of which became classic textbooks. His versatility is particularly evident in his book "Geology of the Seafloor", which contains many pertinent observations and descriptions still relevant today, even if it has fallen out of fashion. This scientist and university teacher was the first to successfully present the huge field of marine geology in all its facet and to consider the deposition of marine sediments as a function of their geographical distribution.

  11. san Andrés, Pinar del Río, Cuba

    Directory of Open Access Journals (Sweden)

    N. Valdés-Rodriguez

    2006-01-01

    Full Text Available El presente trabajo se realizó en la Unidad Forestal San Andrés, en el área que corresponde a las alturas de pizarras, tuvo como objetivo realizar una valoración de diferentes aspectos de su morfología y el endemismo de las especies de plantas leñosas acompañantes en los ecosistemas de pinares naturales presentes en esa zona. Para realizar esta valoración se tomaron en cuenta aspectos como el tipo biológico, la textura de la hoja, el tamaño de la planta, la distribución de la especie y la familia de las especies recolectadas en las zonas de muestreo. Se llegó a la conclusión de que la vegetación acompañante se caracteriza por ser especies de pequeño a mediano tamaño, con hojas medianamente pequeñas, y que no existe entre estas especies ninguna endémica a nivel de distrito o local.

  12. Mechanisms of the Testis Toxicity Induced by Chronic Exposure to Mequindox

    Directory of Open Access Journals (Sweden)

    Qianying Liu

    2017-09-01

    Full Text Available Mequindox (MEQ is a synthetic antimicrobial agent widely used in China since the 1980s. Although the toxicity of MEQ is well recognized, its testis toxicity has not been adequately investigated. In the present study, we provide evidence that MEQ triggers oxidative stress, mitochondrion dysfunction and spermatogenesis deficiency in mice after exposure to MEQ (0, 25, 55, and 110 mg/kg in the diet for up to 18 months. The genotoxicity and adrenal toxicity may contribute to sperm abnormalities caused by MEQ. Moreover, using LC/MS-IT-TOF analysis, two metabolites, 3-methyl-2-(1-hydroxyethyl quinoxaline-N4-monoxide (M4 and 3-methyl-2-(1-hydroxyethyl quinoxaline-N1-monoxide (M8, were detected in the serum of mice, which directly confirms the relationship between the N→O group reduction metabolism of MEQ and oxidative stress. Interestingly, only M4 was detected in the testes, suggesting that the higher reproductive toxicity of M4 than M8 might be due to the increased stability of M4-radical (M4-R compared to M8-radical (M8-R. Furthermore, the expression of the blood-testis barrier (BTB-associated junctions such as tight junctions, gap junctions and basal ectoplasmic specializations were also examined. The present study demonstrated for the first time the role of the M4 in testis toxicity, and illustrated that the oxidative stress, mitochondrion dysfunction and interference in spermatogenesis, as well as the altered expression of BTB related junctions, were involved in the reproductive toxicity mediated by MEQ in vivo.

  13. White tea intake prevents prediabetes-induced metabolic dysfunctions in testis and epididymis preserving sperm quality.

    Science.gov (United States)

    Dias, Tânia R; Alves, Marco G; Rato, Luís; Casal, Susana; Silva, Branca M; Oliveira, Pedro F

    2016-11-01

    Prediabetes has been associated with alterations in male reproductive tract, especially in testis and epididymis. Moreover, in vitro studies described a promising action of tea (Camellia sinensis L.) against metabolic dysfunctions. Herein, we hypothesized that white tea (WTEA) ingestion by prediabetic animals could ameliorate the metabolic alterations induced by the disease in testicular and epididymal tissues, preserving sperm quality. WTEA infusion was prepared and its phytochemical profile was evaluated by 1 H-NMR. A streptozotocin-induced prediabetic rat model was developed and three experimental groups were defined: control, prediabetic (PreDM) and prediabetic drinking WTEA (PreDM+WTEA). Metabolic profiles of testis and epididymis were evaluated by determining the metabolites content ( 1 H-NMR), protein levels (western blot) and enzymatic activities of key metabolic intervenient. The quality of spermatozoa from cauda epididymis was also assessed. Prediabetes increased glucose transporter 3 protein levels and decreased lactate dehydrogenase activity in testis, resulting in a lower lactate content. WTEA ingestion led to a metabolic adaptation to restore testicular lactate content. Concerning epididymis, prediabetes decreased the protein levels of several metabolic intervenient, resulting in decreased lactate and alanine content. WTEA consumption restored most of the evidenced alterations, however, not lactate content. WTEA also improved epididymal sperm motility and restored sperm viability. Prediabetes strongly affected testicular and epididymal metabolic status and most of these alterations were restored by WTEA consumption, resulting in the improvement of sperm quality. Our results suggest that WTEA consumption can be a cost-effective strategy to improve prediabetes-induced reproductive dysfunction. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. The short term effects of resveratrol on ischemia-reperfusion injury in rat testis.

    Science.gov (United States)

    Yuluğ, Esin; Türedi, Sibel; Karagüzel, Ersagun; Kutlu, Omer; Menteşe, Ahmet; Alver, Ahmet

    2014-03-01

    The purpose of this study was to identify changes taking place in the rat testis at the 24th hour of reperfusion following testicular torsion and to evaluate the effects of resveratrol (RSV), a powerful antioxidant, in preventing these changes using novel biochemical parameters and histopathology. Eighteen adult male rats were divided into three groups: Sham-operated (S), torsion/detorsion (T/D), and T/D+RSV groups. In the T/D group, testicular ischemia was achieved by rotating the left testis 720° clockwise for 4h. In the T/D+RSV group, 20mg/kg RSV was administered intraperitoneally 30 min before detorsion. All rats were sacrificed 24h after detorsion. Serum and tissue malondialdehyde (MDA) concentrations, ischemia modified albumin (IMA), total oxidative status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and histopathological damage score were analyzed. Serum MDA, IMA, TOS, and OSI levels rose significantly in the T/D group. Serum MDA and IMA values were lower in the T/D+RES groups, but not significantly. OSI and TOS values were lower in the T/D+RES group, and the difference was significant. TAS values decreased significantly in the T/D group and rose in the T/D+RSV group, but not significantly. Ipsilateral tissue MDA values were significantly elevated in the T/D group and decreased in the T/D+RSV group, but not significantly. Apoptosis and histopathological damage increased significantly in the T/D group and decreased significantly in the T/D+RSV group. In the contralateral testis, apoptosis increased significantly in the T/D group. It decreased significantly in the T/D+RSV group. Our findings show that RSV had a protective effect against oxidative damage induced with a testicular T/D model, especially at the antiapoptotic and histopathological level. OSI may be a good guide to the clinical status of testicular T/D. © 2014.

  15. Marital status independently predicts testis cancer survival--an analysis of the SEER database.

    Science.gov (United States)

    Abern, Michael R; Dude, Annie M; Coogan, Christopher L

    2012-01-01

    Previous reports have shown that married men with malignancies have improved 10-year survival over unmarried men. We sought to investigate the effect of marital status on 10-year survival in a U.S. population-based cohort of men with testis cancer. We examined 30,789 cases of testis cancer reported to the Surveillance, Epidemiology, and End Results (SEER 17) database between 1973 and 2005. All staging were converted to the 1997 AJCC TNM system. Patients less than 18 years of age at time of diagnosis were excluded. A subgroup analysis of patients with stages I or II non-seminomatous germ cell tumors (NSGCT) was performed. Univariate analysis using t-tests and χ(2) tests compared characteristics of patients separated by marital status. Multivariate analysis was performed using a Cox proportional hazard model to generate Kaplan-Meier survival curves, with all-cause and cancer-specific mortality as the primary endpoints. 20,245 cases met the inclusion criteria. Married men were more likely to be older (38.9 vs. 31.4 years), Caucasian (94.4% vs. 92.1%), stage I (73.1% vs. 61.4%), and have seminoma as the tumor histology (57.3% vs. 43.4%). On multivariate analysis, married status (HR 0.58, P married status (HR 0.60, P married and unmarried men (44.8% vs. 43.4%, P = 0.33). Marital status is an independent predictor of improved overall and cancer-specific survival in men with testis cancer. In men with stages I or II NSGCT, RPLND is an additional predictor of improved overall survival. Marital status does not appear to influence whether men undergo RPLND. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Molecular cloning and characterization of Izumo1 gene from bovine testis

    OpenAIRE

    Kim, Ekyune

    2015-01-01

    A well-characterized sperm specific protein of the Member of immunoglobulin superfamily, IZUMO1, has crucial role in fertilization by mediating sperm binding to the egg plasma membrane in the mouse. However little is known about IZUMO1 in bovine. Here, we describe the molecular cloning and expression analysis of bovine IZUMO1 (bIZUMO1). RT-PCR and Western blot analysis of the bovine tissues indicated that bIZUMO1 was specifically expressed in the testis and sperm, Furthermore, the result of o...

  17. Expression and function analysis of metallothionein in the testis of Portunus trituberculatus exposed to cadmium

    International Nuclear Information System (INIS)

    Xiang, Dong-Fang; Zhu, Jun-Quan; Jin, Shan; Hu, Yan-Jun; Tan, Fu-Qing; Yang, Wan-Xi

    2013-01-01

    Highlights: •We identified P. trituberculatus MT-1 and MT-2 complete cDNA sequence. •We analyzed the protein alignment comparisons and phylogenetic trees of MT-1 and MT-2. •RT-PCR analysis the tissue expression of MT-1 and MT-2 mRNA. •The spatial and temporal distribution pattern of MT-1 and MT-2 mRNA during spermiogenesis. •Testis MT-1 and MT-2 mRNA expression are dramatically affected after the cadmium exposure. -- Abstract: Metallothioneins (MTs) possess a unique molecular structure that provides metal-binding and redox capabilities. These capabilities include the maintenance of metal equilibria that protect against heavy metals (especially cadmium) and oxidative damage. Past studies have focused on the function of MTs in vertebrates. However, the functions of MTs during spermiogenesis in invertebrates remain unclear. In order to investigate the function of MTs during spermiogenesis in Portunus trituberculatus, we used RT-PCR and RACE to identify two MT complete cDNA sequences in the total RNA from the P. trituberculatus testis. The 450 bp MT-1 cDNA consists of a 77 bp 5′ untranslated region, a 196 bp 3′ untranslated region, and a 177 bp open reading frame that encodes 58 amino acids including 19 cysteines. The 581 bp MT-2 cDNA consists of 73 bp 5′ untranslated region, a 328 bp 3′ untranslated region, and a 180 bp open reading frame that encodes 59 amino acids including 18 cysteines. MT-1 and MT-2 of P. trituberculatus more closely resemble invertebrate (especially crab) MT homologues than vertebrate MT homologues as indicated by protein alignment comparisons and phylogenetic tree analysis. MT-1 and MT-2 were detected in the heart, testis, muscle, hepatopancreas, and gill of P. trituberculatus by tissue expression analysis. In addition, MT-1 and MT-2 are present during the entire process of spermiogenesis in P. trituberculatus as indicated by H and E staining and in situ hybridization. MT-1 and MT-2 expression levels significantly increase

  18. Expression and function analysis of metallothionein in the testis of Portunus trituberculatus exposed to cadmium

    Energy Technology Data Exchange (ETDEWEB)

    Xiang, Dong-Fang [School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211 (China); The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058 (China); Zhu, Jun-Quan; Jin, Shan [School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211 (China); Hu, Yan-Jun [Department of Reproductive Endocrinology, Women' s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006 (China); Tan, Fu-Qing [The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003 (China); Yang, Wan-Xi, E-mail: wxyang@spermlab.org [The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058 (China)

    2013-09-15

    Highlights: •We identified P. trituberculatus MT-1 and MT-2 complete cDNA sequence. •We analyzed the protein alignment comparisons and phylogenetic trees of MT-1 and MT-2. •RT-PCR analysis the tissue expression of MT-1 and MT-2 mRNA. •The spatial and temporal distribution pattern of MT-1 and MT-2 mRNA during spermiogenesis. •Testis MT-1 and MT-2 mRNA expression are dramatically affected after the cadmium exposure. -- Abstract: Metallothioneins (MTs) possess a unique molecular structure that provides metal-binding and redox capabilities. These capabilities include the maintenance of metal equilibria that protect against heavy metals (especially cadmium) and oxidative damage. Past studies have focused on the function of MTs in vertebrates. However, the functions of MTs during spermiogenesis in invertebrates remain unclear. In order to investigate the function of MTs during spermiogenesis in Portunus trituberculatus, we used RT-PCR and RACE to identify two MT complete cDNA sequences in the total RNA from the P. trituberculatus testis. The 450 bp MT-1 cDNA consists of a 77 bp 5′ untranslated region, a 196 bp 3′ untranslated region, and a 177 bp open reading frame that encodes 58 amino acids including 19 cysteines. The 581 bp MT-2 cDNA consists of 73 bp 5′ untranslated region, a 328 bp 3′ untranslated region, and a 180 bp open reading frame that encodes 59 amino acids including 18 cysteines. MT-1 and MT-2 of P. trituberculatus more closely resemble invertebrate (especially crab) MT homologues than vertebrate MT homologues as indicated by protein alignment comparisons and phylogenetic tree analysis. MT-1 and MT-2 were detected in the heart, testis, muscle, hepatopancreas, and gill of P. trituberculatus by tissue expression analysis. In addition, MT-1 and MT-2 are present during the entire process of spermiogenesis in P. trituberculatus as indicated by H and E staining and in situ hybridization. MT-1 and MT-2 expression levels significantly increase

  19. Histological evaluation of the human testis--approaches to optimizing the clinical value of the assessment

    DEFF Research Database (Denmark)

    McLachlan, R I; Rajpert-De Meyts, E; Hoei-Hansen, C E

    2007-01-01

    on genotype-phenotype relationships. The rising incidence of testis cancer and carcinoma in situ (CIS), especially in infertile populations, requires that every effort be made for its early detection. We provide a systematic approach to the histological classification of spermatogenic disorders and detection...... within the hypospermatogenesis classification, that helps account for reported success of TESE. We propose a new diagnosis code for testicular biopsies that addresses the needs of ART clinicians and allows data storage and retrieval of value in clinical practice and research....

  20. Malignant peritoneal mesothelioma associated with deep vein thrombosis following radiotherapy for seminoma of the testis

    International Nuclear Information System (INIS)

    Sato, Fuminori; Yamazaki, Hajime; Ataka, Ken; Mashima, Ichiro; Suzuki, Kenta; Takahashi, Toru; Umezu, Hajime; Gejyo, Fumitake

    2000-01-01

    A 52-year-old man developed malignant peritoneal mesothelioma 17 years after radiotherapy for seminoma of the testis. Although asbestos exposure is considered to be the major risk factor for the development of malignant mesothelioma, prior therapeutic radiation has also been postulated as a causative factor. The unexplained appearance of ascites or pleural effusion within a previously irradiated area should be considered suggestive of malignant mesothelioma in any long-term survivor of cancer. In addition, the patient suffered a deep vein thrombosis four years before the diagnosis of mesothelioma. Deep vein thrombosis is a common complication of malignant disease, and is often the first clue to occult malignancy. (author)

  1. Malignant peritoneal mesothelioma associated with deep vein thrombosis following radiotherapy for seminoma of the testis

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Fuminori; Yamazaki, Hajime; Ataka, Ken; Mashima, Ichiro; Suzuki, Kenta; Takahashi, Toru; Umezu, Hajime; Gejyo, Fumitake [Niigata Univ. (Japan). School of Medicine

    2000-11-01

    A 52-year-old man developed malignant peritoneal mesothelioma 17 years after radiotherapy for seminoma of the testis. Although asbestos exposure is considered to be the major risk factor for the development of malignant mesothelioma, prior therapeutic radiation has also been postulated as a causative factor. The unexplained appearance of ascites or pleural effusion within a previously irradiated area should be considered suggestive of malignant mesothelioma in any long-term survivor of cancer. In addition, the patient suffered a deep vein thrombosis four years before the diagnosis of mesothelioma. Deep vein thrombosis is a common complication of malignant disease, and is often the first clue to occult malignancy. (author)

  2. Avances en el diseño de una herramienta de autor para la creación de actividades educativas basadas en realidad aumentada

    Directory of Open Access Journals (Sweden)

    Moralejo, Lucrecia

    2014-04-01

    Full Text Available En este artículo se presentan los avances logrados en el diseño de una herramienta de autor, llamada AuthorAR, orientada a la creación de actividades educativas basadas en realidad aumentada (RA. AuthorAR permite generar actividades de exploración y de estructuración de frases, que pueden favorecer procesos de adquisición del lenguaje y de entrenamiento de la comunicación, por lo que se hará referencia a las posibilidades que ofrece en este sentido. Se presentan aquí: una descripción de esta herramienta de autor, una revisión de antecedentes en la temática y la propuesta de evolución de este proyecto, con los primeros resultados obtenidos y las conclusiones arribadas.

  3. A psicologia histórico-cultural soviética (1917-1991: problemas de paternidade associados a obras e autores importantes

    Directory of Open Access Journals (Sweden)

    Roberto Valdés Puentes

    2017-02-01

    Full Text Available Resumo: Mukhina e Venguer estão envolvidos em problemas de “paternidade”. Chegou-se a conclusão que os livros Temas de psicologia pré-escolar e Psicologia Pré-escolar, publicados por Venguer e Mukhina, respectivamente, são praticamente um único livro devido a seu conteúdo. Em tal sentido, recomenda-se que os autores sejam adequadamente citados, com base na edição específica, acrescida, no segundo caso, da problematização que existe em torno dessas obras e autores, bem como de uma posição que assumidamente reconheça que essas ideias e produções pertencem a dois cientistas diferentes. Palavras-chave: Psicologia Histórico-cultural. Ex-União Soviética. Petrovsky. Mukhina. Venguer.

  4. JClic y Edilim: programas de autor para el diseño de actividades educativas en soporte digital para Educación Infantil y Primaria

    Directory of Open Access Journals (Sweden)

    Raul Tarraga

    2012-12-01

    Full Text Available Este trabajo analiza las prestaciones de JClic y EdiLim, dos programas de autor para el diseño de actividades educativas para las etapas de educación infantil y primaria. Se revisan algunos de los tipos de actividades que pueden diseñarse con cada programa, y se ofrecen datos informativos sobre cómo descargar los programas ylocalizar repositorios de recursos y tutoriales de uso en Internet.

  5. EL AUTOR, ESLABÓN FOSILIZADO: DE LA RENOVACIÓN ESTILÍSTICA DE LA NUEVA OLA DEL CINE FRANCÉS

    Directory of Open Access Journals (Sweden)

    Francisco Montaña Ibáñez

    2011-04-01

    Full Text Available Recurriendo a algunas ideas de Walter Benjamin y del romanticismo, se intenta poner en perspectiva la relación que establece la Nueva Ola de Cine francés, y en particular Francois Truffaut, con la tradición cinematográfica. Luego, se confronta esas ideas con la idea del autor que es central en la mirada de Truffaut sobre la historia.

  6. Conflicto de leyes al interior del régimen común de derechos de autor y derechos conexos de la comunidad andina de naciones

    Directory of Open Access Journals (Sweden)

    Marcela Palacio Puerta

    2013-11-01

    Full Text Available La Comunidad Andina de Naciones (CAN es una integración entre cuatro países latinoamericanos buscando un desarrollo integral especialmente en términos económicos. Como parte de dicha integración, los países miembros determinaron que en materia de propiedad intelectual la legislación sería conjunta. De esta forma, la CAN promulgó el régimen común de derechos de autor y derechos conexos el cual es de aplicación y efecto directo al interior de los países miembros. No obstante, los países miembros de la Comunidad han entrado en diversas negociaciones de Tratados de Libre Comercio (TLC, los cuales requieren al país contratante la implementación de ciertas disposiciones en materia de derechos de autor y derechos conexos, como en el caso de los TLC firmados con Estados Unidos. El problema comienza cuando las disposiciones mandadas a implementar a través de los TLC difieren de aquellas establecidas por la can, requiriendo al país miembro de la Comunidad establecer estándares de protección más altos que los establecidos por la CAN o a regular aspectos sobre los cuales la Comunidad no se ha pronunciado. Este artículo analiza si el bilateralismo llevado a cabo por Estados Unidos en los últimos años en el ámbito de derechos de autor y derechos conexos está generando o generará conflictos de leyes al interior del régimen común de derechos de autor y derechos conexos de la CAN.

  7. Expression and localization of nerve growth factor (NGF in the testis of alpaca (llama pacos

    Directory of Open Access Journals (Sweden)

    Changsheng Dong

    2011-04-01

    Full Text Available During alpaca testis development and spermatogenesis, nerve growth factor (NGF may play an important role. The main aim of this study was to determine the expression and localization of NGF in the alpaca testis, and to discuss the important role of NGF in alpaca reproductive characteristics. Immunohistochemical staining technique and real-time PCR were used. The expression of NGF in the same cells one-month old (newborn alpacas 12-month, and 24-month old alpacas showed significant differences (p < 0.05; 12- and 24-month old alpacas showed no significant differences (p > 0.05; NGF at different cell stages showed no significant differences (p > 0.05. It suggests that NGF may be involved in the regulation of spermatogenesis, which provides direct evidence for NGF action in the alpaca testis during postnatal development and spermatogenesis. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 55–61

  8. Endometrioid like yolk sac tumor of the testis with small teratomatous foci: A case report and review of the literature.

    Science.gov (United States)

    Hazarika, Prabir

    2015-01-01

    I have reported a case of endometrioid like yolk sac tumor of the testis in a 20-year-old boy. Endometrioid like yolk sac tumor is a rare tumor. A few cases have been reported in ovary. In case of male, a case of pure glandular endometrioid like yolk sac tumor is reported in a 43 years male in right undescended testis and another case of abdominal metastasis showing endometrioid pattern from mixed testicular germ cell tumor comprising of teratoma and embryonal carcinoma. My patient was a 20-year-old male presented with painless enlargement of right testis. Grossly the tumor was glistening creamish white with a multicystic appearance. Histopathological examination showed the tumor to be composed of glandular elements resembling early secretory endometrium, foci of keratinized thin squamous epithelium and a single focus of benign cartilage. The glandular elements show immunohistochemical positivity for AFP, cytokeratin 7 (CK7) and epithelial membrane antigen (EMA).

  9. Endometrioid like yolk sac tumor of the testis with small teratomatous foci: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Prabir Hazarika

    2015-01-01

    Full Text Available I have reported a case of endometrioid like yolk sac tumor of the testis in a 20-year-old boy. Endometrioid like yolk sac tumor is a rare tumor. A few cases have been reported in ovary. In case of male, a case of pure glandular endometrioid like yolk sac tumor is reported in a 43 years male in right undescended testis and another case of abdominal metastasis showing endometrioid pattern from mixed testicular germ cell tumor comprising of teratoma and embryonal carcinoma. My patient was a 20-year-old male presented with painless enlargement of right testis. Grossly the tumor was glistening creamish white with a multicystic appearance. Histopathological examination showed the tumor to be composed of glandular elements resembling early secretory endometrium, foci of keratinized thin squamous epithelium and a single focus of benign cartilage. The glandular elements show immunohistochemical positivity for AFP, cytokeratin 7 (CK7 and epithelial membrane antigen (EMA.

  10. Identification of Hedgehog Signaling Outcomes in Mouse Testis Development Using a Hanging Drop-Culture System1

    Science.gov (United States)

    Szczepny, Anette; Hogarth, Cathryn A.; Young, Julia; Loveland, Kate L.

    2008-01-01

    The Hedgehog (Hh) signaling pathway affects fetal testis growth. Recently, we described the dynamic cellular production of Hh signaling pathway components in juvenile and adult rodent testes. The Hh signaling is understood to regulate cord formation in the fetal testis, but minimal knowledge exists regarding how Hh signaling impacts the postnatal testis. To investigate this, we employed hanging drop cultures, which are used routinely in embryoid body formation. This approach has the advantage of using small media volume, and we examined its suitability for short-term culture of both murine embryonic gonads and adult testis tubules. The effects of cyclopamine, a specific Hh signaling inhibitor, were examined following culture of Embryonic Day 11.5 urogenital ridges (as control) and adult seminiferous tubule fragments for 24–48 h using histological, cell proliferation, and gene expression analyses. Cultured embryonic testes displayed generally normal cord structure, anti-Müllerian hormone (Amh) expression, and cell proliferation; known Hh target gene expression (Gli1, osteopontin, official symbol Spp1, and Amh) was altered in response to cyclopamine. Cultured adult tubules exhibited some loss of seminiferous epithelium organization over 48 h. Spermatogonia continued to proliferate, however, and no significant loss of viability was noted overall. Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells. These novel results identify Hh target genes in the testis and demonstrate this signaling pathway likely affects cell survival and differentiation in the context of normal adult testis. PMID:18843087

  11. Emilio Pasquini, ed., Studi e problemi di critica testuale: 1960-2010. Per i 150 anni della Commissione per i testi di lingua

    Directory of Open Access Journals (Sweden)

    Giuseppe Di Stefano

    2016-01-01

    Full Text Available Reseña de Emilio Pasquini, ed., Studi e problemi di critica testuale: 1960-2010. Per i 150 anni della Commissione per i testi di lingua, Commissione per i testi di lingua (Collezione di opere inedite o rare, 169, Bologna, 2012, x + 320 pp. ISBN: 9788898096152.

  12. Emilio Pasquini, ed., Studi e problemi di critica testuale: 1960-2010. Per i 150 anni della Commissione per i testi di lingua

    OpenAIRE

    Di Stefano, Giuseppe

    2016-01-01

    Reseña de Emilio Pasquini, ed., Studi e problemi di critica testuale: 1960-2010. Per i 150 anni della Commissione per i testi di lingua, Commissione per i testi di lingua (Collezione di opere inedite o rare, 169), Bologna, 2012, x + 320 pp. ISBN: 9788898096152.

  13. [Morphological verification problems of Chernobyl factor influence on the testis of coal miners of Donbas-liquidators of Chernobyl accident].

    Science.gov (United States)

    Danylov, Iu V; Motkov, K V; Shevchenko, T I

    2013-01-01

    Problem of a diagnostic of Chernobyl factor influences on different organs and systems of Chernobyl accident liquidators are remain actually until now. Though morbidly background which development at unfavorable work conditions in underground coalminers prevents from objective identification features of Chernobyl factor influences. The qualitative and quantitative histological and immunohistochemical law of morphogenesis changes in testis of Donbas's coalminer - non-liquidators Chernobyl accident in comparison with the group of Donbas's coalminers-liquidators Chernobyl accident, which we were stationed non determined problem. This reason stipulates to development and practical use of mathematical model of morphogenesis of a testis changes.

  14. Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis

    DEFF Research Database (Denmark)

    Kristensen, D G; Nielsen, J E; Jørgensen, Anne

    2014-01-01

    cells were assessed by quantitative measurements. The expression of TET1, TET2, APOBEC1, MBD4, APEX1, PARP1, DNMT1, DNMT3A, DNMT3B and DNMT3L in adult testis specimens with CIS and in human fetal testis was investigated by immunohistochemistry and immunofluorescence.Results:DNA from micro-dissected CIS...... cells contained very low levels of 5hmC produced by ten eleven translocation (TET) enzymes. CIS cells and fetal germ cells expressed the suggested initiator of active demethylation, APOBEC1, and the base excision repair proteins MBD4, APEX1 and PARP1, whereas TETs - the alternative initiators were...

  15. La revista Medicina y Seguridad en el Trabajo y el respeto al derecho de autoría Medicina y Seguridad del Trabajo journal and protecting copyright

    Directory of Open Access Journals (Sweden)

    Jorge Veiga de Cabo

    2012-09-01

    Full Text Available El autor recuerda los principios básicos internacionales que amparan los derechos de autor aprobados por el Convenio de Berna para la Protección de las Obras Literarias y Artística, la Declaración Universal de Derechos Humanos y el Derecho de la Unión Europea del Tratado de Maastricht. Se analizan las circunstancias generales que amparan la autoría, y en particular en el marco de la biomedicina y de las ciencias de la Salud, así como las principales características del mercado editorial y los cambios que se han producido en los últimos años. Se describen los principales factores asociados a la aparición de la iniciativa Open Access y su compromiso con la preservación del Copyright y los derechos de autor. Se presenta la licencia Creative Commons como alternativa eficaz en la gestión de los derechos de autoría. Por último, se declara la adhesión oficial de la revista Medicina y Seguridad del Trabajo a la licencia Creative Commons bajo modalidad Reconocimiento -NoComercial - SinObraDerivada (by-nc-nd.The author reviews the international basic principles of Copyrights approved by the Berne Convention for the Protection of Literary and Artistic Works, the Universal Declaration of Human Rights and the Treaty of Maastricht on the European Union Right. General circumstances to protect Copyrights are analyzed; in particular in Biomedicine and Health Sciences fields, as well as some other specific characteristics related with the publishing market and the main changes suffered in those fields throughout the years. This document describes the relevant factors associated with the emergence of the Open Access initiative and its commitment protecting Copyright. Creative Commons is presented as an effective alternative to preserve Copyrights. Finally, the Medicina y Seguridad del Trabajo journal officially declares its adhesion to Creative Commons under the Attribution-NonCommercial-NoDerivs (by-nc-nd license.

  16. Un análisis inferencialista de la co-autoría de artículos científicos

    Directory of Open Access Journals (Sweden)

    Zamora-Bonilla, Jesús

    2014-12-01

    Full Text Available Co-authorship is very common in most areas of science and has grown as the complexity of research has increased the need for scientific collaboration. But plural authorship tends to complicate the attribution of merit to individual scientists, which is the basis of scientific evaluation. I argue that collaboration does not necessarily entail co-authorship, though in many cases the latter is an option that the individual scientists might not choose, at least in principle: individually authors might separately publish their own contribution to a collaborative project in which they had taken part, or papers could explicitly state what contribution each individual author had made. I ask, hence, why it is that scientists prefer to ‘pool’ their contributions instead of keeping them separate if they are pursuing, amongst other things, individual recognition. My answer, following an inferentialist approach to scientific knowledge, is based on the view of the scientific paper as a piece of argumentation rather than as a piece of knowledge.La co-autoría es muy frecuente en la mayor parte de las áreas científicas. Sin embargo, la autoría plural tiende a complicar la atribución de mérito a cada científico individual (una atribución que es la base de la evaluación científica. En este artículo, argumentamos que la colaboración no implica necesariamente co-autoría: cada autor podría publicar en artículos separados su contribución individual al proyecto colaborativo (o los artículos conjuntos podrían especificar la contribución individual de cada autor. La cuestión que nos planteamos en este artículo es por qué los científicos prefieren fusionar sus contribuciones en lugar de mantenerlas separadas – teniendo en cuenta que su objetivo es, entre otras cosas, el reconocimiento individual –. Nuestra respuesta, enmarcada en una visión inferencialista de la práctica científica, se basa en la idea de que los artículos cient

  17. Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability

    Directory of Open Access Journals (Sweden)

    Aaraby Yoheswaran Nielsen

    2016-06-01

    Full Text Available Genomic instability is a hallmark of human cancer and an enabling factor for the genetic alterations that drive cancer development. The processes involved in genomic instability resemble those of meiosis, where genetic material is interchanged between homologous chromosomes. In most types of human cancer, epigenetic changes, including hypomethylation of gene promoters, lead to the ectopic expression of a large number of proteins normally restricted to the germ cells of the testis. Due to the similarities between meiosis and genomic instability, it has been proposed that activation of meiotic programs may drive genomic instability in cancer cells. Some germ cell proteins with ectopic expression in cancer cells indeed seem to promote genomic instability, while others reduce polyploidy and maintain mitotic fidelity. Furthermore, oncogenic germ cell proteins may indirectly contribute to genomic instability through induction of replication stress, similar to classic oncogenes. Thus, current evidence suggests that testis germ cell proteins are implicated in cancer development by regulating genomic instability during tumorigenesis, and these proteins therefore represent promising targets for novel therapeutic strategies.

  18. Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia

    Directory of Open Access Journals (Sweden)

    Chen Yao

    2016-01-01

    Full Text Available To investigate the effect of pentoxifylline (PTX on spermatogenesis dysfunction induced by intermittent hypobaric hypoxia (IHH and unveil the underlying mechanism, experimental animals were assigned to Control, IHH+Vehicle, and IHH+PTX groups and exposed to 4 cycles of 96 h of hypobaric hypoxia followed by 96 h of normobaric normoxia for 32 days. PTX was administered for 32 days. Blood and tissue samples were collected 7 days thereafter. Serum malondialdehyde levels were used to assess lipid peroxidation; ferric-reducing antioxidant power (FRAP, superoxide dismutase, and catalase and glutathione peroxidase enzyme activities were assessed to determine antioxidant capacity in various samples. Testis histopathology was assessed after hematoxylin-eosin staining by Johnsen’s testicular scoring system. Meanwhile, testosterone synthase and vimentin amounts were assessed by immunohistochemistry. Sperm count, motility, and density were assessed to determine epididymal sperm quality. IHH treatment induced significant pathological changes in testicular tissue and enhanced serum lipid peroxide levels, while reducing serum FRAP, antioxidant enzyme activities, and testosterone synthase expression. Moreover, IHH impaired epididymal sperm quality and vimentin structure in Sertoli cells. Oral administration of PTX improved the pathological changes in the testis. IHH may impair spermatogenesis function of testicular tissues by inducing oxidative stress, but this impairment could be attenuated by administration of PTX.

  19. In vitro maintenance of spermatogenesis in Xenopus laevis testis explants cultured in serum-free media

    International Nuclear Information System (INIS)

    Risley, M.S.; Miller, A.; Bumcrot, D.A.

    1987-01-01

    Spermatogenesis has been maintained for extended periods in Xenopus laevis testis explants cultured in serum-free media supplemented with bovine serum albumin, insulin, transferrin, follicle-stimulating hormone, dihydrotestosterone, testosterone, retinol, ascorbate, and tocopherol. The organization of the testis fragments was maintained for 28 days, and all stages of development were present throughout the culture period. 3 H-Thymidine-labeled secondary (Type B) spermatogonia developed in 28 days into spermatids at the acrosomal vesicle stage whereas labeled zygotene spermatocytes became mature spermatids in 28 days. Spermatogonial proliferation also continued in vitro for 28 days. Germ cell differentiation was not dependent upon exogenous testosterone, ascorbate, or tocopherol since 3 H-labeled spermatogonia became mature spermatids in testes cultured 35 days in media lacking these supplements. Autoradiography demonstrated that 55% of the luminal sperm present in explants cultured 10 days had differentiated in vitro. Sperm from testes cultured 10-35 days were similar to sperm from freshly dissected testes with regard to motility and fecundity, and eggs fertilized with sperm from explant cultures developed normally into swimming tadpoles. The results demonstrate the feasibility of maintaining vertebrate spermatogenesis in culture and suggest that in vitro analysis of Xenopus spermatogenesis using defined media may provide important insights into the evolution of regulatory mechanisms in spermatogenesis

  20. Growing indications for CEUS: The kidney, testis, lymph nodes, thyroid, prostate, and small bowel

    Energy Technology Data Exchange (ETDEWEB)

    Cantisani, V., E-mail: vito.cantisani@uniroma1.it [Department of Radiology, Anatomopathology and Oncology, “Sapienza” University of Rome (Italy); Bertolotto, M. [Department of Radiology, University of Trieste (Italy); Weskott, H.P. [Central Ultrasound Department, Klinikum Siloah , Hannover (Germany); Romanini, L. [University Hospital of Pavia (Italy); Grazhdani, H. [Department of Radiology, Anatomopathology and Oncology, “Sapienza” University of Rome (Italy); Passamonti, M. [Dipartimento di Scienze Radiologiche, Ospedale di Lodi (Italy); Drudi, F.M.; Malpassini, F. [Department of Radiology, Anatomopathology and Oncology, “Sapienza” University of Rome (Italy); Isidori, A. [Department of Experimental Medicine, “Sapienza” University of Rome, Rome (Italy); Meloni, F.M. [Dipartimento servizi diagnostici, Ospedale Valduce, Como (Italy); Calliada, F. [University Hospital of Pavia (Italy); D’Ambrosio, F. [Department of Radiology, Anatomopathology and Oncology, “Sapienza” University of Rome (Italy)

    2015-09-15

    Highlights: • Contrast enhanced ultrasonography (CEUS) is increasingly used for non-hepatic applications. • There is a growing clinical use for a variety of pathologies of the kidney, testis, and small bowel. • Updated knowledge for proper use of CEUS in uncommon fields is provided. - Abstract: Contrast enhanced ultrasonography (CEUS) is increasingly used for non-hepatic applications as well, so that nearly all organs have been investigated. Among them, there is a growing clinical use for a variety of pathologies of the kidney, testis, and small bowel. The possibility to differentiate benign from malignant nodes in cancer patients has been investigated. A new application is in the detection of sentinel nodes after intradermal microbubble injection. The need to distinguish thyroid nodules eligible for fine needle aspiration cytology has led to the use of CEUS in thyroid examinations as well. The potential of CEUS for prostate cancer detection has been extensively investigated, with encouraging initial results. Early promise, however, has not been fulfilled. New perspective regards evaluation of the extent of prostate tissue devascularization following ablative treatments.