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Sample records for test study iii

  1. Antithrombin III blood test

    Science.gov (United States)

    ... medlineplus.gov/ency/article/003661.htm Antithrombin III blood test To use the sharing features on this page, ... a protein that helps control blood clotting. A blood test can determine the amount of AT III present ...

  2. Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study

    NARCIS (Netherlands)

    Mazzone, E.; Bianco, F.; Main, M.; van den Hauwe, M.; Ash, M.; de Vries, R.; Fagoaga Mata, J.; Stein, S.; de Sanctis, R.; D'Amico, A.; Palermo, C.; Fanelli, L.; Scoto, M. C.; Mayhew, A.; Eagle, M.; Vigo, M.; Febrer, A.; Korinthenberg, R.; de Visser, M.; Bushby, K.; Muntoni, F.; Goemans, N.; Sormani, M. P.; Bertini, E.; Pane, M.; Mercuri, E.

    2013-01-01

    The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in

  3. Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study.

    Science.gov (United States)

    Hedberg, Yolanda S; Erfani, Behnaz; Matura, Mihály; Lidén, Carola

    2018-01-11

    Chromium (Cr) is a common skin sensitizer. The use of Cr(VI) in leather is restricted in the EU, but that of Cr(III) is not. To assess whether prolonged exposure to Cr-tanned leather with mainly Cr(III) release may elicit allergic contact dermatitis in Cr-allergic individuals. Ten Cr-allergic subjects and 22 controls were patch tested with serial dilutions of Cr(III) and Cr(VI), and with leather samples. They then conducted a use test with a Cr-tanned and a Cr-free leather bracelet over a period of 3 weeks, for 12 h per day. Cr deposited on the skin from the bracelets was measured in the controls, and the diphenylcarbazide test for Cr(VI) and extraction tests for Cr(III) and Cr(VI) were conducted for the different leathers. Four of 10 Cr-allergic subjects developed positive reactions to the Cr-tanned bracelet within 7-21 days, whereas only 1 of 10 had a positive patch test reaction to this leather. Cr released from the Cr-tanned leather was most probably entirely Cr(III), with a quantifiable amount being deposited on the skin. This study strongly suggests that prolonged and repeated exposure to Cr-tanned leather with mainly Cr(III) release is capable of eliciting allergic contact dermatitis in Cr-allergic individuals. © 2018 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

  4. GALEN skin test study III: Minimum battery of test inhalent allergens needed in epidemiological studies in patients

    NARCIS (Netherlands)

    Bousquet, P.-J.; Burbach, G.; Heinzerling, L. M.; Edenharter, G.; Bachert, C.; Bindslev-Jensen, C.; Bonini, S.; Bousquet-Rouanet, L.; Demoly, P.; Bresciani, M.; Bruno, A.; Gjomarkaj, M.; Canonica, G. W.; Darsow, U.; Durham, S.; Fokkens, W. J.; Giavi, S.; Gramiccioni, C.; Papadopoulos, N. G.; Haahtela, T.; Kowalski, M. L.; Magyar, P.; Muraközi, G.; Orosz, M.; Röhnelt, C.; Stingl, G.; Todo-Bom, A.; von Mutius, E.; Wiesner, A.; Wöhrl, S.; Bousquet, J.; Zuberbier, T.

    2009-01-01

    Background: The number of allergens to be tested in order to identify sensitized patients is important in order to have the most cost-effective approach in epidemiological studies. Objective: To define the minimal number and the type of skin prick test (SPT) allergens required to identify a patient

  5. The Study of Productivity Measurement and Incentive Methodology (Phase III - Paper Test). Volume 1

    Science.gov (United States)

    1986-03-14

    analogy of a crown of jewels might be used to illustrate the relationship. The models tested represent the jewels and are valuable in their own...right. However, when the jewels are placed in the crown (models built into an integrated methodology), they take on added value. Recommendat ions We...8217:hrou!;h product pries changes. The mathematical relationship remains jusc as crue for a whole induscry as for individual

  6. Brazilian Adaptation of the Woodcock-Johnson III Cognitive Tests

    Science.gov (United States)

    Wechsler, Solange Muglia; Nunes, Carlos Sancineto; Schelini, Patricia Waltz; Pasian, Sonia Regina; Homsi, Silvia Vertoni; Moretti, Lucia; Anache, Alexandra Ayach

    2010-01-01

    An adaptation of the standard battery of Woodcock-Johnson III Tests of Cognitive Abilities (WJ-III) for Brazilian children and youth was investigated. The sample was composed of 1094 students (54 percent girls), ages 7-17, living in Sao Paulo state (91 percent). Items from Brazilian school books as well as from the WJ-III Spanish version…

  7. 76 FR 31860 - Anthropomorphic Test Devices; Hybrid III Test Dummy, ES-2re Side Impact Crash Test Dummy

    Science.gov (United States)

    2011-06-02

    ...; Hybrid III Test Dummy, ES-2re Side Impact Crash Test Dummy AGENCY: National Highway Traffic Safety... rule published on June 16, 2008, concerning a 50th percentile adult male side crash test dummy called... qualification tests of several of the crash test dummies, including the Hybrid III and ES-2re test dummies...

  8. MAQARIN natural analogue study: phase III

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, W.R.; Mazurek, M.; Waber, H.N. [Univ. of Berne (Switzerland). Institutes of Geology, Mineralogy and Petrology, Rock-Water Interaction Group (GGWW); Arlinger, J.; Erlandson, A.C.; Hallbeck, L.; Pedersen, K. [Goeteborg Univ. (Sweden). Dept. of General and Marine Microbiology; Boehlmann, W.; Fritz, P.; Geyer, S.; Geyer, W.; Hanschman, G.; Kopinke, F.D.; Poerschmann, J. [Umweltforschungszentrum Leipzig-Halle (Germany); Chambers, A.V.; Haworth, A.; Ilett, D.; Linklater, C.M.; Tweed, C.J. [AEA Technology plc, Harwell (United Kingdom); Chenery, S.R.N.; Kemp, S.J.; Milodowski, A.E.; Pearce, J.M.; Reeder, S.; Rochelle, C.A.; Smith, B.; Wetton, P.D.; Wragg, J. [British Geological Survey, Keyworth (United Kingdom); Clark, I.D. [Univ. of Ottawa (Canada). Dept. of Geology; Hodginson, E.; Hughes, C.R. [Univ. of Manchester (United Kingdom). Dept. of Earth Sciences; Hyslop, E.K. [British Geological Survey, Edinburgh (United Kingdom); Karlsson, F. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Khoury, H.N.; Salameh, E. [Univ. of Jordan, Amman (Jordan); Lagerblad, B. [Cement Inst., Stockholm (Sweden); Longworth, G. [Univ. of Manchester (United Kingdom). Dept. of Geology; Pitty, A.F. [Private consultant, Norwich (United Kingdom); Savage, D. [QuantiSci Ltd, Melton Mowbray (United Kingdom); Smellie, J.A.T. [ed.] [Conterra AB, Uppsala (Sweden)

    1998-12-01

    This report represents the conclusion to Phase III of the Maqarin Natural Analogue Study. The main thrust was to establish the origin and chemistry of the Western Springs hyper alkaline groundwaters (Na/K enriched Ca(OH){sub 2} type) and to study their interaction with rocks of different compositions, as natural analogues to key processes that might occur at an early stage within the `alkali disturbed zone` of cementitious repositories in different host rocks. Whilst earlier studies at Maqarin were very much site-specific and process-oriented, Phase III provided a regional perspective to the geological evolution of the Maqarin region. This was made possible by greater field access which allowed a more systematic structural and geomorphological study of the area. This has resulted in a greater understanding of the age and spatial relationships concerning formation of the cement zones through spontaneous combustion of the Bituminous Marls, and the subsequent formation of high pH groundwaters at the Eastern and Western Springs locations. At the Western Springs locality, hydrochemical and hydrogeological evaluation of new and published data (plus access to unpublished data), together with detailed mineralogical and geochemical studies, helped to clarify the very earliest stage of cement leachate/host rock interaction. The data were used also to test coupled flow/transport codes developed to assess the long-term evolution of a cementitious repository. Additional objectives addressed include: a) rock matrix diffusion, b) the occurrence and chemical controls on zeolite composition, e) the occurrence and chemical controls on clay stability, and d) the role of microbes, organics and colloids in trace element transport. The Maqarin site now provides a consistent picture explaining the origin of the hyperalkaline groundwaters, and is therefore a unique location for the examination of the mechanisms and processes associated with cementitious repositories. Application of these

  9. MAQARIN natural analogue study: phase III

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, W.R.; Mazurek, M.; Waber, H.N. [Univ. of Berne (Switzerland). Institutes of Geology, Mineralogy and Petrology, Rock-Water Interaction Group (GGWW); Arlinger, J.; Erlandson, A.C.; Hallbeck, L.; Pedersen, K. [Goeteborg University (Sweden). Dept. of General and Marine Microbiology; Boehlmann, W.; Fritz, P.; Geyer, S.; Geyer, W.; Hanschman, G.; Kopinke, F.D.; Poerschmann, J. [Umweltforschungszentrum Leipzig-Halle (Germany); Chambers, A.V.; Haworth, A.; Ilett, D.; Linklater, C.M.; Tweed, C.J. [AEA Technology plc, Harwell (United Kingdom); Chenery, S.R.N.; Kemp, S.J.; Milodowski, A.E.; Pearce, J.M.; Reeder, S.; Rochelle, C.A.; Smith, B.; Wetton, P.D.; Wragg, J. [British Geological Survey, Keyworth (United Kingdom); Clark, I.D. [Univ. of Ottawa (Canada). Dept. of Geology; Hodginson, E.; Hughes, C.R. [Univ. of Manchester (United Kingdom). Dept. of Earth Sciences; Hyslop, E.K. [British Geological Survey, Edinburgh (United Kingdom); Karlsson, F. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Khoury, H.N.; Salameh, E. [Univ. of Jordan, Amman (Jordan); Lagerblad, B. [Cement Institute, Stockholm (Sweden); Longworth, G. [Univ. of Manchester (United Kingdom). Dept. of Geology; Pitty, A.F. [Private consultant, Norwich (United Kingdom); Savage, D. [QuantiSci Ltd, Melton Mowbray (United Kingdom); Smellie, J.A.T. [ed.] [Conterra AB, Uppsala (Sweden)

    1998-12-01

    This report represents the conclusion to Phase III of the Maqarin Natural Analogue Study. The main thrust was to establish the origin and chemistry of the Western Springs hyper alkaline groundwaters (Na/K enriched Ca(OH){sub 2} type) and to study their interaction with rocks of different compositions, as natural analogues to key processes that might occur at an early stage within the `alkali disturbed zone` of cementitious repositories in different host rocks. Whilst earlier studies at Maqarin were very much site-specific and process-oriented, Phase III provided a regional perspective to the geological evolution of the Maqarin region. This was made possible by greater field access which allowed a more systematic structural and geomorphological study of the area. This has resulted in a greater understanding of the age and spatial relationships concerning formation of the cement zones through spontaneous combustion of the Bituminous Marls, and the subsequent formation of high pH groundwaters at the Eastern and Western Springs locations. At the Western Springs locality, hydrochemical and hydrogeological evaluation of new and published data (plus access to unpublished data), together with detailed mineralogical and geochemical studies, helped to clarify the very earliest stage of cement leachate/host rock interaction. The data were used also to test coupled flow/transport codes developed to assess the long-term evolution of a cementitious repository. Additional objectives addressed include: a) rock matrix diffusion, b) the occurrence and chemical controls on zeolite composition, e) the occurrence and chemical controls on clay stability, and d) the role of microbes, organics and colloids in trace element transport. The Maqarin site now provides a consistent picture explaining the origin of the hyperalkaline groundwaters, and is therefore a unique location for the examination of the mechanisms and processes associated with cementitious repositories. Application of these

  10. Spectrophotometric and pH-Metric Studies of Ce(III, Dy(III, Gd(III,Yb(III and Pr(III Metal Complexes with Rifampicin

    Directory of Open Access Journals (Sweden)

    A. N. Sonar

    2011-01-01

    Full Text Available The metal-ligand and proton-ligand stability constant of Ce(III, Dy(III, Gd(III,Yb(III and Pr(III metals with substituted heterocyclic drug (Rifampicin were determined at various ionic strength by pH metric titration. NaClO4 was used to maintain ionic strength of solution. The results obtained were extrapolated to the zero ionic strength using an equation with one individual parameter. The thermodynamic stability constant of the complexes were also calculated. The formation of complexes has been studied by Job’s method. The results obtained were of stability constants by pH metric method is confirmed by Job’s method.

  11. Vietnam Head Injury Study Phase III: A 30 Year Post-Injury Follow-Up Study

    National Research Council Canada - National Science Library

    Grafman, Jordan

    2004-01-01

    Implementation of the Vietnam Head Injury Study Phase III (VHIS - PIII) has begun. By November 2003 all study staff had been hired, and underwent subsequent training to administer the battery of tests...

  12. 75 FR 5931 - Anthropomorphic Test Devices; Hybrid III Test Dummy, ES-2re Side Impact Crash Test Dummy

    Science.gov (United States)

    2010-02-05

    ...; Hybrid III Test Dummy, ES-2re Side Impact Crash Test Dummy AGENCY: National Highway Traffic Safety... final rule that had adopted specifications and qualification requirements for a new crash test dummy called the ``ES- 2re'' test dummy. The ES-2re is a 50th percentile adult male side impact crash test...

  13. Design and testing of the Series III AMTEC cell

    Energy Technology Data Exchange (ETDEWEB)

    Mital, R.; Sievers, R.K.

    1999-07-01

    This paper describes the design and testing of the Series III (S3) Alkali Metal Thermal to Electric Converter (AMTEC) cell which is capable of high efficiency (15--25%) and high power density (100--150 W/kg). Compared to the Series 2 cell which is being developed primarily for space power systems, the Series III cell design provides a significantly higher beta{double_prime}-alumina solid electrolyte (BASE) tube packing density around the heat source thereby increasing cell power and minimizing heat loss. The prototype S3 cell will have 96 BASE tubes and is expected to produce about 150 We. In this cell design the BASE tube assemblies are mounted on a cylindrical tube support plate. The BASE tubes are arranged like spokes on a wheel. The inner cylinder, concentric to the tube support plate, is the hot side of the cell and the outer cylinder is the condenser. Since the prototype S3 cell will be the first of its kind, an engineering cell with same dimensions as the prototype but with 24 BASE tubes was built first. The purpose of this cell was to identify and resolve structural, thermal, manufacturing and sodium management issues before launching into the build of a complete 96 BASE tube cell. The engineering cell has been successfully built and tested. The data of the engineering cells have been used to calibrate the SINDA/FLUINT code to predict the prototype cell performance more accurately. The build of the prototype 96 BASE tube cells is now in progress. This paper presents the design and development of the prototype S3 cell. The fabrication and testing of the first S3 engineering cell is discussed next. Based on the test data of the engineering cell, the anticipated thermal performance of the prototype cells predicted by the calibrated SINDA model are also presented.

  14. Misdiagnosis of high-grade vulvar intraepithelial neoplasia (VIN III) as mild cervical intraepithelial neoplasia (CIN I) on Papanicolaou tests.

    Science.gov (United States)

    August, Carey Z; Ganji, Masoud; Froula, Evelyn

    2003-01-01

    Although high-grade vulvar intraepithelial neoplasia (VIN III) is a clinically significant lesion, it can be overlooked because of nonspecific clinical findings and the fact that its cytomorphologic features mimic those of mild cervical intraepithelial neoplasia (CIN I). To determine if there are cytomorphologic features on Papanicolaou tests that can reliably distinguish between VIN III and CIN I. Papanicolaou tests diagnosed as CIN I from patients with biopsy-proven CIN I were compared with Papanicolaou tests diagnosed as CIN I from patients with biopsy-proven VIN III but with no biopsy-proven CIN I. None of the cytomorphologic features evaluated could reliably distinguish CIN I from VIN III. Since the Papanicolaou test cannot be used to distinguish between CIN I and VIN III, the clinician must pay careful attention to the clinical and colposcopic findings. Further research evaluating the use of ancillary studies, such as human papillomavirus typing, may be useful.

  15. Class - III malocclusion: Genetics or environment? A twins study

    OpenAIRE

    Jena A; Duggal R; Mathur V; Parkash H

    2005-01-01

    Etiology of class-III malocclusion is generally believed to be genetic. A wide range of environmental factors have been suggested as contributing factors for the development of class-III malocclusion. Twin study is one of the most effective methods available for investigating genetically determined variables of malocclusion. Discordancy for class-III malocclusion is a frequent finding in dizygotic twins. However, class-III malocclusion discordancy in monozygotic twins is a rare finding. The p...

  16. Model studies for evaluating the neurobehavioral effects of complex hydrocarbon solvents. III. PBPK modeling of white spirit constituents as a tool for integrating animal and human test data

    NARCIS (Netherlands)

    Hissink, A.M.; Krüse, J.; Kulig, B.M.; Verwei, M.; Muijser, H.; Salmon, F.; Leenheers, L.H.; Owen, D.E.; Lammers, J.H.C.M.; Freidig, A.P.; McKee, R.H.

    2007-01-01

    As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were

  17. STUDIES IN THE SEROLOGY OF SYPHILIS : III. EXPLANATION OF THE FORTIFYING EFFECT OF CHOLESTERIN UPON THE ANTIGEN AS USED IN THE WASSERMANN AND FLOCCULATION TESTS.

    Science.gov (United States)

    Eagle, H

    1930-10-31

    colloid. Cholesterin therefore causes a coarsened dispersion of antigen by forming a relatively large nucleus upon which antigen is adsorbed. As shown in the text, the larger the antigen particle the greater is its avidity for reagin per unit surface or mass. Thus, the coarse sol formed by dropping water-into-antigen is about twice as efficient as a finely dispersed antigen-into-water sol of the same concentration. The coarsened dispersion caused by cholesterin completely explains the greater sensitivity of the cholesterinized antigen in complement fixation. The same factor obtains in the flocculation reactions. In addition, the coarsened dispersion acts as a preliminary quasi-aggregation, facilitating by just so much the subsequent formation of visible clumps (or sedimenting aggregates) upon the addition of syphilitic serum; moreover, there is less surface in a coarse sol, with more reagin per unit surface, and correspondingly more efficient flocculation. The foregoing would be of purely academic interest were it not for the following considerations. From several points of view cholesterin is unsatisfactory as a sensitizer for antigen. Its solubility in alcohol is small. Even the 0.6 per cent concentration used in the Kahn test is difficult to keep in solution. Yet, as our experiments show, its sensitizing action increases indefinitely with its concentration. If it were sufficiently soluble, even 3 per cent could be used to advantage, increasing the sensitivity of 1(1/2) per cent antigen for complement fixation some 200 to 400 per cent, instead of about 50 per cent, as does 0.2 per cent cholesterin. Since, as we have shown, the sensitizing action of cholesterin upon antigen is due solely to the coarse dispersion it causes, and since it is quite inert during the actual combination of the lipoid particles with reagin, it can be replaced by any substance with similar physical properties. The problem in hand was therefore to find a water-insoluble substance, very soluble in

  18. Observations on cattle schistosomiasis in the Sudan, a study in comparative medicine. III. Field testing of an irradiated Schistosoma bovis vaccine

    Energy Technology Data Exchange (ETDEWEB)

    Majid, A.A.; Bushera, H.O.; Saad, A.M.; Hussein, M.F.; Taylor, M.G.; Dargie, J.D.; Marshall, T.F.; Nelson, G.S.

    1980-05-29

    Previous work has shown that cattle can acquire a strong resistance to Schistosoma bovis infection following repeated natural exposure. Partial resistance to a laboratory challenge with S. bovis has also been demonstrated in calves after immunization with an irradiated schistosomular or cercarial vaccine. The aim of the present study was to see whether this type of caccine could protect calves under the very different conditions of natural exposure to S. bovis in the field. Thirty 6- to 9-month-old calves were each immunized with 10,000 irradiated S. bovis schistosomula by intramuscular injection and 8 weeks later were released into an enzootic area along with 30 unvaccinated animals. The calves were followed up for 10 months, during which period protection was evidenced by a lower mortality rate, a slower rate of acquisition of infection, and lower fecal egg counts in the vaccinated calves. Necropsy of the survivors showed 60 to 70% reductions in worm and tissue egg counts of the vaccinated calves as compared to those not vaccinated.

  19. Production circulator fabrication and testing for core flow test loop. Final report, Phase III

    Energy Technology Data Exchange (ETDEWEB)

    1981-05-01

    The performance testing of two production helium circulators utilizing gas film lubrication is described. These two centrifugal-type circulators plus an identical circulator prototype will be arranged in series to provide the helium flow requirements for the Core Flow Test Loop which is part of the Gas-Cooled Fast Breeder Reactor Program (GCFR) at the Oak Ridge National Laboratory. This report presents the results of the Phase III performance and supplemental tests, which were carried out by MTI during the period of December 18, 1980 through March 19, 1981. Specific test procedures are outlined and described, as are individual tests for measuring the performance of the circulators. Test data and run descriptions are presented.

  20. Adsorption studies of iron (III) on chitin

    Indian Academy of Sciences (India)

    The effect of anions like chloride, nitrate and sulphate and also of cations like zinc, chromium and copper on the adsorption of iron(III) was determined. The time dependence of fraction of adsorption, , at varying particle sizes and doses of chitin and the intraparticle diffusion rate constants, , of the adsorption process ...

  1. Class - III malocclusion: Genetics or environment? A twins study

    Directory of Open Access Journals (Sweden)

    Jena A

    2005-03-01

    Full Text Available Etiology of class-III malocclusion is generally believed to be genetic. A wide range of environmental factors have been suggested as contributing factors for the development of class-III malocclusion. Twin study is one of the most effective methods available for investigating genetically determined variables of malocclusion. Discordancy for class-III malocclusion is a frequent finding in dizygotic twins. However, class-III malocclusion discordancy in monozygotic twins is a rare finding. The purpose of this study of monozygotic twins is to assess the genetic and environmental components of variation within the cranio-dento-facial complex.

  2. Luminescence studies of Sm(III) and Cm(III) complexes in NaSCN/DHDECMP extraction systems

    CERN Document Server

    Chung, D Y; Kimura, T

    1999-01-01

    Laser-induced fluorescence (LIF) studies of Sm(III) and Cm(III) complexes in the NaSCN/DHDECMP solvent extraction system were carried out. Luminescence lifetimes were measured to determine the number of water molecules coordinated to Sm(III), Tb(III), Dy(III), and Cm(III) in the sodium thiocyanate solution and in the DHDECMP phase. The hydration number of Sm(III), Tb(III), Dy(III), and Cm(III) in the sodium thiocyanate solution decreased linearly with increasing sodium thiocyanate concentration. The hydration numbers of Sm(III), Dy(III), and Cm(III) in the DHDECMP phase decreased with increasing sodium thiocyanate concentration. The water molecules in the inner coordination sphere of Sm(III) and Dy(III) extracted into the DHDECMP were not completely removed at low sodium thiocyanate concentration but decreased with increasing sodium thiocyanate concentration. However, in the case of Cm(III) extracted into the DHDECMP phase from the sodium thiocyanate solution, there was no water in the inner coordination sphe...

  3. Toxicological studies and antimicrobial properties of some Iron(III ...

    African Journals Online (AJOL)

    Two iron(III) complexes of Ciprofloxacin were synthesized by reaction of the ligand with iron(III) chloride hexahydrate in different solutions. The nature of bonding of the ligands and the structure of the isolated metal complexes were elucidated on the basis of their physical and spectroscopic studies. The infrared spectra ...

  4. PREFACE: III All-Russian Scientific and Practical Conference on Innovations in Non-Destructive Testing (SibTest 2015)

    Science.gov (United States)

    2016-01-01

    This issue of the journal is devoted to the research and studies presented at the III All-Russian Scientific and Practical Conference on Innovations in Non-Destructive Testing SibTest. The conference was held in Altai, Russia, on 27-31 July 2015. The conference brought together experts from different countries and organizations who had a great opportunity to share knowledge during oral and poster presentations and to initiate discussions on topics that are of interest to the conference attendees. The conference aimed to discuss innovative methods and the application of advanced technologies in non-destructive testing. The conference also attempted to bring together university, academic and industrial science, to expand the co-operation of scientists from different countries in research and development and the commercialization of innovative technologies in non-destructive testing. The key themes of the conference were: ultrasonic and acoustic testing; electromagnetic and thermal testing; various types of radiation non-destructive testing; passive and active testing techniques. The conference organizers are the Institute of Non-Destructive Testing, Tomsk Polytechnic University, with the assistance of the Russian Society for Non-Destructive Testing and Technical Diagnostics, Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences, National Research Tomsk State University, Moscow State Institute of Radio Engineering, Electronics and Automation.

  5. Response of an Impact Test Apparatus for Fall Protective Headgear Testing Using a Hybrid-III Head/Neck Assembly.

    Science.gov (United States)

    Caccese, V; Ferguson, J; Lloyd, J; Edgecomb, M; Seidi, M; Hajiaghamemar, M

    2016-02-01

    A test method based upon a Hybrid-III head and neck assembly that includes measurement of both linear and angular acceleration is investigated for potential use in impact testing of protective headgear. The test apparatus is based upon a twin wire drop test system modified with the head/neck assembly and associated flyarm components. This study represents a preliminary assessment of the test apparatus for use in the development of protective headgear designed to prevent injury due to falls. By including angular acceleration in the test protocol it becomes possible to assess and intentionally reduce this component of acceleration. Comparisons of standard and reduced durometer necks, various anvils, front, rear, and side drop orientations, and response data on performance of the apparatus are provided. Injury measures summarized for an unprotected drop include maximum linear and angular acceleration, head injury criteria (HIC), rotational injury criteria (RIC), and power rotational head injury criteria (PRHIC). Coefficient of variation for multiple drops ranged from 0.4 to 6.7% for linear acceleration. Angular acceleration recorded in a side drop orientation resulted in highest coefficient of variation of 16.3%. The drop test apparatus results in a reasonably repeatable test method that has potential to be used in studies of headgear designed to reduce head impact injury.

  6. Peabody Picture Vocabulary Test (PPVT-III: Psychometric properties and significance for application

    Directory of Open Access Journals (Sweden)

    Nataša Bucik

    2003-12-01

    Full Text Available The purpose of this article is to present the content, conceptual structure and methodological steps of the latest revision of the Peabody Picture Vocabulary Test (PPVT-III, which is a highly functional and valuable vocabulary test that has been in use since 1959 in different language and cultural surroundings. On the case of the PPVT-III we are presenting the procedure of development and standardization of such vocabulary tests as well as its translation and adaptation from one language and cultural milieu to another. We also note the practical use of the PPVT-III for research purposes. In Slovenian language no vocabulary tests were developed or adapted so far; PPVT-III is presented in this context, too.

  7. An Application of Graphical Approach to Construct Multiple Testing Procedure in a Hypothetical Phase III Design

    Directory of Open Access Journals (Sweden)

    Naitee eTing

    2014-01-01

    Full Text Available Many multiple testing procedures (MTP have been developed in recent years. Among these new procedures, the graphical approach is flexible and easy to communicate with non-statisticians. A hypothetical Phase III clinical trial design is introduced in this manuscript to demonstrate how graphical approach can be applied in clinical product development. In this design, an active comparator is used. It is thought that this test drug under development could potentially be superior to this comparator. For comparison of efficacy, the primary endpoint is well established and widely accepted by regulatory agencies. However, an important secondary endpoint based on Phase II findings looks very promising. The target dose may have a good opportunity to deliver superiority to the comparator. Furthermore, a lower dose is included in case the target dose may demonstrate potential safety concerns. This Phase III study is designed as a non-inferiority trial with two doses, and two endpoints. This manuscript will illustrate how graphical approach is applied to this design in handling multiple testing issues.

  8. Extraction and separation studies of Ga(III, In(III and Tl(III using the neutral organophosphorous extractant, Cyanex-923

    Directory of Open Access Journals (Sweden)

    P. M. DHADKE

    2003-07-01

    Full Text Available The neutral extractant, Cyanes-923 has been used for the extraction and separation of gallium(III, indium(III and thallium(III from acidic solution. These metal ions were found to be quantitatively extracted with Cyanex-923 in toluene in the pH range 4.5–5.5, 5.0–6.5 and 1.5–3.0, respectively, and from the organic phase they can be stripped with 2.0 mol dm-3 HNO3, 3.0 mol dm-3 HNO3 and 3.0 mol dm-3 HCl, respectively. The effect of pH equilibration period, diluents, diverse ions and stripping agents on the extraction of Ga(III, In(III and Tl(III has been studied. The stroichiometry of the extracted species of these metal ions was determined on the basis of the slope analysis method. The reaction proceed by solvation and the probable extracted species found were [MCl3. 3Cyanex-923] [where M = Ga(III or In(III ] and [HTlCl4. 3Cyanex-923]. Based on these results a sequential procedure for the separation of Ga(III, In(III and Tl(III from each other was developed.

  9. Essentials of WJ III[TM] Tests of Achievement Assessment. Essentials of Psychological Assessment Series.

    Science.gov (United States)

    Mather, Nancy; Wendling, Barbara J.; Woodcock, Richard W.

    The widely used Woodcock Johnson (WJ) Test of Achievement has been separated into two distinct tests, Achievement and Cognitive Abilities. This book is designed to help busy mental health professionals acquire the knowledge and skills they need to use the third revision of the WJ Tests of Achievement (WJ III ACH) , including administration,…

  10. Studies on Leber's optic neuropathy III.

    Science.gov (United States)

    Palan, A; Stehouwer, A; Went, L N

    1989-01-01

    Neurological investigations, HLA-typing and viral antibody studies were performed in patients with Leber's optic neuropathy (LON), in individuals at risk to develop the disease, in obligatory (female) carriers of the disease, and compared with controls. The only relevant findings were an excess of minor neurological abnormalities in patients with LON and in some individuals from the at risk group. Occasionally, an association of LON and a multiple sclerosis-like picture was observed.

  11. Synthesis, Characterization of La(III, Nd(III, and Er(III Complexes with Schiff Bases Derived from Benzopyran-4-one and Thier Fluorescence Study

    Directory of Open Access Journals (Sweden)

    Aida L. El-Ansary

    2012-01-01

    Full Text Available The Schiff bases, L1, L2, and L3, are synthesized from the condensation of 5,7-dihydroxy-6-formyl-2-methylbenzopyran-4-one (L with 2-aminopyridine (1, p-phenylenediamine (2, and o-phenylenediamine (3. The prepared Schiff bases react with lanthanum (III, neodymium (III, and erbium (III nitrate to give complexes with stoichiometric ratio (1 : 1 (ligand : metal. The binuclear complexes of Er(III with L3 and the three metal ions with L2 are separated. The complexes have been characterized by elemental analysis, molar conductance, electronic absorption, and infrared, 1H-NMR spectral studies. The presence of hydrated and coordinated water molecules is inferred from thermogravimetric analysis. Thermal degradation studies show that the final product is the metal oxide. The luminescence properties of the Nd(III and Er(III complexes in dimethylformamide (DMF solutions were investigated.

  12. GLASS COMPOSITIONS FOR THE NEPHELINE PHASE III STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Fox, K.; Edwards, T.

    2009-06-29

    A series of 29 test glass compositions were selected for Phase III of the nepheline study using a combination of two approaches. The first approach was based on evaluating the glass composition region allowable by all of the Defense Waste Processing Facility (DWPF) Product Composition Control System (PCCS) models with the exception of the current nepheline discriminator. This approach was taken to determine whether there are glass compositions that, while predicted to crystallize nepheline upon slow cooling, would otherwise be acceptable for processing in the DWPF. The second approach was based on quasicrystalline theory of glass structure, which helped predict compositional regions where nepheline should form. A detailed description of this methodology is forthcoming. The selection strategy outlined here will provide an opportunity to determine experimentally whether the glasses that fail the current nepheline discriminator but pass the newly proposed nepheline discriminator are indeed free of nepheline after slow cooling. If this is the case, these data will serve as a significant step toward reducing conservatism in the current nepheline discriminator. The 29 glass compositions selected for testing address both the PCCS model and quasicrystalline theory approaches in evaluating both a reduction in conservatism for the current nepheline discriminator and possible implementation of the newly proposed discriminator based on glass structural theory. These glasses will be fabricated and characterized in the laboratory, with the results and conclusions described in a technical report.

  13. Separation studies of As(III), Sb(III) and Bi(III) by reversed-phase paper chromatographic technique

    Energy Technology Data Exchange (ETDEWEB)

    Raman, B.; Shinde, V.M.

    1987-07-01

    Reversed-phase paper chromatographic separations of As(III), Sb(III) and Bi(III) have been carried out on Whatman No 1 filter paper impregnated with triphenylphosphine oxide as stationary phase and using organic complexing agents such as sodium acetate, sodium succinate and sodium malonate solutions as active mobile phases. Results for the separation of binary and ternary mixtures are reported and the method has been successfully applied to the separation and detection of these elements present in real samples and at ppm level concentration.

  14. Translation into Greek and initial validity and reliability testing of a modified version of the SCIM III, in both English and Greek, for self-use.

    Science.gov (United States)

    Michailidou, Christina; Marston, Louise; De Souza, Lorraine H

    2016-01-01

    To translate and culturally adapt the Spinal Cord Injury Measure version III (SCIM III) into Greek (GR-SCIM III). To conduct initial testing of psychometric properties of both measures by self-report. Forward-backward translation was conducted to produce the GR-SCIM III. Participants completed the English or Greek versions in 2008-2009. Both versions were examined for multidimensionality, internal consistency and concurrent/criterion validity with the EQ-5D. Forty-five Greek adults with spinal cord injury (SCI) (23 males), mean age 61 (SD17) years; mean time since injury 11 (SD9) years, completed the GR-SCIM III. One hundred and seventy four English-speaking adults with SCI (111 males), mean age 47 (SD12) years; mean time since injury 12 (SD11) years, completed the SCIM III. Unidimensionality was confirmed for both versions. Internal consistency was acceptable (α = 0.78 for both). Validity was strong for the "self-care" subscale (GR-SCIM III ρ = -0.78, SCIM III ρ = -0.75) and moderate for the "mobility" subscale (GR-SCIM III ρ = -0.58, SCIM III ρ = -0.45). This has been the first function scale translated and validated in Greek for people with SCI. Both the GR-SCIM III and SCIM III are reliable for use by self-report. More studies are needed to further examine their psychometric properties and compare with observation or interview. The Greek version of the Spinal Cord Independence Measure version III (SCIM) is valid and reliable for self-report. Further testing is needed to assess psychometric qualities not assessed in the present study. Researchers and therapists in Greece can use a specific measure to assess functional independence in people with Spinal Cord Injury (SCI). Consideration needs to be given to the participants' type of injury, which may affect the results of SCIM III.

  15. English Language Proficiency and Test Performance: An Evaluation of Bilingual Students with the Woodcock-Johnson III Tests of Cognitive Abilities

    Science.gov (United States)

    Sotelo-Dynega, Marlene; Ortiz, Samuel O.; Flanagan, Dawn P.; Chaplin, William F.

    2013-01-01

    In this article, we report the findings of an exploratory empirical study that investigated the relationship between English Language Proficiency (ELP) on performance on the Woodcock-Johnson Tests of Cognitive Abilities-Third Edition (WJ III) when administered in English to bilingual students of varying levels of ELP. Sixty-one second-grade…

  16. Long maximal incremental tests accurately assess aerobic fitness in class II and III obese men.

    Directory of Open Access Journals (Sweden)

    Stefano Lanzi

    Full Text Available This study aimed to compare two different maximal incremental tests with different time durations [a maximal incremental ramp test with a short time duration (8-12 min (STest and a maximal incremental test with a longer time duration (20-25 min (LTest] to investigate whether an LTest accurately assesses aerobic fitness in class II and III obese men. Twenty obese men (BMI≥35 kg.m-2 without secondary pathologies (mean±SE; 36.7±1.9 yr; 41.8±0.7 kg*m-2 completed an STest (warm-up: 40 W; increment: 20 W*min-1 and an LTest [warm-up: 20% of the peak power output (PPO reached during the STest; increment: 10% PPO every 5 min until 70% PPO was reached or until the respiratory exchange ratio reached 1.0, followed by 15 W.min-1 until exhaustion] on a cycle-ergometer to assess the peak oxygen uptake [Formula: see text] and peak heart rate (HRpeak of each test. There were no significant differences in [Formula: see text] (STest: 3.1±0.1 L*min-1; LTest: 3.0±0.1 L*min-1 and HRpeak (STest: 174±4 bpm; LTest: 173±4 bpm between the two tests. Bland-Altman plot analyses showed good agreement and Pearson product-moment and intra-class correlation coefficients showed a strong correlation between [Formula: see text] (r=0.81 for both; p≤0.001 and HRpeak (r=0.95 for both; p≤0.001 during both tests. [Formula: see text] and HRpeak assessments were not compromised by test duration in class II and III obese men. Therefore, we suggest that the LTest is a feasible test that accurately assesses aerobic fitness and may allow for the exercise intensity prescription and individualization that will lead to improved therapeutic approaches in treating obesity and severe obesity.

  17. Spectral study of the complexation of Nd (III) with glutathione ...

    Indian Academy of Sciences (India)

    Studies on the difference in energy parameters and comparative absorption spectrophotometry involving 4-4 transitions on Nd(III) and glutathione reduced (GSH) in the absence and presence of Zn(II) have been carried out in aquated organic solvents (50 : 50) like methanol, dioxane, acetonitrile and dimethylformamide.

  18. Division I Hockey Players Generate More Power Than Division III Players During on- and Off-Ice Performance Tests.

    Science.gov (United States)

    Peterson, Ben J; Fitzgerald, John S; Dietz, Calvin C; Ziegler, Kevin S; Ingraham, Stacy J; Baker, Sarah E; Snyder, Eric M

    2015-05-01

    Current research has found anthropometric and physiological characteristics of hockey players that are correlated to performance. These characteristics, however, have never been examined to see whether significant differences exist between on- and off-ice performance markers at different levels of play; Division I, Elite Junior, and Division III. The purpose of this study was to examine the differences that may exist between these characteristics in Division I (24), Elite Junior (10), and Division III hockey (11) players. Forty-five (age: 18-24 years) hockey players completed anthropometric, on-ice, and off-ice tests to ascertain average measures for each division of play. On-ice testing was conducted in full hockey gear and consisted of acceleration, top-speed, and on-ice repeated shift test (RST). Off-ice tests included vertical jump, Wingate, grip strength, and a graded exercise test performed on a skating treadmill to ascertain their (Equation is included in full-text article.). Division I players had significantly lower body fat than their Division III peers (p = 0.004). Division I players also scored significantly better on measures of anaerobic power; vertical jump (p = 0.001), Wingate peak power (p = 0.05), grip strength (p = 0.008), top speed (p = 0.001), and fastest RST course time (p = 0.001) than their Division III counterparts. There was no significant difference between Division I and Elite Junior players for any on- or off-ice performance variable. The results of this study indicate that performance differences between Division I and Division III hockey players seem to be primarily because of the rate of force production.

  19. Experimental results from the sounding vehicle Sonda III test campaign in the Pilot Transonic Wind Tunnel

    Directory of Open Access Journals (Sweden)

    João Batista P. Falcão Filho

    2011-09-01

    Full Text Available The Pilot Transonic Wind Tunnel of the Institute of Aeronautics and Space has conducted the first test campaign of a sounding vehicle, Sonda III. The campaign is part of a project whose activities and final results are presented in this paper. During the test campaign, many activities were performed to increase the productivity and accuracy of the tunnel. These activities included calibration procedures, corrective and preventive trials, development of auxiliary devices, and theoretical and experimental analysis. Two tasks are described in details: the development and tests performed with the static pressure probe and the automatic re-entry flap actuation system. Several tests were carried out with the Sonda III at Mach numbers ranging from 0.3 to 1.0, at stagnation pressures of 70, 94, and 110 kPa. Experimental results include global aerodynamic coefficients (using internal balance and pressure distribution over essential regions of the test article (using pressure sensitive paint technique.

  20. Synthesis, spectroscopic and antimicrobial studies of La(III), Ce(III), Sm(III) and Y(III) Metformin HCl chelates.

    Science.gov (United States)

    Refat, Moamen S; Al-Azab, Fathi M; Al-Maydama, Hussein M A; Amin, Ragab R; Jamil, Yasmin M S; Kobeasy, Mohamed I

    2015-05-05

    Metal complexes of Metformin hydrochloride were prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes were discussed and synthesized to serve as potential insulin-mimetic. Some physical properties and analytical data of the four complexes were checked. The elemental analysis shows that La(III), Ce(III) Sm(III) and Y(III) formed complexes with Metformin in 1:3 (metal:MF) molar ratio. All the synthesized complexes are white and possess high melting points. These complexes are soluble in dimethylsulfoxide and dimethylformamide, partially soluble in hot methanol and insoluble in water and some other organic solvents. From the spectroscopic (infrared, UV-vis and florescence), effective magnetic moment and elemental analyses data, the formula structures are suggested. The results obtained suggested that Metformin reacted with metal ions as a bidentate ligand through its two imino groups. The molar conductance measurements proved that the Metformin complexes are slightly electrolytic in nature. The kinetic thermodynamic parameters such as: E(∗), ΔH(∗), ΔS(∗) and ΔG(∗) were estimated from the DTG curves. The antibacterial evaluations of the Metformin and their complexes were also performed against some gram positive, negative bacteria as well as fungi. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. [Detection of carriers of hemophilia A by testing for HindIII polymorphism in the factor VIII gene by PCR].

    Science.gov (United States)

    Surin, V L; Aseev, M V; Zhukova, E L; Baranov, V S; Solov'ev, G Ia; Grineva, N I; Andreeva, T A; Izhevskaia, V L; Likhacheva, E A; Pliushch, O P

    1990-10-01

    Representatives of 62 families from Moscow and Leningrad with haemophilia A observed in the pedigree were tested for HindIII polymorphism in the factor VIII gene. The proposed scheme of investigation was based on intron 19 of the FVIII gene amplification by the PCR technique followed by restriction analysis with the inner control of hydrolysis. 207 unrelated X-chromosomes were analysed, the frequency of the incidence of the polymorphic HindIII site in the given population found to be 0.29. The frequency of incidence of the HindIII heterozygotes calculated according to Hardy-Weinberg equation was 0.41. This value evidences for relatively high informativity of this polymorphism for carrier detection and prenatal diagnosis of haemophilia A. 23 families (37%) out of 62 examined in the study were informative for this criteria. The new scheme proved to be effective in testing HindIII polymorphism for haemophilia A carrier detection and prenatal diagnosis. The whole procedure takes one day, the radiolabelled probes are not used. The scheme described was inculcated in the All-Union Research Center for Haematology, Ministry of Health, USSR, Moscow, Research Institute for Obstetrics and Gynecology, Leningrad, Institute of Medical Genetics, Greifswald, DDR.

  2. A Modified Edge Crack Torsion Test for Measurement of Mode III Fracture Toughness of Laminated Tape Composites

    Science.gov (United States)

    Czabaj, Michael W.; Davidson, Barry D.; Ratcliffe, James G.

    2016-01-01

    Modifications to the edge crack torsion (ECT) test are studied to improve the reliability of this test for measuring the mode-III fracture toughness, G (sub IIIc), of laminated tape fiber-reinforced polymeric (FRP) composites. First, the data reduction methods currently used in the ECT test are evaluated and deficiencies in their accuracy are discussed. An alternative data reduction technique, which uses a polynomial form to represent ECT specimen compliance solution, is evaluated and compared to FEA (finite element analysis) results. Second, seven batches of ECT specimens are tested, each batch containing specimens with a preimplanted midplane edge delamination and midplane plies with orientations of plus theta divided by minus theta, with theta ranging from 0 degrees to 90 degrees in 15-degree increments. Tests on these specimens show that intralaminar cracking occurs in specimens from all batches except for which theta = 15 degrees and 30 degrees. Tests on specimens of these two batches are shown to result in mode-III delamination growth at the intended ply interface. The findings from this study are encouraging steps towards the use of the ECT test as a standardized method for measuring G (sub IIIc), although further modification to the data reduction method is required to make it suitable for use as part of a standardized test method.

  3. Evaluation of candidate magnetohydrodynamic materials for the U-02 Phase III test

    Energy Technology Data Exchange (ETDEWEB)

    Marchant, D.D.; Bates, J.L.

    1978-06-01

    As part of a cooperative U.S.--U.S.S.R. program, electrode and insulator materials tested at the Westinghouse Electrode Systems Test Facility in Pittsburgh, Pennsylvania, were evaluated. From this evaluation materials will be selected for use in the third phase of tests being conducted in the U-02 magnetohydrodynamics test facility in the Soviet Union. Electrode and insulator materials were examined with both an optical microscope and a scanning electron microscope. The cathodes were found to behave differently from the anodes; most notably, the cathodes showed greater potassium interaction. The lanthanum chromite-based electrodes (excluding those fabricated by plasma-spraying) are recommended for testing in the U-02 Phase III test. Hotpressed, fused-grained MgO and sintered MgAl/sub 2/O/sub 4/ are recommended as insulator materials. The electrode attachment techniques used in the Westinghouse Tests were inadequate and need to be modified for the U-02 test.

  4. Correlations of scores on the Gifted Evaluation Scale with those on WISC-III and Kaufman Brief Intelligence Test for students referred for Gifted Evaluation.

    Science.gov (United States)

    Levinson, E M; Folino, L

    1994-04-01

    29 students (M age of 8.0 yr.) who were referred for evaluation were administered the Gifted Evaluation Scale, the Kaufman Brief Intelligence Test, and the WISC-III. Paired t tests comparing the mean GES Quotient with the K-BIT mean IQ and WISC-III Verbal, Performance, and Full Scale IQs yielded no statistically significant differences (range of IQs = 120.6 to 122.9). While the significant correlation of the GES Quotient and WISC-III Performance IQ was .42, r = -.37 for the GES Quotient and WISC-III Verbal IQ. No significant correlation was found between the GES Quotient and the WISC-III Full Scale or K-BIT IQs. The limitations and implications of the study, with regard to the use of the Gifted Evaluation Scale, are discussed.

  5. Reliability of a Shuttle Run Test for Children with Cerebral Palsy Who Are Classified at Gross Motor Function Classification System Level III

    Science.gov (United States)

    Verschuren, Olaf; Bosma, Liesbeth; Takken, Tim

    2011-01-01

    For children and adolescents with cerebral palsy (CP) classified as Gross Motor Function Classification System (GMFCS) level III there is no running-based field test available to assess their cardiorespiratory fitness. The current study investigated whether a shuttle run test can be reliably (test-retest) performed in a group of children with…

  6. Biomechanical behavior of brain injury caused by sticks using finite element model and Hybrid-III testing.

    Science.gov (United States)

    Li, Kui; Wang, Jiawen; Liu, Shengxiong; Su, Sen; Feng, Chenjian; Fan, Xiaoxiang; Yin, Zhiyong

    2015-01-01

    To study the biomechanical mechanism of head injuries beaten with sticks, which is common in the battery or assaultive cases. In this study, the Hybrid-III anthropomorphic test device and finite element model (FEM) of the total human model for safety (THUMS) head were used to determine the biomechanical response of head while being beaten with different sticks. Total eight Hybrid-III tests and four finite element simulations were conducted. The contact force, resultant acceleration of head center of gravity, intracranial pressure and von Mises stress were calculated to determine the different biomechanical behavior of head with beaten by different sticks. In Hybrid-III tests, the stick in each group demonstrated the similar kinematic behavior under the same loading condition. The peak values of the resultant acceleration for thick iron stick group, thin iron stick group, thick wooden stick group and thin wooden stick group were 203.4 g, 221.1 g, 170.5 g and 122.2 g respectively. In finite element simulations, positive intracranial pressure was initially observed in the frontal comparing with negative intracranial pressure in the contra-coup site. Subsequently the intracranial pressure in the coup site was decreasing toward negative value while the contra-coup intracranial pressure increasing toward positive values. The results illustrated that the stiffer and larger the stick was, the higher the von Mises stress, contact force and intracranial pressure were. We believed that the results in the Hybrid-III tests and THUMS head simulations for brain injury beaten with sticks could be reliable and useful for better understanding the injury mechanism.

  7. Air flow test of MK-III dump heat exchanger tube arrays for JOYO

    Energy Technology Data Exchange (ETDEWEB)

    Isozaki, Kazunori; Kawahara, Hirotaka; Tomita, Naoki [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1997-07-01

    The reactor thermal power of JOYO MK-III is to be increased from 100MWt to 140MWt due to high performance of reactor core. So, Dump Heat Exchanger(DHX) of MK-III was designed to improve its heat removal capability by changing U type heat transport tube arrays to {Sigma} type tube arrays and increasing air flow. Natural frequency between support and support of MK-III DHX`s tube arrays was about 15Hz, and Karman vortex shedding frequency of tube arrays was about 90Hz by Y.N.Chen`s report. Then, a possibility of piling up of Karman vortex shedding frequency in high frequency mode was to be considered. And, air velocity of flow tube arrays is also increased compared to the MK-II DHX. Sodium leak accident of MONJU was caused by a flow-induced vibration of thermometer well. Therefore, the air flow test to tube arrays of MK-III DHX was conducted. High cycles fatigue damage of tube arrays was evaluated. Since, peak stress is below 2kg/mm{sup 2}, it can be said that high cycles fatigue damage of tube arrays by Karman vortex shedding vibration will not be caused. (J.P.N.)

  8. Development and testing of commercial-scale, coal-fired combustion systems: Phase III. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Based on studies that indicated a large potential for significantly increased coal-firing in the commercial sector, the U.S. Department of Energy`s Pittsburgh Energy Technology Center (PETC) sponsored a multi-phase development effort for advanced coal combustion systems. This Final Report presents the results of the last phase (Phase III) of a project for the development of an advanced coal-fired system for the commercial sector of the economy. The project performance goals for the system included dual-fuel capability (i.e., coal as primary fuel and natural gas as secondary fuel), combustion efficiency exceeding 99 percent, thermal efficiency greater than 80 percent, turndown of at least 3:1, dust-free and semi-automatic dry ash removal, fully automatic start-up with system purge and ignition verification, emissions performance exceeding New Source Performance Standards (NSPS) and approaching those produced by oil-fired, Commercial-sized units, and reliability, safety, operability, maintainability, and service life comparable to oil-fired units. The program also involved a site demonstration at a large facility owned by Striegel Supply Company, a portion of which was leased to MTCI. The site, mostly warehouse space, was completely unheated and the advanced coal-fired combustion system was designed and sized to heat this space. Three different coals were used in the project, one low and one high sulfur pulverized Pittsburgh No. 8 coal, and a micronized low volatile, bituminous coal. The sorbents used were Pfizer dolomitic limestone and an Anvil lime. More than 100 hours of screening test`s were performed to characterize the system. The parameters examined included coal firing rate, excess air level, ash recycle rate, coal type, dolomitic limestone feed rate, and steam injection rate. These tests indicated that some additional modifications for coal burning in the system were required.

  9. The Nature of the intermediates in the reactions of Fe(III)- and Mn(III)-microperoxidase-8 with H2O2 : a rapid kinetic study

    NARCIS (Netherlands)

    Primus, J.L.; Grunenwald, S.; Hagedoorn, P.L.; Albrecht-Gary, A.M.; Mandon, D.; Veeger, C.

    2002-01-01

    Kinetic studies were performed with microperoxidase-8 (Fe(III)MP-8), the proteolytic breakdown product of horse heart cytochrome c containing an octapeptide linked to an iron protoporphyrin IX. Mn(III) was substituted for Fe(III) in Mn(III)MP-8.The mechanism of formation of the reactive metal-oxo

  10. Off-season training habits and preseason functional test measures of division iii collegiate athletes: a descriptive report.

    Science.gov (United States)

    Brumitt, Jason; Heiderscheit, Bryan C; Manske, Robert C; Niemuth, Paul E; Rauh, Mitchell J

    2014-08-01

    Division III (D III) collegiate coaches are challenged to assess athletic readiness and condition their athletes during the preseason. However, there are few reports on off-season training habits and normative data of functional assessment tests among D III athletes. The purpose of this study was to examine off-season training habits of D III athletes and their relationships to the standing long jump (SLJ) and single-leg hop (SLH) tests. One-hundred and ninety-three athletes (110 females, age 19.1 ± 1.1 y; 83 males, age 19.5 ± 1.3 y) were tested prior to the start of their sports seasons. Athletes reported their off-season training habits (weightlifting, cardiovascular exercise, plyometric exercise, and scrimmage) during the six weeks prior to the preseason. Athletes also performed three maximal effort SLJs and three SLHs. Male athletes reported training more hours per exercise category than their female counterparts. Mean SLJ distances (normalized to height) were 0.79 ± 0.10 for females and 0.94 ± 0.12 for males. Mean SLH distances for female athletes' right and left limbs were 0.66 (± 0.10) and 0.65 (± 0.10), respectively. Mean SLH distances for male athletes' right and left limbs were 0.75 (± 0.13) and 0.75 (± 0.12), respectively. Several significant differences between off-season training habits and functional test measures were found for both sexes: males [SLJ and weightlifting (p = 0.04); SLH and weightlifting (p = 0.04), plyometrics (p = 0.05)]; females [SLJ and plyometrics (p = 0.04); SLH and scrimmage (p = 0.02)]. This study provides normative data for off-season training habits and preseason functional test measures in a D III athlete population. Greater SLJ and SLH measures were associated with increased time during off-season training. The findings between functional tests and off-season training activities may be useful for sports medicine professionals and strength coaches when designing their preseason training programs. 4.

  11. Synthesis and Structural Studies of Cr(III, Mn(II and Fe(III Complexes of N(2-Benzimidazolylacetylacetohydrazone

    Directory of Open Access Journals (Sweden)

    G. H. Anuradha

    2011-01-01

    Full Text Available The ligand N(2-benzimidazolylacetylacetohydrazone (BAAH have been synthesized and characterized. Coordination complexes of Cr(III, Mn(II and Fe(III have been synthesized with the ligand BAAH. These complexes were characterized on the basis of analytical, conductance, thermal, magnetic data and infrared and electronic spectral data. The ligand BAAH is behaving as a neutral tridentate NNO donar employing two azomethine nitrogens (ring and side chain and carbonyl oxygen. The ligand and it's metal complexes were tested for anti microbial activity on the gram positive S. Aureus, E. coli and Proteus.

  12. DOE ETV-1 electric test vehicle. Phase III: performance testing and system evaluation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, D. W.

    1981-12-01

    The DOE ETV-1 represents the most advanced electric vehicle in operation today. Engineering tests have been conducted by the Jet Propulsion Laboratory in order to characterize its overall system performance and component efficiencies within the system environment. A dynamometer was used in order to minimize the ambient effects and large uncertainties present in track testing. Extensive test requirements have been defined and procedures were carefully controlled in order to maintain a high degree of credibility. Limited track testing was performed in order to corroborate the dynamometer results. Test results include an energy flow analysis through the major subsystems and incorporate and aerodynamic and rolling losses under cyclic and various steady speed conditions. A complete summary of the major output from all relevant dynamometer and track tests is also included as an appendix.

  13. Investigation of Biowaivers for Immediate Release Formulations Containing BCS III Drugs, Acyclovir, Atenolol, and Ciprofloxacin Hydrochloride, Using Dissolution Testing.

    Science.gov (United States)

    Reddy, Nallagundla H S; Patnala, Srinivas; Kanfer, Isadore

    2017-02-01

    The dissolution of several products containing Biopharmaceutical Classification System (BCS) class III drugs, acyclovir, atenolol, and ciprofloxacin hydrochloride, listed in the WHO essential drug list (EDL), was tested and compared with their respective comparator pharmaceutical products (CPPs) marketed in South Africa and India. US Pharmacopeia (USP) buffers of pH 1.2, 4.5, and 6.8 were used as dissolution media and tested using USP apparatus 2 at 75 rpm and 900 ml. Nine acyclovir products were tested, and only three dissolved very rapidly in all media; i.e., they showed a release of >85% in 15 min. Eight atenolol products tested were all very rapidly dissolving in all three pH media. Ten ciprofloxacin hydrochloride products were tested, and the results showed that only five products met the WHO biowaiver criteria. This study indicates that not all marketed products containing the same BCS III active pharmaceutical ingredient (API) in similar strength and dosage form are necessarily in vitro equivalent as per the WHO biowaiver criteria. Furthermore, selection and availability of an innovator product as CPP are important considerations that can affect the outcomes of such studies.

  14. Comparative studies of neodymium (III)-selective PVC membrane sensors

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Vinod K., E-mail: vinodfcy@iitr.ernet.in [Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667 (India); Goyal, Rajendra N.; Sharma, Ram A. [Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667 (India)

    2009-08-04

    Sensors based on two neutral ionophores, N,N'-bis((1H-pyrrol-2-yl)methylene)cyclohexane-1,2-diamine (L{sub 1}) and 3,3'-(cyclohexane-1,2-diylbis(azan-1-yl-1-ylidene) bis(methan-1-yl-1-ylidene)bis(5-hydroxymethyl)pyridine-2-ol) (L{sub 2}) are described for quantification of neodymium (III). Effect of various plasticizers; 2-nitrophenyloctylether (o-NPOE), dibutyl butylphosphonate (DBBP), tri-n-butyl phosphates (TBP), dioctylpthalate (DOP) and chloronapthalen (CN) and anion excluder, sodiumtetraphenylborate (NaTPB) has been studied. The membrane composition of PVC:o-NPOE:ionophore (L{sub 1}):NaTPB (w/w; mg) of 150:300:5:5 exhibited best performance. The sensor with ionophore (L{sub 1}) exhibits significantly enhanced selectivity towards neodymium (III) in the concentration range 5.0 x 10{sup -7} to 1.0 x 10{sup -2} M with a detection limit of 1.0 x 10{sup -7} M and a Nernstian compliance (19.8 {+-} 0.3 mV decade{sup -1} of activity) within pH range 4.0-8.0. The response time of sensor was found as 10 s. The influence of the membrane composition and possible interfering ions has also been investigated on the response properties of the electrode. The fast and stable response, good reproducibility and long-term stability of the sensor are observed. The sensor has been found to work satisfactorily in partially non-aqueous media up to 20% (v/v) content of methanol, ethanol or acetonitrile and could be used for a period of 3 months. The selectivity coefficients determined by using fixed interference method (FIM) indicate high selectivity for neodymium. The proposed electrode shows fairly good discrimination of neodymium (III) from other cations. The application of prepared sensor has been demonstrated in the determination of neodymium (III) in spiked water samples.

  15. The Effect of Grade Norms in College Students: Using the Woodcock-Johnson III Tests of Achievement

    Science.gov (United States)

    Cressman, Markus N.; Liljequist, Laura

    2014-01-01

    The "Woodcock-Johnson III" Tests of Achievement grade norms versus age norms were examined in the calculation of discrepancy scores in 202 college students. Difference scores were calculated between the "Wechsler Adult Intelligence Scale-3rd Edition" Full Scale IQ and the "Woodcock-Johnson III" Total Achievement,…

  16. Exploring the Incorporation of Executive Functions in Intelligence Testing: Factor Analysis of the WAIS-III and Traditional Tasks of Executive Functioning

    NARCIS (Netherlands)

    Aken, L. van; Kessels, R.P.C.; Wingbermühle, P.A.M.; Wiltink, M.; Heijden, P.T. van der; Egger, J.I.M.

    2014-01-01

    The aim of this study was to examine the relationship between subtests of the Wechsler Adult Intelligence Scale – third edition (WAIS-III) and executive functions. The Behavioural Assessment of the Dysexecutive Syndrome, Wisconsin Card Sorting Test, and Stroop Color-Word Test were administered to a

  17. A multi-institutional study of outcomes in stage I-III uterine carcinosarcoma.

    Science.gov (United States)

    Dickson, Elizabeth L; Vogel, Rachel Isaksson; Gehrig, Paola A; Pierce, Stuart; Havrilesky, Laura; Secord, Angeles Alvarez; Dottino, Joseph; Fader, Amanda N; Ricci, Stephanie; Geller, Melissa A

    2015-11-01

    To evaluate the use of adjuvant therapy after primary surgery for stage I-III uterine carcinosarcoma (CS). A multi-institutional retrospective study of women with stage I-III CS was conducted. Analyses were stratified by stage (I/II and III). Patients were categorized according to adjuvant therapy: observation (OBS), radiation (RT), chemotherapy (CT) or multimodal therapy (CT+RT). Overall survival (OS) and progression-free survival (PFS) were analyzed using log-rank tests and Cox proportional hazards models. 303 patients were identified across four institutions: 195 with stage I/II and 108 with stage III disease. In stage I/II disease, 75 (39.9%) received OBS, 33 (17.6%) CT, 37 (19.7%) RT, and 43 (22.9%) CT+RT. OBS was associated with a fourfold increased risk of death compared to CT (adjusted hazard ratio (aHR)=4.48, p=0.003). Patients receiving CT+RT had significantly improved PFS compared to those receiving CT alone (aHR=0.43, p=0.04), but no difference in OS. In the stage III cohort, 16 (15.0%) received OBS, 34 (31.8%) CT, 20 (18.7%) RT, and 37 (34.6%) CT+RT. OBS was associated with worse OS and PFS compared to CT (OS: aHR=2.46, p=0.04; PFS: aHR=2.39, p=0.03, respectively). A potential improvement in PFS was seen for those treated with CT+RT compared to CT alone, however it was not statistically significant (aHR=0.53, p=0.09). Observation after surgery was associated with poor outcomes in uterine CS compared to CT and RT alone. Multimodality therapy for women with stage I/II disease was associated with improved PFS compared to chemotherapy alone. Novel treatment options are needed to improve outcomes in this aggressive disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. A multi-institutional study of outcomes in stage I–III uterine carcinosarcoma

    Science.gov (United States)

    Dickson, Elizabeth L.; Vogel, Rachel Isaksson; Gehrig, Paola A.; Pierce, Stuart; Havrilesky, Laura; Secord, Angeles Alvarez; Dottino, Joseph; Fader, Amanda N.; Ricci, Stephanie; Geller, Melissa A.

    2016-01-01

    Objective To evaluate the use of adjuvant therapy after primary surgery for stage I–III uterine carcinosarcoma (CS). Methods A multi-institutional retrospective study of women with stage I–III CS was conducted. Analyses were stratified by stage (I/II and III). Patients were categorized according to adjuvant therapy: observation (OBS), radiation (RT), chemotherapy (CT) or multimodal therapy (CT + RT). Overall survival (OS) and progression-free survival (PFS) were analyzed using log-rank tests and Cox proportional hazards models. Results 303 patients were identified across four institutions: 195 with stage I/II and 108 with stage III disease. In stage I/II disease, 75 (39.9%) received OBS, 33 (17.6%) CT, 37 (19.7%) RT, and 43 (22.9%) CT + RT. OBS was associated with a fourfold increased risk of death compared to CT (adjusted hazard ratio (aHR) = 4.48, p = 0.003). Patients receiving CT + RT had significantly improved PFS compared to those receiving CT alone (aHR = 0.43, p = 0.04), but no difference in OS. In the stage III cohort, 16 (15.0%) received OBS, 34 (31.8%) CT, 20 (18.7%) RT, and 37 (34.6%) CT + RT. OBS was associated with worse OS and PFS compared to CT (OS: aHR = 2.46, p = 0.04; PFS: aHR = 2.39, p = 0.03, respectively). A potential improvement in PFS was seen for those treated with CT + RT compared to CT alone, however it was not statistically significant (aHR = 0.53, p = 0.09). Conclusions Observation after surgery was associated with poor outcomes in uterine CS compared to CT and RT alone. Multimodality therapy for women with stage I/II disease was associated with improved PFS compared to chemotherapy alone. Novel treatment options are needed to improve outcomes in this aggressive disease. PMID:26348313

  19. The evaluation of MiL-Lx and Hybrid III Leg using Hybrid III and EUROSID2-re Anthropomorphic Test Devices

    CSIR Research Space (South Africa)

    Pandelani, T

    2012-09-01

    Full Text Available the HIII and MiL-Lx instrumented lower legs as loaded by the Modified Lower Limb Impactor (MLLI). Keywords? MiL-Lx;STANAG 4569;AEP 55 Volume 3;EuroSID 2- re;Hybrid III INTRODUCTION Most military research and procurement organizations utilize standard... test methodologies for evaluating the protection level of military vehicles against kinetic energy, artillery, grenade, IED and mine blast threats. These methodologies standardize test conditions, define threat levels, describe measuring devices...

  20. A comparative study of boron and arsenic (III) rejection from brackish water by reverse osmosis membranes

    KAUST Repository

    Teychene, Benoît

    2013-02-01

    This study aims to compare at lab-scale the rejection efficiency of several reverse osmosis membranes (RO) toward arsenic (III) and boron during the filtration of a synthetic brackish water. The effect of pH and operating conditions on the rejection of each RO membrane was studied. Two types of membrane were investigated: "brackish water" and "sea water" membranes. Our results showed that the metalloid rejection depends on the membrane type, pH and transmembrane pressure applied. Increasing pH above the dissociation constant (pKa) of each specie improves significantly the metalloid rejection by RO membranes, whatever the membrane type. Moreover, at identical operating conditions (pH, transmembrane pressure), results showed that the brackish water membranes have a higher water flux and exhibit lower metalloid rejection. The highest As(III) rejection value for the tested brackish water membranes was 99% obtained at pH = 9.6 and 40 bars, whereas it was found that the sea water RO membranes could highly reject As(III), more than 99%, even at low pH and low pressure (pH = 7.6 and 24 bars).Regarding Boron rejection, similar conclusions could be drawn. The sea water RO membranes exert higher removal, with a high rejection value above 96% over the tested conditions. More generally, this study showed that, whatever the operating conditions or the tested membranes, the boron and As(III) permeate concentrations are below the WHO guidelines. In addition, new data about the boron and arsenic permeability of each tested RO membrane was brought thanks to a theoretical calculation. © 2012 Elsevier B.V.

  1. Spectroscopic studies on the interaction of europium(III) and curium(III) with components of the human mucosa

    Energy Technology Data Exchange (ETDEWEB)

    Wilke, Claudia; Barkleit, Astrid [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Div. Chemistry of the F-Elements

    2016-07-01

    To evaluate the health risks of lanthanides (Ln) and radiotoxic actinides (An) in case of ingestion accidents etc., investigations into the chemical reactions of these metals in the human gastrointestinal tract are necessary. Our previous study revealed that mucin, an important part of the protective mucosa layer in the digestive system, shows a strong interaction with Eu(III). Based on these results, the present study focuses on the components of this glycoprotein and identified N-acetylneuraminic acid (NANA) as the dominant binding carbohydrate of mucin. TRLFS measurements suggest the formation of a 1: 1 complex with log β of 3.2 ± 0.1 for Eu(III) and 3.3 ± 0.1 for Cm(III), respectively.

  2. CO2 Washout Testing Using Various Inlet Vent Configurations in the Mark-III Space Suit

    Science.gov (United States)

    Korona, F. Adam; Norcross, Jason; Conger, Bruce; Navarro, Moses

    2014-01-01

    Requirements for using a space suit during ground testing include providing adequate carbon dioxide (CO2) washout for the suited subject. Acute CO2 exposure can lead to symptoms including headache, dyspnea, lethargy and eventually unconsciousness or even death. Symptoms depend on several factors including inspired partial pressure of CO2 (ppCO2), duration of exposure, metabolic rate of the subject and physiological differences between subjects. Computational Fluid Dynamic (CFD) analysis has predicted that the configuration of the suit inlet vent has a significant effect on oronasal CO2 concentrations. The main objective of this test was to characterize inspired oronasal ppCO2 for a variety of inlet vent configurations in the Mark-III suit across a range of workload and flow rates. Data and trends observed during testing along with refined CFD models will be used to help design an inlet vent configuration for the Z-2 space suit. The testing methodology used in this test builds upon past CO2 washout testing performed on the Z-1 suit, Rear Entry I-Suit (REI) and the Enhanced Mobility Advanced Crew Escape Suit (EM-ACES). Three subjects performed two test sessions each in the Mark-III suit to allow for comparison between tests. Six different helmet inlet vent configurations were evaluated during each test session. Suit pressure was maintained at 4.3 psid. Suited test subjects walked on a treadmill to generate metabolic workloads of approximately 2000 and 3000 BTU/hr. Supply airflow rates of 6 and 4 actual cubic feet per minute (ACFM) were tested at each workload. Subjects wore an oronasal mask with an open port in front of the mouth and were allowed to breathe freely. Oronasal ppCO2 was monitored real-time via gas analyzers with sampling tubes connected to the oronasal mask. Metabolic rate was calculated from the total oxygen consumption and CO2 production measured by additional gas analyzers at the air outlet from the suit. Real-time metabolic rate measurements were

  3. Nosely III Settlement by Results of Studies in 2008

    Directory of Open Access Journals (Sweden)

    Mikheev Alexey V.

    2016-03-01

    Full Text Available The article peresents results of new archaeological studies of the medieval horizon of Nosely III settlement in Mari Volga region. It contains defi nitions of objects connected with the medieval layer (household pits. The authors provide results of analysis of the ceramic material represented by the local (hand-made, early wheel and “Slavicoid” ceramics and imported (wheel-made Russian and Bulgar-Horde ware and complex of items. New materials allow us to provide a more precise dating of the settlement and limit the time of its existence to 14th – 15th centuries and defi ne it as a Mari rural settlement belonging to the district of the Maly Sundyr (Vazhnanger hillfort.

  4. Interlaboratory study comparing the microbiological potency of spiramycins I, II and III.

    Science.gov (United States)

    Liu, L; Saevels, J; Louis, P; Nelis, H; Rico, S; Dierick, K; Guyomard, S; Roets, E; Hoogmartens, J

    1999-06-01

    An interlaboratory study has been performed to determine the relative potencies of spiramycins (SPMs) I, II and III by diffusion or/and turbidimetric assays with Bacillus subtilis or Staphylococcus aureus as the test organisms. Six laboratories from three countries participated. Experimental procedures were according to the European Pharmacopoeia, 3rd ed. The activity of SPM I is markedly higher than that of SPM II and III. By diffusion, the activities of SPM II and III relative to SPM I were found to be 57 and 72%, respectively. The interlaboratory relative standard deviations (RSD) varied from 3.6 to 16.3%. By turbidimetry, the activities of SPM II and III relative to SPM I were found to be 45 and 52%, respectively. The interlaboratory RSD values varied from 2.6 to 7.7%. The results of the study were analyzed according to the ISO 5725-2 guidelines to determine the repeatability, the between-laboratory and the reproducibility variances of both methods.

  5. Soft Tissue Characteristics and Gender Dimorphism in Class III Malocclusion: a Cephalometric Study in Adult Greeks

    Directory of Open Access Journals (Sweden)

    Kavvadia Smaragda

    2017-11-01

    Full Text Available Background/Aim: Class III malocclusion case are considered complex problems associated with unacceptable esthetics. The purpose of the present study was to assess the characteristics of the soft tissue profile and investigate the possible gender differences in adult Greeks with Class III malocclusion. Material and Methods: The material of the study comprised of 57 pretreatment lateral cephalograms of adult patients with Class III malocclusion aged 18 to 39 years. Eleven variables were assessed. The variables were measured and the mean, minimum and maximum and standard deviations were calculated. Parametric and non-parametric tests were used to compare males and females patients. Results: The total sample was characterized by concave skeletal profile. Male patients exhibited greater nose prominence and superior sulcus depth, longer distance from subnasale to the harmony line, more concave profile, thicker upper lip and larger upper lip strain. Conclusions: Many significant differences were noted in soft tissue characteristics between males and females with skeletal Class III malocclusion, suggesting possible gender dimorphism.

  6. Electromagnetic Compatibility Testing Studies

    Science.gov (United States)

    Trost, Thomas F.; Mitra, Atindra K.

    1996-01-01

    This report discusses the results on analytical models and measurement and simulation of statistical properties from a study of microwave reverberation (mode-stirred) chambers performed at Texas Tech University. Two analytical models of power transfer vs. frequency in a chamber, one for antenna-to-antenna transfer and the other for antenna to D-dot sensor, were experimentally validated in our chamber. Two examples are presented of the measurement and calculation of chamber Q, one for each of the models. Measurements of EM power density validate a theoretical probability distribution on and away from the chamber walls and also yield a distribution with larger standard deviation at frequencies below the range of validity of the theory. Measurements of EM power density at pairs of points which validate a theoretical spatial correlation function on the chamber walls and also yield a correlation function with larger correlation length, R(sub corr), at frequencies below the range of validity of the theory. A numerical simulation, employing a rectangular cavity with a moving wall shows agreement with the measurements. The determination that the lowest frequency at which the theoretical spatial correlation function is valid in our chamber is considerably higher than the lowest frequency recommended by current guidelines for utilizing reverberation chambers in EMC testing. Two suggestions have been made for future studies related to EMC testing.

  7. An introduction to testing techniques in the INTELSAT TDMA/DSI system. III - Specialized test equipment for SSOG tests

    Science.gov (United States)

    Colby, R. J.; Parthasarathy, R.; Prouse, D. W.

    1984-09-01

    Attention is given to those features of TDMA which affect test equipment design, and to the three specialized test equipment types which must be employed in system tests and the line-up of individual links. These instruments are the Burst Mode Link Analyzer, the Burst Negator and Contrived Loop, and the Pulse Code Modulation/Digital Speech Interpolation test set. Prototypes are currently being developed under Intelsat contracts for evaluation during the preoperational phase.

  8. Standard test method for plutonium assay by plutonium (III) diode array spectrophotometry

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2002-01-01

    1.1 This test method describes the determination of total plutonium as plutonium(III) in nitrate and chloride solutions. The technique is applicable to solutions of plutonium dioxide powders and pellets (Test Methods C 697), nuclear grade mixed oxides (Test Methods C 698), plutonium metal (Test Methods C 758), and plutonium nitrate solutions (Test Methods C 759). Solid samples are dissolved using the appropriate dissolution techniques described in Practice C 1168. The use of this technique for other plutonium-bearing materials has been reported (1-5), but final determination of applicability must be made by the user. The applicable concentration range for plutonium sample solutions is 10–200 g Pu/L. 1.2 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropria...

  9. Lubrication studies of some type III deep eutectic solvents (DESs)

    Science.gov (United States)

    Ahmed, Essa. I.; Abbott, Andrew. P.; Ryder, Karl S.

    2017-09-01

    It has previously been shown that eutectic mixtures of quaternary ammonium salts and hydrogen bond donors form liquids with properties similar to ionic liquids [1; 2]. These so-called deep eutectic solvents (DESs) have been shown to have physical properties which would make them useful as base lubricants. The base lubricant needs to show specific properties, including high viscosity index (VI), low friction coefficient (μ), low pour point and corrosivity. To determine the applicability of DESs as base lubricants, physical properties, corrosion and lubrication properties for four type III DESs have been studied and the results have been compared with mineral base oil. The data show that the lubrication properties of DESs are superior to mineral base oil for short distances. All DESs assessed here have higher VI (191, 147, 121 for Ethaline, Glyceline and Reline respectively compared with 100 for mineral base oil), lower pour points than mineral base oil and most of the liquids studied have shown very low corrosion rates (< 3 µm year-1 for mild steel).

  10. The groningen longitudinal glaucoma study III. The predictive value of frequency-doubling perimetry and GDx nerve fibre analyser test results for the development of glaucomatous visual field loss

    NARCIS (Netherlands)

    Heeg, G. P.; Jansonius, N. M.

    Purpose To investigate whether frequency-doubling perimetry (FDT) and nerve fibre analyser (GDx) test results are able to predict glaucomatous visual field loss in glaucoma suspect patients. Methods A large cohort of glaucoma suspect patients (patients with ocular hypertension or a positive family

  11. The association of tongue posture with the dentoalveolar maxillary and mandibular morphology in Class III malocclusion: a controlled study.

    Science.gov (United States)

    Primozic, Jasmina; Farcnik, Franc; Perinetti, Giuseppe; Richmond, Stephen; Ovsenik, Maja

    2013-06-01

    The aim of the present study was to evaluate the association of tongue posture with the dentoalveolar maxillary and mandibular morphology in a group of Class III subjects in comparison to a group of Class I subjects. Twenty Class III subjects (9 males, 11 females, 19.2 ± 4.6 years) and 20 Class I subjects (6 males, 14 females, 17.4 ± 1.7 years) were included in the present study. Maxillary and mandibular morphology was defined by the intermolar and intercanine distances, at both the cusps and gingival levels, and by measuring surface area and volume of the palatal vault and mouth floor assessed on three-dimensional digital models. Tongue-to-palate distances were measured on lateral cephalograms. The groups were compared using the Mann-Whitney U-test and correlations between each morphological parameter and the tongue-to-palate distances were calculated using the Spearman correlation coefficient. The mandibular intermolar width at the gingival level was significantly greater in the Class III group (P Class III group (P Class III group (P = 0.01). The tongue-to-palate distances were generally greater, i.e. lower tongue posture, for the Class III subjects. Significant correlations were seen between tongue-to-palate distances in the posterior region with the area ratio (rho = 0.44, P Class III subjects and is associated with the dentoalveolar characteristics of the maxilla and mandible.

  12. Reactor physics studies in the GCFR Phase III critical assembly

    Energy Technology Data Exchange (ETDEWEB)

    Morman, J A [ed.

    1980-03-01

    The third phase of the gas cooled fast reactor (GCFR) program, ZPR-9 Assembly 30, is based on a multi-zoned core of PuO/sub 2/-UO/sub 2/ with radial and axial blankets of UO/sub 2/. Studies performed in this assembly will be compared to the previous phases of the GCFR program and will help to define parameters in this power-flattened demonstration plant-type core. Measurements in the Phase III program included small sample reactivity worths of various materials, central reaction rates and reaction rate distributions, absorption-to-fission ratios and the central point conversion ratio and the worth of steam entry into a small central zone. The reactivity change associated with the construction of a central pin zone in the core and axial blanket was measured. Reaction rate and steam entry measurements were repeated in the pin environment. Standard analysis methods using ENDF/B-IV data are described and the results are compared to measurements performed during the program.

  13. [Spectral study of two Bi (III) contained heteropolymate compounds].

    Science.gov (United States)

    Wang, Yong-Jing; Zhang, Han-Hui; Huang, Chang-Cang; Chen, Yi-Ping; Sun, Rui-Qing

    2006-02-01

    Two Bi (III) contained heteropolymate compounds Cos [Bi2 Co2 W20 O70 (H2O)6] x 44H2O (I)and Na3 H2 [Ce3 (H2O)18 Bi2 W22 O76] x 23H2O (II) have been synthesized under hydrothermal condition. The relationship between their properties and structures was studied by using FTIR, NIR FT-Raman, and UV-Vis DRS etc. The characteristic vibrational frequencies nu(as) (M = O(d)) and nu(s) (M-O(b)-M) is related to the structure of the materials. Nu(as) (M-O(b)-M) is demonstrated to explain why the the oxidative ability becomes stronger when W atoms are substituted by Co atoms. In UV-Vis DRS spectra of compound I and II, there are two characteristic peaks at 254, 319 nm and 220, 310 nm coresponding O(d) --> W and to O(b), c --> W charge transfer, respectively. The wide and weak absorption band of compound I at 529 nm can be assigned as Co2+ d-d transfer. Finally, quantum chemistry calculation of compound I was performed to explain the structure characteristic.

  14. Regeneration Study Test Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data (2 excel files) consist of the analytical test results on water sample collected from the two adsorption media tanks of the arsenic removal system during the...

  15. Efficient Removal of Ce(III and Eu(III Ions from Aqueous Solutions by Local Clay -A Radiotracer Study

    Directory of Open Access Journals (Sweden)

    Som Shankar Dubey

    2011-01-01

    Full Text Available Radiotracer technique has been used to study the removal behavior of Ce(III and Eu(III ions from aqueous solutions by local clay. Adsorptive concentration (10-4–10-6 mol dm-3, pH (ca 2.0-9.0 and temperature (303-333 K were examined for assessing optimal conditions for removal of these ions. The adsorption phenomenon was highly dependent on the amount of the adsorbent concentrations. The uptake of ions, which fitted well for Freundlich isotherm, increased with increase in the temperature and no significant desorption took place in the studied temperature range. The energy of adsorption process for the both cations indicates that the adsorption phenomenon is of chemisorption type. The rate kinetics of the adsorption followed the first order rate kinetics.

  16. The Validity of the Bayley-III and DDST-II in Preterm Infants With Neurodevelopmental Impairment: A Pilot Study.

    Science.gov (United States)

    Jeong, Seong Uk; Kim, Ghi Chan; Jeong, Ho Joong; Kim, Dong Kyu; Hong, Yoo Rha; Kim, Hui Dong; Park, Seok Gyo; Sim, Young-Joo

    2017-10-01

    To identify the usefulness of both the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III) and Denver Developmental Screening Test II (DDST-II) in preterm babies with neurodevelopmental impairment, considering the detection rate as regulation of criteria. Retrospective medical chart reviews which included the Bayley-III and DDST-II, were conducted for 69 preterm babies. Detection rate of neurodevelopmental impairment in preterm babies were investigated by modulating scaled score of the Bayley-III. The detection rate of DDST-II was identified by regarding more than 1 caution as an abnormality. Then detection rates of each corrected age group were verified using conventional criteria. When applying conventional criteria, 22 infants and 35 infants were detected as preterm babies with neurodevelopmental impairment, as per the Bayley-III and DDST-II evaluation, respectively. Detection rates increased by applying abnormal criteria that specified as less than 11 points in the Bayley-III scaled score. In DDST-II, detection rates rose from 50% to 68.6% using modified criteria. The detection rates were highest when performed after 12 months corrected age, being 100% in DDST II. The detection rate also increased when applying the modified criteria in both the Bayley-III and DDST-II. Accurate neurologic examination is more important for detection of preterm babies with neurodevelopmental impairment. We suggest further studies for the accurate modification of the detection criteria in DDST-II and the Bayley-III for preterm babies.

  17. Studies of Some Lanthanide(III Nitrate Complexes of Schiff Base Ligands

    Directory of Open Access Journals (Sweden)

    Kishor Arora Mukesh Sharma

    2009-01-01

    Full Text Available The studies of 16 new lanthanide(III nitrate complexes of Schiff base ligands are discussed. Schiff bases were obtained by the condensation of 2–methyl–4–N,N–bis–2' –cyanoethyl aminobenzaldehyde with aniline and 3 different substituted anilines. Lanthanide(III nitrates, viz. gadolinium(III nitrate, lanthanum(III nitrate, samarium(III nitrate and cerium(III nitrate were chosen to synthesize new complexes. The complexes were characterized on the basis of physicochemical studies viz. elemental analysis, spectral, viz. IR and electronic spectral and magnetic studies. TGA studies of some of the representative complexes were also done. Some of the representative complexes were also screened for the anti microbial studies.

  18. Diglycolic acid modified zirconium phosphate and studies on the extraction of Am(III) and Eu(III) from dilute nitric acid medium

    Energy Technology Data Exchange (ETDEWEB)

    Selvan, B. Robert; Suneesh, A.S.; Venkatesan, K.A.; Antony, M.P. [Indira Gandhi Centre for Atomic Research, Kalpakkam (India). Fuel Chemistry Division; Dasthaiah, K.; Gardas, R.L. [Indian Institute of Technology - Madras, Chennai (India). Dept. of Chemistry

    2017-06-01

    Diglycolic acid modified zirconium phosphate (ZrP-DGA) was prepared and studied for the extraction of Am(III) and Eu(III) from dilute nitric acid medium. The distribution coefficient (K{sub d}, mL.g{sup -1}) of Am(III) and Eu(III) was measured as a function of time, pH and concentration of Eu(III) ion etc. The K{sub d} of Am(III) and Eu(III) increased with increase of pH, reached a maximum value of distribution coefficient at pH 1.5 - 2, followed by decrease in K{sub d} values. Rapid extraction of Am(III) and Eu(III) in ZrP-DGA was observed followed by the establishment of equilibrium occurred in 100 min. Kinetics of extraction was fitted in to pseudo second order rate equation. The amount of Eu(III) loaded in ZrP-DGA increased with increase in the concentration of Eu(III) ion in aqueous phase and the isotherm was fitted in to Langmuir and Freundlich adsorption models. The extraction of Am(III) in ZrP-DGA was higher as compared to Eu(III) and the interference of Eu(III) on the extraction of Am(III) was studied. The distribution coefficient of some lanthanides in ZrP-DGA was measured and the K{sub d} of lanthanides increased across the lanthanide series. The extracted trivalent metal ions were recovered in three contacts of loaded ZrP-DGA with 0.5 M nitric acid.

  19. Disc position in clinically asymptomatic, pretreatment adolescents with Class I, II, or III malocclusion : A retrospective magnetic resonance imaging study.

    Science.gov (United States)

    Gökalp, Hatice

    2016-05-01

    To test the null hypothesis that children with Class I, II, and III malocclusions who have not undergone orthodontic therapy present with displaced discs. This study relied on retrospective material consisting of 76 unilateral left sagittal-oblique temporomandibular joint (TMJ) magnetic resonance imaging (MRIs) and lateral cephalometric radiographs taken in maximum intercuspal position in patients with clinically symptom-free and orthodontically untreated Class I (n = 30; 19 girls and 11 boys), Class II (n = 26; 10 girls and 16 boys), and Class III malocclusion (n = 20; 5 girls and 15 boys). The mean ages of patients with Class I, II, and III malocclusions were 10.55 ± 0.81, 11.71 ± 0.31, and 8.98 ± 1.80 years, respectively. Study groups were compared with one-way ANOVA analysis or Welch ANOVA test. Differences were evaluated via the Tukey HSD or Games-Howell test. Disc-condyle positions were almost within normal limits in Class I malocclusion. The disc was positioned anteriorly relative to the condyle (p Class II malocclusion (p Class III malocclusion. Disc-condyle positions were observed to be almost identical in all three malocclusion classes. Disc-condyle position was nearly normal in patients with Class I malocclusion. Nevertheless, a Class II malocclusion is more apt to reveal anterior disc displacement than a Class III malocclusion.

  20. Bone fracture characterization under mixed-mode I+II loading using the single leg bending test.

    Science.gov (United States)

    Pereira, F A M; de Moura, M F S F; Dourado, N; Morais, J J L; Dias, M I R

    2014-11-01

    Fracture under mixed-mode I+II was induced in bovine cortical bone tissue using a developed miniaturized version of the single leg bending test (SLB). Due to the difficulty in crack length monitoring in the course of the test, an equivalent crack method based on specimen compliance and beam theory was adopted as a data reduction scheme. The method was applied to the experimental results in order to obtain the Resistance curves in each loading mode. The determined fracture energy is well described by an energetic power law whose exponent is below one, which means that the linear energetic criterion is not applicable to this material. The proposed procedure was numerically validated by means of a cohesive mixed-mode I+II damage model with bilinear softening. It was concluded that the miniaturized version of the SLB test is adequate for mixed-mode I+II fracture characterization of bone for a constant mode ratio.

  1. Functional conservation of RNase III-like enzymes: studies on a Vibrio vulnificus ortholog of Escherichia coli RNase III.

    Science.gov (United States)

    Lee, Minho; Ahn, Sangmi; Lim, Boram; Lee, Dong-Ho; Lee, Kangseok

    2014-04-01

    Bacterial ribonuclease III (RNase III) belongs to the RNase III enzyme family, which plays a pivotal role in controlling mRNA stability and RNA processing in both prokaryotes and eukaryotes. In the Vibrio vulnificus genome, one open reading frame encodes a protein homologous to E. coli RNase III, designated Vv-RNase III, which has 77.9 % amino acid identity to E. coli RNase III. Here, we report that Vv-RNase III has the same cleavage specificity as E. coli RNase III in vivo and in vitro. Expressing Vv-RNase III in E. coli cells deleted for the RNase III gene (rnc) restored normal rRNA processing and, consequently, growth rates of these cells comparable to wild-type cells. In vitro cleavage assays further showed that Vv-RNase III has the same cleavage activity and specificity as E. coli RNase III on RNase III-targeted sequences of corA and mltD mRNA. Our findings suggest that RNase III-like proteins have conserved cleavage specificity across bacterial species.

  2. Independent Validation and Clinical Utility Study of the Hellenic WISC-III Using a Greek-Cypriot Sample

    Science.gov (United States)

    Souroulla, Andry Vrachimi; Panayiotou, Georgia

    2017-01-01

    The Hellenic WISC-III (Wechsler, 1997) is currently the only standardized and officially published tool for the assessment of the intelligence of children and adolescents in Greece. The test is also used with caution in Cyprus, among Greek speakers, but no specific norms exist for use in this country. The purpose of this study was to provide…

  3. 46 CFR Appendix III to Part 150 - Testing Procedures for Determining Exceptions to the Chart

    Science.gov (United States)

    2010-10-01

    ... Chart III Appendix III to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Procedures for Determining Exceptions to the Chart experimental procedure for evaluating binary chemical... is joined, while the other wire of each is connected to a strip-chart recorder. The thermocouple...

  4. Validation of the WMS-III Facial Memory subtest with the Graduate Hospital Facial Memory Test in a sample of right and left anterior temporal lobectomy patients.

    Science.gov (United States)

    Chiaravalloti, Nancy D; Tulsky, David S; Glosser, Guila

    2004-06-01

    A number of studies have shown visuospatial memory deficits following anterior temporal lobectomy (ATL) in the right, nondominant temporal lobe (RATL). The current study examines 26 patients with intractable temporal lobe epilepsy who underwent ATL in either the right (RATL, n = 16) or left temporal lobe (LATL, n = 10) on two tests of facial memory abilities, the Wechsler Memory Scale-III (WMS-III) Faces subtest and the Graduate Hospital Facial Memory Test (FMT). Repeated measures ANOVA on the FMT indicated a significant main effect of side of surgery. The RATL group performed significantly below the LATL group overall. Both groups showed a slight, but non-significant, improvement in performance from pre- to postsurgery on the FMT immediate memory, likely due to practice effects. Repeated measures ANOVA on the WMS-III Faces subtest revealed a significant interaction of group (RATL vs. LATL) by delay (immediate vs. delayed). Overall, the LATL group showed an improvement in recognition scores from immediate to delayed memory, whereas the RATL group performed similarly at both immediate and delayed testing. No effects of surgery were noted on the WMS-III. Following initial data analysis the WMS-III Faces I and II data were re-scored using the scoring suggested by Holdnack and Delis (2003), earlier in this issue. Repeated measures ANOVA revealed a trend toward significance in the three-way interaction of group (RATL vs. LATL) x time of testing (pre- versus postop) x delay (immediate vs. delayed memory). On the Faces I subtest, both the RATL and LATL groups showed a decline from preoperative to postoperative testing. However, on Faces II the LATL group showed an increase in performance from preoperative to postoperative testing, while the RALT group showed a decline in performance from preoperative to postoperative testing. While the FMT appears to be superior to the WMS-III Faces subtest in identifying deficits in facial memory prior to and following RATL, the

  5. Prevalence of metabolic syndrome according to Adult Treatment Panel III and International Diabetes Federation criteria: a population-based study.

    Science.gov (United States)

    Bener, Abdulbari; Zirie, Mahmoud; Musallam, Manal; Khader, Yousef S; Al-Hamaq, Abdulla O A A

    2009-06-01

    The objective of the study was to examine the prevalence of metabolic syndrome among adult Qatari population according to the revised criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF), assess which component contributed to the increased risk of the metabolic syndrome, and identify the characteristics of the subjects with metabolic syndrome. This was a cross-sectional study. The survey was carried out in urban and semiurban primary health-care centers. The survey was conducted from January, 2007, to July, 2008, among Qatari nationals above 20 years of age. Of the 1496 subjects who were approached to participate in the study, 1204 (80.5%) gave their consent. Face-to-face interviews were conducted using a structured questionnaire followed by laboratory tests. Metabolic syndrome was defined using the NCEP ATP III as well as IDF criteria. The overall prevalence of metabolic syndrome in studied subjects was 26.5% and 33.7% according to ATP III and IDF criteria (P III and IDF increased with age and body mass index (BMI), whereas it decreased with higher education and physical activity. Also, the prevalence of metabolic syndrome was more common in women. Among the components of metabolic syndrome, central obesity was significantly higher in the studied subjects. The IDF definition of metabolic syndrome gave a higher prevalence in all age groups. The overall prevalence of metabolic syndrome and its components according to IDF criteria was higher in the studied subjects than the estimates given by the ATP III. Multivariate logistics regression analysis (ATP III and IDF) showed that age and BMI were significant contributors for metabolic syndrome. Both definitions strongly supported age and obesity as associated factors for metabolic syndrome. The current study found a high prevalence of metabolic syndrome among Qataris. There was a steady increase in the prevalence of metabolic

  6. 77 FR 40936 - 60-Day Notice of Proposed Information Collection: Passport Demand Forecasting Study Phase III

    Science.gov (United States)

    2012-07-11

    ... Notice of Proposed Information Collection: Passport Demand Forecasting Study Phase III ACTION: Notice of...: Passport Demand Forecasting Study Phase III. OMB Control Number: None. Type of Request: Reinstatement of a... the use of automated collection techniques or other forms of technology. Abstract of proposed...

  7. Mechanistic study of ruthenium (III) catalysed oxidation of L-lysine by ...

    Indian Academy of Sciences (India)

    Administrator

    Mechanistic study of ruthenium (III) catalysed oxidation of L-lysine by diperiodatoargentate (III) in aqueous alkaline medium. R R HOSAMANI and S T NANDIBEWOOR*. PG Department of Studies in Chemistry, Karnatak University, Dharwad 580 003 e-mail: stnandibewoor@yahoo.com. MS received 15 April 2008; revised 2 ...

  8. Propriedades psicométricas dos itens do teste WISC-III Propiedades psicométricas de los ítenes del subtest WISC-III Psychometric properties of WISC-III items

    Directory of Open Access Journals (Sweden)

    Vera Lúcia Marques de Figueiredo

    2008-09-01

    Full Text Available O aperfeiçoamento de um teste se dá através da seleção, substituição ou revisão de itens, e quando um item é analisado, aumenta a validade e precisão do teste. Este artigo trata da apresentação dos resultados relativos às propriedades psicométricas dos itens dos subtestes do WISC-III, referentes a dificuldade, discriminação e validade. O WISC-III é um instrumento amplamente utilizado no contexto da avaliação da inteligência, e conhecer a qualidade dos itens é essencial ao profissional que administra o teste. As análises foram efetuadas com base nas pontuações de 801 protocolos do teste, aplicados por ocasião da pesquisa de adaptação a um contexto brasileiro. As análises mostraram que os itens adaptados apresentaram características psicométricas adequadas, possibilitando a utilização do instrumento como meio confiável de diagnóstico.El perfeccionamiento de un teste ocurre por la selección, sustitución o revisión de ítenes y, cuando un item es analisado, aumenta la validez y fiabilidad del teste. Ese artículo trata de la presentación de los resultados relativos a las propiedades psicométricas de los ítenes del subtest WISC-III, referentes a la dificultad, a la discriminación y a la validez. El WISC-III es un instrumento muy utilizado en el contexto de la evaluación de la inteligencia, y conocer a la calidad de los ítenes es esencial al profesional que administra el teste. Los análisis fueron efectuados con base el los puntajes de 801 protocolos de registro del teste, aplicados por ocasión de encuesta de estandarización a un contexto brasileño. Los análisis enseñaron que los ítenes adaptados apuntaron características psicométricas adecuadas, permitiendo la utilización del instrumento como medio confiable de diagnóstico.The improvement of the quality of items by selection, substitution and review will increase a test's validity and reliability. Current essay will present results referring to

  9. Characterization of the Edge Crack Torsion (ECT) Test for Mode III Fracture Toughness Measurement of Laminated Composites

    Science.gov (United States)

    Ratcliffe, James G.

    2004-01-01

    The edge crack torsion (ECT) test is designed to initiate mode III delamination growth in composite laminates. The test has undergone several design changes during its development. The objective of this paper was to determine the suitability of the current ECT test design a mode III fracture test. To this end, ECT tests were conducted on specimens manufactured from IM7/8552 and S2/8552 tape laminates. Three-dimensional finite element analyses were performed. The analysis results were used to calculate the distribution of mode I, mode II, and mode III strain energy release rate along the delamination front. The results indicated that mode IIIdominated delamination growth would be initiated from the specimen center. However, in specimens of both material types, the measured values of GIIIc exhibited significant dependence on delamination length. Load-displacement response of the specimens exhibited significant deviation from linearity before specimen failure. X-radiographs of a sample of specimens revealed that damage was initiated in the specimens prior to failure. Further inspection of the failure surfaces is required to identify the damage and determine that mode III delamination is initiated in the specimens.

  10. A statistical study of solar type III bursts and auroral kilometric radiation onsets

    Science.gov (United States)

    Farrell, W. M.; Gurnett, D. A.

    1985-01-01

    Simultaneous occurrences of type III solar radio bursts and auroral kilometric radiation were observed by Calvert (1981) using ISEE 1 spectrograms. Calvert presented evidence suggesting that the incoming type III burst stimulates the onset of auroral kilometric radiation (AKR). This paper presents a statistical study of the correlation between type III bursts and auroral kilometric radiation. A superposed epoch analysis was performed on as many as 186 type III events. The type III bursts were detected by the ISEE 3 spacecraft on the sunward side of the earth. At the same time the IMP 8 spacecraft was used to detect onsets of kilometric radiation on the nightside of the earth. For each event the intensities measured by ISEE 3 (type III intensities) were subtracted from the intensities measured by IMP 8 (type III and possible AKR intensities). The resulting intensities for each event were then added to determine if kilometric radiation was preferentially observed following a type III burst. This analysis was performed at frequencies of 100, 178, and 500 kHz. The results of this study show that a statistically significant correlation exists between incoming type III bursts from the sun and kilometric radiation from the earth.

  11. Inhibition of microbial trichloroethylene dechlorination [corrected] by Fe (III) reduction depends on Fe mineralogy: a batch study using the bioaugmentation culture KB-1.

    Science.gov (United States)

    Paul, Laiby; Herrmann, Steffi; Koch, Christian Bender; Philips, Jo; Smolders, Erik

    2013-05-01

    Microbial reductive dechlorination of trichloroethylene (TCE) in groundwater can be stimulated by adding of electron donors. However, side reactions such as Fe (III) reduction competes with this reaction. This study was set-up to relate the inhibition of microbial TCE dechlorination to the quantity and quality (mineralogy) of Fe (III) in the substrate and to calibrate a substrate extraction procedure for testing bioavailable Fe (III) in sediments. Batch experiments were set-up with identical inoculum (KB-1 culture) and liquid medium composition, and adding either 1) variable amounts of ferrihydrite or 2) 14 different Fe (III) minerals coated onto or mixed in with quartz sand (at constant total Fe) at a stoichiometric excess Fe (III) over electron donor. Increasing amounts of ferrihydrite significantly increased the time for complete TCE degradation from 8 days (control sand) to 28 days (excess Fe). Acid extractable Fe (II) increased and magnetite formed during incubation, confirming Fe (III) reduction. At constant total Fe in the sand, TCE dechlorination time varied with Fe mineralogy between 8 days (no Fe added) to >120 days (Fe-containing bentonite). In general, poorly crystalline Fe (III) minerals inhibited TCE dechlorination whereas crystalline Fe (III) minerals such as goethite or hematite had no effect. The TCE inhibition time was positively correlated to the Fe (II) determined after 122 days and to the surface area of the Fe (III) minerals. Only a fraction of total Fe (III) is reduced, likely because of solubility constraints and/or coating of Fe (III) minerals by Fe (II) minerals. Iron extraction tests based on Fe (III) reduction using NH2OH(.)HCl predict the competitive inhibition of TCE degradation in these model systems. This study shows that Fe mineralogy rather that total Fe content determines the competitive inhibition of TCE dechlorination. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. The nature of the intermediates in the reactions of Fe(III)- and Mn(III)-microperoxidase-8 with H(2)O(2): a rapid kinetics study.

    Science.gov (United States)

    Primus, Jean-Louis; Grunenwald, Sylvie; Hagedoorn, Peter-Leon; Albrecht-Gary, Anne-Marie; Mandon, Dominique; Veeger, Cees

    2002-02-20

    Kinetic studies were performed with microperoxidase-8 (Fe(III)MP-8), the proteolytic breakdown product of horse heart cytochrome c containing an octapeptide linked to an iron protoporphyrin IX. Mn(III) was substituted for Fe(III) in Mn(III)MP-8. The mechanism of formation of the reactive metal-oxo and metal-hydroperoxo intermediates of M(III)MP-8 upon reaction of H(2)O(2) with Fe(III)MP-8 and Mn(III)MP-8 was investigated by rapid-scan stopped-flow spectroscopy and transient EPR. Two steps (k(obs1) and k(obs2)) were observed and analyzed for the reaction of hydrogen peroxide with both catalysts. The plots of k(obs1) as function of [H(2)O(2)] at pH 8.0 and pH 9.1 for Fe(III)MP-8, and at pH 10.2 and pH 10.9 for Mn(III)MP-8, exhibit saturation kinetics, which reveal the accumulation of an intermediate. Double reciprocal plots of 1/k(obs1) as function of 1/[H(2)O(2)] at different pH values reveal a competitive effect of protons in the oxidation of M(III)MP-8. This effect of protons is confirmed by the linear dependence of 1/k(obs1) on [H(+)] showing that k(obs1) increases with the pH. The UV-visible spectra of the intermediates formed at the end of the first step (k(obs1)) exhibit a spectrum characteristic of a high-valent metal-oxo intermediate for both catalysts. Transient EPR of Mn(III)MP-8 incubated with an excess of H(2)O(2), at pH 11.5, shows the detection of a free radical signal at g approximately equal to 2 and of a resonance at g approximately equal to 4 characteristic of a Mn(IV) (S = 3/2) species. On the basis of these results, the following mechanism is proposed: (i) M(III)MP-8-OH(2) is deprotonated to M(III)MP-8-OH in a rapid preequilibrium step, with a pK(a) = 9.2 +/- 0.9 for Fe(III)MP-8 and a pK(a) = 11.2 +/- 0.3 for Mn(III)MP-8; (ii) M(III)MP-8-OH reacts with H(2)O(2) to form Compound 0, M(III)MP8-OOH, with a second-order rate constant k(1) = (1.3 +/- 0.6) x 10(6) M(-1) x s(-1) for Fe(III)MP-8 and k(1) = (1.6 +/- 0.9) x 10(5) M(-1) x s(-1) for Mn(III

  13. Using phase II data for the analysis of phase III studies: An application in rare diseases.

    Science.gov (United States)

    Wandel, Simon; Neuenschwander, Beat; Röver, Christian; Friede, Tim

    2017-06-01

    Clinical research and drug development in orphan diseases are challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is therefore of great value, yet this is rarely done in the drug-approval process. Phase III designs that make better use of phase II data can facilitate drug development in orphan diseases. A Bayesian meta-analytic approach is used to inform the phase III study with phase II data. It is particularly attractive, since uncertainty of between-trial heterogeneity can be dealt with probabilistically, which is critical if the number of studies is small. Furthermore, it allows quantifying and discounting the phase II data through the predictive distribution relevant for phase III. A phase III design is proposed which uses the phase II data and considers approval based on a phase III interim analysis. The design is illustrated with a non-inferiority case study from a Food and Drug Administration approval in herpetic keratitis (an orphan disease). Design operating characteristics are compared to those of a traditional design, which ignores the phase II data. An analysis of the phase II data reveals good but insufficient evidence for non-inferiority, highlighting the need for a phase III study. For the phase III study supported by phase II data, the interim analysis is based on half of the patients. For this design, the meta-analytic interim results are conclusive and would justify approval. In contrast, based on the phase III data only, interim results are inconclusive and require further evidence. To accelerate drug development for orphan diseases, innovative study designs and appropriate methodology are needed. Taking advantage of randomized phase II data when analyzing phase III studies looks promising because the evidence from phase II supports informed decision-making. The implementation of the Bayesian design is straightforward with public software such as R.

  14. Theory testing using case studies

    DEFF Research Database (Denmark)

    Dissing Sørensen, Pernille; Løkke Nielsen, Ann-Kristina

    Case studies may have different research goals. One such goal is the testing of small-scale and middle-range theories. Theory testing refers to the critical examination, observation, and evaluation of the 'why' and 'how' of a specified phenomenon in a particular setting. In this paper, we focus...... on the strengths of theory-testing case studies. We specify research paths associated with theory testing in case studies and present a coherent argument for the logic of theoretical development and refinement using case studies. We emphasize different uses of rival explanations and their implications for research...... design. Finally, we discuss the epistemological logic, i.e., the value to larger research programmes, of such studies and, following Lakatos, conclude that the value of theory-testing case studies lies beyond naïve falsification and in their contribution to developing research programmes in a progressive...

  15. Kinematic analysis of mandibular motion before and after orthognathic surgery for skeletal Class III malocclusion: A pilot study.

    Science.gov (United States)

    Ugolini, Alessandro; Mapelli, Andrea; Segù, Marzia; Galante, Domenico; Sidequersky, Fernanda V; Sforza, Chiarella

    2017-03-01

    The aim of the study was to detect the changes in 3D mandibular motion after orthognathic surgery for skeletal Class III malocclusion. Using a 3D motion analyzer, free mandibular border movements were recorded in nine patients successfully treated for skeletal Class III malocclusion and in nine patients scheduled for orthognathic surgery. Data were compared using Mann-Whitney non-parametric U-test. The results showed no differences between the groups in the total amount of mouth opening, protrusion, and in lateral excursions, but the percentage of mandibular movement explained by condylar translation was significantly increased after surgery (20% vs. 23.6%). During opening, the post-surgery patients showed a more symmetrical mandibular interincisal point and condylar path than pre-surgery patients (p Class III malocclusion recover a good and symmetric temporomandibular joint function.

  16. Protonation of sodium ionophore III: Extraction and DFT study

    Science.gov (United States)

    Makrlík, Emanuel; Kvíčala, Jaroslav; Vaňura, Petr

    2014-08-01

    On the basis of extraction experiments and γ-activity measurements, the extraction constant corresponding to the equilibrium H3O+(aq) + 1ṡNa+(nb) ⇆ 1ṡH3O+(nb) + Na+(aq) occurring in the two-phase water-nitrobenzene system (1 = sodium ionophore III; aq = aqueous phase, nb = nitrobenzene phase) was determined as log Kex (H3O+, 1ṡNa+) = 0.0 ± 0.1. Further, the stability constant of the 1ṡH3O+ complex in nitrobenzene saturated with water was calculated for a temperature of 25 °C: log βnb (1ṡH3O+) = 6.4 ± 0.2. Finally, by using quantum mechanical DFT calculations, the most probable structure of the cationic complex species 1ṡH3O+ was derived. In the resulting complex, the "central" cation H3O+ is bound by two linear hydrogen bonds and one bifurcated hydrogen bond to the corresponding four oxygens of the parent ligand 1. The interaction energy of the considered 1ṡH3O+ complex was found to be -556.6 kJ/mol, confirming also the formation of this cationic species.

  17. Validation of the 5th and 95th Percentile Hybrid III Anthropomorphic Test Device Finite Element Model

    Science.gov (United States)

    Lawrence, C.; Somers, J. T.; Baldwin, M. A.; Wells, J. A.; Newby, N.; Currie, N. J.

    2014-01-01

    NASA spacecraft design requirements for occupant protection are a combination of the Brinkley criteria and injury metrics extracted from anthropomorphic test devices (ATD's). For the ATD injury metrics, the requirements specify the use of the 5th percentile female Hybrid III and the 95th percentile male Hybrid III. Furthermore, each of these ATD's is required to be fitted with an articulating pelvis and a straight spine. The articulating pelvis is necessary for the ATD to fit into spacecraft seats, while the straight spine is required as injury metrics for vertical accelerations are better defined for this configuration. The requirements require that physical testing be performed with both ATD's to demonstrate compliance. Before compliance testing can be conducted, extensive modeling and simulation are required to determine appropriate test conditions, simulate conditions not feasible for testing, and assess design features to better ensure compliance testing is successful. While finite element (FE) models are currently available for many of the physical ATD's, currently there are no complete models for either the 5th percentile female or the 95th percentile male Hybrid III with a straight spine and articulating pelvis. The purpose of this work is to assess the accuracy of the existing Livermore Software Technology Corporation's FE models of the 5th and 95th percentile ATD's. To perform this assessment, a series of tests will be performed at Wright Patterson Air Force Research Lab using their horizontal impact accelerator sled test facility. The ATD's will be placed in the Orion seat with a modified-advanced-crew-escape-system (MACES) pressure suit and helmet, and driven with loadings similar to what is expected for the actual Orion vehicle during landing, launch abort, and chute deployment. Test data will be compared to analytical predictions and modelling uncertainty factors will be determined for each injury metric. Additionally, the test data will be used to

  18. Pengaruh Kesadaran dan Kepatuhan Wajib Pajak Terhadap Kinerja Perpajakan (Studi pada Kanwil Ditjen Pajak Jawa Timur III)

    OpenAIRE

    Kariyoto

    2012-01-01

    Abstract: Effect of Awareness and Taxpayer Compliance Performace of Taxation. The aim of the study is to test the influence of compliance and taxpayer awareness on the performance of taxation. The population of this research is account representative that spread across the Regional Office of Directorate General of Taxation III, East Java, while samples taken is as many as 124 respondents. Analysis of research data uses SEM (structural equation modeling). The main findings of this study sugges...

  19. Theory Testing Using Case Studies

    DEFF Research Database (Denmark)

    Møller, Ann-Kristina Løkke; Dissing Sørensen, Pernille

    2014-01-01

    testing using case studies, including the associated research goal, analysis, and generalisability. We argue that research designs for theory testing using case studies differ from theorybuilding case study research designs because different research projects serve different purposes and follow different......The appropriateness of case studies as a tool for theory testing is still a controversial issue, and discussions about the weaknesses of such research designs have previously taken precedence over those about its strengths. The purpose of the paper is to examine and revive the approach of theory...... research paths....

  20. Final Report on Phase III Testing of Monosodium Titanate Adsorption Kinetics

    Energy Technology Data Exchange (ETDEWEB)

    Hobbs, D.T.

    1999-09-29

    This study consisted of a statistically designed set of tests to determine the extent and rate of adsorption of strontium, plutonium, uranium, and neptunium as a function of temperature, monosodium titanate (MST) concentration, and concentrations of sodium, strontium, plutonium, uranium, and neptunium.

  1. Radical model of arsenic(III) toxicity: theoretical and EPR spin trapping studies.

    Science.gov (United States)

    Zamora, Pedro L; Rockenbauer, Antal; Villamena, Frederick A

    2014-05-19

    Arsenic is one of the most environmentally significant pollutants and a great global health concern. Although a growing body of evidence suggests that reactive oxygen species (ROS) mediate the mechanism of arsenic toxicity, the exact mechanism remains elusive. In this study, we examine the capacity of trivalent arsenic species arsenous acid (iAs(III)), monomethylarsonous acid (MMA(III)), and dimethylarsinous acid (DMA(III)) to generate ROS through a theoretical analysis of their structures, redox properties, and their reactivities to various ROS using a density functional theory (DFT) approach at the B3LYP/6-31+G**//B3LYP/6-31G* level of theory and by employing electron paramagnetic resonance (EPR) spin trapping studies using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as a spin trap. Results show that the oxidized forms (As(IV)) are structurally more stable compared to the reduced forms (As(II)) that impart elongated As-O bonds leading to the formation of As(III) and hydroxide anion. Enthalpies of one-electron reduction and oxidation indicate that increasing the degree of methylation makes it harder for As(III) to be reduced but easier to be oxidized. The order of increasing favorability for arsenical activation by ROS is O2 redox pathways with concomitant generation of radicals. This is followed by MMA(III) and by iAs(III) being the least favorable. Spin trapping studies showed a higher propensity for methylated arsenicals to generate radicals than iAs(III) upon treatment with H2O2. However, in the presence of Fe(II,III), all showed radical generation where MMA(III) gave predominantly C-centered adducts, while acidified iAs (III) and DMA(III) gave primarily HO-adducts, and their formation was affected in the presence of SOD suggesting a As(III)-OO/OOH radical intermediate. Therefore, our results suggest a basis for the increased redox activity of methylated arsenicals that can be applied to the observed trends in arsenic methylation and toxicity in biological systems.

  2. Case Study: Testing with Case Studies

    Science.gov (United States)

    Herreid, Clyde Freeman

    2015-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses using case studies to test for knowledge or lessons learned.

  3. Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.

    Science.gov (United States)

    Emile, Jean-François; Julié, Catherine; Le Malicot, Karine; Lepage, Come; Tabernero, Josep; Mini, Enrico; Folprecht, Gunnar; Van Laethem, Jean-Luc; Dimet, Stéphanie; Boulagnon-Rombi, Camille; Allard, Marc-Antoine; Penault-Llorca, Frédérique; Bennouna, Jaafar; Laurent-Puig, Pierre; Taieb, Julien

    2017-09-01

    The prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use. According to National Institutes of Health criteria, we designed a prospective validation of this biomarker in patients included in the PETACC8 phase III study. Primary objective was to compare percentage of patients alive and without recurrence at 2 years in patients with high versus low LI (#NCT02364024). Associations of LI with patient recurrence and survival were analysed, and multivariable models were adjusted for treatment and relevant factors. Automated testing of LI was performed on virtual slides without access to clinical data. Among the 1220 CC patients enrolled, LI was high, low and not evaluable in 241 (19.8%), 790 (64.8%) and 189 (15.5%), respectively. Primary objective was met with a 2-year recurrence rate of 14.4% versus 21.1% in patients with high and low LI, respectively (p = 0.02). Patients with high LI also had better disease free survival (DFS) and overall survival (OS). Tumour stage, grade, RAS status and BRAF status were with LI the only prognostic markers in multivariable analysis for OS. Subgroup analyses revealed that high LI had better DFS and OS in mismatch repair (MMR) proficient patients, and in patients without RAS mutation, but not in MMR deficient and RAS mutated patients. Although this is the first validation with high level of evidence (IIB) of the prognostic value of a LI test in colon cancers, it still needs to be confirmed in independent series of colon cancer patients. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. NEW THIO S2- ADDUCTS WITH ANTIMONY (III AND V HALIDE: SYNTHESIS AND INFRARED STUDY

    Directory of Open Access Journals (Sweden)

    HASSAN ALLOUCH

    2013-12-01

    Full Text Available Five new S2- adducts with SbIII and SbV halides have been synthesized and studied by infrared. Discrete structures have been suggested, the environment around the antimony being tetrahedral, trigonal bipyramidal or octahedral.

  5. 77 FR 11651 - Hybrid III 10-Year-Old Child Test Dummy

    Science.gov (United States)

    2012-02-27

    ... Shoulder and Neck Chrysler\\16\\ and Graco were concerned that spikes or ``noise'' is present in the signal... provides resistance to the z-axis pivoting. Compared to Hybrid III adult dummies, the shoulder design of... through the entire spine, which appears as noise in the signals of nearby sensors. As described earlier...

  6. Fractographic study of epoxy fractured under mode I loading and mixed mode I/III loading

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Fei [ORNL; Wang, Jy-An John [ORNL; Bertelsen, Williams D. [Gougeon Brothers, Inc.

    2011-01-01

    Fiber reinforced polymeric composite materials are widely used in structural components such as wind turbine blades, which are typically subject to complicated loading conditions. Thus, material response under mixed mode loading is of great significance to the reliability of these structures. Epoxy is a thermosetting polymer that is currently used in manufacturing wind turbine blades. The fracture behavior of epoxy is relevant to the mechanical integrity of the wind turbine composite materials. In this study, a novel fracture testing methodology, the spiral notch torsion test (SNTT), was applied to study the fracture behavior of an epoxy material. SNTT samples were tested using either monotonic loading or cyclic loading, while both mode I and mixed mode I/III loading conditions were used. Fractographic examination indicated the epoxy samples included in this study were prone to mode I failure even when the samples were subject to mixed mode loading. Different fatigue precracks were observed on mode I and mixed mode samples, i.e. precracks appeared as a uniform band under mode I loading, and a semi-ellipse under mixed mode loading. Fracture toughness was also estimated using quantitative fractography.

  7. DECOVALEX III PROJECT. Modelling of FEBEX In-Situ Test. Task1 Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, E.E.; Alcoverro, J. [Univ. Politecnica de Catalunya, Barcelona (Spain)] (comps.)

    2005-02-15

    Task 1 of DECOVALEX III was conceived as a benchmark exercise supported by all field and laboratory data generated during the performance of the FEBEX experiment designed to study thermo-hydro-mechanical and thermo-hydro-geochemical processes of the buffer and rock in the near field. The task was defined as a series of three successive blind prediction exercises (Parts A, B and C), which cover the behaviour of both the rock and bentonite barrier. Research teams participating in the FEBEX task were given, for each of the three parts, a set of field and laboratory data theoretically sufficient to generate a proper model and were asked to submit predictions, at given locations and time, for some of the measured variables. The merits and limitations of different modeling approaches were therefore established. The teams could perform additional calculations, once the actual 'solution' was disclosed. Final calculations represented the best approximation that a given team could provide, always within the general time constraints imposed by the General DECOVALEX III Organization. This report presents the works performed for Task 1. It contains the case definitions and evaluations of modelling results for Part A, B and C, and the overall evaluation of the works performed. The report is completed by a CD-ROM containing a set of final reports provided by the modeling teams participating in each of the three parts defined. These reports provide the necessary details to better understand the nature of the blind or final predictions included in this report. The report closes with a set of conclusions, which provides a summary of the main findings and highlights the lessons learned, some of which were summarized below. The best predictions of the water inflow into the excavated tunnel are found when the hydro geological model is properly calibrated on the basis of other known flow measurements in the same area. The particular idealization of the rock mass (equivalent

  8. THE STUDY OF THE BIOLOGICAL ACTIVITY OF SOME COBALT(III DIOXIMATES WITH FLUORINE CONTAINING ANIONS

    Directory of Open Access Journals (Sweden)

    Eduard Coropceanu

    2008-12-01

    Full Text Available It was elaborated the methodology of synthesizing a series of new dioximates of Co(III with the general formula [Co(DioxH2(L2]X⋅nH2O, where DioxH – the dioxime anione: dimethylglyoxime (DH2, 1,2-cyclohexanedionedioxime (NioxH2; L - thiocarbamide (Thio, pyridine (Py, aniline (An, sulphanilamide (Sam;X - [BF4]-, [ZrF6]2-, [TiF6]2-, whose structures have been studied with the help of contemporary physical methods: spectroscopy IR, UV-Vis, RMN 1H, 19F, X-ray analysis. There were elaborated optimal conditions of using cobalt dioximates with fluorine in order to intensify the biosynthesis of amylases and lipases by Aspergillus and Rhizopus strains, respectively. The tested compounds increase the lipolytic activity of Rhizopus arrhisus micromycetes.

  9. Synthesis, Physicochemical Properties, and Antimicrobial Studies of Iron (III Complexes of Ciprofloxacin, Cloxacillin, and Amoxicillin

    Directory of Open Access Journals (Sweden)

    Fabian I. Eze

    2014-01-01

    Full Text Available Iron (III complexes of ciprofloxacin, amoxicillin, and cloxacillin were synthesized and their aqueous solubility profiles, relative stabilities, and antimicrobial properties were evaluated. The complexes showed improved aqueous solubility when compared to the corresponding ligands. Relative thermal and acid stabilities were determined spectrophotometrically and the results showed that the complexes have enhanced thermal and acid stabilities when compared to the pure ligands. Antimicrobial studies showed that the complexes have decreased activities against most of the tested microorganisms. Ciprofloxacin complex, however, showed almost the same activity as the corresponding ligand. Job’s method of continuous variation suggested 1 : 2 metals to ligand stoichiometry for ciprofloxacin complex but 1 : 1 for cloxacillin complex.

  10. Synthesis, Physicochemical Properties, and Antimicrobial Studies of Iron (III) Complexes of Ciprofloxacin, Cloxacillin, and Amoxicillin.

    Science.gov (United States)

    Eze, Fabian I; Ajali, Uzoechi; Ukoha, Pius O

    2014-01-01

    Iron (III) complexes of ciprofloxacin, amoxicillin, and cloxacillin were synthesized and their aqueous solubility profiles, relative stabilities, and antimicrobial properties were evaluated. The complexes showed improved aqueous solubility when compared to the corresponding ligands. Relative thermal and acid stabilities were determined spectrophotometrically and the results showed that the complexes have enhanced thermal and acid stabilities when compared to the pure ligands. Antimicrobial studies showed that the complexes have decreased activities against most of the tested microorganisms. Ciprofloxacin complex, however, showed almost the same activity as the corresponding ligand. Job's method of continuous variation suggested 1 : 2 metals to ligand stoichiometry for ciprofloxacin complex but 1 : 1 for cloxacillin complex.

  11. Synthesis, spectroscopic characterization and antibacterial studies of lanthanide(III) Schiff base complexes containing N, O donor atoms

    Science.gov (United States)

    Lekha, L.; Raja, K. Kanmani; Rajagopal, G.; Easwaramoorthy, D.

    2014-01-01

    A series of six Ln(III) Schiff base complexes, Pr(III), Sm(III), Gd(III), Tb(III), Er(III) and Yb(III), were synthesized using sodium salt of Schiff base, 2-[(5-bromo-2-hydroxy-benzylidene)-amino]-3-hydroxy-propionic acid, derived from L-serine and 5-bromosalicylaldehyde. These complexes having general formula [Ln(L)(NO3)2(H2O)]·NO3 were characterized by elemental analysis, conductivity measurements, UV-Vis, FT-IR, mass spectrometry and fluorescence studies. Elemental analysis and conductivity measurements suggest the complexes have a 1:1 stoichiometry. From the spectral studies it has been concluded that Ln(III) complexes display eight coordination. The Schiff base and its Ln(III) metal complexes have also been screened for their antibacterial activities by Agar diffusion method.

  12. Qualification of TRACE v5 code against fast cooldown transient in the PKL-III integral test facility

    Energy Technology Data Exchange (ETDEWEB)

    Coscarelli, E.; Del Nevo, A.; D' Auria, F., E-mail: e.coscarelli@ing.unipi.it, E-mail: delnevo@hotmail.com, E-mail: f.dauria@ing.unipi.it [Univ, of Pisa San Piero a Grado Nuclear Research Group (GRNSPG) (Italy)

    2011-07-01

    The present paper deals with the analytical study of the PKL experiment G3.1 performed using the TRACE code (version 5.0 patch 1). The G-series consists of eight tests carried out at the PKL-III facility located in Germany. In particular, the test G3.1 simulates a fast cooldown transient, namely, a main steam line break. The break in the steam line, causes a rapid depressurization of the affected steam generator. This leads to a strong asymmetry caused by an increase of the heat transfer from the primary to the secondary side that induces a fast cooldown transient on the primary side affected loop. The asymmetric overcooling effect requires an assessment of the reactor pressure vessel integrity considering PTS (pressurized thermal shock) and an assessment of potential recriticality following entrainment of colder water into the core area. The analytical investigation is performed by developing a complete TRACE input model of the PKL integral test facility, including 3-dimensional components to simulate the thermalhydraulic behavior of the fluid in the reactor vessel (RPV). The aim of this work is the qualification of the heat transfer capabilities of the TRACE code from primary to secondary side in the intact and affected steam generators (SGs) during the rapid depressurization and the boil-off in the affected SG against experimental data. The accuracy of the calculation is evaluated by qualitative and quantitative analysis. The quantification of the accuracy is performed using the Fast Fourier Transform Base Method (FFTBM) developed at University of Pisa. The tool provides an integral representation of the accuracy quantification in the frequency domain. (author)

  13. Expression of type I and type III collagens in oral submucous fibrosis: An immunohistochemical study

    Directory of Open Access Journals (Sweden)

    Venkatesh V Kamath

    2015-01-01

    Full Text Available Background: Oral submucous fibrosis (OSMF is a potentially malignant collagen - metabolic disorder linked to consumption of betel quid and areca nut. The deposition of collagen and its major subtypes have been the subject of intense scrutiny in the etiopathogenesis of the disorder. Aims and Objectives: The present study was planned to immunohistochemically identify the expression of collagens I and III (COL I and III in different grades of OSF and compare it with normal oral mucosa and scar tissue. Materials and Methods: Archival paraffin sections of 72 cases of various grades of OSMF, ten cases of normal mucosa as controls and four cases of scar tissue were stained with antibodies to COL I and III (BioGenex Laboratories, CA, USA to evaluate the collagen subtypes on paraffin sections. The expression was quantified by image analysis software (Jenoptik Optical System, ProgRes ® Capture Pro, version 2.8.8 and statistically analyzed. Results: COL I and III stained all the tissues ubiquitously. COL I was more in ratio and quantity in all the grades of OSMF, normal mucosa, and scar tissue. The proportion of COL I to COL III seemed to increase with progressive grades of OSF. Interestingly, during the process of fibrosis COL III seems to be deposited earlier and gradually replaced by COL I resulting in a skewed ratio vis a vis normal oral mucosa and scar tissue. Conclusions: COL I expression was found to be proportionate with advancing grades of OSF while COL III expression increased in Grade I but subsequently decreased as severity of OSF increased. The increase in COL I at the expense of COL III showed a similar pattern in the submucosa while in the deeper muscle only Grade III cases reflected the trend. While all cases of OSF revealed excessive expression in comparison with normal oral mucosa, the comparison with scar tissue was variable.

  14. Immunochemical studies of Lolium perenne (rye grass) pollen allergens, Lol p I, II, and III.

    Science.gov (United States)

    Ansari, A A; Kihara, T K; Marsh, D G

    1987-12-15

    It was reported earlier that human immune responses to three perennial rye grass (Lolium perenne) pollen allergens, Lol p I, II, and III, are associated with histocompatibility leukocyte antigen (HLA)-DR3. Rye-allergic people are often concordantly sensitive to all three of these allergens. Since earlier studies suggested that these antigens are non-cross-reactive, their immunologic relatedness by double antibody radioimmunoassay (DARIA) was studied in order to understand further the immunochemical basis for the concordant recognition of the three allergens. Direct binding DARIA studies were performed with human sera from 189 allergic subjects. Inhibition DARIA studies were carried out with 17 human sera from grass-allergic patients who were on grass immunotherapy, one goat anti-serum, and six rabbit antisera. None of the sera detected any significant degree of two-way cross-reactivity between Lol p I and II, or between Lol p I and III. However, the degree of two-way cross-reactivity between Lol p II and III exhibited by individual human and animal antisera varied between undetectable and 100%. In general, the degree of cross-reactivity between Lol p II and III was higher among human sera than among animal sera. Taken together with earlier findings that antibody responses to Lol p I, II and III are associated with HLA-HDR3, and that most Lol p II and III responders are also Lol p I responders, but not vice versa, our present results suggest the following: the HLA-DR3-encoded Ia molecule recognizes a similar immunodominant Ia recognition site (agretope) shared between Lol p I and Lol p II and/or III; in addition, Lol p I appears to contain unique Ia recognition site(s) not present in Lol p II and III. However, further epitope analyses are required to investigate these possibilities.

  15. The Influences of Arm Resist Motion on a CAR Crash Test Using Hybrid III Dummy with Human-Like Arm

    Science.gov (United States)

    Kim, Yongchul; Youm, Youngil; Bae, Hanil; Choi, Hyeonki

    Safety of the occupant during the crash is very essential design element. Many researches have been investigated in reducing the fatal injury of occupant. They are focusing on the development of a dummy in order to obtain the real human-like motion. However, they have not considered the arm resist motion during the car accident. In this study, we would like to suggest the importance of the reactive force of the arm in a car crash. The influences of reactive force acting on the human upper extremity were investigated using the impedance experimental method with lumped mass model of hand system and a Hybrid III dummy with human-like arm. Impedance parameters (e.g. inertia, spring constant and damping coefficient) of the elbow joint in maximum activation level were measured by free oscillation test using single axis robot. The results showed that without seat belt, the reactive force of human arm reduced the head, chest, and femur injury, and the flexion moment of the neck is higher than that of the conventional dummy.

  16. A spectrophotometric study of Am(III) complexation with nitrate in aqueous solution at elevated temperatures.

    Science.gov (United States)

    Tian, Guoxin; Shuh, David K

    2014-10-21

    The complexation of americium(iii) with nitrate was studied at temperatures from 10 to 85 °C in 1 M HNO3-HClO4 by spectrophotometry. The 1 : 1 complex species, AmNO3(2+), was identified and the stability constants were calculated from the absorption spectra recorded for titrations at several temperatures. Specific ion interaction theory (SIT) was used for ionic strength corrections to obtain the stability constants of AmNO3(2+) at infinite dilution and variable temperatures. The absorption spectra of Am(iii) in diluted HClO4 were also reviewed, and the molar absorptivity of Am(iii) at around 503 nm and 813 nm was re-calibrated by titrations with standardized DTPA solutions to determine the concentration of Am(iii).

  17. Geosorption of As(III) from aqueous solution by red clays: kinetic studies.

    Science.gov (United States)

    Rivera-Hernández, José R; Green-Ruiz, Carlos

    2014-05-01

    The geosorption of As(III) on red clays from aqueous solution under different environmental conditions (i.e. initial concentration, pH and temperature) was studied. This process reached its equilibrium quickly (clays at 0.1 mg As(III) L(-1) was 10, while for 10 mg As(III) L(-1) was 4. There wasn't a significant effect of temperature on the As(III) adsorption. The kinetic pseudo-second order and the isothermal Langmuir were the models that best described the experimental data, suggesting an adsorption process in multistep. Likewise, there are not interactions between neighbor active sites on the red clay surface.

  18. Effects of Class III malocclusion on young male adults' vocal tract development: a pilot study.

    Science.gov (United States)

    Xue, Steve An; Lam, Connie W-Y; Whitehill, Tara L; Samman, Nabil

    2011-03-01

    To compare the vocal tract configuration between male speakers with Class III malocclusion and their normally developing counterparts and to investigate the concomitant acoustic changes caused by the alterations in vocal tract configuration. Eight young male patients with Class III malocclusion and 8 normally developing counterparts participated in this study. Acoustic reflection technology was used to measure vocal tract dimensions in the 2 groups. A continuous speech sample and 4 sustained vowels (/a/, /æ/, /i/, and /u/) were recorded from each participant to obtain the fundamental frequency and the first 3 formant frequencies (F1, F2, and F3). The results showed significantly greater oral length and oral volume for young male patients with Class III malocclusion than their cohorts. The F1 of vowel /u/ was found to be significantly higher in male patients with Class III malocclusion than their cohorts. The vowel space of the 4 recorded vowels was reduced and the F1-F2 formant map for /u/ was relatively more scattered in male patients with Class III malocclusion than in the control speakers. This study has provided preliminary information on the effects of Class III malocclusion on vocal tract configuration and concomitant acoustic changes in young male patients. Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  19. Dual-mode EPR study of Mn(III) salen and the Mn(III) salen-catalyzed epoxidation of cis-beta-methylstyrene.

    Science.gov (United States)

    Campbell, K A; Lashley, M R; Wyatt, J K; Nantz, M H; Britt, R D

    2001-06-20

    Dual-mode electron paramagnetic resonance (EPR), in which an oscillating magnetic field is alternately applied parallel or perpendicular to the static magnetic field, is a valuable technique for studying both half-integer and integer electron spin systems and is particularly useful for studying transition metals involved in redox chemistry. We have applied this technique to the characterization of the Mn(III) salen (salen = N,N'-ethylene bis(salicylideneaminato)) complex [(R,R)-(-)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III)], with an S = 2 integer electron spin system. Furthermore, we have used dual-mode EPR to study the Mn salen complex during the Mn(III) salen-catalyzed epoxidation of cis-beta-methylstyrene. Our study shows that the additives N-methylmorpholine N-oxide (NMO) and 4-phenylpyridine-N-oxide (4-PPNO), which are used to improve epoxidation yields and enantioselection, bind to the Mn(III) center prior to the epoxidation reaction, as evidenced by the alteration of the Mn(III) parallel mode EPR signal. With these additives as ligands, the axial zero-field splitting values and (55)Mn hyperfine splitting of the parallel mode signal are indicative of an axially elongated octahedral geometry about the Mn(III) center. Since the dual-mode EPR technique allows the observation of both integer and half-integer electron spin systems, Mn oxidation states of II, III, IV, and potentially V can be observed in the same sample as well as any radical intermediates or Mn(III,IV) dinuclear clusters formed during the Mn(III) salen-catalyzed epoxidation reaction. Indeed, our study revealed the formation of a Mn(III,IV) dinuclear cluster in direct correlation with expoxide formation. In addition to showing the possible reaction intermediates, dual-mode EPR offers insight into the mechanism of catalyst degradation and formation of unwanted byproducts. The dual-mode technique may therefore prove valuable for elucidating the mechanism of Mn(III

  20. Adsorption Behaviour of La(III) and Eu(III) Ions from Aqueous Solutions by Hydroxyapatite: Kinetic, Isotherm, and Thermodynamic Studies

    OpenAIRE

    Granados-Correa, F.; Vilchis-Granados, J.; Jiménez-Reyes, M.; Quiroz-Granados, L. A.

    2013-01-01

    The hydroxyapatite was successfully synthesized, characterized, and used as an alternative low-cost adsorbent material to study the adsorption behavior of La(III) and Eu(III) ions from nitrate aqueous solutions as a function of contact time, initial metal ion concentration, pH, and temperature by using a bath technique. The kinetic data correspond very well to the pseudo-second-order equation, and in both cases the uptake was affected by intraparticle diffusion. Isotherm adsorption data were ...

  1. Noncontact laser photothermal keratoplasty. III: Histological study in animal eyes.

    Science.gov (United States)

    Ren, Q; Simon, G; Parel, J M

    1994-01-01

    Laser photothermal keratoplasty has been studied as a potential refractive procedure. The purpose of this study is to investigate the histological response to various laser treatments including geometrical patterns, radiant exposure levels, and pulse numbers. A noncontact laser photothermal keratoplasty system was used in this study. Epithelial and endothelial response to the laser photothermal keratoplasty annulus treatment pattern were studied on an owl monkey model with a 5-millimeter annulus ring pattern, 8 J/cm2, 25 consecutive pulses at 1 Hz. Epithelial and endothelial response to the laser photothermal keratoplasty spot pattern were then studied and compared on cat and rabbit models for safety monitoring. One pulse and five consecutive pulses of eight different radiant exposures (5.00 J/cm2 to 18.01 J/cm2) were applied on each cornea. A cadaver eye model was used to study the collagen shrinkage induced by the laser spot treatment following the same protocol as the cat and rabbit model. Finally, the biological healing response to the laser photothermal keratoplasty treatment with the optimal laser parameters obtained in our experiment was studied on the cat model. Five cats were treated by the laser photothermal keratoplasty procedure with eight spots on a 3-millimeter ring, 15.6 J/cm2, and 1 pulse. Epithelial and endothelial damage were observed after annulus treatment on an owl monkey's cornea at 8 J/cm2, 25 pulses, and after spot treatment on cat and rabbit corneas at 18.01 J/cm2, five pulses. No endothelial damage was observed on cat corneas for the single pulse treatment at 18.01 J/cm2. For the tissue shrinkage study, no laser photothermal keratoplasty lesion could be detected for a radiant exposure setting below 10.26 J/cm2. Histological cross-sections showed that the five-pulse treatment reached the endothelial layer at a radiant exposure of 13.4 J/cm2, while no single pulse treatment reached the endothelium for the radiant exposure range (5 J/cm2 to

  2. Model validation studies of solar systems, Phase III. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, L.J.; Winn, C.B.

    1978-12-01

    Results obtained from a validation study of the TRNSYS, SIMSHAC, and SOLCOST solar system simulation and design are presented. Also included are comparisons between the FCHART and SOLCOST solar system design programs and some changes that were made to the SOLCOST program. Finally, results obtained from the analysis of several solar radiation models are presented. Separate abstracts were prepared for ten papers.

  3. Aqueous complexation of citrate with neodymium(III) and americium(III): a study by potentiometry, absorption spectrophotometry, microcalorimetry, and XAFS.

    Science.gov (United States)

    Brown, M Alex; Kropf, A Jeremy; Paulenova, Alena; Gelis, Artem V

    2014-05-07

    The aqueous complexation of Nd(III) and Am(III) with anions of citrate was studied by potentiometry, absorption spectrophotometry, microcalorimetry, and X-ray absorption fine structure (XAFS). Using potentiometric titration data fitting the metal-ligand (L) complexes that were identified for Nd(III) were NdHL, NdL, NdHL2, and NdL2; a review of trivalent metal-citrate complexes is also included. Stability constants for these complexes were calculated from potentiometric and spectrophotometric titrations. Microcalorimetric results concluded that the entropy term of complex formation is much more dominant than the enthalpy. XAFS results showed a dependence in the Debye-Waller factor that indicated Nd(iii)-citrate complexation over the pH range of 1.56-6.12.

  4. [Study of anterior alveolar bone thickness in skeletal class III malocclusion patients with orthognathic surgery].

    Science.gov (United States)

    Zhang, Jie; Li, Xiao-tong

    2016-02-18

    To investigate the compensation of the anterior alveolar bone thickness in skeletal class III patients treated with orthodontic-surgical treatment. The samples consisted of 54 skeletal class III patients treated with orthodontic-surgical treatment. Lateral cephalograms were taken before treatment. Descriptive statistics were calculated for corresponding variables, and the differences between the samples and the norms from Peking University normal occlusion sample library were assessed by independent-sample t test. Correlation analyses were performed to find associations between skeletal characteristics and anterior alveolar bone thickness. According to skeletal anteroposterior discrepancy/vertical type (ANB, criteria=-4°; SN-MP, criteria=37.7°), the samples were allocated into group A (severe anteroposterior discrepancy/hypodivergent vertical type, n=11), group B (moderate anteroposterior discrepancy/hypodivergent vertical type, n=16), group C (severe anteroposterior discrepancy/hyperdivergent vertical type, n=14), and group D (moderate anteroposterior discrepancy/hyperdivergent vertical type, n=13),and one-way ANOVA with SNK multiple comparison test were performed. The anterior alveolar bone thickness of the skeletal class III patients were thinner compared with norm values (Pclass III patients are thinner compared with normal occlusion. Different skeletal anteroposterior discrepancy/vertical type results in differences in the anterior alveolar bone thickness, so decompensation should be treated differently and carefully.

  5. Electrochemiluminescence Study of Europium (III Complex with Coumarin3-Carboxylic Acid

    Directory of Open Access Journals (Sweden)

    Stefan Lis

    2008-01-01

    Full Text Available The europium (III complex of coumarin-3-carboxylic acid (C3CA has been prepared and characterized on the basis of elemental analysis, IR, and emission (photoluminescence and electrochemiluminescence spectroscopy. The synthesised complex having a formula Eu(C3CA2(NO3(H2O2 was photophysically characterized in solution and in the solid state. Electrochemiluminescence, ECL, of the system containing the Eu(III/C3CA complex was studied using an oxide-covered aluminium electrode. The goal of these studies was to show the possibility of the use of electrochemical excitation of the Eu(III ion in aqueous solution for emission generation. The generated ECL emission was very weak, and therefore its measurements and spectral analysis were carried out with the use of cut-off filters method. The studies proved a predominate role of the ligand-to-metal energy transfer (LMET in the generated ECL.

  6. Adsorption Behaviour of La(III and Eu(III Ions from Aqueous Solutions by Hydroxyapatite: Kinetic, Isotherm, and Thermodynamic Studies

    Directory of Open Access Journals (Sweden)

    F. Granados-Correa

    2013-01-01

    Full Text Available The hydroxyapatite was successfully synthesized, characterized, and used as an alternative low-cost adsorbent material to study the adsorption behavior of La(III and Eu(III ions from nitrate aqueous solutions as a function of contact time, initial metal ion concentration, pH, and temperature by using a bath technique. The kinetic data correspond very well to the pseudo-second-order equation, and in both cases the uptake was affected by intraparticle diffusion. Isotherm adsorption data were well fitted by the Freundlich model equation with 1/n>1, indicating a multilayer and cooperative-type adsorption. Thermodynamic parameters for the adsorption systems were determinated at 293, 303, 313, and 323 K. These parameters show that adsorptions of La(III and Eu(III ions on hydroxyapatite are endothermic and spontaneous processes. The adsorption was found to follow the order Eu(III > La(III and is dependent on ion concentration, pH, and temperature.

  7. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN--DREAMS III: Study design and research methodology

    Directory of Open Access Journals (Sweden)

    Sahu Chinmaya

    2011-03-01

    Full Text Available Abstract Background To describe the methodology of the Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study III, an ongoing epidemiological study to estimate the prevalence of Diabetes and Diabetic Retinopathy in rural population of Kanchipuram and Thiravallur districts of Tamil Nadu, India and to elucidate the clinical, anthropometric, biochemical and genetic risk factors associated with diabetic retinopathy in this rural population. Methods Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study III will be a mobile van based epidemiological study; 11,760 participants aged ≥ 40 years will be recruited from the study areas. Eligible subjects will undergo blood sugar estimation to diagnose Diabetes. Oral Glucose Tolerance Test will be done to conform diabetes. All subjects with diabetes will undergo complete information of knowledge, aptitude and practice of diabetes and diabetic retinopathy, Diet questionnaire, demographic data, socioeconomic status, physical activity, anthropometric measurements, and risk of sleep apnoea. A detailed medical and ocular history, a comprehensive eye examination including refraction, slit lamp biomicroscopy examination, indirect ophthalmoscopy, slit lamp biomicroscopy, digital stereo fundus photography and ultrasound of eye will be done in the mobile van. Blood will be collected for biochemical investigations including blood hemoglobin, glycosylated hemoglobin, lipid profile, urea and creatinine, genetic study. Urine will be collected for microalbuminuria. All fundus photographs will be graded at base hospital. Participants who need treatment will be sent to the base hospital. A computerized database is created for the records. Conclusion The study is expected to provide an estimate of the prevalence of Diabetes and Diabetic Retinopathy and also a better understanding of the genetic, anthropometric and socio-economic risk factors associated with Diabetic

  8. Spectrophotometric study of etodolac complexes with copper (II) and iron (III).

    Science.gov (United States)

    Amer, Sawsan M; El-Saharty, Yasser S; Metwally, Fadia H; Younes, Kareem M

    2005-01-01

    A rapid, simple, and selective method was developed for the determination of etodolac. The method depends on complexation of etodolac with copper (II) acetate and iron (III) chloride followed by extraction of complexes with dichloromethane and then measuring the extracted complexes spectrophotometrically at 684 and 385 nm in case of Cu (II) or Fe (III), respectively. Different factors affecting the reaction, such as pH, reagent concentration, and time, were studied. By use of Job's method of continuous variation, the molar ratio method, and elemental analysis, the stoichiometry of the reaction was found to be in the ratio of 1:2 and 1:3, metal:drug in the case of Cu (II) and Fe (III), respectively. The method obeys Beer's law in a concentration range of 2.00-9.00 and 0.50-2.00 mg/mL in case of Cu (II) and Fe (III), respectively. The stability of the complexes formed was also studied, and the reaction products were isolated for further investigation. The complexes have apparent molar absorptivities of about 32.14 +/- 0.97 and 168.32 +/- 1.12 for Cu (II) and Fe (III), respectively. The suggested procedures were successfully applied to the analysis of pure etodolac and its pharmaceutical formulations. The validity of the procedures was further ascertained by the method of standard additions, and the results were compared with other reported spectrophotometric methods and showed no significant difference in accuracy and precision.

  9. Synthesis and characterization of a heptadentate (N4O3 Schiff base ligand and associated La(III, Sm(III and Gd(III complexes, and a theoretical study

    Directory of Open Access Journals (Sweden)

    Sadegh Salehzadeh

    2010-04-01

    Full Text Available A new symmetrical potentially heptadentate (N4O3 Schiff base ligand {N[CH2CH2CH2N=CH(2-OH-5-BrC6H3]3} (H3L6 and associated neutral Gd(III, La(III and Sm(III complexes, were synthesized. The new compounds were characterized by IR spectroscopy, elemental analysis and mass spectrometry in all cases and in the case of ligand also with NMR spectroscopy. The relative capability of H3L6 to encapsulate a lanthanide ion, herein La(III, has been theoretically studied by ab initio restricted Hartree-Fock (RHF and DFT (B3LYP methods. The calculation confirmed that the H3L6 ligand can effectively encapsulate a lanthanide ion and enforce a seven-coordinate geometry.

  10. A radiographic study of temporomandibular joints in skeletal class III malocclusion

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Eun; Kim, Kae Duk [Chosun University College of Medicine, Kwangju (Korea, Republic of)

    2003-06-15

    To investigate the differences between the position of the mandibular condyles in temporomandibular joints of patients presenting with normal occlusion and skeletal class III malocclusion. Forty-two subjects with normal occlusion and thirty-seven subjects exhibiting skeletal class III malocclusion prior to orthodontic treatment were included in the study. Transcranial radiographs of each subject were taken at centric occlusion and 1 inch mouth opening. The positional relationship between the mandibular condyles with articular fossae and articular eminences at two positional states were evaluated and analyzed statistically. The mandibular condyles of the skeletal class III malocclusion group were found to be located more anteriorly from the center of the articular fossae compared to the normal occlusion group in centric occlusion. The mandibular condyles of the skeletal Class III malocclusion group were located more superiorly from the middle of articular height than those of the normal occlusion group in centric occlusion. However, these differences were not statistically significant. At 1 inch mouth opening, the mandibular condyles of the skeletal class III malocclusion group were placed more posteriorly from the articular eminences than those of the normal occlusion group. The mean angle of the articular eminence posterior slope were 56.51 .deg. {+-} 6.29 .deg. in the normal occlusion group and 60.37 .deg. {+-} 6.26 .deg. in the skeletal Class III malocclusion group. The mandibular condyles of the skeletal Class III malocclusion group were placed more anteriorly at centric occlusion and more posteriorly at 1 inch mouth opening when compared with those of the normal occlusion group.

  11. Study of Ascorbic Acid as Iron(III Reducing Agent for Spectrophotometric Iron Speciation

    Directory of Open Access Journals (Sweden)

    Antesar Elmagirbi

    2012-10-01

    Full Text Available The study of ascorbic acid as a reducing agent for iron(III has been investigated in order to obtain an alternative carcinogenic reducing agent, hydroxylamine, used in spectrophotometric standard method based on the formation of a red-orange complex of Fe(II-o-phenanthroline. The study was optimised with regards to ascorbic acid concentration as well as pH solution. The results showed that ascorbic acid showed maximum capacity as reducing agent of iron(III under concentration of 4.46.10-4 M and pH solution of 1-4.Under these conditions, ascorbic acid reduced iron(III proportionally and performed similarly to that of hydroxylamine.  The method gave result to linear calibration over the range of 0.2-2 mg/L withhigh accuracy of 97 % and relative standard deviation of less than 2 %. This method was successfully applied to assay iron speciation in water samples.

  12. 78 FR 55068 - Request for Information To Inform the Title III Evaluation and Research Studies Agenda

    Science.gov (United States)

    2013-09-09

    ... on Department studies related to the needs of English learners is posted on the following Web site... in English or in English and another language. e. Technology-based instructional strategies that... Request for Information To Inform the Title III Evaluation and Research Studies Agenda AGENCY: Office of...

  13. Systematic Study of a Family of Butterfly-Like {M2Ln2} Molecular Magnets (M = Mg(II), Mn(III), Co(II), Ni(II), and Cu(II); Ln = Y(III), Gd(III), Tb(III), Dy(III), Ho(III), and Er(III)).

    Science.gov (United States)

    Moreno Pineda, Eufemio; Chilton, Nicholas F; Tuna, Floriana; Winpenny, Richard E P; McInnes, Eric J L

    2015-06-15

    A family of 3d-4f [M(II)2Ln(III)2(μ3-OH)2(O2C(t)Bu)10](2-) "butterflies" (where M(II) = Mg, Co, Ni, and Cu; Ln(III) = Y, Gd, Tb, Dy, Ho, and Er) and [Mn(III)2Ln(III)2(μ3-O)2(O2C(t)Bu)10](2-) molecules (where Ln(III) = Y, Gd, Tb, Dy, Ho, and Er) has been synthesized and characterized through single-crystal X-ray diffraction, SQUID magnetometry, and ab initio calculations. All dysprosium- and some erbium-containing tetramers showed frequency-dependent maxima in the out-of-phase component of the susceptibility associated with slow relaxation of magnetization, and hence, they are single-molecule magnets (SMMs). AC susceptibility measurements have shown that the SMM behavior is entirely intrinsic to the Dy and Er sites and the magnitude of the energy barrier is influenced by the interactions between the 4f and the 3d metal. A trend is observed between the strength of the 3d-4f exchange interaction between and the maximum observed in the χ″M(T).

  14. Complexation and molecular modeling studies of europium(III)-gallic acid-amino acid complexes.

    Science.gov (United States)

    Taha, Mohamed; Khan, Imran; Coutinho, João A P

    2016-04-01

    With many metal-based drugs extensively used today in the treatment of cancer, attention has focused on the development of new coordination compounds with antitumor activity with europium(III) complexes recently introduced as novel anticancer drugs. The aim of this work is to design new Eu(III) complexes with gallic acid, an antioxida'nt phenolic compound. Gallic acid was chosen because it shows anticancer activity without harming health cells. As antioxidant, it helps to protect human cells against oxidative damage that implicated in DNA damage, cancer, and accelerated cell aging. In this work, the formation of binary and ternary complexes of Eu(III) with gallic acid, primary ligand, and amino acids alanine, leucine, isoleucine, and tryptophan was studied by glass electrode potentiometry in aqueous solution containing 0.1M NaNO3 at (298.2 ± 0.1) K. Their overall stability constants were evaluated and the concentration distributions of the complex species in solution were calculated. The protonation constants of gallic acid and amino acids were also determined at our experimental conditions and compared with those predicted by using conductor-like screening model for realistic solvation (COSMO-RS) model. The geometries of Eu(III)-gallic acid complexes were characterized by the density functional theory (DFT). The spectroscopic UV-visible and photoluminescence measurements are carried out to confirm the formation of Eu(III)-gallic acid complexes in aqueous solutions. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. 49 CFR 232.211 - Class III brake tests-trainline continuity inspection.

    Science.gov (United States)

    2010-10-01

    ...) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRAKE SYSTEM SAFETY STANDARDS FOR FREIGHT... performed on a train by a qualified person, as defined in § 232.5, to test the train brake system when the... have previously received a Class I brake test, have not been off air more than four hours, and the cars...

  16. Interactions of Eu(III) with biogenic CaCO{sub 3} studied with TRLFS

    Energy Technology Data Exchange (ETDEWEB)

    Johnstone, Erik V.; Schmidt, Moritz [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Div. Surface Processes; Cherkouk, Andrea [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Div. Biogeochemistry

    2016-07-01

    The interactions of Eu(III) with CaCO{sub 3} arising from biogenic origin was investigated by Time-Resolved Laser-Induced Fluorescence Spectroscopy (TRLFS). Biologically-induced precipitation via ureolysis was studied with the bacteria Sporosarcina pasteurii in the presence of Eu(III). Biomineralization occurred forming mixed phases of vaterite and calcite after one day that transformed over two weeks to pure calcite. Eu(III) was quantitatively removed from solution during mineral formation. TRLFS results show that after one day the Eu{sup 3+} is located in the vaterite phase. After one week, the Eu{sup 3+} was found primarily in the vaterite, despite calcite now being the predominant mineral, and a transition species was also formed. In the calcite two incorporated Eu{sup 3+} species were present: one substitutes at the Ca{sup 2+} site in the crystal lattice and the other is speculated to be associated with the organicmineral matrix.

  17. Quality assessment in in vivo NMR spectroscopy: III. Clinical test objects: design, construction, and solutions

    DEFF Research Database (Denmark)

    Leach, M.O.; Collins, D.J.; Keevil, S

    1995-01-01

    Based on the requirements of test protocols developed to evaluate clinical MRS single slice and volume localisation sequences, two clinical test objects, STO1 and STO2 have been developed. The properties of a range of potential construction materials have been assessed, demonstrating that the water....../Perspex interface produced minimum susceptibility effects. The design of the objects has been evaluated in trials on different magnetic resonance instruments, with size and loading being adjusted to allow use on currently available equipment. Appropriate test solutions for 31P and 1H measurements have been...

  18. Pengaruh Kesadaran dan Kepatuhan Wajib Pajak Terhadap Kinerja Perpajakan (Studi pada Kanwil Ditjen Pajak Jawa Timur III

    Directory of Open Access Journals (Sweden)

    Kariyoto

    2012-04-01

    Full Text Available Abstract: Effect of Awareness and Taxpayer Compliance Performace of Taxation. The aim of the study is to test the influence of compliance and taxpayer awareness on the performance of taxation. The population of this research is account representative that spread across the Regional Office of Directorate General of Taxation III, East Java, while samples taken is as many as 124 respondents. Analysis of research data uses SEM (structural equation modeling. The main findings of this study suggest that taxpayer compliance role in improving the performance of the tax proven to be effective. Awareness of the taxpayer has not provided tax benefits to increase performance.

  19. The MUSE Hubble Ultra Deep Field Survey. III. Testing photometric redshifts to 30th magnitude

    Science.gov (United States)

    Brinchmann, J.; Inami, H.; Bacon, R.; Contini, T.; Maseda, M.; Chevallard, J.; Bouché, N.; Boogaard, L.; Carollo, M.; Charlot, S.; Kollatschny, W.; Marino, R. A.; Pello, R.; Richard, J.; Schaye, J.; Verhamme, A.; Wisotzki, L.

    2017-11-01

    We tested the performance of photometric redshifts for galaxies in the Hubble Ultra Deep field down to 30th magnitude. We compared photometric redshift estimates from three spectral fitting codes from the literature (EAZY, BPZ and BEAGLE) to high quality redshifts for 1227 galaxies from the MUSE integral field spectrograph. All these codes can return photometric redshifts with bias |(zMUSE-pz) / (1 + zMUSE)| 3 they are systematically biased high by up to (zMUSE-pz) / (1 + zMUSE) = 0.05, an offset that can in part be explained by adjusting the amount of intergalactic absorption applied. In agreement with previous studies we find little difference in the performance of the different codes, but in contrast to those we find that adding extensive ground-based and IRAC photometry actually can worsen photo-z performance for faint galaxies. We find an outlier fraction, defined through |(zMUSE-pz) / (1 + zMUSE)| > 0.15, of 8% for BPZ and 10% for EAZY and BEAGLE, and show explicitly that this is a strong function of magnitude. While this outlier fraction is high relative to numbers presented in the literature for brighter galaxies, they are very comparable to literature results when the depth of the data is taken into account. Finally, we demonstrate that while a redshift might be of high confidence, the association of a spectrum to the photometric object can be very uncertain and lead to a contamination of a few percent in spectroscopic training samples that do not show up as catastrophic outliers, a problem that must be tackled in order to have sufficiently accurate photometric redshifts for future cosmological surveys.

  20. Strain Gage Loads Calibration Testing with Airbag Support for the Gulfstream III SubsoniC Research Aircraft Testbed (SCRAT)

    Science.gov (United States)

    Lokos, William; Miller, Eric; Hudson, Larry; Holguin, Andrew; Neufeld, David; Haraguchi, Ronnie

    2015-01-01

    This paper describes the design and conduct of the strain gage load calibration ground test of the SubsoniC Research Aircraft Testbed, Gulfstream III aircraft, and the subsequent data analysis and its results. The goal of this effort was to create and validate multi-gage load equations for shear force, bending moment, and torque for two wing measurement stations. For some of the testing the aircraft was supported by three air bags in order to isolate the wing structure from extraneous load inputs through the main landing gear. Thirty-two strain gage bridges were installed on the left wing. Hydraulic loads were applied to the wing lower surface through a total of 16 load zones. Some dead weight load cases were applied to the upper wing surface using shot bags. Maximum applied loads reached 54,000 pounds.

  1. Civilization III and Whole-Class Play in High School Social Studies

    Science.gov (United States)

    Lee, John K.; Probert, Jeffrey

    2010-01-01

    This study examined an 11th grade high school class as they played the game Civilization III. Over nine class sessions students played the game in support of other activities related to several predetermined and emergent topics in U. S. history. Gameplay was whole-class oriented and involved students taking turns at the computer controlling…

  2. XRD and optical microscopic studies of Co(III) complexes containing ...

    Indian Academy of Sciences (India)

    Unknown

    XRD and optical microscopic studies of Co(III) complexes. 343. Figure 1. Optical micrograph of the complexes: (a) [MLCl]2+, (b) [ML2]3+, (c) [ML2]3+, (d) [ML2]3+, containing acetone,. (e) [ML2T2]3+, (f) [MLTCl]2+ and (g) [MLA3]3+, M = Co(en)2.

  3. Rorschach and the WAIS-III after one and two years of psychotherapy O teste de Rorschach e a Escala WAIS-III após um e dois Anos de psicoterapia

    Directory of Open Access Journals (Sweden)

    Latife Yazigi

    2011-01-01

    Full Text Available This study aimed at identifying what aspects of personality are modified after one and two years of psychoanalytic psychotherapy in adults attending a free university healthcare service in São Paulo, Brazil. The instruments were the Rorschach and the WAIS-III tests which were administered before and after one and two years of treatment. The participants were 34 adult individuals, both genders. After one year of psychotherapy in the Rorschach method there was an increase in effective and adaptive interpersonal relationship, an enhancement in sensitiveness related to the capacity of modulating affect, the need for close contact as well as the arousal of feelings of discomfort associated with intensification of self-regard, and a decrease in narcissistic tendencies. As well as in WAIS-III, there was an increase in motivation, attention and speed processing.O estudo teve por objetivo identificar quais aspectos da personalidade são modificados após um e dois anos de psicoterapia psicanalítica em adultos atendidos em um serviço público de saúde mental de uma universidade em São Paulo, no Brasil. Os instrumentos utilizados foram o Rorschach e a Escala de Inteligência Wechsler para adultos (WAIS-III, os quais foram administrados antes e após um e dois anos de tratamento. Os participantes foram 34 indivíduos adultos, de ambos os sexos. No Rorschach, após um ano de psicoterapia, ocorreu melhora da relação interpessoal adaptada e efetiva, melhora na sensibilidade relacionada à capacidade de modular afeto e da necessidade de contato mais próximo, e surgimento de sentimentos de desconforto associados à intensificação de auto-observação e diminuição de tendências narcisistas. No WAIS-III houve aumento de motivação, melhora atencional e de velocidade de processamento.

  4. MELCOR analyses of NUPEC`s large-scale hydrogen mixing test-III

    Energy Technology Data Exchange (ETDEWEB)

    Tezuka, Hiroko [Nuclear Power Engineering Corp., Tokoyo (Japan); Ezzidi, A. [Computer Software Development Co., Ltd., Tokyo (Japan)

    1996-12-31

    The Nuclear Power Engineering Corporation has carried out hydrogen mixing and distribution tests to investigate hydrogen distribution behavior in a model containment and at the same time to provide a set of experimental data for the validation of severe-accident analysis codes. Some of the mixing tests have been analyzed by using the MELCOR code, which is an integral severe-accident analysis code used by nuclear safety regulators in Japan, and have been reported previously. In these reports, using the corresponding node compartment where experimental data were measured, there was a large discrepancy for helium concentration in some compartments, such as the gas-injected volume, dead-end compartment, and inside the dome. It was found that the discrepancy came from mainly nonhomogeneous helium gas concentration in these compartments. Noding and flow resistance parameter surveys were performed in the M-2-2 and M-8-1 test analyses to obtain a better prediction.

  5. Norm comparisons of the Spanish-language and English-language WAIS-III: Implications for clinical assessment and test adaptation.

    Science.gov (United States)

    Funes, Cynthia M; Rodriguez, Juventino Hernandez; Lopez, Steven Regeser

    2016-12-01

    This study provides a systematic comparison of the norms of 3 Spanish-language Wechsler Adult Intelligence Scales (WAIS-III) batteries from Mexico, Spain, and Puerto Rico, and the U.S. English-language WAIS-III battery. Specifically, we examined the performance of the 4 normative samples on 2 identical subtests (Digit Span and Digit Symbol-Coding) and 1 nearly identical subtest (Block Design). We found that across most age groups the means associated with the Spanish-language versions of the 3 subtests were lower than the means of the U.S. English-language version. In addition, we found that for most age ranges the Mexican subsamples scored lower than the Spanish subsamples. Lower educational levels of Mexicans and Spaniards compared to U.S. residents are consistent with the general pattern of findings. These results suggest that because of the different norms, applying any of the 3 Spanish-language versions of the WAIS-III generally risks underestimating deficits, and that applying the English-language WAIS-III norms risks overestimating deficits of Spanish-speaking adults. There were a few exceptions to these general patterns. For example, the Mexican subsample ages 70 years and above performed significantly better on the Digit Symbol and Block Design than did the U.S. and Spanish subsamples. Implications for the clinical assessment of U.S. Spanish-speaking Latinos and test adaptation are discussed with an eye toward improving the clinical care for this community. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  6. Compilation of radiation damage test data part III: materials used around high-energy accelerators

    CERN Document Server

    Beynel, P; Schönbacher, H; CERN. Geneva

    1982-01-01

    For pt.II see CERN report 79-08 (1979). This handbook gives the results of radiation damage tests on various engineering materials and components intended for installation in radiation areas of the CERN high-energy particle accelerators. It complements two previous volumes covering organic cable-insulating materials and thermoplastic and thermosetting resins.

  7. Retrofit of waste-to-energy facilities equipped with electrostatic precipitators. Volume III: Test protocol

    Energy Technology Data Exchange (ETDEWEB)

    Rigo, H.G. [Rigo & Rigo Associates, Inc., Berea, OH (US); Chandler, A.J. [A.J. Chandler & Associates, Inc., Toronto, Ontario (Canada)

    1996-04-01

    The American Society of Mechanical Engineers' [ASME] Center for Research and Technology Development [CRTD] has been awarded a subcontract by the National Renewable Energy Laboratory [NREL] to demonstrate the technical performance and viability of flue gas temperature control in combination with dry acid gas reagent and activated carbon injection at an existing electrostatic precipitator [ESP] equipped municipal waste combustor [MWC]. The objective of this proof-of-concept demonstration test is to economically and reliably meet 40 CFR 60 Subpart Cb Emissions Guidelines for MWC's at existing ESP equipped facilities. The effort is being directed by a Subcommittee of tile ASME Research Committee on Industrial and Municipal Wastes [RCIMW] chaired by Dave Hoecke. Mr. Greg Barthold of ASME/CRTD is the Project Manager. ASME/CRTD contracted with Rigo & Rigo Associates, Inc. in cooperation with A.J. Chandler & Associates, Ltd. to be the Principal Investigator for the project and manage the day-t o-day aspects of the program, conduct the testing reduce and interpret the data and prepare the report. Testing will be conducted at the 2 by 210 TPD, ESP equipped MWC at the Davis County Resource Recovery Facility in Layton, Utah. The test plan calls for duplicate metals (Cd, Pb and Hg), dioxin and acid gas runs.

  8. The aminoterminal propeptide of type III procollagen. Studies on physiology and pathophysiology

    DEFF Research Database (Denmark)

    Jensen, L T

    1997-01-01

    The aim of the present study was to examine the physiological basis for the clinical use of serum PIIINP as a marker of the deposition rate of type III collagen. The assumption was that the serum concentration of PIIINP would reflect the turnover of type III collagen and thus directly reflect...... the inflammatory response. For the study we assessed commercially available RIAs and optimised one of them. Porcine PIIINP was purified and compared with human PIIINP. The application of a gentle iodination procedure made it possible to perform tracer studies. An experimental model consisting of a thoracic duct......-venous shunt in conscious pigs was developed. Double and triple isotope tracer techniques were used for kinetic studies in the animal model and in cultures of tubule cells. The rat model with the induction of granulation tissue was used to investigate catabolic states. The anabolic state was studied in humans...

  9. Testing green coffee for ochratoxin A, part III: performance of ochratoxin A sampling plan.

    Science.gov (United States)

    Vargas, Eugenia A; Whitaker, Thomas B; Santos, Eliene A; Slate, Andrew B; Lima, Franisco B; Franca, Regina C A

    2006-01-01

    Green coffee shipments are often inspected for ochratoxin A (OTA) and classified into good or bad categories depending on whether the OTA estimates are above or below a defined regulatory limit. Because of the uncertainty associated with the sampling, sample preparation, and analytical steps of an OTA test procedure, some shipments of green coffee will be misclassified. The misclassification of lots leads to some good lots being rejected (sellers' risk) and some bad lots being accepted (buyers' risk) by an OTA sampling plan. Reducing the uncertainty of an OTA test procedure and using an accept/reject limit less than the regulatory limit can reduce the magnitude of one or both risks. The uncertainty of the OTA test procedure is most effectively reduced by increasing sample size (or increasing the number of samples analyzed), because the sampling step is the largest source of uncertainty in the OTA test procedure. The effects of increasing sample size and changing the sample accept/reject limit relative to the regulatory limit on the performance of OTA sampling plans for green coffee were investigated. For a given accept/reject limit of 5 microg/kg, increasing sample size increased the percentage of lots accepted at concentrations below the regulatory limit and increased the percentage of lots rejected at concentrations above the regulatory limit. As a result, increasing sample size reduced both the number of good lots rejected (sellers' risk) and the number of bad lots accepted (buyers' risk). For a given sample size (1 kg), decreasing the sample accept/reject limit from 5 to 2 microg/kg relative to a fixed regulatory limit of 5 microg/kg decreased the percentage of lots accepted and increased the percentage of lots rejected at all OTA concentrations. As a result, decreasing the accept/reject limit below the regulatory limit increased the number of good lots rejected (sellers' risk), but decreased the number of bad lots accepted (buyers' risk).

  10. Comparison of Individual Performance in Intelligence Tests WAIS III and RPM (Raven's Progressive Matrices)

    OpenAIRE

    Petrů, Vít

    2017-01-01

    This thesis deals with replacement of performative scale of Wechsler Adult Intelligence Scale (3rd revision) through Raven's Standard Progressive Matrices and Advanced Progressive Matrices. In the theoretical part introduces the concepts of intelligence, approaches to its exploration and intelligence tests. The theoretical part is also devoted to the description of the used methods and presents an overview of the research on a similar theme as this work. In the empirical part of the thesis is...

  11. Performance of APACHE III over time in Australia and New Zealand: a retrospective cohort study.

    Science.gov (United States)

    Paul, E; Bailey, M; Van Lint, A; Pilcher, V

    2012-11-01

    The Acute Physiology and Chronic Health Evaluation (APACHE) III-j model has been used for benchmarking intensive care unit (ICU) outcomes in Australia and New Zealand for over a decade. This study assessed performance of the APACHE III-j model in adult patients admitted to Australasian ICUs during a ten-year period. Data were extracted from the Australian and New Zealand Intensive Care Society Adult Patient Database. Performance of APACHE III-j at different time points and within different age strata was evaluated by dividing the whole cohort into five 'two-year' groups. Calibration and discrimination were assessed by the Brier score, Hosmer-Lemeshow C and H statistics, Standardised Mortality Ratio (SMR), Cox calibration regression, calibration curves and area under the receiver operating characteristic curve (AUROC). Model performance within diagnostic categories was evaluated. Between 1 January 2000 and 31 December 2009, 558,585 ICU admissions which met inclusion criteria were included in the analysis. The mean (standard deviation) age was 60.8 (18.4) years and 58.3% were male. Overall observed mortality was 12.6%. The mean (standard deviation) APACHE III-j predicted mortality was 14.5% (21.8). Although discrimination (as measured by AUROC) was preserved over time, all other markers of model performance showed deterioration. There was a significant decrease in SMR in eight of ten most common diagnoses examined. This study demonstrates that performance of APACHE III-j model has deteriorated in Australasian hospitals and there is now a clear need for an updated modelling approach to improve mortality prediction, performance monitoring and quality of research undertaken in Australian and New Zealand ICUs.

  12. Mountain Braking Test Venue Study

    Science.gov (United States)

    2013-12-12

    FMVSS 105 Inertia Brake Dynamometer Test Procedure for vehicles above 4 540 kg GVWR; FMVSS Test Sequence, 2nd Fade Section,” November 2011.(15) Scope...Test Brake Temperature and Speed The U.S. Department of Defense Army Tank Purchase Description 2354A (ATPD-2354A) includes dynamometer test...11, March 1992. [12] "Performance Requirements for Determining Tow -Vehicle Gross Combination Weight Rating and Trailer Weight Rating", SAE Surface

  13. A Study of Low-Wage Workers and Their Response to High Intensity Training. Volume III, Part 1 and Part 2: Appendices B 1-5.

    Science.gov (United States)

    Davis, Earl E.

    This document is the last of a three-volume study designed to examine low-wage, low-skilled workers, within the context of their work environment, and to develop ways of measuring the effects of skill advancement training upon the program participants. Volume III, Parts I and II, contains modified employee pre- and post-test interview schedules…

  14. Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate.

    Science.gov (United States)

    Skarping, G; Brorson, T; Sangö, C

    1991-01-01

    Five men were exposed to toluene diisocyanate (TDI) atmospheres for 7.5 h. The TDI atmospheres were generated by a gas-phase permeation method, and the exposures were performed in an 8-m3 stainless-steel test chamber. The mean air concentration of TDI was ca. 40 micrograms/m3, which corresponds to the threshold limit value (TLV) of Sweden. The inhaled doses of 2,4- and 2,6-TDI were ca. 120 micrograms. TDI in the test chamber air was determined by an HPLC method using the 9-(N-methylaminomethyl)-anthracene reagent and by a continuous-monitoring filter-tape instrument. After hydrolysis of plasma and urine, the related amines, 2,4- and 2,6-toluenediamine 2,4-, and 2,6-TDA), were determined as pentafluoropropionic anhydride (PFPA) derivatives by capillary gas-chromatography using selected ion monitoring (SIM) in the electron-impact mode. The urinary elimination of the TDAs showed a possible biphasic pattern, with rapid first phases for 2,4-TDA (mean t1/2 for the concentration in urine, 1.9 h) and for 2,6-TDA (mean t1/2 for the concentration in urine, 1.6 h). The cumulative amount of 2,4-TDA excreted in urine within 28 h ranged from 8% to 14% of the estimated dose of 2,4-TDI, and the cumulative amount of 2,6-TDA in urine ranged from 14% to 18% of the 2,6-TDI dose. The average urinary level of 2,4-TDA was 5 micrograms/l in the 6 to 8-h sample (range 2.8-9.6 micrograms/l), and the corresponding value for 2,6-TDA was 8.6 micrograms/l (range, 5.6-16.6 micrograms/l). Biological monitoring of exposure to 2,4- and 2,6-TDI by analysis of 2,4- and 2,6-TDA in urine is feasible.

  15. Plasma transport in stochastic magnetic fields. III. Kinetics of test-particle diffusion

    Energy Technology Data Exchange (ETDEWEB)

    Krommes, J.A.; Oberman, C.; Kleva, R.G.

    1982-07-01

    A discussion is given of test particle transport in the presence of specified stochastic magnetic fields, with particular emphasis on the collisional limit. Certain paradoxes and inconsistencies in the literature regarding the form of the scaling laws are resolved by carefully distinguishing a number of physically distinct correlation lengths, and thus by identifying several collisional subregimes. The common procedure of averaging the conventional fluid equations over the statistics of a random field is shown to fail in some important cases because of breakdown of the Chapman-Enskog ordering in the presence of a stochastic field component with short autocorrelation length. A modified perturbation theory is introduced which leads to a Kubo-like formula valid in all collisionality regimes. The direct-interaction approximation is shown to fail in the interesting limit in which the orbit exponentiation length L/sub K/ appears explicitly. A higher order renormalized kinetic theory in which L/sub K/ appears naturally is discussed and used to rederive more systematically the results of the heuristic scaling arguments.

  16. Teste de inteligência WISC-III adaptando para a população brasileira

    Directory of Open Access Journals (Sweden)

    Vera L. M. Figueiredo

    Full Text Available O presente artigo tem por objetivo mostrar alguns resultados encontrados até o momento, na pesquisa de adaptação do teste de inteligência WISC- III (Wechsler Intelligence Scale for ChildrenThird Edition. Os dados apresentados referem-se à aplicação do conjunto verbal do teste a uma amostra piloto de 116 crianças com idades entre 6 e 16 anos, matriculadas na rede de escolas públicas e privadas da cidade do Rio Grande (RS. Os resultados evidenciaram índices de validade e consistência interna do conjunto verbal do teste. Observou-se a relevância da idade, da repetência e do local da escola devendo estas variáveis serem controladas na pesquisa de adaptação. Há necessidade de alteração de alguns itens, principalmente nos subtestes Informação e Vocabulário.

  17. Evaluation of exposure conditions for the water-side corrosion test of a sodium heated steam generator evaporator model employing a duplex tube (2160 hours at critical heat flux - phase III SSGM tests). [LMFBR

    Energy Technology Data Exchange (ETDEWEB)

    Waszink, R.P.; Hwang, J.Y.; Efferding, L.E.

    1975-12-01

    This report describes the specialized corrosion test water steam loop, test procedures, test conditions, and test results. A complete water chemistry and thermal hydraulic performance history is given and evaluated for the Phase III test program. The movement of the dryout location and the heat flux variations in pre- and post-critical heat flux regions are documented and analyzed. On seven occasions during the course of the test program to date, the operating conditions drifted from the CHF reference Phase III operation in the dryout regime into the DNB regime. The corresponding corrosion mechanism experienced differing exposure conditions on these occasions. CHF sensitivity to this apparent drift behavior is evaluated.

  18. Classroom Interaction in Effective and Ineffective Schools: Preliminary Results from Phase III of the Louisiana School Effectiveness Study

    Science.gov (United States)

    Stringfield, Samuel; Teddlie, Charles; Suarez, Sandra

    2017-01-01

    A major focus in Phase III of the Louisiana School Effectiveness Study is on the relationship between classroom interaction patterns and school effectiveness. This paper presents observations on similarities and differences between prior teacher and school effectiveness studies, the LSES-III methodology, and preliminary results from one of the…

  19. Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl-4-chlorobenzenesulphonamide and Its Neodymium(III and Thallium(III Complexes

    Directory of Open Access Journals (Sweden)

    Lawrence Nnamdi Obasi

    2017-02-01

    Full Text Available N-(Benzothiazol-2-yl-4-chlorobenzenesulphonamide (NBTCS was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III and thallium(III complexes of the ligand were also synthesized. Both ligand and metal complexes were characterized using UV-Vis, IR, 1H- and 13C-NMR spectroscopies, elemental analysis and molar conductance measurement. IR studies revealed that the ligand is tridentate and coordinates to the metal ions through nitrogen and oxygen atoms of the sulphonamide group and nitrogen atom attached to benzothiazole ring. The neodymium(III complex displays a coordination number of eight while thallium(III complex displays a coordination number of six. The ligand and its complexes were screened in vitro for their antibacterial activities against Escherichia coli strains (E. coli 6 and E. coli 13, Proteus species, Staphylococcus aureus and Pseudomonas aeruginosa using the agar well diffusion technique. The synthesized compounds were found to be more active against the microorganisms screened relative to ciprofloxacin, gentamicin and co-trimoxazole.

  20. Impact of a Solution for the Study of Neural Pathways in Morphophysiology III

    OpenAIRE

    José Manuel Ruiz Medina; Alicia Ríos Carbonell; Gisela Trevín Fernández; Elnis Quiala Ballester; Vivian Santoya Varela

    2013-01-01

    Background: current conditions for teaching Morphophysiology subject and awareness of the historical difficulties that students face in understanding the morphological and functional characteristics of neural pathways require a solution. Objective: to create a set of means in order to provide a practical resource for the study of the morphological and functional characteristics of the neural pathways and to assess the impact of its implementation in Morphophysiology III teaching. Methods: we ...

  1. Smoke Emission Tests on Series II and Series III Allison T56 Turboprop Engines

    Science.gov (United States)

    1986-12-01

    the secondary zone where combustion should be completed. Similarly the secondary zone includes half of the air entering the holes in the third segment ...No. 486 Squadron HQ RAAF Edinburgh CO, No. 492 Squadron RAAF Resident Engineer Qantas RAAF College, Point Cook Central Studies Establishment...Library Qantas Airways Limited Gas & Fuel Corporation of Vic, Manager Scientific Services SEC of Vic, Herman Research Laboratory, Library ■-WJMtfl’W

  2. Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study

    Science.gov (United States)

    Heshmat, Ramin; Shafiee, Gita; Qorbani, Mostafa; Azizi-Soleiman, Fatemeh; Djalalinia, Shirin; Esmaeil Motlagh, Mohammad; Ardalan, Gelayol; Ahadi, Zeinab; Safari, Omid; Safiri, Saeid; Kelishadi, Roya

    2016-01-01

    Introduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents. Methods: In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly from the childhood and Adolescence Surveillance and Prevention of Adult Non communicable disease (CASPIAN-III) study. MetS was defined according to the Adult Treatment Panel III (ATP III) criteria modified for children and adolescents. Anthropometric measures (including body mass index [BMI], waist circumference [WC] and waist to height ratio [WHtR]), blood pressure (BP) and biochemical data (including fasting blood sugar [FBS], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC] and gerlin) were measured. Results: Total ghrelin level was significantly higher in students without MetS compared to those with MetS (748.89 ± 85.04 vs. 728.72 ± 90.36 [pg/mL]; P adolescents. PMID:27777695

  3. Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study.

    Science.gov (United States)

    van Capelleveen, Julian C; Bernelot Moens, Sophie J; Yang, Xiaohong; Kastelein, John J P; Wareham, Nicholas J; Zwinderman, Aeilko H; Stroes, Erik S G; Witztum, Joseph L; Hovingh, G Kees; Khaw, Kay-Tee; Boekholdt, S Matthijs; Tsimikas, Sotirios

    2017-06-01

    Apolipoprotein C-III (apoC-III) is a key regulator of triglyceride metabolism. Elevated triglyceride-rich lipoproteins and apoC-III levels are causally linked to coronary artery disease (CAD) risk. The mechanism(s) through which apoC-III increases CAD risk remains largely unknown. The aim was to confirm the association between apoC-III plasma levels and CAD risk and to explore which lipoprotein subfractions contribute to this relationship between apoC-III and CAD risk. Plasma apoC-III levels were measured in baseline samples from a nested case-control study in the European Prospective Investigation of Cancer (EPIC)-Norfolk study. The study comprised 2711 apparently healthy study participants, of whom 832 subsequently developed CAD. We studied the association of baseline apoC-III levels with incident CAD risk, lipoprotein subfractions measured by nuclear magnetic resonance spectroscopy and inflammatory biomarkers. ApoC-III levels were significantly associated with CAD risk (odds ratio, 1.91; 95% confidence interval, 1.48-2.48 for highest compared with lowest quintile), retaining significance after adjustment for traditional CAD risk factors (odds ratio, 1.47; 95% confidence interval, 1.11-1.94). ApoC-III levels were positively correlated with triglyceride levels, (r=0.39), particle numbers of very-low-density lipoprotein (r=0.25), intermediate-density lipoprotein (r=0.23), small dense low-density lipoprotein (r=0.26), and high-sensitivity C-reactive protein (r=0.15), whereas an inverse correlation was observed with large low-density lipoprotein particle number (r=-0.11), PC-reactive protein. ApoC-III levels are significantly associated with incident CAD risk. Elevated levels of remnant lipoproteins, small dense low-density lipoprotein, and low-grade inflammation may explain this association. © 2017 American Heart Association, Inc.

  4. A prospective longitudinal study of neuropsychological and psychosocial factors in asymptomatic individuals at risk for HTLV-III/LAV infection in a methadone program: preliminary findings.

    Science.gov (United States)

    Silberstein, C H; McKegney, F P; O'Dowd, M A; Selwyn, P A; Schoenbaum, E; Drucker, E; Feiner, C; Cox, C P; Friedland, G

    1987-02-01

    To test the hypothesis that cognitive impairment may be present early in the course of HTLV-III/LAV infection, intravenous drug abusers (IDVAs) without overt symptoms of AIDS related illness were tested with standard neuropsychological and psychosocial measures. This study is the baseline for a prospective longitudinal study of the natural history of HTLV-III/LAV infection in this high risk population. Of 211 subjects initially evaluated, 70 (33%) were HTLV-III/LAV seropositive and 141 (67%) were seronegative. At the baseline, by univariate analysis, the seropositive IVDAs were significantly (p less than .05) more impaired than seronegatives on 4 of 8 measures: Finger Tapping--dominant, hand, Digit Span Forward, Trail making A and WAIS-Similarities. However, by multivariate analysis the seropositives were significantly more impaired only on the WAIS-Similarities and Wechsler--Associative Learning tests. Multiple factors such as drug use and psychological stress may have influenced test performance. These preliminary results, however, suggest that seropositive IVDAs may show evidence of impaired neuropsychological function even in the absence of AIDS related symptoms and are consistent with the hypothesis of the early neurotropism of HTLV-III/LAV.

  5. Electrochemical study of the Eu(III)/Eu(II) system in molten fluoride media

    Energy Technology Data Exchange (ETDEWEB)

    Massot, L. [Universite de Toulouse, INPT, UPS, Laboratoire de Genie Chimique, Departement Procedes Electrochimiques, F-31062 Toulouse cedex 09 (France); CNRS, Laboratoire de Genie Chimique, F-31062 Toulouse cedex 09 (France)], E-mail: massot@chimie.ups-tlse.fr; Chamelot, P.; Cassayre, L.; Taxil, P. [Universite de Toulouse, INPT, UPS, Laboratoire de Genie Chimique, Departement Procedes Electrochimiques, F-31062 Toulouse cedex 09 (France); CNRS, Laboratoire de Genie Chimique, F-31062 Toulouse cedex 09 (France)

    2009-11-01

    The electrochemical behaviour of the Eu(III)/Eu(II) system was examined in the molten eutectic LiF-CaF{sub 2} on a molybdenum electrode, using cyclic voltammetry, square wave voltammetry and chronopotentiometry. It was observed that EuF{sub 3} is partly reduced into EuF{sub 2} at the operating temperatures (1073-1143 K). The electrochemical study allowed to calculate both the equilibrium constant and the formal standard potential of the Eu(III)/Eu(II) system. The reaction is limited by the diffusion of the species in the solution; their diffusion coefficients were calculated at different temperatures and the values obey Arrhenius' law. The second system Eu(II)/Eu takes place out of the electrochemical window on an inert molybdenum electrode, which inhibits the extraction of Eu species from the salt on such a substrate.

  6. X-ray diffraction, FTIR, UV-VIS and SEM studies on chromium (III) complexes

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, Ashutosh; Dwivedi, Jagrati, E-mail: hemu.dwi@gmail.com; Shukla, Kritika [School of Physics, Devi Ahilya University, Khandwa Road, Indore-452001 (India)

    2015-06-24

    Five Chromium (III) complexes have been prepared using Schiff base ligands which derived from benzoin and five different amino acids (H{sub 2}N-R). Samples were characterized by XRD, FTIR, UV-VIS and SEM method. X-Ray diffraction pattern analyzed that all chromium (III) complexes have hexagonal structure and crystalline, in nature, using Bruker D8 Advance instrument. Using VERTAX 70, FTIR spectroscopy reveals that Samples have (C=N), (C-O), (M-N) and (M-O) bonds in the range of 4000-400cm{sup −1}. UV-VIS spectroscopy give information that samples absorb the visible light which is in the range of 380-780nm. For this, Lambda 960 spectrometer used. SEM is designed for studying of the solid objects, using JEOL JSM 5600 instrument.

  7. PENGGUNAAN FACE-MASK & EKSPANSI PALATAL PADA PERAWATAN MALOKLUSI KLAS III (Studi Pustaka

    Directory of Open Access Journals (Sweden)

    Krisnawati Krisnawati

    2015-08-01

    Full Text Available Class III skeletal anomaly is one of the most difficult malocclusions to correct in orthodontics. Orthodontist usually involved chincup appliances to restrain mandibular growth, camouflage techniques to advances maxillary incisors and retract mandibular incisors or waiting untul growth ceased to pursue orthognathic surgery. Many studies found that most of Class III malocclusions were characterized by maxillary retrognathism. In the late 1960s, the Delaire mask was popularized to protract the maxilla. The development of maxillary protraction with facemask and palatal expansion have provided a predictable and effective approach to managing treatment that was once considered difficult. Although no significant difference was found between early or late treatment group, the effect of improvement in facial aesthetics on psychosocial development resulted in a significant advantage for early treatment. However, the effects of face mask therapy should be evaluated over the long term in order to determine the relaps tendency.

  8. Change in muscle strength over time in spinal muscular atrophy types II and III. A long-term follow-up study

    DEFF Research Database (Denmark)

    Werlauff, U; Vissing, J; Steffensen, B F

    2012-01-01

    Whether muscle strength deteriorates with time in spinal muscular atrophy (SMA) types II and III is still debated. We present a long-term follow-up study on muscle strength in 30 patients with SMA types II and III. Median follow-up time was 17 years. Median number of assessments was four. All...... patients were assessed by Manual Muscle Testing (MMT), Brooke upper limb scale and EK scale. There was a difference in muscle strength of the upper limbs from first to last assessment in SMA II (p...

  9. Effect of fiber posts on the fracture resistance of maxillary central incisors with Class III restorations: An in vitro study.

    Science.gov (United States)

    Abduljawad, Mohammed; Samran, Abdulaziz; Kadour, Jadalkareem; Karzoun, Wassim; Kern, Matthias

    2017-07-01

    Endodontically treated teeth with Class III restorations show reduced fracture resistance. The placement of glass fiber posts may affect fracture resistance and should be further evaluated. The purpose of this in vitro study was to evaluate the effect of fiber posts on the fracture resistance of endodontically treated maxillary central incisors with Class III restorations. Forty extracted human maxillary central incisors were selected and divided into 4 test groups (n=10 each) according to the restoration strategy: control group; endodontically treated teeth without endodontic posts (GHT); endodontically treated teeth with 2 Class III restorations simulating coronal destruction (GCT); endodontically treated teeth with 2 Class III restorations and a carbon fiber post (GCF); and endodontically treated teeth with 2 Class III restorations and a glass-fiber post (GGF). The fiber posts were adhesively cemented with composite resin cement, and the cavities were restored with composite resin. After 3 months of water storage, all specimens were loaded at 45 degrees in a universal testing machine until fracture and evaluated for fracture mode. The data were analyzed using 1-way ANOVA, followed by the Tukey honest significant difference multiple comparisons test (α=.05). Mean ±SD failure loads ranged from 687.5 ±84.0 N to 943.8 ±93.1 N. One-way ANOVA revealed a statistically significant difference among the groups (P≤.05). The control group (GHT) had significantly higher resistance to fracture than the other groups (P≤.05). Within the limitations of this in vitro study, placement of a fiber post did not affect the fracture resistance of endodontically treated maxillary central incisors with 2 Class III restorations. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  10. Laser-Induced Luminescence Study of Samarium(III) Thiodiglycolate Complexes

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Dong Yong; Lee, Eil Hee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kimura, Takaumi [Japan Atomic Energy Research Institute, Ibaraki-ken (Japan)

    2003-09-15

    The hydration number of Sm(III) has been obtained by using the difference in the decay rate constants in H{sub 2}O and D{sub 2}O solutions. In general, k{sub obs}(H{sub 2}O) >> k{sub obs}(D{sub 2}O), k{sub obs}(D{sub 2}O) ≅ constant, and ligands are not as effective in causing non-radiative de-excitation of the excited state. For Sm(III), a relationship has been proposed in which the hydration number is related directly to the decay rate constant in H{sub 2}O. If there is no contribution from the ligand to the de-excitation of the luminescence excited state, the hydration of Sm(III) in the different complexes can be obtained directly from the values of k{sub obs} measured in H{sub 2}O. The number and the geometric distribution of solvent molecules around a metal ion in solution are an important factor in the structural and chemical behavior of cation. Indeed, such information has been utilized to design novel ionophores and receptors. However, there have been few studies of hydration structure for lanthanides. The fact that many f-element salts which have relatively large lattice energies are fairly soluble in water is a reflection of the strength of the interactions between the metal cations and water molecules.

  11. Relationship between Class III malocclusion and hyoid bone displacement during swallowing: a cine-magnetic resonance imaging study.

    Science.gov (United States)

    Gokce, Sila Mermut; Gokce, Hasan Suat; Gorgulu, Serkan; Karacay, Seniz; Akca, Eralp; Olmez, Huseyin

    2012-08-01

    The displacement of the hyoid bone (HB) is a critical biomechanical component of the swallowing function. The aim of this study was to evaluate the swallowing-induced vertical and horizontal displacements of the HB in subjects with 2 different magnitudes of skeletal Class III malocclusion, by means of real-time, balanced turbo-field-echo (B-TFE) cine-magnetic resonance imaging. The study population comprised 19 patients with mild skeletal Class III malocclusion, 16 with severe skeletal Class III malocclusion, and 20 with a skeletal Class I relationship. Before the commencement of the study, all subjects underwent cephalometric analysis to identify the nature of skeletal malformations. B-TFE images were obtained for the 4 consecutive stages of deglutition as each patient swallowed 10 mL of water, and the vertical and horizontal displacements of the HB were measured at each stage. At all stages of swallowing, the vertical position of the HB in the severe Class III malocclusion group was significantly lower than those in the mild Class III and Class I malocclusion groups. Similarly, the horizontal displacement of the HB was found to be significantly associated with the severity of malocclusion, i.e., the degree of Class III malocclusion, while the amount of anterior displacement of the HB decreased with an increase in the severity of the Class III deformity. Our findings indicate the existence of a relationship between the magnitude of Class III malocclusion and HB displacement during swallowing.

  12. Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study.

    Science.gov (United States)

    Tomin, M; Tomić, S

    2017-10-24

    Dipeptidyl peptidase III (DPP III) from the human gut symbiont Bacteroides thetaiotaomicron (Bt) is the first identified prokaryotic DPP III orthologue. It has low sequence similarity to the thoroughly studied human DPP III, and differently from eukaryotic orthologues it has a cysteine (Cys450) residue in the zinc-binding motif HEXXGH (HECLGH). The recently determined crystal structure of BtDPP III showed that its 3D structure, similar to the structure of the human DPP III, consists of two domains with a wide cleft in between. Although such a striking similarity of the 3D structures of orthologues with low sequence similarity is not surprising, it is no guarantee for similarity of their dynamic properties and the catalytic performance. Here, we report the results of the molecular modelling study of BtDPP III, wild type and its C450S mutant, as well as their complexes with characteristic DPP III substrates Arg-Arg-2-naphthylamide (RRNA) and Lys-Ala-2-naphtylamide (KANA). During several hundred nanoseconds of all-atom MD simulations of the wild type protein, the long range conformational changes, which can be described as protein 'closing', have been traced. We have determined a similar conformational change for the human orthologue as well. However, the amplitude of the change is lower for BtDPP III than for the human DPP III. The MD simulations have been performed using ff03, ff12SB and ff14SB force fields wherein the results of the last two better fit to the experimental results. The hydrogen bond analysis indicates reasons for higher substrate specificity of BtDPP III towards RRNA than KANA as well as for the decrease of the RRNA hydrolysis rate induced by the Cys450 to Ser mutation. The obtained results are in line with the experimental data.

  13. Construct Validity and Measurement Invariance of the Peabody Picture Vocabulary Test-III Form A in the Performance of Struggling Adult Readers: Rasch Modeling.

    Science.gov (United States)

    Pae, Hye; Greenberg, Daphne; Morris, Robin D

    2012-01-01

    PURPOSE: The aim of this study was to apply the Rasch model to an analysis of the psychometric properties of the PPVT-III Form A items with struggling adult readers. METHODS: The PPVT-IIIA was administered to 229 African-American adults whose isolated word reading skills were between third and fifth grades. Conformity of the adults' performance on the PPVT-III items was evaluated using the Winsteps software. RESULTS: Analysis of all PPVT-IIIA items combined did not fully support its use as a useful measure of receptive vocabulary for struggling adult readers who were African Americans. To achieve an adequate model fit, items 73 through item 156 were analyzed. The items analyzed showed adequate internal consistency reliability, unidimensionality, and freedom from differential item functioning for ability, gender, and age, with a minor modification. DISCUSSION: With an appropriate treatment of misfit items, the results supported the measurement properties, internal consistency reliability, unidimensionality of the PPVT-IIIA items, and measurement invariance of the test across subgroups of ability, age, and gender.

  14. Invariance of Woodcock-Johnson III Scores for Students with Learning Disorders and Students without Learning Disorders

    Science.gov (United States)

    Benson, Nicholas; Taub, Gordon E.

    2013-01-01

    The purpose of this study was to test the invariance of scores derived from the Woodcock-Johnson III Tests of Cognitive Ability (WJ III COG) and Woodcock-Johnson III Tests of Academic Achievement (WJ III ACH) across a group of students diagnosed with learning disorders (n = 994) and a matched sample of students without known clinical diagnoses (n…

  15. Complexation of lactate with neodymium(III) and europium(III) at variable temperatures: studies by potentiometry, microcalorimetry, optical absorption, and luminescence spectroscopy.

    Science.gov (United States)

    Tian, Guoxin; Martin, Leigh R; Rao, Linfeng

    2010-11-15

    The complexation of neodymium(III) and europium(III) with lactate was studied at variable temperatures by potentiometry, absorption spectrophotometry, luminescence spectroscopy, and microcalorimetry. The stability constants of three successive lactate complexes (ML(2+), ML(2)(+), and ML(3)(aq), where M stands for Nd and Eu and L stands for lactate) at 10, 25, 40, 55, and 70 °C were determined. The enthalpies of complexation at 25 °C were determined by microcalorimetry. Thermodynamic data show that the complexation of trivalent lanthanides (Nd(3+) and Eu(3+)) with lactate is exothermic and the complexation becomes weaker at higher temperatures. Results from optical absorption and luminescence spectroscopy suggest that the complexes are inner-sphere chelate complexes in which the protonated α-hydroxyl group of lactate participates in the complexation.

  16. Complexation of Lactate with Nd(III) and Eu(III) at Variable Temperatures: Studies by Potentiometry, Microcalorimetry, Optical Absorption and Luminescence Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Guoxin; Martin, Leigh R.; Rao, Linfeng

    2010-10-01

    Complexation of neodymium(III) and europium(III) with lactate was studied at variable temperatures by potentiometry, absorption spectrophotometry, luminescence spectroscopy and microcalorimetry. Stability constants of three successive lactate complexes (ML{sup 2+}, ML{sup 2+} and ML{sub 3}(aq), where M stands for Nd and Eu, and L stands for lactate) at 10, 25, 40, 55 and 70 C were determined. The enthalpies of complexation at 25 C were determined by microcalorimetry. Thermodynamic data show that the complexation of trivalent lanthanides (Nd{sup 3+} and Eu{sup 3+}) with lactate is exothermic, and the complexation becomes weaker at higher temperatures. Results from optical absorption and luminescence spectroscopy suggest that the complexes are inner-sphere chelate complexes in which the protonated {alpha}-hydroxyl group of lactate participates in the complexation.

  17. Apriori feasibility testing of randomized clinical trial design in patients with cleft deformities and Class III malocclusion.

    Science.gov (United States)

    McIlvaine, Elizabeth; Borzabadi-Farahani, Ali; Lane, Christianne J; Azen, Stanley P; Yen, Stephen L-K

    2014-05-01

    To assess the feasibility of randomizing treatment (surgical vs. non-surgical) for correction of a Class III malocclusion (underbite) resulting from an earlier repair of cleft lip and palate. Surveys about willingness to accept randomized treatment during adolescence were mailed to the parents of cleft lip and palate patients under the care of Children's Hospital Los Angeles between 2005 and 2010. The inclusion criteria were patients with cleft lip and palate, Class III malocclusion due to maxillary deficiency, and absence of medical and cognitive contraindications to treatment. Out of 287 surveys, 82 (28%) were completed and returned; 47% of the subjects held a strong treatment preference (95% CI, 35-58%), while 30% were willing to accept randomization (95% CI, 20-41%). Seventy-eight percent would drop out of a randomized trial if dissatisfied with the assigned treatment (95% CI, 67-86%). The three most commonly cited reasons for being unwilling to accept random treatment assignment were 1) the desire for doctors to choose the best treatment, 2) the desire for parents to have input on treatment, and 3) the desire to correct the underbite as early as possible. Based on this study, parents and patients would be unwilling to accept a randomly assigned treatment and would not remain in an assigned group if treatment did not meet expectations. This highlight the limitations associated with randomization trials involving surgical modalities and provide justification for other research models (e.g., cohort studies) to compare two treatment options when randomization is not feasible. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  18. Role of Fe(III)-carboxylates in AMZ photodegradation: A response surface study based on a Doehlert experimental design.

    Science.gov (United States)

    Graça, Cátia A L; Correia de Velosa, Adriana; Teixeira, Antonio Carlos S C

    2017-10-01

    Photochemical redox reactions of Fe(III) complexes in surface waters are important sources of radical species, therefore contributing to the sunlight-driven elimination of waterborne recalcitrant contaminants. In this study, the effects of three Fe(III)-carboxylates (i.e., oxalate, citrate, and tartrate) on the UVA photoinduced oxidation of the herbicide amicarbazone (AMZ) were investigated. A Doehlert experimental design was applied to find the Fe(III):ligand ratios and pH that achieved the fastest AMZ degradation rate. The results indicated optimal ratios of 1:10 (Fe(III):oxalate), 1:4 (Fe(III):citrate), and 1:1 (Fe(III):tartrate), with the [Fe(III)]0 set at 0.1 mmol L-1 and the best pH found to be 3.5 for all the complexes. In addition, a statistical model that predicts the observed degradation rate constant (kobs) as a function of pH and Fe(III):carboxylate ratio was obtained for each complex, enabling AMZ-photodegradation predictions based on these two variables. To the best of our knowledge, this is the first time that such models are proposed. Not only the pH-dependent speciation of Fe(III) in solution but also the time profiles of photogenerated OH, Fe(II), and H2O2 gave appropriate support to the experimental results. Additional experiments using a sampled sewage treatment plant effluent suggest that the addition of aqua and/or Fe(III)-oxalate complexes to the matrix may also be effective for AMZ removal from natural waters in case their natural occurrence is not high enough to promote pollutant degradation. Therefore, the inclusion of Fe(III)-complexes in investigations dealing with the environmental fate of emerging pollutants in natural waterbodies is strongly recommended. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Tank vapor sampling and analysis data package for tank 241-C-106 waste retrieval sluicing system process test phase III

    Energy Technology Data Exchange (ETDEWEB)

    LOCKREM, L.L.

    1999-08-13

    This data package presents sampling data and analytical results from the March 28, 1999, vapor sampling of Hanford Site single-shell tank 241-C-106 during active sluicing. Samples were obtained from the 296-C-006 ventilation system stack and ambient air at several locations. Characterization Project Operations (CPO) was responsible for the collection of all SUMMATM canister samples. The Special Analytical Support (SAS) vapor team was responsible for the collection of all triple sorbent trap (TST), sorbent tube train (STT), polyurethane foam (PUF), and particulate filter samples collected at the 296-C-006 stack. The SAS vapor team used the non-electrical vapor sampling (NEVS) system to collect samples of the air, gases, and vapors from the 296-C-006 stack. The SAS vapor team collected and analyzed these samples for Lockheed Martin Hanford Corporation (LMHC) and Tank Waste Remediation System (TWRS) in accordance with the sampling and analytical requirements specified in the Waste Retrieval Sluicing System Vapor Sampling and Analysis Plan (SAP) for Evaluation of Organic Emissions, Process Test Phase III, HNF-4212, Rev. 0-A, (LMHC, 1999). All samples were stored in a secured Radioactive Materials Area (RMA) until the samples were radiologically released and received by SAS for analysis. The Waste Sampling and Characterization Facility (WSCF) performed the radiological analyses. The samples were received on April 5, 1999.

  20. Synthesis, spectroscopic, thermal and antimicrobial studies of neodymium(III) and samarium(III) complexes derived from tetradentate ligands containing N and S donor atoms

    Science.gov (United States)

    Ain, Qurratul; Pandey, S. K.; Pandey, O. P.; Sengupta, S. K.

    2015-04-01

    Trivalent lanthanide complexes of the type [Ln(L)Cl(H2O)2] (where Ln = Nd(III) or Sm(III) and LH2 = Schiff bases derived by the condensation of 3-(phenyl/substitutedphenyl)-4-amino-5-mercapto-1,2,4-triazole with diacetyl/benzil) have been synthesized by the reactions of anhydrous lanthanide(III) chloride with Schiff bases in methanol. The structures of the complexes have been proposed on the basis of elemental analysis, electrical conductance, magnetic moment, spectroscopic measurements (IR, 1H, 13C NMR and UV-vis spectra) and X-ray diffraction studies. The spectral data reveal that the Schiff base ligands behave as dibasic tetradentate chelating agents having coordination sites at two thiol sulfur atoms and two azomethine nitrogen atoms. The presence of coordinated water in metal complexes was confirmed by thermal and IR data of the complexes. All the Schiff bases and their metal complexes have also been screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus and antifungal activities against Aspergillus niger, Curvularia pallescens and Colletotrichum capsici.

  1. Photoluminescence studies of a Terbium(III) complex as a fluorescent probe for DNA detection

    Energy Technology Data Exchange (ETDEWEB)

    Khorasani-Motlagh, Mozhgan, E-mail: mkhorasani@chem.usb.ac.ir; Noroozifar, Meissam; Niroomand, Sona; Moodi, Asieh

    2013-11-15

    The photoluminescence properties of a Tb(III) complex of the form [Tb(phen){sub 2}Cl{sub 3}·OH{sub 2}] (phen=1,10-phenanthroline) in different solvents are presented. It shows the characteristic luminescence of the corresponding Ln{sup 3+} ion in the visible region. The emission intensity of this complex in coordinating solvent is higher than non-coordinating one. The suggested mechanism for the energy transfer between the ligand and Tb{sup 3+} ion is the intramolecular energy transfer mechanism. The interactions of the Tb(III) complex with fish salmon DNA are studied by fluorescence spectroscopy, circular dichroism study and viscosity measurements. The results of fluorescence titration reveal that DNA strongly quenches the intrinsic fluorescence of the complex through a static quenching procedure. The binding constant (K{sub b}) of the above metal complex at 25 °C is determined by the fluorescence titration method and it is found to be (8.06±0.01)×10{sup 3} M{sup −1}. The thermodynamic parameters (ΔH{sup 0}>0, ΔS{sup 0}>0 and ΔG{sup 0}<0) indicate that the hydrophobic interactions play a major role in DNA–Tb complex association. The results support the claim that the title complex bonds to FS-DNA by a groove mode. -- Highlights: • Photoluminescence of [Tb(phen){sub 2}Cl{sub 3}·OH{sub 2}] in different solvents are studied. • Tb(III) complex shows good binding affinity to FS DNA with K{sub b}=(8.06±0.01)×10{sup 3} M{sup −1}. • Viscosity of DNA almost unchanged by increasing amount of Tb complex. • CD spectrum of DNA has a little change with increasing amount of Tb complex. • Thermodynamic parameters indicate that the binding reaction is entropically driven.

  2. Dentofacial effects of bone-anchored maxillary protraction: a controlled study of consecutively treated Class III patients.

    Science.gov (United States)

    De Clerck, Hugo; Cevidanes, Lucia; Baccetti, Tiziano

    2010-11-01

    In this cephalometric investigation, we analyzed the treatment effects of bone-anchored maxillary protraction (BAMP) with miniplates in the maxilla and mandible connected by Class III elastics in patients with Class III malocclusion. The treated sample consisted of 21 Class III patients consecutively treated with the BAMP protocol before the pubertal growth spurt (mean age, 11.10 ± 1.8 years) and reevaluated after BAMP therapy, about 1 year later. The treated group was compared with a matched control group of 18 untreated Class III subjects. Significant differences between the treated and control groups were assessed with independent-sample t tests (P maxillary structures of about 4 mm, and favorable mandibular changes exceeded 2 mm. Copyright © 2010 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

  3. [Cone-beam CT study for the oropharyngeal airway volume and hyoid position of adults Class III skeletal malocclusion].

    Science.gov (United States)

    Li, Zhi-min; Wu, Jie; Men, Hai-yan; Li, Hong-fa

    2015-06-01

    Using cone-beam CT (CBCT) and Invivo5 software to measure the oropharyngeal airway volume and hyoid position of adults Class III skeletal malocclusion and analyze the influence of the maxillary or mandibular position, in order to evaluate oropharynx airway volume and hyoid position ,and provide guidance for reasonable and effective treatment. One hundred and eighty cases were randomly selected from CBCT data and divided into three groups. Invivo5 software was used to rebuild 3D image data and establish a 3D coordinate system, then to measure OPV and hyoid position. LSD t test was performed between each group with SPSS 19.0 software package. OPV for mandibular protrusion of Class III was significantly higher than maxillary retrusion of Class III and Class I (PClass I and maxillary retrusion of Class III; H-VPS had significant difference as follows: mandibular retrusion of Class III, maxillary retrusion of Class III,and Class I (PClass III was significantly higher than maxillary retrusion of Class III and Class I (PClass I and maxillary retrusion of Class III. The three-dimensional features of airway were different as adults have different types of skeletal malocclusion. The mandibular sagittal position and length had more significant influences on pharyngeal airway volume, shape, direction, and hyoid sagittal position compared with the maxilla. CBCT and Invivo5 are practical tools for evaluation of airway, which can provide clinical evaluation of the three-dimensional features of airway and hyoid position of different skeletal malocclusion, and provide guidance in the formulation of reasonable and effective treatment plan.

  4. Synthesis, structural characterization, luminescent properties and theoretical study of three novel lanthanide metal-organic frameworks of Ho(III), Gd(III) and Eu(III) with 2,5-thiophenedicarboxylate anion

    Science.gov (United States)

    Marques, Lippy F.; Correa, Charlane C.; Ribeiro, Sidney J. L.; dos Santos, Molíria V.; Dutra, José Diogo L.; Freire, Ricardo O.; Machado, Flávia C.

    2015-07-01

    In this paper, the synthesis of three new metal-organic frameworks of lanthanides (LnMOFs) {[Ln2(2,5-tdc)3(dmso)2]·H2O}n (Ln=Ho (1); Gd (2); Eu (3); 2,5-tdc=2,5-thiophenedicarboxylate anion; dmso=dimethylsulfoxide), and their complete characterization, including single crystal X-ray diffraction, FTIR spectroscopy and thermogravimetric analysis are reported. In especial, photophysical properties of Eu(III) complex have been studied in detail via both theoretical and experimental approaches. Crystal structure of (1) reveals that each lanthanide ion is seven-coordinated by oxygen atoms in an overall distorted capped trigonal - prismatic geometry. The 2,5-tdc2- ligands connect four Ln(III) centers, adopting (κ1-κ1)-(κ1-κ1)-μ4 coordination mode, generating an 8-connected uninodal 3D network. In addition, theoretical studies for Eu(III) complex were performed using the Sparkle model for lanthanide complexes.

  5. Denture-frame modifications in class III patients treated with rapid palatal expansion and facemask: a prospective controlled study.

    Science.gov (United States)

    Migliorati, M; Signori, A; Isaia, L; Menini, A; Rubiano, R; Aonzo, E; Silvestrini Biavati, A

    2015-06-01

    The aim of this prospective controlled investigation was to analyze the short-term cephalometric treatment outcomes, according to the denture frame analysis proposed by Sato, of rapid palatal expansion (RPE) and facial mask (FM) therapy. A group of 21 patients with Class III malocclusion treated with the RPE and FM (TG) was compared with untreated Class III controls (CG). The mean age of treatment group was 8.8 years; treatment consisted of 4 weeks of RPE activation (0.20 mm/die) followed by 14 hours wear of the FM for a mean of 333.1 days. As CG were used the data published by Tanaka and Sato. Pre- and post-treatment cephalometric values were compared and statistical analyzed with one-sample t-test. A P-value plane (POC) values some differences compared to control group were found but they were not statistically significant (P=0.067) while for aterior occlusal plane (POA) no differences where noticed. This study revealed an increase in inter-jaw angle during treatment with FM and RPE, an increase in the inclination of the posterior occlusal plane with respect to the Frankfurt plane and a posterior and lower adaptation of the mandible.

  6. A comparison of Goldmann III, V and spatially equated test stimuli in visual field testing: the importance of complete and partial spatial summation.

    Science.gov (United States)

    Phu, Jack; Khuu, Sieu K; Zangerl, Barbara; Kalloniatis, Michael

    2017-03-01

    Goldmann size V (GV) test stimuli are less variable with a greater dynamic range and have been proposed for measuring contrast sensitivity instead of size III (GIII). Since GIII and GV operate within partial summation, we hypothesise that actual GV (aGV) thresholds could predict GIII (pGIII) thresholds, facilitating comparisons between actual GIII (aGIII) thresholds with pGIII thresholds derived from smaller GV variances. We test the suitability of GV for detecting visual field (VF) loss in patients with early glaucoma, and examine eccentricity-dependent effects of number and depth of defects. We also hypothesise that stimuli operating within complete spatial summation ('spatially equated stimuli') would detect more and deeper defects. Sixty normal subjects and 20 glaucoma patients underwent VF testing on the Humphrey Field Analyzer using GI-V sized stimuli on the 30-2 test grid in full threshold mode. Point-wise partial summation slope values were generated from GI-V thresholds, and we subsequently derived pGIII thresholds using aGV. Difference plots between actual GIII (aGIII) and pGIII thresholds were used to compare the amount of discordance. In glaucoma patients, the number of 'events' (points below the 95% lower limit of normal), defect depth and global indices were compared between stimuli. 90.5% of pGIII and aGIII points were within ±3 dB of each other in normal subjects. In the glaucoma cohort, there was less concordance (63.2% within ±3 dB), decreasing with increasing eccentricity. GIII found more defects compared to GV-derived thresholds, but only at outermost test locations. Greater defect depth was found using aGIII compared to aGV and pGIII, which increased with eccentricity. Global indices revealed more severe loss when using GIII compared to GV. Spatially equated stimuli detected the greatest number of 'events' and largest defect depth. Whilst GV may be used to reliably predict GIII values in normal subjects, there was less concordance in glaucoma

  7. Performance of a Rapid and Simple HIV Testing Algorithm in a Multicenter Phase III Microbicide Clinical Trial▿

    Science.gov (United States)

    Crucitti, Tania; Taylor, Doug; Beelaert, Greet; Fransen, Katrien; Van Damme, Lut

    2011-01-01

    A multitest sequential algorithm based on rapid and simple (R/S) assays was applied for the diagnosis of HIV infection among participants in a phase 3 microbicide effectiveness trial. HIV testing was performed on finger-prick blood samples obtained from patients after their enrollment in the trial. The specimens were tested in a serial procedure using three different rapid tests (Determine HIV-1/2 [Abbott], SD Bioline HIV-1/2 3.0 [Standard Diagnostics], and Uni-Gold HIV [Trinity Biotech]). In the event of discordant results between the Determine HIV-1/2 and SD Bioline HIV-1/2 3.0 tests, the third assay (Uni-Gold HIV) determined the final outcome. When the final outcome was positive, a second specimen was collected and tested with the same algorithm, only if a positive result was obtained with this sample the participant was informed of her positive serostatus. A total of 5,734 postenrollment specimens obtained from 1,398 women were tested. Forty-six women tested positive according to the testing algorithm performed on the first collected specimen. Confirmatory testing results obtained at the ITM confirmed that 42 women were truly infected. Two of four initial false positives tested negative upon analysis of a second blood specimen. The other two tested false positive twice using specimens collected the same day. A high percentage of specimens reactive with the Determine HIV-1/2 assay was only observed at the study site in Kampala. This result did not appear to be associated with pregnancy or malaria infection. We conclude that HIV testing algorithms, including only R/S assays, are suitable for use in clinical trials, provided that adequate quality assurance procedures are in place. PMID:21752945

  8. Performance of a rapid and simple HIV testing algorithm in a multicenter phase III microbicide clinical trial.

    Science.gov (United States)

    Crucitti, Tania; Taylor, Doug; Beelaert, Greet; Fransen, Katrien; Van Damme, Lut

    2011-09-01

    A multitest sequential algorithm based on rapid and simple (R/S) assays was applied for the diagnosis of HIV infection among participants in a phase 3 microbicide effectiveness trial. HIV testing was performed on finger-prick blood samples obtained from patients after their enrollment in the trial. The specimens were tested in a serial procedure using three different rapid tests (Determine HIV-1/2 [Abbott], SD Bioline HIV-1/2 3.0 [Standard Diagnostics], and Uni-Gold HIV [Trinity Biotech]). In the event of discordant results between the Determine HIV-1/2 and SD Bioline HIV-1/2 3.0 tests, the third assay (Uni-Gold HIV) determined the final outcome. When the final outcome was positive, a second specimen was collected and tested with the same algorithm, only if a positive result was obtained with this sample the participant was informed of her positive serostatus. A total of 5,734 postenrollment specimens obtained from 1,398 women were tested. Forty-six women tested positive according to the testing algorithm performed on the first collected specimen. Confirmatory testing results obtained at the ITM confirmed that 42 women were truly infected. Two of four initial false positives tested negative upon analysis of a second blood specimen. The other two tested false positive twice using specimens collected the same day. A high percentage of specimens reactive with the Determine HIV-1/2 assay was only observed at the study site in Kampala. This result did not appear to be associated with pregnancy or malaria infection. We conclude that HIV testing algorithms, including only R/S assays, are suitable for use in clinical trials, provided that adequate quality assurance procedures are in place.

  9. High-spin chloro mononuclear MnIII complexes: a multifrequency high-field EPR study.

    Science.gov (United States)

    Mantel, Claire; Chen, Hongyu; Crabtree, Robert H; Brudvig, Gary W; Pécaut, Jacques; Collomb, Marie-Noëlle; Duboc, Carole

    2005-03-01

    The isolation, structural characterization, and electronic properties of two six-coordinated chloromanganese (III) complexes, [Mn(terpy)(Cl)3] (1) and [Mn(Phterpy)(Cl)3] (2), are reported (terpy = 2,2':6'2"-terpyridine, Phterpy = 4'-phenyl-2,2':6',2"-terpyridine). These complexes complement a series of mononuclear azide and fluoride Mn(lll) complexes synthesized with neutral N-tridentate ligands, [Mn(L)(X)3] (X = F- or N3 and L = terpy or bpea [N,N-bis(2-pyridylmethyl)-ethylamine)], previously described. Similar to these previous complexes, 1 and 2 exhibit a Jahn-Teller distortion of the octahedron, characteristic of a high-spin Mn(III) complex (S = 2). The analysis of the crystallographic data shows that, in both cases, the manganese ion lies in the center of a distorted octahedron characterized by an elongation along the tetragonal axis. Their electronic properties were investigated by multifrequency EPR (190-475 GHz) performed in the solid state at different temperatures (5-15 K). This study confirms our previous results and further shows that: i) the sign of D is correlated with the nature of the tetragonal distortion; ii) the magnitude of D is not sensitive to the nature of the anions in our series of rhombic complexes, contrary to the porphyrinic systems; iii) the [E/D] values (0.124 for 1 and 0.085 for 2) are smaller compared to those found for the [Mn(L)(X)3] complexes (in the range of 0.146 to 0.234); and iv) the E term increases when the ligand-field strength of the equatorial ligands decreases.

  10. Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes.

    Science.gov (United States)

    Basha, Maram T; Bordini, Jeane; Richardson, Des R; Martinez, Manuel; Bernhardt, Paul V

    2016-09-01

    The oxidation of human oxyhemoglobin (HbO2) to methemoglobin (metHb) is an undesirable side effect identified in some promising thiosemicarbazone anti-cancer drugs. This is attributable to oxidation reactions driven by FeIII complexes of these drugs formed in vivo. In this work the FeIII complexes of selected 2-benzoylpyridine thiosemicarbazones (HBpT), 2-acetylpyridine thiosemicarbazones (HApT), and the clinically trialled thiosemicarbazone, Triapine® (3-amino-2-pyridinecarboxaldehyde thiosemicarbazone, H3-AP), have been studied. This was achieved by time-resolved UV-Visible absorption spectroscopy and the sequential oxidation of the α- and β-chains of HbO2 at distinctly different rates has been identified. A key structural element, namely a terminal -NH2 group on the thiosemicarbazone moiety, was found to be an important common feature of the most active HbO2 oxidising complexes that were investigated. Therefore, these studies indicate that an unsubstituted -NH2 moiety at the terminus of the thiosemicarbazone group should be avoided in the design of future compounds from this class. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Thiobiuret based Ni(II) and Co(III) complexes: Synthesis, molecular structures and DFT studies

    Science.gov (United States)

    Sherzaman, Saira; Sadiq-ur-Rehman; Ahmed, Muhammad Naeem; Khan, Bilal Ahmad; Mahmood, Tariq; Ayub, Khurshid; Tahir, Muhammad Nawaz

    2017-11-01

    Synthesis, molecular structures and DFT investigations of two new complexes of Ni(II) and Co(III) with (Z)-3-(3,3-dimethylbutanoyl)-1,1-diethyl-2-thiobiuret ligand are reported. Characterization of these complexes was achieved by spectroanalytical techniques (FT-IR, UV-vis and 1H NMR), and the structures were finally confirmed unequivocally by single crystal X-ray diffraction analysis. The obtained data of UV-vis, FT-IR and 1HNMR were compared with the literature values which satisfactorily confirmed the synthesis of ligand and their complexes. X-ray studies revealed the square planar and octahedral geometry of both Ni(II) and Co(III) complexes, respectively. Density functional theory (DFT) studies were performed to compare the theoretical results with experimental (X-ray as well as spectroanalytical) results, and good correlation was observed. Frontier molecular orbitals (FMOs) and molecular electrostatic potential (MEP) analyses revealed the reactivity and charge distribution in both complexes.

  12. Environmental test results for the CDV-711 Mark III and Model 2 remote-sensor radiation meters. Technical report, May 1968-October 1969

    Energy Technology Data Exchange (ETDEWEB)

    Groeber, E.O.; Lake, G.H.

    1970-01-01

    The Air Force has a stated requirement for an instrument to monitor the gamma radiation associated with a fallout environment and to be used Air Force wide in fallout shelters and command posts. The Office of Civil Defense (OCD) has developed two instruments, the CDv-711 Mark III, that could possibly satisfy the stated requirement. Both the Model 2 and the Mark III were operationally and environmentally tested to see if one of the instruments was suitable for Air Force use, either with or without additional engineering development.

  13. Time-resolved studies at PETRA III with a highly repetitive synchronized laser system

    Energy Technology Data Exchange (ETDEWEB)

    Schlie, Mortiz

    2013-09-15

    Atomic and molecular processes can nowadays be directly followed in the time domain. This is a core technique for a better understanding of the involved fundamental physics, thus auguring new applications in the future as well. Usually the so-called pump-probe technique making use of two synchronized ultrashort light pulses is utilized to obtain this time-resolved data. In this work, the development and characterization of a synchronization system enabling such pump-probe studies at the storage ring PETRA III in combination with an external, then synchronized fs-laser system is described. The synchronization is based on an extended PLL approach with three interconnected feedback loops allowing to monitor short-time losses of the lock and thus prevent them. This way, the jitter between the laser PHAROS and the PETRA III reference signal is reduced to {sigma} <5 ps. Thus the system allows to conduct experiments at a repetition rate of 130 kHz with a temporal resolution limited only by the X-ray pulse length. A major emphasis in the fundamental introductory chapters is an intuitive explanation of the basic principles of phase locked loops and the different aspects of phase noise to allow a deeper understanding of the synchronization. Furthermore, first pump-probe experiments conducted at different beamlines at PETRA III are presented, demonstrating the usability of the laser system in a scientific environment as well. In first characterizing experiments the pulse duration of PETRA III X-ray pulses has been measured to be 90 ps FWHM. In particular, there have been time resolved X-ray absorption spectroscopy experiments on Gaq3 and Znq2 conducted at beamline P11. First results show dynamics of the electronic excitation on the timescale of a few hundred pico seconds up to a few nano seconds and provide a basic understanding for further research on those molecules. For Gaq3 this data is analyzed in detail and compared with visible fluorescence measurements suggesting at

  14. Studies on the thermal decomposition of lanthanum(III) valerate and lanthanum(III) caproate in argon

    DEFF Research Database (Denmark)

    Grivel, Jean-Claude; Yue, Zhao; Suarez Guevara, Maria Josefina

    2015-01-01

    The decomposition of La-valerate (La(C4H9CO2)3·xH2O (x ≈ 0.45)) and La-caproate (La(C5H11CO2)3·xH2O (x ≈ 0.30)) was studied upon heating at 5 C/min in a flow of argon. Using a variety of techniques including simultaneous TG-DTA, FTIR, X-ray diffraction with both laboratory Cu Kα and synchrotron...

  15. Anticipating the clinical use of prognostic gene expression-based tests for colon cancer stage II and III: is Godot finally arriving?

    Science.gov (United States)

    Sveen, Anita; Nesbakken, Arild; Ågesen, Trude H; Guren, Marianne G; Tveit, Kjell M; Skotheim, Rolf I; Lothe, Ragnhild A

    2013-12-15

    According to current recommendations for adjuvant treatment, patients with colon cancer stage II are not routinely offered chemotherapy, unless considered to have a high risk of relapse based on specific clinicopathological parameters. Following these criteria, it is challenging to identify the subgroup of patients that will benefit the most from adjuvant treatment. Contrarily, patients with colon cancer stage III are routinely offered chemotherapy, but due to expected adverse effects and frailty, elderly patients are often excluded from standard protocols. Colon cancer is a disease of the elderly and accordingly, there is a large subgroup of patients for which guidelines for adjuvant treatment remain less clear. In these two clinical settings, improved risk stratification has great potential impact on patient care, anticipating that high-risk patients will benefit from chemotherapy. However, microsatellite instability is the only molecular prognostic marker recommended for clinical use. In this perspective, we provide an updated view on the status and clinical potential of the many proposed prognostic gene expression-based tests for colon cancer stage II and III. The main limitation for clinical implementation is lack of prospective validation. For patients with stage II, highly promising tests have been identified and clinical trials are ongoing. For elderly patients with stage III, the value of such tests has received less focus, but promising early results have been shown. Although awaiting results from prospective trials, improved risk assessment for patients with stage II and III is likely to be achieved in the foreseeable future. ©2013 AACR.

  16. Uptake Of Trivalent Actinides (Cm(III)) And Lanthanides (Eu(III)) By Cement-Type Minerals: A Wet Chemistry And Time-Resolved Laser Fluorescence Spectroscopy (TRLFS) Study

    Energy Technology Data Exchange (ETDEWEB)

    Tits, J.; Stumpf, T; Wieland, E.; Fanghaenel, T

    2003-03-01

    The interaction of the two chemical homologues Cm (III) and Eu(III) with calcium silicate hydrates at pH 13.3 has been investigated in batch-type sorption studies using Eu(III), and complemented with time-resolved laser fluorescence spectroscopy using Cm(III). The sorption data for Eu(III) reveal fast sorption kinetics, and a strong uptake by CSH phases, with distribution ratios of 6({+-}3)*105 L kg-1. Three different types of sorbed Cm(III) species have been identified: a non-fluorescing species, which was identified as Cm cluster present either as surface precipitate or as Cm(III) colloid in solution, and two sorbed fluorescing species. The sorbed fluorescing species have characteristic emission spectra (main peak maxima at 618.9 nm and 620.9 nm) and fluorescence emission lifetimes (289 {+-} 11 ms and 1482{+-} 200 ms). From the fluorescence lifetimes, it appears that the two fluorescing Cm(III) species have, respectively, one to two or no water molecules left in their first coordination sphere, suggesting that these species are incorporated into the CSH structure. A structural model for Cm(III) and Eu(III) incorporation into CSH phases is proposed based on the substitution of Ca at two different types of sites in the CSH structure. (author)

  17. Lanthanum(III) and Lutetium(III) in Nitrate-Based Ionic Liquids: A Theoretical Study of Their Coordination Shell.

    Science.gov (United States)

    Bodo, Enrico

    2015-09-03

    By using ab initio molecular dynamics, we investigate the solvent shell structure of La(3+) and Lu(3+) ions immersed in two ionic liquids, ethylammonium nitrate (EAN) and its hydroxy derivative (2-ethanolammonium nitrate, HOEAN). We provide the first study of the coordination properties of these heavy metal ions in such a highly charged nonacqueous environment. We find, as expected, that the coordination in the liquid is mainly due to nitrate anions and that, due to the bidentate nature of the ligand, the complexation shell of the central ion has a nontrivial geometry and a coordination number in terms of nitrate molecules that apparently violates the decrease of ionic radii along the lanthanides series, since the smaller Lu(3+) ion seems to coordinate six nitrate molecules and the La(3+) ion only five. A closer inspection of the structural features obtained from our calculations shows, instead, that the first shell of oxygen atoms is more compact for Lu(3+) than for La(3+) and that the former coordinates 8 oxygen atoms while the latter 10 in accord with the typical lanthanide's trend along the series and that their first solvation shells have a slight irregular and complex geometrical pattern. When moving to the HOEAN solutions, we have found that the solvation of the central ion is possibly also due to the cation itself through the oxygen atom on the side chain. Also, in this liquid, the coordination numbers in terms of oxygen atoms in both solvents is 10 for La(3+) and 8 for Lu(3+).

  18. A Statistical Study of Brown Dwarf Companions from the SDSS-III MARVELS Survey

    Science.gov (United States)

    Grieves, Nolan; Ge, Jian; Thomas, Neil; Ma, Bo; De Lee, Nathan M.; Lee, Brian L.; Fleming, Scott W.; Sithajan, Sirinrat; Varosi, Frank; Liu, Jian; Zhao, Bo; Li, Rui; Agol, Eric; MARVELS Team

    2016-01-01

    We present 23 new Brown Dwarf (BD) candidates from the Multi-object APO Radial-Velocity Exoplanet Large-Area Survey (MARVELS) of the Sloan Digital Sky Survey III (SDSS-III). The BD candidates were selected from the processed MARVELS data using the latest University of Florida 2D pipeline, which shows significant improvement and reduction of systematic errors over the 1D pipeline results included in the SDSS Data Release 12. This sample is the largest BD yield from a single radial velocity survey. Of the 23 candidates, 18 are around main sequence stars and 5 are around giant stars. Given a giant contamination rate of ~24% for the MARVELS survey, we find a BD occurrence rate around main sequence stars of ~0.7%, which agrees with previous studies and confirms the BD desert, while the BD occurrence rate around the MARVELS giant stars is ~0.6%. Preliminary results show that our new candidates around solar type stars support a two population hypothesis, where BDs are divided at a mass of ~42.5 MJup. BDs less massive than 42.5 MJup have eccentricity distributions consistent with planet-planet scattering models, where BDs more massive than 42.5 MJup have both period and eccentricity distributions similar to that of stellar binaries. Special Brown Dwarf systems such as multiple BD systems and highly eccentric BDs will also be presented.

  19. Synthesis, characterization and antibacterial studies of ruthenium(III) complexes derived from chitosan schiff base.

    Science.gov (United States)

    Vadivel, T; Dhamodaran, M

    2016-09-01

    Chitosan can be modified chemically by condensation reaction of deacetylated chitosan with aldehyde in homogeneous phase. This condensation is carried by primary amine (NH2) with aldehyde (CHO) to form corresponding schiff base. The chitosan biopolymer schiff base derivatives are synthesized with substituted aldehydes namely 4-hydroxy-3-methoxy benzaldehyde, 2-hydroxy benzaldehyde, and 2-hydroxy-3-methoxy benzaldehyde, becomes a complexing agent or ligand. The Ruthenium(III) complexes were obtained by complexation of Ruthenium with schiff base ligands and this product exhibits as an excellent solubility and more biocompatibility. The novel series of schiff base Ruthenium(III) complexes are characterized by Elemental analysis, FT-IR spectroscopy, and Thermo-gravimetric analysis (TGA). The synthesized complexes have been subjected to antibacterial study. The antibacterial results indicated that the antibacterial activity of the complexes were more effective against Gram positive and Gram negative pathogenic bacteria. These findings are giving suitable support for developing new antibacterial agent and expand our scope for applications. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Feasibility of transitioning from APACHE II to SAPS III as prognostic model in a Brazilian general intensive care unit. A retrospective study.

    Science.gov (United States)

    Serpa Neto, Ary; Assunção, Murillo Santucci Cesar de; Pardini, Andréia; Silva, Eliézer

    2015-01-01

    Prognostic models reflect the population characteristics of the countries from which they originate. Predictive models should be customized to fit the general population where they will be used. The aim here was to perform external validation on two predictive models and compare their performance in a mixed population of critically ill patients in Brazil. Retrospective study in a Brazilian general intensive care unit (ICU). This was a retrospective review of all patients admitted to a 41-bed mixed ICU from August 2011 to September 2012. Calibration (assessed using the Hosmer-Lemeshow goodness-of-fit test) and discrimination (assessed using area under the curve) of APACHE II and SAPS III were compared. The standardized mortality ratio (SMR) was calculated by dividing the number of observed deaths by the number of expected deaths. A total of 3,333 ICU patients were enrolled. The Hosmer-Lemeshow goodness-of-fit test showed good calibration for all models in relation to hospital mortality. For in-hospital mortality there was a worse fit for APACHE II in clinical patients. Discrimination was better for SAPS III for in-ICU and in-hospital mortality (P = 0.042). The SMRs for the whole population were 0.27 (confidence interval [CI]: 0.23 - 0.33) for APACHE II and 0.28 (CI: 0.22 - 0.36) for SAPS III. In this group of critically ill patients, SAPS III was a better prognostic score, with higher discrimination and calibration power.

  1. Fulvic acid complexation of Eu(III) and Cm(III) at elevated temperatures studied by time-resolved laser fluorescence spectroscopy.

    Science.gov (United States)

    Fröhlich, Daniel R; Skerencak-Frech, Andrej; Gast, Michael; Panak, Petra J

    2014-11-07

    The interaction of Eu(III) and Cm(III) with three different aquatic fulvic acids (FA) was studied as a function of the temperature (T = 20-80 °C) in 0.1 M NaCl solution by time-resolved laser fluorescence spectroscopy. The speciation of both trivalent metal ions was determined by peak deconvolution of the recorded fluorescence spectra. For each studied metal ion-FA system only one complexed species is formed under the given experimental conditions. The stability constants at 20, 40, 60 and 80 °C (log β'(T)) were determined according to the charge neutralization model. The log β' (20 °C) for the different FAs show similar values (log β(20 °C) = 5.60-6.29). The stability constants increase continuously with increasing temperature by approximately 0.3-1.0 orders of magnitude. The reaction enthalpies and entropies are derived from the integrated Van't Hoff equation. The results show that all investigated complexation reactions are endothermic and entropy-driven.

  2. Methodological Factors in Determining Risk of Dementia After Transient Ischemic Attack and Stroke: (III) Applicability of Cognitive Tests.

    Science.gov (United States)

    Pendlebury, Sarah T; Klaus, Stephen P; Thomson, Ross J; Mehta, Ziyah; Wharton, Rose M; Rothwell, Peter M

    2015-11-01

    Cognitive assessment is recommended after stroke but there are few data on the applicability of short cognitive tests to the full spectrum of patients. We therefore determined the rates, causes, and associates of untestability in a population-based study of all transient ischemic attack (TIA) and stroke. Patients with TIA or stroke prospectively recruited (2002-2007) into the Oxford Vascular Study had ≥1 short cognitive test (mini-mental state examination, telephone interview of cognitive status, Montreal cognitive assessment, and abbreviated mental test score) at baseline and on follow-up to 5 years. Among 1097 consecutive assessed survivors (mean: age/SD, 74.8/12.1 years; 378 TIA), numbers testable with a short cognitive test at baseline, 1, 6, 12, and 60 months were 835/1097 (76%), 778/947 (82%), 756/857 (88%), 692/792 (87%), and 472/567 (83%). Eighty-eight percent (331/378) of assessed patients with TIA were testable at baseline compared with only 46% (133/290) of major stroke (Pcaused by acute stroke effects at baseline (153/262 [58%]: dysphasia/anarthria/hemiparesis=84 [32%], drowsiness=58 [22%], and acute confusion=11 [4%]), whereas sensory deficits caused relatively more problems with testing at later time points (24/63 [38%] at 5 years). Substantial numbers of patients with TIA and stroke are untestable with short cognitive tests. Future studies should report data on untestable patients and those with problems with testing in whom the likelihood of dementia is high. © 2015 American Heart Association, Inc.

  3. Synthesis, structural characterization, luminescent properties and theoretical study of three novel lanthanide metal-organic frameworks of Ho(III), Gd(III) and Eu(III) with 2,5-thiophenedicarboxylate anion

    Energy Technology Data Exchange (ETDEWEB)

    Marques, Lippy F. [Instituto de Química, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-013 (Brazil); Correa, Charlane C. [Departamento de Química-ICE, Universidade Federal de Juiz de Fora, Juiz de Fora-MG, 36036-330 (Brazil); Ribeiro, Sidney J.L.; Santos, Molíria V. dos [Institute of Chemistry, São Paulo State University − UNESP, CP 355 Araraquara-SP 14801-970 Brazil (Brazil); Dutra, José Diogo L.; Freire, Ricardo O. [Pople Computational Chemistry Laboratory, Departamento de Química, Universidade Federal de Sergipe, São Cristóvão-SE 49100-000 (Brazil); Machado, Flávia C., E-mail: flavia.machado@ufjf.edu.br [Departamento de Química-ICE, Universidade Federal de Juiz de Fora, Juiz de Fora-MG, 36036-330 (Brazil)

    2015-07-15

    In this paper, the synthesis of three new metal-organic frameworks of lanthanides (LnMOFs) ([Ln{sub 2}(2,5-tdc){sub 3}(dmso){sub 2}]·H{sub 2}O){sub n} (Ln=Ho (1); Gd (2); Eu (3); 2,5-tdc=2,5-thiophenedicarboxylate anion; dmso=dimethylsulfoxide), and their complete characterization, including single crystal X-ray diffraction, FTIR spectroscopy and thermogravimetric analysis are reported. In especial, photophysical properties of Eu(III) complex have been studied in detail via both theoretical and experimental approaches. Crystal structure of (1) reveals that each lanthanide ion is seven-coordinated by oxygen atoms in an overall distorted capped trigonal – prismatic geometry. The 2,5-tdc{sup 2−} ligands connect four Ln(III) centers, adopting (κ{sup 1}–κ{sup 1})–(κ{sup 1}–κ{sup 1})–μ{sub 4} coordination mode, generating an 8-connected uninodal 3D network. In addition, theoretical studies for Eu(III) complex were performed using the Sparkle model for lanthanide complexes. - Graphical abstract: Three new metal-organic frameworks of lanthanides (LnMOFs) ([Ln{sub 2}(2,5-tdc){sub 3}(dmso){sub 2}]·H{sub 2}O){sub n} (Ln=Ho (1); Gd (2); Eu (3); 2,5-tdc=2,5-thiophenedicarboxylate anion; dmso=dimethylsulfoxide), were synthesized and their complete characterization, including single crystal X-ray diffraction, FTIR spectroscopy and thermogravimetric analysis are reported. In especial, photophysical properties of Eu(III) complex have been studied in detail via both theoretical and experimental approaches. - Highlights: • Three new LnMOFs were synthesized and fully characterized. • Ho{sup 3+}, Gd{sup 3+} and Eu{sup 3+} complexes photoluminescence properties were investigated. • Theoretical approaches for Eu{sup 3+} complex luminescence has been performed. • An energy level diagram is used to establish the ligand-to-metal energy transfer. • These metal−organic frameworks can act as light conversion molecular devices.

  4. A Study Of The Signs By Meaning In The Elegy Written By Ayni For Selim III

    Directory of Open Access Journals (Sweden)

    Behice Varışoğlu

    2010-12-01

    Full Text Available In this study, the content and style of the elegy that is written for Selim III by Ayni from Antep who is one of the poets of 18th century is analyzed through the meaning. In this analysis, it is used from the method of classical interpretation that is constantly used for explanation of Ottoman poetry and method of semiology and semantics. At the same time, it is focused on the meaning of some of the special words in the poet which is described as signs. As a result, in this poem, it is determined that the context which is between expression and meaning is composed through rhetoric and adjectives and the relationship of style and content is provided by rhyme and redif and repeat of sound and word

  5. Fuji III vs. Fuji VII glass ionomer sealants--a clinical study.

    Science.gov (United States)

    Kamala, B K; Hegde, Amitha M

    2008-01-01

    Glass ionomer cements possess several properties that support their consideration in a wide variety of clinical applications including Pit and fissure sealants. The aim of this study was to compare and evaluate Fuji III and Fuji VII glass ionomer sealants in terms of retention, caries incidence and salivary fluoride release between two groups of children aged 6 and-8 years respectively. One hundred and ten first permanent molars were sealed and the clinical evaluation showed no incidence of caries. There was partial or complete retention of the sealant in 80% of the treated teeth in both groups at the one-year evaluation. Irrespective of the sealant used, the pattern of fluoride release remained consistent, with an initial high fluoride release followed by low prolonged leakage before returning to baseline value at the end of one year.

  6. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases

    Science.gov (United States)

    Ejidike, Ikechukwu P.

    2016-01-01

    Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl2(H2O)] showed the highest activity with IC50 valves of 3.57 ± 1.09, 6.44 ± 0.38, and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)]. PMID:27597814

  7. What do women think about abnormal smear test results? A qualitative interview study.

    NARCIS (Netherlands)

    Lagro-Janssen, A.L.M.; Schijf, C.P.T.

    2005-01-01

    The aim of the study is a report of Dutch women's views on abnormal cervical smear test results and the consequences thereof. Twenty-seven women with recent PAP III in their history were interviewed in the context of this qualitative study. GPs often do not inform patients beforehand about the ways

  8. Samarium(III) picrate tetraethylene glycol complex: Photoluminescence study and active material in monolayer electroluminescent

    Energy Technology Data Exchange (ETDEWEB)

    Kusrini, Eny, E-mail: ekusrini@che.ui.ac.id [Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, 16424 Depok (Indonesia); Saleh, Muhammad I. [School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang (Malaysia); Yulizar, Yoki [Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, 16424 Depok (Indonesia); Za' aba, Noor K.; Abd. Majid, W.H. [Solid State Research Laboratory, Department of Physics, Universiti Malaya, 50603 Kuala Lumpur (Malaysia)

    2011-09-15

    A mononuclear Sm(III) complex involving Pic and EO4 (where Pic=picrate anion and EO4=tetraethylene glycol) has been studied. It shows a bright-orange emission when used as active material in a monolayer electroluminescent device of ITO/EO4-Sm-Pic/Al. The crystal structure of the complex consists of [Sm(Pic){sub 2}(H{sub 2}O)(EO4)]{sup +} cation and [Pic]{sup -} anion. The Sm(III) ion is coordinated with nine oxygen atoms from one EO4 ligand in a pentadentate mode, two Pic anions each in bidentate and monodentate modes, and one water molecule. Both the terminal alcohol groups of the acyclic EO4 ligand were involved in the O-H...O hydrogen bonding by infinite one-dimensional (1D) chain within a symmetry direction [0 1 0]. The photoluminescence (PL) spectrum of the thin film shows the typical spectral features of the Sm(III) ion ({sup 4}G{sub 5/2}{yields}{sup 6}H{sub 7/2} transitions). The root-mean-square (rms) of the roughness of thin film is 30.605 nm and indicates that the formation of the monolayer electroluminescent device is not uniform and retains a high crystallinity. Typical semiconductor current-voltage (I-V) property was also observed in this device with threshold and turn voltages of 2.8 and 6.2 V, respectively. The [Sm(Pic){sub 2}(H{sub 2}O)(EO4)](Pic).H{sub 2}O complex can be applied as a luminescent center in OLED for bright-orange emission. - Highlights: > The [Sm(Pic){sub 2}(H{sub 2}O)(EO4)](Pic).H{sub 2}O complex is crystallized in triclinic with space group P-1. > The complex is applied as a emissive center in monolayer device structure of ITO/EO4-Sm-Pic/Al. > The photoluminescence spectrum of the crystalline and thin film shows a bright-orange emission. > The current-voltage property showed the turn on voltage of 6.2 V.

  9. Synthesis, Characterization, and Antifungal Studies of Cr(III) Complex of Norfloxacin and Bipiridyl Ligand

    National Research Council Canada - National Science Library

    Debnath, Anamika; Hussain, Firasat; Masram, Dhanraj T

    2014-01-01

    A novel slightly distorted octahedral complex of Cr(III) of norfloxacin (Nor) with the formula [Cr(III)(Nor)(Bipy)Cl2]Cl·2CH3OH has been synthesized hydrothermally in the presence of a N-containing heterocyclic compound 2,2'-bipyridyl...

  10. First level analysis report: comparative testing of HVS Mk IV+ and HVS Mk III on road D2388 near Cullinan

    CSIR Research Space (South Africa)

    Morton, B

    2003-03-01

    Full Text Available After many years of owning and operating a Heavy Vehicle Simulator (HVS) Mk III, Gautrans acquired a HVS Mk IV+ in May 2002. In addition to the advanced features that this machine possesses in comparison to its predecessor, the HVS Mk IV+ also has...

  11. Structural and spectroscopic studies of [bis(picrato)(pentaethylene glycol)lanthanide(III)] picrate complexes with Ln(III) = Sm, Dy and Ho

    Science.gov (United States)

    Saleh, Muhammad I.; Kusrini, Eny; Adnan, Rohana; Saad, Bahruddin; Yamin, Bohari M.; Fun, Hoong K.

    2007-06-01

    The Sm(III), Dy(III) and Ho(III) complexes with mixed pentaethylene glycol (EO5) and picrate (Pic -) ligands were obtained and characterized by elemental analysis, IR, 1H and 13C NMR spectroscopic techniques. They are isostructural with general formula of [Ln(Pic) 2(EO5)] +(Pic) - (Ln = Sm(III), Dy(III) and Ho(III)). X-ray investigations showed that all the three complexes consist of hexadentate EO5 ligand and two picrate anions, one chelated in bidentate manner and the other one is monodentate located on the opposite sides of the primary Ln1-EO5 coordination sphere in a nine coordination environment. The geometry of the Ln1-EO5 sphere is tricapped trigonal prismatic with both benzene rings almost vertical to each other. TGA spectra of the complexes showed a gradual decomposition started from 250 °C followed by a sharp decrease in weight loss at 265 °C.

  12. The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute⊕ Study

    Directory of Open Access Journals (Sweden)

    Pruijt Hans FM

    2011-05-01

    Full Text Available Abstract Background The presence of lymph node metastases remains the most reliable prognostic predictor and the gold indicator for adjuvant treatment in colon cancer (CC. In spite of a potentially curative resection, 20 to 30% of CC patients testing negative for lymph node metastases (i.e. pN0 will subsequently develop locoregional and/or systemic metastases within 5 years. The presence of occult nodal isolated tumor cells (ITCs and/or micrometastases (MMs at the time of resection predisposes CC patients to high risk for disease recurrence. These pN0micro+ patients harbouring occult micrometastases may benefit from adjuvant treatment. The purpose of the present study is to delineate the subset of pN0 patients with micrometastases (pN0micro+ and evaluate the benefits from adjuvant chemotherapy in pN0micro+ CC patients. Methods/design EnRoute+ is an open label, multicenter, randomized controlled clinical trial. All CC patients (age above 18 years without synchronous locoregional lymph node and/or systemic metastases (clinical stage I-II disease and operated upon with curative intent are eligible for inclusion. All resected specimens of patients are subject to an ex vivo sentinel lymph node mapping procedure (SLNM following curative resection. The investigation for micrometastases in pN0 patients is done by extended serial sectioning and immunohistochemistry for pan-cytokeratin in sentinel lymph nodes which are tumour negative upon standard pathological examination. Patients with ITC/MM-positive sentinel lymph nodes (pN0micro+ are randomized for adjuvant chemotherapy following the CAPOX treatment scheme or observation. The primary endpoint is 3-year disease free survival (DFS. Discussion The EnRoute+ study is designed to improve prognosis in high-risk stage I/II pN0 micro+ CC patients by reducing disease recurrence by adjuvant chemotherapy. Trial Registration ClinicalTrials.gov: NCT01097265

  13. LNG cascading damage study. Volume I, fracture testing report.

    Energy Technology Data Exchange (ETDEWEB)

    Petti, Jason P.; Kalan, Robert J.

    2011-12-01

    As part of the liquefied natural gas (LNG) Cascading Damage Study, a series of structural tests were conducted to investigate the thermal induced fracture of steel plate structures. The thermal stresses were achieved by applying liquid nitrogen (LN{sub 2}) onto sections of each steel plate. In addition to inducing large thermal stresses, the lowering of the steel temperature simultaneously reduced the fracture toughness. Liquid nitrogen was used as a surrogate for LNG due to safety concerns and since the temperature of LN{sub 2} is similar (-190 C) to LNG (-161 C). The use of LN{sub 2} ensured that the tests could achieve cryogenic temperatures in the range an actual vessel would encounter during a LNG spill. There were four phases to this test series. Phase I was the initial exploratory stage, which was used to develop the testing process. In the Phase II series of tests, larger plates were used and tested until fracture. The plate sizes ranged from 4 ft square pieces to 6 ft square sections with thicknesses from 1/4 inches to 3/4 inches. This phase investigated the cooling rates on larger plates and the effect of different notch geometries (stress concentrations used to initiate brittle fracture). Phase II was divided into two sections, Phase II-A and Phase II-B. Phase II-A used standard A36 steel, while Phase II-B used marine grade steels. In Phase III, the test structures were significantly larger, in the range of 12 ft by 12 ft by 3 ft high. These structures were designed with more complex geometries to include features similar to those on LNG vessels. The final test phase, Phase IV, investigated differences in the heat transfer (cooling rates) between LNG and LN{sub 2}. All of the tests conducted in this study are used in subsequent parts of the LNG Cascading Damage Study, specifically the computational analyses.

  14. Human DPP III – Keap1 Interactions: A Combined Experimental And Computational study

    Directory of Open Access Journals (Sweden)

    Mario Gundić

    2016-06-01

    Full Text Available Kelch-like ECH associated protein 1 (Keap1 is a cellular sensor for oxidative stress and a negative regulator of the transcription factor Nrf2. Keap1 and Nrf2 control expression of nearly 500 genes with diverse cytoprotective functions and the Nrf2-Keap1 signaling pathway is a major regulator of cytoprotective responses to oxidative and electrophilic stress. It was found that the metallopeptidase dipeptidyl peptidase III (DPP III contributes to Nrf2 activation by binding to Keap1, probably by binding to the Kelch domain, and thereby influences Nrf2 activity in cancer. We here first determined that the KD of the DPP III-Kelch domain complex is in the submicromolar range. In order to elucidate the molecular details of the DPP III – Kelch interaction we then built models of the complex between human DPP III and the Keap1 Kelch domain and performed coarse-grained and atomistic simulations of the complexes. In the most stable complexes, the ETGE motif in the DPP III flexible loop binds near the central pore of the six-blade β-propeller Kelch domain. According to the preliminary HD exchange experiments DPP III binds to the more unstructured end of Kelch domain. According to the results of MD simulations DPP III binding to the Kelch domain does not influence the overall DPP III structure or the long-range domain fluctuations. We can conclude that DPP III forms the stable complexes with the Keap1 Kelch domain by inserting the flexible loop into the entrance to the central pore of the six blade β-propeller Kelch domain at its more unstructured, N-terminus. This work is licensed under a Creative Commons Attribution 4.0 International License.

  15. Study of Adsorption Property of Ga(III) onto Strongly Basic Resin for Ga Extraction from Bayer Liquor

    Science.gov (United States)

    Zhao, Zhuo; Yang, Yongxiang; Lu, Hao; Hua, Zhongsheng; Ma, Xiaoling

    Ion-exchange is the main technology used in industry for gallium recovery from Bayer liquor, the largest gallium production resource. However, the co-extraction of vanadium and the degradation of resins are the major issues. Further investigations related to fundamental theory are needed. This paper reports the study of the adsorption properties of a strongly basic resin having a combination of one =NOH group and another active group -NH2 for Ga(III) extraction. The influence of operational conditions such as contact time, initial Ga(III) concentration and temperature on Ga(III) adsorption were extensively investigated. The results revealed that the resin has high adsorption capacity and Ga(III) selectivity. The optimal adsorption condition was obtained at temperatures of 40-50°C and contact time of 40-60 min. The Ga(III) adsorption data on the resin fit well with the pseudo second-order kinetics. Langmuir and Freundlich models were used to describe Ga(III) adsorption isotherms on the resin.

  16. Luminescence study of lanthanide(III) ions in non-aqueous solutions containing azide ions

    Energy Technology Data Exchange (ETDEWEB)

    Lis, S.; Kimura, T.; Yoshida, Z.; But, S

    2004-10-20

    Luminescence lifetime and intensity measurements of lanthanide(III) ions, Ln{sup 3+} (Eu, Gd and Tb), in non-aqueous solutions containing azide ions (N{sub 3}{sup -}) have been performed to study the quenching effect of N{sub 3}{sup -} using time-resolved laser-induced luminescence spectroscopy and conventional luminescence spectroscopy. The luminescence Stern-Volmer quenching constants K{sub sv}{sup P}HI and azide non-radiative decay constants k{sub N{sub 3}} of the excited Eu(III) ion in the presence of N{sub 3}{sup -} were measured in N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), N-methylformamide (NMF), formamide (FA) and methanol (MeOH). The obtained quenching effect of the Ln{sup 3+} luminescence by azide in the non-aqueous solvents shows the order: Gd>Eu>Tb, which does not obey the energy gap law, {delta}E, between the emitting and the ground state of the Ln{sup 3+} ion (Gd>Tb>Eu). The anomaly in the quenching pattern observed in the case of Eu{sup 3+} can be attributed to its partial reduction to Eu{sup 2+}, additionally to the energy transfer from excited state of Eu{sup 3+} to N{sub 3}{sup -}. The values of quenching rate constants k{sub N{sub 3}} measured for Eu{sup 3+} in various solutions depend on the acceptor number (AN) of the solvents used.

  17. An aerodynamic study of labial stop consonants after laser cordectomy of types II-III.

    Science.gov (United States)

    Wallet, Lucille

    2015-03-01

    The aim of this paper is to compare the aerodynamic parameters of intraoral pressure (IOP), oral airflow (OAF), and estimated transglottal pressure of 10 French patients treated by a cordectomy of types II-III with a group of 10 French healthy subjects. Prospective. The collection of the aerodynamic data was conducted with EVA2. Parameters were measured using logatomes of the type CV1·CV2·CVC3 where C represents [p,b] and V is one of the vowels [a,i,u] in the positions one and two (n = 240). The maximum peaks of IOP of the plosives [p] and [b] and the maximum peaks of OAF at their releases were extracted. Finally, the transglottal pressure was estimated, necessary for the voicing of [b], to establish the difference in the IOP mean peak of [p] and [b] at the same intensity. Subsequently, the differences in IOP for both positions and each vocalic contexts, "IOP(p-b)" were calculated, and the reports of these differences for the IOP of [p], viz "IOP(p-b)/IOP(p)", were established for a normalization of the results. This study highlights an increase of the IOP and the OAF in voiceless contexts for both groups. The elevation of both parameters observed for the patients-confirmed by the calculation of the estimated transglottal pressure-does show some degree of laryngeal incompetence. The patients treated by cordectomy of types II-III maintain a relatively good voicing contrast. A certain difficulty in the execution of this articulatory feature is found. Copyright © 2015 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  18. Evaluation of the MOZAIC Capacitive Hygrometer during the airborne field study CIRRUS-III

    Science.gov (United States)

    Neis, P.; Smit, H. G. J.; Krämer, M.; Spelten, N.; Petzold, A.

    2015-03-01

    The MOZAIC Capacitive Hygrometer (MCH) is usually operated aboard passenger aircraft in the framework of MOZAIC (Measurement of Ozone by Airbus In-Service Aircraft) for measuring atmospheric relative humidity (RH). In order to evaluate the performance of the MCH, the instrument was operated aboard a Learjet 35A research aircraft as part of the CIRRUS-III field study together with a closed-cell Lyman-α fluorescence hygrometer (Fast in situ Stratospheric Hygrometer, or FISH) and an open-path tunable diode laser system (Open-path Jülich Stratospheric TDL ExpeRiment, or OJSTER) for water vapour measurement. After reducing the CIRRUS-III data set to data corresponding to MOZAIC aircraft operation conditions, the 1 Hz RH data cross correlation between the MCH and reference instruments FISH (clear sky) and OJSTER (in-cirrus) yielded a remarkably good agreement of R2 = 0.92 and slope m = 1.02 and provided a MCH uncertainty of 5% RH. Probability distribution functions of RH deduced from the MCH and reference instruments agreed well between 10 and 70% RH with respect to liquid water in the ambient temperature range of ca. -70 to -40 °C. The use of MCH data is limited to sensor temperatures above the calibration limit of Tsensor = -40 °C (corresponds to ambient temperature of Tambient = -70 °C at typical cruising speed of long-haul passenger aircraft). Good performance of the MCH for clear sky as well as for in-cirrus conditions demonstrated the sensor robustness also for operation inside ice clouds.

  19. Verification Test of the SURF and SURFplus Models in xRage: Part III Affect of Mesh Alignment

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-15

    The previous studies used an underdriven detonation wave in 1-dimension (steady ZND reaction zone profile followed by a scale-invariant rarefaction wave) for PBX 9502 as a verification test of the implementation of the SURF and SURFplus models in the xRage code. Since the SURF rate is a function of the lead shock pressure, the question arises as to the effect on accuracy of variations in the detected shock pressure due to the alignment of the shock front with the mesh. To study the effect of mesh alignment we simulate a cylindrically diverging detonation wave using a planar 2-D mesh. The leading issue is the magnitude of azimuthal asymmetries in the numerical solution. The 2-D test case does not have an exact analytic solution. To quantify the accuracy, the 2-D solution along rays through the origin are compared to a highly resolved 1-D simulation in cylindrical geometry.

  20. Parameterized study of the test cover problem

    DEFF Research Database (Denmark)

    Crowston, Robert; Gutin, Gregory; Jones, Mark

    2012-01-01

    In this paper we carry out a systematic study of a natural covering problem, used for identification across several areas, in the realm of parameterized complexity. In the Test Cover problem we are given a set [n] = {1,...,n} of items together with a collection, , of distinct subsets of these items...... called tests. We assume that is a test cover, i.e., for each pair of items there is a test in containing exactly one of these items. The objective is to find a minimum size subcollection of , which is still a test cover. The generic parameterized version of Test Cover is denoted by -Test Cover. Here, we...... are given and a positive integer parameter k as input and the objective is to decide whether there is a test cover of size at most . We study four parameterizations for Test Cover and obtain the following: (a) k-Test Cover, and (n - k)-Test Cover are fixed-parameter tractable (FPT), i.e., these problems can...

  1. The oxidation of chromium(III) by hydroxyl radical in alkaline solution. A stopped-flow and pre-mix pulse radiolysis study

    DEFF Research Database (Denmark)

    Zhao, Zhongwei; Rush, J.D.; Holcman, J.

    1995-01-01

    The pK(a) for the equilibrium Cr(III)(H2O)3(OH)3(OH)3 reversible Cr(III)(H2O)2(OH)4- + H+ was determined to be 12.8 at 25-degrees-C. The dimerization of the two monomeric forms was studied in alkaline solutions using the stopped-flow method: k2[Cr(III)(H2O)3(OH)3 + Cr(III)(H2O)3(OH)3] = (2.5 +/- ...

  2. Sorption of Eu(III) on granite: EPMA, LA-ICP-MS, batch and modeling studies.

    Science.gov (United States)

    Fukushi, Keisuke; Hasegawa, Yusuke; Maeda, Koushi; Aoi, Yusuke; Tamura, Akihiro; Arai, Shoji; Yamamoto, Yuhei; Aosai, Daisuke; Mizuno, Takashi

    2013-11-19

    Eu(III) sorption on granite was assessed using combined microscopic and macroscopic approaches in neutral to acidic conditions where the mobility of Eu(III) is generally considered to be high. Polished thin sections of the granite were reacted with solutions containing 10 μM of Eu(III) and were analyzed using EPMA and LA-ICP-MS. On most of the biotite grains, Eu enrichment up to 6 wt % was observed. The Eu-enriched parts of biotite commonly lose K, which is the interlayer cation of biotite, indicating that the sorption mode of Eu(III) by the biotite is cation exchange in the interlayer. The distributions of Eu appeared along the original cracks of the biotite. Those occurrences indicate that the prior water-rock interaction along the cracks engendered modification of biotite to possess affinity to the Eu(III). Batch Eu(III) sorption experiments on granite and biotite powders were conducted as functions of pH, Eu(III) loading, and ionic strength. The macroscopic sorption behavior of biotite was consistent with that of granite. At pH > 4, there was little pH dependence but strong ionic strength dependence of Eu(III) sorption. At pH 4 was reproducible reasonably by the modeling considering single-site cation exchange reactions. The decrease of Eu(III) sorption at pH < 4 was explained by the occupation of exchangeable sites by dissolved cationic species such as Al and Fe from granite and biotite in low-pH conditions. Granites are complex mineral assemblages. However, the combined microscopic and macroscopic approaches revealed that elementary reactions by a single mineral phase can be representative of the bulk sorption reaction in complex mineral assemblages.

  3. Studies of inclusion complexes between cyclodextrins and polyazamacrocyclic chelates of lanthanide (III) ions[Binding equilibria; Titration calorimetry; Molecular dynamics; Lanthanide (III) chelates of polyazamacrocycles; {gamma}-Cyclodextrin

    Energy Technology Data Exchange (ETDEWEB)

    Henriques, Elsa S.; Bastos, Margarida E-mail: mbastos@fc.up.pt; Geraldes, Carlos F.G.C.; Ramos, Maria Joao

    2003-10-01

    The complexes between {gamma}-cyclodextrin and lanthanide (III) chelates of the polyazamacrocycles DOTA (DOTA {identical_to} 1,4,7,10-tertraazacyclododecane-1,4,7,10-tetraacetate) and DOTP (DOTP {identical_to} 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonate) have been thought out to enhance the potential of such chelates as contrast agents for MRI. Given the actual demand for the design of new contrast agents, we thought it worthwhile to confirm previous results for the equilibrium constant K obtained by one of us by NMR on the DOTP complex, as well as to determine K for a new one with DOTA. Further, we wanted to study and quantify the interactions present in these complexes, with a view to improve them in newly designed complexes. The interactions between {gamma}-cyclodextrin and the lanthanide (III)-polyazamacrocyclic chelates, [Tm(DOTP)]{sup 5-}, and [Gd(DOTA)]{sup -} were then studied by isothermal calorimetry (ITC) and molecular dynamics. The calorimetric experiments can be interpreted by considering that in both cases there is a weak association, characterized by low values for the equilibrium constant as well as for the molar enthalpy change for complex formation, at T=298.15 K. The K value for the complex with DOTP obtained now by ITC is of the same order of magnitude of the one determined previously by NMR. Further, the complex formation seems rather insensitive to the macrocycle, as the values now obtained by ITC for the DOTA complex are very similar to the ones obtained for the DOTP complex. We have also carried out molecular dynamics simulations on these very same inclusion complexes, which provided quantitative data on the interactions present, as well as a plausible explanation for the data obtained, leading to the proposal of possible solutions to improve the modelling of new contrast agents on a host-guest basis.

  4. ARIC hemostasis study--III. Quality control. Atherosclerosis Risk in Communities.

    Science.gov (United States)

    Chambless, L E; McMahon, R; Finch, A; Sorlie, P; Heiss, G; Lyles, R; Wu, K K

    1993-10-18

    Methods and results from the quality assurance program of the Atherosclerosis Risk in Communities (ARIC) Study regarding hemostasis variables are presented, following up previous reports in this journal on standardized procedures for blood collection and processing (7) and an organized plan for the performance of those procedures (8). Efforts were made to control for and assess all sources of variability, from venipuncture to laboratory analysis, including also local field center processing and sample shipping. The quality control program included (a) a standardized protocol for blood collection and processing; (b) training, certification, and annual recertification of field center personnel for blood collection and processing; (c) monitoring of fasting times, phlebotomy times, processing times, and shipping problems; (d) hemostatic laboratory internal quality control; (e) a replicate blood sample program; (f) an intraindividual variability study; and (g) continual monitoring of quality control and study participants' data. This paper focused on items (c), (d), and (e). Measures of variation, generally standard deviations and coefficients of variation, are estimated for replicate blood sampling and internal quality control data, for activated partial thromboplastin time, fibrinogen, factor VII and VIII activity, von Willebrand factor, antithrombin-III, and protein C. The results demonstrate that it is possible to reliably measure these hemostatic variables in a large multicenter study.

  5. Study on the interaction of Co (III) DiAmsar with serum albumins: Spectroscopic and molecular docking methods

    Science.gov (United States)

    Farahani, Bahman Vasheghani; Bardajee, Ghasem Rezanejade; Rajabi, Farzaneh Hosseinpour; Hooshyar, Zari

    2015-01-01

    This study was designed to examine the interaction of cobalt-3,6,10,13,16,19-hexaazabicyclo[6.6.6]eicosane-1,8-diamine (Co(III) DiAmsar) as a hexadentate ligand with human serum albumin (HSA) and bovine serum albumin (BSA) under physiological conditions in Tris-HCl buffer solution at pH 7.4. To this aim, at first, Co (III) DiAmsar was synthesized and characterized by nuclear magnetic resonance (NMR), and mass spectroscopy and then its interaction with HSA and BSA was investigated by means of various spectroscopic methods (Fourier transform infrared (FT-IR), UV-visible (UV-vis), fluorescence, and cyclic voltammetry (CV)) and molecular docking technique. The results of fluorescence titration revealed that the Co (III) DiAmsar strongly quench the intrinsic fluorescence of HSA and BSA through a static quenching procedure. Binding constants (Ka) and the number of binding sites (n ∼ 1) were calculated using Stern-Volmer equations. The ΔG parameters at different temperatures were calculated. Subsequently, the values of ΔH and ΔS were also calculated, which revealed that the van der Waals and hydrogen bonding interaction splay a major role in Co (III) DiAmsar-HSA and Co (III) DiAmsar-BSA associations. The distance r between donor (HSA and BSA) and acceptor (Co (III) DiAmsar) was obtained according to fluorescence resonance energy transfer. The data obtained by the molecular modeling study revealed the surrounding residues of HSA and BSA around Co (III) DiAmsar.

  6. Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing

    Directory of Open Access Journals (Sweden)

    Bappaditya Dey

    2013-01-01

    effective vaccine will stop the growth of developing tubercles before while they are still microscopic in size. Unfortunately, rabbits are rarely used in preclinical vaccine trials, despite their relative ease of handling and human-like response to this infection. Mice do not generate an effective DTH response, and guinea pigs do not generate an effective CMI response. Only the rabbits and most humans can establish the proper amount of DTH and CMI that is necessary to contain this infection. Therefore, rabbits should be included in all pre-clinical testing of new TB vaccines. New drugs (and/or immunological procedures to reduce liquefaction and cavity formation are urgently needed. A simple intradermal way to select such drugs or procedures is described herein. Part III. Clinical Testing. Vaccine trials would be much more precise if the variations in human populations (listed herein were taken into consideration. BCG and successful new TB vaccines should always increase host resistance to TB in naive subjects. This is a basic immunological principle. The efficacies of new and old TB vaccines are often not recognized, because these variations were not identified in the populations evaluated.

  7. Antioxidant, tautomerism and antibacterial studies of Fe(III)-1,2,4-triazole based complexes

    Science.gov (United States)

    Kharadi, G. J.

    2013-06-01

    New Fe(III) complexes have been synthesized by the reactions of ferric nitrate with Schiff base derived from 3-substituted phenyl-4-amino-5-hydrazino-1,2,4-triazole and indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non-electrolytes. Elemental analyses suggest that the complexes have 1:1 stoichiometry of the type [FeLn(H2O)(OH)]·xH2O. Structural and spectroscopic properties have been studied on the basis of elemental analyses, infrared spectra, 1H and 13H NMR spectra, electronic spectra, magnetic measurements and FAB mass spectra. FT-IR, 1H and 13H NMR studies reveal that the ligand (Ln) exists in the tautomeric enol form in both the states with intramolecular hydrogen bonding. Magnetic moment and reflectance spectral studies reveal that an octahedral geometry has been assigned to all the prepared complexes. FRAP values indicate that all the compounds have a ferric reducing antioxidant power. The compounds 2 and 3 showed relatively high antioxidant activity while compound 1 and 4 shows poor antioxidant power. Also good antimicrobial activities of the complexes against Staphylococcus aureus, Bacillus subtilis, Serratia marcescens, Pseudomonas aeruginosa and Escherichia coli have been found compared to its free ligands.

  8. APACHE III outcome prediction in patients admitted to the intensive care unit after liver transplantation: a retrospective cohort study.

    Science.gov (United States)

    Keegan, Mark T; Gali, Bhargavi; Findlay, James Y; Heimbach, Julie K; Plevak, David J; Afessa, Bekele

    2009-07-29

    The Acute Physiology and Chronic Health Evaluation (APACHE) III prognostic system has not been previously validated in patients admitted to the intensive care unit (ICU) after orthotopic liver transplantation (OLT). We hypothesized that APACHE III would perform satisfactorily in patients after OLT METHODS: A retrospective cohort study was performed. Patients admitted to the ICU after OLT between July 1996 and May 2008 were identified. Data were abstracted from the institutional APACHE III and liver transplantation databases and individual patient medical records. Standardized mortality ratios (with 95% confidence intervals) were calculated by dividing the observed mortality rates by the rates predicted by APACHE III. The area under the receiver operating characteristic curve (AUC) and the Hosmer-Lemeshow C statistic were used to assess, respectively, discrimination and calibration of APACHE III. APACHE III data were available for 918 admissions after OLT. Mean (standard deviation [SD]) APACHE III (APIII) and Acute Physiology (APS) scores on the day of transplant were 60.5 (25.8) and 50.8 (23.6), respectively. Mean (SD) predicted ICU and hospital mortality rates were 7.3% (15.4) and 10.6% (18.9), respectively. The observed ICU and hospital mortality rates were 1.1% and 3.4%, respectively. The standardized ICU and hospital mortality ratios with their 95% C.I. were 0.15 (0.07 to 0.27) and 0.32 (0.22 to 0.45), respectively. There were statistically significant differences in APS, APIII, predicted ICU and predicted hospital mortality between survivors and non-survivors. In predicting mortality, the AUC of APACHE III prediction of hospital death was 0.65 (95% CI, 0.62 to 0.68). The Hosmer-Lemeshow C statistic was 5.288 with a p value of 0.871 (10 degrees of freedom). APACHE III discriminates poorly between survivors and non-survivors of patients admitted to the ICU after OLT. Though APACHE III has been shown to be valid in heterogenous populations and in certain groups

  9. Complexes of 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III)

    OpenAIRE

    Ferenc, W.; Bernat, M.; Sarzyński, J.; Głuchowska, H.

    2010-01-01

    The complexes of 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III) have been synthesized as polycrystalline hydrated solids, and characterized by elemental analysis, spectroscopy, magnetic studies and also by X-ray diffraction and thermogravimetric measurements. The analysed complexes have the following colours: violet for Nd(III), white for Gd(III) and cream for Ho(III) compounds. The carboxylate groups bind as bidentate chelating (Ho) or bridging ligands (Nd, Gd). On heating to 1173K ...

  10. In Situ Studies on Phase Transitions of Tris(acetylacetonato)-Aluminum(III) Al(acac)3

    National Research Council Canada - National Science Library

    Pienack, Nicole; Ruiz Arana, Laura; Bensch, Wolfgang; Terraschke, Huayna

    2016-01-01

    ...) and luminescence analysis are possible, also monitoring several other reaction parameters. Here, the crystallization of the model system tris(acetylacetonato)-aluminum(III) Al(acac)3 was investigated...

  11. Comparison of geochemical data obtained using four brine sampling methods at the SECARB Phase III Anthropogenic Test CO2 injection site, Citronelle Oil Field, Alabama

    Science.gov (United States)

    Conaway, Christopher; Thordsen, James J.; Manning, Michael A.; Cook, Paul J.; Trautz, Robert C.; Thomas, Burt; Kharaka, Yousif K.

    2016-01-01

    The chemical composition of formation water and associated gases from the lower Cretaceous Paluxy Formation was determined using four different sampling methods at a characterization well in the Citronelle Oil Field, Alabama, as part of the Southeast Regional Carbon Sequestration Partnership (SECARB) Phase III Anthropogenic Test, which is an integrated carbon capture and storage project. In this study, formation water and gas samples were obtained from well D-9-8 #2 at Citronelle using gas lift, electric submersible pump, U-tube, and a downhole vacuum sampler (VS) and subjected to both field and laboratory analyses. Field chemical analyses included electrical conductivity, dissolved sulfide concentration, alkalinity, and pH; laboratory analyses included major, minor and trace elements, dissolved carbon, volatile fatty acids, free and dissolved gas species. The formation water obtained from this well is a Na–Ca–Cl-type brine with a salinity of about 200,000 mg/L total dissolved solids. Differences were evident between sampling methodologies, particularly in pH, Fe and alkalinity. There was little gas in samples, and gas composition results were strongly influenced by sampling methods. The results of the comparison demonstrate the difficulty and importance of preserving volatile analytes in samples, with the VS and U-tube system performing most favorably in this aspect.

  12. "Testing during Study Insulates against the Buildup of Proactive Interference": Correction

    Science.gov (United States)

    Szpunar, Karl K.; McDermott, Kathleen B.; Roedigger, Henry L., III

    2009-01-01

    Reports an error in "Testing during study insulates against the buildup of proactive interference" by Karl K. Szpunar, Kathleen B. McDermott and Henry L. Roediger III ("Journal of Experimental Psychology: Learning, Memory, and Cognition," 2008[Nov], Vol 34[6], 1392-1399). Incorrect figures were printed due to an error in the…

  13. Epidemiological Study of Hospital-Acquired Bacterial Conjunctivitis in a Level III Neonatal Unit

    Directory of Open Access Journals (Sweden)

    Catarina Dias

    2013-01-01

    Full Text Available Background. Conjunctivitis is one of the most frequently occurring hospital-acquired infections among neonates, although it is less studied than potentially life-threatening infections, such as sepsis and pneumonia. Objectives. The aims of our work were to identify epidemiologic characteristics, pathogens, and susceptibility patterns of bacterial hospital-acquired conjunctivitis (HAC in a level III neonatal unit. Materials and Methods. Data were collected retrospectively from patient charts and laboratory databases. Hospital-acquired conjunctivitis was defined in accordance with the Centers for Disease Control/National Healthcare Safety Network (CDC/NHSN diagnostic criteria. Results. One or more episodes of HAC were diagnosed in 4,0% ( of 1492 neonates admitted during the study period. Most of the episodes involved premature (75,4% and low birth weight (75,4% neonates. Infection rates were higher among patients undergoing noninvasive mechanical ventilation (46,7%, parenteral nutrition (13,6%, and phototherapy (6,8%. Predominant pathogens included Serratia marcescens (27,9%, Escherichia coli (23%, and Pseudomonas aeruginosa (18%. Susceptibility patterns revealed bacterial resistances to several antibiotic classes. Gentamicin remains the adequate choice for empirical treatment of HAC in our NICU. Conclusion. It is important to know the local patterns of the disease in order to adjust prevention strategies. Our work contributes to the epidemiological characterization of a sometimes overlooked disease.

  14. Epidemiological Study of Hospital-Acquired Bacterial Conjunctivitis in a Level III Neonatal Unit

    Science.gov (United States)

    Dias, Catarina; Gonçalves, Márcia; João, Anabela

    2013-01-01

    Background. Conjunctivitis is one of the most frequently occurring hospital-acquired infections among neonates, although it is less studied than potentially life-threatening infections, such as sepsis and pneumonia. Objectives. The aims of our work were to identify epidemiologic characteristics, pathogens, and susceptibility patterns of bacterial hospital-acquired conjunctivitis (HAC) in a level III neonatal unit. Materials and Methods. Data were collected retrospectively from patient charts and laboratory databases. Hospital-acquired conjunctivitis was defined in accordance with the Centers for Disease Control/National Healthcare Safety Network (CDC/NHSN) diagnostic criteria. Results. One or more episodes of HAC were diagnosed in 4,0% (n = 60) of 1492 neonates admitted during the study period. Most of the episodes involved premature (75,4%) and low birth weight (75,4%) neonates. Infection rates were higher among patients undergoing noninvasive mechanical ventilation (46,7%), parenteral nutrition (13,6%), and phototherapy (6,8%). Predominant pathogens included Serratia marcescens (27,9%), Escherichia coli (23%), and Pseudomonas aeruginosa (18%). Susceptibility patterns revealed bacterial resistances to several antibiotic classes. Gentamicin remains the adequate choice for empirical treatment of HAC in our NICU. Conclusion. It is important to know the local patterns of the disease in order to adjust prevention strategies. Our work contributes to the epidemiological characterization of a sometimes overlooked disease. PMID:23766676

  15. Americium(iii) and europium(iii) complex formation with lactate at elevated temperatures studied by spectroscopy and quantum chemical calculations.

    Science.gov (United States)

    Barkleit, Astrid; Kretzschmar, Jerome; Tsushima, Satoru; Acker, Margret

    2014-08-07

    Thermodynamic parameters for the complex formation of Am(iii) and Eu(iii) with lactate were determined with UV-vis and time-resolved laser-induced fluorescence spectroscopy (TRLFS) in a temperature range between 25 and 70 °C. The reaction enthalpy decreased with increasing ionic strength. ATR FT-IR and NMR spectroscopy in combination with density functional theory (DFT) calculations revealed structural details of the Eu(iii) lactate 1 : 1 complex: a chelating coordination mode of the lactate with a monodentate binding carboxylate group and the hydroxyl group being deprotonated.

  16. Obesity, albuminuria, and urinalysis findings in US young adults from the Add Health Wave III study.

    Science.gov (United States)

    Ferris, Maria; Hogan, Susan L; Chin, Hyunsook; Shoham, David A; Gipson, Debbie S; Gibson, Keisha; Yilmaz, Sema; Falk, Ronald J; Jennette, J Charles

    2007-11-01

    Obesity has been associated with kidney disease in adults. This study was designed to evaluate the association of obesity with an early marker of kidney disease, albuminuria, among young adults. Urinalysis (n = 9371), albumin-to-creatinine ratio (n = 4463), and body mass index (kg/m2) were measured in the Add Health Wave III cohort (2001 to 2002), a multiethnic sample of young adults followed for approximately 6 yr. Multivariate logistic regression modeled the association of sex-specific albuminuria with body mass index, adjusted for sample weights, sex, race, ethnicity, and glycosuria. Urinalysis revealed that 0.8% had proteinuria, 4.6% had hematuria, 0.2% had combined hematuria and proteinuria, and 1.5% had glycosuria. Albuminuria prevalence was 4.4%. Mean body mass index was higher among those with albuminuria compared with those without. There were no associations between body mass index categories of 25 to or = 35 kg/m2) was associated with albuminuria, compared with the lowest category (OR = 1.76, 95% CI: 1.02 to 3.04). Glycosuria (OR = 4.0; 95% CI: 1.5 to 11.1, p adults is particularly concerning. Obesity may be a target for primary prevention of kidney and cardiovascular disease.

  17. Reaction Time and Mortality from the Major Causes of Death: The NHANES-III Study

    Science.gov (United States)

    Hagger-Johnson, Gareth; Deary, Ian J.; Davies, Carolyn A.; Weiss, Alexander; Batty, G. David

    2014-01-01

    Objective Studies examining the relation of information processing speed, as measured by reaction time, with mortality are scarce. We explored these associations in a representative sample of the US population. Methods Participants were 5,134 adults (2,342 men) aged 20–59 years from the Third National Health and Nutrition Examination Survey (NHANES III, 1988–94). Results Adjusted for age, sex, and ethnic minority status, a 1 SD slower reaction time was associated with a raised risk of mortality from all-causes (HR = 1.25, 95% CI 1.12, 1.39) and cardiovascular disease (CVD) (HR = 1.36, 95% CI 1.17, 1.58). Having 1 SD more variable reaction time was also associated with greater risk of all-cause (HR = 1.36, 95% CI 1.19, 1.55) and CVD (HR = 1.50, 95% CI 1.33, 1.70) mortality. No associations were observed for cancer mortality. The magnitude of the relationships was comparable in size to established risk factors in this dataset, such as smoking. Interpretation Alongside better-established risk factors, reaction time is associated with increased risk of premature death and cardiovascular disease. It is a candidate risk factor for all-cause and cause-specific mortality. PMID:24489645

  18. Synthesis, spectroscopic, DFT and in vitro biological studies of vanadium(III) complexes of aryldithiocarbonates

    Science.gov (United States)

    Andotra, Savit; Kumar, Sandeep; Kour, Mandeep; Vikas; Chayawan; Sharma, Vishal; Jaglan, Sundeep; Pandey, Sushil. K.

    2017-06-01

    Vanadium(III) tris(dithiocarbonates), [(ROCS2)3V] (R = o-, m-, p-CH3C6H4 and 4-Cl-3-CH3C6H3) and donor stabilized addition complexes [(ROCS2)2V(Cl)·L] [L = NC5H5 or P(C6H5)3] were synthesized and characterized by elemental analyses, IR, mass, TGA/DTA, SEM magnetic susceptibility and heteronuclear NMR (1H, 13C and 31P) spectroscopic studies. The cytotoxicity of the complexes was measured in vitro using the cultivated human cell lines. In addition, the antioxidant activities of the ligands and its vanadium complexes were also investigated through their scavenging effect on DPPH radicals. The antimicrobial activity of ligands and some complexes has been conducted against three bacterial strains and fungus. The density functional theory (DFT) calculations of ligands and vanadium complexes were performed by the DFT/B3LYP/LANL2DZ method to obtain the optimized molecular geometry, vibrational frequencies, the highest occupied molecular orbital (HOMO), the lowest unoccupied molecular orbital (LUMO), thermodynamic properties and various other quantum-mechanical parameters.

  19. Implications from the Air Force/Texas Coronary Atherosclerosis Prevention Study for the Adult Treatment Panel III guidelines.

    Science.gov (United States)

    Clearfield, Michael; Downs, John R; Lee, Michael; Langendorfer, Alex; McConathy, Walter; Gotto, Antonio M

    2005-12-15

    The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) first reported its results in 1998, before the 2001 publication of the National Cholesterol Education Program-Adult Treatment Panel III guidelines (NCEP-ATP III) and 2004 update. Our objective was to investigate the impact of these guidelines on the AFCAPS/TexCAPS cohort. The main outcome measures were the event rates of first acute major coronary events (AMCEs), which were reduced 39% by lovastatin (95% confidence interval [CI] 21% to 53%, p treatment with a medication is now considered optional. In conclusion, the ability of the ATP III guidelines and its update has markedly improved our ability to define coronary heart disease risk; however, other components of the guidelines, such as non-high-density lipoprotein cholesterol and the optional low-density lipoprotein cholesterol target goal of <100 mg/dl, still require additional evaluation.

  20. GALEN skin test study III: Minimum battery of test inhalent allergens needed in epidemiological studies in patients

    DEFF Research Database (Denmark)

    Bousquet, P-J; Burbach, G; Heinzerling, L M

    2009-01-01

    the allergens selection. Result: Among the 3034 patients involved, 1996 (68.2%) were sensitized to at least one allergen. Overall, eight allergens (grass pollen, Dermatophagoides pteronyssinus, birch pollen, cat dander, Artemisia, olive pollen, Blatella and Alternaria) allowed to identified more than 95...... or Alternaria]). According to country, up to 13 allergens were needed to identify all sensitized subjects. Conclusion: Eight to ten allergens allowed the identification of the majority of sensitized subjects. For clinical care of individual patients, the whole battery of 18 allergens is needed to appropriately...

  1. A new supramolecular chromium(III) complex: Synthesis, structural determination, optical study, magnetic and antibacterial activity

    Science.gov (United States)

    Dridi, Rihab; Dhieb, Cyrine; Cherni, Saoussen Namouchi; Boudjada, Nassira Chniba; Sadfi Zouaoui, Najla; Zid, Mohamed Faouzi

    2018-01-01

    A new chromium (III) complex 1,5-Naphthyridine Trans-diaquadioxalatochromate (III) dihydrate, had been synthesized by self-assembly of chromium (III) nitrate with oxalic acid and 1,5-Naphthyridine. The complex was characterized by X-ray diffraction, Fourier Transform Infrared spectroscopy, thermogravimetric analysis and UV-Visible spectroscopy. The crystal morphology was carried out using Bravais-Friedel-Donnay-Harker (BFDH) model. Single crystal X-Ray structure determination revealed that the complex posses two crystallographically independent Cr(III) centers. Each Cr(III) has a distorted octahedron geometry involving two axial O atoms from two water molecules and four equatorial O atoms from two oxalate dianions forming trans-[Cr(C2O4)2(H2O)2]- complex anions. The charge compensation is accomplished by the incorporation of 1,5-Naphthyridine cations. Connection between these entities is ensured by means of strong hydrogen bonds giving rise to 3D supramolecular architecture. Hirshfeld surface analysis and the related 2D fingerprint plots were used for decoding plausible intermolecular interactions in the crystal packing. The magnetic properties of the complex had been investigated and discussed in the context of its structure. The antimicrobial activity was evaluated by disc diffusion method highlighting an antagonistic effect of the synthesized complex against Gram-positive and Gram-negative species.

  2. Perceived stress, common carotid intima media thickness and occupational status: The Paris Prospective Study III.

    Science.gov (United States)

    Wiernik, Emmanuel; Lemogne, Cédric; Thomas, Frédérique; Perier, Marie-Cécile; Guibout, Catherine; Nabi, Hermann; Laurent, Stéphane; Pannier, Bruno; Boutouyrie, Pierre; Jouven, Xavier; Empana, Jean-Philippe

    2016-10-15

    The association between psychological factors and cardiovascular diseases may depend upon socio-economic status. The present cross-sectional study examined the potential moderating role of occupational status on the association between perceived stress and intima-media thickness (IMT), using baseline examination data of the Paris Prospective Study III. IMT was measured in the right common carotid artery (CCA-IMT) 1cm below the bifurcation, in a zone free of discrete plaques, using non-invasive high-resolution echotracking. Perceived stress was measured with the 4-item Perceived Stress Scale. The association between perceived stress and CCA-IMT was explored using linear regression analysis and regression coefficients (b) were given per 1-point increment. The study population included 5140 participants (3539 men) in the labor force aged 55.9years on average (standard deviation: 3.9), and who were free of personal history of cardiovascular disease and not on psychotropic drugs. There was a non-significant trend between perceived stress and CCA-IMT after adjustment for socio-demographic, self-rated health and cardiovascular risk factors (b [95% CI] 1.02 [-0.08;2.12]; p=0.069). However, multivariable stratified analysis indicates a significant and robust association between perceived stress and CCA-IMT in unemployed participants (b [95% CI] 3.30 [0.44;6.17]), and an association of same magnitude in working participants with low occupational status but without reaching statistical significance. The association between perceived stress and CCA-IMT may depend upon employment status. These results may explain why psychological stress is more tightly linked to cardiovascular disease among individuals facing social adversity. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  3. The sky is falling III: The effect of deposition from static solid rocket motor tests on juvenile crops.

    Science.gov (United States)

    Doucette, William J; Curry, Eric; McNeill, Laurie S; Heavilin, Justin

    2017-12-01

    A mixture of combustion products (mainly hydrogen chloride, aluminum oxide, and water) and entrained soil, referred to as Test Fire Soil (TFS), can be deposited on crops during static solid rocket motor tests. The impact of a reported worst-case event was previously evaluated by exposing corn and alfalfa to 3200-gTFS/m(2) at 54days after emergence. Exposures via soil and leaves were evaluated separately. Reduced growth (soil exposure) and leaf "scorch" (leaf exposure) were attributed mainly to the high chloride concentrations in the TFS (56,000mg/kg). A follow-up study was conducted to evaluate the effect of a typical deposition event (70-gTFS/m(2), estimated by radar during several tests) and exposure (soil and leaves simultaneously) on juvenile corn, alfalfa, and winter wheat. Younger crops were used to examine potential age sensitivity differences. Impact was evaluated by comparing the growth, elemental composition, and leaf chlorophyll content of treated and untreated plants. The relationship between deposition exposure and response was also addressed. Growth of corn, alfalfa, and winter wheat exposed to a typical TFS loading was not impacted, although slightly elevated concentrations of aluminum and iron were found in the leaves. At the highest loadings used for the exposure-response experiment, concentrations of chloride and calcium were higher in TFS-exposed corn leaves than in the untreated leaves. Overall results indicate that exposure to a typical deposition event does not adversely impact juvenile crops and that younger plants may be less vulnerable to TFS. However, higher TFS loadings can cause leaf scorch and increase the leaf concentrations of some elements. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Diagnosis and immunotherapy of mould allergy. III. Diagnosis of Cladosporium allergy by means of symptom score, bronchial provocation test, skin prick test, RAST, CRIE and histamine release.

    Science.gov (United States)

    Malling, H J; Dreborg, S; Weeke, B

    1986-01-01

    Thirty-three adult asthmatic patients suspected of mould allergy were investigated by in vivo and in vitro tests in order to establish a specific diagnosis of asthma caused by the mould species Cladosporium. The patients were evaluated by daily symptom scores in the peak Cladosporium season, bronchial provocation test (BPT), skin prick test (SPT), RAST, histamine release from basophil granulocytes (HIST), and crossed radioimmunoelectrophoresis (CRIE), and the results were scored as negative (score 0), equivocal (score 1) or positive (score 2). Based on daily symptom scores and the result of BPT the patients were classified as being manifest allergic (asthma) to Cladosporium (positive allergy), inconclusive or negative. Positive allergy was defined as asthma symptoms oscillating with the spore concentration and a BPT score 2 (positive at allergen concentration less than 10,000 BU). Negative allergy was defined as no asthma symptoms and a negative BPT (score 0) and inconclusive in the case of symptoms and BPT sum of score 1-3. According to the classification a final diagnosis (positive or negative) could be established in 85% of the patients. "False positive" tests were found: for BPT in 27%, SPT 18%, RAST 0%, HIST 18%, and CRIE 0%. The corresponding figures for "false negative" were: BPT 0%, SPT 0%, RAST 27%, HIST 18%, and CRIE 23%. The relative risk of being allergic in spite of a negative test result was 0% for BPT and SPT, and 25-30% with RAST, HIST, and CRIE. In the case of positive test the risk was 90-100%. Excluding BPT, SPT was found to be the optimal single test to predict/rule out clinical allergy. A stepwise combination of positive SPT and positive RAST was found exclusively in patients clinically evaluated as positive, and does not call for an additional BPT. Using a potent allergenic extract a negative SPT excluded clinically important allergy. The primary conclusion of the study, however, is that the final diagnosis of Cladosporium asthma could not be

  5. Probing the Natural World, Level III, Teacher's Edition: Why You're You. Intermediate Science Curriculum Study.

    Science.gov (United States)

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). The chapters include basic information about heredity, activities, and optional "excursions." The answers to all activities are included. An introduction describes the work of Gregor Mendel and his…

  6. Studying the evolution of a type III radio from the Sun up to 1 AU

    Science.gov (United States)

    Mann, Gottfried; Breitling, Frank; Vocks, Christian; Fallows, Richard; Melnik, Valentin; Konovalenko, Alexander

    2017-04-01

    On March 16, 2016, a type III burst was observed with the ground-based radio telescopes LOFAR and URAN-2 as well as with the radiospectrometer aboard the spacecraft WIND.It started at 80 MHz at 06:37 UT and reached 50 kHz after 23 minutes. A type III burst are considered as the radio signature of an electron beam travelling from the corona into the interplanetary space. The energetic electrons carrying the beam excites Langmuir waves, which convert into radio waves by wave-particle interaction. The relationship between the drift rate and the frequency as derived from the dynamic radio spectra reveals that the velocity of the electrons generating the radio waves of the type III burst is increasing with increasing distance from the center of the Sun.

  7. Study of the selectivity of poly-nitrogenous extracting molecules in the complexation of actinides (III) and lanthanides (III) in solution in anhydrous pyridine; Etude de la selectivite de molecules extractantes polyazotees dans la complexation des actinides (III) et des lanthanides (III) en solution dans la pyridine anhydre

    Energy Technology Data Exchange (ETDEWEB)

    Riviere, Ch

    2000-10-05

    The aim of this work is to better understand the factors which contribute to the separation of lanthanides(III) and actinides(III). Polydentate nitrogenous molecules present an interesting selectivity. A thermodynamic study of the complexation in pyridine of lanthanide and uranium by the bipyridine ligand (bipy) has been carried out. The formation constants and the thermodynamic values of the different complexes have been determined. It has been shown that the bipy complexes formation is controlled by the enthalpy and unfavored by the entropy. The conductometry has revealed too a significant difference in the uranium and lanthanides complexation by the bipyridine ligand. The use of the phenanthroline ligand induces a better complexation of the metallic ions but the selectivity is not improved. On the other hand, the decrease of the basicity and the increase of the ligand denticity (for instance in the case of the use of ter-pyridine) favour the selectivity without improving the complexation. The selectivity difference for the complexation of actinides(III) and lanthanides(III) by the different studied ligands (independent systems) has been confirmed by experiments of inter-metals competition. (O.M.)

  8. Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX).

    Science.gov (United States)

    Vincent, Jean-Louis; Privalle, Christopher T; Singer, Mervyn; Lorente, José A; Boehm, Erwin; Meier-Hellmann, Andreas; Darius, Harald; Ferrer, Ricard; Sirvent, Josep-Maria; Marx, Gernot; DeAngelo, Joseph

    2015-01-01

    To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene, against placebo in patients with vasopressor-dependent distributive shock. Multicenter, randomized, placebo-controlled, open-label study. Sixty-one participating ICUs in six European countries (Austria, Belgium, Germany, the Netherlands, Spain, and United Kingdom). All patients admitted with distributive shock, defined as the presence of at least two systemic inflammatory response syndrome criteria, persisting norepinephrine dependence and evidence of organ dysfunction/hypoperfusion despite adequate fluid resuscitation. Patients were randomized to receive 0.25 mL/kg/hr pyridoxalated hemoglobin polyoxyethylene (20 mg Hb/kg/hr) or an equal volume of placebo, infused for up to 150 hours, in addition to conventional vasopressor therapy. The study was stopped after interim analysis showed higher mortality in the pyridoxalated hemoglobin polyoxyethylene group and an increased prevalence of adverse events. At this time, 377 patients had been randomized to pyridoxalated hemoglobin polyoxyethylene (n = 183) or placebo (n = 194). Age, gender, type of patient (medical/surgical), and Acute Physiology and Chronic Health Evaluation II scores were similar between groups. Twenty-eight-day mortality rate was 44.3% in the pyridoxalated hemoglobin polyoxyethylene group versus 37.6% in the placebo group (OR, 1.29; 95% CI, 0.85-1.95; p = 0.227). In patients with higher organ dysfunction scores (Sepsis-related Organ Failure Assessment > 13), mortality rates were significantly higher in the pyridoxalated hemoglobin polyoxyethylene group when compared with those in placebo-treated patients (60.9% vs 39.2%; p = 0.014). Survivors who received pyridoxalated hemoglobin polyoxyethylene had a longer vasopressor-free time (21.3 vs 19.7 d; p = 0.035). In this randomized, controlled phase III trial in patients with vasopressor-dependent distributive shock

  9. Qualification of TRACE V5.0 Code against Fast Cooldown Transient in the PKL-III Integral Test Facility

    Directory of Open Access Journals (Sweden)

    Eugenio Coscarelli

    2013-01-01

    Full Text Available The present paper deals with the analytical study of the PKL experiment G3.1 performed using the TRACE code (version 5.0 patch1. The test G3.1 simulates a fast cooldown transient, namely, a main steam line break. This leads to a strong asymmetry caused by an increase of the heat transfer from the primary to the secondary side that induces a fast cooldown transient on the primary side-affected loop. The asymmetric overcooling effect requires an assessment of the reactor pressure vessel integrity considering PTS (pressurized thermal shock and an assessment of potential recriticality following entrainment of colder water into the core area. The aim of this work is the qualification of the heat transfer capabilities of the TRACE code from primary to secondary side in the intact and affected steam generators (SGs during the rapid depressurization and the boiloff in the affected SG against experimental data.

  10. Removal of arsenic(III) from water by magnetic binary oxide particles (MBOP): Experimental studies on fixed bed column.

    Science.gov (United States)

    Dhoble, Rajesh M; Maddigapu, Pratap Reddy; Rayalu, Sadhana S; Bhole, A G; Dhoble, Ashwinkumar S; Dhoble, Shubham R

    2017-01-15

    Magnetic binary oxide particles (MBOP) were prepared by template method using chitosan in the laboratory for the removal of As(III) from water. The prepared MBOP has super paramagnetic property which is sufficient for magnetic separation. Column study was performed at two different flow rates of 2.0ml/min and 5.0ml/min and comparison was made with regenerated MBOP, commercial activated carbon and commercial activated alumina. It is observed that fresh MBOP has higher breakthrough time and capacity than regenerated MBOP by a factor of 1.25 and 1.37 respectively. In Logit method, the values of K (adsorption rate constant) and N (adsorption capacity coefficient) were obtained as 0.2066 (L/mgh) and 1014(mg/L) for 5.0ml/min flow rate. All the drinking water parameters are within the limit of BIS 10500-2012. Toxicity characteristic leaching procedure (TCLP) and semi dynamic tests were performed for the mix ratios of 01:02:01, 01:02:05 and 01:02:10 and were found safe for the disposal. Copyright © 2016. Published by Elsevier B.V.

  11. Study of the involved sorption mechanisms of Cr(VI) and Cr(III) species onto dried Salvinia auriculata biomass.

    Science.gov (United States)

    Módenes, Aparecido Nivaldo; de Oliveira, Ana Paula; Espinoza-Quiñones, Fernando R; Trigueros, Daniela Estelita Goes; Kroumov, Alexander Dimitrov; Bergamasco, Rosângela

    2017-04-01

    Removal of Cr(VI) species by dried biomass of the aquatic macrophyte Salvinia auriculata was studied in order to understand the involved sorption mechanisms. Kinetic tests were carried out under the conditions such as concentration range of Cr(VI) from 50 to 250 mg L-1 and a temperature of 30 °C. Modification of the biosorbent by the presence of Cr(VI) species was assessed by analysis of its porosity, density and infrared molecular absorption spectrum. A series of experimental approaches involving directed chemical modifications on the biosorbent surface was performed. The main functional groups involved in the sorption mechanisms were identified. The gas sorption analyser was applied and proved that a strong chemical effect of Cr(VI) species on the surface took place, resulting in a leaching organic matter with an obvious and significant increase in the porosity parameters. The intra-particle diffusion model revealed different mass transfer zones into the adsorbent during Cr(VI) removal. New combined Langmuir and Dubinin-Radushkevich isotherm was the best to fit the equilibrium data of Cr(VI) species removal. Finally, Cr(VI) removal was mainly mediated by a redox process where Cr(III) species were formed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. The effect of laparoscopic surgery in stage II and III right-sided colon cancer: a retrospective study

    Directory of Open Access Journals (Sweden)

    Kye Bong-Hyeon

    2012-05-01

    Full Text Available Abstract Background This retrospective study compared the clinicopathological results among three groups divided by time sequence to evaluate the impact of introducing laparoscopic surgery on long-term oncological outcomes for right-sided colon cancer. Methods From April 1986 to December 2006, 200 patients who underwent elective surgery with stage II and III right-sided colon cancer were analyzed. The period for group I referred back to the time when laparoscopic approach had not yet been introduced. The period for group II was designated as the time when first laparoscopic approach for right colectomy was carried out until we overcame its learning curve. The period for group III was the period after overcoming this learning curve. Results When groups I and II, and groups II and III were compared, overall survival (OS did not differ significantly whereas disease-free survival (DFS in groups I and III were statistically higher than in group II (P = 0.042 and P = 0.050. In group III, laparoscopic surgery had a tendency to provide better long-term OS ( P = 0.2036 and DFS ( P = 0.2356 than open surgery. Also, the incidence of local recurrence in group III (2.6% was significantly lower than that in groups II (7.4% and I (12.1% ( P = 0.013. Conclusions Institutions should standardize their techniques and then provide fellowship training for newcomers of laparoscopic colon cancer surgery. This technique once mastered will become the gold standard approach to colon surgery as it is both safe and feasible considering the oncological and technical aspects.

  13. Comparative electrochemical study of some cobalt(III and cobalt(II complexes with azamacrocycles and b-diketonato ligands

    Directory of Open Access Journals (Sweden)

    K. BABIC-SAMARDZIJA

    2003-12-01

    Full Text Available The electrochemical properties of eight mixed-ligand cobalt(III and cobalt(II complexes of the general formulas [CoIII(Raccyclam](ClO42 (1–(4 and [Co2II(Ractpmc](ClO43 (5–(8 were studied. The substances were investigated in aqueous NaClO4 solution and non-aqueous LiClO4/CH3CN solution by cyclic voltammetry at a glassy carbon electrode. In aqueous solution, cyclam and Rac ligands being soluble in water undergo anodic oxidation. Coordination to Co(III in complexes 1–4, stabilizes these ligands but reversible peaks in catohodic region indicate the redox reaction CoIII/CoII ion. In the case of the binuclear Co(II complexes 5–8, peaks recorded on the CVs represent oxidation of the bridged Rac ligand. The complexes examined influence the cathodic reaction of hydrogen evolution in aqueous solutions by shifting its potential to more negative values and its current is increased. In non-aqueous solution the CVs of the ligands show irreversible anodic peaks for cyclam, tpmc and for the Rac ligands soluble in acetonitrile. The absence of any peaks in the case of the investigated complexes 1–4 indicates that coordination to Co(III stabilizes both the cyclam and Rac ligands. Cyclic voltammograms of the complexes 5–8 show oxidation processes of the Rac ligand and Co(II ions but the absence of a highly anodic peak of the coordinated macrocycle tpmc shows its stabilization. Contrary to in aqueous solution, the redox reaction Co(III/Co(II does not occur in acetonitrate indicating a higher stability of the complexes 1–4 in this media in comparison with the binuclear cobalt(II-tpmc complexes 5–8.

  14. HLA-D gene studies in relation to immune responsiveness to a grass allergen Lol p III.

    Science.gov (United States)

    Ansari, A A; Shinomiya, N; Zwollo, P; Marsh, D G

    1991-01-01

    The grass pollen allergen Lol p III (Mr 11,000) is a well-characterized antigen that has been found useful in immunogenetic studies of human immune responsiveness. Since immune responsiveness to this allergen is associated with HLA-DR3, we investigated whether there was any sequence in the HLA-D region that would render a person "susceptible" [antibody (Ab)-positive] to the allergen. By sequence-specific oligonucleotide (SSO) slot-blot and sequence analyses of polymerase chain reaction (PCR)-amplified genomic DNA from Lol p III responder and nonresponder subjects, Ab responsiveness was found to be strongly associated with the sequence Glu-Tyr-Ser-Thr-Ser (EYSTS), present in the first polymorphic regions of DR beta I polypeptide chains of DR3, DR11 (split of DR5), and DRw6. Of the 41 grass-allergic subjects investigated, 19 had the EYSTS sequence, of whom 18 (95%) were Lol p III immunoglobulin G (IgG) Ab responders; among the 22 EYSTS- subjects, ten were Lol p III responders (P = 0.001, relative risk = 21.6). No such association was found with any polymorphic sequences in other DR beta chains, or in DQ alpha I and DQ beta I chains. These findings suggest that the EYSTS sequence is important in the presentation of an epitope of Lol p III; other sequence(s) may be involved in the presentation of other epitope(s). To our knowledge, this is the first demonstration of a strong association between a specific HLA sequence and immune responsiveness to a well-defined antigen. The paper shows that presence of the EYSTS sequence classifies subjects as Lol p III responders in 18/19 cases.

  15. STUDI ENDEMISITAS FILARIASIS DI WILAYAH KECAMATAN PEMAYUNG, KABUPATEN BATANGHARI PASCA PENGOBATAN MASSAL TAHAP III

    Directory of Open Access Journals (Sweden)

    Yahya Yahya

    2013-05-01

    Full Text Available Abstract Filariasis endemicity research in District Pemayung, Batanghari Regency Post-Mass Drug Administration Phase III has been implemented. The study aims to determine the prevalence of filariasis, microfilaria worm species, the periodicity, reservoir determination and evaluate the results of mass treatment activities that have been 3 times. The number of people who checked their blood preparation for the examination as many as 538. Blood sampling for the periodicity of the parasite examinations performed on 4 persons, each carried out blood sampling every 2 hours for 24 hours. People microfilariae with microfilariae positive number as many as 8 people to rate microfilariae (Mf rate 1.5%.. The highest parasite density of 17.493 per 20 cu mm of blood occurred at 1:00 am and decresing to 0,415 per 20 cu mm of blood at 07.00 am. The parasite was found in sub periodic nokturna 3 subjects and 1 subject was found only be found in the morning and afternoon. The results of examination of 12 cats and two monkeys were found two positive cats with Brugia malayi microfilariae. Cats that were examined and the positive was one house cat and one stray cat. The conclusion from this study showed that filariasis was still endemic with periodicity of microfilariae was sub periodic nokturna and was zoonotic. Recommendations of this study was that mass treatment  was done by giving the drug directly and took medicine in front of the officers, examination and treatment of microfilariae positive cats. Key words: microfilariae rate, periodicity, Brugia malayi, reservoir. Abstrak  Submit : 28-03-2012  Review : 04-04-2012 Review : 11-06-2012 revisi : 29–08-2012Penelitian untuk menentukan tingkat endemisitas filariasis di wilayah Kecamatan Pemayung, Kabupaten Batanghari Pasca Pengobatan Massal Tahap III telah dilaksanakan. Penelitian bertujuan untuk mengetahui prevalensi filariasis, mengetahui spesies cacing mikrofilaria, periodisitas mikrofilaria dan pemeriksaan

  16. Identification and functional study of type III-A CRISPR-Cas systems in clinical isolates of Staphylococcus aureus.

    Science.gov (United States)

    Cao, Linyan; Gao, Chun-Hui; Zhu, Jiade; Zhao, Liping; Wu, Qingfa; Li, Min; Sun, Baolin

    2016-12-01

    The CRISPR-Cas (clustered regularly interspaced short palindromic repeats [CRISPR]-CRISPR associated proteins [Cas]) system can provide prokaryote with immunity against invading mobile genetic elements (MGEs) such as phages and plasmids, which are the main sources of staphylococcal accessory genes. To date, only a few Staphylococcus aureus strains containing CRISPR-Cas systems have been identified, but no functional study in these strains has been reported. In this study, 6 clinical isolates of S. aureus with type III-A CRISPR-Cas systems were identified, and whole-genome sequencing and functional study were conducted subsequently. Genome sequence analysis revealed a close linkage between the CRISPR-Cas system and the staphylococcal cassette chromosome mec (SCCmec) element in five strains. Comparative sequence analysis showed that the type III-A repeats are conserved within staphylococci, despite of the decreased conservation in trailer-end repeats. Highly homologous sequences of some spacers were identified in staphylococcal MGEs, and partially complementary sequences of spacers were mostly found in the coding strand of lytic regions in staphylococcal phages. Transformation experiments showed that S. aureus type III-A CRISPR-Cas system can specifically prevent plasmid transfer in a transcription-dependent manner. Base paring between crRNA and target sequence, the endoribonuclease, and the Csm complex were proved to be necessary for type III-A CRISPR-Cas immunity. Copyright © 2016 Elsevier GmbH. All rights reserved.

  17. Immobilization of Ionophore and Surface Characterization Studies of the Titanium(III Ion in a PVC-Membrane Sensor

    Directory of Open Access Journals (Sweden)

    Majid Rezayi

    2012-06-01

    Full Text Available Novel ionophores comprising various hydroxide and amine structures were immobilized onto poly(vinyl chloride (PVC matrices, and these were examined to determine Ti(III selectivity. To predict the selectivity of Ti(III, a PVC membrane was used to investigate the binding of Ti(III to c-methylcalix[4]resorcinarene (CMCR. The study showed that the chelating ligand, CMCR, was coordinated selectively to Ti(III at eight coordination sites involving the oxygen atoms at the interface of the membrane/solution. The membrane was prepared, based on CMCR as an ionophore, sodium tetrakis(4-fluorophenyl borate (NaTFPB as a lipophilic ionic additive, and dioctylphthalate (DOP as a plasticizer. The immobilization of the ionophore and surface characterization studies revealed that the performance of CMCR-immobilized PVC was equivalent to that of mobile ionophores in supported liquid membranes (SLMs. The strengths of the ion-ionophore (CMCR-Ti(OH(OH252+ interactions and the role of ionophores on membranes were studied via UV-Vis, Fourier transform infrared spectroscopy (FT–IR, scanning electron microscopy (SEM and and X-ray diffraction (XRD.

  18. A novel near monochromatic red emissive europium(III) metal-organic framework based on 1,2,4,5-benzenetetracarboxylate: From synthesis to photoluminescence studies

    Science.gov (United States)

    Lahoud, Marcelo G.; Frem, Regina C. G.; Marques, Lippy F.; Arroyos, Guilherme; Brandão, Paula; Ferreira, Rute A. S.; Carlos, Luís D.

    2017-09-01

    This work presents the synthesis, solid state characterization (infrared spectroscopy, thermal analysis (TGA/DTA), powder and single crystal X-ray diffraction) and photoluminescence studies of a new europium metal-organic framework (MOF), [Eu2(Btec)1,5(H2O)]n (Btec4-=1,2,4,5-benzenetetracarboxylate anion). Single crystal X-ray diffraction analysis reveals that the material has a three-dimensional network, with two crystallographically independent Eu(III) ions adopting different coordination geometries. This structure presents one of the Btec4- anions acting as a μ8-bridging linker, with the carboxylate groups in distinct connection to Eu(III) ions, culminating into an unknown coordination mode for the linker. The results of thermogravimetric analyses indicate that the MOF has high thermal stability, with this characteristic being of great interest for the application of these compounds in several fields such as catalysis and photonics. The luminescent properties showed that the Eu(III) ions are a local-spectroscopic probe, with the compound presenting a red emission when excited in the UV spectral region with absolute emission quantum yield values of 0.48 ± 0.05. The thermal dependence on the intensity of the transitions originating from the 7F1 level, especially the 7F1 → 5D1 transition, was studied. These results opens the possibility to test this MOF [Eu2(Btec)1.5(H2O)]n in the field of molecular thermometry.

  19. Rapid and sensitive lateral flow immunoassay method for determining alpha fetoprotein in serum using europium (III) chelate microparticles-based lateral flow test strips.

    Science.gov (United States)

    Liang, Rong-Liang; Xu, Xu-Ping; Liu, Tian-Cai; Zhou, Jian-Wei; Wang, Xian-Guo; Ren, Zhi-Qi; Hao, Fen; Wu, Ying-Song

    2015-09-03

    Alpha-fetoprotein (AFP), a primary marker for many diseases including various cancers, is important in clinical tumor diagnosis and antenatal screening. Most immunoassays provide high sensitivity and accuracy for determining AFP, but they are expensive, often complex, time-consuming procedures. A simple and rapid point-of-care system that integrates Eu (III) chelate microparticles with lateral flow immunoassay (LFIA) has been developed to determine AFP in serum with an assay time of 15 min. The approach is based on a sandwich immunoassay performed on lateral flow test strips. A fluorescence strip reader was used to measure the fluorescence peak heights of the test line (HT) and the control line (HC); the HT/HC ratio was used for quantitation. The Eu (III) chelate microparticles-based LFIA assay exhibited a wide linear range (1.0-1000 IU mL(-1)) for AFP with a low limit of detection (0.1 IU mL(-1)) based on 5ul of serum. Satisfactory specificity and accuracy were demonstrated and the intra- and inter-assay coefficients of variation (CV) for AFP were both <10%. Furthermore, in the analysis of human serum samples, excellent correlation (n = 284, r = 0.9860, p < 0.0001) was obtained between the proposed method and a commercially available CLIA kit. Results indicated that the Eu (III) chelate microparticles-based LFIA system provided a rapid, sensitive and reliable method for determining AFP in serum, indicating that it would be suitable for development in point-of-care testing. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Electrochemical study of Tm (III) ions on W and oxo acidity reactions in the LiCI-KCI eutectic; Estudio electroquimico de disoluciones de Tm (III) sobre W y reacciones de oxoacidez en el eutectico LiCI.-KCl

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez Requejo, P.

    2010-07-01

    Study of the electrochemical behaviour of Tm (III) dissolutions in the LiCI-KCI eutectic mixture using inert electrodes (W) and reagent electrodes (Al). On W, TM (III) ions are reduced in two consecutives stages sufficiently separated. The TM electro-reduction on Al makes room for the formation of intermetallic compounds so the use of an Ai electrode is appropriate to decontamination operations.

  1. Emission energy of azole-based ionic iridium(III) complexes: a theoretical study.

    Science.gov (United States)

    Pla, Paula; Junquera-Hernández, José M; Bolink, Henk J; Ortí, Enrique

    2015-05-14

    A theoretical density functional theory study has been performed on different families of cationic cyclometallated Ir(III) complexes with the general formula [Ir(C^N)2(N^N)](+) and azole-based ligands. The goal was to investigate the effect that the number and position of the nitrogen atoms of the azole ring have on the electronic structure and emission wavelength of the complex. The increase in the number of nitrogen atoms changes the relative energy of the HOMO and LUMO levels and leads to a gradual shift in the emission wavelength that can be larger than 100 nm. The direction of the shift however depends on the ligand in which the azole ring is introduced. The emission shifts to bluer wavelengths when the azole forms part of the cyclometallating C^N ligands, whereas it shifts to the red when the 5-membered ring is incorporated into the ancillary N^N ligand. The position of the nitrogen atoms in the azole ring also plays an important role in determining the emission energy. Complexes with phenyl-azole C^N ligands bearing a nitrogen in the azole position to which the phenyl is linked show a markedly blue-shifted emission compared to complexes with the same number of nitrogen atoms in the azole ring and bearing a carbon atom in that position. Therefore, when comparing the emission properties of azole-based [Ir(C^N)2(N^N)](+) complexes, not only the number of nitrogen atoms of the azole but also their position in the ring and the ligand where the azole ring is incorporated should be taken into account.

  2. Preparation and electrochemical nanogravimetric study on the ruthenium(III) trichloride-polypyrrole nanocomposite

    Energy Technology Data Exchange (ETDEWEB)

    Inzelt, G. [Department of Physical Chemistry, Eoetvoes Lorand University, Budapest, Pazmany Peter setany 1/A, H-1117 (Hungary)], E-mail: inzeltgy@chem.elte.hu; Roka, A. [Department of Physical Chemistry, Eoetvoes Lorand University, Budapest, Pazmany Peter setany 1/A, H-1117 (Hungary)

    2008-04-20

    Nanocomposites were prepared by in situ redox intercalative polymerization method, in which {alpha}-RuCl{sub 3} microcrystals were soaked in pyrrole. Polypyrrole (PP) was formed as a result of the intercalation of pyrrole into the layered structure of RuCl{sub 3} crystal and the reaction between pyrrole and the host material. The appearance of polypyrrole was proven by infrared spectroscopy. The as-formed (PP){sup z+}(RuCl{sub 3}){sup z-} nanocomposites were attached to paraffin-impregnated graphite or gold surfaces and studied by cyclic voltammetry and electrochemical nanogravimetry. The redox behaviour of the composite shows the electrochemical transformations of both the polypyrrole and RuCl{sub 3}. The redox waves of PP are similar to those observed for very thin PP films. It attests that the response is originated from monolayer-like PP film situated between RuCl{sub 3} layers. The transport of the charge-compensating ions reflects the variation of the oxidation states of both PP and RuCl{sub 3}. The nanocomposites behave as self-doped layers in the potential region when both constituents are charged, i.e., PP is partially oxidized while RuCl{sub 3} is partially reduced, since the electroneutrality is assured by mutual charge compensation. When PP is reduced, cations enter the layer to counterbalance the negative charge resulted from the reduction of Ru(III) to Ru(II). It was also found that the intercalation of water molecules is - albeit still substantial - smaller than that of pure RuCl{sub 3} microcrystals which is related to the presence of PP between the RuCl{sub 3} layers.

  3. Detoxification of Pesticide-Containing Wastewater with FeIII, Activated Carbon and Fenton Reagent and Its Control Using Three Standardized Bacterial Inhibition Tests

    Directory of Open Access Journals (Sweden)

    Eduard Rott

    2017-12-01

    Full Text Available Discharge of toxic industrial wastewaters into biological wastewater treatment plants may result in inhibition of activated sludge bacteria (ASB. In order to find an appropriate method of detoxification, the wastewater of a pesticide-processing plant in Vietnam was treated with three different methods (FeIII, powdered activated carbon (PAC, Fenton (FeII/H2O2 analyzing the detoxification effect with the nitrification inhibition test (NIT, respiration inhibition test (RIT and luminescent bacteria test (LBT. The heterotrophic ASB were much more resistant to the wastewater than the autotrophic nitrificants. The NIT turned out to be more suitable than the RIT since the NIT was less time-consuming and more reliable. In addition, the marine Aliivibrio fischeri were more sensitive than the nitrificants indicating that a lack of inhibition in the very practical and time-efficient LBT correlates with a lack of nitrification inhibition. With 95%, the Fenton method showed the highest efficiency regarding the chemical oxygen demand (COD removal. Although similar COD removal (60–65% was found for both the FeIII and the PAC method, the inhibitory effect of the wastewater was reduced much more strongly with PAC. Both the NIT and the LBT showed that the PAC and Fenton methods led to a similar reduction in the inhibitory effect.

  4. Phase I/II Pilot Study of Mixed Chimerism to Treat Inherited Metabolic Disorders

    Science.gov (United States)

    2017-11-15

    Hurler Syndrome (MPS I); Hurler-Scheie Syndrome; Hunter Syndrome (MPS II); Sanfilippo Syndrome (MPS III); Krabbe Disease (Globoid Leukodystrophy); Metachromatic Leukodystrophy (MLD); Adrenoleukodystrophy (ALD and AMN); Sandhoff Disease; Tay Sachs Disease; Pelizaeus Merzbacher (PMD); Niemann-Pick Disease; Alpha-mannosidosis

  5. Vortices in dam reservoir: A case study of Karun III dam

    Indian Academy of Sciences (India)

    Velocity measurements are performed in the hydraulic model of Karun III ... Formation of vortices at power intakes is a challenging problem for hydraulic engineers. The ..... Eng., 137(6): 701–705. Yildirim N, Eyüpo˘glu A and Tastan K 2012 Critical Submergence for Dual Rectangular Intakes. J. Energy. Eng., 138: 237–245.

  6. The fate of new fosfamides in phase III studies in advanced soft tissue sarcoma

    NARCIS (Netherlands)

    Constantinidou, A.; Graaf, W.T.A. van der

    2017-01-01

    For decades, doxorubicin alone or in combination with ifosfamide has been used in advanced soft tissue sarcoma (STS). In 2014, a comparison of doxorubicin alone versus the combination with ifosfamide (in the randomised phase III EORTC 62012) showed no difference in overall survival (OS), but a

  7. Phase II study of ipilimumab in adolescents with unresectable stage III or IV malignant melanoma

    DEFF Research Database (Denmark)

    Geoerger, Birgit; Bergeron, Christophe; Gore, Lia

    2017-01-01

    BACKGROUND: Ipilimumab is approved for the treatment of advanced melanoma in adults; however, little information on the efficacy and safety of ipilimumab in younger patients is available. METHODS: Patients aged 12 to <18 years with previously treated or untreated, unresectable stage III or IV mal...

  8. A density functional theory study of arsenic immobilization by the Al(III)-modified zeolite clinoptilolite

    NARCIS (Netherlands)

    Awuah, Joel B.; Dzade, N.Y.; Tia, Richard; Adei, Evans; Kwakye-Awuah, Bright; Catlow, C. Richard A.; de Leeuw, Nora H.

    2016-01-01

    We present density functional theory calculations of the adsorption of arsenic acid (AsO(OH)3) and arsenous acid (As(OH)3) on the Al(III)-modified natural zeolite clinoptilolite under anhydrous and hydrated conditions. From our calculated adsorption energies, we show that adsorption of both arsenic

  9. [Immunohistochemical studies of collagen types I, III and IV distribution and the expression of procollagen III peptide in papillary carcinomas of the thyroid].

    Science.gov (United States)

    Katoh, R; Ono, S; Sasaki, J; Takayama, K; Nishio, H; Tomichi, N; Yagawa, K

    1990-08-01

    Collagen types I, III and IV and procollagen III peptide (P III P) were examined immunohistochemically in 38 papillary carcinomas of the thyroid. The immunoreactivity to both type I and type III collagen was diffuse and abundantly observed in the fibrous stroma, where it displayed a fibrillar and/or granular pattern with little difference in the intensity of the staining. The immunoreactivity to collagen type IV was localized in the basement membrane of the vessels and partly in the tumor cell nests. A distinctive cytoplasmic immunoreactivity to P III P was observed in the cancer cells and the fibroblasts in all of the 38 papillary carcinomas, specifically an intense and extensive immunoreactivity by the cancer cells present in tumors having fibrosclerosing stroma and/or showing an extensive local invasion. Thus, it is conceivable that stromal collagen in a papillary carcinoma can be produced by not only the fibroblasts but also by tumor cells and its productivity could be affected by the degree of the tumoral invasion.

  10. A test-bed modeling study for wave resource assessment

    Science.gov (United States)

    Yang, Z.; Neary, V. S.; Wang, T.; Gunawan, B.; Dallman, A.

    2016-02-01

    Hindcasts from phase-averaged wave models are commonly used to estimate standard statistics used in wave energy resource assessments. However, the research community and wave energy converter industry is lacking a well-documented and consistent modeling approach for conducting these resource assessments at different phases of WEC project development, and at different spatial scales, e.g., from small-scale pilot study to large-scale commercial deployment. Therefore, it is necessary to evaluate current wave model codes, as well as limitations and knowledge gaps for predicting sea states, in order to establish best wave modeling practices, and to identify future research needs to improve wave prediction for resource assessment. This paper presents the first phase of an on-going modeling study to address these concerns. The modeling study is being conducted at a test-bed site off the Central Oregon Coast using two of the most widely-used third-generation wave models - WaveWatchIII and SWAN. A nested-grid modeling approach, with domain dimension ranging from global to regional scales, was used to provide wave spectral boundary condition to a local scale model domain, which has a spatial dimension around 60km by 60km and a grid resolution of 250m - 300m. Model results simulated by WaveWatchIII and SWAN in a structured-grid framework are compared to NOAA wave buoy data for the six wave parameters, including omnidirectional wave power, significant wave height, energy period, spectral width, direction of maximum directionally resolved wave power, and directionality coefficient. Model performance and computational efficiency are evaluated, and the best practices for wave resource assessments are discussed, based on a set of standard error statistics and model run times.

  11. PICASSO III: A Phase III, Placebo-Controlled Study of Doxorubicin With or Without Palifosfamide in Patients With Metastatic Soft Tissue Sarcoma.

    Science.gov (United States)

    Ryan, Christopher W; Merimsky, Ofer; Agulnik, Mark; Blay, Jean-Yves; Schuetze, Scott M; Van Tine, Brian A; Jones, Robin L; Elias, Anthony D; Choy, Edwin; Alcindor, Thierry; Keedy, Vicki L; Reed, Damon R; Taub, Robert N; Italiano, Antoine; Garcia Del Muro, Xavier; Judson, Ian R; Buck, Jill Y; Lebel, Francois; Lewis, Jonathan J; Maki, Robert G; Schöffski, Patrick

    2016-11-10

    Purpose Palifosfamide is the active metabolite of ifosfamide and does not require prodrug activation, thereby avoiding the generation of toxic metabolites. The PICASSO III trial compared doxorubicin plus palifosfamide with doxorubicin plus placebo in patients who had received no prior systemic therapy for metastatic soft tissue sarcoma. Patients and Methods Patients were randomly assigned 1:1 to receive doxorubicin 75 mg/m2 intravenously day 1 plus palifosfamide 150 mg/m2/d intravenously days 1 to 3 or doxorubicin plus placebo once every 21 days for up to six cycles. The primary end point was progression-free survival (PFS) by independent radiologic review. Results In all, 447 patients were randomly assigned to receive doxorubicin plus palifosfamide (n = 226) or doxorubicin plus placebo (n = 221). Median PFS was 6.0 months for doxorubicin plus palifosfamide and 5.2 months for doxorubicin plus placebo (hazard ratio, 0.86; 95% CI, 0.68 to 1.08; P = .19). Median overall survival was 15.9 months for doxorubicin plus palifosfamide and 16.9 months for doxorubicin plus placebo (hazard ratio, 1.05; 95% CI, 0.79 to 1.39; P = .74). There was a higher incidence of grade 3 to 4 adverse events in the doxorubicin plus palifosfamide arm (63.6% v 50.9%) including a higher rate of febrile neutropenia (21.4% v 12.6%). Conclusion No significant difference in PFS was observed in patients receiving doxorubicin plus palifosfamide compared with those receiving doxorubicin plus placebo. The observed median PFS and overall survival in this large, international study can serve as a benchmark for future studies of doxorubicin in metastatic soft tissue sarcoma.

  12. A fluorescence study on the complexation of Sm(iii), Eu(iii) and Tb(iii) with tetraalkyldiglycolamides (TRDGA) in aqueous solution, in solid state, and in solvent extraction.

    Science.gov (United States)

    Kou, Fei; Yang, Suliang; Qian, Hongjuan; Zhang, Lihua; Beavers, Christine M; Teat, Simon J; Tian, Guoxin

    2016-11-22

    Tetraalkyldiglycolamide (TRDGA) ligands have potential utilization for the separation of actinide and lanthanide ions in the nuclear industry as chelates in aqueous solution if water-soluble or as extractants in organic solvents if water-insoluble. Here, a spectral titration method is extensively applied to investigating the complexation of fluorescent Sm(iii), Eu(iii), and Tb(iii) with TRDGA ligands in aqueous solutions and a solvent extraction system. In aqueous solutions using N,N,N',N'-tetramethyldiglycolamide (TMDGA, LI) as chelate, three successive complex species of Ln(iii), including [LnLI]3+, [LnL]3+, and [LnL]3+, are identified for each Ln(iii) (Ln = Sm, Eu, and Tb), and their stability constants are determined with fluorescence spectral titration method at 25 °C in 1 M NaNO3. The coordination mode in [LnL]3+ is illustrated by single-crystal structures of the solid compounds LnL(ClO4)3 (Ln = Sm, Eu, Tb, and LI = TMDGA) grown from aqueous solutions by slow evaporation. The crystal structures show that in the complexes Ln(iii) ions are coordinated by nine oxygen atoms from three tridentate LI ligands in a distorted tricapped trigonal prism geometry. To provide parallels to solvent extraction chemistry, the extracted Ln(iii) complexes with N,N'-dimethyl-N,N'-dioctyldiglycolamide (DMDODGA, LII, a lipophilic analogue of TMDGA) are prepared, and the fluorescence spectra are collected as well for comparison. The fluorescence spectra of the extracted Ln(iii) complexes with LII in an organic phase of 40-60% (v/v) n-octanol-kerosene are nearly identical to the corresponding deconvoluted spectra of [LnL]3+ in aqueous solution. The similarity in fluorescence spectra suggests that Ln(iii) ion in the extracted complexes is also coordinated by three tridentate LII ligands and that the nitrate anions acting just as counterions do not directly bond to Ln(iii) in the organic phase of solvent extraction.

  13. Renal outcomes in mixed proliferative and membranous lupus nephritis (Class III/IV + V): A long-term observational study.

    Science.gov (United States)

    Ikeuchi, Hidekazu; Hiromura, Keiju; Kayakabe, Ken; Tshilela, Kadiombo Anastasie; Uchiyama, Kazuhiko; Hamatani, Hiroko; Sakairi, Toru; Kaneko, Yoriaki; Maeshima, Akito; Nojima, Yoshihisa

    2016-11-01

    In this study, we aimed to assess the effect of combination of proliferative and membranous lesions (Class III + V or IV + V) on renal outcomes as an independent category distinct from Class III and IV. We retrospectively analyzed 103 Japanese patients (14 male and 89 female) with Class III/IV LN, with or without Class V, who underwent renal biopsy and were treated at our institution. Renal endpoint was defined as doubling of serum creatinine or end-stage renal disease (ESRD). The number of patients in each group was as follows: pure Class III/IV, 81 patients and mixed Class III/IV + V, 22 patients. During a median follow-up period of 125.0 months, 10 patients developed renal endpoint: five had Class III/IV LN and five had a combination of Class III/IV + V. Kaplan-Meier analyses demonstrated that patients with mixed Class III/IV + V LN had significantly poorer renal outcomes than patients with Class III/IV LN. Multivariate Cox regression analyses identified serum creatinine, active and chronic lesions (A/C), and mixed Class III/IV + V) as independent risk factors for poor renal outcomes. This study demonstrated a combination of proliferative and membranous LN (ISN/RPS Class III/IV + V) predicts poor renal outcomes.

  14. Evaluation of hydrophobic treatments applied to stones used in andalusian cathedrals. III.-Accelerated weathering test with polluted atmosphere

    Directory of Open Access Journals (Sweden)

    Villegas Sánchez, R.

    1993-12-01

    Full Text Available SUMMARY In this work we study the weathering resistance of samples of five types of stone used in Andalusian Cathedrals, treated with six water repellent products, by subjecting the samples to a SO2 polluted atmosphere. To evaluate the alteration of the samples, besides visual observation of macroscopic aspect, changes in weight and the quantity of sulfate that remains on the surface have been measured. Also properties related with water have been measured after the test to determine if there have been any changes in the hydrophobic characteristics.

    En el presente artículo se estudia el comportamiento de muestras de cinco tipos de piedra utilizados en catedrales andaluzas, tratadas con seis productos hidrófugos, sometiéndolas a un ensayo acelerado de alteración en atmósfera contaminada con SO2 . Para evaluar la alteración, además de la observación visual de las manifestaciones macroscópicas, se ha medido la variación de peso de las muestras expuestas y la cantidad de sulfato que permanece en la superficie tras el ensayo. Así mismo, se han detectado los cambios experimentados en las propiedades hidrófugas conferidas por los tratamientos, mediante la medida de propiedades relacionadas con el movimiento del agua.

  15. Rapid and sensitive lateral flow immunoassay method for determining alpha fetoprotein in serum using europium (III) chelate microparticles-based lateral flow test strips

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Rong-Liang; Xu, Xu-Ping; Liu, Tian-Cai; Zhou, Jian-Wei; Wang, Xian-Guo; Ren, Zhi-Qi [Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong (China); Hao, Fen [DaAn Gene Co. Ltd. of Sun Yat-sen University, 19 Xiangshan Road, Guangzhou 510515 (China); Wu, Ying-Song, E-mail: wg@smu.edu.cn [Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong (China)

    2015-09-03

    Alpha-fetoprotein (AFP), a primary marker for many diseases including various cancers, is important in clinical tumor diagnosis and antenatal screening. Most immunoassays provide high sensitivity and accuracy for determining AFP, but they are expensive, often complex, time-consuming procedures. A simple and rapid point-of-care system that integrates Eu (III) chelate microparticles with lateral flow immunoassay (LFIA) has been developed to determine AFP in serum with an assay time of 15 min. The approach is based on a sandwich immunoassay performed on lateral flow test strips. A fluorescence strip reader was used to measure the fluorescence peak heights of the test line (H{sub T}) and the control line (H{sub C}); the H{sub T}/H{sub C} ratio was used for quantitation. The Eu (III) chelate microparticles-based LFIA assay exhibited a wide linear range (1.0–1000 IU mL{sup −1}) for AFP with a low limit of detection (0.1 IU mL{sup −1}) based on 5ul of serum. Satisfactory specificity and accuracy were demonstrated and the intra- and inter-assay coefficients of variation (CV) for AFP were both <10%. Furthermore, in the analysis of human serum samples, excellent correlation (n = 284, r = 0.9860, p < 0.0001) was obtained between the proposed method and a commercially available CLIA kit. Results indicated that the Eu (III) chelate microparticles-based LFIA system provided a rapid, sensitive and reliable method for determining AFP in serum, indicating that it would be suitable for development in point-of-care testing. - Highlights: • Europium (III) chelate microparticles was used as a label for LIFA. • Quantitative detection by using H{sub T}/H{sub C} ratio was achieved. • LIFA for simple and rapid AFP detection in human serum. • The sensitivity and linearity was more excellent compared with QD-based ICTS. • This method could be developed for rapid point-of-care screening.

  16. Função executiva em idosos: um estudo utilizando subtestes da escala WAIS-III Executive functions in elderly: a study using WAIS-III Subtests Scale

    Directory of Open Access Journals (Sweden)

    Eliane Ferreira Carvalho Banhato

    2007-06-01

    Full Text Available Avaliar funções executivas é relevante por apresentarem declínio precoce com a idade. Disponibilizar instrumentos para pesquisa e avaliação de idosos é necessário em face do aumento dessa população. Este estudo transversal objetivou avaliar funções executivas de idosos utilizando cinco subtestes da WAIS-III, identificando associações com idade, gênero e escolaridade. A amostra comunitária constituiu-se de 346 idosos com média etária de 74,14 anos (DP = 8,49 e escolaridade de 7,2 anos (DP = 4,5. Mediu-se validade de construto com testes de Fluência Verbal (convergente e CES-D (divergente. Univariadas determinaram diferença significativa segundo gênero, com melhor desempenho masculino. Idade correlacionou-se negativa e significativamente com tarefas executivas. Escolaridade afetou a velocidade de processamento, mas não a atenção, raciocínio e organização perceptovisuomotora. Concluiu-se pela adequação dos subtestes para avaliação executiva de idosos. Recomenda-se estabelecimento de pontos de corte para possibilitar diferenciação entre envelhecimento normal e patológico.Evaluating executive functions is relevant because of their presenting premature decline with age. It's necessary to make instruments for research and evaluation of elderly people available due to the increase of this population. This transversal study had as its objective the evaluation of executive functions of elderly people using five sub tests of WAIS-III identifying associations with age, gender and level of instruction. The communitarian sample consisted of 346 elderly people with average age of 74,14 years (DP = 8,49 and level of instruction of 7,2 years (DP = 4,5. The validity of construct was measured with tests of Verbal Fluency (convergent and CES-D (divergent. Univariate Analysis have determined significant difference according to gender, with better masculine performance. Age correlated negatively and significantly to executive tasks

  17. Design, analysis, and testing of a microdot apodizer for the apodized pupil Lyot coronagraph. III. Application to extremely large telescopes

    Science.gov (United States)

    Martinez, P.; Dorrer, C.; Kasper, M.; Boccaletti, A.; Dohlen, K.

    2010-09-01

    Context. The apodized-pupil Lyot coronagraph is one of the most advanced starlight cancellation concepts studied intensively in the past few years. Extreme adaptive optics instruments built for present-day 8m class telescopes will operate with such coronagraph for imagery and spectroscopy of faint stellar companions. Aims: Following the development of an early demonstrator in the context of the VLT-SPHERE project (~2012), we manufactured and tested a second APLC prototype in microdots designed for extremely large telescopes. This study has been conducted in the context of the EPICS instrument project for the European-ELT (~2018), where a proof of concept is required at this stage. Methods: Our prototype was specifically designed for the European-ELT pupil, taking its large central obscuration ratio (30%) into account. Near-IR laboratory results are compared with simulations. Results: We demonstrate good agreement with theory. A peak attenuation of 295 was achieved, and contrasts of 10-5 and 10-6 were reached at 7 and 12 λ/D, respectively. We show that the APLC is able to maintain these contrasts with a central obscuration ratio of the telescope in the range 15% to 30%, and we report that these performances can be achieved in a wide wavelength bandpass (Δλ/λ = 24%). In addition, we report improvement to the accuracy of the control of the local transmission of the manufactured microdot apodizer to that of the previous prototype. The local profile error is found to be less than 2%. Conclusions: The maturity and reproducibility of the APLC made with microdots is demonstrated. The apodized pupil Lyot coronagraph is confirmed to be a pertinent candidate for high-contrast imaging with ELTs.

  18. CHROMIUM HAZARD AND RISK ASSESSMENT: NEW INSIGHTS FROM A DETAILED SPECIATION STUDY IN A STANDARD TEST MEDIUM.

    Science.gov (United States)

    Aharchaou, Imad; Py, Jean-Sebastien; Cambier, Sebastien; Loizeau, Jean-Luc; Cornelis, Geert; Rousselle, Philippe; Battaglia, Eric; Vignati, Davide A L

    2017-11-18

    Despite the consensus about the importance of chemical speciation in controlling the bioavailability and ecotoxicity of trace elements, detailed speciation studies during laboratory ecotoxicity testing remain scarce, contributing to uncertainty when extrapolating laboratory findings to real field situations in risk assessment. We characterized the speciation and ecotoxicological effects of Cr(III) and Cr(VI) in the ISO medium for algal ecotoxicity testing. Total and dissolved (<0.22 μm) Cr concentrations showed little variability in media spiked with Cr(VI) , while dissolved Cr concentration decreased by as much as 80% over 72 hours in medium amended with Cr(III) . Analyses by ion chromatography ICP-MS highlighted the absence of redox interconversion between Cr(III) or Cr(VI) both in the presence and absence of algal cells (Raphidocelis subcapitata). Furthermore, the concentration of ionic Cr(III) dropped below detection limits in less than 2 hours with the corresponding formation of carbonate complexes and Cr hydroxides. Precipitation of Cr(III) in the form of colloidal particles of variable diameters was confirmed by nanoparticle tracking analysis, spICP-MS and single particle counting. In terms of time weighted dissolved (<0.22 μm) Cr concentration, Cr(III) was 4 to 10 times more toxic than Cr(VI) . However, Cr(III) ecotoxicity could arise from interactions between free ionic Cr(III) and algae at the beginning of the test, from the presence of Cr-bearing nanoparticles or a combination of the two. Future ecotoxicological studies must pay more attention to Cr speciation to reliably compare the ecotoxicity of Cr(III) and Cr(VI) . This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  19. 4 August 2011 - Austrian Head of Protocol, Directorate General III, Federal Ministry of Science and Research I. Friedrich (3rd from left) in the LHC superconducting magnet test hall with M. Benedkit, C. Wulz and C. Fabjan.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    4 August 2011 - Austrian Head of Protocol, Directorate General III, Federal Ministry of Science and Research I. Friedrich (3rd from left) in the LHC superconducting magnet test hall with M. Benedkit, C. Wulz and C. Fabjan.

  20. Acoustic Detection of Faults and Degradation in a High-Bypass Turbofan Engine during VIPR Phase III Testing

    Science.gov (United States)

    Boyle, Devin K.

    2017-01-01

    The Vehicle Integrated Propulsion Research (VIPR) Phase III project was executed at Edwards Air Force Base, California, by the National Aeronautics and Space Administration and several industry, academic, and government partners in the summer of 2015. One of the research objectives was to use external radial acoustic microphone arrays to detect changes in the noise characteristics produced by the research engine during volcanic ash ingestion and seeded fault insertion scenarios involving bleed air valves. Preliminary results indicate the successful acoustic detection of suspected degradation as a result of cumulative exposure to volcanic ash. This detection is shown through progressive changes, particularly in the high-frequency content, as a function of exposure to greater cumulative quantities of ash. Additionally, detection of the simulated failure of the 14th stage stability bleed valve and, to a lesser extent, the station 2.5 stability bleed valve, to their fully-open fail-safe positions was achieved by means of spectral comparisons between nominal (normal valve operation) and seeded fault scenarios.

  1. Test Plan - Solids Accumulation Scouting Studies

    Energy Technology Data Exchange (ETDEWEB)

    Duignan, M. R.; Steeper, T. J.; Steimke, J. L.; Fowley, M. D.

    2012-05-10

    This plan documents the highlights of the Solids Accumulations Scouting Studies test; a project, from Washington River Protection Solutions (WRPS), that began on February 1, 2012. During the last 12 weeks considerable progress has been made to design and plan methods that will be used to estimate the concentration and distribution of heavy fissile solids in accumulated solids in the Hanford double-shell tank (DST) 241-AW-105 (AW-105), which is the primary goal of this task. This DST will be one of the several waste feed delivery staging tanks designated to feed the Pretreatment Facility (PTF) of the Waste Treatment and Immobilization Plant (WTP). Note that over the length of the waste feed delivery mission AW-105 is currently identified as having the most fill empty cycles of any DST feed tanks, which is the reason for modeling this particular tank. At SRNL an existing test facility, the Mixing Demonstration Tank, which will be modified for the present work, will use stainless steel particles in a simulant that represents Hanford waste to perform mock staging tanks transfers that will allow solids to accumulate in the tank heel. The concentration and location of the mock fissile particles will be measured in these scoping studies to produce information that will be used to better plan larger scaled tests. Included in these studies is a secondary goal of developing measurement methods to accomplish the primary goal. These methods will be evaluated for use in the larger scale experiments. Included in this plan are the several pretest activities that will validate the measurement techniques that are currently in various phases of construction. Aspects of each technique, e.g., particle separations, volume determinations, topographical mapping, and core sampling, have been tested in bench-top trials, as discussed herein, but the actual equipment to be employed during the full test will need evaluation after fabrication and integration into the test facility.

  2. Estudo longitudinal das habilidades intelectuais de idosos avaliados com a WAIS-III Longitudinal study of intellectual abilities of elderly people assessed by WAIS-III

    Directory of Open Access Journals (Sweden)

    Ana Carolina Zeferino Menezes

    2011-01-01

    Full Text Available Dados indicam que o envelhecimento, ainda que saudável, acarreta um declínio normal no desempenho intelectual. O presente estudo teve por objetivo investigar o desenvolvimento intelectual de idosos em diferentes domínios avaliados pela WAIS-III. A partir de um delineamento longitudinal, 47 participantes foram divididos em duas faixas etárias: idosos-jovens (até 74 anos e idosos-idosos (acima de 75 anos e seus desempenhos foram comparados após oito anos de intervalo. Resultados mostraram que idosos-jovens apresentaram ganhos nas habilidades avaliadas, embora em apenas dois índices estes tenham sido estatisticamente significativos. Com relação às capacidades de compreensão verbal e linguagem, os ganhos eram esperados. Já Memória, Organização Perceptual, Velocidade de Processamento, QI de Execução e Total não se comportaram como grande parte dos estudos reporta. Resultados para os idosos-idosos estão de acordo com a literatura: habilidades vulneráveis (organização perceptual, aprendizagem, memória, resolução de problemas e velocidade de processamento tiveram decréscimos após os oito anos entre as avaliações. Embora nem todos os resultados tenham sido significativos, corroboram dados de pesquisas que definem a idade de declínios significativos após os 75 anos. Concluindo, os resultados indicaram que os idosos não apresentaram declínio nas habilidades intelectuais avaliadas até a idade de 74 anos, a partir de quando alguma perda foi encontrada. A velocidade de processamento foi a única habilidade que apresentou declínio significativo. Portanto, as variações nos desempenhos não caracterizam um padrão de declínio generalizado, ou seja, não ocorrem em todas as habilidades e variam conforme a idade.Data have indicated that aging, even if in a healthy process, lead to a normal decrease in cognitive performance. The current study aims at investigating the intellectual development of elderly people in different

  3. Treatability Study Pilot Test Operation Field Photos

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jun [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-11-01

    Photos in each group are in chronological order as captured: Group I Tank Platform Setup, November 14, 2017; Group II Tank Setup, November 15, 2017; Group III Aboveground Injestion System (AIS) Setup, November 20, 2017; Group IV Chemical Mixing, November 21, 2017; Group V KB-1 Bacteria Injection, November 27, 2017; Group VI Miscellaneous.

  4. Performance of a Rapid and Simple HIV Testing Algorithm in a Multicenter Phase III Microbicide Clinical Trial▿

    OpenAIRE

    Crucitti, Tania; Taylor, Doug; Beelaert, Greet; Fransen, Katrien; Van Damme, Lut

    2011-01-01

    A multitest sequential algorithm based on rapid and simple (R/S) assays was applied for the diagnosis of HIV infection among participants in a phase 3 microbicide effectiveness trial. HIV testing was performed on finger-prick blood samples obtained from patients after their enrollment in the trial. The specimens were tested in a serial procedure using three different rapid tests (Determine HIV-1/2 [Abbott], SD Bioline HIV-1/2 3.0 [Standard Diagnostics], and Uni-Gold HIV [Trinity Biotech]). In...

  5. Body coordination test for children (KTK: Applications and normative studies

    Directory of Open Access Journals (Sweden)

    Alice Sá Carneiro Ribeiro

    2012-10-01

    Full Text Available The aims of the present review were: i to demonstrate the use of the Body Coordination Test for Children (Körperkoordinationstest Für Kinder - KTK in diverse populations of children, ii to describe studies that developed reference values for KTK, and iii to ascertain the existence of reference values of KTK for Brazilian children’s motor coordination. The selection of publications was performed between April and June (2010 and the Pubmed, Lilacs and www.google.com/scholar databases were employed. The results indicated that the KTK is an evaluation instrument for motor coordinative performance appropriate to be applied in different childish populations, such as Down syndrome bearers. Most studies that constructed reference values for their childish population showed lower mean values than those established from the group of German children from whom originated the reference data of KTK. This fact demonstrates the importance of the construction of normative data in different countries in view of diverse biological, social, economical and cultural characteristics to be considered. Finally, it was observed the absence of reference data of KTK for Brazilian children, however, it is undeniable the importance of applying the test to evaluate the global motor coordination of these children.

  6. Spectroscopic studies on the interaction of chromium (VI) and chromium (III) with keyhole limpet hemocyanin.

    Science.gov (United States)

    Fan, Yulan; Zeng, Guidi; Liu, Jingyi; Chen, Huifang; Xue, Jun; Wu, Yongquan; Li, Xun

    2017-03-01

    The interactions of keyhole limpet hemocyanin (KLH) with chromium nitrate, potassium dichromate, and chromate were investigated using fluorescence, UV-vis absorption and circular dichroism (CD) spectroscopy under simulated physiological conditions. The experimental results showed that the different forms of chromium could quench the intrinsic fluorescence of KLH following a static quenching mechanism rather than by dynamic collision, which indicated that a Cr-KLH complex was formed. The Stern-Volmer quenching constants for the interaction indicated that the binding reaction of KLH with Cr(VI) was stronger the binding of KLH with Cr(III). The thermodynamic values for binding of Cr(VI) to KLH are ΔH > 0 and ΔS > 0. By contrast, the values for the interaction of Cr(III) with KLH are ΔH chromium. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  7. Impact of zeolite-Y framework on the geometry and reactivity of Ru (III) benzimidazole complexes - A DFT study

    Science.gov (United States)

    Selvaraj, Tamilmani; Rajalingam, Renganathan; Balasubramanian, Viswanathan

    2018-03-01

    A detailed comparative Density Functional Theory (DFT) study is made to understand the structural changes of the guest complex due to steric and electronic interactions with the host framework. In this study, Ru(III) benzimidazole and 2- ethyl Ru(III) benzimidazole complexes encapsulated in a supercage of zeolite Y. The zeolitic framework integrity is not disturbed by the intrusion of the large guest complex. A blue shift in the d-d transition observed in the UV-Visible spectroscopic studies of the zeolite encapsulated complexes and they shows a higher catalytic efficiency. Encapsulation of zeolite matrix makes the metal center more viable to nucleophilic attack and favors the phenol oxidation reaction. Based on the theoretical calculations, transition states and structures of reaction intermediates involved in the catalytic cycles are derived.

  8. A Study of King Richard III : Richard's Evil Dominates the Play

    OpenAIRE

    東, 勉; Tsutomu, HIGASHI

    2005-01-01

    This paper is one attempt to analyse the structure of Shakespeare's History Richard III and to consider Richard's evilness and the process of his obtaining the English crown and the way of his falling from it. There are many thematic and historical connections between the Henry VI trilogy and this play. This play is usually classified as a History. But this classification is still ambiguous because there are many phases of this play. This play has an ambivalent element between the tragedy and...

  9. Intelligent cruise control field operational test. Vol III, Performance of a string or cluster of ACC-equipped cars

    Science.gov (United States)

    1998-07-01

    This report is one element of a cooperative agreement between NHTSA and UMTRI entitled Intelligent Cruise Control (ICC) Field Operational Test (FOT). It addresses the operation of a serial string or dense cluster of passenger cars equipped with a new...

  10. Genetic and expression studies of SMN2 gene in Russian patients with spinal muscular atrophy type II and III

    Directory of Open Access Journals (Sweden)

    Schiöth Helgi B

    2011-07-01

    Full Text Available Abstract Background Spinal muscular atrophy (SMA type I, II and III is an autosomal recessive neuromuscular disorder caused by mutations in the survival motor neuron gene (SMN1. SMN2 is a centromeric copy gene that has been characterized as a major modifier of SMA severity. SMA type I patients have one or two SMN2 copies while most SMA type II patients carry three SMN2 copies and SMA III patients have three or four SMN2 copies. The SMN1 gene produces a full-length transcript (FL-SMN while SMN2 is only able to produce a small portion of the FL-SMN because of a splice mutation which results in the production of abnormal SMNΔ7 mRNA. Methods In this study we performed quantification of the SMN2 gene copy number in Russian patients affected by SMA type II and III (42 and 19 patients, respectively by means of real-time PCR. Moreover, we present two families consisting of asymptomatic carriers of a homozygous absence of the SMN1 gene. We also developed a novel RT-qPCR-based assay to determine the FL-SMN/SMNΔ7 mRNA ratio as SMA biomarker. Results Comparison of the SMN2 copy number and clinical features revealed a significant correlation between mild clinical phenotype (SMA type III and presence of four copies of the SMN2 gene. In both asymptomatic cases we found an increased number of SMN2 copies in the healthy carriers and a biallelic SMN1 absence. Furthermore, the novel assay revealed a difference between SMA patients and healthy controls. Conclusions We suggest that the SMN2 gene copy quantification in SMA patients could be used as a prognostic tool for discrimination between the SMA type II and SMA type III diagnoses, whereas the FL-SMN/SMNΔ7 mRNA ratio could be a useful biomarker for detecting changes during SMA pharmacotherapy.

  11. First-principles study lone-pair effects of Sb (III)-S chromophore influence on SHG response in quaternary potassium containing silver antimony sulfides

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Junben [Key Laboratory of Functional Materials and Devices for Special Environments of CAS,, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics & Chemistry of CAS, 40-1 South Beijing Road, Urumqi 830011 (China); School of Physics Science and Technology, Xinjiang University, Urumqi 830046 (China); Su, Xin; Hou, Dianwei; Lei, Binghua [Key Laboratory of Functional Materials and Devices for Special Environments of CAS,, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics & Chemistry of CAS, 40-1 South Beijing Road, Urumqi 830011 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Yang, Zhihua, E-mail: zhyang@ms.xjb.ac.cn [Key Laboratory of Functional Materials and Devices for Special Environments of CAS,, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics & Chemistry of CAS, 40-1 South Beijing Road, Urumqi 830011 (China); Pan, Shilie, E-mail: slpan@ms.xjb.ac.cn [Key Laboratory of Functional Materials and Devices for Special Environments of CAS,, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics & Chemistry of CAS, 40-1 South Beijing Road, Urumqi 830011 (China)

    2017-05-15

    First-principles studies of the geometric structures, electronic structures and optical properties of non-centrosymmetrical (NCS) KAg{sub 2}SbS{sub 4}, K{sub 2}AgSbS{sub 4} and K{sub 2}Ag{sub 3}Sb{sub 3}S{sub 7} and centrosymmetrical (CS) KAg{sub 2}SbS{sub 3} and K{sub 3}Ag{sub 9}Sb{sub 4}S{sub 12} have been performed by means of density functional theory. It is indicated that although they have similarity in their anionic groups and, the electronic structures, prominent features of the optical anisotropy or second-order nonlinear optical (NLO) susceptibilities are apparently different. The calculated birefringences are 0.0537, 0.0343, 0.1324, 0.2217 and 0.0604 which are attributed to the different anionic groups [SbS{sub 3}] and triangles [AgS{sub 3}]. Also, the calculated NLO responses are about 0.5×, 1.0× and 2.0× times than that commercial AgGaS{sub 2} (AGS, d{sub 36}=11 pm/V) for K{sub 2}AgSbS{sub 4}, KAg{sub 2}SbS{sub 4} and K{sub 2}Ag{sub 3}Sb{sub 3}S{sub 7}, respectively. In comparison with the absolute magnitude of second harmonic generation (SHG) coefficients, the order K{sub 2}Ag{sub 3}Sb{sub 3}S{sub 7}>KAg{sub 2}SbS{sub 4}>K{sub 2}AgSbS{sub 4} is clearly established in the SHG response. Further analysis based on the real-space atom-cutting method reveals that the main sources of the SHG properties of these compounds are from the Sb-S group, especially K{sub 2}Ag{sub 3}Sb{sub 3}S{sub 7} is mainly attributed to the lone pair stereochemical activity of Sb (III)-S group. - Graphical abstract: Compounds K{sub 2}AgSbS{sub 4}, KAg{sub 2}SbS{sub 4} and K{sub 2}Ag{sub 3}Sb{sub 3}S{sub 7} exhibit second-order NLO response: 15×, 30× and 62× times than that KDP (KH{sub 2}PO{sub 4}, d{sub 36}=0.39 pm/V), respectively. First-principles methods reveal that the large SHG response of K{sub 2}Ag{sub 3}Sb{sub 3}S{sub 7} is dominated by the Sb-S chromophore with lone pairs.

  12. Flow tests of the Willis Hulin Well. Volume III. Final report for the period October 1985--October 1990

    Energy Technology Data Exchange (ETDEWEB)

    Randolph, P.L.; Hayden, C.G.; Rogers, L.A.

    1992-02-01

    The initial flow test of the Hulin well was done to obtain brine and gas samples and to get a first measure of the reservoir properties. The 20,602 to 20,690-foot interval was perforated and tested in two short-term draw-down and buildup tests. This zone had an initial pressure of 17,308 psia and temperature of 339 F. The total dissolved solids of 207,000 mg/L (mostly sodium chloride) is higher than for previously tested Gulf Coast geopressured-geothermal wells. The gas content in the brine of 31 to 32 SCF/STB indicates that the brine is at or near saturation with natural gas. The permeability, as deduced from the draw-down and buildup tests, is 13 md for the lower 80-foot-thick sand member. The duration of the tests was too short to determine the lateral extent of the reservoir; but declining measured values for static bottomhole pressure prior to each flow test suggests a relatively small reservoir. When the uppermost interval in the zone of interest (20,220 to 20,260 feet) was perforated such that flow from this zone would commingle with flow from the lower zone, little to no free gas was observed. It had been speculated before the test that there might be free gas in this upper zone. These speculations were generally deduced from logs after assuming the formation contained brine that had a salinity between 70,000 and 100,000 mg/L. The actual salinity was more than twice that number. it is now apparent that the amount of free gas, if any, is too small to make a significant contribution to production in a short-term test. This does not preclude the possibility of mobilization of gas by higher drawdown or coning down from an offsetting gas cap in one or more of the sand members. However, there was no evidence that this was occurring in this test. No measurements of the reservoir parameters, such as permeability, were made for the shallowest interval tested. But substantially lower drawdown for the commingled zones suggests either higher permeability or lower skin

  13. [Phase III study of chemotherapy in low-malignancy non-Hodgkin's lymphomas: comparison of vincristine-vindesine combination chemotherapy].

    Science.gov (United States)

    Heim, M E; Fritze, D; Ho, A D; Mebes, W; Abel, U

    1987-12-01

    In a phase-III study in non-Hodgkin's lymphoma of low malignancy we compared a combination therapy with vincristine (COP) with a vindesine combination (CEP). Remission rates, duration of remission and survival was favorable for the CEP combination without reaching the level of significance. The peripheral neurotoxicity of grade 2 and 3 according to WHO criteria was observed more frequently with vincristine. The vincristine-induced neurotoxicity in 6 patients was not impaired when a change was made to vindesine treatment.

  14. Complexation of Eu(III) with cucurbit[n]uril, n = 5 and 7: a thermodynamic and structural study.

    Science.gov (United States)

    Rawat, Neetika; Kar, Aishwarya; Bhattacharyya, A; Rao, Ankita; Nayak, S K; Nayak, C; Jha, S N; Bhattacharyya, D; Tomar, B S

    2015-03-07

    Cucurbit[n]urils (CBn) are a new class of macrocyclic cage compounds capable of binding organic and inorganic species, owing to their unique pumpkin like structure comprising of both a hydrophobic cavity and a hydrophilic portal. The thermodynamics of the complexation of Eu(III) with CBn of a different cavity size viz. cucurbit[5]uril (CB5) and cucurbit[7]uril (CB7) has been studied by UV-Vis spectroscopy and calorimetry at 25 °C whereas the structure of the complexes was investigated using time resolved fluorescence spectroscopy (TRFS) and extended X-ray absorption fine structure spectroscopy (EXAFS) in a formic acid-water mixture (50 wt%). This is the first report on the structural investigation of Eu-CBn complexes in solution. The thermodynamic data (ΔG, ΔH and ΔS) for Eu(III) complexation with CBn reveal the formation of a 1 : 1 complex with CB5, while both 1 : 1 and 1 : 2 complexes are observed with CB7. The signatures of these species are observed in ESI-MS measurements, which corroborates with the species postulated in thermodynamic studies. The complexation reactions are found to be driven by ΔS as ΔH is either small negative or positive indicating the formation of inner sphere complexes, which is in line with TRFS and EXAFS results. These studies show that Eu(III) caps one of the CB5 portals by binding with all the carbonyl groups in the 1 : 1 Eu-CB5 complex, whereas in the 1 : 1 Eu-CB7 complex, Eu(III) interacts with only a few of the carbonyl groups of CB7. The computational studies (DFT calculations) on Eu-CB5 and Eu-CB7 complexes further support the experimental data.

  15. Testing Premixed Turbulent Combustion Models by Studying Flame Dynamics

    Directory of Open Access Journals (Sweden)

    Andrei N. Lipatnikov

    2009-03-01

    Full Text Available First, the following universal feature of premixed turbulent flame dynamics is highlighted: During an early stage of flame development, the burning velocity grows much faster than the mean flame brush thickness, because the two processes are controlled by the small-scale and large-scale turbulent eddies, respectively. Second, this feature of developing flames is exploited in order to test a number of different models of premixed turbulent combustion by theoretically and numerically studying an interaction of an initially laminar, planar, one-dimensional flame with a statistically stationary, planar, one-dimensional, and spatially uniform turbulent flow not affected by combustion. To test as many models as possible in a simple and unified manner, various combustion models are divided into three generalized groups: (i algebraic models, which invoke an algebraic expression for the mean rate of product creation, (ii gradient models, which involve a gradient-type source term in a balance equation for the mean combustion progress variable, and (iii two-equation models, which deal not only with a balance equation for the mean combustion progress variable but also with either a balance equation for the flame surface density or a balance equation for the mean scalar dissipation rate. Analytical and numerical results reported in the paper indicate that solely the gradient models are able to yield substantially different growth rates of the turbulent burning velocity and the mean flame brush thickness.

  16. Paris Prospective Study III: a study of novel heart rate parameters, baroreflex sensitivity and risk of sudden death.

    Science.gov (United States)

    Empana, Jean-Philippe; Bean, Kathy; Guibout, Catherine; Thomas, Frédérique; Bingham, Annie; Pannier, Bruno; Boutouyrie, Pierre; Jouven, Xavier

    2011-11-01

    Resting heart rate has been related to the risk of cardiovascular disease and sudden death in several large prospective studies. To investigate prospectively the association of novel heart rate parameters and of carotid artery stiffness with sudden death and other cardiovascular disease. The Paris Prospective Study III (PPS3) is a new, ongoing French prospective study. From June 2008 to December 2011, 10,000 men and women aged 50-75 years who will have a preventive medical check-up at the Centre d'Investigations Préventives et Cliniques in Paris (France), will be enrolled in the study, after signing an informed consent. In addition to the general health examination, each subject's heart rhythm will be recorded during the course of the health check-up (approximately 2(1/2) h) and an echo-tracking of the right carotid bulb will be performed by trained technicians. A bio bank and DNA bank will be established for further biomarker and genetic analyses. The occurrence of cardiovascular disease including acute coronary syndrome, stroke, peripheral artery disease and sudden death, and of mortality, of the participants will be followed up during 20 years. With an estimated mean annual rate of sudden death of 0.1% and its increasing incidence rate with age, between 250 and 300 sudden deaths are expected. This unique study should provide new insights into the regulation of heart rate and blood pressure and should enable to identify novel heart rate parameters that are associated with sudden death.

  17. Underground gasification for steeply dipping coal beds: Phase III. Quarterly progress report, April 1-June 30, 1981. [Rawlins Test 2

    Energy Technology Data Exchange (ETDEWEB)

    1981-12-01

    Preparations are being made for the August start-up of Rawlins Test 2. Site construction activities began May 4 with the mobilization of the construction subcontractor. The drilling program was completed this quarter with the installation of instrumentation wells. The Experimental Basis Document, PGA Operating Manual, and DAS Operating Manual have also been completed.

  18. Fatigue Lives of Specimens Representing Critical Locations in Mirage III Spars under Australian and Swiss Test Spectra,

    Science.gov (United States)

    1985-02-01

    short life specimens (BJ tOlD and BJI 5JB) tested at a scaling factor ofŖ.2 where there were multiple initiation sites fron tlie bottom of the chamfer...specimens. the primary fatigue crack development was from multiple initiation along the bore of the bolt hole. leading to a final crack shape

  19. Interpreting Personality Tests: A Clinical Manual for the MMPI-2, MCMI-III, CPI-R, and 16PF.

    Science.gov (United States)

    Craig, Robert J.

    This book provides step-by-step procedures for clinical personality interpretation to help mental health professionals determine the psychological health of their clients, determine maladjustment and problem behaviors, and reach a diagnosis. Each of the four chapters is devoted to one of the four key personality tests. These are: (1)…

  20. Corrective Action Investigation Plan for Corrective Action Unit 414: Clean Slate III Plutonium Dispersion (TTR) Tonopah Test Range, Nevada, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Patrick [Navarro, Las Vegas, NV (United States)

    2016-09-01

    Corrective Action Unit (CAU) 414 is located on the Tonopah Test Range, which is approximately 130 miles northwest of Las Vegas, Nevada, and approximately 40 miles southeast of Tonopah, Nevada. The CAU 414 site consists of the release of radionuclides to the surface and shallow subsurface from the conduct of the Clean Slate III (CSIII) storage–transportation test conducted on June 9, 1963. CAU 414 includes one corrective action site (CAS), TA-23-03CS (Pu Contaminated Soil). The known releases at CAU 414 are the result of the atmospheric dispersal of contamination from the 1963 CSIII test. The CSIII test was a nonnuclear detonation of a nuclear device located inside a reinforced concrete bunker covered with 8 feet of soil. This test dispersed radionuclides, primarily uranium and plutonium, on the ground surface. The presence and nature of contamination at CAU 414 will be evaluated based on information collected from a corrective action investigation (CAI). The investigation is based on the data quality objectives (DQOs) developed on June 7, 2016, by representatives of the Nevada Division of Environmental Protection; the U.S. Air Force; and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective action alternatives for CAU 414.

  1. Synthesis, spectroscopic characterization, solid state d.c. electrical conductivity and biological studies of some lanthanide(III chloride complexes with a heterocyclic Schiff base ligand

    Directory of Open Access Journals (Sweden)

    K. Mohanan

    2016-07-01

    Full Text Available Condensation of 2-hydroxy-1-naphthaldehyde with 2-amino-3-carboxyethyl-4,5-dimethylthiophene in 1:1 molar ratio, yielded a potentially tridentate Schiff base viz. 2-[N-(2′-hydroxy-1-naphthylideneamino]-3-carboxyethyl-4,5-dimethylthiophene (HNAT. This ligand formed complexes with lanthanum(III, cerium(III, praseodymium(III, neodymium(III, samarium(III, europium(III and gadolinium(III chloride under well defined conditions. These complexes were characterized through elemental analysis, molar conductance, magnetic moment measurements, IR, UV–Vis, FAB mass and 1H NMR spectral studies. Analytical data showed that all the metal complexes exhibited 1:1 metal–ligand ratio. Molar conductance values adequately confirmed the non-electrolytic nature of the metal complexes. The proton NMR spectral observations supplement the IR spectral assignments. The spectral data revealed that the ligand acted as neutral tridentate, coordinating to the metal ion through azomethine nitrogen, ester carbonyl and naphtholate oxygen without deprotonation. The ligand and its lanthanum(III chloride complex were subjected to XRD studies. The lanthanum(III chloride complex has undergone a facile transesterification reaction. The solid state d.c. electrical conductivity of some selected complexes were measured as a function of temperature, indicating the semiconducting nature of the metal complexes. The antimicrobial activities were examined by disk diffusion method against some pathogenic bacterial and fungal species.

  2. Test-retest studies in quantitative sensory testing

    DEFF Research Database (Denmark)

    Werner, M U; Petersen, M A; Bischoff, J M

    2013-01-01

    Quantitative sensory testing (QST) investigates the graded psychophysical response to controlled thermal, mechanical, electrical or chemical stimuli, allowing quantification of clinically relevant perception and pain thresholds. The methods are ubiquitously used in experimental and clinical pain...... research, and therefore, the need for uniform assessment procedures has been emphasised. However, varying consistency and transparency in the statistical methodology seem to occur in the QST literature. Sixteen publications, evaluating aspects of QST variability, from 2010 to 2012, were critically reviewed...

  3. Reduction of amorphous Fe(III)-hydroxide by binary microbial culture, a Moessbauer study

    Energy Technology Data Exchange (ETDEWEB)

    Chistyakova, N. I., E-mail: nchistyakova@yandex.ru; Rusakov, V. S.; Shapkin, A. A. [M.V. Lomonosov Moscow State University, Faculty of Physics (Russian Federation); Zhilina, T. N.; Zavarzina, D. G. [Russian Academy of Sciences, Winogradsky Institute of Microbiology (Russian Federation)

    2010-04-15

    Moessbauer investigations between 4.5 and 300 K of iron minerals formed during the growth of the binary culture containing two anaerobic alkaliphilic bacteria-dissimilatory iron-reducing Geoalkalibacter ferrihydriticus (strain Z-0531) and organotrophic Anaerobacillus alkalilacustre (strain Z- 0521), have been carried out. Mannitol (2 g/l) as the sole substrate with amorphous Fe(III) hydroxide at final concentration 10 or 100 mM were added to the mineral medium. The formation of siderite and probable magnetite or a mixture of magnetite and maghemite were observed.

  4. A cluster randomized Hybrid Type III trial testing an implementation support strategy to facilitate the use of an evidence-based practice in VA homeless programs.

    Science.gov (United States)

    Smelson, David A; Chinman, Matthew; McCarthy, Sharon; Hannah, Gordon; Sawh, Leon; Glickman, Mark

    2015-05-28

    The Housing and Urban Development-Veterans Affairs Supportive Housing (HUD-VASH) program is one of the largest initiatives to end Veteran homelessness. However, mental health and substance use disorders continue to reduce client stability and impede program success. HUD-VASH programs do not consistently employ evidence-based practices that address co-occurring mental health and substance use disorders. This paper presents a study protocol to evaluate the implementation of an evidence-based, co-occurring disorder treatment called Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking-Veterans Edition (MISSION-Vet) in HUD-VASH using an implementation strategy called Getting To Outcomes (GTO). In three large VA Medical Centers, this Hybrid Type III trial will randomize case managers and their clients by HUD-VASH sub-teams to receive either MISSION-Vet Implementation as Usual (IU-standard training and access to the MISSION-Vet treatment manuals) or MISSION-Vet implementation augmented by GTO. In addition to testing GTO, effectiveness of the treatment (MISSION-Vet) will be assessed using existing Veteran-level data from the HUD-VASH data monitoring system. This project will compare GTO and IU case managers and their clients on the following variables: (1) fidelity to the MISSION-Vet intervention; (2) proportion of time the Veteran is housed; (3) mental health, substance use, and functional outcomes among Veterans; and (4) factors key to the successful deployment of a new treatment as specified by the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) model. This project is an important step for developing an implementation strategy to increase adoption of evidence-based practice use in VA homeless programs, and to further examine efficacy of MISSION-Vet in HUD-VASH. This project has important implications for program managers, policy makers, and researchers within the homelessness field. VA Central IRB approval

  5. Harmonic focus in total thyroidectomy plus level III-IV and VI dissection: a prospective randomized study

    Directory of Open Access Journals (Sweden)

    He Qingqing

    2011-10-01

    Full Text Available Abstract The aim of this study was to compare operating time, postoperative outcomes, and surgical complications of total thyroidectomy plus level III-IV and VI dissection between the no-tie technique using the Harmonic Focus and classic suture ligation for hemostasis. Fifty-four patients underwent total thyroidectomy plus level III-IV and VI dissection by classic suture ligation and 51 patients by the Harmonic Focus. There was obvious distinction as to the operating time between the Focus and classic group (102.8 and 150.1 minutes, respectively, P P P > 0 .05. No patient experienced nerve injury or permanent hypocalcemia. The use of Harmonic Focus for the control of thyroid vessels during thyroid surgery is reliable and safe. The device can offer extraordinary capabilities for delicate tissue grasping and dissection.

  6. Voltammetric Study of Arsenic (III and Arsenic (V in Ground Water of Hajigonj and Kalkini in Bangladesh

    Directory of Open Access Journals (Sweden)

    Mohammad Arifur Rahman

    2008-06-01

    Full Text Available The speciation of arsenic in groundwater samples using Square Wave Anodic Stripping Voltammetry (SWASV, Differential Pulse Anodic Stripping Voltammetry (DPASV and Normal Pulse Anodic Stripping Voltammetry (NPASV are described. Good resolution of the species, arsenic (III and arsenic (V is achieved using SWASV. The reliability of the methods was checked by analyzing the total arsenic content of the samples by Hydride Generation Atomic Absorptioion Spectrophotometer and by analyzing prepared controlled laboratory standard solution. Since this technique is comparatively cheaper than other available techniques it could be a better analytical technique for arsenic speciation from water. In this study, the assessment of inorganic arsenic species in ground water of Kalkini (Madaripur and Hajigonj (Chandpur is reported. It shows that arsenic content in water in different locations is irregular. Most of the locations contain higher level of As(III than As(V. The highest concentration of arsenic is found in Anayetnagor (554.46 ± 0.07 mg/L of Kalkini and Raichar (562 ± 0.50 mg/L of Hajigonj. However, the level of total arsenic and As(III of most of the villages of the study areas are more than the WHO guideline value (50mg/L. Therefore a proper monitoring process should be evolved along with the development of methods to keep the water free from arsenic.

  7. Electrochemical Studies of the Inhibition and Activation Effects of Al (III on the Activity of Bovine Liver Glutamate Dehydrogenase

    Directory of Open Access Journals (Sweden)

    Shuping Bi

    2005-04-01

    Full Text Available Since the study of Al3+ ion on the enzyme activity by using of electrochemical techniques was rarely found in available literatures, the differential-pulse polarography (DPP technique was applied to study the effects of Al3+ ion on the glutamate dehydrogenase (GDH activity in the catalytical reaction of α-KG +NADH+NH4 + ⇔ L-Glu+NAD++H2O by monitoring the DPP reduction current of NAD+. At the plant and animal physiologically relevant pH values (pH=6.5 and 7.5, the GDH enzyme activities were strongly depended on the concentrations of the metal ion in the assay mixture solutions. In the lower Al (III concentration solutions (80μM, the inhibition effects of Al (III were shown again. The cyclic voltammetry of NAD+ and NAD+-GDH in the presence of Al (III can help to explain some biological phenomena. According to the differential-pulse polarography and cyclic voltammetry experiments, the present research confirmed that the electrochemical technique is a convenient and reliable sensor for accurate determination of enzyme activity in biological and environmental samples.

  8. Impact of stage III-IV endometriosis on recipients of sibling oocytes: matched case-control study.

    Science.gov (United States)

    Díaz, I; Navarro, J; Blasco, L; Simón, C; Pellicer, A; Remohí, J

    2000-07-01

    To evaluate the impact of severe endometriosis on IVF-ET outcome in women receiving oocytes from the-same donor. A matched case-control study. Oocyte donation program at the Instituto Valenciano de Infertilidad. Fifty-eight recipients were included in a matched case-control study of IVF-ET in our oocyte donation program. Twenty-five patients were diagnosed by laparoscopy with stage III-IV endometriosis (group I), while the remaining 33 were free of the disease (group II). On the day of retrieval, oocytes from a single donor were donated to recipients from both groups. Some of the donors supplied oocytes for more than 2 patients. Recipients received steroid replacement therapy for endometrial preparation. Ovarian stimulation and oocyte retrieval in donors. Uterine embryo transfer (ET) in recipients after appropriate exogenous hormone replacement therapy (HRT). Pregnancy, implantation, miscarriage, and live birth rates. The number of oocytes donated and fertilized, as well as the number of available and transferred embryos, was not statistically different between the two groups. Pregnancy, implantation, and miscarriage rates were not affected by stage III-IV endometriosis when compared with the control group. The live birth rate was 28.0% in the group with endometriosis and 27.2% in the control group. These results show that implantation is not affected by stage III-IV endometriosis. Given the contemporary methods of endometrial preparation for transfer of embryos derived from donor oocytes, any potential negative effect of severe endometriosis on the uterine environment is undetectable.

  9. Diffusion Kurtosis Imaging of Gliomas Grades II and III - A Study of Perilesional Tumor Infiltration, Tumor Grades and Subtypes at Clinical Presentation.

    Science.gov (United States)

    Delgado, Anna F; Fahlström, Markus; Nilsson, Markus; Berntsson, Shala G; Zetterling, Maria; Libard, Sylwia; Alafuzoff, Irina; van Westen, Danielle; Lätt, Jimmy; Smits, Anja; Larsson, Elna-Marie

    2017-06-01

    Diffusion kurtosis imaging (DKI) allows for assessment of diffusion influenced by microcellular structures. We analyzed DKI in suspected low-grade gliomas prior to histopathological diagnosis. The aim was to investigate if diffusion parameters in the perilesional normal-appearing white matter (NAWM) differed from contralesional white matter, and to investigate differences between glioma malignancy grades II and III and glioma subtypes (astrocytomas and oligodendrogliomas). Forty-eight patients with suspected low-grade glioma were prospectively recruited to this institutional review board-approved study and investigated with preoperative DKI at 3T after written informed consent. Patients with histologically proven glioma grades II or III were further analyzed (n=35). Regions of interest (ROIs) were delineated on T2FLAIR images and co-registered to diffusion MRI parameter maps. Mean DKI data were compared between perilesional and contralesional NAWM (student's t-test for dependent samples, Wilcoxon matched pairs test). Histogram DKI data were compared between glioma types and glioma grades (multiple comparisons of mean ranks for all groups). The discriminating potential for DKI in assessing glioma type and grade was assessed with receiver operating characteristics (ROC) curves. There were significant differences in all mean DKI variables between perilesional and contralesional NAWM (p=grades II (n=23) and III (n=12) (p=0.003-0.048) and 10 variables differed significantly between ACs (n=18) and ODs (n=17) (p=0.011-0.050). ROC curves of the best discriminating variables had an area under the curve (AUC) of 0.657-0.815. Mean DKI variables in perilesional NAWM differ significantly from contralesional NAWM, suggesting altered microstructure by tumor infiltration not depicted on morphological MRI. Histogram analysis of DKI data identifies differences between glioma grades and subtypes.

  10. X-ray Absorption Spectroscopic Studies of High-Spin Nonheme (Alkylperoxo)iron(III) Intermediates

    Energy Technology Data Exchange (ETDEWEB)

    Shan,X.; Rohde, J.; Koehntop, K.; Zhou, Y.; Bukowski, M.; Costas, M.; Fujisawa, K.; Que, Jr., L.

    2007-01-01

    The reactions of iron(II) complexes [Fe(Tpt-Bu,i-Pr)(OH)] (1a, Tpt-Bu,i-Pr = hydrotris(3-tert-butyl-5-isopropyl-1-pyrazolyl)borate), [Fe(6-Me2BPMCN)(OTf)2] (1b, 6-Me2BPMCN = N,N'-bis((2-methylpyridin-6-yl)methyl)-N,N'-dimethyl-trans-1,2-diaminocyclohexane), and [Fe(L8Py2)(OTf)](OTf) (1c, L8Py2 = 1,5-bis(pyridin-2-ylmethyl)-1,5-diazacyclooctane) with tert-BuOOH give rise to high-spin FeIII-OOR complexes. X-ray absorption spectra (XAS) of these high-spin species show characteristic features, distinct from those of low-spin Fe-OOR complexes. These include (1) an intense 1s {yields} 3d preedge feature, with an area around 20 units, (2) an edge energy, ranging from 7122 to 7126 eV, that is affected by the coordination environment, and (3) a 1.86-1.96 Angstroms Fe-OOR bond, compared to the 1.78 Angstroms Fe-OOR bond in low-spin complexes. These unique features likely arise from a flexible first coordination sphere in those complexes. The difference in Fe-OOR bond length may rationalize differences in reactivity between low-spin and high-spin FeIII-OOR species.

  11. Electrical perceptual threshold testing: a validation study.

    Science.gov (United States)

    Leong, Grace W S; Gorrie, Catherine A; Ng, Karl; Rutkowski, Sue; Waite, Phil M E

    2009-01-01

    To investigate inter-rater and intra-rater reliability of electrical perceptual threshold (EPT) testing in assessing somatosensory function in healthy volunteers. Prospective experimental. Hospital-based spinal cord injuries unit. Cutaneous electrical stimulation of 4 dermatomes at ASIA sensory key points (C3, T1, L3, and S2) was performed on 40 control subjects. The lowest ascending stimulus intensity at which sensation was perceived was recorded as the EPT. Mean EPT values for each dermatome, as determined by 2 testers at 2 time points, were examined and plotted against a normative template. Differences and associations between intra- and inter-rater measurements and left-right measurements were studied. EPT results for 2 people with spinal cord injuries were also examined. EPT measurements from left and right sides, obtained from the 2 time points and 2 testers, were found to be strongly associated, with the exception of left and right side measurements at the S2 dermatome. No significant differences in the mean EPT for tester or time period were found. The intra- and inter-rater reliability was good for all dermatomes tested. Mean EPT measurements fell within the range of a normative template at each of the 4 dermatomes tested. EPT is an objective, reproducible, and quantifiable method of assessing sensation in a control group. However, caution should be applied in certain dermatomes such as S2, where there was large variation between left and right side measurements.

  12. Phase I/II Study of Radiofrequency Ablation for Malignant Renal Tumors: Japan Interventional Radiology in Oncology Study Group 0701

    Energy Technology Data Exchange (ETDEWEB)

    Mimura, Hidefumi, E-mail: mimura@marianna-u.ac.jp [St. Marianna University School of Medicine, Department of Radiology (Japan); Arai, Yasuaki, E-mail: arai-y3111@mvh.biglobe.ne.jp [National Cancer Center Hospital, Department of Diagnostic Radiology (Japan); Yamakado, Koichiro, E-mail: yama@clin.medic.mie-u.ac.jp [Mie University School of Medicine, Department of Interventional Radiology (Japan); Sone, Miyuki, E-mail: msone@me.com; Takeuchi, Yoshito, E-mail: yotake62@qg8.so-net.ne.jp [National Cancer Center Hospital, Department of Diagnostic Radiology (Japan); Miki, Tsuneharu, E-mail: tmiki@koto.kpu-m.ac.jp [Kyoto Prefectural University of Medicine, Department of Urology (Japan); Gobara, Hideo, E-mail: gobara@cc.okayama-u.ac.jp [Okayama University Medical School, Department of Radiology (Japan); Sakuhara, Yusuke, E-mail: yusaku@med.hokudai.ac.jp [Hokkaido University School of Medicine, Department of Diagnostic and Interventional Radiology (Japan); Yamamoto, Takanobu, E-mail: tyamamot@tcc.pref.tochigi.lg.jp [Tochigi Cancer Center, Department of Radiology (Japan); Sato, Yozo, E-mail: ysato@aichi-cc.jp [Aichi Cancer Center Hospital, Department of Diagnostic and Interventional Radiology (Japan); Kanazawa, Susumu, E-mail: susumu@cc.okayama-u.ac.jp [Okayama University Medical School, Department of Radiology (Japan)

    2016-05-15

    PurposeThis multicenter phase I/II study evaluated the safety, feasibility, and initial efficacy of radiofrequency ablation (RFA) for small malignant renal tumors.MethodsThirty-three patients were enrolled in the study. A single session of RFA was performed in patients with a renal tumor of 1–3 cm in greatest diameter, with the exception of lesions adjacent to the renal hilum. The primary endpoint was the safety of renal RFA, and the secondary endpoints were its feasibility and initial efficacy for local control, as well as the incidence and grade of adverse events. Clinical efficacy was evaluated by CT scans within 1 week and at a further 4 weeks after the procedure using the criteria adapted from the Response Evaluation Criteria in Solid Tumors.ResultsThe RFA procedure was completed in 100 % (95 % confidence interval [CI] 89–100 %) of all 33 patients. There were no severe adverse events (0 % [95 % CI 0–11 %]). Among the 33 patients, a complete response, partial response, progressive disease, and stable disease were seen in 28 (85 %), 0 (0 %), one (3 %), and one (3 %) patient(s), respectively, with a tumor response rate of 85 % [95 % CI 68–95 %]). Three patients (9 %), including one ineligible patient (3 %), were not evaluable. Out of 30 evaluable patients, a complete response was achieved in 28 (93 %).ConclusionThe current multicenter trial revealed that RFA is a safe, feasible, and effective treatment for small malignant renal tumors in patients who are not candidates for surgery.

  13. Liquid–liquid anion exchange extraction studies of samarium(III from salicylate media using high molecular weight amine

    Directory of Open Access Journals (Sweden)

    Aniruddha M. Mandhare

    2015-07-01

    Full Text Available Liquid–liquid extraction and separation of samarium(III were carried out by using 0.025 mol dm−3 2-octylaminopyridine(2-OAP in xylene at 298 K. The extraction behavior of samarium was studied as a function of pH, weak acid concentration, extractant concentration, diluent, and equilibration time. Samarium was quantitatively extracted at pH 7.5 to 10.0 from 0.01 mol dm−3 sodium salicylate solution with 0.025 mol dm−3 2-OAP. The possible composition of the extracted species in organic phase has been determined by using model of slope analysis method and extraction mechanism was found to proceed via an anion exchange mechanism. The stripping efficiency was found to be quantitative in HNO3, HCl and CH3COOH. The robustness of the procedure was demonstrated by the average recoveries obtained (>99.6% for samarium(III extraction in the presence of several cations and anions which are commonly associated with it. The proposed method facilitates the separation and determination of samarium(III from binary and synthetic mixtures. The various thermodynamic functions like free energy (ΔG, enthalpy (ΔH and entropy (ΔS of extraction mechanism were discussed.

  14. High-field CW electron paramagnetic resonance spectroscopy with Gd(III) tags for structure-dynamics studies of proteorhodopsin

    Science.gov (United States)

    Clayton, Jessica A.; Han, Chung-Ta; Wilson, C. Blake; Qi, Mian; Godt, Adelheid; Goldfarb, Daniella; Sherwin, Mark S.; Han, Songi

    Proteorhodopsin (PR) is a seven-helical transmembrane protein that functions as a light-activated proton pump. Much of the structure of PR has been mapped by solution-state NMR and X-ray crystallography, however it remains difficult to study protein associations and conformational changes. Here we report development of 240 GHz CW electron paramagnetic resonance (EPR) as a tool to determine inter- and intra-protein distances in the range of 1-4 nm under biologically relevant conditions, using S = 7/2 Gd(III)-based complexes as an EPR-active paramagnetic tag. The dipolar coupling between Gd(III) pairs is determined via the width of the central transition in the CW EPR spectrum, allowing for the inference of an interspin distance. Proof-of-principle experiments are demonstrated on Gd-ruler molecules, from cryogenic temperatures up to room temperature. First results applying this method to inter-protein measurement of Gd(III) tagged PR oligomers reveals distances consistent with the penta- or hexameric organization determined by crystal structure. Finally, we present progress towards development of measurement methods that will enable observation of light-induced conformational changes in the EF-loop region of PR at temperatures above the protein dynamical transition. This work is supported by NSF MCB-1617025 and NSF MCB-1244651.

  15. Fundamental Studies and Development of III-N Visible LEDs for High-Power Solid-State Lighting Applications

    Energy Technology Data Exchange (ETDEWEB)

    Dupuis, Russell

    2012-02-29

    The goal of this program is to understand in a fundamental way the impact of strain, defects, polarization, and Stokes loss in relation to unique device structures upon the internal quantum efficiency (IQE) and efficiency droop (ED) of III-nitride (III-N) light-emitting diodes (LEDs) and to employ this understanding in the design and growth of high-efficiency LEDs capable of highly-reliable, high-current, high-power operation. This knowledge will be the basis for our advanced device epitaxial designs that lead to improved device performance. The primary approach we will employ is to exploit new scientific and engineering knowledge generated through the application of a set of unique advanced growth and characterization tools to develop new concepts in strain-, polarization-, and carrier dynamics-engineered and low-defect materials and device designs having reduced dislocations and improved carrier collection followed by efficient photon generation. We studied the effects of crystalline defect, polarizations, hole transport, electron-spillover, electron blocking layer, underlying layer below the multiplequantum- well active region, and developed high-efficiency and efficiency-droop-mitigated blue LEDs with a new LED epitaxial structures. We believe new LEDs developed in this program will make a breakthrough in the development of high-efficiency high-power visible III-N LEDs from violet to green spectral region.

  16. Bone thickness of the infrazygomatic crest area in skeletal Class III growing patients: A computed tomographic study

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyub Soo; Choi, Hang Moon; Choi, Dong Soon; Jang, Insan; Cha, Bong Kuen [College of Dentistry and Research Institute of Oral Science, Gangneung-Wonju National University, Gangneung (Korea, Republic of)

    2013-12-15

    This study was performed to investigate the bone thickness of the infrazygomatic crest area by computed tomography (CT) for placement of a miniplate as skeletal anchorage for maxillary protraction in skeletal Class III children. CT images of skeletal Class III children (7 boys, 9 girls, mean age: 11.4 years) were taken parallel to the Frankfurt horizontal plane. The bone thickness of the infrazygomatic crest area was measured at 35 locations on the right and left sides, perpendicular to the bone surface. The bone was thickest (5.0 mm) in the upper zygomatic bone and thinnest (1.1 mm) in the anterior wall of the maxillary sinus. Generally, there was a tendency for the bone to be thicker at the superior and lateral area of the zygomatic process of the maxilla. There was no clinically significant difference in bone thickness between the right and left sides; however, it was thicker in male than in female subjects. In the infrazygomatic crest area, the superior and lateral area of the zygomatic process of the maxilla had the most appropriate thickness for placement of a miniplate in growing skeletal Class III children with a retruded maxilla.

  17. Study of the effectiveness of polyamide reverse osmosis membranes in the recovery of Cr(III) in tanning. Estudio sobre la efectividad de las membranas de osmosis inversa de poliamida en la recuperacion de Cr(III) en curticion

    Energy Technology Data Exchange (ETDEWEB)

    Galan, M.; Gonzalez, C.; Llorens, J.; Mans, C. (Barcelona Univ., Tarragona (Spain). Dept. d' Enginyeria Quimica i Bioqumica)

    1992-12-01

    Laboratory experiments on reverse osmosis using water containing Cr2(SO4)3 and a Film Tech Corporation TW30-2514 membrane are described. The type of cell employed allowed the membrane's rejection of Cr(III) to be measured with a high degree of accuracy. Tests were carried out varying the Cr concentration, the pressure and the temperature. The results obtained have implications regarding the suitability of reverse osmosis in recovering Cr from tanning waste water. (Author)

  18. Advanced Demonstration and Test Reactor Options Study

    Energy Technology Data Exchange (ETDEWEB)

    Petti, David Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hill, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Gehin, J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gougar, Hans David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Strydom, Gerhard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Heidet, F. [Argonne National Lab. (ANL), Argonne, IL (United States); Kinsey, J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Grandy, Christopher [Argonne National Lab. (ANL), Argonne, IL (United States); Qualls, A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Brown, Nicholas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Powers, J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hoffman, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Croson, D. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    Global efforts to address climate change will require large-scale decarbonization of energy production in the United States and elsewhere. Nuclear power already provides 20% of electricity production in the United States (U.S.) and is increasing in countries undergoing rapid growth around the world. Because reliable, grid-stabilizing, low emission electricity generation, energy security, and energy resource diversity will be increasingly valued, nuclear power’s share of electricity production has a potential to grow. In addition, there are non electricity applications (e.g., process heat, desalination, hydrogen production) that could be better served by advanced nuclear systems. Thus, the timely development, demonstration, and commercialization of advanced nuclear reactors could diversify the nuclear technologies available and offer attractive technology options to expand the impact of nuclear energy for electricity generation and non-electricity missions. The purpose of this planning study is to provide transparent and defensible technology options for a test and/or demonstration reactor(s) to be built to support public policy, innovation and long term commercialization within the context of the Department of Energy’s (DOE’s) broader commitment to pursuing an “all of the above” clean energy strategy and associated time lines. This planning study includes identification of the key features and timing needed for advanced test or demonstration reactors to support research, development, and technology demonstration leading to the commercialization of power plants built upon these advanced reactor platforms. This planning study is consistent with the Congressional language contained within the fiscal year 2015 appropriation that directed the DOE to conduct a planning study to evaluate “advanced reactor technology options, capabilities, and requirements within the context of national needs and public policy to support innovation in nuclear energy

  19. Theoretical analysis of the binding of iron(III) protoporphyrin IX to 4-methoxyacetophenone thiosemicarbazone via DFT-D3, MEP, QTAIM, NCI, ELF, and LOL studies.

    Science.gov (United States)

    Nkungli, Nyiang Kennet; Ghogomu, Julius Numbonui

    2017-07-01

    Thiosemicarbazones display diverse pharmacological properties, including antimalarial activities. Their pharmacological activities have been studied in depth, but little of this research has focused on their antimalarial mode of action. To elucidate this antimalarial mechanism, we investigated the nature of the interactions between iron(III) protoporphyrin IX (Fe(III)PPIX) and the thione-thiol tautomers of 4-methoxyacetophenone thiosemicarbazone (MAPTSC). Dispersion-corrected density functional theory (DFT-D3), the quantum theory of atoms in molecules (QTAIM), the noncovalent interaction (NCI) index, the electron localization function (ELF), the localized orbital locator (LOL), and thermodynamic calculations were employed in this work. Fe(III)PPIX-MAPTSC binding is expected to inhibit hemozoin formation, thereby preventing Fe(III)PPIX detoxification in plasmodia. Preliminary studies geared toward the identification of atomic binding sites in the thione-thiol tautomers of MAPTSC were carried out using molecular electrostatic potential (MEP) maps and conceptual DFT-based local reactivity indices. The thionic sulfur and the 2 N-azomethine nitrogen/thiol sulfur of, respectively, the thione and thiol tautomers of MAPTSC were identified as the most favorable nucleophilic sites for electrophilic attack. The negative values of the computed Fe(III)PPIX-MAPTSC binding energies, enthalpies, and Gibbs free energies are indicative of the existence and stability of Fe(III)PPIX-MAPTSC complexes. MAPTSC-Fe(III) coordinate bonds and strong hydrogen bonds (N-H···O) between the NH 2 group in MAPTSC and the C=O group in one propionate side chain of Fe(III)PPIX are crucial to Fe(III)PPIX-MAPTSC binding. QTAIM, NCI, ELF, and LOL analyses revealed a subtle interplay of weak noncovalent interactions dominated by dispersive-like van der Waals interactions between Fe(III)PPIX and MAPTSC that stabilize the Fe(III)PPIX-MAPTSC complexes.

  20. Richard III

    DEFF Research Database (Denmark)

    Lauridsen, Palle Schantz

    2017-01-01

    Kort analyse af Shakespeares Richard III med fokus på, hvordan denne skurk fremstilles, så tilskuere (og læsere) langt henad vejen kan føle sympati med ham. Med paralleller til Netflix-serien "House of Cards"......Kort analyse af Shakespeares Richard III med fokus på, hvordan denne skurk fremstilles, så tilskuere (og læsere) langt henad vejen kan føle sympati med ham. Med paralleller til Netflix-serien "House of Cards"...

  1. The UVES Large Program for testing fundamental physics - III. Constraints on the fine-structure constant from three telescopes

    Science.gov (United States)

    Evans, T. M.; Murphy, M. T.; Whitmore, J. B.; Misawa, T.; Centurion, M.; D'Odorico, S.; Lopez, S.; Martins, C. J. A. P.; Molaro, P.; Petitjean, P.; Rahmani, H.; Srianand, R.; Wendt, M.

    2014-11-01

    Large statistical samples of quasar spectra have previously indicated possible cosmological variations in the fine-structure constant, α. A smaller sample of higher signal-to-noise ratio spectra, with dedicated calibration, would allow a detailed test of this evidence. Towards that end, we observed equatorial quasar HS 1549+1919 with three telescopes: the Very Large Telescope, Keck and, for the first time in such analyses, Subaru. By directly comparing these spectra to each other, and by `supercalibrating' them using asteroid and iodine-cell tests, we detected and removed long-range distortions of the quasar spectra's wavelength scales which would have caused significant systematic errors in our α measurements. For each telescope we measure the relative deviation in α from the current laboratory value, Δα/α, in three absorption systems at redshifts zabs = 1.143, 1.342 and 1.802. The nine measurements of Δα/α are all consistent with zero at the 2σ level, with 1σ statistical (systematic) uncertainties 5.6-24 (1.8-7.0) parts per million (ppm). They are also consistent with each other at the 1σ level, allowing us to form a combined value for each telescope and, finally, a single value for this line of sight: Δα/α = -5.4 ± 3.3stat ± 1.5sys ppm, consistent with both zero and previous, large samples. We also average all Large Programme results measuring Δα/α = -0.6 ± 1.9stat ± 0.9sys ppm. Our results demonstrate the robustness and reliability at the 3 ppm level afforded by supercalibration techniques and direct comparison of spectra from different telescopes.

  2. Engineering study: Fast Flux Test Facility fuel reprocessing

    Energy Technology Data Exchange (ETDEWEB)

    Beary, M.M.; Raab, G.J.; Reynolds, W.R. Jr.; Yoder, R.A.

    1974-01-07

    Several alternatives were studied for reprocessing FFTF fuels at Hanford. Alternative I would be to decontaminate and trim the fuel at T Plant and electrolytically dissolve the fuel at Purex. Alternative II would be to decontaminate and shear leach the fuels in a new facility near Purex. Alternative III would be to decontaminate and store fuel elements indefinitely at T Plant for subsequent offsite shipment. Alternative I, 8 to 10 M$ and 13 quarter-years; for Alternative II, 24 to 28 M$ and 20 quarter-years; for Alternative III, 3 to 4 M$ and 8 quarter-years. Unless there is considerable slippage in the FFTF shipping schedule, it would not be possible to build a new facility as described in Alternative II in time without building temporary storage facilities at T Plant, as described in Alternative III. (auth)

  3. FETAX interlaboratory validation study: Phase 2 testing

    Energy Technology Data Exchange (ETDEWEB)

    Bantle, J.A. (Oklahoma State Univ., Stillwater, OK (United States). Dept. of Zoology); Burton, D.T. (WYE Research and Educational Center, Queenstown, MD (United States)); Dawson, D.A. (Ashland Univ., OH (United States). Dept. of Biology and Toxicology) (and others)

    1994-10-01

    The Frog Embryo Teratogenesis Assay-Xenopus (FETAX) is a 96-h whole embryo developmental toxicity screening assay that can be used in ecotoxicology and in detecting mammalian developmental toxicants when an in vitro metabolic activation system is employed. A standardized American Society for Testing and Materials (ASTM) guide for the conduct of FETAX has been published along with a companion atlas that helps in embryo staging and identifying malformations. As part of the ASTM process, an interlaboratory validation study was undertaken to evaluate the repeatability and reliability of FETAX. Six different laboratories participated in the study. Each laboratory utilized one technician with the exception of one laboratory, which utilized two independent technicians. In Phase 1, FETAX proved to be more repeatable and reliable than many other bioassays. However, some excessive variation was observed in a few laboratories. Some of this variation may have been due to an initial lack of experience with the assay by some technicians. Phase 2, which is reported here, showed far less intralaboratory and interlaboratory variability than did Phase 1. Nonteratogens such as saccharin and sodium cyclamate showed the most consistent results, whereas more variability was observed for the teratogens caffeine and 5-fluorouracil. Interlaboratory coefficient of variation values for all FETAX end points ranged from 7.3 to 54.7%. The minimum concentration to inhibit growth proved to be the most variable end point for three of the four test chemicals, whereas the LC50 and EC50 (malformation) proved to be less variable.

  4. Synthesis, characterization, crystal structure and electrochemical studies of ionic iron(III) dipicolinato complex

    Science.gov (United States)

    Ghasemi, Fatemeh; Ghasemi, Khaled; Rezvani, Ali Reza; Rosli, Mohd Mustaqim; Razak, Ibrahim Abdul

    2017-09-01

    The new complex (NH4)[Fe(dipic)2] (1) (dipicH2 = 2,6-pyridinedicarboxylic acid), was synthesized and characterized by elemental analysis, FTIR and UV-Vis spectroscopy and single crystal X-ray method. The crystal system is tetragonal with space group I41/a. The FeIII ion and the N atom of the ammonium cation are located on a crystallographic fourfold rotoinversion axis (4 bar). The Nsbnd H⋯O and Csbnd H⋯O intermolecular hydrogen bonding and π⋯π stacking interactions play an important role in the formation of a 3-dimensional anion-cation network and stabilization of the crystal structure. The redox behavior of the complex was also investigated by cyclic voltammetry.

  5. X-Ray Absorption Spectroscopic Studies of High-Spin Nonheme (Alkylperoxo)Iron(III) Intermediates

    Energy Technology Data Exchange (ETDEWEB)

    Shan, X.; Rohde, J.-U.; Koehntop, K.D.; Zhou, Y.; Bukowski, M.R.; Costas, M.; Fujisawa, K.; Que, L.; Jr.

    2009-06-04

    The reactions of iron(II) complexes [Fe(Tp{sup t-Bu,i-Pr})(OH)] (1a, Tp{sup t-Bu,i-Pr} = hydrotris(3-tert-butyl-5-isopropyl-1-pyrazolyl)borate), [Fe(6-Me{sub 2}BPMCN)(OTf){sub 2}] (1b, 6-Me{sub 2}BPMCN = N,N'-bis((2-methylpyridin-6-yl)methyl)-N,N'-dimethyl-trans-1,2-diaminocyclohexane), and [Fe(L{sup 8}Py{sub 2})(OTf)](OTf) (1c, L{sup 8}Py{sub 2} = 1,5-bis(pyridin-2-ylmethyl)-1,5-diazacyclooctane) with tert-BuOOH give rise to high-spin Fe{sup III}-OOR complexes. X-ray absorption spectra (XAS) of these high-spin species show characteristic features, distinct from those of low-spin Fe-OOR complexes (Rohde, J.-U.; et al. J. Am. Chem. Soc. 2004, 126, 16750--16761). These include (1) an intense 1s {yields} 3d preedge feature, with an area around 20 units, (2) an edge energy, ranging from 7122 to 7126 eV, that is affected by the coordination environment, and (3) a 1.86--1.96 {angstrom} Fe-OOR bond, compared to the 1.78 {angstrom} Fe-OOR bond in low-spin complexes. These unique features likely arise from a flexible first coordination sphere in those complexes. The difference in Fe-OOR bond length may rationalize differences in reactivity between low-spin and high-spin Fe{sup III}-OOR species.

  6. Evaluation of precipitates used in strainer head loss testing: Part III. Long-term aluminum hydroxide precipitation tests in borated water

    Energy Technology Data Exchange (ETDEWEB)

    Bahn, Chi Bum, E-mail: bahn@anl.go [Argonne National Laboratory, Lemont, IL 60439 (United States); Kasza, Ken E.; Shack, William J.; Natesan, Ken [Argonne National Laboratory, Lemont, IL 60439 (United States); Klein, Paul [United States Nuclear Regulatory Commission, Rockville, MD 20852 (United States)

    2011-05-15

    Research highlights: Aluminum hydroxide precipitation boundary is similar to that for amorphous phase. Various precipitation tests are combined into one map in temperature-'pH + p[Al]{sub T}'. Flocculation tendency of precipitates depend on pH and total Al concentration. DLVO theory explains qualitatively the dependency of flocculation tendency on pH. - Abstract: Long-term aluminum (Al) hydroxide precipitation tests were conducted in slightly alkaline solutions containing 2500 ppm boron. The solution temperature was cycled to obtain a temperature history more representative of emergency core cooling system temperatures after a loss-of-coolant accident. The observed Al precipitation boundary was close to predicted results for amorphous precipitates, which are higher than the solubility expected for crystalline forms. Bench-scale and loop head loss test results under various conditions were successfully combined into single map in a temperature - 'pH + p[Al]{sub T}' domain, which yielded two bounding lines for Al hydroxide solubility in borated alkaline water that depend on whether or not loop head loss tests with Al alloy coupons are included. Precipitates were observed to form either as fine, cloudy suspensions, which showed very little tendency to settle, or as flocculated precipitates. The flocculation tendency of the precipitates can be qualitatively explained by a colloid stability theory or a phase diagram for protein solutions.

  7. Ten Year Operating Test Results and Post-Test Analysis of a 1/10 Segment Stirling Sodium Heat Pipe, Phase III

    Science.gov (United States)

    Rosenfeld, John, H; Minnerly, Kenneth, G; Dyson, Christopher, M.

    2012-01-01

    High-temperature heat pipes are being evaluated for use in energy conversion applications such as fuel cells, gas turbine re-combustors, Stirling cycle heat sources; and with the resurgence of space nuclear power both as reactor heat removal elements and as radiator elements. Long operating life and reliable performance are critical requirements for these applications. Accordingly, long-term materials compatibility is being evaluated through the use of high-temperature life test heat pipes. Thermacore, Inc., has carried out a sodium heat pipe 10-year life test to establish long-term operating reliability. Sodium heat pipes have demonstrated favorable materials compatibility and heat transport characteristics at high operating temperatures in air over long time periods. A representative one-tenth segment Stirling Space Power Converter heat pipe with an Inconel 718 envelope and a stainless steel screen wick has operated for over 87,000 hr (10 yr) at nearly 700 C. These life test results have demonstrated the potential for high-temperature heat pipes to serve as reliable energy conversion system components for power applications that require long operating lifetime with high reliability. Detailed design specifications, operating history, and post-test analysis of the heat pipe and sodium working fluid are described.

  8. DECOVALEX III PROJECT. Thermal-Chemical Modeling of the Yucca Mountain Project Drift Scale Test. Task 2D Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Datta, Robin N. [Bechtel SAlC Company, Las Vegas (US)] (comp.)

    2005-02-15

    Task 2D concerns numerical simulation of the coupled THC modeling of the DST test at Yucca mountain, with given results for geologic, thermal, hydrologic, mineralogic and petrologic characterization, as-built configuration of the test block of DST, including locations of various sensors and measuring instruments and the plans for heating and cooling, including expected heater powers at various times, and compared with geochemical measurements performed on gas, water, and mineral samples collected from the DST. Two teams of DOE/LBNL (USA) and JNC (Japan) participated the task with different approaches. The LBNL model represented the fractures and rock matrix by a dual-continuum concept, with the mineral-water-gas reactions treated by primarily kinetic and a few equilibrium reactions. The JNC model represented the fractures and matrix as a single effective continuum, with equilibrium mineral-water reactions controlling the chemical evolution (as well as considering aqueous species transport). The JNC team performed the coupled THC simulation of the Yucca Mountain Drift Scale Test by the coupled THM code 'THAMES', mass transport code 'Dtransu' and geochemical code 'PHREEQE' under coupling system code 'COUPLYS'. The LBNL team simulated the THC processes include coupling between heat, water, and vapor flow; aqueous and gaseous species transport; kinetic and equilibrium mineral-water reactions; and feedback of mineral precipitation/dissolution on porosity, permeability, and capillary pressure, with the FDM code TOUGHREACT V3.0. In general, both models capture the temperature evolution in the rock fairly well, although the JNC model yielded a closer match to the initial temperature rise in the rock, probably due to the better site-specific thermal data. Both models showed the contrasting solubility effects of increasing temperature on calcite and silica solubility; yet the dual continuum approach better represented the effects of

  9. Moessbauer spectroscopic study on valence-detrapping and trapping of mixed-valence trinuclear iron(III, III, II) fluorine-substituted benzoate complexes

    Energy Technology Data Exchange (ETDEWEB)

    Sakai, Yoichi, E-mail: yocsakai@daido-it.ac.jp; Onaka, Satoru [Daido University (Japan); Takahashi, Masashi [Toho University (Japan); Ogiso, Ryo; Takayama, Tsutomu [Daido University (Japan); Nakamoto, Tadahiro [Toray Research Center (Japan)

    2012-03-15

    Four mixed-valence trinuclear iron(III, III, II) fluorine-substituted benzoate complexes were synthesized; Fe{sub 3}O(C{sub 6}F{sub 5}COO){sub 6}(C{sub 5}H{sub 5}N){sub 3}{center_dot}CH{sub 2}Cl{sub 2} (1), Fe{sub 3}O(C{sub 6}F{sub 5}COO){sub 6}(C{sub 5}H{sub 5}N){sub 3} (2), Fe{sub 3}O(2H-C{sub 6}F{sub 4}COO){sub 6}(C{sub 5}H{sub 5}N){sub 3} (3), and Fe{sub 3}O(4H-C{sub 6}F{sub 4}COO){sub 6}(C{sub 5}H{sub 5}N){sub 3} (4), in which valence-detrapping and trapping phenomena have been investigated by {sup 57}Fe- Moessbauer spectroscopy. The valence state of the three iron ions is trapped at lower temperatures while it is fully detrapped at higher temperatures for 1. Valence detrapping is not observed for 2, 3, and 4 even at room temperature, although Moessbauer spectra for 3 and 4 show complicated temperature dependence.

  10. Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III).

    Science.gov (United States)

    Stein, Paul D; Chenevert, Thomas L; Fowler, Sarah E; Goodman, Lawrence R; Gottschalk, Alexander; Hales, Charles A; Hull, Russell D; Jablonski, Kathleen A; Leeper, Kenneth V; Naidich, David P; Sak, Daniel J; Sostman, H Dirk; Tapson, Victor F; Weg, John G; Woodard, Pamela K

    2010-04-06

    The accuracy of gadolinium-enhanced magnetic resonance pulmonary angiography and magnetic resonance venography for diagnosing pulmonary embolism has not been determined conclusively. To investigate performance characteristics of magnetic resonance angiography, with or without magnetic resonance venography, for diagnosing pulmonary embolism. Prospective, multicenter study from 10 April 2006 to 30 September 2008. 7 hospitals and their emergency services. 371 adults with diagnosed or excluded pulmonary embolism. Sensitivity, specificity, and likelihood ratios were measured by comparing independently read magnetic resonance imaging with the reference standard for diagnosing pulmonary embolism. Reference standard diagnosis or exclusion was made by using various tests, including computed tomographic angiography and venography, ventilation-perfusion lung scan, venous ultrasonography, d-dimer assay, and clinical assessment. Magnetic resonance angiography, averaged across centers, was technically inadequate in 25% of patients (92 of 371). The proportion of technically inadequate images ranged from 11% to 52% at various centers. Including patients with technically inadequate images, magnetic resonance angiography identified 57% (59 of 104) with pulmonary embolism. Technically adequate magnetic resonance angiography had a sensitivity of 78% and a specificity of 99%. Technically adequate magnetic resonance angiography and venography had a sensitivity of 92% and a specificity of 96%, but 52% of patients (194 of 370) had technically inadequate results. A high proportion of patients with suspected embolism was not eligible or declined to participate. Magnetic resonance pulmonary angiography should be considered only at centers that routinely perform it well and only for patients for whom standard tests are contraindicated. Magnetic resonance pulmonary angiography and magnetic resonance venography combined have a higher sensitivity than magnetic resonance pulmonary angiography

  11. A spectrophotometric study of aqueous Au(III) halide-hydroxide complexes at 25-80 °C

    Science.gov (United States)

    Usher, Al; McPhail, D. C.; Brugger, Joël

    2009-06-01

    The mobility and transport of gold in low-temperature waters and brines is affected by the aqueous speciation of gold, which is sensitive in particular to pH, oxidation and halide concentrations. In this study, we use UV-Vis spectrophotometry to identify and measure the thermodynamic properties of Au(III) aqueous complexes with chloride, bromide and hydroxide. Au(III) forms stable square planar complexes with hydroxide and halide ligands. Based on systematic changes in the absorption spectra of solutions in three binary systems NaCl-NaBr, NaCl-NaOH and NaBr-NaOH at 25 °C, we derived log dissociation constants for the following mixed and end-member halide and hydroxide complexes: [AuCl 3Br] -, [AuCl 2Br 2] -, [AuBr 3Cl] - and [AuBr 4] -; [AuCl 3(OH)] -, [AuCl 2(OH) 2] -, [AuCl(OH) 3] - and [Au(OH) 4] -; and [AuBr 3(OH)] -, [AuBr 2(OH) 2] - and [AuBr(OH) 3] -. These are the first reported results for the mixed chloride-bromide complexes. Increasing temperature to 80 °C resulted in an increase in the stability of the mixed chloride-bromide complexes, relative to the end-member chloride and bromide complexes. For the [AuCl (4-n)(OH) n] - series of complexes ( n = 0-4), there is an excellent agreement between our spectrophotometric results and previous electrochemical results of Chateau et al. [Chateau et al. (1966)]. In other experiments, the iodide ion (I -) was found to be unstable in the presence of Au(III), oxidizing rapidly to I 2(g) and causing Au to precipitate. Predicted Au(III) speciation indicates that Au(III) chloride-bromide complexes can be important in transporting gold in brines with high bromide-chloride ratios (e.g., >0.05), under oxidizing (atmospheric), acidic (pH hydrometallurgy and medicine.

  12. Evaluation of precipitates used in strainer head loss testing : Part III. Long-term aluminum hydroxide precipitation tests in borated water.

    Energy Technology Data Exchange (ETDEWEB)

    Bahn, C. B.; Kasza, K. E.; Shack, W. J.; Natesan, K.; Klein, P. (Nuclear Engineering Division); (USNRC)

    2011-05-01

    Long-term aluminum (Al) hydroxide precipitation tests were conducted in slightly alkaline solutions containing 2500 ppm boron. The solution temperature was cycled to obtain a temperature history more representative of emergency core cooling system temperatures after a loss-of-coolant accident. The observed Al precipitation boundary was close to predicted results for amorphous precipitates, which are higher than the solubility expected for crystalline forms. Bench-scale and loop head loss test results under various conditions were successfully combined into single map in a temperature - 'pH + p[Al]{sub T}' domain, which yielded two bounding lines for Al hydroxide solubility in borated alkaline water that depend on whether or not loop head loss tests with Al alloy coupons are included. Precipitates were observed to form either as fine, cloudy suspensions, which showed very little tendency to settle, or as flocculated precipitates. The flocculation tendency of the precipitates can be qualitatively explained by a colloid stability theory or a phase diagram for protein solutions.

  13. Increasing Efficiency of Recruitment in Early Parkinson's Disease Trials: A Case Study Examination of the STEADY-PD III Trial.

    Science.gov (United States)

    Berk, Sarah; Greco, Brittany L; Biglan, Kevin; Kopil, Catherine M; Holloway, Robert G; Meunier, Claire; Simuni, Tanya

    2017-01-01

    Challenges in clinical trial recruitment threaten the successful development of improved therapies. This is particularly true in Parkinson's disease (PD) studies of disease modification where the population of interest is difficult to find and study design is more complex. This paper seeks to understand how STEADY PD III, a National Institute of Neurological Disorders and Stroke (NINDS) funded phase 3 trial evaluating the efficacy of isradipine as a disease modifying agent for PD, was able to recruit their full target population 6 months ahead of schedule. STEADY PD III aimed to enroll 336 individuals with early stage idiopathic PD within 18 months using 57 sites across the United States and Canada. The study included a 10% NIH minority recruitment goal. Eligible participants agreed to be followed for up to 36 months, complete 12 in-person visits and 4 telephone visits. A Recruitment Committee of key stakeholders was critical in the development of a comprehensive recruitment strategy involving: multi-modal outreach, protocol modifications and comprehensive site selection and activation. Efforts to increase site-specific minority recruitment strategies were encouraged through additional funding. A total of 336 individuals, including 34 minorities, were enrolled within 12 months - 6 months ahead of the projected timeline. Quantitative analysis of recruitment activity questionnaires found that of the sites that completed them (n = 54), (20.4%) met goals, (24.1%) exceeded goals, and (55.6%) fell below projected goals. Referral sources completed at time of screening indicate top four study referral sources as: site personnel (53.8%); neurologists (24%); Fox Trial Finder (10.2%); and communications from The Michael J. Fox Foundation (3.9%). STEADY PD III serves as an important example of methods that can be used to increase clinical trial recruitment. This research highlights a continued need to improve site infrastructure and dedicate more resources to increased

  14. Atmospheric Test Models and Numerical Experiments for the Simulation of the Global Distributions of Weather Data Transponders III. Horizontal Distributions

    Energy Technology Data Exchange (ETDEWEB)

    Molenkamp, C.R.; Grossman, A.

    1999-12-20

    A network of small balloon-borne transponders which gather very high resolution wind and temperature data for use by modern numerical weather predication models has been proposed to improve the reliability of long-range weather forecasts. The global distribution of an array of such transponders is simulated using LLNL's atmospheric parcel transport model (GRANTOUR) with winds supplied by two different general circulation models. An initial study used winds from CCM3 with a horizontal resolution of about 3 degrees in latitude and longitude, and a second study used winds from NOGAPS with a 0.75 degree horizontal resolution. Results from both simulations show that reasonable global coverage can be attained by releasing balloons from an appropriate set of launch sites.

  15. The macular mapping test: a reliability study

    Directory of Open Access Journals (Sweden)

    Davies Leon N

    2005-08-01

    Full Text Available Abstract Background Age-related macular degeneration (ARMD is the leading cause of visual disability in people over 60 years of age in the developed world. The success of treatment deteriorates with increased latency of diagnosis. The purpose of this study was to determine the reliability of the macular mapping test (MMT, and to investigate its potential as a screening tool. Methods The study population comprised of 31 healthy eyes of 31 participants. To assess reliability, four macular mapping test (MMT measurements were taken in two sessions separated by one hour by two practitioners, with reversal of order in the second session. MMT readings were also taken from 17 age-related maculopathy (ARM, and 12 AMD affected eyes. Results For the normal cohort, average MMT scores ranged from 85.5 to 100.0 MMT points. Scores ranged from 79.0 to 99.0 for the ARM group and from 9.0 to 92.0 for the AMD group. MMT scores were reliable to within ± 7.0 points. The difference between AMD affected eyes and controls (z = 3.761, p = Conclusion The reliability data shows that a change of 14 points or more is required to indicate a clinically significant change. This value is required for use of the MMT as an outcome measure in clinical trials. Although there was no difference between MMT scores from ARM affected eyes and controls, the MMT has the advantage over the Amsler grid in that it uses a letter target, has a peripheral fixation aid, and it provides a numerical score. This score could be beneficial in office and home monitoring of AMD progression, as well as an outcome measure in clinical research.

  16. Assessing child belt fit, volume II : effect of restraint configuration, booster seat designs, seating procedure, and belt fit on the dynamic response of the hybrid III 10-year-old ATD in sled tests.

    Science.gov (United States)

    2008-09-01

    A total of 49 dynamic sled tests were performed with the Hybrid III 10YO to examine issues relating to child belt fit. The goals of these tests were to evaluate ATD response to realistic belt geometries and belt fit, develop methods for accurate, rep...

  17. Nutritional Status Assessment During the Phase IIA and Phase III Lunar/Mars Life Support Test Project

    Science.gov (United States)

    Smith, Scott M.; Block, Gladys; Davis-Street, Janis E.; DeKerlegand, Diane E.; Fanselow, Stephanie A.; Fesperman, J. Vernell; Gillman, Patricia L.; Nillen, Jeannie I.; Rice, Barbara L.; Smith, Myra D.

    2000-01-01

    Nutrition is a critical concern for extended-duration space missions (Smith and Lane, 1999). Loss of body weight is a primary consequence of altered nutrition, and is frequently observed during space flight (Smith and Lane; 1999). Other existing dietary concerns for space flight include excessive intakes of sodium and iron, and insufficient intakes of water and vitamin D (Smith and Lane, 1999). Furthermore, dependence on closed or semi-closed food systems increases the likelihood of inadequate intakes of key nutrients. This is a significant concern for extended-duration space missions. Space nutrition research often necessitates detailed recording of all food consumption. While this yields extremely accurate data, it requires considerable time and effort, and thus is not suitable for routine medical monitoring during space flight. To alleviate this problem, a food frequency questionnaire (FFQ) was designed to provide a quick and easy, yet reasonably accurate, method for crewmembers to provide dietary intake information to the ground. We report here a study which was designed to assess nutritional status before, during, and after the 60-d and 91-d chamber stays. An additional goal of the study was to validate a food frequency questionnaire designed specifically for use with space flight food systems.

  18. Synthesis, characterization, luminescent properties and theoretical study of two new coordination polymers containing lanthanide [Ce(III) or Yb(III)] and succinate ions

    Science.gov (United States)

    de Oliveira, Carlos Alberto F.; da Silva, Fausthon Fred; Malvestiti, Ivani; Malta, Valéria Rodrigues dos S.; Dutra, José Diogo L.; da Costa, Nivan B.; Freire, Ricardo O.; Alves, Severino

    2013-06-01

    Two new three-dimensional coordination polymers [Ce2(C4H4O4)3(H2O)2]nṡH2O 1 and [Yb2(C4H4O4)3(H2O)2]nṡH2O 2 have been synthesized under hydrothermal conditions and characterized by single-crystal X-ray, elemental, infrared and thermogravimetric analysis. Both compounds crystallized in the monoclinic system and space group C2/c with cell parameters a = 20.1178(2), b = 7.98150(10), c = 14.03090(10), β = 120.9050(10), cell volume = 1933.07(3) Å3 for 1, and a = 19.7360(3), b = 7.59790(10), c = 13.7564(2), β = 121.3060(10), cell volume = 1762.47(4) for 2. The solid-state structures of the two metal-organic frameworks (MOFs) were subjected to detailed analysis using the semiempirical Sparkle/AM1, Sparkle/PM3 and Sparkle/PM6 quantum models. The theoretical results obtained were in good overall agreement with the experimental data, although the Sparkle/PM3 model presented the highest accuracy. The luminescent spectra of 1 and 2 showed emission bands characteristic of the Ce (III) and Yb (III) at 444 nm and 970 nm, respectively. Thermal analysis revealed that both MOFs lost one molecule of water of hydration and two molecules of coordinated water upon heating. In compound 1, the removal of water occurred in two steps while in 2, water loss occurred in a single step.

  19. Localization of Electronic States in III-V Semiconductor Alloys: A Comparative Study

    Science.gov (United States)

    Pashartis, C.; Rubel, O.

    2017-06-01

    Electronic properties of III-V semiconductor alloys are examined using first principles, with the focus on the spatial localization of electronic states. We compare localization at the band edges due to various isovalent impurities in a host GaAs, including its impact on the photoluminescence linewidths and carrier mobilities. The extremity of localization at the band edges is correlated with the ability of individual elements to change the band gap and the relative band alignment. Additionally, the formation energies of substitutional defects are calculated and linked to challenges associated with the growth and formability of alloys. A spectrally resolved inverse participation ratio is used to map localization in prospective GaAs-based materials alloyed with B, N, In, Sb, and Bi for 1.55 -μ m -wavelength telecommunication lasers. This analysis is complemented by a band unfolding of the electronic structure and a discussion of the implications of localization on the optical gain and Auger losses. Correspondence with experimental data on the broadening of the photoluminescence spectrum and charge-carrier mobilities show that the localization characteristics can serve as a guideline for the engineering of semiconductor alloys.

  20. Constipation in children: an epidemiological study in Sri Lanka using Rome III criteria.

    Science.gov (United States)

    Rajindrajith, Shaman; Devanarayana, Niranga Manjuri; Adhikari, Chandralatha; Pannala, Waruni; Benninga, Marc A

    2012-01-01

    Constipation is a common paediatric problem, but its prevalence in Asia is unknown. A cross-sectional survey using a previously validated, self-administered questionnaire was conducted in randomly selected children aged 10-16 years, in five randomly selected schools in Sri Lanka. Two schools were in Eastern Province, which has been affected by the separatist war. Constipation was defined using Rome III criteria. Of 2694 children included in the analysis, 416 (15.4%) had constipation. Symptoms independently associated with constipation were straining (71.6% vs 28.4% of controls), bleeding per rectum (14.2% vs 2.2%) and abdominal pain (55% vs 35.2%). The prevalence of constipation was significantly higher in those with a family history of constipation (49% vs 14.8%), living in a war affected area (18.1% vs 13.7%) and attending an urban school (16.7% vs 13.3%). In conclusion, chronic constipation is a significant problem affecting 15% of Sri Lankan school children and adolescents.

  1. Painlevé III a case study in the geometry of meromorphic connections

    CERN Document Server

    Guest, Martin A

    2017-01-01

    The purpose of this monograph is two-fold:  it introduces a conceptual language for the geometrical objects underlying Painlevé equations,  and it offers new results on a particular Painlevé III equation of type  PIII (D6), called PIII (0, 0, 4, −4), describing its relation to isomonodromic families of vector bundles on P1  with meromorphic connections.  This equation is equivalent to the radial sine (or sinh) Gordon equation and, as such, it appears widely in geometry and physics.   It is used here as a very concrete and classical illustration of the modern theory of vector bundles with meromorphic connections. Complex multi-valued solutions on C* are the natural context for most of the monograph, but in the last four chapters real solutions on R>0 (with or without singularities) are addressed.  These provide examples of variations of TERP structures, which are related to  tt∗ geometry and harmonic bundles.    As an application, a new global picture of0 is given.

  2. Complexation of the sodium cation with sodium ionophore III: Experimental and theoretical study

    Science.gov (United States)

    Makrlík, Emanuel; Kvíčala, Jaroslav; Vaňura, Petr

    2014-06-01

    By using extraction experiments and γ-activity measurements, the extraction constant corresponding to the equilibrium Na+(aq) + A-(aq) + 1(nb) ⇄ 1·Na+(nb) + A-(nb) occurring in the two-phase water - nitrobenzene system (A- = picrate, 1 = sodium ionophore III; aq = aqueous phase, nb = nitrobenzene phase) was determined as log Kex (1·Na+, A-) = 1.5 ± 0.1. Further, the stability constant of the 1·Na+ complex in nitrobenzene saturated with water was calculated for a temperature of 25 °C: log βnb (1·Na+) = 6.7 ± 0.1. Finally, applying quantum mechanical DFT calculations, the most probable structure of the nonhydrated 1·Na+ and hydrated 1·Na+·2H2O cationic complex species were derived. In both of these complexes, the “central” cation Na+ is bound by four bonding interactions to the corresponding four oxygen atoms of the parent ligand 1. Besides, in the case of 1·Na+·2H2O complex, the considered hydrated structure is stabilized by two water molecules bound to the “central” sodium cation.

  3. Sensitivity analysis for III-V/Si tandem solar cells: A theoretical study

    Science.gov (United States)

    Thway, Maung; Ren, Zekun; Liu, Zhe; Chua, Soo Jin; Aberle, Armin G.; Buonassisi, Tonio; Marius Peters, Ian; Lin, Fen

    2017-08-01

    Material and structural parameters may affect the efficiency of a tandem solar cell differently from the way they do in a single-junction solar cell. We fabricated a III-V/Si four-terminal tandem solar cell and developed an opto-electronic model simulating this device. The optical properties were simulated with the transfer matrix method, while the electrical properties were simulated using the numerical device simulator PC1D. For this simulated tandem structure, we determined the parameters which have the largest potential impact on the device efficiency. A sensitivity analysis of the impact of these parameters on the device efficiency was also performed. In addition, to reduce the cost of the tandem solar cells, we identified the parameters that do not require tight control during the manufacturing process. The Si cell was simulated both as a single-junction cell and as the bottom cell of a tandem device. Finally, we determined those device parameters that are more critical in a tandem configuration than in a single-junction configuration.

  4. Anisotropy of the nitrogen conduction states in the group III nitrides studied by polarized x-ray absorption

    Energy Technology Data Exchange (ETDEWEB)

    Lawniczak-Jablonska, K. [Lawrence Berkeley National Lab., CA (United States)]|[Institute of Physics, Warsaw (Poland); Liliental-Weber, Z.; Gullikson, E.M. [Lawrence Berkeley National Lab., CA (United States)] [and others

    1997-04-01

    Group III nitrides (AlN, GaN, and InN) consist of the semiconductors which appear recently as a basic materials for optoelectronic devices active in the visible/ultraviolet spectrum as well as high-temperature and high-power microelectronic devices. However, understanding of the basic physical properties leading to application is still not satisfactory. One of the reasons consists in unsufficient knowledge of the band structure of the considered semiconductors. Several theoretical studies of III-nitrides band structure have been published but relatively few experimental studies have been carried out, particularly with respect to their conduction band structure. This motivated the authors to examine the conduction band structure projected onto p-states of the nitrogen atoms for AlN, GaN and InN. An additional advantage of their studies is the availability of the studied nitrides in two structures, hexagonal (wurtzite) and cubic (zincblende). This offers an opportunity to gain information about the role of the anisotropy of electronic band states in determining various physical properties.

  5. Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine

    Directory of Open Access Journals (Sweden)

    Carter Terrell

    2011-08-01

    Full Text Available Abstract Background A pivotal phase III study of the RTS,S/AS01 malaria candidate vaccine is ongoing in several research centres across Africa. The development and establishment of quality systems was a requirement for trial conduct to meet international regulatory standards, as well as providing an important capacity strengthening opportunity for study centres. Methods Standardized laboratory methods and quality assurance processes were implemented at each of the study centres, facilitated by funding partners. Results A robust protocol for determination of parasite density based on actual blood cell counts was set up in accordance with World Health Organization recommendations. Automated equipment including haematology and biochemistry analyzers were put in place with standard methods for bedside testing of glycaemia, base excess and lactacidaemia. Facilities for X-rays and basic microbiology testing were also provided or upgraded alongside health care infrastructure in some centres. External quality assurance assessment of all major laboratory methods was established and method qualification by each laboratory demonstrated. The resulting capacity strengthening has ensured laboratory evaluations are conducted locally to the high standards required in clinical trials. Conclusion Major efforts by study centres, together with support from collaborating parties, have allowed standardized methods and robust quality assurance processes to be put in place for the phase III evaluation of the RTS, S/AS01 malaria candidate vaccine. Extensive training programmes, coupled with continuous commitment from research centre staff, have been the key elements behind the successful implementation of quality processes. It is expected these activities will culminate in healthcare benefits for the subjects and communities participating in these trials. Trial registration Clinicaltrials.gov NCT00866619

  6. Time-Resolved Laser Fluorescence Spectroscopy Study of the Coordination Chemistry of a Hydrophilic CHON [1,2,3-Triazol-4-yl]pyridine Ligand with Cm(III) and Eu(III).

    Science.gov (United States)

    Wagner, Christoph; Mossini, Eros; Macerata, Elena; Mariani, Mario; Arduini, Arturo; Casnati, Alessandro; Geist, Andreas; Panak, Petra J

    2017-02-20

    The complexation of Cm(III) and Eu(III) with the novel i-SANEX complexing agent 2,6-bis[1-(propan-1-ol)-1,2,3-triazol-4-yl]pyridine (PTD) was studied by time-resolved laser fluorescence spectroscopy (TRLFS). The formation of 1:3, 1:2, and 1:1 metal/ligand complexes was identified upon increasing PTD concentration in 10(-3) mol/L HClO4 and in 0.44 mol/L HNO3 solutions. For all these complexes, stability constants were determined at different acid concentrations. Though under the extraction conditions proposed for an An/Ln separation process, that is, for 0.08 mol/L PTD in 0.44 mol/L HNO3, 1:3 complexes represent the major species, a significant fraction of 1:2 complexes was found. This is caused by ligand protonation, and results in lower Eu(III)/Am(III) separation factors compared to SO3-Ph-BTP, until now considered the i-SANEX reference ligand. Focused extraction studies performed at lower proton concentration, where the 1:3 complex is formed exclusively, confirm this assumption.

  7. Procollagen type III amino terminal peptide and myocardial fibrosis: A study in hypertensive patients with and without left ventricular hypertrophy.

    Science.gov (United States)

    dos Santos Moreira, Carlos; Serejo, Fátima; Alcântara, Paula; Ramalhinho, Vítor; Braz Nogueira, J

    2015-05-01

    An exaggerated accumulation of type I and type III fibrillar collagens occurs throughout the free wall and interventricular septum of patients with primary hypertension and left ventricular hypertrophy (LVH). In the present study the serum concentration of procollagen type III amino terminal peptide (PIIIP) was measured to determine the value of this peptide as a potential marker of ventricular fibrosis in hypertensive patients, particularly those with LVH. The study population consisted of patients with never-treated mild to moderate essential hypertension and 30 normotensive control subjects. Clinical, echocardiographic, electrocardiographic and biochemical parameters were assessed in all patients. Heart rate, body mass index and levels of blood pressure were increased in hypertensives, particularly those with LVH, compared to normotensive controls. Posterior wall thickness, left ventricular (LV) mass and LV mass index, and serum PIIIP concentration were also increased in hypertensives, with significant differences between the two hypertensive groups. The ratio between maximal early and late transmitral flow velocity measured during diastole was lower in hypertensives, particularly those with LVH, than in normotensive controls. The increase in PIIIP indicates that type III collagen synthesis increases in hypertensives, particularly those with LVH, implying that alterations in the heart in hypertension are the result not solely of hypertrophied LV muscle, but also of increased collagen deposition within the ventricular wall and around the coronary vessels. Thus, measurement of serum PIIIP could be a practical and useful tool in the non-invasive assessment of myocardial remodeling in hypertension. Copyright © 2014 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.

  8. Whole-Body Electromyostimulation to Fight Osteopenia in Elderly Females: The Randomized Controlled Training and Electrostimulation Trial (TEST-III).

    Science.gov (United States)

    von Stengel, Simon; Bebenek, Michael; Engelke, Klaus; Kemmler, Wolfgang

    2015-01-01

    Whole-body electromyostimulation (WB-EMS) has been shown to be effective in increasing muscle strength and mass in elderly women. Because of the interaction of muscles and bones, these adaptions might be related to changes in bone parameters. 76 community-living osteopenic women 70 years and older were randomly assigned to either a WB-EMS group (n = 38) or a control group (CG: n = 38). The WB-EMS group performed 3 sessions every 14 days for one year while the CG performed gymnastics containing identical exercises without EMS. Primary study endpoints were bone mineral density (BMD) at lumbar spine (LS) and total hip (thip) as assessed by DXA. After 54 weeks of intervention, borderline nonsignificant intergroup differences were determined for LS-BMD (WB-EMS: 0.6 ± 2.5% versus CG -0.7 ± 2.5%, P = .051) but not for thip-BMD (WB-EMS: -1.1 ± 1.9% versus CG: -0.8 ± 2.3%, P = .771). With respect to secondary endpoints, there was a gain in lean body mass (LBM) of 1.5% (P = .006) and an increase in grip strength of 8.4% (P = .000) in the WB-EMS group compared to CG. WB-EMS effects on bone are less pronounced than previously reported effects on muscle mass. However, for subjects unable or unwilling to perform intense exercise programs, WB-EMS may be an option for maintaining BMD at the LS.

  9. Whole-Body Electromyostimulation to Fight Osteopenia in Elderly Females: The Randomized Controlled Training and Electrostimulation Trial (TEST-III

    Directory of Open Access Journals (Sweden)

    Simon von Stengel

    2015-01-01

    Full Text Available Whole-body electromyostimulation (WB-EMS has been shown to be effective in increasing muscle strength and mass in elderly women. Because of the interaction of muscles and bones, these adaptions might be related to changes in bone parameters. 76 community-living osteopenic women 70 years and older were randomly assigned to either a WB-EMS group (n=38 or a control group (CG: n=38. The WB-EMS group performed 3 sessions every 14 days for one year while the CG performed gymnastics containing identical exercises without EMS. Primary study endpoints were bone mineral density (BMD at lumbar spine (LS and total hip (thip as assessed by DXA. After 54 weeks of intervention, borderline nonsignificant intergroup differences were determined for LS-BMD (WB-EMS: 0.6±2.5% versus CG -0.7±2.5%, P=.051 but not for thip-BMD (WB-EMS: -1.1±1.9% versus CG: -0.8±2.3%, P=.771. With respect to secondary endpoints, there was a gain in lean body mass (LBM of 1.5% (P=.006 and an increase in grip strength of 8.4% (P=.000 in the WB-EMS group compared to CG. WB-EMS effects on bone are less pronounced than previously reported effects on muscle mass. However, for subjects unable or unwilling to perform intense exercise programs, WB-EMS may be an option for maintaining BMD at the LS.

  10. Whole-Body Electromyostimulation to Fight Osteopenia in Elderly Females: The Randomized Controlled Training and Electrostimulation Trial (TEST-III)

    Science.gov (United States)

    von Stengel, Simon; Bebenek, Michael

    2015-01-01

    Whole-body electromyostimulation (WB-EMS) has been shown to be effective in increasing muscle strength and mass in elderly women. Because of the interaction of muscles and bones, these adaptions might be related to changes in bone parameters. 76 community-living osteopenic women 70 years and older were randomly assigned to either a WB-EMS group (n = 38) or a control group (CG: n = 38). The WB-EMS group performed 3 sessions every 14 days for one year while the CG performed gymnastics containing identical exercises without EMS. Primary study endpoints were bone mineral density (BMD) at lumbar spine (LS) and total hip (thip) as assessed by DXA. After 54 weeks of intervention, borderline nonsignificant intergroup differences were determined for LS-BMD (WB-EMS: 0.6 ± 2.5% versus CG −0.7 ± 2.5%, P = .051) but not for thip-BMD (WB-EMS: −1.1 ± 1.9% versus CG: −0.8 ± 2.3%, P = .771). With respect to secondary endpoints, there was a gain in lean body mass (LBM) of 1.5% (P = .006) and an increase in grip strength of 8.4% (P = .000) in the WB-EMS group compared to CG. WB-EMS effects on bone are less pronounced than previously reported effects on muscle mass. However, for subjects unable or unwilling to perform intense exercise programs, WB-EMS may be an option for maintaining BMD at the LS. PMID:25785225

  11. Polymorphism in Commercial Sources of Fusidic Acid: A Comparative Study of the In Vitro Release Characteristics of Forms I and III from a Marketed Pharmaceutical Cream

    Directory of Open Access Journals (Sweden)

    Jonathan Byrne

    2017-01-01

    Full Text Available A comparison of the polymorphic forms of 3 commercial sources of fusidic acid using FTIR and XRPD techniques has been performed in this study. It has been demonstrated that polymorphic Forms I and III are currently available on the commercial market. The influence of the observed polymorphism on the stability of the drug substance in bulk form has been investigated through stability and stress testing according to current ICH guidelines. Significant differences were detected between commercial sources with regard to the stability of the bulk substance under photolytic and humidity stress conditions. When properly packaged in an inert atmosphere, fusidic acid from all 3 manufacturers showed a comparable stability. The effects of the observed polymorphic differences on the intrinsic dissolution rate of the drug substance and its in vitro release from the marketed drug product Fusicutan® plus Betamethasone cream have been investigated. Results indicated that the release rate of the drug substance is similar for polymorphic Forms I and III, allowing both forms to be used during manufacture without affecting the safety or efficacy of the drug product.

  12. An evaluation of the hemiplegic subject based on the Bobath approach. Part III. A validation study.

    Science.gov (United States)

    Arsenault, A B; Dutil, E; Lambert, J; Corriveau, H; Guarna, F; Drouin, G

    1988-01-01

    Sixty-two hemiplegic subjects were treated with the Bobath approach for a period of three months. During this time they were evaluated on three occasions. The testing battery consisted of a Bobath evaluation, the Brunnstrom scale, the Fugl-Meyer test, the Upper Extremity Functional Test (UEFT) and the Present Pain Intensity (PPI) of the McGill pain questionnaire. A Friedman analysis of variance showed that, except for pain, all the protocols used disclosed significant progress (p less than 0.001) over time in terms of motor recovery. Except for pain, the results of the Bobath evaluation were significantly correlated (Spearman's Rho, p less than 0.001) with the results of the other testing procedures. It is concluded that the new Bobath evaluation proposed in a previous paper is as sensitive in depicting progress in motor recovery over time as are the other testing procedures used. Furthermore, this new evaluation seems to be measuring similar properties to the other tests. However, pain (PPI) appears not to be an important dependent variable.

  13. Highway concrete pavement technology development and testing : volume III, field evaluation of Strategic Highway Research Program (SHRP) C-205 test sites (high-performance concrete).

    Science.gov (United States)

    2006-05-01

    This research study, sponsored by the Federal Highway Administration, summarizes the field performance of eight high-early-strength (HES) : concrete patches between 1994 and 1998. The patches were constructed under the Strategic Highway Research Prog...

  14. Vibroacoustic test plan evaluation: Parameter variation study

    Science.gov (United States)

    Stahle, C. V.; Gongloef, H. R.

    1976-01-01

    Statistical decision models are shown to provide a viable method of evaluating the cost effectiveness of alternate vibroacoustic test plans and the associated test levels. The methodology developed provides a major step toward the development of a realistic tool to quantitatively tailor test programs to specific payloads. Testing is considered at the no test, component, subassembly, or system level of assembly. Component redundancy and partial loss of flight data are considered. Most and probabilistic costs are considered, and incipient failures resulting from ground tests are treated. Optimums defining both component and assembly test levels are indicated for the modified test plans considered. modeling simplifications must be considered in interpreting the results relative to a particular payload. New parameters introduced were a no test option, flight by flight failure probabilities, and a cost to design components for higher vibration requirements. Parameters varied were the shuttle payload bay internal acoustic environment, the STS launch cost, the component retest/repair cost, and the amount of redundancy in the housekeeping section of the payload reliability model.

  15. Transport Network Technologies – Study and Testing

    DEFF Research Database (Denmark)

    Bozorgebrahimi, K.; Channegowda, M.; Colmenero, A.

    Following on from the theoretical research into Carrier Class Transport Network Technologies (CCTNTs) documented in DJ1.1.1, this report describes the extensive testing performed by JRA1 Task 1. The tests covered EoMPLS, Ethernet OAM, Synchronous Ethernet, PBB-TE, MPLS-TP, OTN and GMPLS, and the ......Following on from the theoretical research into Carrier Class Transport Network Technologies (CCTNTs) documented in DJ1.1.1, this report describes the extensive testing performed by JRA1 Task 1. The tests covered EoMPLS, Ethernet OAM, Synchronous Ethernet, PBB-TE, MPLS-TP, OTN and GMPLS...

  16. Switching patients with acromegaly from octreotide to pasireotide improves biochemical control: Crossover extension to a randomized, double-blind, Phase III study

    NARCIS (Netherlands)

    M.D. Bronstein (Marcello); Fleseriu, M. (Maria); S.J.C.M.M. Neggers (Bas); A. Colao (Annamaria); Sheppard, M. (Michael); Gu, F. (Feng); Shen, C.-C. (Chiung-Chyi); M.R. Gadelha (Mônica R.); Farrall, A.J. (Andrew J.); Reséndiz, K.H. (Karina Hermosillo); Ruffin, M. (Matthieu); Chen, Y. (YinMiao); P.U. Freda (Pamela)

    2016-01-01

    markdownabstractBackground Many patients with acromegaly do not achieve biochemical control with first-generation somatostatin analogues. A large, multicenter, randomized, Phase III core study demonstrated that pasireotide LAR had significantly superior efficacy over octreotide LAR. This analysis

  17. Correction: Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study.

    Science.gov (United States)

    Tomin, M; Tomić, S

    2017-11-21

    Correction for 'Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study' by M. Tomin et al., Mol. BioSyst., 2017, 13, 2407-2417.

  18. Comparison of the condyle-fossa relationship between skeletal class III malocclusion patients with and without asymmetry: a retrospective three-dimensional cone-beam computed tomograpy study

    National Research Council Canada - National Science Library

    Hyoun Oak Kim; Won Lee; Yoon-Ah Kook; Yoonji Kim

    2013-01-01

    This study investigated whether temporomandibular joint (TMJ) condyle-fossa relationships are bilaterally symmetric in class III malocclusion patients with and without asymmetry and compared to those with normal occlusion...

  19. Growth and Carrier Transport Studies of III-Nitride Alloys by Ammonia Molecular Beam Epitaxy

    Science.gov (United States)

    Browne, David Alan

    The III-Nitride alloys span the entire visible spectrum and offer applications to LEDs, lasers, solar cells and power electronics. A detailed understanding of heterojunction growth is required for achieving high performance devices especially due to the large lattice mismatch in this alloy system. The wurtzite crystal system also lacks an inversion center which provides a polarization-induced electric field along the c direction that can be exploited in device design or reduced by growth on other substrate orientations. We present results on the growth of InGaN films by Ammonia MBE on polar gallium nitride substrates as well as on nonpolar and semipolar orientations. We show results from coloaded growth conditions and investigate the effect of substrate temperature, growth rate, and ammonia flow on indium incorporation and impurity uptake. We then present solar cell results from a high indium uptake semipolar orientation with fields in a favorable direction for a p-i-n device. We also investigate and understand the effect of relaxation via basal plane slip and unintentional impurity incorporation on device performance. Results are then be presented on electron transport through c plane InGaN/GaN multiple quantum well (MQW) active regions grown by NH3 MBE which have direct relevance to transport in MQW solar cells and LEDs. The presence of indium fluctuations in InGaN has been suspected and debated in the literature for some time, but there is still much that is not well understood. We present Atom Probe Tomography (APT) analysis of the quantum wells to explicitly examine the magnitude and length scale of these observed local alloy fluctuations. The discrepancy in current-voltage behavior between experiment and modeling using traditional 1D simulation software will be discussed. A 2D/3D drift-diffusion Schrodinger-Poisson solver developed by collaborators was used to input alloy fluctuation parameters to elucidate their direct effect on barrier heights and on

  20. Study on competitive adsorption mechanism among oxyacid-type heavy metals in co-existing system: Removal of aqueous As(V), Cr(III) and As(III) using magnetic iron oxide nanoparticles (MIONPs) as adsorbents

    Science.gov (United States)

    Lin, Sen; Lian, Cheng; Xu, Meng; Zhang, Wei; Liu, Lili; Lin, Kuangfei

    2017-11-01

    The adsorption and co-adsorption of As(V), Cr(VI) and As(III) onto the magnetic iron oxide nanoparticles (MIONPs) surface were investigated comprehensively to clarify the competitive processes. The results reflected that the MIONPs had remarkable preferential adsorption to As(V) compared with Cr(VI) and As(III). And it was determined, relying on the analysis of heavy metals variations on the MIONPs surface at different co-adsorption stages using FTIR and XPS, that the inner-sphere complexation made vital contribution to the preferential adsorption for As(V), corresponding with the replacement experiments where As(V) could grab extensively active sites on the MIONPs pre-occupied by As(III) or Cr(V) uniaxially. The desorption processes displayed that the strongest affinity between the MIONPs and As(V) where As(III) and Cr(VI) were more inclined to wash out. It is wish to provide a helpful direction with this study for the wastewater treatment involving multiple oxyacid-type heavy metals using MIONPs as adsorbents.

  1. Nuclear anxiety: a test-construction study

    Energy Technology Data Exchange (ETDEWEB)

    Braunstein, A.L.

    1986-01-01

    The Nuclear Anxiety Scale was administered to 263 undergraduate and graduate studies (on eight occasions in December, 1985 and January, 1986). (1) The obtained alpha coefficient was .91. This was significant at the .01 level, and demonstrated that the scale was internally homogeneous and consistent. (2) Item discrimination indices (point biserial correlation coefficients) computered for the thirty (30) items yielded a range of .25 to .64. All coefficients were significant at the .01 level, and all 30 items were retained as demonstrating significant discriminability. (3) The correlation between two administrations of the scale (with a 48-hour interval) was .83. This was significant at the .01 level, and demonstrated test-retest reliability and stability over time. (4) The point-biserial correlation coefficient between scores on the Nuclear Anxiety Scale, and the students' self-report of nuclear anxiety as being either a high or low ranked stressor, was .59. This was significant at the .01 level, and demonstrated concurrent validity. (5) The correlation coefficient between scores on the Nuclear Anxiety Scale and the Spielberger State-Trait Anxiety Inventory, A-Trait, (1970), was .41. This was significant at the .01 level, and demonstrated convergent validity. (6) The correlation coefficient between positively stated and negatively stated items (with scoring reversed) was .76. This was significant at the .01 level, and demonstrated freedom from response set bias.

  2. [A study on the difference between International Diabetes Federation worldwide definition and Adult Treatment Panel III in diagnosing metabolic syndrome].

    Science.gov (United States)

    Xie, Zi-Jing; Guo, Nian-Kun; Mao, Xin-Min; Li, Lin-Lin

    2008-01-01

    To study the difference between the metabolic syndrome (MS) diagnosis made with International Diabetes Federation (IDF) worldwide definition and the Adult Treatment Panel III (ATPIII) of National Cholesterol Education Program (NCEP). Cross-sectional study and descriptive study were used. There were 1328 MS patients diagnosed with IDF and 1527 MS patients diagnosed with ATPIII. There were 199 MS patients diagnosed with ATPIII but not with IDF and these MS patients all had 3 - 4 risk factors. According to the abnormality of glucose, blood pressure and lipid regulation stated in ATPIII criteria, 759 more patients were diagnosed as MS than with IDF criteria. MS diagnosed with ATPIII criteria is more objective than with IDF criteria and ATPIII criteria has more space for further theoretical study.

  3. Microwave assisted synthesis, spectroscopic, electrochemical and DNA cleavage studies of lanthanide(III) complexes with coumarin based imines.

    Science.gov (United States)

    Kapoor, Puja; Fahmi, Nighat; Singh, R V

    2011-12-01

    The present work stems from our interest in the synthesis, characterization and biological evaluation of lanthanide(III) complexes of a class of coumarin based imines which have been prepared by the interaction of hydrated lanthanide(III) chloride with the sodium salts of 3-acetylcoumarin thiosemicarbazone (ACTSZH) and 3-acetylcoumarin semicarbazone (ACSZH) in 1:3 molar ratio using thermal as well as microwave method. Characterization of the ligands as well as the metal complexes have been carried out by elemental analysis, melting point determinations, molecular weight determinations, magnetic moment, molar conductance, IR, (1)H NMR, (13)C NMR, electronic, EPR, X-ray powder diffraction and mass spectral studies. Spectral studies confirm ligands to be monofunctional bidentate and octahedral environment around metal ions. The redox behavior of one of the synthesized metal complex was investigated by cyclic voltammetry. Further, free ligands and their metal complexes have been screened for their antimicrobial as well as DNA cleavage activity. The results of these findings have been presented and discussed. Copyright © 2011 Elsevier B.V. All rights reserved.

  4. A phase I study of dasatinib with concurrent chemoradiation for stage III non small cell lung cancer (NSCLC

    Directory of Open Access Journals (Sweden)

    Howard eSafran

    2012-05-01

    Full Text Available Objectives: Src family kinases (SFKs are expressed in NSCLC and may be involved in tumor growth and metastases. Inhibition of SFK may also enhance radiation. The purpose of this study was to evaluate if a maximum dose of 100 mg of dasatinib could be safely administered with concurrent chemoradiation and then continued as maintenance for patients with newly diagnosed stage III NSCLC.Methods: Patients with stage III locally advanced NSCLC received paclitaxel, 50mg/m2/week, with carboplatin area under the curve (AUC = 2, weekly for 7 weeks, and concurrent radiotherapy, 64.8 Gy. Three dose levels of dasatinib 50, 70 and 100mg/day were planned.Results: Eleven patients with locally advanced NSCLC were entered. At the 70 mg dose level 1 patient had grade 5 pneumonitis not responsive to therapy, and 1 patient had reversible grade 3 pneumonitis and grade 3 pericardial effusion. Due to these toxicities the Brown University Oncology Group Data Safety Monitoring Board terminated the study. Conclusion: Dasatinib could not be safely combined with concurrent chemoradiation for stage 3 lung cancer due to pneumonitis.

  5. A phase III, randomized, non-inferiority study comparing the efficacy and safety of biosimilar filgrastim versus originator filgrastim for chemotherapy-induced neutropenia in breast cancer patients

    Science.gov (United States)

    Hegg, Roberto; Mattar, André; de Matos, João Nunes; Pedrini, José Luiz; Aleixo, Sabina Bandeira; Rocha, Roberto Odebrecht; Cramer, Renato Peixoto; van-Eyll-Rocha, Sylvie

    2016-01-01

    OBJECTIVES: To compare the efficacy and safety of two filgrastim formulations for controlling chemotherapy-induced neutropenia and to evaluate the non-inferiority of the test drug relative to the originator. METHODS: This phase III non-inferiority study had a randomized, multicenter, and open-label design. The patients were randomized at a ratio of 1:1 with a follow-up period of 6 weeks for each patient. In both study arms, filgrastim was administered subcutaneously at a daily dose of 5 mg/kg body weight. The primary endpoint was the rate of grade 4 neutropenia in the first treatment cycle. The secondary endpoints were the duration of grade 4 neutropenia, the generation of anti-filgrastim antibodies, and the rates of adverse events, laboratory abnormalities, febrile neutropenia, and neutropenia of any grade. RESULTS: The primary efficacy analysis demonstrated the non-inferiority of the test drug compared with the originator drug; the upper limit of the 90% confidence interval (CI) for the rate of neutropenia between the two groups (12.61%) was lower than the established margin of non-inferiority. The two treatments were similar with respect to the secondary endpoints and safety. CONCLUSION: The efficacy and safety profile of the test drug were similar to those of the originator product based on the rate of grade 4 neutropenia in the first treatment cycle. This study supports Anvisa's approval of the first biosimilar drug manufactured by the Brazilian industry (Fiprima®). PMID:27759847

  6. Experimental and Theoretical Studies on the Structure and Photoluminescent Properties of New Mononuclear and Homodinuclear Europium(III β-Diketonate Complexes

    Directory of Open Access Journals (Sweden)

    João P. Martins

    2015-01-01

    Full Text Available Two novel europium(III complexes, a monomer and a homodimer, with 1-(4-chlorophenyl-4,4,4-trifluoro-1,3-butanedione (Hcbtfa and 5-chloro-1,10-phenanthroline (cphen ligands, formulated as [Eu(cbtfa3(cphen] and [Eu2(cbtfa4(cphen2(CH3O2], have been synthesized. Their structures have been elucidated by X-ray diffraction and their absorption and emission properties have been studied in the solid state. The experimental data has then been used to test the recently released LUMPAC software, a promising tool which can facilitate the design of more efficient lanthanide light-conversion molecular devices by combining ground state geometry, excited state energy, and luminescent properties calculations.

  7. Spectroscopic studies of micelle-enhanced ligand exchange of gallium (III)/4-(2-pyridylazo) resorcinol complex by calf thymus DNA.

    Science.gov (United States)

    Romeika, Jennifer M; Spurgeon, Charina L; Yan, Fei

    2014-01-03

    The effect of cationic micelles of cetyltrimethylammonium bromide (CTAB) on the interaction of gallium (III) with 4-(2-pyridylazo) resorcinol (PAR) under varying conditions has been studied spectrophotometrically. At pH 6.0, CTAB (0.05% w/v) markedly enhanced the absorption intensity of gallium (III)-PAR complex. Furthermore, the introduction of CTAB provided unique selectivity for the ligand exchange of Ga(III)-PAR by calf thymus dsDNA over calf thymus ssDNA. This phenomenon offers a novel spectrophotometric sensing strategy for direct detection of dsDNA. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. A Longitudinal Study of Grade III Achievement in Edmonton Public Schools.

    Science.gov (United States)

    Nyberg, V. R.; Blackmore, D. E.

    1981-01-01

    Achievement tests administered to grade three students indicated that the overall level of communication skills had increased from 1956 to 1977, while mathematical skills had decreased slightly. Decline in mathematics scores was not general but was related to items in specific areas. (Author/CM)

  9. Page 1 Studies on the Microbial Spoilage of Canned Food-III 265 In ...

    Indian Academy of Sciences (India)

    In order to find out the optimum pH range for growth of the organism, nutrient agar, adjusted to different pH levels, was prepared in the usual manner, poured in petri-dishes and the test organism inoculated by streaking all over the surface of the medium. The dishes were incubated for four days at room temperature and the ...

  10. Operation of Wastewater Treatment Plants: A Field Study Training Program. Volume III, Instructor's Guide. Second Edition.

    Science.gov (United States)

    California State Univ., Sacramento. Dept. of Civil Engineering.

    The objective of this instructor's guide is to help provide students with knowledge and skills for employment in the field of wastewater treatment. Included in each chapter outline are: (1) objectives, (2) instructional approach, (3) answers to the objective test in the student's text, and (4) an explanation of these answers. The material…

  11. Icosapent ethyl (eicosapentaenoic acid ethyl ester): Effects on plasma apolipoprotein C-III levels in patients from the MARINE and ANCHOR studies.

    Science.gov (United States)

    Ballantyne, Christie M; Bays, Harold E; Braeckman, Rene A; Philip, Sephy; Stirtan, William G; Doyle, Ralph T; Soni, Paresh N; Juliano, Rebecca A

    2016-01-01

    Apolipoprotein C-III (ApoC-III) regulates lipoprotein and triglyceride (TG) metabolism and may have a causal role in cardiovascular disease. In the Multi-Center, Placebo-Controlled, Randomized, Double-Blind, 12-Week Study With an Open-Label Extension (MARINE) and ANCHOR studies, icosapent ethyl, a high-purity prescription eicosapentaenoic acid ethyl ester, reduced TG, and other atherogenic lipid parameters without increasing low-density lipoprotein cholesterol (LDL-C) compared with placebo. To evaluate the effects of icosapent ethyl on plasma ApoC-III levels in patients from 2 phase 3 studies. MARINE and ANCHOR were 12-week double-blind studies of icosapent ethyl in adult patients. Patients in MARINE had very high TG levels (≥500 and ≤2000 mg/dL) and patients in ANCHOR had high TG levels (≥200 and ANCHOR assessed the median percent change from baseline in plasma ApoC-III levels vs placebo and includes subgroup analyses by statin use/efficacy and median ApoC-III levels. We assessed ApoC-III levels in 148 and 612 patients in the MARINE and ANCHOR studies, respectively. In MARINE, the approved prescription dose of icosapent ethyl (4 g/day) significantly reduced ApoC-III levels by 25.1% (P ANCHOR, icosapent ethyl 4 g/day significantly reduced ApoC-III levels by 19.2% (P ANCHOR studies. Copyright © 2016 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  12. Structure and spectroscopic study of aqueous Fe(III)-As(V) complexes using UV-Vis, XAS and DFT-TDDFT.

    Science.gov (United States)

    Chai, Liyuan; Yang, Jinqin; Zhang, Ning; Wu, Pin-Jiun; Li, Qingzhu; Wang, Qingwei; Liu, Hui; Yi, Haibo

    2017-09-01

    Aqueous complexes between ferric (Fe(III)) and arsenate (As(V)) are indispensable for understanding the mobility of arsenic (As) in Fe(III)-As(V)-rich systems. In this study, aqueous Fe(III)-As(V) complexes, FeH2AsO4(2+) and FeHAsO4(+), were postulated based on the qualitative analysis of UV-Vis spectra in both Fe(III)-As(V)-HClO4 and Fe(III)-As(V)-H2SO4 systems. Subsequently, monodentate structures were evidenced by Fe K-edge EXAFS and modeled as [FeH2AsO4(H2O)5](2+) and [FeHAsO4(H2O)5](+) by DFT. The feature band at ∼280 nm was verified as electron excitation chiefly from Fe-As-bridged O atoms to d-orbital of Fe in [FeH2AsO4(H2O)5](2+) and [FeHAsO4(H2O)5](+). The structural and spectral information of Fe(III)-As(V) complexes will enable future speciation analysis in Fe(III)-As(V)-rich system. Copyright © 2017. Published by Elsevier Ltd.

  13. Radiological and Environmental Monitoring at the Clean Slate I and III Sites, Tonopah Test Range, Nevada, With Emphasis on the Implications for Off-site Transport

    Energy Technology Data Exchange (ETDEWEB)

    Mizell, Steve A [Desert Research Inst. (DRI), Las Vegas, NV (United States); Etyemezian, Vic [Desert Research Inst. (DRI), Las Vegas, NV (United States); McCurdy, Greg [Desert Research Inst. (DRI), Las Vegas, NV (United States); Nikolich, George [Desert Research Inst. (DRI), Las Vegas, NV (United States); Shadel, Craig [Desert Research Inst. (DRI), Las Vegas, NV (United States); Miller, Julianne J [Desert Research Inst. (DRI), Las Vegas, NV (United States)

    2014-09-01

    In 1963, the U.S. Department of Energy (DOE) (formerly the Atomic Energy Commission [AEC]) implemented Operation Roller Coaster on the Tonopah Test Range (TTR) and an adjacent area of the Nevada Test and Training Range (NTTR) (formerly the Nellis Air Force Range [NAFR]). Operation Roller Coaster consisted of four tests in which chemical explosions were detonated in the presence of nuclear devices to assess the dispersal of radionuclides and evaluate the effectiveness of storage structures to contain the ejected radionuclides. These tests resulted in the dispersal of plutonium over the ground surface downwind of the test ground zero (GZ). Three tests—Clean Slate I, II, and III—were conducted on the TTR in Cactus Flat. The fourth, Double Tracks, was conducted in Stonewall Flat on the NTTR. The Desert Research Institute (DRI) installed two monitoring stations in 2008, Station 400 at the Sandia National Laboratories (SNL) Range Operations Center (ROC) and Station 401 at Clean Slate III. Station 402 was installed at Clean Slate I in 2011 to measure radiological, meteorological, and dust conditions. The monitoring activity was implemented to determine if radionuclide contamination in the soil at the Clean Slate sites was being transported beyond the contamination area boundaries. Some of the data collected also permits comparison of radiological exposure at the TTR monitoring stations to conditions observed at Community Environmental Monitoring Program (CEMP) stations around the NTTR. Annual average gross alpha values from the TTR monitoring stations are higher than values from the surrounding CEMP stations. Annual average gross beta values from the TTR monitoring stations are generally lower than values observed for the surrounding CEMP stations. This may be due to use of sample filters with larger pore space because when glass-fiber filters began to be used at TTR Station 400, gross beta values increased. Gamma spectroscopy typically identified only naturally

  14. Synthesis, structure, theoretical studies and luminescent properties of a ternary erbium(III) complex with acetylacetone and bathophenanthroline ligands

    Energy Technology Data Exchange (ETDEWEB)

    Martín-Ramos, Pablo [CEMDRX, Department of Physics, Universidade de Coimbra, Rua Larga, P-3004-516 Coimbra (Portugal); Advanced Materials Laboratory, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia (Spain); Silva, Pedro S. Pereira, E-mail: psidonio@pollux.fis.uc.pt [CEMDRX, Department of Physics, Universidade de Coimbra, Rua Larga, P-3004-516 Coimbra (Portugal); Chamorro-Posada, Pedro [Higher Technical School of Telecommunications Engineering, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid (Spain); Silva, Manuela Ramos [CEMDRX, Department of Physics, Universidade de Coimbra, Rua Larga, P-3004-516 Coimbra (Portugal); Milne, Bruce F. [Centre for Computational Physics, Department of Physics, Universidade de Coimbra, P-3004-516 Coimbra (Portugal); Donostia International Physics Centre, Paseo Manuel de Lardizabal 4, 20018 Donostia-San Sebastián (Spain); Nogueira, Fernando [Centre for Computational Physics, Department of Physics, Universidade de Coimbra, P-3004-516 Coimbra (Portugal); Martín-Gil, Jesús [Advanced Materials Laboratory, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia (Spain)

    2015-06-15

    A novel erbium(III) complex with acetylacetone (Hacac) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline, bath) ligands, formulated as [Er(acac){sub 3}(bath)], has been characterized by elemental analysis, X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, Raman spectroscopy, absorption and emission spectroscopies. In the theoretical part of this study, semi-empirical quantum chemistry methods using AM1, PM3, PM6 and PM7 models have been employed to predict the structure of the complex, calculate the geometric and crystallographic parameters, and make comparisons with spectroscopic data using INDO/S-CI calculations. Real-time time-dependent density-functional theory (TDDFT) has also been used to calculate the optical absorption spectrum of the complex in the gas phase. - Highlights: • Synthesis and structure of a new erbium(III) β-diketonate complex. • TDDFT used for the first time to calculate the optical absorption spectrum. • Complex show strong near-infrared luminescence at 1.53 µm due to antenna effect.

  15. Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study.

    Science.gov (United States)

    Sharma, Praveen; Dietrich, Thomas; Ferro, Charles J; Cockwell, Paul; Chapple, Iain L C

    2016-02-01

    Periodontitis may add to the systemic inflammatory burden in individuals with chronic kidney disease (CKD), thereby contributing to an increased mortality rate. This study aimed to determine the association between periodontitis and mortality rate (all-cause and cardiovascular disease-related) in individuals with stage 3-5 CKD, hitherto referred to as "CKD". Survival analysis was carried out using the Third National Health and Nutrition Examination Survey (NHANES III) and linked mortality data. Cox proportional hazards regression was employed to assess the association between periodontitis and mortality, in individuals with CKD. This association was compared with the association between mortality and traditional risk factors in CKD mortality (diabetes, hypertension and smoking). Of the 13,784 participants eligible for analysis in NHANES III, 861 (6%) had CKD. The median follow-up for this cohort was 14.3 years. Adjusting for confounders, the 10-year all-cause mortality rate for individuals with CKD increased from 32% (95% CI: 29-35%) to 41% (36-47%) with the addition of periodontitis. For diabetes, the 10-year all-cause mortality rate increased to 43% (38-49%). There is a strong, association between periodontitis and increased mortality in individuals with CKD. Sources of chronic systemic inflammation (including periodontitis) may be important contributors to mortality in patients with CKD. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. A general method, employing arsenazo III in liposomes, for study of calcium ionophores: results with A23187 and prostaglandins.

    Science.gov (United States)

    Weissmann, G; Anderson, P; Serhan, C; Samuelsson, E; Goodman, E

    1980-01-01

    Multilamellar (MLV) and large unilamellar (LUV) lipid vesicles (liposomes) trap the metallochromic dye arsenazo III [2,7-bis(arsonophenylazo)-1,8-dihydroxynaphthalene-3,6-disulfonic acid ] in their aqueous compartments. When ionophore A23187 was preincorporated into either MLV or LUV above 0.001 mol%, addition of Ca to the outside of liposomes produced spectral shifts characteristic of the Ca . AIII2 complex. The method permitted detection of two molecules of A23187 per liposome. Liposomes with A23187 were permselective: divalent cations were translocated in the order Mn greater than Ca greater than Sr greater than Mg congruent to Ba. Because prostaglandins (PGs) may act as Ca ionophores, we have incorporated into MLVs and LUVs stable prostaglandins (PGE2, PGI2, PGB1), endoperoxide analogs, and a water-soluble, polymeric derivative of PGB1:PGBx. None acted as ionophore. In contrast, when added to the outside of preformed MLV or LUV, PGBx, at concentrations above 1 micro M, provoked permselective uptake of Ca equivalent to that induced by 10 nM A23187. These studies demonstrate not only that liposomes containing arsenazo III may be employed in a sensitive asssay for agents that translocate divalent cations, but that a water-soluble derivative of a naturally occurring fatty acid, PGBx, is a potent ionophore. PMID:6769114

  17. Program Corporate Social Responsibility (CSR) dan Citra Perusahaan (Studi Korelasional Program Nikah Massal Terhadap Citra PT. PGN SBU III Medan di Kalangan Warga Masyarakat Kota Medan)

    OpenAIRE

    Sarah, Mia

    2015-01-01

    Penelitian ini berjudul Program Corporate Social Responsibilty (CSR) dan Citra Perusahaan (Studi korelasional Program Nikah Massal terhadap citra PT.PGN SBU III Medan di kalangan warga masyarakat Kota Medan). Adapun tujuan dari penelitian ini adalah untuk mengetahui sejauhmana hubungan antara Program Corporate Social Responsibilty (CSR) Nikah Massal terhadap terhadap citra PT.PGN SBU III Medan. Teori yang digunakan dan dianggap relevan dalam penelitian ini adalah teori Public Relations, t...

  18. CEPHALOMETRIC FEATURES OF CLASS III MALOCCLUSION.

    Science.gov (United States)

    Zegan, Georgeta; Dascălu, Cristina; Mavru, R B; Anistoroaei, Daniela

    2015-01-01

    The study aimed to identify quantitative and relational characteristics of bone, dental and soft tissue structures for Class III malocclusion, according to gender and age range. 60 conventional lateral cephalograms were divided into two groups according to ANB angle: the group of cases with skeletal Class III (n = 36) and a control group with skeletal Class I (n = 24). There were performed 53 digital cephalometric measurements according to Steiner, Tweed and Jarabak analyzes. The Kolmogorov-Smirnov, t-student and Levene tests were used to find the characteristics of Class III, using SPSS 16.0 for Windows. We found 14 parameters that distinguished the two classes disorders (the angles SNB, SND, FMA, IMPA, MeGoOcP, Mand 1-MeGo, NSAr, ArGoMe, NGoMe and SNPog; the distances Ao-Bo and lu-NPog; Holdaway and AFH ratios) and 3 parameters for the Class III age ranges (NGoAr angle, Ls-NsPog' distance and S-Ar:Ar-Go ratio) (p ≤ 0.05). There were found no significant differences between genders for skeletal Class III. Emphasizing the cephalometric characteristics of Class III malocclusion, with the overall growth together with dental and occlusion development, requires early orthodontic therapy.

  19. Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).

    NARCIS (Netherlands)

    Fusi, A.; Collette, S.; Busse, A.; Suciu, S.; Rietz, A.; Santinami, M.; Kruit, W.H.; Testori, A.; Punt, C.J.A.; Dalgleish, A.G.; Spatz, A.; Eggermont, A.M.M.; Keilholz, U.

    2009-01-01

    AIM: To evaluate the prognostic and predictive importance of detection of melanoma cells in peripheral blood using reverse transcriptase polymerase chain reaction (RT-PCR) in stage III cutaneous melanoma patients after sentinel or regional lymph node dissection. PATIENTS AND METHODS: Serial testing

  20. Photophysical study of blue-light excitable ternary Eu(III) complexes and their encapsulation into polystyrene nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Räsänen, Markus, E-mail: mpvras@utu.fi [Department of Chemistry, University of Turku, FIN-20014 Turku (Finland); Takalo, Harri [DHR Finland Oy, Innotrac Diagnostics, Biolinja 12, FIN-20750 Turku (Finland); Soukka, Tero [Department of Biochemistry/Biotechnology, University of Turku, FIN-20014 Turku (Finland); Haapakka, Keijo; Kankare, Jouko [Department of Chemistry, University of Turku, FIN-20014 Turku (Finland)

    2015-04-15

    In this work, 14 ternary Eu(III) complexes were studied by means of spectroscopy. The studied Eu(III) complexes consisted of Lewis bases (4′-(4-diethylaminophenyl)-2,2′:6′,2″-terpyridine (L{sup 8}) or 1,10-phenanthroline (L{sup 9})) and differently substituted β-diketones. The ternary complexes with L{sup 8} show the excitation peak at 405 nm and the quantum yield even 76%. The brightest ternary complex at the 405 nm excitation was Eu(L{sup 3}){sub 3}L{sup 8} while Eu(L{sup 7}){sub 3}L{sup 8} (HL{sup 3}=4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione, HL{sup 7}=1-(9-ethyl-9H-carbazol-3-yl)-4,4,5,5,5-pentafluoro-1,3-pentanedione) was found to be the brightest at the ligand-centred excitation maximum. The ternary complexes were studied mainly in toluene as the model environment for the polystyrene nanoparticle cavities. The complexes were successfully loaded into the polystyrene nanoparticles enabling their bioanalytical application in aqueous environment. The encapsulation of the complexes preserved, or even enhanced, their good photophysical features. - Highlights: • Ternary Eu{sup 3+} complexes with some β-diketone and substituted terpyridine were studied. • Ternary complexes with substituted terpyridine showed blue-light excitability. • Ternary complexes were successfully loaded into the polystyrene nanoparticles. • Encapsulation of the complexes preserved their good photophysical features.

  1. 222-S LABORATORY FUME HOOD TESTING STUDY

    Energy Technology Data Exchange (ETDEWEB)

    RUELAS, B.H.

    2007-03-26

    The 222-S Laboratory contains 155 active fume hoods that are used to support analytical work with radioactive and/or toxic materials. The performance of a fume hood was brought into question after employees detected odors in the work area while mixing chemicals within the subject fume hood. Following the event, testing of the fume hood was conducted to assess the performance of the fume hood. Based on observations from the testing, it was deemed appropriate to conduct performance evaluations of other fume hoods within the laboratory.

  2. Treatment using oxaliplatin and S-1 adjuvant chemotherapy for pathological stage III gastric cancer: a multicenter phase II study (TOSA trial) protocol.

    Science.gov (United States)

    Namikawa, Tsutomu; Maeda, Hiromichi; Kitagawa, Hiroyuki; Oba, Koji; Tsuji, Akihito; Yoshikawa, Takaki; Kobayashi, Michiya; Hanazaki, Kazuhiro

    2018-02-13

    Recent studies demonstrated the efficacy of S-1-based adjuvant chemotherapy administered for six months after curative surgery for stage III gastric cancer; however, it is unproven whether this type of combination chemotherapy is more effective than the standard adjuvant chemotherapy of S-1 for one year. This multicenter phase II study evaluate the efficacy and safety of adjuvant chemotherapy using S-1 plus oxaliplatin followed by S-1 for up to one year for curatively resected stage III gastric cancer in patients aged over 20 years. Treatment initially comprises oral fluoropyrimidine S-1 (80 mg/m 2 ) administered twice daily for the first 2 weeks of a 3-week cycle. On day 1 of a second 3-week cycle, patients will receive 100 mg/m 2 of intravenous oxaliplatin followed by 80 mg/m 2 of S-1 (maximum 8 cycles). Then, the patients will receive 80 mg/m 2 of S-1 daily for 4 weeks, followed by 2 weeks of no chemotherapy. This 6-week cycle will be repeated during the first year after surgery. The primary endpoint is relapse-free survival for 3 years and secondary endpoints are safety, including the incidence of adverse events, and grading of neuropathy with each treatment cycle. The planned sample size of 75 patients is appropriate for this trial. The data will be analyzed on an intention-to-treat basis, assuming a two-sided test with a 5% level of significance. In contrast to previous trials, the current study involves administration of S-1 until one year after surgery in addition to prior S-1 plus oxaliplatin, and is the first study to evaluate the safety and efficacy of S-1 plus oxaliplatin followed by S-1 for up to one year in patients with curatively resected stage III gastric cancer. This trial is registered in the University Hospital Medical Information Network's Clinical Trials Registry (UMIN-CTR) registration number, R000029656  ( https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029656 ). Registered January 24, 2017.

  3. Design Study of Beijing XFEL Test Facility

    CERN Document Server

    Dai, J P

    2005-01-01

    As R&D of X-ray Free Electron Laser facility in China, the construction of Beijing XFEL Test Facility (BTF) has been proposed. And the start to end simulation of BTF was made with codes PARMELA, ELEGANT and TDA. This paper presents the motivation, the scheme and the simulation results of BTF.

  4. Power of an Adaptive Trial Design for Endovascular Stroke Studies: Simulations Using IMS (Interventional Management of Stroke) III Data.

    Science.gov (United States)

    Lansberg, Maarten G; Bhat, Ninad S; Yeatts, Sharon D; Palesch, Yuko Y; Broderick, Joseph P; Albers, Gregory W; Lai, Tze L; Lavori, Philip W

    2016-12-01

    Adaptive trial designs that allow enrichment of the study population through subgroup selection can increase the chance of a positive trial when there is a differential treatment effect among patient subgroups. The goal of this study is to illustrate the potential benefit of adaptive subgroup selection in endovascular stroke studies. We simulated the performance of a trial design with adaptive subgroup selection and compared it with that of a traditional design. Outcome data were based on 90-day modified Rankin Scale scores, observed in IMS III (Interventional Management of Stroke III), among patients with a vessel occlusion on baseline computed tomographic angiography (n=382). Patients were categorized based on 2 methods: (1) according to location of the arterial occlusive lesion and onset-to-randomization time and (2) according to onset-to-randomization time alone. The power to demonstrate a treatment benefit was based on 10 000 trial simulations for each design. The treatment effect was relatively homogeneous across categories when patients were categorized based on arterial occlusive lesion and time. Consequently, the adaptive design had similar power (47%) compared with the fixed trial design (45%). There was a differential treatment effect when patients were categorized based on time alone, resulting in greater power with the adaptive design (82%) than with the fixed design (57%). These simulations, based on real-world patient data, indicate that adaptive subgroup selection has merit in endovascular stroke trials as it substantially increases power when the treatment effect differs among subgroups in a predicted pattern. © 2016 American Heart Association, Inc.

  5. DECOVALEX III PROJECT. Thermal-Mechanical Modeling of the Yucca Mountain Project Drift Scale Test. Task 2B/2C Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Datta, Robin N. [Bechtel SAlC Company, Las Vegas (US)] (comp.)

    2005-02-15

    , ENRESA and NRC teams. All teams discretized the DST test area into two-dimensional vertical cross sections through the center of the heated drift and derived material properties suitable for their respective modeling approaches using the site testing data from Yucca Mountain project reports. The generally good agreement between simulated and measured temperature, displacements, and changes in air permeability shows that the numerical models and underlying conceptual models are adequate for simulating coupled THM processes at the DST. From the analyses and discussions presented, the following specific conclusions were drawn: i) A continuum model approach is adequate for simulating relevant coupled THM processes at the DST; ii) TM-induced rock deformations are generally well simulated using an elastic model, although some individual displacements appear to be captured using an elasto-plastic model; iii) The highest potential for inelastic deformation in the form of fracture shear slip occurs near the drift wall and in a zone of thermal stress decrease located more than 15 m above the heated drift and iv) Despite potential shear slip along fractures, fracture closure/opening caused by change in normal stress across fractures is the dominant mechanism for TM-induced changes in intrinsic fracture permeability, whereas fracture shear dilation appears to be less significant at the DST. This conclusion indicates that TM-induced changes in permeability at the DST, which are within one order of magnitude, tend to be reversible.

  6. Further Study of the Choice of Anchor Tests in Equating

    Science.gov (United States)

    Trierweiler, Tammy J.; Lewis, Charles; Smith, Robert L.

    2016-01-01

    In this study, we describe what factors influence the observed score correlation between an (external) anchor test and a total test. We show that the anchor to full-test observed score correlation is based on two components: the true score correlation between the anchor and total test, and the reliability of the anchor test. Findings using an…

  7. Structural, luminescence, thermodynamic and theoretical studies on mononuclear complexes of Eu(III) with pyridine monocarboxylate-N-oxides in aqueous solution

    Science.gov (United States)

    Dumpala, Rama Mohana Rao; Rawat, Neetika; Boda, Anil; Ali, Sk. Musharaf; Tomar, B. S.

    2018-02-01

    The mononuclear complexes formed by Eu(III) with three isomeric pyridine monocarboxylate-N-oxides namely picolinic acid-N-oxide (PANO), nicotinic acid-N-oxide (NANO) and isonicotinic acid-N-oxide (IANO) in aqueous solutions were studied by potentiometry, luminescence spectroscopy and isothermal titration calorimetry (ITC) to determine the speciation, coordination, luminescence properties and thermodynamic parameters of the complexes formed during the course of the reaction. More stable six membered chelate complexes with stoichiometry (MLi, i = 1-4) are formed by Eu(III) with PANO while non chelating ML and ML2 complexes are formed by NANO and IANO. The stability of Eu(III) complexes follow the order PANO > IANO > NANO. The ITC studies inferred an endothermic and innersphere complex formation of Eu(III)-PANO and Eu(III)-IANO whereas an exothermic and outer-sphere complex formation for Eu(III)-NANO. The luminescence life time data further supported the ITC results. Density functional theoretical calculations were carried out to optimize geometries of the complexes and to estimate the energies, structural parameters (bond distances, bond angles) and charges on individual atoms of the same. Theoretical approximations are found to be in good agreement with the experimental observations.

  8. Studies on the kinetics and equilibrium of the solvent extraction of chromium(III) from alkaline aqueous solutions of different composition in the system with Aliquat 336.

    Science.gov (United States)

    Wionczyk, Barbara; Cierpiszewski, Ryszard; Mól, Anna; Prochaska, Krystyna

    2011-12-30

    The kinetics and equilibrium of Cr(III) extraction with Aliquat 336 from the alkaline aqueous solutions containing anions of various complexing abilities and solvating properties, as: nitrates, or perchlorates, or sulphates, were studied and interpreted. Stoichiometry of Cr(III) complexes formed in the organic phases was also discussed. It was found that under the same conditions the yield and the rate of Cr(III) extraction as well as values of mass transfer coefficient increase in the following order of anions: perchloratesIII) in the systems with nitrates and/or perchlorates differs significantly from that one established for the extraction of Cr(III) from the alkaline aqueous solutions of sulphates. Experiments with the modified Lewis cell and analysis of the experimental data by mathematic models appeared that the studied extraction of Cr(III) occurs in the mixed diffusion-kinetic regime, irrespective of the kind of anions present in the aqueous phase. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. Ga(III) chelates of amphiphilic DOTA-based ligands: synthetic route and in vitro and in vivo studies

    Energy Technology Data Exchange (ETDEWEB)

    Fontes, Andre [Centro de Quimica, Campus de Gualtar, Universidade do Minho, 4710-057, Braga (Portugal); Prata, M. Isabel M. [IBILI, Faculdade de Medicina, Universidade de Coimbra, 3548, Coimbra (Portugal); Geraldes, Carlos F.G.C. [Departamento de Ciencias da Vida, Faculdade de Ciencias e Tecnologia, Universidade de Coimbra, 3001-401, Coimbra (Portugal); Centro de Neurociencias e Biologia Celular, Universidade de Coimbra, 3001-401, Coimbra (Portugal); Andre, Joao P., E-mail: jandre@quimica.uminho.p [Centro de Quimica, Campus de Gualtar, Universidade do Minho, 4710-057, Braga (Portugal)

    2011-04-15

    In this work, we report on a synthetic strategy using amphiphilic DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-based chelators bearing a variable-sized {alpha}-alkyl chain at one of the pendant acetate arms (from 6 to 14 carbon atoms), compatible with their covalent coupling to amine-bearing biomolecules. The amphiphilic behavior of the micelles-forming Ga(III) chelates (critical micellar concentration), their stability in blood serum and their lipophilicity (logP) were investigated. Biodistribution studies with the {sup 67}Ga-labeled chelates were performed in Wistar rats, which showed a predominant liver uptake with almost no traces of the radiochelates in the body after 24 h.

  10. Evaluation depth of the curve of Spee in class I, class II, and class III malocclusion: A cross sectional study

    Directory of Open Access Journals (Sweden)

    Sanjna Nayar

    2015-01-01

    Full Text Available Occlusal plane is an essential consideration when multiple long-span posterior restorations are designed. When restorations are added to an existing tooth arrangement characterized by rotated, tipped, or extruded teeth, excursive interferences may be incorporated, resulting in detrimental squeal. The curve of Spee, which exists in the ideal natural dentition, allows harmony to exist between the anterior tooth and condylar guidance. This curve exists in the sagittal plane and is the best viewed from a lateral aspect. It permits total posterior disclusion on mandibular protrusion, given proper anterior tooth guidance. It is unclear that whether the curve of Spee is a description of the occlusal surface of each arch separately or in maximal intercuspation. The purpose of this study was to examine the differences in the depth of curve of Spee between the class I, class II, class III and to investigate the relationship of depth of curve of Spee with over jet, over-bite.

  11. An Exploratory Study of Women in the Health Professions Schools. Volume III: Women in Osteopathic Medicine.

    Science.gov (United States)

    Urban and Rural Systems Associates, San Francisco, CA.

    As part of a larger study of the success and problems of women as applicants to and students in the schools of eight health professions, the study of osteopathic medicine involved interviews with administrators, faculty, and medical students. Its central purpose was to identify any characteristics of the profession--in its history, organization,…

  12. 77 FR 62518 - Proposed Collection; Comment Request: Recipient Epidemiology and Donor Evaluation Study-III (REDS...

    Science.gov (United States)

    2012-10-15

    ... research network has realized over the years while being responsive to changing research and clinical needs... timely fashion to potential blood safety threats such as West Nile Virus (WNV) in 2002 or Xenotropic... methods where appropriate to plan and implement time sensitive studies. Such studies that fall within the...

  13. Combustion Safety Simplified Test Protocol Field Study

    Energy Technology Data Exchange (ETDEWEB)

    Brand, L. [Gas Technology Inst., Des Plaines, IL (United States); Cautley, D. [Gas Technology Inst., Des Plaines, IL (United States); Bohac, D. [Gas Technology Inst., Des Plaines, IL (United States); Francisco, P. [Gas Technology Inst., Des Plaines, IL (United States); Shen, L. [Gas Technology Inst., Des Plaines, IL (United States); Gloss, S. [Gas Technology Inst., Des Plaines, IL (United States)

    2015-11-01

    Combustions safety is an important step in the process of upgrading homes for energy efficiency. There are several approaches used by field practitioners, but researchers have indicated that the test procedures in use are complex to implement and provide too many false positives. Field failures often mean that the house is not upgraded until after remediation or not at all, if not include in the program. In this report the PARR and NorthernSTAR DOE Building America Teams provide a simplified test procedure that is easier to implement and should produce fewer false positives. A survey of state weatherization agencies on combustion safety issues, details of a field data collection instrumentation package, summary of data collected over seven months, data analysis and results are included. The project team collected field data on 11 houses in 2015.

  14. Ligational behavior of clioquinol antifungal drug towards Ag(I), Hg(II), Cr(III) and Fe(III) metal ions: Synthesis, spectroscopic, thermal, morphological and antimicrobial studies

    Science.gov (United States)

    El-Megharbel, Samy M.; Refat, Moamen S.

    2015-04-01

    This article presents a synthesis, characterization, theoretical and biological (anti-bacterial, and anti-fugal) evaluation studies of Ag(I), Hg(II), Cr(III) and Fe(III) complexes of clioquinol (CQ) drug ligand. Structures of the titled complexes cited herein were discussed using elemental analyses and spectral measurements e.g., IR, 1H NMR, and electronic studies. The results confirmed the formation of the clioquinol complexes by three molar ratios (1:1) for Ag(I), (1:2) for Hg(II) and (1:3) for both Cr(III) and Fe(III) metal ions. The clioquinol reacts as a bidentate chelate bound to all respected metal ions through the oxygen and nitrogen of quinoline-8-ol. The metal(II) ions coordinated to clioquinol ligand through deprotonation of sbnd OH terminal group. Infrared and 1H NMR spectral data confirm that coordination is via the oxygen of phenolic group and nitrogen atom of quinoline moiety. The molar conductance measurements of the CQ complexes in DMSO correspond to be non-electrolyte nature. Thus, these complexes may be formulated as [Ag(CQ)(H2O)2] H2O, [Hg(CQ)2]ṡ2H2O, [Cr(CQ)3] and [Fe(CQ)3]H2O. The Coats-Redfern method, the kinetic thermodynamic parameters like activation energies (E∗), entropies (ΔS∗), enthalpies (ΔH∗), and Gibbs free energies (ΔG∗) of the thermal decomposition reactions have been deduced from thermogravimetric curves (TG) with helpful of differential thermo gravimetric (DTG) curves. The narrow size distribution in nano-scale range for the clioquinol complexes have been discussed using X-ray powder diffraction (XRD), scanning electron microscope (SEM), and X-ray energy dispersive spectrometer (EDX) analyzer.

  15. Pharmacokinetic sub-study in the SPIRIT III Randomized and Controlled Trial of XIENCE V everolimus eluting coronary stent system.

    Science.gov (United States)

    Wang, Qing; Pierson, Wesley; Sood, Poornima; Bol, Cornelis; Cannon, Louis; Gordon, Paul; Saucedo, Jorge; Sudhir, Krishnankutty

    2010-02-01

    Drug-eluting stents (DES) are widely used for treatment of coronary artery disease with benefit of reduced restenosis compared to bare metal stents. The XIENCE VEverolimus Eluting Coronary Stent System is a second-generation DES system for better deliverability while maintaining safety and efficacy profiles. The present pharmacokinetic sub-study from the SPIRIT III Randomized and Controlled Trial (RCT) was to evaluate systemic exposure of patients to everolimus and to further demonstrate safety following implantation of XIENCE Vstents with everolimus doses ranging from 53 to 181 microg. Drug concentrations in whole blood were determined at multiple time points using a validated analytical method with a limit of quantification of 0.1 ng/mL. Individual C(max) ranged from 0.17 to 2.40 ng/mL and occurred between 0.07 and 1.88 hours across all dose levels. Both mean and individual C(max) values were below the trough blood concentrations of everolimus (Certican) for inhibition of organ transplant rejection. The last time point at which drug concentrations could be quantified ranged from 12 to 168 hours postimplantation in individual patients. In most cases, the blood levels dropped below the limit of quantification after 72 hours. This study confirms that the XIENCE Vstent causes a limited and systemic exposure to everolimus. The presumed localized and efficient delivery of everolimus to target vessels coupled with limited and transient systemic drug exposure contributes to the safety and effectiveness of the XIENCE VEECSS in patients of SPIRIT III RCT for longer than 2 years.

  16. Recent regulatory experience of low-Btu coal gasification. Volume III. Supporting case studies

    Energy Technology Data Exchange (ETDEWEB)

    Ackerman, E.; Hart, D.; Lethi, M.; Park, W.; Rifkin, S.

    1980-02-01

    The MITRE Corporation conducted a five-month study for the Office of Resource Applications in the Department of Energy on the regulatory requirements of low-Btu coal gasification. During this study, MITRE interviewed representatives of five current low-Btu coal gasification projects and regulatory agencies in five states. From these interviews, MITRE has sought the experience of current low-Btu coal gasification users in order to recommend actions to improve the regulatory process. This report is the third of three volumes. It contains the results of interviews conducted for each of the case studies. Volume 1 of the report contains the analysis of the case studies and recommendations to potential industrial users of low-Btu coal gasification. Volume 2 contains recommendations to regulatory agencies.

  17. Eu(III) uptake on rectorite in the presence of humic acid: a macroscopic and spectroscopic study.

    Science.gov (United States)

    Chen, Changlun; Yang, Xin; Wei, Juan; Tan, Xiaoli; Wang, Xiangke

    2013-03-01

    This work contributed to the comprehension of humic acid (HA) effect on Eu(III) uptake to Na-rectorite by batch sorption experiments, model fitting, scanning electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and extended X-ray absorption fine structure (EXAFS) spectroscopy. At low pH, the presence of HA enhanced Eu(III) sorption on Na-rectorite, while reduced Eu(III) sorption at high pH. The experimental data of Eu(III) sorption in the absence and presence of HA were simulated by the diffuse-layer model well with the aid of FITEQL 3.2 software. The basal spacing of rectorite became large after Eu(III) and HA sorption on Na-rectorite. Some of Eu(III) ions and HA might be intercalated into the interlayer space of Na-rectorite. EXAFS analysis showed that the R(Eu-O) (the bond distance of Eu and O in the first shell of Eu) and N values (coordination number) of Eu(III)-HA-rectorite system were smaller than those of Eu(III)-rectorite system. Copyright © 2012 Elsevier Inc. All rights reserved.

  18. Assessing Old Order Amish outpatients with the MCMI-III.

    Science.gov (United States)

    Knabb, Joshua J; Vogt, Ronald G

    2011-05-01

    In this study, we examined Millon Clinical Multiaxial Inventory-III (MCMI-III; Millon, 2009) characteristics in an Old Order Amish outpatient sample (n = 166), with a comparison group of Old Order Amish who were not receiving mental health treatment at the time of testing (n = 80). We also graphically compared the 2 Amish groups to a non-Amish psychiatric sample in the literature. Consistent with our hypotheses, the Old Order Amish outpatients scored significantly higher than the Old Order Amish comparison group on the majority of MCMI-III scales, with mostly medium effect sizes, suggesting that the MCMI-III is a useful personality instrument in discriminating between Old Order Amish clinical and nonclinical groups. In addition, the Amish outpatients scored similar to a non-Amish psychiatric sample in the literature on most personality scales. Future MCMI-III studies with the Amish are needed to replicate and generalize our findings.

  19. SAMICS validation. SAMICS support study: Phase III. Final report, Jet Propulsion Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    1979-03-01

    The purpose of SAMICS is to provide a consistent basis for estimating solar cell array costs and comparing production technology costs. The user of SAMICS provides detailed process information for calculating direct costs. To these are added indirect and overhead expenses. Although thorough documentation of direct processes requires a significant initial effort, the process gives SAMICS its primary strength. A complete accounting of direct process resource requirements establishes an audit trail that will help to monitor the realism of assumptions before production and to later identify variations from forecasted operating parameters after production begins. The purpose for this review were the following: (a) to test the computational validity of the computer model by comparison with preliminary hand calculations based on conventional cost estimating techniques; (b) to review and improve the accuracy of the cost relationships being used by the model; and (c) to provide an independent verification to users of the model's value in decision making for allocation of research and development funds and for investment in manufacturing capacity. The conclusion is that the SAMICS model is a flexible, accurate, and useful tool for managerial decision making. The comparison of model results with calculations shows close correlation. This report provides the basis for conclusions. It also contains recommendations for increasing the usefulness of SAMICS. (WHK)

  20. The Impact of Self-Study on GRE Test Performance.

    Science.gov (United States)

    Swinton, Spencer S.; Powers, Donald E.

    The study reported here was intended to "round out" the Graduate Record Examinations (GRE) Board's continuing study of special test preparation for the GRE General Test by providing information that was previously unavailable on the effects of one kind of special test preparation--self-test-familiarization for the verbal and quantitative…

  1. Prevalence of celiac disease and related antibodies in patients diagnosed with irritable bowel syndrome according to the Rome III criteria. A case-control study.

    Science.gov (United States)

    Sánchez-Vargas, L A; Thomas-Dupont, P; Torres-Aguilera, M; Azamar-Jacome, A A; Ramírez-Ceervanes, K L; Aedo-Garcés, M R; Meixueiro-Daza, A; Roesch-Dietlen, F; Grube-Pagola, P; Vivanco-Cid, H; Remes-Troche, J M

    2016-07-01

    The cost-effectiveness for screening for celiac disease (CD) in patients with irritable bowel syndrome (IBS), specifically in the diarrhea (IBS-D) subtype, is beneficial if the prevalence is >1%. However, recent studies have shown controversial results. In this large case-control study, our aim was to determine the prevalence of CD and a panel of related antibodies in patients diagnosed with IBS. Four hundred IBS patients (Rome III) and 400 asymptomatic healthy controls were prospectively evaluated using antihuman tissue transglutaminase (h-tTG IgA) and deamidated gliadin peptide antibodies (DGP II IgA and DGP II IgG). Duodenal biopsy was performed on the patients that were positive for the h-tTG IgA and/or DGP II IgG antibodies. The mean age of the population was 44.47 ± 18.01 years and 335 (82%) of the subjects were women. Twenty-one patients and six controls had at least one positive test for CD (5.25% VS 1.5%, p = 0.003, OR 3.63 [95% CI 1.4-9.11]). Eighteen patients were positive for h-tTG and/or DGP-II IgG. Histologic confirmation of CD was 2.5% in the IBS patients vs 0.5% in the controls (p = 0.04, OR 5.21). The IBS-D subtype had the highest prevalence for serological positivity (12.7%). Up to 5.2% of the patients with IBS according to the Rome III criteria were positive for at least one of the CD-related antibodies and 2.5% had biopsy-confirmed CD. Therefore, in our population, screening for CD in subjects with IBS appears to be a reasonable strategy, especially in the IBS-D subgroup. © 2016 John Wiley & Sons Ltd.

  2. The specific sorption of Np(V) on the corundum (α-Al2O3) surface in the presence of trivalent lanthanides Eu(III) and Gd(III): A batch sorption and XAS study.

    Science.gov (United States)

    Virtanen, S; Bok, F; Ikeda-Ohno, A; Rossberg, A; Lützenkirchen, J; Rabung, T; Lehto, J; Huittinen, N

    2016-12-01

    The sorption of pentavalent neptunium, Np(V), on corundum (α-Al2O3) was investigated in the absence and presence of trivalent europium or gadolinium as a competing element under CO2-free conditions. The objective of this study was to investigate how a trivalent metal ion with a higher charge than that of the neptunyl(V) ion would affect the sorption of Np(V) when allowed to adsorb on the mineral surface before the addition of Np(V). Batch sorption experiments conducted as a function of pH (pH-edges) and as a function of Np(V) concentration (isotherms) in the absence and presence of 1×10(-5)M Eu(III) showed no sign of Eu being able to block Np sorption sites. Surface complexation modelling using the diffuse double layer model was applied to the batch data to obtain surface complexation constants for the formed Np(V) complexes on corundum. To account for potential changes occurring in the coordination environment of the neptunium ion in the presence of a trivalent lanthanide, X-ray absorption spectroscopy (XAS) measurements were carried out on the samples containing only Np(V) and Np(V)+Gd(III). The results reveal the presence of a bidentate Np(V) edge-sharing complex on the corundum surface in the absence of Gd(III), while the coordination environment of Np(V) on the corundum surface could be changed when Gd(III) is added to the sample before the sorption of Np(V). Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Physical Characteristics. Resource Unit III, Grade 6. Providence Social Studies Curriculum Project.

    Science.gov (United States)

    Providence Public Schools, RI.

    GRADES OR AGES: Grade 6. SUBJECT MATTER: Social studies; physical geography of Latin America and Africa. ORGANIZATION AND PHYSICAL APPEARANCE: The major portion of the guide, which develops the unit, is laid out in three columns, one each for topics, activities, and materials. Other sections are in list form. The guide is mimeographed and…

  4. Mortality of iron foundry workers. III. Lung cancer case-control study.

    Science.gov (United States)

    Andjelkovich, D A; Shy, C M; Brown, M H; Janszen, D B; Levine, R J; Richardson, R B

    1994-12-01

    A nested case-control study was undertaken to identify the determinants of lung cancer mortality in a cohort of 8147 foundry men among whom an excess of lung cancer deaths was previously observed. The present study consisted of all lung cancer deaths (N = 220) that occurred within this cohort between 1950 and 1989. both living and dead controls, matched on race and attained age, were selected in the ratio of 10:1 (N = 2200) by means of the incidence density sampling procedure. All cases and two controls per case, randomly selected from each case's 10 controls, were included in a smoking history survey. Basic smoking history information was obtained for about 71% of these study subjects. For the purpose of this study, formaldehyde exposure levels were categorized as high, medium, low, and none. Airborne silica exposure was categorized only as high, medium, and low levels, because all foundry workers were known to be exposed to silica. Conditional logistic regression analyses indicated that cigarette smoking was a strong predictor of lung cancer mortality in this cohort. Neither exposure to formaldehyde nor silica exposure level, nor employment in any of the six major work areas within the foundry, showed an association with lung cancer.

  5. Studies on Opilioacarida (Arachnida) III. Opilioacarus platensis Silvestri, and Adenacarus arabicus (With)

    NARCIS (Netherlands)

    Hammen, van der L.

    1969-01-01

    The present paper deals with two species of Opilioacarida, viz., Opilioacarus platensis Silvestri (1905) and Adenacarus arabicus (With, 1904). Both are already mentioned in the first part of my series of studies on Opilioacarida (Van der Hammen, 1966) ; at that time I had seen only their original

  6. Vortices in dam reservoir: A case study of Karun III dam

    Indian Academy of Sciences (India)

    The results were then processed to plot the contour lines of the plane velocities and study the effect of vortex formation on the flow condition in the reservoir. ... Department of Civil and Environmental Engineering, Amirkabir University of Technology, Tehran P.O. Box: 15914, Iran; Department of Engineering, Hakim Sabzevari ...

  7. Combustion Safety Simplified Test Protocol Field Study

    Energy Technology Data Exchange (ETDEWEB)

    Brand, L [Gas Technology Inst., Des Plaines, IL (United States); Cautley, D. [Gas Technology Inst., Des Plaines, IL (United States); Bohac, D. [Gas Technology Inst., Des Plaines, IL (United States); Francisco, P. [Gas Technology Inst., Des Plaines, IL (United States); Shen, L. [Gas Technology Inst., Des Plaines, IL (United States); Gloss, S. [Gas Technology Inst., Des Plaines, IL (United States)

    2015-11-05

    "9Combustions safety is an important step in the process of upgrading homes for energy efficiency. There are several approaches used by field practitioners, but researchers have indicated that the test procedures in use are complex to implement and provide too many false positives. Field failures often mean that the house is not upgraded until after remediation or not at all, if not include in the program. In this report the PARR and NorthernSTAR DOE Building America Teams provide a simplified test procedure that is easier to implement and should produce fewer false positives. A survey of state weatherization agencies on combustion safety issues, details of a field data collection instrumentation package, summary of data collected over seven months, data analysis and results are included. The project provides several key results. State weatherization agencies do not generally track combustion safety failures, the data from those that do suggest that there is little actual evidence that combustion safety failures due to spillage from non-dryer exhaust are common and that only a very small number of homes are subject to the failures. The project team collected field data on 11 houses in 2015. Of these homes, two houses that demonstrated prolonged and excessive spillage were also the only two with venting systems out of compliance with the National Fuel Gas Code. The remaining homes experienced spillage that only occasionally extended beyond the first minute of operation. Combustion zone depressurization, outdoor temperature, and operation of individual fans all provide statistically significant predictors of spillage.

  8. RF test benches for electron cloud studies

    CERN Document Server

    Iriso-Ariz, U; Laurent, Jean Michel; Mostacci, A

    2002-01-01

    In the framework of the CERN program on the electron cloud effects in existing and future accelerators, a coaxial multipacting test stand was built. It consists of a 100 mm diameter vacuum chamber forming the outer conductor and 6 wires cage-aerial-type as the inner conductor. In order to simulate the bunched beam, this test stand is submitted to short RF pulses. The available field strength in a travelling wave mode allows to trigger electron multipacting in as received or baked stainless steel surfaces, but not in chambers treated to reduce the secondary emission yield. Thus a number of upgrades in the bench set-up have been pursued, mainly in two directions. The first one is a general improvement on mismatches and losses. Second, instead of dumping the pulsed power into a load, it is re-circulated in a multiple frequency ring resonator. For this purpose, we designed a directional coupler with several kV DC isolation, very low transmission losses and a four octave bandwidth. In this paper, we give an overvi...

  9. Molecular structure of tetraaqua adenosine 5'-triphosphate aluminium(III) complex: A study involving Raman spectroscopy, theoretical DFT and potentiometry

    Science.gov (United States)

    Tenório, Thaís; Silva, Andréa M.; Ramos, Joanna Maria; Buarque, Camilla D.; Felcman, Judith

    2013-03-01

    The Alzheimer's disease is one of the most common neurodegenerative diseases that affect elderly population, due to the formation of β-amyloid protein aggregate and several symptoms, especially progressive cognitive decline. The result is a decrease in capture of glucose by cells leading to obliteration, meddling in the Krebs cycle, the principal biochemical route to the energy production leading to a decline in the levels of adenosine 5'-triphosphate. Aluminium(III) is connected to Alzheimer's and its ion provides raise fluidity of the plasma membrane, decrease cell viability and aggregation of amyloid plaques. Studies reveal that AlATP complex promotes the formation of reactive fibrils of β-amyloid protein and independent amyloidogenic peptides, suggesting the action of the complex as a chaperone in the role pathogenic process. In this research, one of complexes formed by Al(III) and adenosine 5'-triphosphate in aqueous solution is analyzed by potentiometry, Raman spectroscopy and ab initio calculations. The value of the log KAlATP found was 9.21 ± 0.01 and adenosine 5'-triphosphate should act as a bidentate ligand in the complex. Raman spectroscopy and potentiometry indicate that donor atoms are the oxygen of the phosphate β and the oxygen of the phosphate γ, the terminal phosphates. Computational calculations using Density Functional Theory, with hybrid functions B3LYP and 6-311++G(d,p) basis set regarding water solvent effects, have confirmed the results. Frontier molecular orbitals, electrostatic potential contour surface, electrostatic potential mapped and Mulliken charges of the title molecule were also investigated.

  10. Molecular structure of tetraaqua adenosine 5'-triphosphate aluminium(III) complex: a study involving Raman spectroscopy, theoretical DFT and potentiometry.

    Science.gov (United States)

    Tenório, Thaís; Silva, Andréa M; Ramos, Joanna Maria; Buarque, Camilla D; Felcman, Judith

    2013-03-15

    The Alzheimer's disease is one of the most common neurodegenerative diseases that affect elderly population, due to the formation of β-amyloid protein aggregate and several symptoms, especially progressive cognitive decline. The result is a decrease in capture of glucose by cells leading to obliteration, meddling in the Krebs cycle, the principal biochemical route to the energy production leading to a decline in the levels of adenosine 5'-triphosphate. Aluminium(III) is connected to Alzheimer's and its ion provides raise fluidity of the plasma membrane, decrease cell viability and aggregation of amyloid plaques. Studies reveal that AlATP complex promotes the formation of reactive fibrils of β-amyloid protein and independent amyloidogenic peptides, suggesting the action of the complex as a chaperone in the role pathogenic process. In this research, one of complexes formed by Al(III) and adenosine 5'-triphosphate in aqueous solution is analyzed by potentiometry, Raman spectroscopy and ab initio calculations. The value of the logK(AlATP) found was 9.21±0.01 and adenosine 5'-triphosphate should act as a bidentate ligand in the complex. Raman spectroscopy and potentiometry indicate that donor atoms are the oxygen of the phosphate β and the oxygen of the phosphate γ, the terminal phosphates. Computational calculations using Density Functional Theory, with hybrid functions B3LYP and 6-311++G(d,p) basis set regarding water solvent effects, have confirmed the results. Frontier molecular orbitals, electrostatic potential contour surface, electrostatic potential mapped and Mulliken charges of the title molecule were also investigated. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. Thermodynamic study on the complexation of Trivalent actinide and lanthanide cation by N-donor ligands in homogeneous conditions; Etude thermodynamique de la complexation des ions actinide (III) et lanthanide (III) par des ligands polyazotes en milieu homogene

    Energy Technology Data Exchange (ETDEWEB)

    Miguirditchian, M

    2004-07-01

    Polydentate N-donor ligands, alone or combined with a synergic acid, may selectively extract minor actinides(III) from lanthanide(III) ions, allowing to develop separation processes of long-live radioelements. The aim of the researches carried out during this thesis was to better understand the chemical mechanisms of the complexation of f-elements by Adptz, a tridentate N-donor ligand, in homogeneous conditions. A thermodynamic approach was retained in order to estimate, from an energetic point of view, the influence of the different contributions to the reaction, and to acquire a complete set of thermodynamic data on this reaction. First, the influence of the nature of the cation on the thermodynamics was considered. The stability constants of the 1/1 complexes were systematically determined by UV-visible spectrophotometry for every lanthanide ion (except promethium) and for yttrium in a mixed solvent methanol/water in volume proportions 75/25%. The thermodynamic parameters ({delta}H{sup 0} {delta}{sup S}) of complexation were estimated by the van't Hoff method and by micro-calorimetry. The trends of the variations across the lanthanide series are compared with similar studies. The same methods were applied to the study of three actinide(III) cations: plutonium, americium and curium. The comparison of these values with those obtained for the lanthanides highlights the increase of stability of these complexes by a factor of 20 in favor of the actinide cations. This gap is explained by a more exothermic reaction and is associated, in the data interpretation, to a higher covalency of the actinide(III)-nitrogen bond. Then, the influence of the change of solvent composition on the thermodynamic of complexation was studied. The thermodynamic parameters of the complexation of europium(III) by Adptz were determined for several fractions of methanol. The stability of the complex formed increases with the percentage of methanol in the mixed solvent, owing to an

  12. Operational performance of the ETH-hybrid III drive system - at the test stand and in the vehicle; Betriebsverhalten des ETH-Hybrid III Antriebes - Auf dem dynamischen Pruefstand und im Fahrzeug

    Energy Technology Data Exchange (ETDEWEB)

    Dietrich, P.; Eberle, M.K.

    1999-07-01

    The position and the way of operation of the ETH hybrid III drive system in an Otto engine, an electric motor, a flywheel and an infinitely variable wide-range transmission are presented. The consumption values for gasoline and electric power are shown for constant drive and in city cycles. The achievable conservation of 40% at gasoline operation is not limited to one cycle and shows the robustness of this measure to improve partial load operation. The sensitiveness towards the evaluated current generation is shown by means of the autarkic charge operation. (orig.) [German] Es wird die Anordnung und die Betriebsweise des ETH-Hybrid III Antriebes mit einem Ottomotor, einem Elektromotor, einem Schwungrad und einem stufenlosen Weitbereichsgetriebe dargestellt. Es werden die Verbrauchswerte bei Konstantfahrt und in Stadtzyklen sowohl fuer Benzin und Strom aufgezeigt. Die erzielbaren 40% Verbrauchseinsparung im Benzinbetrieb ist nicht nur auf einen Zyklus beschraenkt und zeigt die Robustheit dieser Teillastverbesserungsmassnahme auf. Anhand des autarken Ladebetriebes wird die Sensitivitaet gegenueber der betrachteten Stromherstellung aufgezeigt. (orig.)

  13. Preparation and Characterization of Cerium (III Doped Captopril Nanoparticles and Study of their Photoluminescence Properties

    Directory of Open Access Journals (Sweden)

    Ghamami Shahriar

    2016-01-01

    Full Text Available In this research Ce3+ doped Captopril nanoparticles (Ce3+ doped CAP-NP were prepared by a cold welding process and have been studied. Captopril may be applied in the treatment of hypertension and some types of congestive heart failure and for preventing kidney failure due to high blood pressure and diabetes. CAP-NP was synthesized by a cold welding process. The cerium nitrate was added at a ratio of 10% and the optical properties have been studied by photoluminescence (PL. The synthesized compounds were characterized by Fourier transform infrared spectroscopy. The size of CAP-NP was calculated by X-ray diffraction (XRD. The size of CAP-NP was in the range of 50 nm. Morphology of surface of synthesized nanoparticles was studied by scanning electron microscopy (SEM. Finally the luminescence properties of undoped and doped CAP-NP were compared. PL spectra from undoped CAP-NP show a strong pack in the range of 546 nm after doped cerium ion into the captopril appeared two bands at 680 and 357 nm, which is ascribed to the well-known 5d–4f emission band of the cerium.

  14. Chemical process based reconstruction of exposures for an epidemiological study. III. Analysis of industrial hygiene samples.

    Science.gov (United States)

    Hall, Thomas A; Esmen, Nurtan A; Jones, Elizabeth P; Basara, Heather; Phillips, Margaret L; Marsh, Gary M; Youk, Ada O; Buchanich, Jeanine M; Leonard, Robin C

    2007-03-20

    As part of an historical cohort study to investigate the mortality experience of industrial workers exposed to chloroprene (beta-CD) and other substances, all available industrial hygiene exposure monitoring data were collected and summarized. From discussions with on-site industrial hygiene personnel, it was apparent that these data were not collected for epidemiological purposes and, therefore, their use in characterization of exposures was problematic as the data mostly pertained to samples collected to investigate the performance of specific tasks. These data were, however, informative for validating the exposure modeling process used to estimate historical exposures. The data summarized below clearly indicate that exposures to beta-CD were lowered across the time period of this study. Typically, the exposures recorded were less than the occupational exposure limits of the periods in which the exposures were recorded. Additionally, exposure measurements recorded in the recent past do not represent the exposure actually experienced by the worker as a strict personal protective equipment use program has been in place for the facilities studied since the mid-1980s.

  15. Multidisciplinary study of Wyoming test sites

    Science.gov (United States)

    Houston, R. S. (Principal Investigator); Marrs, R. W.

    1973-01-01

    The author has identified the following significant results. Comparisons between ERTS-1 and EREP 70 mm images revealed that the EREP S-190A imagery is superior to ERTS-1 in spacial resolution but lacks tonal fidelity. However, tests of the S-192 screening film indicate that it will provide the necessary tonal fidelity for color additive work. No resolution comparisons were made with the S-192 imagery because the screening film, the only S-192 data currently available, does not represent an optimum quality product. Correlative ground truth data and aircraft imagery have been gathered for each of the EREP data passes. These data will not only serve as a primary means of calibrating EREP data and checking interpretations, but also aid in making decisions about optimum band combinations for S-190A and S-192.

  16. Conversion to eslicarbazepine acetate monotherapy: A pooled analysis of 2 phase III studies.

    Science.gov (United States)

    Sperling, Michael R; French, Jacqueline; Jacobson, Mercedes P; Pazdera, Ladislav; Gough, Mallory; Cheng, Hailong; Grinnell, Todd; Blum, David

    2016-03-22

    To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy. This post hoc pooled analysis of 2 randomized double-blind studies (093-045 and -046) included adults with partial-onset seizures medically uncontrolled by 1 or 2 antiepileptic drugs (AEDs). Following the baseline period (8 weeks), eligible patients were randomized 2:1 to receive ESL 1,600 mg or 1,200 mg once daily for 18 weeks; the primary endpoint was study exit by meeting predefined exit criteria (signifying worsening seizure control). In each study, treatment was considered effective if the upper 95% confidence limit for exit rate was lower than the historical control threshold (65.3%). Pooled exit rates were as follows: ESL 1,600 mg = 20.6% (95% confidence interval: 15.6%-26.8%); ESL 1,200 mg = 30.8% (23.0%-40.5%). Use of 2 baseline AEDs or rescue medication, US location, epilepsy duration ≥20 years, and higher maximum baseline seizure frequency were associated with higher exit risks. Median percent reductions in standardized seizure frequency between baseline and the 18-week double-blind period were as follows: ESL 1,600 mg = 43.2%; ESL 1,200 mg = 35.7%; baseline carbamazepine use was associated with smaller reductions. Safety profiles were similar between ESL doses. Exit rates for ESL monotherapy (1,600 mg and 1,200 mg once daily) were lower than the historical control threshold, irrespective of baseline AED use and region, with no additional safety concerns identified. Clinical factors and location clearly influence treatment responses in conversion-to-monotherapy trials. This pooled analysis provides Class IV evidence that for adults with medically uncontrolled partial-onset seizures, ESL monotherapy is well tolerated and effective. © 2016 American Academy of Neurology.

  17. A Study of Future Communications Concepts and Technologies for the National Airspace System-Part III

    Science.gov (United States)

    Ponchak, Denise S.; Apaza, Rafael D.; Wichgersm Joel M.; Haynes, Brian; Roy, Aloke

    2014-01-01

    The National Aeronautics and Space Administration (NASA) Glenn Research Center (GRC) is investigating current and anticipated wireless communications concepts and technologies that the National Airspace System (NAS) may need in the next 50 years. NASA has awarded three NASA Research Announcements (NAR) studies with the objective to determine the most promising candidate technologies for air-to-air and air-to-ground data exchange and analyze their suitability in a post-NextGen NAS environment. This paper will present progress made in the studies and describe the communications challenges and opportunities that have been identified as part of the study. NASA's NextGen Concepts and Technology Development (CTD) Project integrates solutions for a safe, efficient and high-capacity airspace system through joint research efforts and partnerships with other government agencies. The CTD Project is one of two within NASA's Airspace Systems Program and is managed by the NASA Ames Research Center. Research within the CTD Project is in support the 2011 NASA Strategic Plan Sub-Goal 4.1: Develop innovative solutions and advanced technologies, through a balanced research portfolio, to improve current and future air transportation. The focus of CTD is on developing capabilities in traffic flow management, dynamic airspace configuration, separation assurance, super density operations and airport surface operations. Important to its research is the development of human/automation information requirements and decisionmaking guidelines for human-human and human-machine airportal decision-making. Airborne separation, oceanic intrail climb/descent and interval management applications depend on location and intent information of surrounding aircraft. ADS-B has been proposed to provide the information exchange, but other candidates such as satellite-based receivers, broadband or airborne internet, and cellular communications are possible candidate's.

  18. The aminoterminal propeptide of type III procollagen. Studies on physiology and pathophysiology

    DEFF Research Database (Denmark)

    Jensen, L T

    1997-01-01

    receiving growth hormone therapy. We conclude: 1) That, for our purpose, the best method of determining PIIINP is the PIIINP RIA, owing to the profile of the substances determined. It was possible to improve the quality of the tracer and to increase sensitivity by changing the assay procedure. 2......) That porcine PIIINP is similar to human PIIINP, therefore the human assay is suitable for studies in pigs. 3) That PIIINP most likely escapes from the extracellular space by bulk flow, similar to that of albumin. That the major part of the PIIINP synthesised is drained via the lymphatics. That intact PIIINP...

  19. Moessbauer effect study of iron(III)-inidazolidine nitroxyl-free radical ligand complex

    Energy Technology Data Exchange (ETDEWEB)

    Mulaba, A. [Technikon Witwatersrand, Metallurgy Department (South Africa); Kiremire, E. [University of the Witwatersrand, Chemistry Department (South Africa); Pollak, H. [University of the Witwatersrand, Physics Department (South Africa); Boeyens, J. [University of the Witwatersrand, Chemistry Department (South Africa)

    1999-09-15

    A new complex, [Fe(acac)L{sub 2}], bearing inidazolidine nitroxyl-free radical ligand (L{sup -}) was recently synthesised for biological studies. It proved to be biologically active against African sleeping sickness, plasmodium falciparum (malaria), leishmaniasis and chaga disease causative agents. Three ESR well resolved peaks indicated the presence of a free (unpaired) and chemically active electron in the complex. The structural complex ferric iron was found at the centre of two electric gradient whose the biggest is suggested to be initiated by the unpaired charge. No distinction between different cis isomers could be made.

  20. WISC-III e WAIS-III na avaliação da inteligência de cegos WISC-III/WAIS-III en ciegos WISC-III and WAIS-III in intellectual assessment of blind people

    Directory of Open Access Journals (Sweden)

    Elizabeth do Nascimento

    2007-12-01

    Full Text Available Diante da escassez de pesquisas nacionais e de testes psicológicos destinados a avaliar pessoas cegas, desenvolveu-se um estudo psicométrico com as escalas verbais dos testes WISC-III e WAIS-III. Após as adaptações de alguns estímulos e das instruções, os testes foram aplicados em crianças (N = 120 e adultos (N = 52 residentes em Belo Horizonte. Os resultados indicaram que as escalas verbais modificadas apresentam uma boa consistência interna (alfa> 0,80. Além disso, a investigação da validade fatorial identifica a presença clara de apenas um componente. Este componente explica 81% e 64% para o WISC-III e WAIS-III, respectivamente. Conclui-se que as adaptações a que se procedeu não afetaram a estrutura fatorial das escalas. Deste modo, os profissionais poderão utilizar as escalas modificadas para avaliar a inteligência de pessoas cegas.Frente a la escasez de investigaciones nacionales asi como la ausencia de tests psicológicos que evaluen personas ciegas, se ha desarrollado un estudio psicometrico com la escalas verbales del WISC-III y WAIS-III. Posteriormente a las adaptaciones de algunos estímulos y de las instrucciones, las escalas fueron aplicadas a una muestra de niños (n=120 y de adultos (n=52 residentes en la ciudad de Belo Horizonte-Brasil. Los resultados indican que las escalas verbales modificadas presentan una alta fiabilidad (alpha >0,80 asi como la presencia clara de un unico componente responsable por 81% y 64% de la variancia del WIC-III e WAIS-III respectivamente. Se ha concluido que las modificaciones efectuadas no han comprometido la estructura factorial de las escalas verbales. Por tanto, los profesionales psicólogos pueden utilizar las escalas modificadas para la evaluación de la inteligencia de personas portadoras de ceguera.Owing to the almost lack of a national research on psychological testing for the evaluation of blind people, a psychometric study has been developed with the WISC-III and WAIS-III

  1. ESR study of photodegradation of N-alkylamide containing iron(III) chloride

    Energy Technology Data Exchange (ETDEWEB)

    Kurita, Y.; Yokoyama, Y.; Fujii, Y. (Yokohama National Univ. (Japan). Faculty of Engineering); Shirokaze, J.

    1982-07-01

    Photodegradation mechanism of N-alkylamides (N-methylformamide, N-methylacetamide, N-propylpropanamide, and N-propylhexanamide) containing FeCl/sub 3/ was studied mainly by means of ESR spectroscopy. Examination of IR and UV spectra revealed that amides coordinate to FeCl/sub 3/ through the oxygen atoms. A charge-transfer absorption band was observed (lambda sub(max) 312nm, epsilon = 4.3 x 10/sup 3/) in the case of N-propylpropanamide-FeCl/sub 3/. An ESR study determined structures of radicals generated by photo-irradiation of various kinds of amides containing FeCl/sub 3/. UV irradiation gave rise to a rupture of the amide linkage to produce an acyl radical. The acyl radical was decarbonylated to become an alkyl radical (or hydrogen atom in the case of N-methylformamide) by irradiation of visible light. When the alkyl radical was small (in such cases as N- methylformamide, N-methylacetamide, and N-propylpropanamide), an extraction of hydrogen atom from other molecules occurred during annealing, and two kinds of other radicals were produced : a radical bearing an unpaired electron on a carbon atom adjacent to a carbonyl group, and an iminyl radical. Detection of the iminyl radical confirmed that a generation of imine was accompanied with the formation of acyl radical at the initial process of UV irradiation.

  2. PIO I-II tendencies case study. Part 1. Mathematical modeling

    Directory of Open Access Journals (Sweden)

    Adrian TOADER

    2010-03-01

    Full Text Available In the paper, a study is performed from the perspective of giving a method to reduce the conservatism of the well known PIO (Pilot-Induced Oscillation criteria in predicting the susceptibility of an aircraft to this very harmful phenomenon. There are three interacting components of a PIO – the pilot, the vehicle, and the trigger (in fact, the hazard. The study, conceived in two parts, aims to underline the importance of human pilot model involved in analysis. In this first part, it is shown, following classical sources, how the LQG theory of control and estimation is used to obtain a complex model of human pilot. The approach is based on the argument, experimentally proved, that the human behaves “optimally” in some sense, subject to his inherent psychophysical limitations. The validation of such model is accomplished based on the experimental model of a VTOL-type aircraft. Then, the procedure of inserting typical saturation nonlinearities in the open loop transfer function is presented. A second part of the paper will illustrate PIO tendencies evaluation by means of a grapho-analytic method.

  3. Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer

    Directory of Open Access Journals (Sweden)

    Huijts Charlotte M

    2011-11-01

    Full Text Available Abstract Background For patients with metastatic renal cell cancer (mRCC who progressed on vascular endothelial growth factor (VEGF receptor tyrosine kinase inhibitor therapy, the orally administered mammalian target of rapamycin (mTOR inhibitor everolimus has been shown to prolong progression free survival. Intriguingly, inhibition of mTOR also promotes expansion of immunosuppressive regulatory T cells (Tregs that can inhibit anti-tumor immune responses in a clinically relevant way in various tumor types including RCC. This study intends to investigate whether the antitumor efficacy of everolimus can be increased by preventing the detrimental everolimus induced expansion of Tregs using a metronomic schedule of cyclophosphamide. Methods/design This phase I-II trial is a national multi-center study of different doses and schedules of low-dose oral cyclophosphamide in combination with a fixed dose of everolimus in patients with mRCC not amenable to or progressive after a VEGF-receptor tyrosine kinase inhibitor containing treatment regimen. In the phase I part of the study the optimal Treg-depleting dose and schedule of metronomic oral cyclophosphamide when given in combination with everolimus will be determined. In the phase II part of the study we will evaluate whether the percentage of patients progression free at 4 months of everolimus treatment can be increased from 50% to 70% by adding metronomic cyclophosphamide (in the dose and schedule determined in the phase I part. In addition to efficacy, we will perform extensive immune monitoring with a focus on the number, phenotype and function of Tregs, evaluate the safety and feasibility of the combination of everolimus and cyclophosphamide, perform monitoring of selected angiogenesis parameters and analyze everolimus and cyclophosphamide drug levels. Discussion This phase I-II study is designed to determine whether metronomic cyclophosphamide can be used to counter the mTOR inhibitor everolimus

  4. MITR-III: Upgrade and relicensing studies for the MIT Research Reactor. Second annual report

    Energy Technology Data Exchange (ETDEWEB)

    Trosman, H.G. [ed.; Lanning, D.D.; Harling, O.K.

    1994-08-01

    The current operating license of the MIT research reactor will expire on May 7, 1996 or possibly a few years later if the US Nuclear Regulatory Commission agrees that the license period can start with the date of initial reactor operation. Driven by the imminent expiration of the operating license, a team of nuclear engineering staff and students have begun a study of the future options for the MIT Research Reactor. These options have included the range from a major rebuilding of the reactor to its decommissioning. This document reports the results of a two year intensive activity which has been supported by a $148,000 grant from the USDOE contract Number DEFG0293ER75859, approximately $100,000 of internal MIT funds and Nuclear Engineering Department graduate student fellowships as well as assistance from international visiting scientists and engineers.

  5. Comparative study of MEBES III and CORE 2564 performance in a manufacturing environment

    Science.gov (United States)

    Felmlee, Theron L.; Raghavan, Vijaya N.

    1993-06-01

    Many of the same considerations that were instrumental in providing the state-of-the-art e- beam process were implemented in the recent installation of the ETEC CORE 2564 laser-beam mask/reticle lithography system and the associated process setup. The possession of two high- performance mask/reticle production processes created a need to perform a comparative investigation of the manufacturing performance of the two systems and their associated processes. This study points out some of the manufacturing strengths and weaknesses of these two distinctly different mask/reticle production processes. This is done on the basis of each system's performance to published specifications, (relative to each other) and on the manufacturing process capability characteristics of the finished mask/reticle.

  6. LHC Beam Dump Design Study - Part III : Off-normal operating conditions

    CERN Document Server

    Bruno, L; Ross, M; Sala, P

    2000-01-01

    The LHC beam dump design study has been preliminarily substantiated by energy deposition simulations (Part I) and heat transfer analyses (Part II). The present report is devoted to the abnormal operating conditions induced by a malfunction of the beam diluters. A general approach to the analysis of off-normal operation is presented, which is derived from standard design norms adopted in the nuclear industry. Attention is focused mainly on the carbon core, which is longitudinally split into segments of different density in order to better distribute the deposited energy. The maximum energy density it absorbs decreases by at least 33%, compared to a uniform standard density carbon core. This structure may sustain any partial sweep failure without major damage, up to the ultimate beam intensity and energy. To minimise the risks inherent in a fully unswept beam, a sacrificial graphite mandrel will be placed on the core axis, surrounded by a thick high strength carbon-carbon composite tube. With this arrangement, ...

  7. Ln(III)-malate complexation studies using TRLFS and micro titration calorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Taube, F.; Drobot, B. [Technische Univ. Dresden (Germany). Professorship Radiochemistry; Acker, M.; Taut, S. [Technische Univ. Dresden (Germany). Central Radionuclide Laboratory; Stumpf, Thorsten [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Inst. of Resource Ecology

    2017-06-01

    The complexation of trivalent lanthanides was studied using Time-Resolved Laser-Induced Fluorescence Spectroscopy (TRLFS) and Isothermal Titration Calorimetry (ITC). Formation constants, complexation enthalpies and fluorescence lifetimes are determined over a wide pH range at I = 0.5 m NaCl. This subject has the following background: Concrete is widely used as engineering barrier and for waste conditioning in waste repositories. Its binding agent is cement. Organic cement additives, which are used to improve the workability of fresh concrete, are complexation agents for radionuclides after they have been released during the concretes degradation. Thus, these additives might have an impact on the aqueous geochemistry of actinides. Here, the α-hydroxydicarboxylic acid or malic acid is examined. It is used in water-reducers or retarders in cement.

  8. Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus.

    Science.gov (United States)

    Cervenka, Mackenzie C; Hocker, Sara; Koenig, Matthew; Bar, Barak; Henry-Barron, Bobbie; Kossoff, Eric H; Hartman, Adam L; Probasco, John C; Benavides, David R; Venkatesan, Arun; Hagen, Eliza C; Dittrich, Denise; Stern, Tracy; Radzik, Batya; Depew, Marie; Caserta, Filissa M; Nyquist, Paul; Kaplan, Peter W; Geocadin, Romergryko G

    2017-03-07

    To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was significant urine and serum ketone body production as a biomarker of feasibility. Secondary measures included resolution of SRSE, disposition at discharge, KD-related side effects, and long-term outcomes. Twenty-four adults were screened for participation at 5 medical centers, and 15 were enrolled and treated with a classic KD via gastrostomy tube for SRSE. Median age was 47 years (interquartile range [IQR] 30 years), and 5 (33%) were male. Median number of antiseizure drugs used before KD was 8 (IQR 7), and median duration of SRSE before KD initiation was 10 days (IQR 7 days). KD treatment delays resulted from intravenous propofol use, ileus, and initial care received at a nonparticipating center. All patients achieved ketosis in a median of 2 days (IQR 1 day) on KD. Fourteen patients completed KD treatment, and SRSE resolved in 11 (79%; 73% of all patients enrolled). Side effects included metabolic acidosis, hyperlipidemia, constipation, hypoglycemia, hyponatremia, and weight loss. Five patients (33%) ultimately died. KD is feasible in adults with SRSE and may be safe and effective. Comparative safety and efficacy must be established with randomized placebo-controlled trials. This study provides Class IV evidence that in adults with SRSE, a KD is effective in inducing ketosis. © 2017 American Academy of Neurology.

  9. HIV Testing in Urban Transgender Individuals: A Descriptive Study

    OpenAIRE

    Juarez-Cuellar, Adrian; Chang, Yu-Ping

    2017-01-01

    Abstract HIV testing is considered the initial component of HIV eradication strategies. This study aimed to describe HIV testing in urban, transgender individuals in western New York. The study uses HIV testing intake data from a sample of self-identified transgender males and females volunteering for an HIV test at a community-based healthcare organization. Transgender individuals with some characteristics were found to have more HIV tests including female gender, black, HIV status (positive...

  10. Application for a Permit to Operate a Class III Solid Waste Disposal Site at the Nevada Test Site Area 5 Asbestiform Low-Level Solid Waste Disposal Site

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Programs

    2010-09-14

    The NTS solid waste disposal sites must be permitted by the state of Nevada Solid Waste Management Authority (SWMA). The SWMA for the NTS is the Nevada Division of Environmental Protection, Bureau of Federal Facilities (NDEP/BFF). The U.S. Department of Energy's National Nuclear Security Administration Nevada Site Office (NNSA/NSO) as land manager (owner), and National Security Technologies (NSTec), as operator, will store, collect, process, and dispose all solid waste by means that do not create a health hazard, a public nuisance, or cause impairment of the environment. NTS disposal sites will not be included in the Nye County Solid Waste Management Plan. The NTS is located approximately 105 kilometers (km) (65 miles [mi]) northwest of Las Vegas, Nevada (Figure 1). The U.S. Department of Energy (DOE) is the federal lands management authority for the NTS, and NSTec is the Management and Operations contractor. Access on and off the NTS is tightly controlled, restricted, and guarded on a 24-hour basis. The NTS has signs posted along its entire perimeter. NSTec is the operator of all solid waste disposal sites on the NTS. The Area 5 RWMS is the location of the permitted facility for the Solid Waste Disposal Site (SWDS). The Area 5 RWMS is located near the eastern edge of the NTS (Figure 2), approximately 26 km (16 mi) north of Mercury, Nevada. The Area 5 RWMS is used for the disposal of low-level waste (LLW) and mixed low-level waste. Many areas surrounding the RWMS have been used in conducting nuclear tests. A Notice of Intent to operate the disposal site as a Class III site was submitted to the state of Nevada on January 28, 1994, and was acknowledged as being received in a letter to the NNSA/NSO on August 30, 1994. Interim approval to operate a Class III SWDS for regulated asbestiform low-level waste (ALLW) was authorized on August 12, 1996 (in letter from Paul Liebendorfer to Runore Wycoff), with operations to be conducted in accordance with the &apos

  11. Coal feeder development program. Phase III report

    Energy Technology Data Exchange (ETDEWEB)

    1979-09-01

    As a result of the work carried out in Phases I and II, the Kinetic Extruder was selected for further development during Phase III. Design studies were performed to identify components of the Kinetic Extruder which had an important impact on performance. These components were optimized and subjected to testing in the coal feeder test loop. The improved components were incorporated in the design of the Kinetic Extruder, Model No. 3, which was successfully tested up to 400 psig. The Kinetic Extruder Model No. 4 was designed to incorporate low differential pressure seals and provision for fluidic turndown control. This machine is ready for testing and engineering evaluation.

  12. Regional Disparities in Sedentary Behaviors and Meal Frequency in Iranian Adolescents: The CASPIAN-III Study

    Science.gov (United States)

    Baygi, Fereshteh; Heshmat, Ramin; Kelishadi, Roya; Mohammadi, Fatemeh; Motlagh, Mohammad Esmail; Ardalan, Gelayol; Asayesh, Hamid; Larijani, Bagher; Qorbani, Mostafa

    2015-01-01

    Background: The prevalence of obesity is increasing among Iranian youngsters like other developing countries. Objectives: This study was conducted to assess regional disparities in sedentary behaviors and meal frequency in Iranian adolescents. Patients and Methods: In this national survey, 5682 students aged 10 - 18 years from urban and rural districts of 27 provinces of Iran were selected via stratified multi-stage sampling method. The country was classified into four sub-national regions, based on criteria of the combination of geography and socioeconomic status (SES). Mean of meal frequency and physical activity levels as well as prevalence of omitting meals and sedentary behavior were compared across regions with different SES after stratifying with sex and age group. Results: Meal frequency in lower socio-economic regions was significantly higher than two other regions in 10 - 13 and 10 - 18 years old groups (P trend 0.05). Frequency of adolescents omitting their meals was higher in higher SES regions especially in West Iran (P < 0.001) in 10 - 13 years old age group. Having personal computer and working with it more than two hours per day mainly was observed in central Iran which ranked as the highest SES group. Conclusions: Efforts to ensure Iranian youth meet healthy food habits and screen time guidelines include limiting access to screen technologies and encouraging parents to monitor their own screen time is required. PMID:26195993

  13. Making Test Anxiety a Laughing Matter: A Quantitative Study

    Science.gov (United States)

    Repass, Jim T.

    2017-01-01

    Relieving test anxiety actions range from relaxation exercises to prescription medication. Humor can be a simple method of test anxiety relief. The current study was used to determine if humor, in the form of a cartoon, placed on the splash page of an online exam improved the test scores of students who have high test anxiety. In the current…

  14. A Framework for Testing Scientific Software: A Case Study of Testing Amsterdam Discrete Dipole Approximation Software

    Science.gov (United States)

    Shao, Hongbing

    Software testing with scientific software systems often suffers from test oracle problem, i.e., lack of test oracles. Amsterdam discrete dipole approximation code (ADDA) is a scientific software system that can be used to simulate light scattering of scatterers of various types. Testing of ADDA suffers from "test oracle problem". In this thesis work, I established a testing framework to test scientific software systems and evaluated this framework using ADDA as a case study. To test ADDA, I first used CMMIE code as the pseudo oracle to test ADDA in simulating light scattering of a homogeneous sphere scatterer. Comparable results were obtained between ADDA and CMMIE code. This validated ADDA for use with homogeneous sphere scatterers. Then I used experimental result obtained for light scattering of a homogeneous sphere to validate use of ADDA with sphere scatterers. ADDA produced light scattering simulation comparable to the experimentally measured result. This further validated the use of ADDA for simulating light scattering of sphere scatterers. Then I used metamorphic testing to generate test cases covering scatterers of various geometries, orientations, homogeneity or non-homogeneity. ADDA was tested under each of these test cases and all tests passed. The use of statistical analysis together with metamorphic testing is discussed as a future direction. In short, using ADDA as a case study, I established a testing framework, including use of pseudo oracles, experimental results and the metamorphic testing techniques to test scientific software systems that suffer from test oracle problems. Each of these techniques is necessary and contributes to the testing of the software under test.

  15. Synthesis, Characterization and Thermal Decomposition Studies of Cr(III), Mn(II) and Fe(III) Complexes of N, N '-Bis[1,3-benzodioxol-5-ylmethylene]butane-1,4-diamine

    National Research Council Canada - National Science Library

    Prasad M. Alex; K. K. Aravindakshan

    2009-01-01

    ... (3,4-dioxymethylenebenzaldehyde) with butane-1,4-diamine. Cr(III), Mn(II), Fe(III) complexes of this chelating ligand were synthesised using acetates, chlorides, bromides, nitrates and perchlorates of these metals...

  16. Estudo polarográfico sobre a determinação de Fe(III utilizando-se a técnica da polarografia de pulso diferencial Polarographic study about the determination of Fe(III using the technique of differencial pulse polarography

    Directory of Open Access Journals (Sweden)

    Luiz Manoel Aleixo

    2001-12-01

    Full Text Available A differential pulse polarographic study with the objective to determine iron (III in presense of copper (II in a supporting electrolyte based on citrate - EDTA was made. The best experimental conditions found were a supporting electrolyte of citrate 0.25 mol L-1, EDTA 0.050 mol L-1 and KNO3 0.50 mol L-1, pH 5.00. In this media iron (III showed a polarographic peak in -0.08 V and the copper (II in -0.34 V, both vs. Ag/AgCl (saturated KCl. Thus, a analytical method was developed and applied to determine iron (III in brass alloy, a matrix were copper is in large excess over iron. The results obtained showed no interference of copper in the iron determination. The value of 0.21% of iron in the sample alloy composition was obtained and the method was validated by atomic absortion and recovery test, and the results exhibited a good agreement with the proposed method.

  17. Long-Term Study of Children With ROME III Functional Gastrointestinal Disorders Managed Symptomatically in a Biopsychosocial Model.

    Science.gov (United States)

    Madani, Shailender; Parikh, Suchi; Madani, Rohit S; Krasaelap, Amornluck

    2017-04-01

    Our study evaluated progression of and identified potential factors contributing to outcomes of ROME III defined-functional gastrointestinal disorders (FGIDs) in children treated symptomatically in a biopsychosocial model of care with a long-term follow-up. We performed a retrospective review of pediatric patients who were diagnosed with ROME III defined-FGIDs including functional abdominal pain, functional dyspepsia, irritable bowel syndrome and abdominal migraine. Patients were managed symptomatically in a biopsychosocial model of care from the time of initial diagnosis. Demographics, management, progression and response to treatment assessed as complete, partial, and no improvement were reviewed. Two hundred fifty-eight patients were included with mean age of 10.6 years, female 55.4%, mean number of encounters 3.3 visits, and mean follow-up was 18.7 months (range 2 - 59, SD 15.8). Diagnoses were functional abdominal pain 45%, irritable bowel syndrome 20.9%, multiple 13.2%, functional dyspepsia 12.8%, and abdominal migraine 8.1%. Investigations were performed in most patients: laboratory studies in 93.4% (non-contributory abnormal 23.6%), imaging studies in 45.3% (non-contributory abnormal 5%) and endoscopies in 43.0% (non-contributory abnormal 1.2%). Treatment included medication in 93.7%, and surgery in 1.9% (normal pathology). There were new functional gastrointestinal diagnosis in 11.6%, evolution of FGIDs, from one to another in 12.0%, and recurrence found in 35.7% of patients. There were 60.1% patients in the complete improvement group (CIG) and 39.1% in the partial/no improvement group (PIG/NIG). No statistical difference was found between CIG and PIG/NIG regarding demographics or evaluation. PIG/NIG had more encounters (mean 3.63 vs. 3.11; P = 0.03), had non-contributory lab abnormalities (34.4% vs. 20.0%; P = 0.01), needed more endoscopies (52.4% vs. 36.8%; P = 0.02), required more treatment changes (mean 1.41 vs. 0.81; P biopsychosocial model of care is

  18. Integrating psychopathology and personality disorders conceptualized by the MMPI-2-RF and the MCMI-III: A structural validity study

    NARCIS (Netherlands)

    Heijden, P.T. van der; Egger, J.I.M.; Rossi, G.M.P.; Derksen, J.J.L.

    2012-01-01

    The Minnesota Multiphasic Personality Inventory-2-Restructured Form (Ben-Porath & Tellegen, 2008) Restructured Clinical scales and Higher Order scales were linked to the Millon Clinical Multiaxial Inventory-III ( Millon, Millon, Davis, & Grossman, 2009) personality disorder scales and clinical

  19. Idaho Water Rental Pilot Project Probability/Coordination Study Resident Fish and Wildlife Impacts Phase III, 1997 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Leitzinger, Eric J. (Idaho Department of Fish and Game, Boise, ID)

    1998-10-01

    Phase III began in 1995 with the overall goal of quantifying changes in resident fish habitat in the Snake River Basin upstream of Brownlee Reservoir resulting from the release of salmon flow augmentation water.

  20. Short-term effects of a modified Alt-RAMEC protocol for early treatment of Class III malocclusion: a controlled study.

    Science.gov (United States)

    Masucci, C; Franchi, L; Giuntini, V; Defraia, E

    2014-11-01

    To assess the effects of a modified alternate rapid maxillary expansion and constriction (Alt-RAMEC) protocol in combination with facemask (FM) in Class III growing patients. Thirty one Class III patients (17 males, 14 females) were treated with a modified Alt-RAMEC/FM protocol at the Department of Orthodontics of the University of Florence. All patients were evaluated at the beginning (T1, mean age 6.4 ± 0.8 years) and at the end of orthopedic therapy (T2, mean age 8.1 ± 0.9 years), and they were compared to a matched sample of 31 Class III patients (16 males and 15 females) treated with rapid maxillary expansion and facemask (RME/FM) and to a matched control group of 21 subjects (9 males and 12 females) with untreated Class III malocclusion. The three groups were compared with anova with Benjamini-Hochberg correction for multiple tests. Both the Alt-RAMEC/FM and the RME/FM protocols showed significantly favorable effects leading to correction of the Class III malocclusion. The Alt-RAMEC/FM protocol produced a more effective advancement of the maxilla (SNA +1.2°) and greater intermaxillary changes (ANB +1.7°) vs. the RME/FM protocol. No significant differences were recorded as for mandibular skeletal changes and vertical skeletal relationships. The Alt-RAMEC/FM protocol induced more favorable skeletal short-term effects compared with RME/FM therapy in Class III growing patients. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. EPR and 55Mn cw-ENDOR study of an antiferrogmagnetically coupled dinuclear manganese (Mn III Mn IV) complex

    Science.gov (United States)

    Zweygart, W.; Bittl, R.; Wieghardt, K.; Lubitz, W.

    1996-10-01

    X- and Q-band EPR and 55Mn cw-ENDOR experiments are reported on a binuclear oxo-bridged dimanganese Mn III Mn IV complex. Consistent simulations of spectra from both frequency bands using one parameter set for the orthorhombic g tensor and Mn III and Mn IV hyperfine tensors are achieved. Information on the manganese hyperfine couplings is independently obtained from 55Mn cw-ENDOR spectroscopy performed on both ions.

  2. Studies on the feasibility of using completely incinerable reagents for the single-cycle separation of americium(III) from simulated high-level liquid waste

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, P.K.; Kumaresan, R.; Venkatesan, K.A.; Subramanian, G.G.S.; Prathibha, T.; Syamala, K.V.; Selvan, B. Robert; Rajeswari, S.; Antony, M.P.; Rao, P.R. Vasudeva [Indira Gandhi Centre for Atomic Research, Kalpakkam (India). Fuel Chemistry Div.; Chaurasia, Shivkumar; Bhanage, B.M. [Institute of Chemical Technology, Mumbai (India)

    2015-06-01

    The extraction and stripping behavior of various metal ions present in the fast reactor simulated high-level liquid waste (FR-SHLLW) was studied using a solvent phase composed of a neutral extractant, N,N,-didodecyl-N',N'-dioctyl-3-oxapentane-1,5-diamide (D{sup 3}DODGA) and an acidic extractant, di-2-ethylhexyl diglycolamic acid (HDEHDGA) in n-dodecane (n-DD). The third phase formation behavior of the solvent formulation D{sup 3}DODGA + HDEHDGA/n-DD, was studied when it was contacted with FR-SHLLW, and the concentration of neutral and acidic extractant needed to avoid the third phase formation was optimized. The distribution ratio of various metal ions present in FR-SHLLW was measured in a solution of 0.1 M D{sup 3}DODGA + 0.2 M HDEHDGA/n-DD. The extraction of Am(III) was accompanied by the co-extraction of lanthanides and unwanted metal ions such as Zr(IV), Y(III), and Pd(II). A procedure was developed to minimize the extraction of unwanted metal ions by using aqueous soluble complexing agents in FR-SHLLW. Based on those results, the counter-current mixer-settler run was performed in a 20-stage mixer-settler. Quantitative extraction of Am(III), Ln(III), Y(III), and Sr(II) in 0.1 M D{sup 3}DODGA + 0.2 M HDEHDGA/n-DD was observed. The recovery of Am(III) from the loaded organic phase was carried out by the optimized aqueous formulation composed of 0.01 M diethylenetriaminepentaacetic acid (DTPA) + 0.5 M citric acid (CA) at pH 1.5. The stripping of Am(III) was accompanied by co-stripping of some early lanthanides. However the later lanthanides (Eu(III) and beyond) were not back extracted to Am(III) product. Therefore, the studies foresee the possibility of intra-lanthanides as well as lanthanide-actinide separation in a single-processing cycle.

  3. Motivations to participate in a Phase I/II HIV vaccine trial: A descriptive study from Dar es Salaam, Tanzania

    Directory of Open Access Journals (Sweden)

    E. A. M. Tarimo

    2016-02-01

    Full Text Available Abstract Background The search for an efficacious HIV vaccine is a global priority. To date only one HIV vaccine trial (RV144 has shown modest efficacy in a phase III trial. With existing different HIV-1 subtypes and frequent mutations, multiple trials are needed from different geographical sites particularly in sub-Saharan Africa where most HIV infections occur. Thus, motivations to participate in HIV vaccine trials among Tanzanians need to be assessed. This paper describes the motives of Police Officers who showed great interest to volunteer in HIVIS-03 in Dar es Salaam, Tanzania. Methods A descriptive cross-sectional study was conducted among Police Officers who showed interest to participate in the HIVIS-03, a phase I/II HIV vaccine trial in Dar es Salaam. Prior to detailed training sessions about HIV vaccine trials, the potential participants narrated their individual motives to participate in the trial on a piece of paper. Descriptive analysis using content approach and frequency distributions were performed. Results Of the 265 respondents, 242 (91.3 % provided their socio-demographic characteristics as well as reasons that would make them take part in the proposed trial. Majority, (39.7 %, cited altruism as the main motive. Women were more likely to volunteer due to altruism compared to men (P < 0.01. Researchers’ explanations about HIV/AIDS vaccine studies motivated 15.3 %. More men (19.6 % than women (1.7 % were motivated to volunteer due to researchers’ explanations (P < 0.001. Also, compared to other groups, those unmarried and educated up to secondary level of education were motivated to volunteer due to researchers’ explanation (P < 0.05. Other reasons were: desire to become a role model (18.6 %; to get knowledge for educating others (14.0 %; to cooperate with researchers in developing an HIV vaccine (9.5 %; to get protection against HIV infection (7.0 %, and severity of the disease within families (6.2

  4. Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents: the CASPIAN-III Study.

    Science.gov (United States)

    Safiri, Saeid; Qorbani, Mostafa; Heshmat, Ramin; Tajbakhsh, Ramin; Eslami Shahr Babaki, Amir; Djalalinia, Shirin; Motlagh, Mohammad Esmaeil; Tajadini, Mohammad Hasan; Asayesh, Hamid; Safari, Omid; Kelishadi, Roya

    2016-05-01

    There is controversial evidence on association of serum acid uric (SUA) with cardiometabolic risk factors and metabolic syndrome in adults. This study aimed to investigate the associations of SUA levels, components of metabolic syndrome, and other cardiometabolic risk factors, in a nationally representative sample of Iranian adolescents. This study included 132 participants who met the criteria of metabolic syndrome and 235 participants without metabolic syndrome. The participants were grouped according to the tertiles of SUA. Metabolic syndrome was defined according to the Adult Treatment Panel III criteria modified for children and adolescents. The relationship between SUA and cardiometabolic risk factors and metabolic syndrome was assessed by multivariable logistic regression analysis. The mean age of the participants was 15.21 ± 2.35 years, with no significant difference between the boys and the girls. The participants whose SUA was categorized in the 2nd tertile and those falling into the 3rd tertile had significantly higher systolic blood pressure (P Metabolic syndrome was associated with the 2nd and 3rd tertiles of SUA as compared to the lower tertile(s), in the adjusted model (P metabolic syndrome had higher SUA levels. Its association with some components of metabolic syndrome supports that SUA might be an additional component of metabolic syndrome even during adolescence.

  5. RF thermal and new cold part design studies on TTF-III input coupler for Project-X

    Energy Technology Data Exchange (ETDEWEB)

    Pei, Shilun [Chinese Academy of Sciences (CAS), Beijing (China); Adolphsen, Chris E. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Li, Zenghai [SLAC National Accelerator Lab., Menlo Park, CA (United States); Solyak, Nikolay A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Gonin, Ivan V. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2015-05-15

    An RF power coupler is one of the key components in a superconducting (SC) linac. It provides RF power to the SC cavity and interconnects different temperature layers (1.8 K, 4.2 K, 70 K and 300 K). The TTF-III coupler is one of the most promising candidates for the High Energy (HE) linac of Project X, but it cannot meet the average power requirements because of the relatively high temperature rise on the warm inner conductor, so some design modifications will be required. In this paper, we describe our simulation studies on the copper coating thickness on the warm inner conductor with RRR values of 10 and 100. Our purpose is to rebalance the dynamic and static loads, and finally lower the temperature rise along the warm inner conductor. Additionally, to get stronger coupling, better power handling and less multipacting probability, one new cold part design was proposed using a 60 mm coaxial line; the corresponding multipacting simulation studies have also been investigated.

  6. Thermoanalytical, spectroscopic and DFT studies of heavy trivalent lanthanides and yttrium(III) with oxamate as ligand

    Energy Technology Data Exchange (ETDEWEB)

    Caires, Flavio Junior; Gaglieri, Caroline, E-mail: caires.flavio@fc.unesp.br [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Bauru, SP (Brazil). Faculdade de Ciencias; Nunes, Wilhan Donizete Goncalves; Nascimento, Andre Luiz Carneiro Soares do; Teixeira, Jose Augusto; Zangaro, Georgia Alvim Coelho; Treu-Filho, Oswaldo; Ionashiro, Massao [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Araraquara, SP (Brazil)

    2017-07-15

    Solid-state LnL{sub 3}∙nH{sub 2}O complexes, where Ln stands for trivalent lanthanides (Tb to Lu) or yttrium(III) and L is oxamate (NH{sub 2}COCO{sub 2}{sup -}), have been synthesized. The characterization of the complexes was performed by using elemental analysis (EA), complexometric titration with EDTA, thermoanalytical techniques such as simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), evolved gas analysis (TG-FTIR), infrared spectroscopy (IR) and powder X-ray diffraction (XRPD). The results provided information about thermal behavior, crystallinity, stoichiometry, coordination sites, as well as the products released during thermal degradation of the complexes studied. Theoretical calculation of yttrium oxamate, as representative of all complexes was performed using density functional theory (DFT) for studying the molecular structure and vibrational spectrum of the investigated molecule in the ground state. The optimized geometrical parameters and theoretical vibrational spectrum obtained by DFT calculations are in good agreement with the experimental results. (author)

  7. Family Dinner Frequency is Inversely Related to Mental Disorders and Obesity in Adolescents: the CASPIAN-III Study.

    Science.gov (United States)

    Haghighatdoost, Fahimeh; Kelishadi, Roya; Qorbani, Mostafa; Heshmat, Ramin; Motlagh, Mohammad Esmaeil; Ardalan, Gelayol; Azadbakht, Leila

    2017-04-01

    Family dinner is a proxy of family connectedness that may affect mental health. The present study aimed to examine the associations of frequency of family dinner with mental disorders and obesity in a nationally-representative sample of Iranian adolescents. A total of 5528 Iranians adolescents aged 10-18 years were enrolled in 2009-2010 in the third survey of a national surveillance program, entitled Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable disease (CASPIAN-III) study. The frequency of family dinner meal was assessed. Mental health assessments were done as part of the World Health Organization-Global School-based Student Health Survey. The odds of having mental disorders and obesity were assessed by logistic regression. No significant difference was found in dietary intake between family dinner consumers (≥5 times (night)/wk) and skippers (family dinner consuming and mental disorders and obesity in a nationally-representative sample of Iranian adolescents. Such simple recommendations for consuming family dinner for families may be feasible, sustainable, and effective for health promotion and disease prevention.

  8. Coastal circulation and sediment dynamics in Hanalei Bay, Kaua'i, Hawaii, part III, studies of sediment toxicity

    Science.gov (United States)

    Carr, Robert S.; Nipper, Marion; Field, Michael; Biedenbach, James M.

    2006-01-01

    Toxicity tests are commonly conducted as a measure of the bioavailability of toxic chemicals to biota in an environment. Chemical analyses alone are insufficient to determine whether contaminants pose a threat to biota. Porewater toxicity tests are extremely sensitive to a broad range of contaminants in marine environments and provide ecologically relevant data on sensitive life stages. The inclusion of porewater toxicity testing as an additional indicator of sediment quality provides a more comprehensive picture of contaminant effects in these sensitive habitats. In this study purple-spined sea urchin (Arbacia punctulata) fertilization and embryological development porewater toxicity tests were used to evaluate the sediments collected from the coastal environment around Hanalei Bay, Kaua’i, Hawaii. These tests have been used previously to assess the bioavailability of contaminants associated with sediments in the vicinity of coral reefs.

  9. A National Study of Internal Medicine--Phase III. Analysis of 1976-1977 Resident Cohort Currently in Practice. Final Report.

    Science.gov (United States)

    Schleiter, Mary Kay; Tarlov, Alvin R.

    The different practice styles of young internists and the relationship between training and practice were studied as part of the National Study of Internal Medicine Manpower, Phase III. The practices of four groups of physicians were compared: general internists with traditional residencies, general internists who received their residency training…

  10. Blood Test Can Screen for Rare Sinus Cancer, Study Finds

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_167694.html Blood Test Can Screen for Rare Sinus Cancer, Study Finds ... Aug. 9, 2017 (HealthDay News) -- A new DNA blood test can catch a rare but deadly form of ...

  11. The Feasibility of Administering a Practical Clinical Examination in Podiatry at a College of Podiatric Medicine: Results of a Field Trial Under Simulated Part III Test Conditions.

    Science.gov (United States)

    And Others; Valletta, Michael

    1978-01-01

    The results of a practical clinical examination in podiatric medicine administered to fourth-year students are presented. The examination could become the prototype of a Part III practical clinical examination under the auspices of the National Board of Podiatry Examiners. Its feasibility is established and problems and issues are discussed.…

  12. Cladribine tablets for relapsing-remitting multiple sclerosis: Efficacy across patient subgroups from the phase III CLARITY study.

    Science.gov (United States)

    Rammohan, Kottil; Giovannoni, Gavin; Comi, Giancarlo; Cook, Stuart; Rieckmann, Peter; Soelberg Sørensen, Per; Vermersch, Patrick; Hamlett, Anthony; Kurukulasuriya, Nuwan

    2012-01-01

    In the phase III CLARITY study, treatment with cladribine tablets at cumulative doses of 3.5 or 5.25mg/kg over 96 weeks led to significant reductions in annualized relapse rates (ARR) versus placebo in patients with relapsing-remitting multiple sclerosis. Further post hoc analyses of CLARITY study data were conducted to determine the efficacy of cladribine tablets across patient subgroups stratified by baseline characteristics. Relapse rates over the 96-week CLARITY study were analyzed in cohorts stratified by demographics; disease duration; treatment history and disease activity at baseline. In the intent-to-treat population (n=437, 433 and 456 in the placebo, cladribine 3.5 and 5.25mg/kg groups, respectively), treatment with cladribine tablets 3.5 and 5.25mg/kg led to consistent improvements in ARR versus placebo in patients stratified by gender; age (≤40/>40 years); disease duration (10 years); prior disease-modifying drug treatment (treated/naïve); relapses in the prior year (≤1/2/≥3); Expanded Disability Status Scale score (median) at baseline (all P≤0.05 for reduction in the relative risk of relapse [cladribine tablets versus placebo]). Significant effects were also observed in patients who had only one relapse in the year prior to study entry (n=306, 303 and 323 in the placebo, cladribine 3.5 and 5.25mg/kg groups, respectively) and who were further stratified according to other measures of disease activity at baseline. Treatment with cladribine tablets provides consistent reductions in ARR compared with placebo across the spectrum of baseline demographics and disease characteristics represented in the CLARITY study. Copyright © 2011 Elsevier B.V. All rights reserved.

  13. A class III chitinase without disulfide bonds from the fern, Pteris ryukyuensis: crystal structure and ligand-binding studies.

    Science.gov (United States)

    Kitaoku, Yoshihito; Umemoto, Naoyuki; Ohnuma, Takayuki; Numata, Tomoyuki; Taira, Toki; Sakuda, Shohei; Fukamizo, Tamo

    2015-10-01

    We first solved the crystal structure of class III catalytic domain of a chitinase from fern (PrChiA-cat), and found a structural difference between PrChiA-cat and hevamine. PrChiA-cat was found to have reduced affinities to chitin oligosaccharides and allosamidin. Plant class III chitinases are subdivided into enzymes with three disulfide bonds and those without disulfide bonds. We here referred to the former enzymes as class IIIa chitinases and the latter as class IIIb chitinases. In this study, we solved the crystal structure of the class IIIb catalytic domain of a chitinase from the fern Pteris ryukyuensis (PrChiA-cat), and compared it with that of hevamine, a class IIIa chitinase from Hevea brasiliensis. PrChiA-cat was found to adopt an (α/β)8 fold typical of GH18 chitinases in a similar manner to that of hevamine. However, PrChiA-cat also had two large loops that extruded from the catalytic site, and the corresponding loops in hevamine were markedly smaller than those of PrChiA-cat. An HPLC analysis of the enzymatic products revealed that the mode of action of PrChiA-cat toward chitin oligosaccharides, (GlcNAc) n (n = 4-6), differed from those of hevamine and the other class IIIa chitinases. The binding affinities of (GlcNAc)3 and (GlcNAc)4 toward the inactive mutant of PrChiA-cat were determined by isothermal titration calorimetry, and were markedly lower than those toward other members of the GH18 family. The affinity and the inhibitory activity of allosamidin toward PrChiA-cat were also lower than those toward the GH18 chitinases investigated to date. Several hydrogen bonds found in the crystal structure of hevamine-allosamidin complex were missing in the modeled structure of PrChiA-cat-allosamidin complex. The structural findings for PrChiA-cat successfully interpreted the functional data presented.

  14. Optimal Trend Tests for Genetic Association Studies of Heterogeneous Diseases.

    Science.gov (United States)

    Lee, Wen-Chung

    2016-06-09

    The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventional Cochran-Armitage trend test is striking when the genetic effects are heterogeneous. The easy-to-use R 3.1.2 software (R Foundation for Statistical Computing, Vienna, Austria) code is provided. The optimal trend tests are recommended for routine use.

  15. A study of the coordination shell of aluminum(III) and magnesium(II) in model protein environments: thermodynamics of the complex formation and metal exchange reactions.

    Science.gov (United States)

    Rezabal, Elixabete; Mercero, Jose M; Lopez, Xabier; Ugalde, Jesus M

    2006-03-01

    Al(III) toxicity in living organisms is based on competition with other metal cations. Mg(II) is one of the most affected cations, since the size similarity dominates over the charge identity. The slow ligand exchange rates for Al(III) render the ion useless as a metal ion at the active sites of enzymes and provide a mechanism by which Al(III) inhibits Mg(II) dependent biochemical processes. Al(III) cation interactions with relevant bioligands have been studied in a protein-model environment in gas and aqueous phases using density functional theory methods. The protein model consists of the metal cation bound to two chosen bioligands (functional groups of the amino acid side chains, one of them being always an acetate) and water molecules interacting with the cation to complete its first coordination shell. Analogous Mg(II) complexes are calculated and compared with the Al(III) ones. Formation energies of the complexes are calculated in both phases and magnesium/aluminum exchange energies evaluated. The effect of different dielectric media is also analyzed. The presence of an acetate ligand in the binding site is found to promote both, complex formation and metal exchange reactions. In addition, buried binding sites (with low dielectric constant) of the protein favor metal exchange, whereas fully solvated environments of high dielectric constant require the presence of two anionic ligands for metal exchange to occur.

  16. Evaluation and Comparison of Intermaxillary Tooth Size Discrepancy among Class I, Class II Division 1, and Class III Subjects Using Bolton’s Analysis: An in vitro Study

    Science.gov (United States)

    Prasanna, A Lakshmi; Venkatramana, V; Aryasri, A Srikanth; Katta, Anil Kumar; Santhanakrishnan, K; Maheshwari, Uma

    2015-01-01

    Aim: The aim of the present study was to evaluation and comparison of intermaxillary tooth size discrepancy among Class I, Class II division 1, and Class III subjects using Bolton’s analysis. Materials and Methods: The pre-treatment casts were selected from the records of patients attending the Department of Orthodontics of Meenakshi Ammal Dental College, Chennai. The sample consists of 180 pre-treatment casts with both sexes evenly distributed with 60 casts in each type of malocclusion, i.e., Class I, Class II div 1, and Class III malocclusion. The sample was selected according to angles classification. All patients were Indian nationals, between the age group of 12 to 20 years and Bolton’s analysis done on all the casts. Results: Statistically no significant difference in all types of malocclusion except anterior Bolton’s discrepancy in Class III. Conclusion: Mean Bolton’s anterior ratio for angles Class III subjects was significantly greater than for Class I and Class II subjects. When Bolton’s overall ratio was compared there was no statistically significant difference among Class I, Class II div 1, and Class III malocclusions. PMID:26435619

  17. Viability testing of material derived from Mycobacterium tuberculosis prior to removal from a Containment Level-III Laboratory as part of a Laboratory Risk Assessment Program

    Directory of Open Access Journals (Sweden)

    Kabani Amin M

    2005-01-01

    Full Text Available Abstract Background In the field of clinical mycobacteriology, Mycobacterium tuberculosis (MTB can be a difficult organism to manipulate due to the restrictive environment of a containment level 3 (CL3 laboratory. Tests for rapid diagnostic work involving smears and molecular methods do not require CL3 practices after the organism has been rendered non-viable. While it has been assumed that after organism deactivation these techniques can be performed outside of a CL3, no conclusive study has consistently confirmed that the organisms are noninfectious after the theoretical 'deactivation' steps. Previous studies have shown that initial steps (such as heating /chemical fixation may not consistently kill MTB organisms. Methods An inclusive viability study (n = 226 was undertaken to determine at which point handling of culture extraction materials does not necessitate a CL3 environment. Four different laboratory protocols tested for viability included: standard DNA extractions for IS6110 fingerprinting, crude DNA preparations for PCR by boiling and mechanical lysis, protein extractions, and smear preparations. For each protocol, laboratory staff planted a proportion of the resulting material to Bactec 12B medium that was observed for growth for 8 weeks. Results Of the 208 isolates initially tested, 21 samples grew within the 8-week period. Sixteen (7.7% of these yielded positive results for MTB that included samples of: deactivated culture resuspensions exposed to 80°C for 20 minutes, smear preparations and protein extractions. Test procedures were consequently modified and tested again (n = 18, resulting in 0% viability. Conclusions This study demonstrates that it cannot be assumed that conventional practices (i.e. smear preparation or extraction techniques render the organism non-viable. All methodologies, new and existing, should be examined by individual laboratories to validate the safe removal of material derived from MTB to the outside of a

  18. Differentiation of functional constipation and constipation predominant irritable bowel syndrome based on Rome III criteria: a population-based study.

    Science.gov (United States)

    Koloski, N A; Jones, M; Young, M; Talley, N J

    2015-05-01

    While the Rome III classification recognises functional constipation (FC) and constipation predominant IBS (IBS-C) as distinct disorders, recent evidence has suggested that these disorders are difficult to separate in clinical practice. To identify whether clinical and lifestyle factors differentiate Rome III-defined IBS-C from FC based on gastrointestinal symptoms and lifestyle characteristics. 3260 people randomly selected from the Australian population returned a postal survey. FC and IBS-C were defined according to Rome III. The first model used logistic regression to differentiate IBS-C from FC based on lifestyle, quality-of-life and psychological characteristics. The second approach was data-driven employing latent class analysis (LCA) to identify naturally occurring clusters in the data considering all symptoms involved in the Rome III criteria for IBS-C and FC. We found n = 206 (6.5%; 95% CI 5.7-7.4%) people met strict Rome III FC whereas n = 109 (3.5%; 95% CI 2.8-4.1%) met strict Rome III IBS-C. The case-control approach indicated that FC patients reported an older age at onset of constipation, were less likely to exercise, had higher mental QoL and less health care seeking than IBS-C. LCA yielded one latent class that was predominantly (75%) FC, while the other class was approximately half IBS-C and half FC. The FC-dominated latent class had clearly lower levels of symptoms used to classify IBS (pain-related symptoms) and was more likely to be male (P = 0.046) but was otherwise similar in distribution of lifestyle factors to the mixed class. The latent class analysis approach suggests a differentiation based more on symptom severity rather than the Rome III view. © 2015 John Wiley & Sons Ltd.

  19. Interactions between cyclodextrins and TM{sup III} chelates of polyazamacrocycles as studied by NMR in aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Zitha-Bovens, E.; Bekkum, H. van; Peters, J.A. [Delft Univ. of Technology (Netherlands). Lab. of Organic Chemistry and Catalysis; Geraldes, C.F.G.C. [Coimbra Univ. (Portugal). Dept. of Biochemistry and Center of Neurosciences

    1999-02-01

    The interactions between {alpha}-, {beta}, and {gamma}-CD and the Tm{sup III} chelates of the macrocyclic polyaminopolycarboxylates DOTA and NOTA were studied with the use of {sup 1}H- and {sup 13}C-NMR shift and relaxation rate measurements. Interactions were only observed between Tm(DOTA){sup -} and {gamma}-CD. The structure and the stability of the concerning supramolecular structures was elucidated by fitting of the NMR titration curves to a theoretical model. It appears that an inclusion compound is formed, where the hydrophobic macrocyclic part of the chelate sits in the {gamma}-CD cavity. This inclusion compound binds a second Tm(DOTA){sup -} molecule at the outside lower rim of the CD cone. The binding occurs probably via hydrogen bonds between non-chelated carboxylate oxygen atoms of the concerning Tm(DOTA){sup -} and CH{sub 2}OH groups of the {gamma}-CD molecule, which are in a favorable position due to opening of the {gamma}-CD cone angle as a result of the inclusion of the first {gamma}-CD. (orig.)

  20. Postoperative stability of bimaxillary surgery in Class III patients with mandibular protrusion and mandibular deviation: a frontal cephalometric study.

    Science.gov (United States)

    Al-Gunaid, Talat; Yamada, Kazuhiro; Takagi, Ritsuo; Saito, Chikara; Saito, Isao

    2008-11-01

    The aims of this study into bimaxillary surgery were to investigate and compare the postoperative stability of deviated side (lengthened side) and non-deviated side (shortened side), the effect of the type of surgery performed in the mandible, and the changes in signs and symptoms of temporomandibular joint (TMJ) disorders before and after surgery. The sample consisted of 31 Class III patients in whom imbalance between the maxilla and the mandible were corrected by Le Fort I osteotomy combined with bilateral intraoral vertical ramus osteotomy (BIVRO group, n=9), bilateral sagittal split ramus osteotomy (BSSRO group, n=10), or IVRO and SSRO (IVRO+SSRO group, n=12). IVRO+SSRO and BIVRO are more effective in improving TMJ signs and symptoms. There was no significant post-surgical difference between deviated and non-deviated sides in any group. BIVRO and BSSRO showed excellent post-surgical stability on both sides; less was found in the IVRO+SSRO group. The IVRO+SSRO group showed greater transverse displacement in menton point than the BIVRO group. In conclusion, after bimaxillary surgery and in asymmetric patients there were no differences between deviated and non-deviated sides, BIVRO and BSSRO appear to be more stable than IVRO+SSRO.

  1. Thermoanalytical study of linkage isomerism in coordination compounds. Part III: A DSC study on the effect of counterion on the solid state isomerization of nitro and nitrito linkage isomers of pentaamminecobalt(III) complexes

    Energy Technology Data Exchange (ETDEWEB)

    Eslami, Abbas, E-mail: eslami@umz.ac.ir; Hasani, Nahid

    2014-01-10

    Graphical abstract: - Highlights: • The effect of counterion on solid state thermal isomerization of nitro and nitrito linkage isomers of pentaamminecobalt(III) complexes studied by DSC. • The different prepared salts of both isomers are in metastable state at room temperature which convert to an equilibrium stale state upon heating. • Change of the counterion affects thermodynamic parameters of the isomerization reaction, but the nitro isomer is always more stable than the nitrito one. • The kinetic parameters of the linkage isomerization depend significantly on the nature of the counterion. - Abstract: Solid state thermal interconversion of [Co(NH{sub 3}){sub 5}NO{sub 2}]X{sub 2} (nitro isomer) and [Co(NH{sub 3}){sub 5}ONO]X{sub 2} (nitrito isomer) complexes (X = Cl{sup −}, Br{sup −}, I{sup −}, PF{sub 6}{sup −}) was studied by DSC at several heating rates. The isomerization of pure sample of both isomers leads to an equilibrium stable state in which nitro and nitrito isomers are major and minor components, respectively. Change of the counterion affects thermodynamic parameters of the isomerization reaction, but the nitro isomer is always more stable than the nitrito one. The equilibrium constant (nitro to nitrito molar ratio) increases in the series Cl{sup −} ≈ Br{sup −} < PF{sub 6}{sup −} < I{sup −}. The kinetic parameters of isomerization of both isomers were determined by Kissinger method. It was founded that the rate of interconversion of different salts of both isomers decreases in the series Cl{sup −} > Br{sup −} > PF{sub 6}{sup −} > I{sup −}. The negative activation entropy supports an associative mechanism with a seven coordinate transition state in solid state.

  2. What do tests do for doctors? A qualitative study of blood testing in UK primary care.

    Science.gov (United States)

    Watson, Jessica; de Salis, Isabel; Banks, Jonathan; Salisbury, Chris

    2017-11-16

    Rates of blood testing are rising with significant geographical variability. Most research into diagnostic testing focuses on the role of tests in diagnostic decision-making. The aim of this study was to explore the non-medical motives for blood testing by considering what tests do for doctors, through qualitative interviews with general practitioners (GPs). We undertook 23 in-depth semi-structured interviews with UK GPs. Reasons for performing recent inflammatory marker blood tests were explored by reviewing GPs pathology inboxes to ground discussions in real-life clinical practice. Interviews were transcribed verbatim and analysed using a grounded theory approach. Blood tests offer doctors a tool to manage uncertainty; within a context of increased litigation, risk aversion and reduced continuity of care. Tests can also be offered as a 'gift' for patients, a way to be seen to be 'doing something'; in the social context of time pressures and perceived patient pressures. There was a tension however. On the one hand, doctors talked about using tests for reassurance and as a 'gift' offering 'truth'. Yet paradoxically, they also discussed the challenges of uncertainty and anxiety from inconclusive test results. Our study emphasises that defining 'unnecessary' blood testing may not be as simple as determining medical criteria for testing; psychosocial reasons may be equally valid and interlinked. Further research is needed to help GPs manage uncertainty within the context of a risk averse society, and to explore the congruence and dissonance between doctors' and patients' perceptions of testing.

  3. Reconstruction of type II+III pelvic resection with a modular hemipelvic endoprosthesis: a finite element analysis study.

    Science.gov (United States)

    Ji, Tao; Guo, Wei; Tang, Xiao-Dong; Yang, Yi

    2010-11-01

    To conduct a biomechanical study of the whole reconstructed pelvic ring using a modular hemipelvic endoprosthesis. A subject-specific finite-element (FE) model of the whole pelvic ring, including the pelvis, sacrum and main ligaments, was constructed. Type II+III pelvic resection was simulated on the FE model. Then a three-dimensional model of a reconstructed pelvic ring with a modular hemipelvic endoprosthesis was developed, and FE analysis performed to compare the stresses along the bilateral arcuate lines of the reconstructed and normal pelvis in the bipedal standing position. Comparison between bilateral stress distributions along the sciatic notch was also performed. The characteristics of load transmission within the endoprosthesis were also studied. No significant difference in the stresses along the bilateral arcuate lines was observed between the reconstructed and normal pelvis. The stress distribution on the prosthesis along the sciatic notch paths was significantly greater than that on the unaffected side in the same position. The peak stress of the implant on the S1 vertebral body was 182.9 MPa under a load of 600N. Study of load transfer on the implant showed that the posterior side of the column between the point of iliac fixation and the acetabulum was subject to the greatest stress. This FE study showed that a modular hemipelvic endoprosthesis can restore load transfer between the sacrum and acetabulum on simple standing. Future implant design should aim to decrease the stress concentration and make the biomechanical performance more balanced. © 2010 Tianjin Hospital and Blackwell Publishing Asia Pty Ltd.

  4. Monitoring safety in a phase III real-world effectiveness trial: use of novel methodology in the Salford Lung Study.

    Science.gov (United States)

    Collier, Sue; Harvey, Catherine; Brewster, Jill; Bakerly, Nawar Diar; Elkhenini, Hanaa F; Stanciu, Roxana; Williams, Claire; Brereton, Jacqui; New, John P; McCrae, John; McCorkindale, Sheila; Leather, David

    2017-03-01

    The Salford Lung Study (SLS) programme, encompassing two phase III pragmatic randomised controlled trials, was designed to generate evidence on the effectiveness of a once-daily treatment for asthma and chronic obstructive pulmonary disease in routine primary care using electronic health records. The objective of this study was to describe and discuss the safety monitoring methodology and the challenges associated with ensuring patient safety in the SLS. Refinements to safety monitoring processes and infrastructure are also discussed. The study results are outside the remit of this paper. The results of the COPD study were published recently and a more in-depth exploration of the safety results will be the subject of future publications. The SLS used a linked database system to capture relevant data from primary care practices in Salford and South Manchester, two university hospitals and other national databases. Patient data were collated and analysed to create daily summaries that were used to alert a specialist safety team to potential safety events. Clinical research teams at participating general practitioner sites and pharmacies also captured safety events during routine consultations. Confidence in the safety monitoring processes over time allowed the methodology to be refined and streamlined without compromising patient safety or the timely collection of data. The information technology infrastructure also allowed additional details of safety information to be collected. Integration of multiple data sources in the SLS may provide more comprehensive safety information than usually collected in standard randomised controlled trials. Application of the principles of safety monitoring methodology from the SLS could facilitate safety monitoring processes for future pragmatic randomised controlled trials and yield important complementary safety and effectiveness data. © 2016 The Authors Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons Ltd.

  5. Electronic structure of a weakly antiferromagnetically coupled Mn(II)Mn(III) model relevant to manganese proteins: a combined EPR, 55Mn-ENDOR, and DFT study.

    Science.gov (United States)

    Cox, Nicholas; Ames, William; Epel, Boris; Kulik, Leonid V; Rapatskiy, Leonid; Neese, Frank; Messinger, Johannes; Wieghardt, Karl; Lubitz, Wolfgang

    2011-09-05

    An analysis of the electronic structure of the [Mn(II)Mn(III)(μ-OH)-(μ-piv)(2)(Me(3)tacn)(2)](ClO(4))(2) (PivOH) complex is reported. It displays features that include: (i) a ground 1/2 spin state; (ii) a small exchange (J) coupling between the two Mn ions; (iii) a mono-μ-hydroxo bridge, bis-μ-carboxylato motif; and (iv) a strongly coupled, terminally bound N ligand to the Mn(III). All of these features are observed in structural models of the oxygen evolving complex (OEC). Multifrequency electron paramagnetic resonance (EPR) and electron nuclear double resonance (ENDOR) measurements were performed on this complex, and the resultant spectra simulated using the Spin Hamiltonian formalism. The strong field dependence of the (55)Mn-ENDOR constrains the (55)Mn hyperfine tensors such that a unique solution for the electronic structure can be deduced. Large hyperfine anisotropy is required to reproduce the EPR/ENDOR spectra for both the Mn(II) and Mn(III) ions. The large effective hyperfine tensor anisotropy of the Mn(II), a d(5) ion which usually exhibits small anisotropy, is interpreted within a formalism in which the fine structure tensor of the Mn(III) ion strongly perturbs the zero-field energy levels of the Mn(II)Mn(III) complex. An estimate of the fine structure parameter (d) for the Mn(III) of -4 cm(-1) was made, by assuming the intrinsic anisotropy of the Mn(II) ion is small. The magnitude of the fine structure and intrinsic (onsite) hyperfine tensor of the Mn(III) is consistent with the known coordination environment of the Mn(III) ion as seen from its crystal structure. Broken symmetry density functional theory (DFT) calculations were performed on the crystal structure geometry. DFT values for both the isotropic and the anisotropic components of the onsite (intrinsic) hyperfine tensors match those inferred from the EPR/ENDOR simulations described above, to within 5%. This study demonstrates that DFT calculations provide reliable estimates for spectroscopic

  6. Advanced ovarian cancer: phase III randomized study of sequential cisplatin-topotecan and carboplatin-paclitaxel vs carboplatin-paclitaxel.

    Science.gov (United States)

    Hoskins, P; Vergote, I; Cervantes, A; Tu, D; Stuart, G; Zola, P; Poveda, A; Provencher, D; Katsaros, D; Ojeda, B; Ghatage, P; Grimshaw, R; Casado, A; Elit, L; Mendiola, C; Sugimoto, A; D'Hondt, V; Oza, A; Germa, J R; Roy, M; Brotto, L; Chen, D; Eisenhauer, E A

    2010-10-20

    Topotecan has single-agent activity in recurrent ovarian cancer. It was evaluated in a novel combination compared with standard frontline therapy. Women aged 75 years or younger with newly diagnosed stage IIB or greater ovarian cancer, Eastern Cooperative Oncology Group Performance Status of 1 or less, were stratified by type of primary surgery and residual disease, treatment center, and age; then randomly assigned to one of the two 21-day intravenous regimens. Patients in arm 1 (n = 409) were administered four cycles of cisplatin 50 mg/m(2) on day 1 and topotecan 0.75 mg/m(2) on days 1-5, then four cycles of paclitaxel 175 mg/m(2) over 3 hours on day 1 followed by carboplatin (area under the curve = 5) on day 1. Patients in arm 2 (n = 410) were given paclitaxel plus carboplatin as in arm 1 for eight cycles. We compared progression-free survival (PFS), overall survival, and cancer antigen-125 normalization rates in the two treatment arms. A stratified log-rank test was used to assess the primary endpoint, PFS. All statistical tests were two-sided. A total of 819 patients were randomly assigned. At baseline, the median age of the patients was 57 years (range = 28-78); 81% had received debulking surgery, and of these, 55% had less than 1 cm residual disease; 66% of patients were stage III and 388 (47.4%) patients had measurable disease. After a median follow-up of 43 months, 650 patients had disease progression or died without documented progression and 406 had died. Patients in arm 1 had more hematological toxicity and hospitalizations than patients in arm 2; PFS was 14.6 months in arm 1 vs 16.2 months in arm 2 (hazard ratio = 1.10, 95% confidence interval = 0.94 to 1.28, P = .25). Among patients with elevated baseline cancer antigen-125, fewer in arm 1 than in arm 2 had levels return to normal by 3 months after random assignment (51.6% vs 63.3%, P = .007) Topotecan and cisplatin, followed by carboplatin and paclitaxel, were more toxic than carboplatin and

  7. Change detection studies of Sagar Island, India, using Indian Remote Sensing Satellite 1C linear imaging self-scan sensor III data

    Digital Repository Service at National Institute of Oceanography (India)

    DineshKumar, P.K.; Gopinath, G.; Laluraj, C.M.; Seralathan, P.; Mitra, D.

    Research 23 6 1498–1502 West Palm Beach, Florida November 2007 Change Detection Studies of Sagar Island, India, using Indian Remote Sensing Satellite 1C Linear Imaging Self-Scan Sensor III Data P.K. Dinesh Kumar † , Girish Gopinath ‡ , C.M. Laluraj † , P...-Scan Sensor III data. Journal of Coastal Research, 23(6), 1498–1502. West Palm Beach (Florida), ISSN 0749-0208. The coastal zone of Sagar Island, India, is subjected to various cyclic and random processes that continuously modify the region. The shoreline...

  8. Are active and passive smoking associated with cardiometabolic risk factors in adolescents? The CASPIAN-III Study.

    Science.gov (United States)

    Kelishadi, Roya; Noori, Atefeh; Qorbani, Mostafa; Rahimzadeh, Shadi; Djalalinia, Shirin; Shafiee, Gita; Motlagh, Mohammad Esmaeil; Ardalan, Gelayol; Ansari, Hossein; Asayesh, Hamid; Ahadi, Zeinab; Heshmat, Ramin

    2016-08-01

    Smoking is an important risky behavior in adolescents worldwide. Active and passive smoking have adverse health effects at public and individual levels. This study aimed to evaluate the association of active and passive smoking with cardiometabolic risk factors in a national sample of Iranian adolescents. Participants consisted of 5625 students, aged 10-18 years, studied in the third survey of a national school-based surveillance system. Participants were classified into three groups based on smoking pattern: active smoker, passive smoker, and exposure to smoke (active or passive or both of them). Considering the Adult Treatment Panel III criteria modified for the paediatric age group, metabolic syndrome (MetS) was defined as the co-existence of three out of five components of abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and depressed high-density cholesterol (HDL-C) levels. The mean (SD) age of participants was 14.7 (2.4) years. Mean level of HDL-C was significantly lower in all types of smoking compared to non-smokers. Low HDL-C and MetS had significant association with active smoking (OR 2.10, 95% CI 1.33-3.31 and OR 5.24, 95% CI 2.41-11.37), passive smoking (OR 1.19, 95% CI 1.01-1.43 and OR 1.79, 95% CI 1.09-2.96), and smoking exposure (OR 1.20, 95% CI 1.01-1.43 and OR 2.02, 95% CI 1.22-3.31), respectively. This study confirms that both smoking and exposure to smoke are associated with an increased risk of MetS and some of the cardiometabolic risk factors in adolescents. Preventive measures against passive smoking should be considered as a health priority in the paediatric age groups.

  9. Repeatability study of replicate crash tests: A signal analysis approach.

    Science.gov (United States)

    Seppi, Jeremy; Toczyski, Jacek; Crandall, Jeff R; Kerrigan, Jason

    2017-10-03

    To provide an objective basis on which to evaluate the repeatability of vehicle crash test methods, a recently developed signal analysis method was used to evaluate correlation of sensor time history data between replicate vehicle crash tests. The goal of this study was to evaluate the repeatability of rollover crash tests performed with the Dynamic Rollover Test System (DRoTS) relative to other vehicle crash test methods. Test data from DRoTS tests, deceleration rollover sled (DRS) tests, frontal crash tests, frontal offset crash tests, small overlap crash tests, small overlap impact (SOI) crash tests, and oblique crash tests were obtained from the literature and publicly available databases (the NHTSA vehicle database and the Insurance Institute for Highway Safety TechData) to examine crash test repeatability. Signal analysis of the DRoTS tests showed that force and deformation time histories had good to excellent repeatability, whereas vehicle kinematics showed only fair repeatability due to the vehicle mounting method for one pair of tests and slightly dissimilar mass properties (2.2%) in a second pair of tests. Relative to the DRS, the DRoTS tests showed very similar or higher levels of repeatability in nearly all vehicle kinematic data signals with the exception of global X' (road direction of travel) velocity and displacement due to the functionality of the DRoTS fixture. Based on the average overall scoring metric of the dominant acceleration, DRoTS was found to be as repeatable as all other crash tests analyzed. Vertical force measures showed good repeatability and were on par with frontal crash barrier forces. Dynamic deformation measures showed good to excellent repeatability as opposed to poor repeatability seen in SOI and oblique deformation measures. Using the signal analysis method as outlined in this article, the DRoTS was shown to have the same or better repeatability of crash test methods used in government regulatory and consumer evaluation test

  10. Evaluation of the mutagenicity and genotoxic potential of carvacrol and thymol using the Ames Salmonella test and alkaline, Endo III- and FPG-modified comet assays with the human cell line Caco-2.

    Science.gov (United States)

    LLana-Ruiz-Cabello, Maria; Maisanaba, Sara; Puerto, Maria; Prieto, Ana I; Pichardo, Silvia; Jos, Ángeles; Cameán, Ana M

    2014-10-01

    Currently, direct antimicrobial and antioxidant additives derived from essential oils are used in food packaging and are perceived by consumers as low-health-risk compounds. In this study, we investigated the potential mutagenicity and genotoxicity of carvacrol and thymol, major compounds in several essential oils, using the Ames Salmonella test and the alkaline, Endo III- and formamidopyrimidine glycosylase (FPG)-modified comet assays, respectively. Thymol did not show any mutagenic activity at any concentration assayed (0-250 μM), whereas carvacrol exhibited mutagenic potential, displaying greater activity in presence of the metabolic fraction (29-460 μM). The genotoxic effects were evaluated in the human colon carcinoma cell line Caco-2, and the standard comet assay revealed that neither carvacrol (0-460 μM) nor thymol (0-250 μM) had any affects at 24 and 48 h. The FPG-modified comet assay showed that the highest concentration of carvacrol (460 μM) caused DNA damage, indicating damage to the purine bases. These results should be used to identify the appropriate concentrations of carvacrol and thymol as additives in food packaging. Moreover, further studies are necessary to explore the safety and/or the toxicity mechanisms of these compounds. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. California Diploma Project Technical Report III: Validity Study--Validity Study of the Health Sciences and Medical Technology Standards

    Science.gov (United States)

    McGaughy, Charis; Bryck, Rick; de Gonzalez, Alicia

    2012-01-01

    This study is a validity study of the recently revised version of the Health Science Standards. The purpose of this study is to understand how the Health Science Standards relate to college and career readiness, as represented by survey ratings submitted by entry-level college instructors of health science courses and industry representatives. For…

  12. [Malignant hyperthermia. III. Progress report on serum CK activity, questionable screening test, effect of dantrolene in family members with a hereditary disposition].

    Science.gov (United States)

    Plötz, J

    1983-04-01

    18 members of a MH prone family have been studied to determine the value of various clinical methods which might be helpful in detecting the disposition. Tests included serum levels of CK over a period of 3 years, and of potassium, the influences of muscle provocation and pretreatment with dantrolene, concentration of cholesterol in erythrocytes and cholinesterase (activity and genotype). The results show relative constant measurements of the enzyme; there was, however, no evidence of any other reliable method in assessing the disposition.

  13. Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy

    DEFF Research Database (Denmark)

    Bellmunt, Joaquim; von der Maase, Hans; Mead, Graham M

    2012-01-01

    The combination of gemcitabine plus cisplatin (GC) is a standard regimen in patients with locally advanced or metastatic urothelial cancer. A phase I/II study suggested that a three-drug regimen that included paclitaxel had greater antitumor activity and might improve survival....

  14. Spectrochemical study the effect of high energetic ionization radiation on Ru(III, Pd(II and Hg(II complexes

    Directory of Open Access Journals (Sweden)

    Samar A. Aly

    2017-04-01

    Thermal studies of these chelates before and after γ-irradiation stable that the complexes of Ru(III and Pd (II after γ-irradiation are more thermal show than Hg(II complexes before and after γ-irradiation.

  15. High-vs low-dose cytarabine combined with interferon alfa in patients with first chronic phase chronic myeloid leukemia. A prospective randomized phase III study

    NARCIS (Netherlands)

    Deenik, W.; van der Holt, B.; Verhoef, G. E. G.; Schattenberg, A. V. M. B.; Verdonck, L. F.; Daenen, S. M. G. J.; Zachee, P.; Westveer, P. H. M.; Smit, W. M.; Wittebol, S.; Schouten, H. C.; Lowenberg, B.; Ossenkoppele, G. J.; Cornelissen, J. J.

    A prospective randomized phase III study was performed to evaluate whether intensified cytarabine would induce a higher response rate and longer event-free interval as compared to low-dose cytarabine in chronic myeloid leukemia (CML). One hundred and eighteen patients with CML in early chronic phase

  16. High-vs low-dose cytarabine combined with interferon alfa in patients with first chronic phase chronic myeloid leukemia : A prospective randomized phase III study

    NARCIS (Netherlands)

    Deenik, W.; Holt, B. van der; Verhoef, G.E.; Schattenberg, A.V.M.B.; Verdonck, L.F.; Daenen, S.M.G.J.; Zachee, P.; Westveer, P.H.; Smit, W.M.; Wittebol, S.; Schouten, H.C.; Lowenberg, B.; Ossenkoppele, G.J.; Cornelissen, J.J.L.M.

    2007-01-01

    A prospective randomized phase III study was performed to evaluate whether intensified cytarabine would induce a higher response rate and longer event-free interval as compared to low-dose cytarabine in chronic myeloid leukemia (CML). One hundred and eighteen patients with CML in early chronic phase

  17. Mössbauer study of a tetrakis (pentafluorophenyl porphyrin iron (III chloride in comparison with the fluorine unsubstituted analogue

    Directory of Open Access Journals (Sweden)

    Kaczmarzyk Tomasz

    2015-03-01

    Full Text Available Mössbauer investigations, in association with density functional theory (DFT calculations, have been conducted for the molecular and electronic structures of iron (III [tetrakis (pentafluorophenyl] porphyrin chloride [(F20TPPFe:Cl], as a Fe(III-tetraphenylporphyrin complex containing chloride axial ligand and substituted hydrogen atoms by fluorine ones in the four phenyl rings, in comparison with its fluorine unsubstituted analogue [(TPPFe:Cl]. It was found that the parameters of Mössbauer spectra of both complexes are close to one another, and correspond to the high-spin state of Fe(III ions, but they show the different temperature dependence and the quadrupole doublets in Mössbauer spectra show different asymmetry at low temperatures. Results of DFT calculations are analyzed in the light of catalytic activity of the halogenated complex.

  18. The CPT Reading Comprehension Test: A Validity Study.

    Science.gov (United States)

    Napoli, Anthony R.; Raymond, Lanette A.; Coffey, Cheryl A.; Bosco, Diane M.

    1998-01-01

    Describes a study done at Suffolk County Community College (New York) that assessed the validity of the College Board's Computerized Placement Test in Reading Comprehension (CPT-R) by comparing test results of 1,154 freshmen with the results of the Degree of Power Reading Test. Results confirmed the CPT-R's reliability in identifying basic…

  19. 2-D Model Test Study of the Suape Breakwater, Brazil

    DEFF Research Database (Denmark)

    Andersen, Thomas Lykke; Burcharth, Hans F.; Sopavicius, A.

    This report deals with a two-dimensional model test study of the extension of the breakwater in Suape, Brazil. One cross-section was tested for stability and overtopping in various sea conditions. The length scale used for the model tests was 1:35. Unless otherwise specified all values given...

  20. Pavement Subgrade Performance Study in the Danish Road Testing Machine

    DEFF Research Database (Denmark)

    Ullidtz, Per; Ertman Larsen, Hans Jørgen

    1997-01-01

    Most existing pavement subgrade criteria are based on the AASHO Road Test, where only one material was tested and for only one climatic condition. To study the validity of these criteria and to refine the criteria a co-operative research program entitled the "International Pavement Subgrade...... Performance Study" was sponsored by the FHWA with American, Finnish and Danish partners. This paper describes the first test series which was carried out in the Danish Road Testing Machine (RTM).The first step in this program is a full scale test on an instrumented pavement in the Danish Road Testing Machine...... deformation of the pavement surface. A simple model describing the plastic strain has been developed.The test showed that currently used subgrade strain criteria are conservative if used with the measured strains in the subgrade. If used with strains calculated from FWD tests using linear elastic theory...

  1. Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas.

    Science.gov (United States)

    da Fonseca, Clovis Orlando; Schwartsmann, Gilberto; Fischer, Juliana; Nagel, Janaína; Futuro, Débora; Quirico-Santos, Thereza; Gattass, Cerli Rocha

    2008-09-01

    Activation of the p21-ras signaling pathway from aberrantly expressed receptors promotes the growth of malignant human astrocytomas. Perillyl alcohol has shown to have both chemopreventive and chemotherapeutic activities in preclinical studies. The underlying action mechanism(s) of POH has yet to be delineated but may involve effects on the TGF-beta and/or the Ras signaling pathways. The intranasal delivery allows drugs that do not cross the BBB to enter the CNS; moreover, it eliminates the need for systemic delivery, thereby reducing unwanted systemic side effects. We are conducting a phase I/II study to evaluate the antitumoral activity of POH intranasal delivery in a 4x daily schedule in patients with recurrent MG. The objective was to determine PFS at 6 months and the safety for POH in adult patients who failed conventional treatment. Assessments were performed every 27 days. Thirty-seven patients with progressive disease after prior surgery, radiotherapy, and at least temozolomide-based chemotherapy were enrolled, 29 of whom had GBM, 5 who had anaplastic astrocytoma, and 3 had AO. One patient (3.4%) with GBM and 1 patient (33.3%) with AO achieved partial response; 13 patients (44.8%) with GBM, 3 patients (60%) with AA, and 1 (33.3%) with AO achieved stable disease; 15 (51.7%) patients with GBM, 2 (40%) patients with AA, and 1 (33.3%) with AO showed progressive disease. Progression-free survival (partial response and stable disease) was 48.2% for patients with GBM, 60% for patients with AA, and 66.6% for patients with AO. There were no toxicity events. Perillyl alcohol is well tolerated and regression of tumor size in some patients is suggestive of antitumor activity. This work discusses POH intranasal delivery as a potential adjuvant therapeutic strategy for patients with malignant gliomas.

  2. Resource Use and Costs of Dengue: Analysis of Data from Phase III Efficacy Studies of a Tetravalent Dengue Vaccine.

    Science.gov (United States)

    El Fezzazi, Hanna; Branchu, Marie; Carrasquilla, Gabriel; Pitisuttithum, Punnee; Perroud, Ana Paula; Frago, Carina; Coudeville, Laurent

    2017-12-01

    A tetravalent dengue vaccine (CYD-TDV) has recently been approved in 12 countries in southeast Asia and Latin America for individuals aged 9-45 years or 9-60 years (age indication approvals vary by country) living in endemic areas. Data on utilization of medical and nonmedical resources as well as time lost from school and work were collected during the active phase of two phase III efficacy studies performed in 10 countries in the Asia-Pacific region and Latin America (NCT01373281; NCT01374516). We compared dengue-related resource utilization and costs among vaccinated and nonvaccinated participants. Country-specific unit costs were derived from available literature. There were 901 virologically confirmed dengue episodes among participants aged ≥ 9 years ( N = 25,826): corresponding to 373 episodes in the CYD-TDV group ( N = 17,230) and 528 episodes in the control group ( N = 8,596). Fewer episodes in the CYD-TDV group resulted in hospitalization than in the control group (7.0% versus 13.3%; P = 0.002), but both had a similar average length of stay of 4 days. Overall, a two-thirds reduction in resource consumption and missed school/work days was observed in the CYD-TDV group relative to the control group. The estimated direct and indirect cost (2014 I$) associated with dengue episodes per participant in the CYD-TDV group was 73% lower than in the control group (I$6.72 versus I$25.08); representing a saving of I$I8.36 (95% confidence interval [CI]:17.05-19.78) per participant with vaccination. This is the first study providing information on dengue costs among vaccinated individuals and direct confirmation that vaccination has the potential to reduce dengue illness costs.

  3. Using the T-scan III system to analyze occlusal function in mandibular reconstruction patients: A pilot study

    Directory of Open Access Journals (Sweden)

    Chao-Wei Liu

    2015-02-01

    Full Text Available Background: This study was designed to analyze the post-rehabilitation occlusal function of subjects treated with complex mandibular resection and subsequently rehabilitated with fibula osteoseptocutaneous flaps, dental implants, and fixed prostheses utilizing the T-scan system. Methods: Ten mandibular complex resection cases that adopted fibula osteoseptocutaneous flaps, dental implants, and fixed prostheses to reconstruct occlusal function were analyzed. The mandibular reconstructions were divided into three groups based on size: full mandibular reconstructions, mandibular reconstructions larger than half of the arch, and mandibular reconstructions smaller than half of the arch. The T-scan III system was used to measure maximum occlusal force, occlusal time, anterior-posterior as well as left-right occlusal force asymmetries, and anterior-posterior as well as left-right asymmetrical locations of occlusal centers. Results: Subjects with larger mandibular reconstructions and dental implants with fixed partial dentures demonstrated decreased average occlusal force; however, the difference did not reach the statistically significant level (p > 0.05. The most significant asymmetry of occlusal center location occurred among subjects with mandibular reconstructed areas larger than half of the mandibular arch. Conclusions: Comparison of the parameters of T-scan system used to analyze the occlusal function showed that the occlusal force was not an objective reference. Measurements of the location of the occlusal center appeared more repeatable, and were less affected by additional factors. The research results of this study showed that the size of a reconstruction did not affect the occlusal force after reconstruction and larger reconstructed areas did not decrease the average occlusal force. The most significant parameter was left and right asymmetry of the occlusion center (LROC and was measured in subjects with reconstruction areas larger than half

  4. Serum type III procollagen peptide in patients with Pneumocystis carinii infection. The Copenhagen-Amsterdam PCP-Prednisolone Study Group

    DEFF Research Database (Denmark)

    Bentsen, K D; Nielsen, T L; Eaftinck Schattenkerk, J K

    1993-01-01

    Inflammation may play a central role in the pathogenesis of HIV-related Pneumocystis carinii pneumonia (PCP). Serum levels of the amino-terminal propeptide of Type III procollagen (PIIINP) reflect inflammatory activity in granulation tissue and in chronic rheumatic and liver disorders. To investi......Inflammation may play a central role in the pathogenesis of HIV-related Pneumocystis carinii pneumonia (PCP). Serum levels of the amino-terminal propeptide of Type III procollagen (PIIINP) reflect inflammatory activity in granulation tissue and in chronic rheumatic and liver disorders...

  5. Six-month follow-up multicenter prospective study of 368 patients, phototypes III to V, on epilation efficacy using an 810-nm diode laser at low fluence.

    Science.gov (United States)

    Royo, Josefina; Urdiales, Fernándo; Moreno, Javier; Al-Zarouni, Marwan; Cornejo, Paloma; Trelles, Mario A

    2011-03-01

    Laser hair removal is currently a popular cosmetic procedure. Traditional high-fluence laser treatment for hair elimination is associated with discomfort and adverse events and it is restricted to low phototype skins. A multicenter study of hair epilation with low fluences and high repetition pulse rate using an 810-nm diode laser was carried out on 368 patients (phototypes III to V) to test its efficacy in a 6-month follow-up after five treatments on the face and various body areas. Objective and subjective assessment as well as histologies show a high index of patient satisfaction due to high efficacy of hair elimination, also proved histologically by the damage observed at hair structure level. Results obtained a high degree of patient satisfaction and a low index of adverse events. Laser epilation was well accepted regarding discomfort and was also complication-free for dark and tanned skins. Treatment is easy to conduct and requires adapting the movement of the hand-piece to a constant speed in order to achieve high-energy deposit on tissue avoiding risks of burning.

  6. A phase I/II study of the Janus kinase (JAK)1 and 2 inhibitor ruxolitinib in patients with relapsed or refractory acute myeloid leukemia.

    Science.gov (United States)

    Pemmaraju, Naveen; Kantarjian, Hagop; Kadia, Tapan; Cortes, Jorge; Borthakur, Gautam; Newberry, Kate; Garcia-Manero, Guillermo; Ravandi, Farhad; Jabbour, Elias; Dellasala, Sara; Pierce, Sherry; Verstovsek, Srdan

    2015-03-01

    Ruxolitinib is a potent and specific JAK1/JAK2 inhibitor recently approved for the treatment of myelofibrosis. We conducted a single-center phase I/II clinical study testing 3 dose levels (50 mg b.i.d. [n = 4], 100 mg b.i.d. [n = 5], and 200 mg b.i.d. [n = 18]). We enrolled 27 patients older than 14 years with relapsed or refractory acute myeloid leukemia (n = 26) or acute lymphoid leukemia (n = 1). The median age was 66 (range, 25-88) years. Thirteen patients were evaluable for dose-limiting toxicities. The most common Grade 3 or 4 nonhematologic event was infection (n = 26 events; most frequently pneumonia; 15 of 26; 58%). One patient with multiple relapses after 7 lines of therapy had a CRp at a ruxolitinib dose of 200 mg b.i.d. In this cohort of heavily pretreated patients with relapsed or refractory acute leukemias, ruxolitinib was overall reasonably well tolerated, with 1 patient achieving CRp. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.

    Science.gov (United States)

    Zangwill, Linda M; Ayyagari, Radha; Liebmann, Jeffrey M; Girkin, Christopher A; Feldman, Robert; Dubiner, Harvey; Dirkes, Keri A; Holmann, Matthew; Williams-Steppe, Eunice; Hammel, Naama; Saunders, Luke J; Vega, Suzanne; Sandow, Kevin; Roll, Kathryn; Slight, Rigby; Auerbach, Daniel; Samuels, Brian C; Panarelli, Joseph F; Mitchell, John P; Al-Aswad, Lama A; Park, Sung Chul; Tello, Celso; Cotliar, Jeremy; Bansal, Rajendra; Sidoti, Paul A; Cioffi, George A; Blumberg, Dana; Ritch, Robert; Bell, Nicholas P; Blieden, Lauren S; Davis, Garvin; Medeiros, Felipe A; Ng, Maggie C Y; Das, Swapan K; Palmer, Nicholette D; Divers, Jasmin; Langefeld, Carl D; Freedman, Barry I; Bowden, Donald W; Christopher, Mark A; Chen, Yii-der I; Guo, Xiuqing; Taylor, Kent D; Rotter, Jerome I; Weinreb, Robert N

    2018-01-17

    To describe the study protocol and baseline characteristics of the African Descent and Glaucoma Evaluation Study (ADAGES) III. Cross-sectional, case-control study. Three thousand two hundred sixty-six glaucoma patients and control participants without glaucoma of African or European descent were recruited from 5 study centers in different regions of the United States. Individuals of African descent (AD) and European descent (ED) with primary open-angle glaucoma (POAG) and control participants completed a detailed demographic and medical history interview. Standardized height, weight, and blood pressure measurements were obtained. Saliva and blood samples to provide serum, plasma, DNA, and RNA were collected for standardized processing. Visual fields, stereoscopic disc photographs, and details of the ophthalmic examination were obtained and transferred to the University of California, San Diego, Data Coordinating Center for standardized processing and quality review. Participant gender, age, race, body mass index, blood pressure, history of smoking and alcohol use in POAG patients and control participants were described. Ophthalmic measures included intraocular pressure, visual field mean deviation, central corneal thickness, glaucoma medication use, or past glaucoma surgery. Ocular conditions, including diabetic retinopathy, age-related macular degeneration, and past cataract surgery, were recorded. The 3266 ADAGES III study participants in this report include 2146 AD POAG patients, 695 ED POAG patients, 198 AD control participants, and 227 ED control participants. The AD POAG patients and control participants were significantly younger (both, 67.4 years) than ED POAG patients and control participants (73.4 and 70.2 years, respectively). After adjusting for age, AD POAG patients had different phenotypic characteristics compared with ED POAG patients, including higher intraocular pressure, worse visual acuity and visual field mean deviation, and thinner corneas (all

  8. Extraction Separation of Am(III) and Eu(III) with Thermo-sensitive Gel introducing TPEN Derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Kenji Takeshita [Chemical Resources Laboratory, Tokyo Institute of Technology Nagatsuta, Midori-ku, Yokohama 226-8503 (Japan); Yoshio Nakano [Department of Environment Chemistry and Engineering, Tokyo Institute of Technology Nagatsuta, Midori-ku, Yokohama 226-8502 (Japan); Tatsuro Matsumura [Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency Tokai-mura, Naka-gun, Ibaragi, 319-1195 (Japan); Atsunori Mori [Department of Chemical Science and Engineering, Kobe University Rokkodai-cho, Nada-ku, Kobe, 657-8501 (Japan)

    2008-07-01

    A thermal-swing chromatographic process using a thermo-sensitive gel co-polymerized with NIPA (N-isopropyl-acrylamide) and TPPEN (N,N,N',N'-tetrakis(4-propenyl-oxy-2-pyridyl-methyl)ethylenediamine) was studied for the separation of Am(III) from Eu(III). First, the radiolysis of the TPPEN-NIPA gel was tested by the {gamma}-ray irradiation and the {alpha} nuclide adsorption. The extraction separation of Am(III) was not influenced in the radioactive environment of the proposed process. Next, the TPPEN-NIPA gel was immobilized in porous silica particles and the applicability of the gel-immobilized silica to the proposed process was tested. Am(III) was extracted selectively in the gel-immobilized silica at 5 deg. C and the separation factor of Am(III) over Eu(III) was evaluated to be 3.7. The distribution ratio of Am(III) was reduced to less than 1/20 by increasing temperature from 5 deg. C to 40 deg. C. These results indicate that the TPPEN-NIPA gel is applicable to the thermal-swing chromatographic process for the minor actinide recovery. (authors)

  9. Synthesis, Characterization, and Catalytic Studies of Mn(III-Schiff Base-Dicyanamide Complexes: Checking the Rhombicity Effect in Peroxidase Studies

    Directory of Open Access Journals (Sweden)

    Manuel R. Bermejo

    2017-01-01

    Full Text Available The condensation of 3-methoxy-2-hydroxybenzaldehyde and the diamines 1,2-diphenylendiamine, 1,2-diamine-2-methylpropane and 1,3-propanediamine yielded the dianionic tetradentate Schiff base ligands N,N′-bis(2-hydroxy-4-methoxybenzylidene-1,2-diphenylendiimine (H2L1, N,N′-bis(2-hydroxy-4-methoxybenzylidene-1,2-diamino-2-methylpropane (H2L2 and N,N′-bis(2-hydroxy-4-methoxybenzylidene-1,3-diaminopropane (H2L3 respectively. The organic compounds H2L1 and H2L2 have been characterized by elemental analysis, IR, 1H and 13C NMR spectroscopies and mass spectrometry electrospray (ES. The crystal structure of H2L2 in solid state, solved by X-ray crystallography, is highly conditioned in the solid state by two N-H•••N intramolecular interactions. The synthesis of three new manganese(III complexes 1–3, incorporating these ligands, H2L1–H2L3, and dicyanamide (DCA, is reported. The complexes 1–3 have been physicochemically characterized by elemental analysis, IR and paramagnetic 1H NMR spectroscopy, ESI mass spectrometry, magnetic moment at room temperature and conductivity measurements. Complex 1 has been crystallographically characterized. The X-ray structure shows the self-assembly of the Mn(III-Schiff base-DCA complex through µ-aquo bridges between neighbouring axial water molecules and also by π-π stacking interactions, establishing a dimeric structure. The manganese complexes were also tested as peroxidase mimics for the H2O2-mediated reaction with the water-soluble trap ABTS, showing complexes 1-2 relevant peroxidase activity in contrast with 3. The rhombicity around the metal ion can explain this catalytic behaviour.

  10. Interaction of chromium(III) or chromium(VI) with catalase and its effect on the structure and function of catalase: An in vitro study.

    Science.gov (United States)

    Chen, Linfeng; Zhang, Jing; Zhu, Yaxian; Zhang, Yong

    2018-04-01

    Heavy metal chromium (Cr) poses a severe health risk to humans via food chain contamination. In this study, the interactions of either trivalent chromium (Cr(III)) or hexavalent chromium (Cr(VI)) with catalase (CAT) were investigated via multi-spectroscopic studies and computational simulations. The fluorescence analysis showed that Cr(III) and Cr(VI) quenched the fluorescence of CAT through a dynamic and a static quenching mechanism, respectively. The binding constant of Cr(VI) with CAT was 3.44×10(4)lmol(-1) at 298K. Other detailed binding characterizations of the Cr(VI)-CAT complex were also obtained using spectra analysis and molecular docking. Synchronous fluorescence, UV-vis and circular dichroism (CD) spectral studies showed that either Cr(III) or Cr(VI) induced conformational changes of CAT, but the degree of influence was different. The response of CAT activity to Cr(III) or Cr(VI) was found to be variable depending on their valence states and concentrations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. COMPARISON OF UPPER LIP BITE TEST WITH MODIFIED MALLAMPATI TEST AND THYROMENTAL DISTANCE FOR PREDICTING DIFFICULTY IN ENDOTRACHEAL INTUBATION: A PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Prakash T. S. N

    2016-09-01

    Full Text Available BACKGROUND The significance of difficult or failed tracheal intubation was well recognised as a major cause of morbidity and mortality in anaesthetic practice as per ASA closed claim study. The need to predict potentially difficult tracheal intubation has received more importance, but with limited success. Unanticipated difficult intubation is a risk to patient’s life and a challenge to the skill of the anaesthesiologist. Many anatomical and pathological variables have been identified and have been suggested to be useful in anticipating a difficult airway. These factors have limitations because of wide variations in the incidence of difficult intubation, interobserver variability and inadequate statistical power of the currently measured variables. METHODS After obtaining institutional ethical committee clearance and written informed consent, the present study was conducted in 200 patients aged between 16 yrs. and 65 yrs. at King George Hospital, Andhra Medical College, Visakhapatnam, in the Department of Anaesthesiology. All the 200 patients undergoing elective surgical procedures under general anaesthesia were enrolled in the study. A thorough preanaesthetic evaluation was carried out in all the patients and the procedure was explained in detail to the patients. RESULTS Of the entire two hundred patients, a total of ten patients had difficult intubation, all of them had Cormack-Lehane class III on laryngoscopy. None of them had Cormack-Lehane class IV on laryngoscopy. The incidence of difficult intubation was 5% in the present study. There were no cases of failed intubation. One hundred and eighty seven patients predicted to be easy for intubation by ULBT (i.e. patients who had ULBT class I and II out of whom, however, we encountered difficult intubation in 5 patients. Out of the eight patients predicted to have difficult airway by ULBT III, only one patient had CL III difficult airway and subsequently difficult intubation. CONCLUSIONS MMT

  12. Is kidney function affecting the management of myocardial infarction? A retrospective cohort study in patients with normal kidney function, chronic kidney disease stage III-V, and ESRD.

    Science.gov (United States)

    Saad, Marc; Karam, Boutros; Faddoul, Geovani; Douaihy, Youssef El; Yacoub, Harout; Baydoun, Hassan; Boumitri, Christine; Barakat, Iskandar; Saifan, Chadi; El-Charabaty, Elie; Sayegh, Suzanne El

    2016-01-01

    Patients with chronic kidney disease (CKD) are three times more likely to have myocardial infarction (MI) and suffer from increased morbidity and higher mortality. Traditional and unique risk factors are prevalent and constitute challenges for the standard of care. However, CKD patients have been largely excluded from clinical trials and little evidence is available to guide evidence-based treatment of coronary artery disease in patients with CKD. Our objective was to assess whether a difference exists in the management of MI (ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction) among patients with normal kidney function, CKD stage III-V, and end-stage renal disease (ESRD) patients. We conducted a retrospective cohort study on patients a