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Sample records for tesla fticr mass

  1. Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

    Science.gov (United States)

    Weisbrod, Chad R.; Kaiser, Nathan K.; Syka, John E. P.; Early, Lee; Mullen, Christopher; Dunyach, Jean-Jacques; English, A. Michelle; Anderson, Lissa C.; Blakney, Greg T.; Shabanowitz, Jeffrey; Hendrickson, Christopher L.; Marshall, Alan G.; Hunt, Donald F.

    2017-09-01

    High resolution mass spectrometry is a key technology for in-depth protein characterization. High-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) enables high-level interrogation of intact proteins in the most detail to date. However, an appropriate complement of fragmentation technologies must be paired with FTMS to provide comprehensive sequence coverage, as well as characterization of sequence variants, and post-translational modifications. Here we describe the integration of front-end electron transfer dissociation (FETD) with a custom-built 21 tesla FT-ICR mass spectrometer, which yields unprecedented sequence coverage for proteins ranging from 2.8 to 29 kDa, without the need for extensive spectral averaging (e.g., 60% sequence coverage for apo-myoglobin with four averaged acquisitions). The system is equipped with a multipole storage device separate from the ETD reaction device, which allows accumulation of multiple ETD fragment ion fills. Consequently, an optimally large product ion population is accumulated prior to transfer to the ICR cell for mass analysis, which improves mass spectral signal-to-noise ratio, dynamic range, and scan rate. We find a linear relationship between protein molecular weight and minimum number of ETD reaction fills to achieve optimum sequence coverage, thereby enabling more efficient use of instrument data acquisition time. Finally, real-time scaling of the number of ETD reactions fills during method-based acquisition is shown, and the implications for LC-MS/MS top-down analysis are discussed. [Figure not available: see fulltext.

  2. TG/DTG, FT-ICR Mass Spectrometry, and NMR Spectroscopy Study of Heavy Fuel Oil

    KAUST Repository

    Elbaz, Ayman M.; Abdul Jameel, Abdul Gani; Hourani, Nadim; Emwas, Abdul-Hamid M.; Sarathy, Mani; Roberts, William L.

    2015-01-01

    infusion atmospheric pressure chemical ionization Fourier transform ion cyclotron resonance mass spectrometry (APCI-FTICR MS), high resolution 1H nuclear magnetic resonance (NMR), 13C NMR, and two-dimensional heteronuclear multiple bond correlation (HMBC

  3. MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data

    Science.gov (United States)

    Spraggins, Jeffrey M.; Rizzo, David G.; Moore, Jessica L.; Rose, Kristie L.; Hammer, Neal D.; Skaar, Eric P.; Caprioli, Richard M.

    2015-06-01

    MALDI imaging mass spectrometry is a highly sensitive and selective tool used to visualize biomolecules in tissue. However, identification of detected proteins remains a difficult task. Indirect identification strategies have been limited by insufficient mass accuracy to confidently link ion images to proteomics data. Here, we demonstrate the capabilities of MALDI FTICR MS for imaging intact proteins. MALDI FTICR IMS provides an unprecedented combination of mass resolving power (~75,000 at m/z 5000) and accuracy (differentiate a series of oxidation products of S100A8 ( m/z 10,164.03, -2.1ppm), a subunit of the heterodimer calprotectin, in kidney tissue from mice infected with Staphylococcus aureus. S100A8 - M37O/C42O3 ( m/z 10228.00, -2.6ppm) was found to co-localize with bacterial microcolonies at the center of infectious foci. The ability of MALDI FTICR IMS to distinguish S100A8 modifications is critical to understanding calprotectin's roll in nutritional immunity.

  4. Absorption Mode FT-ICR Mass Spectrometry Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Donald F.; Kilgour, David P.; Konijnenburg, Marco; O' Connor, Peter B.; Heeren, Ronald M.

    2013-12-03

    Fourier transform ion cyclotron resonance mass spectrometry offers the highest mass resolving power for molecular imaging experiments. This high mass resolving power ensures that closely spaced peaks at the same nominal mass are resolved for proper image generation. Typically higher magnetic fields are used to increase mass resolving power. However, a gain in mass resolving power can also be realized by phase correction of the data for absorption mode display. In addition to mass resolving power, absorption mode offers higher mass accuracy and signal-to-noise ratio over the conventional magnitude mode. Here we present the first use of absorption mode for Fourier transform ion cyclotron resonance mass spectrometry imaging. The Autophaser algorithm is used to phase correct each spectrum (pixel) in the image and then these parameters are used by the Chameleon work-flow based data processing software to generate absorption mode ?Datacubes? for image and spectral viewing. Absorption mode reveals new mass and spatial features that are not resolved in magnitude mode and results in improved selected ion image contrast.

  5. SIEMENS ADVANCED QUANTRA FTICR MASS SPECTROMETER FOR ULTRA HIGH RESOLUTION AT LOW MASS

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, W; Laura Tovo, L

    2008-07-08

    The Siemens Advanced Quantra Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometer was evaluated as an alternative instrument to large double focusing mass spectrometers for gas analysis. High resolution mass spectrometers capable of resolving the common mass isomers of the hydrogen isotopes are used to provide data for accurate loading of reservoirs and to monitor separation of tritium, deuterium, and helium. Conventional double focusing magnetic sector instruments have a resolution that is limited to about 5000. The Siemens FTICR instrument achieves resolution beyond 400,000 and could possibly resolve the tritium ion from the helium-3 ion, which differ by the weight of an electron, 0.00549 amu. Working with Y-12 and LANL, SRNL requested Siemens to modify their commercial Quantra system for low mass analysis. To achieve the required performance, Siemens had to increase the available waveform operating frequency from 5 MHz to 40 MHz and completely redesign the control electronics and software. However, they were able to use the previous ion trap, magnet, passive pump, and piezo-electric pulsed inlet valve design. NNSA invested $1M in this project and acquired four systems, two for Y-12 and one each for SRNL and LANL. Siemens claimed a $10M investment in the Quantra systems. The new Siemens Advanced Quantra demonstrated phenomenal resolution in the low mass range. Resolution greater than 400,000 was achieved for mass 2. The new spectrometer had a useful working mass range to 500 Daltons. However, experiments found that a continuous single scan from low mass to high was not possible. Two useful working ranges were established covering masses 1 to 6 and masses 12 to 500 for our studies. A compromise performance condition enabled masses 1 to 45 to be surveyed. The instrument was found to have a dynamic range of about three orders of magnitude and quantitative analysis is expected to be limited to around 5 percent without using complex fitting algorithms

  6. Identification of Reactive and Refractory Components of Dissolved Organic Nitrogen by FT-ICR Mass Spectrometry

    Science.gov (United States)

    Cooper, W. T.; Podgorski, D. C.; Osborne, D. M.; Corbett, J.; Chanton, J.

    2010-12-01

    Dissolved organic nitrogen is an often overlooked but potentially significant bioavailable component of dissolved organic matter. Studies of bulk DON turnover have been reported, but the compositions of the reactive and refractory components of DON are largely unknown. Here we show the unique ability of atmospheric pressure photoionization (APPI) coupled to ultrahigh resolution mass spectrometry to identify the reactive and refractory components of DON. Figure 1 is an isolated 0.30 m/z window from an ultrahigh resolution APPI FT-ICR mass spectrum of DON in surface waters draining an agricultural area in South Florida. Using this optimized, negative-ion APPI strategy we have been able to identify the reactive and refractory components of DON in these nitrogen-rich waters. Similar results were observed with samples from soil porewaters in sedge-dominated fens and sphagnum-dominated bogs within the Glacial Lake Agassiz Peatlands (GLAP) of northern Minnesota. Surprisingly, microbes appear to initially use similar enzymatic pathways to degrade DON and DOC, often with little release of nitrogen. Figure 1. Isolated 0.30 m/z window at nominal mass 432 from negative-ion APPI FT-ICR mass spectrum of DOM from waters draining an agricultural area in South Florida. Peaks marked contain nitrogen.

  7. Molecular Characterization and Reactivity of Dissolved Organic Matter by High Resolution Nanospray Ionization Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS)

    Science.gov (United States)

    Sleighter, R. L.; Hatcher, S. A.; Hatcher, P. G.

    2006-12-01

    The ultrahigh resolving power of FTICR-MS allows for the intense characterization of dissolved organic matter (DOM). DOM is the largest reactive component of the global carbon cycle, and an improved understanding of its composition is necessary to determine the transport and eventual fate of pollutants. The seasonal and spatial variations in DOM composition are investigated by taking surface water samples from five different sampling sites, four times a year. Water sampling begins at the Dismal Swamp in North Carolina, continues north up the Elizabeth River to the Chesapeake Bay, and concludes approximately ten miles off the coast in the Atlantic Ocean. DOM was extracted from the water samples using C18 extraction disks and were prepared in 50:50 methanol:water. Ammonium hydroxide was added prior to nanospray in order to solubilize the DOM as well as to increase the ionization efficiency. The samples were continuously infused into the Apollo II ion source with an Advion TriVersa NanoMate system of a Bruker 12 Tesla Apex QE FTICR-MS with resolving powers exceeding 400,000. All samples were analyzed in negative ion mode and were externally and internally calibrated prior to data analysis. Our DOM mass spectra consist of a multitude of peaks spanning the range of 200-850 m/z. Complexity is apparent from the detection of up to 20 peaks per nominal mass at nearly every mass throughout that range. A molecular formula calculator generated molecular formula matches from which van Krevelen plots were constructed for characterization purposes. A wide range of molecules were observed each containing oxygen, sulfur and nitrogen functional groups. We utilize the van Krevelen diagram to assist in clustering the molecules according to their functional group compositions. To test the hypothesis that formation of adducts to DOM serve to protect peptides from bacterial degradation, microcosm experiments were performed with a small isotopically enriched peptide, GGGR. This peptide

  8. Collisional Activation of Peptide Ions in FT-ICR Mass Spectrometry

    International Nuclear Information System (INIS)

    Laskin, Julia; Futrell, Jean H.

    2003-01-01

    In the last decade characterization of complex molecules, particularly biomolecules became a focus of both fundamental and applied research in mass spectrometry. Most of these studies utilize tandem mass spectrometry (MS/MS) for obtaining structural information for complex molecules. . Tandem mass spectrometry (MS/MS) typically involves the mass selection of a primary ion, its activation by collision or photon excitation, unimolecular decay into fragment ions characteristic of the ion structure and its internal excitation, and mass analysis of the fragment ions. Although the fundamental principles of tandem mass spectrometry of relatively small molecules are fairly well understood, our understanding of the activation and fragmentation of large molecules is much more primitive. For small ions a single energetic collision is sufficient to dissociate the ion but this is not the case for complex molecules. For large ions two fundamental limits severely constrain fragmentation in tandem mass spectrometry. First the center-of-mass collision energy?the absolute upper limit of energy transfer in a collision process?decreases with increasing mass of the projectile ion for fixed ion kinetic energy and neutral mass. Secondly, the dramatic increase in density of states with increasing internal degrees of freedom of the ion decreases the rate of dissociation by many orders of magnitude at a given internal energy. Consequently most practical MS/MS experiments with complex ions involve multiple collision activation (MCA-CID), multi-photon activation or surface-induced dissociation (SID). This review is focused on what has been learned in recent research studies concerned with fundamental aspects of MCA-CID and SID of model peptides with emphasis on experiments carried out using Fourier transform ion cyclotron resonance mass spectrometers (FT-ICR MS). These studies provide the first quantitative comparison of gas-phase multiple-collision activation and SID of peptide ions

  9. 'Collisional Activation of Peptide Ions in FT-ICR Mass Spectrometry'

    International Nuclear Information System (INIS)

    Laskin, Julia; Futrell, Jean H.

    2003-01-01

    In the last decade characterization of complex molecules, particularly biomolecules became a focus of both fundamental and applied research in mass spectrometry. Most of these studies utilize tandem mass spectrometry (MS/MS) for obtaining structural information for complex molecules. . Tandem mass spectrometry (MS/MS) typically involves the mass selection of a primary ion, its activation by collision or photon excitation, unimolecular decay into fragment ions characteristic of the ion structure and its internal excitation, and mass analysis of the fragment ions. Although the fundamental principles of tandem mass spectrometry of relatively small molecules are fairly well understood, our understanding of the activation and fragmentation of large molecules is much more primitive. For small ions a single energetic collision is sufficient to dissociate the ion but this is not the case for complex molecules. For large ions two fundamental limits severely constrain fragmentation in tandem mass spectrometry. First the center-of-mass collision energy?the absolute upper limit of energy transfer in a collision process?decreases with increasing mass of the projectile ion for fixed ion kinetic energy and neutral mass. Secondly, the dramatic increase in density of states with increasing internal degrees of freedom of the ion decreases the rate of dissociation by many orders of magnitude at a given internal energy. Consequently most practical MS/MS experiments with complex ions involve multiple collision activation (MCA-CID), multi-photon activation or surface-induced dissociation (SID). This review is focused on what has been learned in recent research studies concerned with fundamental aspects of MCA-CID and SID of model peptides with emphasis on experiments carried out using Fourier transform ion cyclotron resonance mass spectrometers (FT-ICR MS). These studies provide the first quantitative comparison of gas-phase multiple-collision activation and SID of peptide ions

  10. 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer Greatly Expands Mass Spectrometry Toolbox

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, Jared B.; Lin, Tzu-Yung; Leach, Franklin E.; Tolmachev, Aleksey V.; Tolić, Nikola; Robinson, Errol W.; Koppenaal, David W.; Paša-Tolić, Ljiljana

    2016-10-12

    We provide the initial performance evaluation of a 21 Tesla Fourier transform ion cyclotron resonance mass spectrometer operating at the Environmental Molecular Sciences Laboratory at Pacific Northwest National Laboratory. The spectrometer constructed for the 21T system employs a commercial dual linear ion trap mass spectrometer coupled to a FTICR spectrometer designed and built in-house. Performance gains from moving to higher magnetic field strength are exemplified by the measurement of peptide isotopic fine structure, complex natural organic matter mixtures, and large proteins. Accurate determination of isotopic fine structure was demonstrated for doubly charged substance P with minimal spectral averaging, and 8,158 molecular formulas assigned to Suwannee River Fulvic Acid standard with RMS error of 10 ppb. We also demonstrated superior performance for intact proteins; namely, broadband isotopic resolution of the entire charge state distribution of apotransferrin (78 kDa) and facile isotopic resolution of monoclonal antibody under a variety of acquisition parameters (e.g. 6 s time-domains with absorption mode processing yielded resolution of approximately 1M at m/z =2,700).

  11. High-Throughput Proteomics Using High Efficiency Multiple-Capillary Liquid Chromatography With On-Line High-Performance ESI FTICR Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Yufeng (BATTELLE (PACIFIC NW LAB)); Tolic, Nikola (BATTELLE (PACIFIC NW LAB)); Zhao, Rui (ASSOC WESTERN UNIVERSITY); Pasa Tolic, Ljiljana (BATTELLE (PACIFIC NW LAB)); Li, Lingjun (Illinois Univ Of-Urbana/Champa); Berger, Scott J.(ASSOC WESTERN UNIVERSITY); Harkewicz, Richard (BATTELLE (PACIFIC NW LAB)); Anderson, Gordon A.(BATTELLE (PACIFIC NW LAB)); Belov, Mikhail E.(BATTELLE (PACIFIC NW LAB)); Smith, Richard D.(BATTELLE (PACIFIC NW LAB))

    2000-12-01

    We report on the design and application of a high-efficiency multiple-capillary liquid chromatography (LC) system for high-throughput proteome analysis. The multiple-capillary LC system was operated at the pressure of 10,000 psi using commercial LC pumps to deliver the mobile phase and newly developed passive feedback valves to switch the mobile phase flow and introduce samples. The multiple-capillary LC system was composed of several serially connected dual-capillary column devices. The dual-capillary column approach was designed to eliminate the time delay for regeneration (or equilibrium) of the capillary column after its use under the mobile phase gradient condition (i.e. one capillary column was used in separation and the other was washed using mobile phase A). The serially connected dual-capillary columns and ESI sources were operated independently, and could be used for either''backup'' operation or with other mass spectrometer(s). This high-efficiency multiple-capillary LC system uses switching valves for all operations and is highly amenable to automation. The separations efficiency of dual-capillary column device, optimal capillary dimensions (column length and packed particle size), suitable mobile phases for electrospray, and the capillary re-generation were investigated. A high magnetic field (11.5 tesla) Fourier transform ion cyclotron resonance (FTICR) mass spectrometer was coupled on-line with this high-efficiency multiple-capillary LC system through an electrospray ionization source. The capillary LC provided a peak capacity of {approx}600, and the 2-D capillary LC-FTICR provided a combined resolving power of > 6 x 10 7 polypeptide isotopic distributions. For yeast cellular tryptic digests, > 100,000 polypeptides were typically detected, and {approx}1,000 proteins can be characterized in a single run.

  12. TG/DTG, FT-ICR Mass Spectrometry, and NMR Spectroscopy Study of Heavy Fuel Oil

    KAUST Repository

    Elbaz, Ayman M.

    2015-11-12

    There is an increasing interest in the comprehensive study of heavy fuel oil (HFO) due to its growing use in furnaces, boilers, marines, and recently in gas turbines. In this work, the thermal combustion characteristics and chemical composition of HFO were investigated using a range of techniques. Thermogravimetric analysis (TGA) was conducted to study the nonisothermal HFO combustion behavior. Chemical characterization of HFO was accomplished using various standard methods in addition to direct infusion atmospheric pressure chemical ionization Fourier transform ion cyclotron resonance mass spectrometry (APCI-FTICR MS), high resolution 1H nuclear magnetic resonance (NMR), 13C NMR, and two-dimensional heteronuclear multiple bond correlation (HMBC) spectroscopy. By analyzing thermogravimetry and differential thermogravimetry (TG/DTG) results, three different reaction regions were identified in the combustion of HFO with air, specifically, low temperature oxidation region (LTO), fuel deposition (FD), and high temperature oxidation (HTO) region. At the high end of the LTO region, a mass transfer resistance (skin effect) was evident. Kinetic analysis in LTO and HTO regions was conducted using two different kinetic models to calculate the apparent activation energy. In both models, HTO activation energies are higher than those for LTO. The FT-ICR MS technique resolved thousands of aromatic and sulfur containing compounds in the HFO sample and provided compositional details for individual molecules of three major class species. The major classes of compounds included species with one sulfur atom (S1), with two sulfur atoms (S2), and purely hydrocarbons (HC). The DBE (double bond equivalent) abundance plots established for S1 and HC provided additional information on their distributions in the HFO sample. The 1H NMR and 13C NMR results revealed that nearly 59% of the 1H nuclei were distributed as paraffinic CH2 and 5% were in aromatic groups. Nearly 21% of 13C nuclei were

  13. Environmental Forensics: Molecular Insight into Oil Spill Weathering Helps Advance High Magnetic Field FT-ICR Mass Spectrometry

    Science.gov (United States)

    McKenna, Amy

    2013-03-01

    The depletion of terrestrial global oil reserves has shifted oil exploration into offshore and ultra-deep water (> 5000 ft) oil reserves to meet global energy demands. Deep water reservoirs are currently in production in many parts of the world, including the Gulf of Mexico, but production is complicated by the water depth and thick salt caps that challenge reservoir characterization / production. The explosion aboard the Deepwater Horizon in April 2010 resulted in an estimated total release of ~5 million barrels (BP claims that they collected ~1M barrels, for a net release of 4 M) of light, sweet crude oil into the Gulf of Mexico and shifted attention toward the environmental risks associated with offshore oil production. The growing emphasis on deep water and ultra-deep water oil production poses a significant environmental threat, and increased regulations require that oil companies minimize environmental impact to prevent oil spills, and mitigate environmental damage when spills occur. Every oil spill is unique. The molecular transformations that occur to petroleum after contact with seawater depend on the physical and chemical properties of the spilled oil, environmental conditions, and deposition environment. Molecular-level knowledge of the composition, distribution, and total mass of released hydrocarbons is essential to disentangle photo- and bio-degradation, source identification, and long-term environmental impact of hydrocarbons released into the environment. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) is unsurpassed in its ability to characterize complex mixtures at the level of elemental composition assignment. Only FT-ICR mass spectrometry can routinely achieve the required minimum resolving power necessary to elucidate molecular-level characterization of crude oil. Conversely, the spectral complexity of petroleum facilitates identification of systematic errors in the accumulation, transfer, excitation, and detection

  14. High field FT-ICR mass spectrometry for molecular characterization of snow board from Moscow regions.

    Science.gov (United States)

    Mazur, Dmitry M; Harir, Mourad; Schmitt-Kopplin, Philippe; Polyakova, Olga V; Lebedev, Albert T

    2016-07-01

    High field Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry analysis of eight snow samples from Moscow city allowed us to identify more than 2000 various elemental compositions corresponding to regional air pollutants. The hierarchical cluster analysis (HCA) of the data showed good concordance of three main groups of samples with the main wind directions. The North-West group (A1) is represented by several homologous CHOS series of aliphatic organic aerosols. They may form as a result of enhanced photochemical reactions including oxidation of hydrocarbons with sulfonations due to higher amount of SO2 emissions in the atmosphere in this region. Group A2, corresponding to the South-East part of Moscow, contains large amount of oxidized hydrocarbons of different sources that may form during oxidation in atmosphere. These hydrocarbons appear correlated to emissions from traffic, neighboring oil refinery, and power plants. Another family of compounds specific for this region involves CHNO substances formed during oxidation processes including NOx and NO3 radical since emissions of NOx are higher in this part of the city. Group A3 is rich in CHO type of compounds with high H/C and low O/C ratios, which is characteristic of oxidized hydrocarbon-like organic aerosol. CHNO types of compounds in A3 group are probably nitro derivatives of condensed hydrocarbons such as PAH. This non-targeted profiling revealed site specific distribution of pollutants and gives a chance to develop new strategies in air quality control and further studies of Moscow environment. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis.

    Science.gov (United States)

    Spraggins, Jeffrey M; Rizzo, David G; Moore, Jessica L; Noto, Michael J; Skaar, Eric P; Caprioli, Richard M

    2016-06-01

    MALDI imaging mass spectrometry is a powerful analytical tool enabling the visualization of biomolecules in tissue. However, there are unique challenges associated with protein imaging experiments including the need for higher spatial resolution capabilities, improved image acquisition rates, and better molecular specificity. Here we demonstrate the capabilities of ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR IMS platforms as they relate to these challenges. High spatial resolution MALDI-TOF protein images of rat brain tissue and cystic fibrosis lung tissue were acquired at image acquisition rates >25 pixels/s. Structures as small as 50 μm were spatially resolved and proteins associated with host immune response were observed in cystic fibrosis lung tissue. Ultra-high speed MALDI-TOF enables unique applications including megapixel molecular imaging as demonstrated for lipid analysis of cystic fibrosis lung tissue. Additionally, imaging experiments using MALDI FTICR IMS were shown to produce data with high mass accuracy (z 5000) for proteins up to ∼20 kDa. Analysis of clear cell renal cell carcinoma using MALDI FTICR IMS identified specific proteins localized to healthy tissue regions, within the tumor, and also in areas of increased vascularization around the tumor. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Comprehensive list of metabolites measured by DI-FTICR mass spectrometry in thyme plants with contrasting tolerance to drought

    Directory of Open Access Journals (Sweden)

    Parviz Moradi

    2017-06-01

    Full Text Available This article contains data related to the main research entitled “Metabolomic approach reveals the biochemical mechanisms underlying drought stress tolerance in Thyme” (Moradi et al., 2017 [1]. Two thyme populations with contrasting drought tolerance were subjected to long term water deficit. Leaf samples harvested at the end of stress period and bi-phasic extraction carried out to get polar and non-polar fractions. Extracted samples were analyzed through Direct Infusion FT-ICR mass spectrometry. Date files comprise of four separate tables for all the putatively identified metabolites and their intensities in watered and droughted plants. P-values beside each m/z values indicate significances of difference between peak intensities of stressed and control conditions.

  17. Measuring the Higgs mass at TESLA

    International Nuclear Information System (INIS)

    Garcia-Abia, P.; Lohmann, W.; Raspereza, A.

    2001-01-01

    We report on the accuracy of the measurement of the Higgs boson mass that would be achieved in a linear collider operating at a center-of-mass energy of 350 GeV, assuming an integrated luminosity of 500 fb-1. For that we have exploited the exclusive Higgs decays into b quarks and W bosons. The Higgs mass is determined with an accuracy of about 40 MeV for m H =120 GeV and 80 MeV for m H =180 GeV

  18. Oligomers, organosulfates, and nitrooxy organosulfates in rainwater identified by ultra-high resolution electrospray ionization FT-ICR mass spectrometry

    Directory of Open Access Journals (Sweden)

    K. E. Altieri

    2009-04-01

    Full Text Available Wet deposition is an important removal mechanism for atmospheric organic matter, and a potentially important input for receiving ecosystems, yet less than 50% of rainwater organic matter is considered chemically characterized. Precipitation samples collected in New Jersey, USA, were analyzed by negative ion ultra-high resolution electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS. Elemental compositions of 552 unique molecular species were determined in the mass range 50–500 Da in the rainwater. Four main groups of organic compounds were identified: compounds containing carbon, hydrogen, and oxygen (CHO only, sulfur (S containing CHOS compounds, nitrogen (N containing CHON compounds, and S- and N- containing CHONS compounds. Organic acids commonly identified in precipitation were detected in the rainwater. Within the four main groups of compounds detected in the rainwater, oligomers, organosulfates, and nitrooxy-organosulfates were assigned based on elemental formula comparisons. The majority of the compounds identified are products of atmospheric reactions and are known contributors to secondary organic aerosol (SOA formed from gas phase, aerosol phase, and in-cloud reactions in the atmosphere. It is suggested that the large uncharacterized component of SOA is the main contributor to the large uncharacterized component of rainwater organic matter.

  19. Mass measurements on neutron-deficient nuclides at SHIPTRAP and commissioning of a cryogenic narrow-band FT-ICR mass spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Ferrer Garcia, R.

    2007-07-01

    The dissertation presented here deals with high-precision Penning trap mass spectrometry on short-lived radionuclides. Owed to the ability of revealing all nucleonic interactions, mass measurements far off the line of {beta}-stability are expected to bring new insight to the current knowledge of nuclear properties and serve to test the predictive power of mass models and formulas. In nuclear astrophysics, atomic masses are fundamental parameters for the understanding of the synthesis of nuclei in the stellar environments. This thesis presents ten mass values of radionuclides around A=90 interspersed in the predicted rp-process pathway. Six of them have been experimentally determined for the first time. The measurements have been carried out at the Penning-trap mass spectrometer SHIPTRAP using the destructive time-of-flight ion-cyclotron-resonance (TOF-ICR) detection technique. Given the limited performance of the TOF-ICR detection when trying to investigate heavy/superheavy species with small production cross sections ({sigma} <1 {mu}b), a new detection system is found to be necessary. Thus, the second part of this thesis deals with the commissioning of a cryogenic double-Penning trap system for the application of a highly-sensitive, narrow-band Fourier-transform ion-cyclotron-resonance (FT-ICR) detection technique. With the non-destructive FT-ICR detection method a single singly-charged trapped ion will provide the required information to determine its mass. First off-line tests of a new detector system based on a channeltron with an attached conversion dynode, of a cryogenic pumping barrier, to guarantee ultra-high vacuum conditions during mass determination, and of the detection electronics for the required single-ion sensitivity are reported. (orig.)

  20. Fragmentation analysis of water-soluble atmospheric organic matter using ultrahigh-resolution FT-ICR mass spectrometry.

    Science.gov (United States)

    Leclair, Jeffrey P; Collett, Jeffrey L; Mazzoleni, Lynn R

    2012-04-17

    Isolated water-soluble atmospheric organic matter (AOM) analytes extracted from radiation fogwater samples were analyzed using collision induced dissociation with ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Tandem mass analysis was performed on several mass ranges between 100 and 400 Da to characterize the functional groups of AOM species. Compounds containing nitrogen and/or sulfur were targeted because of the high number of oxygen atoms contained in their molecular formulas. Due to the large number of isobaric ions in the precursor isolation ranges, large numbers of product ions resulted from collision induced dissociation. Common neutral losses were assigned by matching the molecular formulas of the expected product ions with the detected product ions within the appropriate mass spectra. Since polar functional groups are expected to affect the hygroscopic properties of aerosols, the losses of H(2)O, CO(2), CH(3)OH, HNO(3), CH(3)NO(3), SO(3), SO(4) and combinations of these were specifically targeted. Among the 421 compounds studied, the most frequently observed neutral losses were CO(2) (54%), H(2)O (43%) and CH(3)OH (40%). HNO(3) losses were observed for 63% of the studied nitrogen containing compounds and 33% of the studied compounds containing both nitrogen and sulfur. SO(3) losses were observed for 85% of the studied sulfur containing compounds and 42% of studied compounds containing both nitrogen and sulfur. A number of molecular formulas matching those of monoterpene ozonolysis SOA were observed; they include organonitrates, organosulfates, and nitroxy-organosulfates. Overall, the results of fragmentation analysis of 400+ individual molecular precursors elucidate the complexity and multifunctional nature of the isolated water-soluble AOM.

  1. High mass accuracy and high mass resolving power FT-ICR secondary ion mass spectrometry for biological tissue imaging

    NARCIS (Netherlands)

    Smith, D.F.; Kiss, A.; Leach, F.E.; Robinson, E.W.; Paša-Tolić, L.; Heeren, R.M.A.

    2013-01-01

    Biological tissue imaging by secondary ion mass spectrometry has seen rapid development with the commercial availability of polyatomic primary ion sources. Endogenous lipids and other small bio-molecules can now be routinely mapped on the sub-micrometer scale. Such experiments are typically

  2. Chemical characterization of synthetic cannabinoids by electrospray ionization FT-ICR mass spectrometry.

    Science.gov (United States)

    Kill, Jade B; Oliveira, Izabela F; Tose, Lilian V; Costa, Helber B; Kuster, Ricardo M; Machado, Leandro F; Correia, Radigya M; Rodrigues, Rayza R T; Vasconcellos, Géssica A; Vaz, Boniek G; Romão, Wanderson

    2016-09-01

    The synthetic cannabinoids (SCs) represent the most recent advent of the new psychotropic substances (NPS) and has become popularly known to mitigate the effects of the Δ(9)-THC. The SCs are dissolved in organic solvents and sprayed in a dry herbal blend. However, little information is reported on active ingredients of SCs as well as the excipients or diluents added to the herbal blend. In this work, the direct infusion electrospray ionization Fourier transform ion cyclotron mass spectrometry technique (ESI-FT-ICR MS) was applied to explore the chemical composition of nine samples of herbal extract blends, where a total of 11 SCs (UR-144, JWH-073, XLR-11, JWH-250, JWH-122, AM-2201, AKB48, JWH-210, JWH-081, MAM-2201 and 5F-AKB48) were identified in the positive ionization mode, ESI(+), and other 44 chemical species (saturated and unsaturated fatty acids, sugars, flavonoids, etc.) were detected in the negative ionization mode, ESI(-). Additionally, CID experiments were performed, and fragmentation pathways were proposed to identify the connectivity of SCs. Thus, the direct infusion ESI-FT-ICR MS technique is a powerful tool in forensic chemistry that enables the rapid and unequivocal way for the determination of molecular formula, the degree of unsaturation (DBE-double bond equivalent) and exact mass (<1ppm) of a total of 55 chemical species without the prior separation step. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  3. Organic environments on Saturn's moon, Titan: simulating chemical reactions and analyzing products by FT-ICR and ion-trap mass spectrometry.

    Science.gov (United States)

    Somogyi, Arpad; Oh, Chu-Ha; Smith, Mark A; Lunine, Jonathan I

    2005-06-01

    Laboratory simulations have been carried out to model chemical reactions that possibly take place in the stratosphere of Saturn's moon, Titan. The aerosol products of these reactions (tholin samples) have been systematically analyzed by mass spectrometry using electrospray ionization (ESI) and laser desorption (LD). A wide variety of ions with a general formula C(x)H(y)N(z) detected by ultrahigh resolution and accurate mass measurements in a Fourier transform/ion cyclotron resonance (FT-ICR) cell reflect the complexity of these polymeric products, both in chemical compositions and isomeric distributions. As a common feature, however, tandem mass spectral (MS/MS) data and H/D exchange products in the solution phase support the presence of amino and nitrile functionalities in these (highly unsaturated) "tholin" compounds. The present work demonstrates that ESI-MS coupled with FT-ICR is a suitable and "intact" method to analyze tholin components formed under anaerobic conditions; only species with C(x)H(y)N(z) are detected for freshly prepared and harvested samples. However, when intentionally exposed to water, oxygen-containing compounds are unambiguously detected.

  4. Hydrothermal liquefaction oil and hydrotreated product from pine feedstock characterized by heteronuclear two-dimensional NMR spectroscopy and FT-ICR mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Sudasinghe, Nilusha; Cort, John R.; Hallen, Richard T.; Olarte, Mariefel V.; Schmidt, Andrew J.; Schaub, Tanner

    2014-12-01

    Hydrothermal liquefaction (HTL) crude oil and hydrotreated product from pine tree farm waste (forest product residual, FPR) have been analyzed by direct infusion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) in both positive- and negative-ionization modes and high-resolution twodimensional heteronuclear 1H-13C NMR spectroscopy. FT-ICR MS resolves thousands of compounds in complex oils and provides unparalleled compositional details for individual molecules for identification of compound class (heteroatom content), type (number of rings plus double bonds to carbon or double bond equivalents (DBE) and carbon number (degree of alkylation). Heteronuclear 1H-13C NMR spectroscopy provides one-bond and multiple-bond correlations between pairs of 1H and 13C chemical shifts that are characteristic of different organic functional groups. Taken together this information provides a picture of the chemical composition of these oils. Pyrolysis crude oil product from pine wood was characterized for comparison. Generally, pyrolysis oil is comprised of a more diverse distribution of heteroatom classes with higher oxygen number relative to HTL oil as shown by both positive- and negative-ion ESI FT-ICR MS. A total of 300 N1, 594 O1 and 267 O2 compounds were observed as products of hydrotreatment. The relative abundance of N1O1, N1O2, N1O3, N2, N2O1, N2O2 and O3 compounds are reduced to different degrees after hydrotreatment and other higher heteroatom containing species (O4-O10, N1O4, N1O5 and N2O3) are completely removed by hydrotreatment.

  5. Exploring Biosignatures Associated with Thenardite by Geomatrix-Assisted Laser Desorption/Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (GALDI-FTICR-MS)

    Energy Technology Data Exchange (ETDEWEB)

    C. Doc Richardson; Nancy W. Hinman; Timothy R. McJunkin; J. Michelle Kotler; Jill R. Scott

    2008-10-01

    Geomatrix-assisted laser desorption/ionization (GALDI) in conjunction with a Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS) has been employed to determine how effectively bio/organic molecules associated with the mineral thenardite (Na2SO4) can be detected. GALDI is based on the ability of the mineral host to assist desorption and ionization of bio/organic molecules without additional sample preparation. When glycine was mixed with thenardite, glycine was deprotonated to produce C2H4NO-2 at m/z 74.025. The combination of stearic acid with thenardite produced a complex cluster ion at m/z 390.258 in the negative mode, which was assigned a composition ofC18H39O7Na-. Anatural sample of thenardite from Searles Lake in California also produced a peak at m/z 390.260. The bio/organic signatures in both the laboratory-based and natural samples were heterogeneously dispersed as revealed by chemical imaging. The detection limits for the stearic acid and thenardite combination were estimated to be 3 parts per trillion or~7 zeptomoles (10-21) per laser spot. Attempts to improve the signal-to-noise ratio by co-adding FTICR-MS data predetermined to contain the biosignatures of interest revealed problems due to a lack of phase coherence between data sets.

  6. Rapid Screening for Potential Epitopes Reactive with a Polycolonal Antibody by Solution-Phase H/D Exchange Monitored by FT-ICR Mass Spectrometry

    Science.gov (United States)

    Zhang, Qian; Noble, Kyle A.; Mao, Yuan; Young, Nicolas L.; Sathe, Shridhar K.; Roux, Kenneth H.; Marshall, Alan G.

    2013-07-01

    The potential epitopes of a recombinant food allergen protein, cashew Ana o 2, reactive to polyclonal antibodies, were mapped by solution-phase amide backbone H/D exchange (HDX) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Ana o 2 polyclonal antibodies were purified in the serum from a goat immunized with cashew nut extract. Antibodies were incubated with recombinant Ana o 2 (rAna o 2) to form antigen:polyclonal antibody (Ag:pAb) complexes. Complexed and uncomplexed (free) rAna o 2 were then subjected to HDX-MS analysis. Four regions protected from H/D exchange upon pAb binding are identified as potential epitopes and mapped onto a homologous model.

  7. Utilizing a Robotic Sprayer for High Lateral and Mass Resolution MALDI FT-ICR MSI of Microbial Cultures

    Energy Technology Data Exchange (ETDEWEB)

    Anderton, Christopher R.; Chu, Rosalie K.; Tolic, Nikola; Creissen, Alain V.; Pasa-Tolic, Ljiljana

    2016-01-07

    The ability to visualize biochemical interactions between microbial communities using MALDI MSI has provided tremendous insights into a variety of biological fields. Matrix application using a sieve proved to be incredibly useful, but it had many limitations that include uneven matrix coverage and limitation in the types of matrices one could employ in their studies. Recently, there has been a concerted effort to improve matrix application for studying agar plated microbial cultures, many of which utilized automated matrix sprayers. Here, we describe the usefulness of using a robotic sprayer for matrix application. The robotic sprayer has two-dimensional control over where matrix is applied and a heated capillary that allows for rapid drying of the applied matrix. This method provided a significant increase in MALDI sensitivity over the sieve method, as demonstrated by FT-ICR MS analysis, facilitating the ability to gain higher lateral resolution MS images of Bacillus Subtilis than previously reported. This method also allowed for the use of different matrices to be applied to the culture surfaces.

  8. High-field NMR spectroscopy and FTICR mass spectrometry: powerful discovery tools for the molecular level characterization of marine dissolved organic matter

    Directory of Open Access Journals (Sweden)

    N. Hertkorn

    2013-03-01

    exceptional resolution and depicted resolved molecular signatures in excess of a certain minimum abundance. Classical methyl groups terminating aliphatic chains represented ~15% of total methyl in all samples investigated. A noticeable fraction of methyl (~2% was bound to olefinic carbon. Methyl ethers were abundant in surface marine SPE-DOM, and the chemical diversity of carbohydrates was larger than that of freshwater and soil DOM. In all samples, we identified sp2-hybridized carbon chemical environments with discrimination of isolated and conjugated olefins and α,β-unsaturated double bonds. Olefinic proton and carbon atoms were more abundant than aromatic ones; olefinic unsaturation in marine SPE-DOM will be more directly traceable to ultimate biogenic precursors than aromatic unsaturation. The abundance of furan, pyrrol and thiophene derivatives was marginal, whereas benzene derivatives, phenols and six-membered nitrogen heterocycles were prominent; a yet unassigned set of six-membered N-heterocycles with likely more than one single nitrogen occurred in all samples. Various key polycyclic aromatic hydrocarbon substructures suggested the presence of thermogenic organic matter at all water depths. Progressive NMR cross-peak attenuation from surface to deep marine SPE-DOM was particularly strong in COSY NMR spectra and indicated a continual disappearance of biosignatures as well as entropy gain from an ever increased molecular diversity. Nevertheless, a specific near-seafloor SPE-DOM signature of unsaturated molecules recognized in both NMR and Fourier transform ion cyclotron mass spectrometry (FTICR/MS possibly originated from sediment leaching. The conformity of key NMR and FTICR/MS signatures suggested the presence of a large set of identical molecules throughout the entire ocean column even though the investigated water masses belonged to different oceanic regimes and currents. FTICR/MS showed abundant CHO, CHNO, CHOS and CHNOS molecular series with slightly increasing

  9. Petroleomics by electrospray ionization FT-ICR mass spectrometry coupled to partial least squares with variable selection methods: prediction of the total acid number of crude oils.

    Science.gov (United States)

    Terra, Luciana A; Filgueiras, Paulo R; Tose, Lílian V; Romão, Wanderson; de Souza, Douglas D; de Castro, Eustáquio V R; de Oliveira, Mirela S L; Dias, Júlio C M; Poppi, Ronei J

    2014-10-07

    Negative-ion mode electrospray ionization, ESI(-), with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) was coupled to a Partial Least Squares (PLS) regression and variable selection methods to estimate the total acid number (TAN) of Brazilian crude oil samples. Generally, ESI(-)-FT-ICR mass spectra present a power of resolution of ca. 500,000 and a mass accuracy less than 1 ppm, producing a data matrix containing over 5700 variables per sample. These variables correspond to heteroatom-containing species detected as deprotonated molecules, [M - H](-) ions, which are identified primarily as naphthenic acids, phenols and carbazole analog species. The TAN values for all samples ranged from 0.06 to 3.61 mg of KOH g(-1). To facilitate the spectral interpretation, three methods of variable selection were studied: variable importance in the projection (VIP), interval partial least squares (iPLS) and elimination of uninformative variables (UVE). The UVE method seems to be more appropriate for selecting important variables, reducing the dimension of the variables to 183 and producing a root mean square error of prediction of 0.32 mg of KOH g(-1). By reducing the size of the data, it was possible to relate the selected variables with their corresponding molecular formulas, thus identifying the main chemical species responsible for the TAN values.

  10. High field NMR spectroscopy and FTICR mass spectrometry: powerful discovery tools for the molecular level characterization of marine dissolved organic matter from the South Atlantic Ocean

    Science.gov (United States)

    Hertkorn, N.; Harir, M.; Koch, B. P.; Michalke, B.; Grill, P.; Schmitt-Kopplin, P.

    2012-01-01

    methyl (CH3) in marine DOM were nicely discriminated in DEPT HSQC NMR spectra. Classical methyl groups terminating aliphatic chains represented only ~15% of total methyl in all marine DOM investigated. Chemical shift anisotropy from carbonyl derivatives (i.e. most likely carboxylic acids) displaced aliphatic methyl 1H NMR resonances up to δH ~1.6 ppm, indicative of alicyclic geometry which furnishes more numerous short range connectivities for any given atom pairs. A noticeable fraction of methyl (~2%) was bound to olefinic carbon. The comparatively large abundance of methyl ethers in surface marine DOM contrasted with DOM of freshwater and soil origin. The chemical diversity of carbohydrates as indicated by H2CO-groups (δC ~ 62 ± 2 ppm) and anomerics (δC ~ 102 ± 7 ppm) exceeded that of freshwater and soil DOM considerably. HSQC NMR spectra were best suited to identify chemical environments of methin carbon (CH) and enabled discrimination of olefinic and aromatic cross peaks (δC > 110 ppm) and those of doubly oxygenated carbon (δC 8 ppm). Specifically, a rather confined HSQC cross peak at δH/δC = 8.2/164 ppm indicated a limited set of nitrogen heterocycles with several nitrogen atoms in analogy to RNA derivatives present in all four marine DOM. Appreciable amounts of extended HSQC and TOCSY cross peaks derived from various key polycyclic aromatic hydrocarbon substructures suggested the presence of previously proposed but NMR invisible thermogenic organic matter (TMOC) in marine DOM at all water depths. Eventually, olefinic unsaturation in marine DOM will be more directly traceable to ultimate biogenic precursors than aromatic unsaturation of which a substantial fraction originates from an aged material which from the beginning was subjected to complex and less specific biogeochemical reactions like thermal decomposition. The variance in molecular mass as indicated from Fourier transform ion cyclotron resonance (FTICR) mass spectra was limited and could not

  11. Ions generated from uranyl nitrate solutions by electrospray ionization (ESI) and detected with Fourier transform ion-cyclotron resonance (FT-ICR) mass spectrometry.

    Science.gov (United States)

    Pasilis, Sofie; Somogyi, Arpád; Herrmann, Kristin; Pemberton, Jeanne E

    2006-02-01

    Electrospray ionization (ESI) of uranyl nitrate solutions generates a wide variety of positively and negatively charged ions, including complex adducts of uranyl ions with methoxy, hydroxy, and nitrate ligands. In the positive ion mode, ions detected by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry are sensitive to instrumental tuning parameters such as quadrupole operating frequency and trapping time. Positive ions correspond to oligomeric uranyl nitrate species that can be characterized as having a general formula of [(UO(2))(n)(A)(m)(CH(3)OH)(s)](+) or [(UO(2))(n)(O)(A)(m)(CH(3)OH)(s)](+) with n = 1-4, m = 1-7, s = 0 or 1, and A = OH, NO(3), CH(3)O or a combination of these, although the formation of NO(3)-containing species is preferred. In the negative ion mode, complexes of the form [(UO(2))(NO(3))(m)](-) (m = 1-3) are detected, although the formation of the oxo-containing ions [(UO(2))(O)(n)(NO(3))(m)](-) (n = 1-2, m = 1-2) and the hydroxy-containing ions [(UO(2))(OH)(n)(NO(3))(m)](-) (n = 1-2, m = 0-1) are also observed. The extent of coordinative unsaturation of both positive and negative ions can be determined by ligand association/exchange and H/D exchange experiments using D(2)O and CD(3)OD as neutral reaction partners in the gas-phase. Positive ions are of varying stability and reactivity and may fragment extensively upon collision with D(2)O, CD(3)OD and N(2) in sustained off-resonance irradiation/collision-induced dissociation (SORI-CID) experiments. Electron-transfer reactions, presumably occurring during electrospray ionization but also in SORI-CID, can result in reduction of U(VI) to U(V) and perhaps even U(IV).

  12. Molecular Characterization of Organosulfates in Urban Aerosols during the Spring Festival by FT-ICR Mass Spectrometry

    Science.gov (United States)

    Xie, Q.; Fu, P.

    2017-12-01

    Aerosol particles collected at daytime and nighttime in Beijing during the spring festival, including the episodes of various gradient level pollution and short-term pollution raised by fireworks, were analyzed using 15T Fourier transform ion cyclotron resonance mass spectrometry (FT-ICRMS). Organosulfates (OSs), tracers for secondary organic aerosol formation, were identified through accurate mass measurements. Both the total number and the arbitrary abundance of OSs were consistent with the total OC concentrations of the aerosol samples. Nitrooxy-organosulfates were more abundant in the nighttime than those in the daytime due to high NOX concentrations at night. Although all subgroups OSs increased with the deterioration of air quality, especially for the relative abundance of aromatic OSs with high double bond equivalents, the percentage contributions of aliphatic OSs with low degree of unsaturation decreased. It was worth to note that aliphatic OSs with a wide range in carbon-chain length of C6-40 were identified in this study. The candidates for their potential precursors were alkanes and fatty acids. Moreover, a large number of aromatic OSs, about two thirds of OSs, were detected. The rapid formation of these compounds in New Year's Eve with plentiful aromatics from firework burning suggests that they may be derived from PAHs. The high carbon and oxygen contents of OSs may indicate the presence of dimmers, even polymers. Our results support the important contribution of anthropogenic precursors to OSs in ambient aerosols on the basis of aromatic and aliphatic OSs, which may have a significant impact on the hygroscopic properties of ambient aerosol particles.

  13. Developments in FT-ICR MS instrumentation, ionization techniques, and data interpretation methods for petroleomics.

    Science.gov (United States)

    Cho, Yunju; Ahmed, Arif; Islam, Annana; Kim, Sunghwan

    2015-01-01

    Because of the increasing importance of heavy and unconventional crude oil as an energy source, there is a growing need for petroleomics: the pursuit of more complete and detailed knowledge of the chemical compositions of crude oil. Crude oil has an extremely complex nature; hence, techniques with ultra-high resolving capabilities, such as Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), are necessary. FT-ICR MS has been successfully applied to the study of heavy and unconventional crude oils such as bitumen and shale oil. However, the analysis of crude oil with FT-ICR MS is not trivial, and it has pushed analysis to the limits of instrumental and methodological capabilities. For example, high-resolution mass spectra of crude oils may contain over 100,000 peaks that require interpretation. To visualize large data sets more effectively, data processing methods such as Kendrick mass defect analysis and statistical analyses have been developed. The successful application of FT-ICR MS to the study of crude oil has been critically dependent on key developments in FT-ICR MS instrumentation and data processing methods. This review offers an introduction to the basic principles, FT-ICR MS instrumentation development, ionization techniques, and data interpretation methods for petroleomics and is intended for readers having no prior experience in this field of study. © 2014 Wiley Periodicals, Inc.

  14. Applications of Fourier Transform Ion Cyclotron Resonance (FT-ICR) and Orbitrap Based High Resolution Mass Spectrometry in Metabolomics and Lipidomics

    Science.gov (United States)

    Ghaste, Manoj; Mistrik, Robert; Shulaev, Vladimir

    2016-01-01

    Metabolomics, along with other “omics” approaches, is rapidly becoming one of the major approaches aimed at understanding the organization and dynamics of metabolic networks. Mass spectrometry is often a technique of choice for metabolomics studies due to its high sensitivity, reproducibility and wide dynamic range. High resolution mass spectrometry (HRMS) is a widely practiced technique in analytical and bioanalytical sciences. It offers exceptionally high resolution and the highest degree of structural confirmation. Many metabolomics studies have been conducted using HRMS over the past decade. In this review, we will explore the latest developments in Fourier transform mass spectrometry (FTMS) and Orbitrap based metabolomics technology, its advantages and drawbacks for using in metabolomics and lipidomics studies, and development of novel approaches for processing HRMS data. PMID:27231903

  15. Characterization of non-polar aromatic hydrocarbons in crude oil using atmospheric pressure laser ionization and Fourier transform ion cyclotron resonance mass spectrometry (APLI FT-ICR MS).

    Science.gov (United States)

    Schrader, Wolfgang; Panda, Saroj K; Brockmann, Klaus J; Benter, Thorsten

    2008-07-01

    We report on the successful application of the recently introduced atmospheric pressure laser ionization (APLI) method as a novel tool for the analysis of crude oil and its components. Using Fourier transform ion cyclotron resonance mass spectrometry, unambiguous determination of key compounds in this complex matrix with unprecedented sensitivity is presented.

  16. Successive ligand substitutions in the Fe(CO)n+/H2O systems (n = 1-5) observed in a triple cell FT-ICR mass spectrometer

    International Nuclear Information System (INIS)

    Le Caer, S.; Heninger, M.; Mestdagh, H.

    2002-01-01

    The reactivity of the Fe(CO) n + ions on H 2 O to obtain accurate information on the different ligand substitutions was studied. The energy dependence of rate constants was also investigated; various Fe(CO) n + /L(methanol, dimethylene) systems studied were found to be strongly dependent of the reacting ions. The experimental set-up consisted in three ICR cells which are differentially pumped. The first is used as an ion source: the ions are generated by electron impact ionization upon Fe(CO) 5 , and are mass selected; then they are transferred into the second cell, in which they can relaxed either radiatively or collisionally with Ar atoms, before going to the third cell where they react with water molecules during various times at constant pressure. Then they are drifted back to the second cell in order to be mass detected. In all the Fe(CO) n + ions / H 2 O systems (n=1-4), ligand substitutions were the only reactions observed. No reaction was observed in the Fe(CO) 5 + ions / H 2 O system. The different reactions along with the rate constants as well as the experimental dependence of the rate constant k as a function of the number of collisions with Ar atoms in the third cell are presented. (nevyjel)

  17. An Automated High Performance Capillary Liquid Chromatography Fourier Transform Ion Cyclotron Resonance Mass Spectrometer for High-Throughput Proteomics

    International Nuclear Information System (INIS)

    Belov, Mikhail E.; Anderson, Gordon A.; Wingerd, Mark A.; Udseth, Harold R.; Tang, Keqi; Prior, David C.; Swanson, Kenneth R.; Buschbach, Michael A.; Strittmatter, Eric F.; Moore, Ronald J.; Smith, Richard D.

    2004-01-01

    We report on a fully automated 9.4 tesla Fourier transform ion resonance cyclotron (FTICR) mass spectrometer coupled to reverse-phase chromatography for high-throughput proteomic studies. Modifications made to the front-end of a commercial FTICR instrument--a dual-ESI-emitter ion source; dual-channel electrodynamic ion funnel; and collisional-cooling, selection and accumulation quadrupoles--significantly improved the sensitivity, dynamic range and mass measurement accuracy of the mass spectrometer. A high-pressure capillary liquid chromatography (LC) system was incorporated with an autosampler that enabled 24 h/day operation. A novel method for accumulating ions in the ICR cell was also developed. Unattended operation of the instrument revealed the exceptional reproducibility (1-5% deviation in elution times for peptides from a bacterial proteome), repeatability (10-20% deviation in detected abundances for peptides from the same aliquot analyzed a few weeks apart) and robustness (high-throughput operation for 5 months without downtime) of the LC/FTICR system. When combined with modulated-ion-energy gated trapping, the internal calibration of FTICR mass spectra decreased dispersion of mass measurement errors for peptide identifications in conjunction with high resolution capillary LC separations to < 5 ppm over a dynamic range for each spectrum of 10 3

  18. Gold chloride clusters with Au(III) and Au(I) probed by FT-ICR mass spectrometry and MP2 theory.

    Science.gov (United States)

    Lemke, Kono H

    2014-05-07

    Microsolvated clusters of gold chloride are probed by electrospray ionization mass spectrometry (ESI-MS) and scalar relativistic electronic structure calculations. Electrospray ionization of aqueous AuCl3 leads to mononuclear clusters of types [AuCl2](+)(H2O)n (n = 0-4), [AuOHCl](+)(H2O)n (n = 0-1) and [AuCl2](+)(HCl)2(H2O)n (n = 0-4). In addition, strong ion signals due to dinuclear [Au2Cl5-xOHx](+)(H2O)n (x = 0-1) are present in ESI mass spectra of aqueous AuCl3, with the abundance of individual dinuclear species controlled by the concentration-dependent variation of the precursor complexes [AuCl2-xOHx](+)(H2O)n and AuCl3. Equilibrium structures, energies and thermodynamic properties of mono- and dinuclear gold clusters have been predicted using MP2 and CCSD(T) theory, and these data have been applied to examine the influence of microsolvation on cluster stability. Specifically, results from CCSD(T) calculations indicate that non-covalently bound ion-neutral complexes Au(+)(Cl2)(H2O)n, with formal Au(I), are the dominant forms of mononuclear gold with n = 0-2, while higher hydrates (n > 2) are covalently bound [AuCl2](+)(H2O)n complexes in which gold exists as Au(III). MP2 calculations show that the lowest energy structure of dinuclear gold is an ion-molecule cluster [Au2Cl(Cl2)2](+) consisting of a single-bridged digold-chloronium ion bound end-on to two dichlorine ligands, with two higher energy isomers, single-bridged [Au2Cl3(Cl2)](+) and double-bridged [Au2Cl5](+) clusters. Finally, AuAu interactions in the singly-bridged clusters [Au2Cl(Cl2)2](+)(H2O)n and [Au2Cl3(Cl2)](+)(H2O)n are examined employing a wide range of computational tools, including natural bond order (NBO) analysis and localized orbital locator (LOL) profiles.

  19. Manual of Tesla Experiments; Handbuch Tesla Experimente

    Energy Technology Data Exchange (ETDEWEB)

    Wahl, Guenter

    2009-07-01

    The first part, ''Making Lightning and Thunder'', describes a number of Tesla generators that can generate, e.g., coloured light arcs, ball lightning and swords of lightning. The second part, ''New Experiments with EMP, Tesla Waves and Microwaves'', presents a solid state Tesla generator for generating electrodynamic vortices and proposes circuiting alternatives to generate electromagnetic pulses (EMP). Further, mysterious Teslar wave, microwave and scalar wave generators are presented, as well as exotic Star Wars experiments like mass accelerators and plasma guns. The third section describes, among others, a tube-driven Tesla generator with 50 cm streamers. The reader will also find a catalogue of Messrs. Information Unlimited, USA, who are providers of many of the kits, circuiting diagrams and apparatuses presented here. (orig.) [German] Der erste Teil mit dem Titel ''Blitz und Donner selbst erzeugt'' beschreibt eine Reihe von Teslageneratoren, mit denen zum Beispiel bunte Lichtbogen, Kugelblitze und Blitzschwerter erzeugt werden koennen. Im zweiten Teil ''Neue Experimente mit EMPs, Tesla- and Mikrowellen'' findet der Leser einen Solid-State-Teslagenerator zur Erzeugung elektrodynamischer Wirbel sowie Schaltungsvorschlaege zum Thema ''Elektromagnetischer Impuls'' (EMP). Des Weiteren werden geheimnisumwitterte Tesla-, Mikro- und Skalarwellengeneratoren vorgestellt. Exotische Star-Wars-Experimente wie Massenbeschleuniger und Plasmakanonen fehlen ebenfalls nicht. Im dritten Teil wird unter anderem ein roehrenbetriebener Teslagenerator mit Streamern von 50 cm Laenge beschrieben. Ausserdem findet der Leser hier einen Katalog der US-Firma Information Unlimited, bei der viele im Buch besprochenen Bausaetze, Schaltplaene und Fertiggeraete bezogen werden koennen. (orig.)

  20. Combined 3 Tesla MRI Biomarkers Improve the Differentiation between Benign vs Malignant Single Ring Enhancing Brain Masses.

    Directory of Open Access Journals (Sweden)

    Simone Salice

    Full Text Available To evaluate whether the combination of imaging biomarkers obtained by means of different 3 Tesla (3T Magnetic Resonance Imaging (MRI advanced techniques can improve the diagnostic accuracy in the differentiation between benign and malignant single ring-enhancing brain masses.14 patients presenting at conventional 3T MRI single brain mass with similar appearance as regard ring enhancement, presence of peri-lesional edema and absence of hemorrhage signs were included in the study. All lesions were histologically proven: 5 pyogenic abscesses, 6 glioblastomas, and 3 metastases. MRI was performed at 3 Tesla and included Diffusion Weighted Imaging (DWI, Dynamic Susceptibility Contrast -Perfusion Weighted Imaging (DSC-PWI, Magnetic Resonance Spectroscopy (MRS, and Diffusion Tensor Imaging (DTI. Imaging biomarkers derived by those advanced techniques [Cerebral Blood Flow (CBF, relative Cerebral Blood Volume (rCBV, relative Main Transit Time (rMTT, Choline (Cho, Creatine (Cr, Succinate, N-Acetyl Aspartate (NAA, Lactate (Lac, Lipids, relative Apparent Diffusion Coefficient (rADC, and Fractional Anisotropy (FA] were detected by two experienced neuroradiologists in joint session in 4 areas: Internal Cavity (IC, Ring Enhancement (RE, Peri-Lesional edema (PL, and Contralateral Normal Appearing White Matter (CNAWM. Significant differences between benign (n = 5 and malignant (n = 9 ring enhancing lesions were tested with Mann-Withney U test. The diagnostic accuracy of MRI biomarkers taken alone and MRI biomarkers ratios were tested with Receiver Operating Characteristic (ROC analysis with an Area Under the Curve (AUC ≥ 0.9 indicating a very good diagnostic accuracy of the variable.Five MRI biomarker ratios achieved excellent accuracy: IC-rADC/PL-NAA (AUC = 1, IC-rADC/IC-FA (AUC = 0.978, RE-rCBV/RE-FA (AUC = 0.933, IC-rADC/RE-FA (AUC = 0.911, and IC-rADC/PL-FA (AUC = 0.911. Only IC-rADC achieved a very good diagnostic accuracy (AUC = 0.909 among MRI biomarkers

  1. Improved Diagnostic Accuracy in Characterization of Adnexal Masses by Detection of Choline Peak Using 1H MR Spectroscopy in Comparison to Internal Reference at 3 Tesla.

    Science.gov (United States)

    Malek, Mahrooz; Pourashraf, Maryam; Gilani, Mitra Modares; Gity, Masoumeh

    2015-01-01

    The aim of this study was to assess the role of the presence of a choline peak in 3 Tesla 1H magnetic resonance spectroscopy (MRS) for differentiating benign from malignant adnexal masses. A total of 46 adnexal masses (23 malignant and 23 benign) underwent 1H MRS study prior to surgery to assess the presence of choline peak. A choline peak was detected in 16 malignant masses (69.5%) and was absent in the other 7 (30.5%). A choline peak was only detected in 6 (26%) of the benign adnexal masses. The presence of an MRS choline peak had a sensitivity of 69.5%, a specificity of 74%, a positive predictive value (PPV) of 72.7%, and a negative predictive value (NPV) of 71% for diagnosing malignant adnexal masses. A significant difference between the frequency of mean choline peaks in benign and malignant adnexal masses was observed (P valuepeak is seen in malignant adnexal masses more frequently than the benign masses, and may be helpful for diagnosing malignant adnexal masses.

  2. 2D FT-ICR MS of Calmodulin: A Top-Down and Bottom-Up Approach.

    Science.gov (United States)

    Floris, Federico; van Agthoven, Maria; Chiron, Lionel; Soulby, Andrew J; Wootton, Christopher A; Lam, Yuko P Y; Barrow, Mark P; Delsuc, Marc-André; O'Connor, Peter B

    2016-09-01

    Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry (2D FT-ICR MS) allows data-independent fragmentation of all ions in a sample and correlation of fragment ions to their precursors through the modulation of precursor ion cyclotron radii prior to fragmentation. Previous results show that implementation of 2D FT-ICR MS with infrared multi-photon dissociation (IRMPD) and electron capture dissociation (ECD) has turned this method into a useful analytical tool. In this work, IRMPD tandem mass spectrometry of calmodulin (CaM) has been performed both in one-dimensional and two-dimensional FT-ICR MS using a top-down and bottom-up approach. 2D IRMPD FT-ICR MS is used to achieve extensive inter-residue bond cleavage and assignment for CaM, using its unique features for fragment identification in a less time- and sample-consuming experiment than doing the same thing using sequential MS/MS experiments. Graphical Abstract ᅟ.

  3. Distributed computing strategies for processing of FT-ICR MS imaging datasets for continuous mode data visualization

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Donald F.; Schulz, Carl; Konijnenburg, Marco; Kilic, Mehmet; Heeren, Ronald M.

    2015-03-01

    High-resolution Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging enables the spatial mapping and identification of biomolecules from complex surfaces. The need for long time-domain transients, and thus large raw file sizes, results in a large amount of raw data (“big data”) that must be processed efficiently and rapidly. This can be compounded by largearea imaging and/or high spatial resolution imaging. For FT-ICR, data processing and data reduction must not compromise the high mass resolution afforded by the mass spectrometer. The continuous mode “Mosaic Datacube” approach allows high mass resolution visualization (0.001 Da) of mass spectrometry imaging data, but requires additional processing as compared to featurebased processing. We describe the use of distributed computing for processing of FT-ICR MS imaging datasets with generation of continuous mode Mosaic Datacubes for high mass resolution visualization. An eight-fold improvement in processing time is demonstrated using a Dutch nationally available cloud service.

  4. RAPID AND AUTOMATED PROCESSING OF MALDI-FTICR/MS DATA FOR N-METABOLIC LABELING IN A SHOTGUN PROTEOMICS ANALYSIS.

    Science.gov (United States)

    Jing, Li; Amster, I Jonathan

    2009-10-15

    Offline high performance liquid chromatography combined with matrix assisted laser desorption and Fourier transform ion cyclotron resonance mass spectrometry (HPLC-MALDI-FTICR/MS) provides the means to rapidly analyze complex mixtures of peptides, such as those produced by proteolytic digestion of a proteome. This method is particularly useful for making quantitative measurements of changes in protein expression by using (15)N-metabolic labeling. Proteolytic digestion of combined labeled and unlabeled proteomes produces complex mixtures that with many mass overlaps when analyzed by HPLC-MALDI-FTICR/MS. A significant challenge to data analysis is the matching of pairs of peaks which represent an unlabeled peptide and its labeled counterpart. We have developed an algorithm and incorporated it into a compute program which significantly accelerates the interpretation of (15)N metabolic labeling data by automating the process of identifying unlabeled/labeled peak pairs. The algorithm takes advantage of the high resolution and mass accuracy of FTICR mass spectrometry. The algorithm is shown to be able to successfully identify the (15)N/(14)N peptide pairs and calculate peptide relative abundance ratios in highly complex mixtures from the proteolytic digest of a whole organism protein extract.

  5. New Tesla-Experiment; Neue Tesla-Experimente

    Energy Technology Data Exchange (ETDEWEB)

    Wahl, Guenter; Harthun, Norbert

    2010-07-01

    Mysterious Teslar wave, microwave and scalar wave generators are presented, as well as exotic Star Wars experiments like mass accelerators and plasma guns. The third section describes, among others, a tube-driven Tesla generator with 50 cm streamers. The reader will also find a catalogue of Messrs. Information Unlimited, USA, who are providers of many of the kits, circuiting diagrams and apparatuses presented here. Main topic in this issue is wireless energy transfer and telecommunication engineering.(orig./GL)

  6. Nikola Tesla: een biografie

    NARCIS (Netherlands)

    ir.ing. Ruud Thelosen

    2015-01-01

    De Technische uitvinder Tesla heeft 700 patenten op zijn naam staan als hij overlijdt. Zijn uitvindingen hebben de wereld in de 20e eeuw volledig veranderd. Zijn wisselstroom generator hebben heel de VS van elektriciteit voorzien. Radioverkeer , remote control werd mogelijk dankzij Tesla. Volgens

  7. The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging.

    Science.gov (United States)

    Göya, Cemil; Hamidi, Cihad; Bozkurt, Yaşar; Yavuz, Alpaslan; Kuday, Suzan; Gümüş, Hatice; Türkçü, Gül; Hattapoğlu, Salih; Bilici, Aslan

    2015-07-01

    Diffusion-weighted magnetic resonance imaging (DWI) is a widely-accepted diagnostic modality whose efficacy has been investigated by numerous past studies in the differentiation of malignant lesions from benign entities. The aim of this study was to evaluate the efficiency of diffusion-weighted magnetic resonance imaging in the characterization of renal lesions. Diagnostic accuracy study. A total of 137 patients with renal lesions were included in this study. The median apparent diffusion coefficient (ADC) values as well as the b 800 and b 1600 signal intensities of normal kidneys, solid components of mixed renal masses, and total cystic lesions were evaluated. There were significant differences between the ADC values of lesions and normal renal parenchyma, and between the ADC values of benign and malignant renal lesions on DWIs at b values of 800 and 1600 s/mm(2) (pbenign and malignant renal lesions. A cutoff value of 1.623 × 10(-3) mm(2)/s for the ADC with a b value of 1600 s/mm(2) provided 79% sensitivity and 96% specificity (pbenign and malignant renal lesions. Accurate assessment of renal masses is important for determining the necessity for surgical intervention. DWI provides additional value by differentiating benign from malignant renal tumors and can be added to routine kidney MRI protocols.

  8. The TESLA RF System

    International Nuclear Information System (INIS)

    Choroba, S.

    2003-01-01

    The TESLA project proposed by the TESLA collaboration in 2001 is a 500 to 800GeV e+/e- linear collider with integrated free electron laser facility. The accelerator is based on superconducting cavity technology. Approximately 20000 superconducting cavities operated at 1.3GHz with a gradient of 23.4MV/m or 35MV/m will be required to achieve the energy of 500GeV or 800GeV respectively. For 500GeV ∼600 RF stations each generating 10MW of RF power at 1.3GHz at a pulse duration of 1.37ms and a repetition rate of 5 or 10Hz are required. The original TESLA design was modified in 2002 and now includes a dedicated 20GeV electron accelerator in a separate tunnel for free electron laser application. The TESLA XFEL will provide XFEL radiation of unprecedented peak brilliance and full transverse coherence in the wavelength range of 0.1 to 6.4nm at a pulse duration of 100fs. The technology of both accelerators, the TESLA linear collider and the XFEL, will be identical, however the number of superconducting cavities and RF stations for the XFEL will be reduced to 936 and 26 respectively. This paper describes the layout of the entire RF system of the TESLA linear collider and the TESLA XFEL and gives an overview of its various subsystems and components

  9. TESLA project goes public

    International Nuclear Information System (INIS)

    Flegel', I.

    2002-01-01

    The TESLA project connected with the creation of superconducting linear accelerator with colliding neutron and positron beams in the DESY Laboratory (Hamburg) is presented. Scientists of 36 countries make a contribution in the Feasibility study of new accelerator construction. Creation of new accelerator will open the way to the investigation into new elementary particles; TESLA is perfectly suitable for the production of Higgs particles. Exact measurements on the unit will allow to research into properties of supersymmetrical particles. The TESLA project involves the creation of X-ray free electron laser [ru

  10. Linear Colliders TESLA

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    The aim of the TESLA (TeV Superconducting Linear Accelerator) collaboration (at present 19 institutions from seven countries) is to establish the technology for a high energy electron-positron linear collider using superconducting radiofrequency cavities to accelerate its beams. Another basic goal is to demonstrate that such a collider can meet its performance goals in a cost effective manner. For this the TESLA collaboration is preparing a 500 MeV superconducting linear test accelerator at the DESY Laboratory in Hamburg. This TTF (TESLA Test Facility) consists of four cryomodules, each approximately 12 m long and containing eight 9-cell solid niobium cavities operating at a frequency of 1.3 GHz

  11. Changes in the expression of N- and O-glycopeptides in patients with colorectal cancer and hepatocellular carcinoma quantified by full-MS scan FT-ICR and multiple reaction monitoring

    Czech Academy of Sciences Publication Activity Database

    Darebná, P.; Novák, Petr; Kučera, R.; Topolčan, O.; Sanda, M.; Goldman, R.; Pompach, Petr

    2017-01-01

    Roč. 153, SI (2017), s. 44-52 ISSN 1874-3919 Grant - others:Ministerstvo pro místní rozvoj(CZ) CZ2.16./3.1.00/24023 Institutional support: RVO:61388971 Keywords : Mass spectrometry * Glycomics * FT-ICR Subject RIV: EE - Microbiology, Virology OBOR OECD: Microbiology Impact factor: 3.914, year: 2016

  12. Photon collider at TESLA

    International Nuclear Information System (INIS)

    Telnov, Valery

    2001-01-01

    High energy photon colliders (γγ, γe) based on backward Compton scattering of laser light is a very natural addition to e + e - linear colliders. In this report, we consider this option for the TESLA project. Recent study has shown that the horizontal emittance in the TESLA damping ring can be further decreased by a factor of four. In this case, the γγ luminosity in the high energy part of spectrum can reach about (1/3)L e + e - . Typical cross-sections of interesting processes in γγ collisions are higher than those in e + e - collisions by about one order of magnitude, so the number of events in γγ collisions will be more than that in e + e - collisions. Photon colliders can, certainly, give additional information and they are the best for the study of many phenomena. The main question is now the technical feasibility. The key new element in photon colliders is a very powerful laser system. An external optical cavity is a promising approach for the TESLA project. A free electron laser is another option. However, a more straightforward solution is ''an optical storage ring (optical trap)'' with a diode pumped solid state laser injector which is today technically feasible. This paper briefly reviews the status of a photon collider based on the linear collider TESLA, its possible parameters and existing problems

  13. Tesla Roadsterin vauriokorjaus

    OpenAIRE

    Hiltunen, Santeri

    2016-01-01

    Insinöörityössä perehdyttiin Tesla-sähköauton rakenteeseen sekä korjaamiseen, sähkötyö-turvallisuuteen sekä sähkötekniikkaan. Työn tavoitteena on selvittää, mitä laki vaatii sähköauton korjaamiseen, ja kuinka saada varaosia ja ohjeita ajoneuvoon, jolla ei ole Suomessa maahantuojaa. Lisäksi tavoitteena oli selvittää, minkälainen auto on kyseessä sekä mitä materiaaleja autoon on käytetty. Työssä korjattiin takaosasta mekaanisilta osiltaan vaurioitunut Tesla Roadster -merkkinen sähköaut...

  14. Nikola Tesla and robotics

    Directory of Open Access Journals (Sweden)

    Vukobratović Miomir

    2006-01-01

    Full Text Available The paper analyzes some of Tesla's works and his most remarkable views concerning the problem of formulating theoretical bases of automatic control. As a tribute to Tesla's work on remote control of automated systems, as well to his (at the time far-seeing visions, special attention is paid to solving complex problem of control and feedback application. A more detailed discussion of the way and origin of formulating theoretical bases of automatic control are given. Besides, in more detail are presented the related pioneering works of Professor Nicholas Bernstein, great Russian physiologist who formulated the basic rules of the self-regulating movements of the man. Bernstein has achievements of highest scientific significance that has been in a direct function of identifying and proving the priority of his pioneering contributions in the domain of feedback, i.e. control and principles of cybernetics.

  15. Superconducting TESLA cavities

    Directory of Open Access Journals (Sweden)

    B. Aune

    2000-09-01

    Full Text Available The conceptional design of the proposed linear electron-positron collider TESLA is based on 9-cell 1.3 GHz superconducting niobium cavities with an accelerating gradient of E_{acc}≥25 MV/m at a quality factor Q_{0}≥5×10^{9}. The design goal for the cavities of the TESLA Test Facility (TTF linac was set to the more moderate value of E_{acc}≥15 MV/m. In a first series of 27 industrially produced TTF cavities the average gradient at Q_{0}=5×10^{9} was measured to be 20.1±6.2 MV/m, excluding a few cavities suffering from serious fabrication or material defects. In the second production of 24 TTF cavities, additional quality control measures were introduced, in particular, an eddy-current scan to eliminate niobium sheets with foreign material inclusions and stringent prescriptions for carrying out the electron-beam welds. The average gradient of these cavities at Q_{0}=5×10^{9} amounts to 25.0±3.2 MV/m with the exception of one cavity suffering from a weld defect. Hence only a moderate improvement in production and preparation techniques will be needed to meet the ambitious TESLA goal with an adequate safety margin. In this paper we present a detailed description of the design, fabrication, and preparation of the TESLA Test Facility cavities and their associated components and report on cavity performance in test cryostats and with electron beam in the TTF linac. The ongoing research and development towards higher gradients is briefly addressed.

  16. TESLA accelerator installation

    International Nuclear Information System (INIS)

    Neskovic, N.; Ostojic, R.; Susini, A.; Milinkovic, Lj.; Ciric, D.; Dobrosavljevic, A.; Brajuskovic, B.; Cirkovic, S.; Bojovic, B.; Josipovic, M.

    1992-01-01

    The TESLA accelerator Installation is described. Its main parts are the VINCY Cyclotron, the multiply charged heavy-ion mVINIS Ion Source, and the negative light-ion pVINIS Ion Source. The Installation should be the principal installation of a regional center for basic and applied research in nuclear physics, atomic physics, surface physics and solid state physics, for production of radioisotopes, for research and therapy in nuclear medicine. The first extraction of the ion beam from the Cyclotron is planned for 1995. (R.P.) 3 refs.; 1 fig

  17. The Superconducting TESLA Cavities

    CERN Document Server

    Aune, B.; Bloess, D.; Bonin, B.; Bosotti, A.; Champion, M.; Crawford, C.; Deppe, G.; Dwersteg, B.; Edwards, D.A.; Edwards, H.T.; Ferrario, M.; Fouaidy, M.; Gall, P-D.; Gamp, A.; Gössel, A.; Graber, J.; Hubert, D.; Hüning, M.; Juillard, M.; Junquera, T.; Kaiser, H.; Kreps, G.; Kuchnir, M.; Lange, R.; Leenen, M.; Liepe, M.; Lilje, L.; Matheisen, A.; Möller, W-D.; Mosnier, A.; Padamsee, H.; Pagani, C.; Pekeler, M.; Peters, H-B.; Peters, O.; Proch, D.; Rehlich, K.; Reschke, D.; Safa, H.; Schilcher, T.; Schmüser, P.; Sekutowicz, J.; Simrock, S.; Singer, W.; Tigner, M.; Trines, D.; Twarowski, K.; Weichert, G.; Weisend, J.; Wojtkiewicz, J.; Wolff, S.; Zapfe, K.

    2000-01-01

    The conceptional design of the proposed linear electron-positron colliderTESLA is based on 9-cell 1.3 GHz superconducting niobium cavities with anaccelerating gradient of Eacc >= 25 MV/m at a quality factor Q0 > 5E+9. Thedesign goal for the cavities of the TESLA Test Facility (TTF) linac was set tothe more moderate value of Eacc >= 15 MV/m. In a first series of 27industrially produced TTF cavities the average gradient at Q0 = 5E+9 wasmeasured to be 20.1 +- 6.2 MV/m, excluding a few cavities suffering fromserious fabrication or material defects. In the second production of 24 TTFcavities additional quality control measures were introduced, in particular aneddy-current scan to eliminate niobium sheets with foreign material inclusionsand stringent prescriptions for carrying out the electron-beam welds. Theaverage gradient of these cavities at Q0 = 5E+9 amounts to 25.0 +- 3.2 MV/mwith the exception of one cavity suffering from a weld defect. Hence only amoderate improvement in production and preparation technique...

  18. TESLA Test Facility. Status

    International Nuclear Information System (INIS)

    Aune, B.

    1996-01-01

    The TESLA Test Facility (TTF), under construction at DESY by an international collaboration, is an R and D test bed for the superconducting option for future linear e+/e-colliders. It consists of an infrastructure to process and test the cavities and of a 500 MeV linac. The infrastructure has been installed and is fully operational. It includes a complex of clean rooms, an ultra-clean water plant, a chemical etching installation and an ultra-high vacuum furnace. The linac will consist of four cryo-modules, each containing eight 1 meter long nine-cell cavities operated at 1.3 GHz. The base accelerating field is 15 MV/m. A first injector will deliver a low charge per bunch beam, with the full average current (8 mA in pulses of 800 μs). A more powerful injector based on RF gun technology will ultimately deliver a beam with high charge and low emittance to allow measurements necessary to qualify the TESLA option and to demonstrate the possibility of operating a free electron laser based on the Self-Amplified-Spontaneous-Emission principle. Overview and status of the facility will be given. Plans for the future use of the linac are presented. (R.P.)

  19. [70 years of Nikola Tesla studies].

    Science.gov (United States)

    Juznic, Stanislav

    2013-01-01

    Nikola Tesla's studies of chemistry are described including his not very scholarly affair in Maribor. After almost a century and half of hypothesis at least usable scenario of Tesla's life and "work" in Maribor is provided. The chemistry achievements of Tesla's most influential professors Martin Sekulić and Tesla's Graz professors are put into the limelight. The fact that Tesla in Graz studied on the technological chemistry Faculty of Polytechnic is focused.

  20. TESLA & ILC Cryomodules

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, T. J. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Weisend, II, J. G. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2016-01-01

    The TESLA collaboration developed a unique variant of SRF cryomodule designs, the chief feature being use of the large, low pressure helium vapor return pipe as the structural support backbone of the cryomodule. Additional innovative features include all cryogenic piping within the cryomodule (no parallel external cryogenic transfer line), long strings of RF cavities within a single cryomodule, and cryomodules connected in series. Several projects, including FLASH and XFEL at DESY, LCLS-II at SLAC, and the ILC technical design have adopted this general design concept. Advantages include saving space by eliminating the external transfer line, relatively tight packing of RF cavities along the beamline due to fewer warm-cold transitions, and potentially lower costs. However, a primary disadvantage is the relative lack of independence for warm-up, replacement, and cool-down of individual cryomodules.

  1. Nikola Tesla: the Moon's rotation.

    Science.gov (United States)

    Tomić, A.; Jovanović, B. S.

    1993-09-01

    The review of three articles by N. Tesla, published in the year 1919 in the journal "Electrical experimenter" is given, with special reference to the astronomical contents and to circumstances in which they appeared.

  2. [Nikola Tesla in medicine, too].

    Science.gov (United States)

    Hanzek, Branko; Jakobović, Zvonimir

    2007-12-01

    Using primary and secondary sources we have shown in this paper the influence of Nikola Tesla's work on the field of medicine. The description of his experiments conduced within secondary-school education programs aimed to present the popularization of his work in Croatia. Although Tesla was dedicated primarily to physics and was not directly involved in biomedical research, his work significantly contributed to paving the way of medical physics particularly radiology and high-frequency electrotherapy.

  3. FT-ICR MS analysis of blended pine-microalgae feedstock HTL biocrudes

    Energy Technology Data Exchange (ETDEWEB)

    Jarvis, Jacqueline M.; Billing, Justin M.; Corilo, Yuri E.; Schmidt, Andrew J.; Hallen, Richard T.; Schaub, Tanner M.

    2018-03-01

    Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) is utilized for direct comparison of the chemical composition of biocrudes generated from the hydrothermal liquefaction of 100% pine, 100% algae, 75:25 pine:algae, and 50:50 pine:algae feedstocks. This analysis reveals that the of the 72:25 and 50:50 pine:algal HTL biocrudes is essentially a composite of the two parent feeds (i.e., pine and algae) with a lower relative abundance of Ox species and a higher relative abundance of nitrogen-containing species than the pine HTL biocrude. Alternatively, the biocrude blends have a lower relative abundance of nitrogen-containing species where N>2 than the algal HTL biocrude. The 75:25 pine:algal HTL biocrude has more elemental formulae in common with the pine HTL biocrude than the 50:50 blend; however, both blends have more elemental formulae in common with the algal HTL biocrude. Interestingly, >20% of the elemental formulae assigned to monoisotopic peaks within the 75:25 and 50:50 biocrude blends are species not present in either the pine or algal HTL biocrudes. The highest relative abundance of these new species belong to the N2O4-6 classes, which correspond to heteroatom classes with a moderate number of nitrogen atoms and higher number of oxygen atoms per molecules than the species within the pure algal HTL biocrude. Compositionally, the novel species have the same structural motif but are of higher DBE and carbon numbers than the species within the algal HTL biocrude. These original species are most likely generated from reactions between molecules from both feeds, which results in compounds wotj higher oxygen content than typically seen in the algal HTL biocrude but also higher nitrogen contents than observed in the pine HTL biocrude.

  4. The TESLA physics program

    CERN Document Server

    Behnke, T

    2002-01-01

    The TESLA accelerator concept is based on superconducting cavities, which are operated at comparatively low frequencies (L-Band, 1.3 GHz) . Superconducting cavities in connection with the low frequency offer a number of significant advantages. Because the power dissipation in the superconducting cavity walls is very small, the accelerating field can be produced with long, low peak-power RF pulses. Thus the total power consumption of the accelerator can be kept at an acceptable limit, while still maintaining a high current and a long bunch train in the machine. In fact it is possible to use a long RF pulse (of 1 ms length) and large inter-bunch spacing within one pulse (337 ns at E/sub cms/ = 500 GeV). This allows collisions with zero- crossing angle at the experiment, and gives enough time between two bunches to operate a fast feedback system to maintain stable collisions. Even more important, the relatively low RF frequency results in significant smaller wake field effects than at machine operating at larger...

  5. TESLA superconducting RF cavity development

    International Nuclear Information System (INIS)

    Koepke, K.

    1995-01-01

    The TESLA collaboration has made steady progress since its first official meeting at Cornell in 1990. The infrastructure necessary to assemble and test superconducting rf cavities has been installed at the TESLA Test Facility (TTF) at DESY. 5-cell, 1.3 GHz cavities have been fabricated and have reached accelerating fields of 25 MV/m. Full sized 9-cell copper cavities of TESLA geometry have been measured to verify the higher order modes present and to evaluate HOM coupling designs. The design of the TESLA 9-cell cavity has been finalized and industry has started delivery. Two prototype 9-cell niobium cavities in their first tests have reached accelerating fields of 10 MV/m and 15 MV/m in a vertical dewar after high peak power (HPP) conditioning. The first 12 m TESLA cryomodule that will house 8 9-cell cavities is scheduled to be delivered in Spring 1995. A design report for the TTF is in progress. The TTF test linac is scheduled to be commissioned in 1996/1997. (orig.)

  6. Tesla man out of time

    CERN Document Server

    Cheney, Margaret

    1981-01-01

    Called a madman by some, a genius by others, and an enigma by nearly everyone, Nikola Tesla created astonishing, world-transforming devises that were virtually without theoretical precedent. Tesla not only discovered the rotating magnetic field, the basis of most alternating current machinery, but also introduced the fundamentals of robotry, computers, and missile science and helped pave the way for such technologies as satellites, microwaves, beam weapons, and nuclear fusion. Almost supernaturally gifted, Tesla was also unusually erratic, flamboyant, and neurotic. He was J. P. Morgan's client, counted Mark Twain as a friend, and considered Thomas Edison an enemy. But above all, he was the hero and mentor to many of the last century's most famous scientists. In a meticulously researched, engagingly written biography, Margaret Cheney presents the many different dimensions of this extraordinary man, capturing his human qualities and quirks as she chronicles a lifetime of discoveries that continue to alter our ...

  7. Emittance damping considerations for TESLA

    International Nuclear Information System (INIS)

    Floettmann, K.; Rossbach, J.

    1993-03-01

    Two schemes are considered to avoid very large damping rings for TESLA. The first (by K.F.) makes use of the linac tunnel to accomodate most of the damping 'ring' structure, which is, in fact, not a ring any more but a long linear structure with two small bends at each of its ends ('dog-bone'). The other scheme (by J.R.) is based on a positron (or electron, respectively) recycling scheme. It makes use of the specific TESLA property, that the full bunch train is much longer (240 km) than the linac length. The spent beams are recycled seven times after interaction, thus reducing the number of bunches to be stored in the damping ring by a factor of eight. Ultimately, this scheme can be used to operate TESLA in a storage ring mode ('storage linac'), with no damping ring at all. Finally, a combination of both schemes is considered. (orig.)

  8. TESLA-N electron scattering with polarized targets at TESLA

    International Nuclear Information System (INIS)

    Korotokov, V.

    2001-01-01

    Measurements of polarized eN scattering can be realized at the TESLA linear collider facility at DESY with luminosities that are about two orders of magnitude higher than those expected for other experiments at comparable energies. A large variety of polarized parton distribution and fragmentation functions can be determined with unprecedented accuracy, many of them for the first time

  9. Atmospheric pressure chemical ionization Fourier transform ion cyclotron resonance mass spectrometry for complex thiophenic mixture analysis

    KAUST Repository

    Hourani, Nadim; Andersson, Jan T.; Mö ller, Isabelle; Amad, Maan H.; Witt, Matthí as; Sarathy, Mani

    2013-01-01

    oil (VGO) and injected using the same method. The samples were analyzed using Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS). RESULTS PASH model analytes were successfully ionized and mainly [M + H]+ ions were produced. The same

  10. Nikola Tesla Educational Opportunity School.

    Science.gov (United States)

    Design Cost Data, 2001

    2001-01-01

    Describes the architectural design, costs, general description, and square footage data for the Nikola Tesla Educational Opportunity School in Colorado Springs, Colorado. A floor plan and photos are included along with a list of manufacturers and suppliers used for the project. (GR)

  11. The Legacy of Nikola Tesla

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 3. The Legacy of Nikola Tesla - The AC System that he Helped to Usher in. D P Sen Gupta. General Article Volume 12 Issue 3 March 2007 pp 54-69. Fulltext. Click here to view fulltext PDF. Permanent link:

  12. The Legacy of Nikola Tesla

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 4. The Legacy of Nikola Tesla - AC Power System and its Growth in India. D P Sen Gupta. General Article Volume 12 Issue 4 April 2007 pp 69-79. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. ICR studies of some anionic gas phase reactions and FTICR software design

    International Nuclear Information System (INIS)

    Noest, A.J.

    1983-01-01

    This thesis consists of two parts. Part one (Chs. 1-5) reports experimental results from mostly drift-cell ICR studies of negative ion-molecule reactions; part two (Chs. 6-11) concerns the design of software for an FTICR instrument. The author discusses successively: 1. ion cyclotron resonance spectrometry; 2. the gas phase allyl anion; 3. the (M-H) and (M-H2) anions from acetone; 4. negative ion-molecule reactions of aliphatic nitrites studied by cyclotron resonance; 5. homoconjugation versus charge-dipole interaction effects in the stabilization of carbanions in the gas phase; 6. the Fourier Transform ICR method; 7. the FTICR-software; 8. an efficient adaptive matcher filter for fast transient signals; 9. reduction of spectral peak height errors by time-domain weighing; 10. Chirp excitation; 11. Compact data storage. The book concludes with a Dutch and English summary (G.J.P.)

  14. Nucleonic instruments from VUPJT Tesla

    International Nuclear Information System (INIS)

    Smola, J.

    1986-01-01

    The instruments currently produced by Tesla Premysleni are listed and briefly characterized. They include a low level alpha-beta counter, an automatic low level alpha-beta counter, detection units for environmental sample counting, instruments for measuring specific activity of liquids and radon concentration in water, a radioactive aerosol meter, dose ratemeters, portable alpha-beta indicators for surface contamintion monitoring, neutron monitors, single-, two- and three-channel spectrometric units. (M.D.)

  15. Tesla - A Flash of a Genius

    Science.gov (United States)

    Teodorani, M.

    2005-10-01

    This book, which is entirely dedicated to the inventions of scientist Nikola Tesla, is divided into three parts: a) all the most important innovative technological creations from the alternate current to the death ray, Tesla research in fundamental physics with a particular attention to the concept of "ether", ball lightning physics; b) the life and the bright mind of Nikola Tesla and the reasons why some of his most recent findings were not accepted by the establishment; c) a critical discussion of the most important work by Tesla followers.

  16. Nell’anno di Nikola Tesla

    OpenAIRE

    Persida Lazarević Di Giacomo

    2006-01-01

    The 150th Anniversary Celebration of Nikola Tesla The paper deals with the 150th anniversary celebration of Nikola Tesla, the greatest ever Yugoslav scientist. Due to his origins, Tesla is contended between Serbia and Croatia, but he is also considered to be an American scientist since he registered most of his patents in the USA. Although there is some dissension between Serbia and Croatia regarding the historical facts about Tesla’s life, it can be asserted that Tesla appears to be an...

  17. Tesla coil theoretical model and experimental verification

    OpenAIRE

    Voitkans, Janis; Voitkans, Arnis

    2014-01-01

    Abstract – In this paper a theoretical model of a Tesla coil operation is proposed. Tesla coil is described as a long line with distributed parameters in a single-wired format, where the line voltage is measured against electrically neutral space. It is shown that equivalent two-wired scheme can be found for a single-wired scheme and already known long line theory can be applied to a Tesla coil. Formulas for calculation of voltage in a Tesla coil by coordinate and calculation of resonance fre...

  18. Determination of soyasaponins in Fagioli di Sarconi beans (Phaseolus vulgaris L.) by LC-ESI-FTICR-MS and evaluation of their hypoglycemic activity.

    Science.gov (United States)

    Bianco, Giuliana; Pascale, Raffaella; Carbone, Cecilia F; Acquavia, Maria A; Cataldi, Tommaso R I; Schmitt-Kopplin, Philippe; Buchicchio, Alessandro; Russo, Daniela; Milella, Luigi

    2018-02-01

    Soyasaponins are oleanene-type triterpenoid saponins, naturally occurring in many edible plants that have attracted a great deal of attention for their role in preventing chronic diseases. The aim of this study was to establish the distribution and the content of soyasaponins in 21 ecotypes of Fagioli di Sarconi beans (Phaseolus vulgaris, Leguminosae). High-performance reversed-phase liquid chromatography (RPLC) with positive electrospray ionization (ESI(+)) and Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS) in conjunction with infrared multiphoton dissociation (IRMPD) was applied for the unambiguous identification of soyasaponins Ba (m/z 959.5213, [C 48 H 79 O 19 ] + ), Bb (m/z 943.5273, [C 48 H 79 O 18 ] + ), Bd (m/z 957.5122, [C 48 H 77 O 19 ] + ), and Be (m/z 941.5166, [C 48 H 77 O 18 ] + ), which are the only commercially available reference standards. In addition, the several diagnostic product ions generated by IRMPD in the ICR-MS cell allowed us the putative identification of soyasaponins Bb' (m/z 797.4680, [C 42 H 69 O 14 ] + ), αg (m/z 1085.5544, [C 54 H 85 O 22 ] + ), βg (m/z 1069.5600, [C 54 H 85 O 21 ] + ), and γg (m/z 923.5009, [C 48 H 75 O 17 ] + ), establishing thus their membership in the soyasaponin group. Quantitative and semiquantitative analysis of identified soyasaponins were also performed by RPLC-ESI(+) FTICR-MS; the total concentration levels were found ranging from 83.6 ± 9.3 to 767 ± 37 mg/kg. In vitro hypoglycemic outcomes of four soyasaponin standards were evaluated; significant inhibitory activities were obtained with IC 50 values ranging from 1.5 ± 0.1 to 2.3 ± 0.2 μg/mL and 12.0 ± 1.1 to 29.4 ± 1.4 μg/mL for α-glucosidase and α-amylase, respectively. This study represents the first detailed investigation on the antidiabetic activity of bioactive constituents found in Fagioli di Sarconi beans. Graphical abstract The first detailed RPLC-ESI(+) FTICR-MS investigation of

  19. Use of ESI-FTICR-MS to Characterize Dissolved Organic Matter in Headwater Streams Draining Forest-Dominated and Pasture-Dominated Watersheds.

    Directory of Open Access Journals (Sweden)

    YueHan Lu

    Full Text Available Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS has proven to be a powerful technique revealing complexity and diversity of natural DOM molecules, but its application to DOM analysis in grazing-impacted agricultural systems remains scarce. In the present study, we presented a case study of using ESI-FTICR-MS in analyzing DOM from four headwater streams draining forest- or pasture-dominated watersheds in Virginia, USA. In all samples, most formulas were CHO compounds (71.8-87.9%, with other molecular series (CHOS, CHON, CHONS, and CHOP (N, S accounting for only minor fractions. All samples were dominated by molecules falling in the lignin-like region (H/C = 0.7-1.5, O/C = 0.1-0.67, suggesting the predominance of allochthonous, terrestrial plant-derived DOM. Relative to the two pasture streams, DOM formulas in the two forest streams were more similar, based on Jaccard similarity coefficients and nonmetric multidimensional scaling calculated from Bray-Curtis distance. Formulas from the pasture streams were characterized by lower proportions of aromatic formulas and lower unsaturation, suggesting that the allochthonous versus autochthonous contributions of organic matter to streams were modified by pasture land use. The number of condensed aromatic structures (CAS was higher for the forest streams, which is possibly due to the controlled burning in the forest-dominated watersheds and suggests that black carbon was mobilized from soils to streams. During 15-day biodegradation experiments, DOM from the two pasture streams was altered to a greater extent than DOM from the forest streams, with formulas with H/C and O/C ranges similar to protein (H/C = 1.5-2.2, O/C = 0.3-0.67, lipid (H/C = 1.5-2.0, O/C = 0-0.3, and unsaturated hydrocarbon (H/C = 0.7-1.5, O/C = 0-0.1 being the most bioreactive groups. Aromatic compound formulas including CAS were preferentially removed during combined light

  20. Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Analysis of Large Polymerases Chain Reaction Products

    International Nuclear Information System (INIS)

    Wunschel, David S.; Pasa Tolic, Ljiljana; Feng, Bingbing; Smith, Richard D.

    2000-01-01

    We have attempted to expand the size range of PCR products that can be analyzed by electroscopy ionization (ESI) Fourier transformion cyclotron resonance (FTICR) mass spectrometry. The mass measurement accuracy obtained illustrates that a signel base substitution could be identified at the size of PCR product with a 7 tesla ESI-FTICR

  1. The comparison of naturally weathered oil and artificially photo-degraded oil at the molecular level by a combination of SARA fractionation and FT-ICR MS

    International Nuclear Information System (INIS)

    Islam, Ananna; Cho, Yunju; Yim, Un Hyuk; Shim, Won Joon; Kim, Young Hwan; Kim, Sunghwan

    2013-01-01

    Highlights: • Weathered oils from the Hebei Spirit oil spill and photo degraded oils are compared. • We investigate changes of polar species at the molecular level by 15T FT-ICR MS. • Significant reduction of sulfur class compounds in saturates fraction is observed. • The relative abundance of protonated compounds (presumably basic nitrogen compounds) increase after degradation. • Changes of polar compounds occurred by natural and photo degradation are similar. -- Abstract: Two sets of oil samples, one obtained from different weathering stages of the M/V Hebei Spirit oil spill site and the other prepared by an in vitro photo-degradation experiment, were analyzed and compared at the molecular level by atmospheric pressure photo-ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). For a more detailed comparison at the molecular level, the oil samples were separated into saturate, aromatic, resin, and asphaltene (SARA) fractions before MS analysis. Gravimetric analysis of the SARA fractions revealed a decreased weight percentage of the aromatic fraction and an increased resin fraction in both sets of samples. Molecular-level investigations of the SARA fractions showed a significant reduction in the S 1 class in the saturate fraction and increase of S 1 O 1 class compounds with high DBE values in resin fraction. Levels of N 1 and N 1 O 1 class compounds resulting in protonated ions (presumably basic nitrogen compounds) increased after degradation compared to compounds generating molecular ions (presumably non-basic nitrogen compounds). This study revealed changes occurring in heteroatom polar species of crude oils such as sulfur and nitrogen containing compounds that have not been easily detected with conventional GC based techniques

  2. Cyclotron Phase-Coherent Ion Spatial Dispersion in a Non-Quadratic Trapping Potential is Responsible for FT-ICR MS at the Cyclotron Frequency

    Science.gov (United States)

    Nagornov, Konstantin O.; Kozhinov, Anton N.; Tsybin, Yury O.

    2018-01-01

    Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) at the cyclotron frequency instead of the reduced cyclotron frequency has been experimentally demonstrated using narrow aperture detection electrode (NADEL) ICR cells. Here, based on the results of SIMION simulations, we provide the initial mechanistic insights into the cyclotron frequency regime generation in FT-ICR MS. The reason for cyclotron frequency regime is found to be a new type of a collective motion of ions with a certain dispersion in the initial characteristics, such as pre-excitation ion velocities, in a highly non-quadratic trapping potential as realized in NADEL ICR cells. During ion detection, ions of the same m/z move in phase for cyclotron ion motion but out of phase for magnetron (drift) ion motion destroying signals at the fundamental and high order harmonics that comprise reduced cyclotron frequency components. After an initial magnetron motion period, ion clouds distribute into a novel type of structures - ion slabs, elliptical cylinders, or star-like structures. These structures rotate at the Larmor (half-cyclotron) frequency on a plane orthogonal to the magnetic field, inducing signals at the true cyclotron frequency on each of the narrow aperture detection electrodes. To eliminate the reduced cyclotron frequency peak upon dipolar ion detection, a number of slabs or elliptical cylinders organizing a star-like configuration are formed. In a NADEL ICR cell with quadrupolar ion detection, a single slab or an elliptical cylinder is sufficient to minimize the intensity of the reduced cyclotron frequency components, particularly the second harmonic. [Figure not available: see fulltext.

  3. The mechanism of reduced IgG/IgE-binding of β-lactoglobulin by pulsed electric field pretreatment combined with glycation revealed by ECD/FTICR-MS.

    Science.gov (United States)

    Yang, Wenhua; Tu, Zongcai; Wang, Hui; Zhang, Lu; Kaltashov, Igor A; Zhao, Yunlong; Niu, Chendi; Yao, Honglin; Ye, Wenfeng

    2018-01-24

    Bovine β-lactoglobulin (β-Lg) is a major allergen existing in milk and causes about 90% of IgE-mediated cow's milk allergies. Previous studies showed that pulsed electric field (PEF) treatment could partially unfold the protein, which may contribute to the improvement of protein glycation. In this study, the effect of PEF pretreatment combined with glycation on the IgG/IgE-binding ability and the structure of β-Lg was investigated. The result showed that PEF pretreatment combined with glycation significantly reduced the IgG and IgE binding abilities, which was attributed to the changes of secondary and tertiary structure and the increase in glycation sites and degree of substitution per peptide (DSP) value determined by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD/FTICR-MS). Unexpectedly, glycation sites (K47, K91 and K135) added by two mannose molecules were identified in glycated β-Lg with PEF pretreatment. Moreover, the results indicated that PEF pretreatment at 25 kV cm -1 for 60 μs promoted the reduction of IgG/IgE-binding capacity by increasing the glycation degree of β-Lg, whereas single PEF treatment under the same conditions markedly enhanced the IgG/IgE-binding ability by partially unfolding the structure of β-Lg. The results suggested that ECD/FTICR-MS could help us to understand the mechanism of reduction in the IgG/IgE-binding of β-Lg by structural characterization at the molecular level. Therefore, PEF pretreatment combined with glycation may provide an alternative method for β-Lg desensitization.

  4. Nell’anno di Nikola Tesla

    Directory of Open Access Journals (Sweden)

    Persida Lazarević Di Giacomo

    2006-12-01

    Full Text Available The 150th Anniversary Celebration of Nikola Tesla The paper deals with the 150th anniversary celebration of Nikola Tesla, the greatest ever Yugoslav scientist. Due to his origins, Tesla is contended between Serbia and Croatia, but he is also considered to be an American scientist since he registered most of his patents in the USA. Although there is some dissension between Serbia and Croatia regarding the historical facts about Tesla’s life, it can be asserted that Tesla appears to be an example of collaboration among the former Yugoslav countries. Tesla, however, deserves to be remembered as well as the author of autobiographical prose (My Inventions; Some Personal Recollections; A Strange Experience by Nikola Tesla and as the protagonist of many works published in Serbo-Croatian and in English, such as Miloš Crnjanski’s drama Tesla (1969 or The Hunger and Ecstasy of Vampires (1996 by Brian M. Stableford, for example. This fact should not be neglected and actually should be researched more fully.

  5. NIKOLA TESLA AND THE X-RAY

    OpenAIRE

    Rade R. Babic

    2005-01-01

    After professor Wilhelm Konrad Röntgen published his study of an x-ray discovery (Academy Bulletin, Berlin, 08. 11. 1895.), Nikola Tesla published his first study of an x-ray on the 11th of March in 1896. (X-ray, Electrical Review). Until the 11th of August in 1897 he had published ten studies on this subject. All Tesla,s x-ray studies were experimental, which is specific to his work. Studying the nature of the x-ray, he established a new medical branch-radiology. He wrote:” There’s no doubt...

  6. CERN: Ten-Tesla twin

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    An important step in the development of the high field superconducting magnets for CERN's proposed LHC proton collider came on 21 October when a 1 metre-long model of the proposed twin-dipole magnet produced a field of 10 Tesla in its two o beam apertures at the design temperature of 1.8K. The LHC designers have to plan for proton beams approaching 8 TeV to attain the right conditions for the quarks and gluons hidden deep inside protons to produce new physics. To contain these very high energy protons in the tight track of the 27-kilometre LEP tunnel would need the strongest magnetic bending power ever used in a full storage ring

  7. [Nikola Tesla: flashes of inspiration].

    Science.gov (United States)

    Villarejo-Galende, Albero; Herrero-San Martín, Alejandro

    2013-01-16

    Nikola Tesla (1856-1943) was one of the greatest inventors in history and a key player in the revolution that led to the large-scale use of electricity. He also made important contributions to such diverse fields as x-rays, remote control, radio, the theory of consciousness or electromagnetism. In his honour, the international unit of magnetic induction was named after him. Yet, his fame is scarce in comparison with that of other inventors of the time, such as Edison, with whom he had several heated arguments. He was a rather odd, reserved person who lived for his inventions, the ideas for which came to him in moments of inspiration. In his autobiography he relates these flashes with a number of neuropsychiatric manifestations, which can be seen to include migraine auras, synaesthesiae, obsessions and compulsions.

  8. Hydroforming of superconducting TESLA cavities

    International Nuclear Information System (INIS)

    Singer, W.; Kaiser, H.; Singer, X.

    2003-01-01

    Seamless fabrication of single-cell and multi-cell TESLA shape cavities by hydroforming has been developed at DESY. The forming takes place by expanding the seamless tube with internal water pressure while simultaneously swaging it axially. Tube radius and axial displacement are being computer controlled in accordance with results of FEM simulations and the experimentally obtained strain-stress curve of tube material. Several Nb single cell cavities have been produced. A first bulk Nb double cell cavity has been fabricated. The Nb seamless tubes have been produced by spinning and deep drawing. Surface treatment such as buffered chemical polishing, (BCP), electropolishing (EP), high pressure ultra pure water rinsing (HPR), annealing at 800degC and baking at ca. 150degC have been applied. The best single cell bulk Nb cavity has reached an accelerating gradient of Eacc > 42 MV/m after ca. 250 μm BCP and 100 μm EP. Several bimetallic NbCu single cell cavities of TESLA shape have been fabricated. The seamless tubes have been produced by explosive bonding and subsequent flow forming. The thicknesses of Nb and Cu layers in the tube wall are about 1 mm and 3 mm respectively. The RF performance of NbCu clad cavities is similar to that of bulk Nb cavities. The highest accelerating gradient achieved was 40 MV/m after ca. 180 μm BCP, annealing at 800degC and baking at 140degC for 30 hours. The degradation of the quality factor Qo after repeated quenching is moderate, after ca. 150 quenches it reaches the saturation point of Qo=1.4x10 10 at low field. This indicates that on the basis of RF performance and material costs the combination of hydroforming with tube cladding is a very promising option. (author)

  9. TeSLA e-assessment workshop

    NARCIS (Netherlands)

    Janssen, José

    2016-01-01

    Presentatie ten behoeve van de e-assessment workshop voor docenten van de Open Universiteit Nederland betrokken in de eerste TeSLA pilot. Topics: toetsfraude, toetsdesign, technologie voor authenticatie en verificatie van auteurschap.

  10. TESLA: Large Signal Simulation Code for Klystrons

    International Nuclear Information System (INIS)

    Vlasov, Alexander N.; Cooke, Simon J.; Chernin, David P.; Antonsen, Thomas M. Jr.; Nguyen, Khanh T.; Levush, Baruch

    2003-01-01

    TESLA (Telegraphist's Equations Solution for Linear Beam Amplifiers) is a new code designed to simulate linear beam vacuum electronic devices with cavities, such as klystrons, extended interaction klystrons, twistrons, and coupled cavity amplifiers. The model includes a self-consistent, nonlinear solution of the three-dimensional electron equations of motion and the solution of time-dependent field equations. The model differs from the conventional Particle in Cell approach in that the field spectrum is assumed to consist of a carrier frequency and its harmonics with slowly varying envelopes. Also, fields in the external cavities are modeled with circuit like equations and couple to fields in the beam region through boundary conditions on the beam tunnel wall. The model in TESLA is an extension of the model used in gyrotron code MAGY. The TESLA formulation has been extended to be capable to treat the multiple beam case, in which each beam is transported inside its own tunnel. The beams interact with each other as they pass through the gaps in their common cavities. The interaction is treated by modification of the boundary conditions on the wall of each tunnel to include the effect of adjacent beams as well as the fields excited in each cavity. The extended version of TESLA for the multiple beam case, TESLA-MB, has been developed for single processor machines, and can run on UNIX machines and on PC computers with a large memory (above 2GB). The TESLA-MB algorithm is currently being modified to simulate multiple beam klystrons on multiprocessor machines using the MPI (Message Passing Interface) environment. The code TESLA has been verified by comparison with MAGIC for single and multiple beam cases. The TESLA code and the MAGIC code predict the same power within 1% for a simple two cavity klystron design while the computational time for TESLA is orders of magnitude less than for MAGIC 2D. In addition, recently TESLA was used to model the L-6048 klystron, code

  11. Conduction-coupled Tesla transformer.

    Science.gov (United States)

    Reed, J L

    2015-03-01

    A proof-of-principle Tesla transformer circuit is introduced. The new transformer exhibits the high voltage-high power output signal of shock-excited transformers. The circuit, with specification of proper circuit element values, is capable of obtaining extreme oscillatory voltages. The primary and secondary portions of the circuit communicate solely by conduction. The destructive arcing between the primary and secondary inductors in electromagnetically coupled transformers is ubiquitous. Flashover is eliminated in the new transformer as the high-voltage inductors do not interpenetrate and so do not possess an annular volume of electric field. The inductors are remote from one another. The high voltage secondary inductor is isolated in space, except for a base feed conductor, and obtains earth by its self-capacitance to the surroundings. Governing equations, for the ideal case of no damping, are developed from first principles. Experimental, theoretical, and circuit simulator data are presented for the new transformer. Commercial high-temperature superconductors are discussed as a means to eliminate the counter-intuitive damping due to small primary inductances in both the electromagnetic-coupled and new conduction-coupled transformers.

  12. Technical challenges of superconductivity and cryogenics in pursuing TESLA-TTF

    International Nuclear Information System (INIS)

    Shu, Quan-Sheng

    1996-01-01

    TESLA (TeV Energy Superconducting Linear Accelerator) Collaboration is an international R ampersand D effort towards the development of an e + e - linear collider with 500 GeV center of mass by means of 20 km active superconducting accelerating structures at a frequency of 1.3 GHz. The ultimate challenges faced by the TESLA project are (1) to raise operational accelerating gradients to 25 MV/m from current world level of 5-10 MV/m, and (2) to reduce construction costs (cryomodules, klystrons, etc.) down to $2,000/MV from now about $40,000/MV. The TESLA Collaboration is building a prototype TESLA test facility (TTF) of a 500 MeV superconducting linear accelerator to establish the technical basis. TTF is presently under construction and will be commissioned at DESY in 1997, through the joint efforts of 24 laboratories from 8 countries. Significant progress has been made in reaching the high accelerating gradient of 25 MV/m in superconducting cavities, developing cryomodules and constructing TTF infrastructure, etc. This paper will briefly discuss the challenges being faced and review the progress achieved in the technical area of superconductivity and cryogenics by the TESLA Collaboration

  13. Non-enhanced MR imaging of cerebral aneurysms: 7 Tesla versus 1.5 Tesla.

    Science.gov (United States)

    Wrede, Karsten H; Dammann, Philipp; Mönninghoff, Christoph; Johst, Sören; Maderwald, Stefan; Sandalcioglu, I Erol; Müller, Oliver; Özkan, Neriman; Ladd, Mark E; Forsting, Michael; Schlamann, Marc U; Sure, Ulrich; Umutlu, Lale

    2014-01-01

    To prospectively evaluate 7 Tesla time-of-flight (TOF) magnetic resonance angiography (MRA) in comparison to 1.5 Tesla TOF MRA and 7 Tesla non-contrast enhanced magnetization-prepared rapid acquisition gradient-echo (MPRAGE) for delineation of unruptured intracranial aneurysms (UIA). Sixteen neurosurgical patients (male n = 5, female n = 11) with single or multiple UIA were enrolled in this trial. All patients were accordingly examined at 7 Tesla and 1.5 Tesla MRI utilizing dedicated head coils. The following sequences were obtained: 7 Tesla TOF MRA, 1.5 Tesla TOF MRA and 7 Tesla non-contrast enhanced MPRAGE. Image analysis was performed by two radiologists with regard to delineation of aneurysm features (dome, neck, parent vessel), presence of artifacts, vessel-tissue-contrast and overall image quality. Interobserver accordance and intermethod comparisons were calculated by kappa coefficient and Lin's concordance correlation coefficient. A total of 20 intracranial aneurysms were detected in 16 patients, with two patients showing multiple aneurysms (n = 2, n = 4). Out of 20 intracranial aneurysms, 14 aneurysms were located in the anterior circulation and 6 aneurysms in the posterior circulation. 7 Tesla MPRAGE imaging was superior over 1.5 and 7 Tesla TOF MRA in the assessment of all considered aneurysm and image quality features (e.g. image quality: mean MPRAGE7T: 5.0; mean TOF7T: 4.3; mean TOF1.5T: 4.3). Ratings for 7 Tesla TOF MRA were equal or higher over 1.5 Tesla TOF MRA for all assessed features except for artifact delineation (mean TOF7T: 4.3; mean TOF1.5T 4.4). Interobserver accordance was good to excellent for most ratings. 7 Tesla MPRAGE imaging demonstrated its superiority in the detection and assessment of UIA as well as overall imaging features, offering excellent interobserver accordance and highest scores for all ratings. Hence, it may bear the potential to serve as a high-quality diagnostic tool for pretherapeutic assessment and

  14. Practical aspects of trapped ion mass spectrometry, 5 applications of ion trapping devices

    CERN Document Server

    March, Raymond E

    2009-01-01

    Examines ion/neutral and ion/ion reactions, ion spectroscopy, and the structural characterization of proteins and peptides using quadropole ion trap mass spectrometry, Fourier transform - ion cyclotron resonance (FT-ICR) mass spectrometry, and traveling wave ion mobility mass spectrometry.

  15. TeSLA workshop betrouwbaar toetsen op afstand

    NARCIS (Netherlands)

    Brouns, Francis; Janssen, José

    2017-01-01

    Presentatie ten behoeve van workshop betrouwbaar toetsen op afstand voor docenten van de Open Universiteit Nederland betrokken in de derde TeSLA pilot. Topics: toetsfraude, toetsdesign, technologie voor authenticatie en verificatie van auteurschap, TeSLA instrumenten.

  16. TeSLA e-assessment workshop pilot 2

    OpenAIRE

    Janssen, José

    2017-01-01

    Presentatie ten behoeve van de e-assessment workshop voor docenten van de Open Universiteit Nederland betrokken in de tweede TeSLA pilot. Topics: toetsfraude, toetsdesign, technologie voor authenticatie en verificatie van auteurschap, TeSLA instrument.

  17. Improving mass measurement accuracy in mass spectrometry based proteomics by combining open source tools for chromatographic alignment and internal calibration.

    Science.gov (United States)

    Palmblad, Magnus; van der Burgt, Yuri E M; Dalebout, Hans; Derks, Rico J E; Schoenmaker, Bart; Deelder, André M

    2009-05-02

    Accurate mass determination enhances peptide identification in mass spectrometry based proteomics. We here describe the combination of two previously published open source software tools to improve mass measurement accuracy in Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS). The first program, msalign, aligns one MS/MS dataset with one FTICRMS dataset. The second software, recal2, uses peptides identified from the MS/MS data for automated internal calibration of the FTICR spectra, resulting in sub-ppm mass measurement errors.

  18. Ambient ionization mass spectrometry imaging for characterizing plant-microbe interactions using liquid extraction surface analysis (LESA)

    Science.gov (United States)

    Chu, R. K.; Anderton, C.; Weston, D. J.; Carrell, A. A.; Paša-Tolić, L.; Veličković, D.; Tfaily, M.

    2017-12-01

    The rhizosphere consists of a diverse community of plants, bacteria and fungi that are interacting with each other and with complex soil matrix they occupy. By studying the chemical signaling and processes that occur within this dynamic microenvironment, we will further our understanding of the symbiotic and competitive interaction within microbial communities. Field studies and bulk analyses shed light on the mechanisms by which environmental perturbations alter carbon and nitrogen cycling, but what is less clear are the intra- and interspecies molecular transformations and transactions between the different constituents within the rhizosphere. Chemical imaging by liquid extraction surface analysis mass spectrometry (LESA-MS) is a highly sensitive technique capable of providing both spatial and molecular information. Here, we examined the chemical interactions among a tripartite system of peat moss (Sphagnum fallax), cyanobacteria (Nostoc muscorium), and fungus (Trizdiaspa). We coupled LESA source to both a 15 Tesla Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS), for ultrahigh mass resolution and mass accuracy results, and a Thermo Velos-LTQ mass spectrometer, for tandem MS of selected molecules to increase confidence in molecular identifications. With LESA-MS approach we spatially probed the tripartite interactions and isolated cultures using a coordinate system that can be mapped back and overlaid onto the original image. Using this method, we mapped an array of metabolic distributions within the model sphagnum microbiome. For instance, we identified carbendazim, an anti-fungal agent, distributed within the interaction zone between the bacteria and fungi, while glyceropcholine and sucrose were localized within the sphagnum and fungus interaction zone. Further analysis will look into larger metabolites, lipids, and small proteins.

  19. About the origin of matter - the TESLA project

    International Nuclear Information System (INIS)

    Heuer, R.D.

    2004-01-01

    An introduction to the TESLA project is given. After a general introduction to the standard model of elementary particles together with some possible extension the scientific potential of TESLA is described with special regards to the production of Higgs bosons and supersymmetric particles. Finally the technology of TESLA is considered. (HSI)

  20. MODERN ELECTRIC CARS OF TESLA MOTORS COMPANY

    OpenAIRE

    O. F. Vynakov; E. V. Savolova; A. I. Skrynnyk

    2016-01-01

    This overview article shows the advantages of a modern electric car as compared with internal combustion cars by the example of the electric vehicles of Tesla Motors Company. It (в смысле- статья) describes the history of this firm, provides technical and tactical characteristics of three modifications of electric vehicles produced by Tesla Motors. Modern electric cars are not less powerful than cars with combustion engines both in speed and acceleration amount. They are reliable, economical ...

  1. Tesla inventor of the electrical age

    CERN Document Server

    Carlson, W Bernard

    2013-01-01

    Nikola Tesla was a major contributor to the electrical revolution that transformed daily life at the turn of the twentieth century. His inventions, patents, and theoretical work formed the basis of modern AC electricity, and contributed to the development of radio and television. Like his competitor Thomas Edison, Tesla was one of America's first celebrity scientists, enjoying the company of New York high society and dazzling the likes of Mark Twain with his electrical demonstrations. An astute self-promoter and gifted showman, he cultivated a public image of the eccentric genius. Even at t

  2. Tesla-transformer-type electron beam accelerator

    International Nuclear Information System (INIS)

    Liu Jinliang; Zhong Huihuang; Tan Qimei; Li Chuanlu; Zhang Jiande

    2002-01-01

    An electron-beam Tesla-transformer accelerator is described. It consists of the primary storage energy system. Tesla transformer, oil Blumlein pulse form line, and the vacuum diode. The experiments of initial stage showed that diode voltage rises up to about 500 kV with an input of 20 kV and the maximum electron-beam current is about 9 kA, the pulse width is about 50 ns. This device can operate stably and be set up easily

  3. Energy Spread Sources in TESLA and TTF

    International Nuclear Information System (INIS)

    Mosnier, A.; Tessier, J.M.

    1995-03-01

    The beam energy spread in the TESLA linac must be small enough to limit the emittance dilution due to the dispersive effects. This report summarizes the major sources of energy spread both for the TESLA linac and the TTF linac, where these estimations will be carefully checked with beam experiments. The first part recalls the intra-bunch energy spread while the second part looks into the bunch-to-bunch energy spread induced by rf field fluctuations within the bunch train and from pulse-to-pulse. (author). 3 refs., 4 figs

  4. Fourier transform ion cyclotron resonance mass spectrometry

    Science.gov (United States)

    Marshall, Alan G.

    1998-06-01

    As for Fourier transform infrared (FT-IR) interferometry and nuclear magnetic resonance (NMR) spectroscopy, the introduction of pulsed Fourier transform techniques revolutionized ion cyclotron resonance mass spectrometry: increased speed (factor of 10,000), increased sensitivity (factor of 100), increased mass resolution (factor of 10,000-an improvement not shared by the introduction of FT techniques to IR or NMR spectroscopy), increased mass range (factor of 500), and automated operation. FT-ICR mass spectrometry is the most versatile technique for unscrambling and quantifying ion-molecule reaction kinetics and equilibria in the absence of solvent (i.e., the gas phase). In addition, FT-ICR MS has the following analytically important features: speed (~1 second per spectrum); ultrahigh mass resolution and ultrahigh mass accuracy for analysis of mixtures and polymers; attomole sensitivity; MSn with one spectrometer, including two-dimensional FT/FT-ICR/MS; positive and/or negative ions; multiple ion sources (especially MALDI and electrospray); biomolecular molecular weight and sequencing; LC/MS; and single-molecule detection up to 108 Dalton. Here, some basic features and recent developments of FT-ICR mass spectrometry are reviewed, with applications ranging from crude oil to molecular biology.

  5. Semi-Targeted Analysis of Complex Matrices by ESI FT-ICR MS or How an Experimental Bias may be Used as an Analytical Tool

    Science.gov (United States)

    Hertzog, Jasmine; Carré, Vincent; Dufour, Anthony; Aubriet, Frédéric

    2018-03-01

    Ammonia is well suited to favor deprotonation process in electrospray ionization mass spectrometry (ESI-MS) to increase the formation of [M - H]-. Nevertheless, NH3 may react with carbonyl compounds (aldehyde, ketone) and bias the composition description of the investigated sample. This is of significant importance in the study of complex mixture such as oil or bio-oil. To assess the ability of primary amines to form imines with carbonyl compounds during the ESI-MS process, two aldehydes (vanillin and cinnamaldehyde) and two ketones (butyrophenone and trihydroxyacetophenone) have been infused in an ESI source with ammonia and two different amines (aniline and 3-chloronaniline). The (+) ESI-MS analyses have demonstrated the formation of imine whatever the considered carbonyl compound and the used primary amine, the structure of which was extensively studied by tandem mass spectrometry. Thus, it has been established that the addition of ammonia, in the solution infused in an ESI source, may alter the composition description of a complex mixture and leads to misinterpretations due to the formation of imines. Nevertheless, this experimental bias can be used to identify the carbonyl compounds in a pyrolysis bio-oil. As we demonstrated, infusion of the bio-oil with 3-chloroaniline in ESI source leads to specifically derivatized carbonyl compounds. Thanks to their chlorine isotopic pattern and the high mass measurement accuracy, (+) ESI Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) unambiguously highlighted them from the numerous CxHyOz bio-oil components. These results offer a new perspective into the detailed molecular structure of complex mixtures such as bio-oils. [Figure not available: see fulltext.

  6. Revealing Ligand Binding Sites and Quantifying Subunit Variants of Noncovalent Protein Complexes in a Single Native Top-Down FTICR MS Experiment

    Science.gov (United States)

    Li, Huilin; Wongkongkathep, Piriya; Van Orden, Steve L.; Ogorzalek Loo, Rachel R.; Loo, Joseph A.

    2014-12-01

    "Native" mass spectrometry (MS) has been proven to be increasingly useful for structural biology studies of macromolecular assemblies. Using horse liver alcohol dehydrogenase (hADH) and yeast alcohol dehydrogenase (yADH) as examples, we demonstrate that rich information can be obtained in a single native top-down MS experiment using Fourier transform ion cyclotron mass spectrometry (FTICR MS). Beyond measuring the molecular weights of the protein complexes, isotopic mass resolution was achieved for yeast ADH tetramer (147 kDa) with an average resolving power of 412,700 at m/z 5466 in absorption mode, and the mass reflects that each subunit binds to two zinc atoms. The N-terminal 89 amino acid residues were sequenced in a top-down electron capture dissociation (ECD) experiment, along with the identifications of the zinc binding site at Cys46 and a point mutation (V58T). With the combination of various activation/dissociation techniques, including ECD, in-source dissociation (ISD), collisionally activated dissociation (CAD), and infrared multiphoton dissociation (IRMPD), 40% of the yADH sequence was derived directly from the native tetramer complex. For hADH, native top-down ECD-MS shows that both E and S subunits are present in the hADH sample, with a relative ratio of 4:1. Native top-down ISD of the hADH dimer shows that each subunit (E and S chains) binds not only to two zinc atoms, but also the NAD/NADH ligand, with a higher NAD/NADH binding preference for the S chain relative to the E chain. In total, 32% sequence coverage was achieved for both E and S chains.

  7. Nikola Tesla, the Ether and his Telautomaton

    Science.gov (United States)

    Milar, Kendall

    2014-03-01

    In the nineteenth century physicists' understanding of the ether changed dramatically. New developments in thermodynamics, energy physics, and electricity and magnetism dictated new properties of the ether. These have traditionally been examined from the perspective of the scientists re-conceptualizing the ether. However Nikola Tesla, a prolific inventor and writer, presents a different picture of nineteenth century physics. Alongside the displays that showcased his inventions he presented alternative interpretations of physical, physiological and even psychical research. This is particularly evident in his telautomaton, a radio remote controlled boat. This invention and Tesla's descriptions of it showcase some of his novel interpretations of physical theories. He offered a perspective on nineteenth century physics that focused on practical application instead of experiment. Sometimes the understanding of physical theories that Tesla reached was counterproductive to his own inventive work; other times he offered new insights. Tesla's utilitarian interpretation of physical theories suggests a more scientifically curious and invested inventor than previously described and a connection between the scientific and inventive communities.

  8. Magnetic resonance examinations at two Tesla

    International Nuclear Information System (INIS)

    Grabbe, E.; Maas, R.; Heller, M.; Denkhaus, H.; Buecheler, E.

    1986-01-01

    After having used a 2 Tesla prototype whole body scanner for about one and a half years, it is now possible to comment on the clinical value of high field strengths. The methods and techniques employed are described. The problems arising from high field strengths are discussed and their effect on clinical diagnosis is indicated. (orig.) [de

  9. Beam dynamic issues in TESLA damping ring

    International Nuclear Information System (INIS)

    Shiltsev, V.

    1996-05-01

    In this paper we study general requirements on impedances of the linear collider TESLA damping ring design. Quantitative consideration is performed for 17-km long ''dog-bone'' ring. Beam dynamics in alternative options of 6.3 and 2.3-km long damping rings is briefly discussed. 5 refs., 2 tabs

  10. Novel techniques for 7 tesla breast MRI

    NARCIS (Netherlands)

    van der Velden, T.A.

    2017-01-01

    This thesis introduced several new techniques to the field of 7 tesla breast MRI, enabling high field multi-parametric MR imaging and, potentially, patient specific treatment planning. Chapter 2 described the development of a RF coil setup for bilateral breast MR imaging and 31P spectroscopy. This

  11. Structural Characterization of a Thrombin-Aptamer Complex by High Resolution Native Top-Down Mass Spectrometry

    Science.gov (United States)

    Zhang, Jiang; Loo, Rachel R. Ogorzalek; Loo, Joseph A.

    2017-09-01

    Native mass spectrometry (MS) with electrospray ionization (ESI) has evolved as an invaluable tool for the characterization of intact native proteins and non-covalently bound protein complexes. Here we report the structural characterization by high resolution native top-down MS of human thrombin and its complex with the Bock thrombin binding aptamer (TBA), a 15-nucleotide DNA with high specificity and affinity for thrombin. Accurate mass measurements revealed that the predominant form of native human α-thrombin contains a glycosylation mass of 2205 Da, corresponding to a sialylated symmetric biantennary oligosaccharide structure without fucosylation. Native MS showed that thrombin and TBA predominantly form a 1:1 complex under near physiological conditions (pH 6.8, 200 mM NH4OAc), but the binding stoichiometry is influenced by the solution ionic strength. In 20 mM ammonium acetate solution, up to two TBAs were bound to thrombin, whereas increasing the solution ionic strength destabilized the thrombin-TBA complex and 1 M NH4OAc nearly completely dissociated the complex. This observation is consistent with the mediation of thrombin-aptamer binding through electrostatic interactions and it is further consistent with the human thrombin structure that contains two anion binding sites on the surface. Electron capture dissociation (ECD) top-down MS of the thrombin-TBA complex performed with a high resolution 15 Tesla Fourier transform ion cyclotron resonance (FTICR) mass spectrometer showed the primary binding site to be at exosite I located near the N-terminal sequence of the heavy chain, consistent with crystallographic data. High resolution native top-down MS is complementary to traditional structural biology methods for structurally characterizing native proteins and protein-DNA complexes. [Figure not available: see fulltext.

  12. Achievement of 35 MV/m in the superconducting nine-cell cavities for TESLA

    International Nuclear Information System (INIS)

    Lilje, L.; Kostin, D.; Matheisen, A.; Moeller, W.D.; Proch, D.; Reschke, D.; Simrock, S.; Twarowski, K.; Kako, E.; Saito, K.; Schmueser, P.; Suzuki, T.

    2004-01-01

    The tera electronvolt superconducting linear accelerator TESLA is the only linear electron-positron collider project based on superconductor technology for particle acceleration. In the first stage with 500 GeV center-of-mass energy an accelerating field of 23.4 MV/m is needed in the superconducting niobium cavities which are operated at a temperature of 2 K and a quality factor Q 0 of 10 10 . This performance has been reliably achieved in the cavities of the TESLA test facility (TTF) accelerator. The upgrade of TESLA to 800 GeV requires accelerating gradients of 35 MV/m. Using an improved cavity treatment by electrolytic polishing it has been possible to raise the gradient to 35 - 43 MV/m in single cell resonators. Here we report on the successful transfer of the electropolishing technique to multi-cell cavities. Presently four nine-cell cavities have achieved 35 MV/m at Q 0 ≥ 5 x 10 9 , and a fifth cavity could be excited to 39 MV/m. In two high-power tests it could be verified that EP-cavities preserve their excellent performance after welding into the helium cryostat and assembly of the high-power coupler. One cavity has been operated for 1100 hours at the TESLA-800 gradient of 35 MV/m and 57 hours at 36 MV/m without loss in performance. (orig.)

  13. 76 FR 60124 - Tesla Motors, Inc.; Grant of Petition for Temporary Exemption From the Electronic Stability...

    Science.gov (United States)

    2011-09-28

    ...-0110] Tesla Motors, Inc.; Grant of Petition for Temporary Exemption From the Electronic Stability... notice grants the petition of Tesla Motors, Inc. (Tesla) for the temporary exemption of its Roadster... procedures in 49 CFR Part 555, Tesla Motors, Inc. (Tesla) submitted a petition dated June 7, 2011 asking the...

  14. MODERN ELECTRIC CARS OF TESLA MOTORS COMPANY

    Directory of Open Access Journals (Sweden)

    O. F. Vynakov

    2016-08-01

    Full Text Available This overview article shows the advantages of a modern electric car as compared with internal combustion cars by the example of the electric vehicles of Tesla Motors Company. It (в смысле- статья describes the history of this firm, provides technical and tactical characteristics of three modifications of electric vehicles produced by Tesla Motors. Modern electric cars are not less powerful than cars with combustion engines both in speed and acceleration amount. They are reliable, economical and safe in operation. With every year the maximum range of an electric car is increasing and its battery charging time is decreasing.Solving the problem of environmental safety, the governments of most countries are trying to encourage people to switch to electric cars by creating subsidy programs, lending and abolition of taxation. Therefore, the advent of an electric vehicle in all major cities of the world is inevitable.

  15. Electron scattering with polarized targets at TESLA

    International Nuclear Information System (INIS)

    Anselmino, M.; Aschenauer, E.C.; Belostotski, S.

    2000-11-01

    Measurements of polarized electron-nucleon scattering can be realized at the TESLA linear collider facility with projected luminosities that are about two orders of magnitude higher than those expected of other experiments at comparable energies. Longitudinally polarized electrons, accelerated as a small fraction of the total current in the e + arm of TESLA, can be directed onto a solid state target that may be either longitudinally or transversely polarized. A large variety of polarized parton distribution and fragmentation functions can be determined with unprecedented accuracy, many of them for the first time. A main goal of the experiment is the precise measurement of the x- and Q 2 -dependence of the experimentally totally unknown quark transversity distributions that will complete the information on the nucleon's quark spin structure as relevant for high energy processes. Comparing their Q 2 -evolution to that of the corresponding helicity distributions constitutes an important precision test of the predictive power of QCD in the spin sector. Measuring transversity distributions and tensor charges allows access to the hitherto unmeasured chirally odd operators in QCD which are of great importance to understand the role of chiral symmetry. The possibilities of using unpolarized targets and of experiments with a real photon beam turn TESLA-N into a versatile next-generation facility at the intersection of particle and nuclear physics. (orig.)

  16. Evaluation of microbial transformations of dissolved organic matter - what information can be extracted from high-field FTICR-MS elemental formula data sets?

    Science.gov (United States)

    Herzsprung, Peter; von Tümpling, Wolf; Harir, Mourad; Hertkorn, Norbert; Schmitt-Kopplin, Philippe; Norf, Helge; Weitere, Markus; Kamjunke, Norbert

    2017-04-01

    Transformation of DOC and DOM was and is widespread investigated (1-3). Due to the complex composition of DOC increased attention was payed to DOM quality change during degradation processes. In order to get a better insight in DOM transformation processes both resolution as a function of time and on a molecular level are promising. The observation of DOM quality changes requires sophisticated evaluation techniques. A new evaluation strategy of FTICR-MS elemental formula data sets is introduced. An experiment with seven flumes and leaf leachate was performed. All flumes were sampled on five dates (within 7 days) and the SPEDOM was characterized using high-field FTICR-MS analysis, resulting in together 35 elemental formula data sets. The time dependent change of components abundance was fitted by a simple linear regression model after normalization of mass peak intensities. All components were categorized by calculation of the slope (change of percent intensity per day) in all seven flumes. A positive slope means product formation, a negative slope means degradation of components. Specific data filtration was developed to find out components with relevant change of relative intensity. About 7000 different components were present in at least one of the 35 samples. Of those about 1800 components were present in all of the 35 samples. About 300 components with significant increase of intensity were identified. They were mainly unsaturated and oxygen-rich components (lignin-like or tannin-like) and had molecular masses less than 450 Dalton. A group of about 70 components was partially degraded (significant negative slope, present in all samples). These components were more saturated and less oxygen-rich compared to the product group and had molecular masses > 450 Dalton. A third group of about 150 components was identified with a tendency to total degradation (significant negative slope, not present in all samples, reduced or no abundance at the end of the experiment

  17. Small horizontal emittance in the TESLA damping ring

    International Nuclear Information System (INIS)

    Decking, W.

    2001-01-01

    The present TESLA damping ring is designed for a normalized horizontal emittance of 8x10 -6 m. γ-γ collisions at the TESLA linear collider will benefit from a further decrease of the horizontal emittance. This paper reviews the processes which limit the horizontal emittance in the damping ring. Preliminary estimates on the smallest horizontal emittance for the present TESLA damping ring design as well as an ultimate limit of the emittance reachable with the TESLA damping ring concept will be given

  18. MR appearances of intracranial tumors with a low tesla (0.064 T) permanent MR system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hee Jin; Lim, Sun Kyung; Kwon, Dae Ik; Kim, Byung Young; Lee, Jong Gil [Fatima Hospital, Taegu (Korea, Republic of)

    1993-09-15

    In this report we describe twenty-two cases of intracranial tumors studied with an MR imager operating at a field strength of 0.064 T for evaluation of the clinical utility of low tesla MRI. The confirmed diagnoses were meningioma(9 cases), astrocytoma(4 cases), glioblastoma multiforme (1 case), craniopharyngioma(2 cases), intracranial metastasis(1 cases), pituitary microadenomal(1 cases), hemangioblastoma(1 cases), and trigerminal neurilemmoma(1 cases). Meningiomas appeared as well-marginated, homogeneous signal intensity masses (67%) in most cases. Most meningiomas showed iso-signal intensity(78%) on T1-weighted images, and high signal intensity on T2-weighted images. After Gd-DTPA enhancement, diffuse homogeneous contrast enhancement(75%) was well seen. The mutiple hemorrhage foci within the glioblastoma multiforme were identified, which showed high signal intensity on T1-weighted images and low signal intensity on T2-weighted images(intracellular methemoglobin) or high signal intensity on both T1 and T2-weighted images(extracellular methemoglobin). One case of cerebellar hemangioblastoma was a well- defined cystic mass with contrast enhanced mural nodule but no identification of characteristic signal void vessels. The remaining tumors showed low signal intensity on T1-weighted images, and high signal intensity on T2-weighted images. Gd-DTPA enhancement was helpful in separating the lesion from the surrounding edema or normal tissue, but had limited diagnostic value in characterizing the nature of the mass. The advantage of low tesla MRI are as follows: on requirement of cooling water or electricity, open design, shorter T1 relaxation time compared with high tesla unit that increases the difference of T1-relaxation time between tissues, ease of installation, and cost effectiveness. In conclusion, The low tesla MRI is useful for the detection and evaluation of the brain tumors.

  19. MR appearances of intracranial tumors with a low tesla (0.064 T) permanent MR system

    International Nuclear Information System (INIS)

    Kim, Hee Jin; Lim, Sun Kyung; Kwon, Dae Ik; Kim, Byung Young; Lee, Jong Gil

    1993-01-01

    In this report we describe twenty-two cases of intracranial tumors studied with an MR imager operating at a field strength of 0.064 T for evaluation of the clinical utility of low tesla MRI. The confirmed diagnoses were meningioma(9 cases), astrocytoma(4 cases), glioblastoma multiforme (1 case), craniopharyngioma(2 cases), intracranial metastasis(1 cases), pituitary microadenomal(1 cases), hemangioblastoma(1 cases), and trigerminal neurilemmoma(1 cases). Meningiomas appeared as well-marginated, homogeneous signal intensity masses (67%) in most cases. Most meningiomas showed iso-signal intensity(78%) on T1-weighted images, and high signal intensity on T2-weighted images. After Gd-DTPA enhancement, diffuse homogeneous contrast enhancement(75%) was well seen. The mutiple hemorrhage foci within the glioblastoma multiforme were identified, which showed high signal intensity on T1-weighted images and low signal intensity on T2-weighted images(intracellular methemoglobin) or high signal intensity on both T1 and T2-weighted images(extracellular methemoglobin). One case of cerebellar hemangioblastoma was a well- defined cystic mass with contrast enhanced mural nodule but no identification of characteristic signal void vessels. The remaining tumors showed low signal intensity on T1-weighted images, and high signal intensity on T2-weighted images. Gd-DTPA enhancement was helpful in separating the lesion from the surrounding edema or normal tissue, but had limited diagnostic value in characterizing the nature of the mass. The advantage of low tesla MRI are as follows: on requirement of cooling water or electricity, open design, shorter T1 relaxation time compared with high tesla unit that increases the difference of T1-relaxation time between tissues, ease of installation, and cost effectiveness. In conclusion, The low tesla MRI is useful for the detection and evaluation of the brain tumors

  20. Spatial Segmentation of MALDI FT-ICR MSI Data: A Powerful Tool to Explore the Head and Neck Tumor In Situ Lipidome

    Czech Academy of Sciences Publication Activity Database

    Krásný, Lukáš; Hoffmann, F.; Ernst, G.; Trede, D.; Alexandrov, T.; Havlíček, Vladimír; Guntinas-Lichius, O.; von Eggeling, F.; Crecelius, A.C.

    2015-01-01

    Roč. 26, č. 1 (2015), s. 36-43 ISSN 1044-0305 R&D Projects: GA MŠk(CZ) LD13038 Institutional support: RVO:61388971 Keywords : MALDI * MSI * FT-ICR Subject RIV: CE - Biochemistry Impact factor: 3.031, year: 2015

  1. MRI of the carotid artery at 7 Tesla: Quantitative comparison with 3 Tesla

    NARCIS (Netherlands)

    Koning, Wouter; De Rotte, Alexandra A J; Bluemink, Johanna J.; Van Der Velden, Tijl A.; Luijten, Peter R.; Klomp, DWJ; Zwanenburg, Jaco J M

    2015-01-01

    Purpose: To evaluate the 7 Tesla (T) MRI of the carotid arteries, as quantitatively compared with 3T. Materials and Methods: The 7T MRI of the carotid arteries was performed in six healthy subjects and in two patients with carotid stenosis. The healthy group was scanned at 3T and at 7T, using

  2. A 4 Tesla/1 meter superferric MRI magnet

    International Nuclear Information System (INIS)

    Schmidt, W.M.; Huson, F.R.; Mackay, W.W.; Rocha, R.M.

    1991-01-01

    Superferric technology was first applied to Magnetic Resonance Imaging (MRI) magnets by the Texas Accelerator Center (TAC) in 1986 with the design and construction of a 4 Tesla/30 cm magnet. In an evolutionary step, this technology is now being applied to the development of a whole body 4 Tesla/1 meter superconducting magnet. The design of such a magnetis presented in this paper

  3. TeSLA pilot 2 pedagogical & quality aspects

    OpenAIRE

    Janssen, José

    2018-01-01

    Presentation given at the TeSLA project meeting at the Open University of the Netherlands, addressing pedagogical aspects of pilot 2 and clarification of the scope and limitations of the TeSLA instruments with respect to pedagogy, assessment activity and type of academic dishonesty.

  4. Jakob Narkiewicz-Jodko-Tesla ``Predecessor''

    Science.gov (United States)

    Samuilov, Vladimir; Kiselev, Vladimir

    2014-03-01

    Prof. Jakob Narkiewicz-Jodko (1947-1905) is a bright figure in the history of science of the XIXth century. His major discoveries are: Electrography - the method of the visualization of electric discharge from the bodies due to the application of high strength and high frequency electric fields, and one of the first observations of the propagation of the electromagnetic waives and information transfer over the distances. We review Prof. Jakob Narkiewicz-Jodko's research results and explain our point why we consider him as the predecessor of Nikola Tesla.

  5. Superconducting superstructure for the TESLA collider

    Energy Technology Data Exchange (ETDEWEB)

    Sekutowicz, J.; Tang, C. [DESY, MHF-SL, Hamburg (Germany); Ferrario, M. [INFN, Laboratori Nazionali di Frascati, Rome (Italy)

    1998-04-01

    The Authors discuss the new layout of a cavity chain (superstructure) allowing, the Authors hope, significant cost reduction of the RF system of both linacs of the TESLA linear collider. The proposed scheme increases the fill factor and thus makes an effective gradient of an accelerator higher. The authors present mainly computations that have performed up to now and which encouraged to order the copper model of the scheme, still keeping in mind that experiments with a beam will be necessary to prove if the proposed solution can be used for the acceleration.

  6. Nikola Tesla: the man behind the magnetic field unit.

    Science.gov (United States)

    Roguin, Ariel

    2004-03-01

    The magnetic field strength of both the magnet and gradient coils used in MR imaging equipment is measured in Tesla units, which are named for Nikola Tesla. This article presents the life and achievements of this Serbian-American inventor and researcher who discovered the rotating magnetic field, the basis of most alternating-current machinery. Nikola Tesla had 700 patents in the United States and Europe that covered every aspect of science and technology. Tesla's discoveries include the Tesla coil, AC electrical conduction, improved lighting, newer forms of turbine engines, robotics, fluorescent light, wireless transmission of electrical energy, radio, remote control, discovery of cosmic radio waves, and the use of the ionosphere for scientific purposes. He was a genius whose discoveries had a pivotal role in advancing us into the modern era. Copyright 2004 Wiley-Liss, Inc.

  7. Quantitative techniques for musculoskeletal MRI at 7 Tesla.

    Science.gov (United States)

    Bangerter, Neal K; Taylor, Meredith D; Tarbox, Grayson J; Palmer, Antony J; Park, Daniel J

    2016-12-01

    Whole-body 7 Tesla MRI scanners have been approved solely for research since they appeared on the market over 10 years ago, but may soon be approved for selected clinical neurological and musculoskeletal applications in both the EU and the United States. There has been considerable research work on musculoskeletal applications at 7 Tesla over the past decade, including techniques for ultra-high resolution morphological imaging, 3D T2 and T2* mapping, ultra-short TE applications, diffusion tensor imaging of cartilage, and several techniques for assessing proteoglycan content in cartilage. Most of this work has been done in the knee or other extremities, due to technical difficulties associated with scanning areas such as the hip and torso at 7 Tesla. In this manuscript, we first provide some technical context for 7 Tesla imaging, including challenges and potential advantages. We then review the major quantitative MRI techniques being applied to musculoskeletal applications on 7 Tesla whole-body systems.

  8. Mass

    International Nuclear Information System (INIS)

    Quigg, Chris

    2007-01-01

    In the classical physics we inherited from Isaac Newton, mass does not arise, it simply is. The mass of a classical object is the sum of the masses of its parts. Albert Einstein showed that the mass of a body is a measure of its energy content, inviting us to consider the origins of mass. The protons we accelerate at Fermilab are prime examples of Einsteinian matter: nearly all of their mass arises from stored energy. Missing mass led to the discovery of the noble gases, and a new form of missing mass leads us to the notion of dark matter. Starting with a brief guided tour of the meanings of mass, the colloquium will explore the multiple origins of mass. We will see how far we have come toward understanding mass, and survey the issues that guide our research today.

  9. Nikola Tesla - genije koji je premostio vekove

    Directory of Open Access Journals (Sweden)

    Vladimir T. Ristić

    2006-07-01

    Full Text Available Ispisujući prve stranice svoje obimne knjige o životnom putu Nikole Tesle, američki pisac Džon Oí Nil kaže: Tesla je bio mislilac i pronalazač najvišeg reda, onaj što mišljenjem, a ne slučajem, dolazi do otkrića, dok mu eksperiment služi samo za potvrdu njegove teze. On je bio i matematičar, znao je bezbroj formula napamet, tako da se najčešće nije morao služiti priručnicima; osim toga, imao je najsolidnije tehničko obrazovanje, što je, na primer, Edisonu nedostajalo. Nikola Tesla je osnovno školovanje započeo u rodnom Smiljanu, a nastavio i dovršio u Gospiću gde se sa roditeljima, posle smrti starijeg brata, preselio. Gimnaziju je upisao u Karlovcu. Bila je to ugledna škola, a u profesoru fizike Nikola je imao izuzetnog pedagoga, koji je svojim đacima umeo vrlo vešto da dočara čak i ono što je u fizici teško razumljivo.

  10. 76 FR 47639 - Tesla Motors, Inc.; Receipt of Petition for Temporary Exemption From the Electronic Stability...

    Science.gov (United States)

    2011-08-05

    ...-0110] Tesla Motors, Inc.; Receipt of Petition for Temporary Exemption From the Electronic Stability... accordance with the procedures in 49 CFR part 555, Tesla Motors, Inc., has petitioned the agency for a... part 555, Tesla Motors, Inc. (Tesla) submitted a petition dated June 7, 2001 asking the agency for a...

  11. 77 FR 22383 - Petition for Exemption From the Federal Motor Vehicle Motor Theft Prevention Standard; TESLA

    Science.gov (United States)

    2012-04-13

    ... From the Federal Motor Vehicle Motor Theft Prevention Standard; TESLA AGENCY: National Highway Traffic... exemption. SUMMARY: This document grants in full the petition of Tesla Motors Inc's. (Tesla) for an... 49 CFR Part 541, Federal Motor Vehicle Theft Prevention Standard. Tesla requested confidential...

  12. Tesla Coil Theoretical Model and its Experimental Verification

    OpenAIRE

    Voitkans Janis; Voitkans Arnis

    2014-01-01

    In this paper a theoretical model of Tesla coil operation is proposed. Tesla coil is described as a long line with distributed parameters in a single-wire form, where the line voltage is measured across electrically neutral space. By applying the principle of equivalence of single-wire and two-wire schemes an equivalent two-wire scheme can be found for a single-wire scheme and the already known long line theory can be applied to the Tesla coil. A new method of multiple re...

  13. A new interlock design for the TESLA RF system

    International Nuclear Information System (INIS)

    Leich, H.; Kahl, J.; Choroba, S.; Grevsmuehl, T.; Heidbrook, N.

    2001-01-01

    The RF system for TESLA requires a comprehensive interlock system. Usually interlock systems are organized in a hierarchical way. In order to react to different fault conditions in a fast and flexible manner a nonhierarchical organization seems to be the better solution. At the TESLA Test Facility (TTF) at DESY the authors will install a nonhierarchical interlock system that is based on user designed reprogrammable gate-arrays (FPGA's) which incorporate an embedded microcontroller system. This system could be used later for the TESLA linear collider replacing a strictly hierarchical design

  14. 12 tesla test coil. Annual progress report

    International Nuclear Information System (INIS)

    1979-01-01

    The Plasma Fusion Center at MIT has been charged with responsibility for the design, development, fabrication and test operation of a Niobium-3-Tin Superconducting Test Coil. Research is described on DOE's 12 tesla coil demonstration program in which several one-meter diameter superconducting test coils will be inserted and tested in DOE's High Field Test Facility at the Lawrence Livermore Laboratories. The work was initiated at the start of FY 79. FY 79 saw the completion of our Preliminary Design and the initiation of three (3) subcontracts: (1) Westinghouse review of the Preliminary Design, (II) Supercon, Inc. development of a tubular copper matrix, Nb 3 Sn Superconductor and (III) Airco optimization of the LCP-W Nb 3 Sn superconductor for 12T service. In addition, Airco was charged with the production of a 1000 foot length of model 15,000A conductor. Coil winding exercises were initiated at the Everson Electric Company

  15. Instrumentation of the forward region of the TESLA detector

    International Nuclear Information System (INIS)

    Buesser, Karsten

    2004-01-01

    The expected beam-beam interaction at the proposed TESLA electron-positron linear collider has a significant impact on the design of the TESLA detector. Especially the instrumentation of the very forward region down to polar angles below 5 mrad will have to handle an immense background of electrons and positrons adding up to TeVs of energy deposition per bunch crossing. Instrumentation down to small angles is crucial not only for the measurement of the luminosity through Bhabha scattering, but also to maximize the hermeticity of the detector. Additionally these charged particles from beamstrahlung have to be measured as part of the feedback system of the TESLA accelerator and could also be used for beam diagnostics. The present design of the TESLA detector foresees two calorimeters in the forward region whose technologies have to meet the requirements regarding detector resolutions and radiation hardness. (orig.)

  16. Cascading Tesla Oscillating Flow Diode for Stirling Engine Gas Bearings

    Science.gov (United States)

    Dyson, Rodger

    2012-01-01

    Replacing the mechanical check-valve in a Stirling engine with a micromachined, non-moving-part flow diode eliminates moving parts and reduces the risk of microparticle clogging. At very small scales, helium gas has sufficient mass momentum that it can act as a flow controller in a similar way as a transistor can redirect electrical signals with a smaller bias signal. The innovation here forces helium gas to flow in predominantly one direction by offering a clear, straight-path microchannel in one direction of flow, but then through a sophisticated geometry, the reversed flow is forced through a tortuous path. This redirection is achieved by using microfluid channel flow to force the much larger main flow into this tortuous path. While microdiodes have been developed in the past, this innovation cascades Tesla diodes to create a much higher pressure in the gas bearing supply plenum. In addition, the special shape of the leaves captures loose particles that would otherwise clog the microchannel of the gas bearing pads.

  17. Radiation protection systems on the TESLA Accelerator Installation

    International Nuclear Information System (INIS)

    Pavlovic, R.

    1996-01-01

    In the Institute of Nuclear sciences VINCA, the Accelerator Installation TESLA which is an medium energy ion accelerator facility consisting of an isochronous cyclotron VINCY, a heavy ion source, a D/H ion source, three low energy and five high energy experimental channels is now under construction. Some problems in defining radiation protection and safety programme, particularly problems in construction appropriate shielding barriers at the Accelerator Installation TESLA are discussed in this paper. (author

  18. Superconducting magnet package for the TESLA test facility

    International Nuclear Information System (INIS)

    Koski, A.; Bandelmann, R.; Wolff, S.

    1996-01-01

    The magnetic lattice of the TeV electron superconducting linear accelerator (TESLA) will consist of superconducting quadrupoles for beam focusing and superconducting correction dipoles for beam steering, incorporated in the cryostats containing the superconducting cavities. This report describes the design of these magnets, presenting details of the magnetic as well as the mechanical design. The measured characteristics of the TESLA Test Facility (TTF) quadrupoles and dipoles are compared to the results obtained from numerical computations

  19. Tesla the life and times of an electric messiah

    CERN Document Server

    Cawthorne, Nigel

    2014-01-01

    Despite being incredibly popular during his time, Nikola Tesla today remains largely overlooked among lists of the greatest inventors and scientists of the modern era.  Thomas Edison gets all the glory for discovering the light bulb, but it was his one time assistant and life long arch nemesis, Tesla, who made the breakthrough in alternating current technology.  Edison and Tesla carried on a bitter feud for years, but it was Tesla's AC generators that illuminated the 1893 World's Fair in Chicago; the first time that an event of such magnitude had ever taken place under artificial light.  Today, all homes and electrical appliances run on Tesla's AC current.Born in Croatia in 1856, Tesla spoke eight languages and as well as almost single handedly developing household electricity.  During his life, he patented more than 700 inventions.  He invented electrical generators, FM radio, remote control robots, spark plugs and fluorescent lights.  He had a photographic memory and did advanced calculus and physic...

  20. Tesla Coil Theoretical Model and its Experimental Verification

    Directory of Open Access Journals (Sweden)

    Voitkans Janis

    2014-12-01

    Full Text Available In this paper a theoretical model of Tesla coil operation is proposed. Tesla coil is described as a long line with distributed parameters in a single-wire form, where the line voltage is measured across electrically neutral space. By applying the principle of equivalence of single-wire and two-wire schemes an equivalent two-wire scheme can be found for a single-wire scheme and the already known long line theory can be applied to the Tesla coil. A new method of multiple reflections is developed to characterize a signal in a long line. Formulas for calculation of voltage in Tesla coil by coordinate and calculation of resonance frequencies are proposed. The theoretical calculations are verified experimentally. Resonance frequencies of Tesla coil are measured and voltage standing wave characteristics are obtained for different output capacities in the single-wire mode. Wave resistance and phase coefficient of Tesla coil is obtained. Experimental measurements show good compliance with the proposed theory. The formulas obtained in this paper are also usable for a regular two-wire long line with distributed parameters.

  1. Proposed applications with implementation techniques of the upcoming renewable energy resource, The Tesla Turbine

    International Nuclear Information System (INIS)

    Khan, M Usman Saeed; Maqsood, M Irfan; Ali, Ehsan; Jamal, Shah; Javed, M

    2013-01-01

    Recent research has shown that tesla turbine can be one of the future efficient sources of renewable energy. Modern techniques used for designing of tesla turbine have given optimum results regarding efficiency and applications. In this paper we have suggested fully coordinated applications of tesla turbine in different fields particularly in power generation at both low level and high level generation. In Energy deficient countries the tesla turbine has wide range of applications and it can play an important role in energy management system. Our proposed applications includes, - the use of tesla turbine as renewable energy resource; - using tesla turbine in distributed generation system; - use of tesla turbine at home for power generation; - use of tesla turbine in irrigation channels; - using tesla turbine in hybrid electric vehicles; All applications are explained with the help of flow charts and block diagrams and their implementation techniques are also explained in details. The results of physical experiments and simulations are also included for some applications.

  2. Radiation safety and radiation protection problems on the TESLA Accelerator Installation

    International Nuclear Information System (INIS)

    Pavlovic, R.; Pavlovic, S.; Orlic, M.

    1997-01-01

    As we can see from the examples of many accelerator facilities installed throughout the world with ion beam energy, mass and charge characteristics and design similar to the TESLA Accelerator Installation, there is a great diversity among them, and each radiation protection and safety programme must be designed to facilitate the safe and effective operation of the accelerator according to the needs of the operating installation. Although there is no standard radiation protection and safety organization suitable for all institutions, experience suggests some general principles that should be integrated with all the disciplines involved in a comprehensive safety programme. (author)

  3. Structural elucidation of fucosylated chondroitin sulfates from sea cucumber using FTICR-MS/MS.

    Science.gov (United States)

    Agyekum, Isaac; Pepi, Lauren; Yu, Yanlei; Li, Junhui; Yan, Lufeng; Linhardt, Robert J; Chen, Shiguo; Amster, I Jonathan

    2018-02-01

    Fucosylated chondroitin sulfates are complex polysaccharides extracted from sea cucumber. They have been extensively studied for their anticoagulant properties and have been implicated in other biological activities. While nuclear magnetic resonance spectroscopy has been used to extensively characterize fucosylated chondroitin sulfate oligomers, we herein report the first detailed mass characterization of fucosylated chondroitin sulfate using high-resolution Fourier transform ion cyclotron resonance mass spectrometry. The two species of fucosylated chondroitin sulfates considered for this work include Pearsonothuria graeffei (FCS-Pg) and Isostichopus badionotus (FCS-Ib). Fucosylated chondroitin sulfate oligosaccharides were prepared by N-deacetylation-deaminative cleavage of the two fucosylated chondroitin sulfates and purified by repeated gel filtration. Accurate mass measurements obtained from electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry measurements confirmed the oligomeric nature of these two fucosylated chondroitin sulfate oligosaccharides with each trisaccharide repeating unit averaging four sulfates per trisaccharide. Collision-induced dissociation of efficiently deprotonated molecular ions through Na/H + exchange proved useful in providing structurally relevant glycosidic and cross-ring product ions, capable of assigning the sulfate modifications on the fucosylated chondroitin sulfate oligomers. Careful examination of the tandem mass spectrometry of both species deferring in the positions of sulfate groups on the fucose residue (FCS-Pg-3,4- OS) and (FCS-Ib-2,4- OS) revealed cross-ring products 0,2 A αf and 2,4 X 2αf which were diagnostic for (FCS-Pg-3,4- OS) and 0,2 X 2αf diagnostic for (FCS-Ib-2,4- OS). Mass spectrometry and tandem mass spectrometry data acquired for both species varying in oligomer length (dp3-dp15) are presented.

  4. How Much Tesla Is Too Much?

    International Nuclear Information System (INIS)

    Monu, U.V.J.

    2015-01-01

    There are 7 Tesla (T) scanners operate in up to 35 research clinics worldwide. Currently 11T, 9T, 7T and 4T MRI in research facilities all over the world. The more powerful the magnet -the better the images, the faster the imaging time and the more patient put through. 10 -12 T seem to be the upper limit for current technology. The FDA has limited the power of the MRI for clinical use to 8T. Higher Field MRI Scanner-Advantages include Higher Field MRI Scanner, higher contrast to noise, higher spatial resolution and Images can be acquired at faster times. UltraHigh Field Imaging Advantageous in Sports medicine type patients with injury to tendons, ligaments and cartilage. Disadvantages of telsa to Safety Issues include Specific Absorption Rate (SARs) issues, Increased heating of tissues, Becomes an issue when imaging large structures, not a real problem in MSK except for spine imaging and Most units will adjust to approved parameters before scanning

  5. Solid targetry at the TESLA Accelerator Installation

    CERN Document Server

    Comor, J J; Rajcevic, M; Kosutic, D; Spasic, M; Vidovic, A; Duricic, J; Nedeljkovic, N

    2002-01-01

    According to the concept of the TESLA Accelerator Installation, the channel for production of radioisotopes has to routinely produce sup 2 sup 0 sup 1 Tl, sup 1 sup 1 sup 1 In, sup 6 sup 7 Ga, sup 1 sup 2 sup 3 I and sup 1 sup 8 F, and a number of other radionuclides for experimental purposes. The production of sup 1 sup 2 sup 3 I and sup 1 sup 8 F will be performed in dedicated, commercial target stations, while a versatile solid target irradiation system is designed for the routine and experimental production of all other radioisotopes. The solid target station is designed to accept targets for both the 7 deg. and 90 deg. irradiation geometry. The targets used for the routine production will be prepared by electroplating on a silver substrate. They can be irradiated with a 1.5 kW beam using the 7 deg. geometry. The cooling of these targets is enhanced by fins on the back of the silver substrate designed so that the highest temperature on the surface of the target does not exceed 110 deg. C. The irradiation ...

  6. [Studies of three-dimensional cardiac late gadolinium enhancement MRI at 3.0 Tesla].

    Science.gov (United States)

    Ishimoto, Takeshi; Ishihara, Masaru; Ikeda, Takayuki; Kawakami, Momoe

    2008-12-20

    Cardiac late Gadolinium enhancement MR imaging has been shown to allow assessment of myocardial viability in patients with ischemic heart disease. The current standard approach is a 3D inversion recovery sequence at 1.5 Tesla. The aims of this study were to evaluate the technique feasibility and clinical utility of MR viability imaging at 3.0 Tesla in patients with myocardial infarction and cardiomyopathy. In phantom and volunteer studies, the inversion time required to suppress the signal of interests and tissues was prolonged at 3.0 Tesla. In the clinical study, the average inversion time to suppress the signal of myocardium at 3.0 Tesla with respect to MR viability imaging at 1.5 Tesla was at 15 min after the administration of contrast agent (304.0+/-29.2 at 3.0 Tesla vs. 283.9+/-20.9 at 1.5 Tesla). The contrast between infarction and viable myocardium was equal at both field strengths (4.06+/-1.30 at 3.0 Tesla vs. 4.42+/-1.85 at 1.5 Tesla). Even at this early stage, MR viability imaging at 3.0 Tesla provides high quality images in patients with myocardial infarction. The inversion time is significantly prolonged at 3.0 Tesla. The contrast between infarction and viable myocardium at 3.0 Tesla are equal to 1.5 Tesla. Further investigation is needed for this technical improvement, for clinical evaluation, and for limitations.

  7. Utilization of high-accuracy FTICR-MS data in protein quantitation experiments

    Czech Academy of Sciences Publication Activity Database

    Strohalm, Martin; Novák, Petr; Pompach, Petr; Man, Petr; Kavan, Daniel; Witt, M.; Džubák, P.; Hajdúch, M.; Havlíček, Vladimír

    2009-01-01

    Roč. 44, č. 11 (2009), s. 1565-1570 ISSN 1076-5174 R&D Projects: GA MŠk LC07017 Institutional research plan: CEZ:AV0Z50200510 Keywords : mass spectrometry * protein quantitation * workflow Subject RIV: EE - Microbiology, Virology Impact factor: 3.411, year: 2009

  8. Report on the TESLA Engineering Study/Review

    Energy Technology Data Exchange (ETDEWEB)

    Cornuelle, John C.

    2002-08-30

    In March, 2001, the TESLA Collaboration published its Technical Design Report (TDR, see references and links in Appendix), the first sentence of which stated ''...TESLA (TeV-Energy Superconducting Linear Collider) (will be) a superconducting electron-positron collider of initially 500 GeV total energy, extendable to 800 GeV, and an integrated X-ray laser laboratory.'' The TDR included cost and manpower estimates for a 500 GeV e{sup +}e{sup -} collider (250 on 250 GeV) based on superconducting RF cavity technology. This was submitted as a proposal to the German government. The government asked the German Science Council to evaluate this proposal. The recommendation from this body is anticipated to be available by November 2002. The government has indicated that it will react on this recommendation by mid-2003. In June 2001, Steve Holmes, Fermilab's Associate Director for Accelerators, commissioned Helen Edwards and Peter Garbincius to organize a study of the TESLA Technical Design Report and the associated cost and manpower estimates. Since the elements and methodology used in producing the TESLA cost estimate were somewhat different from those used in preparing similar estimates for projects within the U.S., it is important to understand the similarities, differences, and equivalences between the TESLA estimate and U.S. cost estimates. In particular, the project cost estimate includes only purchased equipment, materials, and services, but not manpower from DESY or other TESLA collaborating institutions, which is listed separately. It does not include the R&D on the TESLA Test Facility (TTF) nor the costs of preparing the TDR nor the costs of performing the conceptual studies so far. The manpower for the pre-operations commissioning program (up to beam) is included in the estimate, but not the electrical power or liquid Nitrogen (for initial cooldown of the cryogenics plant). There is no inclusion of any contingency or management reserve. If

  9. Report on the TESLA Engineering Study/Review

    International Nuclear Information System (INIS)

    Cornuelle, John C.

    2002-01-01

    In March, 2001, the TESLA Collaboration published its Technical Design Report (TDR, see references and links in Appendix), the first sentence of which stated ''...TESLA (TeV-Energy Superconducting Linear Collider) (will be) a superconducting electron-positron collider of initially 500 GeV total energy, extendable to 800 GeV, and an integrated X-ray laser laboratory.'' The TDR included cost and manpower estimates for a 500 GeV e + e - collider (250 on 250 GeV) based on superconducting RF cavity technology. This was submitted as a proposal to the German government. The government asked the German Science Council to evaluate this proposal. The recommendation from this body is anticipated to be available by November 2002. The government has indicated that it will react on this recommendation by mid-2003. In June 2001, Steve Holmes, Fermilab's Associate Director for Accelerators, commissioned Helen Edwards and Peter Garbincius to organize a study of the TESLA Technical Design Report and the associated cost and manpower estimates. Since the elements and methodology used in producing the TESLA cost estimate were somewhat different from those used in preparing similar estimates for projects within the U.S., it is important to understand the similarities, differences, and equivalences between the TESLA estimate and U.S. cost estimates. In particular, the project cost estimate includes only purchased equipment, materials, and services, but not manpower from DESY or other TESLA collaborating institutions, which is listed separately. It does not include the R and D on the TESLA Test Facility (TTF) nor the costs of preparing the TDR nor the costs of performing the conceptual studies so far. The manpower for the pre-operations commissioning program (up to beam) is included in the estimate, but not the electrical power or liquid Nitrogen (for initial cooldown of the cryogenics plant). There is no inclusion of any contingency or management reserve. If the U.S. were to become

  10. Online quench-flow electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for elucidating kinetic and chemical enzymatic reaction mechanisms.

    Science.gov (United States)

    Clarke, David J; Stokes, Adam A; Langridge-Smith, Pat; Mackay, C Logan

    2010-03-01

    We have developed an automated quench-flow microreactor which interfaces directly to an electrospray ionization (ESI) mass spectrometer. We have used this device in conjunction with ESI Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) to demonstrate the potential of this approach for studying the mechanistic details of enzyme reactions. For the model system chosen to test this device, namely, the pre-steady-state hydrolysis of p-nitrophenyl acetate by the enzyme chymotrypsin, the kinetic parameters obtained are in good agreement with those in the literature. To our knowledge, this is the first reported use of online quench-flow coupled with FTICR MS. Furthermore, we have exploited the power of FTICR MS to interrogate the quenched covalently bound enzyme intermediate using top-down fragmentation. The accurate mass capabilities of FTICR MS permitted the nature of the intermediate to be assigned with high confidence. Electron capture dissociation (ECD) fragmentation allowed us to locate the intermediate to a five amino acid section of the protein--which includes the known catalytic residue, Ser(195). This experimental approach, which uniquely can provide both kinetic and chemical details of enzyme mechanisms, is a potentially powerful tool for studies of enzyme catalysis.

  11. Reproducibility of small animal cine and scar cardiac magnetic resonance imaging using a clinical 3.0 tesla system

    International Nuclear Information System (INIS)

    Manka, Robert; Jahnke, Cosima; Hucko, Thomas; Dietrich, Thore; Gebker, Rolf; Schnackenburg, Bernhard; Graf, Kristof; Paetsch, Ingo

    2013-01-01

    To evaluate the inter-study, inter-reader and intra-reader reproducibility of cardiac cine and scar imaging in rats using a clinical 3.0 Tesla magnetic resonance (MR) system. Thirty-three adult rats (Sprague–Dawley) were imaged 24 hours after surgical occlusion of the left anterior descending coronary artery using a 3.0 Tesla clinical MR scanner (Philips Healthcare, Best, The Netherlands) equipped with a dedicated 70 mm solenoid receive-only coil. Left-ventricular (LV) volumes, mass, ejection fraction and amount of myocardial scar tissue were measured. Intra-and inter-observer reproducibility was assessed in all animals. In addition, repeat MR exams were performed in 6 randomly chosen rats within 24 hours to assess inter-study reproducibility. The MR imaging protocol was successfully completed in 32 (97%) animals. Bland-Altman analysis demonstrated high intra-reader reproducibility (mean bias%: LV end-diastolic volume (LVEDV), -1.7%; LV end-systolic volume (LVESV), -2.2%; LV ejection fraction (LVEF), 1.0%; LV mass, -2.7%; and scar mass, -1.2%) and high inter-reader reproducibility (mean bias%: LVEDV, 3.3%; LVESV, 6.2%; LVEF, -4.8%; LV mass, -1.9%; and scar mass, -1.8%). In addition, a high inter-study reproducibility was found (mean bias%: LVEDV, 0.1%; LVESV, -1.8%; LVEF, 1.0%; LV mass, -4.6%; and scar mass, -6.2%). Cardiac MR imaging of rats yielded highly reproducible measurements of cardiac volumes/function and myocardial infarct size on a clinical 3.0 Tesla MR scanner system. Consequently, more widely available high field clinical MR scanners can be employed for small animal imaging of the heart e.g. when aiming at serial assessments during therapeutic intervention studies

  12. Calculation of secondary capacitance of compact Tesla pulse transformer

    International Nuclear Information System (INIS)

    Yu Binxiong; Liu Jinliang

    2013-01-01

    An analytic expression of the secondary capacitance of a compact Tesla pulse transformer is derived. Calculated result by the expression shows that two parts contribute to the secondary capacitance, namely the capacitance between inner and outer magnetic cores and the attached capacitance caused by the secondary winding. The attached capacitance equals to the capacitance of a coaxial line which is as long as the secondary coil, and whose outer and inner diameters are as large as the inner diameter of the outer magnetic and the outer diameter of the inner magnetic core respectively. A circuital model for analyzing compact Tesla transformer is built, and numeric calculation shows that the expression of the secondary capacitance is correct. Besides, a small compact Tesla transformer is developed, and related test is carried out. Test result confirms the calculated results by the expression derived. (authors)

  13. Operating experience with superconducting cavities at the TESLA test facility

    International Nuclear Information System (INIS)

    Moeller, Wolf-Dietrich

    2003-01-01

    A description of the TESLA Test Facility, which has been set up at DESY by the TeV Energy Superconducting Accelerator (TESLA) collaboration, will be given as it is now after five years of installation and operation. The experience with the first three modules, each containing 8 superconducting 9-cell cavities, installed and operated in the TTF-linac will be described. The measurements in the vertical and horizontal cryostats as well as in the modules will be compared. Recent results of the operation at the TESLA design current, macropulses of 800 μsec with bunches of 3.2 nC at a rate of 2.25 MHz are given. New measurement results of the higher order modes (HOM) will be presented. The operation and optimisation of the TTF Free Electron Laser (TTF-FEL) will also be covered in this paper. (author)

  14. Optic Nerve Assessment Using 7-Tesla Magnetic Resonance Imaging.

    Science.gov (United States)

    Singh, Arun D; Platt, Sean M; Lystad, Lisa; Lowe, Mark; Oh, Sehong; Jones, Stephen E; Alzahrani, Yahya; Plesec, Thomas

    2016-04-01

    The purpose of this study was to correlate high-resolution magnetic resonance imaging (MRI) and histologic findings in a case of juxtapapillary choroidal melanoma with clinical evidence of optic nerve invasion. With institutional review board approval, an enucleated globe with choroidal melanoma and optic nerve invasion was imaged using a 7-tesla MRI followed by histopathologic evaluation. Optical coherence tomography, B-scan ultrasonography, and 1.5-tesla MRI of the orbit (1-mm sections) could not detect optic disc invasion. Ex vivo, 7-tesla MRI detected optic nerve invasion, which correlated with histopathologic features. Our case demonstrates the potential to document the existence of optic nerve invasion in the presence of an intraocular tumor, a feature that has a major bearing on decision making, particularly for consideration of enucleation.

  15. Cortical microinfarcts detected in vivo on 3 tesla MRI : Clinical and radiological correlates

    NARCIS (Netherlands)

    Van Dalen, Jan Willem; Scuric, Eva E M; Van Veluw, Susanne J.; Caan, Matthan W A; Nederveen, Aart J.; Biessels, Geert Jan; Van Gool, Willem A.; Richard, Edo

    2015-01-01

    Background and Purpose-Cortical microinfarcts (CMIs) are a common postmortem finding associated with vascular risk factors, cognitive decline, and dementia. Recently, CMIs identified in vivo on 7 Tesla MRI also proved retraceable on 3 Tesla MRI. Methods-We evaluated CMIs on 3 Tesla MRI in a

  16. Cortical microinfarcts detected in vivo on 3 Tesla MRI: clinical and radiological correlates

    NARCIS (Netherlands)

    Dalen, J.W. van; Scuric, E.E.; Veluw, S.J. van; Caan, M.W.; Nederveen, A.J.; Biessels, G.J.; Gool, W.A. van; Richard, E.

    2015-01-01

    BACKGROUND AND PURPOSE: Cortical microinfarcts (CMIs) are a common postmortem finding associated with vascular risk factors, cognitive decline, and dementia. Recently, CMIs identified in vivo on 7 Tesla MRI also proved retraceable on 3 Tesla MRI. METHODS: We evaluated CMIs on 3 Tesla MRI in a

  17. Undulator systems for the TESLA X-FEL

    International Nuclear Information System (INIS)

    Pflueger, J.; Tischer, M.

    2002-01-01

    A large X-ray FEL lab is under consideration within the TESLA project and is supposed to be operated in parallel with the TESLA linear collider. There will be five SASE FELs and five conventional spontaneous undulators. A conceptual design study has been made for the undulator systems for these X-FELs. It includes segmentation into 6.1 m long undulator 'cells'. Each consists of a 5 m long undulator 'segment', a separate quadrupole, one horizontal and one vertical corrector, and a phase shifter. These items are presented and discussed

  18. Paul Drude's prediction of nonreciprocal mutual inductance for Tesla transformers.

    Science.gov (United States)

    McGuyer, Bart

    2014-01-01

    Inductors, transmission lines, and Tesla transformers have been modeled with lumped-element equivalent circuits for over a century. In a well-known paper from 1904, Paul Drude predicts that the mutual inductance for an unloaded Tesla transformer should be nonreciprocal. This historical curiosity is mostly forgotten today, perhaps because it appears incorrect. However, Drude's prediction is shown to be correct for the conditions treated, demonstrating the importance of constraints in deriving equivalent circuits for distributed systems. The predicted nonreciprocity is not fundamental, but instead is an artifact of the misrepresentation of energy by an equivalent circuit. The application to modern equivalent circuits is discussed.

  19. Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry

    NARCIS (Netherlands)

    Kong, H.; Wang, M.; Venema, K.; Maathuis, A.; Heijden, R. van der; Greef, J. van der; Xu, G.; Hankemeier, T.

    2009-01-01

    A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by

  20. T2 relaxation time in patellar cartilage - global and regional reproducibility at 1.5 Tesla and 3 Tesla

    International Nuclear Information System (INIS)

    Glaser, C.; Horng, A.; Mendlik, T.; Weckbach, S.; Hoffmann, R.T.; Wagner, S.; Raya, J.G.; Reiser, M.; Horger, W.

    2007-01-01

    Purpose: Evaluation of the global and regional reproducibility of T2 relaxation time in patellar cartilage at 1.5 T and 3 T. Materials and Methods: 6 left patellae of 6 healthy volunteers (aged 25-30, 3 female, 3 male) were examined using a fat-saturated multiecho sequence and a T1-w 3D-FLASH sequence with water excitation at 1.5 Tesla and 3 Tesla. Three consecutive data sets were acquired within one MRI session with the examined knee being repositioned in the coil and scanner between each data set. The segmented cartilage (FLASH sequence) was overlaid on the multiecho data and T2 values were calculated for the total cartilage, 3 horizontal layers consisting of a superficial, intermedial and deep layer, 3 facets consisting of a medial, median (ridge) and lateral facet (global T2 values) and 27 ROIs/MRI slices (regional T2 value). The reproducibility (precision error) was calculated as the root mean square average of the individual standard deviations [ms] and coefficients of variation (COV) [%]. Results: The mean global reproducibility error for T2 was 3.53% (±0.38%) at 1.5 Tesla and 3.25% (±0.61%) at 3 Tesla. The mean regional reproducibility error for T2 was 8.62% (±2.61%) at 1.5 Tesla and 9.66% (±3.37%) at 3 Tesla. There was no significant difference with respect to absolute reproducibility errors between 1.5 Tesla and 3 Tesla at a constant spatial resolution. However, different reproducibility errors were found between the cartilage layers. One third of the data variability could be attributed to the influence of the different cartilage layers, and another 10% to the influence of the separate MRI slices. Conclusion: Our data provides an estimation of the global and regional reproducibility errors of T2 in healthy cartilage. In the analysis of small subregions, an increase in the regional reproducibility error must be accepted. The data may serve as a basis for sample size calculations of study populations and may contribute to the decision regarding the

  1. 76 FR 60118 - Tesla Motors, Inc. Grant of Petition for Renewal of a Temporary Exemption From the Advanced Air...

    Science.gov (United States)

    2011-09-28

    ...-0070] Tesla Motors, Inc. Grant of Petition for Renewal of a Temporary Exemption From the Advanced Air... Protection. SUMMARY: This notice grants the petition of Tesla Motors, Inc. (Tesla) for the renewal of a... the one for Tesla. Over time, the number of petitions for exemption from the advanced air bag...

  2. 77 FR 2269 - Foreign-Trade Zone 18-San Jose, CA, Application for Subzone, Tesla Motors, Inc. (Electric...

    Science.gov (United States)

    2012-01-17

    ..., CA, Application for Subzone, Tesla Motors, Inc. (Electric Passenger Vehicles), Palo Alto and Fremont... passenger- vehicle manufacturing facilities of Tesla Motors, Inc. (Tesla), located in Palo Alto and Fremont... January 10, 2012. The Tesla facilities (currently employing over 1,000 workers) consist of two sites: Site...

  3. Tesla-VUPJT instruments suitable for application in water management

    International Nuclear Information System (INIS)

    Novakova, O.; Broj, K.; Fronka, O.; Kula, J.; Slezak, V.

    1987-01-01

    A comparison is made of new instruments by Tesla, Czechoslovakia, viz. the NA 6201 for low alpha and beta counting and the NRR 610 alpha-beta automatic gauge, with similar foreign made instruments. The factors are discussed which affect the overall detection efficiency and the background level. (B.S.). 4 tabs

  4. Upgrading the power supplies of TEXTOR for three Tesla operation

    International Nuclear Information System (INIS)

    Giesen, B.; Veiders, E.; Petree, F.; Fink, R.; Wagnitz, R.

    1986-01-01

    The toroidal magnetic system of TEXTOR can tolerate a magnetic field load of up to 2.6 Tesla routinely at full plasma current, and of up to 3 Tesla under certain boundary conditions and for a restricted number of discharges. The original power supply which can generate a toroidal magnetic field of 2 Tesla has been upgraded to operate at a field strength of 3 Tesla, by adding a new, controlled rectifier, with its own independent control, connected in parallel with the first. Studies were undertaken to determine its behaviour where control is lost, such as when a circuit breaker trips or in ''freewheel'' operation. This paper analyzes this asymmetrical arrangement and discusses the danger of damaging the smaller unit by commutating a large current into it. Moreover, in order to improve the availability of TEXTOR, the new controlled rectifier is redundant to two other units that control the vertical field and the ohmic heating coil currents. For this purpose the two bridges of this 12-pulse system are to be changed from a parallel to a series connexion, the free-wheeling diodes are disconnected and redeployed to block the large voltage pulses that are induced at plasma initiation, and 3-phase ''freewheeling'' thyristors are added that serve to reduce reactive power consumption

  5. Excerpts from Prodigal Genius: The Life of Nikola Tesla

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 3. Excerpts from Prodigal Genius: The Life of Nikola Tesla. John J O Neill. Classics Volume 12 Issue 3 March 2007 pp 91-96. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/012/03/0091-0096 ...

  6. Tesla coil discharges guided by femtosecond laser filaments in air

    Science.gov (United States)

    Brelet, Yohann; Houard, Aurélien; Arantchouk, Leonid; Forestier, Benjamin; Liu, Yi; Prade, Bernard; Carbonnel, Jérôme; André, Yves-Bernard; Mysyrowicz, André

    2012-04-01

    A Tesla coil generator was designed to produce high voltage pulses oscillating at 100 kHz synchronisable with a nanosecond temporal jitter. Using this compact high voltage generator, we demonstrate reproducible meter long discharges in air at a repetition rate of 1 Hz. Triggering and guiding of the discharges are performed in air by femtosecond laser filaments.

  7. Large-Signal Code TESLA: Current Status and Recent Development

    National Research Council Canada - National Science Library

    Chernyavskiy, Igor A; Vlasov, Alexander N; Cooke, Simon J; Abe, David K; Levush, Baruch; Antonsen, Jr., Thomas M; Nguyen, Khanh T

    2008-01-01

    .... One such tool is the large-signal code TESLA, which was successfully applied for the modeling of single-beam and multiple-beam klystron devices at the Naval Research Laboratory and which is now used by number of U.S. companies...

  8. TeSLA presentatie voor medewerkers van AMN

    NARCIS (Netherlands)

    Janssen, José

    2017-01-01

    Presentatie over Online toetsen voor medewerkers van AMN (www.amn.nl). Topics: assessment onderzoek Welten-instituut en meer in het bijzonder het TeSLA project waarin instrumenten voor authenticatie en auteurschap verificatie worden gecombineerd om betrouwbaar toetsen op afstand mogelijk te maken.

  9. Artefacts induced by coiled intracranial aneurysms on 3.0-Tesla versus 1.5-Tesla MR angiography—An in vivo and in vitro study

    Energy Technology Data Exchange (ETDEWEB)

    Schaafsma, Joanna D., E-mail: j.d.schaafsma@umcutrecht.nl [Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, PO Box 85500, 3508 GA Utrecht (Netherlands); Velthuis, Birgitta K., E-mail: b.k.velthuis@umcutrecht.nl [Imaging Division, University Medical Centre, PO Box 85500, 3508 GA Utrecht (Netherlands); Vincken, Koen L., E-mail: koen@isi.uu.nl [Image Sciences Institute, University Medical Centre, PO Box 85500, 3508 GA Utrecht (Netherlands); Kort, Gerard A.P. de, E-mail: g.a.p.dekort@umcutrecht.nl [Imaging Division, University Medical Centre, PO Box 85500, 3508 GA Utrecht (Netherlands); Rinkel, Gabriel J.E., E-mail: g.j.e.rinkel@umcutrecht.nl [Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, PO Box 85500, 3508 GA Utrecht (Netherlands); Bartels, Lambertus W., E-mail: w.bartels@umcutrecht.nl [Image Sciences Institute, University Medical Centre, PO Box 85500, 3508 GA Utrecht (Netherlands)

    2014-05-15

    Objective: To compare metal-induced artefacts from coiled intracranial aneurysms on 3.0-Tesla and 1.5-Tesla magnetic resonance angiography (MRA), since concerns persist on artefact enlargement at 3.0 Tesla. Materials and methods: We scanned 19 patients (mean age 53; 16 women) with 20 saccular aneurysms treated with coils only, at 1.5 and 3.0 Tesla according to standard clinical 3D TOF-MRA protocols containing a shorter echo-time but weaker read-out gradient at 3.0 Tesla in addition to intra-arterial digital subtraction angiography (IA-DSA). Per modality two neuro-radiologists assessed the occlusion status, measured residual flow, and indicated whether coil artefacts disturbed this assessment on MRA. We assessed relative risks for disturbance by coil artefacts, weighted kappa's for agreement on occlusion levels, and we compared remnant sizes. For artefact measurements, a coil model was created and scanned with the same protocols followed by 2D MR scans with variation of echo-time and read-out gradient strength. Results: Coil artefacts disturbed assessments less frequently at 3.0 Tesla than at 1.5 Tesla (RR: 0.3; 95%CI: 0.1–0.8). On 3.0-Tesla MRA, remnants were larger than on 1.5-Tesla MRA (difference: 0.7 mm; 95%CI: 0.3–1.1) and larger than on IA-DSA (difference: 1.0 mm; 95%CI: 0.6–1.5) with similar agreement on occlusion levels with IA-DSA for both field strengths (κ 0.53; 95%CI: 0.23–0.84 for 1.5-Tesla MRA and IA-DSA; κ 0.47; 95%CI: 0.19–0.76 for 3.0-Tesla MRA and IA-DSA). Coil model artefacts were smaller at 3.0 Tesla than at 1.5 Tesla. The echo-time influenced artefact size more than the read-out gradient. Conclusions: Artefacts were not larger, but smaller at 3.0 Tesla because a shorter echo-time at 3.0 Tesla negated artefact enlargement. Despite smaller artefacts and larger remnants at 3.0 Tesla, occlusion levels were similar for both field strengths.

  10. Artefacts induced by coiled intracranial aneurysms on 3.0-Tesla versus 1.5-Tesla MR angiography—An in vivo and in vitro study

    International Nuclear Information System (INIS)

    Schaafsma, Joanna D.; Velthuis, Birgitta K.; Vincken, Koen L.; Kort, Gerard A.P. de; Rinkel, Gabriel J.E.; Bartels, Lambertus W.

    2014-01-01

    Objective: To compare metal-induced artefacts from coiled intracranial aneurysms on 3.0-Tesla and 1.5-Tesla magnetic resonance angiography (MRA), since concerns persist on artefact enlargement at 3.0 Tesla. Materials and methods: We scanned 19 patients (mean age 53; 16 women) with 20 saccular aneurysms treated with coils only, at 1.5 and 3.0 Tesla according to standard clinical 3D TOF-MRA protocols containing a shorter echo-time but weaker read-out gradient at 3.0 Tesla in addition to intra-arterial digital subtraction angiography (IA-DSA). Per modality two neuro-radiologists assessed the occlusion status, measured residual flow, and indicated whether coil artefacts disturbed this assessment on MRA. We assessed relative risks for disturbance by coil artefacts, weighted kappa's for agreement on occlusion levels, and we compared remnant sizes. For artefact measurements, a coil model was created and scanned with the same protocols followed by 2D MR scans with variation of echo-time and read-out gradient strength. Results: Coil artefacts disturbed assessments less frequently at 3.0 Tesla than at 1.5 Tesla (RR: 0.3; 95%CI: 0.1–0.8). On 3.0-Tesla MRA, remnants were larger than on 1.5-Tesla MRA (difference: 0.7 mm; 95%CI: 0.3–1.1) and larger than on IA-DSA (difference: 1.0 mm; 95%CI: 0.6–1.5) with similar agreement on occlusion levels with IA-DSA for both field strengths (κ 0.53; 95%CI: 0.23–0.84 for 1.5-Tesla MRA and IA-DSA; κ 0.47; 95%CI: 0.19–0.76 for 3.0-Tesla MRA and IA-DSA). Coil model artefacts were smaller at 3.0 Tesla than at 1.5 Tesla. The echo-time influenced artefact size more than the read-out gradient. Conclusions: Artefacts were not larger, but smaller at 3.0 Tesla because a shorter echo-time at 3.0 Tesla negated artefact enlargement. Despite smaller artefacts and larger remnants at 3.0 Tesla, occlusion levels were similar for both field strengths

  11. Artefacts induced by coiled intracranial aneurysms on 3.0-Tesla versus 1.5-Tesla MR angiography--An in vivo and in vitro study.

    Science.gov (United States)

    Schaafsma, Joanna D; Velthuis, Birgitta K; Vincken, Koen L; de Kort, Gerard A P; Rinkel, Gabriel J E; Bartels, Lambertus W

    2014-05-01

    To compare metal-induced artefacts from coiled intracranial aneurysms on 3.0-Tesla and 1.5-Tesla magnetic resonance angiography (MRA), since concerns persist on artefact enlargement at 3.0Tesla. We scanned 19 patients (mean age 53; 16 women) with 20 saccular aneurysms treated with coils only, at 1.5 and 3.0Tesla according to standard clinical 3D TOF-MRA protocols containing a shorter echo-time but weaker read-out gradient at 3.0Tesla in addition to intra-arterial digital subtraction angiography (IA-DSA). Per modality two neuro-radiologists assessed the occlusion status, measured residual flow, and indicated whether coil artefacts disturbed this assessment on MRA. We assessed relative risks for disturbance by coil artefacts, weighted kappa's for agreement on occlusion levels, and we compared remnant sizes. For artefact measurements, a coil model was created and scanned with the same protocols followed by 2D MR scans with variation of echo-time and read-out gradient strength. Coil artefacts disturbed assessments less frequently at 3.0Tesla than at 1.5Tesla (RR: 0.3; 95%CI: 0.1-0.8). On 3.0-Tesla MRA, remnants were larger than on 1.5-Tesla MRA (difference: 0.7mm; 95%CI: 0.3-1.1) and larger than on IA-DSA (difference: 1.0mm; 95%CI: 0.6-1.5) with similar agreement on occlusion levels with IA-DSA for both field strengths (κ 0.53; 95%CI: 0.23-0.84 for 1.5-Tesla MRA and IA-DSA; κ 0.47; 95%CI: 0.19-0.76 for 3.0-Tesla MRA and IA-DSA). Coil model artefacts were smaller at 3.0Tesla than at 1.5Tesla. The echo-time influenced artefact size more than the read-out gradient. Artefacts were not larger, but smaller at 3.0Tesla because a shorter echo-time at 3.0Tesla negated artefact enlargement. Despite smaller artefacts and larger remnants at 3.0Tesla, occlusion levels were similar for both field strengths. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  12. Construction of 0.15 Tesla Overhauser Enhanced MRI.

    Science.gov (United States)

    Tokunaga, Yuumi; Nakao, Motonao; Naganuma, Tatsuya; Ichikawa, Kazuhiro

    2017-01-01

    Overhauser enhanced MRI (OMRI) is one of the free radical imaging technologies and has been used in biomedical research such as for partial oxygen measurements in tumor, and redox status in acute oxidative diseases. The external magnetic field of OMRI is frequently in the range of 5-10 mTesla to ensure microwave penetration into small animals, and the S/N ratio is limited. In this study, a 0.15 Tesla OMRI was constructed and tested to improve the S/N ratio for a small sample, or skin measurement. Specification of the main magnet was as follows: 0.15 Tesla permanent magnet; gap size 160 mm; homogenous spherical volume of 80 mm in diameter. The OMRI resonator was designed based on TE 101 cavity mode and machined from a phosphorus deoxidized copper block for electron spin resonance (ESR) excitation and a solenoid transmission/receive resonator for NMR detection. The resonant frequencies and Q values were 6.38 MHz/150 and 4.31-4.41 GHz/120 for NMR and ESR, respectively. The Q values were comparable to those of conventional low field OMRI resonators at 15 mTesla. As expected, the MRI S/N ratio was improved by a factor of 30. Triplet dynamic nuclear polarization spectra were observed for 14 N carboxy-PROXYL, along the excitation microwave sweep. In the current setup, the enhancement factor was ca. 0.5. In conclusion, the results of this preliminary evaluation indicate that the 0.15 Tesla OMRI could be useful for free radical measurement for small samples.

  13. 1.5 versus 3 versus 7 Tesla in abdominal MRI: A comparative study.

    Science.gov (United States)

    Laader, Anja; Beiderwellen, Karsten; Kraff, Oliver; Maderwald, Stefan; Wrede, Karsten; Ladd, Mark E; Lauenstein, Thomas C; Forsting, Michael; Quick, Harald H; Nassenstein, Kai; Umutlu, Lale

    2017-01-01

    The aim of this study was to investigate and compare the feasibility as well as potential impact of altered magnetic field properties on image quality and potential artifacts of 1.5 Tesla, 3 Tesla and 7 Tesla non-enhanced abdominal MRI. Magnetic Resonance (MR) imaging of the upper abdomen was performed in 10 healthy volunteers on a 1.5 Tesla, a 3 Tesla and a 7 Tesla MR system. The study protocol comprised a (1) T1-weighted fat-saturated spoiled gradient-echo sequence (2D FLASH), (2) T1-weighted fat-saturated volumetric interpolated breath hold examination sequence (3D VIBE), (3) T1-weighted 2D in and opposed phase sequence, (4) True fast imaging with steady-state precession sequence (TrueFISP) and (5) T2-weighted turbo spin-echo (TSE) sequence. For comparison reasons field of view and acquisition times were kept comparable for each correlating sequence at all three field strengths, while trying to achieve the highest possible spatial resolution. Qualitative and quantitative analyses were tested for significant differences. While 1.5 and 3 Tesla MRI revealed comparable results in all assessed features and sequences, 7 Tesla MRI yielded considerable differences in T1 and T2 weighted imaging. Benefits of 7 Tesla MRI encompassed an increased higher spatial resolution and a non-enhanced hyperintense vessel signal at 7 Tesla, potentially offering a more accurate diagnosis of abdominal parenchymatous and vasculature disease. 7 Tesla MRI was also shown to be more impaired by artifacts, including residual B1 inhomogeneities, susceptibility and chemical shift artifacts, resulting in reduced overall image quality and overall image impairment ratings. While 1.5 and 3 Tesla T2w imaging showed equivalently high image quality, 7 Tesla revealed strong impairments in its diagnostic value. Our results demonstrate the feasibility and overall comparable imaging ability of T1-weighted 7 Tesla abdominal MRI towards 3 Tesla and 1.5 Tesla MRI, yielding a promising diagnostic potential for

  14. Surface-Induced Dissociation of Protein Complexes in a Hybrid Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Jing; Zhou, Mowei; Gilbert, Joshua D.; Wolff, Jeremy J.; Somogyi, Árpád; Pedder, Randall E.; Quintyn, Royston S.; Morrison, Lindsay J.; Easterling, Michael L.; Paša-Tolić, Ljiljana; Wysocki, Vicki H.

    2017-01-03

    Mass spectrometry continues to develop as a valuable tool in the analysis of proteins and protein complexes. In protein complex mass spectrometry studies, surface-induced dissociation (SID) has been successfully applied in quadrupole time-of-flight (Q-TOF) instruments. SID provides structural information on non-covalent protein complexes that is complementary to other techniques. However, the mass resolution of Q-TOF instruments can limit the information that can be obtained for protein complexes by SID. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) provides ultrahigh resolution and ultrahigh mass accuracy measurements. In this study, an SID device was designed and successfully installed in a hybrid FT-ICR instrument in place of the standard gas collision cell. The SID-FT-ICR platform has been tested with several protein complex systems (homooligomers, a heterooligomer, and a protein-ligand complex, ranging from 53 kDa to 85 kDa), and the results are consistent with data previously acquired on Q-TOF platforms, matching predictions from known protein interface information. SID fragments with the same m/z but different charge states are well-resolved based on distinct spacing between adjacent isotope peaks, and the addition of metal cations and ligands can also be isotopically resolved with the ultrahigh mass resolution available in FT-ICR.

  15. Functionality of veterinary identification microchips following low- (0.5 tesla) and high-field (3 tesla) magnetic resonance imaging.

    Science.gov (United States)

    Piesnack, Susann; Frame, Mairi E; Oechtering, Gerhard; Ludewig, Eberhard

    2013-01-01

    The ability to read patient identification microchips relies on the use of radiofrequency pulses. Since radiofrequency pulses also form an integral part of the magnetic resonance imaging (MRI) process, the possibility of loss of microchip function during MRI scanning is of concern. Previous clinical trials have shown microchip function to be unaffected by MR imaging using a field strength of 1 Tesla and 1.5. As veterinary MRI scanners range widely in field strength, this study was devised to determine whether exposure to lower or higher field strengths than 1 Tesla would affect the function of different types of microchip. In a phantom study, a total of 300 International Standards Organisation (ISO)-approved microchips (100 each of three different types: ISO FDX-B 1.4 × 9 mm, ISO FDX-B 2.12 × 12 mm, ISO HDX 3.8 × 23 mm) were tested in a low field (0.5) and a high field scanner (3.0 Tesla). A total of 50 microchips of each type were tested in each scanner. The phantom was composed of a fluid-filled freezer pack onto which a plastic pillow and a cardboard strip with affixed microchips were positioned. Following an MRI scan protocol simulating a head study, all of the microchips were accurately readable. Neither 0.5 nor 3 Tesla imaging affected microchip function in this study. © 2013 Veterinary Radiology & Ultrasound.

  16. Gas phase ion/molecule reactions as studied by Fourier Transform Ion Cyclotron Resonance mass spectrometry

    International Nuclear Information System (INIS)

    Joergensen, S.I.

    1985-01-01

    The subject of this thesis is gas phase ion/molecule reactions as studied by Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry (chapter 2 contains a short description of this method). Three chapters are mainly concerned with mechanistic aspects of gas phase ion/molecule reactions. An equally important aspect of the thesis is the stability and reactivity of α-thio carbanions, dipole stabilized carbanions and homoenolate anions, dealt with in the other four chapters. (Auth.)

  17. Ion detection in mass spectrometry

    International Nuclear Information System (INIS)

    Bolbach, Gerard

    2016-03-01

    This course aims at providing some elements for a better understanding of ion detectors used in mass spectrometers, of their operations, and of their limitations. A first part addresses the functions and properties of an ideal detector, how to detect ions in gas phase, and particle detectors and ion detectors used in mass spectrometry. The second part proposes an overview of currently used detectors with respect to their operation principle: detection from the ion charge (Faraday cylinder), detection by inductive effects (FTICR, Fourier Transform Ion Cyclotron Resonance), and detection by secondary electron emission. The third part discusses the specificities of secondary electron emission. The fourth one addresses operating modes and parameters related to detectors. The sixth part proposes a prospective view on future detectors by addressing the following issues: cryo-detector, inductive effect and charge detectors, ion detection and nano materials

  18. Atmospheric pressure chemical ionization Fourier transform ion cyclotron resonance mass spectrometry for complex thiophenic mixture analysis

    KAUST Repository

    Hourani, Nadim

    2013-10-01

    Rationale Polycyclic aromatic sulfur heterocycles (PASHs) are detrimental species for refining processes in petroleum industry. Current mass spectrometric Methods that determine their composition are often preceded by derivatization and dopant addition approaches. Different ionization Methods have different impact on the molecular assignment of complex PASHs. The analysis of such species under atmospheric pressure chemical ionization (APCI) is still considered limited due to uncontrolled ion generation with low- and high-mass PASHs. Methods The ionization behavior of a model mixture of five selected PASH standards was investigated using an APCI source with nitrogen as the reagent gas. A complex thiophenic fraction was separated from a vacuum gas oil (VGO) and injected using the same method. The samples were analyzed using Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS). RESULTS PASH model analytes were successfully ionized and mainly [M + H]+ ions were produced. The same ionization pattern was observed for the real thiophenic sample. It was found that S1 class species were the major sulfur-containing species found in the VGO sample. These species indicated the presence of alkylated benzothiophenic (BT), dibenzothiophenic (DBT) and benzonaphthothiophenic (BNT) series that were detected by APCI-FTICR MS. CONCLUSIONS This study provides an established APCI-FTICR MS method for the analysis of complex PASHs. PASHs were detected without using any derivatization and without fragmentation. The method can be used for the analysis of S-containing crude oil samples. © 2013 John Wiley & Sons, Ltd.

  19. Quantification of Liver Proton-Density Fat Fraction in an 7.1 Tesla preclinical MR Systems: Impact of the Fitting Technique

    Science.gov (United States)

    Mahlke, C; Hernando, D; Jahn, C; Cigliano, A; Ittermann, T; Mössler, A; Kromrey, ML; Domaska, G; Reeder, SB; Kühn, JP

    2016-01-01

    Purpose To investigate the feasibility of estimating the proton-density fat fraction (PDFF) using a 7.1 Tesla magnetic resonance imaging (MRI) system and to compare the accuracy of liver fat quantification using different fitting approaches. Materials and Methods Fourteen leptin-deficient ob/ob mice and eight intact controls were examined in a 7.1 Tesla animal scanner using a 3-dimensional six-echo chemical shift-encoded pulse sequence. Confounder-corrected PDFF was calculated using magnitude (magnitude data alone) and combined fitting (complex and magnitude data). Differences between fitting techniques were compared using Bland-Altman analysis. In addition, PDFFs derived with both reconstructions were correlated with histopathological fat content and triglyceride mass fraction using linear regression analysis. Results The PDFFs determined with use of both reconstructions correlated very strongly (r=0.91). However, small mean bias between reconstructions demonstrated divergent results (3.9%; CI 2.7%-5.1%). For both reconstructions, there was linear correlation with histopathology (combined fitting: r=0.61; magnitude fitting: r=0.64) and triglyceride content (combined fitting: r=0.79; magnitude fitting: r=0.70). Conclusion Liver fat quantification using the PDFF derived from MRI performed at 7.1 Tesla is feasible. PDFF has strong correlations with histopathologically determined fat and with triglyceride content. However, small differences between PDFF reconstruction techniques may impair the robustness and reliability of the biomarker at 7.1 Tesla. PMID:27197806

  20. Contribution to study and realization of 20-Tesla superconducting magnet

    International Nuclear Information System (INIS)

    Marty, J.

    1981-11-01

    This work is mainly concerned with 20 Tesla induction production study. This magnetic induction should be produced by associating a series of coils using high critical field commercial: superconductors to the 10 Tesla magnet (diameter: 300; let's call it 10-300 magnet). The operation temperature lowering from 4,2 0 K to 1,8 0 K should effectively lead to much higher inductions (with equal effective diameter) than the greatest performances nowadays realized at 4,2 0 K temperature. To this performance augmentation is associated a more important energy density augmentation. This leads to the necessity of the knowledge of the superconducting material physical properties. They are studied in this report. Following, different methodes of magnet calculations are described: problems related to mechanical constraints, protection and stability must be known. Finally, some coils of the 10-300 magnet are presented together with their realization [fr

  1. Living laboratory for Nikola Tesla. Living laboratories, Tesla, Second Life, sustainable construction technologies and renewable energy sources; Wohnlabor fuer Nikola Tesla. Ueber Wohnlabors, Tesla, Second Life, nachhaltige Bautechnologien und erneuerbare Energie

    Energy Technology Data Exchange (ETDEWEB)

    Redi, Ivan; Redi, Andrea; Jovanovic, Branimir (and others)

    2008-07-01

    Adventure is the opposite of conventional teaching. Adventure is the moment when experience alone is not enough. Sometimes, courageous people challenge the nature of things, helping us to get new insights and achieve a new viewpoint. The experience-oriented ''work in progress'' university is an adventure of this kind. The book looks into the Tesla laboratory and the Wardenclyffe Tower, both of which could not be completed for financial reasons, and addresses them from today's state of technology. The conceptional section is based on the ''Tesla doctrine'' which comprises fundamental philosophical statements on civilisatory progress. The book presents the results of the investigation. The 16 architectural projects presented here were developed live on the online platform. Second Life, ORTLOS Sim. (orig.)

  2. Simulations of the Static Tuning for the TESLA Linear Collider

    CERN Document Server

    Schulte, Daniel

    2003-01-01

    At the heart of the TESLA linear collider are the two 10 km long superconducting linacs. A linac is constructed from 858 cryomodules each containing 12 nine-cell 1.3 GHz superconducting cavities. 355 quadrupoles provide the necessary beam focusing. The advantages of low-frequency superconducting RF in terms of wakefield behaviour are well known, and the TESLA alignment tolerances are relatively loose. However, the effects of cavity tilts and their impact of the linac beam-based alignment algorithms have until recently not been fully investigated. In addition, the strong sensitivity to correlated emittance growth due to the high beam-beam disruption parameter makes it desirable to control the linac emittance down to a few percent. In this report we discuss various static tuning algorithms and present new simulation results. Discussions of the relative merits and applicability of the methods is also discussed.

  3. Performance of TESLA Cavities After Fabrication and Preparation in Industry

    CERN Document Server

    Pekeler, Michael; Bauer, Stefan; Knobloch, Jens; Vom Stein, Peter

    2005-01-01

    In order to demonstrate cw operation of TESLA cavities in linear accelerators driving FEL applications, two TESLA cavities were manufactured and prepared by ACCEL for BESSY. After production, both cavities were prepared for vertical test at ACCEL's premises using state of the art chemical polishing and high pressure water rinsing techniques. The cavities were tested in DESY's vertical RF test installation. Accelerating gradients close to 25 MV/m were reached. One cavity was completed with a helium vessel modified for cw operation and prepared with chemical polishing, high pressure water rinsing, and assembled with the required High Power Coupler at ACCEL. The fully dressed cavity was then shipped under vacuum to BESSY and tested in the horizontal cryostat HoBiCaT. Horizontal RF test results will be presented and compared with the vertical test results.

  4. Soil moisture determination with Tesla NZK 203 neutron gage

    International Nuclear Information System (INIS)

    Hally, J.

    1977-01-01

    Soil moisture was measured using the NZK 203 neutron probe manufactured by Tesla Premysleni. The individual measuring sites were spaced at a distance of 100 m. The NZK 203 set consists of a NPK 202 moisture gage and a NSK 301 scintillation detector and features the following specifications: moisture density measuring range 20 to 500 kg/m 3 , 241 Am-Be fast neutron source having a neutron flux of 7.5x10 4 n.sec -1 +-10%, operating temperature -10 to +45 degC. The measured counting rate was primarily affected by the statistical fluctuation of ionizing radiation and by instrument instability. In order that these effects should be limited each measurement was repeated 10 times with the optimum measurement time at an interval of 20 to 100 sec. The NZK 203 Tesla set was proven to be suitable for rapid and reproducible determination of moisture profiles. (J.P.)

  5. SRS Behaviour with a superconducting 5-Tesla wiggler insertion

    International Nuclear Information System (INIS)

    Suller, V.P.; Marks, N.; Poole, M.W.; Walker, R.P.

    1983-01-01

    A 5 Tesla superconducting wavelength shifting wiggler magnet has been inserted into the SRS lattice. Observations have been made of the behaviour of the stored electron beam with the magnet powered. Betatron tune shifts and modulation of the betatron function have been measured and good agreement obtained with theory. Closed orbit changes have been examined and the stored beam lifetime optimised. The magnet is fully operational and is producing intense x-ray beams for users

  6. Business Model Design: Lessons Learned from Tesla Motors

    OpenAIRE

    Chen , Yurong; Perez , Yannick

    2015-01-01

    International audience; Electric vehicle (EV) industry is still in the introduction stage in product life cycle, and dominant design remains unclear. EV companies, both incumbent from the car industry and new comers, have long taken numerous endeavors to promote EV in the niche market by providing innovative products and business models. While most carmakers still take 'business as usual' approach for developing their EV production and offers, Tesla Motors, an EV entrepreneurial firm, stands ...

  7. Elon Musk – riskanter Milliardenpoker um Tesla & Co.

    OpenAIRE

    Lipp, Reto

    2017-01-01

    Interview von Reto Lipp mit Peter Leibfried (SRF ECO): Von seinen Fans wird er wie ein Rockstar gefeiert. Ob Tesla, Solar City oder SpaceX, Elon Musk will die Welt revolutionieren. Doch seine Visionen verschlingen Unsummen. Bisher ist es ihm stets gelungen, neue Gelder zu mobilisieren und bei Bedarf Millionenbeträge zwischen seinen Unternehmen hin und her zu schieben. Doch das Firmenimperium lebt von riesigen Erwartungen der Investoren. Kann Elon Musk sie nicht einlösen, droht der Kollaps.

  8. Using 3 Tesla magnetic resonance imaging in the pre-operative evaluation of tongue carcinoma.

    Science.gov (United States)

    Moreno, K F; Cornelius, R S; Lucas, F V; Meinzen-Derr, J; Patil, Y J

    2017-09-01

    This study aimed to evaluate the role of 3 Tesla magnetic resonance imaging in predicting tongue tumour thickness via direct and reconstructed measures, and their correlations with corresponding histological measures, nodal metastasis and extracapsular spread. A prospective study was conducted of 25 patients with histologically proven squamous cell carcinoma of the tongue and pre-operative 3 Tesla magnetic resonance imaging from 2009 to 2012. Correlations between 3 Tesla magnetic resonance imaging and histological measures of tongue tumour thickness were assessed using the Pearson correlation coefficient: r values were 0.84 (p Tesla magnetic resonance imaging had 83 per cent sensitivity, 82 per cent specificity, 82 per cent accuracy and a 90 per cent negative predictive value for detecting cervical lymph node metastasis. In this cohort, 3 Tesla magnetic resonance imaging measures of tumour thickness correlated highly with the corresponding histological measures. Further, 3 Tesla magnetic resonance imaging was an effective method of detecting malignant adenopathy with extracapsular spread.

  9. Development of a 1.0 MV 100 Hz compact tesla transformer with PFL

    International Nuclear Information System (INIS)

    Kang Qiang; Chang Anbi; Li Mingjia; Meng Fanbao; Su Youbin

    2006-01-01

    The theory and characteristic of a compact Tesla transformer are introduced, and an unitized configuration design is performed for 1.0 MV, 100 Hz Tesla transformer and 40 Ω, 40 ns pulse forming line (PFL). Two coaxial open cores in Tesla transformer serve as the inner and outer conductors of PFL, and a traditional PFL is combined with the Tesla transformer, then the pulse generator can be smaller, more efficient, and more stable. The designed compact Tesla transformer employed in electron beams accelerator CHP01 can charge PFL of 600 pF for 1.3 MV voltage at a single shot, and keep 1.15 MV at 100 Hz repeated rates. Furthermore, a continuance run in 5 seconds is achieved by Tesla transformer under voltage and frequency ratings. (authors)

  10. Cryogenic system for the 45 Tesla hybrid magnet

    International Nuclear Information System (INIS)

    Van Sciver, S.W.; Miller, J.R.; Welton, S.; Schneider-Muntau, H.J.; McIntosh, G.E.

    1994-01-01

    The 45 Tesla hybrid magnet system will consist of a 14 Tesla superconducting outsert magnet and a 31 Tesla water cooled insert. The magnet is planned for operation in early 1995 at the National High Magnetic Field Laboratory. Its purpose is to provide the highest DC magnetic fields for the materials research community. The present paper discusses the overall design of the cryogenic system for the superconducting magnet. Unique features of this system include static 1.8 K pressurized He II as a coolant for the magnet and a refrigerated structural support system for load transfer during fault conditions. The system will consist of two connected cryostats. The magnet is contained within one cryostat which has a clear warm bore of 616 mm and is designed to be free of system interfaces and therefore minimize interference with the magnet user. A second supply cryostat provides the connections to the refrigeration system and magnet power supply. The magnet and supply cryostats are connected to each other through a horizontal services duct section. Issues to be discussed in the present paper include design and thermal analysis of the magnet system during cooldown and in steady state operation and overall cryogenic system design

  11. RHQT Nb3Al 15-Tesla magnet design study

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, R.; Ambrosio, G.; Barzi, E.; Kashikin, V.; Kikuchi, A.; Novitski, I.; Takeuchi, T.; Wake, M.; Zlobin, A.; /Fermilab /NIMC, Tsukuba /KEK, Tsukuba

    2005-09-01

    Feasibility study of 15-Tesla dipole magnets wound with a new copper stabilized RHQT Nb{sub 3}Al Rutherford cable is presented. A new practical long copper stabilized RHQT Nb{sub 3}Al strand is presented, which is being developed and manufactured at the National Institute of Material Science (NIMS) in Japan. It has achieved a non-copper J{sub c} of 1000A/mm{sup 2} at 15 Tesla at 4.2K, with a copper over non-copper ratio of 1.04, and a filament size less than 50 microns. For this design study a short Rutherford cable with 28 Nb{sub 3}Al strands of 1 mm diameter will be fabricated late this year. The cosine theta magnet cross section is designed using ROXIE, and the stress and strain in the coil is estimated and studied with the characteristics of the Nb{sub 3}Al strand. The advantages and disadvantages of the Nb{sub 3}Al cable are compared with the prevailing Nb{sub 3}Sn cable from the point of view of stress-strain, J{sub c}, and possible degradation of stabilizer due to cabling. The Nb{sub 3}Al coil of the magnet, which will be made by wind and react method, has to be heat treated at 800 degree C for 10 hours. As preparation for the 15 Tesla magnet, a series of tests on strand and Rutherford cables are considered.

  12. Simulation Model solves exact the Enigma named Generating high Voltages and high Frequencies by Tesla Coil

    OpenAIRE

    Simo Janjanin

    2016-01-01

    Simulation model of Tesla coil has been successfully completed, and has been verified the procedure and functioning. The literature and documentation for the model were taken from the rich sources, especially the copies of Tesla patents. The oscillating system‟s electrical scheme consists of the voltage supply 220/50 Hz, Fe transformer, capacitor and belonging chosen electrical components, the air gap in the primary Tesla coil (air transformer) and spark gap in the exit of the coil. The inves...

  13. Non-enhanced MR imaging of cerebral arteriovenous malformations at 7 Tesla

    International Nuclear Information System (INIS)

    Wrede, Karsten H.; Dammann, Philipp; Johst, Soeren; Maderwald, Stefan; Moenninghoff, Christoph; Forsting, Michael; Schlamann, Marc; Sandalcioglu, I.E.; Ladd, Mark E.; Sure, Ulrich; Umutlu, Lale

    2016-01-01

    To evaluate prospectively 7 Tesla time-of-flight (TOF) magnetic resonance angiography (MRA) and 7 Tesla non-contrast-enhanced magnetization-prepared rapid acquisition gradient-echo (MPRAGE) for delineation of intracerebral arteriovenous malformations (AVMs) in comparison to 1.5 Tesla TOF MRA and digital subtraction angiography (DSA). Twenty patients with single or multifocal AVMs were enrolled in this trial. The study protocol comprised 1.5 and 7 Tesla TOF MRA and 7 Tesla non-contrast-enhanced MPRAGE sequences. All patients underwent an additional four-vessel 3D DSA. Image analysis of the following five AVM features was performed individually by two radiologists on a five-point scale: nidus, feeder(s), draining vein(s), relationship to adjacent vessels, and overall image quality and presence of artefacts. A total of 21 intracerebral AVMs were detected. Both sequences at 7 Tesla were rated superior over 1.5 Tesla TOF MRA in the assessment of all considered AVM features. Image quality at 7 Tesla was comparable with DSA considering both sequences. Inter-observer accordance was good to excellent for the majority of ratings. This study demonstrates excellent image quality for depiction of intracerebral AVMs using non-contrast-enhanced 7 Tesla MRA, comparable with DSA. Assessment of untreated AVMs is a promising clinical application of ultra-high-field MRA. (orig.)

  14. Non-enhanced MR imaging of cerebral arteriovenous malformations at 7 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Wrede, Karsten H.; Dammann, Philipp [University Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany); University Hospital Essen, Department of Neurosurgery, Essen (Germany); Johst, Soeren; Maderwald, Stefan [University Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany); Moenninghoff, Christoph; Forsting, Michael [University Hospital Essen, Department of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Schlamann, Marc [University Hospital Essen, Department of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); University Hospital Giessen, Department of Neuroradiology, Giessen (Germany); Sandalcioglu, I.E. [University Hospital Essen, Department of Neurosurgery, Essen (Germany); Nordstadtkrankenhaus Hannover, Department of Neurosurgery, Hannover (Germany); Ladd, Mark E. [University Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany); University Hospital Essen, Department of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); German Cancer Research Center (DKFZ), Division of Medical Physics in Radiology (E020), Heidelberg (Germany); Sure, Ulrich [University Hospital Essen, Department of Neurosurgery, Essen (Germany); Umutlu, Lale [University Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany); University Hospital Essen, Department of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany)

    2016-03-15

    To evaluate prospectively 7 Tesla time-of-flight (TOF) magnetic resonance angiography (MRA) and 7 Tesla non-contrast-enhanced magnetization-prepared rapid acquisition gradient-echo (MPRAGE) for delineation of intracerebral arteriovenous malformations (AVMs) in comparison to 1.5 Tesla TOF MRA and digital subtraction angiography (DSA). Twenty patients with single or multifocal AVMs were enrolled in this trial. The study protocol comprised 1.5 and 7 Tesla TOF MRA and 7 Tesla non-contrast-enhanced MPRAGE sequences. All patients underwent an additional four-vessel 3D DSA. Image analysis of the following five AVM features was performed individually by two radiologists on a five-point scale: nidus, feeder(s), draining vein(s), relationship to adjacent vessels, and overall image quality and presence of artefacts. A total of 21 intracerebral AVMs were detected. Both sequences at 7 Tesla were rated superior over 1.5 Tesla TOF MRA in the assessment of all considered AVM features. Image quality at 7 Tesla was comparable with DSA considering both sequences. Inter-observer accordance was good to excellent for the majority of ratings. This study demonstrates excellent image quality for depiction of intracerebral AVMs using non-contrast-enhanced 7 Tesla MRA, comparable with DSA. Assessment of untreated AVMs is a promising clinical application of ultra-high-field MRA. (orig.)

  15. Hippocampal MRI volumetry at 3 Tesla: reliability and practical guidance.

    Science.gov (United States)

    Jeukens, Cécile R L P N; Vlooswijk, Mariëlle C G; Majoie, H J Marian; de Krom, Marc C T F M; Aldenkamp, Albert P; Hofman, Paul A M; Jansen, Jacobus F A; Backes, Walter H

    2009-09-01

    Although volumetry of the hippocampus is considered to be an established technique, protocols reported in literature are not described in great detail. This article provides a complete and detailed protocol for hippocampal volumetry applicable to T1-weighted magnetic resonance (MR) images acquired at 3 Tesla, which has become the standard for structural brain research. The protocol encompasses T1-weighted image acquisition at 3 Tesla, anatomic guidelines for manual hippocampus delineation, requirements of delineation software, reliability measures, and criteria to assess and ensure sufficient reliability. Moreover, the validity of the correction for total intracranial volume size was critically assessed. The protocol was applied by 2 readers to the MR images of 36 patients with cryptogenic localization-related epilepsy, 4 patients with unilateral hippocampal sclerosis, and 20 healthy control subjects. The uncorrected hippocampal volumes were 2923 +/- 500 mm3 (mean +/- SD) (left) and 3120 +/- 416 mm3 (right) for the patient group and 3185 +/- 411 mm3 (left) and 3302 +/- 411 mm3 (right) for the healthy control group. The volume of the 4 pathologic hippocampi of the patients with unilateral hippocampal sclerosis was 2980 +/- 422 mm3. The inter-reader reliability values were determined: intraclass-correlation-coefficient (ICC) = 0.87 (left) and 0.86 (right), percentage volume difference (VD) = 7.0 +/- 4.7% (left) and 6.0 +/- 3.8% (right), and overlap ratio (OR) = 0.82 +/- 0.04 (left) and 0.82 +/- 0.03 (right). The positive Pearson correlation between hippocampal volume and total intracranial volume was found to be low: r = 0.48 (P = 0.03, left) and r = 0.62 (P = 0.004, right) and did not significantly reduce the volumetric variances, showing the limited benefit of the brain size correction. A protocol was described to determine hippocampal volumes based on 3 Tesla MR images with high inter-reader reliability. Although the reliability of hippocampal volumetry at 3 Tesla

  16. Canine body composition quantification using 3 tesla fat-water MRI.

    Science.gov (United States)

    Gifford, Aliya; Kullberg, Joel; Berglund, Johan; Malmberg, Filip; Coate, Katie C; Williams, Phillip E; Cherrington, Alan D; Avison, Malcolm J; Welch, E Brian

    2014-02-01

    To test the hypothesis that a whole-body fat-water MRI (FWMRI) protocol acquired at 3 Tesla combined with semi-automated image analysis techniques enables precise volume and mass quantification of adipose, lean, and bone tissue depots that agree with static scale mass and scale mass changes in the context of a longitudinal study of large-breed dogs placed on an obesogenic high-fat, high-fructose diet. Six healthy adult male dogs were scanned twice, at weeks 0 (baseline) and 4, of the dietary regiment. FWMRI-derived volumes of adipose tissue (total, visceral, and subcutaneous), lean tissue, and cortical bone were quantified using a semi-automated approach. Volumes were converted to masses using published tissue densities. FWMRI-derived total mass corresponds with scale mass with a concordance correlation coefficient of 0.931 (95% confidence interval = [0.813, 0.975]), and slope and intercept values of 1.12 and -2.23 kg, respectively. Visceral, subcutaneous and total adipose tissue masses increased significantly from weeks 0 to 4, while neither cortical bone nor lean tissue masses changed significantly. This is evidenced by a mean percent change of 70.2% for visceral, 67.0% for subcutaneous, and 67.1% for total adipose tissue. FWMRI can precisely quantify and map body composition with respect to adipose, lean, and bone tissue depots. The described approach provides a valuable tool to examine the role of distinct tissue depots in an established animal model of human metabolic disease. Copyright © 2013 Wiley Periodicals, Inc.

  17. Hip imaging of avascular necrosis at 7 Tesla compared with 3 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Theysohn, J.M.; Kraff, O.; Theysohn, N.; Orzada, S.; Lauenstein, T.C. [University Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany); University Hospital Essen, Institute for Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Landgraeber, S. [University Hospital Essen, Department of Orthopedic Surgery, Essen (Germany); Ladd, M.E. [University Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany); German Cancer Research Center, Department of Medical Physics in Radiology, Heidelberg (Germany)

    2014-05-15

    To compare ultra-high field, high-resolution bilateral magnetic resonance imaging (MRI) of the hips at 7 Tesla (T) with 3 T MRI in patients with avascular necrosis (AVN) of the femoral head by subjective image evaluations, contrast measurements, and evaluation of the appearance of imaging abnormalities. Thirteen subjects with avascular necrosis treated using advanced core decompression underwent MRI at both 7 T and 3 T. Sequence parameters as well as resolution were kept identical for both field strengths. All MR images (MEDIC, DESS, PD/T2w TSE, T1w TSE, and STIR) were evaluated by two radiologists with regard to subjective image quality, soft tissue contrasts, B1 homogeneity (four-point scale, higher values indicating better image quality) and depiction of imaging abnormalities of the femoral heads (three-point scale, higher values indicating the superiority of 7 T). Contrast ratios of soft tissues were calculated and compared with subjective data. 7-T imaging of the femoral joints, as well as 3-T imaging, achieved ''good'' to ''very good'' quality in all sequences. 7 T showed significantly higher soft tissue contrasts for T2w and MEDIC compared with 3 T (cartilage/fluid: 2.9 vs 2.2 and 3.6 vs 2.6), better detailed resolution for cartilage defects (PDw, T2w, T1w, MEDIC, DESS > 2.5) and better visibility of joint effusions (MEDIC 2.6; PDw/T2w 2.4; DESS 2.2). Image homogeneity compared with 3 T (3.9-4.0 for all sequences) was degraded, especially in TSE sequences at 7 T through signal variations (7 T: 2.1-2.9); to a lesser extent also GRE sequences (7 T: 2.9-3.5). Imaging findings related to untreated or treated AVN were better delineated at 3 T (≤1.8), while joint effusions (2.2-2.6) and cartilage defects (2.5-3.0) were better visualized at 7 T. STIR performed much more poorly at 7 T, generating large contrast variations (1.5). 7-T hip MRI showed comparable results in hip joint imaging compared with 3 T with slight

  18. Hip imaging of avascular necrosis at 7 Tesla compared with 3 Tesla

    International Nuclear Information System (INIS)

    Theysohn, J.M.; Kraff, O.; Theysohn, N.; Orzada, S.; Lauenstein, T.C.; Landgraeber, S.; Ladd, M.E.

    2014-01-01

    To compare ultra-high field, high-resolution bilateral magnetic resonance imaging (MRI) of the hips at 7 Tesla (T) with 3 T MRI in patients with avascular necrosis (AVN) of the femoral head by subjective image evaluations, contrast measurements, and evaluation of the appearance of imaging abnormalities. Thirteen subjects with avascular necrosis treated using advanced core decompression underwent MRI at both 7 T and 3 T. Sequence parameters as well as resolution were kept identical for both field strengths. All MR images (MEDIC, DESS, PD/T2w TSE, T1w TSE, and STIR) were evaluated by two radiologists with regard to subjective image quality, soft tissue contrasts, B1 homogeneity (four-point scale, higher values indicating better image quality) and depiction of imaging abnormalities of the femoral heads (three-point scale, higher values indicating the superiority of 7 T). Contrast ratios of soft tissues were calculated and compared with subjective data. 7-T imaging of the femoral joints, as well as 3-T imaging, achieved ''good'' to ''very good'' quality in all sequences. 7 T showed significantly higher soft tissue contrasts for T2w and MEDIC compared with 3 T (cartilage/fluid: 2.9 vs 2.2 and 3.6 vs 2.6), better detailed resolution for cartilage defects (PDw, T2w, T1w, MEDIC, DESS > 2.5) and better visibility of joint effusions (MEDIC 2.6; PDw/T2w 2.4; DESS 2.2). Image homogeneity compared with 3 T (3.9-4.0 for all sequences) was degraded, especially in TSE sequences at 7 T through signal variations (7 T: 2.1-2.9); to a lesser extent also GRE sequences (7 T: 2.9-3.5). Imaging findings related to untreated or treated AVN were better delineated at 3 T (≤1.8), while joint effusions (2.2-2.6) and cartilage defects (2.5-3.0) were better visualized at 7 T. STIR performed much more poorly at 7 T, generating large contrast variations (1.5). 7-T hip MRI showed comparable results in hip joint imaging compared with 3 T with slight advantages in contrast detail (cartilage defects

  19. Non-Enhanced MR Imaging of Cerebral Arteriovenous Malformations at 7 Tesla.

    Science.gov (United States)

    Wrede, Karsten H; Dammann, Philipp; Johst, Sören; Mönninghoff, Christoph; Schlamann, Marc; Maderwald, Stefan; Sandalcioglu, I Erol; Ladd, Mark E; Forsting, Michael; Sure, Ulrich; Umutlu, Lale

    2016-03-01

    To evaluate prospectively 7 Tesla time-of-flight (TOF) magnetic resonance angiography (MRA) and 7 Tesla non-contrast-enhanced magnetization-prepared rapid acquisition gradient-echo (MPRAGE) for delineation of intracerebral arteriovenous malformations (AVMs) in comparison to 1.5 Tesla TOF MRA and digital subtraction angiography (DSA). Twenty patients with single or multifocal AVMs were enrolled in this trial. The study protocol comprised 1.5 and 7 Tesla TOF MRA and 7 Tesla non-contrast-enhanced MPRAGE sequences. All patients underwent an additional four-vessel 3D DSA. Image analysis of the following five AVM features was performed individually by two radiologists on a five-point scale: nidus, feeder(s), draining vein(s), relationship to adjacent vessels, and overall image quality and presence of artefacts. A total of 21 intracerebral AVMs were detected. Both sequences at 7 Tesla were rated superior over 1.5 Tesla TOF MRA in the assessment of all considered AVM features. Image quality at 7 Tesla was comparable with DSA considering both sequences. Inter-observer accordance was good to excellent for the majority of ratings. This study demonstrates excellent image quality for depiction of intracerebral AVMs using non-contrast-enhanced 7 Tesla MRA, comparable with DSA. Assessment of untreated AVMs is a promising clinical application of ultra-high-field MRA. • Non-contrast-enhanced 7 Tesla MRA demonstrates excellent image quality for intracerebral AVM depiction. • Image quality at 7 Tesla was comparable with DSA considering both sequences. • Assessment of intracerebral AVMs is a promising clinical application of ultra-high-field MRA.

  20. Diffusion tensor imaging of the normal prostate at 3 Tesla

    International Nuclear Information System (INIS)

    Guerses, Bengi; Kabakci, Neslihan; Kovanlikaya, Arzu; Firat, Zeynep; Bayram, Ali; Kovanlikaya, Ilhami; Ulud, Aziz M.

    2008-01-01

    The aim of this study was to assess the feasibility of diffusion tensor imaging (DTI) of the prostate and to determine normative fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of healthy prostate with a 3-Tesla magnetic resonance imaging (MRI) system. Thirty volunteers with a mean age of 28 (25-35) years were scanned with a 3-Tesla MRI (Intera Achieva; Philips, The Netherlands) system using a six-channel phased array coil. Initially, T2-weighted turbo spin-echo (TSE) axial images of the prostate were obtained. In two subjects, a millimetric hypointense signal change was detected in the peripheral zones on T2-weighted TSE images. These two subjects were excluded from the study. DTI with single-shot echo-planar imaging (ssEPI) was performed in the remaining 28 subjects. ADC and FA values were measured using the manufacturer supplied software by positioning 9-pixel ROIs on each zone. Differences between parameters of the central and peripheral zones were assessed. Mean ADC value of the central (1.220 ± 0.271 x 10 -3 mm 2 /s) was found to be significantly lower when compared with the peripheral gland (1.610 ± 0.347 x 10 -3 mm 2 /s) (P < 0.01). Mean FA of the central gland was significantly higher (0.26), compared with the peripheral gland (0.16) (P < 0.01). This study shows the feasibility of prostate DTI with a 3-Tesla MR system and the normative FA and ADC values of peripheral and central zones of the normal prostate. The results are compatible with the microstructural organization of the gland. (orig.)

  1. In vivo high-resolution 7 Tesla MRI shows early and diffuse cortical alterations in CADASIL.

    Science.gov (United States)

    De Guio, François; Reyes, Sonia; Vignaud, Alexandre; Duering, Marco; Ropele, Stefan; Duchesnay, Edouard; Chabriat, Hugues; Jouvent, Eric

    2014-01-01

    Recent data suggest that early symptoms may be related to cortex alterations in CADASIL (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a monogenic model of cerebral small vessel disease (SVD). The aim of this study was to investigate cortical alterations using both high-resolution T2* acquisitions obtained with 7 Tesla MRI and structural T1 images with 3 Tesla MRI in CADASIL patients with no or only mild symptomatology (modified Rankin's scale ≤1 and Mini Mental State Examination (MMSE) ≥24). Complete reconstructions of the cortex using 7 Tesla T2* acquisitions with 0.7 mm isotropic resolution were obtained in 11 patients (52.1±13.2 years, 36% male) and 24 controls (54.8±11.0 years, 42% male). Seven Tesla T2* within the cortex and cortical thickness and morphology obtained from 3 Tesla images were compared between CADASIL and control subjects using general linear models. MMSE, brain volume, cortical thickness and global sulcal morphology did not differ between groups. By contrast, T2* measured by 7 Tesla MRI was significantly increased in frontal, parietal, occipital and cingulate cortices in patients after correction for multiple testing. These changes were not related to white matter lesions, lacunes or microhemorrhages in patients having no brain atrophy compared to controls. Seven Tesla MRI, by contrast to state of the art post-processing of 3 Tesla acquisitions, shows diffuse T2* alterations within the cortical mantle in CADASIL whose origin remains to be determined.

  2. Analysis of carbon and nitrogen co-metabolism in yeast by ultrahigh-resolution mass spectrometry applying 13C- and 15N-labeled substrates simultaneously

    International Nuclear Information System (INIS)

    Blank, Lars M.; Desphande, Rahul R.; Schmid, Andreas; Hayen, Heiko

    2012-01-01

    Alternative metabolic pathways inside a cell can be deduced using stable isotopically labeled substrates. One prerequisite is accurate measurement of the labeling pattern of targeted metabolites. Experiments are generally limited to the use of single-element isotopes, mainly 13 C. Here, we demonstrate the application of direct infusion nanospray, ultrahigh-resolution Fourier transform ion cyclotron resonance-mass spectrometry (FTICR-MS) for metabolic studies using differently labeled elemental isotopes simultaneously - i.e., 13 C and 15 N - in amino acids of a total protein hydrolysate. The optimized strategy for the analysis of metabolism by a hybrid linear ion trap-FTICR-MS comprises the collection of multiple adjacent selected ion monitoring scans. By limiting both the width of the mass range and the number of ions entering the ICR cell with automated gain control, sensitive measurements of isotopologue distribution were possible without compromising mass accuracy and isotope intensity mapping. The required mass-resolving power of more than 60,000 is only achievable on a routine basis by FTICR and Orbitrap mass spectrometers. Evaluation of the method was carried out by comparison of the experimental data to the natural isotope abundances of selected amino acids and by comparison to GC/MS results obtained from a labeling experiment with 13 C-labeled glucose. The developed method was used to shed light on the complexity of the yeast Saccharomyces cerevisiae carbon-nitrogen co-metabolism by administering both 13 C-labeled glucose and 15 N-labeled alanine. The results indicate that not only glutamate but also alanine acts as an amino donor during alanine and valine synthesis. Metabolic studies using FTICR-MS can exploit new possibilities by the use of multiple-labeled elemental isotopes. (orig.)

  3. Superconducting 63-Pole 2 Tesla Wiggler for Canadian Light Source

    International Nuclear Information System (INIS)

    Khruschev, S.V.; Kuper, E.A.; Lev, V.H.; Mezentsev, N.A.; Miginsky, E.G.; Repkov, V.V.; Shkaruba, B.A.; Syrovatin, V.M.; Tsukanov, V.M.

    2006-01-01

    A superconducting 63-pole wiggler with the average period 34 mm designed and fabricated at the Institute of Nuclear Physics in Novosibirsk for Synchrotron Radiation Center (CLS) in Canada is described. The maximum field 2.2 Tesla in the median plane has been achieved. The liquid helium consumption less than 0.03 liters per hour in operating mode has been reached. In January 2005, the wiggler was installed in the storage ring in CLS and now experiments are already underway. The main parameters of the magnet and the cryogenic systems as well as test results are presented

  4. Pill-Box Cavity BPM For TESLA Cryomodul

    CERN Document Server

    Sargsyan, V

    2003-01-01

    A new cavity BPM with 10 μm resolution is designed and fabricated to perform single bunch measurements at the TESLA linear collider. In order to have a low energy dissipation in the cryogenic supermodule, the inner surface of the cavity is copper plated. Cross-talk is minimised by a special polarisation design. The electronics, at 1.5 GHz, is a homodyne receiver normalised to the bunch charge. Its LO-signal for down-conversion is taken from the same cavity.

  5. ENERGY GAIN BY MEANS OF RESONANCE IN THE TESLA COIL

    Directory of Open Access Journals (Sweden)

    Yu. Batygin

    2016-12-01

    Full Text Available An analytical review of publications on the problem, first formulated by Nikola Tesla, generating «free» energy from the air in the surrounding space has been presented. The hypothesis of the resonance phenomenon as a «key» to the air energy has been advanced. The main unsolved problem is the extrac-tion of «free» energy (proposed to call it «resonance» and its supply to the electrical load have been noted. It is expected that the quality factor of the secondary circuit must be large enough.

  6. Travelling wave accelerating structure design for TESLA positron injector linac

    CERN Document Server

    Jin, K; Zhou, F; Flöttmann, K

    2000-01-01

    A modified cup-like TW accelerating structure for TESLA Positron Pre-Accelerator (PPA) is designed by optimizing the structure geometry and by changing the iris thickness cell by cell in a section . This structure has high shunt-impedance and a large iris radius to meet with the requirements of high gradient and large transverse acceptance. The beam dynamics in the structure with the optimum solenoid focus field are studied. A satisfactory positron beam transmission and the beam performance at the PPA output have been obtained. In this paper the accelerating structure design is described in detail and the results are presented.

  7. k-t SENSE-accelerated Myocardial Perfusion MR Imaging at 3.0 Tesla - comparison with 1.5 Tesla

    Science.gov (United States)

    Plein, Sven; Schwitter, Juerg; Suerder, Daniel; Greenwood, John P.; Boesiger, Peter; Kozerke, Sebastian

    2008-01-01

    Purpose To determine the feasibility and diagnostic accuracy of high spatial resolution myocardial perfusion MR at 3.0 Tesla using k-space and time domain undersampling with sensitivity encoding (k-t SENSE). Materials and Methods The study was reviewed and approved by the local ethic review board. k-t SENSE perfusion MR was performed at 1.5 Tesla and 3.0 Tesla (saturation recovery gradient echo pulse sequence, repetition time/echo time 3.0ms/1.0ms, flip angle 15°, 5x k-t SENSE acceleration, spatial resolution 1.3×1.3×10mm3). Fourteen volunteers were studied at rest and 37 patients during adenosine stress. In volunteers, comparison was also made with standard-resolution (2.5×2.5×10mm3) 2x SENSE perfusion MR at 3.0 Tesla. Image quality, artifact scores, signal-to-noise ratios (SNR) and contrast-enhancement ratios (CER) were derived. In patients, diagnostic accuracy of visual analysis to detect >50% diameter stenosis on quantitative coronary angiography was determined by receiver-operator-characteristics (ROC). Results In volunteers, image quality and artifact scores were similar for 3.0 Tesla and 1.5 Tesla, while SNR was higher (11.6 vs. 5.6) and CER lower (1.1 vs. 1.5, p=0.012) at 3.0 Tesla. Compared with standard-resolution perfusion MR, image quality was higher for k-t SENSE (3.6 vs. 3.1, p=0.04), endocardial dark rim artifacts were reduced (artifact thickness 1.6mm vs. 2.4mm, pTesla and 1.5 Tesla, respectively. Conclusions k-t SENSE accelerated high-resolution perfusion MR at 3.0 Tesla is feasible with similar artifacts and diagnostic accuracy as at 1.5 Tesla. Compared with standard-resolution perfusion MR, image quality is improved and artifacts are reduced. PMID:18936311

  8. 76 FR 33402 - Tesla Motors, Inc.; Receipt of Petition for Renewal of Temporary Exemption from the Advanced Air...

    Science.gov (United States)

    2011-06-08

    ...-0070] Tesla Motors, Inc.; Receipt of Petition for Renewal of Temporary Exemption from the Advanced Air... Protection. SUMMARY: In accordance with the procedures in 49 CFR Part 555, Tesla Motors, Inc., has petitioned... Petition In accordance with 49 U.S.C. 30113 and the procedures in 49 CFR Part 555, Tesla Motors, Inc...

  9. Accuracy of accelerated cine MR imaging at 3 Tesla in longitudinal follow-up of cardiac function

    International Nuclear Information System (INIS)

    Sandner, Torleif A.; Huber, Armin M.; Theisen, Daniel; Reiser, Maximilian F.; Wintersperger, Bernd J.; Houck, Philip; Runge, Val M.; Sincleair, Spencer

    2008-01-01

    The ability of fast, parallel-imaging-based cine magnetic resonance (MR) to monitor global cardiac function in longitudinal exams at 3 Tesla was evaluated. Seventeen patients with chronic cardiac disease underwent serial cine MR imaging exams (n=3) at 3 Tesla. Data were acquired in short-axis orientation using cine steady-state free precession (SSFP) with a spatial resolution of 2.5 x 1.9 mm 2 at 45 ms temporal resolution. Multislice imaging (three slices/breath-hold) was performed using TSENSE acceleration (R=3) and standard single-slice cine (non-TSENSE) was performed at identical locations in consecutive breath-holds. End-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF) and myocardial mass (MM) of both cine approaches were compared for individual time-points as well as for longitudinal comparison. TSENSE-cine did not show significant differences for EDV (2.6 ml; P=.79), ESV (2.2 ml; P=0.81), EF (-0.3%; P=0.95) and MM (2.4 g; P=0.72) in comparison with non-TSENSE. Longitudinal ANOVA analysis did not reveal significant differences for any parameter, neither for non-TSENSE data (all P>0.7) nor for TSENSE data (all P>0.9). Multifactorial ANOVA showed non-significant differences (all P>0.7) at comparable data variances. Data acquisition was significantly shortened using TSENSE. Threefold accelerated multislice cine at 3 Tesla allows accurate assessment of volumetric LV data and accurate longitudinal monitoring of global LV function at a substantially shorter overall examination time. (orig.)

  10. Design of an 18 Tesla, tandem mirror, fusion reactor, hybrid choke coil

    International Nuclear Information System (INIS)

    Parmer, J.F.; Agarwal, K.; Gurol, H.; Mancuso, A.; Michels, P.H.; Peck, S.D.; Burgeson, J.; Dalder, E.N.

    1987-01-01

    A hybrid, part normal part superconducting 18-Tesla solenoid choke coil is designed for a tandem mirror fusion reactor. The present state of the art is represented by the 12-Tesla, superconducting NbSn coil. Future applications other than tandem mirror fusion devices needing high field solenoids might require hybrid magnets of the type described herein. The hybrid design was generated because of critical field performance limitations on present, practical superconducting wires. A hybrid design might be required (due to structural limits) even if the critical field were higher. Also, hybrids could be a cost-effective way of getting very high fields for certain applications. The 18-Tesla solenoid described is composed of an inner coil made of water-cooled, high-strength zirconium copper which generates 3 Tesla. A superconducting NbSn background coil contributes the remaining 15 Tesla. The focus of the design study was on the inner coil. Demonstration fabrication and testing was performed

  11. Diagnosis of rotator cuff tears using 3-Tesla MRI versus 3-Tesla MRA: a systematic review and meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    McGarvey, Ciaran; Harb, Ziad; Smith, Christian; Ajuied, Adil [Guy' s and St Thomas' Hospital, King' s Health Partners, Department of Trauma and Orthopaedics, London (United Kingdom); Houghton, Russell [Guy' s and St Thomas' Hospital, King' s Health Partners, Department of Radiology, London (United Kingdom); Corbett, Steven [Guy' s and St Thomas' Hospital, King' s Health Partners, Department of Trauma and Orthopaedics, London (United Kingdom); Fortius Clinic, London (United Kingdom)

    2016-02-15

    To compare the diagnostic accuracy of magnetic resonance imaging (MRI), 2-dimensional magnetic resonance arthrogram (MRA) and 3-dimensional isotropic MRA in the diagnosis of rotator cuff tears when performed exclusively at 3-T. A systematic review was undertaken of the Cochrane, MEDLINE and PubMed databases in accordance with the PRISMA guidelines. Studies comparing 3-T MRI or 3-T MRA (index tests) to arthroscopic surgical findings (reference test) were included. Methodological appraisal was performed using QUADAS 2. Pooled sensitivity and specificity were calculated and summary receiver-operating curves generated. Kappa coefficients quantified inter-observer reliability. Fourteen studies comprising 1332 patients were identified for inclusion. Twelve studies were retrospective and there were concerns regarding index test bias and applicability in nine and six studies respectively. Reference test bias was a concern in all studies. Both 3-T MRI and 3-T MRA showed similar excellent diagnostic accuracy for full-thickness supraspinatus tears. Concerning partial-thickness supraspinatus tears, 3-T 2D MRA was significantly more sensitive (86.6 vs. 80.5 %, p = 0.014) but significantly less specific (95.2 vs. 100 %, p < 0.001). There was a trend towards greater accuracy in the diagnosis of subscapularis tears with 3-T MRA. Three-Tesla 3D isotropic MRA showed similar accuracy to 3-T conventional 2D MRA. Three-Tesla MRI appeared equivalent to 3-T MRA in the diagnosis of full- and partial-thickness tears, although there was a trend towards greater accuracy in the diagnosis of subscapularis tears with 3-T MRA. Three-Tesla 3D isotropic MRA appears equivalent to 3-T 2D MRA for all types of tears. (orig.)

  12. Diagnosis of rotator cuff tears using 3-Tesla MRI versus 3-Tesla MRA: a systematic review and meta-analysis

    International Nuclear Information System (INIS)

    McGarvey, Ciaran; Harb, Ziad; Smith, Christian; Ajuied, Adil; Houghton, Russell; Corbett, Steven

    2016-01-01

    To compare the diagnostic accuracy of magnetic resonance imaging (MRI), 2-dimensional magnetic resonance arthrogram (MRA) and 3-dimensional isotropic MRA in the diagnosis of rotator cuff tears when performed exclusively at 3-T. A systematic review was undertaken of the Cochrane, MEDLINE and PubMed databases in accordance with the PRISMA guidelines. Studies comparing 3-T MRI or 3-T MRA (index tests) to arthroscopic surgical findings (reference test) were included. Methodological appraisal was performed using QUADAS 2. Pooled sensitivity and specificity were calculated and summary receiver-operating curves generated. Kappa coefficients quantified inter-observer reliability. Fourteen studies comprising 1332 patients were identified for inclusion. Twelve studies were retrospective and there were concerns regarding index test bias and applicability in nine and six studies respectively. Reference test bias was a concern in all studies. Both 3-T MRI and 3-T MRA showed similar excellent diagnostic accuracy for full-thickness supraspinatus tears. Concerning partial-thickness supraspinatus tears, 3-T 2D MRA was significantly more sensitive (86.6 vs. 80.5 %, p = 0.014) but significantly less specific (95.2 vs. 100 %, p < 0.001). There was a trend towards greater accuracy in the diagnosis of subscapularis tears with 3-T MRA. Three-Tesla 3D isotropic MRA showed similar accuracy to 3-T conventional 2D MRA. Three-Tesla MRI appeared equivalent to 3-T MRA in the diagnosis of full- and partial-thickness tears, although there was a trend towards greater accuracy in the diagnosis of subscapularis tears with 3-T MRA. Three-Tesla 3D isotropic MRA appears equivalent to 3-T 2D MRA for all types of tears. (orig.)

  13. Diagnosis of rotator cuff tears using 3-Tesla MRI versus 3-Tesla MRA: a systematic review and meta-analysis.

    Science.gov (United States)

    McGarvey, Ciaran; Harb, Ziad; Smith, Christian; Houghton, Russell; Corbett, Steven; Ajuied, Adil

    2016-02-01

    To compare the diagnostic accuracy of magnetic resonance imaging (MRI), 2-dimensional magnetic resonance arthrogram (MRA) and 3-dimensional isotropic MRA in the diagnosis of rotator cuff tears when performed exclusively at 3-T. A systematic review was undertaken of the Cochrane, MEDLINE and PubMed databases in accordance with the PRISMA guidelines. Studies comparing 3-T MRI or 3-T MRA (index tests) to arthroscopic surgical findings (reference test) were included. Methodological appraisal was performed using QUADAS 2. Pooled sensitivity and specificity were calculated and summary receiver-operating curves generated. Kappa coefficients quantified inter-observer reliability. Fourteen studies comprising 1332 patients were identified for inclusion. Twelve studies were retrospective and there were concerns regarding index test bias and applicability in nine and six studies respectively. Reference test bias was a concern in all studies. Both 3-T MRI and 3-T MRA showed similar excellent diagnostic accuracy for full-thickness supraspinatus tears. Concerning partial-thickness supraspinatus tears, 3-T 2D MRA was significantly more sensitive (86.6 vs. 80.5 %, p = 0.014) but significantly less specific (95.2 vs. 100 %, p Tesla 3D isotropic MRA showed similar accuracy to 3-T conventional 2D MRA. Three-Tesla MRI appeared equivalent to 3-T MRA in the diagnosis of full- and partial-thickness tears, although there was a trend towards greater accuracy in the diagnosis of subscapularis tears with 3-T MRA. Three-Tesla 3D isotropic MRA appears equivalent to 3-T 2D MRA for all types of tears.

  14. Cavity parameters identification for TESLA control system development

    Energy Technology Data Exchange (ETDEWEB)

    Czarski, T.; Pozniak, K.T.; Romaniuk, R.S. [Warsaw Univ. of Technology (Poland). ELHEP Lab., ISE; Simrock, S. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2005-07-01

    The control system modeling for the TESLA - TeV-Energy Superconducting Linear Accelerator project has been developed for the efficient stabilization of the pulsed, accelerating EM field of the resonator. The cavity parameters identification is an essential task for the comprehensive control algorithm. The TESLA cavity simulator has been successfully implemented by applying very high speed FPGA - Field Programmable Gate Array technology. The electromechanical model of the cavity resonator includes the basic features - Lorentz force detuning and beam loading. The parameters identification bases on the electrical model of the cavity. The model is represented by the state space equation for the envelope of the cavity voltage driven by the current generator and the beam loading. For a given model structure, the over-determined matrix equation is created covering the long enough measurement range with the solution according to the least squares method. A low degree polynomial approximation is applied to estimate the time-varying cavity detuning during the pulse. The measurement channel distortion is considered, leading to the external cavity model seen by the controller. The comprehensive algorithm of the cavity parameters identification has been implemented in the Matlab system with different modes of the operation. Some experimental results have been presented for different cavity operational conditions. The following considerations have lead to the synthesis of the efficient algorithm for the cavity control system predicted for the potential FPGA technology implementation. (orig.)

  15. Cavity parameters identification for TESLA control system development

    International Nuclear Information System (INIS)

    Czarski, T.; Pozniak, K.T.; Romaniuk, R.S.

    2005-01-01

    The control system modeling for the TESLA - TeV-Energy Superconducting Linear Accelerator project has been developed for the efficient stabilization of the pulsed, accelerating EM field of the resonator. The cavity parameters identification is an essential task for the comprehensive control algorithm. The TESLA cavity simulator has been successfully implemented by applying very high speed FPGA - Field Programmable Gate Array technology. The electromechanical model of the cavity resonator includes the basic features - Lorentz force detuning and beam loading. The parameters identification bases on the electrical model of the cavity. The model is represented by the state space equation for the envelope of the cavity voltage driven by the current generator and the beam loading. For a given model structure, the over-determined matrix equation is created covering the long enough measurement range with the solution according to the least squares method. A low degree polynomial approximation is applied to estimate the time-varying cavity detuning during the pulse. The measurement channel distortion is considered, leading to the external cavity model seen by the controller. The comprehensive algorithm of the cavity parameters identification has been implemented in the Matlab system with different modes of the operation. Some experimental results have been presented for different cavity operational conditions. The following considerations have lead to the synthesis of the efficient algorithm for the cavity control system predicted for the potential FPGA technology implementation. (orig.)

  16. Experimental program with beam in TESLA test facility

    International Nuclear Information System (INIS)

    Mosnier, A.; Aune, B.

    1994-09-01

    In order to establish a technical basis for a high energy e + e - collider using the superconducting RF technology, the test of a string of 32 cavities with beam at an accelerating gradient of 15 MV/m is planned in an installation at DESY. Several experiments with beam in the TTF linac will be performed. The dissipated HOM power at helium temperature is a key issue for TESLA, its estimation requires careful calorimetric measurements and the full charge injector. Bunch wake potentials can be estimated with bunch charges of at least 1 to 2 nC. Multibunch measurements require a beam of a few hundreds of these bunches. The beam will be injected either on axis or off axis. RF steering due to couplers will be estimated by measuring the beam displacement for different RF phase settings. The expected resolution is well below the TESLA specification. The acceleration of dark currents will be observed for different settings of the focusing elements. 7 figs., 1 tab., 3 refs

  17. First signal from a broadband cryogenic preamplifier cooled by circulating liquid nitrogen in a 7 T Fourier transform ion cyclotron resonance mass spectrometer.

    Science.gov (United States)

    Choi, Myoung Choul; Lee, Jeong Min; Lee, Se Gyu; Choi, Sang Hwan; Choi, Yeon Suk; Lee, Kyung Jae; Kim, SeungYong; Kim, Hyun Sik; Stahl, Stefan

    2012-12-18

    Despite the outstanding performance of Fourier transform ion cyclotron/mass spectrometry (FTICR/MS), the complexity of the cellular proteome or natural compounds presents considerable challenges. Sensitivity is a key performance parameter of a FTICR mass spectrometer. By improving this parameter, the dynamic range of the instrument can be increased to improve the detection signal of low-abundance compounds or fragment ion peaks. In order to improve sensitivity, a cryogenic detection system was developed by the KBSI (Korean Basic Science Institute) in collaboration with Stahl-Electronics (Mettenheim, Germany). A simple, efficient liquid circulation cooling system was designed and a cryogenic preamplifier implemented inside a FTICR mass spectrometer. This cooling system circulates a cryoliquid from a Dewar to the "liquid circulation unit" through a CF flange to cool a copper block and a cryopreamplifier; the cooling medium is subsequently exhausted into the air. The cryopreamplifier can be operated over a very wide temperature range, from room temperature to low temperature environments (4.2 K). First, ion signals detected by the cryopreamplifier using a circulating liquid nitrogen cooling system were observed and showed a signal-to-noise ratio (S/N) about 130% better than that obtained at room temperature.

  18. Performance estimation of Tesla turbine applied in small scale Organic Rankine Cycle (ORC) system

    International Nuclear Information System (INIS)

    Song, Jian; Gu, Chun-wei; Li, Xue-song

    2017-01-01

    Highlights: • One-dimensional model of the Tesla turbine is improved and applied in ORC system. • Working fluid properties and system operating conditions impact efficiency. • The influence of turbine efficiency on ORC system performance is evaluated. • Potential of using Tesla turbine in ORC systems is estimated. - Abstract: Organic Rankine Cycle (ORC) system has been proven to be an effective method for the low grade energy utilization. In small scale applications, the Tesla turbine offers an attractive option for the organic expander if an efficient design can be achieved. The Tesla turbine is simple in structure and is easy to be manufactured. This paper improves the one-dimensional model for the Tesla turbine, which adopts a non-dimensional formulation that identifies the dimensionless parameters that dictates the performance features of the turbine. The model is used to predict the efficiency of a Tesla turbine that is applied in a small scale ORC system. The influence of the working fluid properties and the operating conditions on the turbine performance is evaluated. Thermodynamic analysis of the ORC system with different organic working fluids and under various operating conditions is conducted. The simulation results reveal that the ORC system can generate a considerable net power output. Therefore, the Tesla turbine can be regarded as a potential choice to be applied in small scale ORC systems.

  19. EQUACIONAMENTO E MODELAGEM DA BOBINA BIFILAR DE TESLA

    Directory of Open Access Journals (Sweden)

    Caio Marcelo de Marcelo de Miranda

    2012-01-01

    Full Text Available A Biotelemetria apresenta-se como uma importante técnica que possui várias aplicações na área de Biomedicina e outras. A dimensão da unidade remota ou sensora constitui um grande desafio dentro desta área, sendo que na maioria dos casos,deseja-se uma unidade o menor possível. Desta maneira, sensores passivos são interessantes, pois possibilitam uma menor dimensão do dispositivo e não necessitam de uma fonte própria de energia, ou bateria, que pode causar danos ao indivíduo monitorado caso ocorra vazamento do seu conteúdo químico. Deste modo,o sensor indutivo autorressonante apresenta-se como uma boa solução, uma vez que este pode ser construído com apenas um componente, neste caso um indutor.Por apresentar pequenas dimensões, este tipo de sensor possui uma baixa capacitância parasita, o que torna a sua frequência de ressonância bastante alta. Neste caso, a bobina bifilar idealizada por Nikola Tesla pode constituir-se de uma solução, uma vez que a idéia de Tesla era de aumentar a capacitância intrínseca de suas bobinas. Portanto, um entendimento físico e devido equacionamento da bobina bifilar se faz necessário, uma vez que, até onde se sabe, este tipo de abordagem não existe na literatura.A partir de uma análise das tensões entre espiras adjacentes, foi desenvolvido neste trabalho um equacionamento da bobina bifilar de Tesla, possibilitando a determinação do aumento da capacitância interna e, consequente, redução na frequência de ressonância desta bobina. Um modelo elétrico equivalente da bobina foi também elaborado através desta análise. Isto possibilita o projeto de bobinas bifilares e predição dos parâmetros capacitância e frequência de autorressonância desta bobina. Testes foram realizados ao comparar a frequência de autorressonância calculada e medida para diversos números de espiras,comprovando a validade do modelo e das equações desenvolvidas.

  20. Analysis of impact of temperature and saltwater on Nannochloropsis salina bio-oil production by ultra high resolution APCI FT-ICR MS

    KAUST Repository

    Sanguineti, Michael Mario

    2015-05-01

    Concentrated Nannochloropsis salina paste was reconstituted in distilled water and synthetic saltwater and processed at 250°C and 300°C via hydrothermal liquefaction. The resulting bio-oils yielded a diverse distribution of product classes, as analyzed by ultra high resolution APCI FT-ICR MS. The organic fractions were analyzed and both higher temperatures and distilled water significantly increase the number of total compounds present and the number of product classes. Major bio-oil products consisted of N1O1, hydrocarbon, and O2 classes, while O1, O4, S1, N1O2, and N2O2 classes represented the more significant minor classes. Both chlorine and sulfur containing compounds were detected in both distilled and saltwater reactions, while fewer numbers of chlorine and sulfur containing products were present in the organic fraction of the saltwater reactions. Further refinement to remove the chlorine and sulfur contents appears necessary with marine microalgal bio-oils produced via hydrothermal liquefaction. The higher heating value (MJ/kg) as calculated by the Boie equation of classes of interest in the bio-oil reveals a significant potential of algal hydrothermal liquefaction products as a sustainable and renewable fuel feedstock. © 2015.

  1. Status and outlook for high power processing of 1.3 GHz TESLA multicell cavities

    International Nuclear Information System (INIS)

    Kirchgessner, J.; Barnes, P.; Graber, J.; Metzger, D.; Mofat, D.; Muller, H.; Padamsee, H.; Sears, J.; Tigner, M.; Matheisen, A.

    1993-01-01

    In order to increase the usable accelerating gradient in Superconducting TESLA cavities, the field emission threshold barrier must be raised. As has been previously demonstrated on S-band cavities, a way to accomplish this is with the use of high peak power RF processing. A transmitter with a peak power of 2 Mwatt and 300 μsec pulse length has been assembled and has been used to process TESLA cavities. Several five cell TESLA cavities at 1.3 GHz have been manufactured for this purpose. This transmitter and the cavities will be described and the results of the tests will be presented

  2. Nikola Tesla and medicine: 160th anniversary of the birth of the genius who gave light to the world - Part II

    OpenAIRE

    Vučević, Danijela; Đorđević, Drago; Radosavljević, Tatjana

    2016-01-01

    Introduction. Nikola Tesla (1856 - 1943) was a genius inventor and scientist, whose contribution to medicine is remarkable. Part I of this article reviewed special contributions of the world renowned scientist to the establishment of radiology as a new discipline in medicine. This paper deals with the use of Tesla currents in medicine. Tesla Currents in Medicine. Tesla's greatest impact on medicine is his invention of a transformer (Tesla coil) for producing high frequency and high voltage cu...

  3. A database for superconducting cavities for the TESLA Test Facility

    International Nuclear Information System (INIS)

    Gall, P.D.; Goessel, A.; Gubarev, V.; Iversen, J.

    2006-01-01

    We look back on 10 years experience using a database for superconducting cavities for the TESLA Test Facility (TTF). The database was developed to collect data of every preparation step and measurement in order to optimize cavity production and preparation techniques to meet the ambitious goal of high accelerating gradients at high quality factors. Data from 110 superconducting 9-cell cavities, 50 single cell cavities, several 2- to 7-cell cavities and about 60 RF couplers were collected in the database. In addition, company measurements on sub-assemblies and parts forming the next 30 9-cell cavities were stored, thus establishing the database as part of a quality management system. This database is dynamically accessible via an extensive graphical web-interface based on ORACLE products, which enables the users to select and analyse the collected data easily from anywhere

  4. Report on the TESLA engineering study/review

    Energy Technology Data Exchange (ETDEWEB)

    C. Boffo et al.

    2002-07-18

    A team from Argonne National Lab, Cornell, Fermilab, Jefferson Lab, and SLAC has studied the TESLA TDR and its associated cost and manpower estimates, concentrating on the five largest cost sub-systems (Main Linac Modules, Main Linac RF Systems, Civil Engineering, Machine Infrastructure, and XFEL Incremental). These elements were concerned mainly with providing energy reach. We did not study the lower cost, but still technically challenging elements providing luminosity and physics capability, namely damping rings, beam delivery system, beam injection system, positron production, polarized beams, etc. The study did not attempt to validate the TDR cost estimates, but rather its purpose was to understand the technology and status of the large cost items, and the methodology by which their estimated cost was determined. In addition, topics of project oversight were studied.

  5. 3-Tesla MRI: Beneficial visualization of the meniscofemoral ligaments?

    Science.gov (United States)

    Ebrecht, Johanna; Krasny, Andrej; Hartmann, Dinah Maria; Rückbeil, Marcia Viviane; Ritz, Thomas; Prescher, Andreas

    2017-10-01

    Recent investigations have confirmed an important stabilizing and protective function of the meniscofemoral ligaments (MFLs) to the knee joint and suggest a clinical relevance. Concerning their incidences, however, there have been discrepancies between data acquired from cadaveric studies and MRI data using 0.3- to 1.5-Tesla field strengths probably due to lower resolution. This study aims to investigate whether imaging with 3-Tesla magnetic resonance imaging (3-T MRI) is beneficial in gaining information regarding the ligaments' incidence, length, width and anatomic variation. 3-T MRI images of 448 patients (224 males, 224 females, with, respectively, 32 patients of each sex in the age groups: 0-20, 21-30, 31-40, 41-50, 51-60, 61-70, >70years) were retrospectively reviewed. The influence of the parameters 'sex' and 'age' was determined. Whereas 71% of the patients had at least one MFL, 22% had an anterior MFL (aMFL), 53% had a posterior MFL (pMFL) and five percent had coexisting ligaments. The pMFLs were more likely to be present in female patients (P<0.05) but if so, they were longer in the males (P<0.05). The pMFL was categorized according to its insertion on the medial femoral condyle. 3-T MRI enables an excellent illustration of the anatomic variations of pMFLs. By modifying an anatomic classification for radiological use we measured lengths and widths of the MFLs without any difficulties. Despite its increased resolution, 3-T MRI lends no diagnostic benefit in visualizing the course of the aMFL or filigree coexisting ligaments as compared to MRI at lower field strengths. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

    Science.gov (United States)

    Li, Huilin; Nguyen, Hong Hanh; Ogorzalek Loo, Rachel R.; Campuzano, Iain D. G.; Loo, Joseph A.

    2018-02-01

    Mass spectrometry (MS) has become a crucial technique for the analysis of protein complexes. Native MS has traditionally examined protein subunit arrangements, while proteomics MS has focused on sequence identification. These two techniques are usually performed separately without taking advantage of the synergies between them. Here we describe the development of an integrated native MS and top-down proteomics method using Fourier-transform ion cyclotron resonance (FTICR) to analyse macromolecular protein complexes in a single experiment. We address previous concerns of employing FTICR MS to measure large macromolecular complexes by demonstrating the detection of complexes up to 1.8 MDa, and we demonstrate the efficacy of this technique for direct acquirement of sequence to higher-order structural information with several large complexes. We then summarize the unique functionalities of different activation/dissociation techniques. The platform expands the ability of MS to integrate proteomics and structural biology to provide insights into protein structure, function and regulation.

  7. Gadolinium-based magnetic resonance contrast agents at 7 Tesla: in vitro T1 relaxivities in human blood plasma.

    Science.gov (United States)

    Noebauer-Huhmann, Iris M; Szomolanyi, Pavol; Juras, Vladimír; Kraff, Oliver; Ladd, Mark E; Trattnig, Siegfried

    2010-09-01

    PURPOSE/INTRODUCTION: The aim of this study was to determine the T1 relaxivities (r1) of 8 gadolinium (Gd)-based MR contrast agents in human blood plasma at 7 Tesla, compared with 3 Tesla. Eight commercially available Gd-based MR contrast agents were diluted in human blood plasma to concentrations of 0, 0.25, 0.5, 1, and 2 mmol/L. In vitro measurements were performed at 37 degrees C, on a 7 Tesla and on a 3 Tesla whole-body magnetic resonance imaging scanner. For the determination of T1 relaxation times, Inversion Recovery Sequences with inversion times from 0 to 3500 ms were used. The relaxivities were calculated. The r1 relaxivities of all agents, diluted in human blood plasma at body temperature, were lower at 7 Tesla than at 3 Tesla. The values at 3 Tesla were comparable to those published earlier. Notably, in some agents, a minor negative correlation of r1 with a concentration of up to 2 mmol/L could be observed. This was most pronounced in the agents with the highest protein-binding capacity. At 7 Tesla, the in vitro r1 relaxivities of Gd-based contrast agents in human blood plasma are lower than those at 3 Tesla. This work may serve as a basis for the application of Gd-based MR contrast agents at 7 Tesla. Further studies are required to optimize the contrast agent dose in vivo.

  8. Two-Layer 16 Tesla Cosθ Dipole Design for the FCC

    Energy Technology Data Exchange (ETDEWEB)

    Holik, Eddie Frank [Fermilab; Ambrosio, Giorgio [Fermilab; Apollinari, G. [Fermilab

    2018-02-13

    The Future Circular Collider or FCC is a study aimed at exploring the possibility to reach 100 TeV total collision energy which would require 16 tesla dipoles. Upon the conclusion of the High Luminosity Upgrade, the US LHC Accelerator Upgrade Pro-ject in collaboration with CERN will have extensive Nb3Sn magnet fabrication experience. This experience includes robust Nb3Sn conductor and insulation scheming, 2-layer cos2θ coil fabrication, and bladder-and-key structure and assembly. By making im-provements and modification to existing technology the feasibility of a two-layer 16 tesla dipole is investigated. Preliminary designs indicate that fields up to 16.6 tesla are feasible with conductor grading while satisfying the HE-LHC and FCC specifications. Key challenges include accommodating high-aspect ratio conductor, narrow wedge design, Nb3Sn conductor grading, and especially quench protection of a 16 tesla device.

  9. Large-Signal Code TESLA: Improvements in the Implementation and in the Model

    National Research Council Canada - National Science Library

    Chernyavskiy, Igor A; Vlasov, Alexander N; Anderson, Jr., Thomas M; Cooke, Simon J; Levush, Baruch; Nguyen, Khanh T

    2006-01-01

    We describe the latest improvements made in the large-signal code TESLA, which include transformation of the code to a Fortran-90/95 version with dynamical memory allocation and extension of the model...

  10. 4 Tesla Whole Body MRI MRSI System for Investigation of Neurodegenerative Diseases

    National Research Council Canada - National Science Library

    Weiner, Michael W

    2004-01-01

    The overall long-term goal of imaging research to be performed with this 4 Tesla Siemens/Bruker MRI system is the development of improved diagnostic methods for accurate detection of neurodegenerative...

  11. Application of phase correction to improve the interpretation of crude oil spectra obtained using 7 T Fourier transform ion cyclotron resonance mass spectrometry.

    Science.gov (United States)

    Cho, Yunju; Qi, Yulin; O'Connor, Peter B; Barrow, Mark P; Kim, Sunghwan

    2014-01-01

    In this study, a phase-correction technique was applied to the study of crude oil spectra obtained using a 7 T Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). 7 T FT-ICR MS had not been widely used for oil analysis due to the lower resolving power compared with high field FT-ICR MS. For low field instruments, usage of data that has not been phase-corrected results in an inability to resolve critical mass splits of C3 and SH4 (3.4 mDa), and (13)C and CH (4.5 mDa). This results in incorrect assignments of molecular formulae, and discontinuous double bond equivalents (DBE) and carbon number distributions of S1, S2, and hydrocarbon classes are obtained. Application of phase correction to the same data, however, improves the reliability of assignments and produces continuous DBE and carbon number distributions. Therefore, this study clearly demonstrates that phase correction improves data analysis and the reliability of assignments of molecular formulae in crude oil anlayses.

  12. Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: implications for IgA nephropathy

    DEFF Research Database (Denmark)

    Renfrow, MB; Mackay, CL; Chalmers, MJ

    2007-01-01

    deficiency in IgA1 proteins occurs randomly or preferentially at specific sites. We have previously demonstrated the first direct localization of multiple O-glycosylation sites on a single IgA1 myeloma protein by use of activated ion-electron capture dissociation (AI-ECD) Fourier transform ion cyclotron...... resonance (FT-ICR) tandem mass spectrometry. Here, we report the analysis of IgA1 O-glycan heterogeneity by use of FT-ICR MS and liquid chromatography FT-ICR MS to obtain unbiased accurate mass profiles of IgA1 HR glycopeptides from three different IgA1 myeloma proteins. Additionally, we report the first AI......-ECD fragmentation on an individual IgA1 O-glycopeptide from an IgA1 HR preparation that is reproducible for each IgA1 myeloma protein. These results suggest that future analysis of IgA1 HR from IgAN patients and normal healthy controls should be feasible....

  13. Beamstrahlung Photon Load on the TESLA Extraction Septum Blade(LCC-0104)

    Energy Technology Data Exchange (ETDEWEB)

    Seryi, A

    2003-10-02

    This note describes work performed in the framework of the International Linear Collider Technical Review Committee [1] to estimate the power load on the TESLA extraction septum blade due to beamstrahlung photons. It is shown, that under realistic conditions the photon load can be several orders of magnitude higher than what was estimated in the TESLA TDR [2] for the ideal Gaussian beams, potentially representing a serious limitation of the current design.

  14. First cold test of TESLA superconducting RF cavity in horizontal cryostat (CHECHIA)

    International Nuclear Information System (INIS)

    Kuzminski, J.

    1996-01-01

    In the framework of the TESLA project, the horizontal cryostat (CHECHIA) was built to test a superconducting RF cavity equipped with its helium vessel, magnetic shielding, cold tuner, main coupler and higher order modes couplers under realistic conditions before final assembly of eight cavities into TESLA Test Facility cryo-module. The results of the first cold tests in CHECHIA, performed at DESY with a 9-cell cavity (C19) to be used in the TTF injector are presented. (author)

  15. Beamstrahlung Photon Load on the TESLA Extraction Septum Blade(LCC-0104)

    International Nuclear Information System (INIS)

    Seryi, A

    2003-01-01

    This note describes work performed in the framework of the International Linear Collider Technical Review Committee [1] to estimate the power load on the TESLA extraction septum blade due to beamstrahlung photons. It is shown, that under realistic conditions the photon load can be several orders of magnitude higher than what was estimated in the TESLA TDR [2] for the ideal Gaussian beams, potentially representing a serious limitation of the current design

  16. MEASUREMENT OF THE TRANSVERSE BEAM DYNAMICS IN A TESLA-TYPE SUPERCONDUCTING CAVITY

    Energy Technology Data Exchange (ETDEWEB)

    Halavanau, A. [NICADD, DeKalb; Eddy, N. [Fermilab; Edstrom, D. [Fermilab; Lunin, A. [Fermilab; Piot, P. [NICADD, DeKalb; Ruan, J. [Fermilab; Solyak, N. [Fermilab

    2016-09-26

    Superconducting linacs are capable of producing intense, ultra-stable, high-quality electron beams that have widespread applications in Science and Industry. Many project are based on the 1.3-GHz TESLA-type superconducting cavity. In this paper we provide an update on a recent experiment aimed at measuring the transfer matrix of a TESLA cavity at the Fermilab Accelerator Science and Technology (FAST) facility. The results are discussed and compared with analytical and numerical simulations.

  17. Off Like a Rocket: A Media Discourse Analysis of Tesla Motor Corporation

    OpenAIRE

    McKay, Jordan

    2016-01-01

    Energy and transportation are topics of great importance to global sustainable development.  Tesla Motor Corporation is an electric vehicle company with the objective to “accelerate the world’s transition to sustainable energy” (Musk, 2016).  This thesis, a media discourse analysis, examines media texts concerning Tesla Motors to provide a better understanding of the company’s hitherto success in penetrating the automotive market.  Qualitative analyses of text were utilized to first define th...

  18. In vivo high-resolution 7 Tesla MRI shows early and diffuse cortical alterations in CADASIL.

    Directory of Open Access Journals (Sweden)

    François De Guio

    Full Text Available Recent data suggest that early symptoms may be related to cortex alterations in CADASIL (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, a monogenic model of cerebral small vessel disease (SVD. The aim of this study was to investigate cortical alterations using both high-resolution T2* acquisitions obtained with 7 Tesla MRI and structural T1 images with 3 Tesla MRI in CADASIL patients with no or only mild symptomatology (modified Rankin's scale ≤1 and Mini Mental State Examination (MMSE ≥24.Complete reconstructions of the cortex using 7 Tesla T2* acquisitions with 0.7 mm isotropic resolution were obtained in 11 patients (52.1±13.2 years, 36% male and 24 controls (54.8±11.0 years, 42% male. Seven Tesla T2* within the cortex and cortical thickness and morphology obtained from 3 Tesla images were compared between CADASIL and control subjects using general linear models.MMSE, brain volume, cortical thickness and global sulcal morphology did not differ between groups. By contrast, T2* measured by 7 Tesla MRI was significantly increased in frontal, parietal, occipital and cingulate cortices in patients after correction for multiple testing. These changes were not related to white matter lesions, lacunes or microhemorrhages in patients having no brain atrophy compared to controls.Seven Tesla MRI, by contrast to state of the art post-processing of 3 Tesla acquisitions, shows diffuse T2* alterations within the cortical mantle in CADASIL whose origin remains to be determined.

  19. Cervical external immobilization devices: evaluation of magnetic resonance imaging issues at 3.0 Tesla.

    Science.gov (United States)

    Diaz, Francis L; Tweardy, Lisa; Shellock, Frank G

    2010-02-15

    Laboratory investigation, ex vivo. Currently, no studies have addressed the magnetic resonance imaging (MRI) issues for cervical external immobilization devices at 3-Tesla. Under certain conditions significant heating may occur, resulting in patient burns. Furthermore, artifacts can be substantial and prevent the diagnostic use of MRI. Therefore, the objective of this investigation was to evaluate MRI issues for 4 different cervical external immobilization devices at 3-Tesla. Excessive heating and substantial artifacts are 2 potential complications associated with performing MRI at 3-Tesla in patients with cervical external immobilization devices. Using ex vivo testing techniques, MRI-related heating and artifacts were evaluated for 4 different cervical devices during MRI at 3-Tesla. Four cervical external immobilization devices (Generation 80, Resolve Ring and Superstructure, Resolve Ring and Jerome Vest/Jerome Superstructure, and the V1 Halo System; Ossur Americas, Aliso Viejo, CA) underwent MRI testing at 3-Tesla. All devices were made from nonmetallic or nonmagnetic materials. Heating was determined using a gelled-saline-filled skull phantom with fluoroptic thermometry probes attached to the skull pins. MRI was performed at 3-Tesla, using a high level of RF energy. Artifacts were assessed at 3-Tesla, using standard cervical imaging techniques. The Generation 80 and V1 Halo devices exhibited substantial temperature rises (11.6 degrees C and 8.5 degrees C, respectively), with "sparking" evident for the Generation 80 during the MRI procedure. Artifacts were problematic for these devices, as well. By comparison, the 2 Resolve Ring-based cervical external immobilization devices showed little or no heating (Tesla.

  20. NIKOLA TESLA AND MEDICINE: 160TH ANNIVERSARY OF THE BIRTH OF THE GENIUS WHO GAVE LIGHT TO THE WORLD - PART II.

    Science.gov (United States)

    Vucevic, Danijela; Dordevic, Drago; Radosavljevic, Tatjana

    2016-11-01

    Nikola Tesla (1856- 1943) was a genius inventor and scientist, whose contribution to medicine is remarkable. Part I of this article reviewed special contributions of the world renowned scientist to the establishment of radiology as a new discipline in medicine. This paper deals with the use of Tesla currents in medicine. Tesla Currents in Medicine. Tesla's greatest impact on medicine is his invention of a transformer (Tesla coil) for producing high frequency and high voltage currents (Tesla currents). Tesla currents are used in diathermy, as they, while passing through the body, transform electrical energy into a therapeutic heat. In 1891, Tesla passed currents through his own body and was the first to experience their beneficial effects. He kept correspondence on electrotherapy with J. Dugan and S. H. Monell. In 1896, he used high frequency currents and designed an ozone generator for producing ozone, with powerful antiseptic and antibacterial properties. Tesla is famous for his extensive experiments with mechanical vibrations and resonance, examining their effects on the organ ism and pioneering their use for medical purposes. Tesla also designed an oscillator to relieve fatigue of the leg muscles. It is less known that Tesla's inventions (Tesla coil and wireless remote control) are widely used in modern medical equipment. Apart from this, wireless technology is nowadays widely applied in numerous diagnostic and therapeutic procedures. Nikola Tesla was the last Renais- sance figure of the modern era. Tesla bridged three centuries and two millennia by his inventions, and permanently indebted humankind by his epochal discoveries.

  1. Theory of peak coalescence in Fourier transform ion cyclotron resonance mass spectrometry.

    Science.gov (United States)

    Boldin, Ivan A; Nikolaev, Eugene N

    2009-10-01

    Peak coalescence, i.e. the merging of two close peaks in a Fourier transform ion cyclotron resonance (FTICR) mass spectrum at a high number of ions, plays an important role in various FTICR experiments. In order to describe the coalescence phenomenon we would like to propose a new theory of motion for ion clouds with close mass-to-charge ratios, driven by a uniform magnetic field and Coulomb interactions between the clouds. We describe the motion of the ion clouds in terms of their averaged drift motion in crossed magnetic and electric fields. The ion clouds are considered to be of constant size and their motion is studied in two dimensions. The theory deals with the first-order approximation of the equations of motion in relation to dm/m, where dm is the mass difference and m is the mass of a single ion. The analysis was done for an arbitrary inter-cloud interaction potential, which makes it possible to analyze finite-size ion clouds of any shape. The final analytical expression for the condition of the onset of coalescence is found for the case of uniformly charged spheres. An algorithm for finding this condition for an arbitrary interaction potential is proposed. The critical number of ions for the peak coalescence to take place is shown to depend quadratically on the magnetic field strength and to be proportional to the cyclotron radius and inversely proportional to the ion masses. Copyright (c) 2009 John Wiley & Sons, Ltd.

  2. Dobutamine stress cardiovascular magnetic resonance at 3 Tesla

    Directory of Open Access Journals (Sweden)

    Klein C

    2008-10-01

    Full Text Available Abstract Purpose The assessment of inducible wall motion abnormalities during high-dose dobutamine-stress cardiovascular magnetic resonance (DCMR is well established for the identification of myocardial ischemia at 1.5 Tesla. Its feasibility at higher field strengths has not been reported. The present study was performed to prospectively determine the feasibility and diagnostic accuracy of DCMR at 3 Tesla for depicting hemodynamically significant coronary artery stenosis (≥ 50% diameter stenosis in patients with suspected or known coronary artery disease (CAD. Materials and methods Thirty consecutive patients (6 women (66 ± 9.3 years were scheduled for DCMR between January and May 2007 for detection of coronary artery disease. Patients were examined with a Philips Achieva 3 Tesla system (Philips Healthcare, Best, The Netherlands, using a spoiled gradient echo cine sequence. Technical parameters were: spatial resolution 2 × 2 × 8 mm3, 30 heart phases, spoiled gradient echo TR/TE: 4.5/2.6 msec, flip angle 15°. Images were acquired at rest and stress in accordance with a standardized high-dose dobutamine-atropine protocol during short breath-holds in three short and three long-axis views. Dobutamine was administered using a standard protocol (10 μg increments every 3 minutes up to 40 μg dobutamine/kg body weight/minute plus atropine if required to reach target heart rate. The study protocol included administration of 0.1 mmol/kg/body weight Gd-DTPA before the cine images at rest were acquired to improve the image quality. The examination was terminated if new or worsening wall-motion abnormalities or chest pain occurred or when > 85% of age-predicted maximum heart rate was reached. Myocardial ischemia was defined as new onset of wall-motion abnormality in at least one segment. In addition, late gadolinium enhancement (LGE was performed. Images were evaluated by two blinded readers. Diagnostic accuracy was determined with coronary

  3. Extension of the analytical window for characterizing aromatic compounds in oils using a comprehensive suite of high-resolution mass spectrometry techniques and double bond equivalence versus carbon number plot

    Science.gov (United States)

    Cho, Yunju; Birdwell, Justin E.; Hur, Manhoi; Lee, Joonhee; Kim, Byungjoo; Kim, Sunghwan

    2017-01-01

    In this study, comprehensive two-dimensional (2D) gas chromatography–mass spectrometry (GC–MS), atmospheric pressure photoionization (APPI) quadrupole-Orbitrap mass spectrometry (MS), and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) were used to study the aromatic fractions of crude oil and oil shale pyrolysates (shale oils). The collected data were compared and combined in the double bond equivalence (DBE) versus carbon number plot to obtain a more complete understanding of the composition of the oil fractions. The numbers of peaks observed by each technique followed the order 2D GC–MS plots of DBE and carbon number showed an extended range of higher values relative to the other methods. For the aromatic fraction of an oil shale pyrolysate generated by the Fischer assay, only a few nitrogen-containing compounds were observed by 2D GC–MS but a large number of these compounds were detected by Orbitrap MS and FT-ICR MS. This comparison clearly shows that the data obtained from these three techniques can be combined to more completely characterize oil composition. The data obtained by Orbitrap MS and FT-ICR MS agreed well with one another, and the combined DBE versus carbon number plot provided more complete coverage of compounds present in the fractions. In addition, the chemical structure information provided by 2D GC–MS could be matched with the chemical formulas in the DBE versus carbon number plots, providing information not available in ultrahigh-resolution MS results. It was therefore concluded that the combination of 2D GC–MS, Orbitrap MS, and FT-ICR MS in the DBE versus carbon number space facilitates structural assignment of heavy oil components.

  4. [Examination of upper abdominal region in high spatial resolution diffusion-weighted imaging using 3-Tesla MRI].

    Science.gov (United States)

    Terada, Masaki; Matsushita, Hiroki; Oosugi, Masanori; Inoue, Kazuyasu; Yaegashi, Taku; Anma, Takeshi

    2009-03-20

    The advantage of the higher signal-to-noise ratio (SNR) of 3-Tesla magnetic resonance imaging (3-Tesla) has the possibility of contributing to the improvement of high spatial resolution without causing image deterioration. In this study, we compared SNR and the apparent diffusion coefficient (ADC) value with 3-Tesla as the condition in the diffusion-weighted image (DWI) parameter of the 1.5-Tesla magnetic resonance imaging (1.5-Tesla) and we examined the high spatial resolution images in the imaging method [respiratory-triggering (RT) method and breath free (BF) method] and artifact (motion and zebra) in the upper abdominal region of DWI at 3-Tesla. We have optimized scan parameters based on phantom and in vivo study. As a result, 3-Tesla was able to obtain about 1.5 times SNR in comparison with the 1.5-Tesla, ADC value had few differences. Moreover, the RT method was effective in correcting the influence of respiratory movement in comparison with the BF method, and image improvement by the effective acquisition of SNR and reduction of the artifact were provided. Thus, DWI of upper abdominal region was a useful sequence for the high spatial resolution in 3-Tesla.

  5. 3-Tesla functional magnetic resonance imaging-guided tumor resection

    Energy Technology Data Exchange (ETDEWEB)

    Hall, W.A. [Univ. of Minnesota Medical School, Minneapolis, MN (United States). Depts. of Neurosurgery; Univ. of Minnesota Medical School, Minneapolis, MN (United States). Dept. of Radiation Oncology; Univ. of Minnesota Medical School, Minneapolis, MN (United States). Dept. of Radiology; University of Minnesota Medical Center (MMC), Minneapolis, MN (United States); Truwit, C.L. [Univ. of Minnesota Medical School, Minneapolis, MN (United States). Dept. of Radiology; Univ. of Minnesota Medical School, Minneapolis, MN (United States). Dept. of Pediatrics; Univ. of Minnesota Medical School, Minneapolis, MN (United States). Dept. of Neurology; Hennepin Country Medical Center, Minneapolis, MN (United States). Dept. of Radiology

    2006-12-15

    Objective: We sought to determine the safety and efficacy of using 3-tesla (T) functional magnetic resonance imaging (fMRI) to guide brain tumor resection. Material and methods: From February 2004 to March 2006, fMRI was performed on 13 patients before surgical resection. Functional imaging was used to identify eloquent cortices for motor (8), speech (3), and motor and speech (2) activation using two different 3-T magnetic resonance (MR) scanners. Surgical resection was accomplished using a 1.5-T intraoperative MR system. Appropriate MR scan sequences were performed intraoperatively to determine and maximize the extent of the surgical resection. Results: Tumors included six oligodendrogliomas, three meningiomas, two astrocytomas and two glioblastomas multiforme. The fMRI data was accurate in all cases. After surgery, two patients had hemiparesis, two had worsening of their speech, and one had worsening of speech and motor function. Neurological function returned to normal in all patients within 1 month. Complete resections were possible in 10 patients (77%). Two patients had incomplete resections because of the proximity of their tumors to functional areas. Biopsy was performed in another patient with an astrocytoma in the motor strip. Conclusion: 3-T fMRI was accurate for locating neurologic function before tumor resection near eloquent cortex. (orig.)

  6. 3-Tesla functional magnetic resonance imaging-guided tumor resection

    International Nuclear Information System (INIS)

    Hall, W.A.; Truwit, C.L.; Univ. of Minnesota Medical School, Minneapolis, MN; Univ. of Minnesota Medical School, Minneapolis, MN; Hennepin Country Medical Center, Minneapolis, MN

    2006-01-01

    Objective: We sought to determine the safety and efficacy of using 3-tesla (T) functional magnetic resonance imaging (fMRI) to guide brain tumor resection. Material and methods: From February 2004 to March 2006, fMRI was performed on 13 patients before surgical resection. Functional imaging was used to identify eloquent cortices for motor (8), speech (3), and motor and speech (2) activation using two different 3-T magnetic resonance (MR) scanners. Surgical resection was accomplished using a 1.5-T intraoperative MR system. Appropriate MR scan sequences were performed intraoperatively to determine and maximize the extent of the surgical resection. Results: Tumors included six oligodendrogliomas, three meningiomas, two astrocytomas and two glioblastomas multiforme. The fMRI data was accurate in all cases. After surgery, two patients had hemiparesis, two had worsening of their speech, and one had worsening of speech and motor function. Neurological function returned to normal in all patients within 1 month. Complete resections were possible in 10 patients (77%). Two patients had incomplete resections because of the proximity of their tumors to functional areas. Biopsy was performed in another patient with an astrocytoma in the motor strip. Conclusion: 3-T fMRI was accurate for locating neurologic function before tumor resection near eloquent cortex. (orig.)

  7. Overview of electrical axis measurement in TESLA-type cavities

    International Nuclear Information System (INIS)

    Labanc, Anton

    2007-01-01

    The cells of TESLA cavities are mechanically aligned and tuned before the cavities are installed into the cryomodule. The alignment minimizes unwanted interaction of the accelerated beam with the transverse electric field component and the magnetic field of the accelerating TM 010 -π mode. It also reduces an interaction with higher order modes. The tuning equalizes field amplitudes of the accelerating mode in all cells. Until now, the eccentricity (misalignment) of cells is measured mechanically with residual misalignment after tuning up to 0.4 mm. Unfortunately the mechanical measurement is only weakly related to the electromagnetic fields inside a cavity, both for the accelerating and higher order modes. For improvement of the precision a new method of electromagnetic field mapping inside a cavity, based on small perturbation theory was developed. This method can be applied to modes which do not propagate through the beam pipes. In the setup built for the axis measurement a metallic needle is used as field perturbing object. Conducted tests confirmed high precision of 0.1 mm. Tests on the copper model for which it is possible to excite all of considered modes and on several niobium cavities were performed. In this paper an overview of measurement method, equipment and first results are reported. (orig.)

  8. A Passively-Suspended Tesla Pump Left Ventricular Assist Device

    Science.gov (United States)

    Izraelev, Valentin; Weiss, William J.; Fritz, Bryan; Newswanger, Raymond K.; Paterson, Eric G.; Snyder, Alan; Medvitz, Richard B.; Cysyk, Joshua; Pae, Walter E.; Hicks, Dennis; Lukic, Branka; Rosenberg, Gerson

    2009-01-01

    The design and initial test results of a new passively suspended Tesla type LAVD blood pump are described. CFD analysis was used in the design of the pump. Overall size of the prototype device is 50 mm in diameter and 75 mm in length. The pump rotor has a density lower than that of blood and when spinning inside the stator in blood it creates a buoyant centering force that suspends the rotor in the radial direction. The axial magnetic force between the rotor and stator restrain the rotor in the axial direction. The pump is capable of pumping up to 10 liters/min at a 70 mmHg head rise at 8000 RPM. The pump has demonstrated a normalized index of hemolysis level below .02 mg/dL for flows between 2 and 9.7 L/min. An inlet pressure sensor has also been incorporated into the inlet cannula wall and will be used for control purposes. One initial in vivo study showed an encouraging result. Further CFD modeling refinements are planned as well as endurance testing of the device. PMID:19770799

  9. Imaging of patients with hippocampal sclerosis at 7 Tesla: initial results.

    Science.gov (United States)

    Breyer, Tobias; Wanke, Isabel; Maderwald, Stefan; Woermann, Friedrich G; Kraff, Oliver; Theysohn, Jens M; Ebner, Alois; Forsting, Michael; Ladd, Mark E; Schlamann, Marc

    2010-04-01

    Focal epilepsies potentially can be cured by neurosurgery; other treatment options usually remain symptomatic. High-resolution magnetic resonance (MR) imaging is the central imaging strategy in the evaluation of focal epilepsy. The most common substrate of temporal epilepsies is hippocampal sclerosis (HS), which cannot always be sufficiently characterized with current MR field strengths. Therefore, the purpose of our study was to demonstrate the feasibility of high-resolution MR imaging at 7 Tesla in patients with focal epilepsy resulting from a HS and to improve image resolution at 7 Tesla in patients with HS. Six patients with known HS were investigated with T1-, T2-, T2(*)-, and fluid-attenuated inversion recovery-weighted sequences at 7 Tesla with an eight-channel transmit-receive head coil. Total imaging time did not exceed 90 minutes per patient. High-resolution imaging at 7 Tesla is feasible and reveals high resolution of intrahippocampal structures in vivo. HS was confirmed in all patients. The maximum non-interpolated in-plane resolution reached 0.2 x 0.2 mm(2) in T2(*)-weighted images. The increased susceptibility effects at 7 Tesla revealed identification of intrahippocampal structures in more detail than at 1.5 Tesla, but otherwise led to stronger artifacts. Imaging revealed regional differences in hippocampal atrophy between patients. The scan volume was limited because of specific absorption rate restrictions, scanning time was reasonable. High-resolution imaging at 7 Tesla is promising in presurgical epilepsy imaging. "New" contrasts may further improve detection of even very small intrahippocampal structural changes. Therefore, further investigations will be necessary to demonstrate the potential benefit for presurgical selection of patients with various lesion patterns in mesial temporal epilepsies resulting from a unilateral HS. Copyright 2010 AUR. Published by Elsevier Inc. All rights reserved.

  10. Comparing Laser Desorption Ionization and Atmospheric Pressure Photoionization Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry To Characterize Shale Oils at the Molecular Level

    Science.gov (United States)

    Cho, Yunjo; Jin, Jang Mi; Witt, Matthias; Birdwell, Justin E.; Na, Jeong-Geol; Roh, Nam-Sun; Kim, Sunghwan

    2013-01-01

    Laser desorption ionization (LDI) coupled to Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) was used to analyze shale oils. Previous work showed that LDI is a sensitive ionization technique for assessing aromatic nitrogen compounds, and oils generated from Green River Formation oil shales are well-documented as being rich in nitrogen. The data presented here demonstrate that LDI is effective in ionizing high-double-bond-equivalent (DBE) compounds and, therefore, is a suitable method for characterizing compounds with condensed structures. Additionally, LDI generates radical cations and protonated ions concurrently, the distribution of which depends upon the molecular structures and elemental compositions, and the basicity of compounds is closely related to the generation of protonated ions. This study demonstrates that LDI FT-ICR MS is an effective ionization technique for use in the study of shale oils at the molecular level. To the best of our knowledge, this is the first time that LDI FT-ICR MS has been applied to shale oils.

  11. Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Cyclotron Frequency.

    Science.gov (United States)

    Nagornov, Konstantin O; Kozhinov, Anton N; Tsybin, Yury O

    2017-04-01

    The phenomenon of ion cyclotron resonance allows for determining mass-to-charge ratio, m/z, of an ensemble of ions by means of measurements of their cyclotron frequency, ω c . In Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), the ω c quantity is usually unavailable for direct measurements: the resonant state is located close to the reduced cyclotron frequency (ω + ), whereas the ω c and the corresponding m/z values may be calculated via theoretical derivation from an experimental estimate of the ω + quantity. Here, we describe an experimental observation of a new resonant state, which is located close to the ω c frequency and is established because of azimuthally-dependent trapping electric fields of the recently developed ICR cells with narrow aperture detection electrodes. We show that in mass spectra, peaks close to ω + frequencies can be reduced to negligible levels relative to peaks close to ω c frequencies. Due to reduced errors with which the ω c quantity is obtained, the new resonance provides a means of cyclotron frequency measurements with precision greater than that achieved when ω + frequency peaks are employed. The described phenomenon may be considered for a development into an FT-ICR MS technology with increased mass accuracy for applications in basic research, life, and environmental sciences. Graphical Abstract ᅟ.

  12. Improving heat generation of magnetic nanoparticles by pre-orientation of particles in a static three tesla magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Beck, Mathias M., E-mail: Mathias.Beck@tum.de [Institute for Machine Tools and Industrial Management, Technical University of Munich, Boltzmannstr. 15, 85748 Garching (Germany); Lammel, Christian [Institute for Machine Tools and Industrial Management, Technical University of Munich, Boltzmannstr. 15, 85748 Garching (Germany); Gleich, Bernhard [Institute of Medical Engineering, Technical University of Munich, Boltzmannstr. 11, 85748 Garching (Germany)

    2017-04-01

    Inductive heating of electrically insulating materials like fiberglass reinforced thermoplastics (FRTP) without susceptors is not possible. However, due to their low thermal conductivity a volumetric heat generation method is advisable to reach short heating times to melt this material for reshaping. This can be done with magnetic nanoparticles as susceptors within the thermoplastic of the FRTP using Néel relaxation. During the heating process the particle's magnetic moment rotates with the field while the particle itself is fixed within the thermoplastic. Therefore the heat dissipation of each particle depends on its orientation within the field. To achieve the maximum heat generation of the particles we pre-oriented the particles within a plastic at the best angle to the applied AC field for induction. To do this, five mass percent nanoparticles were dispersed in an epoxy resin, which was then hardened at room temperature in a static three Tesla magnetic field. After its solidification the heating behavior of the sample was compared to a reference sample, which was hardened without a field. The oriented particles showed an increased heating rate when oriented parallel to the applied AC field. The absorption rate was 3.3 times as high as the undirected reference sample. When the alternating electromagnetic field was perpendicular to the oriented particles, the specific absorption rate was similar to that of the reference sample. We compare this result with theory and with calculations from literature, and conduct a numerical simulation. - Highlights: • Magnetic nanoparticles are aligned using a static three tesla magnetic field. • Inductive heating depends on the particles pre-orientation in a solid matrix. • Alignment increases the heat generation significantly.

  13. A Laminar Flow-Based Microfluidic Tesla Pump via Lithography Enabled 3D Printing.

    Science.gov (United States)

    Habhab, Mohammed-Baker; Ismail, Tania; Lo, Joe Fujiou

    2016-11-23

    Tesla turbine and its applications in power generation and fluid flow were demonstrated by Nicholas Tesla in 1913. However, its real-world implementations were limited by the difficulty to maintain laminar flow between rotor disks, transient efficiencies during rotor acceleration, and the lack of other applications that fully utilize the continuous flow outputs. All of the aforementioned limits of Tesla turbines can be addressed by scaling to the microfluidic flow regime. Demonstrated here is a microscale Tesla pump designed and fabricated using a Digital Light Processing (DLP) based 3D printer with 43 µm lateral and 30 µm thickness resolutions. The miniaturized pump is characterized by low Reynolds number of 1000 and a flow rate of up to 12.6 mL/min at 1200 rpm, unloaded. It is capable of driving a mixer network to generate microfluidic gradient. The continuous, laminar flow from Tesla turbines is well-suited to the needs of flow-sensitive microfluidics, where the integrated pump will enable numerous compact lab-on-a-chip applications.

  14. A Laminar Flow-Based Microfluidic Tesla Pump via Lithography Enabled 3D Printing

    Directory of Open Access Journals (Sweden)

    Mohammed-Baker Habhab

    2016-11-01

    Full Text Available Tesla turbine and its applications in power generation and fluid flow were demonstrated by Nicholas Tesla in 1913. However, its real-world implementations were limited by the difficulty to maintain laminar flow between rotor disks, transient efficiencies during rotor acceleration, and the lack of other applications that fully utilize the continuous flow outputs. All of the aforementioned limits of Tesla turbines can be addressed by scaling to the microfluidic flow regime. Demonstrated here is a microscale Tesla pump designed and fabricated using a Digital Light Processing (DLP based 3D printer with 43 µm lateral and 30 µm thickness resolutions. The miniaturized pump is characterized by low Reynolds number of 1000 and a flow rate of up to 12.6 mL/min at 1200 rpm, unloaded. It is capable of driving a mixer network to generate microfluidic gradient. The continuous, laminar flow from Tesla turbines is well-suited to the needs of flow-sensitive microfluidics, where the integrated pump will enable numerous compact lab-on-a-chip applications.

  15. Diagnostic usefulness of 3 tesla MRI of the brain for cushing disease in a child.

    Science.gov (United States)

    Ono, Erina; Ozawa, Ayako; Matoba, Kaori; Motoki, Takanori; Tajima, Asako; Miyata, Ichiro; Ito, Junko; Inoshita, Naoko; Yamada, Syozo; Ida, Hiroyuki

    2011-10-01

    It is sometimes difficult to confirm the location of a microadenoma in Cushing disease. Recently, we experienced an 11-yr-old female case of Cushing disease with hyperprolactinemia. She was referred to our hospital because of decrease of height velocity with body weight gain. On admission, she had typical symptoms of Cushing syndrome. Although no pituitary microadenomas were detected on 1.5 Tesla MRI of the brain, endocrinological examinations including IPS and CS sampling were consistent with Cushing disease with hyperprolactinemia. Oral administration of methyrapone instead of neurosurgery was started after discharge, but subsequent 3 Tesla MRI of the brain clearly demonstrated a 3-mm less-enhanced lesion in the left side of the pituitary gland. Finally, transsphenoidal surgery was performed, and a 3.5-mm left-sided microadenoma was resected. Compared with 1.5 Tesla MRI, 3 Tesla MRI offers the advantage of a higher signal to noise ratio (SNR), which provides higher resolution and proper image quality. Therefore, 3 Tesla MRI is a very useful tool to localize microadenomas in Cushing disease in children as well as in adults. It will be the first choice of radiological examinations in suspected cases of Cushing disease.

  16. MRI safety of a programmable shunt assistant at 3 and 7 Tesla.

    Science.gov (United States)

    Mirzayan, M Javad; Klinge, Petra M; Samii, Madjid; Goetz, Friedrich; Krauss, Joachim K

    2012-06-01

    Several new shunt technologies have been developed to optimize hydrocephalus treatment within the past few years. Overdrainage, however, still remains an unresolved problem. One new technology which may reduce the frequency of this complication is the use of a programmable shunt assistant (proSA). Inactive in a horizontal position, it impedes CSF flow in a vertical position according to a prescribed pressure level ranging from 0 to 40 cm H(2)O. We exposed the proSA valve in an ex vivo protocol to MR systems operating at 3 and 7 Tesla to investigate its MRI safety. Following 3 Tesla exposure, no changes in valve settings were noted. Adjustment to any pressure level was possible thereafter. The mean deflection angle was 23 ± 3°. After exposure to 7 Tesla, however, there were unintended pressure changes, and the mechanism for further adjustment of the valves even disintegrated. According to the results of this study, proSA is safe with heteropolar vertical magnet alignment at 3 Tesla. Following 7 Tesla exposure, the valves lost their functional capability.

  17. Conceptual design of a 20 Tesla pulsed solenoid for a laser solenoid fusion reactor

    International Nuclear Information System (INIS)

    Nolan, J.J.; Averill, R.J.

    1977-01-01

    Design considerations are described for a strip wound solenoid which is pulsed to 20 tesla while immersed in a 20 tesla bias field so as to achieve within the bore of the pulsed solenoid at net field sequence starting at 20 tesla and going first down to zero, then up to 40 tesla, and finally back to 20 tesla in a period of about 5 x 10 -3 seconds. The important parameters of the solenoid, e.g., aperture, build, turns, stored and dissipated energy, field intensity and powering circuit, are given. A numerical example for a specific design is presented. Mechanical stresses in the solenoid and the subsequent choice of materials for coil construction are discussed. Although several possible design difficulties are not discussed in this preliminary report of a conceptual magnet design, such as uniformity of field, long-term stability of insulation under neutron bombardment and choice of structural materials of appropriate tensile strength and elasticity to withstand magnetic forces developed, these questions are addressed in detail in the complete design report and in part in reference one. Furthermore, the authors feel that the problems encountered in this conceptual design are surmountable and are not a hindrance to the construction of such a magnet system

  18. A low noise single-transistor transimpedance preamplifier for Fourier-transform mass spectrometry using a T feedback network.

    Science.gov (United States)

    Lin, Tzu-Yung; Green, Roger J; O'Connor, Peter B

    2012-09-01

    A novel single-transistor transimpedance preamplifier has been introduced for improving performance in Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry. A low noise junction field-effect transistor (JFET), BF862, is used as the main amplification stage of this trans-impedance preamplifier, and a T-shaped feedback network is introduced as both the feedback and the gate biasing solutions. The T feedback network has been studied using an operational amplifier (Op Amp), AD8099. Such a feedback system allows ~100-fold less feedback resistance at a given transimpedance, hence preserving bandwidth, which is beneficial to applications demanding high gain. The single-transistor preamplifier yields a tested transimpedance of ~10(4) Ω (80 dBΩ) in the frequency range between 1 kHz and 1 MHz (mass-to-charge ratio, m/z, of around 180-180k for a 12-T FT-ICR system), with a low power consumption of ~6 mW, which implies that this preamplifier is well suited to a 12-T FT-ICR mass spectrometer. In trading noise performance for higher trans-impedance, an alternative preamplifier design, an AD8099 preamplifier with the T feedback network, has also been studied with a capability of ~10(6) Ω (120 dBΩ) transimpedance in the same frequency range. The resistive components in the T feedback network reported here can be replaced by complex impedances, which allows adaptation of this feedback system to other frequency, transimpedance, and noise characteristics for applications not only in other mass spectrometers, such as Orbitrap, time-of-flight (TOF), and ion trap systems, but also in other charge/current detecting systems such as spectroscopy systems, microscopy systems, optical communication systems, or charge-coupled devices (CCDs).

  19. Toward imaging the body at 10.5 tesla.

    Science.gov (United States)

    Ertürk, M Arcan; Wu, Xiaoping; Eryaman, Yiğitcan; Van de Moortele, Pierre-François; Auerbach, Edward J; Lagore, Russell L; DelaBarre, Lance; Vaughan, J Thomas; Uğurbil, Kâmil; Adriany, Gregor; Metzger, Gregory J

    2017-01-01

    To explore the potential of performing body imaging at 10.5 Tesla (T) compared with 7.0T through evaluating the transmit/receive performance of similarly configured dipole antenna arrays. Fractionated dipole antenna elements for 10.5T body imaging were designed and evaluated using numerical simulations. Transmit performance of antenna arrays inside the prostate, kidneys and heart were investigated and compared with those at 7.0T using both phase-only radiofrequency (RF) shimming and multi-spoke pulses. Signal-to-noise ratio (SNR) comparisons were also performed. A 10-channel antenna array was constructed to image the abdomen of a swine at 10.5T. Numerical methods were validated with phantom studies at both field strengths. Similar power efficiencies were observed inside target organs with phase-only shimming, but RF nonuniformity was significantly higher at 10.5T. Spokes RF pulses allowed similar transmit performance with accompanying local specific absorption rate increases of 25-90% compared with 7.0T. Relative SNR gains inside the target anatomies were calculated to be >two-fold higher at 10.5T, and 2.2-fold SNR gain was measured in a phantom. Gradient echo and fast spin echo imaging demonstrated the feasibility of body imaging at 10.5T with the designed array. While comparable power efficiencies can be achieved using dipole antenna arrays with static shimming at 10.5T; increasing RF nonuniformities underscore the need for efficient, robust, and safe parallel transmission methods. Magn Reson Med 77:434-443, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  20. Pathway confirmation and flux analysis of central metabolic pathways in Desulfovibrio vulgaris Hildenborough using Gas Chromatography-Mass Spectrometry and Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry

    International Nuclear Information System (INIS)

    Tang, Yinjie; Pingitore, Francesco; Mukhopadhyay, Aindrila; Phan, Richard; Hazen, Terry C.; Keasling, Jay D.

    2007-01-01

    Flux distribution in central metabolic pathways of Desulfovibrio vulgaris Hildenborough was examined using 13C tracer experiments. Consistent with the current genome annotation and independent evidence from enzyme activity assays, the isotopomer results from both GC-MS and Fourier Transform-Ion Cyclotron Resonance mass spectrometry (FT-ICR MS) indicate the lack of oxidatively functional TCA cycle and an incomplete pentose phosphate pathway. Results from this study suggest that fluxes through both pathways are limited to biosynthesis. The data also indicate that >80 percent of the lactate was converted to acetate and the reactions involved are the primary route of energy production (NAD(P)H and ATP production). Independent of the TCA cycle, direct cleavage of acetyl-CoA to CO and 5,10-methyl-THF also leads to production of NADH and ATP. Although the genome annotation implicates a ferredoxin-dependent oxoglutarate synthase, isotopic evidence does not support flux through this reaction in either the oxidative or reductive mode; therefore, the TCA cycle is incomplete. FT-ICR MS was used to locate the labeled carbon distribution in aspartate and glutamate and confirmed the presence of an atypical enzyme for citrate formation suggested in previous reports (the citrate synthesized by this enzyme is the isotopic antipode of the citrate synthesized by the (S)-citrate synthase). These findings enable a better understanding of the relation between genome annotation and actual metabolic pathways in D. vulgaris, and also demonstrate FT-ICR MS as a powerful tool for isotopomer analysis, overcoming problems in both GC-MS and NMR spectroscopy

  1. Nikola Tesla: Why was he so much resisted and forgotten? [Retrospectroscope].

    Science.gov (United States)

    Valentinuzzi, Max E; Ortiz, Martin Hill; Cervantes, Daniel; Leder, Ron S

    2016-01-01

    Recently, during the Christmas season, a friend of mine visited me and, sneaking a look at my bookshelves, found two rather old Nikola Tesla biographies, which I had used to prepare a "Retrospectroscope" column for the then-named IEEE Engineering in Medicine and Biology Magazine when our dear friend Alvin Wald was its editor-inchief [2]. Eighteen years have elapsed since then; soon, the idea came up of revamping the article. Cynthia Weber, the magazine's current associate editor, considered it acceptable, and here is the new note divided in two parts: that is, a slightly revised version of the original article followed by new material, including some quite interesting information regarding Tesla's homes and laboratories. On top of this, Tesla is not devoid of a science fiction touch, as mentioned at the end.

  2. Low frequency AC losses in multi filamentary superconductors up to 15 Tesla

    International Nuclear Information System (INIS)

    Orlando, T.; Braun, C.; Foner, S.; Schwartz, B.; Zieba, A.

    1983-01-01

    Low frequency (1 Hz) ac losses were measured in a variety of A15 superconducting wires having different fiber geometries. Field modulations ofless than or equal to 1 tesla were superimposed on a fixed background field up to 15 tesla. Losses were measured for Nb 3 Sn in continuous fiber, modified jelly-roll, In Situ, and powder metallurgy processed materials, and for Nb 3 Al powder metallurgy processed materials. The results are compared with dc magnetization measurements. The losses are purely hysteretic at these low frequencies, scale with J /SUB c/ (above about 3 tesla), and are reduced substantially by twisting for all the materials. The lowest losses are observed for the Nb 3 Al wires

  3. Design and performance of a Tesla transformer type relativistic electron beam generator

    International Nuclear Information System (INIS)

    Jain, K.K.; Chennareddy, D.; John, P.I.; Saxena, Y.C.

    1986-01-01

    A relativistic electron beam generator driven by an air core Tesla transformer is described. The Tesla transformer circuit analysis is outlined and computational results are presented for the case when the coaxial water line has finite resistance. The transformer has a coupling coefficient of 0.56 and a step-up ratio of 25. The Tesla transformer can provide 800 kV at the peak of the second half cycle of the secondary output voltage and has been tested up to 600 kV. A 100-200 keV, 15-20 kA electron beam having 150 ns pulse width has been obtained. The beam generator described is being used for the beam injection into a toroidal device BETA. (author). 20 refs. 9 figures

  4. Theoretical and Experimental Research Performed on the Tesla Turbine - Part I

    Directory of Open Access Journals (Sweden)

    Dorian Nedelcu

    2015-09-01

    Full Text Available The paper presents the theoretical and experimental research performed on a Tesla turbine driven by compressed air and designed to equip a teaching laboratory [1], [2]. It introduces the operating principle of the Tesla turbine, which was invented by engineer Nikola Tesla, a turbine which uses discs instead of blades, mounted on a shaft at a small distance between them. The turbine geometry, results from stress and flow calculations performed on the turbine rotor and assembly, using the Simulation modules and SolidWorks Flow Simulation program are presented. After designing the turbine, it becomes the subject of experimental research to determine the curve of the speed depending on the pressure. Also, the experimental research focuses on the behaviour of the turbine from a dynamic point of view [3].

  5. Note: Tesla based pulse generator for electrical breakdown study of liquid dielectrics

    Science.gov (United States)

    Veda Prakash, G.; Kumar, R.; Patel, J.; Saurabh, K.; Shyam, A.

    2013-12-01

    In the process of studying charge holding capability and delay time for breakdown in liquids under nanosecond (ns) time scales, a Tesla based pulse generator has been developed. Pulse generator is a combination of Tesla transformer, pulse forming line, a fast closing switch, and test chamber. Use of Tesla transformer over conventional Marx generators makes the pulse generator very compact, cost effective, and requires less maintenance. The system has been designed and developed to deliver maximum output voltage of 300 kV and rise time of the order of tens of nanoseconds. The paper deals with the system design parameters, breakdown test procedure, and various experimental results. To validate the pulse generator performance, experimental results have been compared with PSPICE simulation software and are in good agreement with simulation results.

  6. Note: A high-energy-density Tesla-type pulse generator with novel insulating oil

    Science.gov (United States)

    Liu, Sheng; Su, Jiancang; Fan, Xuliang

    2017-09-01

    A 10-GW high-energy-density Tesla-type pulse generator is developed with an improved insulating liquid based on a modified Tesla pulser—TPG700, of which the pulse forming line (PFL) is filled with novel insulating oil instead of transformer oil. Properties of insulating oil determining the stored energy density of the PFL are analyzed, and a criterion for appropriate oil is proposed. Midel 7131 is chosen as an application example. The results of insulating property experiment under tens-of-microsecond pulse charging demonstrate that the insulation capability of Midel 7131 is better than that of KI45X transformer oil. The application test in Tesla pulser TPG700 shows that the output power is increased to 10.5 GW with Midel 7131. The output energy density of TPG700 increases for about 60% with Midel 7131.

  7. Prognostic Metabolite Biomarkers for Soft Tissue Sarcomas Discovered by Mass Spectrometry Imaging

    Science.gov (United States)

    Lou, Sha; Balluff, Benjamin; Cleven, Arjen H. G.; Bovée, Judith V. M. G.; McDonnell, Liam A.

    2017-02-01

    Metabolites can be an important read-out of disease. The identification and validation of biomarkers in the cancer metabolome that can stratify high-risk patients is one of the main current research aspects. Mass spectrometry has become the technique of choice for metabolomics studies, and mass spectrometry imaging (MSI) enables their visualization in patient tissues. In this study, we used MSI to identify prognostic metabolite biomarkers in high grade sarcomas; 33 high grade sarcoma patients, comprising osteosarcoma, leiomyosarcoma, myxofibrosarcoma, and undifferentiated pleomorphic sarcoma were analyzed. Metabolite MSI data were obtained from sections of fresh frozen tissue specimens with matrix-assisted laser/desorption ionization (MALDI) MSI in negative polarity using 9-aminoarcridine as matrix. Subsequent annotation of tumor regions by expert pathologists resulted in tumor-specific metabolite signatures, which were then tested for association with patient survival. Metabolite signals with significant clinical value were further validated and identified by high mass resolution Fourier transform ion cyclotron resonance (FTICR) MSI. Three metabolite signals were found to correlate with overall survival ( m/z 180.9436 and 241.0118) and metastasis-free survival ( m/z 160.8417). FTICR-MSI identified m/z 241.0118 as inositol cyclic phosphate and m/z 160.8417 as carnitine.

  8. Diagnosis of glenoid labral tears using 3-tesla MRI vs. 3-tesla MRA: a systematic review and meta-analysis.

    Science.gov (United States)

    Ajuied, Adil; McGarvey, Ciaran P; Harb, Ziad; Smith, Christian C; Houghton, Russell P; Corbett, Steven A

    2018-05-01

    Various protocols exist for magnetic resonance arthrogram (MRA) of the shoulder, including 3D isotropic scanning and positioning in neutral (2D neutral MRA), or abduction-external-rotation (ABER). MRA does not improve diagnostic accuracy for labral tears when compared to magnetic resonance imaging (MRI) performed using 3-Tesla (3T) magnets. Systematic review of the Cochrane, MEDLINE, and PubMed databases according to PRISMA guidelines. Included studies compared 3T MRI or 3T MRA (index tests) to arthroscopic findings (reference test). Methodological appraisal performed using QUADAS-2. Pooled sensitivity and specificity were calculated. Ten studies including 929 patients were included. Index test bias and applicability were a concern in the majority of studies. The use of arthroscopy as the reference test raised concern of verification bias in all studies. For anterior labral lesions, 3T MRI was less sensitive (0.83 vs. 0.87 p = 0.083) than 3T 2D neutral MRA. Compared to 3T 2D neutral MRA, both 3T 3D Isotropic MRA and 3T ABER MRA significantly improved sensitivity (0.87 vs. 0.95 vs. 0.94). For SLAP lesions, 3T 2D neutral MRA was of similar sensitivity to 3T MRI (0.84 vs. 0.83, p = 0.575), but less specific (0.99 vs. 0.92 p < 0.0001). For posterior labral lesions, 3T 2D neutral MRA had greater sensitivity than 3T 3D Isotropic MRA and 3T MRI (0.90 vs. 0.83 vs. 0.83). At 3-T, MRA improved sensitivity for diagnosis of anterior and posterior labral lesions, but reduced specificity in diagnosis of SLAP tears. 3T MRA with ABER positioning further improved sensitivity in diagnosis of anterior labral tears. IV.

  9. An energy upgrade from TESLA to a high-energy μ+μ- collider

    International Nuclear Information System (INIS)

    Neuffer, D.; Edwards, H.; Finley, D.

    1996-10-01

    We discuss the possible extension of a TESLA 250X250 GeV SRF e + e - linear collider to a multi-TeV μ + μ - collider, by future addition of a muon source, return arcs for recirculation and a collider ring. The TESLA SRF systems are potentially also suitable for multiturn acceleration of muon bunches, and could be adapted for use in a recirculating μ-linac. Many problems and design issues would need to be resolved, and further study is needed

  10. Use of Tesla NZK 203 neutron probe in studying water as geochemical factor in weathering zone

    International Nuclear Information System (INIS)

    Hally, J.

    1980-01-01

    The Tesla NZK 203 neutron moisture gage was used for determining soil moisture in depths of 1 and 2 meters in the Luha-Kacerov profile in the Zelivka water reservoir basin. The borehole spacing was 100 m. Measurements were made once a month between May and October 1978. The results were compared with the granulometric composition and the values of the specific surface areas of earths in the area. The Tesla NZK 203 moisture gage was fully proven for speedy measurement of volume moisture at constant measuring points. (Ha)

  11. Strategic Alliance with Competitors in the Electric Vehicle Market: Tesla Motor’s Case

    Directory of Open Access Journals (Sweden)

    Taesu Cheong

    2016-01-01

    Full Text Available We investigate how the choice of coopetition of the simultaneous pursuit of collaboration and competition dynamically impacts both the participating firms and also the other self-developing ones in the same market. A conceptual framework of mathematical models obtained from the arguments and insights in the literature is used to undertake an in-depth study through a multiperiod analysis from 2013 to 2020 of an exemplar case of coopetition, the two concurrently ongoing coopetition partnerships in the US electric vehicle (EV market, the Tesla Motors-Daimler AG alliance and the Tesla Motors-Toyota alliance and the other firms which are not involved in coopetition.

  12. First cold test of TESLA superconducting RF cavity in horizontal cryostat (CHECHIA)

    International Nuclear Information System (INIS)

    Kuzminski, J.

    1996-01-01

    In the framework of the TESLA project, the horizontal cryostat (CHECHIA) was built to test a superconducting RF cavity equipped with its helium vessel, magnetic shielding, cold tuner, main coupler and higher order modes couplers under realistic conditions before final assembly of eight cavities into TESLA Test Facility cryo-module. The results of the first cold tests in CHECHIA, performed at DESY with a 9-cell cavity (C19) to be used in the TTF injector are presented. Additional measurements of mechanical stability under RF operation (frequency variation with He pressure, Lorentz detuning) and cryogenic and electric measurements of power dissipation are presented. (author)

  13. Test measurement of a new TESLA cavity beam position monitor at the ELBE linac

    International Nuclear Information System (INIS)

    Sargsyan, V.; Schreiber, H.J.; Evtushenko, P.; Schurig, R.

    2004-01-01

    A new type of a cavity BPM proposed for beam position determination along the TESLA linac was tested at the accelerator ELBE in Rossendorf / Dresden. Measurements using an improved BPM (large and stable cross-talk isolation, significantly less energy dissipation, a novel LO signal generation) were performed in single- and multi-bunch regimes. Agreement with expectations was found. The low bunch charge available allowed for preliminary measurements on sensitivity and position resolution, which extrapolated to TESLA would ful l the demands for precise bunch-to-bunch position determination. Possible improvements, in particular on the signal processing scheme, are also discussed. (orig.)

  14. Functional and perfusion magnetic resonance imaging at 3 tesla

    International Nuclear Information System (INIS)

    Klarhoefer, M.

    2001-03-01

    This thesis deals with the development and optimization of fast magnetic resonance imaging (MRI) methods for non-invasive functional studies of the human brain and perfusion imaging on a 3 Tesla (T) whole body NMR system. The functional MRI (fMRI) experiments performed showed that single-shot multi-echo EPI and spiral imaging techniques provide fast tools to obtain information about T2* distributions during functional activation in the human brain. Both sequences were found to be useful in the separation of different sources contributing to the functional MR signal like inflow or susceptibility effects in the various vascular environments. An fMRI study dealing with the involvement of prefrontal brain regions in movement preparation lead to inconsistent results. It could not be clarified if these were caused by problems during a spatial normalization process of the individual brains or if the functional paradigm, using very short inter-stimulus intervals, was not suited for the problem investigated. Blood flow velocity measurements in the human finger showed that the use of a strong, small-bore gradient system permits short echo times that reduce flow artefacts and allows high spatial resolution in order to keep systematic errors due to partial volume effects small. With regard to the perfusion investigations an inversion recovery snapshot-FLASH sequence was implemented, which allowed the acquisition of T1 parameter maps of the human brain within a few seconds. The accuracy of this method was demonstrated in test objects. The perfusion investigations with FAIR showed good qualitative results, whereas the quantitative analysis did not yield reproducible findings. A reason for the poor results could be the low signal-to-noise ratio (SNR) of the FAIR images or an incomplete global inversion of the magnetization due to the transmission characteristics of the radio-frequency coil. The BASE sequence that did not require a global inversion yielded quantitative perfusion

  15. Modelling Wireless Power Transfer Using an Array of Tesla Coils

    Science.gov (United States)

    Pierson, Casey Thomas

    Wireless power transmission, or WPT, is a well-demonstrated property in electrical science and physics. Coil-and-wave transmission (CWT) consists of two Tesla coils, one powered by a controlled voltage source v src and one connected across a generic load Z 0 , at a mid- to long range distance apart with spherical capacitors at each of their top loads. The literature on the different methods of WPT varies widely, but research of CWT is sparse, lacking especially in the area of computer simulation. Recently, a physical experiment was conducted by Marzolf et al. in [1], and yielded surprising resonant frequencies in the high frequency range. The goal of this research is to answer the question of whether these reosnant frequencies originate in unexplained field effects or in non-ideal circuit behavior, and establish a formal model to indicate at what frequencies the resonant peaks occur as a first approximation. By carefully constructing a simulation of the most geometrically simple, power efficient design in the work of Marzolf et al. using the scientific software Octave, we investigate these frequencies computationally: first, an ideal scenario that has no flux leakage or exterior losses is modelled mathematically and simulated, and then, a non-ideal scenario that accounts for losses in the coils and surroundings is modelled mathematically and simulated. Both models utilize a simple formula for spherical capacitance for the top loads. After running these simulations through detailed sampling up to 4 MHz, the ideal model could not account for the resonant peaks, while the non-ideal model indicated the resonant peaks near the exact frequency ranges that were observed. An unexpected characteristic of these results was that coupling coefficients between the coils of the transmitter and receiver played a noticeable part in the indication of resonant peaks. This demonstrates that unknown field effects are not the primary driver of resonance in the ideal or non

  16. Optimization of materials for the parts that compose a Tesla turbine; Otimizacao de materiais para as partes que compoe uma turbina tipo Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, Geovana Vilas Boas da, E-mail: geovana_dmp@yahoo.com.br [Universidade Federal de Sao Paulo (UNIFESP), Sao Jose dos Campos, SP (Brazil); Guimaraes, Lamartine N.F.; Placco, Guilherme M., E-mail: guimarae@ieav.cta.br, E-mail: placco@ieav.cta.br [Instituto de Estudos Avancados (IEAv), Sao Jose dos Campos, SP (Brazil). Divisao de Energia Nuclear

    2013-07-01

    The TERRA project (Tecnologia de Reatores Rapidos Avancados) of the Aeronautica (Brazil) aims to develop the necessary technologies for the design of nuclear microreactors. These, in turn, aim to address the thermal and electrical needs in space vehicles. One of the activities of this project is to build a closed thermal cycle, the Rankine type in order to test a Tesla turbine type developed by the group. In this thermodynamic cycle the water is transformed into steam, which triggers a turbine which, in turn, provide power to the alternator to be converted into electricity. The work presented a survey of the materials available on the national market for machining a Tesla type turbine. The surveys were made considering the characteristics and operating conditions of a specific thermal cycle, the interest of the group. Results: cost-benefit tables for each party of the turbine, characteristics of each material, the machining process, as well as a comparison between one of 304L stainless steel model turbine with a turbine with the selected materials. The results from this study raised the level of sophistication of the research involved the TERRA project, since the study of ideal materials that make up the parts of a Tesla type turbine in a heat cycle is unprecedented.

  17. MR imaging of the prostate at 3 Tesla: comparison of an external phased-array coil to imaging with an endorectal coil at 1.5 Tesla.

    Science.gov (United States)

    Sosna, Jacob; Pedrosa, Ivan; Dewolf, William C; Mahallati, Houman; Lenkinski, Robert E; Rofsky, Neil M

    2004-08-01

    To qualitatively compare the image quality of torso phased-array 3-Tesla (3T) imaging of the prostate with that of endorectal 1.5-Tesla imaging. Twenty cases of torso phased-array prostate imaging performed at 3-Tesla with FSE T2 weighted images were evaluated by two readers independently for visualization of the posterior border (PB), seminal vesicles (SV), neurovascular bundles (NVB), and image quality rating (IQR). Studies were performed at large fields of view(FOV) (25 cm) (14 cases) (3TL) and smaller FOV (14 cm) (19 cases) (3TS). A comparison was made to 20 consecutive cases of 1.5-T endorectal evaluation performed during the same time period.Results. 3TL produced a significantly better image quality compared with the small FOV for PB (P = .0001), SV (P =.0001), and IQR (P = .0001). There was a marginally significant difference within the NVB category (P = .0535). 3TL produced an image of similar quality to image quality at 1.5 T for PB (P = .3893), SV (P = .8680), NB (P = .2684), and IQR (P = .8599). Prostate image quality at 3T with a torso phased-array coil can be comparable with that of endorectal 1.5-T imaging. These findings suggest that additional options are now available for magnetic resonance imaging of the prostate gland.

  18. Study and development of an input coupler for the future TESLA collider

    International Nuclear Information System (INIS)

    Dupery, C.

    1996-01-01

    The TESLA (TeV Superconducting Linear Accelerator) is operating with a high frequency cavity resonator input coupler. Some technical restraints (such as thermal, mechanical, electrical, vacuum, multipactor discharge phenomena) constrain the development of this coupler. In order to solve these problems, studies have been performed at the French Atomic Energy Commission (CEA) and are presented in this paper

  19. Structural analysis of TFTR TF coils and support structure for 6 Tesla operation

    International Nuclear Information System (INIS)

    Zatz, I.J.; Cargulia, G.; Lontai, L.

    1995-01-01

    The Tokamak Fusion Test Reactor (TFTR), which has been on line since December 1982, has successfully operated at its design Toroidal Field (TF) of 5.2 Tesla. Analysis of test data has indicated that the measured peak D-D neutron power in supershots may be scaled to the fourth power of TF field. Increasing the TF field to 6 Tesla provides the opportunity to explore the possibility of improving the D-T fusion yield, with the use of tritium. This increase in TF field from 5.2 to 6.0 Tesla increases the centering force by 33% and the out-of-plane force by 15% over previous peak operating levels. To examine the impact of the increase in loads on the TF coil, case and supporting structure, finite element analyses (FEA) were performed with and without the presence of loose bolts in the TF case. Note that the loose bolts comprise a fraction of the total number of bolts fastening the TF case sidewalls to the inner and outer rings of the case. Extensive analysis was performed using the FEA results in conjunction with supplementary calculations. Results are presented for the TF case, bolts, copper conductors, insulation, and supporting structure which indicate that the TF coils can successfully operate at 6 Tesla for a reasonable number of pulses

  20. Interventional MR imaging: Clinical results obtained with a 1.5 Tesla system

    International Nuclear Information System (INIS)

    Adam, G.; Guenther, R.W.

    1997-01-01

    The clinical feasibility of using interventional examination techniques was tested with an equipment combining fluoroscopy and MR imaging. This hybrid system showed to be of advantage in a great number of interventional examinations. The 1.5 Tesla magnet proved to be superior to open MR scanning systems in terms of image quality and scanning times. (orig.) [de

  1. Design study of 15-Tesla RHQT Nb3Al block type dipole magnet

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, R.; Ambrosio, G.; Barzi, E.; Kashikin, V.; Kikuchi, A.; Novitski, I.; Takeuchi, T.; Wake, M.; Zlobin, A.; /Fermilab /NIMC, Tsukuba /KEK, Tsukuba

    2005-09-01

    The design study of the block type 15-Tesla RHQT Nb{sub 3}Al dipole magnet, and its merits over Nb{sub 3}Sn magnets are presented. The copper stabilized RHQT Nb{sub 3}Al strand is now becoming commercially available for the application to the accelerator magnets. A 1 mm diameter RHQT Nb{sub 3}Al strand with filament size about 50 {mu}, non-copper Jc about 1000 A/mm{sup 2} at 15 Tesla at 4.2K, copper ratio of 50%, can now be produced over several hundred meters. The stress and strain characteristics of the Nb{sub 3}Al strand are superior to the Nb{sub 3}Sn strand. Another advantage is that it can tolerate a longitudinal strain up to 0.55%. The RHQT Nb{sub 3}Al Rutherford cable will have less chance of contamination of the stabilizer, compared to Nb{sub 3}Sn cable. These characteristics of the RHQT Nb{sub 3}Al will be beneficial for designing and producing 15-Tesla dipole magnets. An example 15-Tesla magnet cross section, utilizing the RHQT Nb{sub 3}Sn strand is presented. A systematic investigation on RHQT Nb{sub 3}Al strands, its Rutherford cables, and building a small racetrack magnet for cable testing are proposed.

  2. Hippocampal disconnection in early Alzheimer's disease: a 7 tesla MRI study

    NARCIS (Netherlands)

    Wisse, L.E.; Reijmer, Y.D.; Telgte, A. ter; Kuijf, H.J.; Leemans, A.; Luijten, P.R.; Koek, H.L.; Geerlings, M.I.; Biessels, G.J.

    2015-01-01

    BACKGROUND: In patients with Alzheimer's disease (AD), atrophy of the entorhinal cortex (ERC) and hippocampal formation may induce degeneration of connecting white matter tracts. OBJECTIVE: We examined the association of hippocampal subfield and ERC atrophy at 7 tesla MRI with fornix and

  3. Seven tesla MRI improves detection of focal cortical dysplasia in patients with refractory focal epilepsy

    NARCIS (Netherlands)

    Veersema, Tim J; Ferrier, Cyrille H; van Eijsden, Pieter; Gosselaar, Peter H; Aronica, Eleonora; Visser, Fredy; Zwanenburg, Jaco M; de Kort, Gerard A P; Hendrikse, Jeroen; Luijten, Peter R; Braun, Kees P J

    Objective: The aim of this study is to determine whether the use of 7 tesla (T) MRI in clinical practice leads to higher detection rates of focal cortical dysplasias in possible candidates for epilepsy surgery. Methods: In our center patients are referred for 7 T MRI if lesional focal epilepsy is

  4. On the possibility of a normal conducting photo-injector for Tesla

    International Nuclear Information System (INIS)

    Travier, C.

    1992-12-01

    The possibility of using a normal conducting photo-injector for the TESLA linear collider is investigated. It is shown that the 8 nC,3 ps bunch can be produced with a normalized emittance less than 100 Π mm mrad. The generation of the train depends on the feasibility of the laser which has to be looked at more carefully

  5. Status of the GA/MCA 12 Tesla Coil Development Program

    International Nuclear Information System (INIS)

    Alcorn, J.S.; Purcell, J.R.; Chen, W.Y.; Hsu, Y.H.

    1980-09-01

    The current status of the Team One effort of the DOE/OFE/D and T 12 Tesla Coil Development Program is presented. Subatmospheric, helium bath cooled, NbTiTa alloy is employed for the test coil, and ETF TF-coil concept. General Atomic is the Team One leader, with Magnetic Corporation of American as industrial subcontractor

  6. Reproducibility of 3.0 Tesla Magnetic Resonance Spectroscopy for Measuring Hepatic Fat Content

    NARCIS (Netherlands)

    van Werven, Jochem R.; Hoogduin, Johannes M.; Nederveen, Aart J.; van Vliet, Andre A.; Wajs, Ewa; Vandenberk, Petra; Stroes, Erik S. G.; Stoker, Jaap

    Purpose: To investigate reproducibility of proton magnetic resonance spectroscopy (H-1-MRS) to measure hepatic triglyceride content (HTGC). Materials and Methods: In 24 subjects, HTGC was evaluated using H-1-MRS at 3.0 Tesla. We studied "between-weeks" reproducibility and reproducibility of H-1-MRS

  7. The success of the 11-Tesla project and its potential beyond particle physics

    CERN Multimedia

    CERN Bulletin

    2013-01-01

    On 7 March, the 1-metre-long single-aperture dipole model magnet under testing at Fermilab reached a current of 12.54 kA corresponding to a bore field of 11.5 Tesla, thus surpassing the goal set for the 11 T dipole project.   Computer generated model of the FNAL 1 metre 11 T dipole model magnet and a pair of CERN coils. Image: courtesy of Don Mitchell, FNAL. The 11-Tesla dipole project originated from a proposal made by High Luminosity LHC project coordinator, Lucio Rossi, in September 2010. To cope with the increasing amount of debris hitting the magnets when increasing the number of collisions produced by the LHC, he suggested replacing a few 8-Tesla dipole magnets in the LHC tunnel with shorter, stronger 11-Tesla magnets in order to create enough space to install additional collimators. The only way to achieve this goal is to use advanced niobium-tin technology. Rossi’s proposal aligned well with the goals of Fermilab’s High-Field Magnet R&D programme, which aims t...

  8. Cavity-Type BPMs For The TESLA Test Facility Free Electron Laser

    CERN Document Server

    Waldmann, H

    2003-01-01

    For measurements of the beam position at the undulator section of the TESLA Test Facility (TTF) at DESY cavity-type beam position monitors were developed, installed and brought into operation. Besides of some theoretical aspects results of in-beam measurements at the TTF are presented and pros and cons of this monitor concept are discussed.

  9. Predesign Study of a 4-5 tesla Superconducting Wiggler Magnet for the ESRF

    NARCIS (Netherlands)

    ten Kate, Herman H.J.; ter Avest, D.; ter Avest, D.; Ravex, A.; Lagnier, M.; Elleaume, P.

    1994-01-01

    The ESRF is currently setting up a beam line for very hard photons well above 250 keV. This requires the installation of a high field three polewavelength shifter. The nominal and target fields of the wiggler magnet are 4 and 5 tesla respectively while the nominal field integral over the central

  10. Tesla's coherent plasma discharge -and- a plan for megavolts at Megahertz

    International Nuclear Information System (INIS)

    Nichson, J.D.

    1987-01-01

    In his lecture on Experiments With Alternate Currents of High Potential and High Frequency before the Institute of Electrical Engineers in London (1892), Tesla reports a discharge through a partially evacuated air tube of 1 meter length and 1 inch diameter. It is characterized by the following properties: (1) The filamentary discharge may be locally displaced by a nearby dielectric body or a magnet. (2) When the filament is released, it demonstrates behaviour similar to that of a string which suspends a weight, including the formation of standing waves with distinct nodes. (3) Its decay time is on the order of 8 minutes. (4) The vibrating filament may be split with a magnet to produce two vibrating filaments. (5) This effect could only be formed with a dynamo-driven coil at low air pressures in the tube. The disruptive discharge coil (coloquially a Tesla Coil) failed to produce the effect with its superior voltage and frequency range. It is here proposed that this phenomenon is related to positive leader formation. A model for this, consistent for AC and DC discharges, is advanced. Also, a novel method for regulation of a nitrogen-filled spark gap will be proposed. It is hoped that this new device will produce smooth, uniform discharges from the Tesla Coil. This, if theory is correct on many points, will reproduce Tesla's coherent plasma at higher pressures in free-standing form, and will allow other novel effects

  11. Encouraging a "Romantic Understanding" of Science: The Effect of the Nikola Tesla Story

    Science.gov (United States)

    Hadzigeorgiou, Yannis; Klassen, Stephen; Klassen, Cathrine Froese

    2012-01-01

    The purpose of this paper is to discuss and apply the notion of romantic understanding by outlining its features and its potential role in science education, to identify its features in the story of Nikola Tesla, and to describe an empirical study conducted to determine the effect of telling such a story to Grade 9 students. Elaborated features of…

  12. Cortical microinfarcts detected in vivo on 3 Tesla MRI: clinical and radiological correlates.

    Science.gov (United States)

    van Dalen, Jan Willem; Scuric, Eva E M; van Veluw, Susanne J; Caan, Matthan W A; Nederveen, Aart J; Biessels, Geert Jan; van Gool, Willem A; Richard, Edo

    2015-01-01

    Cortical microinfarcts (CMIs) are a common postmortem finding associated with vascular risk factors, cognitive decline, and dementia. Recently, CMIs identified in vivo on 7 Tesla MRI also proved retraceable on 3 Tesla MRI. We evaluated CMIs on 3 Tesla MRI in a population-based cohort of 194 nondemented older people (72-80 years) with systolic hypertension. Using a case-control design, participants with and without CMIs were compared on age, sex, cardiovascular risk factors, and white matter hyperintensity volume. We identified 23 CMIs in 12 participants (6%). CMIs were associated with older age, higher diastolic blood pressure, and a history of recent stroke. There was a trend for a higher white matter hyperintensity volume in participants with CMIs. We found an association of CMIs with clinical parameters, including age and cardiovascular risk factors. Although the prevalence of CMIs is relatively low, our results suggest that the study of CMIs in larger clinical studies is possible using 3 Tesla MRI. This opens the possibility of large-scale prospective investigation of the clinical relevance of CMIs in older people. © 2014 American Heart Association, Inc.

  13. Prospects for 6 to 10 tesla magnets for a TEVATRON upgrade

    International Nuclear Information System (INIS)

    Mantsch, Paul M.

    1988-01-01

    The first SSC physics is at least 10 years away. An upgrade of the Fermilab Tevatron will ensure the continuity of a vigorous high-energy physics program until the SSC turns on. Three basic proposals are under consideration: /bar p/p at 3 /times/ 10 31 --Increase luminosity by improvements to the p source. pp at 1 TeV and 2 /times/ 10 32 --Move the main ring to a new tunnel, build a second Tevatron ring, and /bar p/p > 1.5 TeV and 7 /times/ 10 30 --Replace the tevatron with a higher energy ring. The last two options requires about a hundred 6.6-tesla dipoles in addition to a ring of Tevatron strength (4.4 T) magnets. These higher-field magnets are necessary in both rings to lengthen the straight sections in order to realize the collision optics. The third option requires a ring of magnets of 6.6 T or slightly higher to replace the present Tevatron plus a number of special 8--9 tesla magnets. The viability of the high-energy option then depends on the practicality of sizable numbers of reliable 8--9 tesla dipoles as well as 800 6.6-tesla dipoles. The following develops a specification for an 8.8 T dipole, examines the design considerations and reviews the current state of high-field magnet development. 22 figs., 3 tabs

  14. Impetus for TESLA ! DESY welcomes decision of the Federal Research Ministry on large-scale facilities

    CERN Multimedia

    2003-01-01

    Based on the decision published today by the Federal Minister of Education and Research, Edelgard Bulmahn, the preparations for TESLA will now enter a new phase. For the X-ray laser project, the first step will be to work out the financial, technical and organizational framework with the interested European partners (1 page).

  15. Vantage TitanTM 3T 3-tesla MRI system with enhanced serviceability and comfort

    International Nuclear Information System (INIS)

    Kanazawa, Hitoshi; Okamoto, Kazuya; Yamamoto, Takao

    2011-01-01

    Since 3-tesla magnetic resonance imaging (MRI) systems appeared on the market, in addition to their clinical usefulness a variety of issues have been pointed out in the clinical setting. The 3-tesla MRI system has therefore gained a reputation as a difficult system suitable only for hospital facilities including university hospitals that specialize in medical research. To rectify this situation, Toshiba Medical Systems Corporation has developed the Vantage Titan TM 3T, which is expected to not only improve the MRI examination environment, but also to be applicable to patients with claustrophobia and those with large physiques for whom MRI examination has not been appropriate until now, while maintaining the clinical usefulness of the 3-tesla MRI system. The Vantage Titan 3T system also incorporates the Pianissimo TM noise reduction mechanism, which has already been introduced in our 1.5-tesla MRI system and has been highly evaluated by the market. This reduces the stress of patients by providing a quieter and more open examination environment compared with conventional MRI systems. (author)

  16. NIKOLA TESLA AND MEDICINE: 160TH ANNIVERSARY OF THE BIRTH OF THE GENIUS WHO GAVE LIGHT TO THE WORLD - PART I.

    Science.gov (United States)

    Vucevic, Danijela; Dordevic, Drago; Radosavljevic, Tatjana

    2016-09-01

    The interest in Nikola Tesla, a scientist, physicist, engineer and inventor, is constantly growing. In the millennialong history of human civilization, it is almost impossible to find another person whose life and work has been under so much scrutiny of such a wide range of researchers, medical professionals included. Although Tesla was not primarily dedicated to biomedical research, his work significantly contributed to the development of radiology, and high frequency electrotherapy. This paper deals with the impact of Tesla's work on the development of a new medical branch - radiology. Nikola Tesla and the Discovery of X-ray radiation. Tesla pioneered the use of X-rays for medical purposes, practically laying the foundations of radiology. Namely, since 1887, Tesla periodically experimented with X-rays, at that time still unknown and unnamed, which he called "shadowgraphs". Moreover, at the end of 1894, lie conducted extensive research focusing on X-rays, but unfortunately it was inlerrupted after the fire burning down his laboratory in 1895. In 1896 and 1897, Tesla published ten papers on the biologic effects of X-ray radiation. All his studies on X-rays were experimental. During 1896 and 1897, Tesla continued improving X-ray devices. Apart from this, Tesla was the first to point out the harmful effects of exposure to X-ray radiation on human body. Nikola Tesla was a visionary genius of the future. Tesla's pioneer steps, made more than a century ago in the domain of radiology, are still being used today.

  17. 4.5 Tesla magnetic field reduces range of high-energy positrons -- Potential implications for positron emission tomography

    International Nuclear Information System (INIS)

    Wirrwar, A.; Vosberg, H.; Herzog, H.; Halling, H.; Weber, S.; Mueller-Gaertner, H.W.; Forschungszentrum Juelich GmbH

    1997-01-01

    The authors have theoretically and experimentally investigated the extent to which homogeneous magnetic fields up to 7 Tesla reduce the spatial distance positrons travel before annihilation (positron range). Computer simulations of a noncoincident detector design using a Monte Carlo algorithm calculated the positron range as a function of positron energy and magnetic field strength. The simulation predicted improvements in resolution, defined as full-width at half-maximum (FWHM) of the line-spread function (LSF) for a magnetic field strength up to 7 Tesla: negligible for F-18, from 3.35 mm to 2.73 mm for Ga-68 and from 3.66 mm to 2.68 mm for Rb-82. Also a substantial noise suppression was observed, described by the full-width at tenth-maximum (FWTM) for higher positron energies. The experimental approach confirmed an improvement in resolution for Ga-68 from 3.54 mm at 0 Tesla to 2.99 mm FWHM at 4.5 Tesla and practically no improvement for F-18 (2.97 mm at 0 Tesla and 2.95 mm at 4.5 Tesla). It is concluded that the simulation model is appropriate and that a homogeneous static magnetic field of 4.5 Tesla reduces the range of high-energy positrons to an extent that may improve spatial resolution in positron emission tomography

  18. Qualitative metabolome analysis of human cerebrospinal fluid by 13C-/12C-isotope dansylation labeling combined with liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry.

    Science.gov (United States)

    Guo, Kevin; Bamforth, Fiona; Li, Liang

    2011-02-01

    Metabolome analysis of human cerebrospinal fluid (CSF) is challenging because of low abundance of metabolites present in a small volume of sample. We describe and apply a sensitive isotope labeling LC-MS technique for qualitative analysis of the CSF metabolome. After a CSF sample is divided into two aliquots, they are labeled by (13)C-dansyl and (12)C-dansyl chloride, respectively. The differentially labeled aliquots are then mixed and subjected to LC-MS using Fourier-transform ion cyclotron resonance mass spectrometry (FTICR MS). Dansylation offers significant improvement in the performance of chromatography separation and detection sensitivity. Moreover, peaks detected in the mass spectra can be readily analyzed for ion pair recognition and database search based on accurate mass and/or retention time information. It is shown that about 14,000 features can be detected in a 25-min LC-FTICR MS run of a dansyl-labeled CSF sample, from which about 500 metabolites can be profiled. Results from four CSF samples are compared to gauge the detectability of metabolites by this method. About 261 metabolites are commonly detected in replicate runs of four samples. In total, 1132 unique metabolite ion pairs are detected and 347 pairs (31%) matched with at least one metabolite in the Human Metabolome Database. We also report a dansylation library of 220 standard compounds and, using this library, about 85 metabolites can be positively identified. Among them, 21 metabolites have never been reported to be associated with CSF. These results illustrate that the dansylation LC-FTICR MS method can be used to analyze the CSF metabolome in a more comprehensive manner. © American Society for Mass Spectrometry, 2011

  19. Prostate cancer detection by prebiopsy 3.0-tesla magnetic resonance imaging

    International Nuclear Information System (INIS)

    Nishida, Sachiyo; Kinoshita, Hidefumi; Mishima, Takao; Kurokawa, Hiroaki; Sakaida, Noriko; Matsuda, Tadashi

    2011-01-01

    The diagnostic value of 3.0-Tesla magnetic resonance imaging (MRI) for prostate cancer remains to be determined. The aim of the present study was to assess the features of prostate cancer detectable by prebiopsy 3.0-Tesla MRI. From January 2007 through to December 2008, 116 patients who were examined by prebiopsy 3.0-Tesla MRI underwent radical prostatectomy for localized prostate cancer. Prostate specimens were examined to see whether the largest cancer area was the same as the area indicated on the MRI. Univariate and multivariate logistic regression analyses were conducted to identify variables predictive of agreement between MRI and histopathological findings. Sixty-six (56.9%) patients were suspected of having prostate cancer on the basis of MRI findings. In 49 of these patients (74.2%), it was considered that there was agreement between the abnormal area on the MRI and the index tumor. Univariate analysis revealed that there were significant differences in abnormal digital rectal examination, capsular penetration, the diameter of the index tumor of the radical prostatectomy specimen, and the Gleason scores of the biopsy and radical prostatectomy specimens. Multivariate analysis revealed that the Gleason score of the radical prostatectomy specimen was associated with the accurate detection of the prostate cancer by MRI (P=0.0177). In conclusion, 3.0-Tesla MRI tends to accurately diagnose prostate cancer with high tumor burden and aggressiveness. Multimodal examination (T2-weighted imaging, dynamic contrast-enhanced imaging, and diffusion-weighted imaging) is recommended for the diagnosis of prostate cancer using 3.0-Tesla MRI. (author)

  20. Qualitative Metabolome Analysis of Human Cerebrospinal Fluid by 13C-/12C-Isotope Dansylation Labeling Combined with Liquid Chromatography Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    Science.gov (United States)

    Guo, Kevin; Bamforth, Fiona; Li, Liang

    2011-02-01

    Metabolome analysis of human cerebrospinal fluid (CSF) is challenging because of low abundance of metabolites present in a small volume of sample. We describe and apply a sensitive isotope labeling LC-MS technique for qualitative analysis of the CSF metabolome. After a CSF sample is divided into two aliquots, they are labeled by 13C-dansyl and 12C-dansyl chloride, respectively. The differentially labeled aliquots are then mixed and subjected to LC-MS using Fourier-transform ion cyclotron resonance mass spectrometry (FTICR MS). Dansylation offers significant improvement in the performance of chromatography separation and detection sensitivity. Moreover, peaks detected in the mass spectra can be readily analyzed for ion pair recognition and database search based on accurate mass and/or retention time information. It is shown that about 14,000 features can be detected in a 25-min LC-FTICR MS run of a dansyl-labeled CSF sample, from which about 500 metabolites can be profiled. Results from four CSF samples are compared to gauge the detectability of metabolites by this method. About 261 metabolites are commonly detected in replicate runs of four samples. In total, 1132 unique metabolite ion pairs are detected and 347 pairs (31%) matched with at least one metabolite in the Human Metabolome Database. We also report a dansylation library of 220 standard compounds and, using this library, about 85 metabolites can be positively identified. Among them, 21 metabolites have never been reported to be associated with CSF. These results illustrate that the dansylation LC-FTICR MS method can be used to analyze the CSF metabolome in a more comprehensive manner.

  1. Technical Note: Molecular characterization of aerosol-derived water soluble organic carbon using ultrahigh resolution electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

    Directory of Open Access Journals (Sweden)

    R. M. Dickhut

    2008-09-01

    Full Text Available Despite the acknowledged relevance of aerosol-derived water-soluble organic carbon (WSOC to climate and biogeochemical cycling, characterization of aerosol WSOC has been limited. Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS was utilized in this study to provide detailed molecular level characterization of the high molecular weight (HMW; m/z>223 component of aerosol-derived WSOC collected from rural sites in Virginia and New York, USA. More than 3000 peaks were detected by ESI FT-ICR MS within a m/z range of 223–600 for each sample. Approximately 86% (Virginia and 78% (New York of these peaks were assigned molecular formulas using only carbon (C, hydrogen (H, oxygen (O, nitrogen (N, and sulfur (S as elemental constituents. H/C and O/C molar ratios were plotted on van Krevelen diagrams and indicated a strong contribution of lignin-like and lipid-like compounds to the aerosol-derived WSOC samples. Approximately 1–4% of the peaks in the aerosol-derived WSOC mass spectra were classified as black carbon (BC on the basis of double bond equivalents calculated from the assigned molecular formulas. In addition, several high-magnitude peaks in the mass spectra of samples from both sites corresponded to molecular formulas proposed in previous secondary organic aerosol (SOA laboratory investigations indicating that SOAs are important constituents of the WSOC. Overall, ESI FT-ICR MS provides a level of resolution adequate for detailed compositional and source information of the HMW constituents of aerosol-derived WSOC.

  2. Natural radioactivity of coal and fly ash at the Nikola Tesla B TPP

    Directory of Open Access Journals (Sweden)

    Kisić Dragica M.

    2013-01-01

    Full Text Available Serbian thermal power plants (TPPs produce siliceous fly ash from lignite in the quantity of approximately 6 million tons per year. The potential market for the use of fly ash is operational, but for the time being, only used by cement producers. Fly ash radioactivity could be one of the major points of concern when larger use of fly ash is planned, particularly in the Serbian construction industry. Radioactivity measurements have been conducted regularly for decades. This paper presents the results of a ten-year fly ash radioactivity measurements at the Nikola Tesla B TPP located in Obrenovac. In addition, the paper compares the natural radionuclides coal content data combusted by the Nikola Tesla B TPP boilers coming from the Kolubara Basin and ash created during coal combustion. Fly ash created in the Nikola Tesla TPPs boilers is characterised by the increased concentration of the natural radionuclides content compared to coal. This is the so-called technologically enhanced natural radioactivity (Technologically Enhanced Occurring Radioactive Material - TENORM of industrial waste, whereas the average specific activities: 232Th in coal amount to 25.2 Bq/kg, and in fly ash and coal 84.2 Bq/kg and 238U 38.3 Bq/kg, respectively. Following the obtained natural radionuclides content results it may be concluded that the Nikola Tesla B TPP ash may be disposed into the environment. Ash may be used also in the construction industry (civil engineering. In building construction applications, ash share as the additive to other building materials depends from its physical and chemical characteristics, as well as from the radionuclides activity: 266Ra, 232Th and 40K. Unlike the thermal power plants regularly (once a year testing the specific natural radionuclides activity in the combusted coal and boiler fly ash, Electric Power Industry of Serbia has not performed large-scale investigations of the natural radionuclides content in coal within the Kolubara

  3. Normalization Approaches for Removing Systematic Biases Associated with Mass Spectrometry and Label-Free Proteomics

    Energy Technology Data Exchange (ETDEWEB)

    Callister, Stephen J.; Barry, Richard C.; Adkins, Joshua N.; Johnson, Ethan T.; Qian, Weijun; Webb-Robertson, Bobbie-Jo M.; Smith, Richard D.; Lipton, Mary S.

    2006-02-01

    Central tendency, linear regression, locally weighted regression, and quantile techniques were investigated for normalization of peptide abundance measurements obtained from high-throughput liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS). Arbitrary abundances of peptides were obtained from three sample sets, including a standard protein sample, two Deinococcus radiodurans samples taken from different growth phases, and two mouse striatum samples from control and methamphetamine-stressed mice (strain C57BL/6). The selected normalization techniques were evaluated in both the absence and presence of biological variability by estimating extraneous variability prior to and following normalization. Prior to normalization, replicate runs from each sample set were observed to be statistically different, while following normalization replicate runs were no longer statistically different. Although all techniques reduced systematic bias, assigned ranks among the techniques revealed significant trends. For most LC-FTICR MS analyses, linear regression normalization ranked either first or second among the four techniques, suggesting that this technique was more generally suitable for reducing systematic biases.

  4. RF Phase Reference Distribution System for the TESLA Technology Based Projects

    CERN Document Server

    Czuba, K; Romaniuk, R S

    2013-01-01

    Since many decades physicists have been building particle accelerators and usually new projects became more advanced, more complicated and larger than predecessors. The importance and complexity of the phase reference distribution systems used in these accelerators have grown significantly during recent years. Amongst the most advanced of currently developed accelerators are projects based on the TESLA technology. These projects require synchronization of many RF devices with accuracy reaching femtosecond levels over kilometre distances. Design of a phase reference distribution system fulfilling such requirements is a challenging scientific task. There are many interdisciplinary problems which must be solved during the system design. Many, usually negligible issues, may became very important in such system. Furthermore, the design of a distribution system on a scale required for the TESLA technology based projects is a new challenge and there is almost no literature sufficiently covering this subject. This th...

  5. Clinical impacts of 3.0 Tesla magnetic resonance imaging in stroke patients

    International Nuclear Information System (INIS)

    Inoue, Takashi; Ogasawara, Kuniaki; Ogawa, Akira

    2004-01-01

    The progress of the magnetic resonance (MR) imaging in the cerebral stroke patients was remarkable, and it became possible to evaluate a brain perfusion or function. Here, we describe about the clinical application of the neuronal tracts and brain perfusion evaluation using 3.0 Tesla MR imaging. The subjects were patients with internal cerebral hemorrhage and major cerebral occlusive diseases. Three dimensional anisotropy contrast (3DAC) imaging and diffusion tensor imaging (DTI) were accepted to estimate the damages of neurnal tracts. Perfusion weighted images with the contrast medium were performed for a quantitative evaluation. The pyramidal tracts were depicted well with 3DAC imaging. Fractional anisotropy (FA) value generated from DTI can predict the outcome of the motor dysfunction in each patient at early stage. Cerebral blood volume calculated from perfusion weighted imaging (PWI) was correlated with and cerebral vascular reserve capacity. 3.0 Tesla MR imaging may develop in cerebral stroke patients in near future. (author)

  6. Assessing the MR compatibility of dental retainer wires at 7 Tesla.

    Science.gov (United States)

    Wezel, Joep; Kooij, Bert Jan; Webb, Andrew G

    2014-10-01

    To determine the MR compatibility of common dental retainer wires at 7 Tesla in terms of potential RF heating and magnetic susceptibility effects. Electromagnetic simulations and experimental results were compared for dental retainer wires placed in tissue-mimicking phantoms. Simulations were then performed for a human model with wire in place. Finally, image quality was assessed for different scanning protocols and wires. Simulations and experimental data in phantoms agreed well, with the length of the wire correlating to maximum heating in phantoms being approximately 47 mm. Even in this case, no substantial heating occurs when scanning within the specific absorption rate (SAR) guidelines for the head. Image distortions from the most ferromagnetic dental wire were not significant for any brain region. Dental retainer wires appear to be MR compatible at 7 Tesla. Copyright © 2013 Wiley Periodicals, Inc.

  7. Cognitive Function and 3-Tesla Magnetic Resonance Imaging Tractography of White Matter Hyperintensities in Elderly Persons

    OpenAIRE

    Reginold, William; Luedke, Angela C.; Tam, Angela; Itorralba, Justine; Fernandez-Ruiz, Juan; Reginold, Jennifer; Islam, Omar; Garcia, Angeles

    2015-01-01

    Background/Aims: This study used 3-Tesla magnetic resonance imaging (MRI) tractography to determine if there was an association between tracts crossing white matter hyperintensities (WMH) and cognitive function in elderly persons. Methods: Brain T2-weighted fluid-attenuated inversion recovery (FLAIR) and diffusion tensor MRI scans were acquired in participants above the age of 60 years. Twenty-six persons had WMH identified on T2 FLAIR scans. They completed a battery of neuropsychological tes...

  8. Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users

    OpenAIRE

    Cowan, Ronald L.; Bolo, Nicolas R.; Dietrich, Mary; Haga, Erica; Lukas, Scott E.; Renshaw, Perry F.

    2007-01-01

    The recreational drug MDMA (3,4, methylenedioxymethamphetamine; sold under the street name of Ecstasy) is toxic to serotonergic axons in some animal models of MDMA administration. In humans, MDMA use is associated with alterations in markers of brain function that are pronounced in occipital cortex. Among neuroimaging methods, magnetic resonance spectroscopy (MRS) studies of brain metabolites N-acetylaspartate (NAA) and myoinositol (MI) at a field strength of 1.5 Tesla (T) reveal inconsistent...

  9. Diffusion tensor imaging of the spinal cord at 1.5 and 3.0 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, C. [Radiologische Universitaetsklinik, Tuebingen (Germany). Sektion fuer Experimentelle Radiologie; CNR-INFM CRS-Soft, La Sapienza-Univ. Roma (Italy); Enrico Fern Center, Roma (Italy); Boss, A.; Martirosian, P.; Steidle, G.; Schick, F. [Radiologische Universitaetsklinik, Tuebingen (Germany). Sektion fuer Experimentelle Radiologie; Lindig, T.M. [Enrico Fern Center, Roma (Italy); Radiologische Universitaetsklinik, Tuebingen (Germany). Sektion fuer Experimentelle Kernspinresonanz des ZNS; Universitaetsklinikum Tuebingen (Germany). Zentrum fuer Neurologie und Hertie-Inst. fuer klinische Hirnforschung; Maetzler, W. [Universitaetsklinikum Tuebingen (Germany). Zentrum fuer Neurologie und Hertie-Inst. fuer klinische Hirnforschung; Claussen, C.D. [Radiologische Universitaetsklinik, Tuebingen (Germany). Abt. fuer Radiologische Diagnostik; Klose, U. [Radiologische Universitaetsklinik, Tuebingen (Germany). Sektion fuer Experimentelle Kernspinresonanz des ZNS

    2007-03-15

    Purpose: The feasibility of highly resolved diffusion tensor imaging (DTI) of the human cervical spinal cord was tested on a clinical MR unit operating at 3.0 Tesla. DTI parametrical maps and signal-to-noise ratios (SNRs) were compared to results recorded at 1.5 Tesla. Materials and Methods: Eight healthy volunteers and one patient participated in the study. A transverse oriented single-shot ECG-triggered echo-planar imaging (EPI) sequence with double spin-echo diffusion preparation was applied for highly resolved DTI of the spinal cord. The signal yield, fractional anisotropy (FA), and mean diffusivity (MD) were compared for both field strengths. The clinical applicability of the protocol was also tested in one patient with amyotrophic lateral sclerosis (ALS) at 3.0 T. Results: A mean increase in SNR of 95.7 {+-} 4.6% was found at 3.0 Tesla compared to 1.5 Tesla. Improved quality of the DTI parametrical maps was observed at higher field strength (p < 0.02). Comparable FA and MD (reported in units of 10 - 3 mm2/s) values were computed in the dorsal white matter at both field strengths (1.5 T: FA = 0.75 {+-} 0.08, MD = 0.84 {+-} 0.12, 3.0 T: FA = 0.74 {+-} 0.04, MD = 0.93 {+-} 0.14). The DTI images exhibited diagnostic image quality in the patient. At the site of the diseased corticospinal tract, a decrease of 46.0 {+-} 3.8% in FA (0.40 {+-} 0.03) and an increase of 50.3 {+-} 5.6% in MD (1.40 {+-} 0.05) were found in the ALS patient. (orig.)

  10. BOLD cardiovascular magnetic resonance at 3.0 tesla in myocardial ischemia.

    OpenAIRE

    Manka, R; Paetsch, I; Schnackenburg, B; Gebker, R; Fleck, E; Jahnke, C

    2010-01-01

    Abstract Background The purpose of this study was to determine the ability of Blood Oxygen Level Dependent (BOLD) cardiovascular magnetic resonance (CMR) to detect stress-inducible myocardial ischemic reactions in the presence of angiographically significant coronary artery disease (CAD). Methods Forty-six patients (34 men; age 65 ± 9 years,) with suspected or known coronary artery disease underwent CMR at 3Tesla prior to clinically indicated invasive coronary angiography. BOLD CMR was perfor...

  11. The influence of potential exposure to radiation protection system of accelerator installation TESLA

    International Nuclear Information System (INIS)

    Orlic, M.; Cuknic, O.

    2000-01-01

    Potential exposure of individuals at big nuclear machines like Accelerator Installation Tesla (AIT) generates direct requirements to reliability of radiation protection system. Starting from technical characteristics of AlT and international recommendation concerning potential exposure and the probability of death has been calculated. The reference risk has been specified. Comparing then we calculated the probability of the failure of the protective system. The reliability of the system has to be better (author)

  12. Diseño y construcción de una bobina Tesla

    OpenAIRE

    Pérez de Obanos Francés, Eduardo

    2010-01-01

    El objetivo de este proyecto es diseñar y construir una bobina Tesla de tamaño medio y observar las descargas emitidas desde el terminal superior. Además se realizarán una serie de pruebas para comprobar si los resultados obtenidos en esta experiencia se asemejan a los de estudios anteriores. Ingeniería Técnica Industrial Industria Ingeniaritza Teknikoa

  13. The advancement of electric vehicles - case: Tesla Motors. Disruptive technology requiring systemic innovating

    OpenAIRE

    Lehtinen, Petri

    2015-01-01

    Electric vehicles have existed for over 100 years as a disruptive innovation. Even though they have always been easier to use, quieter and cleaner, gasoline cars have beaten it in price, range and faster fueling. As gasoline cars have been the technological standard for the past 150 years there has been no motivation by car manufacturers to advance electric vehicles. By producing electric vehicles Tesla Motors has appropriately become the first successful startup car manufacturer in over 100 ...

  14. Diffusion tensor imaging of the spinal cord at 1.5 and 3.0 Tesla

    International Nuclear Information System (INIS)

    Rossi, C.; Boss, A.; Martirosian, P.; Steidle, G.; Schick, F.; Lindig, T.M.; Radiologische Universitaetsklinik, Tuebingen; Universitaetsklinikum Tuebingen; Maetzler, W.; Claussen, C.D.; Klose, U.

    2007-01-01

    Purpose: The feasibility of highly resolved diffusion tensor imaging (DTI) of the human cervical spinal cord was tested on a clinical MR unit operating at 3.0 Tesla. DTI parametrical maps and signal-to-noise ratios (SNRs) were compared to results recorded at 1.5 Tesla. Materials and Methods: Eight healthy volunteers and one patient participated in the study. A transverse oriented single-shot ECG-triggered echo-planar imaging (EPI) sequence with double spin-echo diffusion preparation was applied for highly resolved DTI of the spinal cord. The signal yield, fractional anisotropy (FA), and mean diffusivity (MD) were compared for both field strengths. The clinical applicability of the protocol was also tested in one patient with amyotrophic lateral sclerosis (ALS) at 3.0 T. Results: A mean increase in SNR of 95.7 ± 4.6% was found at 3.0 Tesla compared to 1.5 Tesla. Improved quality of the DTI parametrical maps was observed at higher field strength (p < 0.02). Comparable FA and MD (reported in units of 10 - 3 mm2/s) values were computed in the dorsal white matter at both field strengths (1.5 T: FA = 0.75 ± 0.08, MD = 0.84 ± 0.12, 3.0 T: FA 0.74 ± 0.04, MD = 0.93 ± 0.14). The DTI images exhibited diagnostic image quality in the patient. At the site of the diseased corticospinal tract, a decrease of 46.0 ± 3.8% in FA (0.40 ± 0.03) and an increase of 50.3 ± 5.6% in MD (1.40 ± 0.05) were found in the ALS patient. (orig.)

  15. A compact multi-wire-layered secondary winding for Tesla transformer.

    Science.gov (United States)

    Zhao, Liang; Su, Jian-Cang; Li, Rui; Wu, Xiao-Long; Xu, Xiu-Dong; Qiu, Xu-Dong; Zeng, Bo; Cheng, Jie; Zhang, Yu; Gao, Peng-Cheng

    2017-05-01

    A compact multi-wire-layered (MWL) secondary winding for a Tesla transformer is put forward. The basic principle of this winding is to wind the metal wire on a polymeric base tube in a multi-layer manner. The tube is tapered and has high electrical strength and high mechanical strength. Concentric-circle grooves perpendicular to the axis of the tube are carved on the surface of the tube to wind the wire. The width of the groove is basically equal to the diameter of the wire so that the metal wire can be fixed in the groove without glue. The depth of the groove is n times of the diameter of the wire to realize the n-layer winding manner. All the concentric-circle grooves are connected via a spiral groove on the surface of the tube to let the wire go through. Compared with the traditional one-wire-layered (OWL) secondary winding for the Tesla transformer, the most conspicuous advantage of the MWL secondary winding is that the latter is compact with only a length of 2/n of the OWL. In addition, the MWL winding has the following advantages: high electrical strength since voids are precluded from the surface of the winding, high mechanical strength because polymer is used as the material of the base tube, and reliable fixation in the Tesla transformer as special mechanical connections are designed. A 2000-turn MWL secondary winding is fabricated with a winding layer of 3 and a total length of 1.0 m. Experiments to test the performance of this winding on a Tesla-type pulse generator are conducted. The results show that this winding can boost the voltage to 1 MV at a repetition rate of 50 Hz reliably for a lifetime longer than 10 4 pulses, which proves the feasibility of the MWL secondary winding.

  16. Rapid parametric mapping of the longitudinal relaxation time T1 using two-dimensional variable flip angle magnetic resonance imaging at 1.5 Tesla, 3 Tesla, and 7 Tesla.

    Science.gov (United States)

    Dieringer, Matthias A; Deimling, Michael; Santoro, Davide; Wuerfel, Jens; Madai, Vince I; Sobesky, Jan; von Knobelsdorff-Brenkenhoff, Florian; Schulz-Menger, Jeanette; Niendorf, Thoralf

    2014-01-01

    Visual but subjective reading of longitudinal relaxation time (T1) weighted magnetic resonance images is commonly used for the detection of brain pathologies. For this non-quantitative measure, diagnostic quality depends on hardware configuration, imaging parameters, radio frequency transmission field (B1+) uniformity, as well as observer experience. Parametric quantification of the tissue T1 relaxation parameter offsets the propensity for these effects, but is typically time consuming. For this reason, this study examines the feasibility of rapid 2D T1 quantification using a variable flip angles (VFA) approach at magnetic field strengths of 1.5 Tesla, 3 Tesla, and 7 Tesla. These efforts include validation in phantom experiments and application for brain T1 mapping. T1 quantification included simulations of the Bloch equations to correct for slice profile imperfections, and a correction for B1+. Fast gradient echo acquisitions were conducted using three adjusted flip angles for the proposed T1 quantification approach that was benchmarked against slice profile uncorrected 2D VFA and an inversion-recovery spin-echo based reference method. Brain T1 mapping was performed in six healthy subjects, one multiple sclerosis patient, and one stroke patient. Phantom experiments showed a mean T1 estimation error of (-63±1.5)% for slice profile uncorrected 2D VFA and (0.2±1.4)% for the proposed approach compared to the reference method. Scan time for single slice T1 mapping including B1+ mapping could be reduced to 5 seconds using an in-plane resolution of (2×2) mm2, which equals a scan time reduction of more than 99% compared to the reference method. Our results demonstrate that rapid 2D T1 quantification using a variable flip angle approach is feasible at 1.5T/3T/7T. It represents a valuable alternative for rapid T1 mapping due to the gain in speed versus conventional approaches. This progress may serve to enhance the capabilities of parametric MR based lesion detection and

  17. Non-enhanced magnetic resonance imaging of the small bowel at 7 Tesla in comparison to 1.5 Tesla: First steps towards clinical application.

    Science.gov (United States)

    Hahnemann, Maria L; Kraff, Oliver; Maderwald, Stefan; Johst, Soeren; Orzada, Stephan; Umutlu, Lale; Ladd, Mark E; Quick, Harald H; Lauenstein, Thomas C

    2016-06-01

    To perform non-enhanced (NE) magnetic resonance imaging (MRI) of the small bowel at 7 Tesla (7T) and to compare it with 1.5 Tesla (1.5T). Twelve healthy subjects were prospectively examined using a 1.5T and 7T MRI system. Coronal and axial true fast imaging with steady-state precession (TrueFISP) imaging and a coronal T2-weighted (T2w) half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequence were acquired. Image analysis was performed by 1) visual evaluation of tissue contrast and detail detectability, 2) measurement and calculation of contrast ratios and 3) assessment of artifacts. NE MRI of the small bowel at 7T was technically feasible. In the vast majority of the cases, tissue contrast and image details were equivalent at both field strengths. At 7T, two cases revealed better detail detectability in the TrueFISP, and better contrast in the HASTE. Susceptibility artifacts and B1 inhomogeneities were significantly increased at 7T. This study provides first insights into NE ultra-high field MRI of the small bowel and may be considered an important step towards high quality T2w abdominal imaging at 7T MRI. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Perforating arteries originating from the posterior communicating artery: a 7.0-Tesla MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Conijn, Mandy M.A.; Hendrikse, Jeroen; Takahara, Taro; Mali, Willem P.T.M. [University Medical Center Utrecht, Department of Radiology (Hp E 01.132), P.O. Box 85500, Utrecht (Netherlands); Zwanenburg, Jaco J.M. [University Medical Center Utrecht, Image Sciences Institute, Utrecht (Netherlands); Geerlings, Mirjam I. [University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht (Netherlands); Luijten, Peter R. [University Medical Center Utrecht, Department of Radiology (Hp E 01.132), P.O. Box 85500, Utrecht (Netherlands); University Medical Center Utrecht, Image Sciences Institute, Utrecht (Netherlands)

    2009-12-15

    The aim of this study was to investigate the ability of time-of-flight (TOF) magnetic resonance (MR) angiography at 7.0 Tesla to show the perforating branches of the posterior communicating artery (PCoA), and to investigate the presence of such visible perforating branches in relation to the size of the feeding PCoA. The secondary aim was to visualise and describe the anterior choroidal artery and the perforating branches of the P1-segment of posterior cerebral artery (P1). Forty-six healthy volunteers underwent TOF MR angiography at 7.0 Tesla. With 7.0-Tesla imaging, we visualised for the first time perforating arteries originating from the PCoA in vivo without the use of contrast agents. A perforating artery from the PCoA was found in a large proportion of the PCoAs (64%). The presence was associated with a larger diameter of the underlying PCoA (1.23 versus 1.06 mm, P = 0.03). The anterior choroidal artery was visible bilaterally in all participants. In 83% of all P1s, one or two perforating branches were visible. Non-invasive assessment of the perforating arteries of the PCoA together with the anterior choroidal artery and the perforating arteries of the P1 may increase our understanding of infarcts in the deep brain structures supplied by these arteries. (orig.)

  19. Perforating arteries originating from the posterior communicating artery: a 7.0-Tesla MRI study

    International Nuclear Information System (INIS)

    Conijn, Mandy M.A.; Hendrikse, Jeroen; Takahara, Taro; Mali, Willem P.T.M.; Zwanenburg, Jaco J.M.; Geerlings, Mirjam I.; Luijten, Peter R.

    2009-01-01

    The aim of this study was to investigate the ability of time-of-flight (TOF) magnetic resonance (MR) angiography at 7.0 Tesla to show the perforating branches of the posterior communicating artery (PCoA), and to investigate the presence of such visible perforating branches in relation to the size of the feeding PCoA. The secondary aim was to visualise and describe the anterior choroidal artery and the perforating branches of the P1-segment of posterior cerebral artery (P1). Forty-six healthy volunteers underwent TOF MR angiography at 7.0 Tesla. With 7.0-Tesla imaging, we visualised for the first time perforating arteries originating from the PCoA in vivo without the use of contrast agents. A perforating artery from the PCoA was found in a large proportion of the PCoAs (64%). The presence was associated with a larger diameter of the underlying PCoA (1.23 versus 1.06 mm, P = 0.03). The anterior choroidal artery was visible bilaterally in all participants. In 83% of all P1s, one or two perforating branches were visible. Non-invasive assessment of the perforating arteries of the PCoA together with the anterior choroidal artery and the perforating arteries of the P1 may increase our understanding of infarcts in the deep brain structures supplied by these arteries. (orig.)

  20. Perforating arteries originating from the posterior communicating artery: a 7.0-Tesla MRI study.

    Science.gov (United States)

    Conijn, Mandy M A; Hendrikse, Jeroen; Zwanenburg, Jaco J M; Takahara, Taro; Geerlings, Mirjam I; Mali, Willem P Th M; Luijten, Peter R

    2009-12-01

    The aim of this study was to investigate the ability of time-of-flight (TOF) magnetic resonance (MR) angiography at 7.0 Tesla to show the perforating branches of the posterior communicating artery (PCoA), and to investigate the presence of such visible perforating branches in relation to the size of the feeding PCoA. The secondary aim was to visualise and describe the anterior choroidal artery and the perforating branches of the P1-segment of posterior cerebral artery (P1). Forty-six healthy volunteers underwent TOF MR angiography at 7.0 Tesla. With 7.0-Tesla imaging, we visualised for the first time perforating arteries originating from the PCoA in vivo without the use of contrast agents. A perforating artery from the PCoA was found in a large proportion of the PCoAs (64%). The presence was associated with a larger diameter of the underlying PCoA (1.23 versus 1.06 mm, P = 0.03). The anterior choroidal artery was visible bilaterally in all participants. In 83% of all P1s, one or two perforating branches were visible. Non-invasive assessment of the perforating arteries of the PCoA together with the anterior choroidal artery and the perforating arteries of the P1 may increase our understanding of infarcts in the deep brain structures supplied by these arteries.

  1. Design and Fabrication Study on the TESLA500 Superconducting Magnet Package

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Tabares, L.; Toral, F.; Calero, J.; Abramian, P.; Iturbe, R.; Etxeandia, J.; Lucia, C.; Landete, R.; Gomez, J.

    2001-07-01

    An international collaboration at DESY is currently studying the possibilities of a new type of particle accelerator: the superconducting linear collider (1). Developed under the project name TESLA, which stands for TeV Energy Superconducting Linear Accelerator, the facility would be placed in a 33 km long tunnel and would work at the energy range of 0.5 to 0.8 TeV. TESLA opens up new horizons not only as a particle accelerator because it can be also used to generate laser-type X-ray beams: the accelerated electrons would be guided through a refined system of magnetic fields to form a Free Electron Laser (FEL). This study is about one of the components of the accelerator: the magnet package. A technical design of this device and a cost estimate of the series production have been performed. The present report should be understood as a Spanish contribution to the TESLA project. The study has been lead by CIEMAT (Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas) [2], and several Spanish companies have also been involved: ANTEC, JEMA and INGOVI. Special thanks are given to the Oficina de Ciencia y Tecnologia, which has granted this work. (Author) 16 refs.

  2. Optimization of materials for the parts that compose a Tesla turbine

    International Nuclear Information System (INIS)

    Rocha, Geovana Vilas Boas da; Guimaraes, Lamartine N.F.; Placco, Guilherme M.

    2013-01-01

    The TERRA project (Tecnologia de Reatores Rapidos Avancados) of the Aeronautica (Brazil) aims to develop the necessary technologies for the design of nuclear microreactors. These, in turn, aim to address the thermal and electrical needs in space vehicles. One of the activities of this project is to build a closed thermal cycle, the Rankine type in order to test a Tesla turbine type developed by the group. In this thermodynamic cycle the water is transformed into steam, which triggers a turbine which, in turn, provide power to the alternator to be converted into electricity. The work presented a survey of the materials available on the national market for machining a Tesla type turbine. The surveys were made considering the characteristics and operating conditions of a specific thermal cycle, the interest of the group. Results: cost-benefit tables for each party of the turbine, characteristics of each material, the machining process, as well as a comparison between one of 304L stainless steel model turbine with a turbine with the selected materials. The results from this study raised the level of sophistication of the research involved the TERRA project, since the study of ideal materials that make up the parts of a Tesla type turbine in a heat cycle is unprecedented

  3. Cortical Cerebral Microinfarcts on 3 Tesla MRI in Patients with Vascular Cognitive Impairment.

    Science.gov (United States)

    Ferro, Doeschka A; van Veluw, Susanne J; Koek, Huiberdina L; Exalto, Lieza G; Biessels, Geert Jan

    2017-01-01

    Cerebral microinfarcts (CMIs) are small ischemic lesions that are a common neuropathological finding in patients with stroke or dementia. CMIs in the cortex can now be detected in vivo on 3 Tesla MRI. To determine the occurrence of CMIs and associated clinical features in patients with possible vascular cognitive impairment (VCI). 182 memory-clinic patients (mean age 71.4±10.6, 55% male) with vascular injury on brain MRI (i.e., possible VCI) underwent a standardized work-up including 3 Tesla MRI and cognitive assessment. A control group consisted of 70 cognitively normal subjects (mean age 70.6±4.7, 60% male). Cortical CMIs and other neuroimaging markers of vascular brain injury were rated according to established criteria. Occurrence of CMIs was higher (20%) in patients compared to controls (10%). Among patients, the presence of CMIs was associated with male sex, history of stroke, infarcts, and white matter hyperintensities. CMI presence was also associated with a diagnosis of vascular dementia and reduced performance in multiple cognitive domains. CMIs on 3 Tesla MRI are common in patients with possible VCI and co-occur with imaging markers of small and large vessel disease, likely reflecting a heterogeneous etiology. CMIs are associated with worse cognitive performance, independent of other markers of vascular brain injury.

  4. Prospects for 6- to 10-Tesla magnets for a Tevatron upgrade

    International Nuclear Information System (INIS)

    Mantsch, P.M.

    1989-01-01

    This paper reports on prospects for 6- to 10-tesla magnets for a Teratron upgrade. The first SSC physics is at least 10 years away. An upgrade of the Fermilab Tevatron will ensure the continuity of a vigorous high-energy physics program until the SSC turns on. Three basic proposals are under consideration: (1) bar pp at 3 x 10 31 --Increase luminosity by improvements to the bar p source. (2) p bar p at 1 TeV and 2 x 10 32 --Move the main ring to a new tunnel, build a second Tevatron ring. (3) bar pp > 1.5 TeV and 7 x 10 30 --Replace the Tevatron with a higher energy ring. The last two options require new higher-field magnets. The second option requires about a hundred 6.6-tesla dipoles in addition to a ring of Tevatron-strength (4.4-T) magnets. These higher-field magnets are necessary in both rings to lengthen the straight sections in order to realize the collision optics. The third option requires a ring of magnets of 6.6 T or slightly higher to replace the present Tevatron plus a number of special 8- to 9-tesla magnets

  5. An 8-GW long-pulse generator based on Tesla transformer and pulse forming network.

    Science.gov (United States)

    Su, Jiancang; Zhang, Xibo; Li, Rui; Zhao, Liang; Sun, Xu; Wang, Limin; Zeng, Bo; Cheng, Jie; Wang, Ying; Peng, Jianchang; Song, Xiaoxin

    2014-06-01

    A long-pulse generator TPG700L based on a Tesla transformer and a series pulse forming network (PFN) is constructed to generate intense electron beams for the purpose of high power microwave (HPM) generation. The TPG700L mainly consists of a 12-stage PFN, a built-in Tesla transformer in a pulse forming line, a three-electrode gas switch, a transmission line with a trigger, and a load. The Tesla transformer and the compact PFN are the key technologies for the development of the TPG700L. This generator can output electrical pulses with a width as long as 200 ns at a level of 8 GW and a repetition rate of 50 Hz. When used to drive a relative backward wave oscillator for HPM generation, the electrical pulse width is about 100 ns on a voltage level of 520 kV. Factors affecting the pulse waveform of the TPG700L are also discussed. At present, the TPG700L performs well for long-pulse HPM generation in our laboratory.

  6. Focused tight dressing does not prevent cochlear implant magnet migration under 1.5 Tesla MRI.

    Science.gov (United States)

    Cuda, D; Murri, A; Succo, G

    2013-04-01

    We report a retrospective case of inner magnet migration, which occurred after 1.5 Tesla MRI scanning in an adult recipient of a bilateral cochlear implant (CI) despite a focused head dressing. The patient, bilaterally implanted with Nucleus 5 CIs (Cochlear LTD, Sydney, Australia), underwent a 1.5 Tesla cholangio-MRI scan for biliary duct pathology. In subsequent days, a focal skin alteration appeared over the left inner coil. Plain skull radiographs showed partial magnet migration on the left side. Surgical exploration confirmed magnet twisting; the magnet was effectively repositioned. Left CI performance was restored to pre-migration level. The wound healed without complications. Thus, focused dressing does not prevent magnet migration in CI recipients undergoing 1.5 Tesla MRI. All patients should be counselled on this potential complication. A minor surgical procedure is required to reposition the magnet. Nevertheless, timely diagnosis is necessary to prevent skin breakdown and subsequent device contamination. Plain skull radiograph is very effective in identifying magnet twisting; it should be performed systematically after MRI or minimally on all suspected cases.

  7. An 8-GW long-pulse generator based on Tesla transformer and pulse forming network

    Energy Technology Data Exchange (ETDEWEB)

    Su, Jiancang; Zhang, Xibo; Li, Rui; Zhao, Liang, E-mail: zhaoliang0526@163.com; Sun, Xu; Wang, Limin; Zeng, Bo; Cheng, Jie; Wang, Ying; Peng, Jianchang; Song, Xiaoxin [Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi' an, Shaanxi 710024 (China)

    2014-06-15

    A long-pulse generator TPG700L based on a Tesla transformer and a series pulse forming network (PFN) is constructed to generate intense electron beams for the purpose of high power microwave (HPM) generation. The TPG700L mainly consists of a 12-stage PFN, a built-in Tesla transformer in a pulse forming line, a three-electrode gas switch, a transmission line with a trigger, and a load. The Tesla transformer and the compact PFN are the key technologies for the development of the TPG700L. This generator can output electrical pulses with a width as long as 200 ns at a level of 8 GW and a repetition rate of 50 Hz. When used to drive a relative backward wave oscillator for HPM generation, the electrical pulse width is about 100 ns on a voltage level of 520 kV. Factors affecting the pulse waveform of the TPG700L are also discussed. At present, the TPG700L performs well for long-pulse HPM generation in our laboratory.

  8. Design and Fabrication Study on the TESLA500 Superconducting Magnet Package

    International Nuclear Information System (INIS)

    Garcia-Tabares, L.; Toral, F.; Calero, J.; Abramian, P.; Iturbe, R.; Etxeandia, J.; Lucia, C.; Landete, R.; Gomez, J.

    2001-01-01

    An international collaboration at DESY is currently studying the possibilities of a new type of particle accelerator: the superconducting linear collider (1). Developed under the project name TESLA, which stands for TeV Energy Superconducting Linear Accelerator, the facility would be placed in a 33 km long tunnel and would work at the energy range of 0.5 to 0.8 TeV. TESLA opens up new horizons not only as a particle accelerator because it can be also used to generate laser-type X-ray beams: the accelerated electrons would be guided through a refined system of magnetic fields to form a Free Electron Laser (FEL). This study is about one of the components of the accelerator: the magnet package. A technical design of this device and a cost estimate of the series production have been performed. The present report should be understood as a Spanish contribution to the TESLA project. The study has been lead by CIEMAT (Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas) [2], and several Spanish companies have also been involved: ANTEC, JEMA and INGOVI. Special thanks are given to the Oficina de Ciencia y Tecnologia, which has granted this work. (Author) 16 refs

  9. Voltage distribution in tapered winding of tesla-transformer during discharge process of PFL

    International Nuclear Information System (INIS)

    Xin Jiaqi; Chang Anbi; Li Mingjia; Kang Qiang

    2007-01-01

    The operation principle of integral construction of Tesla transformer and PFL was investigated in Tesla-transformer-type accelerator. Experiment was carried out on Tesla transformer's secondary winding to study the impulse voltage distribution while PFL was discharging. The regularities of turn-ground voltage distribution and interturn voltage distribution were summarized. Voltage distribution within PFL was calculated and it was compared with the experimental result. Structural winding of parallel coils in the head, parallel coils in the end and shading ring were used to improve voltage distribution and that was testified by experiment. The results indicate that taper winding doesn't effect electric field within PFL, the turn-ground voltage appears linearly, the interturn voltage fluctuates seriously and it is the biggest in head of winding. The three optimized methods help to depress oscillation, the structural winding of parallel coils in the head decreases the interturn voltage in head of winding remark-ably and the parallel coils in the end decrease the interturn voltage in the end. (authors)

  10. MR cholangiopancreatography. Comparison of images obtained with 1.0 and 1.5 tesla units

    International Nuclear Information System (INIS)

    Yasui, Masayasu; Ito, Katsuyoshi; Koike, Shinji; Matsunaga, Naofumi

    2002-01-01

    The purpose of this study was to compare the image quality and visualization obtained in MR cholangiopancreatography (MRCP) using different high-field strength (1.0 vs. 1.5 Tesla) MR units and to assess the effect of field strength on MRCP. This study population included 10 healthy volunteers and 37 patients suspected of having pancreatobiliary diseases. MRCP images were obtained using two MR units with different high-field strengths (1.0 and 1.5 Tesla), with half-Fourier acquisition single-shot turbo spin-echo (HASTE) and rapid acquisition by relaxation enhancement (RARE) sequences. The image quality and visualization of each portion of the pancreatobiliary system were graded and recorded using a four-point scale. Additionally, the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured. The SNR and CNR in HASTE sequences acquired with the 1.5 Tesla (T) unit were significantly higher than those acquired with the 1.0 T unit (p=0.001). In qualitative analysis, there were no statistically significant differences in image quality or visualization of the ducts in either HASTE or RARE sequences between 1.0 T and 1.5 T. Our study showed that visual image quality provided by MRCP was equivalent at 1.0 and 1.5 T. (author)

  11. A 4-Tesla superconducting whole-body magnet for MR imaging and spectroscopy

    International Nuclear Information System (INIS)

    Vetter, J.; Ries, G.; Reichert, T.

    1988-01-01

    Since January 87 a 4 tesla MR magnet with a 1.25 m diameter warm bore is in operation at the Siemens Research Laboratories. The magnet weighing 10 tons is part of a whole-body MR device devoted to in-vivo research studies at magnetic fields significantly higher than 2 tesla; the highest field strength presently used in standard MR whole-body systems. The stored energy of the adiabatically stable six-coil system is 39 MJ at 4 tesla. The rated current is 376 A. Superconducting and resistive shim-coils together with iron shims reduce the bare magnet inhomogeneity of 100 ppm down to less than 5 ppm in a 50 cm diameter spherical volume. The magnet operates in persistent mode with the current leads retracted. The field drift is less than 3 x 10/sup -8//h. A small helium refrigerator is used to cool both the two radiation shields of the cryostat and the current leads and to reliquify the evaporating helium gas. Results of coil design, analysis of forces and stresses, quench protection, cryostat design and magnet operation are reported

  12. A semi-automated algorithm for hypothalamus volumetry in 3 Tesla magnetic resonance images.

    Science.gov (United States)

    Wolff, Julia; Schindler, Stephanie; Lucas, Christian; Binninger, Anne-Sophie; Weinrich, Luise; Schreiber, Jan; Hegerl, Ulrich; Möller, Harald E; Leitzke, Marco; Geyer, Stefan; Schönknecht, Peter

    2018-07-30

    The hypothalamus, a small diencephalic gray matter structure, is part of the limbic system. Volumetric changes of this structure occur in psychiatric diseases, therefore there is increasing interest in precise volumetry. Based on our detailed volumetry algorithm for 7 Tesla magnetic resonance imaging (MRI), we developed a method for 3 Tesla MRI, adopting anatomical landmarks and work in triplanar view. We overlaid T1-weighted MR images with gray matter-tissue probability maps to combine anatomical information with tissue class segmentation. Then, we outlined regions of interest (ROIs) that covered potential hypothalamus voxels. Within these ROIs, seed growing technique helped define the hypothalamic volume using gray matter probabilities from the tissue probability maps. This yielded a semi-automated method with short processing times of 20-40 min per hypothalamus. In the MRIs of ten subjects, reliabilities were determined as intraclass correlations (ICC) and volume overlaps in percent. Three raters achieved very good intra-rater reliabilities (ICC 0.82-0.97) and good inter-rater reliabilities (ICC 0.78 and 0.82). Overlaps of intra- and inter-rater runs were very good (≥ 89.7%). We present a fast, semi-automated method for in vivo hypothalamus volumetry in 3 Tesla MRI. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. Assessment of MRI Issues at 3 Tesla for a New Metallic Tissue Marker

    Science.gov (United States)

    Cronenweth, Charlotte M.; Shellock, Frank G.

    2015-01-01

    Purpose. To assess the MRI issues at 3 Tesla for a metallic tissue marker used to localize removal areas of tissue abnormalities. Materials and Methods. A newly designed, metallic tissue marker (Achieve Marker, CareFusion, Vernon Hills, IL) used to mark biopsy sites, particularly in breasts, was assessed for MRI issues which included standardized tests to determine magnetic field interactions (i.e., translational attraction and torque), MRI-related heating, and artifacts at 3 Tesla. Temperature changes were determined for the marker using a gelled-saline-filled phantom. MRI was performed at a relatively high specific absorption rate (whole body averaged SAR, 2.9-W/kg). MRI artifacts were evaluated using T1-weighted, spin echo and gradient echo pulse sequences. Results. The marker displayed minimal magnetic field interactions (2-degree deflection angle and no torque). MRI-related heating was only 0.1°C above background heating (i.e., the heating without the tissue marker present). Artifacts seen as localized signal loss were relatively small in relation to the size and shape of the marker. Conclusions. Based on the findings, the new metallic tissue marker is acceptable or “MR Conditional” (using current labeling terminology) for a patient undergoing an MRI procedure at 3 Tesla or less. PMID:26266051

  14. Myocardial lipid content in Fabry disease: a combined 1H-MR spectroscopy and MR imaging study at 3 Tesla.

    Science.gov (United States)

    Petritsch, B; Köstler, H; Weng, A M; Horn, M; Gassenmaier, T; Kunz, A S; Weidemann, F; Wanner, C; Bley, T A; Beer, M

    2016-10-28

    Fabry disease is characterized by a progressive deposition of sphingolipids in different organ systems, whereby cardiac involvement leads to death. We hypothesize that lysosomal storage of sphingolipids in the heart as occurring in Fabry disease does not reflect in higher cardiac lipid concentrations detectable by 1 H magnetic resonance spectroscopy (MRS) at 3 Tesla. Myocardial lipid content was quantified in vivo by 1 H-MRS in 30 patients (12 male, 18 female; 18 patients treated with enzyme replacement therapy) with genetically proven Fabry disease and in 30 healthy controls. The study protocol combined 1 H-MRS with cardiac cine imaging and LGE MRI in a single examination. Myocardial lipid content was not significantly elevated in Fabry disease (p = 0.225). Left ventricular (LV) mass was significantly higher in patients suffering from Fabry disease compared to controls (p = 0.019). Comparison of patients without signs of myocardial fibrosis in MRI (LGE negative; n = 12) to patients with signs of fibrosis (LGE positive; n = 18) revealed similar myocardial lipid content in both groups (p > 0.05), while the latter showed a trend towards elevated LV mass (p = 0.076). This study demonstrates the potential of lipid metabolic investigation embedded in a comprehensive examination of cardiac morphology and function in Fabry disease. There was no evidence that lysosomal storage of sphingolipids influences cardiac lipid content as measured by 1 H-MRS. Finally, the authors share the opinion that a comprehensive cardiac examination including three subsections (LGE; 1 H-MRS; T 1 mapping), could hold the highest potential for the final assessment of early and late myocardial changes in Fabry disease.

  15. Diffusion-weighted MR imaging of the normal pancreas: reproducibility and variations of apparent diffusion coefficient measurement at 1.5- and 3.0-Tesla.

    Science.gov (United States)

    Barral, M; Soyer, P; Ben Hassen, W; Gayat, E; Aout, M; Chiaradia, M; Rahmouni, A; Luciani, A

    2013-04-01

    To evaluate reproducibility and variations in apparent diffusion coefficient (ADC) measurement in normal pancreatic parenchyma at 1.5- and 3.0-Tesla and determine if differences may exist between the four pancreatic segments. Diffusion-weighted MR imaging of the pancreas was performed at 1.5-Tesla in 20 patients and at 3.0-Tesla in other 20 patients strictly matched for gender and age using the same b values (0, 400 and 800s/mm(2)). Two independent observers placed regions of interest within the four pancreatic segments to measure ADC at both fields. Intra- and inter-observer agreement in ADC measurement was assessed using Bland-Altman analysis and comparison between ADC values obtained at both fields using non-parametrical tests. There were no significant differences in ADC between repeated measurements and between ADC obtained at 1.5-Tesla and those at 3.0-Tesla. The 95% limits of intra-observer agreement between ADC were 2.3%-22.7% at 1.5-Tesla and 1%-24.2% at 3.0-Tesla and those for inter-observer agreement between 1.9%-14% at 1.5-Tesla and 8%-25% at 3.0-Tesla. ADC values were similar in all pancreatic segments at 3.0-T whereas the tail had lower ADC at 1.5-Tesla. ADC measurement conveys high degrees of intra- and inter-observer reproducibility. ADC have homogeneous distribution among the four pancreatic segments at 3.0-Tesla. Copyright © 2012 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.

  16. 3 tesla magnetic resonance imaging in children and adults with congenital heart disease; 3-Tesla-Magnetresonanztomographie zur Untersuchung von Kindern und Erwachsenen mit angeborenen Herzfehlern

    Energy Technology Data Exchange (ETDEWEB)

    Voges, I.; Hart, C.; Kramer, H.H.; Rickers, C. [Universitaetsklinikum Schleswig-Holstein, Klinik fuer angeborene Herzfehler und Kinderkardiologie, Kiel (Germany); Jerosch-Herold, M. [Harvard Medical School, Department of Radiology, Brigham and Women' s Hospital, Boston (United States); Helle, M. [Universitaetsklinikum Schleswig-Holstein, Institut fuer Neuroradiologie, Kiel (Germany)

    2010-09-15

    Cardiovascular magnetic resonance imaging (CMR) has become a routinely used imaging modality for congenital heart disease. A CMR examination allows the assessment of thoracic anatomy, global and regional cardiac function, blood flow in the great vessels and myocardial viability and perfusion. In the clinical routine cardiovascular MRI is mostly performed at field strengths of 1.5 Tesla (T). Recently, magnetic resonance systems operating at a field strengths of 3 T became clinically available and can also be used for cardiovascular MRI. The main advantage of CMR at 3 T is the gain in the signal-to-noise ratio resulting in improved image quality and/or allowing higher acquisition speed. Several further differences compared to MRI systems with lower field strengths have to be considered for practical applications. This article describes the impact of CMR at 3 T in patients with congenital heart disease by meanings of methodical considerations and case studies. (orig.) [German] Die kardiovaskulaere Magnetresonanztomographie (MRT) hat sich zu einer etablierten bildgebenden Methode zur Untersuchung von Patienten mit angeborenen Herzfehlern entwickelt. Sie erlaubt in einer einzigen Untersuchung die exakte Beurteilung von Anatomie, globaler und regionaler Funktion, Blutfluessen sowie der myokardialen Perfusion und Vitalitaet. In der klinischen Routine erfolgen die Untersuchungen zumeist bei einer Feldstaerke von 1,5 Tesla (T), mittlerweile gibt es jedoch Geraete und Bildgebungstechniken, die die kardiovaskulaere MRT auch bei 3 T ermoeglichen. Der wesentliche Vorteil der MRT bei 3 T ist das hoehere Signal-zu-Rausch-Verhaeltnis, das sowohl zu einer Verbesserung der Bildqualitaet als auch zu einer Verkuerzung der Untersuchungszeit genutzt werden kann. Darueber hinaus bestehen verschiedene andere Unterschiede gegenueber Systemen mit niedriger Feldstaerke, die im praktischen Einsatz beachtet werden muessen. Dieser Artikel beschreibt die Erfahrungen der 3-T-MRT fuer die

  17. Assessment of the cervical spine denticulate ligament using MRI volumetric sequence: Comparison between 1.5 Tesla and 3.0 Tesla.

    Science.gov (United States)

    Seragioli, Rafael; Simao, Marcelo Novelino; Simao, Gustavo Novelino; Herrero, Carlos Fernando P S; Nogueira-Barbosa, Marcello H

    2018-03-01

    Denticulate ligaments (DLs) are pial extensions on each side of the spinal cord, comprising about 20 to 21 pairs of fibrous structures connecting the dura mater to the spinal cord. These ligaments are significant anatomical landmarks in the surgical approach to intradural structures. To our knowledge, there is no previous study on the detection of DLs using MRI. After IRB approval, we retrospectively evaluated 116 consecutive MRI scans of the cervical spine, using the volumetric sequence 3D COSMIC, 65 and 51 studies with 1.5T and 3.0T respectively. We did not include trauma and tumor cases. Two independent radiologists assessed the detection of cervical spine DLs independently and blinded for each cervical vertebral level. We compared the frequency of detection of these ligaments in 1.5 Tesla and 3.0 Tesla MRI using Fisher exact test considering P<0.05 as significant. We evaluated interobserver agreement with Kappa coefficient. We observed high detection frequency of the cervical spine DLs using both 1.5T (70 to 91%) and 3.0T (68 to 98%). We found no statistically significant difference in the detection frequency of ligaments between the 1.5T and 3.0T MRI in all vertebral levels. Using 3.0T, radiologists identified ligaments better in higher vertebral levels than for lower cervical levels (P=0.0003). Interobserver agreement on the identification of DL was poor both for 1.5T (k=0.3744; CI 95% 0.28-0.46) and 3.0T (k=0.3044; CI 95% 0.18-0.42) MRI. Radiologists identified most of the cervical DLs using volumetric MRI acquisition. Our results suggest 1.5T and 3.0T MRI performed similarly in the detection of DLs. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  18. SU-F-J-166: Volumetric Spatial Distortions Comparison for 1.5 Tesla Versus 3 Tesla MRI for Gamma Knife Radiosurgery Scans Using Frame Marker Fusion and Co-Registration Modes

    International Nuclear Information System (INIS)

    Neyman, G

    2016-01-01

    Purpose: To compare typical volumetric spatial distortions for 1.5 Tesla versus 3 Tesla MRI Gamma Knife radiosurgery scans in the frame marker fusion and co-registration frame-less modes. Methods: Quasar phantom by Modus Medical Devices Inc. with GRID image distortion software was used for measurements of volumetric distortions. 3D volumetric T1 weighted scans of the phantom were produced on 1.5 T Avanto and 3 T Skyra MRI Siemens scanners. The analysis was done two ways: for scans with localizer markers from the Leksell frame and relatively to the phantom only (simulated co-registration technique). The phantom grid contained a total of 2002 vertices or control points that were used in the assessment of volumetric geometric distortion for all scans. Results: Volumetric mean absolute spatial deviations relatively to the frame localizer markers for 1.5 and 3 Tesla machine were: 1.39 ± 0.15 and 1.63 ± 0.28 mm with max errors of 1.86 and 2.65 mm correspondingly. Mean 2D errors from the Gamma Plan were 0.3 and 1.0 mm. For simulated co-registration technique the volumetric mean absolute spatial deviations relatively to the phantom for 1.5 and 3 Tesla machine were: 0.36 ± 0.08 and 0.62 ± 0.13 mm with max errors of 0.57 and 1.22 mm correspondingly. Conclusion: Volumetric spatial distortions are lower for 1.5 Tesla versus 3 Tesla MRI machines localized with markers on frames and significantly lower for co-registration techniques with no frame localization. The results show the advantage of using co-registration technique for minimizing MRI volumetric spatial distortions which can be especially important for steep dose gradient fields typically used in Gamma Knife radiosurgery. Consultant for Elekta AB

  19. SU-F-J-166: Volumetric Spatial Distortions Comparison for 1.5 Tesla Versus 3 Tesla MRI for Gamma Knife Radiosurgery Scans Using Frame Marker Fusion and Co-Registration Modes

    Energy Technology Data Exchange (ETDEWEB)

    Neyman, G [The Cleveland Clinic Foundation, Cleveland, OH (United States)

    2016-06-15

    Purpose: To compare typical volumetric spatial distortions for 1.5 Tesla versus 3 Tesla MRI Gamma Knife radiosurgery scans in the frame marker fusion and co-registration frame-less modes. Methods: Quasar phantom by Modus Medical Devices Inc. with GRID image distortion software was used for measurements of volumetric distortions. 3D volumetric T1 weighted scans of the phantom were produced on 1.5 T Avanto and 3 T Skyra MRI Siemens scanners. The analysis was done two ways: for scans with localizer markers from the Leksell frame and relatively to the phantom only (simulated co-registration technique). The phantom grid contained a total of 2002 vertices or control points that were used in the assessment of volumetric geometric distortion for all scans. Results: Volumetric mean absolute spatial deviations relatively to the frame localizer markers for 1.5 and 3 Tesla machine were: 1.39 ± 0.15 and 1.63 ± 0.28 mm with max errors of 1.86 and 2.65 mm correspondingly. Mean 2D errors from the Gamma Plan were 0.3 and 1.0 mm. For simulated co-registration technique the volumetric mean absolute spatial deviations relatively to the phantom for 1.5 and 3 Tesla machine were: 0.36 ± 0.08 and 0.62 ± 0.13 mm with max errors of 0.57 and 1.22 mm correspondingly. Conclusion: Volumetric spatial distortions are lower for 1.5 Tesla versus 3 Tesla MRI machines localized with markers on frames and significantly lower for co-registration techniques with no frame localization. The results show the advantage of using co-registration technique for minimizing MRI volumetric spatial distortions which can be especially important for steep dose gradient fields typically used in Gamma Knife radiosurgery. Consultant for Elekta AB.

  20. Oxygen-enhanced MRI of the lungs. Intraindividual comparison between 1.5 and 3 Tesla

    International Nuclear Information System (INIS)

    Dietrich, Olaf; Thieme, S.F.; Maxien, D.; Nikolaou, K.; Reiser, M.; Schoenberg, S.O.; Fink, C.

    2011-01-01

    Purpose: To assess the feasibility of oxygen-enhanced MRI of the lung at 3 Tesla and to compare signal characteristics with 1.5 Tesla. Materials and Methods: 13 volunteers underwent oxygen-enhanced lung MRI at 1.5 and 3 T with a T 1-weighted single-slice non-selective inversion-recovery single-shot half-Fourier fast-spin-echo sequence with simultaneous respiratory and cardiac triggering in coronal orientation. 40 measurements were acquired during room air breathing and subsequently during oxygen breathing (15 L/min, close-fitting face-mask). The signal-to-noise ratio (SNR) of the lung tissue was determined with a difference image method. The image quality of all acquisitions was visually assessed. The mean values of the oxygen-induced relative signal enhancement and its regional coefficient of variation were calculated and the signal enhancement was displayed as color-coded parameter maps. Oxygen-enhancement maps were visually assessed with respect to the distribution and heterogeneity of the oxygen-related signal enhancement at both field strengths. Results: The mean relative signal enhancement due to oxygen breathing was 13 % (± 5.6 %) at 1.5 T and of 9.0 % (± 8.0 %) at 3 T. The regional coefficient of variation was significantly higher at 3 T. Visual and quantitative assessment of the enhancement maps showed considerably less homogeneous distribution of the signal enhancement at 3 T. The SNR was not significantly different but showed a trend to slightly higher values (increase of about 10 %) at 3 T. Conclusion: Oxygen-enhanced pulmonary MRI is feasible at 3 Tesla. However, signal enhancement is currently more heterogeneous and slightly lower at 3 T. (orig.)

  1. Can magnetic resonance imaging at 3.0-Tesla reliably detect patients with endometriosis? Initial results.

    Science.gov (United States)

    Thomeer, Maarten G; Steensma, Anneke B; van Santbrink, Evert J; Willemssen, Francois E; Wielopolski, Piotr A; Hunink, Myriam G; Spronk, Sandra; Laven, Joop S; Krestin, Gabriel P

    2014-04-01

    The aim of this study was to determine whether an optimized 3.0-Tesla magnetic resonance imaging (MRI) protocol is sensitive and specific enough to detect patients with endometriosis. This was a prospective cohort study with consecutive patients. Forty consecutive patients with clinical suspicion of endometriosis underwent 3.0-Tesla MRI, including a T2-weighted high-resolution fast spin echo sequence (spatial resolution=0.75 ×1.2 ×1.5 mm³) and a 3D T1-weighted high-resolution gradient echo sequence (spatial resolution=0.75 ×1.2 × 2.0 mm³). Two radiologists reviewed the dataset with consensus reading. During laparoscopy, which was used as reference standard, all lesions were characterized according to the revised criteria of the American Fertility Society. Patient-level and region-level sensitivities and specificities and lesion-level sensitivities were calculated. Patient-level sensitivity was 42% for stage I (5/12) and 100% for stages II, III and IV (25/25). Patient-level specificity for all stages was 100% (3/3). The region-level sensitivity and specificity was 63% and 97%, respectively. The sensitivity per lesion was 61% (90% for deep lesions, 48% for superficial lesions and 100% for endometriomata). The detection rate of obliteration of the cul-the-sac was 100% (10/10) with no false positive findings. The interreader agreement was substantial to perfect (kappa=1 per patient, 0.65 per lesion and 0.71 for obliteration of the cul-the-sac). An optimized 3.0-Tesla MRI protocol is accurate in detecting stage II to stage IV endometriosis. © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

  2. 3 Tesla MRI-negative focal epilepsies: Presurgical evaluation, postoperative outcome and predictive factors.

    Science.gov (United States)

    Kogias, Evangelos; Klingler, Jan-Helge; Urbach, Horst; Scheiwe, Christian; Schmeiser, Barbara; Doostkam, Soroush; Zentner, Josef; Altenmüller, Dirk-Matthias

    2017-12-01

    To investigate presurgical diagnostic modalities, clinical and seizure outcome as well as predictive factors after resective epilepsy surgery in 3 Tesla MRI-negative focal epilepsies. This retrospective study comprises 26 patients (11 males/15 females, mean age 34±12years, range 13-50 years) with 3 Tesla MRI-negative focal epilepsies who underwent resective epilepsy surgery. Non-invasive and invasive presurgical diagnostic modalities, type and localization of resection, clinical and epileptological outcome with a minimum follow-up of 1year (range 1-11 years, mean 2.5±2.3years) after surgery as well as outcome predictors were evaluated. All patients underwent invasive video-EEG monitoring after implantation of intracerebral depth and/or subdural electrodes. Ten patients received temporal and 16 extratemporal or multilobar (n=4) resections. There was no perioperative death or permanent morbidity. Overall, 12 of 26 patients (46%) were completely seizure-free (Engel IA) and 65% had a favorable outcome (Engel I-II). In particular, seizure-free ratio was 40% in the temporal and 50% in the extratemporal group. In the temporal group, long duration of epilepsy correlated with poor seizure outcome, whereas congruent unilateral FDG-PET hypometabolism correlated with a favorable outcome. In almost two thirds of temporal and extratemporal epilepsies defined as "non-lesional" by 3 Tesla MRI criteria, a favorable postoperative seizure outcome (Engel I-II) can be achieved with accurate multimodal presurgical evaluation including intracranial EEG recordings. In the temporal group, most favorable results were obtained when FDG-PET displayed congruent unilateral hypometabolism. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Noninvasive Assessment of Oxygen Extraction Fraction in Chronic Ischemia Using Quantitative Susceptibility Mapping at 7 Tesla.

    Science.gov (United States)

    Uwano, Ikuko; Kudo, Kohsuke; Sato, Ryota; Ogasawara, Kuniaki; Kameda, Hiroyuki; Nomura, Jun-Ichi; Mori, Futoshi; Yamashita, Fumio; Ito, Kenji; Yoshioka, Kunihiro; Sasaki, Makoto

    2017-08-01

    The oxygen extraction fraction (OEF) is an effective metric to evaluate metabolic reserve in chronic ischemia. However, OEF is considered to be accurately measured only when using positron emission tomography (PET). Thus, we investigated whether OEF maps generated by magnetic resonance quantitative susceptibility mapping (QSM) at 7 Tesla enabled detection of OEF changes when compared with those obtained with PET. Forty-one patients with chronic stenosis/occlusion of the unilateral internal carotid artery or middle cerebral artery were examined using 7 Tesla-MRI and PET scanners. QSM images were obtained from 3-dimensional T2*-weighted images, using a multiple dipole-inversion algorithm. OEF maps were generated based on susceptibility differences between venous structures and brain tissues on QSM images. OEF ratios of the ipsilateral middle cerebral artery territory against the contralateral side were calculated on the QSM-OEF and PET-OEF images, using an anatomic template. The OEF ratio in the middle cerebral artery territory showed significant correlations between QSM-OEF and PET-OEF maps ( r =0.69; P 1.09, as determined by receiver operating characteristic analysis, showed a sensitivity and specificity of 0.82 and 0.86, respectively, for the substantial increase in the PET-OEF ratio. Absolute QSM-OEF values were significantly correlated with PET-OEF values in the patients with increased PET-OEF. OEF ratios on QSM-OEF images at 7 Tesla showed a good correlation with those on PET-OEF images in patients with unilateral steno-occlusive internal carotid artery/middle cerebral artery lesions, suggesting that noninvasive OEF measurement by MRI can be a substitute for PET. © 2017 American Heart Association, Inc.

  4. Value of 3 Tesla diffusion-weighted magnetic resonance imaging for assessing liver fibrosis.

    Science.gov (United States)

    Papalavrentios, Lavrentios; Sinakos, Emmanouil; Chourmouzi, Danai; Hytiroglou, Prodromos; Drevelegas, Konstantinos; Constantinides, Manos; Drevelegas, Antonios; Talwalkar, Jayant; Akriviadis, Evangelos

    2015-01-01

    Limited data are available regarding the role of magnetic resonance imaging (MRI), particularly the new generation 3 Tesla technology, and especially diffusion-weighted imaging (DWI) in predicting liver fibrosis. The aim of our pilot study was to assess the clinical performance of the apparent diffusion coefficient (ADC) of liver parenchyma for the assessment of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). 18 patients with biopsy-proven NAFLD underwent DWI with 3 Tesla MRI. DWI was performed with single-shot echo-planar technique at b values of 0-500 and 0-1000 s/mm 2 . ADC was measured in four locations in the liver and the mean ADC value was used for analysis. Staging of fibrosis was performed according to the METAVIR system. The median age of patients was 52 years (range 23-73). The distribution of patients in different fibrosis stages was: 0 (n=1), 1 (n=7), 2 (n=1), 3 (n=5), 4 (n=4). Fibrosis stage was poorly associated with ADC at b value of 0-500 s/mm 2 (r= -0.30, P=0.27). However it was significantly associated with ADC at b value of 0-1000 s/mm 2 (r= -0.57, P=0.01). For this b value (0-1000 s/mm 2 ) the area under receiver-operating characteristic curve was 0.93 for fibrosis stage ≥3 and the optimal ADC cut-off value was 1.16 ×10 -3 mm 2 /s. 3 Tesla DWI can possibly predict the presence of advanced fibrosis in patients with NAFLD.

  5. Comparison of Deep Brain Stimulation Lead Targeting Accuracy and Procedure Duration between 1.5- and 3-Tesla Interventional Magnetic Resonance Imaging Systems: An Initial 12-Month Experience.

    Science.gov (United States)

    Southwell, Derek G; Narvid, Jared A; Martin, Alastair J; Qasim, Salman E; Starr, Philip A; Larson, Paul S

    2016-01-01

    Interventional magnetic resonance imaging (iMRI) allows deep brain stimulator lead placement under general anesthesia. While the accuracy of lead targeting has been described for iMRI systems utilizing 1.5-tesla magnets, a similar assessment of 3-tesla iMRI procedures has not been performed. To compare targeting accuracy, the number of lead targeting attempts, and surgical duration between procedures performed on 1.5- and 3-tesla iMRI systems. Radial targeting error, the number of targeting attempts, and procedure duration were compared between surgeries performed on 1.5- and 3-tesla iMRI systems (SmartFrame and ClearPoint systems). During the first year of operation of each system, 26 consecutive leads were implanted using the 1.5-tesla system, and 23 consecutive leads were implanted using the 3-tesla system. There was no significant difference in radial error (Mann-Whitney test, p = 0.26), number of lead placements that required multiple targeting attempts (Fisher's exact test, p = 0.59), or bilateral procedure durations between surgeries performed with the two systems (p = 0.15). Accurate DBS lead targeting can be achieved with iMRI systems utilizing either 1.5- or 3-tesla magnets. The use of a 3-tesla magnet, however, offers improved visualization of the target structures and allows comparable accuracy and efficiency of placement at the selected targets. © 2016 S. Karger AG, Basel.

  6. Tissue expander stimulated lengthening of arteries (TESLA) induces early endothelial cell proliferation in a novel rodent model.

    Science.gov (United States)

    Potanos, Kristina; Fullington, Nora; Cauley, Ryan; Purcell, Patricia; Zurakowski, David; Fishman, Steven; Vakili, Khashayar; Kim, Heung Bae

    2016-04-01

    We examine the mechanism of aortic lengthening in a novel rodent model of tissue expander stimulated lengthening of arteries (TESLA). A rat model of TESLA was examined with a single stretch stimulus applied at the time of tissue expander insertion with evaluation of the aorta at 2, 4 and 7day time points. Measurements as well as histology and proliferation assays were performed and compared to sham controls. The aortic length was increased at all time points without histologic signs of tissue injury. Nuclear density remained unchanged despite the increase in length suggesting cellular hyperplasia. Cellular proliferation was confirmed in endothelial cell layer by Ki-67 stain. Aortic lengthening may be achieved using TESLA. The increase in aortic length can be achieved without tissue injury and results at least partially from cellular hyperplasia. Further studies are required to define the mechanisms involved in the growth of arteries under increased longitudinal stress. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Adapting TESLA technology for future cw light sources using HoBiCaT

    Science.gov (United States)

    Kugeler, O.; Neumann, A.; Anders, W.; Knobloch, J.

    2010-07-01

    The HoBiCaT facility has been set up and operated at the Helmholtz-Zentrum-Berlin and BESSY since 2005. Its purpose is testing superconducting cavities in cw mode of operation and it was successfully demonstrated that TESLA pulsed technology can be used for cw mode of operation with only minor changes. Issues that were addressed comprise of elevated dynamic thermal losses in the cavity walls, necessary modifications in the cryogenics and the cavity processing, the optimum choice of operational parameters such as cavity temperature or bandwidth, the characterization of higher order modes in the cavity, and the usability of existing tuners and couplers for cw.

  8. Perforating arteries originating from the posterior communicating artery: a 7.0-Tesla MRI study

    OpenAIRE

    Conijn, Mandy M. A.; Hendrikse, Jeroen; Zwanenburg, Jaco J. M.; Takahara, Taro; Geerlings, Mirjam I.; Mali, Willem P. Th. M.; Luijten, Peter R.

    2009-01-01

    The aim of this study was to investigate the ability of time-of-flight (TOF) magnetic resonance (MR) angiography at 7.0?Tesla to show the perforating branches of the posterior communicating artery (PCoA), and to investigate the presence of such visible perforating branches in relation to the size of the feeding PCoA. The secondary aim was to visualise and describe the anterior choroidal artery and the perforating branches of the P1-segment of posterior cerebral artery (P1). Forty-six healthy ...

  9. Performance testing of Tesla NNG 601 activity meter in nuclear medicine department

    International Nuclear Information System (INIS)

    Husak, V.; Kleinbauer, K.

    1980-01-01

    The results are presented of testing activity meter Tesla NNG 601 the production of which began in Czechoslovakia in 1978. The meter is provided with a shielded well-type ionization chamber, the well 42 mm in diameter and 140 mm deep. The parameters of the instrument linearity, volume dependence, accuracy and stability, correctness of calibration were compared with those of other instruments (Searle Analytic, Picker and Capinted). The volume dependence of the Czechoslovak NNG 601 instrument is higher than that in the other instruments, other parameters are the same of better

  10. Requirements, design and specifications of a multipurpose 7 Tesla NMR-system

    International Nuclear Information System (INIS)

    Mehlkopf, A.F.

    1978-01-01

    The requirements as well as the design and the specifications of a multi-purpose high resolution nuclear magnetic resonance spectrometer with superconducting magnet are described. The spectrometer operates at a magnetic fluxdensity of 7 Tesla and has 5 transmitter channels with 4 different frequencies, which can have values between 20 and 300 MHz. With this spectrometer almost all the current high resolution magnetic resonance techniques can be performed under computer control. It can also operate in the non-computer controlled slow passage mode. (Auth.)

  11. Commissioning of the CMS Experiment and the Cosmic Run at Four Tesla

    CERN Document Server

    Chatrchyan, S; Sirunyan, A M; Adam, W; Arnold, B; Bergauer, H; Bergauer, T; Dragicevic, M; Eichberger, M; Erö, J; Friedl, M; Frühwirth, R; Ghete, V M; Hammer, J; Hänsel, S; Hoch, M; Hörmann, N; Hrubec, J; Jeitler, M; Kasieczka, G; Kastner, K; Krammer, M; Liko, D; Magrans de Abril, I; Mikulec, I; Mittermayr, F; Neuherz, B; Oberegger, M; Padrta, M; Pernicka, M; Rohringer, H; Schmid, S; Schöfbeck, R; Schreiner, T; Stark, R; Steininger, H; Strauss, J; Taurok, A; Teischinger, F; Themel, T; Uhl, D; Wagner, P; Waltenberger, W; Walzel, G; Widl, E; Wulz, C E; Chekhovsky, V; Dvornikov, O; Emeliantchik, I; Litomin, A; Makarenko, V; Marfin, I; Mossolov, V; Shumeiko, N; Solin, A; Stefanovitch, R; Suarez Gonzalez, J; Tikhonov, A; Fedorov, A; Karneyeu, A; Korzhik, M; Panov, V; Zuyeuski, R; Kuchinsky, P; Beaumont, W; Benucci, L; Cardaci, M; De Wolf, E A; Delmeire, E; Druzhkin, D; Hashemi, M; Janssen, X; Maes, T; Mucibello, L; Ochesanu, S; Rougny, R; Selvaggi, M; Van Haevermaet, H; Van Mechelen, P; Van Remortel, N; Adler, V; Beauceron, S; Blyweert, S; D'Hondt, J; De Weirdt, S; Devroede, O; Heyninck, J; Kalogeropoulos, A; Maes, J; Maes, M; Mozer, M U; Tavernier, S; Van Doninck, W; Van Mulders, P; Villella, I; Bouhali, O; Chabert, E C; Charaf, O; Clerbaux, B; De Lentdecker, G; Dero, V; Elgammal, S; Gay, A P R; Hammad, G H; Marage, P E; Rugovac, S; Vander Velde, C; Vanlaer, P; Wickens, J; Grunewald, M; Klein, B; Marinov, A; Ryckbosch, D; Thyssen, F; Tytgat, M; Vanelderen, L; Verwilligen, P; Basegmez, S; Bruno, G; Caudron, J; Delaere, C; Demin, P; Favart, D; Giammanco, A; Grégoire, G; Lemaitre, V; Militaru, O; Ovyn, S; Piotrzkowski, K; Quertenmont, L; Schul, N; Beliy, N; Daubie, E; Alves, G A; Pol, M E; Souza, M H G; Carvalho, W; De Jesus Damiao, D; De Oliveira Martins, C; Fonseca De Souza, S; Mundim, L; Oguri, V; Santoro, A; Silva Do Amaral, S M; Sznajder, A; Fernandez Perez Tomei, T R; Ferreira Dias, M A; Gregores, E M; Novaes, S F; Abadjiev, K; Anguelov, T; Damgov, J; Darmenov, N; Dimitrov, L; Genchev, V; Iaydjiev, P; Piperov, S; Stoykova, S; Sultanov, G; Trayanov, R; Vankov, I; Dimitrov, A; Dyulendarova, M; Kozhuharov, V; Litov, L; Marinova, E; Mateev, M; Pavlov, B; Petkov, P; Toteva, Z; Chen, G M; Chen, H S; Guan, W; Jiang, C H; Liang, D; Liu, B; Meng, X; Tao, J; Wang, J; Wang, Z; Xue, Z; Zhang, Z; Ban, Y; Cai, J; Ge, Y; Guo, S; Hu, Z; Mao, Y; Qian, S J; Teng, H; Zhu, B; Avila, C; Baquero Ruiz, M; Carrillo Montoya, C A; Gomez, A; Gomez Moreno, B; Ocampo Rios, A A; Osorio Oliveros, A F; Reyes Romero, D; Sanabria, J C; Godinovic, N; Lelas, K; Plestina, R; Polic, D; Puljak, I; Antunovic, Z; Dzelalija, M; Brigljevic, V; Duric, S; Kadija, K; Morovic, S; Fereos, R; Galanti, M; Mousa, J; Papadakis, A; Ptochos, F; Razis, P A; Tsiakkouri, D; Zinonos, Z; Hektor, A; Kadastik, M; Kannike, K; Müntel, M; Raidal, M; Rebane, L; Anttila, E; Czellar, S; Härkönen, J; Heikkinen, A; Karimäki, V; Kinnunen, R; Klem, J; Kortelainen, M J; Lampén, T; Lassila-Perini, K; Lehti, S; Lindén, T; Luukka, P; Mäenpää, T; Nysten, J; Tuominen, E; Tuominiemi, J; Ungaro, D; Wendland, L; Banzuzi, K; Korpela, A; Tuuva, T; Nedelec, P; Sillou, D; Besancon, M; Chipaux, R; Dejardin, M; Denegri, D; Descamps, J; Fabbro, B; Faure, J L; Ferri, F; Ganjour, S; Gentit, F X; Givernaud, A; Gras, P; Hamel de Monchenault, G; Jarry, P; Lemaire, M C; Locci, E; Malcles, J; Marionneau, M; Millischer, L; Rander, J; Rosowsky, A; Rousseau, D; Titov, M; Verrecchia, P; Baffioni, S; Bianchini, L; Bluj, M; Busson, P; Charlot, C; Dobrzynski, L; Granier de Cassagnac, R; Haguenauer, M; Miné, P; Paganini, P; Sirois, Y; Thiebaux, C; Zabi, A; Agram, J L; Besson, A; Bloch, D; Bodin, D; Brom, J M; Conte, E; Drouhin, F; Fontaine, J C; Gelé, D; Goerlach, U; Gross, L; Juillot, P; Le Bihan, A C; Patois, Y; Speck, J; Van Hove, P; Baty, C; Bedjidian, M; Blaha, J; Boudoul, G; Brun, H; Chanon, N; Chierici, R; Contardo, D; Depasse, P; Dupasquier, T; El Mamouni, H; Fassi, F; Fay, J; Gascon, S; Ille, B; Kurca, T; Le Grand, T; Lethuillier, M; 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Ryan, M J; Seez, C; Sharp, P; Sidiropoulos, G; Stettler, M; Stoye, M; Takahashi, M; Tapper, A; Timlin, C; Tourneur, S; Vazquez Acosta, M; Virdee, T; Wakefield, S; Wardrope, D; Whyntie, T; Wingham, M; Cole, J E; Goitom, I; Hobson, P R; Khan, A; Kyberd, P; Leslie, D; Munro, C; Reid, I D; Siamitros, C; Taylor, R; Teodorescu, L; Yaselli, I; Bose, T; Carleton, M; Hazen, E; Heering, A H; Heister, A; John, J St; Lawson, P; Lazic, D; Osborne, D; Rohlf, J; Sulak, L; Wu, S; Andrea, J; Avetisyan, A; Bhattacharya, S; Chou, J P; Cutts, D; Esen, S; Kukartsev, G; Landsberg, G; Narain, M; Nguyen, D; Speer, T; Tsang, K V; Breedon, R; Calderon De La Barca Sanchez, M; Case, M; Cebra, D; Chertok, M; Conway, J; Cox, P T; Dolen, J; Erbacher, R; Friis, E; Ko, W; Kopecky, A; Lander, R; Lister, A; Liu, H; Maruyama, S; Miceli, T; Nikolic, M; Pellett, D; Robles, J; Searle, M; Smith, J; Squires, M; Stilley, J; Tripathi, M; Vasquez Sierra, R; Veelken, C; Andreev, V; Arisaka, K; Cline, D; Cousins, R; Erhan, S; Hauser, J; 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Yang, Y; Zhang, L; Zhu, K; Zhu, R Y; Akgun, B; Carroll, R; Ferguson, T; Jang, D W; Jun, S Y; Paulini, M; Russ, J; Terentyev, N; Vogel, H; Vorobiev, I; Cumalat, J P; Dinardo, M E; Drell, B R; Ford, W T; Heyburn, B; Luiggi Lopez, E; Nauenberg, U; Stenson, K; Ulmer, K; Wagner, S R; Zang, S L; Agostino, L; Alexander, J; Blekman, F; Cassel, D; Chatterjee, A; Das, S; Gibbons, L K; Heltsley, B; Hopkins, W; Khukhunaishvili, A; Kreis, B; Kuznetsov, V; Patterson, J R; Puigh, D; Ryd, A; Shi, X; Stroiney, S; Sun, W; Teo, W D; Thom, J; Vaughan, J; Weng, Y; Wittich, P; Beetz, C P; Cirino, G; Sanzeni, C; Winn, D; Abdullin, S; Afaq, M A; Albrow, M; Ananthan, B; Apollinari, G; Atac, M; Badgett, W; Bagby, L; Bakken, J A; Baldin, B; Banerjee, S; Banicz, K; Bauerdick, L A T; Beretvas, A; Berryhill, J; Bhat, P C; Biery, K; Binkley, M; Bloch, I; Borcherding, F; Brett, A M; Burkett, K; Butler, J N; Chetluru, V; Cheung, H W K; Chlebana, F; Churin, I; Cihangir, S; Crawford, M; Dagenhart, W; Demarteau, M; Derylo, G; Dykstra, D; Eartly, D P; Elias, J E; Elvira, V D; Evans, D; Feng, L; Fischler, M; Fisk, I; Foulkes, S; Freeman, J; Gartung, P; Gottschalk, E; Grassi, T; Green, D; Guo, Y; Gutsche, O; Hahn, A; Hanlon, J; Harris, R M; Holzman, B; Howell, J; Hufnagel, D; James, E; Jensen, H; Johnson, M; Jones, C D; Joshi, U; Juska, E; Kaiser, J; Klima, B; Kossiakov, S; Kousouris, K; Kwan, S; Lei, C M; Limon, P; Lopez Perez, J A; Los, S; Lueking, L; Lukhanin, G; Lusin, S; Lykken, J; Maeshima, K; Marraffino, J M; Mason, D; McBride, P; Miao, T; Mishra, K; Moccia, S; Mommsen, R; Mrenna, S; Muhammad, A S; Newman-Holmes, C; Noeding, C; O'Dell, V; Prokofyev, O; Rivera, R; Rivetta, C H; Ronzhin, A; Rossman, P; Ryu, S; Sekhri, V; Sexton-Kennedy, E; Sfiligoi, I; Sharma, S; Shaw, T M; Shpakov, D; Skup, E; Smith, R P; Soha, A; Spalding, W J; Spiegel, L; Suzuki, I; Tan, P; Tanenbaum, W; Tkaczyk, S; Trentadue, R; Uplegger, L; Vaandering, E W; Vidal, R; Whitmore, J; Wicklund, E; Wu, W; Yarba, J; Yumiceva, F; Yun, J C; Acosta, D; Avery, P; Barashko, V; Bourilkov, D; Chen, M; Di Giovanni, G P; Dobur, D; Drozdetskiy, A; Field, R D; Fu, Y; Furic, I K; Gartner, J; Holmes, D; Kim, B; Klimenko, S; Konigsberg, J; Korytov, A; Kotov, K; Kropivnitskaya, A; Kypreos, T; Madorsky, A; Matchev, K; Mitselmakher, G; Pakhotin, Y; Piedra Gomez, J; Prescott, C; Rapsevicius, V; Remington, R; Schmitt, M; Scurlock, B; Wang, D; Yelton, J; Ceron, C; Gaultney, V; Kramer, L; Lebolo, L M; Linn, S; Markowitz, P; Martinez, G; Rodriguez, J L; Adams, T; Askew, A; Baer, H; Bertoldi, M; Chen, J; Dharmaratna, W G D; Gleyzer, S V; Haas, J; Hagopian, S; Hagopian, V; Jenkins, M; Johnson, K F; Prettner, E; Prosper, H; Sekmen, S; Baarmand, M M; Guragain, S; Hohlmann, M; Kalakhety, H; Mermerkaya, H; Ralich, R; Vodopiyanov, I; Abelev, B; Adams, M R; Anghel, I M; Apanasevich, L; Bazterra, V E; Betts, R R; Callner, J; Castro, M A; Cavanaugh, R; Dragoiu, C; Garcia-Solis, E J; Gerber, C E; Hofman, D J; Khalatian, S; Mironov, C; Shabalina, E; Smoron, A; Varelas, N; Akgun, U; Albayrak, E A; Ayan, A S; Bilki, B; Briggs, R; Cankocak, K; Chung, K; Clarida, W; Debbins, P; Duru, F; Ingram, F D; Lae, C K; McCliment, E; Merlo, J P; Mestvirishvili, A; Miller, M J; Moeller, A; Nachtman, J; Newsom, C R; Norbeck, E; Olson, J; Onel, Y; Ozok, F; Parsons, J; Schmidt, I; Sen, S; Wetzel, J; Yetkin, T; Yi, K; Barnett, B A; Blumenfeld, B; Bonato, A; Chien, C Y; Fehling, D; Giurgiu, G; Gritsan, A V; Guo, Z J; Maksimovic, P; Rappoccio, S; Swartz, M; Tran, N V; Zhang, Y; Baringer, P; Bean, A; Grachov, O; Murray, M; Radicci, V; Sanders, S; Wood, J S; Zhukova, V; Bandurin, D; Bolton, T; Kaadze, K; Liu, A; Maravin, Y; Onoprienko, D; Svintradze, I; Wan, Z; Gronberg, J; Hollar, J; Lange, D; Wright, D; Baden, D; Bard, R; Boutemeur, M; Eno, S C; Ferencek, D; Hadley, N J; Kellogg, R G; Kirn, M; Kunori, S; Rossato, K; Rumerio, P; Santanastasio, F; Skuja, A; Temple, J; Tonjes, M B; Tonwar, S C; Toole, T; Twedt, E; Alver, B; Bauer, G; Bendavid, J; Busza, W; Butz, E; Cali, I A; Chan, M; D'Enterria, D; Everaerts, P; Gomez Ceballos, G; Hahn, K A; Harris, P; Jaditz, S; Kim, Y; Klute, M; Lee, Y J; Li, W; Loizides, C; Ma, T; Miller, M; Nahn, S; Paus, C; Roland, C; Roland, G; Rudolph, M; Stephans, G; Sumorok, K; Sung, K; Vaurynovich, S; Wenger, E A; Wyslouch, B; Xie, S; Yilmaz, Y; Yoon, A S; Bailleux, D; Cooper, S I; Cushman, P; Dahmes, B; De Benedetti, A; Dolgopolov, A; Dudero, P R; Egeland, R; Franzoni, G; Haupt, J; Inyakin, A; Klapoetke, K; Kubota, Y; Mans, J; Mirman, N; Petyt, D; Rekovic, V; Rusack, R; Schroeder, M; Singovsky, A; Zhang, J; Cremaldi, L M; Godang, R; Kroeger, R; Perera, L; Rahmat, R; Sanders, D A; Sonnek, P; Summers, D; Bloom, K; Bockelman, B; Bose, S; Butt, J; Claes, D R; Dominguez, A; Eads, M; Keller, J; Kelly, T; Kravchenko, I; Lazo-Flores, J; Lundstedt, C; Malbouisson, H; Malik, S; Snow, G R; Baur, U; Iashvili, I; Kharchilava, A; Kumar, A; Smith, K; Strang, M; Alverson, G; Barberis, E; Boeriu, O; Eulisse, G; Govi, G; McCauley, T; Musienko, Y; Muzaffar, S; Osborne, I; Paul, T; Reucroft, S; Swain, J; Taylor, L; Tuura, L; Anastassov, A; Gobbi, B; Kubik, A; Ofierzynski, R A; Pozdnyakov, A; Schmitt, M; Stoynev, S; Velasco, M; Won, S; Antonelli, L; Berry, D; Hildreth, M; Jessop, C; Karmgard, D J; Kolberg, T; Lannon, K; Lynch, S; Marinelli, N; Morse, D M; Ruchti, R; Slaunwhite, J; Warchol, J; Wayne, M; Bylsma, B; Durkin, L S; Gilmore, J; Gu, J; Killewald, P; Ling, T Y; Williams, G; Adam, N; Berry, E; Elmer, P; Garmash, A; Gerbaudo, D; Halyo, V; Hunt, A; Jones, J; Laird, E; Marlow, D; Medvedeva, T; Mooney, M; Olsen, J; Piroué, P; Stickland, D; Tully, C; Werner, J S; Wildish, T; Xie, Z; Zuranski, A; Acosta, J G; Bonnett Del Alamo, M; Huang, X T; Lopez, A; Mendez, H; Oliveros, S; Ramirez Vargas, J E; Santacruz, N; Zatzerklyany, A; Alagoz, E; Antillon, E; Barnes, V E; Bolla, G; Bortoletto, D; Everett, A; Garfinkel, A F; Gecse, Z; Gutay, L; Ippolito, N; Jones, M; Koybasi, O; Laasanen, A T; Leonardo, N; Liu, C; Maroussov, V; Merkel, P; Miller, D H; Neumeister, N; Sedov, A; Shipsey, I; Yoo, H D; Zheng, Y; Jindal, P; Parashar, N; Cuplov, V; Ecklund, K M; Geurts, F J M; Liu, J H; Maronde, D; Matveev, M; Padley, B P; Redjimi, R; Roberts, J; Sabbatini, L; Tumanov, A; Betchart, B; Bodek, A; Budd, H; Chung, Y S; de Barbaro, P; Demina, R; Flacher, H; Gotra, Y; Harel, A; Korjenevski, S; Miner, D C; Orbaker, D; Petrillo, G; Vishnevskiy, D; Zielinski, M; Bhatti, A; Demortier, L; Goulianos, K; Hatakeyama, K; Lungu, G; Mesropian, C; Yan, M; Atramentov, O; Bartz, E; Gershtein, Y; Halkiadakis, E; Hits, D; Lath, A; Rose, K; Schnetzer, S; Somalwar, S; Stone, R; Thomas, S; Watts, T L; Cerizza, G; Hollingsworth, M; Spanier, S; Yang, Z C; York, A; Asaadi, J; Aurisano, A; Eusebi, R; Golyash, A; Gurrola, A; Kamon, T; Nguyen, C N; Pivarski, J; Safonov, A; Sengupta, S; Toback, D; Weinberger, M; Akchurin, N; Berntzon, L; Gumus, K; Jeong, C; Kim, H; Lee, S W; Popescu, S; Roh, Y; Sill, A; Volobouev, I; Washington, E; Wigmans, R; Yazgan, E; Engh, D; Florez, C; Johns, W; Pathak, S; Sheldon, P; Andelin, D; Arenton, M W; Balazs, M; Boutle, S; Buehler, M; Conetti, S; Cox, B; Hirosky, R; Ledovskoy, A; Neu, C; Phillips II, D; Ronquest, M; Yohay, R; Gollapinni, S; Gunthoti, K; Harr, R; Karchin, P E; Mattson, M; Sakharov, A; Anderson, M; Bachtis, M; Bellinger, J N; Carlsmith, D; Crotty, I; Dasu, S; Dutta, S; Efron, J; Feyzi, F; Flood, K; Gray, L; Grogg, K S; Grothe, M; Hall-Wilton, R; Jaworski, M; Klabbers, P; Klukas, J; Lanaro, A; Lazaridis, C; Leonard, J; Loveless, R; Magrans de Abril, M; Mohapatra, A; Ott, G; Polese, G; Reeder, D; Savin, A; Smith, W H; Sourkov, A; Swanson, J; Weinberg, M; Wenman, D; Wensveen, M; White, A

    2010-01-01

    The CMS Collaboration conducted a month-long data-taking exercise known as the Cosmic Run At Four Tesla in late 2008 in order to complete the commissioning of the experiment for extended operation. The operational lessons resulting from this exercise were addressed in the subsequent shutdown to better prepare CMS for LHC beams in 2009. The cosmic data collected have been invaluable to study the performance of the detectors, to commission the alignment and calibration techniques, and to make several cosmic ray measurements. The experimental setup, conditions, and principal achievements from this data-taking exercise are described along with a review of the preceding integration activities.

  12. Measurement and adjustment of dumb-bells for 9-cell TESLA cavity

    International Nuclear Information System (INIS)

    Xu Wencan; Quan Shengwen; Hao Jiankui; Jiang Tao; Zhang Baocheng; Zhao Kui

    2008-01-01

    Correct Dumb-bells are very important to make sure the right field flatness, frequency of TM010 mode and length of 9-cell TESLA cavity. The shape of the dumb-bells will be wrong due to deep drawing, machining and EB welding. Then, the dumb-bells should be adjusted after iris and stiffness welding according to the mechanical and microwave measurement. Peking University has set up facilities for measuring and correcting the dumb-bells. This paper discusses the method of measuring and correcting the dumb-bells. (authors)

  13. Axonal diameter and density estimated with 7-Tesla hybrid diffusion imaging in transgenic Alzheimer rats

    OpenAIRE

    Daianu, Madelaine; Jacobs, Russell E.; Town, Terrence; Thompson, Paul M.

    2016-01-01

    Diffusion-weighted MR imaging (DWI) is a powerful tool to study brain tissue microstructure. DWI is sensitive to subtle changes in the white matter (WM), and can provide insight into abnormal brain changes in diseases such as Alzheimer’s disease (AD). In this study, we used 7-Tesla hybrid diffusion imaging (HYDI) to scan 3 transgenic rats (line TgF344-AD; that model the full clinico-pathological spectrum of the human disease) ex vivo at 10, 15 and 24 months. We acquired 300 DWI volumes across...

  14. Design of a 6 Tesla wiggler for the National Synchrotron Light Source

    International Nuclear Information System (INIS)

    Hsieh, H.; Krinsky, S.; Luccio, A.; van Steenbergen, A.

    1981-01-01

    A 6-pole, 6 Tesla wiggler with Nb-Ti superconducting windings has been designed, to be installed in a straight section of the 2.5 GeV x-ray storage ring of the NSLS. The technical problems of this magnet are discussed, in particular the optimization of the two-layer magnetic windings and the mechanical structure designed to counteract the strong magnetic forces. The effects of the insertion of the wiggler in the storage ring lattice are also studied

  15. Commissioning of the CMS experiment and the cosmic run at four tesla

    International Nuclear Information System (INIS)

    2010-01-01

    The CMS Collaboration conducted a month-long data-taking exercise known as the Cosmic Run At Four Tesla in late 2008 in order to complete the commissioning of the experiment for extended operation. The operational lessons resulting from this exercise were addressed in the subsequent shutdown to better prepare CMS for LHC beams in 2009. The cosmic data collected have been invaluable to study the performance of the detectors, to commission the alignment and calibration techniques, and to make several cosmic ray measurements. The experimental setup, conditions, and principal achievements from this data-taking exercise are described along with a review of the preceding integration activities.

  16. NORM in the vicinity of the thermal power plant 'Nikola Tesla' B - experimental results

    International Nuclear Information System (INIS)

    Kisic, D.; Veselinovic, N.; Tokonami, S.; Celikovic, I.; Stojanovic, Z.; Cuknic, O.; Nemcevic, M.; Simovic, R.; Zunic, Z. S.

    2009-01-01

    The paper deals with the results related to identification of ionizing radiation from natural sources (NORM - Naturally Occurring Radioactive Materials) in the vicinity of the fly ash deposit of Thermal Power Plant 'Nikola Tesla B' (TENT B). The survey included such as follows: determination of distribution of naturally soil occurring gases radon ( 222 Rn) and thoron ( 220 Tn) in the vicinity of TENT B by means of passive discriminative solid state nuclear track detectors (CR 39) at the depth of 80 cm with defining its appropriate GPS coordinates. (author) [sr

  17. Large scale Tesla coil guided discharges initiated by femtosecond laser filamentation in air

    Science.gov (United States)

    Arantchouk, L.; Point, G.; Brelet, Y.; Prade, B.; Carbonnel, J.; André, Y.-B.; Mysyrowicz, A.; Houard, A.

    2014-07-01

    The guiding of meter scale electric discharges produced in air by a Tesla coil is realized in laboratory using a focused terawatt laser pulse undergoing filamentation. The influence of the focus position, the laser arrival time, or the gap length is studied to determine the best conditions for efficient laser guiding. Discharge parameters such as delay, jitter, and resistance are characterized. An increase of the discharge length by a factor 5 has been achieved with the laser filaments, corresponding to a mean breakdown field of 2 kV/cm for a 1.8 m gap length. Consecutive guided discharges at a repetition rate of 10 Hz are also reported.

  18. Design of the 1.8 Tesla wiggler for the DAΦNE Main Rings

    International Nuclear Information System (INIS)

    Sanelli, C.; Hsieh, H.

    1992-01-01

    The electromagnetic and mechanical design of the eight wiggler magnets for DAΦNE Main Rings is described. The wigglers have a large 1.8 Tesla flat top magnetic field, 64 cm period and 4 cm gap. The magnetic 3-D calculations, the electromagnetic design and the adopted mechanical solutions, with particular attention to the vacuum chamber problems are described. A full scale prototype (5 full poles and two half pole) will be constructed in order to verify the accuracy of magnetic calculations, the end pole design and the multipole content. (author) 4 figs.; 1 tab

  19. 3.0 Tesla magnetic resonance imaging: A new standard in liver imaging?

    Science.gov (United States)

    Girometti, Rossano

    2015-01-01

    An ever-increasing number of 3.0 Tesla (T) magnets are installed worldwide. Moving from the standard of 1.5 T to higher field strength implies a number of potential advantage and drawbacks, requiring careful optimization of imaging protocols or implementation of novel hardware components. Clinical practice and literature review suggest that state-of-the-art 3.0 T is equivalent to 1.5 T in the assessment of focal liver lesions and diffuse liver disease. Therefore, further technical improvements are needed in order to fully exploit the potential of higher field strength. PMID:26244063

  20. TESLA cavity modeling and digital implementation in FPGA technology for control system development

    International Nuclear Information System (INIS)

    Czarski, T.; Pozniak, K.T.; Romaniuk, R.S.; Simrock, S.

    2006-01-01

    The electromechanical model of the TESLA cavity has been implemented in FPGA technology for real-time testing of the control system. The model includes Lorentz force detuning and beam loading effects. Step operation and vector stimulus operation modes are applied for the evaluation of a FPGA cavity simulator operated by a digital controller. The performance of the cavity hardware model is verified by comparing with a software model of the cavity implemented in the MATLAB system. The numerical aspects are considered for an optimal DSP calculation. Some experimental results are presented for different cavity operational conditions. (orig.)

  1. Electropolishing on single-cell: (TESLA, Reentrant and Low Loss shapes) Comsol modelling

    International Nuclear Information System (INIS)

    Bruchon, M.

    2007-01-01

    In the framework of improvement of cavity electropolishing, modelling permits to evaluate some parameters not easily accessible by experiments and can also help us to guide them. Different laboratories (DESY, Fermilab) work on electro or chemical polishing modelling with different approaches and softwares. At CEA Saclay, COMSOL software is used to model horizontal electropolishing of cavity in two dimensions. The goal of this study has been motivated by improvement of our electropolishing setup by modifying the arrival of the acid. The influence of a protuberant cathode has been evaluated and compared for different shapes of single cell cavities: TESLA, ILC Low Loss (LL ILC ), and ILC Reentrant (RE ILC ). (author)

  2. Tesla : an application for real-time data analysis in High Energy Physics

    CERN Document Server

    Aaij, R.

    Upgrades to the LHCb computing infrastructure in the first long shutdown of the LHC have allowed for high quality decay information to be calculated by the software trigger making a separate offline event reconstruction unnecessary. Furthermore, the storage space of the triggered candidate is an order of magnitude smaller than the entire raw event that would otherwise need to be persisted. Tesla, following the LHCb renowned physicist naming convention, is an application designed to process the information calculated by the trigger, with the resulting output used to directly perform physics measurements.

  3. 3.0 Tesla magnetic resonance imaging: A new standard in liver imaging?

    Science.gov (United States)

    Girometti, Rossano

    2015-07-28

    An ever-increasing number of 3.0 Tesla (T) magnets are installed worldwide. Moving from the standard of 1.5 T to higher field strength implies a number of potential advantage and drawbacks, requiring careful optimization of imaging protocols or implementation of novel hardware components. Clinical practice and literature review suggest that state-of-the-art 3.0 T is equivalent to 1.5 T in the assessment of focal liver lesions and diffuse liver disease. Therefore, further technical improvements are needed in order to fully exploit the potential of higher field strength.

  4. Progress in the study and construction of the TESLA test facility injector

    Energy Technology Data Exchange (ETDEWEB)

    Chehab, R.; Bernard, M.; Bourdon, J.C.; Garvey, T. [Paris-11 Univ., 91 - Orsay (France). Lab. de l`Accelerateur Lineaire; Aune, B.; Desmons, M.; Fusellier, J.; Gougnaud, F. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee; Buhler, S.; Junquera, T. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire] [and others

    1995-12-31

    A 500 MeV, 1.3 GHz superconducting linear accelerator is being studied and built to serve as a test facility for the TESLA linear collider project. The phase 1 injector consists of a 250 keV electron gun, buncher and a superconducting capture cavity at the main linac frequency. The main characteristics (intensity, position, emittance, bunch length, energy spread) are to be measured using different techniques. A particular effort will be made on the use of optical transition radiation (OTR) for the determination of the transverse beam emittance as well as the bunch length. (K.A.). 7 refs.

  5. Progress in the study and construction of the TESLA test facility injector

    International Nuclear Information System (INIS)

    Chehab, R.; Bernard, M.; Bourdon, J.C.; Garvey, T.; Aune, B.; Desmons, M.; Fusellier, J.; Gougnaud, F.; Buhler, S.; Junquera, T.

    1995-01-01

    A 500 MeV, 1.3 GHz superconducting linear accelerator is being studied and built to serve as a test facility for the TESLA linear collider project. The phase 1 injector consists of a 250 keV electron gun, buncher and a superconducting capture cavity at the main linac frequency. The main characteristics (intensity, position, emittance, bunch length, energy spread) are to be measured using different techniques. A particular effort will be made on the use of optical transition radiation (OTR) for the determination of the transverse beam emittance as well as the bunch length. (K.A.)

  6. Intraindividual comparison of image quality in MR urography at 1.5 and 3 Tesla in an animal model

    Energy Technology Data Exchange (ETDEWEB)

    Regier, M.; Adam, G.; Kemper, J. [Klinik und Poliklinik fuer Diagnostische und Interventionelle Radiologie, Universitaetsklinikum Hamburg-Eppendorf (Germany); Nolte-Ernsting, C. [Klinik fuer Diagnostische und Interventionelle Radiologie, Universitaetsklinikum Hamburg-Eppendorf (Germany)

    2008-10-15

    Purpose: experimental evaluation of image quality of the upper urinary tract in MR urography (MRU) at 1.5 and 3 Tesla in a porcine model. Materials and methods: in this study four healthy domestic pigs, weighing between 71 and 80 kg (mean 73.6 kg), were examined with a standard T 1w 3D-GRE and a high-resolution (HR) T 1w 3D-GRE sequence at 1.5 and 3 Tesla. Additionally, at 3 Tesla both sequences were performed with parallel imaging (SENSE factor 2). The MR urographic scans were performed after intravenous injection of gadolinium-DTPA (0.1 mmol/kg body weight (bw)) and low-dose furosemide (0.1 mg/kg bw). Image evaluation was performed by two independent radiologists blinded to sequence parameters and field strength. Image analysis included grading of image quality of the segmented collecting system based on a five-point grading scale regarding anatomical depiction and artifacts observed (1: the majority of the segment (> 50%) was not depicted or was obscured by major artifacts; 5: the segment was visualized without artifacts and had sharply defined borders). Signal-to-noise (SNR) and contrast-to-noise (CNR) ratios were determined. Statistical analysis included {kappa}-statistics, Wilcoxon and paired student t-test. Results: the mean scores for MR urographies at 1.5 Tesla were 2.83 for the 3D-GRE and 3.48 for the HR 3D-GRE sequence. Significantly higher values were determined using the corresponding sequences at 3 Tesla, averaging 3.19 for the 3D-GRE (p = 0.047) and 3.92 for the HR 3D-GRE (p = 0.023) sequence. Delineation of the pelvicaliceal system was rated significantly higher at 3 Tesla compared to 1.5 Tesla (3D-GRE: p = 0.015; HR 3D-GRE: p = 0.006). At 3 Tesla the mean SNR and CNR were significantly higher (p < 0.05). A {kappa} of 0.67 indicated good interobserver agreement. (orig.)

  7. Intraindividual comparison of image quality in MR urography at 1.5 and 3 Tesla in an animal model

    International Nuclear Information System (INIS)

    Regier, M.; Adam, G.; Kemper, J.; Nolte-Ernsting, C.

    2008-01-01

    Purpose: experimental evaluation of image quality of the upper urinary tract in MR urography (MRU) at 1.5 and 3 Tesla in a porcine model. Materials and methods: in this study four healthy domestic pigs, weighing between 71 and 80 kg (mean 73.6 kg), were examined with a standard T 1w 3D-GRE and a high-resolution (HR) T 1w 3D-GRE sequence at 1.5 and 3 Tesla. Additionally, at 3 Tesla both sequences were performed with parallel imaging (SENSE factor 2). The MR urographic scans were performed after intravenous injection of gadolinium-DTPA (0.1 mmol/kg body weight (bw)) and low-dose furosemide (0.1 mg/kg bw). Image evaluation was performed by two independent radiologists blinded to sequence parameters and field strength. Image analysis included grading of image quality of the segmented collecting system based on a five-point grading scale regarding anatomical depiction and artifacts observed (1: the majority of the segment (> 50%) was not depicted or was obscured by major artifacts; 5: the segment was visualized without artifacts and had sharply defined borders). Signal-to-noise (SNR) and contrast-to-noise (CNR) ratios were determined. Statistical analysis included κ-statistics, Wilcoxon and paired student t-test. Results: the mean scores for MR urographies at 1.5 Tesla were 2.83 for the 3D-GRE and 3.48 for the HR 3D-GRE sequence. Significantly higher values were determined using the corresponding sequences at 3 Tesla, averaging 3.19 for the 3D-GRE (p 0.047) and 3.92 for the HR 3D-GRE (p = 0.023) sequence. Delineation of the pelvicaliceal system was rated significantly higher at 3 Tesla compared to 1.5 Tesla (3D-GRE: p = 0.015; HR 3D-GRE: p = 0.006). At 3 Tesla the mean SNR and CNR were significantly higher (p < 0.05). A κ of 0.67 indicated good interobserver agreement. (orig.)

  8. Measuring the performance of the coaxial HOM coupler on a 2-cell TESLA-shape copper cavity

    International Nuclear Information System (INIS)

    Wang Fang; Wang Erdong; Zhang Baocheng; Zhao Kui

    2009-01-01

    Coaxial High Order Mode (HOM) couplers have been fabricated at Peking University and their RF performance has been measured on a test device consisting of a coaxial transmission line and a 2-cell TESLA-shape copper cavity. The test results on the 2-cell TESLA-shape copper cavity with HOM couplers indicate that the coupler can cut off the fundamental mode TM 010 and absorb HOMs effectively after a careful adjustment. The optimal angle of the HOM coupler with the beam tube is found. The initial test results of HOM couplers are presented in this paper. (authors)

  9. MALDI Mass Spectral Imaging of Bile Acids Observed as Deprotonated Molecules and Proton-Bound Dimers from Mouse Liver Sections

    Science.gov (United States)

    Rzagalinski, Ignacy; Hainz, Nadine; Meier, Carola; Tschernig, Thomas; Volmer, Dietrich A.

    2018-02-01

    Bile acids (BAs) play two vital roles in living organisms, as they are involved in (1) the secretion of cholesterol from liver, and (2) the lipid digestion/absorption in the intestine. Abnormal bile acid synthesis or secretion can lead to severe liver disorders. Even though there is extensive literature on the mass spectrometric determination of BAs in biofluids and tissue homogenates, there are no reports on the spatial distribution in the biliary network of the liver. Here, we demonstrate the application of high mass resolution/mass accuracy matrix-assisted laser desorption/ionization (MALDI)-Fourier-transform ion cyclotron resonance (FTICR) to MS imaging (MSI) of BAs at high spatial resolutions (pixel size, 25 μm). The results show chemical heterogeneity of the mouse liver sections with a number of branching biliary and blood ducts. In addition to ion signals from deprotonation of the BA molecules, MALDI-MSI generated several further intense signals at larger m/z for the BAs. These signals were spatially co-localized with the deprotonated molecules and easily misinterpreted as additional products of BA biotransformations. In-depth analysis of accurate mass shifts and additional electrospray ionization and MALDI-FTICR experiments, however, confirmed them as proton-bound dimers. Interestingly, dimers of bile acids, but also unusual mixed dimers of different taurine-conjugated bile acids and free taurine, were identified. Since formation of these complexes will negatively influence signal intensities of the desired [M - H]- ions and significantly complicate mass spectral interpretations, two simple broadband techniques were proposed for non-selective dissociation of dimers that lead to increased signals for the deprotonated BAs. [Figure not available: see fulltext.

  10. Chemical exchange saturation transfer MR imaging of Parkinson's disease at 3 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Li, Chunmei; Peng, Shuai; Wang, Rui; Chen, Min [Beijing Hospital, Department of Radiology, Beijing (China); Chen, Haibo; Su, Wen [Beijing Hospital, Department of Neurology, Beijing (China); Zhao, Xuna [Peking University, Center for MRI Research and Beijing City Key Lab for Medical Physics and Engineering, Beijing (China); Zhou, Jinyuan [Johns Hopkins University, Department of Radiology, Baltimore, MD (United States)

    2014-10-15

    To demonstrate the feasibility of using chemical exchange saturation transfer (CEST) imaging to detect Parkinson's disease (PD) in patients at 3 Tesla. Twenty-seven PD patients (17 men and 10 women; age range, 54-77 years) and 22 age-matched normal controls (13 men and 9 women; age range, 55-73 years) were examined on a 3-Tesla MRI system. Magnetization transfer spectra with 31 different frequency offsets (-6 to 6 ppm) were acquired at two transverse slices of the head, including the basal ganglia and midbrain. One-way analysis of variance tests was used to compare the differences in CEST imaging signals between PD patients and normal controls. Total CEST signal between the offsets of 0 and 4 ppm in the substantia nigra was significantly lower in PD patients than in normal controls (P = 0.006), which could be associated with the loss of dopaminergic neurons. Protein-based CEST imaging signals at the offset of 3.5 ppm in the globus pallidus, putamen and caudate were significantly increased in PD patients, compared to normal controls (P < 0.001, P = 0.003, P < 0.001, respectively). CEST imaging signals could potentially serve as imaging biomarkers to aid in the non-invasive molecular diagnosis of PD. (orig.)

  11. 3D calculations of the Superconducting Super Collider (SSC) 3 Tesla magnet

    International Nuclear Information System (INIS)

    Lari, R.J.

    1984-01-01

    A 20 TeV Superconducting Super Collider (SSC) proton accelerator is being proposed by the High Energy Physics Community. One proposal would consist of a ring of magnets 164 km in circumference with a field strength of 3 Tesla and would cost 2.7 billion dollars. The magnet consists of stacked steel laminations with superconducting coils. The desired field uniformity is obtained for all fields from 0.2 to 3 Tesla by using three (or more) different pole shapes. These three different laminations are stacked in the order 1-2-3-1-2-3-... creating a truly three dimensional geometry. A three laminated stack 1-2-3 with periodic boundary conditions at 1 and 3 was assigned about 5000 finite elements per lamination and solved using the computer program TOSCA. To check the TOSCA results, the field of each of the three different shaped laminations was calculated separately using periodic boundary conditions and compared to the two dimensional field calculations using TRIM. This was done for a constant permeability of 2000 and using the B-H table for fully annealed 1010 steel. The difference of the field calculations in the region of interest was always less than +-.2%

  12. Intraoperative 3-tesla MRI in the management of paediatric cranial tumours - initial experience

    International Nuclear Information System (INIS)

    Avula, Shivaram; Garlick, Deborah; Abernethy, Laurence J.; Mallucci, Connor L.; Pizer, Barry; Crooks, Daniel

    2012-01-01

    Intraoperative MRI (ioMRI) has been gaining recognition because of its value in the neurosurgical management of cranial tumours. There is limited documentation of its value in children. To review the initial experience of a paediatric 3-Tesla ioMRI unit in the management of cranial tumours. Thirty-eight children underwent ioMRI during 40 cranial tumour resections using a 3-Tesla MR scanner co-located with the neurosurgical operating theatre. IoMRI was performed to assess the extent of tumour resection and/or to update neuronavigation. The intraoperative and follow-up scans, and the clinical records were reviewed. In 27/40 operations, complete resection was intended. IoMRI confirmed complete resection in 15/27 (56%). As a consequence, surgical resection was extended in 5/27 (19%). In 6/27 (22%), ioMRI was equivocal for residual tumour. In 13/40 (33%) operations, the surgical aim was to partially resect the tumour. In 7 of the 13 (54%), surgical resection was extended following ioMRI. In our initial experience, ioMRI has increased the rate of complete resection, with intraoperative surgical strategy being modified in 30% of procedures. Collaborative analysis of ioMRI by the radiologist and neurosurgeon is vital to avoid errors in interpretation. (orig.)

  13. Intraoperative 3-tesla MRI in the management of paediatric cranial tumours - initial experience

    Energy Technology Data Exchange (ETDEWEB)

    Avula, Shivaram; Garlick, Deborah; Abernethy, Laurence J. [Alder Hey Children' s NHS Foundation Trust, Department of Radiology, Liverpool (United Kingdom); Mallucci, Connor L. [Alder Hey Children' s Hospital, Department of Neurosurgery, Liverpool (United Kingdom); Pizer, Barry [Alder Hey Children' s Hospital, Department of Oncology, Liverpool (United Kingdom); Crooks, Daniel [Walton Centre for Neurology and Neurosurgery, Department of Pathology, Liverpool (United Kingdom)

    2012-02-15

    Intraoperative MRI (ioMRI) has been gaining recognition because of its value in the neurosurgical management of cranial tumours. There is limited documentation of its value in children. To review the initial experience of a paediatric 3-Tesla ioMRI unit in the management of cranial tumours. Thirty-eight children underwent ioMRI during 40 cranial tumour resections using a 3-Tesla MR scanner co-located with the neurosurgical operating theatre. IoMRI was performed to assess the extent of tumour resection and/or to update neuronavigation. The intraoperative and follow-up scans, and the clinical records were reviewed. In 27/40 operations, complete resection was intended. IoMRI confirmed complete resection in 15/27 (56%). As a consequence, surgical resection was extended in 5/27 (19%). In 6/27 (22%), ioMRI was equivocal for residual tumour. In 13/40 (33%) operations, the surgical aim was to partially resect the tumour. In 7 of the 13 (54%), surgical resection was extended following ioMRI. In our initial experience, ioMRI has increased the rate of complete resection, with intraoperative surgical strategy being modified in 30% of procedures. Collaborative analysis of ioMRI by the radiologist and neurosurgeon is vital to avoid errors in interpretation. (orig.)

  14. Cryomodule tests of the TESLA-like superconducting cavity in KEK-STF

    International Nuclear Information System (INIS)

    Kako, Eiji; Sato, Masato; Shishido, Toshio; Noguchi, Shuichi; Hatori, Hirofumi; Hayano, Hitoshi; Yamamoto, Yasuchika; Watanabe, Ken

    2008-01-01

    Construction of STF (Superconducting RF Test Facility) is being carried out at KEK. The STF-Baseline superconducting cavity system, which includes four TESLA-like 9-cell cavities, input couplers and frequency tuners, has been developed for the future ILC project. A 6-m cryomodule including one of four TESLA-like cavities was assembled, and the cryomodule was installed in the tunnel for the initial test, called the STF Phase-0.5. The first cool-down of the cryomodule and high power tests of the cavity had been carried out at 2 K from October to November, 2007. The maximum accelerating gradient (Eacc, max) of 19.3 MV/m was achieved in a specific pulse width of 1.5 msec and a repetition rate of 5 Hz, (23.4 MV/m in a shorter pulse width of 0.6 msec). Compensation of Lorentz force detuning at 18 MV/m was successfully demonstrated by using a piezo tuner. The second cryomodule test for four cavities, called the STF Phase-1.0, is scheduled in July, 2008. (author)

  15. Conventional 20-TeV, 10-Tesla, p/sup +-/ colliders

    International Nuclear Information System (INIS)

    Diebold, R.; Ankenbrandt, C.; Collins, T.

    1982-01-01

    The performance of various 20-TeV colliders is discussed assuming 10-Tesla bending magnets. For bunched beams, the luminosity for anti pp collisions will be approximately x 10 31 cm - 2 sec - 1 where is the average number of interactions per bunch collision desired by the experimenters; for pp collisions this becomes x 10 32 cm - 2 sec - 1 . Values of up to 25 can be accommodated in a straightforward manner. Continuous beam pp collisions may yield a luminosity of 10 33 to 10 34 cm - 2 sec - 1 if the large amount of energy in the intense beams can be handled. Assuming that adequate and reliable 10-Tesla magnets can be built without unforeseen difficulties, the construction cost of such a collider, together with its new laboratory in the desert, would cost 2 to 3 billion dollars (FY-82 dollars) using present-day, conventional techniques. Although such a machine appears straightforward to build, considerable R and D will be required in order to optimize the design and bring down costs

  16. Cryogenic Current Comparator for Absolute Measurement of the Dark Current of the Superconducting Cavities for Tesla

    CERN Document Server

    Knaack, K; Wittenburg, K

    2003-01-01

    A newly high performance SQUID based measurement system for detecting dark currents, generated by superconducting cavities for TESLA is proposed. It makes use of the Cryogenic Current Comparator principle and senses dark currents in the nA range with a small signal bandwidth of 70 kHz. To reach the maximum possible energy in the TESLA project is a strong motivation to push the gradients of the superconducting cavities closer to the physical limit of 50 MV/m. The field emission of electrons (the so called dark current) of the superconducting cavities at strong fields may limit the maximum gradient. The absolute measurement of the dark current in correlation with the gradient will give a proper value to compare and classify the cavities. This contribution describes a Cryogenic Current Comparator (CCC) as an excellent and useful tool for this purpose. The most important component of the CCC is a high performance DC SQUID system which is able to measure extremely low magnetic fields, e.g. caused by the extracted ...

  17. Chemical exchange saturation transfer MR imaging of Parkinson's disease at 3 Tesla

    International Nuclear Information System (INIS)

    Li, Chunmei; Peng, Shuai; Wang, Rui; Chen, Min; Chen, Haibo; Su, Wen; Zhao, Xuna; Zhou, Jinyuan

    2014-01-01

    To demonstrate the feasibility of using chemical exchange saturation transfer (CEST) imaging to detect Parkinson's disease (PD) in patients at 3 Tesla. Twenty-seven PD patients (17 men and 10 women; age range, 54-77 years) and 22 age-matched normal controls (13 men and 9 women; age range, 55-73 years) were examined on a 3-Tesla MRI system. Magnetization transfer spectra with 31 different frequency offsets (-6 to 6 ppm) were acquired at two transverse slices of the head, including the basal ganglia and midbrain. One-way analysis of variance tests was used to compare the differences in CEST imaging signals between PD patients and normal controls. Total CEST signal between the offsets of 0 and 4 ppm in the substantia nigra was significantly lower in PD patients than in normal controls (P = 0.006), which could be associated with the loss of dopaminergic neurons. Protein-based CEST imaging signals at the offset of 3.5 ppm in the globus pallidus, putamen and caudate were significantly increased in PD patients, compared to normal controls (P < 0.001, P = 0.003, P < 0.001, respectively). CEST imaging signals could potentially serve as imaging biomarkers to aid in the non-invasive molecular diagnosis of PD. (orig.)

  18. Seeing Like a Tesla: How Can We Anticipate Self-Driving Worlds?

    Directory of Open Access Journals (Sweden)

    Jack Stilgoe

    2018-02-01

    Full Text Available In the last five years, investment and innovation in self-driving cars has accelerated dramatically. Automotive autonomy, once seen as impossible, is now sold as inevitable. Much of the governance discussion has centred on risk: will the cars be safer than their human-controlled counterparts? As with conventional cars, harder long-term questions relate to the future worlds that self-driving technologies might enable or even demand. The vision of an autonomous vehicle – able to navigate the world’s complexity using only its sensors and processors – on offer from companies like Tesla is intentionally misleading. So-called “autonomous” vehicles will depend upon webs of social and technical connectivity. For their purported benefits to be realised, infrastructures that were designed around humans will need to be upgraded in order to become machine-readable. It is vital to anticipate the politics of self-driving worlds in order to avoid exacerbating the inequalities that have emerged around conventional cars. Rather than being dazzled by the Tesla view, policymakers should start seeing like a city, from multiple perspectives. Good governance for self-driving cars means democratising experimentation and creating genuine collaboration between companies and local governments.

  19. BOLD cardiovascular magnetic resonance at 3.0 tesla in myocardial ischemia.

    Science.gov (United States)

    Manka, Robert; Paetsch, Ingo; Schnackenburg, Bernhard; Gebker, Rolf; Fleck, Eckart; Jahnke, Cosima

    2010-09-22

    The purpose of this study was to determine the ability of blood oxygen level dependent (BOLD) cardiovascular magnetic resonance (CMR) to detect stress-inducible myocardial ischemic reactions in the presence of angiographically significant coronary artery disease (CAD). Forty-six patients (34 men; age 65 ± 9 years,) with suspected or known coronary artery disease underwent CMR at 3Tesla prior to clinically indicated invasive coronary angiography. BOLD CMR was performed in 3 short axis slices of the heart at rest and during adenosine stress (140 μg/kg/min) followed by late gadolinium enhancement (LGE) imaging. In all 16 standard myocardial segments, T2* values were derived at rest and under adenosine stress. Quantitative coronary angiography served as the standard of reference and defined normal myocardial segments (i.e. all 16 segments in patients without any CAD), ischemic segments (i.e. supplied by a coronary artery with ≥50% luminal narrowing) and non-ischemic segments (i.e. supplied by a non-significantly stenosed coronary artery in patients with significant CAD). Coronary angiography demonstrated significant CAD in 23 patients. BOLD CMR at rest revealed significantly lower T2* values for ischemic segments (26.7 ± 11.6 ms) compared to normal (31.9 ± 11.9 ms; p BOLD CMR at 3Tesla proved feasible and differentiated between ischemic, non-ischemic, and normal myocardial segments in a clinical patient population. BOLD CMR during vasodilator stress identified patients with significant CAD.

  20. Collimation system for the VUV free-electron laser at the TESLA test facility

    International Nuclear Information System (INIS)

    Schlarb, H.

    2001-11-01

    To perform a proof-of-principle experiment for a Free Electron Laser operating at VUV wavelengths an undulator has been installed in the TESLA Test Facility linac phase I. To meet the requirements on the magnetic field quality in the undulator, a hybrid type structure with NdFeB permanent magnets has been chosen. The permanent magnets are sensitive to radiation by high energy particles. In order to perform the various experiments planned at the TESLA Test Facility linac, a collimator section has been installed to protect the undulator from radiation. In this thesis the design, performance and required steps for commissioning the collimator system are presented. To identify potential difficulties for the linac operation, the beam halo and the dark current transport through the entire linac is discussed. Losses of primary electrons caused by technical failures, component misalignments, and operation errors are investigated by tracking simulations, in order to derive a complete understanding of the absorbed dose in the permanent magnets of the undulator. Various topics related to a collimator system such as the removal of secondary particles produced at the collimators, generation and shielding of neutrons, excitation of wake fields, and beam based alignment concepts are important subjects of this thesis. (orig.)

  1. In vivo sensitivity estimation and imaging acceleration with rotating RF coil arrays at 7 Tesla

    Science.gov (United States)

    Li, Mingyan; Jin, Jin; Zuo, Zhentao; Liu, Feng; Trakic, Adnan; Weber, Ewald; Zhuo, Yan; Xue, Rong; Crozier, Stuart

    2015-03-01

    Using a new rotating SENSitivity Encoding (rotating-SENSE) algorithm, we have successfully demonstrated that the rotating radiofrequency coil array (RRFCA) was capable of achieving a significant reduction in scan time and a uniform image reconstruction for a homogeneous phantom at 7 Tesla. However, at 7 Tesla the in vivo sensitivity profiles (B1-) become distinct at various angular positions. Therefore, sensitivity maps at other angular positions cannot be obtained by numerically rotating the acquired ones. In this work, a novel sensitivity estimation method for the RRFCA was developed and validated with human brain imaging. This method employed a library database and registration techniques to estimate coil sensitivity at an arbitrary angular position. The estimated sensitivity maps were then compared to the acquired sensitivity maps. The results indicate that the proposed method is capable of accurately estimating both magnitude and phase of sensitivity at an arbitrary angular position, which enables us to employ the rotating-SENSE algorithm to accelerate acquisition and reconstruct image. Compared to a stationary coil array with the same number of coil elements, the RRFCA was able to reconstruct images with better quality at a high reduction factor. It is hoped that the proposed rotation-dependent sensitivity estimation algorithm and the acceleration ability of the RRFCA will be particularly useful for ultra high field MRI.

  2. Analysis and tests of TF magnet insulation samples for the JET upgrade to 4 tesla

    CERN Document Server

    Miele, P; Bettinali, L; Kaye, A; Last, J; Papastergiou, S; Riccardo, V; Visca, E

    2000-01-01

    The JET Toroidal Field (TF) coils were originally designed for operation at 3.4 tesla. In order to upgrade the field to 4 tesla and thus improve the performance of the JET machine, new mechanical tests and analysis were carried out on the insulation of TF coil samples. They are aimed at investigating the mechanical properties and the status of the insulation in order to set allowable stresses and force limits. In particular since the shear stress in the insulation is strongly affected by the shear modulus of elasticity G, it is important to measure this parameter. A method for the measurement of G in glass-resin fibres, the V-notched beam method (Iosipescu method) , was applied. The particular shape of the rectangular Iosipescu V- notched sample and the particular modality of force application produce pure shear stress for a reliable measurement of the G value and of the shear strength of the insulation. The effect of temperature on these mechanical properties was also investigated. Results show higher averag...

  3. Wakefield and RF Kicks Due to Coupler Asymmetry in TESLA-Type Accelerating Cavities

    International Nuclear Information System (INIS)

    Bane, K

    2008-01-01

    In a future linear collider, such as the International Linear Collider (ILC), trains of high current, low emittance bunches will be accelerated in a linac before colliding at the interaction point. Asymmetries in the accelerating cavities of the linac will generate fields that will kick the beam transversely and degrade the beam emittance and thus the collider performance. In the main linac of the ILC, which is filled with TESLA-type superconducting cavities, it is the fundamental (FM) and higher mode (HM) couplers that are asymmetric and thus the source of such kicks. The kicks are of two types: one, due to (the asymmetry in) the fundamental RF fields and the other, due to transverse wakefields that are generated by the beam even when it is on axis. In this report we calculate the strength of these kicks and estimate their effect on the ILC beam. The TESLA cavity comprises nine cells, one HM coupler in the upstream end, and one (identical, though rotated) HM coupler and one FM coupler in the downstream end (for their shapes and location see Figs. 1, 2) [1]. The cavity is 1.1 m long, the iris radius 35 mm, and the coupler beam pipe radius 39 mm. Note that the couplers reach closer to the axis than the irises, down to a distance of 30 mm

  4. Three-Tesla MRI does not improve the diagnosis of multiple sclerosis: A multicenter study.

    Science.gov (United States)

    Hagens, Marloes H J; Burggraaff, Jessica; Kilsdonk, Iris D; de Vos, Marlieke L; Cawley, Niamh; Sbardella, Emilia; Andelova, Michaela; Amann, Michael; Lieb, Johanna M; Pantano, Patrizia; Lissenberg-Witte, Birgit I; Killestein, Joep; Oreja-Guevara, Celia; Ciccarelli, Olga; Gasperini, Claudio; Lukas, Carsten; Wattjes, Mike P; Barkhof, Frederik

    2018-06-20

    In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). We recruited 66 patients with CIS within 6 months from symptom onset and 26 healthy controls in 6 MS centers. All participants underwent 1.5T and 3T brain and spinal cord MRI at baseline according to local optimized protocols and the MAGNIMS guidelines. Patients who had not converted to MS during follow-up received repeat brain MRI at 3-6 months and 12-15 months. The number of lesions per anatomical region was scored by 3 raters in consensus. Criteria for dissemination in space (DIS) and dissemination in time (DIT) were determined according to the 2017 revisions of the McDonald criteria. Three-Tesla MRI detected 15% more T2 brain lesions compared to 1.5T ( p Tesla MRI did not lead to a higher number of patients fulfilling the criteria for DIS or DIT, or subsequent diagnosis of MS, at any of the 3 time points. Scanning at 3T does not influence the diagnosis of MS according to McDonald diagnostic criteria. Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  5. 7 Tesla proton magnetic resonance spectroscopic imaging in adult X-linked adrenoleukodystrophy

    Science.gov (United States)

    Ratai, Eva; Kok, Trina; Wiggins, Christopher; Wiggins, Graham; Grant, Ellen; Gagoski, Borjan; O'Neill, Gilmore; Adalsteinsson, Elfar; Eichler, Florian

    2010-01-01

    Background Adult patients with X-linked adrenoleukodystrophy (X-ALD) remain at risk for progressive neurological deterioration. Phenotypes vary in their pathology, ranging from axonal degeneration to inflammatory demyelination. The severity of symptoms is poorly explained by conventional imaging. Objective To test the hypothesis that neurochemistry in normal appearing brain differs among adult phenotypes of X-ALD, and that neurochemical changes correlate with the severity of symptoms. Patients and Methods Using a 7 Tesla scanner we performed structural and proton MRSI in 13 adult patients with X-ALD, including 4 patients with adult cerebral ALD (ACALD), 5 with adrenomyeloneuropathy (AMN) and 4 female heterozygotes. Studies were also performed in nine healthy controls. Results Among adult X-ALD phenotypes, MI/Cr was 46% higher and Cho/Cr 21% higher in normal appearing white matter of ACALD compared to AMN (p Tesla proton MRSI reveals differences in the neurochemistry of ACALD but is unable to distinguish AMN from female heterozygotes. MI/Cr correlates with the severity of the symptoms and may be a meaningful biomarker in adult X-ALD. PMID:19001168

  6. Detection of glucose in the human brain with 1 H MRS at 7 Tesla.

    Science.gov (United States)

    Kaiser, Lana G; Hirokazu, Kawaguchi; Fukunaga, Masaki; B Matson, Gerald

    2016-12-01

    A new method is proposed for noninvasive detection of glucose in vivo using proton MR spectroscopy at 7 Tesla. The proposed method utilizes J-difference editing to uncover the resonance of beta-glucose (β-glc) at 3.23 ppm, which is strongly overlapped with choline. Calculations using the density matrix formalism are used to maximize the signal-to-noise ratio of the β-glc resonance at 3.23 ppm. The calculations are verified using phantom and in vivo data collected at 7 Tesla. The proposed method allows observation of the glucose signal at 3.23 ppm in the human brain spectrum. Additional co-edited resonances of N-acetylaspartylglutamatate and glutathione are also detected in the same experiment. The proposed method does not require carbon ( 13 C)- labeled glucose injections and 13 C hardware; as such, it has a potential to provide valuable information on intrinsic glucose concentration in the human brain in vivo. Magn Reson Med 76:1653-1660, 2016. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  7. A time-efficient acquisition protocol for multipurpose diffusion-weighted microstructural imaging at 7 Tesla.

    Science.gov (United States)

    Sepehrband, Farshid; O'Brien, Kieran; Barth, Markus

    2017-12-01

    Several diffusion-weighted MRI techniques have been developed and validated during the past 2 decades. While offering various neuroanatomical inferences, these techniques differ in their proposed optimal acquisition design, preventing clinicians and researchers benefiting from all potential inference methods, particularly when limited time is available. This study reports an optimal design that enables for a time-efficient diffusion-weighted MRI acquisition scheme at 7 Tesla. The primary audience of this article is the typical end user, interested in diffusion-weighted microstructural imaging at 7 Tesla. We tested b-values in the range of 700 to 3000 s/mm 2 with different number of angular diffusion-encoding samples, against a data-driven "gold standard." The suggested design is a protocol with b-values of 1000 and 2500 s/mm 2 , with 25 and 50 samples, uniformly distributed over two shells. We also report a range of protocols in which the results of fitting microstructural models to the diffusion-weighted data had high correlation with the gold standard. We estimated minimum acquisition requirements that enable diffusion tensor imaging, higher angular resolution diffusion-weighted imaging, neurite orientation dispersion, and density imaging and white matter tract integrity across whole brain with isotropic resolution of 1.8 mm in less than 11 min. Magn Reson Med 78:2170-2184, 2017. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

  8. In vivo sensitivity estimation and imaging acceleration with rotating RF coil arrays at 7 Tesla.

    Science.gov (United States)

    Li, Mingyan; Jin, Jin; Zuo, Zhentao; Liu, Feng; Trakic, Adnan; Weber, Ewald; Zhuo, Yan; Xue, Rong; Crozier, Stuart

    2015-03-01

    Using a new rotating SENSitivity Encoding (rotating-SENSE) algorithm, we have successfully demonstrated that the rotating radiofrequency coil array (RRFCA) was capable of achieving a significant reduction in scan time and a uniform image reconstruction for a homogeneous phantom at 7 Tesla. However, at 7 Tesla the in vivo sensitivity profiles (B1(-)) become distinct at various angular positions. Therefore, sensitivity maps at other angular positions cannot be obtained by numerically rotating the acquired ones. In this work, a novel sensitivity estimation method for the RRFCA was developed and validated with human brain imaging. This method employed a library database and registration techniques to estimate coil sensitivity at an arbitrary angular position. The estimated sensitivity maps were then compared to the acquired sensitivity maps. The results indicate that the proposed method is capable of accurately estimating both magnitude and phase of sensitivity at an arbitrary angular position, which enables us to employ the rotating-SENSE algorithm to accelerate acquisition and reconstruct image. Compared to a stationary coil array with the same number of coil elements, the RRFCA was able to reconstruct images with better quality at a high reduction factor. It is hoped that the proposed rotation-dependent sensitivity estimation algorithm and the acceleration ability of the RRFCA will be particularly useful for ultra high field MRI. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Total mass difference statistics algorithm: a new approach to identification of high-mass building blocks in electrospray ionization Fourier transform ion cyclotron mass spectrometry data of natural organic matter.

    Science.gov (United States)

    Kunenkov, Erast V; Kononikhin, Alexey S; Perminova, Irina V; Hertkorn, Norbert; Gaspar, Andras; Schmitt-Kopplin, Philippe; Popov, Igor A; Garmash, Andrew V; Nikolaev, Evgeniy N

    2009-12-15

    The ultrahigh-resolution Fourier transform ion cyclotron resonance (FTICR) mass spectrum of natural organic matter (NOM) contains several thousand peaks with dozens of molecules matching the same nominal mass. Such a complexity poses a significant challenge for automatic data interpretation, in which the most difficult task is molecular formula assignment, especially in the case of heavy and/or multielement ions. In this study, a new universal algorithm for automatic treatment of FTICR mass spectra of NOM and humic substances based on total mass difference statistics (TMDS) has been developed and implemented. The algorithm enables a blind search for unknown building blocks (instead of a priori known ones) by revealing repetitive patterns present in spectra. In this respect, it differs from all previously developed approaches. This algorithm was implemented in designing FIRAN-software for fully automated analysis of mass data with high peak density. The specific feature of FIRAN is its ability to assign formulas to heavy and/or multielement molecules using "virtual elements" approach. To verify the approach, it was used for processing mass spectra of sodium polystyrene sulfonate (PSS, M(w) = 2200 Da) and polymethacrylate (PMA, M(w) = 3290 Da) which produce heavy multielement and multiply-charged ions. Application of TMDS identified unambiguously monomers present in the polymers consistent with their structure: C(8)H(7)SO(3)Na for PSS and C(4)H(6)O(2) for PMA. It also allowed unambiguous formula assignment to all multiply-charged peaks including the heaviest peak in PMA spectrum at mass 4025.6625 with charge state 6- (mass bias -0.33 ppm). Application of the TMDS-algorithm to processing data on the Suwannee River FA has proven its unique capacities in analysis of spectra with high peak density: it has not only identified the known small building blocks in the structure of FA such as CH(2), H(2), C(2)H(2)O, O but the heavier unit at 154.027 amu. The latter was

  10. Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla. Technical development

    International Nuclear Information System (INIS)

    Sala, Evis; Priest, Andrew N.; Kataoka, Masako; Graves, Martin J.; Joubert, Ilse; Lomas, David J.; McLean, Mary A.; Griffiths, John R.; Crawford, Robin A.F.; Jimenez-Linan, Mercedes; Earl, Helena M.; Brenton, James D.

    2010-01-01

    This prospective study aims to evaluate the feasibility of DWI at 3 Tesla in patients with advanced ovarian cancer and investigate the differences in vascular signal fraction (VSF) and apparent diffusion coefficient (ADC) values between primary ovarian mass and metastatic disease. Twenty patients with suspected advanced ovarian carcinoma were enrolled in the study. High-resolution T2W FRFSE images were used to confirm the position of three marker lesions: primary ovarian mass, omental cake and peritoneal deposit. Multislice DWI was acquired in a single breath-hold using multiple b-values. The three marker lesions were outlined by an experienced radiologist on ADC and VSF maps. Ovarian lesions showed the highest ADC values. The mean ADC value for peritoneal deposits was significantly lower than for both ovarian lesions (p = 0.03) and omental cake (p = 0.03). The VSF for omental cake was significantly higher than for ovarian lesions (p = 0.01) and peritoneal deposits (p = 0.04). There was a significant positive correlation between ADC and VSF for peritoneal deposits (p = 0.04). DWI in advanced ovarian cancer is feasible at 3 T. There are significant differences in baseline ADC and VSF values between ovarian cancer, omental cake and peritoneal deposits that may explain the mixed treatment response that occurs at different disease sites. (orig.)

  11. Comparison of different undulator schemes with superimposed alternating gradients for the VUV-FEL at the TESLA Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    Pflueger, J.; Nikitina, Y.M. [DESY/HASYLAB, Hamburg (Germany)

    1995-12-31

    For the VUV-FEL at the TESLA Test Facility an undulator with a total length of 30 m is needed. In this study three different approaches to realize an undulator with a sinusoidal plus a superimposed quadrupolar field were studied with the 3D code MAFIA.

  12. PLACD-7T Study: Atherosclerotic Carotid Plaque Components Correlated with Cerebral Damage at 7 Tesla Magnetic Resonance Imaging.

    Science.gov (United States)

    den Hartog, A G; Bovens, S M; Koning, W; Hendrikse, J; Pasterkamp, G; Moll, F L; de Borst, G J

    2011-02-01

    In patients with carotid artery stenosis histological plaque composition is associated with plaque stability and with presenting symptomatology. Preferentially, plaque vulnerability should be taken into account in pre-operative work-up of patients with severe carotid artery stenosis. However, currently no appropriate and conclusive (non-) invasive technique to differentiate between the high and low risk carotid artery plaque in vivo is available. We propose that 7 Tesla human high resolution MRI scanning will visualize carotid plaque characteristics more precisely and will enable correlation of these specific components with cerebral damage. The aim of the PlaCD-7T study is 1: to correlate 7T imaging with carotid plaque histology (gold standard); and 2: to correlate plaque characteristics with cerebral damage ((clinically silent) cerebral (micro) infarcts or bleeds) on 7 Tesla high resolution (HR) MRI. We propose a single center prospective study for either symptomatic or asymptomatic patients with haemodynamic significant (70%) stenosis of at least one of the carotid arteries. The Athero-Express (AE) biobank histological analysis will be derived according to standard protocol. Patients included in the AE and our prospective study will undergo a pre-operative 7 Tesla HR-MRI scan of both the head and neck area. We hypothesize that the 7 Tesla MRI scanner will allow early identification of high risk carotid plaques being associated with micro infarcted cerebral areas, and will thus be able to identify patients with a high risk of periprocedural stroke, by identification of surrogate measures of increased cardiovascular risk.

  13. Implementation of fast macromolecular proton fraction mapping on 1.5 and 3 Tesla clinical MRI scanners: preliminary experience

    Science.gov (United States)

    Yarnykh, V.; Korostyshevskaya, A.

    2017-08-01

    Macromolecular proton fraction (MPF) is a biophysical parameter describing the amount of macromolecular protons involved into magnetization exchange with water protons in tissues. MPF represents a significant interest as a magnetic resonance imaging (MRI) biomarker of myelin for clinical applications. A recent fast MPF mapping method enabled clinical translation of MPF measurements due to time-efficient acquisition based on the single-point constrained fit algorithm. However, previous MPF mapping applications utilized only 3 Tesla MRI scanners and modified pulse sequences, which are not commonly available. This study aimed to test the feasibility of MPF mapping implementation on a 1.5 Tesla clinical scanner using standard manufacturer’s sequences and compare the performance of this method between 1.5 and 3 Tesla scanners. MPF mapping was implemented on 1.5 and 3 Tesla MRI units of one manufacturer with either optimized custom-written or standard product pulse sequences. Whole-brain three-dimensional MPF maps obtained from a single volunteer were compared between field strengths and implementation options. MPF maps demonstrated similar quality at both field strengths. MPF values in segmented brain tissues and specific anatomic regions appeared in close agreement. This experiment demonstrates the feasibility of fast MPF mapping using standard sequences on 1.5 T and 3 T clinical scanners.

  14. Dynamic contrast-enhanced breast MRI at 7 Tesla utilizing a single-loop coil: a feasibility trial.

    Science.gov (United States)

    Umutlu, Lale; Maderwald, Stefan; Kraff, Oliver; Theysohn, Jens M; Kuemmel, Sherko; Hauth, Elke A; Forsting, Michael; Antoch, Gerald; Ladd, Mark E; Quick, Harald H; Lauenstein, Thomas C

    2010-08-01

    The aim of this study was to assess the feasibility of dynamic contrast-enhanced ultra-high-field breast imaging at 7 Tesla. A total of 15 subjects, including 5 patients with histologically proven breast cancer, were examined on a 7 Tesla whole-body magnetic resonance imaging system using a unilateral linearly polarized single-loop coil. Subjects were placed in prone position on a biopsy support system, with the coil placed directly below the region of interest. The examination protocol included the following sequences: 1) T2-weighted turbo spin echo sequence; 2) six dynamic T1-weighted spoiled gradient-echo sequences; and 3) subtraction imaging. Contrast-enhanced T1-weighted imaging at 7 Tesla could be obtained at high spatial resolution with short acquisition times, providing good image accuracy and a conclusively good delineation of small anatomical and pathological structures. T2-weighted imaging could be obtained with high spatial resolution at adequate acquisition times. Because of coil limitations, four high-field magnetic resonance examinations showed decreased diagnostic value. This first scientific approach of dynamic contrast-enhanced breast magnetic resonance imaging at 7 Tesla demonstrates the complexity of ultra-high-field breast magnetic resonance imaging and countenances the implementation of further advanced bilateral coil concepts to circumvent current limitations from the coil and ultra-high-field magnetic strength. 2010 AUR. Published by Elsevier Inc. All rights reserved.

  15. Image quality and cancer visibility of T2-weighted Magnetic Resonance Imaging of the prostate at 7 Tesla

    NARCIS (Netherlands)

    Vos, E.K.; Lagemaat, M.W.; Barentsz, J.O.; Futterer, J.J.; Zamecnik, P.; Roozen, H.; Orzada, S.; Bitz, A.K.; Maas, M.C.; Scheenen, T.W.J.

    2014-01-01

    To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T).Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored

  16. Spatial Distortion in MRI-Guided Stereotactic Procedures: Evaluation in 1.5-, 3- and 7-Tesla MRI Scanners.

    Science.gov (United States)

    Neumann, Jan-Oliver; Giese, Henrik; Biller, Armin; Nagel, Armin M; Kiening, Karl

    2015-01-01

    Magnetic resonance imaging (MRI) is replacing computed tomography (CT) as the main imaging modality for stereotactic transformations. MRI is prone to spatial distortion artifacts, which can lead to inaccuracy in stereotactic procedures. Modern MRI systems provide distortion correction algorithms that may ameliorate this problem. This study investigates the different options of distortion correction using standard 1.5-, 3- and 7-tesla MRI scanners. A phantom was mounted on a stereotactic frame. One CT scan and three MRI scans were performed. At all three field strengths, two 3-dimensional sequences, volumetric interpolated breath-hold examination (VIBE) and magnetization-prepared rapid acquisition with gradient echo, were acquired, and automatic distortion correction was performed. Global stereotactic transformation of all 13 datasets was performed and two stereotactic planning workflows (MRI only vs. CT/MR image fusion) were subsequently analysed. Distortion correction on the 1.5- and 3-tesla scanners caused a considerable reduction in positional error. The effect was more pronounced when using the VIBE sequences. By using co-registration (CT/MR image fusion), even a lower positional error could be obtained. In ultra-high-field (7 T) MR imaging, distortion correction introduced even higher errors. However, the accuracy of non-corrected 7-tesla sequences was comparable to CT/MR image fusion 3-tesla imaging. MRI distortion correction algorithms can reduce positional errors by up to 60%. For stereotactic applications of utmost precision, we recommend a co-registration to an additional CT dataset. © 2015 S. Karger AG, Basel.

  17. The Grenoble station for producing strong transient magnetic fields higher than 100 teslas by an explosive driven flux compression

    International Nuclear Information System (INIS)

    Guillot, M.

    1976-01-01

    Reproducible transient magnetic fields up to 400 teslas (4 megaoersted) are achieved by a simple explosive driven flux compression. The results are described simply from the point of view of energy conversion. The problems of field measurements are studied: the precision is +-2% with a field cavity of 5 mm diameter [fr

  18. Blood Flow and Brain Function: Investigations of neurovascular coupling using BOLD fMRI at 7 tesla

    NARCIS (Netherlands)

    Siero, J.C.W.

    2013-01-01

    The advent of ultra high field (7 tesla) MRI systems has opened the possibility to probe biological processes of the human body in great detail. Especially for studying brain function using BOLD fMRI there is a large benefit from the increased magnetic field strength. BOLD fMRI is the working horse

  19. In vivo 1H spectroscopy of the human brain at 1.5 tesla. Preliminary experience at a clinical installation

    DEFF Research Database (Denmark)

    Henriksen, O; Larsson, H; Jensen, K M

    1990-01-01

    In vivo localized water suppressed proton spectroscopy of human brain was carried out on 15 healthy volunteers and 2 patients suffering from a brain tumour and an infarction, respectively. The measurements were performed on a whole body MR system, operating at 1.5 tesla using the stimulated echo...

  20. Design considerations and analysis of potential applications of a high power ultraviolet FEL at the TESLA test facility at DESY

    International Nuclear Information System (INIS)

    Pagani, C.; Saldin, E.L.; Schneidmiller, E.A.; Yurkov, M.V.

    1999-01-01

    A possibility of constructing a high power ultraviolet free electron laser at the TESLA test facility at DESY is discussed. The proposed facility consists of a tunable master oscillator (P av ∼10 mW, P peak ∼10 kW, λ≅200-350 nm) and an FEL amplifier with a tapered undulator. The average and peak radiation power at the exit of the FEL amplifier is about 7 kW and 220 GW, respectively. Installation of such a facility can significantly extend scientific potential of the TESLA test facility. The UV free electron laser can be used to construct a polarized, monochromatic gamma-source with the ultimate yield up to 10 12 gamma-quanta per second and the maximal energy of about 100 MeV. An intensive gamma-source can also form the base for constructing the test facility for the TESLA positron generation system. Another accelerator application of the proposed facility is verification of the main technical solutions for the laser and the optical system to be used in the gamma-gamma option of the TESLA collider. A high average power UV laser is also promising for industrial applications

  1. Diffusion-weighted whole-body MR imaging with background body signal suppression: a feasibility study at 3.0 Tesla

    International Nuclear Information System (INIS)

    Muertz, Petra; Krautmacher, Carsten; Traeber, Frank; Schild, Hans H.; Willinek, Winfried A.; Gieseke, Juergen

    2007-01-01

    The purpose was to provide a diffusion-weighted whole-body magnetic resonance (MR) imaging sequence with background body signal suppression (DWIBS) at 3.0 Tesla. A diffusion-weighted spin-echo echo-planar imaging sequence was combined with the following methods of fat suppression: short TI inversion recovery (STIR), spectral attenuated inversion recovery (SPAIR), and spectral presaturation by inversion recovery (SPIR). Optimized sequences were implemented on a 3.0- and a 1.5-Tesla system and evaluated in three healthy volunteers and six patients with various lesions in the neck, chest, and abdomen on the basis of reconstructed maximum intensity projection images. In one patient with metastases of malignant melanoma, DWIBS was compared with 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET). Good fat suppression for all regions and diagnostic image quality in all cases could be obtained at 3.0 Tesla with the STIR method. In comparison with 1.5 Tesla, DWIBS images at 3.0 Tesla were judged to provide a better lesion-to-bone tissue contrast. However, larger susceptibility-induced image distortions and signal intensity losses, stronger blurring artifacts, and more pronounced motion artifacts degraded the image quality at 3.0 Tesla. A good correlation was found between the metastases as depicted by DWIBS and those as visualized by FDG-PET. DWIBS is feasible at 3.0 Tesla with diagnostic image quality. (orig.)

  2. Beam orbit control in TESLA superconducting cavities from dipole mode measurements

    International Nuclear Information System (INIS)

    Paparella, R.

    2006-09-01

    The knowledge of the electromagnetic interaction between a beam and the surrounding vacuum chamber is necessary in order to optimize the accelerator performance in terms of stored current. Many instability phenomena may occur in the machine because of the fields produced by the beam and acting back on itself. Basically, these fields, wake-fields, produce an extra voltage, affecting the longitudinal dynamics, and a transverse kick which deflects the beam. In this thesis we present the results of theoretical and experimental investigations to demonstrate the possibility of using the dipolar wake fields of the superconducting accelerating to measure the beam transverse position. After an introduction to the ILC project and to the TESLA technology, of superconducting RF cavities, we will approach the problem from an analytical point of view in chapter 2. The expression of the wake fields in a cylindrical cavity will be investigated and the electromagnetic field modes derived from Maxwell equations in an original way. Graphical solutions of a Matlab program simulating the fields due to a particle passing through a pill-box cavity along a generic path will be shown. The interaction of the beam with higher order modes (HOM) in the TESLA cavities has been studied in the past at the TESLA Test Facility (TTF) in order to determine whether the modes with the highest loss factor are sufficiently damped. Starting from the results obtained before 2003, HOM signals has been better observed and examined in order to use dipole modes to find the electric center of each cavity in the first TTF accelerating module. The results presented in chapter 3 will show that by monitoring the HOM signal amplitude for two polarizations of a dipole mode, one can measure electrical center of the modes with a resolution of 50 μm. Moreover, a misalignment of the first TTF module with respect to the gun axis has been predicted using cavity dipole modes. Alternatives to this method are described in

  3. Surface Induced Dissociation Coupled with High Resolution Mass Spectrometry Unveils Heterogeneity of a 211 kDa Multicopper Oxidase Protein Complex

    Science.gov (United States)

    Zhou, Mowei; Yan, Jing; Romano, Christine A.; Tebo, Bradley M.; Wysocki, Vicki H.; Paša-Tolić, Ljiljana

    2018-01-01

    Manganese oxidation is an important biogeochemical process that is largely regulated by bacteria through enzymatic reactions. However, the detailed mechanism is poorly understood due to challenges in isolating and characterizing these unknown enzymes. A manganese oxidase, Mnx, from Bacillus sp. PL-12 has been successfully overexpressed in active form as a protein complex with a molecular mass of 211 kDa. We have recently used surface induced dissociation (SID) and ion mobility-mass spectrometry (IM-MS) to release and detect folded subcomplexes for determining subunit connectivity and quaternary structure. The data from the native mass spectrometry experiments led to a plausible structural model of this multicopper oxidase, which has been difficult to study by conventional structural biology methods. It was also revealed that each Mnx subunit binds a variable number of copper ions. Becasue of the heterogeneity of the protein and limited mass resolution, ambiguities in assigning some of the observed peaks remained as a barrier to fully understanding the role of metals and potential unknown ligands in Mnx. In this study, we performed SID in a modified Fourier transform-ion cyclotron resonance (FTICR) mass spectrometer. The high mass accuracy and resolution offered by FTICR unveiled unexpected artificial modifications on the protein that had been previously thought to be iron bound species based on lower resolution spectra. Additionally, isotopically resolved spectra of the released subcomplexes revealed the metal binding stoichiometry at different structural levels. This method holds great potential for in-depth characterization of metalloproteins and protein-ligand complexes. [Figure not available: see fulltext.

  4. Comparison of Pelvic Phased-Array versus Endorectal Coil Magnetic Resonance Imaging at 3 Tesla for Local Staging of Prostate Cancer

    OpenAIRE

    Kim, Bum Soo; Kim, Tae-Hwan; Kwon, Tae Gyun; Yoo, Eun Sang

    2012-01-01

    Purpose Several studies have demonstrated the superiority of endorectal coil magnetic resonance imaging (MRI) over pelvic phased-array coil MRI at 1.5 Tesla for local staging of prostate cancer. However, few have studied which evaluation is more accurate at 3 Tesla MRI. In this study, we compared the accuracy of local staging of prostate cancer using pelvic phased-array coil or endorectal coil MRI at 3 Tesla. Materials and Methods Between January 2005 and May 2010, 151 patients underwent radi...

  5. High-resolution, in vivo magnetic resonance imaging of Drosophila at 18.8 Tesla.

    Directory of Open Access Journals (Sweden)

    Brian Null

    Full Text Available High resolution MRI of live Drosophila was performed at 18.8 Tesla, with a field of view less than 5 mm, and administration of manganese or gadolinium-based contrast agents. This study demonstrates the feasibility of MR methods for imaging the fruit fly Drosophila with an NMR spectrometer, at a resolution relevant for undertaking future studies of the Drosophila brain and other organs. The fruit fly has long been a principal model organism for elucidating biology and disease, but without capabilities like those of MRI. This feasibility marks progress toward the development of new in vivo research approaches in Drosophila without the requirement for light transparency or destructive assays.

  6. FPGA and optical-network-based LLRF distributed control system for TESLA-XFEL linear accelerator

    Science.gov (United States)

    Pozniak, Krzysztof T.; Romaniuk, Ryszard S.; Czarski, Tomasz; Giergusiewicz, Wojciech; Jalmuzna, Wojciech; Olowski, Krysztof; Perkuszewski, Karol; Zielinski, Jerzy; Simrock, Stefan

    2005-02-01

    The work presents a structural and functional model of a distributed low level radio frequency (LLRF) control system for the TESLA-XFEL accelerator. The design of a system basing on the FPGA chips and multi-gigabit optical network was debated. The system design approach was fully parametric. The major emphasis is put on the methods of the functional and hardware concentration to use fully both: a very big transmission capacity of the optical fiber telemetric channels and very big processing power of the latest series of the, DSP enhanced and optical I/O equipped, FPGA chips. The subject of the work is the design of a universal, laboratory module of the LLRF sub-system. Initial parameters of the system model under the design are presented.

  7. Magnet Design and Analysis of a 40 Tesla Long Pulse System Energized by a Battery Bank

    Science.gov (United States)

    Lv, Y. L.; Peng, T.; Wang, G. B.; Ding, T. H.; Han, X. T.; Pan, Y.; Li, L.

    2013-03-01

    A 40 tesla long pulse magnet and a battery bank as the power supply have been designed. This is now under construction at the Wuhan National High Magnetic Field Center. The 22 mm bore magnet will generate smooth pulses with duration 1 s and rise time 0.5 s. The battery bank consists of 945 12V/200 Ah lead-acid battery cells. The magnet and battery bank were optimized by codes developed in-house and by ANSYS. The coil was made from soft copper with internal reinforcement by fiber-epoxy composite; it is divided into two sections connected in series. The inner section consists of helix coils with each layer reinforced by Zylon composite. The outer section will be wound from copper sheet and externally reinforced by carbon fiber composite.

  8. A test of a 2 Tesla superconducting transmission line magnet system

    International Nuclear Information System (INIS)

    Piekarz, Henryk; Carcagno, Ruben; Claypool, Brad; Foster, George W.; Hays, Steven L.; Huang, Yuenian; Kashikhin, Vladimir; Malamud, Ernest; Mazur, Peter O.; Nehring, Roger; Oleck, Andrew; Rabehl, Roger; Schlabach, Phil; Sylvester, Cosmore; Velev, Gueorgui; Volk, James; Wake, Masayoshi

    2005-01-01

    Superconducting transmission line magnet test system for an injector accelerator of a staged VLHC proton-proton colliding beam accelerator has been built and operated at Fermilab. The 1.5 m long, twin-aperture, combined function dipole magnet of 2 Tesla field is excited by a single turn 100 kA transmission line superconductor. The 100 kA dc current is generated using dc-dc switching converters powered by a bulk 240 kW supply. A pair of horizontally placed conventional leads facilitates transfer of this current to the magnet transmission line superconductor operating at liquid helium temperature. Fabrication of magnet components and magnet assembly work are described. The magnet test system and its operation are presented, and the performance is summarized

  9. A test of a 2 Tesla superconducting transmission line magnet system

    Energy Technology Data Exchange (ETDEWEB)

    Piekarz, Henryk; Carcagno, Ruben; Claypool, Brad; Foster, George W.; Hays, Steven L.; Huang, Yuenian; Kashikhin, Vladimir; Malamud, Ernest; Mazur, Peter O.; Nehring,; Oleck, Andrew; Rabehl, Roger; Schlabach, Phil; Sylvester, Cosmore; Velev, Gueorgui; Volk, James; /Fermilab; Wake, Masayoshi; /KEK, Tsukuba

    2005-09-01

    Superconducting transmission line magnet test system for an injector accelerator of a staged VLHC proton-proton colliding beam accelerator has been built and operated at Fermilab. The 1.5 m long, twin-aperture, combined function dipole magnet of 2 Tesla field is excited by a single turn 100 kA transmission line superconductor. The 100 kA dc current is generated using dc-dc switching converters powered by a bulk 240 kW supply. A pair of horizontally placed conventional leads facilitates transfer of this current to the magnet transmission line superconductor operating at liquid helium temperature. Fabrication of magnet components and magnet assembly work are described. The magnet test system and its operation are presented, and the performance is summarized.

  10. D-zero rototrack: first stage of D-zero 2 Tesla solenoid field mapping device

    International Nuclear Information System (INIS)

    Yamada, R.; Korienek, J.; Krider, J.; Lindenmeyer, C.; Miksa, D.; Miksa, R.

    1997-09-01

    A simple and portable field mapping device was developed at Fermilab and successfully used to test the D0 2 Tesla solenoid at Toshiba Works in Japan. A description of the mechanical structure, electric driving and control system, and software of the field mapping device is given. Four Hall probe elements of Group3 Digital Gaussmeters are mounted on the radial extension arm of a carriage, which is mounted on a central rotating beam. The system gives two dimensional motions (axial and rotational) to the Hall probes. To make the system compact and portable, we used a laptop computer with PCMCIA cards. For the control system we used commercially available software LabVIEW and Motion Toolbox, and for the data analysis we used Microsoft Excel

  11. Start-to-end simulations of SASE FEL at the TESLA Test Facility

    International Nuclear Information System (INIS)

    Dohlus, M.; Floettmann, K.; Limberg, T.; Saldin, E.L; Schneidmiller, E.A.; Kozlov, O.S.; Yurkov, M.V.; Piot, Ph.

    2004-01-01

    VUV SASE FEL at the TESLA Test Facility (Phase 1) was successfully running and reached saturation in the wavelength range 80-120 nm. We present a posteriori start-to-end simulations of this machine. The codes Astra and elegant are used to track particle distribution from the cathode to the undulator entrance. An independent simulation of the beam dynamics in the bunch compressor is performed with the code CSRtrack. SASE FEL process is simulated with the code FAST. The simulation results are in good agreement with the measured properties of SASE FEL radiation. It is shown that the beam dynamics after the bunch compressor is mainly defined by space charge fields. FEL radiation is produced by the head of the electron bunch having a peak current of about 3 kA and a duration of 100 fs

  12. 3Tesla magnetic resonance examination of a patient suffering from diffuse axonal injury

    International Nuclear Information System (INIS)

    Bonchev, S.; Zlatareva, D.; Hadjidekov, V.

    2016-01-01

    Diffuse axonal injury has been observed in traumatic brain injury. Both type of lesions - haemorrhagic and non-haemorrhagic, demonstrate on MRI. We would like to introduce you a 24 year old outpatient man, who was examined in our Department with a past medical history of severe traumatic brain injury, followed by two weeks of coma in Intensive care, discharged from hospital with good outcome. Subsequently cognitive impairments have developed and an episode of tonic-clonic seizure have been undergone by the patient. 3Tesla MRI was performed and lesions typical for diffuse axonal injury were found. MRI is the study of choice for demonstrating the lesions of diffuse axonal injury in the acute and chronic period

  13. Effect of magnetic flux-densities of up to 0.1 Tesla on copper electrodeposition

    International Nuclear Information System (INIS)

    Cifuentes, L.; Artigas, M.; Riveros, G.; Warczok, A.

    2003-01-01

    The effect of magnetic flux densities (B) between 0.0 and 0.1 Tesla on cathode and anode over potentials, cell voltage and electro deposit quality was determined fro a lab-scale copper electrowinning cell which operates at industrial current, density values. Cell voltage decreases with increasing B. The cathodic overpotential decreases by 30% when B increases from 0.0 to 0.1 T. The anodic overpotential also decreases with increasing B, but this effect is six times less than the corresponding effect on the cathodic overpotential. Cathodic effects can be predicted by an expression derived from electrochemical kinetics and magnetohydrodynamic theory. Anodic effects cannot be predicted in the same way. The size of grains and intergranular voids decreases and the surface of the electro deposit becomes smoother as B increases, which means that, in the studied conditions, the quality of the produced copper deposits improves. (Author) 26 refs

  14. Control system to a Rankine cycle with a Tesla turbine using arduino

    International Nuclear Information System (INIS)

    Medeiros, Josenei G.; Guimaraes, Lamartine F.; Placco, Guilherme M.

    2013-01-01

    The thermal Rankine cycle is a thermodynamic cycle which converts heat in energy. This cycle occurs in steady state, in other words the cycle is a closed loop circuit with continuous feedback, which guarantees the reuse process one energy transformed in the various stages of the cycle. This cycle is used to drive a turbine type TESLA designed for the system. The objective of this work is to create the control and automation of this cycle using an micro-controlled system with Arduino that will hold the collection of sensors and the system will act to maintain the balance of the cycle causing it to behave continuously and with less interference from human operation for maintenance. Data will be collected and further processed, where it will display all the sensors and the situation of the actuators involved. Using Arduino system ensures the stability and reliability with a low cost of implementation

  15. Could our nuclear vision benefit from a spell of Tesla magic?

    International Nuclear Information System (INIS)

    Shepherd, John

    2018-01-01

    As I put the finishing touches to this latest article, US entrepreneur and boss of the Tesla car giant, Elon Musk, successfully launched a new rocket, the Falcon Heavy, from the Kennedy Space Center in Florida. What this has to do with nuclear today? Technologically speaking nothing. But think 'outside the box' - as I'm sure many of you have been told in those corporate management-training classes. The answer is: 'vision'. The unabashed vision to be bold, daring, imaginative. The vision to believe in technology and to be unafraid to build on the experience and knowledge gained to date, including the failures, as we take the next steps forward.

  16. Simulations of the TESLA Linear Collider with a Fast Feedback System

    CERN Document Server

    Schulte, Daniel; White, G

    2003-01-01

    The tolerances on the beams as they collide at the interaction point of the TESLA linear collider are very tight due to the nano-metre scale final vertical bunch spot sizes. Ground motion causes the beams to increase in emittance and drift out of collision leading to dramatic degradation of luminosity performance. To combat this, both slow orbit and fast intra-train feedback systems will be used. The design of these feedback systems depends critically on how component misalignment effects the beam throughout the whole accelerator. A simulation has been set up to study in detail the accelerator performance under such conditions by merging the codes of PLACET, MERLIN and GUINEA-PIG together with Simulink code to model feedback systems, all under a Matlab environment.

  17. Quadrature Slotted Surface Coil Pair for Magnetic Resonance Imaging at 4 Tesla: Phantom Study

    Directory of Open Access Journals (Sweden)

    Solis S.E.

    2012-01-01

    Full Text Available A coil array was composed of two slotted surface coils forming a structure with two plates at 900, each one having 6 circular slots and is introduced in this paper. Numerical simulations of the magnetic field of this coil array were performed at 170 MHz using the finite element method to study its behaviour. This coil array was developed for brain magnetic resonance imaging to be operated at the resonant frequency of 170 MHz in the transceiver mode and quadrature driven. Numerical simulations demonstrated that electromagnetic interaction between the coil elements is negligible, and that the magnetic field showed a good uniformity. Phantom images were acquired with our coil array and standard pulse sequences on a research-dedicated 4 Tesla scanner. In vitro images showed the feasibility of this coil array for standard pulses and high field magnetic resonance imaging.

  18. A mechanically tunable and efficient ceramic probe for MR-microscopy at 17 Tesla

    Science.gov (United States)

    Kurdjumov, Sergei; Glybovski, Stanislav; Hurshkainen, Anna; Webb, Andrew; Abdeddaim, Redha; Ciobanu, Luisa; Melchakova, Irina; Belov, Pavel

    2017-09-01

    In this contribution we propose and study numerically a new probe (radiofrequency coil) for magnetic resonance mi-croscopy in the field of 17T. The probe is based on two coupled donut resonators made of a high-permittivity and low-loss ceramics excited by a non-resonant inductively coupled loop attached to a coaxial cable. By full-wave numerical simulation it was shown that the probe can be precisely tuned to the Larmor frequency of protons (723 MHz) by adjusting a gap between the two resonators. Moreover, the impedance of the probe can be matched by varying the distance from one of the resonators to the loop. As a result, a compact and mechanically tunable resonant probe was demonstrated for 17 Tesla applications using no lumped capacitors for tuning and matching. The new probe was numerically compared to a conventional solenoidal probe showing better efficiency.

  19. Bunch Compressor Beamlines for the Tesla and S Band Linear Colliders

    CERN Document Server

    Emma, P

    2003-01-01

    A detailed design for a single stage beam bunch length compressor for both the TESLA and the S-Band Linear Collider (SBLC) is presented. Compression is achieved by introducing an energy-position correlation along the bunch with an rf section at zero-crossing phase followed by a short bending section with energy dependent path length (momentum compaction). The motivation for a wiggler design is presented and many of the critical single bunch tolerances are evaluated. A solenoid based spin rotator is included in the design and transverse emittance tuning elements, diagnostics and tuning methods are described. Bunch length limitations due to second order momentum compaction and sinusoidal rf shape are discussed with options for compensation. Finally, the disadvantages of bunch compression using a 180 sup o arc are discussed.

  20. Specific heat of single crystalline YBa2Cu3O7 in 20 Tesla

    International Nuclear Information System (INIS)

    Bonjour, E.; Calemczuk, R.; Henry, J.Y.; Muller, J.; Triscone, G.; Vallier, J.C.

    1993-01-01

    The specific heat of a single crystal of YBa 2 Cu 3 0 7 is measured from 40 to 150 K in magnetic fields up to 20 Tesla applied either parallel or normal to the c axis. Adiabatic calorimetry with a scatter well below 0.1% is used. The scaling of the superconducting transitions determines the bulk anisotropy ratio 5.5±0.5. A Maki-like term is observed at intermediate temperatures. The unusual behaviour of YBa 2 Cu 3 0 7 in a field, featuring a considerable smearing of the transition and an apparently field-independent onset, may be qualitatively understood as a phenomenological consequence of the small and anisotropic value of the coherence length alone, using the relevant models of field-induced critical I-D fluctuations on one hand, and London-like regime for the mean-field part of the transition on the other hand

  1. Specific heat of single crystalline YBa2Cu3O7 in 20 Tesla

    International Nuclear Information System (INIS)

    Junod, A.; Bonjour, E.; Calemczuk, R.; Henry, J.Y.; Muller, J.; Triscone, G.; Vallier, J.C.

    1994-01-01

    The specific heat of a single crystal of YBa 2 Cu 3 O 7 is measured from 40 to 150 K in magnetic fields up to 20 Tesla applied either parallel or normal to the c axis. Adiabatic calorimetry with a scatter well below 0.1% is used. The scaling of the superconducting transitions determines the bulk anisotropy ratio, 5.5±0.5. A Maki-like term is observed at intermediate temperatures. The unusual behaviour of YBa 2 Cu 3 O 7 in a field, featuring a considerable smearing of the transition and an apparently field-independent onset, may be qualitatively understood as a phenomenological consequence of the small and anisotropic value of the coherence length alone, using the relevant models of field-induced critical 1-D fluctuations on one hand, and London-like regime for the mean-field part of the transition on the other hand. (orig.)

  2. Optoelectronics in TESLA, LHC and pi-of-the-sky experiments

    CERN Document Server

    Romaniuk, Ryszard; Simrock, Stefan; Wrochna, Grzegorz

    2004-01-01

    Optical and optoelectronics technologies are more and more widely used in the biggest world experiments of high energy and nuclear physics, as well as in the astronomy. The paper is a kind of a broad digest describing the usage of optoelectronics is such experiments and information about some of the involved teams. The described experiments include: TESLA linear accelerator and FEL, Compact Muon Solenoid at LHC and recently started pi-of-the-sky global gamma ray bursts (with associated optical flashes) observation experiment. Optoelectronics and photonics offer several key features which are either extending the technical parameters of existing solutions or adding quite new practical application possibilities. Some of these favorable features of photonic systems are: high selectivity of optical sensors, immunity to some kinds of noise processes, extremely broad bandwidth exchangeable for either terabit rate transmission or ultrashort pulse generation, parallel image processing capability, etc. The following g...

  3. Micromechanical ``Trampoline'' Magnetometers for Use in Pulsed Magnetic Fields Exceeding 60 Tesla

    Science.gov (United States)

    Balakirev, F. F.; Boebinger, G. S.; Aksyuk, V.; Gammel, P. L.; Haddon, R. C.; Bishop, D. J.

    1998-03-01

    We present the design, construction, and operation of a novel magnetometer for use in intense pulsed magnetic fields. The magnetometer consists of a silicon micromachined "trampoline" to which the sample is attached. The small size of the device (typically 400 microns on a side) gives a fast mechanical response (10,000 to 50,000 Hz) and extremely high sensitivity (10-11 Am^2, corresponding to 10-13 Am^2/Hz^(1/2)). The device is robust against electrical and mechanical noise and requires no special vibration isolation from the pulsed magnet. As a demonstration, we present data taken in a 60 tesla pulsed magnetic field which show clear de Haas-van Alphen oscillations in a one microgram sample of the organic superconductor K-(BEDT-TTF)_2Cu(NCS)_2.

  4. Control system to a Rankine cycle with a Tesla turbine using arduino

    Energy Technology Data Exchange (ETDEWEB)

    Medeiros, Josenei G., E-mail: joseneigodoi@yahoo.com.br [Faculdade de Tecnologia Sao Francisco (FATESF), Jacarei, SP (Brazil); Guimaraes, Lamartine F.; Placco, Guilherme M., E-mail: guimarae@ieav.cta.br, E-mail: placco@ieav.cta.br [Instituto de Estudos Avancados (ENU/IEAv/DCTA), Sao Jose dos Campos, SP (Brazil). Departamento de Energia Nuclear

    2013-07-01

    The thermal Rankine cycle is a thermodynamic cycle which converts heat in energy. This cycle occurs in steady state, in other words the cycle is a closed loop circuit with continuous feedback, which guarantees the reuse process one energy transformed in the various stages of the cycle. This cycle is used to drive a turbine type TESLA designed for the system. The objective of this work is to create the control and automation of this cycle using an micro-controlled system with Arduino that will hold the collection of sensors and the system will act to maintain the balance of the cycle causing it to behave continuously and with less interference from human operation for maintenance. Data will be collected and further processed, where it will display all the sensors and the situation of the actuators involved. Using Arduino system ensures the stability and reliability with a low cost of implementation.

  5. Magnetic field calculations for the technical proposal of the TESLA spectrometer magnet

    International Nuclear Information System (INIS)

    Morozov, N.A.; Schreiber, H.J.

    2003-01-01

    The TESLA electron-positron linear collider is under consideration at DESY (Hamburg). The realization of the physical program at this collider requires the knowledge of the beam energy of both beams (e + and e - ) with a precision of ΔE/E ≤ 10 -4 . The magnetic spectrometer was proposed as an energy measuring device. The report describes calculations for the preliminary conceptual design of this type of the spectrometer. The 2D calculations of the magnetic field for the spectrometer magnet have been performed by POISSON SUPERFISH computer code. The basic technical parameters of the magnet have been determined. These data will serve as a basis for the technical design of the spectrometer magnet and discuss its integration in the spectrometer

  6. Cryomodule tests of four Tesla-like cavities in the Superconducting RF Test Facility at KEK

    Directory of Open Access Journals (Sweden)

    Eiji Kako

    2010-04-01

    Full Text Available A 6-m cryomodule including four Tesla-like cavities was developed, and was tested in the Superconducting RF Test Facility phase-I at KEK. The performance as a total superconducting cavity system was checked in the cryomodule tests at 2 K with high rf power. One of the four cavities achieved a stable pulsed operation at 32  MV/m, which is higher than the operating accelerating gradient in the ILC. The maximum accelerating gradient (E_{acc,max⁡} obtained in the vertical cw tests was maintained or slightly improved in the cryomodule tests operating in a pulse mode. Compensation of the Lorentz force detuning at 31  MV/m was successfully demonstrated by a piezo tuner and predetuning.

  7. Diagnostics Upgrades for Investigations of HOM Effects in TESLA-type SCRF Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A. H. [Fermilab; Edstrom Jr., D.; Ruan, J. [Fermilab; Thurman-Keup, R. [Fermilab; Shin, Y. [Fermilab; Prieto, P. [Fermilab; Eddy, N. [Fermilab; Carlsten, B. E. [Los Alamos

    2017-08-23

    We describe the upgrades to diagnostic capabilities on the Fermilab Accelerator Science and Technology (FAST) electron linear accelerator that will allow investigations of the effects of high-order modes (HOMs) in SCRF cavities on macropulse-average beam quality. We examine the dipole modes in the first pass-band generally observed in the 1.6-1.9 GHz regime for TESLA-type SCRF cavities due to uniform transverse beam offsets of the electron beam. Such cavities are the basis of the accelerators such as the European XFEL and the proposed MaRIE XFEL facility. Preliminary HOM detector data, prototype BPM test data, and first framing camera OTR data with ~20- micron spatial resolution at 250 pC per bunch will be presented.

  8. Seven-Tesla Magnetization Transfer Imaging to Detect Multiple Sclerosis White Matter Lesions.

    Science.gov (United States)

    Chou, I-Jun; Lim, Su-Yin; Tanasescu, Radu; Al-Radaideh, Ali; Mougin, Olivier E; Tench, Christopher R; Whitehouse, William P; Gowland, Penny A; Constantinescu, Cris S

    2018-03-01

    Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesions, it has not been fully optimized for visualization of white matter lesions and thus has not been used for delineating lesions in quantitative magnetic resonance imaging (MRI) studies of the normal appearing white matter in multiple sclerosis. Therefore, we aimed to evaluate the sensitivity of 7T magnetization-transfer-weighted (MT w ) images in the detection of white matter lesions compared with 3T-FLAIR. Fifteen patients with clinically isolated syndrome, 6 with multiple sclerosis, and 10 healthy participants were scanned with 7T 3-dimensional (D) MT w and 3T-2D-FLAIR sequences on the same day. White matter lesions visible on either sequence were delineated. Of 662 lesions identified on 3T-2D-FLAIR images, 652 were detected on 7T-3D-MT w images (sensitivity, 98%; 95% confidence interval, 97% to 99%). The Spearman correlation coefficient between lesion loads estimated by the two sequences was .910. The intrarater and interrater reliability for 7T-3D-MT w images was good with an intraclass correlation coefficient (ICC) of 98.4% and 81.8%, which is similar to that for 3T-2D-FLAIR images (ICC 96.1% and 96.7%). Seven-Tesla MT w sequences detected most of the white matter lesions identified by FLAIR at 3T. This suggests that 7T-MT w imaging is a robust alternative for detecting demyelinating lesions in addition to 3T-FLAIR. Future studies need to compare the roles of optimized 7T-FLAIR and of 7T-MT w imaging. © 2017 The Authors. Journal of Neuroimaging published by Wiley Periodicals, Inc. on behalf of American Society of Neuroimaging.

  9. BOLD cardiovascular magnetic resonance at 3.0 tesla in myocardial ischemia

    Directory of Open Access Journals (Sweden)

    Gebker Rolf

    2010-09-01

    Full Text Available Abstract Background The purpose of this study was to determine the ability of Blood Oxygen Level Dependent (BOLD cardiovascular magnetic resonance (CMR to detect stress-inducible myocardial ischemic reactions in the presence of angiographically significant coronary artery disease (CAD. Methods Forty-six patients (34 men; age 65 ± 9 years, with suspected or known coronary artery disease underwent CMR at 3Tesla prior to clinically indicated invasive coronary angiography. BOLD CMR was performed in 3 short axis slices of the heart at rest and during adenosine stress (140 μg/kg/min followed by late gadolinium enhancement (LGE imaging. In all 16 standard myocardial segments, T2* values were derived at rest and under adenosine stress. Quantitative coronary angiography served as the standard of reference and defined normal myocardial segments (i.e. all 16 segments in patients without any CAD, ischemic segments (i.e. supplied by a coronary artery with ≥50% luminal narrowing and non-ischemic segments (i.e. supplied by a non-significantly stenosed coronary artery in patients with significant CAD. Results Coronary angiography demonstrated significant CAD in 23 patients. BOLD CMR at rest revealed significantly lower T2* values for ischemic segments (26.7 ± 11.6 ms compared to normal (31.9 ± 11.9 ms; p Conclusions Rest and stress BOLD CMR at 3Tesla proved feasible and differentiated between ischemic, non-ischemic, and normal myocardial segments in a clinical patient population. BOLD CMR during vasodilator stress identified patients with significant CAD.

  10. Innovative Magnetic Resonance Imaging Markers of Hereditary Cerebral Amyloid Angiopathy at 7 Tesla.

    Science.gov (United States)

    Koemans, Emma A; van Etten, Ellis S; van Opstal, Anna M; Labadie, Gerda; Terwindt, Gisela M; Wermer, Marieke J H; Webb, Andrew G; Gurol, Edip M; Greenberg, Steven M; van Buchem, Mark A; van der Grond, Jeroen; van Rooden, Sanneke

    2018-06-01

    The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain changes can be observed in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) patients as compared with the established magnetic resonance imaging features of sporadic cerebral amyloid angiopathy. The local institutional review board approved this prospective cohort study. In all cases, informed consent was obtained. This prospective parallel cohort study was conducted between 2012 and 2014. We performed T 2 *-weighted magnetic resonance imaging performed at 7 Tesla in presymptomatic mutation carriers (n=11, mean age 35±12 years), symptomatic HCHWA-D patients (n=15, mean age 45±14 years), and in control subjects (n=29, mean age 45±14 years). Images were analyzed for the presence of changes that have not been reported before in sporadic cerebral amyloid angiopathy and HCHWA-D. Innovative observations comprised intragyral hemorrhaging and cortical changes. The presence of these changes was systematically assessed in all participants of the study. Symptomatic HCHWA-D-patients had a higher incidence of intragyral hemorrhage (47% [7/15], controls 0% [0/29], P <0.001), and a higher incidence of specific cortical changes (40% [6/15] versus 0% [0/29], P <0.005). In presymptomatic HCHWA-D-mutation carriers, the prevalence of none of these markers was increased compared with control subjects. The presence of cortical changes and intragyral hemorrhage are imaging features of HCHWA-D that may help recognizing sporadic cerebral amyloid angiopathy in living patients. © 2018 American Heart Association, Inc.

  11. Knee implant imaging at 3 Tesla using high-bandwidth radiofrequency pulses.

    Science.gov (United States)

    Bachschmidt, Theresa J; Sutter, Reto; Jakob, Peter M; Pfirrmann, Christian W A; Nittka, Mathias

    2015-06-01

    To investigate the impact of high-bandwidth radiofrequency (RF) pulses used in turbo spin echo (TSE) sequences or combined with slice encoding for metal artifact correction (SEMAC) on artifact reduction at 3 Tesla in the knee in the presence of metal. Local transmit/receive coils feature increased maximum B1 amplitude, reduced SAR exposition and thus enable the application of high-bandwidth RF pulses. Susceptibility-induced through-plane distortion scales inversely with the RF bandwidth and the view angle, hence blurring, increases for higher RF bandwidths, when SEMAC is used. These effects were assessed for a phantom containing a total knee arthroplasty. TSE and SEMAC sequences with conventional and high RF bandwidths and different contrasts were tested on eight patients with different types of implants. To realize scan times of 7 to 9 min, SEMAC was always applied with eight slice-encoding steps and distortion was rated by two radiologists. A local transmit/receive knee coil enables the use of an RF bandwidth of 4 kHz compared with 850 Hz in conventional sequences. Phantom scans confirm the relation of RF bandwidth and through-plane distortion, which can be reduced up to 79%, and demonstrate the increased blurring for high-bandwidth RF pulses. In average, artifacts in this RF mode are rated hardly visible for patients with joint arthroplasties, when eight SEMAC slice-encoding steps are applied, and for patients with titanium fixtures, when TSE is used. The application of high-bandwidth RF pulses by local transmit coils substantially reduces through-plane distortion artifacts at 3 Tesla. © 2014 Wiley Periodicals, Inc.

  12. High-resolution MRI of the wrist and finger joints in patients with rheumatoid arthritis: comparison of 1.5 Tesla and 3.0 Tesla

    International Nuclear Information System (INIS)

    Wieners, Gero; Detert, Jacqueline; Burmester, Gerd; Backhaus, Marina; Streitparth, Florian; Fischbach, Frank; Bruhn, Harald; Pech, Maciej; Ricke, Jens

    2007-01-01

    The goal of this study was to compare magnetic resonance (MR) image quality at different field strengths for evaluating lesions in wrist and finger joints of patients with rheumatoid arthritis (RA) in order to determine whether the higher field strength provides diagnostic gain. The hand mainly affected in 17 RA patients was examined at 1.5 Tesla (T) and 3.0 T with comparable MR imaging (MRI) protocols. MR images were reviewed twice by two experienced radiologists using the Rheumatoid Arthritis MRI Scoring System (RAMRIS) of the OMERACT (Outcome Measures in Rheumatoid Arthritis Clinical Trials) group. Image quality was rated on a five-point scale using Friedmann's test and Kendall's W-test for statistical analysis. Image comparison revealed better image quality at higher field strength. Image quality of T1-weighted images was rated 14-22% better at 3.0 T compared with 1.5 T by both readers. Moreover, the rating for the T2-weighted-images acquired at 3.0 T was one point better in the five-point scale used. Inter-reader correlation for image quality, bone erosions/defects, edema and synovitis ranged between 0.6 and 0.9 at 3.0 T and between 0.6 and 0.8 at 1.5 T. Intra-reader correlation for these parameters was high at 0.8-1.0. MRI image quality of RA hands is superior at 3.0 T, while an acceptable image quality is achieved at 1.5 T, which improves the evaluation of extent of bone edema, synovitis and identification of small bone erosions. (orig.)

  13. MR imaging of the ankle at 3 Tesla and 1.5 Tesla: protocol optimization and application to cartilage, ligament and tendon pathology in cadaver specimens

    International Nuclear Information System (INIS)

    Barr, Cameron; Malfair, David; Henning, Tobias D.; Steinbach, Lynne; Link, Thomas M.; Bauer, Jan S.; Ma, Benjamin

    2007-01-01

    The objective of this study was to optimize ankle joint MR imaging in volunteers at 1.5 Tesla (T) and 3.0 T, and to compare these optimized sequences concerning image quality and performance in assessing cartilage, ligament and tendon pathology in fresh human cadaver specimens. Initially our clinical ankle protocol consisting of T1-weighted (-w), fat-saturated (fs) T2-w, and short τ inversion-recovery fast spinecho (FSE) sequences was optimized at 1.5 T and 3.0 T by two radiologists. For dedicated cartilage imaging, fs-intermediate (IM)-w FSE, fs spoiled gradient echo, and balanced free-precession steady-state sequences were optimized. Using the optimized sequences, thirteen cadaver ankle joints were imaged. Four radiologists independently assessed these images concerning image quality and pathology. All radiologists consistently rated image quality higher at 3.0 T (all sequences p<0.05). For detecting cartilage pathology, diagnostic performance was significantly higher at 3.0 T (ROC-values up to 0.93 vs. 0.77; p<0.05); the fs-IM FSE sequence showed highest values among the different sequences. Average sensitivity for detecting tendon pathology was 63% at 3.0 T vs. 41% at 1.5 T and was significantly higher at 3.0 T for 2 out of 4 radiologists (p<0.05). Compared to 1.5 T, imaging of the ankle joint at 3.0 T significantly improved image quality and diagnostic performance in assessing cartilage pathology. (orig.)

  14. Molecular characterization of dissolved organic matter from subtropical wetlands: a comparative study through the analysis of optical properties, NMR and FTICR/MS

    Science.gov (United States)

    Hertkorn, Norbert; Harir, Mourad; Cawley, Kaelin M.; Schmitt-Kopplin, Philippe; Jaffé, Rudolf

    2016-04-01

    Wetlands provide quintessential ecosystem services such as maintenance of water quality, water supply and biodiversity, among others; however, wetlands are also among the most threatened ecosystems worldwide. Natural dissolved organic matter (DOM) is an abundant and critical component in wetland biogeochemistry. This study describes the first detailed, comparative, molecular characterization of DOM in subtropical, pulsed, wetlands, namely the Everglades (USA), the Pantanal (Brazil) and the Okavango Delta (Botswana), using optical properties, high-field nuclear magnetic resonance (NMR) and ultrahigh-resolution mass spectrometry (FT-ICRMS), and compares compositional features to variations in organic matter sources and flooding characteristics (i.e., differences in hydroperiod). While optical properties showed a high degree of variability within and between the three wetlands, analogies in DOM fluorescence properties were such that an established excitation emission matrix fluorescence parallel factor analysis (EEM-PARAFAC) model for the Everglades was perfectly applicable to the other two wetlands. Area-normalized 1H NMR spectra of selected samples revealed clear distinctions of samples while a pronounced congruence within the three pairs of wetland DOM readily suggested the presence of an individual wetland-specific molecular signature. Within sample pairs (long- vs. short-hydroperiod sites), internal differences mainly referred to intensity variations (denoting variable abundance) rather than to alterations of NMR resonances positioning (denoting diversity of molecules). The relative disparity was largest between the Everglades long- and short-hydroperiod samples, whereas Pantanal and Okavango samples were more alike among themselves. Otherwise, molecular divergence was most obvious in the case of unsaturated protons (δH > 5 ppm). 2-D NMR spectroscopy for a particular sample revealed a large richness of aliphatic and unsaturated substructures, likely derived from

  15. Rectal cancer confined to the bowel wall: the role of 3 Tesla phased-array MR imaging in T categorization.

    Science.gov (United States)

    Çolakoğlu Er, Hale; Peker, Elif; Erden, Ayşe; Erden, İlhan; Geçim, Ethem; Savaş, Berna

    2018-02-01

    To determine the diagnostic value of 3 Tesla MR imaging in detection of mucosal (Tis), submucosal (T 1 ) and muscularis propria (T 2 ) invasion in patients with early rectal cancer. A total of 50 consecutive patients who underwent 3 Tesla MR imaging and curative-intent intervention for MRI-staged Tis/T 1 /T 2 rectal cancer from March 2012 to December 2016 were included. The radiological T category of each rectal tumour was compared retrospectively with histopathological results assessed according to the tumor, node, metastasis (TNM) classification. The sensitivities, specificities, and overall accuracy rates of 3 Tesla MR imaging for Tis, T 1 , and T 2 cases were calculated using MedCalc statistical software v. 16. The sensitivity, specificity, PPV, NPV of 3 Tesla MR imaging in T categorization for T 2 were: 93.7% [95% CI (0.79-0.99)], 77.7% [95% CI (0.52-0.93)], 88.2% [95% CI (0.75-0.94)] and 87.5% [95% CI (0.64-0.96)]; for T 1 were 92% [95% CI (0.63-0.99)], 91.8% [95% CI (0.78-0.98)], 80% [95% CI (0.57-0.92)] and 97.1% [95% CI (0.83-0.99)]; for Tis were: 20% [95% CI (0.51-0.71)], 100% [95% CI (0.92-1)], 100%, 91.8% [95% CI (0.87-0.94)], respectively. MR categorization accuracy rates for T 2 , T 1 and Tis were calculated as 88, 92 and 92%, respectively. 3 Tesla MR imaging seems to be useful for accurate categorization of T-stage in early rectal cancer, especially for T 1 cancers. The method is not a reliable tool to detect Tis cases. The potential for overstaging and understaging of the technique should be realized and taken into consideration when tailoring the treatment protocol for each patient. Advances in knowledge: High-resolution MR with phased-array coil is being increasingly used in the pre-operative assessment of rectal cancer. 3 Tesla high-resolution MR imaging allows improved definition of bowel wall and tumour infiltration.

  16. Multicontrast-weighted magnetic resonance imaging of atherosclerotic plaques at 3.0 and 1.5 Tesla: ex-vivo comparison with histopathologic correlation

    International Nuclear Information System (INIS)

    Koops, Andreas; Ittrich, Harald; Priest, Andrew; Stork, Alexander; Adam, Gerhard; Weber, Christoph; Petri, Susan; Lockemann, Ute

    2007-01-01

    The purpose was to analyze magnetic resonance (MR) plaque imaging at 3.0 Tesla and 1.5 Tesla in correlation with histopathology. MR imaging (MRI) of the abdominal aorta and femoral artery was performed on seven corpses using T1-weighted, T2-weighted, and PD-weighted sequences at 3.0 and 1.5 Tesla. Cross-sectional images at the branching of the inferior mesenteric artery and the profunda femoris were rated with respect to image quality. Corresponding cross sections of the imaged vessels were obtained at autopsy. The atherosclerotic plaques in the histological slides and MR images were classified according to the American Heart Association (AHA) and analyzed for differences. MRI at 3.0 Tesla offered superior depiction of arterial wall composition in all contrast weightings, rated best for T2-weighted images. Comparing for field strength, the highest differences were observed in T1-weighted and T2-weighted techniques (both P≤0.001), with still significant differences in PD-weighted sequence (P≤0.005). The majority of plaques were histologically classified as calcified plaques. In up to 21% of the cases, MRI at both field strengths detected signal loss characteristic of calcification although calcified plaque was absent in histology. MRI at 3.0 Tesla offers superior plaque imaging quality compared with 1.5 Tesla, but further work is necessary to determine whether this translates in superior diagnostic accuracy. (orig.)

  17. Multidirectional pseudodynamic studies of the bilateral temporomandibular joint diseases with 0.2-Tesla MR imaging unit

    International Nuclear Information System (INIS)

    Sasaki, Makoto; Ehara, Shigeru; Nakasato, Tatsuhiko; Tamakawa, Yoshiharu; Sugisawa, Miyoshi; Iwahana, Hideaki; Kuboya, Yasuo.

    1996-01-01

    Sagittal and coronal images of the bilateral temporomandibular joint (TMJ) simultaneously have been obtained to evaluate displacement of the meniscus in nine patients with TMJ clicking using a 0.2-Tesla permanent magnetic unit. The obtained images were displayed in closed loop cine fashion and recorded on videotapes. Anterior displacement of meniscus was seen on sagittal images in 5 of 9 paients. In the other four patients, no anterior displacement was observed, but in three of them, medial and lateral displacement on coronal images were shown in the closed position. Even using the 0.2-Tesla unit, simultaneous pseudodynamic display of the bilateral TMJ in sagittal and coronal planes was useful for evaluating internal derangement of the TMJ. This technique not only saves time but provides accurate evaluation of meniscal position and motion. (H.O.)

  18. In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla

    OpenAIRE

    Alomair, Othman I.; Brereton, Ian M.; Smith, Maree T.; Galloway, Graham J.; Kurniawan, Nyoman D.

    2015-01-01

    Magnetic Resonance Imaging (MRI) of the rodent brain at ultra-high magnetic fields (> 9.4 Tesla) offers a higher signal-to-noise ratio that can be exploited to reduce image acquisition time or provide higher spatial resolution. However, significant challenges are presented due to a combination of longer T 1 and shorter T 2/T2* relaxation times and increased sensitivity to magnetic susceptibility resulting in severe local-field inhomogeneity artefacts from air pockets and bone/brain interfaces...

  19. PLACD-7T Study: Atherosclerotic Carotid Plaque Components Correlated with Cerebral Damage at 7 Tesla Magnetic Resonance Imaging

    Science.gov (United States)

    den Hartog, A.G; Bovens, S.M; Koning, W; Hendrikse, J; Pasterkamp, G; Moll, F.L; de Borst, G.J

    2011-01-01

    Introduction: In patients with carotid artery stenosis histological plaque composition is associated with plaque stability and with presenting symptomatology. Preferentially, plaque vulnerability should be taken into account in pre-operative work-up of patients with severe carotid artery stenosis. However, currently no appropriate and conclusive (non-) invasive technique to differentiate between the high and low risk carotid artery plaque in vivo is available. We propose that 7 Tesla human high resolution MRI scanning will visualize carotid plaque characteristics more precisely and will enable correlation of these specific components with cerebral damage. Study objective: The aim of the PlaCD-7T study is 1: to correlate 7T imaging with carotid plaque histology (gold standard); and 2: to correlate plaque characteristics with cerebral damage ((clinically silent) cerebral (micro) infarcts or bleeds) on 7 Tesla high resolution (HR) MRI. Design: We propose a single center prospective study for either symptomatic or asymptomatic patients with haemodynamic significant (70%) stenosis of at least one of the carotid arteries. The Athero-Express (AE) biobank histological analysis will be derived according to standard protocol. Patients included in the AE and our prospective study will undergo a pre-operative 7 Tesla HR-MRI scan of both the head and neck area. Discussion: We hypothesize that the 7 Tesla MRI scanner will allow early identification of high risk carotid plaques being associated with micro infarcted cerebral areas, and will thus be able to identify patients with a high risk of periprocedural stroke, by identification of surrogate measures of increased cardiovascular risk. PMID:22294972

  20. In vitro assessment of MRI issues at 3-Tesla for a breast tissue expander with a remote port.

    Science.gov (United States)

    Linnemeyer, Hannah; Shellock, Frank G; Ahn, Christina Y

    2014-04-01

    A patient with a breast tissue expander may require a diagnostic assessment using magnetic resonance imaging (MRI). To ensure patient safety, this type of implant must undergo in vitro MRI testing using proper techniques. Therefore, this investigation evaluated MRI issues (i.e., magnetic field interactions, heating, and artifacts) at 3-Tesla for a breast tissue expander with a remote port. A breast tissue expander with a remote port (Integra Breast Tissue Expander, Model 3612-06 with Standard Remote Port, PMT Corporation, Chanhassen, MN) underwent evaluation for magnetic field interactions (translational attraction and torque), MRI-related heating, and artifacts using standardized techniques. Heating was evaluated by placing the implant in a gelled-saline-filled phantom and MRI was performed using a transmit/receive RF body coil at an MR system reported, whole body averaged specific absorption rate of 2.9-W/kg. Artifacts were characterized using T1-weighted and GRE pulse sequences. Magnetic field interactions were not substantial and, thus, will not pose a hazard to a patient in a 3-Tesla or less MRI environment. The highest temperature rise was 1.7°C, which is physiologically inconsequential. Artifacts were large in relation to the remote port and metal connector of the implant but will only present problems if the MR imaging area of interest is where these components are located. A patient with this breast tissue expander with a remote port may safely undergo MRI at 3-Tesla or less under the conditions used for this investigation. These findings are the first reported at 3-Tesla for a tissue expander. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Magnetic resonance imaging investigation of the bone conduction implant – a pilot study at 1.5 Tesla

    Science.gov (United States)

    Jansson, Karl-Johan Fredén; Håkansson, Bo; Reinfeldt, Sabine; Rigato, Cristina; Eeg-Olofsson, Måns

    2015-01-01

    Purpose The objective of this pilot study was to investigate if an active bone conduction implant (BCI) used in an ongoing clinical study withstands magnetic resonance imaging (MRI) of 1.5 Tesla. In particular, the MRI effects on maximum power output (MPO), total harmonic distortion (THD), and demagnetization were investigated. Implant activation and image artifacts were also evaluated. Methods and materials One implant was placed on the head of a test person at the position corresponding to the normal position of an implanted BCI and applied with a static pressure using a bandage and scanned in a 1.5 Tesla MRI camera. Scanning was performed both with and without the implant, in three orthogonal planes, and for one spin-echo and one gradient-echo pulse sequence. Implant functionality was verified in-between the scans using an audio processor programmed to generate a sequence of tones when attached to the implant. Objective verification was also carried out by measuring MPO and THD on a skull simulator as well as retention force, before and after MRI. Results It was found that the exposure of 1.5 Tesla MRI only had a minor effect on the MPO, ie, it decreased over all frequencies with an average of 1.1±2.1 dB. The THD remained unchanged above 300 Hz and was increased only at lower frequencies. The retention magnet was demagnetized by 5%. The maximum image artifacts reached a distance of 9 and 10 cm from the implant in the coronal plane for the spin-echo and the gradient-echo sequence, respectively. The test person reported no MRI induced sound from the implant. Conclusion This pilot study indicates that the present BCI may withstand 1.5 Tesla MRI with only minor effects on its performance. No MRI induced sound was reported, but the head image was highly distorted near the implant. PMID:26604836

  2. Ventricular Assist Device implant (AB 5000 prototype cannula: In vitro assessment of MRI issues at 3-Tesla

    Directory of Open Access Journals (Sweden)

    Valencerina Samuel

    2008-05-01

    Full Text Available Abstract Purpose To evaluate MRI issues at 3-Tesla for a ventricular assist device (VAD. Methods The AB5000 Ventricle with a prototype Nitinol wire-reinforced In-Flow Cannula and Out-Flow Cannula attached (Abiomed, Inc., Danvers, MA was evaluated for magnetic field interactions, heating, and artifacts at 3-Tesla. MRI-related heating was assessed with the device in a gelled-saline-filled, head/torso phantom using a transmit/received RF body coil while performing MRI at a whole body averaged SAR of 3-W/kg for 15-min. Artifacts were assessed for the main metallic component of this VAD (atrial cannula using T1-weighted, spin echo and gradient echo pulse sequences. Results The AB5000 Ventricle with the prototype In-Flow Cannula and Out-Flow Cannula attached showed relatively minor magnetic field interactions that will not cause movement in situ. Heating was not excessive (highest temperature change, +0.8°C. Artifacts may create issues for diagnostic imaging if the area of interest is in the same area or close to the implanted metallic component of this VAD (i.e., the venous cannula. Conclusion The results of this investigation demonstrated that it would be acceptable for a patient with this VAD (AB5000 Ventricle with a prototype Nitinol wire-reinforced In-Flow Cannula and Out-Flow Cannula attached to undergo MRI at 3-Tesla or less. Notably, it is likely that the operation console for this device requires positioning a suitable distance (beyond the 100 Gauss line or in the MR control room from the 3-Tesla MR system to ensure proper function of the VAD.

  3. Magnetic resonance imaging investigation of the bone conduction implant - a pilot study at 1.5 Tesla.

    Science.gov (United States)

    Jansson, Karl-Johan Fredén; Håkansson, Bo; Reinfeldt, Sabine; Rigato, Cristina; Eeg-Olofsson, Måns

    2015-01-01

    The objective of this pilot study was to investigate if an active bone conduction implant (BCI) used in an ongoing clinical study withstands magnetic resonance imaging (MRI) of 1.5 Tesla. In particular, the MRI effects on maximum power output (MPO), total harmonic distortion (THD), and demagnetization were investigated. Implant activation and image artifacts were also evaluated. One implant was placed on the head of a test person at the position corresponding to the normal position of an implanted BCI and applied with a static pressure using a bandage and scanned in a 1.5 Tesla MRI camera. Scanning was performed both with and without the implant, in three orthogonal planes, and for one spin-echo and one gradient-echo pulse sequence. Implant functionality was verified in-between the scans using an audio processor programmed to generate a sequence of tones when attached to the implant. Objective verification was also carried out by measuring MPO and THD on a skull simulator as well as retention force, before and after MRI. It was found that the exposure of 1.5 Tesla MRI only had a minor effect on the MPO, ie, it decreased over all frequencies with an average of 1.1±2.1 dB. The THD remained unchanged above 300 Hz and was increased only at lower frequencies. The retention magnet was demagnetized by 5%. The maximum image artifacts reached a distance of 9 and 10 cm from the implant in the coronal plane for the spin-echo and the gradient-echo sequence, respectively. The test person reported no MRI induced sound from the implant. This pilot study indicates that the present BCI may withstand 1.5 Tesla MRI with only minor effects on its performance. No MRI induced sound was reported, but the head image was highly distorted near the implant.

  4. A review on the mass spectrometric studies of americium: Present status and future perspective.

    Science.gov (United States)

    Aggarwal, Suresh Kumar

    2018-01-01

    The manuscript reviews the various mass spectrometric techniques for analysis and chemical studies of Americium. These methods include thermal ionization mass spectrometry (TIMS), and inductively coupled plasma source mass spectrometry (ICPMS) for the determination of Am isotope ratios and concentration in nuclear fuel samples of interest in nuclear technology, and in complex biological and environmental samples. Ultra-sensitive mass spectrometric techniques of resonance-ionization mass spectrometry (RIMS), and accelerator-based mass spectrometry (AMS) are also discussed. The novel applications of electrospray ionization mass spectrometry (ESIMS) to understand the solution chemistry of Am and other actinides are presented. These studies are important in view of the world-wide efforts to develop novel complexing agents to separate lanthanides and minor actinides (Am, Np, and Cm) for partitioning and transmutation of minor actinides from the point of view of nuclear waste management. These mass spectrometry experiments are also of great interest to examine the covalent character of actinides with increasing atomic number. Studies on gas-phase chemistry of Am and its oxides with Knudsen effusion mass spectrometry (KEMS), Fourier-transform ion cyclotron resonance mass spectrometry (FTICR-MS), and laser-based experiments with reflectron time-of-flight mass spectrometer (R-ToF) are highlighted. These studies are important to understand the fundamental chemistry of 5f electrons in actinides. Requirement of certified isotopic reference materials of Am to improve the accuracy of experimental nuclear data (e.g., the half-life of 243 Am) is emphasized. © 2016 Wiley Periodicals, Inc. Mass Spec Rev. © 2016 Wiley Periodicals, Inc.

  5. MR imaging at 0.5 Tesla with FLAIR sequence in the diagnosis of acute subarachnoid hemorrhage

    International Nuclear Information System (INIS)

    Kopsa, W.; Leitner, H.; Tscholakoff, D.; Perneczky, G.

    1998-01-01

    Purpose: Evaluation of MR imaging in patients with acute subarachnoid hemorrhage (SAH) at 0.5 Tesla using the FLAIR (Fluid Attenuated Inversion Recovery) sequenze. Additionally, the value of MR angiographie (MRA) in the diagnosis of intracranial aneurysms was assessed. Materials and Methods: 19 patients with suspected acute SAH were included in this study. MR imaging was performed using an axial FLAIR sequence and axial T 1 , T 2 and PD weighted sequences. In 16 patients an additional MRA (3D-TOF) was performed. 10 patients without SAH were examined as a control group. At the end of the study the 29 MR examinations were randomised and the images were read by two experienced radiologists; subsequently a consensus interpretation was made. Results: In 16 patients an acute SAH was verified with the FLAIR sequence, in 13 cases the origin of hemorrhage was found during surgery. In the consensus interpretation of the MR images all cases were diagnosed properly. 12 of the 16 MRA studies were of diagnostic quality, but only 6 cases were interpreted correctly. Conclusion: The FLAIR sequence at 0.5 Tesla proved effective in the diagnosis of acute SAH. MRA at 0.5 Tesla failed in the detection of intracranial aneurysms. (orig.) [de

  6. Pulsatility of Lenticulostriate Arteries Assessed by 7 Tesla Flow MRI-Measurement, Reproducibility, and Applicability to Aging Effect.

    Science.gov (United States)

    Schnerr, Roald S; Jansen, Jacobus F A; Uludag, Kamil; Hofman, Paul A M; Wildberger, Joachim E; van Oostenbrugge, Robert J; Backes, Walter H

    2017-01-01

    Characterization of flow properties in cerebral arteries with 1.5 and 3 Tesla MRI is usually limited to large cerebral arteries and difficult to evaluate in the small perforating arteries due to insufficient spatial resolution. In this study, we assessed the feasibility to measure blood flow waveforms in the small lenticulostriate arteries with 7 Tesla velocity-sensitive MRI. The middle cerebral artery was included as reference. Imaging was performed in five young and five old healthy volunteers. Flow was calculated by integrating time-varying velocity values over the vascular cross-section. MRI acquisitions were performed twice in each subject to determine reproducibility. From the flow waveforms, the pulsatility index and damping factor were deduced. Reproducibility values, in terms of the intraclass correlation coefficients, were found to be good to excellent. Measured pulsatility index of the lenticulostriate arteries significantly increased and damping factor significantly decreased with age. In conclusion, we demonstrate that blood flow through the lenticostriate arteries can be precisely measured using 7 Tesla MRI and reveal effects of arterial stiffness due to aging. These findings hold promise to provide relevant insights into the pathologies involving perforating cerebral arteries.

  7. Interference with cardiac pacemakers by magnetic resonance imaging: are there irreversible changes at 0.5 Tesla?

    Science.gov (United States)

    Vahlhaus, C; Sommer, T; Lewalter, T; Schimpf, R; Schumacher, B; Jung, W; Lüderitz, B

    2001-04-01

    The safety and feasibility of magnetic resonance imaging (MRI) in patients with cardiac pacemakers is an issue of gaining significance. The effect of MRI on patients' pacemaker systems has only been analyzed retrospectively in some case reports. Therefore, this study prospectively investigated if MRI causes irreversible changes in patients' pacemaker systems. The effect of MRI at 0.5 Tesla on sensing and stimulation thresholds, lead impedance and battery voltage, current, and impedance was estimated during 34 MRI examinations in 32 patients with implanted pacemakers. After measurements at baseline and with documentation of intrinsic rhythm and modification of the pacing mode, patients underwent MRI. The rest of the function time of the pacemaker was calculated. Measurements were again performed after 99.5 +/- 29.6 minutes (mean +/- SD), immediately after MRI examination, and 3 months later. Lead impedance and sensing and stimulation thresholds did not change after MRI. Battery voltage decreased immediately after MRI and recovered 3 months later. Battery current and impedance tended to increase. The calculated rest of function time did not change immediately after MRI. MRI affected neither pacemaker programmed data, nor the ability to interrogate, program, or use telemetry. Surprisingly, in the gantry of the scanner, temporary deactivation of the reed switch occurred in 12 of 32 patients when positioned in the center of the magnetic field. Missing activation of the reed switch through the static magnetic field at 0.5 Tesla is not unusual. MRI at 0.5 Tesla does not cause irreversible changes in patients' pacemaker systems.

  8. 3.0 Tesla breast magnetic resonance imaging in patients with nipple discharge when mammography and ultrasound fail

    Energy Technology Data Exchange (ETDEWEB)

    Lubina, Nora; Schedelbeck, Ulla; Weng, Andreas Max; Hahn, Dietbert; Bley, Thorsten Alexander [University of Wuerzburg, Department of Diagnostic and Interventional Radiology, Wuerzburg (Germany); Roth, Anne [Centre of Radiology Wuerzburg, Wuerzburg (Germany); Geissinger, Eva [University of Wuerzburg, Institute of Pathology, Wuerzburg (Germany); Hoenig, Arnd [Catholic Clinical Centre Mainz, Department of Obstetrics and Gynecology, Mainz (Germany)

    2015-05-01

    To compare 3.0 Tesla breast magnetic resonance imaging (MRI) with galactography for detection of benign and malignant causes of nipple discharge in patients with negative mammography and ultrasound. We prospectively evaluated 56 breasts of 50 consecutive patients with nipple discharge who had inconspicuous mammography and ultrasound, using 3.0 Tesla breast MRI with a dedicated 16-channel breast coil, and then compared the results with galactography. Histopathological diagnoses and follow-ups were used as reference standard. Lesion size estimated on MRI was compared with the size at histopathology. Sensitivity and specificity of MRI vs. galactography for detecting pathologic findings were 95.7 % vs. 85.7 % and 69.7 % vs. 33.3 %, respectively. For the supposed concrete pathology based on MRI findings, the specificity was 67.6 % and the sensitivity 77.3 % (PPV 60.7 %, NPV 82.1 %). Eight malignant lesions were detected (14.8 %). The estimated size at breast MRI showed excellent correlation with the size at histopathology (Pearson's correlation coefficient 0.95, p < 0.0001). MRI of the breast at 3.0 Tesla is an accurate imaging test and can replace galactography in the workup of nipple discharge in patients with inconspicuous mammography and ultrasound. (orig.)

  9. Is the Ellipsoid Formula the New Standard for 3-Tesla MRI Prostate Volume Calculation without Endorectal Coil?

    Science.gov (United States)

    Haas, Matthias; Günzel, Karsten; Miller, Kurt; Hamm, Bernd; Cash, Hannes; Asbach, Patrick

    2017-01-01

    Prostate volume in multiparametric MRI (mpMRI) is of clinical importance. For 3-Tesla mpMRI without endorectal coil, there is no distinctive standard for volume calculation. We tested the accuracy of the ellipsoid formula with planimetric volume measurements as reference and investigated the correlation of gland volume and cancer detection rate on MRI/ultrasound (MRI/US) fusion-guided biopsy. One hundred forty-three patients with findings on 3-Tesla mpMRI suspicious of cancer and subsequent MRI/US fusion-guided targeted biopsy and additional systematic biopsy were analyzed. T2-weighted images were used for measuring the prostate diameters and for planimetric volume measurement by a segmentation software. Planimetric and calculated prostate volumes were compared with clinical data. The median prostate volume was 48.1 ml (interquartile range (IQR) 36.9-62.1 ml). Volume calculated by the ellipsoid formula showed a strong concordance with planimetric volume, with a tendency to underestimate prostate volume (median volume 43.1 ml (IQR 31.2-58.8 ml); r = 0.903, p Tesla mpMRI without endorectal coil. It allows a fast, valid volume calculation in prostate MRI datasets. © 2016 S. Karger AG, Basel.

  10. 3.0 Tesla breast magnetic resonance imaging in patients with nipple discharge when mammography and ultrasound fail.

    Science.gov (United States)

    Lubina, Nóra; Schedelbeck, Ulla; Roth, Anne; Weng, Andreas Max; Geissinger, Eva; Hönig, Arnd; Hahn, Dietbert; Bley, Thorsten Alexander

    2015-05-01

    To compare 3.0 Tesla breast magnetic resonance imaging (MRI) with galactography for detection of benign and malignant causes of nipple discharge in patients with negative mammography and ultrasound. We prospectively evaluated 56 breasts of 50 consecutive patients with nipple discharge who had inconspicuous mammography and ultrasound, using 3.0 Tesla breast MRI with a dedicated 16-channel breast coil, and then compared the results with galactography. Histopathological diagnoses and follow-ups were used as reference standard. Lesion size estimated on MRI was compared with the size at histopathology. Sensitivity and specificity of MRI vs. galactography for detecting pathologic findings were 95.7 % vs. 85.7 % and 69.7 % vs. 33.3 %, respectively. For the supposed concrete pathology based on MRI findings, the specificity was 67.6 % and the sensitivity 77.3 % (PPV 60.7 %, NPV 82.1 %). Eight malignant lesions were detected (14.8 %). The estimated size at breast MRI showed excellent correlation with the size at histopathology (Pearson's correlation coefficient 0.95, p 3.0 Tesla is an accurate imaging test and can replace galactography in the workup of nipple discharge in patients with inconspicuous mammography and ultrasound. • Breast MRI is an excellent diagnostic tool for patients with nipple discharge. • MRI of the breast reveals malignant lesions despite inconspicuous mammography and ultrasound. • MRI of the breast has greater sensitivity and specificity than galactography. • Excellent correlation of lesion size measured at MRI and histopathology was found.

  11. Breath-hold imaging of the coronary arteries using Quiescent-Interval Slice-Selective (QISS) magnetic resonance angiography: pilot study at 1.5 Tesla and 3 Tesla.

    Science.gov (United States)

    Edelman, Robert R; Giri, S; Pursnani, A; Botelho, M P F; Li, W; Koktzoglou, I

    2015-11-23

    Coronary magnetic resonance angiography (MRA) is usually obtained with a free-breathing navigator-gated 3D acquisition. Our aim was to develop an alternative breath-hold approach that would allow the coronary arteries to be evaluated in a much shorter time and without risk of degradation by respiratory motion artifacts. For this purpose, we implemented a breath-hold, non-contrast-enhanced, quiescent-interval slice-selective (QISS) 2D technique. Sequence performance was compared at 1.5 and 3 Tesla using both radial and Cartesian k-space trajectories. The left coronary circulation was imaged in six healthy subjects and two patients with coronary artery disease. Breath-hold QISS was compared with T2-prepared 2D balanced steady-state free-precession (bSSFP) and free-breathing, navigator-gated 3D bSSFP. Approximately 10 2.1-mm thick slices were acquired in a single ~20-s breath-hold using two-shot QISS. QISS contrast-to-noise ratio (CNR) was 1.5-fold higher at 3 Tesla than at 1.5 Tesla. Cartesian QISS provided the best coronary-to-myocardium CNR, whereas radial QISS provided the sharpest coronary images. QISS image quality exceeded that of free-breathing 3D coronary MRA with few artifacts at either field strength. Compared with T2-prepared 2D bSSFP, multi-slice capability was not restricted by the specific absorption rate at 3 Tesla and pericardial fluid signal was better suppressed. In addition to depicting the coronary arteries, QISS could image intra-cardiac structures, pericardium, and the aortic root in arbitrary slice orientations. Breath-hold QISS is a simple, versatile, and time-efficient method for coronary MRA that provides excellent image quality at both 1.5 and 3 Tesla. Image quality exceeded that of free-breathing, navigator-gated 3D MRA in a much shorter scan time. QISS also allowed rapid multi-slice bright-blood, diastolic phase imaging of the heart, which may have complementary value to multi-phase cine imaging. We conclude that, with further clinical

  12. Effect of magnetic flux-densities of up to 0.1 Tesla on copper electrodeposition

    Directory of Open Access Journals (Sweden)

    Cifuentes, L.

    2003-08-01

    Full Text Available The effect of magnetic flux densities (B between 0.0 and 0.1 Tesla on cathode and anode overpotentials, cell voltage and electrodeposit quality was determined for a lab-scale copper electrowinning cell which operates at industrial current density values. Cell voltage decreases with increasing B. The cathodic overpotential decreases by 30 % when B increases from 0.0 to 0.1 T The anodic overpotential also decreases with increasing B, but this effect is six times less than the corresponding effect on the cathodic overpotential. Cathodic effects can be predicted by an expression derived from electrochemical kinetics and magnetohydrodynamic theory. Anodic effects cannot be predicted in the same way. The size of grains and intergranular voids decreases and the surface of the electrodeposit becomes smoother as B increases, which means that, in the studied conditions, the quality of the produced copper deposits improves.

    Se determinó el efecto de densidades de flujo magnético (B de, hasta 0,1 Tesla, sobre los sobrepotenciales catódico y anódico, la tensión de celda y la calidad del electrodepósito en una celda de electroobtención de cobre que opera a valores industriales de densidad de corriente. La tensión de celda decrece al aumentar B. El sobrepotencial catódico disminuye en 30 % cuando B aumenta de 0,0 a 0,1 T El sobrepotencial anódico también disminuye al crecer B, pero este efecto es seis veces menor que en el caso catódico. Los efectos catódicos pueden predecirse por medio de una expresión deducida de la cinética electroquímica y la magnetohidrodinámica. No es posible realizar una predicción análoga de los efectos anódicos. El tamaño de los granos y de los huecos intergranulares decrece y la superficie del electrodepósito se hace más pareja al aumentar B, lo que implica que, en las condiciones estudiadas, la calidad del depósito de cobre mejora.

  13. Chronic anal fissure: morphometric analysis of the anal canal at 3.0 Tesla MR imaging.

    Science.gov (United States)

    Erden, Ayşe; Peker, Elif; Gençtürk, Zeynep Bıyıklı

    2017-02-01

    OBJECTıVE: To compare the morphometric data relating to the muscular structures of the anal canal, in patients with chronic anal fissure and in control group, examined at a 3.0 Tesla MR system. Forty-seven consecutive patients with chronic anal fissure and randomly selected 40 patients who had no claims for perianal disease during their life time were included in the study. T2-weighted sagittal, high-resolution (HR) T2-weighted, and contrast-enhanced fat-suppressed T1-weighted oblique axial and oblique coronal images were retrospectively analyzed by two observers in consensus. Thickness of sphincteric muscles, anal canal length, anorectal angle, thickness of anococcygeal ligament, depth of Minor triangle, width between subcutaneous sphincters, vascularity of posterior commissure, visibility of posterosuperior projection of external sphincter, and angle between the distal anal canal and posterosuperior projection of external sphincter (H angle) in patients and in controls were compared and analyzed using t test, Mann-Whitney U test, and Spearman correlation. The patients with chronic anal fissure had longer anal canal (51.50 mm ± 0.91 vs. 44.11 mm ± 0.71; p = 0.000), thicker internal anal sphincter muscle at mid-anal level (4.18 ± 0.15 vs. 3.39 ± 0.07; p = 0.007), and wider space between subcutaneous external sphincters (11.39 ± 0.50 vs. 6.89 ± 0.22; p = 0.000). In patients, there was a positive correlation between H angle and external sphincter thickness at proximal (r = 0.347; p = 0.021), middle (r = 0427; p = 0.000), and distal (r = 0.518; p = 0.000)) levels of the anal canal. CONCLUSıON: 3.0 Tesla MR imaging provides detailed information about the morphometric changes in the anal sphincter muscles in patients with chronic anal fissure.

  14. Influence of the trigger technique on ventricular function measurements using 3-Tesla magnetic resonance imaging: comparison of ECG versus pulse wave triggering

    International Nuclear Information System (INIS)

    Sievers, Burkhard; Wiesner, Marco; Kiria, Nino; Speiser, Uwe; Schoen, Steffen; Strasser, Ruth H.

    2011-01-01

    Background Three Tesla cardiovascular magnetic resonance imaging (3T-CMR) is increasingly used in clinical practice. Despite many advantages one drawback is that ECG signal disturbances and artifacts increase with higher magnetic field strength resulting in trigger problems and false gating. This particularly affects cardiac imaging because most pulse sequences require ECG triggering. Pulse wave (PW) triggering is robust and might have advantages over ECG triggering. Purpose To evaluate differences in left ventricular (LV) function as an integral part of most CMR studies between ECG- and PW-triggered short-axis imaging using 3T-CMR. Material and Methods Forty-three patients underwent multiple short-axis cine imaging for LV-function assessment with ECG and PW triggering using standard multi breath hold steady-state free precession. LV-volumes (EDV, ESV), ejection fraction (EF), and mass were determined by slice summation. LV-wall motion was assessed by using a 4-point scoring scale. Bland Altman statistics for inter-observer variability were performed. Results ECG triggering failed in 15 patients (34.8%). Thus, analysis was performed in 28 patients (13 with impaired LV function). Difference in volumes (EDV 0.13 ± 1.8 mL, ESV 0.59 ± 1.1 mL), EF (-0.32 ± 0.6%) and mass (0.01 ± 1.1 g) between ECG and PW triggering were very small and significant only for ESV and EF (p 0.011). In patients with impaired LV function (n = 19) differences were not significant (p = 0.128). Wall motion scores did not differ between ECG and PW triggering (p = 0.295). Inter-observer variability for function measurements was low. Conclusion Short-axis cine imaging for LV-function assessment can accurately be performed using PW triggering on 3T magnets, and may be used in clinical practice when ECG triggering is disturbed

  15. Combination of liquid chromatography-Fourier transform ion cyclotron resonance-mass spectrometry with 13C-labeling for chemical assignment of sulfur-containing metabolites in onion bulbs.

    Science.gov (United States)

    Nakabayashi, Ryo; Sawada, Yuji; Yamada, Yutaka; Suzuki, Makoto; Hirai, Masami Yokota; Sakurai, Tetsuya; Saito, Kazuki

    2013-02-05

    Phytochemicals containing heteroatoms (N, O, S, and halogens) often have biological activities that are beneficial to humans. Although targeted profiling methods for such phytochemicals are expected to contribute to rapid chemical assignments, thus making phytochemical genomics and crop breeding much more efficient, there are few profiling methods for the metabolites. Here, as an ultrahigh performance approach, we propose a practical profiling method for S-containing metabolites (S-omics) using onions (Allium cepa) as a representative species and (12)C- and (13)C-based mass spectrometry (MS) and tandem mass spectrometry (MS/MS) analyses by liquid chromatography-Fourier transform ion cyclotron resonance-mass spectrometry (LC-FTICR-MS). Use of the ultrahigh quality data from FTICR-MS enabled simplifying the previous methods to determine specific elemental compositions. MS analysis with a resolution of >250,000 full width at half-maximum and a mass accuracy of ions from other ions on the basis of the natural abundance of (32)S and (34)S and the mass differences among the S isotopes. Comprehensive peak picking using the theoretical mass difference (1.99579 Da) between (32)S-containing monoisotopic ions and their (34)S-substituted counterparts led to the assignment of 67 S-containing monoisotopic ions from the (12)C-based MS spectra, which contained 4693 chromatographic ions. The unambiguous elemental composition of 22 ions was identified through comparative analysis of the (12)C- and (13)C-based MS spectra. Finally, of these, six ions were found to be derived from S-alk(en)ylcysteine sulfoxides and glutathione derivatives. This S-atom-driven approach afforded an efficient chemical assignment of S-containing metabolites, suggesting its potential application for screening not only S but also other heteroatom-containing metabolites in MS-based metabolomics.

  16. Single-row vs. double-row arthroscopic rotator cuff repair: clinical and 3 Tesla MR arthrography results

    Science.gov (United States)

    2013-01-01

    Background Arthroscopic rotator cuff repair has become popular in the last few years because it avoids large skin incisions and deltoid detachment and dysfunction. Earlier arthroscopic single-row (SR) repair methods achieved only partial restoration of the original footprint of the tendons of the rotator cuff, while double-row (DR) repair methods presented many biomechanical advantages and higher rates of tendon-to-bone healing. However, DR repair failed to demonstrate better clinical results than SR repair in clinical trials. MR imaging at 3 Tesla, especially with intra-articular contrast medium (MRA), showed a better diagnostic performance than 1.5 Tesla in the musculoskeletal setting. The objective of this study was to retrospectively evaluate the clinical and 3 Tesla MRA results in two groups of patients operated on for a medium-sized full-thickness rotator cuff tear with two different techniques. Methods The first group consisted of 20 patients operated on with the SR technique; the second group consisted of 20 patients operated on with the DR technique. All patients were evaluated at a minimum of 3 years after surgery. The primary end point was the re-tear rate at 3 Tesla MRA. The secondary end points were the Constant-Murley Scale (CMS), the Simple Shoulder Test (SST) scores, surgical time and implant expense. Results The mean follow-up was 40 months in the SR group and 38.9 months in the DR group. The mean postoperative CMS was 70 in the SR group and 68 in the DR group. The mean SST score was 9.4 in the SR group and 10.1 in the DR group. The re-tear rate was 60% in the SR group and 25% in the DR group. Leakage of the contrast medium was observed in all patients. Conclusions To the best of our knowledge, this is the first report on 3 Tesla MRA in the evaluation of two different techniques of rotator cuff repair. DR repair resulted in a statistically significant lower re-tear rate, with longer surgical time and higher implant expense, despite no

  17. Single-row vs. double-row arthroscopic rotator cuff repair: clinical and 3 Tesla MR arthrography results

    Directory of Open Access Journals (Sweden)

    Tudisco Cosimo

    2013-01-01

    Full Text Available Abstract Background Arthroscopic rotator cuff repair has become popular in the last few years because it avoids large skin incisions and deltoid detachment and dysfunction. Earlier arthroscopic single-row (SR repair methods achieved only partial restoration of the original footprint of the tendons of the rotator cuff, while double-row (DR repair methods presented many biomechanical advantages and higher rates of tendon-to-bone healing. However, DR repair failed to demonstrate better clinical results than SR repair in clinical trials. MR imaging at 3 Tesla, especially with intra-articular contrast medium (MRA, showed a better diagnostic performance than 1.5 Tesla in the musculoskeletal setting. The objective of this study was to retrospectively evaluate the clinical and 3 Tesla MRA results in two groups of patients operated on for a medium-sized full-thickness rotator cuff tear with two different techniques. Methods The first group consisted of 20 patients operated on with the SR technique; the second group consisted of 20 patients operated on with the DR technique. All patients were evaluated at a minimum of 3 years after surgery. The primary end point was the re-tear rate at 3 Tesla MRA. The secondary end points were the Constant-Murley Scale (CMS, the Simple Shoulder Test (SST scores, surgical time and implant expense. Results The mean follow-up was 40 months in the SR group and 38.9 months in the DR group. The mean postoperative CMS was 70 in the SR group and 68 in the DR group. The mean SST score was 9.4 in the SR group and 10.1 in the DR group. The re-tear rate was 60% in the SR group and 25% in the DR group. Leakage of the contrast medium was observed in all patients. Conclusions To the best of our knowledge, this is the first report on 3 Tesla MRA in the evaluation of two different techniques of rotator cuff repair. DR repair resulted in a statistically significant lower re-tear rate, with longer surgical time and higher implant

  18. Single-row vs. double-row arthroscopic rotator cuff repair: clinical and 3 Tesla MR arthrography results.

    Science.gov (United States)

    Tudisco, Cosimo; Bisicchia, Salvatore; Savarese, Eugenio; Fiori, Roberto; Bartolucci, Dario A; Masala, Salvatore; Simonetti, Giovanni

    2013-01-27

    Arthroscopic rotator cuff repair has become popular in the last few years because it avoids large skin incisions and deltoid detachment and dysfunction. Earlier arthroscopic single-row (SR) repair methods achieved only partial restoration of the original footprint of the tendons of the rotator cuff, while double-row (DR) repair methods presented many biomechanical advantages and higher rates of tendon-to-bone healing. However, DR repair failed to demonstrate better clinical results than SR repair in clinical trials. MR imaging at 3 Tesla, especially with intra-articular contrast medium (MRA), showed a better diagnostic performance than 1.5 Tesla in the musculoskeletal setting. The objective of this study was to retrospectively evaluate the clinical and 3 Tesla MRA results in two groups of patients operated on for a medium-sized full-thickness rotator cuff tear with two different techniques. The first group consisted of 20 patients operated on with the SR technique; the second group consisted of 20 patients operated on with the DR technique. All patients were evaluated at a minimum of 3 years after surgery. The primary end point was the re-tear rate at 3 Tesla MRA. The secondary end points were the Constant-Murley Scale (CMS), the Simple Shoulder Test (SST) scores, surgical time and implant expense. The mean follow-up was 40 months in the SR group and 38.9 months in the DR group. The mean postoperative CMS was 70 in the SR group and 68 in the DR group. The mean SST score was 9.4 in the SR group and 10.1 in the DR group. The re-tear rate was 60% in the SR group and 25% in the DR group. Leakage of the contrast medium was observed in all patients. To the best of our knowledge, this is the first report on 3 Tesla MRA in the evaluation of two different techniques of rotator cuff repair. DR repair resulted in a statistically significant lower re-tear rate, with longer surgical time and higher implant expense, despite no difference in clinical outcomes. We think that

  19. Concept of an accelerator-driven subcritical research reactor within the TESLA accelerator installation

    International Nuclear Information System (INIS)

    Pesic, Milan; Neskovic, Nebojsa

    2006-01-01

    Study of a small accelerator-driven subcritical research reactor in the Vinca Institute of Nuclear Sciences was initiated in 1999. The idea was to extract a beam of medium-energy protons or deuterons from the TESLA accelerator installation, and to transport and inject it into the reactor. The reactor core was to be composed of the highly enriched uranium fuel elements. The reactor was designated as ADSRR-H. Since the use of this type of fuel elements was not recommended any more, the study of a small accelerator-driven subcritical research reactor employing the low-enriched uranium fuel elements began in 2004. The reactor was designated as ADSRR-L. We compare here the results of the initial computer simulations of ADSRR-H and ADSRR-L. The results have confirmed that our concept could be the basis for designing and construction of a low neutron flux model of the proposed accelerator-driven subcritical power reactor to be moderated and cooled by lead. Our objective is to study the physics and technologies necessary to design and construct ADSRR-L. The reactor would be used for development of nuclear techniques and technologies, and for basic and applied research in neutron physics, metrology, radiation protection and radiobiology

  20. Studies on a VUV free electron laser at the TESLA Test Facility at DESY

    Energy Technology Data Exchange (ETDEWEB)

    Rossbach, J. [Deutsches Elektronen-Synchrotron, Hamburg (Germany)

    1995-12-31

    The TESLA Test Facility (TTF) currently under construction at DESY is a test-bed for acceleration sections of a high-gradient, high efficiency superconducting linear collider. Due to ist unrivaled ability to sustain high beam quality during acceleration, a superconducting rf linac is considered the optimum choice to drive a Free Electron Laser (FEL). We aim at a photon wavelength of {lambda} = 6 manometer utilizing the TTF after is has been extended to 1 GeV beam energy. Due to lack of mirrors and seed-lasers in this wavelength regime, a single pass FEL and Self-Amplified-Spontaneous-Emission (SASE) is considered. A first test is foreseen at a larger photon wavelength. The overall design as well as both electron and photon beam properties will be discussed. To reach the desired photon wavelength, the main components that have to be added to the TTF are: (a) a low emittance rf gun including space charge compensation (b) a two stage bunch compressor increasing the peak bunch current from 100 A up to 2500 A (c) four more accelerating modules to achieve 1 GeV beam energy (d) a 25 m long undulator (period length 27 mm, peak field 0.5 T) The average brillance will be larger than 1-10{sup 22}photons/s/mm{sup 2}/mrad{sup 2}/0.1%. Each 800 {mu}s long pulse will contain up to 7200 equidistant bunches. The repetition frequency of the linac is 10 Hz.

  1. Data transmission optical link for LLRF TESLA project part I: hardware structure of OPT0 module

    Science.gov (United States)

    Pozniak, Krzysztof T.; Romaniuk, Ryszard S.; Jalmuzna, Wojciech; Olowski, Krzysztof; Perkuszewski, Karol; Zielinski, Jerzy; Kierzkowski, Krzysztof

    2006-03-01

    It may be predicted now, even assuming a very conservative approach, that the next generation of the Low Level RF control systems for future accelerators will use extensively such technologies like: very fast programmable circuits equipped with DSP, embedded PC and optical communication I/O functionalities, as well as multi-gigabit optical transmission of measurement data and control signals. The paper presents the idea and realization of a gigabit synchronous data distributor designed to work in the LLRF control system of TESLA technology based X-ray FEL. The design bases on a relatively simple and cheap FPGA chip Cyclone. Commercially available SERDES (serializer/deserializer) and optical transceiver chips were applied. The optoelectronic module is embedded on the main LLRF BMB (backbone mother board). The MB provides communication with the outside computer control system, programmable chip configuration, integration with other functional modules and power supply. The hardware implementation is here described and the used software for BER (bit-error-rate) testing of the multi-gigabit optical link. The measurement results are presented. The appendix contains a comparison between the available protocols of serial data transmission for FPGA technology. This paper is a partial contribution to the next version of the SIMCON system which is expected to be released this year. The SIMCON, ver 3.0 will contain 8 channels and multi-gigabit optical transmission capability. It will be a fully modular construction.

  2. Horizontal nystagmus and multiple sclerosis using 3-Tesla magnetic resonance imaging.

    Science.gov (United States)

    Iyer, P M; Fagan, A J; Meaney, J F; Colgan, N C; Meredith, S D; Driscoll, D O; Curran, K M; Bradley, D; Redmond, J

    2016-11-01

    Nystagmus in patients with multiple sclerosis (MS) is generally attributed to brainstem disease. Lesions in other regions may result in nystagmus. The identification of these other sites is enhanced by using 3-Tesla magnetic resonance imaging (3TMRI) due to increased signal-to-noise ratio. We sought to evaluate the distribution of structural lesions and disruption of tracts in patients with horizontal nystagmus secondary to MS using 3TMRI. Twenty-four patients (20 women, 4 men; age range 26-55 years) with horizontal nystagmus secondary to MS underwent 3TMRI brain scans; and 18 patients had diffusion tensor imaging (DTI) for tractography. Nystagmus was bidirectional in 11, right-sided in 6 and left-sided in 7. We identified 194 lesions in 20 regions within the neural integrator circuit in 24 patients; 140 were within the cortex and 54 were within the brainstem. Only two patients had no lesions in the cortex, and 9 had no lesions in the brainstem. There was no relationship between side of lesion and direction of nystagmus. Thirteen of 18 (72 %) had tract disruption with fractional anisotropy (FA) values below 0.2. FA was significantly lower in bidirectional compared to unidirectional nystagmus (p = 0.006). In MS patients with horizontal nystagmus, lesions in all cortical eye fields and their descending connections were evident. Technical improvements in tractography may help identify the specific site(s) resulting in nystagmus in MS.

  3. Cognitive Function and 3-Tesla Magnetic Resonance Imaging Tractography of White Matter Hyperintensities in Elderly Persons

    Directory of Open Access Journals (Sweden)

    William Reginold

    2015-10-01

    Full Text Available Background/Aims: This study used 3-Tesla magnetic resonance imaging (MRI tractography to determine if there was an association between tracts crossing white matter hyperintensities (WMH and cognitive function in elderly persons. Methods: Brain T2-weighted fluid-attenuated inversion recovery (FLAIR and diffusion tensor MRI scans were acquired in participants above the age of 60 years. Twenty-six persons had WMH identified on T2 FLAIR scans. They completed a battery of neuropsychological tests and were classified as normal controls (n = 15 or with Alzheimer's dementia (n = 11. Tractography was generated by the Fiber Assignment by Continuous Tracking method. All tracts that crossed WMH were segmented. The average fractional anisotropy and average mean diffusivity of these tracts were quantified. We studied the association between cognitive test scores with the average mean diffusivity and average fractional anisotropy of tracts while controlling for age, total WMH volume and diagnosis. Results: An increased mean diffusivity of tracts crossing WMH was associated with worse performance on the Wechsler Memory Scale-III Longest Span Forward (p = 0.02. There was no association between the fractional anisotropy of tracts and performance on cognitive testing. Conclusion: The mean diffusivity of tracts crossing WMH measured by tractography is a novel correlate of performance on the Wechsler Memory Scale-III Longest Span Forward in elderly persons.

  4. Cognitive Function and 3-Tesla Magnetic Resonance Imaging Tractography of White Matter Hyperintensities in Elderly Persons.

    Science.gov (United States)

    Reginold, William; Luedke, Angela C; Tam, Angela; Itorralba, Justine; Fernandez-Ruiz, Juan; Reginold, Jennifer; Islam, Omar; Garcia, Angeles

    2015-01-01

    This study used 3-Tesla magnetic resonance imaging (MRI) tractography to determine if there was an association between tracts crossing white matter hyperintensities (WMH) and cognitive function in elderly persons. Brain T2-weighted fluid-attenuated inversion recovery (FLAIR) and diffusion tensor MRI scans were acquired in participants above the age of 60 years. Twenty-six persons had WMH identified on T2 FLAIR scans. They completed a battery of neuropsychological tests and were classified as normal controls (n = 15) or with Alzheimer's dementia (n = 11). Tractography was generated by the Fiber Assignment by Continuous Tracking method. All tracts that crossed WMH were segmented. The average fractional anisotropy and average mean diffusivity of these tracts were quantified. We studied the association between cognitive test scores with the average mean diffusivity and average fractional anisotropy of tracts while controlling for age, total WMH volume and diagnosis. An increased mean diffusivity of tracts crossing WMH was associated with worse performance on the Wechsler Memory Scale-III Longest Span Forward (p = 0.02). There was no association between the fractional anisotropy of tracts and performance on cognitive testing. The mean diffusivity of tracts crossing WMH measured by tractography is a novel correlate of performance on the Wechsler Memory Scale-III Longest Span Forward in elderly persons.

  5. Advanced MR methods at ultra-high field (7 Tesla) for clinical musculoskeletal applications

    Energy Technology Data Exchange (ETDEWEB)

    Trattnig, Siegfried [Medical University of Vienna/Vienna General Hospital, MR Centre - High Field MR, Department of Radiology, Vienna (Austria); Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Vienna (Austria); Zbyn, Stefan; Schmitt, Benjamin; Friedrich, Klaus; Bogner, Wolfgang [Medical University of Vienna/Vienna General Hospital, MR Centre - High Field MR, Department of Radiology, Vienna (Austria); Juras, Vladimir; Szomolanyi, Pavol [Medical University of Vienna/Vienna General Hospital, MR Centre - High Field MR, Department of Radiology, Vienna (Austria); Slovak Academy of Sciences, Department of Imaging Methods, Institute of Measurement Science, Bratislava (Slovakia)

    2012-11-15

    This article provides an overview of the initial clinical results of musculoskeletal studies performed at 7 Tesla, with special focus on sodium imaging, new techniques such as chemical exchange saturation transfer (CEST) and T2* imaging, and multinuclear MR spectroscopy. Sodium imaging was clinically used at 7 T in the evaluation of patients after cartilage repair procedures because it enables the GAG content to be monitored over time. Sodium imaging and T2* mapping allow insights into the ultra-structural composition of the Achilles tendon and help detect early disease. Chemical exchange saturation transfer was, for the first time, successfully applied in the clinical set-up at 7 T in patients after cartilage repair surgery. The potential of phosphorus MR spectroscopy in muscle was demonstrated in a comparison study between 3 and 7 T, with higher spectral resolution and significantly shorter data acquisition times at 7 T. These initial clinical studies demonstrate the potential of ultra-high field MR at 7 T, with the advantage of significantly improved sensitivity for other nuclei, such as {sup 23}Na (sodium) and {sup 31}P (phosphorus). The application of non-proton imaging and spectroscopy provides new insights into normal and abnormal physiology of musculoskeletal tissues, particularly cartilage, tendons, and muscles. (orig.)

  6. 7.0 tesla MRI brain white matter atlas. 2. ed.

    International Nuclear Information System (INIS)

    Cho, Zang-Hee

    2015-01-01

    Depicts the visualization of brain white matter with the latest 7.0 T MRI and TDI techniques. Represents a useful addition to brain research and clinical settings, such as the Human Connectome Project. Contains a wealth of exquisitely detailed color images. The introduction of techniques that permit visualization of the human nervous system is one of the foremost advances in neuroscience and brain-related research. Among the most recent significant developments in this respect are ultra-high field MRI and the image post-processing technique known as track density imaging (TDI). It is these techniques (including super-resolution TDI) which represent the two major components of 7.0 Tesla MRI - Brain White Matter Atlas. This second edition of the atlas has been revised and updated to fully reflect current application of these technological advancements in order to visualize the nervous system and the brain with the finest resolution and sensitivity. Exquisitely detailed color images offer neuroscientists, neurologists, and neurosurgeons a superb resource that will be of value both for the purpose of research and for the treatment of common brain diseases such as Alzheimer's disease and multiple sclerosis.

  7. Performance Analysis of Memory Transfers and GEMM Subroutines on NVIDIA Tesla GPU Cluster

    Energy Technology Data Exchange (ETDEWEB)

    Allada, Veerendra, Benjegerdes, Troy; Bode, Brett

    2009-08-31

    Commodity clusters augmented with application accelerators are evolving as competitive high performance computing systems. The Graphical Processing Unit (GPU) with a very high arithmetic density and performance per price ratio is a good platform for the scientific application acceleration. In addition to the interconnect bottlenecks among the cluster compute nodes, the cost of memory copies between the host and the GPU device have to be carefully amortized to improve the overall efficiency of the application. Scientific applications also rely on efficient implementation of the BAsic Linear Algebra Subroutines (BLAS), among which the General Matrix Multiply (GEMM) is considered as the workhorse subroutine. In this paper, they study the performance of the memory copies and GEMM subroutines that are critical to port the computational chemistry algorithms to the GPU clusters. To that end, a benchmark based on the NetPIPE framework is developed to evaluate the latency and bandwidth of the memory copies between the host and the GPU device. The performance of the single and double precision GEMM subroutines from the NVIDIA CUBLAS 2.0 library are studied. The results have been compared with that of the BLAS routines from the Intel Math Kernel Library (MKL) to understand the computational trade-offs. The test bed is a Intel Xeon cluster equipped with NVIDIA Tesla GPUs.

  8. Experimental coal dust suppression system installed at the Nikola Tesla thermal power plant

    Energy Technology Data Exchange (ETDEWEB)

    Guzijan, D [Rudarski Institut, Belgrade (Yugoslavia). Zavod za Ventilaciju i Tehnicku Zastitu

    1988-01-01

    Describes a project conducted at the Nikola Tesla thermal power plant by the Mining Institute of Belgrade to reduce the high levels of dust concentrations in overloading stations on coal conveyors and hoppers. A mathematical model was developed to determine the ventilation capacity required at each of the 18 overloading stations with the hoppers considered successively: empty, 1/3 full, 2/3 full and completely full. Shows how this model enabled an efficient dust suppression system to be developed and subsequently installed by the Termovent company in Belgrade using 4 axial ventilators supplied by the Ventilator Company in Zagreb. The ventilators were powered by means of 5.5 kW electric motors and provided 440 Pa pressure at 950 rpm. Gives the result of dust concentration measurements indicating that the installed system achieved the results predicted by the mathematical model and that the levels were well below the statutory limit. A description of the complete installation is included. 3 refs.

  9. Investigation of coal dust explosion hazard at the Nikola Tesla-A thermal power station

    Energy Technology Data Exchange (ETDEWEB)

    Golubovic, D

    1987-10-01

    Reports on investigations into coal dust explosion hazards in working places with high coal dust exposure, done in the Tesla-A thermal power station by Mining Institute of Belgrade specialists. Settled and floating coal dust concentrations were monitored for six months and samples analyzed for explosibility under lab conditions. Samples from transport and preparation facilities and the power station boiler house were taken. The entire plant was divided into 4 zones, depending on intensity of dust settlement and ventilation system. Coal dust generation varied from 0.3-65 g/min. Daily dust settlement ranged between 40 and 300 g/m/sup 2/. Total quantity of accumulated coal dust in the power plant ranged from 0.8-650 kg/day; 250 g/m/sup 3/ of coal dust may cause an explosion. Thus, a dangerous amount of coal dust, depending on work-site, will settle in 3.3.-21.8 days. Disturbance of settled dust may create explodable clouds. Details of measurements taken and data evaluation are included. 4 refs.

  10. Double-bundle depiction of the anterior cruciate ligament at 3 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Adriaensen, M.E.A.P.M. [Atrium Medical Center Parkstad, Department of Radiology, Heerlen (Netherlands); Hogan, B. [Sports Surgery Clinic, Department of Radiology, Dublin (Ireland); Al-Bulushi, H.I.J. [Armed Forces Hospital, Department of Radiology, Muscat (Oman); Kavanagh, E.C. [Mater Misericordiae Hospital, Department of Radiology, Dublin (Ireland)

    2012-07-15

    Magnetic resonance imaging on 3 Tesla (3T MRI) with arthroscopic correlation has proven to adequately identify the anteromedial bundle (AMB) and posterolateral bundle (PLB) in cadaver knees. The purpose of this study was to describe the depiction of ACL bundle anatomy on 3T MRI in daily practice. In a retrospective cohort study, we included 50 consecutive patients who underwent standard 3T MRI of the knee and had an intact ACL. Two musculoskeletal radiologists independently reviewed all scans for depiction of ACL bundle anatomy using standardized forms. Descriptive statistics were used. Twenty-three right knees (46%) and 27 left knees (54%) were included in the study. Mean age of the patients was 35 years (range 12 to 68 years); 37 patients were male (74%). ACL bundle anatomy was best depicted in the axial plane in 44 knees (88%) and in the coronal plane in six knees (12%). Two bundles were seen in 47 knees (94%). The AMB was completely seen in 45 knees (90%). The PLB was completely seen in 40 knees (80%). Both bundles were completely seen in 37 knees (76%). The double-bundle anatomy of the ACL is visualized in 94% of patients on 3T MRI. Because of potentially associated clinical benefits, we advocate to report separately on the anteromedial bundle and posterolateral bundle in case of anterior cruciate ligament injury of the knee. (orig.)

  11. Veins in plaques of multiple sclerosis patients - a longitudinal magnetic resonance imaging study at 7 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Dal-Bianco, Assunta; Auff, Eduard; Leutmezer, Fritz; Vass, Karl [Medical University of Vienna, Department of Neurology, Wien (Austria); Hametner, Simon [Medical University of Vienna, Center for Brain Research, Wien (Austria); Grabner, Guenther; Schernthaner, Melanie; Kronnerwetter, Claudia; Trattnig, Siegfried [Medical University of Vienna, Department of Radiology, Wien (Austria); Reitner, Andreas; Vass, Clemens; Kircher, Karl [Medical University of Vienna, Department of Ophthalmology, Wien (Austria)

    2015-10-15

    To monitor the venous volumes in plaques of patients with multiple sclerosis (MS) compared to an age-matched control group over a period of 3.5 years. Ten MS patients underwent an annual neurological examination and MRI. Susceptibility-weighted imaging (SWI) combined with fluid-attenuated inversion recovery (FLAIR) or FLAIR-like contrast at 7 Tesla (7 T) magnetic resonance imaging (MRI) was used for manual segmentation of veins in plaques, in the normal-appearing white matter (NAWM) and in location-matched white matter of 9 age-matched controls. Venous volume to tissue volume ratio was assessed for each time point in order to describe the dynamics of venous volumes in MS plaques over time. MS plaques, which were newly detected during the study period, showed significantly higher venous volumes compared to the preplaque area 1 year before plaque detection and the corresponding NAWM regions. Venous volumes in established MS plaques, which were present already in the first scans, were significantly higher compared to the NAWM and controls. Our data underpin a relation of veins and plaque development in MS and reflect increased apparent venous calibers due to increased venous diameters or increased oxygen consumption in early MS plaques. (orig.)

  12. 7.0 tesla MRI brain white matter atlas. 2. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Zang-Hee (ed.) [Gachon Univ., Incheon (Korea, Republic of). Neuroscience Research Institute

    2015-04-01

    Depicts the visualization of brain white matter with the latest 7.0 T MRI and TDI techniques. Represents a useful addition to brain research and clinical settings, such as the Human Connectome Project. Contains a wealth of exquisitely detailed color images. The introduction of techniques that permit visualization of the human nervous system is one of the foremost advances in neuroscience and brain-related research. Among the most recent significant developments in this respect are ultra-high field MRI and the image post-processing technique known as track density imaging (TDI). It is these techniques (including super-resolution TDI) which represent the two major components of 7.0 Tesla MRI - Brain White Matter Atlas. This second edition of the atlas has been revised and updated to fully reflect current application of these technological advancements in order to visualize the nervous system and the brain with the finest resolution and sensitivity. Exquisitely detailed color images offer neuroscientists, neurologists, and neurosurgeons a superb resource that will be of value both for the purpose of research and for the treatment of common brain diseases such as Alzheimer's disease and multiple sclerosis.

  13. Performance Analysis of Memory Transfers and GEMM Subroutines on NVIDIA Tesla GPU Cluster

    International Nuclear Information System (INIS)

    Allada, Veerendra; Benjegerdes, Troy; Bode, Brett

    2009-01-01

    Commodity clusters augmented with application accelerators are evolving as competitive high performance computing systems. The Graphical Processing Unit (GPU) with a very high arithmetic density and performance per price ratio is a good platform for the scientific application acceleration. In addition to the interconnect bottlenecks among the cluster compute nodes, the cost of memory copies between the host and the GPU device have to be carefully amortized to improve the overall efficiency of the application. Scientific applications also rely on efficient implementation of the BAsic Linear Algebra Subroutines (BLAS), among which the General Matrix Multiply (GEMM) is considered as the workhorse subroutine. In this paper, they study the performance of the memory copies and GEMM subroutines that are critical to port the computational chemistry algorithms to the GPU clusters. To that end, a benchmark based on the NetPIPE framework is developed to evaluate the latency and bandwidth of the memory copies between the host and the GPU device. The performance of the single and double precision GEMM subroutines from the NVIDIA CUBLAS 2.0 library are studied. The results have been compared with that of the BLAS routines from the Intel Math Kernel Library (MKL) to understand the computational trade-offs. The test bed is a Intel Xeon cluster equipped with NVIDIA Tesla GPUs.

  14. Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users.

    Science.gov (United States)

    Cowan, Ronald L; Bolo, Nicolas R; Dietrich, Mary; Haga, Erica; Lukas, Scott E; Renshaw, Perry F

    2007-08-15

    The recreational drug MDMA (3,4, methylenedioxymethamphetamine; sold under the street name of Ecstasy) is toxic to serotonergic axons in some animal models of MDMA administration. In humans, MDMA use is associated with alterations in markers of brain function that are pronounced in occipital cortex. Among neuroimaging methods, magnetic resonance spectroscopy (MRS) studies of brain metabolites N-acetylaspartate (NAA) and myoinositol (MI) at a field strength of 1.5 Tesla (T) reveal inconsistent results in MDMA users. Because higher field strength proton MRS has theoretical advantages over lower field strengths, we used proton MRS at 4.0 T to study absolute concentrations of occipital cortical NAA and MI in a cohort of moderate MDMA users (n=9) versus non-MDMA using (n=7) controls. Mean NAA in non-MDMA users was 10.47 mM (+/-2.51), versus 9.83 mM (+/-1.94) in MDMA users. Mean MI in non-MDMA users was 7.43 mM (+/-.68), versus 6.57 mM (+/-1.59) in MDMA users. There were no statistical differences in absolute metabolite levels for NAA and MI in occipital cortex of MDMA users and controls. These findings are not supportive of MDMA-induced alterations in NAA or MI levels in this small sample of moderate MDMA users. Limitations to this study suggest caution in the interpretation of these results.

  15. Partial epilepsy: A pictorial review of 3 TESLA magnetic resonance imaging features

    Directory of Open Access Journals (Sweden)

    Lucas Giansante Abud

    2015-09-01

    Full Text Available Epilepsy is a disease with serious consequences for patients and society. In many cases seizures are sufficiently disabling to justify surgical evaluation. In this context, Magnetic Resonance Imaging (MRI is one of the most valuable tools for the preoperative localization of epileptogenic foci. Because these lesions show a large variety of presentations (including subtle imaging characteristics, their analysis requires careful and systematic interpretation of MRI data. Several studies have shown that 3 Tesla (T MRI provides a better image quality than 1.5 T MRI regarding the detection and characterization of structural lesions, indicating that high-field-strength imaging should be considered for patients with intractable epilepsy who might benefit from surgery. Likewise, advanced MRI postprocessing and quantitative analysis techniques such as thickness and volume measurements of cortical gray matter have emerged and in the near future, these techniques will routinely enable more precise evaluations of such patients. Finally, the familiarity with radiologic findings of the potential epileptogenic substrates in association with combined use of higher field strengths (3 T, 7 T, and greater and new quantitative analytical post-processing techniques will lead to improvements regarding the clinical imaging of these patients. We present a pictorial review of the major pathologies related to partial epilepsy, highlighting the key findings of 3 T MRI.

  16. Impact of high strength electromagnetic fields generated by Tesla transformer on plant cell ultrastructure

    Directory of Open Access Journals (Sweden)

    Anna Rusakova

    2017-09-01

    Full Text Available Non-thermal effects of direct electric fields and alternating electromagnetic fields (EMF have been successfully used in a number of studies and applications in agriculture and biotechnology. Among different kinds of high strength EMF generators, the Tesla transformer (TT is known as a widely applied, low cost, and troubleproof device, which generates EMF in the range of 2–8 MHz. Despite of a number of developed and perspective applications of high strength EMFs in agriculture and biotechnology, the EMFs generated by TT, as well as the 1–50 MHz range of high strength EMF still remain unexplored in the fields of plant physiology, ultrastructure studies and biochemistry. In this work, we have shown that TT-EMFs (4 MHz induced fast stem and petiole bending, disappearance of cell organelles, vacuolar membranes, and increase of a non-photochemical chlorophyll fluorescence quenching in petioles. It is intriguing that such fatal effects can be evoked in plants by EMFs which are well known as harmless for man at the applied strength and frequency.

  17. Two-Slotted Surface Coil Array for Magnetic Resonance Imaging at 4 Tesla

    International Nuclear Information System (INIS)

    Solis, S. E.; Hernandez, J. A.; Rodriguez, A. O.; Tomasi, D.

    2008-01-01

    Arrays of antennas have been widely accepted for magnetic resonance imaging applications due to their high signal-to-noise ratio (SNR) over large volumes of interest. A new surface coil based on the magnetron tube and called slotted surface coil, has been recently introduced by our group. This coil design experimentally demonstrated a significant improvement over the circular-shaped coil when used in the receive-only mode. The slotted coils formed a two-sheet structure with a 90 deg. separation and each coil had 6 circular slots. Numerical simulations were performed using the finite element method for this coil design to study the behaviour of the array magnetic field. Then, we developed a two-coil array for brain magnetic resonance imaging to be operated at the resonant frequency of 170 MHz in the transceiver mode. Phantom images were acquired with our coil array and standard pulse sequences on a research-dedicated 4 Tesla scanner. Numerical simulations demonstrated that electromagnetic interaction between the coil elements is negligible, and that the magnetic field showed a good uniformity. In vitro images showed the feasibility of this coil array for standard pulses for high field magnetic resonance imaging

  18. Test Results for HD1, a 16 Tesla Nb3Sn Dipole Magnet

    International Nuclear Information System (INIS)

    Lietzke, A.F.; Bartlett, S.; Bish, P.; Caspi, S.; Chiesa, L.; Dietderich, D.; Ferracin, P.; Gourlay, S.A.; Goli, M.; Hafalia, R.R.; Higley, H.; Hannaford, R.; Lau, W.; Liggens, N.; Mattafirri, S.; McInturff, A.; Nyman, M.; Sabbi, G.; Scanlan, R.; Swanson, J.

    2003-01-01

    The Superconducting Magnet Group at Lawrence Berkeley National Laboratory has been developing the technology for using brittle superconductor in high-field accelerator magnets. HD1, the latest in a series of magnets, contains two, double-layer Nb 3 Sn flat racetrack coils. This single-bore dipole configuration, using the highest performance conductor available, was designed and assembled for a 16 tesla conductor/structure/pre-stress proof-of-principle. With the combination of brittle conductor and high Lorentz stress, considerable care was taken to predict the magnet's mechanical responses to pre-stress, cool-down, and excitation. Subsequent cold testing satisfied expectations: Training started at 13.6 T, 83% of 'short-sample', achieved 90% in 10 quenches, and reached its peak bore field (16 T) after 19 quenches. The average plateau, ∼92% of 'short-sample', appeared to be limited by 'stick-slip' conductor motions, consistent with the 16.2 T conductor 'lift-off' pre-stress that was chosen for this first test. Some lessons learned and some implications for future conductor and magnet technology development are presented and discussed.

  19. A 32-channel lattice transmission line array for parallel transmit and receive MRI at 7 tesla.

    Science.gov (United States)

    Adriany, Gregor; Auerbach, Edward J; Snyder, Carl J; Gözübüyük, Ark; Moeller, Steen; Ritter, Johannes; Van de Moortele, Pierre-François; Vaughan, Tommy; Uğurbil, Kâmil

    2010-06-01

    Transmit and receive RF coil arrays have proven to be particularly beneficial for ultra-high-field MR. Transmit coil arrays enable such techniques as B(1) (+) shimming to substantially improve transmit B(1) homogeneity compared to conventional volume coil designs, and receive coil arrays offer enhanced parallel imaging performance and SNR. Concentric coil arrangements hold promise for developing transceiver arrays incorporating large numbers of coil elements. At magnetic field strengths of 7 tesla and higher where the Larmor frequencies of interest can exceed 300 MHz, the coil array design must also overcome the problem of the coil conductor length approaching the RF wavelength. In this study, a novel concentric arrangement of resonance elements built from capacitively-shortened half-wavelength transmission lines is presented. This approach was utilized to construct an array with whole-brain coverage using 16 transceiver elements and 16 receive-only elements, resulting in a coil with a total of 16 transmit and 32 receive channels. (c) 2010 Wiley-Liss, Inc.

  20. Novel 16-channel receive coil array for accelerated upper airway MRI at 3 Tesla.

    Science.gov (United States)

    Kim, Yoon-Chul; Hayes, Cecil E; Narayanan, Shrikanth S; Nayak, Krishna S

    2011-06-01

    Upper airway MRI can provide a noninvasive assessment of speech and swallowing disorders and sleep apnea. Recent work has demonstrated the value of high-resolution three-dimensional imaging and dynamic two-dimensional imaging and the importance of further improvements in spatio-temporal resolution. The purpose of the study was to describe a novel 16-channel 3 Tesla receive coil that is highly sensitive to the human upper airway and investigate the performance of accelerated upper airway MRI with the coil. In three-dimensional imaging of the upper airway during static posture, 6-fold acceleration is demonstrated using parallel imaging, potentially leading to capturing a whole three-dimensional vocal tract with 1.25 mm isotropic resolution within 9 sec of sustained sound production. Midsagittal spiral parallel imaging of vocal tract dynamics during natural speech production is demonstrated with 2 × 2 mm(2) in-plane spatial and 84 ms temporal resolution. Copyright © 2010 Wiley-Liss, Inc.

  1. Quadrature transmit coil for breast imaging at 7 tesla using forced current excitation for improved homogeneity.

    Science.gov (United States)

    McDougall, Mary Preston; Cheshkov, Sergey; Rispoli, Joseph; Malloy, Craig; Dimitrov, Ivan; Wright, Steven M

    2014-11-01

    To demonstrate the use of forced current excitation (FCE) to create homogeneous excitation of the breast at 7 tesla, insensitive to the effects of asymmetries in the electrical environment. FCE was implemented on two breast coils: one for quadrature (1) H imaging and one for proton-decoupled (13) C spectroscopy. Both were a Helmholtz-saddle combination, with the saddle tuned to 298 MHz for imaging and 75 MHz for spectroscopy. Bench measurements were acquired to demonstrate the ability to force equal currents on elements in the presence of asymmetric loading to improve homogeneity. Modeling and temperature measurements were conducted per safety protocol. B1 mapping, imaging, and proton-decoupled (13) C spectroscopy were demonstrated in vivo. Using FCE to ensure balanced currents on elements enabled straightforward tuning and maintaining of isolation between quadrature elements of the coil. Modeling and bench measurements confirmed homogeneity of the field, which resulted in images with excellent fat suppression and in broadband proton-decoupled carbon-13 spectra. FCE is a straightforward approach to ensure equal currents on multiple coil elements and a homogeneous excitation field, insensitive to the effects of asymmetries in the electrical environment. This enabled effective breast imaging and proton-decoupled carbon-13 spectroscopy at 7T. © 2014 Wiley Periodicals, Inc.

  2. A Novel X-ray Diffractometer for the Florida Split Coil 25 Tesla Magnet

    Science.gov (United States)

    Wang, Shengyu; Kovalev, Alexey; Suslov, Alexey; Siegrist, Theo

    2014-03-01

    At National High Magnetic Field Laboratory (NHMFL), we are developing a unique X-ray diffractometer for the 25 Tesla Florida Split Coil Magnet for scattering experiments under extremely high static magnetic fields. The X-ray source is a sealed tube (copper or molybdenum anode), connected to the magnet by an evacuated beam tunnel. The detectors are either an image plate or a silicon drift detector, with the data acquisition system based on LabVIEW. Our preliminary experimental results showed that the performance of the detector electronics and the X-ray generator is reliable in the fringe magnetic fields produced at the highest field of 25 T. Using this diffractometer, we will make measurements on standard samples, such as LaB6, Al2O3 and Si, to calibrate the diffraction system. Magnetic samples, such as single crystal HoMnO3 and stainless steel 301 alloys will be measured subsequently. The addition of X-ray diffraction to the unique split coil magnet will significantly expand the NHMFL experimental capabilities. Therefore, external users will be able to probe spin - lattice interactions at static magnetic fields up to 25T. This project is supported by NSF-DMR Award No.1257649. NHMFL is supported by NSF Cooperative Agreement No. DMR-1157490, the State of Florida, and the U.S. DoE.

  3. Breast MRI at 7 Tesla with a bilateral coil and robust fat suppression.

    Science.gov (United States)

    Brown, Ryan; Storey, Pippa; Geppert, Christian; McGorty, KellyAnne; Klautau Leite, Ana Paula; Babb, James; Sodickson, Daniel K; Wiggins, Graham C; Moy, Linda

    2014-03-01

    To develop a bilateral coil and fat suppressed T1-weighted sequence for 7 Tesla (T) breast MRI. A dual-solenoid coil and three-dimensional (3D) T1w gradient echo sequence with B1+ insensitive fat suppression (FS) were developed. T1w FS image quality was characterized through image uniformity and fat-water contrast measurements in 11 subjects. Signal-to-noise ratio (SNR) and flip angle maps were acquired to assess the coil performance. Bilateral contrast-enhanced and unilateral high resolution (0.6 mm isotropic, 6.5 min acquisition time) imaging highlighted the 7T SNR advantage. Reliable and effective FS and high image quality was observed in all subjects at 7T, indicating that the custom coil and pulse sequence were insensitive to high-field obstacles such as variable tissue loading. 7T and 3T image uniformity was similar (P=0.24), indicating adequate 7T B1+ uniformity. High 7T SNR and fat-water contrast enabled 0.6 mm isotropic imaging and visualization of a high level of fibroglandular tissue detail. 7T T1w FS bilateral breast imaging is feasible with a custom radiofrequency (RF) coil and pulse sequence. Similar image uniformity was achieved at 7T and 3T, despite different RF field behavior and variable coil-tissue interaction due to anatomic differences that might be expected to alter magnetic field patterns. Copyright © 2013 Wiley Periodicals, Inc.

  4. Performance of external and internal coil configurations for prostate investigations at 7 Tesla

    Science.gov (United States)

    Metzger, Gregory J.; van de Moortele, Pierre-Francois; Akgun, Can; Snyder, Carl J.; Moeller, Steen; Strupp, John; Andersen, Peter; Shrivastava, Devashish; Vaughan, Tommy; Ugurbil, Kamil; Adriany, Gregor

    2010-01-01

    Three different coil configurations were evaluated through simulation and experimentally to determine safe operating limits and evaluate subject size dependent performance for prostate imaging at 7 Tesla. The coils included a transceiver endorectal coil (trERC), a 16 channel transceiver external surface array (trESA) and a trESA combined with a receive-only ERC (trESA+roERC). While the transmit B1 (B1+) homogeneity was far superior for the trESA, the maximum achievable B1+ is subject size dependent and limited by transmit chain losses and amplifier performance. For the trERC, limitations in transmit homogeneity greatly compromised image quality and limited coverage of the prostate. Despite these challenges, the high peak B1+ close to the trERC and subject size independent performance provides potential advantages especially for spectroscopic localization where high bandwidth RF pulses are required. On the receive side, the combined trESA+roERC provided the highest SNR and improved homogeneity over the trERC resulting in better visualization of the prostate and surrounding anatomy. In addition, the parallel imaging performance of the trESA+roERC holds strong promise for diffusion weighted imaging and dynamic contrast enhanced MRI. PMID:20740657

  5. Feasibility of high-resolution pituitary MRI at 7.0 tesla

    International Nuclear Information System (INIS)

    Rotte, Alexandra A.J. de; Kolk, Anja G. van der; Rutgers, Dik; Luijten, Peter R.; Hendrikse, Jeroen; Zelissen, Pierre M.J.; Visser, Fredy

    2014-01-01

    Since the pituitary gland measures 3-8 mm, imaging with the highest possible spatial resolution is important for the detection of even smaller lesions such as those seen in Cushing's disease. In the current feasibility study, we tested a multi-sequence MRI protocol to visualize the pituitary gland in high resolution at 7.0 Tesla (7.0 T). Ten healthy volunteers were examined with a 7.0 T pituitary gland protocol. The protocol consisted of a T1-weighted magnetization-prepared inversion recovery (MPIR) turbo spin-echo (TSE) sequence and a T2-weighted TSE sequence. Additionally, this protocol was tested in five patients with clinical and biochemical suspicion of a microadenoma. The dedicated protocol was successful in visualizing normal pituitary anatomy. At 7.0 T compared to 1.5 T, four times as many slices covered the pituitary gland in sagittal and coronal direction. In three patients, a lesion was diagnosed at 7.0 T, and was confirmed by histopathology to be a microadenoma. Head-to-head comparisons of 7.0 T with 1.5 T and 3.0 T are needed with larger samples of patients and with imaging times feasible for clinical settings. However, the current study suggests that high-resolution 7.0 T MRI of the pituitary gland may provide new perspectives when used as a second-line diagnostic examination in the specific context of Cushing's disease. (orig.)

  6. Feasibility of high-resolution pituitary MRI at 7.0 tesla

    Energy Technology Data Exchange (ETDEWEB)

    Rotte, Alexandra A.J. de; Kolk, Anja G. van der; Rutgers, Dik; Luijten, Peter R.; Hendrikse, Jeroen [University Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, Postbox 85500, Utrecht (Netherlands); Zelissen, Pierre M.J. [University Medical Center Utrecht, Department of Internal Medicine (Section of Endocrinology), Utrecht (Netherlands); Visser, Fredy [University Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, Postbox 85500, Utrecht (Netherlands); Philips Healthcare, Best (Netherlands)

    2014-08-15

    Since the pituitary gland measures 3-8 mm, imaging with the highest possible spatial resolution is important for the detection of even smaller lesions such as those seen in Cushing's disease. In the current feasibility study, we tested a multi-sequence MRI protocol to visualize the pituitary gland in high resolution at 7.0 Tesla (7.0 T). Ten healthy volunteers were examined with a 7.0 T pituitary gland protocol. The protocol consisted of a T1-weighted magnetization-prepared inversion recovery (MPIR) turbo spin-echo (TSE) sequence and a T2-weighted TSE sequence. Additionally, this protocol was tested in five patients with clinical and biochemical suspicion of a microadenoma. The dedicated protocol was successful in visualizing normal pituitary anatomy. At 7.0 T compared to 1.5 T, four times as many slices covered the pituitary gland in sagittal and coronal direction. In three patients, a lesion was diagnosed at 7.0 T, and was confirmed by histopathology to be a microadenoma. Head-to-head comparisons of 7.0 T with 1.5 T and 3.0 T are needed with larger samples of patients and with imaging times feasible for clinical settings. However, the current study suggests that high-resolution 7.0 T MRI of the pituitary gland may provide new perspectives when used as a second-line diagnostic examination in the specific context of Cushing's disease. (orig.)

  7. MR-guided discography using an open 1 Tesla MRI system

    International Nuclear Information System (INIS)

    Streitparth, Florian; Bucourt, M. de; Hamm, B.; Teichgraeber, U.; Hartwig, T.; Strube, P.; Putzier, M.; Schnackenburg, B.; Chopra, S.

    2011-01-01

    To evaluate the feasibility of MR-guided discography using an open 1 Tesla MRI system. 48 disc segments of 41 patients scheduled for intradiscal thermal treatment, total disc replacement or spondylodesis were examined. A 1.0-T open MRI was used for instrument guidance and imaging. After primary disc puncture under guidance of interactive PDw TSE imaging, 1-2 ml of gadolinium contrast saline mixture was injected into the disc. The occurrence of memory pain during injection was recorded. Axial and sagittal T1w TSE images with and without fat saturation were obtained. All MRI discograms were analysed by two readers, who were blinded to the clinical findings. Overall, the placement of the puncture needle in the targeted disc was accurate under real-time MR guidance. Injections were technically successful in all cases. No major complications occurred. The mean procedure time was 17 min (range 13-34 min). Image quality of contrast-enhanced MR discograms was excellent when using an optimized gadolinium contrast saline mixture of 1:600. Memory pain was detected in 16 out of 48 affected segments. MR-guided discography is accurate and safe. Multiplanar dynamic imaging facilitates the puncture of discs and provides high-quality MR discograms. (orig.)

  8. Monitoring the electron beam position at the TESLA test facility free electron laser

    Energy Technology Data Exchange (ETDEWEB)

    Kamps, T

    2000-06-14

    The operation of a free electron laser working in the Self Amplified Spontaneous Emission mode (SASE FEL) requires the electron trajectory to be aligned with very high precision in overlap with the photon beam. In order to ensure this overlap, one module of the SASE FEL undulator at the TESLA Test Facility (TTF) is equipped with a new type of waveguide beam position monitor (BPM). Four waveguides are arranged symmetrically around the beam pipe, each channel couples through a small slot to the electromagnetic beam field. The induced signal depends on the beam intensity and on the transverse beam position in terms of beam-to-slot distance. With four slot--waveguide combinations a linear position sensitive signal can be achieved, which is independent of the beam intensity. The signals transduced by the slots are transferred by ridged waveguides through an impedance matching stage into a narrowband receiver tuned to 12 GHz. The present thesis describes design, tests, and implementation of this new type of BPM. (orig.)

  9. Blood oxygen-level dependent functional assessment of cerebrovascular reactivity: Feasibility for intraoperative 3 Tesla MRI.

    Science.gov (United States)

    Fierstra, Jorn; Burkhardt, Jan-Karl; van Niftrik, Christiaan Hendrik Bas; Piccirelli, Marco; Pangalu, Athina; Kocian, Roman; Neidert, Marian Christoph; Valavanis, Antonios; Regli, Luca; Bozinov, Oliver

    2017-02-01

    To assess the feasibility of functional blood oxygen-level dependent (BOLD) MRI to evaluate intraoperative cerebrovascular reactivity (CVR) at 3 Tesla field strength. Ten consecutive neurosurgical subjects scheduled for a clinical intraoperative MRI examination were enrolled in this study. In addition to the clinical protocol a BOLD sequence was implemented with three cycles of 44 s apnea to calculate CVR values on a voxel-by-voxel basis throughout the brain. The CVR range was then color-coded and superimposed on an anatomical volume to create high spatial resolution CVR maps. Ten subjects (mean age 34.8 ± 13.4; 2 females) uneventfully underwent the intraoperative BOLD protocol, with no complications occurring. Whole-brain CVR for all subjects was (mean ± SD) 0.69 ± 0.42, whereas CVR was markedly higher for tumor subjects as compared to vascular subjects, 0.81 ± 0.44 versus 0.33 ± 0.10, respectively. Furthermore, color-coded functional maps could be robustly interpreted for a whole-brain assessment of CVR. We demonstrate that intraoperative BOLD MRI is feasible in creating functional maps to assess cerebrovascular reactivity throughout the brain in subjects undergoing a neurosurgical procedure. Magn Reson Med 77:806-813, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  10. Dynamic Multi-Coil Shimming of the Human Brain at 7 Tesla

    Science.gov (United States)

    Juchem, Christoph; Nixon, Terence W.; McIntyre, Scott; Boer, Vincent O.; Rothman, Douglas L.; de Graaf, Robin A.

    2011-01-01

    High quality magnetic field homogenization of the human brain (i.e. shimming) for MR imaging and spectroscopy is a demanding task. The susceptibility differences between air and tissue are a longstanding problem as they induce complex field distortions in the prefrontal cortex and the temporal lobes. To date, the theoretical gains of high field MR have only been realized partially in the human brain due to limited magnetic field homogeneity. A novel shimming technique for the human brain is presented that is based on the combination of non-orthogonal basis fields from 48 individual, circular coils. Custom-built amplifier electronics enabled the dynamic application of the multi-coil shim fields in a slice-specific fashion. Dynamic multi-coil (DMC) shimming is shown to eliminate most of the magnetic field inhomogeneity apparent in the human brain at 7 Tesla and provided improved performance compared to state-of-the-art dynamic shim updating with zero through third order spherical harmonic functions. The novel technique paves the way for high field MR applications of the human brain for which excellent magnetic field homogeneity is a prerequisite. PMID:21824794

  11. Contrast enhanced renal MR angiography at 7 Tesla: How much gadolinium do we need?

    Energy Technology Data Exchange (ETDEWEB)

    Beiderwellen, Karsten, E-mail: karsten.beiderwellen@uni-due.de [Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen (Germany); Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen (Germany); Kraff, Oliver, E-mail: Oliver.kraff@uni-due.de [Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen (Germany); Laader, Anja, E-mail: anja.laader@uk-essen.de [Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen (Germany); Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen (Germany); Maderwald, Stefan, E-mail: Stefan.maderwald@uni-due.de [Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen (Germany); Orzada, Stephan, E-mail: Stephan.orzada@uni-due.de [Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen (Germany); Ladd, Mark E., E-mail: mark.ladd@dkfz-heidelberg.de [Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg (Germany); Forsting, Michael, E-mail: Michael.forsting@uk-essen.de [Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen (Germany); Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen (Germany); Lauenstein, Thomas C., E-mail: Thomas.Lauenstein@uni-due.de [Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen (Germany); Umutlu, Lale, E-mail: Lale.umutlu@uk-essen.de [Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen (Germany); Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen (Germany)

    2017-01-15

    Objectives: To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality. Methods: Ten healthy volunteers were enrolled for a renal MRA on a 7 T scanner. Fast low angle shot (FLASH) MRA data sets were obtained utilizing three different doses of Gadobutrol (0.1, 0.05 and 0.025 mmol/kg body weight [BW]). Contrast ratios (CR) were measured in the aorta as well as in the intra- and extraparenchymal arteries compared to the psoas muscle. Qualitative analysis regarding the delineation of vessel structures was performed using a four-point-scale. Results: All doses of Gadobutrol allowed for a good delineation of the aorta and renal arteries. For the extra- and intraparenchymal segmental arteries higher values were observed for full and half dose in comparison to quarter dose. No significant difference was observed for full and half dose. A lower CR was observed for quarter compared to half dose (p < 0.05) for the renal arteries. Conclusions: While best results were observed for half and full dose, a dose reduction to 0.025 mmol/kg BW is justifiable, maintaining a diagnostic image quality. This may be of high interest considering patients with renal impairment.

  12. Veins in plaques of multiple sclerosis patients - a longitudinal magnetic resonance imaging study at 7 Tesla

    International Nuclear Information System (INIS)

    Dal-Bianco, Assunta; Auff, Eduard; Leutmezer, Fritz; Vass, Karl; Hametner, Simon; Grabner, Guenther; Schernthaner, Melanie; Kronnerwetter, Claudia; Trattnig, Siegfried; Reitner, Andreas; Vass, Clemens; Kircher, Karl

    2015-01-01

    To monitor the venous volumes in plaques of patients with multiple sclerosis (MS) compared to an age-matched control group over a period of 3.5 years. Ten MS patients underwent an annual neurological examination and MRI. Susceptibility-weighted imaging (SWI) combined with fluid-attenuated inversion recovery (FLAIR) or FLAIR-like contrast at 7 Tesla (7 T) magnetic resonance imaging (MRI) was used for manual segmentation of veins in plaques, in the normal-appearing white matter (NAWM) and in location-matched white matter of 9 age-matched controls. Venous volume to tissue volume ratio was assessed for each time point in order to describe the dynamics of venous volumes in MS plaques over time. MS plaques, which were newly detected during the study period, showed significantly higher venous volumes compared to the preplaque area 1 year before plaque detection and the corresponding NAWM regions. Venous volumes in established MS plaques, which were present already in the first scans, were significantly higher compared to the NAWM and controls. Our data underpin a relation of veins and plaque development in MS and reflect increased apparent venous calibers due to increased venous diameters or increased oxygen consumption in early MS plaques. (orig.)

  13. Comparison of T1-weighted 2D TSE, 3D SPGR, and two-point 3D Dixon MRI for automated segmentation of visceral adipose tissue at 3 Tesla.

    Science.gov (United States)

    Fallah, Faezeh; Machann, Jürgen; Martirosian, Petros; Bamberg, Fabian; Schick, Fritz; Yang, Bin

    2017-04-01

    To evaluate and compare conventional T1-weighted 2D turbo spin echo (TSE), T1-weighted 3D volumetric interpolated breath-hold examination (VIBE), and two-point 3D Dixon-VIBE sequences for automatic segmentation of visceral adipose tissue (VAT) volume at 3 Tesla by measuring and compensating for errors arising from intensity nonuniformity (INU) and partial volume effects (PVE). The body trunks of 28 volunteers with body mass index values ranging from 18 to 41.2 kg/m 2 (30.02 ± 6.63 kg/m 2 ) were scanned at 3 Tesla using three imaging techniques. Automatic methods were applied to reduce INU and PVE and to segment VAT. The automatically segmented VAT volumes obtained from all acquisitions were then statistically and objectively evaluated against the manually segmented (reference) VAT volumes. Comparing the reference volumes with the VAT volumes automatically segmented over the uncorrected images showed that INU led to an average relative volume difference of -59.22 ± 11.59, 2.21 ± 47.04, and -43.05 ± 5.01 % for the TSE, VIBE, and Dixon images, respectively, while PVE led to average differences of -34.85 ± 19.85, -15.13 ± 11.04, and -33.79 ± 20.38 %. After signal correction, differences of -2.72 ± 6.60, 34.02 ± 36.99, and -2.23 ± 7.58 % were obtained between the reference and the automatically segmented volumes. A paired-sample two-tailed t test revealed no significant difference between the reference and automatically segmented VAT volumes of the corrected TSE (p = 0.614) and Dixon (p = 0.969) images, but showed a significant VAT overestimation using the corrected VIBE images. Under similar imaging conditions and spatial resolution, automatically segmented VAT volumes obtained from the corrected TSE and Dixon images agreed with each other and with the reference volumes. These results demonstrate the efficacy of the signal correction methods and the similar accuracy of TSE and Dixon imaging for automatic volumetry of VAT at 3 Tesla.

  14. Low molecular weight components in an aquatic humic substance as characterized by membrane dialysis and orbitrap mass spectrometry.

    Science.gov (United States)

    Remucal, Christina K; Cory, Rose M; Sander, Michael; McNeill, Kristopher

    2012-09-04

    Suwannee River fulvic acid (SRFA) was dialyzed through a 100-500 molecular weight cutoff dialysis membrane, and the dialysate and retentate were analyzed by UV-visible absorption and high-resolution Orbitrap mass spectrometry (MS). A significant fraction (36% based on dissolved organic carbon) of SRFA passed through the dialysis membrane. The fraction of SRFA in the dialysate had a different UV-visible absorption spectrum and was enriched in low molecular weight molecules with a more aliphatic composition relative to the initial SRFA solution. Comparison of the SRFA spectra collected by Orbitrap MS and Fourier transform ion cyclotron resonance MS (FT-ICR MS) demonstrated that the mass accuracy of the Orbitrap MS is sufficient for determination of unique molecular formulas of compounds with masses masses detected by Orbitrap MS were found in the 100-200 Da mass range. Many of these low molecular masses corresponded to molecular formulas of previously identified compounds in organic matter, lignin, and plants, and the use of the standard addition method provided an upper concentration estimate of selected target compounds in SRFA. Collectively, these results provide evidence that SRFA contains low molecular weight components that are present individually or in loosely bound assemblies.

  15. Novel molecular-level evidence of iodine binding to natural organic matter from Fourier transform ion cyclotron resonance mass spectrometry

    International Nuclear Information System (INIS)

    Xu, Chen; Chen, Hongmei; Sugiyama, Yuko; Zhang, Saijin; Li, Hsiu-Ping; Ho, Yi-Fang; Chuang, Chia-ying; Schwehr, Kathleen A.; Kaplan, Daniel I.; Yeager, Chris; Roberts, Kimberly A.; Hatcher, Patrick G.; Santschi, Peter H.

    2013-01-01

    Major fractions of radioiodine ( 129 I) are associated with natural organic matter (NOM) in the groundwater and surface soils of the Savannah River Site (SRS). Electrospray ionization coupled to Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) was applied to elucidate the interactions between inorganic iodine species (iodide and iodate) and a fulvic acid (FA) extracted from a SRS surface soil. Iodate is likely reduced to reactive iodine species by the lignin- and tannin-like compounds or the carboxylic-rich alicyclic molecules (CRAM), during which condensed aromatics and lignin-like compounds were generated. Iodide is catalytically oxidized into reactive iodine species by peroxides, while FA is oxidized by peroxides into more aliphatic and less aromatic compounds. Only 9% of the total identified organo-iodine compounds derived from molecules originally present in the FA, whereas most were iodine binding to newly-produced compounds. The resulting iodinated molecules were distributed in three regions in the van Krevelen diagrams, denoting unsaturated hydrocarbons, lignin and protein. Moreover, characteristics of these organo-iodine compounds, such as their relatively low O/C ratios ( 2 or -HNCOR groups and a ring-activating functionality to favor the electrophilic substitution. The ESI-FTICR-MS technique provides novel evidence to better understand the reactivity and scavenging properties of NOM towards radioiodine and possible influence of NOM on 129 I migration. Highlights: ► IO 3 − reduced by lignin-, tannin-like compounds/carboxylic-rich alicyclic molecules ► Condensed aromatic and lignin-like compounds generated after iodate-iodination ► Aliphatic and less aromatic compounds formed after iodide-iodination ► Organo-iodine identified as unsaturated hydrocarbons, lignin and protein ► Organo-iodine with low O/C ratios imply less environmental mobility

  16. A database application for pre-processing, storage and comparison of mass spectra derived from patients and controls

    Directory of Open Access Journals (Sweden)

    Sillevis Smitt Peter A

    2006-09-01

    Full Text Available Abstract Background Statistical comparison of peptide profiles in biomarker discovery requires fast, user-friendly software for high throughput data analysis. Important features are flexibility in changing input variables and statistical analysis of peptides that are differentially expressed between patient and control groups. In addition, integration the mass spectrometry data with the results of other experiments, such as microarray analysis, and information from other databases requires a central storage of the profile matrix, where protein id's can be added to peptide masses of interest. Results A new database application is presented, to detect and identify significantly differentially expressed peptides in peptide profiles obtained from body fluids of patient and control groups. The presented modular software is capable of central storage of mass spectra and results in fast analysis. The software architecture consists of 4 pillars, 1 a Graphical User Interface written in Java, 2 a MySQL database, which contains all metadata, such as experiment numbers and sample codes, 3 a FTP (File Transport Protocol server to store all raw mass spectrometry files and processed data, and 4 the software package R, which is used for modular statistical calculations, such as the Wilcoxon-Mann-Whitney rank sum test. Statistic analysis by the Wilcoxon-Mann-Whitney test in R demonstrates that peptide-profiles of two patient groups 1 breast cancer patients with leptomeningeal metastases and 2 prostate cancer patients in end stage disease can be distinguished from those of control groups. Conclusion The database application is capable to distinguish patient Matrix Assisted Laser Desorption Ionization (MALDI-TOF peptide profiles from control groups using large size datasets. The modular architecture of the application makes it possible to adapt the application to handle also large sized data from MS/MS- and Fourier Transform Ion Cyclotron Resonance (FT-ICR mass

  17. A database application for pre-processing, storage and comparison of mass spectra derived from patients and controls.

    Science.gov (United States)

    Titulaer, Mark K; Siccama, Ivar; Dekker, Lennard J; van Rijswijk, Angelique L C T; Heeren, Ron M A; Sillevis Smitt, Peter A; Luider, Theo M

    2006-09-05

    Statistical comparison of peptide profiles in biomarker discovery requires fast, user-friendly software for high throughput data analysis. Important features are flexibility in changing input variables and statistical analysis of peptides that are differentially expressed between patient and control groups. In addition, integration the mass spectrometry data with the results of other experiments, such as microarray analysis, and information from other databases requires a central storage of the profile matrix, where protein id's can be added to peptide masses of interest. A new database application is presented, to detect and identify significantly differentially expressed peptides in peptide profiles obtained from body fluids of patient and control groups. The presented modular software is capable of central storage of mass spectra and results in fast analysis. The software architecture consists of 4 pillars, 1) a Graphical User Interface written in Java, 2) a MySQL database, which contains all metadata, such as experiment numbers and sample codes, 3) a FTP (File Transport Protocol) server to store all raw mass spectrometry files and processed data, and 4) the software package R, which is used for modular statistical calculations, such as the Wilcoxon-Mann-Whitney rank sum test. Statistic analysis by the Wilcoxon-Mann-Whitney test in R demonstrates that peptide-profiles of two patient groups 1) breast cancer patients with leptomeningeal metastases and 2) prostate cancer patients in end stage disease can be distinguished from those of control groups. The database application is capable to distinguish patient Matrix Assisted Laser Desorption Ionization (MALDI-TOF) peptide profiles from control groups using large size datasets. The modular architecture of the application makes it possible to adapt the application to handle also large sized data from MS/MS- and Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry experiments. It is expected that the

  18. Test Results of HD1b, an upgraded 16 Tesla Nb3Sn Dipole Magnet

    International Nuclear Information System (INIS)

    Lietzke, A.F.; Bartlett, S.E.; Bish, P.; Caspi, S.; Dietderich, D.; Ferracin, P.; Gourlay, S.; Hafalia, A.R.; Hannaford, C.R.; Higley, H.; Lau, W.; Liggins, N.; Mattafirri, S.; Nyman, M.; Sabbi, G.; Scanlan, R.; Swanson, J.

    2005-01-01

    The Superconducting Magnet Group at Lawrence Berkeley National Laboratory has been developing high-field, brittle-superconductor, accelerator magnet technology, in which the conductor's support system can significantly impact conductor performance (as well as magnet training). A recent H-dipole coil test (HD1) achieved a peak bore-field of 16 Tesla, using two, flat-racetrack, double-layer Nb 3 Sn coils. However, its 4.5 K training was slow, with an erratic plateau at ∼92% of its un-degraded ''short-sample'' expectation (∼16.6 T). Quench-origins correlated with regions where low conductor pre-stress had been expected (3-D FEM predictions and variations in 300 K coil-size). The coils were re-assembled with minor coil-support changes and re-tested as ''HD1b'', with a 185 MPa average pre-stress (30 MPa higher than HD1, with a 15-20 MPa pole-turn margin expected at 17 T). Training started higher (15.1 T), and quickly reached a stable, negligibly higher plateau at 16 T. After a thermal cycle, training started at 15.4 T, but peaked at 15.8 T, on the third attempt, before degrading to a 15.7 T plateau. The temperature dependence of this plateau was explored in a sub-atmospheric LHe bath to 3.0 K. Magnet performance data for both thermal cycles is presented and discussed, along with issues for future high-field accelerator magnet development

  19. Synchronic, optical transmission data link integrated with FPGA circuits (for TESLA LLRF control system)

    Energy Technology Data Exchange (ETDEWEB)

    Zielinski, J.S.

    2006-07-15

    The X-ray free-electron laser X-FEL that is being planned at the DESY research center in cooperation with European partners will produce high-intensity ultra-short X-ray flashes with the properties of laser light. This new light source, which can only be described in terms of superlatives, will open up a whole range of new possibilities for the natural sciences. It could also offer very promising opportunities for industrial users. SIMCON (SIMulator and CONtroller) is the project of the fast, low latency digital controller dedicated to the LLRF1 system in VUV FEL experiment It is being developed by the ELHEP2 group in the Institute of Electronic Systems at Warsaw University of Technology. The main purpose of the project is to create a controller to stabilize the vector sum of fields in cavities of one cryo-module in the experiment. The device can