WorldWideScience

Sample records for territorio il supporto

  1. Il telerilevamento a supporto dell’Augmented Reality

    Directory of Open Access Journals (Sweden)

    Filippo Gemma

    2011-04-01

    Full Text Available Fondere insieme realtà e oggetti virtuali per muoversi al meglio con efficacia ed efficienza è quanto si propone, tramite la  Realtà Aumentata, la AGI, Analytical Graphics Inc. di Exton (USA, distribuita in esclusiva in Italia da GMSPAZIO che offre il sistema STK, storicamente conosciuto come Satellite ToolKit che offre più di quarantamila utenti nel mondo un esteso set di funzionalità capaci di soddisfare ogni tipo di esigenza.Remote  Sensing  and  Augmented RealityAugmented reality has been used for years  in  the  broadcast  industry.  You see it every time the National Football League paints a yellow first-down line on the playing field. While it is com-monplace and easy to execute in con-trolled environments with fixed cam-era  positions,  predetermined  angles and known terrain, the opposite is true in uncontrolled environments, such as battlefields in Kandahar. Nonetheless, augmented reality is essential for the warfighter, and the global intelligence community (IC is faced with the chal-lenge  of  efficiently  creating  and  dis-seminating intelligence products from increasing  amounts  of  video  data. AGI’s  Insight3D  development  library is helping to overcome many hurdles of ISR-focused augmented reality.

  2. Il telerilevamento a supporto dell’Augmented Reality

    Directory of Open Access Journals (Sweden)

    Filippo Gemma

    2011-04-01

    Full Text Available Fondere insieme realtà e oggetti virtuali per muoversi al meglio con efficacia ed efficienza è quanto si propone, tramite la  Realtà Aumentata, la AGI, Analytical Graphics Inc. di Exton (USA, distribuita in esclusiva in Italia da GMSPAZIO che offre il sistema STK, storicamente conosciuto come Satellite ToolKit che offre più di quarantamila utenti nel mondo un esteso set di funzionalità capaci di soddisfare ogni tipo di esigenza. Remote  Sensing  and  Augmented Reality Augmented reality has been used for years  in  the  broadcast  industry.  You see it every time the National Football League paints a yellow first-down line on the playing field. While it is com-monplace and easy to execute in con-trolled environments with fixed cam-era  positions,  predetermined  angles and known terrain, the opposite is true in uncontrolled environments, such as battlefields in Kandahar. Nonetheless, augmented reality is essential for the warfighter, and the global intelligence community (IC is faced with the chal-lenge  of  efficiently  creating  and  dis-seminating intelligence products from increasing  amounts  of  video  data. AGI’s  Insight3D  development  library is helping to overcome many hurdles of ISR-focused augmented reality.

  3. Il telerilevamento a supporto dell’Augmented Reality

    Directory of Open Access Journals (Sweden)

    Filippo Gemma

    2012-04-01

    Full Text Available Fondere insieme realtà e oggetti virtuali per muoversi al meglio con efficacia ed efficienza è quanto si propone, tramite la  Realtà Aumentata, la AGI, Analytical Graphics Inc. di Exton (USA, distribuita in esclusiva in Italia da GMSPAZIO che offre il sistema STK, storicamente conosciuto come Satellite ToolKit che offre più di quarantamila utenti nel mondo un esteso set di funzionalità capaci di soddisfare ogni tipo di esigenza.Remote  Sensing  and  Augmented RealityAugmented reality has been used for years  in  the  broadcast  industry.  You see it every time the National Football League paints a yellow first-down line on the playing field. While it is com-monplace and easy to execute in con-trolled environments with fixed cam-era  positions,  predetermined  angles and known terrain, the opposite is true in uncontrolled environments, such as battlefields in Kandahar. Nonetheless, augmented reality is essential for the warfighter, and the global intelligence community (IC is faced with the chal-lenge  of  efficiently  creating  and  dis-seminating intelligence products from increasing  amounts  of  video  data. AGI’s  Insight3D  development  library is helping to overcome many hurdles of ISR-focused augmented reality.

  4. Il sistema EGNOS a supporto della navigazione sicura nei porti: il progetto SafePort

    Directory of Open Access Journals (Sweden)

    Antonio Casoria

    2012-09-01

    Full Text Available Il progetto SafePort, sviluppato all’interno del 7° Programma Quadro promosso dalla Unione Europea con la supervisione di European GNSS Agency (GSA che segue tutti i programmi applicativi inerenti ai sistemi GNSS europei, Galileo ed EGNOS, ha l’obbiettivo di migliorare la capacità recettiva dei porti europei, aumentando al contempo la sicurezza delle operazioni di navigazione, di attracco e di ormeggio. The EGNOS system to support safe navigation in ports: the project SafePORT SafePORT The project, developed within the 7 th Framework Programme  sponsored  by  European  Union  under  the  super-vision of European GNSS Agency (GSA, which follows all ap-plications relating to the European GNSS systems, Galileo and EGNOS, has the aim to improve receptive capacity of Europe-an ports, while increasing the safety of operations, navigation, docking and mooring.

  5. Integrare paesaggio, ambiente e territorio. Il caso del Piano Territoriale di Coordinamento Provinciale di Crotone

    Directory of Open Access Journals (Sweden)

    Concetta Fallanca

    2013-01-01

    Full Text Available Nel perseguimento di una pianificazione e gestione equilibrata del territorio l’Ente Provinciale ha un ruolo strategico in quanto chiamato a recepire e mettere in atto i metodi e gli strumenti messi in campo per una nuova politica del paesaggio. Il Piano Territoriale di Coordinamento Provinciale risulta essere lo strumento ideale di sperimentazione per integrare paesaggio-ambiente e territorio, poiché assume come obiettivo principale la sostenibilità ambientale connessa allo sviluppo socio-economico, coniugando l’evoluzione del territorio alla qualità dell’ambiente ed alla conservazione dei paesaggi, in una logica di compatibilità fra trasformazione e uso delle risorse secondo la loro capacità di carico e riproducibilità

  6. Disegno e gestione dell’ occupazione territoriale con il supporto del Telerilevamento e dei Sistemi Informativi Geografici - Bassi costi e grandi benefici in Brasile

    Directory of Open Access Journals (Sweden)

    Thaísa Daniele Apóstolo Nogueira

    2013-05-01

    Full Text Available L’articolo affronta applicazioni su metodologie di analisi spaziale supportate da geoprocessing, in municipi brasiliani, con la disponibilità di dati di dominio pubblico e di software liberi. Si è analizzato come caso di studio, la municipalità di Ribeirão das Neves, nello stato di Minas Gerais, Brasile. È stato strutturato un Sistema di Informazione Geografica per la municipalità, come parte del Programma di Qualificazione del Ministero delle Città, in collaborazione con l'Università Federale di Minas Gerais (UFMG, Laboratorio di Geoprocessing della Facoltà di Architettura. Le analisi spaziali permettono la caratterizzazione del paesaggio, l’identificazione delle aree di interesse di conservazione ambientale, le aree di interesse per l'espansione e la densità urbana e l’ubicazione di possibili conflitti di interesse nella occupazione del territorio. La metodologia è applicabile ad altri comuni e mira a rendere fondamentale il processo decisionale nella progettazione e nella gestione del paesaggio comunale, per garantire il suo sviluppo sostenibile. 

  7. Strategie di dissoluzione del supporto murale in Banksy e Blu

    OpenAIRE

    Flavio Pintarelli

    2011-01-01

    La Street Art si è configurata, fin dalla sua nascita, come una pratica artistica dal carattere fortemente antagonista. Lo spazio urbano è il teatro in cui questa pratica è protagonista ed il muro il suo palcoscenico. La Street Art ha spesso riflettuto sul proprio supporto e sulle sue caratteristiche costitutive, anche a livello metalinguistico. Il presente studio intende assumere come oggetto d'analisi alcune opere di due celebri street artisti: i murales animati dell'italiano Blu e quelli c...

  8. Il governo integrato del sistema trasporti-territorio nell’area vasta MTB Metropoli Terra di Bari

    Directory of Open Access Journals (Sweden)

    Enrica Papa

    2010-02-01

    Full Text Available  L’articolo propone il caso di studio dell’area vasta Metropoli Terra di Bari, e in particolare descrive come nella redazione del Piano Strategico BA2015 e nel piano della mobilità di Area Vasta PUM sia stato affrontato il tema della mobilità. La redazione in parallelo e congiunto dei due strumenti di pianificazione, uno generale per il governo del territorio ed uno settoriale per il governo della mobilità costituisce una best practice in Italia di governo integrato trasporti-territorio. L’articolo descrive i contenuti ed il processo per la redazione degli strumenti, evidenziando i punti di forza e i punti di debolezza dell’intero iter decisionale.

  9. Cineturismo e valorizzazione del territorio: il caso Puglia / Cine-tourism and territory enhancement: the case of Puglia region

    Directory of Open Access Journals (Sweden)

    Michele Vigilante

    2016-05-01

    Full Text Available Il cineturismo rappresenta un fenomeno socio-culturale recente e in forte diffusione in Italia. Il suo legame con la valorizzazione del territorio è inscindibile dal momento in cui lo spettatore sceglie un determinato luogo da visitare, stimolato dalla visione di un film, di una fiction o di un cortometraggio. La valorizzazione del territorio attraverso il cinema non è automatica. Vi sono luoghi che grazie a dei film di successo hanno riscontrato un afflusso esponenziale di turisti e altri luoghi dove questo non è avvenuto. Predisporre spazi per l'accoglienza di produzioni cinematografiche o finanziare le produzioni cinematografiche in uno specifico territorio consente un maggiore interesse, da parte dei registi, nei confronti di quelle location che di quel territorio fanno parte.  The film tourism is a socio-cultural phenomenon recently and rapidly spread in Italy. His connection with the development of the area is inseparable from the moment when the viewer chooses a certain place to visit, stimulated by watching a movie, a drama or a short film. The development of the area through cinema is not automatic. There are places that thanks to the hit movie found an exponential influx of tourists and other places where this has not happened. Provide space for the reception of film productions or finance film productions in a specific area allows a greater interest on the part of directors, in respect of those locations that are part of that territory.

  10. Il ruolo delle infrastrutture nella costruzione e nella percezione del territorio

    Directory of Open Access Journals (Sweden)

    Roberto Busi

    2012-08-01

    Full Text Available L’opera di pianificazione del paesaggio non può che passare attraverso la pianificazione delle componenti fisiche del territorio che, oltre agli indubitabili significati ed obiettivi funzionali, sono anche gli elementi costitutivi del paesaggio perché rappresentano le componenti percepibili del territorio medesimo; cosicché la pianificazione paesistica viene ad essere ad un tempo la diretta conseguenza e l’alta motivazione di quella urbanistico-territoriale conferendole motivi, fini e valori elevati.E le infrastrutture sono, come detto, le componenti fisiche primarie dell’antropizzazione del territorio sia in quanto tali, sia in quanto fattore per eccellenza di eventi generanti componenti fisiche.

  11. Agricoltura, paesaggio e territorio tra conservazione e innovazione: il ruolo della ricerca

    Directory of Open Access Journals (Sweden)

    Zeno Varanini

    Full Text Available Il paesaggio è un’entità spaziale complessa, nella quale troviamo registrate, sedimentate nel tempo, le trasformazioni di genere naturale e culturale, espresse con un linguaggio universalmente comprensibile in un testo unico e fragile. A questa concezione matura del paesaggio si può riferire il suo riconoscimento come indicatore di sintesi dello stato dell’ambiente, che l’ex Agenzia nazionale per la protezione dell’ambiente proponeva sul finire degli anni Novanta, indicando pertanto una possibile via, non semplice, né esaustiva, ma chiara e praticabile, per l’analisi e il progetto della sostenibilità dello sviluppo territoriale. La stessa definizione olistica che la Convenzione europea attribuisce al paesaggio costituisce una conferma ed un rafforzamento del suo significato quale esito primario delle modalità di sviluppo territoriale e pertanto della sua valenza di termine di valutazione delle relative condizioni di sostenibilità.

  12. La piattaforma logistica di Leixões, Portogallo, e il suo territorio.

    Directory of Open Access Journals (Sweden)

    Marco Campolongo

    2010-07-01

    Full Text Available L’obiettivo dell’articolo è l’analisi critica del progetto preliminare della piattaforma di Leixões, nell’area metropolitana di Porto, al fine di verificare le modalità con cui sono state affrontate le questioni relative alla connessione tra mobilità dedicata e mobilità ordinaria, il rapporto con i caratteri del sistema insediativo in cui l’area è inserita, le relazioni con le zone di protezione ambientale contigue alla parte meridionale del polo logistico. Sulla base di questa attenta disamina sono state avanzate delle ipotesi progettuali tese a modificare alcuni aspetti della impostazione insediativa del progetto, pur mantenendo sostanzialmente inalterato il layout d’insieme della struttura. L’articolo è organizzato in cinque sezioni. All’introduzione segue una breve descrizione del sistema logistico in Portogallo e del Piano nazionale della Logistica. La sezione 3 è dedicata alla presentazione del progetto preliminare della piattaforma di Leixões e la sezione 4 all’analisi critica di tale progetto e alle possibili ipotesi progettuali alternative. Seguono le considerazioni conclusive.

  13. Rilievo e modellazione 3D per lo studio delle chiese a pianta ovale in Sicilia: il caso di Santa Chiara a Catania.

    Directory of Open Access Journals (Sweden)

    Eugenio Magnano di San Lio

    2012-11-01

    Full Text Available Lo studio presentato fa parte di una ricerca più ampia volta alla documentazione e all’analisi degli edifici a pianta centrale, ellittica e ovale, presenti sul territorio siciliano e realizzati a cavallo del Settecento. La complessa geometria e la spazialità di questi ambienti necessitano di una metodologia di indagine che si avvale delle tecnologie più avanzate per il rilievo e la modellazione 3D – laser scanning - al fine di approfondire la lettura e l’interpretazione del testo architettonico su un supporto metrico accurato e denso di informazioni e comprendere le geometrie utilizzate nel progetto e nel tracciamento in cantiere.

  14. Abitare e conservare il patrimonio architettonico. Il caso del Convento di Cristo, 1979-2009.

    Directory of Open Access Journals (Sweden)

    Alvaro Barbosa

    2010-12-01

    Full Text Available Abitare è rimanere in un luogo. È interagire con lo spazio, il paesaggio, la natura e gli uomini. Il risultato di quest’azione permane come un segno nel territorio ed è trasmessa alle generazioni future col passare del tempo. In questo modo a si afferma il concetto di patrimonio associato all’azione dell’abitare un luogo sia questo una casa, sia un convento, una città, un paesaggio costruito, etc. I luoghi del patrimonio sono il supporto fisico della memoria sociale, la quale è trasmessa nell’atto stesso del vivere umano. Così la memoria degli uomini è radicata nel modo in cui loro abitano i luoghi. Togliere ai luoghi questa caratteristica di vita, questa funzione dell’abitare, riduce drasticamente il senso del patrimonio ed il suo ruolo di monumento, di memoria vivente. Cercare di mantenere vivo il patrimonio, nelle sue diverse valenze, è il compito principale della società odierna rispetto al patrimonio costruito. Si può affermare che oggi conosciamo tutte le soluzioni tecniche per la conservazione dei monumenti. Non disponiamo tuttavia delle soluzioni sociali capaci di mantenerli viventi e attuanti nel nostro mondo contemporaneo. Il caso del Convento di Cristo diventa un paradigma di questa lotta per una nuova strategia di conservazione centrata sul vivere i luoghi, sull’abitare il patrimonio.

  15. Il territorio delle Lipari tra ambiente, cinema e turismo / The territory of Lipari between environment, cinema and tourism

    Directory of Open Access Journals (Sweden)

    Elena Di Blasi

    2016-05-01

    Full Text Available Fino agli anni ’50 le Lipari (dette anche Eolie, sfavorite dall’insularità e con un’economia di sussistenza, basata su attività tradizionali, erano dominate da povertà ed emigrazione. Tutto mutò nel 1949, quando una troupe cinematografica, guidata da Rossellini, girò Stromboli, interpretato da Ingrid Bergman: tra i due era nata una storia d’amore. Poco dopo, un’altra troupe utilizzò Vulcano come location dell’omonimo film, con Anna Magnani, ex fiamma di Rossellini. Questi cult passarono alla storia del cinema come la guerra dei vulcani. I due film, con gli scoop legati alle vicende sentimentali dei protagonisti, hanno innescato un nuovo percorso per le Eolie, fuori dall’atavico letargo, che ha determinato un vero e proprio “boom turistico”. Indagando la variegata realtà delle Lipari, lo scopo del presente articolo è quello di dimostrare come, attraverso un’analisi storica del mercato turistico, l’arrivo del cinema nel territorio eoliano abbia innescato importanti processi di sviluppo economico e cambiamento sociale. Questa ricerca vuole, inoltre, evidenziare il rapporto privilegiato tra insularità e cineturismo. Till the late 50s the Aeolian Islands, plagued by insularity and characterized by a subsistence economy based on traditional activities, had been dominated by poverty and emigration. All changed in 1949 when Rossellini shot Stromboli featuring Ingrid Bergman, his new love. Soon after a crew shot in Volcano the homonymous film starring Anna Magnani, Rossellini’s old flame. The two films, gone down in history as the war of volcanoes, and the scoops about the love scandal have drawn a new path for the Aeolian Islands that has taken them to a tourist boom. The present paper aims to show by means of a historical analysis of the local tourist market how the coming of the film industry have triggered processes of economic growth and social change in the Aeolian Islands. This paper also aims to point out the

  16. Coastal dynamics physical and mathematical modelling, territorial analysis, G.I.S. instrumentation. The state of the arts; La dinamica costiera modellistica fisico-matematica, analisi del territorio, il supporto G.I.S. e la strumentazione in uso

    Energy Technology Data Exchange (ETDEWEB)

    De Bonis, P.; Fattorusso, G.; Onori, F.; Pagano, A.; Pasanisi, F.; Peloso, A.; Regina, P.; Tebano, C.; Zarlenga, F. [ENEA, Div. Caratterizzazione dell' Ambiente, Centro Ricerche Casaccia, S. Maria di Galeria, Rome (Italy)

    2001-07-01

    The aim of the present work is to offer, in a single volume, the basic notions relative to different aspects, both theoretical and practical, of the study of coastal dynamical processes. It has been dealt with geological issues, physical and mathematical modelling, effects related to human activities, Geographical Information Systems as well as both laboratory and fields instrumentations. Reading this technical paper it has to keep in mind two aspects which have been authors guidelines. First of all, the research theme's have been studied on their theoretical aspects, focusing on the most recent developments. Then have been selected some up to date experiences and discuss their application. The general framework of this publication, which necessarily leave out some particular issues, for which the readers are to be referred to the references, gives a synthetic and homogenous picture of the state of the arts in coastal modelling. [Italian] Lo scopo della presente pubblicazione e' quello di offrire, in un unico volume, le nozioni di base riguardo ai diversi argomenti sia teorici sia pratici relativi all'analisi delle dinamiche costiere. Sono stati affrontati i temi relativi alla geologia, alla modellistica fisica e matematica, ai fattori di pressione antropica, all'utilizzo di Sistemi Informativi Geografici e alla strumentazione sia di campo sia di laboratorio. Nello sviluppo del presente Rapporto Tecnico si possono individuare per ciascuna delle aree di interesse due aspetti fondamentali. Dapprima i temi di ricerca sono stati studiati da un punto di vista teorico generale, con attenzione agli sviluppi piu' attuali e successivamente sono state presentate alcune recenti esperienze ed applicazioni di tali conoscenze. L'impostazione generale del presente lavoro, che sicuramente porta a trascurare alcuni aspetti particolari, per i quali si rimanda alla bibliografia, fornisce in ogni caso un quadro sintetico ed organico dello stato dell'arte dello studio della modellistica costiera.

  17. Interoperabilità dei dati territoriali: il GN si dota di un nuovo servizio per la trasformazione di coordinate per l’intero territorio italiano

    Directory of Open Access Journals (Sweden)

    Salvatore Costabile

    2013-03-01

    Full Text Available Il servizio di trasformazione di coordinate (CTS, Coordinate Transformation Service è uno dei servizi ditrasformazione geometrica previsti dall’implementazione della direttiva 2007/2/CE INSPIRE. Le applicazioniWEB e WCTS messe a disposizione dal Geoportale Nazionale consentono a tutti gli utenti di eseguiretrasformazioni di coordinate sull’intero territorio italiano impiegando i grigliati rilasciati dall’IstitutoGeografico Militare Italiano (IGM.Abstract The Coordinate Transformation Service (CTS is one of theservices provided by the implementation of the geometric transformation of the INSPIRE Directive 2007/2/EC. WEB applications and WCTS service are provided by the National Geoportal (Geoportale Nazionale allowing all users to perform coordinate transformations on the entire Italian territory using also detailed grid value released by IGM (Italian Military Geographical Institute.  

  18. Interoperabilità dei dati territoriali: il GN si dota di un nuovo servizio per la trasformazione di coordinate per l’intero territorio italiano

    Directory of Open Access Journals (Sweden)

    Salvatore Costabile

    2013-03-01

    Full Text Available Il servizio di trasformazione di coordinate (CTS, Coordinate Transformation Service è uno dei servizi ditrasformazione geometrica previsti dall’implementazione della direttiva 2007/2/CE INSPIRE. Le applicazioniWEB e WCTS messe a disposizione dal Geoportale Nazionale consentono a tutti gli utenti di eseguiretrasformazioni di coordinate sull’intero territorio italiano impiegando i grigliati rilasciati dall’IstitutoGeografico Militare Italiano (IGM. Abstract The Coordinate Transformation Service (CTS is one of theservices provided by the implementation of the geometric transformation of the INSPIRE Directive 2007/2/EC. WEB applications and WCTS service are provided by the National Geoportal (Geoportale Nazionale allowing all users to perform coordinate transformations on the entire Italian territory using also detailed grid value released by IGM (Italian Military Geographical Institute.

  19. Il cibo come creatore di circoli virtuosi. Slow Food e Terra Madre, eccellenze nello sviluppo sostenibile del territorio.

    OpenAIRE

    Facchini, Andrea

    2010-01-01

    Punto di partenza per il lavoro presentato, sono le tematiche legate alle pratiche di consumo di cibo in un’ottica che superi una semplice visione utilitaristica delle stesse, mentre viene evidenziato invece il più profondo rapporto uomo-cibo e i fenomeni di socializzazione che ne scaturiscono. Si trovano pertanto a coniugarsi la sociologia dei consumi e la sociologia della cultura. La base per questa visione del cibo e delle pratiche di produzione e consumo ad esso collegate è l’ipotesi c...

  20. Campania: territorio e città di fronte alla sfida della logistica

    Directory of Open Access Journals (Sweden)

    Giuseppe Mazzeo

    2010-07-01

    Full Text Available All’interno del sistema territoriale meridionale la Regione Campania si presenta come un polo importante nel settore del trasporto e dello smistamento delle merci. Questo ruolo si è venuto rinforzando in seguito alla realizzazione di infrastrutture dedicate alla logistica, connesse ad infrastrutture di supporto. Il sistema campano presenta punte di eccellenza di livello nazionale che possono incentivare il ruolo della Regione in questo settore, ma presenta anche fattori negativi che possono rallentare il decollo del settore. Si fa riferimento alle strozzature infrastrutturali e gestionali che ne inceppano l’efficienza, ma anche alla debolezza del sistema produttivo regionale che non garantisce una massa critica locale alla logistica campana. Un terzo aspetto è la mancanza di un chiaro disegno di programmazione degli investimenti e una maggiore chiarezza dei ruoli da assegnare alle diverse iniziative, nate soprattutto sulla base di spinte localistiche non coordinate. Il paper analizza la situazione della logistica territoriale in Campania e delle sue interrelazioni territoriali individuando punti di forza e di debolezza e potenziali fattori evolutivi. Gli aspetti della logistica che vengono affrontati sono di tipo territoriale e si differenziano da quelli della logistica urbana per la quantità di merci movimentate e per la concentrazione in pochi poli strategici, in quanto queste piattaforme logistiche richiedono attrezzature specializzate e ampi spazi per la movimentazione e il deposito. L’analisi del rapporto tra territorio e logistica individua quelli che sono i principali elementi di interconnessione e, spesso, di crisi, nell’uso dello spazio fisico, in ragione degli obiettivi a volte divergenti tra il governo del territorio ed i soggetti economici. Si passa successivamente ad analizzare lo stato del movimento merci in relazione alla portualità mediterranea e lo stato del sistema logistico campano (non ancora definito in tutte le

  1. Strategie di dissoluzione del supporto murale in Banksy e Blu

    Directory of Open Access Journals (Sweden)

    Flavio Pintarelli

    2011-01-01

    Full Text Available Gli effetti di sfondamento della cornice e della superficie del supporto messi in campo dagli street artists Blu e Bansky permettono di creare alcuni slittamenti di senso relativi alle caratteristiche del muro inteso sia come elemento architettonico sia come elemento di controllo e separazione.

  2. Problematiche geoambientali del territorio veneziano

    OpenAIRE

    Bassan, Valentina; Carbognin, Laura; D'Ambrosi, F; Gobbo, L; Rizzetto, Cesare; Schiavon, Enrico; Scortegagna, Ugo; Tosi, Luigi; Vitturi, Andrea; Zangheri, Pietro

    1997-01-01

    Venezia, la sua laguna ed il territorio circostante sono un patrimonio artistico, storico, culturale ed ambientale tra i più noti al mondo. Il fragile equilibrio, tipico delle lagune, è per Venezia particolarmente vulnerabile; essa infatti risulta modellata da un forte contributo antropico, iniziato secoli or sono con le note deviazioni fluviali, ed è oggi esposta ad azioni antropiche di particolare rilevanza, quali quelle derivanti dalla presenza della zona industriale di Marghera che s'affa...

  3. Il fenomeno abachistico a supporto dei cambiamenti socio-economici: Arezzo tra il XIII ed il XVI secolo = The role of the abacus tradition for the economic and social development of the society: evidence from Tuscany (Italy between XIII and XVI century

    Directory of Open Access Journals (Sweden)

    Maria Pia Maraghini

    2011-12-01

    techniques to do arithmetic operations and practical rules to solve commercial and financial questions. The objective of this research is to further investigate the study of abacus schools and books, in order to recover and highlight the role held by the abacus phenomenon in the origins of the “accounting art” and, in general, the role of the “abacus tradition” for the economic and social development of the society during the medieval and renaissance period. To achieve this goal, the study relies upon some evidences from Tuscany (Italy between XIII and XVI century. By combining theoretical and empirical insights, the analysis points out the contribution the abacus tradition has given to the better development of public life in the city-republic during the medieval and renaissance period, that is to say to the best and most effective exercise of duty and civic right. This contribution has been the basis to the growing interest shown towards the abacus culture by the then city-republic authorities.La presente ricerca indaga sulle “origini” dell’arte contabile tendente a memorizzare i comportamenti economici. In particolare, essa esamina i primi “ambienti” specifici predisposti e organizzati per l’insegnamento delle conoscenze contabili e i “mezzi” di studio per il loro trasferimento: le scuole e i libri d’abaco. Diffusisi prevalentemente in Italia tra il XIII ed il XVI secolo, essi avevano il principale scopo di trasmettere quelle conoscenze generalmente definite di “matematica pratica”, quali le tecniche per eseguire le operazioni aritmetiche e le regole pratiche per la risoluzione di problemi commerciali e finanziari.L’obiettivo della ricerca è quello di approfondire lo studio delle scuole e dei libri d’abaco, evidenziandone il ruolo rivestito nella “genesi” della contabilità per le aziende e, quindi, nel più generale sviluppo socio-economico in epoca medioevale e nei primi secoli del Rinascimento.A tal fine, la ricerca si avvale

  4. Technical Consensus and Integration between Transport and Territory: the Bagnoli Project Consenso tecnico e integrazione trasporti-territorio: il Progetto Bagnoli

    Directory of Open Access Journals (Sweden)

    Antonio Di Luccio

    2011-02-01

    integrazione trasporti-territorio derivano non solo da un rigoroso iter progettuale, ma soprattutto da una articolata, lunga e spesso difficile attività di costruzione del consenso tecnico. Sono necessari più incontri, verifiche sul campo, rilievi, analisi specialistiche, ma anche di un tempo certo di chiusura di fasi significative del procedimento, scongiurando il rischio di un tempo infinito di discussione che non è mai compatibile con i tempi del finanziamento. La definizione del tracciato, ad esempio, è un momento di sintesi di molteplici istanze che devono essere accolte, che non trovano mai risoluzione immediata, ma solo dopo un iter ricorsivo che mette a posto prima i tasselli più grandi e via via quelli più piccoli del mosaico che si va a comporre. È un lavoro di squadra che coinvolge molteplici discipline e un gran numero di professionisti, che devono lavorare in stretto contatto, avendo cura che le informazioni circolino nella maniera corretta, che ci sia trasparenza e chiarezza nelle decisioni che man mano vengono adottate e che queste determinazioni siano note a tutti; tutti devono avere la disponibilità a rivedere parte del proprio lavoro o in casi estremi a ripartire daccapo. Una prima necessaria  fase di confronto ha riguardato il tracciato planimetrico e la quota del ferro. Nel corso di numerosi incontri, verifiche e fasi di valutazione tecnica, vengono studiate alternative di progetto, scartate tutte le ipotesi di tratti in trincea e a raso, scelta la sola realizzazione in galleria che partendo da Campegna prosegue lungo il Parco dello sport, raggiunge Acciaieria, Città della Scienza e Porta del Parco servendo di fatto i punti nodali dell’area. Tra i tanti, due aspetti ingegneristici sono affrontati nel corso del progetto: la fornitura di energia elettrica e di acqua per la metropolitana, le interferenze del tracciato con grossi collettori fognari presenti nella zona. A raso, invece di rilievo l’integrazione architettonico-paesaggistica delle

  5. Il valore del territorio, non il prezzo

    Directory of Open Access Journals (Sweden)

    Daniela Cavallo

    2016-01-01

    Full Text Available The value of the territory, not the price, as a place to live, including tools urban planning and landscape protection. A proposal, the guide / head-up plan, for the exploitation of a territory, about de-centering sew up. It should be noted that it is not used sata a disciplinary perspective “management” rather of Architecture and Regional Planning, these contaminated by a vision that seeks for some years now to borrow the thought of doing business within the design of the area in a contamination that is good, that can bring ideas to solve the problems of exploitation of territories that too often seek theoretical solutions for acting watertight compartments. The heritage of which we are heirs have all those variables that are the definition of Territory architect Alberto Magnaghi, definition often used by those who do Local Marketing, as a starting point. Find the streets active and operative where contamination between different disciplines and has the parallel exercise obiettio of this paper, whereas managementi urban architecture, planning economy, restoration, tend all have a common goal to preserve value and to promote the area to improve the quality of life of its inhabitants, who are permanent or occasional.

  6. Video-testamento: come promuovere arte, teatro e territorio. Il caso di Gibellina / The video-testament: how to promote art, theatre and territory. The case of Gibellina

    Directory of Open Access Journals (Sweden)

    Valentina Garavaglia

    2016-05-01

    Full Text Available Trattare di Gibellina significa considerare il senso del tempo, della memoria e della loro azione sia sul presente che sul futuro, e porlo in relazione con la reazione dell’uomo di fronte al tema delle rovine o meglio a quello delle macerie del terremoto del 1968 che cancellò paesi interi della valle del Belice. Da allora, Gibellina, per risollevarsi dalla tragedia, ha attivato un intenso programma di ricostruzione, che ha visto come protagonisti l’arte e il teatro. L’esperienza teatrale di Gibellina rappresenta il modello di un teatro totalizzante, che il video ha solo provato a raccontare, perché è solo lo spettatore, il turista, il visitatore partecipe e attivo che può comprendere la misura di uno spettacolo dove è l’essere umano coinvolto da un evento naturale, che fa da prologo e da epilogo a ogni rappresentazione. Quiproquo, il film documentario di Elisabetta Sgarbi, svela un’Italia piena di contraddizioni sconosciuta agli italiani stessi.   We cannot speak of Gibellina without addressing the idea of time, of memory and of their effects on the present and the future, of its relation to man confronted with ruins. More precisely, with the ruins left by the earthquake that struck the towns that had for centuries stood in the Belice Valley during the night between January 14 and 15, 1968. Since that time, to get back on its feet, Gibellina has engaged in an intensive process of reconstruction, with art and theater as leading players. The Gibellina theater experience is an example of total theater, which the video merely tries to describe, because only a spectator, a tourist, an active and participating visitor can fully comprehend the scope of a show in which the person is drawn in by a natural event, which serves as prologue and epilogue of each performance. Quiproquo, the documentary by Elisabetta Sgarbi, reveals an Italy full of contradictions Italians themselves are unaware of.

  7. Geomatic City Sensing, città, reti, sensori e tempo reale. Tecnologie e approcci innovativi per conoscere e governare il territorio

    Directory of Open Access Journals (Sweden)

    Giovanni Borga

    2012-04-01

    Full Text Available Come si può governare senza conoscere? La soluzione delle problematiche territoriali mediante decisioni eazioni specifiche non può prescindere dalla comprensione di oggetti, fenomeni, correlazioni e dinamiche checi forniscono gli elementi necessari a definire una strategia e, com’è noto, più il contesto è articolato e più è difficile conoscere e capire.   Geomatic City Sensing, city, networks,  sensors and real-time. Technologies  and  innovative  ap-proaches to understand and gov-ern the territoryHow can you govern without knowing? The solution of territorial issues by means of specific decisions and actions cannot be  separated  from  an  understanding of  objects,  phenomena,  and  dynamic correlations  that  provide  the  elements necessary  to  define  a  strategy  and,  of course, the context is more complex and more difficult to know and understand.

  8. Geomatic City Sensing, città, reti, sensori e tempo reale. Tecnologie e approcci innovativi per conoscere e governare il territorio

    Directory of Open Access Journals (Sweden)

    Giovanni Borga

    2012-04-01

    Full Text Available Come si può governare senza conoscere? La soluzione delle problematiche territoriali mediante decisioni eazioni specifiche non può prescindere dalla comprensione di oggetti, fenomeni, correlazioni e dinamiche checi forniscono gli elementi necessari a definire una strategia e, com’è noto, più il contesto è articolato e più è difficile conoscere e capire. Geomatic City Sensing, city, networks,  sensors and real-time. Technologies  and  innovative  ap-proaches to understand and gov-ern the territoryHow can you govern without knowing? The solution of territorial issues by means of specific decisions and actions cannot be  separated  from  an  understanding of  objects,  phenomena,  and  dynamic correlations  that  provide  the  elements necessary  to  define  a  strategy  and,  of course, the context is more complex and more difficult to know and understand.

  9. Territorio, educacion y multiculturalidad

    OpenAIRE

    Molina Andrade, Adela; Rodriguez Pizzinato, Liliana Angélica

    2012-01-01

    La ponencia presenta las líneas iniciales que orientan la inquietud investigativa como parte del proceso de formación doctoral que comienza, pensando en la relación de las concepciones de los maestros en formación en particular sobre el territorio y su incidencia en las prácticas pedagógicas, como una posibilidad de reflexionar sobre estas y los efectos que tienen en la construcción de territorios epistémicos, configurados a partir de las diversas formas de relación con el conocimiento que es...

  10. Tecnologie e dati spaziali per una moderna governance del territorio Strumenti a supporto per una riforma del catasto

    Directory of Open Access Journals (Sweden)

    a cura della redazione MediaGEO

    2013-12-01

    Full Text Available This article outlines the methods and activities of the sector mapping in support of the important process of renewal of the entirecadastral system. Describes the modern technologies and spatialdata available today that can assist in setting up complex issues of reforming the system of quantities cadastral and, more generally, in the processes for the fight against tax evasion in real estate.

  11. La Lavagna Interattiva Multimediale a supporto degli studenti disabili e con DSA all’Università di Modena e Reggio Emilia

    Directory of Open Access Journals (Sweden)

    Giacomo Guaraldi

    2013-03-01

    Full Text Available Negli ultimi anni l’introduzione delle moderne tecnologie ha consentito agli studenti con disabilità di raggiungere un maggior grado di autonomia e ha favorito un mutamento nella didattica che è diventata sempre più una «didattica inclusiva», incentrata sui bisogni educativi speciali di tali soggetti e soprattutto sulle potenzialità nascoste in essi. I software per l’apprendimento, le sintesi vocali, le lavagne interattive multimediali (LIM, i netbook, i tablets, gli Ipad creano una «rete integrata» che permette, grazie a linguaggi diversi e multimodali, di accrescere l’autostima dei soggetti con disabilità e favorire la loro autonomia. La lavagna è uno strumento che stimola l’apprendimento, in quanto utilizza un linguaggio più vicino alla modalità comunicativa delle nuove generazioni, riducendo così la distanza docente e discente. Questo è tanto più importante nel caso di studenti con disabilità o con disturbo specifico dell’apprendimento: il disabile sensoriale può utilizzare la modalità comunicativa residua, il disabile motorio può «sfogliare» un testo, farselo leggere, prendere appunti, il ragazzo con DSA può usufruire della sintesi vocale per la lettura e/o per il supporto alla scrittura.

  12. Tecnologie innovative a supporto della gestione della sicurezza nei cantieri

    Directory of Open Access Journals (Sweden)

    Berardo Naticchia

    2013-10-01

    Full Text Available Il conseguimento di elevati livelli di sicurezza in cantiere è influenzato dalle decisioni assunte in fase di programmazione. Permangono tuttavia i pericoli generati dalla concomitanza di fattori impredicibili, che possono essere mitigati dall’adozione di sistemi di monitoraggio automatico. Questo contributo presenterà tre sistemi: un sistema proattivo adatto a prevenire rischi di caduta di materiali dall’alto; un sistema di monitoraggio in tempo reale a bassa infrastrutturazione per segnalare interferenze pericolose tra le squadre; un sistema di controllo in tempo reale della concentrazione di particolato fi ne. Tutti questi sistemi adottano tecnologie avanzate e implementano logiche per valutare il livello di rischio contingente. Si mostra perciò come l’impiego di tecnologie ICT può supportare la gestione della sicurezza.

  13. «Ingannare l’occhio» o presentare lo sguardo? Il trompe-l’œil attraverso i collages cubisti

    Directory of Open Access Journals (Sweden)

    Francesca Polacci

    2012-12-01

    Full Text Available Questo saggio si propone di mostrare il ruolo svolto dal trompe-l’œil in seno alla produzione cubista di Picasso. Cercheremo di metterne in luce il ruolo centrale sia nell’articolazione degli spazi della rappresentazione sia per la realizzazione del primo collage. Sarà centrale la relazione tra mimesi e trompe-l’œil laddove sul supporto è iscritto un frammento di tela cerata, come nel primo collage, ma proveremo altresì a mostrare, passando attraverso le analisi, come il collage sia anche un’operazione teorica, che si fonda su di una discontinuità di ordine plastico (cromatico, tattile, etc..

  14. Dinamiche di Trasformazione del Territorio dell'Isola di Capri: fonti, problemi e dibattito tra XIX e XX secolo

    OpenAIRE

    Malfi, Marco

    2017-01-01

    IL lavoro mira all'analisi e all'interpretazione delle trasformazioni del territorio di Capri tra Ottocento e Novecento, attraverso l'uso di fonti archivistiche inedite relative alla vicenda demaniale dell'isola.

  15. Biodiversidad, cultura y territorio

    Directory of Open Access Journals (Sweden)

    Evelinda Santiago

    2007-01-01

    Full Text Available Después de una destrucción sistemática de la naturaleza durante varios decenios, el discurso de la biodiversidad es la réplica de lo que podría llamarse "la irrupción de lo biológico"; esto es, la supervivencia de lo biótico como problema central del orden moderno; en este sentido, el discurso de la biodiversidad se declara garante para salvar a la naturaleza de las prácticas destructoras y solvente para instituir en su lugar una cultura de la conservación. Sin embargo, el discurso aún tiene vacíos que se ha pretendido llenar a través de debates que últimamente han versado sobre la importancia que tiene el conocimiento local, las formas de vida -usos y costumbres- y la producción tradicional, dentro del andamiaje que soporta el significado de la biodiversidad. Por una parte, para los gobiernos de los países industrializados y las instituciones gubernamentales internacionales el conocimiento tradicional es un bien de la humanidad que cuando es mejorado se convierte en una innovación tecnológica susceptible de ser patentada y fi nalmente comercializada, sin que los dueños del conocimiento base se beneficien en ningún momento. Por otro lado, para campesinos, intelectuales y activistas el conocimiento local, las formas de vida y la producción tradicional son la base para reconstruir el territorio de campesinos e indígenas, para fortalecer la cierta autonomía y autosuficiencia en la que viven; pero con su participación activa en la defi nición de todo aquello que les impacte. A partir de estas reflexiones se están construyendo espacios que den respuesta a la privatización, respuesta fundamentada en el concepto de "lo comunal" (Grain, 2005.

  16. Relaciones entre patrimonio y territorio

    Directory of Open Access Journals (Sweden)

    Horacio Torrent Schneider

    2006-05-01

    Esta condición del patrimonio también puede surgir de una intervención que pretendidamente haya asumido ambas escalas. Es decir que la acción sobre el territorio rural y urbano pueda ser entendida desde un punto de vista arquitectónico. Este ha sido el caso del Plan Serena. 

  17. Governo del territorio e grandi trasformazioni nella regione urbana milanese

    Directory of Open Access Journals (Sweden)

    Fulvia Pinto

    2010-02-01

    Full Text Available  Lo studio analizza le grandi trasformazioni in atto nella “regione urbana” milanese, esaminando gli strumenti, le strategie e le politiche seguite. Per “regione urbana” si intende un territorio che non fa riferimento a relazioni gerarchiche di tipo centro-periferico, bensì determina relazioni multi direzionali, a differenza dell’area metropolitana che viene definita in base a relazioni di dipendenza (economica, sociale, funzionale, ecc. di agglomerati esterni rispetto ad un capoluogo. La regione urbana milanese è uno dei poli economici e produttivi più attivi a livello nazionale ed europeo, tuttavia tale territorio è caratterizzato da una ridotta qualità urbana e ambientale e da fenomeni di polarizzazione e di frammentazione sociale in aumento, che hanno ripercussioni negative sulle prospettive di sviluppo dell'area. I più recenti strumenti di pianificazione dell’area milanese fanno riferimento alla coesione territoriale, cercando di disegnare una nuova struttura per il territorio frammentato e diffuso, consolidando il policentrismo della regione urbana, favorendo il riconoscimento di aggregazioni intermedie, al cui interno ricercare integrazione del sistema dei servizi, identità e appartenenze di area. Per attivare una politica di riqualificazione a livello urbano e territoriale, risulta fondamentale seguire forme di coordinamento tra i vari livelli di pianificazione. Particolare attenzione viene posta al problema della mobilità che richiede strategie particolari non solo del traffico quale effetto indotto, ma anche delle cause che lo producono, con riferimento specifico alla distribuzione sul territorio delle diverse attività, ad un corretto equilibrio tra insediamenti residenziali, produttivi e terziari. È necessario, dunque, individuare strumenti e procedure, capaci di perseguire un equilibrio dinamico tra i flussi attratti dalle attività insediate e i flussi “sostenibili” dalle infrastrutture di trasporto

  18. Il progetto SISTER per il comune di Lignano Sabbiadoro

    Directory of Open Access Journals (Sweden)

    Alberto Poli

    2005-10-01

    Bonelli ha presentato il progetto sperimentale di sistema informatico per la gestione del territorio, che è in corso da circa un anno. Ecco la sintesi della relazione del Sistema Informativo Integrato Territoriale (SISTER realizzato da Politecnica.

  19. Decision making information systems and data base management; Applicazioni dei sistemi di supporto alle decisioni manageriali in un ente fortemente decentrato. Sviluppo di un prototipo per la valutazione di nuovi progetti

    Energy Technology Data Exchange (ETDEWEB)

    Minelle, F. [Rome, Univ. `La Sapienza` (Italy). Fac. di Scienze Matematiche, Fisiche e Naturali; Di Marco, R.A. [ENEA, Rome (Italy). Funzione Centrale Informatica; Belli, A.

    1997-01-01

    In these years Information Technology has been used in activities that require an intelligent intervention. In this context take placing Decision Support Systems, since they use Information Technology to support users in decision processes, that is problems of logical level greater then problems normally treated by traditional information systems. The purpose of this work is to describe Decision Support Systems specifying what they are, their functionally and structure, identifying, furthermore, user types referred to and interaction modality between them; and to present a prototype of these systems. From a preliminary analyses phase of ENEA being and its Information Systems to understand which topics can be supported by systems of this type, it deals with one of these topics: weighing of new project, finding parameters, or key quantity, that affect and determine decisions. It describes, then, models, conceived form parameters, that permit to the user, through a simple representation of results, to evaluates advantages and disadvantages of a new project. From models, analyses of data necessary to models and from requisites of simplicity and use fullness of user interface, it has been carried out a prototype. For this purpose it has been followed the Sprague and Carlson model that provides a data base, a Model Base and a Software System. [Italiano] In questi anni si sta assistendo ad un utilizzo dell`informatica in attivita` che richiedono un intervento `intelligente`. In tale contesto si collocano i Sistemi di Supporto alle Decisioni, poiche` utilizzano le tecnologie informatiche per supportare l`utente in processi decisionali, quindi problemi di livello logico piu` elevato di quelli trattati dai tradizionali sistemi informativi. Il presente lavoro ha lo scopo di descrivere i Sistemi di Supporto alle Decisioni specificando cosa sono, le loro funzionalita` e la loro struttura, individuando, inoltre, i tipi di utenti a cui sono rivolti e le modalita` di interazione

  20. Il progetto di ricerca BLU-ARCHEOSYS: tecnologie innovative e sistemi avanzati di supporto per l’archeologia subacquea

    Directory of Open Access Journals (Sweden)

    Lucio Colizzi

    2014-02-01

    Full Text Available In this article we summarize the main findings of the research project, BLU- ARCHEOSYS. It ranges from results achieved in the support systems of the human operations carried out directly in the underwater world, such as vision systems for 3D reconstruction of the seabed, multicomponent and innovative configuration ROV platforms. Ample space is given to software systems for data virtualization, and numerical simulation applied to the design of interventions for the recovery of shipwrecks. Important results have been achieved in the analysis of underwater findings, where interesting results have been obtained in the use of particle accelerators and morphological characterization of new varieties. Lastly, mention is made of the survey methodology designed specifically to orchestrate the great variety and quantity of knowledge made available by the project partners.

  1. Il progetto SISTER per il comune di Lignano Sabbiadoro

    OpenAIRE

    Alberto Poli

    2005-01-01

    Il comune di Lignano è stato recentemente invitato a Roma in qualità di relatore alla conferenza nazionale dei sistemi informativi territoriali organizzata da Esri, il maggior produttore mondiale di software per la gestione delle cartografie informatizzate. In tale occasione l’assessore AngeloBonelli ha presentato il progetto sperimentale di sistema informatico per la gestione del territorio, che è in corso da circa un anno. Ecco la sintesi della relazione del Sistema Informativo Integrato Te...

  2. Il progetto SISTER per il comune di Lignano Sabbiadoro

    Directory of Open Access Journals (Sweden)

    Alberto Poli

    2005-10-01

    Full Text Available Il comune di Lignano è stato recentemente invitato a Roma in qualità di relatore alla conferenza nazionale dei sistemi informativi territoriali organizzata da Esri, il maggior produttore mondiale di software per la gestione delle cartografie informatizzate. In tale occasione l’assessore AngeloBonelli ha presentato il progetto sperimentale di sistema informatico per la gestione del territorio, che è in corso da circa un anno. Ecco la sintesi della relazione del Sistema Informativo Integrato Territoriale (SISTER realizzato da Politecnica.

  3. Territorio e logistica: un binomio ancora tutto da inventare

    Directory of Open Access Journals (Sweden)

    Alessandro Bove

    2008-12-01

    Full Text Available La velocità di adattamento alle situazioni è quel concetto che sta alla base del nuovo modo di fare e vivere il territorio. Esso accomuna sia gli aspetti di urgenza legati all’esigenza di trasformazione delle strutture territoriali per far sì che esse possano confrontarsi in maniera competitiva con territori che sempre di più devono aggiornare la propria immagine ed organizzazione per far fronte ai nuovi dettami e strategie imposti dalla globalizzazione, sia gli aspetti più strettamente economici e della produzione i quali, nelle sfide lanciate dalla mondializzazione dei mercati e dall’impellenza della sostenibilità - intesa nella sua accezione più ampia - risentono in maniera sempre più pressante della necessità di un aggiornamento o di una trasformazione continui.

  4. Estructura de Información Geográfica Vulnerabilidad del Territorio

    OpenAIRE

    Narvaez, Nixon

    2012-01-01

    Estructura de Información geográfica Vulnerabilidad del Territorio temas: Estructura del territorio, Enfoques de la estructura del territorio, Grado de exposición del territorio y Vulnerabilidad de los elementos estratégicos

  5. Triage e regole di supporto della decisione clinica nel paziente politraumatizzato veterinario

    OpenAIRE

    Foglia, Armando

    2017-01-01

    Il trauma è spesso causa di lesioni anche mortali nel cane e nel gatto. Numerosi sono i fattori in grado di influenzare la sopravvivenza e in medicina umana, diversamente dalla medicina veterinaria, sono disponibili numerosi sistemi di valutazione del paziente politraumatizzato. Questi permettono di determinare la necessità di trattamenti specialistici ed identificare i pazienti ad alto rischio di complicazioni o morte. Tali informazioni potrebbero essere utili anche per il paziente veterinar...

  6. Waterway e sviluppo del territorio: nuova mobilità e turismo sostenibile

    Directory of Open Access Journals (Sweden)

    Oriana Giovinazzi

    2010-10-01

    Full Text Available Spesso origine dei primi insediamenti urbani, i corsi d’acqua sono stati nei secoli fonte di sostentamento per le popolazioni e strumento di scambio tra genti e culture. Proprio per il loro scorrere attraverso il territorio, essi sono per definizione luoghi di relazione, di intersezione tra diverse realtà urbane dove si incontrano ambiente, architettura, pianificazione, trasporti ma anche arte, cultura e turismo. Per questa loro caratteristica, le vie d’acqua rappresentano una grande potenzialità per lo sviluppo del territorio sia in termini di mobilità – di merci e di persone - che di turismo sostenibile. La loro riqualificazione permette di recuperare il ruolo di spazio pubblico e di paesaggio rurale, urbano e turistico di qualità; luoghi di fruizione turistica, culturale, gastronomica e sportiva, quindi di qualità della vita. Dopo decenni di oblio, sollecitata dal rinnovato interesse verso questi assi e anche dalle direttive dell’Unione Europee, l’Italia e, in particolare il Nord del paese, muove i primi passi verso la valorizzazione delle waterway a fini turistico-culturali, aprendo nuove possibilità di sviluppo del territorio. Sia pur con ritardo rispetto ad altri Paesi, che da anni e in diverse forme valorizzano e “sfruttano” le vie d’acqua, si avverte anche in Italia un cambio di mentalità che vede nell’uso e nel recupero di tale risorsa uno strumento importante per garantire la sostenibilità ambientale ed economica e il recupero di una identità culturale quasi dimenticata.

  7. Il territorio come un presepio: il paesaggio agrario nei Voyages de Naples tra Sette e Ottocento

    Directory of Open Access Journals (Sweden)

    Ilaria Agostini

    2015-11-01

    Full Text Available The voyage de Naples made a name for itself in the second half of the eighteenth century: tourists are attracted by the new archeological discoveries and the richness of its natural resources. The accounts of the journey and guides focus their attention on these themes and dedicate several pages to natural and historical monuments. The background is the rural landscape, constantly present, but never playing a leading role. The landscape of the countryside of Aversa is an exception: where the method of training vines onto poplars by mean of tall shoots takes on such proportions that the guidebooks cannot fail to mention them. The french odeporic literature deals with rural landscape in a multi-faceted manner. It is possible, however, to find a common stance in the appreciation of those landscapes which present strong geophysical features, well-cultivated countryside, great monumental value and the intense liveliness of the local population: territories where these elements appear to have been artistically arranged. 

  8. Arquitectura y territorio rural. Territorio, materia y memoria: aportaciones desde la arqueología del paisaje

    OpenAIRE

    Criado-Boado, Felipe; Villa-Indurain, Iñaki; Vuelta-Santín, Rubén; Valladares Durán, José

    2016-01-01

    [ES] Conferencia de Felipe Criado-Boado, titulada "Territorio, materia y memoria: aportaciones desde la arqueología del paisaje", en el evento "Arquitectura y territorio rural" organizado por rvr arquitectos y la Fundación María Martínez Otero, en Callobre, A Estrada.

  9. Cuerpos, Territorios y Población

    Directory of Open Access Journals (Sweden)

    Patricia Alejandra Collado

    2010-12-01

    Full Text Available Este libro es fruto de las experiencias de diferentes equipos de investigación y líneas de pesquisa que de la mano de Adrián Scribano y Eugenia Boito abrevaron en el Programa de Estudios Sobre Acción Colectiva y Conflicto Social del Centro de Estudios Avanzados de la Universidad de Córdoba. En esta oportunidad su producción colectiva hace énfasis en las transformaciones acaecidas en la vida de los sujetos –producto de la neocolonialidad del capital- y pone como centro la reflexión sobre sus implicancias en tanto marcas expuestas en el cuerpo, el territorio y la población de las ciudades de Córdoba y Villa María.

  10. Il turismo è un fenomeno spaziale

    Directory of Open Access Journals (Sweden)

    Pasquale Boccagna

    2010-10-01

    Full Text Available Il turismo e le attività da esso generate si combinano con il fattore territoriale dando luogo al processo di fruizione del servizio turistico caratterizzato essenzialmente dalla contestualità dell’erogazione e del consumo di un’entità in buona parte immateriale in un contesto geografico scelto dal consumatore e definito destinazione turistica. Se la chiarificazione del concetto di turismo e di prodotto turistico è risultata essenziale per spiegare in un certo senso le ragioni dell’offerta (perché nascono e si sviluppano le attività turistiche?, altrettanto significativa sembra l’opportunità di enucleare, tra le varie definizioni che sono state proposte nella letteratura specialistica, gli elementi caratteristici della destinazione turistica per arrivare alla spiegazione delle ragioni del management del sistema di offerta (prodotto complesso e globale. Le domande di fondo sono: Cosa spinge i turisti a partire dal luogo di abituale dimora per recarsi in una località che presenta caratteristiche naturali, ambientali e culturali completamente diverse dalla regione di partenza? Cosa fa trasformare un territorio in una destinazione? Perché alcuni flussi turistici prediligono determinate destinazioni rispetto alle altre? Quale è l’impatto sul piano della mobilità territoriale ed urbana? Il sistema dei trasporti può essere considerato una risorsa generatrice di vantaggi competitivi per una destinazione turistica? Il framework dell’articolo è rappresentato dalla teoria marshalliana del distretto industriale che pone il territorio e le sue risorse alla base dello sviluppo del sistema locale. Ad esso si tenta di sovrapporre il framework VRIO (Valore, Rarità, Inimitabilità, Organizzazione, derivato dalla Resource Based View, per stabilire se una determinata risorsa del territorio, nel caso di specie il sistemi di trasporto urbano ed extraurbano, può generare un vantaggio competitivo sostenibile e duraturo. Per l’analisi delle

  11. Crowdfunding per il Patrimonio Culturale nei Centri Storici Minori: la Chiesa di San Michele a Savoca

    Directory of Open Access Journals (Sweden)

    Antonino Cosentino

    2016-08-01

    Full Text Available Questo articolo illustra la campagna di crowdfunding “Save the Soul of Savoca” per finanziare il restauro di un ciclo di dipinti settecenteschi nel piccolo borgo di Savoca (ME. Si presenta questa iniziativa come un modello per la salvaguardia del patrimonio culturale del nostro Paese che è vastissimo, distribuito su numerose piccole realtà locali e spesso non adeguatamente tutelato. Il finanziamento erogato dallo Stato e dagli enti locali rappresenta, ancora oggi, la fonte di sostentamento principale per le iniziative che coinvolgono il settore dei beni culturali. Tuttavia, l’attuale congiuntura economica ha favorito la nascita e la diffusione di strumenti e modalità di finanziamento alternativi attraverso i quali poter supportare il restauro del nostro Patrimonio Culturale. Il crowdfunding è il metodo che più si sta diffondendo ed è una forma di microfinanziamento dal basso finalizzato alla creazione e al supporto di un processo collaborativo tra singoli soggetti che utilizzano il proprio denaro per sostenere iniziative di singoli individui o di organizzazioni più strutturate. Molteplici sono gli esempi attuali di impiego del crowdfunding, da parte di associazioni e comitati, per il restauro di monumenti di interesse nazionale.

  12. Grand Tour: immaginario, territorio e culture digitali

    Directory of Open Access Journals (Sweden)

    Emiliano Ilardi

    2016-12-01

    Full Text Available Il Grand Tour può essere recuperato come asset narrativo utile per un intervento strategico di re-branding del viaggio in Italia? Il contributo analizza il contesto e le condizioni per una progettazione di questo livello nell’ambiente culturale dell’epoca digitale. Considerando gli archetipi moderni della mediazione dei luoghi come una grande riserva di senso, da riattivare sia nelle pratiche basate sui format seriali e transmediali che valorizzano i territori nella produzione creativa, sia nella costruzione di infrastrutture digitali e  transluoghi per la valorizzazione degli attrattori culturali.

  13. Santo Domingo Savio: un territorio reterritorializado

    Directory of Open Access Journals (Sweden)

    Jorge Ivu00E1n Ballesteros Toro

    2010-01-01

    Full Text Available Santo Domingo Savio es un barrio de la Comuna Popular número 1,1 ubicado en el nororiente de la ciudad de Medellín (Antioquia, Colombia. Es un territorio formado a través de la ocupación marginal e ilegal de la tierra, que ha sido marcado por la violencia y la pobreza. El Estado, luego de años de abandono, ha implementado proyectos de desarrollo urbano que han generado infraestructura de transporte, espacio público y educación; proyectos que enmarcan la ciudad en el contexto de la competitividad. La actual dinámica territorial ha convertido esta comuna en un lugar atractivo para residentes y turistas, en un espacio reterritorializado por el Estado; además, ha transformado el lugar en un laboratorio de ciudad y en un modelo de renovación. Bajo este escenario, esta exploración pretende visualizar la territorialidad que en el transcurso del tiempo han tenido los diferentes actores en este espacio.

  14. Il laser

    CERN Document Server

    Smith, William V

    1974-01-01

    Verso il 1960, il laser era ancora "una soluzione alla ricerca di un problema", ma fin dagli anni immediatamente successivi si è rivelato uno strumento insostituibile per le applicazioni più svariate.

  15. EL PAISAJE COMO "PEDAGOGÍA DEL TERRITORIO"

    Directory of Open Access Journals (Sweden)

    Joan Luisa de Tort

    2004-12-01

    Full Text Available Resumen:Concepto clave de la geografia moderna, el  paisaje puede constituir, por su versatilidad y por su vocación integradora, una herramienta de primer orden para el estudio y el conocimiento geográfico. En este artículo exploramos algunas de las posibilidades que ofrece de cara a lo que hemos denominado unapedagogia del territorio. A tal fin hacemos en primer lugar unas consideraciones i teóricas, que nos permiten establecer que el paisaje, en su origen, es un concepto de raíz inequívocamente unitaria. En segundo lugar,  y situados ya en un nivel práctico, proponemos una utilización del paisaje como "forma de aproximación" a la diversidad geográfica de Cataluña. Por último, dentro de una escala de mayor detalle, y en el marco especifico de la región de L'Emporda (Girona, formulamos un esquema básico para el estudio del paisaje tomando los nombres de lugar, o topónimos, como referente geográfico fundamental.Palabras clave: Paisaje, territorio, léxico geográfico, etimología, Cataluña, Emporda.Abstract: A key concept in modm geography, the landscape is, because of its versatility and its integrative nature, and ideal tool with which to study the territory. This article explores the possibilities of using the landscape in what we cal1 the "pedagogy of temtory". After the consideration of different theoretical questions, the exploration is conducted at a douhle level: at a general scale, which here corresponds to that of Catalonia, and at a specifically local scale, which corresponds to the  comarca of Emporda (Girona, from the point of view of its toponymy.KEY WORDS: Landscape, land, toponjmy, etymology, Catalonia, Emporda.RÉSUMÉ:Concept clé de la géographie modeme, le paysage est pour sa versatilité et pour sa vocation intégrante un outil convenable pour I'étude du temtoire. Dans cet article nous explorons les possihilités qu'il ofie face a ce que nous appelons 'pédagogie du temtoire'. Aprks quelques consid

  16. Uso de endoprótesis en el tratamiento de lesiones no oclusivas del territorio iliaco Uso de endoprótese no tratamento de lesões não-oclusivas do território ilíaco

    Directory of Open Access Journals (Sweden)

    Renato Mertens

    2006-06-01

    Full Text Available OBJETIVO: La cirugía endovascular se ha establecido como una opción eficaz en el tratamiento de la enfermedad oclusiva ateroesclerótica de las arterias iliacas. Sin embargo, el uso de estos procedimientos para tratar otro tipo de lesiones aún no ha sido bien estudiado. Nuestro objetivo es analizar indicaciones y resultados del uso de endoprótesis en lesiones iliacas no oclusivas. MATERIAL Y MÉTODOS: Revisamos retrospectivamente los registros de 14 pacientes consecutivos, todos hombres, 61,6 años de edad en promedio (rango: 25-80 tratados por vía endovascular entre 2001 y 2006 por lesiones iliacas no oclusivas. El estudio pre y postoperatorio incluyó tomografía computada. El procedimiento se efectuó en quirófano, utilizando un angiógrafo digital. Se usó acceso femoral insertando endoprótesis tubulares. RESULTADOS: En 11 pacientes se asoció embolización de arteria hipogástrica ipsilateral. Las patologías tratadas fueron: ocho aneurismas ateroescleróticos, 3 disecciones, 2 lesiones traumáticas y un pseudoaneurisma anastomótico. La co-morbilidad más frecuente fue la hipertensión en 43% de los casos. No hubo mortalidad operatoria. Un paciente presentó un pseudoaneurisma femoral tratado con compresión. Un paciente tratado por fístula arteriovenosa traumática a nivel iliaco resuelve su insuficiencia cardiaca, con persistencia asintomática de mínimo flujo. La estadía postoperatoria fue de 3 días (mediana. No se presentaron otras endofugas iniciales o tardías. Durante un seguimiento promedio de 20,5 meses (rango 1 a 49, un paciente fallece por cáncer y ninguno ha requerido procedimientos complementarios. CONCLUSIÓN: El tratamiento endovascular de lesiones iliacas mediante endoprótesis es seguro y permite un resultado durable en el manejo de un amplio espectro de patologías.OBJETIVO: A cirurgia endovascular se estabeleceu como opção eficaz no tratamento da doença oclusiva aterosclerótica das artérias il

  17. Il patrimonio scomodo del Novecento europeo nel progetto Atrium a Forlì

    Directory of Open Access Journals (Sweden)

    Elena Pirazzoli

    2013-09-01

    Full Text Available Il Novecento ha lasciato tracce difficili nelle città d'Europa. I regimi che si sono succeduti hanno trasformato urbanisticamente e architettonicamente l'intero territorio e oggi è complesso relazionarsi con questi segni. Il progetto europeo Atrium - Architecture of Totalitarian Regimes in Urban Managements si propone di valorizzare, con attenta cura e senza intenti mistificatori, proprio il “patrimonio scomodo” di 11 paesi dell'Europa del sud.

  18. Scuola sul territorio: la testa nelle nuvole e i piedi ben piantati per terra

    Directory of Open Access Journals (Sweden)

    Angelo Bardini

    2013-12-01

    Full Text Available L’Istituto Comprensivo di Cadeo e Pontenure, in provincia di Piacenza, porta avanti un’idea di scuola quale comunità inclusiva che costruisce, in accordo e in stretta collaborazione con le agenzie del territorio, progetti di sperimentazione didattica attraverso una riorganizzazione degli spazi e dei tempi di apprendimento e sfruttando le potenzialità offerte dalle nuove tecnologie (LIM, ipad. Ambienti rinnovati, spazi aperti, tempo scuola lungo, nuove metodologie didattiche: il tutto per dare ad ogni singolo alunno la possibilità di imparare in modo personale e soggettivo, proponendo a tal fine momenti di cooperazione e di individualizzazione, di attività laboratoriali e di tutoraggio. Una Scuola2.0 per affrontare in modo diverso e nuovo l’arte di insegnare, con l’attenzione sempre puntata sul soggetto in apprendimento che si muove in una realtà sociale in mutamento costante.

  19. Edifici di culto e loro pertinenze, consumo del territorio e spending review

    Directory of Open Access Journals (Sweden)

    Federica Botti

    2014-09-01

    Full Text Available assegnista di ricerca nell'Università Alma Mater Studiorum di Bologna, Dipartimento di Scienze GiuridicheContributo sottoposto a valutazione SOMMARIO: 1. Crisi finanziaria dello Stato e nuovo ruolo e funzioni degli edifici di culto - 2. Configurazione degli spazi degli edifici di culto in relazione al loro uso pubblico - 3. Pertinenze “liturgiche” e pertinenze “funzionali”: un primo controllo di spesa - 4. Utilizzazione pubblica delle pertinenze, anche attraverso lo strumento delle convenzioni con gli enti pubblici. Gli edifici di culto di proprietà delle confessioni – 5. Gli edifici di culto di proprietà pubblica gestiti attraverso il F. E. C. -6. Le convenzioni per la concessione dell’utilizzazione a fini di culto di edifici di proprietà pubblica - 7. Il controllo di spesa e il patto di stabilità tra l’attuazione dell’art. 19 Cost., proprietà pubblica di edifici di culto, finanziamenti pubblici per la loro manutenzione/edificazione – 8. Spending review e rivisitazione del rapporto tra consumo del territorio, edifici esistenti e loro utilizzazione/fruizione.

  20. Un sistema di supporto alle decisioni per l’analisi dei conflitti derivanti dall’implementazione delle politiche di pricing

    Directory of Open Access Journals (Sweden)

    Mariano Gallo

    2012-01-01

    Full Text Available Negli ultimi anni molte città europee hanno introdotto politiche di tariffazione come strumento di gestione della domanda di trasporto, in particolare per ridurre la congestione e riequilibrare la ripartizione modale tra trasporto individuale e collettivo. Infatti, il comportamento degli utenti conduce il sistema ad una condizione di Equilibrio dell’Utente (User Equilibrium che non corrisponde alla massimizzazione dell’utilità globale e non prende in considerazione i costi esterni. Pertanto, al fine di raggiungere una configurazione efficiente nell’utilizzo dei sistemi di trasporto (indicata in letteratura come Equilibrio del Sistema – System Equilibrium, è necessario imporre una tariffazione sulle strade urbane in modo da massimizzare il surplus sociale. Per numerose ragioni (teoriche, politiche, sociali è impossibile applicare “tariffe efficienti” (indicate in letteratura come first-best solutions; perciò sulle reti reali bisogna applicare tariffe sub-ottimali (second-best solutions. Inoltre, una delle problematiche principali dell’applicazione delle politiche di pricing è la loro “accettazione” da parte della comunità e/o di sue componenti (commercianti, residenti, pendolari, ecc. che conduce a conflitti ed opposizioni.In questa nota, si analizza il problema del progetto delle tariffe ottimali nel caso in cui i ricavi siano investiti totalmente o parzialmente per migliorare il trasporto collettivo. In particolare, si formula un modello che sia multimodale e multiutente, in cui gli aspetti relativi alla scelta modale siano calcolati in maniera esplicita su rete in corrispondenza di ciascuna configurazione tariffaria. Il modello è applicato ad una rete test (costruita con differenti valori di accessibilità relativa tra le differenti zone, analizzando alcune strategie “second-best” con particolare riferimento al reinvestimento dei ricavi.

  1. Desigualdad, clase media y territorio en Chile: ¿clase media global o múltiples mesocracias según territorios?

    Directory of Open Access Journals (Sweden)

    Oscar Mac-Clure

    2014-09-01

    Full Text Available Se estudian las desigualdades entre territorios subnacionales según clases sociales en Chile, discutiendo si existe un único proceso de mesocratización. Para esto se analiza el proceso de urbanización, distinguiendo territorios de acuerdo con sus mercados de trabajo, donde diferentes clases medias habitan y desarrollan su actividad laboral. Se revisan definiciones de la clase media desde el punto de vista de los ingresos y de las ocupaciones, aplicándolas a esos territorios, argumentando que la clase media tiene características particulares según el territorio de que se trate.

  2. Il disegno gotico di San Giovanni Valdarno

    Directory of Open Access Journals (Sweden)

    Maria Teresa Bartoli

    2017-12-01

    Full Text Available San Giovanni Valdarno è una città del Valdarno di Sopra, il cui attuale centro storico fu la prima delle terre nuove della Repubblica Fiorentina, fondata alla fine del XIII secolo. Le vicende storiche della trasformazione del nucleo murato originario sono state oggetto di molti studi, ma la logica del suo particolare disegno non è stata molto investigata. L’approccio archeologico è quindi giustificato dal fatto che, per ciò che riguarda la forma del progetto urbano originario, gli studi finora pubblicati non vanno molto oltre la definizione di «progettazione ortogonale», data da David Friedman, suo maggiore studioso. I giudizi su di essa si sono quindi attestati sulla generica attribuzione di virtù e difetti che la tradizione storiografica annette alla città medievale, applicando formule basate su paradigmi convenzionali.Volendo condurre la ricerca di una descrizione significativa del tessuto materiale della città attingendo a paradigmi appartenenti al momento della sua realizzazione, è stato condotto uno studio metrico sulla forma della città storica, con riferimento al sistema del braccio fiorentino, considerato come parametro di riferimento fondamentale per la comprensione di un manufatto di dimensione urbana. L’aspetto archeologico della ricerca consiste quindi nella ricostruzione complessa di un paradigma dimenticato dall’attuale tradizione storiografica, alla luce del quale emergono negli oggetti storici significati e valori caduti dalla memoria trasmessa.L’analisi, condotta sulla planimetria digitale con il supporto di documenti storici del ‘200 e del ‘500, ha fatto emergere l’ordine logico e continuo del disegno geometrico della città fondata, replicabile a mente (e perciò memorabile, messo in opera nella pianta urbana, rendendo esplicita la sua logica e le sue connessioni sia con la cultura scientifica del tempo, sia con la tradizione storica precedente, risalendo a Vitruvio. Ai fini di interpretare

  3. La riduzione dell’impatto acustico dei parchi eolici sul territorio - The reduction of wind farms noise impact

    Directory of Open Access Journals (Sweden)

    Gianni Cesini

    2015-09-01

    Full Text Available L’energia eolica è oggi una delle fonti energetiche in più rapido sviluppo ma il rumore prodotto dalle turbine eoliche rappresenta uno dei maggiori ostacoli alla sua accettazione sul territorio. L’industria dell’eolico ha sviluppato soluzioni tecnologiche che rendono le turbine attuali meno rumorose, nonostante ciò il rumore prodotto e il prevedibile impatto sono criteri fondamentali per la localizzazione dei parchi eolici. Il presente lavoro passa in rassegna alcune soluzioni per ottenere riduzioni della rumorosità delle turbine dopo aver affrontato il problema di una valutazione previsionale dell’impatto acustico più rispondente a quella che sarà la situazione reale ad opera realizzata. ------ Wind power is nowadays one of the fastest growing energy sources but turbine noise is one of the major hindrances for the acceptance by the territories interested to the wind farms location. The industry has developed technological solutions that improve the efficiency and reduce the noise emissions of the wind turbines. Despite these improvements, the noise produced by wind farms is one the more critical criterion for their location. In this paper, we review some of the possible solutions for reducing the sound emissions of the turbines after facing the problem of a noise impact predictive assessment that better meet the actual acoustical conditions after the installation of the wind farm.

  4. territorio e identidad en seis artistas puertorriqueños

    OpenAIRE

    Ramos Collado, Lilliana

    2010-01-01

    El ensayo explora los conceptos de identidad y territorio a la luz de las teorías de “habitar” de M. Heidegger, de “radicante” de N. Bourriaud y de “desterritorialización” de G. Deleuze y F. Guatari en la obra de seis artistas puertorriqueños contemporáneos: Nora Rodríguez Valléés, Arnaldo Roche Rabell, Marxz Rosado, Vanessa Hernández Gracia, y el dúo Andrés Mignucci y María de Mater O’’Neill. Se propone que la identidad basada en la posesión de un territorio cierto se ha ido desv...

  5. La frontera invisible del territorio Wayúu

    OpenAIRE

    Giraldo, Eduardo

    2011-01-01

    El territorio del pueblo autóctono wayúu se sitúa, en la actualidad, en la frontera de Colombia y Venezuela. Las representaciones acerca de “la Gran Nación wayúu, dónde no existe la frontera” se encuentran en textos de la literatura sociológica y antropológica y también son expresadas por algunas personas de este pueblo. Pero la demarcación del límite geográfico tiene efectos reales sobre la movilidad y las percepciones dentro del territorio. Es así como, el presente artículo, busca mos...

  6. Fronteras en la construcción del territorio argentino

    Directory of Open Access Journals (Sweden)

    Alejandro Benedetti

    2014-01-01

    Full Text Available El presente ensayo reflexiona sobre las múltiples funciones que tuvieron las fronteras en la construcción del territorio argentino. En este se identifican diferentes momentos en el devenir histórico de la Argentina que llevaron a eliminar, mover, establecer o resignificar fronteras. Se pretende identificar, localizar y caracterizar tres arquetipos de fronteras y, en forma ulterior, analizar los elementos clave para una conceptualización.

  7. Comunidades y territorio en la costa del Ecuador

    OpenAIRE

    Guerrero Burgos, Rafael

    2012-01-01

    Se propone una definición teórica de la comunidad territorial sustentada en el concepto de identificación y la teoría del desarrollo rural territorial con el objeto de analizar las principales cadenas productivas que surcan la costa centro sur del Ecuador. Además se estudia a los principales movimientos agrarios que caracterizan un territorio que es sobre todo agrario y rural.

  8. Nuovi strumenti di Telerilevamento da satellite per il controllo del territorio

    Directory of Open Access Journals (Sweden)

    Michele Dussi

    2008-03-01

    Full Text Available New instruments for land management utilizing satellite remote sensingWe are at the beginning of a new Earth Observation age comprised of large amounts of data, high revisit times as well as high resolution images. All these characteristics were “dream-requirements” for E.O. operators in the past years. Today a new solution dubbed Cosmo-Skymed is being developed which will be operational in the coming months. Cosmo-Skymed is a dual-use end-to-end global data providing system. It makes use of an innovative constellation of 4 sun-synchronous satellites equipped with multimodal high-res synthetic aperture radar (SAR. It operates in X-band and is supported by a wide G/S infrastructure to meet high performance data acquisition and distribution service requirements. It is a made in Italy solution.

  9. Il Geoportale Nazionale del Ministero dell'ambiente e della Tutela del Territorio e del Mare

    Directory of Open Access Journals (Sweden)

    Salvatore Costabile

    2010-03-01

    Full Text Available MATTM National Geoportal The National Geoportal has been recently developed by the italian Department of the Environment and Land Protection (MATTM and represents an asnwer to all the issues connected to a growing need of Geographic Informations. The aim of an infrastructure like the one created by MATTM is to provide an affordable base for the future planning and managing of Italy’s land resources; the informations and metadata featured by the portal have been created with regard to the rules proposed by the INSPIRE Directive.

  10. Il Geoportale Nazionale del Ministero dell'ambiente e della Tutela del Territorio e del Mare

    Directory of Open Access Journals (Sweden)

    Salvatore Costabile

    2010-03-01

    Full Text Available MATTM National GeoportalThe National Geoportal has been recently developed by the italian Department of the Environment and Land Protection (MATTM and represents an asnwer to all the issues connected to a growing need of Geographic Informations. The aim of an infrastructure like the one created by MATTM is to provide an affordable base for the future planning and managing of Italy’s land resources; the informations and metadata featured by the portal have been created with regard to the rules proposed by the INSPIRE Directive.

  11. Cultivos ilícitos, territorios y drogas en Latinoamérica: Perspectivas comparativas

    Directory of Open Access Journals (Sweden)

    Salvador Maldonado Aranda

    2012-10-01

    Full Text Available O artigo analisa, diante de algumas experiências latino-americanas, como se constroem determinadas economias regionais da droga. Particularmente, como e em que sentido se transformam territórios “ilegais”, em que se estabelece o narcotráfico, de que maneira os Estados intervêm mediante políticas públicas e quais são suas consequências. Argumentaremos que parte dos problemas de cultivo, processamento e distribuição de drogas se relacionam com um complexo processo de intervenção/abandono do Estado de regiões formadas por dinâmicas de colonização direcionada ou forçada, deslocamentos violentos e orientados para o mercado agrícola de exportação. The article Illicit Crops, Territories and Drugs in Latin America: Comparative Perspectives reviews, in light of experiences in Latin America, how certain regional drug economies are built. In particular, how and in what sense there is a transformation of “illegal” territories where drugs trafficking is established; how the US intervenes through public policies and the consequences of such intervention. We shall argue that part of the problem of drug cultivation, manufacturing and distribution is related to a complex process of State intervention/abandonment of regions formed by directed or forced colonization dynamics; violent shifts directed at the agricultural export industry.Keywords: territories, illegal economies, illicit crops, drugs trafficking, Latin America

  12. Percorsi e terre di mezzo: dai cammini degli antenati ai luoghi dell'incontro e della festa contemporanei: il museo mater di Mamoiada

    OpenAIRE

    Decandia, Lidia

    2014-01-01

    Il saggio intende raccontare l’esperienza svolta insieme a Studio Azzurro nella progettazione del Museo di archeologia e del territorio di Mamoiada. In questa esperienza attraverso l’uso di strumenti multimediali e interattivi si è lavorato per costruire non un luogo contemplativo, ma una vera e propria centrale “centrale di produzione di conoscenza memoriale e immaginativa”. Nel raccontare alcuni aspetti della storia di questo territorio, per individuare una possibile chiave i...

  13. Innovación tecnológica y territorio

    Directory of Open Access Journals (Sweden)

    Chaparro Mendivelso Jeffer

    2003-01-01

    Full Text Available El término innovación nos remite a la idea de cambio hacia algo nuevo o mejor dentro de cierto marco de referencia. La innovación tecnológica involucra nuevos o mejores productos, procesos o servicios,y se aplica prácticamente a todas las áreas científicas. Pero todos los territorios no ofrecen las condiciones necesarias o adecuadas para que un medio innovador se desarrolle o sostenga adecuadamente. El medio innovador, como lugar donde se gesta la innovación, produce o influencia cambios que van desde el mercado laboral hasta la estructura del territorio que lo sustenta. La industria de alta tecnología está asociada al medio innovador porque sus productos son muy especializados, bastante diferentes a los que ofrece la industria tradicional. El medio innovador requiere de ciertas características que incluyen la cooperación con universidades y centros de investigación, la disponibilidad de infraestructuras de transporte y de telecomunicaciones, la fuerza laboral adecuada para cada una de las funciones, el capital o los recursos que permitan su sostenimiento, una línea de productos innovadores, el mercado para sus productos y la generación continua de sinergias. Por estas y otras razones la innovación tecnológica y el territorio están fuertemente ligados e imbricados, y muchas políticas de intervención territorial consideran pertinente incluir la potenciación de los medios innovadores y de la industria de alta tecnología.

  14. Cavilaciones sobre territorio, globalización e identidad

    OpenAIRE

    Ruth Helena Jaramillo

    2004-01-01

    Esta es una exposición sucinta de los planteamientos Renato ortiz en su libro Otro territorio en lo referente a la denominada, por él, modernidad-mundo; momento en el que se evidencian profundas transformaciones sociales producto del desarrollo de redes informáticas y comunicacionales que han ocasionado una evidente reconfiguración del espacio. Mutación que necesariamente hace que la aparente estaticidad de conceptos como Estado-Nación, identidad y cultura popular sea revisada y repensada por...

  15. CIUDADANIA Y TERRITORIO: VARIACIONES SOBRE EL CASO MEXICANO

    Directory of Open Access Journals (Sweden)

    Juan Manuel Ramírez S.

    1998-01-01

    Full Text Available El objetivo de este ensayo es precisar las implicaciones teóricas de la ciudadan ía y de su relación con el territorio. A partir del contenido de ambos conceptos, se analizan las vicisitudes del pasado inmediato y las búsquedas del presente, por parte de los mexicanos, para recuperar la dimensión territorial de su ciudadanía e incidir en la reordenación de su espacio nacional así como de los regionales y locales.

  16. Il monitoraggio delle emissioni di CO2 e dei consumi energetici a livello comunale tramite WebGis

    Directory of Open Access Journals (Sweden)

    Paolo Viskanic

    2012-04-01

    Full Text Available Il cambiamento climatico dovuto ai gas serra ed il progressivo esaurimento dei combustibili fossili hanno portatonegli ultimi anni ad un ripensamento delle politiche energetiche e ad una maggiore attenzione alle potenzialitàdi risparmio energetico e di abbattimento delle emissioni di CO2. Alla base di ogni strategia è fondamentale una base informativa dettagliata ed affidabile alla quale fare riferimento per studiare interventi e strategia. È in questo contesto che si colloca R3 EcoGIS, uno strumento WebGIS per il monitoraggio dei consumi e delle emissioni e per il supporto alle decisioni energetiche a livello comunale. A WebGis for the monitoring of CO2 emissions and energy consumption at the municipal levelClimate change from greenhouse gases and the progressiveexhaustion of fossil fuels in recent years have led to a rethinkingof energy policy and greater attention to the potential forsaving energy and reducing emissions of CO2. At the base ofeach strategy it is fundamental a detailed and reliable informationbase to which every study, interventions and strategies canbe referred. It is in this context that EcoGIS R3, a WebGIS toolfor monitoring fuel consumption and emissions and energysupport decisions at the municipal level.

  17. El territorio cultural en real de catorce-wirikuta

    Directory of Open Access Journals (Sweden)

    Guadalupe Salazar-González

    2014-10-01

    Full Text Available El presente trabajo expondrá el caso de la región Real de Catorce-Wirikuta, que incluye no sólo el poblado de dicho nombre (con población mestiza local y nacional, y extranjeros sino el territorio conocido como Wirikuta, que es la zona sagrada del pueblo indígena Wirrárika (conocido comúnmente como huicholes, además del entorno natural con fauna y flora endémica y otros asentamientos como son minas, socavones de minas, hacienda de beneficio minero, pueblos y rancherías, algunos habitados por población mestiza y otros abandonados. La idea es hacer la identificación del territorio, de su caracterización, funcionamiento y lo que le depara su futuro, pues actualmente está amenazado por: la explotación minera cielo abierto y el beneficio con cianuro (sistema metalúrgico; por el turismo “cultural peyotero” y religioso; por el tráfico de fauna silvestre; y por la llegada de pobladores de otras culturas. Las bases para ello están en la geografía, la historia de la apropiación del espacio geográfico por diversos grupos culturales e intereses y las prácticas sociales: su uso profano y sagrado; su uso cotidiano y cíclico; su significación y resignificación social; y el ejercicio del dominio territorial, la propiedad y la legislación que ahí opera. Todo lo cual manifiesta los diversos modos de vida, cosmovisión, usos y apropiación del territorio, y la relación con la naturaleza que cada cultura tiene, y por tanto entran en confrontación por el dominio del mismo espacio, pero sobre todo revela la incomprensión de el otro en todos esos aspectos.

  18. Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.

    Science.gov (United States)

    Neves, Fabiana; Abrantes, Joana; Almeida, Tereza; de Matos, Ana Lemos; Costa, Paulo P; Esteves, Pedro J

    2015-11-01

    ILs, as essential innate immune modulators, are involved in an array of biological processes. In the European rabbit (Oryctolagus cuniculus) IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18 have been implicated in inflammatory processes and in the immune response against rabbit hemorrhagic disease virus and myxoma virus infections. In this study we characterized these ILs in six Lagomorpha species (European rabbit, pygmy rabbit, two cottontail rabbit species, European brown hare and American pika). Overall, these ILs are conserved between lagomorphs, including in their exon/intron structure. Most differences were observed between leporids and American pika. Indeed, when comparing both, some relevant differences were observed in American pika, such as the location of the stop codon in IL-1α and IL-2, the existence of a different transcript in IL8 and the number of cysteine residues in IL-1β. Changes at N-glycosylation motifs were also detected in IL-1, IL-10, IL-12B and IL-15. IL-1α is the protein that presents the highest evolutionary distances, which is in contrast to IL-12A where the distances between lagomorphs are the lowest. For all these ILs, sequences of human and European rabbit are more closely related than between human and mouse or European rabbit and mouse. © The Author(s) 2015.

  19. Redes y territorio: la iniciativa IIRSA en foco

    Directory of Open Access Journals (Sweden)

    Roberto Chiarella Quinhoes

    2011-12-01

    ón de la Infraestructura Regional Sudamericana – IIRSA.La Visión Estratégica para la Integración Física Sudamericana (VESA se constituye en el enfoque principal de tal iniciativa, y la Metodología de Planificación Territorial Indicativa, en la herramienta metodológica central para implantar dicha visión y, así, desencadenar procesos de desarrollo sostenible en el territorio.Pretendemos desentrañar las relaciones entre el enfoque de la estrategia de desarrollo territorial brasileño y la VESA. Señalamos, además, algunos elementos que deberían ser puestos en consideración de manera que se perfeccione la herramienta metodológica. En tal sentido, partimos de la visión estratégica proponer un nuevo enfoque metodológico más integrador del territorio. Los elementos que unen un punto al otro pasan por el análisis de la propuesta metodológica en sí, de los ejes de integración y desarrollo, el estudio de las relaciones entre las redes y el territorio, así como por la evaluación de la necesidad de una propuesta de sistema urbano sudamericano.Consideramos que dicho sistema debería ser la base sobre la que se soporte toda la estructura del proceso de integración para el desarrollo sostenible del territorio sudamericano, que incluya los ejes IIRSA y las inversiones necesarias en los centros urbanos de la red, así como su jerarquización y funcionalidad.

  20. Cavilaciones sobre territorio, globalización e identidad

    Directory of Open Access Journals (Sweden)

    Ruth Helena Jaramillo

    2004-11-01

    Full Text Available Esta es una exposición sucinta de los planteamientos Renato ortiz en su libro Otro territorio en lo referente a la denominada, por él, modernidad-mundo; momento en el que se evidencian profundas transformaciones sociales producto del desarrollo de redes informáticas y comunicacionales que han ocasionado una evidente reconfiguración del espacio. Mutación que necesariamente hace que la aparente estaticidad de conceptos como Estado-Nación, identidad y cultura popular sea revisada y repensada por todos. Para enriquecer la reflexión acude a otros autores como néstor garcía canclini, Jesús martín-BarBero y paul virilio.

  1. Il mondo dentro il mondo

    CERN Document Server

    Barrow, John D

    1991-01-01

    Davvero esistono “lì fuori” leggi di natura, che stanno in attesa di essere scoperte, indipendenti dal nostro modo di pensare, o esse rappresentano soltanto la descrizione più conveniente di ciò che abbiamo visto? Come è nata l’idea stessa di “leggi di natura”? Queste costituiscono la realtà profonda o sono soltanto pezzi di un regolamento che ci siamo dati per organizzare meglio la nostra conoscenza del mondo? o semplici paletti che piantiamo e ci lasciamo alle spalle come segnali via via che procediamo nella giungla dell’esperienza? È possibile che non esistano affatto leggi di natura? Forse esse, e anche l’universo che da esse sembra regolato, sono del tutto creazioni della nostra mente: un’illusione che scompare appena cessiamo di pensarvi. Ma allora, che cosa accadrebbe, se non ci fossero osservatori dell’universo?». Interrogativi di questo genere, che incontriamo sulla soglia del Mondo dentro il mondo, sarebbero suonati eccentrici fino a qualche anno fa. Oggi, al contrario, circ...

  2. Reflexiones sobre territorio e identidad de género en Bolivia.

    Directory of Open Access Journals (Sweden)

    Ana Rosa López

    2013-09-01

    Full Text Available El presente trabajo analiza la relación entre identidad cultural femenina y el territorio en Bolivia. Se reflexiona sobre la Reforma Agraria, la Ley de Participación Popular y el nuevo Estado Plurinacional.

  3. Desarrollo, complejidad y turismo sostenible. El uso del territorio frente a los retos del siglo XXI

    Directory of Open Access Journals (Sweden)

    Wanderléia Elizabeth Brinckmann

    2010-01-01

    Full Text Available El siglo XXI trae consigo grandes retos desafiando a los investigadores de diferentes áreas del conocimiento a estudiar la complejidad del territorio. Entender pues, el movimiento de re-organización y re-funcionalización del territorio a partir de algunos ejes vertebradores como sean el desarrollo y el turismo sostenible, es el reto que proponemos en esta reflexión.

  4. Territorio, innovación y desarrollo rural. El caso del territorio brasileño del Vale dos Vinhedos

    Directory of Open Access Journals (Sweden)

    Jeziorny, Daniel L.

    2016-09-01

    Full Text Available This paper is focused on innovation processes in rural areas. Its author pose that although these processes are encouraged of technical and technological advances, they are also oriented by the logic of capital accumulation. That is why the innovation processes has a political dimension. In base of this thesis, the author analyzes, firstly, the general innovation tendencies taking place in the Brazilian wine sector, and in particular the innovation experiences in the rural area called “Vale dos Vinhedos”, placed in the region of Rio Grande do Sul. Also, he analyzes the governance system in this territory, paying attention to the organization of social and economic players, and their relations with the public institutions at the local level. Finally, the author analyzes how the financial capital decides to change its strategy and to remove from Vale dos Vinhedos to other rural areas (for example, Campanha Gaucha when economic players find difficulties to increase the capital accumulation process.Este artículo trata el tema de la apropiación territorial de los espacios rurales en el marco de procesos de innovación. Su autor plantea la tesis de que los procesos innovadores están configurados por el avance técnico y tecnológico, pero siguen la lógica de acumulación del capital, teniendo por tanto una dimensión económico-política. Sobre la base de este argumento analiza, en primer lugar, las dinámicas de innovación que han tenido lugar en el sector vitivinícola brasileño, centrando el análisis en el territorio denominado “Vale dos Vinhedos”, situado en el Estado de Rio Grande do Sul. Asimismo, analiza los sistemas de gobernanza surgidos en torno a esos procesos innovadores y el modo como se gestionan las interacciones entre los diversos actores sociales, económicos e institucionales presentes en ese territorio. Finalmente, analiza cómo los capitales instalados en el “Vale dos Vinhedos”, al encontrar dificultades para

  5. La geografía del paisaje y el territorio cultural de Los Millares

    Directory of Open Access Journals (Sweden)

    Gusi i Jener, Francesc

    1991-12-01

    Full Text Available Not available.

    La falta de estudios relacionados con una arqueogeografía del territorio cultural del grupo social de Los Millares no permite valorar debidamente las interrelaciones estrechas existentes entre una estructura socio-económica y el medio geográfico en donde se desarrolla. Aún a pesar de los escasos datos paleoambientales que se poseen de los distintos asentamientos pertenecientes a la Cultura de Los Millares, los autores piensan que existió una mayor pluviosidad, así como también una más amplia cobertura forestal en todo el territorio de la Andalucía oriental y Murcia, y por tanto una climatología y paisaje geográfico distintos al actual. Por otro lado, la historia de la investigación en la Geografía, se polarizó desde sus orígenes en torno a quienes deseaban que esta disciplina se conectase estrechamente con la antropología y la historia, y de aquellos otros autores que creían que su estudio debía incidir en aspectos puramente fisiográficos, independientemente de la acción humana en el medio natural. También se subraya la falta de una mayor cooperación entre arqueólogos y geógrafos a la hora de enfocar conjuntamente problemas de investigación en áreas territoriales ocupadas durante los períodos culturales desarrollados a lo largo del Holoceno. Por otra parte, la aparición de la Arqueología Espacial como corriente de investigación ligada a la geografía del territorio y las distintas posiciones ideológicas y metodológicas de la arqueología prehistórica, muchas veces muy semejantes a las suscitadas entre los geógrafos, permiten paralelizar muchos aspectos de ambas disciplinas, ligadas estrechamente a las ciencias de la Tierra y el Hombre. [fr] L'absence d'études en relation a une archéogeographie du territoire culturel du groupe social de Los Millares, ne permet pas évaluer comme il faut les interrelations tres proches existentes entre une structure socio-économique et le milieu g

  6. Il Paesaggio della città della ricostruzione

    Directory of Open Access Journals (Sweden)

    Nicola Giuliano Leone

    2013-01-01

    Full Text Available Il terremoto del Belice e la ricostruzione che ne seguì negli anni a venire segnano il momento di definitiva cancellazione dei paesaggi agrari e, in qualche misura, della stessa civiltà contadina. L’evento cade in un momento di grandi incertezze, nel quale si stavano già misurando le riflessioni sullo sviluppo del territorio, tra le quali ricordiamo quelle di Dolci e Doglio, in un periodo in cui si affacciava una nuova cultura prevalentemente urbana. Dal dibattito emergeranno inizialmente ipotesi molto differenti tra loro, e saranno i sindaci dei vari comuni a farsi carico di una prima aggregazione delle forze per la soluzione dei principali problemi dell’emergenza. Emerge la voglia di confrontarsi con i modelli della cultura europea e le due culture sembrano incontrarsi nella formazione di desideri e soluzioni. Un primo atteggiamento non vede più la campagna e tende a cancellarla attraverso ipotesi di forme dichiaratamente urbane. Un secondo atteggiamento, associabile al primo propone modelli sperimentati in altri paesi. L’evento calamitoso accelerò l’evoluzione di questa parte  del territorio verso mutazioni non tutte volute o necessarie.

  7. Afrochilenos en Arica: Identidad, organización y territorio

    Directory of Open Access Journals (Sweden)

    María Paz Espinosa Peña

    2015-06-01

    Full Text Available Hace catorce años la población afrodescendiente de Arica sale a la luz pública, después de permanecer durante generaciones en un ámbito privado, empañado por un pasado de esclavitud y negación. El siguiente artículo busca dar cuenta de la recuperación y reconstrucción de una identidad, además de la reivindicación y reinvención de una cultura material e inmaterial. Así como de las formas de expresión que han logrado cohesionar a la población afrodescendiente de la zona, dándose a conocer ante la sociedad ariqueña y conformando un movimiento etnopolítico que lucha por ser contabilizado y reconocido como grupo diferenciado frente al Estado chileno. Este proceso organizacional, desde sus inicios se desplegó principalmente en la ciudad de Arica. Sin embargo, con el transcurso del tiempo y las constantes reconfiguraciones al interior del movimiento, también se ha organizado desde una perspectiva rural. Por lo tanto, a partir de distintas territorialidades se manifiestan y reactualizan los discursos, validándose la lucha por ser reconocidos por el Estado chileno. En cuanto a la información recopilada para este artículo, proviene de entrevistas en profundidad realizadas a personas afrodescendientes, que habitan Arica y el valle de Azapa. Lo que ha sido complementado con bibliografía relacionada con temáticas como identidad, etnicidad y territorio.

  8. El territorio de las nuevas economías metropolitanas

    Directory of Open Access Journals (Sweden)

    Ricardo Méndez

    2007-12-01

    Full Text Available Las transformaciones económicas recientes ocurridas en las regiones metropolitanas suponen importantes cambios en las pautas de localizado n de las empresas, el dinamismo y la organización espacial de las diferentes actividades, empleos y funciones, con evidentes efectos sobre la forma urbana. Un diagnóstico sobre la nueva geografía económica de las ciudades mundiales y sus regiones metropolitanas es un factor clave para orientar las nuevas políticas de promoción económica y planeamiento urbanístico. El artículo propone una revisión crítica de diferentes conceptos y teorías sobre la actual relación entre economías y territorios metropolitanos, analiza las tendencias recientes en la organización espacial de las actividades y destaca la importancia de las respuestas locales en la construcción de ciudades competitivas e innovadorasThe recent economic changes in metropolitan regions have given rise to significant shifis in the locational strategies of firms, the spatial organisation of different activities, functions and jobs, with direct consequences for urban form. A diagnosis of the new economic geography of world cities and metropolitan regions is a key factor in shaping new economic promotion policies and urban planning. This paper offers a critical review of diverse concepts and theories relating to the recent territorial evolution of metropolitan economies, it analyses the recent trends in spatial organisation of activities, and it emphasises the strategic value of local responses in the construction of competitive and innovative cities

  9. Mapping of critical loads of acidity for the Italian terrestrial ecosystems; Mappa dei carichi critici di acidita' totale riferita al territorio italiano

    Energy Technology Data Exchange (ETDEWEB)

    Bonanni, P.; Brini, S.; Delmonaco, G.; Liburdi, C.; Trocciola, A.; Vetrella, G. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1999-07-01

    In this report the mapping of critical loads of acidity for the Italian terrestrial ecosystems is presented. The level 0 method (Stockholm Environment Institute) has been used to determine sensitivity to acid deposition; this semi-quantitative method has been modified to address some Italian characteristics. The sensitivity of the Italian soils to acidification is not particularly elevated: there are really only few small areas with poor tolerance to acid depositions in the north-east Italy, Alpine and Prealpine region. [Italian] Nel presente relazione vengono riportati i risultati della mappatura riferita ad ecosistemi terrestri del territorio italiano, dei carichi critici per l'acidita' totale. Il calcolo dei carichi e' stato eseguito sulla base della metodologia messa a punto dallo Stockholm Environment Institute con alcune modifiche per adattarlo meglio alle caratteristiche del territorio italiano. Si dimostra che la sensibilita' dei suoli italiani all'acidificazione non sia particolarmente elevata: sono state riscontrate infatti solo alcune aree, peraltro con superficie limitata, con una scarsa tolleranza alle deposizioni acide nelle zone del Nord Est, in zona alpina e prealpina.

  10. Critical load of acid precipitations. Mapping of Italian regions; Mappa dei carichi critici di acidita' totale riferita al territorio italiano

    Energy Technology Data Exchange (ETDEWEB)

    Bonanni, P.; Brini, S.; Delmonaco, G.; Liburdi, R.; Trocciola, A.; Vetrella, G. [ENEA Centro Ricerche Casaccia, S. Maria di Galeria, RM (Italy). Dipt. Ambiente

    1999-07-01

    In this report the mapping of critical loads of acidity for the Italian terrestrial ecosystems is presented. The level O method (Stockholm Environment Institute) has been used to determine sensitivity to acid deposition; this semi-quantitative method has been modified to address some Italian characteristics. The results show that the sensitivity of the Italian soils to acidification is not particularly elevated: there are really only few small areas with poor tolerance to acid depositions. These areas are in the north-east of Italy, in Alpine and Prealpine region. [Italian] Nel rapporto vengono riportati i risultati della mappatura, riferita agli ecosistemi terrestri del territorio italiano, dei carichi critici per l'acidita' totale. Il calcolo dei carichi critici e' stato eseguito sulla base della metodologia messa a punto dallo Stokholm Environment Institute; a questo metodo semi-quantitativo sono state apportate alcune modifiche per meglio adattarlo alle caratteristiche del territorio italiano. Dall'analisi dei risultati ottenuti, si evince come la sensibilita' dei suoli italiani all'acidificazione non sia particolarmente elevata: sono state riscontrate infatti solo alcune aree, peraltro con superficie limitata, con una scarsa tolleranza alle deposizioni acide. Tali aree sono localizzate nell'Italia nord-orientale, in zona alpina e prealpina.

  11. El Estado sin territorio: La desaparición del territorio debido al cambio climático

    Directory of Open Access Journals (Sweden)

    Mariano J. Aznar Gómez

    2013-12-01

    Full Text Available Diversos y fundados análisis científicos demuestran que una de las derivadas del denominado “cambio climático” es el calentamiento global del planeta y, con él, la posible elevación significativa de los niveles de mares y océanos en el planeta. Ello podría suponer, en determinados casos, la desaparición bajo las aguas de amplias porciones del territorio de diversos Estados, muy particularmente de ciertos Estados archipelágicos del Pacífico que podrían ver, incluso, la total desaparición de sus espacios terrestres. Con ello desaparecería uno de los elementos constitutivos del Estado, cuestionándose entonces sus efectos en la soberanía e, incluso, en la propia existencia de dicho Estado. Quedaría igualmente afectado otro elemento de la estatalidad: la población, que podría verse desplazada conformando una nueva tipología de “desplazados climáticos”. El Derecho internacional actual ofrece diversas soluciones a dichos problemas, si bien parte de la adopción de esas soluciones implicarían la asunción de opciones políticas de cierta envergadura con efectos jurídicos reseñables. Este trabajo analiza parte de estas cuestiones, proponiendo algunas de las mismas como posibles soluciones a la posible alteración territorial o la desaparición de ciertos Estados debida al cambio climático.

  12. Nuovi territori di 'ndrangheta. Il caso di Reggio Emi

    Directory of Open Access Journals (Sweden)

    Federica Cabras

    2018-03-01

    Full Text Available La ‘ndrangheta a Reggio Emilia rappresenta un fenomeno trentennale. Il presente articolo si propone di analizzare le tappe fondamentali della sua storia nella provincia emiliana, le sue caratteristiche strutturali e il graduale processo di integrazione socio-economica del clan sul territorio. Chiama in causa anche il sistema cooperativo emiliano, il quale – seppur mai coinvolto nelle inchieste della magistratura -  costituisce tradizionalmente il principale operatore economico in quei settori chiave dell’imprenditoria mafiosa.  Parole chiave: mafia, ‘ndrangheta, economia, Reggio Emilia, imprese cooperative   ‘Ndrangheta is a 30-year phenomenon in Reggio Emilia. This article aims to inquire   the fundamental steps of its development, identifying the structural features of the organization and analysing its spread within the socio-economic context. Moreover, this essay focuses on the role of cooperative ventures in the key sectors of mafia’s investments. The main findings put into light many links between mafia enterprises and Emilian cooperative system. Keywords: mafia, ‘ndrangheta, economy, Reggio Emilia, cooperative venture

  13. Territorio flexible en la semiperiferia: La frontera norte mexicana

    Directory of Open Access Journals (Sweden)

    Ovidio González Gómez

    1999-05-01

    Full Text Available En este trabajo se realiza una discusión sobre la aplicabilidad de la propuesta de la denominada corriente regulacionista en torno a la espacialidad de los procesos recientes de industrialización, para un caso dentro de los países no centrales, en particular sobre el proceso de industrialización ocurrido en la Frontera Norte mexicana, desde mediados de la década pasada. Lo que se cuestiona, primeramente, a nivel teórico, es la utilidad de esta propuesta para parte de los estados no-centrales del Sistema Mundial. También se desarrollan, en el mismo plano, las objeciones principales en relación a sus supuestos generales al aplicarse esta teoría tanto al centro del Sistema Mundial como también al resto de ésta. Las características principales de este reciente proceso de industrialización en el territorio del norte mexicano son esbozadas para luego ser confrontadas a los supuestos subyacentes a la teoría regulacionista. Desde la crítica formulada a esta escuela de pensamiento, se genera una propuesta interpretativa, basada primeramente sobre el concepto de espacio de flujos, y después sobre la flexibilidad en el uso de la región fronteriza del norte mexicanoA debate is proposed in this paper on the suitability of the regulationist proposal to explain the spatial implications of recent industrial processes. This suitability is questioned for a particular territory in a non-central Nation-State, the Mexican Northern Border, from the mid-dle 1980´s. At a theoretical level, the usefulness of this for parts of the non-central nations of the World-System. On the same level the main objections on its general assumptions when this theory is applied to the center of the World-System as well as to the rest of it. Are also developed he main characteristics of the new industrialization process in the northern Mexican territory are depicted. These features are then confronted to the underlying assumptions of the regulationist theory. And, from

  14. Il secondo principio

    CERN Document Server

    Atkins, Peter W

    1988-01-01

    L'asimmetria della Natura ; l'indicatore di una trasformazione ; scivolando verso il caos ; la quantificazione del caos ; la potenzialità del caos ; le trasformazioni del caos ; il dominio della temperatura ; caos costtrutivo ; le strutture del caos.

  15. CONFIGURACIONES DE IDENTIDAD EN TERRITORIOS DEL TURISMO. CONDICIONES GENERALES EN GALICIA

    Directory of Open Access Journals (Sweden)

    Elena de Uña Álvarez

    2011-01-01

    Full Text Available El fenómeno de la puesta en valor del territorio para el turismo refleja categorías de referentes en la definición de una identidad cultural. El análisis geográfico parte de la interacción dinámica entre territorio, identidad e imagen. La definición, la representación y la difusión de una propuesta de identidad configuran en la actualidad un conjunto de procesos relevantes en el territorio tanto para identificar y afianzar su carácter turístico como para generar diversas potencialidades de uso en el escenario global del turismo. Se presentan una serie de consideraciones ilustradas en Galicia.

  16. La secesión de territorios no coloniales y el soberanismo catalán

    Directory of Open Access Journals (Sweden)

    Carmen López-Jurado Romero de la Cruz

    2013-12-01

    Full Text Available En este trabajo se analizará la problemática de la secesión de territorios no coloniales a la luz de los principios estructurales del Derecho internacional y sobre la base de un análisis de la práctica de los Estados. En lo que se refiere al Derecho de la UE, se analizará en qué condiciones un territorio que se segrega de un Estado miembro, como podría ser eventualmente el de Cataluña, puede pertenecer a esta organización internacional, y si existen precedentes en la materia.

  17. Música y fiesta en la construcción del territorio nasa (Colombia

    Directory of Open Access Journals (Sweden)

    Carlos Miñana Blasco

    2008-01-01

    Full Text Available El pueblo nasa , en el sur occ idente andino de Colombia, reafirma y construye a diario sus territorios no sólo por medios legales, trabajando o luchando por la tierra, sino también con ritos, fiestas, música y bailes. Este artículo, basado en un trabajo de campo de varios años, señala vínculos significativos y continuidades entre los territorios de los cacicazgos precolombinos y las fronteras delimitadas y celebradas por las actuales prácticas rituales y musicales.

  18. Estrategias de integración del patrimonio cultural en el ordenamiento del territorio

    OpenAIRE

    Gallego Muñoz, Paula Andrea

    2014-01-01

    Resumen: Estudio de caso desarrollado en el municipio de Concepción Antioquia, que partiendo de la existencia de una declaratoria nacional para la protección del centro histórico, explora desde los actores del territorio, las percepciones e importancia del patrimonio tangible e intangible y las estrategias para gestionarlo y articularlo a los instrumentos de planificación del territorio, visto éste más allá de los límites y elementos físico-bióticos, incluye dimensiones socio-culturales, polí...

  19. Pensar e intervenir el territorio a traves de la Teoria del Actor-Red

    Directory of Open Access Journals (Sweden)

    Juan E. Cabrera

    2011-03-01

    Full Text Available El propósito de este artículo es reflexionar sobre las coincidencias entre la forma de ver el territorio como red, algunas posturas teóricas sobre su concepto y la teoría del actor-red. Sobre lo anterior se centra en proponer una forma de entender las relaciones entre actores cuando se va a intervenir el territorio a través de políticas públicas como la planificación utilizando un modelo de gestión territorial a través de las orientaciones de la TAR.   

  20. Settlement, territory and notarial formulas: a verification (Verona, IX-XII century Insediamento, territorio e formule notarili: una verifica (Verona, IX-XII secolo

    Directory of Open Access Journals (Sweden)

    Andrea Brugnoli

    2011-10-01

    well as synchronous – allows instead to highlight their links with the different practices in the territory: not only through the presence of landlordship, but also the structure of habitat, the forms of solidarity and the access to common resources.

     

    L’organizzazione del territorio rurale nel medioevo e la sua conoscibilità attraverso le tecniche ubicatorie utilizzate dai notai costitiscono un tema classico nella storiografia italiana della seconda metà del Novecento. La documentazione prodotta nel territorio veronese ben si presta per una verifica delle ipotesi e la formulazione di alcune linee guida per l’interpretazione delle formule notarili per quanto attiene all’insediamento e alla territorialità di villaggio. Il numero di documenti prodotti e conservati nel Veronese per i secoli IX-XII, e la loro omogeneità quanto a istituzioni che ce li hanno conservati e tramandati, permette di affrontare una complessa analisi che deve considerare diverse variabili. Sul piano documentario si tratta di possibili varietà, al limite dell’individualità, di formulari e di usi notarili; a queste si uniscono differenze geografiche, di assetti proprietari, dello sviluppo di presenze signorili e di pratiche agrarie, oltre che di popolamento che caratterizzano questo territorio. In particolare la varietà del quadro geografico, equamente suddiviso tra una fascia collinare di non disprezzabile estensione, una fascia di pianura asciutta e irrigua e una di bassa pianura soggetta a esondazioni si prospettava come un elemento positivo per identificare i diversi fattori attivi nella costruzione dell’insediamento rurale, la sua organizzazione e rappresentazione. Il presupposto di partenza è che le formule ubicatorie siano articolate in schemi frutto di una dialettica tra cultura notarile da un lato e percezione dell’organizzazione dello spazio dall’altro; quest’ultima a sua volta risultato del rapporto che si instaura tra le comunità umane e il

  1. El territorio nacional de Misiones a través de su población: aproximaciones a partir del censo de territorios nacionales de 1920

    Directory of Open Access Journals (Sweden)

    Luz Irene Pyke

    2016-10-01

    Full Text Available El presente artículo propone el análisis de la composición socio-demográfica del territorio de Misiones a partir de los resultados del censo específico de territorios nacionales de 1920. Este análisis abordará tanto los resultados de este censo, como sus condiciones de producción y los objetivos políticos que inspiraron su realización. A través de este análisis se buscará, en primer lugar, abordar la realización de este censo como parte de la agenda de ampliación de derechos políticos del gobierno radical de la Argentina. En segundo lugar, conocer las características generales de la población de Misiones, en cuanto a su composición según sexo, edades y origen. En tercer lugar, observar las características poblacionales en las zonas fronterizas del territorio. El objetivo será aportar al conocimiento socio-demográfico de Misiones, en tanto permite observar las particularidades en la composición poblacional de las zonas fronterizas que constituyeron los escenarios de un conjunto de movimientos políticos de carácter transfronterizo entre las décadas de 1920 y 1930.

  2. La incorporación de los territorios nacionales en el proceso de consolidación del estado argentino. El caso del territorio de la Pampa Central

    Directory of Open Access Journals (Sweden)

    Marisa Moroni

    2005-01-01

    Full Text Available En la mayoría de los escritos de la élite letrada argentina del XIX, se identificó a la civilización como una manifestación de la identidad nacional, supuesto que las llevó a legitimar su función civilizadora y a impulsar el proceso de consolidación del Estado que requería la ocupación total del territorio, aún en manos de los indígenas a los que se responsabilizaba, junto con los caudillos, del fracaso de la unificación nacional. Desde las estructuras del poder estatal, se definió a los nuevos territorios como espacios vírgenes con infinitas posibilidades y ventajas económicas para explotar. Este argumento político atrajo pobladores -nacionales y extranjeros- que ocuparon y encaminaron la organización productiva de las futuras provincias. En este trabajo se realiza una aproximación al proceso de incorporación y posterior organización institucional de las tierras fronterizas incorporadas con la "Conquista al Desierto". En particular, se analiza la estructura político-administrativa del Territorio Nacional de la Pampa Central, constituido como tal en 1884, con el establecimiento de las primeras autoridades militares destinadas a fundar poblaciones y administrarlas políticamente.

  3. Evaluation of IL-2, IL-6, IL-8 and IL-10 in Malignant Melanoma Diagnostics.

    Science.gov (United States)

    Kucera, Radek; Topolcan, Ondrej; Treskova, Inka; Kinkorova, Judita; Windrichova, Jindra; Fuchsova, Radka; Svobodova, Sarka; Treska, Vladislav; Babuska, Vaclav; Novak, Jaroslav; Smejkal, Jiri

    2015-06-01

    The aim of the present study was to evaluate the usefulness of four interleukins (IL-2, IL-6, IL-8 and IL-10) for melanoma detection and correlate these interleukins with sentinel node metastasis positivity. A group of 236 persons was assessed: 175 patients with melanomas and 61 healthy persons. Melanoma patients were divided to four groups according to Breslow score. We determined IL-2, IL-6, IL-8 and IL-10 in each plasma sample. Interleukin plasma levels were assayed using a Human Cytokine Milliplex Map kit. Measurements were performed using the Bio-Plex MAGPIX Multiplex Reader. Plasma samples were collected prior to surgery or any other form of treatment. All melanoma diagnoses were histologically verified. We compared interleukin plasma levels in the healthy group and plasma levels in each Breslow score stage. In the first Breslow score stage, IL-2 (pmelanoma. IL-2 and IL-6 appear to be prognostic biomarkers. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  4. I sistemi informativi geografici nella gestione del territorio aperto: il censimento delle strade vicinali nel Comune di Pontassieve (FI

    Directory of Open Access Journals (Sweden)

    Ilaria Scatarzi

    2015-10-01

    Full Text Available The research started from a need of the local authority to provide an updated data bank to create a dynamic mangement system for open terrority through the construction of a geographic relational database with web interface for various users.

  5. Le biomasse come opportunità per il territorio: analisi tecnico-economica per la Regione Basilicata

    Directory of Open Access Journals (Sweden)

    Severino Romano

    2016-01-01

    Full Text Available In Basilicata region there is a considerable amount of unused wood as well as the capacity to use it as feedstock for the production of bioenergy. Thus, the supply of renewable energy could be increased through greater utilization of forest biomass. However, for a better planning of the production and processing chain, the energy and forestry sectors require better estimates of the availability of unused roundwood and residues. The aim of the research was the development of a model for the spatial evaluation of biomass quantities obtainable from forestland. The results obtained point out a significant amounts of biomass distributed on most of the territory; b good opportunities related to white certificate trading and c potential of business creation, entrepreneurship and local employment.

  6. Il ruolo dei GIS nello studio e conoscenza del Territorio nell’ambito della comunicazione tra pubblica amministrazione e cittadini

    Directory of Open Access Journals (Sweden)

    Vincenzo Consortii

    2015-10-01

    Full Text Available The definition of a participatory governance plan of the area, causes the involvement of many actors in the decision-making process, and a significant change in the relationship between state institutions, local authorities and citizens. In this context, extremely dynamic, that requires simple and effective interactions the use of GIS allows a complete representation of the area with a natural integration if communication and presentation of information. The use of ICT technologies, and GIS, to be operationally e ective and with significant results, however, requires a modeling and application architecture that from the spatial data, will be able to combine functional flexibility and completeness of information, and fort this reason, to achieve the objectives requires a constant and continuous collaboration between the di erent actors.

  7. Colombia: territorios en disputa, luchas por el sentido y nueva hegemonía

    Directory of Open Access Journals (Sweden)

    Felipe Pineda Ruiz

    2016-01-01

    Full Text Available En suma, el derecho a la ciudad y al territorio, marcan una verdadera contradicción de fondo entre la clase política y el país político enfrentado a los anhelos de la sociedad civil, en Colombia.

  8. CONFIGURACIÓN REGIONAL DEL TERRITORIO RELIGIOSO EN MÉXICO, 1950-2000

    Directory of Open Access Journals (Sweden)

    José Luis Molina Hernández

    2003-01-01

    Full Text Available En este ensayo analizamos la relación entre territorio y religión desde tres perspectivas distintas: en los aspectos teórico y metodológico revisamos diferentes enfoques para el análisis de las regiones en general y para la construcción de los conceptos de territorio religioso y regiones religiosas en particular; desde un punto de vista histórico describimos algunas de las formas en que la religión resignifica al territorio a partir de su propia dinámica; y en el terreno empírico, con base en los datos de los censos nacionales de México de 1950 a 2000, reconstruimos la configuración regional del territorio religioso mexicano para cada variable religiosa en cada década. De esta forma se ilustra la distribución regional de las corrientes religiosas en México y la evolución histórica de esta distribución en la segunda mitad del siglo pasado, y con ello se sientan las bases para futuros análisis que incorporen elementos de orden más cualitativo

  9. Sviluppo di un sistema gis e webgis a supporto delle attività di bonifica del sito d'interesse nazionale di Biancavilla

    OpenAIRE

    Famoso, Daniele Antonino

    2015-01-01

    In seguito al rilevamento di un cluster di casi di mesotelioma nella città siciliana di Biancavilla, che si trova alle pendici del vulcano Etna, sono stati effettuati studi epidemiologici ad hoc e monitoraggi ambientali per evidenziare il ruolo e l eziologia di una fibra asbestiforme presente in una cava di pietra. Una dettagliata analisi chimica di anfiboli contenuti in questo materiale ha permesso la scoperta e l'individuazione di una nuova fibra: la fluoroedenite (NaCa2Mg5 (Si7Al) O22F2...

  10. La raccolta storico-topografica della città e del territorio di Perugia di Achille Bertini Calosso fra estetica idealistica e tardo positivismo storico / The historical-topographic collection of Perugia by Achille Bertini Calosso between idealistic aesthetics and late historic positivism

    OpenAIRE

    Patrizia Dragoni

    2011-01-01

    La “Raccolta Storico-Topografica della Città e del Territorio di Perugia”, che Achille Bertini Calosso, Soprintendente ai Monumenti e alle Gallerie dell’Umbria, allestisce nel 1946, con il progetto di farne il “Museo di Perugia”, rispecchia fedelmente la cultura museale maturata nella prima metà del Novecento in Italia e, per molti aspetti, in altri paesi europei. Da un lato, infatti, sia per la sua origine, che può farsi risalire all’“Esposizione Generale Umbra” del 1899 e al conseguente pro...

  11. La formación del territorio del noroeste del río Ohio en Estados Unidos (1787 y la formación de los territorios nacionales en Argentina (1884. Influencias, semejanzas y diferencias

    Directory of Open Access Journals (Sweden)

    Perla Zusman

    2010-12-01

    Full Text Available A partir de comprender la influencia del modelo territorial norteamericano en la constitución del territorio de la Argentina, el artículo analiza la formación del Territorio del Noroeste de Río Ohio de los Estados Unidos (1787 y la constitución de los Territorios Nacionales en Argentina (1884. A través del estudio de las normas que organizan dichos territorios se identifican las semejanzas y diferencias en su proceso de configuración. Finalmente se plantean algunas hipótesis que podrían contribuir a explicar el corto mantenimiento de los Territorios en Estados Unidos y la larga perduración de los Territorios Nacionales en Argentina. Se considera que la segunda expansión colonial y la vigencia de formas de organización territorial asociadas al poder tutelar podrían explicar el interés por mantener los Territorios Nacionales en el contexto argentino.

  12. Il muro come galleria

    Directory of Open Access Journals (Sweden)

    Duccio Dogheria

    2008-06-01

    Full Text Available Il muro, nel suo grigio rigore formale, nella sua fredda geometria, nel suo intento divisorio, nasconde spesso il cielo. Sovente il linguaggio dell’arte, ma non di meno quello della comunicazione, hanno interferito con le sue algide barriere. In molti casi, beninteso, non è che il potere in altre forme, che interferisce con se stesso: pensiamo ai bandi affissi agli angoli delle città, o le lettere d’indulgenza papali -spesso impreziosite da miniature al punto da poterle considerare antenate dal manifesto- che nel corso del medioevo venivano affisse sulle porte delle chiese.

  13. Il governo del territorio e del paesaggio rurale nello spazio “terzo” periurbano. Il parco agricolo come strumento di politiche e di progetto

    Directory of Open Access Journals (Sweden)

    David Fanfani

    2015-11-01

    Full Text Available The recent transformations and evolution of the urban and metropolitan systems in Europe, as well as in Italy, have often produced settlements forms where the edge between urban ad rural spaces goes to fade and where the legacy of the rural society and of the agricultural landscape is often eroded under the urban equipments and housing development pressure. Nevertheless in such as settlements the role of the open spaces remains still pivotal. Infact they can provide very helpful “public goods” - as such as urban ecosystem and urban-rural landscapequality-and -atthesametime-goods,facilitiesandamenitiesfortheurbanpeople–assuchasshort foods supply chain, recreational, tourist, social and cultural services. For planning agenda facing this context of mingled urban-rural patterns and functions means to deal with new planning and governance strategies. Agricultural park device seems to fit with the problems at stake. In many cases in Europe and Italy it permits to pursue the multifunctional and integrated goals for managing the periuban places and to set up the operational framework to develop territory and landscape designs aimed to protect and, sometimes, recreate the identitary, environmental, social and economic values of the open spaces. 

  14. Raised IL-6 Levels

    African Journals Online (AJOL)

    user

    ABSTRACT. Objectives: The objectives of the study were to compare plasma levels of IL-6 in HIV positive and. HIV negative individuals and to correlate them with. CD4 count. Materials and methods: A cross-sectional study was carried out at the University Teaching Hospital in Lusaka, Zambia. IL-6 and CD4 were assessed ...

  15. Il teatro degli spiriti.

    OpenAIRE

    Chiara Pussetti

    2013-01-01

    Questo saggio è dedicato a un culto di possessione, in cui tutte ledonne, investite dagli spiriti degli uomini morti prima dell’iniziazione, compiono un percorso iniziatico parallelo a quello maschile, consentendo a queste anime, potenzialmente pericolose, di completare il cammino che non hanno potuto percorrere da vivi e quindi di raggiungere serenamente il mondo dei morti, come antenati protettori del villaggio

  16. Marketing; Il marketing

    Energy Technology Data Exchange (ETDEWEB)

    Muscigna, M. [ENEA, Centro Ricerche Casaccia, S. Maria di Galeria, RM (Italy). Dipt. Innovazione

    1999-07-01

    The report discusses marketing strategies oriented to the organizations and analyzes its critical factors, which determine the success of the organization activity. [Italian] Il rapporto analizza i caratteri delle strategie del marketing orientato all'impresa. Vengono infine analizzati i fattori critici che determinano il successo o l'insuccesso delle scelte aziendali.

  17. Il Bosone di Higgs

    CERN Multimedia

    Hemmer, Sabine

    2018-01-01

    Poster di ATLAS sul bosone di Higgs indirizzato al pubblico generico, che spiega il meccanismo di Brout-Englert-Higgs e la sua importanza. Spiega anche il ruolo del Bosone di Higgs, come viene cercato, il percorso della sua scoperta e cosa viene dopo la scoperta. Disponibile anche in Francese (http://cds.cern.ch/record/1697501) e Inglese (http://cds.cern.ch/record/1697389). Non esitate a utilizzarlo nelle sedi dei vostri Istituti e negli eventi divulgativi! Il poster è in formato A0. Cliccate sull'immagine per scaricare il .pdf ad alta qualità e stamparlo dove preferite. Per qualisasi domanda o commento potete contattare atlas-outreach-coordination@cern.ch

  18. La frattura dell'estremitá prossimale del femore: valutazioni epidemiologiche basate su cinque anni di ricoveri ospedalieri della popolazione residente nel territorio della ASL di Firenze

    Directory of Open Access Journals (Sweden)

    D. Papini

    2003-05-01

    Full Text Available Obiettivo: l’alta prevalenza negli anziani e l’elevato costo sociale della frattura dell’estremità prossimale del femore (FPF, ha motivato una descrizione epidemiologica del fenomeno nella nostra area. Metodi: per la popolazione dei circa 800.000 residenti nel territorio della ASL di Firenze, basandosi sulle schede di dimissione ospedaliera, è stata studiata la distribuzione dei ricoveri per ASL, per diagnosi, per sesso e per fasce di età. Escludendo i ricoveri ripetuti, è stato stimato il tasso di incidenza. È stata calcolata la degenza media e il tempo di attesa per un eventuale intervento chirurgico. Risultati: il tasso di incidenza stimato sui ricoveri è elevato, sebbene costante negli anni: i valori medi nel periodo sono di 2627,08/100.000 per i soggetti con 85 o più anni d’età e di 1264,25/100.000 nella fascia d’età 80-84 anni. Tale tasso presenta un andamento esponenziale in funzione dell’età a partire da 50 anni e nelle fasce d’età avanzata le femmine mostrano una incidenza circa doppia. Anche la degenza media risulta più elevata nelle fasce di età più anziane. Per i 4 interventi chirurgici più frequenti abbiamo dimostrato che la media della degenza pre-intervento è significativamente maggiore nei deceduti rispetto ai dimessi a domicilio. Conclusioni: il tasso di incidenza di FPF è risultato superiore alla media nazionale sebbene stabile negli anni. La distribuzione dell’incidenza per fasce di età e sesso rispecchia i valori di letteratura. La correlazione tra degenza media pre-intervento e mortalità intaospedaliera è un reperto interessante che richiede ulteriori analisi per una corretta interpretazione.

  19. Cinema e territorio. Processi di valorizzazione e promozione (cineturistica delle destinazioni minori / Cinema and territory. Processes of enhancement and (cinetouristic promotion of minor destinations

    Directory of Open Access Journals (Sweden)

    Angela Cresta

    2016-05-01

    Il contributo, a partire da un’analisi delle più celebri pellicole girate in Irpinia, rilegge dunque il legame tra Cinema e territorio alla luce delle esperienze di progettualità in corso che vedono nel cine-turismo una possibile forme di sviluppo locale da valorizzare. The objective of the paper is to make a reflection on the relationship between cinema, creativity and practical tourism in the processes of development and promotion of cinetourism which affect, in particular, the minor destinations. To this end, the experience of Irpinia is presented, where the authenticity of the places and the aspirations of a few enlightened by love for the “Seventh Art” has, since the early twentieth century, inspired several film projects, mixing suggestions real with virtual effects film, have proposed a transposition of the culture and customs, traditions and ways of life of Irpinia. A combination between the cinema and Irpinia which transforms Avellino, at the time one of the poorest and remotest provincial of Italy, the world capital of cinema neorealist; able to influence actively on backwardness typical of southern reality. The contribution, through an analysis of the most famous films shot in Irpinia, reads the link between cinema and territory based on the experience of existing projects that see in cine-tourism possible forms of local development to be enhanced.

  20. Paisaje e imagen: formas y herencias en la construcción cultural del territorio agrario

    Directory of Open Access Journals (Sweden)

    Prada Llorente, Esther Isabel

    2013-12-01

    Full Text Available The history of rural areas gives rise, as a result of interaction between residents and the environment, to a dense network of permanencies, distributed along a scale ranging from the domestic to the territorial. This amounts to forms unfolding as landscape, both in terms of significant image and living heritage. Three municipalities in the Western Spanish Meseta are analyzed with the help of images, historical records and local enquiries. The cases selected show in different degrees the influence of land consolidation policies. The agrarian system, at the territorial, urban and architectonic scales, is scanned in search of the key elements of landscape character. Different tools are combined: direct questionnaires, archival research and a reflective form-interpretation by means of drawing, as well as advanced land mapping and photographing. The outcomes are a taxonomy of evolutive responses to land use, an array of detected landscape values and the determination of landscape character, leading to innovative proposals for rural land planning policy.La historia del espacio agrario, merced a la interacción entre pobladores y medio, genera una rica red de permanencias, en escalas que van de lo territorial a lo doméstico: un despliegue formal como paisaje, entendido como imagen significativa y patrimonio vivo. A través de la imagen, la documentación antigua y el estudio del territorio se analizan tres términos municipales del Occidente mesetario, Destriana, Escuadro y Brincones. Los casos elegidos muestran de forma diferenciada el influjo de la concentración parcelaria. El sistema agrario, en sus escalas territorial, urbana y arquitectónica, es escudriñado en busca de las claves del carácter paisajístico, mediante la encuesta oral, el registro documental, la interpretación reflexiva a través del dibujo, y las técnicas cartográficas y fotogramétricas avanzadas. La diversidad de respuestas evolutivas ante la gestión del medio, el

  1. Analisi tipologiche e morfologiche a supporto della manutenzione programmata con l’ausilio di rilievi catastali ed analisi Istat in operazioni di esproprio

    Directory of Open Access Journals (Sweden)

    Agata Lo Tauro

    2012-06-01

    Full Text Available A seguito di uno studio iniziato nel 1993 presso la Manchester University, su city centres italiani ed inglesi, è stata avviata una indagine sulle trasformazioni diacroniche e sincroniche delle principali tipologie edilizie utilizzando analisi archivistiche, storiche e strumenti normativi, in primis coniugate con la computer graphics e nella mid-term phase con la geomatica in genere. La fase finale della ricerca ha evidenziato la necessità di implementare strategie di “manutenzione programmata” capaci di “prevenire piuttosto che curare”, utilizzando varie tipologie di Open Data implementando approcci pluridisciplinari. Come case-study è stato scelto il centro storico di Acireale. Typological and morphological analysis to support the mainte-nance program with the help of cadastral surveys Following a study that began in 1993 at Manchester Univer-sity, city centers in Italy and UK started an investigation on the diachronic transformations and synchronic analysis of the main building using archival, historical and regulatory instruments, primarily conjugated with computer graphics and in the mid-term phase with the geomatics in general. The final phase of the  research  highlighted  the  need  to  implement  strategies for "scheduled maintenance" capable of  "prevention rather than cure", using various types of Open Date implementing multidisciplinary approaches. As a case study was chosen the historical center of Acireale.

  2. Il colore delle cose

    Directory of Open Access Journals (Sweden)

    Vincenzo Vitiello

    2017-09-01

    Full Text Available Tema di questo saggio è l’operare della riflessione. Vitiello, dopo essersi soffermato sulla «frattura» tra la riflessione (il «vedersi» e il suo operare in Valéry, si concentra sul processo, descritto da Hegel nella Fenomenologia dello spirito, dell’esperienza della coscienza che s’eleva a coscienza dell’esperienza. La conclusione è fortemente critica: Hegel fallisce la mèta nel punto stesso in cui la raggiunge. Infatti nel sapere assoluto, nella visione compiuta, perfetta di sé, della luce che vede luce, viene meno proprio l’esperienza della coscienza, il suo divenire, la sua «imperfezione». La critica a Hegel, passando attraverso Nietzsche, si amplia a critica del linguaggio, in particolare del linguaggio dell’«essere» e  dell’«è», e delle tautologie heideggeriane quali «das Ereignis ereignet», «das Ding dingt», «die Welt weltet». Un importante passaggio del testo è quello sul linguaggio teatrale in cui la parola sembra riacquistare il legame originale tra la voce e il gesto, che tuttavia restano divisi, perché proprio il medio che li lega, il «colore» della parola, è «fuori» della parola e del gesto. Resta la parola dell’agire, dei pragmata, in cui il fare si espone nella sua modalità più propria: nell’immediatezza del patire: il grido di dolore; o nella mediatezza riflessiva dell’imperativo morale: Handle! I due opposti «colori» delle cose.

  3. Mirando a la Pachamama: globalización y territorio en el Tarapacá andino

    Directory of Open Access Journals (Sweden)

    Sergio Gonzu00E1lez Miranda

    2004-01-01

    Full Text Available Este artículo aborda la distancia cultural entre las poblaciones indígenas y la sociedad occidental desde la Colonia hasta nuestros días a través del concepto tiempo y espacio (devenir y territorio, empleando el concepto agua como un elemento vital y ritual. Se analizan las oportunidades y los riesgos que les plantea la globalización a las comunidades andinas, ofreciendo una propuesta, basada en la teoría de Sergio Boisier, que podría resolver el dilema entre globalización y desarrollo endógeno en la sociedad indígena. Se señala la importancia de la nueva geografía cultural, como disciplina, para entender la importancia del territorio en sociedades y culturas no occidentales como la andina.

  4. La ocupación mercantil de territorios ajenos: El turismo como forma oculta de imperialismo

    Directory of Open Access Journals (Sweden)

    Francisco Muñoz de Escalona

    2013-04-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 La doctrina convencional llama turismo a los viajes vacacionales junto con los servicios de transporte, accesibilidad y hospitalidad, unos servicios que deben su existencia a las necesidades logísticas de las operaciones bélicas, mediante las cuales se ocupan territorios ajenos. La industria del turismo, que necesitas esos mismos servicios pone a disposición de los turistas la posibilidad de ocupar transitoria, pacífica y mercantilizada territorios ajenos. La similitud se completa en la medida en la que los desplazamiento bélicos y los vacacionales son circulares (de ida y vuelta y se apoyan en una programación de los mismos.

  5. "El territorio también se mueve" : relaciones sociales, historias y memorias en Pulmarí (1880-2006)

    OpenAIRE

    Papazian, Alexis

    2015-01-01

    Esta tesis analiza, a partir de un abordaje interdisciplinario, el devenir del territorio, nombrado desde distintas agencias, como Pulmarí. Se propone analizar el pasado-presente-futuro en esta región a partir de conflictos territoriales actuales que involucran a diferentes actores sociales y hacen de Pulmarí un territorio particular a la vez que comparable. Fil. Papazian, Alexis. Universidad de Buenos Aires. Facultad de Filosofía y Letras.

  6. Geografía y migración: movimientos; territorios y territorialidades

    Directory of Open Access Journals (Sweden)

    Eduardo Ramón San Marful Orbis

    2014-06-01

    Full Text Available En estas páginas se hace una breve reseña sobre el libro Geografía y migración: movimientos; territorios y territorialidades, compilado por los profesores Eliseu Savéiro Sposito, Denise Cristina Bomtempo y Adriano Amaro de Sousa y editado por Editora Expressáo Popular en San Pablo, en el año 2010.

  7. Territorio y Poder: La reivindicación territorial de los indígenas de la amazonia boliviana

    Directory of Open Access Journals (Sweden)

    Gabriela Canedo Vásquez

    2011-07-01

    Full Text Available El artículo pretende mostrar la centralidad que tiene el territorio y la demanda territorial para los grupos indígenas de la amazonia boliviana. El territorio tiene un papel importante en la reproducción cultural y en la organización política. La investigación se llevó a cabo en la provincia Mojos del departamento del Beni, y muestra que el manejo territorial itinerante y la percepción del territorio que tenían los grupos indígenas se ha transformado a partir del marco estatal –concretamente desde la ley INRA–. Hoy en día los indígenas demandan títulos de propiedad de los espacios ocupados, ante el avasallamiento de los blancos/karayanas. Es así que aquella concepción ilimitada del territorio, propio de los pueblos panindios, se ha transformado, pues en la actualidad los indígenas perciben un territorio limitado, cercado por propiedades privadas. Sin embargo, el territorio al convertirse en una de las demandas centrales de la organización indígena, es el elemento que les permite posicionarse políticamente en un escenario local y nacional.

  8. Il ponte e Heidegger

    Directory of Open Access Journals (Sweden)

    Pierluigi Giordani

    2012-08-01

    Full Text Available Le considerazioni svolte in questa nota sono un modesto sommario rispetto alle opportunità offerte dal celebre scritto di Martin Heidegger “Costruire, abitare, pensare”. In quelle pagine il ponte (tema del primo numero di “Tria” è l’intrigante simbolo preso come esempio della ”essenza” dell’abitare, intesa come “tratto fondamentale” della condizione umana (abitare come “Sein” dell’uomo.La circostanza menzionata (il contenuto del numero di “Tria” può essere quindi suggerimento e occasione per una ri-cognizione - necessariamente approssimata - del testo di Heidegger. Ricognizione resa indubbiamente più avvincente dalla possibilità di un confronto derivato dall’intervallo temporale fra il climaterio del moderno (in cui è stato redatto lo scritto di Heidegger e il presente.

  9. LE CARATTERISTICHE LINGUISTICHE DELLE DIDASCALIE NELL’ARTE, ANALISI DI UN CASO: IL MUSEO DEL 900 DI MILANO

    Directory of Open Access Journals (Sweden)

    Elena Villa

    2014-07-01

    Full Text Available Il lavoro cerca di sottolineare l’importanza dell’apparato para-testuale che accompagna le opere d’arte; in particolare sono state esaminate la struttura linguistica e le caratteristiche della didascalia. In primo luogo è stata analizzata brevemente la lingua della storia dell’arte, organizzando un’indagine di tipo linguistico condotta secondo quelli che sono considerati i tre livelli di analisi caratteristici delle lingue speciali: il lessico, la morfosintassi e la testualità. In secondo luogo, si è scelto di approfondire le caratteristiche dell’apporto para-testuale, fornendo un’analisi completa della didascalia e alcune notizie di tipo storico. In terzo luogo si sono esaminati casi particolari di didascalie; nello specifico, sono state scelte quelle che accompagnano i dipinti presenti nelle prime cinque sale del Museo del 900 a Milano e sono stati forniti degli esempi concreti a supporto dell’analisi linguistica. Linguistic characteristics of captions in art, a study case: the: Milan’s Museo del 900 (Museum of the Twentieth CenturyElena VillaThe aim of this work was to emphasize the importance of paratextual apparatus with which artworks are presented; in particular, the author analyzed the linguistic structure and the specific characteristics of captions. First of all, in order to briefly analyze the language of art history, linguistic research was conducted. It built on what are considered to be the three main levels of analysis when jargons is concerned: lexicon, morphosyntax and textuality. Secondly, the author chose to examine in depth the characteristics of the paratextual contribution, by making a complete analysis of captions and giving historical information. Thirdly, the author provided concrete examples of captions to support his previous linguistic observation choosing those associated with the paintings of the first five rooms of Milan’s Museo del 900. 

  10. Il teatro degli spiriti.

    Directory of Open Access Journals (Sweden)

    Chiara Pussetti

    2013-07-01

    Full Text Available Questo saggio è dedicato a un culto di possessione, in cui tutte ledonne, investite dagli spiriti degli uomini morti prima dell’iniziazione, compiono un percorso iniziatico parallelo a quello maschile, consentendo a queste anime, potenzialmente pericolose, di completare il cammino che non hanno potuto percorrere da vivi e quindi di raggiungere serenamente il mondo dei morti, come antenati protettori del villaggio

  11. IL-9 by INFERence.

    Science.gov (United States)

    Zhou, Baohua; Kaplan, Mark H

    2013-10-17

    Despite the discovery of the cytokine over 20 years ago, the relevant biological sources of interleukin-9 (IL-9) have remained a mystery. In this issue of Immunity, Licona-Limón et al. (2013) use a newly generated reporter mouse to demonstrate a role for IL-9-secreting T cells in helminthic parasite immunity. Copyright © 2013 Elsevier Inc. All rights reserved.

  12. Assessment of the effects of IL9 , IL9R , IL17A , and IL17F gene ...

    African Journals Online (AJOL)

    Assessment of the effects of IL9 , IL9R , IL17A , and IL17F gene polymorphisms on women with allergic rhinitis in Shahrekord, Iran. ... In the gene–gene interaction analysis, we found that IL9R/IL9 genotype rs731476 T‑/rs2069885 G conferred a higher risk for AR phenotype development. We also did not find a significant ...

  13. Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33 and asthma

    Directory of Open Access Journals (Sweden)

    Rahim Farahani

    2014-01-01

    Full Text Available Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR, mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. It was believed that airway inflammation is orchestrated by allergen specific T helper (Th 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD. Interleukin (IL-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor-α and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33 in asthma. The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well.

  14. Relations Between Serum Essential Fatty Acids, Cytokines (IL-6 & IL ...

    African Journals Online (AJOL)

    The aim of this study was to investigate the relations between free radical generation, interleukins (IL-6 & IL-8), apoptotic marker soluble Fas (sFas), and the level of ... IL-6, IL-8 and sFas whereas serum fatty acid revealed that Linoleicacid (LA) and alpha linolenic acid (ALA) were significantly decreased in the studied cases .

  15. El mito de pristinidad y los usos efectivos del territorio de la región de Magallanes, Patagonia Chilena: Forestal, minería y acuicultura

    Directory of Open Access Journals (Sweden)

    Inostroza, Luis

    2015-06-01

    Full Text Available The current classification methods of land use in remote regions have two serious limitations. The first is the conceptual mixture between land uses and covers, which does not reflect the actual direct use of land. A second limitation is the absence of important uses such as tourism, aquaculture and mining, which impose significant pressures on fragile territories. This paper presents a land use classification method developed specifically for the region of Magellan in the extreme south of Chile. It is a land use classification wide and conceptually clear, which allows an effective determination of the range of land exploitations in Patagonia, determining which areas are used and which remain unused. The method is based entirely on a GIS and is a key input for improving land management. The analysis shows a high percentage of direct use, contrary to the existing pristine perception, which imposes significant challenges for current land management strategies.Los métodos de clasificación de usos del suelo en regiones remotas presentan dos serias limitaciones. La primera es la mixtura conceptual de usos con coberturas que no refleja el uso efectivo del territorio. Una segunda limitación es la ausencia de usos importantes como turismo, acuicultura y minería, que imponen importantes presiones sobre territorios frágiles. Este trabajo presenta un método para determinar los usos territoriales en la región de Magallanes en el extremo austral de Chile. Se trata de una clasificación de usos del suelo elaborada específicamente para este territorio, conceptualmente clara y amplia, que permite establecer el alcance efectivo de las explotaciones territoriales, determinando qué territorios son utilizados y cuales permanecen sin uso. El método está basado íntegramente en un SIG y constituye un insumo clave para mejorar la gestión territorial. El análisis refleja un alto porcentaje de uso directo, contrario a la percepción de pristinidad existente

  16. Il corpo della strega

    Directory of Open Access Journals (Sweden)

    Georges Bertin

    2004-09-01

    Full Text Available Come già evidenziato a proposito di altre pratiche, il sabba, attività ludica profana, religiosa, conferiva a ciascuno la possibilità di giocare efficacemente con la dinamica di un mondo da cui emergeva una figura archetipica, la strega, principale attore di questa danza in tondo. Il sabba era, dunque, uno dei luoghi ove si cristallizzavano le figure del proibito, questo per il suo carattere sacro, per la violenza istituzionale che presiedeva alla formazione dei rapporti sociali, e conferiva anche, per le caratteristiche di protesta che rivela, un'immagine sempre esaltante della capacità delle società a resistere. Il problema della nostra epoca ove rifioriscono le streghe nelle più svariate forme è, forse, quello di riallacciarsi con la dimensione gruppale dei nostri svaghi, nelle loro differenti forme e, contemporaneamente, con perdita di energia, a quanto presiedeva ai sabba e alla loro risoluzione sacrificale. In contro-corrente ai modelli meccanici che assegnano dei limiti precisi e funzionali ai corpi asserviti ad un ideale di controllo, il corpo sabbatico con la sua enfasi sulle posizioni limite (ciò che si rimproverava d'altronde alle streghe, era veramente corpo mistico.

  17. Multiple lipopolysaccharide (LPS) injections alter interleukin 6 (IL-6), IL-7, IL-10 and IL-6 and IL-7 receptor mRNA in CNS and spleen.

    Science.gov (United States)

    Szot, Patricia; Franklin, Allyn; Figlewicz, Dianne P; Beuca, Timothy Petru; Bullock, Kristin; Hansen, Kim; Banks, William A; Raskind, Murray A; Peskind, Elaine R

    2017-07-04

    Neuroinflammation is proposed to be an important component in the development of several central nervous system (CNS) disorders including depression, Alzheimer's disease, Parkinson's disease, and traumatic brain injury. However, exactly how neuroinflammation leads to, or contributes to, these central disorders is unclear. The objective of the study was to examine and compare the expression of mRNAs for interleukin-6 (IL-6), IL-7, IL-10 and the receptors for IL-6 (IL-6R) and IL-7 (IL-7R) using in situ hybridization in discrete brain regions and in the spleen after multiple injections of 3mg/kg lipopolysaccharide (LPS), a model of neuroinflammation. In the spleen, LPS significantly elevated IL-6 mRNA expression, then IL-10 mRNA, with no effect on IL-7 or IL-7R mRNA, while significantly decreasing IL-6R mRNA expression. In the CNS, LPS administration had the greatest effect on IL-6 and IL-6R mRNA. LPS increased IL-6 mRNA expression only in non-neuronal cells throughout the brain, but significantly elevated IL-6R mRNA in neuronal populations, where observed, except the cerebellum. LPS resulted in variable effects on IL-10 mRNA, and had no effect on IL-7 or IL-7R mRNA expression. These studies indicate that LPS-induced neuroinflammation has substantial but variable effects on the regional and cellular patterns of CNS IL-6, IL-7 and IL-10, and for IL-6R and IL-7R mRNA expression. It is apparent that administration of LPS can affect non-neuronal and neuronal cells in the brain. Further research is required to determine how CNS inflammatory changes associated with IL-6, IL-10 and IL-6R could in turn contribute to the development of CNS neurological disorders. Published by Elsevier Ltd.

  18. IL web tutorials

    DEFF Research Database (Denmark)

    Hyldegård, Jette; Lund, Haakon

    2012-01-01

    The paper presents the results from a study on information literacy in a higher education (HE) context based on a larger research project evaluating 3 Norwegian IL web tutorials at 6 universities and colleges in Norway. The aim was to evaluate how the 3 web tutorials served students’ information...... seeking and writing process in an study context and to identify barriers to the employment and use of the IL web tutorials, hence to the underlying information literacy intentions by the developer. Both qualitative and quantitative methods were employed. A clear mismatch was found between intention...... and use of the web tutorials. In addition, usability only played a minor role compared to relevance. It is concluded that the positive expectations of the IL web tutorials tend to be overrated by the developers. Suggestions for further research are presented....

  19. HÁBITAT Y TERRITORIO: COHERENCIA PARA EL ORDENAMIENTO TERRITORIAL. EL CASO DE LA PROVINCIA DE COLCHAGUA, CHILE

    Directory of Open Access Journals (Sweden)

    Ninoska Lamilla

    2010-01-01

    Full Text Available Requiriéndose en Chile de un ordenamiento territorial que armonice los distintos usos del territorio, carecemos de éste. La división político - administrativa no contribuye en esta tarea, y los Instrumentos de Planificación Territorial (IPT llevados a cabo responden fundamentalmente a requerimientos sectoriales. Se extraña un eje conductor de los diferentes instrumentos sectoriales que regule los usos del territorio. Esto aunque en la actualidad, para hacer una aproximación sustentable, se sugiere que son los territorios y no los productos los que compiten en los mercados. La idea de constatar la efectividad del enfoque planificador de abajo hacia arriba, valoriza la participación de los actores y sus características con los territorios en que se desarrollan, tanto privados como públicos. Esto se llevó a cabo en Colchagua, y ha permitido lograr un ordenamiento territorial sustentable, aún careciendo de un marco normativo, y sólo gracias a intervenciones sectoriales con perspectiva territorial. Para validar lo señalado hemos revisado ejemplos interesantes por sus fortalezas, dado que reconocen las características, las identidades y los actores de los territorios, como lo han sido los programas "Smartland" y "Leader+", los cuales de cierta manera nos hacen comprender lo que se ha producido en el ordenamiento del valle de Colchagua.

  20. Il Servizio Intercultura dell’Istituto di Terapia Familiare di Firenze

    Directory of Open Access Journals (Sweden)

    Giancarlo Francini

    2013-12-01

    Full Text Available Nel corso del presente articolo vengono descritte le premesse epistemologiche e le metodologie adottate dagli operatori del Servizio Intercultura dell’Istituto di Terapia Familiare di Firenze (ITFF nel lavoro con la popolazione migrante ed elencati gli interventi fatti nel territorio. Il Servizio Intercultura dell’ITFF si è interrogato in questi anni sul valore della cultura come porta d’ingresso nel rapporto con il migrante; nel chiedere loro di narrare aspetti della loro cultura condividiamo aspetti della nostra cultura. L’incontro con il malinteso, che come dice Jankelevitch «(… è un quasi niente» (Jankelevitch, 1987, p. 233, perché se fosse stato qualcosa di più ce ne saremmo accorti e se fosse qualcosa di meno non sarebbe significativo, ci permette di aprirci a un rapporto che cambia entrambi, operatore e migrante, nella relazione. È nella relazione e attraverso il racconto dell’evento migrazione e del ciclo di vita che si costruisce e si cerca un linguaggio comune per la descrizione e l’espressione del disagio. Il lavoro con i migranti deve fare i conti con le difficoltà legate all’impiego, alla casa, al permesso di soggiorno e non ultimo alla brevità di alcuni incontri, perché per alcuni la nostra città è solo una tappa di un percorso che continua alla ricerca di una sistemazione migliore. Nel territorio di Firenze sono stati messi a punto una serie di servizi: oltre alla clinica e a uno sportello di consulenza, ci si dedica alla formazione degli operatori che lavorano con i migranti. Esempi di queste attività sono: un progetto di peer tutoring in alcune scuole superiori, uno di formazione per le assistenti sociali al fine di proporre un protocollo più efficace di presa in carico dei migranti, una serie di focus group con dipendenti Asl all’interno del progetto “Mamma segreta” della regione Toscana; inoltre, la collaborazione con le associazioni presenti sul territorio ha permesso un contatto

  1. Identidades del territorio Alhambra. Instrumentos de registro y procesos de reconocimiento de un paisaje cultural

    Directory of Open Access Journals (Sweden)

    Juan Domingo Santos

    2017-11-01

    Full Text Available En el proceso de revitalización de los paisajes culturales se plantea la necesidad de contar con un sistema de registro documental del territorio que implique diferentes técnicas y formas de aproximación para la comprensión de sus características e identidades. Esta investigación propone una serie de medidas para registrar, analizar y divulgar los valores culturales de la Dehesa del Generalife, un territorio en continuidad con el conjunto monumental de la Alhambra, muy rico por sus recursos arqueológicos, arquitectónicos, paisajísticos, medioambientales y etnológicos, que configuran un espacio de incuestionable valor cultural. La metodología de trabajo supone una estrategia de conocimiento sensible para detectar y dilucidar soluciones de preservación y mantenimiento en lugares de un alto interés patrimonial. La noción de “paisaje cultural” está tratada como un concepto amplio basado en la percepción antropológica del territorio que incluye el valor histórico, cultural y simbólico de los elementos visibles que componen un paisaje y sus relaciones. La investigación parte de la premisa del Plan Director Alhambra que propone una revisión de los conocimientos actuales del monumento desde una perspectiva territorial que supera la idea tradicional de la Alhambra como una ciudad palatina rodeada de murallas para ser entendida en su contexto territorial.

  2. Il Fedone di Platone

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2015-01-01

    Full Text Available Nei colloqui precedenti si erano toccate molte opinioni filosofiche sbagliate, e allora Socrate dice: “Sarebbe ben comprensibile se uno, a motivo dell’irritazione per tante cose sbagliate, per il resto della sua vita prendesse in odio ogni discorso sull’essere e lo...

  3. Helping You Buy ILS

    Science.gov (United States)

    Cibbarelli, Pamela R.

    2010-01-01

    This article is the fourth in a series of articles published annually by "Computers in Libraries" surveying integrated library systems and services (ILSs). The purpose of the annual survey is to enable comparison of the ILSs that are available. ILS vendors are in constant pursuit of an ever-changing, consistently vague definition of what the…

  4. Il dono del racconto

    DEFF Research Database (Denmark)

    Polito, Paola

    1998-01-01

    'importanza assunta nel romanzo dal piano dell'enunciazione come luogo privilegiato di manifestazione del soggetto quale esperiente una vicenda di maturazione. Il protagonista, qui, non solo si rappresenta in ciò che enuncia e riferisce, ma anche e soprattutto si svela nelle modalità specifiche del proprio discorso...

  5. Il pericolo degli ebook

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2014-01-01

    Full Text Available I libri stampati: si possono acquistare anonimamente in contanti; quindi se ne è proprietari: non dobbiamo firmare una licenza che ne restringe l’uso: il loro formato è noto e per leggerli non occorrono tecnologie proprietarie; si possono dare, prestare o...

  6. Tratamiento fisioterapico en pacientes con lesión en territorio de la arteria cerebral media.

    OpenAIRE

    Bays Moneo, Ana Beatriz

    2014-01-01

    Paciente de 70 años que padece una hemiparesia derecha con afasia de Broca de casi dos años de evolución como consecuencia de una oclusión de arteria carótida interna que provocó un infarto en el territorio de la arteria cerebral media. Para su tratamiento se ha utilizado el concepto Bobath. Durante el mismo, tuvo una frecuencia de tres sesiones por semana de 45 minutos durante cuatro meses. El paciente mostraba como problema principal, un pie con gran tendencia al equ...

  7. Diabetes y su impacto en el territorio periodontal Diabetes and its impact in periodontal tissues

    OpenAIRE

    P Smith; I Retamal; M Cáceres; A Romero; D Silva; R Arancibia; C Martínez

    2012-01-01

    Diabetes y enfermedad periodontal corresponden probablemente al mejor ejemplo de cómo una enfermedad sistémica puede tener un efecto en el territorio periodontal. Si bien esta asociación ha sido extensamente estudiada, muchas de las asociaciones propuestas presentan contradicciones. En la presente revisión de la literatura se analizan los siguientes tópicos relevantes para la práctica clínica en periodoncia e implantología: i) Identificación de enfermedad periodontal severa y su capacidad par...

  8. El Ministerio de Fomento, impulsor del estudio y el reconocimiento del territorio mexicano (1877-1898

    Directory of Open Access Journals (Sweden)

    MIreya Blanco Martínez

    2012-02-01

    Full Text Available El objetivo de este artículo es dar a conocer una serie de reflexiones acerca del papel que desempeñó el Ministerio de Fomento en torno al estudio y reconocimiento del territorio mexicano en la segunda mitad del siglo XIX, esto se sustentará en el análisis de los informes contenidos en una de las publicaciones del Ministerio de Fomento: los Anales del Ministerio de Fomento de la República Mexicana, correspondiendo el periodo delimitado para esta investigación con el de la publicación de Anales.

  9. TURISMO CULTURAL: PATRIMONIO, IDENTIDAD, TERRITORIOS Y SUSTENTABILIDAD UNA MIRADA DESDE LAS CIENCIAS DE LA COMPLEJIDAD

    Directory of Open Access Journals (Sweden)

    Eduardo Forero Lloreda

    2013-07-01

    Full Text Available El objetivo de esta presentación es llamar la atención sobre el papel preponderante de la investigación arqueológica como agente visualizador de recursos culturales y turísticos. De igual forma, la implementación de herramientas teóricas que facilitan el ejercicio de una arqueología transdis-ciplinaria, sustentable y dialógica, cuyo propósito es la integración de territorios y comunida-des. Argumentación hecha desde las ciencias de la complejidad.

  10. Espacio y territorios: razón, pasión e imaginarios

    OpenAIRE

    Delgado Mahecha, Ovidio; Moncayo, Édgar; Jiménez Reyes, Luis Carlos; Carrizosa Umaña, Julio; Osorio, Laura Cecilia; Escobar R., Iván; Gaviria, Sergio; Lucio, Julián Arturo; Seygundiwa Quigua, Ati; Jacanamijoy Tisoy, Benjamín; Mesa Sánchez, Nora Elena; Echeverría Ramírez, María Clara; Barrera, Susana; Banda, Alexandro; Cuevas, Óscar

    2001-01-01

    En este caleidoscopio de acercamientos hacia lo espacial y territorial, las visiones se mueven desde aquellas románticas y existencialistas, pasando por aquellas objetivistas y positivistas, hasta las estructuralistas y postestructuralistas. Por el espacio y el territorio se interesan con enfoques diversos numerosas disciplinas, desde la psicología, la etología o la literatura, y las ciencias naturales como la biología o la ecología, hasta las ciencias sociales y políticas, como la geografía,...

  11. Sociedad y sequía en un territorio insular (El Hierro, Canarias).

    OpenAIRE

    Martín Fernández, Carlos Santiago

    2009-01-01

    Por motivos socioeconómicos, la isla de El Hierro (Islas Canarias) ha sido considerada como un territorio marginado, “la Cenicienta del archipiélago canario” para algunos autores. Esta opinión se ha basado en un modelo interpretativo de su atraso socioeconómico centrado de manera preferente en la falta de agua, más en concreto en la impo­sibilidad de proveerse de agua de lluvia o sequía climática. Esta particular versión hídrica de sus males se matiza, en algunas interpretaciones, con el añad...

  12. SCAN&GO Il nuovo modo di fare Topografia

    Directory of Open Access Journals (Sweden)

    SCAN&GO S.R.L.

    2013-04-01

    Full Text Available L’articolo propone una nuova metodologia per il rilievotopografico del territorio che utilizza strumentazione laserscanner abbinata a ricevitori GPS. Il sistema, installato su autoveicolo in modalità “Rileva e Vai”, è studiato perottenere una definizione tridimensionale centimetrica disingole scansioni in un unico sistema di riferimento.Scan&Go is a new method for the topographical survey of the area using laser scanner combined with GPS receivers.The system, installed on vehicle mode "Detect and Go" (Patent Pending is designed to obtain a three-dimensional definition centimeter of individual scans into a single reference system.This methodology arises from the need to make faster and more productive use of the new systems terrestrial laser scanner in the field of traditional survey, stimulating the transition from the method of timely relief to that of the three-dimensional virtual reality allowing its use also in daily Topography classic.

  13. IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling.

    Science.gov (United States)

    Floss, D M; Schönberg, M; Franke, M; Horstmeier, F C; Engelowski, E; Schneider, A; Rosenfeldt, E M; Scheller, J

    2017-11-09

    IL-35 and IL-39 are recently discovered shared members of the IL-6- and IL-12-type cytokine family with immune-suppressive capacity. IL-35 has been reported to induce the formation of four different receptor complexes: gp130:IL-12β2, gp130:gp130, IL-12β2:IL-12β2, and IL-12β2:WSX-1. IL-39 was proposed to form a gp130:IL-23R receptor complex. IL-35, but not IL-39, has been reported to activate non-conventional STAT signaling, depending on the receptor complex and target cell. Analyses of IL-35 and IL-39 are, however, hampered by the lack of biologically active recombinant IL-35 and IL-39 proteins. Therefore, we engineered chimeric cytokine receptors to accomplish synthetic IL-35 and IL- 39 signaling by shuffling the extra- and intracellular domains of IL-6/IL-12-type cytokine receptors, resulting in biological activity for all previously described IL-35 receptor complexes. Moreover, we found that the proposed IL-39 receptor complex is biologically active and discovered two additional biologically active synthetic receptor combinations, gp130/IL-12Rβ1 and IL-23R/IL-12Rβ2. Surprisingly, synthetic IL-35 activation led to more canonical STAT signaling of all receptor complexes. In summary, our receptor shuffling approach highlights an interchangeable, modular domain structure among IL-6- and IL-12-type cytokine receptors and enabled synthetic IL-35 and IL-39 signaling.

  14. Reti di città, mobilità e ambiente: il Preliminare di PTCP di Avellino

    Directory of Open Access Journals (Sweden)

    Carmela Gargiulo

    2010-02-01

    Full Text Available  L’articolo propone la lettura dei contenuti del Preliminare del PTCP di Avellino, un piano per molti aspetti innovativo, soprattutto per aver coniugato pianificazione di area vasta di tipo tradizionale e logica “strategica”. In particolare, l’articolo descrive idee guida, contenuti e strategie del piano orientate, prevalentemente, a stimolare lo sviluppo sostenibile di un’area in ritardo di sviluppo come la provincia irpina, attraverso la salvaguardia e valorizzazione delle risorse naturali e storico-culturali, la costruzione di reti di medie e piccole città e reti di mobilità alle diverse scale, da quella urbana a quella internazionale, e interventi sul sistema della mobilità. Nel 2004, ormai più di cinque anni fa, è stato adottato, a maggioranza assoluta (solo due gli astenuti, il Preliminare di Piano Territoriale di Coordinamento della Provincia di Avellino, dopo un lavoro di oltre due anni che ha visto impegnati gli uffici provinciali con due dipartimenti universitari. Il lavoro, che va ben oltre il significato e la valenza di un preliminare e che coniuga due pratiche di piano diverse (quella tradizionale e quella strategica ruota attorno a tre idee di fondo, tra loro strettamente interrelate, che costituiscono i criteri guida che finora ha inteso seguire la provincia di Avellino nell’attività di governo delle trasformazioni. Tali idee, quindi, costituiscono le fondamenta su cui è stato costruito il Preliminare e sono la griglia di specificazione delle strategie e degli obiettivi di piano. Esse sono alla base delle scelte elaborate per lo sviluppo compatibile del territorio, e sono riferibili alle azioni operative di trasformazione del territorio che gli Enti locali, cui è demandato tale compito, nel prossimo futuro dovranno affrontare. Le tre idee forza del Preliminare, descritte nel seguito, sono riferibili ai sistemi di risorse principali della provincia di Avellino, oggetto di una indagine analitico

  15. Productividad local y reconversión de infraestructura hacia un territorio industrial sostenible: Canadá-Colombia

    Directory of Open Access Journals (Sweden)

    Adriana P. López-Valencia

    2013-08-01

    Full Text Available Este texto aborda el análisis de dos casos sobre la consoli­dación de nueva infraestructura en territorios industriales. El primero, trata la reconversión de infraestructura indus­trial en espacios intraurbanos de Montreal-Quebec, Cana­dá, generada durante el proceso de mejoramiento tecnoló­gico propiciado por el tránsito de la sociedad-industrial a la sociedad del conocimiento. Asimismo, se identificaron estrategias de estructuración local del territorio que reco­nocen el papel de cada actor en la construcción de iden­tidad, bajo modelos productivos sostenibles. El segundo caso, se concentra en estudiar la consolidación de infraes­tructura industrial en Yumbo-Valle, Colombia, sugiriendo estrategias locales para lograr el éxito en su incorporación como un territorio sostenible.

  16. Territorio Mutis

    Directory of Open Access Journals (Sweden)

    Juan Gustavo Cobo Borda

    2005-05-01

    Full Text Available La altiplanicie donde se halla situada la sabana de Bogotá, a 2.600 metros sobre el nivel del mar, tiene un cielo despejado que vuelve aún más verde el oscuro marco de sus montañas. Pero al tomar la carretera que lleva a tierra caliente, y pasar por el salto de Tequendama, las curvas del camino producen una sensación ambigua de mareo y asombro. De paulatino despojarse de suéteres y chaquetas e incremento, en la piel, en los ojos, de tibieza y vértigo. Pasamos bajo las gárgolas góticas talladas en milenarias piedras chibchas y nos asomamos, con el corazón en la boca, a los abismos más insondables. Allí abajo, muy abajo, casi invisible, un delgado hilo de plata nos recuerda que las cordilleras más empinadas pueden resultar horadadas por el diamante líquido del agua.

  17. Il nucleo terrestre: il cuore magnetico della Terra

    OpenAIRE

    De Santis, A.

    2006-01-01

    Il campo magnetico terrestre è una proprietà intrinseca del nostro pianeta e di altri oggetti del sistema solare. Il Sole stesso possiede un forte campo magnetico che si inverte quasi ciclicamente ogni 10-11 anni; tale comportamento è visibile attraverso la medesima ciclicità delle macchie solari che denotano sulla superficie l’intensa attività magnetica della nostra stella. Il campo magnetico terrestre è importantissimo per la vita sulla Terra. Esso protegge il pianeta dalle p...

  18. Arquitectura en territorios informados y transparentes Una wiki en la escuela de arquitectura

    Directory of Open Access Journals (Sweden)

    Javier Fernández García

    2010-01-01

    Full Text Available El marco general de nuestra investigación en la universidad son los espacios de convivencia, información y formación que configuran los habitantes en un territorio online. La Web 2.0 nos ha dotado de nuevas herramientas con la que construir espacios. Desde la fundación en agosto de 2006 de CityWiki, indagamos en la arquitectura de estos lugares que se articulan en un espacio común en el que, a falta de jerarquía y policía, la acción en él la define el empoderamiento y la libertad del ciudadano responsable. A modo de laboratorio, desde entonces, embarcamos la actividad investigadora y docente en la actitud 2.0 incluida en la WWW. En la primera parte de este artículo se expone el pensamiento actualizado que empíricamente evoluciona emparejado a la actualidad de nuestras investigaciones. El objetivo es hacer entender el territorio wiki como informado y transparente llamado a añadir capas de información a la realidad para de esta forma no sustituirla sino ampliarla. Seguidamente, en la segunda parte, se describe y analiza la experiencia de innovación llevada a cabo durante el curso 2007/2008 en la que se ensayó un modelo docente instrumentados en los modos y paisajes previamente descritos.

  19. Reflexiones sobre los territorios de la espacialidad turística

    Directory of Open Access Journals (Sweden)

    Francisco Fernando Beltrán Valcárcel

    2015-04-01

    Full Text Available El souvenir, cuya máxima expresión es la bola de nieve o snow globe, pequeños mundos cerrados y en miniatura que encapsulan la experiencia real, trata de satisfacer el anhelo nostálgico del turista, nos muestra una imagen sintética de un espacio geográfico congelado. Sin embargo, el territorio que reduce y caricaturiza se encuentra muy lejos de ese estado, se halla en ebullición. Los territorios de la espacialidad turística experimentan profundas transformaciones y mutaciones cuando son alcanzados por las dinámicas insostenibles del turismo de masas. Y las ciudades, como máxima expresión de las sociedades, dan cuenta de estos complejos procesos, compitiendo a escala global para posicionarse como destinos, convirtiéndose en parques temáticos, paisajes urbanos banalizados y que han visto adulterados su carácter y fisionomía de manera irreversible.

  20. de Granada y plan de ordenación del territorio

    Directory of Open Access Journals (Sweden)

    J. A. Cañete Pérez

    2005-01-01

    Full Text Available Las Aglomeraciones Urbanas de las capitales andaluzas constituyen, junto con las áreas litorales, los espacios más dinámicos de la Comunidad Autónoma de Andalucía, donde se concentra gran parte de la población y las actividades económicas. Son espacios con una gran complejidad funcional que han requerido una especial atención de la administración en cuanto a la planificación de las infraestructuras y los usos del suelo, como prueban los Planes de Ordenación del Territorio de Ámbito Subregional formulados sobre estos espacios a lo largo de la década de los años noventa. A lo largo del presente articulo se comparan los datos demográficos correspondientes a la evolución reciente de los municipios de la Aglomeración Urbana de Granada con las previsiones que estableció el Plan de Ordenación del Territorio para dicho ámbito, con el objeto de constatar el grado de adecuación de la planificación a las últimas tendencias demográficas detectadas. Se analiza de esta forma la vigencia del modelo territorial previsto por la Planificación Territorial.

  1. Pueblos indígenas, Estado y Territorio en tiempos interculturales en la provincia de Salta

    Directory of Open Access Journals (Sweden)

    Mariana Andrea Schmidt

    2011-12-01

    Full Text Available La configuración del Estado argentino hacia fines del siglo XIX y principios del XX tuvo como uno de sus móviles principales la eliminación, asimilación e invisibilización de los pueblos indígenas. En las últimas décadas del siglo XX, se ha pasado de una política de invisibilización y homogeneización a otra de visibilización y reconocimiento de la diversidad cultural, promoviéndose la diversidad territorial, cultural y lingüística acallada durante décadas. El objetivo del presente artículo es indagar en las características asumidas por estos procesos en la provincia de Salta. Partiendo de considerar al Chaco salteño como territorio históricamente imaginado como indígena, interesa pensar cómo juegan estos imaginarios territoriales a la hora de diseñar e implementar políticas públicas para este territorio y su población.

  2. Ordenación… o desordenamiento del territorio y el papel de la universidad: ¿claroscuro o reto…?

    OpenAIRE

    Carrasco Aquino, Roque Juan; Calderón, Hena Andrés

    2011-01-01

    Plantear de manera sucinta, un desarrollo sobre la transformación del territorio de las ciudades mineras que, del México minero del siglo pasado, tuvieron influencias en la desordenación territorial, y comprender la traza urbana del presente. Asimismo, analizar las tendencias que ha seguido la ordenación del territorio como una expresión física espacial de las políticas del Estado Mexicano y sus consecuencias desestructurantes en los diferentes ámbitos de la política, en la economía, en lo so...

  3. Los patronatos pro educación en el Territorio Norte de la Baja California, 1945-1952

    OpenAIRE

    María del Rosario Maríñez

    2010-01-01

    Durante el período de gobierno del presidente Manuel Ávila Camacho (1940-1946) se emprendió un proyecto de federalización educativa centralizada que incorporó a los territorios federales; como respuesta a esa acción gubernamental fueron creados los patronatos pro educación en el Territorio Norte de la Baja California durante el período presidencial de Miguel Alemán Valdés (1946-1952) por parte del gobierno territorial, de la iniciativa privada y funcionarios federales educativos, para tratar ...

  4. Il nuovo ortofotopiano del Comune di Venezia nell’Infrastruttura dei dati Territoriali di Base (ITB

    Directory of Open Access Journals (Sweden)

    Paolo Barbieri

    2006-06-01

    Full Text Available Il Comune di Venezia, nell’ambito delle attività per lo sviluppo del proprio Sistema Informativo Territoriale, ha messo a punto e avviato a realizzazione uno specifico progetto per la costruzione di un’Infrastruttura di dati Territoriali di Base (ITB. Il progetto, che ha visto il coinvolgimento dei vari Uffici comunali interessati, dellaRegione del Veneto e dell’Agenzia del Territorio, si è sviluppato a partire dal 2002 con gli studi di fattibilità, cui è seguita nel 2003 la fase della progettazione esecutiva e quindi, a partire dal 2004, dell’attuazione. Attualmente le componenti dell’infrastruttura sono state realizzate e si sta procedendo alla definizione di una piattaforma tecnologica per la gestione e l’utilizzo della ITB, basata su di un Geo-DBMS e meccanismi di interoperabilità, con l’obiettivo di interfacciare le diverse applicazioni gestionali presenti in Comune. Nel presente articolo si intende presentare il modello concettuale di riferimento ed evidenziare, in particolare, il ruolo in esso svolto dalle immagini ortofotografiche.

  5. Il libro di fisica

    CERN Document Server

    Asimov, Isaac

    1986-01-01

    Isaac Asimov, illustre studioso e brillante divulgatore scientifico, ma anche grandissimo scrittore di science fiction, ha costruito questa volta una vera e propria «biografia delle scienze fisiche». Il presente volume, che nel mondo anglosassone è diventato una «bibbia della fisica», ci introduce, in forma semplice ma rigorosa, ai segreti dei quasar e dei buchi neri, dei quark e degli acceleratori di particelle, dell'intelligenza artificiale e delle fonti di energia, sia essa quella «sporca» sia quella «pulita». Un vero, completo manuale, ma anche un «romanzo» affascinante sia per il profano sia per l'uomo di scienza.

  6. Il maxiprocesso di Palermo

    Directory of Open Access Journals (Sweden)

    A cura di Sarah Mazzenzana

    2016-04-01

    La Torre. La “Rivista” ripubblica qui alcuni stralci dell’ordinanza di rinvio a giudizio, alla quale Giovanni Falcone e Paolo Borsellino attesero, per ragioni di sicurezza, rifugiati nell’isola dell’Asinara. Viene ricostruita la realtà disvelata dai racconti di Leonardo Vitale, di Giuseppe Di Cristina e soprattutto di Tommaso Buscetta e Salvatore Contorno. Sono brani che, anche riletti oggi, mantengono una propria potenza narrativa, perfino una certa solennità. Il Maxiprocesso si sarebbe chiuso dopo alterne vicende, il 30 gennaio del 1992, con la condanna all’ergastolo in Cassazione della cosiddetta Cupola di Cosa nostra. Per la prima volta in centotrent’anni di storia nazionale i boss mafiosi avrebbero conosciuto la condanna a vita in via definitiva. Dopo pochi mesi avrebbero risposto con le stragi, uccidendo platealmente i due principali estensori dell’ordinanza.

  7. IL21R

    Science.gov (United States)

    Bolzoni, Marina; Ronchetti, Domenica; Storti, Paola; Donofrio, Gaetano; Marchica, Valentina; Costa, Federica; Agnelli, Luca; Toscani, Denise; Vescovini, Rosanna; Todoerti, Katia; Bonomini, Sabrina; Sammarelli, Gabriella; Vecchi, Andrea; Guasco, Daniela; Accardi, Fabrizio; Palma, Benedetta Dalla; Gamberi, Barbara; Ferrari, Carlo; Neri, Antonino; Aversa, Franco; Giuliani, Nicola

    2017-04-01

    Bone marrow monocytes are primarily committed to osteoclast formation. It is, however, unknown whether potential primary alterations are specifically present in bone marrow monocytes from patients with multiple myeloma, smoldering myeloma or monoclonal gammopathy of undetermined significance. We analyzed the immunophenotypic and transcriptional profiles of bone marrow CD14 + monocytes in a cohort of patients with different types of monoclonal gammopathies to identify alterations involved in myeloma-enhanced osteoclastogenesis. The number of bone marrow CD14 + CD16 + cells was higher in patients with active myeloma than in those with smoldering myeloma or monoclonal gammopathy of undetermined significance. Interestingly, sorted bone marrow CD14 + CD16 + cells from myeloma patients were more pro-osteoclastogenic than CD14 + CD16-cells in cultures ex vivo Moreover, transcriptional analysis demonstrated that bone marrow CD14 + cells from patients with multiple myeloma (but neither monoclonal gammopathy of undetermined significance nor smoldering myeloma) significantly upregulated genes involved in osteoclast formation, including IL21R IL21R mRNA over-expression by bone marrow CD14 + cells was independent of the presence of interleukin-21. Consistently, interleukin-21 production by T cells as well as levels of interleukin-21 in the bone marrow were not significantly different among monoclonal gammopathies. Thereafter, we showed that IL21R over-expression in CD14 + cells increased osteoclast formation. Consistently, interleukin-21 receptor signaling inhibition by Janex 1 suppressed osteoclast differentiation from bone marrow CD14 + cells of myeloma patients. Our results indicate that bone marrow monocytes from multiple myeloma patients show distinct features compared to those from patients with indolent monoclonal gammopathies, supporting the role of IL21R over-expression by bone marrow CD14 + cells in enhanced osteoclast formation. Copyright© Ferrata Storti Foundation.

  8. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans

    DEFF Research Database (Denmark)

    Steensberg, Adam; Fischer, Christian Philip; Keller, Charlotte

    2003-01-01

    The purpose of the present study was to test the hypothesis that a transient increase in plasma IL-6 induces an anti-inflammatory environment in humans. Therefore, young healthy volunteers received a low dose of recombinant human (rh)IL-6 or saline for 3 h. Plasma IL-6 levels during rhIL-6 infusion...... number without effects on plasma epinephrine, body temperature, mean arterial pressure, or heart rate. In conclusion, this study demonstrates that physiological concentrations of IL-6 induce an anti-inflammatory rather than an inflammatory response in humans and that IL-6, independently of TNF......-induced leukocyte trafficking....

  9. Trasformazione urbana verso la mobilità dolce: il caso di Istanbul

    Directory of Open Access Journals (Sweden)

    Emilia Giovanna Trifiletti

    2008-12-01

    Full Text Available Nell’articolo si descrivono le recenti trasformazioni urbane della città di Istanbul in Turchia in relazione all’implementazione di aree pedonali e all’utilizzo di mobilità dolce. Il sistema trasportistico è stato ampliato ed integrato di recente ed in tempi molto brevi: nei soli ultimi due anni è stata potenziata la linea tranviaria, sono state inaugurate una funicolare ed una teleferica ed è stata realizzata una stazione di interscambio gomma-ferro, ponendo grande attenzione all’integrazione del trasporto su ferro e/o gomma con la mobilità pedonale. Allo stesso modo sono state implementate le linee marittime che collegano le diverse sponde della città ed integrate alle linee su ferro e su gomma. Lo sviluppo e la riqualificazione della città sono dunque stati guidati dalla trasformazione del sistema trasportistico che ha rappresentato il vero motore della riqualificazione urbana. L’antico quartiere di Sultanahmet è stato interamente riqualificato e collegato, attraverso la linea tranviaria veloce che lo attraversa interamente, al resto della città fino ai quartieri più periferici. Allo stesso modo nel quartiere di Beyoglu che, dopo l’indipendenza era caduto in totale rovina, ha riacquistato l’antica eleganza che lo connotava. Il viale dell’Indipendenza (antica Rue De Pera che attraversa tutto il quartiere è stato reso pedonale e con un tram vintage che percorre tutto il viale sono stati collegati il nodo di interscambio Taksim, dotato di metropolitana e funicolare, con il nodo di interscambio Tünel, dotato di tram veloce e trasporto su gomma. Nell’articolo si è inteso evidenziare come la riqualificazione urbana della città sia stata guidata da interventi integrati trasporto/territorio e come i risultati ottenuti, nel caso-studio, siano stati anche il frutto di politiche attente alla sicurezza sociale.

  10. Ugo Spirito e il pragmatismo

    OpenAIRE

    Restanio, Franco

    2000-01-01

    Quando appare, nel 1921 presso Vallecchi di Firenze, la prima opera di Ugo Spirito, Il pragmatismo nella filosofia contemporanea, la fugace meteora del pragmatismo in versione italiana è ormai un ricordo sbiadito. Quello che viene considerato il rappresentante massimo, o almeno il più seriamente preparato, di quella meteora, Giovanni Vailati è morto nel1909, all'età di quarantasei aimi. Qualche anno dopo, nel 1914, lo segue, ancora più prematuramente, il collaboratore a lui più...

  11. Cesare Lombroso: il misoneismo e il martirio del folle

    OpenAIRE

    Bertani, Stefano

    2007-01-01

    Il testo illustra, attraversando alcuni dei più noti luoghi della patologia criminale e della devianza lombrosiana, il nesso fra la teoria del folle e il suo rapporto con il male, considerato uno dei punti più dibattuti di tutta la cultura dell’età del progresso. A dispetto dei lunghi anni d’oblio e soprattutto degli stereotipi con cui la figura e l’opera di Cesare Lombroso hanno attraversato il XX secolo, tornare a riflettere su di essi giova ad una miglior comprensione storica, facendo luce...

  12. IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes

    Directory of Open Access Journals (Sweden)

    Hisako Hayashi

    2014-01-01

    Full Text Available Interleukin-33 appears to play important roles in the induction of allergic airway inflammation. However, whether IL-33 is involved in airway remodeling remains unclear. Because fibrocytes contribute to tissue remodeling in the setting of chronic inflammation, we examined the effects of IL-33 on fibrocyte functions. Fibrocytes were generated in vitro from peripheral blood mononuclear cells by culturing in the presence of platelet derived growth factors and the cells were stimulated with IL-33. IL-33 enhanced cell proliferation, α-SMA expression, and pro-MMP-9 activity by the fibrocytes without increasing endogenous transforming growth factor-β1 production. Fibrocytes constitutively expressed IL-13 and IL-5, and their production was augmented by stimulation with IL-33. Dexamethasone inhibited the functions of fibrocytes, but IL-33 made fibrocytes slightly refractory to the inhibitory effect of dexamethasone in terms of IL-13 production. Montelukast suppressed IL-13 production by nonstimulated fibrocytes but not those stimulated by IL-33. These findings suggest that IL-33 is involved in the airway remodeling process through its modulation of fibrocyte function independent of antigen stimulation. IL-33 might partially reduce the therapeutic effects of glucocorticoid and cysteinyl leukotriene receptor antagonist on fibrocyte-mediated Th2 responses.

  13. Multifuncionalidad agraria y territorio: Algunas reflexiones y propuestas de análisis

    Directory of Open Access Journals (Sweden)

    Rocío Silva Pérez

    2010-12-01

    Full Text Available La aplicación a la agricultura del concepto de sostenibilidad conlleva el reconocimiento de que, conjuntamente con la función productiva, ésta desempeña otros roles (ambientales, sociales, patrimoniales cada vez más demandados y estrechamente relacionados con su sustrato territorial. La noción de multifuncionalidad agraria lo recoge expresamente y así se sobreentiende desde otros marcos conceptuales y normativos, hasta ahora ajenos al sector, pero cada vez más interesados por los espacios de cultivo como estructurantes territoriales, depositarios de recursos patrimoniales y paisajes. Sus entendimientos del territorio son, no obstante, muy diferentes, sus escalas de análisis extremadamente dispares y sus implicaciones normativas -ora sectoriales, ora territoriales- contradictorias y redundantes. Este artículo se acerca a la multifuncionalidad agraria desde la perspectiva y los problemas del territorio, indagando puentes de encuentro entre ambos tipos de aproximaciones. A tal fin, hace un recorrido por el estado de la cuestión y el tratamiento normativo que merece el territorio desde tales perspectivas y concluye con una propuesta metodológica sustentada en los planteamientos del desarrollo territorial integrado.Applying the concept of sustainability to agriculture entails the recognition that, apart from the production function, it has other roles (environmental, social, cultural closely linked to its territorial substratum that are in ever greater demand. This is expressly embraced by the notion of agricultural multifunctionality and is understood as such from other conceptual and regulatory frameworks which had hitherto had no connection with the sector, but which are showing more and more interest in agricultural areas as territorial structures, repositaries of cultural heritage- and landscape-related resources. Notwithstanding, the way that they understand territory is quite different, their analytical scales extremely disparate

  14. LA MANCHA EN EL QUIJOTE: TERRITORIO Y LITERATURA PARA UNA GEOGRAFÍA DIDÁCTICA

    Directory of Open Access Journals (Sweden)

    Lorenzo Sánchez López

    2005-12-01

    Full Text Available RESUMEN:Todas las acciones humanas se realizan en el tiempo y en el espacio con técnicas materiales o inmateriales que territorializan. La acción humana es técnica, territorial y temporal, y siempre consecuencia de la intención y la capacidad de acción. Realizada en el "lugar" que la posibilita, su desarrollo escalar depende de su intensidad y de la situación relacional del centro de la acción. Así, las intenciones pueden ser locales y sin embargo globales, dado que pueden afectar a todos los lugares en razón directa a la intensidad y a la situación relacional de los territorios con aquel "lugar" donde se genera el acontecimiento y en razón inversa a la distancia.. En el caso que proponemos , el "lugar", es La Mancha, territorio local y temporal de la percepción. La intención es la Justicia. La acción es universal, intemporal y didáctica..PALABRAS-CLAVE:Territorio, literatura, intención, acción, local, global.ABSTRACT:Al1 human actions are carried out intime or space with material or imrnaterial techniques which they territorialize. Human action is technical, territorial and temporal and is always a consequence of the intention and capacity of the action. Carried out in the "place" which makes it posible, its development increases depending upon its intensity and the relational situation of the centre of the actionKEY WORDS: Territory, literature, intention, action, global, localRÉSUMÉ: Toutes les actions humaines se realisent dans le temps e dants l-espace avec des techniques matérielles e inmatérielles qui font le temtoire, L-actión humaine est, technique, temtoriale et temporelle e toujours, conséquence de 1' intention et de la capacité d'actión. Réalisée dans "lieu" qui la rend possible, son développement scalaire depend de son intensité et de la situation de relactión du centre de 1' actión.MOTS CLÉ: Territoire, literatura, intentión, actión, global, local.

  15. Il GEOatleta moderno

    Directory of Open Access Journals (Sweden)

    Francesco Bartoli

    2006-12-01

    Full Text Available Nell'ultimo decennio gli straordinari sforzi tecnologici hanno evoluto il settore geomatico e portato enormi vantaggi nell'ambito dei cosiddetti servizi a valore aggiunto. Tuttavia la svalutazione commerciale del sistema di navigazione satellitare ha fatto del navigatore un oggetto di uso comune, quasi alla pari del più quotato telefono cellulare. Scemata la corsa al cellulare più modaiolo è subentrata quella al navigatore satellitare più tecnologico con cartografia e punti di interesse più aggiornati. E' assai frequente trovare commercializzazioni degli operatori di telefonia che unisconoal dispositivo mobile il sistema di navigazione, grazie anche apolitiche di businness agreement tra le varie major. L'utilizzo dei dispositivi GPS è davvero ancora arenato alla semplice ricerca di un percorso o di un indirizzo da raggiungere? L'usodi tali apparecchiature può inserirsi all'interno di target quali l'intrattenimento e le attività ricreative? Negli ultimi anni stiamo riscoprendo la bellezza della natura e il piacere di dedicarci ad una serie di attività sportive outdoor che ci conciliano con essa, unendo ai benefici della mente quelli del corpo derivanti da una corretta sollecitazione della propria frequenza cardiaca. Questa mia relazione vuole essere un diario di viaggio nelle quotidiane attività all'aria aperta di un atleta non professionista, praticate durante le quattro stagioni sfruttando le tecnologie legate alla triangolazione satellitare.

  16. Rehabilitación de la Patagonia. Un territorio periférico escrito por la narrativa argentina actual

    Directory of Open Access Journals (Sweden)

    Alejandro Gasel

    2011-06-01

    Full Text Available La comunicación consiste en la exposición de las formas de la inscripción de la Patagonia Austral en la contemporaneidad de la narrativa argentina. Puntualmente pensando dos novelas: Falsa Calma de Sonia Cristoff (2004 y La Siberia de Cristina Siscar (2006 trataremos de razonar qué sigue de vigente y qué aparece como una rehabilitación de este territorio en el proceso de producción narrativa. En este sentido, pensamos que podemos plantear no solamente el fenómeno de la representación actual de este territorio sino la productividad reconocida en los textos a partir de un juego intertextual, que sincretiza a una memoria precedente que ha descripto y inscripto el territorio con la necesidad de referencia la crisis del presente o actualidad del territorio en formas de umbralidad. Para dar cuenta de este proceso hemos de remitirnos a pensar la enunciación de los textos, los usos de géneros discursivos, en especial, el relato viaje y la implicancia de la historia y la memoria para referirse políticamente a la Patagonia Austral argentina que sigue siendo tematizado en el variopinto paisaje de la Literatura Argentina.

  17. Rehabilitación de la Patagonia. Un territorio periférico escrito por la narrativa argentina actual

    Directory of Open Access Journals (Sweden)

    Alejandro Gasel

    2011-07-01

    Full Text Available http://dx.doi.org/10.5007/1984-784X.2011v11n16p50 La comunicación consiste en la exposición de las formas de la inscripción de la Patagonia Austral en la contemporaneidad de la narrativa argentina. Puntualmente pensando dos novelas: Falsa Calma de Sonia Cristoff (2004 y La Siberia de Cristina Siscar (2006  trataremos de razonar qué  sigue de vigente y qué aparece como una rehabilitación  de este territorio en el proceso de producción narrativa. En este sentido, pensamos que podemos plantear  no solamente el fenómeno de la representación actual de este territorio sino la productividad reconocida en los textos a partir de un juego intertextual, que sincretiza a una memoria precedente que ha descripto y inscripto el territorio con la necesidad de referencia la crisis del presente o actualidad del territorio en formas de umbralidad. Para dar cuenta de este proceso  hemos de remitirnos a pensar la enunciación  de los textos, los usos de géneros discursivos, en especial, el relato viaje y la implicancia de la historia y la memoria para referirse políticamente a la Patagonia Austral argentina que sigue siendo tematizado en el variopinto paisaje de la Literatura Argentina.

  18. Agua, territorio y gestión: caminos por recorrer / Water, territory and management: the road ahead

    Directory of Open Access Journals (Sweden)

    Oscar Buitrago Bermúdez

    2011-09-01

    como imprescindible, para asegurar el acceso de todas las formas de vida al agua, la formación de comunidades y sociedades reflexivas y autónomas capaces de gobernar sus vidas y sus territorios, para lo cual, la educación crítica se estima como una estrategia primordial.

  19. Il dono del racconto

    DEFF Research Database (Denmark)

    Polito, Paola

    1998-01-01

    /racconto in prima persona d'una storia di formazione/. Dopo aver individuato, sulla base di considerazioni d'ordine tematico e quantitativo, la prevalenza di tale genere romanzesco (se pure intrecciato ad altri), se ne ricostruiscono le tracce in vari ambiti d'analisi, rilevando in particolare l......: la sua parola segue il percorso esistenziale di cui ci dà testimonianza, l'ostinata ma anche fatale formazione di sé come portavoce epico di un popolo muto e diseredato. La progressiva costituzione del senso della propria vicenda, attraverso una quête che spazia in diversi ambiti, oltre ad essere...

  20. Il muro nella mente:

    Directory of Open Access Journals (Sweden)

    Carmen Concilio

    2013-07-01

    Full Text Available A 78 anni, Nadine Gordimer, premio Nobel per la letteratura nel 1991, è infaticabile: il suo ultimo romanzo The Pick up è stato pubblicato negli Stati Uniti e in Inghilterra, dove ha ricevuto però tiepida accoglienza,e ora anche in Italia1. Alcuni mesi fa, tuttavia, Nadine Gordimer veniva ricordata dai giornali per un’impresa non letteraria: si tratta di un film-documentario dal titolo Johannesburg-Berlin, The Wall in the Mind, che Gordimer ha scritto e che ha girato con suo figlio, Hugo Cassirer, nel 1995-1996.

  1. Il Maestro della Commenda di Meldola e la magione ospitaliera di San Giovanni Battista

    Directory of Open Access Journals (Sweden)

    Paolo Cova

    2012-02-01

    Full Text Available L’intervento propone, attraverso l’indagine di alcuni dipinti di area forlivese, una prima ricostruzione della personalità di un interessante interprete locale del XV secolo, provvisoriamente denominato Maestro della Commenda di Meldola. Lo studio, parte integrante della mia tesi di dottorato, prende le mosse dall’analisi dell’affresco dell’Oratorio di San Giovanni Battista a Meldola, per poi allargarsi ad altre emergenze del territorio circostante, fino ai lacerti pittorici emersi nella chiesa della Santissima Trinità di Forlì. Nella prima parte dell’articolo viene ricostruita la storia dell’Oratorio di San Giovanni Battista presso Villa Fronticelli a Meldola: già magione templare di Santa Maria Biacque, nel 1312, in seguito al processo ai templari, passò alle dipendenze della precettoria dei cavalieri gerosolimitani di San Giovanni di Palareto. La realizzazione dell’affresco deve essere probabilmente inserita all’interno dei lavori di ristrutturazione intrapresi dai giovanniti dopo la metà del XV secolo. Nella seconda parte dell’articolo invece si procede alle indagini tecniche e stilistiche relative alla pittura murale che rappresenta la Madonna col Bambino e San Giovanni Battista. L’affresco mutilo è opera di un interessante maestro che agisce nella sfera del tardogotico locale, mostrando però tenui accenti rinascimentali caratteristici alla pittura forlivese tra sesto e settimo decennio del Quattrocento. Muovendo dalle ricerche di Anna Tambini e Giordani Viroli, attraverso l’analisi di diverse testimonianze del territorio, viene così proposta la ricostruzione di un corpus pittorico caratterizzato da stringenti affinità stilistiche, che, confermando l’appartenenza del suo anonimo pittore ad un milieu stilistico caro ad altri interpreti forlivesi del periodo, come il Maestro di Castrocaro o il Maestro di San Pier Damiani, aiuta ulteriormente a chiarire il panorama artistico romagnolo all’avvento della

  2. Il bilinguismo disegnato

    Directory of Open Access Journals (Sweden)

    Graziella Favaro

    2013-07-01

    Full Text Available Il tema della diversità linguistica e del riconoscimento e della valorizzazione delle forme di bilinguismo dei bambini e dei ragazzi è cruciale nella scuola multiculturale e plurilingue. Ma quale rappresentazione della “mente bilingue” hanno i parlanti una o più lingue? Come immaginano la testa di chi e bilingue e dove collocano le diverse parole? Abbiamo chiesto agli alunni, piccoli e grandi, di alcune scuole di “disegnare il bilinguismo”: emergono in maniera vivida i “posti” diversi in cui le lingue si installano, i dubbi e le spiegazioni dei bambini, la necessità del controllo e la coloritura affettiva dell’uno e dell’altro idioma.  Drawing bilingualism The theme of linguistic diversity and the recognition and appreciation of forms of bilingualism in children and young people is crucial in a multilingual, multicultural school environment. But how do speakers of one or more languages imagine a “bilingual mind”? How do they imagine a bilingual person’s head and where are the different words located? We asked school children to “draw bilingualism”. The “placement” of the different languages, the children’s doubts and explanations and their need to check and the affective coloring of one and the other language emerged.

  3. Desarrollo y territorio: clusters tecnológicos en la periferia

    Directory of Open Access Journals (Sweden)

    Graciela Gutman

    2016-01-01

    Full Text Available La difusión de nuevos paradigmas tecnológicos plantea interrogantes sobre sus desafíos para promover el desarrollo y la diversificación productiva en países y territorios de la periferia. Sectores y regiones que eran centrales bajo paradigmas tecnológicos previos pierden relevancia relativa, y surgen otros espacios como lugares privilegiados de acumulación del capital. Nuevos actores, formas de articulación y de governance redireccionan los flujos de conocimientos, financieros y de bienes, así como los mecanismos de apropiación de ganancias y rentas. Este artículo pone el acento en los impactos locales /regionales de la difusión de los nuevos paradigmas tecnológicos, en particular, con la conformación de clusters de TICs y de Biotecnología, examinando experiencias de este tipo en Argentina

  4. PATRIMONIO INMATERIAL, RECURSO TURÍSTICO Y ESPÍRITU DE LOS TERRITORIOS

    Directory of Open Access Journals (Sweden)

    Ana Olivera

    2011-01-01

    Full Text Available El patrimonio cultural intangible es un elemento del territorio que aún no ha sido suficientemente tratado por la Geografía Social y Cultural. No sólo es un recurso turístico, sino también un factor fundamental de identidad, y sociabilidad. Su gran vulnerabilidad hace necesarias urgentes medidas de protección para preservar la diversidad cultural en un mundo globalizado. Con este fin la UNESCO ha proclamado Patrimonio de la Humanidad varios bienes intangibles. Relacionados con ese patrimonio han surgido nuevos turismos, además del tradicional turismo étnico, como el esotérico y el New Age.

  5. Turismo y Patrimonio cultural inmaterial: Alternativa de complementariedad para el desarrollo de los territorios rurales

    Directory of Open Access Journals (Sweden)

    Alonso Rodríguez-Chaves

    2016-11-01

    Full Text Available El nuevo concepto de desarrollo rural generado en las últimas décadas, ha ayudado a redefinir la funcionalidad de los territorios rurales. Esta reconceptualización ha evolucionado en estrecha relación y complementariedad, entre los habitantes y los recursos disponibles en dicho entorno. En ese entramado, el trabajo devela al lector la importancia de la diversificación económica y la consecuente inserción de actividades potencialmente beneficiosa en la vida y quehacer rural. En principio, destaca el aprovechamiento del patrimonio cultural inmaterial como estrategia, para mejorar la competitividad de la actividad turística y, a la vez, para fortalecer las identidades y los rasgos culturales de los colectivos rurales.

  6. Reflexiones sobre territorio e imagen ibéricos: el área alicantina

    Directory of Open Access Journals (Sweden)

    Trinidad TORTOSA ROCAMORA

    2009-11-01

    Full Text Available RESUMEN: Dentro de los análisis de las formas directas de intervención territorial en la Península Ibérica T. Tortosa y J.A. Santos proponen la posibilidad de elaborar hipótesis sobre la definición de territorios a través del análisis iconográficos y de la distribución de diversas manifestaciones materiales del mundo ibérico, en este caso del área alicantina. ABSTRACT: As far as the forms of ancient interventions on the Iberian Peninsula is concerned, T. Tortosa and J.A. Santos propose —as a hypothesi— the use of iconographic analysis and distribution patterns of cultural manifestations, particularly in the iberian area of Alicante and Murcia.

  7. Estructura agraria: lógicas disimiles en la concepción del territorio

    Directory of Open Access Journals (Sweden)

    Wilson González Santos

    2016-06-01

    Full Text Available El desarrollo como estrategia que mitiga el conflicto es la apuesta dominante en los procesos de intervención en el espacio rural. No obstante, esta situación ignora que la estructura agraria como fenómeno que evidencia la cuestión agraria se ha construido con el permanente pulso entre conflicto y desarrollo. El documento hace parte del referente conceptual para analizar las categorías conflicto y desarrollo en el territorio campesino. Se propone la trialectica espacial como alternativa para la comprensión del campesinado y sus lógicas disimiles a las contenidas en sus procesos de intervención rural.

  8. Tratado de Libre Comercio de América del Norte, territorio financiero del libre comercio

    Directory of Open Access Journals (Sweden)

    Margarita Camarena Luhrs

    2014-09-01

    Full Text Available A veinte años de la firma del Tratado de Libre Comercio de Norteamérica, posiblemente ha agotado sus posibilidades. De sus objetivos, los que resultaron viables, fue la constitución de un territorio financiero de libre comercio, libre y continuo en Norteamérica. Con este proceso destaca el imperativo financiero de la expansión comercial trilateral; pero también, tal como se muestra con esta reflexión, que tras esos resultados comerciales opera una inteligencia financiera y territorial, realmente geoestratégica, promotora de extrema “liberalización proteccionista” que traspasa y supera las capacidades nacionales de Estados.

  9. L’uso di piattaforme digitali collaborative nella prospettiva di un’amministrazione condivisa. Il progetto Miramap a Torino

    Directory of Open Access Journals (Sweden)

    Cristina Coscia

    2016-06-01

    Full Text Available Lo scritto intende illustrare un approccio innovativo alla pianificazione urbana e all’Amministrazione condivisa basato sull’uso di piattaforme digitali collaborative PA/cittadino. Tale prospettiva è declinata nel progetto pilota MiraMap, a Torino, nella Circoscrizione Mirafiori Sud, di cui è responsabile un gruppo di ricerca del Politecnico di Torino. Il progetto implementa e sviluppa una precedente esperienza effettuata nel 2013 (Crowdmapping MirafioriSud, il cui scopo principale era quello di verificare se l'uso delle ICT potesse generare e supportare processi di inclusione sociale. Attraverso la lettura del processo MiraMap, degli obiettivi, della metodologia adottata, delle fasi e delle linee di azione vengono evidenziati ragionamenti di natura interdisciplinare e tecnica relativi a: la strutturazione dei rapporti con le Istituzioni, in particolare la Pubblica Amministrazione, nei processi di pianificazione e gestione dello spazio pubblico; l’innesco di processi di inclusione, partecipazione e di civic engagement; l’identificazione degli apporti che tali sperimentazioni possono generare nella costruzione di una rinnovata governance urbana. Il presente contributo delinea infine una possibile metodologia per il monitoraggio e la valutazione di impatto ex post, basata sulla Community Impact Analysis/Evaluation (CIA/CIE, che valuta in modo descrittivo gli impatti – pecuniari e non – originati dal progetto, in rapporto ai diversi soggetti coinvolti. L’impiego delle ICT può favorire processi di trasparenza e rafforzare l’accountability della PA, a condizione che la tecnologia sia fattore abilitante e non di esclusione. L’analisi puntuale del caso fornisce spunti di riflessione in merito a tale approccio innovativo: la relazione cittadino/PA può contribuire nel medio-lungo termine a veicolare impatti socio-economici positivi sul territorio, rendere il cittadino più informato e coinvolto e l’Amministrazione pi

  10. Política ambiental y territorios indígenas de Sonora

    Directory of Open Access Journals (Sweden)

    Diana Luque

    2012-01-01

    Full Text Available La política ambiental en México ya es parte de la agenda de seguridad nacional, sin embargo, uno de sus instrumentos de planeación clave es el OET (Ordenamiento Ecológico del Territorio, el cual no ha logrado el impacto previsto. Se propone a los pueblos y territorios indígenas de Sonora como sector estratégico para la implementación de los OET, para lo cual se considera necesario profundizar en su problemática actual. Por ello, se realiza un análisis socioambiental de los complejos bioculturales de Sonora, a partir del marco de reflexión de la ecología política y la perspectiva biocultural. Esto se logra a partir de un análisis interdisciplinario donde se conjugan epistemologías y metodologías de los campos de las ciencias sociales y de la ecología. El análisis socioambiental se organiza a partir de dos grandes temas: la territorialidad y la comunidad indígena contemporánea. Se concluye que el formato actual de los OET es poco operativo, por lo que se dan recomendaciones para eficientar su implementación. Por último, se resalta la importancia de la atención de los complejos bioculturales, en primera instancia como un tema de justicia ambiental, así como por su capacidad para incidir a favor de los temas globales ambientales, como el cambio climático y la disponibilidad y calidad del agua.

  11. Territorio, urbanismo y crisis. Una mirada al Medio Vinalopó (Alicante

    Directory of Open Access Journals (Sweden)

    Xavier Amat Montesinos

    2009-01-01

    Full Text Available Las claves de la planificación territorial en la Comunidad Valenciana han estado en el protagonismo de la iniciativa municipal y la ausencia de directrices en la escala supralocal. Además, los instrumentos normativos han favorecido la desregulación del suelo y la entrada del capital inmobiliario, con lo que el territorio se ha convertido en el soporte de valor del que administraciones públicas y entidades privadas han obtenido beneficios inmediatos. Multitud de planes y proyectos se han enunciado e iniciado en la región valenciana durante los últimos 15 años, promocionando un modelo de crecimiento que ha alimentado la situación actual de recesión y crisis. La alta indiferencia territorial de estos planes y proyectos, ha provocado la transformación de todo tipo de espacios: litorales, de interior e incluso pueblos de montaña. En el presente documento, se analizan las causas y consecuencias de este fenómeno en lacomarca interior alicantina del Medio Vinalopó. Como principales aportaciones, se identifican y caracterizan las actuaciones iniciadas y previstas sobre el territorio desde un punto de vista conjunto de los 11 municipios del área de estudio. Posteriormente, se ofrece un análisis prospectivo del modelo territorial comarcal. Finalmente, se consideran las implicaciones ambientales, económicas y sociales de este modelo de crecimiento que ha conducido a una situación de crisis, tratando de buscar soluciones y oportunidades desde la planificación territorial.

  12. Il MUDE Piemonte - modello unico digitale per l’edilizia: un progetto organizzativo

    Directory of Open Access Journals (Sweden)

    Livio Mandrile

    2012-12-01

    Full Text Available Le tecnologie dell’informazione e della comunicazione consentono di affrontare la reingegnerizzazione dei processi amministrativi attraverso servizi informatici definiti “di cooperazione applicativa”, aprendo nuove prospettive per semplificare il rapporto fra cittadino e Pubbliche Amministrazioni e agevolare lo scambio di documenti e informazioni. Il MUDE Piemonte – modello unico digitale per l’edilizia - è un sistema informativo realizzato attraverso la collaborazione di tutti i livelli di governo del territorio regionale, che crea un archivio digitale delle pratiche edilizie presentate allo Sportello per l’Edilizia, utilizzando il mezzo telematico per l’interazione fra professionista e Pubblica Amministrazione e l’interscambio informativo fra le banche dati amministrative. Il MUDE Piemonte è un sistema che realizza un ambiente operativo di fruizione / aggiornamento della base di dati territoriali ed amministrativi ad uso di più soggetti ed enti e in costante evoluzione in ragione dell’apporto progettuale offerto da tutti gli attori coinvolti nei procedimenti autorizzativi edilizi.

  13. Abitare il paradosso

    Directory of Open Access Journals (Sweden)

    Daniele Capra

    2011-10-01

    Full Text Available L'articolo intende presentare spunti per una rilettura delle tesi esposte da Donald Woods Winnicott secondo una prospettiva filosofica di stampo pragmatico-ermeneutico, con particolare riferimento al tema della istituzione e costituzione della relazione oggettuale, nell’intento di ricercare, rendendolo evidente, il lgouo dvoe un oegtgto copmlesso cmoe qeutsa fsrae asusme un singifiacto e la fliosoifa, sloo in un mdoo più avevrtito riseptto alle sicezne, è psosiblie. To inhabit the paradox The article aims to present ideas for a new reading of theses expounded by Donald Woods Winnicott, according to a philosophical perspective of pragmatic-hermeneutic kind, with special reference to the establishment and constitution of the object relationship, in order to search, making it clear, the palce wehre an ojbect as copmelx as tihs prahse tkeas on a maeinng and piholposhy, olny in a way mroe exerpineced tahn secinecs, is psoislbe.

  14. Il GEOatleta moderno

    Directory of Open Access Journals (Sweden)

    Francesco Bartoli

    2006-12-01

    di tali apparecchiature può inserirsi all'interno di target quali l'intrattenimento e le attività ricreative? Negli ultimi anni stiamo riscoprendo la bellezza della natura e il piacere di dedicarci ad una serie di attività sportive outdoor che ci conciliano con essa, unendo ai benefici della mente quelli del corpo derivanti da una corretta sollecitazione della propria frequenza cardiaca. Questa mia relazione vuole essere un diario di viaggio nelle quotidiane attività all'aria aperta di un atleta non professionista, praticate durante le quattro stagioni sfruttando le tecnologie legate alla triangolazione satellitare.

  15. El ordenamiento territorial a partir de la producción social del territorio. Caso de estudio: Parque de la 93.

    OpenAIRE

    Aulestia Obregón, Juan Felipe

    2014-01-01

    El territorio, como una representación de la sociedad, manifiesta relaciones poder y situaciones de confrontación entre las clases sociales que lo habitan, consolidando escenarios funcionales a éstas. A continuación se analiza la forma en la que incide la producción social del territorio en el ordenamiento territorial, en el caso de la transformación del Parque de la 93. La ordenación del territorio no surge de manera espontánea, sino que responde a unos intereses por localizar espacios de pr...

  16. Interleukin-18 and IL-18 Binding Protein

    NARCIS (Netherlands)

    Dinarello, C.A.; Novick, D.; Kim, S.; Kaplanski, G.

    2013-01-01

    Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1beta, IL-18 is synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine but unlike IL-1beta, the IL-18 precursor is constitutively present in nearly all cells in healthy humans

  17. Il congiuntivo nel Goldoni

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    1970-11-01

    Full Text Available Nelle sue commeclie dialettali, Goldoni spesso ricorre al congiuntivo. La forma e tanto frequente e tanta è la coerenza nell'uso che ci testimonia della popolarita del congiuntivo nel veneziano parlato del suo tempo. E ancora non sapremmo elencarne tutte le forme, giacche, nel presente almeno, una speciale per il congiuntivo esiste quasi solo per la 3.a persona (come nell'indicativo, anche nel congiuntivo coincidono la 3.a del sg. e la 3.a del pl.. Pochi sono i verbi che mostrano una forma a parte per il congiuntivo nella La pers. sg. Citiamo dalla Casa nova: »fe conto che sia morto per vu«, I, 6; »E no le vol ehe maledissa sta casa e che diga roba de quel strambo de so fradelo«, II, 5; »se no volè che vaga, lasserò star«, II, 6; »bisognerà che dipenda da ela«, I, 6; »ghe son, bisogna che ghe staga, I, 2; »Bisognerà che m'inzegna da qualche altra banda«, I, 15. Quasi inesistente la 2.a pers. sg.; >>Siestu benedeta, dove che tu xe«, Rusteghi, II, 3. La scarsità della forma nel congiuntivo è da riconnettere alla scarsità della 2.a pers. in generale nelle commedie. Non ci sono forme del congiuntivo nel plurale: »avanti che lo spartimo, fevelo mostrare«, Baruffe, I, 5; »acciò che vegni a discreditar la mia casa«, Rusteghi, II, 3; »son vegnua a posta, acciò che parlè”, Rusteghi, III, 2.

  18. Il bizzarro mondo dei quanti

    CERN Document Server

    Camejo, Silvia Arroyo

    2008-01-01

    Scritto prima dell'esame di maturità da una giovane di eccezionale talento, questo libro colma il vuoto esistente tra la letteratura divulgativa sulla fisica quantistica, che normalmente evita ogni formula matematica, e la letteratura specialistica, ben farcita, invece, di matematica avanzata. L'autrice, appena diciannovenne, con l'ausilio della sola matematica della scuola superiore, introduce il lettore ai principi della fisica dei quanti. Se ne ricava uno sguardo profondo sul microcosmo, il regno affascinante delle particelle elementari: oggetti il cui comportamento si distingue in modo drastico e fondamentale da tutto ciò a cui è avvezzo il nostro umano buonsenso. "Un libro... che avrei desiderato avere a 17 anni". Silvia Arroyo Camejo "In modo assolutamente preciso dal punto di vista fisico, l'autrice spiega con grande passione e divertimento i fondamenti della moderna fisica quantistica ... " Prof. Reinhold A. Bertlmann "Un libro stupefacente di un'autrice straordinaria! Si avverte il suo entusiasmo ...

  19. La correlazione di immagini per la generazione di modelli 3D per il patrimonio costruito

    Directory of Open Access Journals (Sweden)

    Filiberto Chiabrando

    2013-06-01

    Full Text Available I modelli dettagliati 3D derivati dalle tecniche di rilievo metrico digitale vengono impiegati con crescente sviluppo in moltissimi campi applicativi, dal rilievo del territorio e delle aree urbane, per i quali sono stati testati e messi a punto processi di elaborazione di dati satellitari o aerei, ai beni paesaggistici strettamente correlati al territorio fino alla sfera dei Beni Culturali. L’elevato dettaglio ottenibile delle superfici e la loro accuratezza li rende particolarmente stimati per un largo insieme di finalizzazioni. Questo contributo esamina in particolare i cosiddetti sensori passivi e i relativi sistemi di correlazione d’immagine, poiché l’efficacia dei modelli ottenibili, il basso costo e la ricchezza d’informazione offerta, rendono questi modelli di importanza strategica nei settori caratterizzati da scarse risorse come quello dei Beni Culturali. Dopo una breve rassegna dei metodi disponibili, è riportato un esame dell’applicazione degli algoritmi di base implementati in due diffusi software; a corredo alcune valutazioni circa le strategie di matching in riferimento alle geometrie di acquisizione, alle tipologie di materiali e finiture superficiali degli oggetti rilevati. Una sezione sperimentale finale descrive alcuni test ed una loro lettura critica per la comparazione di differenti soluzioni da riferire a diversi casi studio.

  20. La materia e il cielo

    Directory of Open Access Journals (Sweden)

    Paolo Zermani

    2012-06-01

    Full Text Available Il testo che l’architetto Paolo Zermani propone per questo convegno si articola in tre parti. La prima è premessa ai due esempi proposti dalla propria vasta attività di progettista. Si tratta di mettere a sbalzo la liminalità dello spazio sacro, ossia il suo costruirsi al limite tra terra e cielo, confine materiale di più ampia significanza simbolica, tra fisica e metafisica, tra elementi evocativi, comunque materiali, e il “cielo dei cieli” di cui parla Agostino.  Intersezione di queste valenze è ancora il tipo architettonico, nella sintesi tra oriente ed occidente offerta dalla cultura romana e dalla forma della croce.Il significato del paesaggio nella composizione dell’architettura è esemplificato nella descrizione di due progetti: il Cimitero di Sansepolcro e il Nuovo Tempio per la Cremazione di Parma, il primo innestato nel Paesaggio Collinare di Piero della Francesca, il secondo incastonato nelle maglie della Limitatio Romana della pianura padana in prossimità di Valera, recinto sacro e nuovo altare della città di Parma. (abstract a cura di Luigi Bartolomei

  1. Los actores sociales y el territorio: elementos a tener en cuenta en un plan de ordenamiento territorial

    Directory of Open Access Journals (Sweden)

    Enrique Hugo Fabregat

    2015-04-01

    Full Text Available El objetivo de este trabajo es explicar como los actores sociales y la sociedadintervienen en un determinado territorio, en este caso el Valle Inferior del RíoNegro, a partir de transformar y organizar al mismo a través de cambios tanto desde lo temporal como desde lo espacial e identificar a los mismos como elementos a tener en cuenta en un proceso de ordenamiento territorial.El territorio es una construcción social, por lo tanto intervienen en él, diferentes actores que actúan en distintas escalas y hacen que el escenario adquiera mayor o menor complejidad en forma permanente, de acuerdo a las acciones que estos actores realizan.En el caso del Valle Inferior del Río Negro, estos actores sociales, vienenconstruyendo este territorio desde hace mucho tiempo. Es posible hacer unseguimiento de sus trayectorias de construcción del territorio, desde lapresencia de los pueblos originarios en la zona hasta nuestros días.Las acciones que cada uno de los grupos de actores sociales hicieron sobreeste territorio dejaron marcas, que hasta el día de hoy es posible observar,como por ejemplo los cementerios de pueblos Tehuelches, localizados en lallanura del valle del río.Hay que destacar que todos estos procesos, sirven además para poder pensar, discutir y elaborar Políticas Públicas que colaboren en un Plan deOrdenamiento Territorial para el Valle Inferior del Río Negro.En cuanto a los aspectos metodológicos, el trabajo se realizo a partir delanálisis del territorio y la identificación en el mismo de las diferentes unidadesde paisaje, las que surgen del proceso de construcción social. Para ello se tuvo en cuenta en primer lugar las características más relevantes y significativas de cada sector y, en segundo lugar se describió la parte visible del espacio que es el paisaje actual del valle.

  2. IL-5 and IL-5 receptor in asthma

    Directory of Open Access Journals (Sweden)

    ATC Kotsimbos

    1997-12-01

    Full Text Available Eosinophils, along with mast cells are key cells involved in the innate immune response against parasitic infection whereas the adaptive immune response is largely dependent on lymphocytes. In chronic parasitic disease and in chronic allergic disease, IL-5 is predominantly a T cell derived cytokine which is particularly important for the terminal differentiation, activation and survival of committed eosinophil precursors. The human IL-5 gene is located on chromosome 5 in a gene cluster that contains the evolutionary related IL-4 family of cytokine genes. The human IL-5 receptor complex is a heterodimer consisting of a unique a subunit (predominantly expressed on eosinophils and a beta subunit which is shared between the receptors for IL-3 & GM-CSF (more widely expressed. The a subunit is required for ligand-specific binding whereas association with the beta subunit results in increased binding affinity. The alternative splicing of the alphaIL-5R gene which contains 14 exons can yield several alphaIL-5R isoforms including a membrane-anchored isoform (alphaIL-5Rm and a soluble isoform (alphaIL-5Rs. Cytokines such as IL-5 produce specific and non-specific cellular responses through specific cell membrane receptor mediated activation of intracellular signal transduction pathways which, to a large part, regulate gene expression. The major intracellular signal transduction mechanism is activation of non-receptor associated tyrosine kinases including JAK and MAP kinases which can then transduce signals via a novel family of transcriptional factors named signal transducers and activators of transcription (STATS. JAK2, STAT1 and STAT 5 appear to be particularly important in IL-5 mediated eosinophil responses. Asthma is characterized by episodic airways obstruction, increased bronchial responsiveness, and airway inflammation. Several studies have shown an association between the number of activated T cells and eosinophils in the airways and abnormalities

  3. Nuove Tecnologie per il Monitoraggio e la Gestione dei giardini storici

    Directory of Open Access Journals (Sweden)

    Maurizio Romani

    2012-07-01

    Full Text Available ItSotto la spinta dei cambiamenti socio-economici e di significativi progressi tecnici, la gestione dei giardini storici e degli spazi verdi in genere, sta vivendo un periodo di forte cambiamento ed evoluzione. Nel tentativo di razionalizzare l’uso delle risorse naturali e umane, nascono nuovi servizi che fanno intravedere la necessità di creare specifiche figure professionali, in grado di colmare in tempi rapidi il divario tra le potenzialità applicative offerte dalle nuove tecnologie e le diverse realtà operative, ancora legate all’uso di pratiche e metodologie tradizionali. Anche nel settore dei giardini e dei parchi storici è giunto il momento di approfondire i temi relativi alla loro conservazione e valorizzazione, che oggi sono strettamente legati a una concreta sostenibilità economica e ambientale delle pratiche di gestione e di promozione. Queste considerazioni sono state alla base di una serie di iniziative e di progetti promossi a livello nazionale ed europeo, che, grazie all’integrazione di strumenti ICT, SMART-Sensors e IA, in alcuni casi si sono concretizzati nella realizzazione di metodologie e soluzioni di grande interesse operativo.Le procedure e i criteri presentati in questo articolo sono il risultato dell’attività di ricerca e trasferimento tecnologico condotta dal CNR-IBIMET di Firenze negli ultimi dieci anni. Già nella sua versione prototipale, il sistema proposto mostra tutte le sue potenzialità di monitoraggio e supporto alle attività gestionali e manutentive degli spazi verdi, aprendo la strada a una progressiva automazione e virtualizzazione delle procedure (creazione di scenari, elementi essenziali per la successiva valorizzazione e promozione del bene a livello sociale e culturale.In particolare, oltre allo schema logico del sistema, si discutono alcune tra le funzioni di monitoraggio di maggiore interesse (disponibilità idrica, stato fitosanitario e fenologia, evidenziando quali siano i vantaggi

  4. IL-1b, IL-6 and IL-8 Levels in Gyneco-Obstetric Infections

    Directory of Open Access Journals (Sweden)

    Beatriz Basso

    2005-01-01

    Full Text Available Objective. During pregnancy cytokines and inflammatory mediators stimulate the expression of prostaglandin, the levels of which determine the onset of labor. The aim of this work was to study interleukin IL-1β, IL-6 and IL-8 levels in the vaginal discharge, serum and urine of pregnant women with genitourinary infection before and after specific treatment. One hundred and fifty-one patients were studied during the second or third trimester of their pregnancy.

  5. Più turismo con il GIS

    Directory of Open Access Journals (Sweden)

    Erminio Paolo Canavese

    2015-02-01

    Full Text Available In questa case history Virtualgeo presenta la sua soluzione per diffondere l’uso delle nuove tecnologie geomatiche a supporto del turismo grazie a un WebGIS ricco di funzionalità. La realizzazione di un percorso turistico digitale auspica di fornire possibili suggerimenti all’interno del processo di adeguamento tecnologico perseguito dalle municipalità. In this case study Virtualgeo presents its solution to spread the use of new geomatics technologies to support tourism through a webGIS that is rich of features. The creation of a tourist route through digital technology-based processing tools hopes to provide possible suggestions in the process of technological updating pursued by the municipalities of Eastern Venice, providing those simple solutions that become more and more "necessary" in an era constructed through the network. The created webGIS is a tourist product that is useful for the institutions directly concerned with the promotion of the territory; for the "natives", i.e. the citizens who often know little the area where they live, and for the eco-tourists visiting this wonderful land. The webGIS should not be neglected as an extraordinary tool of knowledge of the area (cultural heritage, landscape, environment for teaching in schools of all levels.

  6. Più turismo con il GIS

    Directory of Open Access Journals (Sweden)

    Erminio Paolo Canavese

    2015-02-01

    Full Text Available In questa case history Virtualgeo presenta la sua soluzione per diffondere l’uso delle nuove tecnologie geomatiche a supporto del turismo grazie a un WebGIS ricco di funzionalità. La realizzazione di un percorso turistico digitale auspica di fornire possibili suggerimenti all’interno del processo di adeguamento tecnologico perseguito dalle municipalità.In this case study Virtualgeo presents its solution to spread the use of new geomatics technologies to support tourism through a webGIS that is rich of features. The creation of a tourist route through digital technology-based processing tools hopes to provide possible suggestions in the process of technological updating pursued by the municipalities of Eastern Venice, providing those simple solutions that become more and more "necessary" in an era constructed through the network. The created webGIS is a tourist product that is useful for the institutions directly concerned with the promotion of the territory; for the "natives", i.e. the citizens who often know little the area where they live, and for the eco-tourists visiting this wonderful land. The webGIS should not be neglected as an extraordinary tool of knowledge of the area (cultural heritage, landscape, environment for teaching in schools of all levels.

  7. IL-1β suppresses innate IL-25 and IL-33 production and maintains helminth chronicity.

    Directory of Open Access Journals (Sweden)

    Mario M Zaiss

    Full Text Available Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution between helminths and their mammalian hosts; however, the molecular mechanisms by which these organisms avert immune rejection are not clear. We have found that the natural murine helminth, Heligmosomoides polygyrus bakeri (Hp elicits the secretion of IL-1β in vivo and in vitro and that this cytokine is critical for shaping a mucosal environment suited to helminth chronicity. Indeed in mice deficient for IL-1β (IL-1β(-/-, or treated with the soluble IL-1βR antagonist, Anakinra, helminth infection results in enhanced type 2 immunity and accelerated parasite expulsion. IL-1β acts to decrease production of IL-25 and IL-33 at early time points following infection and parasite rejection was determined to require IL-25. Taken together, these data indicate that Hp promotes the release of host-derived IL-1β that suppresses the release of innate cytokines, resulting in suboptimal type 2 immunity and allowing pathogen chronicity.

  8. Interleukin (IL)-13 and IL-4 inhibit proliferation and stimulate IL-6 formation in human osteoblasts: evidence for involvement of receptor subunits IL-13R, IL-13Ralpha, and IL-4Ralpha.

    Science.gov (United States)

    Frost, A; Jonsson, K B; Brändström, H; Ljunghall, S; Nilsson, O; Ljunggren, O

    2001-03-01

    Interleukin-13 (IL-13) inhibits cell proliferation and stimulates interleukin-6 (IL-6) formation in isolated human osteoblasts (hOBs). Because the related cytokine, interleukin-4 (IL-4), is known to exert effects similar to IL-13 in other tissues, and because IL-4 has been implicated as a regulator of bone metabolism, we compared the effects of IL-13 and IL-4 on cell proliferation, IL-6 synthesis, the expression of osteoblastic phenotypic markers in hOB cultures. Also, the receptor proteins mediating these effects in hOBs have been partly characterized. IL-4 and IL-13 dose-dependently inhibited [(3)H]-thymidine incorporation into the DNA of human osteoblasts and stimulated secretion of IL-6 into culture supernatants. IL-13 and IL-4 also increased the mRNA levels of IL-6, as measured by RNAse protection assay. Furthermore, IL-13 and IL-4 dose-dependently enhanced alkaline phosphatase (ALP) activity, but did not affect osteocalcin or collagen type I synthesis. IL-4 was tenfold more potent than IL-13 in inducing both ALP activity and IL-6 secretion, whereas the cytokines were equipotent as inhibitors of cell proliferation. The expression of mRNA for receptor subunits previously implicated in IL-4 and IL-13 signaling was investigated by reverse transcriptase-polymerase chain reaction. IL-13R, IL-13Ralpha, and IL-4Ralpha mRNA were repeatedly detected in hOBs, whereas mRNA for IL-2Rgamma(C) was not detected. Receptor-blocking antibodies to IL-4Ralpha inhibited the induction of IL-6 formation by both IL-4 and IL-13, indicating that both cytokines utilize this receptor subunit in signaling. However, the antibodies did not affect the IL-4/-13-induced inhibition of [(3)H]-thymidine incorporation or the stimulation of alkaline phosphatase (ALP), suggesting that IL-4Ralpha does not mediate these effects of IL-4/-13 in hOBs. We conclude that the cytokines IL-13 and IL-4, through sharing of receptor components, induce similar effects on hOBs, causing inhibition of cell

  9. Data on interleukin (IL)-2- and IL-15-dependent changes in IL-2Rβ and IL-2Rγ complexes

    DEFF Research Database (Denmark)

    Osinalde, Nerea; Sánchez-Quiles, Virginia; Blagoev, Blagoy

    2017-01-01

    -specific phosphorylation events observed both in IL-2Rβ and IL-2Rγ. Moreover, we provide results demonstrating the specific protein recruitment capacity of four of those site-specific phosphorylations. The proteomics and phosphoproteomics data described in this article is associated with a research article entitled...

  10. Atenuación de intensidades sísmicas en el territorio colombiano

    Directory of Open Access Journals (Sweden)

    Coral Gómez Carlos

    1995-10-01

    Full Text Available By means of using isoseismal map of the strong Colombian earthquakes, attenuation coefficients sand c of the Shebalin macroseismic formula (1968 were found. Computations were performed measuring the mean radius of isoseismal axes, according to the Shebalin macroseismic field method. The obtained c values have a relative broad of variation, from 0.5 to 13.9; and the found s values change from 3.3 to 7.0. Dispersion in the observed coefficient values seem to be related to the tectonic complexity and anisotropy of the Colombian territory medium which strongly aHects the propagation of seismic energy.

    Con base en los mapas de isosistas existentes para los terremotos ocurridos en el territorio colombiano, se han encontrado valores del coeficiente de atenuación para las zonas sismoactivas del país. EI cálculo de los coeficientes de atenuación s y c se hizo para los terremotos cuyo esquema de isosistas contiene no menos de tres isolíneas. Este cálculo se hizo midiendo la longitud media del eje a lo largo de la extensión de las isosistas, utilizando la fórmula del campo macrosísmico propuesta por Shebalín (1968 y aplicando el método de los mínimos cuadrados. Los valores de c obtenidos varían dentro de un intervalo muy grande de 0.5 a 13.9. La variación del coeficiente se encuentra en el rango de 3.3 a 7.0. La dispersión de estos valores parece estar relacionada con la complejidad tectónica del territorio colombiano, lo cual influye notable mente en la forma como se propagan las ondas sísmicas.

  11. Territorios agrarios y realidades rururbanas: Reflexiones sobre el desarrollo rural a partir del caso pampeano bonaerense

    Directory of Open Access Journals (Sweden)

    Silvia Gorenstein

    2007-12-01

    Full Text Available El debate sobre el desarrollo rural ha sufrido una fuerte renovación derivada de las transformaciones de la agricultura, y de las economías y sociedades rurales. En este contexto, se observa una visión ampliada del medio rural integrando complejos rururbanos de encadenamientos relacionados con la producción y el consumo local-regional, destacándose además la importancia de las ocupaciones no agrícolas como fuente de ingresos adicionales de hogares rurales. Este artículo explora estos aspectos en la provincia de Buenos Aires, principal espacio agroproductivo de la región pampeana argentina. Se examinan la combinación de las tendencias poblacionales y de la configuración rural-urbana; las características de los territorios que son asiento real o potencial de estrategias pluriactivas de la población rural; los entramados institucionales que acompañan redefiniciones en la governance de estos territorios. A la luz de estos elementos, se presentan algunos puntos de reflexión para la formulación de políticas de desarrollo ruralThe debate on rural development has undergone a strong renewal due to transformations in agriculture, and in rural economies and societies. In this context, a broader vision of the rural medium has been observed, which includes rururban spaces where services and supply chains relating to local and regional production and consume are located. Ofparticular importance are non-agricultural occupations as additional income sources for rural homes. This paper explores these issues in the province of Buenos Aires -the main area of agricultural production in the pampeana region of Argentina-. Some of the features analyzed here are population trends and the rural-urban configuration; the characteristics of the territories that are potential or real bases for pluriactive strategies by the rural population; and the characteristics of the institutional webs that accompany redefinitions of territorial governance. In light of

  12. Identificación de territorios críticos en salud materna mediante indicadores

    Directory of Open Access Journals (Sweden)

    Paz Ballivián Marcos

    2002-01-01

    Full Text Available Objetivos. El Ministerio de Salud y Previsión Social de Bolivia convocó a principios de 2000 a varios expertos para que, a partir de la información disponible, elaboraran un método que permitiera identificar territorios críticos en un tema de por sí prioritario --la salud materna y neonatal-- y crear un mapa de la situación y de la capacidad instalada en las 112 provincias nacionales. En este estudio se describe el método utilizado. Métodos. Se crearon índices de la situación de salud y de la capacidad instalada. Los pasos seguidos en este proceso fueron los siguientes: 1 identificación de las variables incluidas en cada índice; 2 ponderación de las variables de cada índice; creación de una fórmula para cada índice; 4 elaboración de una planilla con los datos de cada provincia correspondientes a las variables elegidas y al valor porcentual provincial de cada índice, obtenido mediante la aplicación de la respectiva fórmula; 5 identificación de tres categorías continuas para cada índice, y 6 definición de la taxonomía. Resultados. De este modo, se obtuvo un mapa nacional de la situación de salud materna y de la capacidad instalada en cada una de las 112 provincias bolivianas, lo cual permitió seleccionar un número mínimo de provincias para realizar intervenciones conjuntas entre el Ministerio de Salud y Previsión Social y otras instituciones. Las 9 provincias seleccionadas tienen un total de 26 municipios que implican a 17 distritos sanitarios y concentran el 29% de la población del país, el 33% de las muertes maternas y el 35% de las defunciones neonatales tempranas estimadas. Conclusiones. Basándose en información disponible, el método utilizado proporcionó un mapa de la situación global, en este caso de la salud materna, de las 112 provincias de los 9 departamentos bolivianos que permite identificar territorios críticos para las intervenciones en materia de salud.

  13. Identificación de territorios críticos en salud materna mediante indicadores

    Directory of Open Access Journals (Sweden)

    Marcos Paz Ballivián

    2002-07-01

    Full Text Available Objetivos. El Ministerio de Salud y Previsión Social de Bolivia convocó a principios de 2000 a varios expertos para que, a partir de la información disponible, elaboraran un método que permitiera identificar territorios críticos en un tema de por sí prioritario --la salud materna y neonatal-- y crear un mapa de la situación y de la capacidad instalada en las 112 provincias nacionales. En este estudio se describe el método utilizado. Métodos. Se crearon índices de la situación de salud y de la capacidad instalada. Los pasos seguidos en este proceso fueron los siguientes: 1 identificación de las variables incluidas en cada índice; 2 ponderación de las variables de cada índice; creación de una fórmula para cada índice; 4 elaboración de una planilla con los datos de cada provincia correspondientes a las variables elegidas y al valor porcentual provincial de cada índice, obtenido mediante la aplicación de la respectiva fórmula; 5 identificación de tres categorías continuas para cada índice, y 6 definición de la taxonomía. Resultados. De este modo, se obtuvo un mapa nacional de la situación de salud materna y de la capacidad instalada en cada una de las 112 provincias bolivianas, lo cual permitió seleccionar un número mínimo de provincias para realizar intervenciones conjuntas entre el Ministerio de Salud y Previsión Social y otras instituciones. Las 9 provincias seleccionadas tienen un total de 26 municipios que implican a 17 distritos sanitarios y concentran el 29% de la población del país, el 33% de las muertes maternas y el 35% de las defunciones neonatales tempranas estimadas. Conclusiones. Basándose en información disponible, el método utilizado proporcionó un mapa de la situación global, en este caso de la salud materna, de las 112 provincias de los 9 departamentos bolivianos que permite identificar territorios críticos para las intervenciones en materia de salud.

  14. DE LOS DERECHOS INDÍGENAS A LA IDENTIDAD Y AL TERRITORIO HACIA EL DERECHO A LA AUTODETERMINACIÓN

    Directory of Open Access Journals (Sweden)

    Maria Angélica Albuquerque Moura Oliveira

    2016-10-01

    Full Text Available Se ha centrado en los derechos indígenas a la identidad , al territorio y a la autodeterminación, tanto a nivel nacional (CF/88 , como a nivel internacional (Convenio 169 de la OIT ; Declaración de las Naciones Unidas sobre los Derechos de los Pueblos Indígenas. Las categorías de análisis identidad y territorialidad integran el principio de auto-identificación, que fue ampliado por el concepto de autodeterminación. Em conclusión, el reconocimiento de los derechos a la identidad y el territorio son el comienzo de la ciudadanía indígena, lo que requiere el pleno reconocimiento de la libre determinación de estos pueblos.

  15. Study on the changes of serum IL-2, IL-6, IL-8 and TNF levels in patients with diabetic nephrosis

    International Nuclear Information System (INIS)

    Qin Wenjing

    2005-01-01

    Objective: To investigate the changes of serum IL-2, IL-6, IL-8 and TNF levels in patients with diabetic nephrosis. Methods: Serum IL-2, IL-6, IL-8 and TNF levels were measured with RIA in 38 patients with diabetic nephrosis and 36 controls. Results: Serum levels of IL-6, IL-8 and TNF were significantly higher in patients with diabetic nephrosis than those in controls (P<0.01), but serum IL-2 levels were significantly lower in the patients (P<0.01). Conclusion: These cytokines participated in the pathogenesis of diabetic nephrosis. Monitoring the changes of their serum levels was helpful for the management of the disease. (authors)

  16. Video e comunicazione scientifica. Il laboratorio MELA dell’Università di Bologna

    Directory of Open Access Journals (Sweden)

    Laura Corazza

    2010-07-01

    Full Text Available Al Media Education e-learning LAboratorio del Dipartimento di Scienze dell’educazione e della Facoltà di Scienze della formazione, Università di Bologna, un gruppo di esperti e di tecnici svolge attività di supporto alla didattica e alla ricerca, lavorando con i docenti per produrre audiovisivi e materiali multimediali. I prodotti MELA sono video per l’approfondimento culturale, per la produzione scientifica, per la documentazione.

  17. Agendas concurrentes en la titulación colectiva del territorio en Awastingni y Bosawas, RAAN, Nicaragua

    Directory of Open Access Journals (Sweden)

    Claudia Liza Corona De La Peña

    2013-10-01

    Full Text Available En la Costa Atlántica nicaragüense se vive un proceso de reconocimiento de la propiedad colectivade los pueblos indígenas sobre sus territorios. Este proceso responde a una fuerte demanda yorganización de los costeños pero, al mismo tiempo, ha sido impulsado por organismos multilateralescomo el Banco Mundial. El caso de la comunidad de Awastingni en la Región Autónoma del AtlánticoNorte (RAAN, es central en el tema de la titulación colectiva del territorio ya que, luego de un arduoproceso jurídico, esta comunidad logró una sentencia que obligaba al Estado a reconocer su territorioy a finales de 2008 le fue otorgado el título de propiedad sobre el 70% de la superficie reclamada. Conbase en la información recabada en campo, observamos que Awastingni contrasta en varios aspectoscon la experiencia de los primeros territorios indígenas legalmente reconocidos ubicados dentro de laReserva de la Biosfera de Bosawas pero, en ambos casos, el Banco Mundial jugó un papel fundamental.Un recuento de ambas experiencias nos permitirá analizar los retos que conllevan el reconocimientode los territorios indígenas en el marco de la actual legislación sobre demarcación y titulación de territoriosindígenas en Nicaragua, del sistema interamericano de derechos humanos y de la actuaciónde los organismos multilaterales.

  18. La educación ambiental y su importancia en la relación sustentable: Hombre-Naturaleza- Territorio

    Directory of Open Access Journals (Sweden)

    Ronald Fernando Quintana Arias

    2017-01-01

    Full Text Available Objetivo. Promover la importancia de la educación ambiental en el fortalecimiento de la relación sustentable Hombre-Naturaleza-Territorio en 8 niños y niñas observadores de aves de la primaria María Berchmans. Metodología. Entre agosto y noviembre del 2015 desarrollé un estudio de caso basado en el aprendizaje vivencial, social y experiencial, que se dividió en dos fases en las que se encontraban 19 actividades clasificadas dentro de siete categorías. Resultados. El desarrollo tanto de habilidades cognitivas “duras” como de habilidades socioemocionales “blandas” exponiendo diferentes ambientes educacionales, incentiva un aprendizaje activo que fortalece la relación sustentable Hombre-Naturaleza-Territorio. Conclusión. La generación de una conciencia de conservación ambiental al contemplar la importancia de la educación escolar en la relación Hombre-Naturaleza-Territorio lleva a la apropiación de la biodiversidad (natural-cultural y a generar aprendizajes significativos.

  19. TERRITORIOS SOLIDARIOS DE AMÉRICA LATINA Y TURISMO COMUNITARIO EN REBOTE A LOS MEGA EMPREEMDIMENTOS TRANSNACIONAL

    Directory of Open Access Journals (Sweden)

    Luzia Neide Coriolano

    2013-07-01

    Full Text Available Este estudio analiza territorios solidarios de turismo comunitario en países de América Latina como un contrapunto al turismo convencional, de los mega emprendimientos transnacionales. Cambios en el modelo socioeconómico con movimientos de resistencia a la supuesta hegemonía de los países ricos, superposiciones de  megaempresas a la de pequeña escala, en relación al turismo global, convencional, dedicado a los mega emprendimientos vinculados con la especulación inmobiliaria. Verifica como países fortalecen territorios de economías solidarias, comunitarias. Como se crean sinergias, socialización de conocimientos en territorios como una forma de reducir las disparidades espaciales y las desigualdades sociales. Identifica experiencias con referencia de políticas de inclusión social, que promueven pequeñas ciudades, barrios, suburbios y comunidades, mitigan distancias entre ricos y pobres. Articulaciones entre aspectos políticos e institucionales para gestiones participativas y estrategias como cuestiones ambientales y de sostenibilidad socio-económica y desarrollo de comunidades que buscan soluciones económicas y sociales por el turismo, en América Latina.

  20. TERRITORIO Y PSICOLOGÍA SOCIAL Y COMUNITARIA, TRAYECTORIAS/IMPLICACIONES POLÍTICAS Y EPISTEMOLÓGICAS

    Directory of Open Access Journals (Sweden)

    Santiago Conti

    Full Text Available RESUMEN "Territorio" es un concepto originado en el campo disciplinar de la Geografía, que a lo largo del siglo XX ha ido reformulándose según las distintas corrientes del pensamiento social. Es factible reconocer que en la actualidad dicho concepto ha trascendido su ámbito disciplinar y es utilizado profusamente en el campo de las ciencias sociales, en general, y en la Psicología Social y Comunitaria, en particular. Trascendiendo el encuadre disciplinar de la geografía, el presente trabajo se propone realizar un recorrido analítico para comprender las implicancias políticas y epistemológicas que supone el uso del concepto "territorio" para la Psicología Social y Comunitaria. Se sostendrá que lejos de lo que los recortes disciplinares efectúan, "territorio" es un concepto que no está ni ha estado alguna vez exento de determinados supuestos psicosociales; supuestos que desde el presente artículo serán evidenciados considerando las íntimas relaciones entre las disciplinas en cuestión.

  1. IL CAMPO GEOMAGNETICO

    Directory of Open Access Journals (Sweden)

    F. MOLINA

    1972-06-01

    Full Text Available Questo lavoro non è un trattato sul campo geomagnetico e nemmeno
    una rassegna sull'argomento, almeno nel significato che normalmente
    si attribuisce al termine « rassegna »; esso è semplicemente
    un tentativo di condensare in termini comprensibili agli studiosi non
    specializzati ciò che oggi si sa o si ipotizza sul magnetismo terrestre
    e sulle sue cause. Chi scrive si è sempre trovato a disagio di fronte
    alle richieste di una spiegazione sull'origine del campo magnetico
    terrestre: o si cerca di cavarsela con poche parole (« si tratta di correnti
    elettriche indotte nell'interno della Terra » che possono forse accontentare
    chi non si occupa in modo particolare di problemi scientifici
    ma non possono soddisfare un fisico, oppure ci si sente obbligati a
    tentare faticosamente di approfondire, sia per capirli personalmente
    che per poterli poi spiegare agli altri, argomenti e ragionamenti che
    sono in realtà accessibili solo a un fisico teorico ben preparato. Apparentemente
    non esiste una via di mezzo, come del resto in molti altri
    campi della fisica contemporanea.
    La presente monografia rappresenta appunto il tentativo di trovare
    questa via di mezzo: nel terzo capitolo, dedicato alle teorie sull'origine
    del campo geomagnetico, si cerca di descrivere qualitativamente
    i principali processi fisici proposti come sorgenti del campo,
    dopo un accenno ai fondamenti fisici e matematici sui quali sono state
    elaborate le varie teorie. Senza farmi soverchie illusioni di essere riuscito
    nell'intento, mi dichiarerei tuttavia soddisfatto se questo lavoro
    destasse sull'argomento l'interesse di qualche giovane ricercatore, incoraggiandolo
    ad un approfondimento.

  2. IL FENOMENO DELL’ALTERNANZA L1/L2 NELL’INSEGNAMENTO DELL’ITALIANO COME LINGUA STRANIERA. ANALISI DI UN CORPUS DI INTERAZIONI DIDATTICHE

    Directory of Open Access Journals (Sweden)

    Paola Arrigoni

    2012-02-01

    Full Text Available La modalità plurilingue della comunicazione in classi di lingua straniera può rientrare tra le strategie pedagogiche a disposizione dell’insegnante per il raggiungimento di precisi scopi didattici e formativi. Partendo da una breve analisi sul significato di parlante plurilingue e plurilinguismo stesso, in questo articolo si è voluto esaminare come si attua una educazione al plurilinguismo in contesti formativi e, in particolare, se e come l’utilizzo della L1 può costituire uno strumento di supporto all’insegnamento e all’apprendimento di una lingua straniera. A questo scopo sono stati analizzati i dati raccolti presso l’Università di Coventry durante corsi di italiano L2 per studenti anglofoni. I fenomeni di contatto linguistico L1/L2 più frequenti e significativi sono stati suddivisi in base al parlante e alle loro funzioni.   The phenomena of l1/l2 alternation in the teaching of italian as a foreign language. analysis of a corpus of didactic interactions Multilingual communication in foreign language classrooms can be considered as one of the teacher’s pedagogical  strategies to achieve specific educational aims. Through a brief analysis of the meaning of multilingual speakers and multilingualism, this article examines how an education to multilingualism in teaching contexts is carried out and, in particular, if and how the use of the L1 can be a helpful tool for the foreign language teaching and learning. For this purpose the data collected at Coventry University during Italian (L2 classrooms for English students were examined. The more common and meaningful phenomena of linguistic contact between L1 and L2 were grouped according to the speaker and to their functions.

  3. El debate sobre los territorios inteligentes: el caso del área metropolitana de Sevilla

    Directory of Open Access Journals (Sweden)

    INMACULADA CARAVACA BARROSO

    2009-08-01

    Full Text Available Los cambios profundos y rápidos que están experimentando las sociedades, las economías y las lógicas territoriales durante las últimas décadas, demandan nuevas lecturas e interpretaciones por parte de los investigadores y nuevas respuestas de los responsables públicos para poder hacer frente a los problemas y retos que ahora se perfilan. En este contexto general de referencia, el objetivo de este artículo es participar en el debate sobre el concepto de territorio inteligente, aunando la perspectiva economicista con aquella otra más ligada a la idea de desarrollo territorial integrado. Ello, a través del análisis de la evolución experimentada por el área metropolitana de Sevilla, realizado con esta doble mirada.The fast and deep transformations experienced by the societies, the economies and the spatial patterns during the last decades, demands that researchers make new interpretations and public managers come up with new answers to face the current problems and challenges. In this general context, the purpose of this article is to participate of the debate about the concept of intelligent territory, combining economicist approaches with others ones related to the idea of integrated territorial development. In order to achieve this aim the evolution experienced by the metropolitan area of Sevilla will be analyzed, using this double approach.

  4. NOMBRES EN EL PAISAJE: LA TOPONIMIA, FUENTE DE CONOCIMIENTO Y APRECIO DEL TERRITORIO

    Directory of Open Access Journals (Sweden)

    Pascual Riesco Chueca

    2010-01-01

    Full Text Available Se recorre aquí en dos sentidos un camino que conduce de los nombres al paisaje, y del paisaje a los nombres. Estas flotantes nubes verbales -los topónimos- que acompañan, y a veces suplantan, a la realidad, son capaces de transformar con su leve peso las evidencias de lo material. El mecanismo de fijación de los nombres de lugar explica su relevancia como indicadores de paisaje. La densidad toponímica es un dato esencial: si es alta, avisa de una densidad homóloga en los usos y la historia del lugar. Se pasa revista a los topónimos como expresión de cultura y biogeografía, tradición oral y literatura. Se distinguen dos dimensiones en cierto modo antagónicas del nombre de lugar: su carácter hereditario, pero también su posible imposición, por razones simbólicas o de poder. Finalmente, se valoran posibilidades de puesta en valor de la toponimia en la disciplina del paisaje, y se discute el influjo de las nuevas denominaciones y rotulaciones sobre la experiencia del territorio.

  5. Del territorio a la empresa: conocimientos productivos entre los ingenieros del norte de México

    Directory of Open Access Journals (Sweden)

    Alfredo Hualde Alfaro

    2001-01-01

    Full Text Available El crecimiento del empleo industrial con el aumento de la inversión extranjera ha producido un incremento de los mercados profesionales de ingenieros en las ciudades del norte de México. En los casos a los que el artículo se refiere, dicho crecimiento es mucho más importante en Tijuana que en Hermosillo. En una época de valoración creciente del conocimiento, la pericia y las competencias para el desarrollo local y regional, es necesario preguntarse por la naturaleza de dichos conocimientos, la forma de transmisión de los mismos y los actores e instituciones que intervienen en la producción y reproducción de los conocimientos productivos. El artículo toma el caso de las maquiladoras de Tijuana y de la empresa Ford de Hermosillo con el objetivo de reflexionar acerca de la forma en que dichos conocimientos constituyen (o no nexos de articulación entre las empresas y el territorio.

  6. Grupos étnicos de Sonora: territorios y condiciones actuales de vida y rezago

    Directory of Open Access Journals (Sweden)

    José Luis Zárate Valdez

    2016-01-01

    Full Text Available En el presente artículo se ofrece una caracterización breve de los territorios y condiciones en que viven los gru - pos indígenas que habitan en el estado de Sonora, a partir de su historia. Además, se plasma su situación actual en indica - dores territoriales, demográficos, actividades económicas, educación, vivienda, salud y rezago social. En Sonora hay nueve grupos étnicos, integrados por alrededor de 138 mil personas, lo que representa 5.2 por ciento de la población total de la entidad. En conjunto, poseen 5.8 por ciento de la superficie estatal, aunque en áreas desérticas, montañosas, de difícil acceso y, en algunos casos, la comparten con gente no indígena. Ochenta por ciento de estos grupos vive en comunidades rurales, por lo general alejadas de los centros urbanos, con acceso insuficiente a la educación y a los ser - vicios médicos, con fuentes de trabajo de bajo perfil y paga, viviendas pequeñas con pocos bienes y carentes de electricidad, drenaje y agua potable de calidad. Los indicadores analizados confirman el estado de marginación, vulnerabilidad y fragilidad de este sector de la población, y marcan la necesidad urgente de apoyo real de parte del Estado.

  7. ESTUDIOS PARA EL PLAN DE ACCESIBILIDAD A TERRITORIOS DE SIMILAR IDENTIDAD: ESTADO DE BAHIA

    Directory of Open Access Journals (Sweden)

    José Lázaro de Carvalho Santos

    2012-01-01

    Full Text Available El Estado de Bahía tiene una extensión territorial comparable a algunos países menores que Brasil. Por lo tanto existen grandes disparidades regionales, que concentran el desarrollo económico e inversiones en infraestructura en la Región Metropolitana de Salvador. Algunas regiones tienen bajos índices de desarrollo económico y social y necesidad de infraestructura y servicios de transporte público colectivo a nivel interurbano y regional. El Gobierno de Bahía, a través de la Secretaría de Desarrollo Urbano, SEDUR, está elaborando un Plan de Accesibilidad Regional y Municipal para los centros urbanos de los Territorios de Itaparica, Semiárido Nordeste II y Sisal. El objeto de este trabajo es explicar los resultados de estos estudiosya realizados, difundiendo el conocimiento sobre las condiciones de accesibilidad de los municipios que están en la región más pobre de Bahía.

  8. APORTES PARA EL ESTUDIO DEL TERRITORIO: LOS NAHUAS DE ZONGOLICA VERACRUZ

    Directory of Open Access Journals (Sweden)

    MARTHA INÉS FLORES PACHECO

    2014-10-01

    Full Text Available El estudio sobre el tema del territorio indígena es muy amplio y puede analizarse desde diferentes perspectivas teórico metodológicas, no obstante, este artículo lo aborda principalmente desde el enfoque de la antropología y el trabajo etnográfico. La región de estudio es la zona nahua de Zongolica donde se está realizando el proyecto de investigación intitulado: Políticas sociales y Pueblos Indígenas; turismo y patrimonio histórico, cultural y natural de la Región de las Montañas, Veracruz. En el presente artículo se exponen los avances de la revisión teórica sobre la territorialidad indígena y su vinculación con la cosmovisión indígena, los derechos indígenas y el patrimonio histórico cultural y natural, territorialidad que está siendo violentada por otros grupos sociales y acciones de desarrollo promovidas por el Estado Mexicano.

  9. Salinas de interior en el territorio de la Región de Murcia

    Directory of Open Access Journals (Sweden)

    S. Gil Guirado

    2010-01-01

    Full Text Available La sal es un elemento necesario en la actividad de los grupos humanos. Para su captación y recolección se ha ordenado el territorio, con unos paisajes propios: las salinas. Podemos distinguir dos tipos: las salinas costeras y las salinas de interior. En estas últimas, su localización y explotación está ligada a la presencia de algún material salino que atraviesa el agua. En ellas se pueden distinguir tres áreas, la de captación del agua (generalmente pozos horizontales del tipo minado o galería; la de almacenaje (con balsas y recocederos dónde acumular y calentar; y finalmente la de cristalización (con parcelas más o menos aterrazadas conocidas como eras. A través del estudio combinado del trabajo de campo y la documentación de archivos, hemos podido localizar una veintena de salinas en el interior de la Región de Murcia; huella de una actividad económica y de una cultura del agua entre la variedad de paisajes surestinos.

  10. Territorio mediático-educativo en Suecia Media education landscape in Sweden

    Directory of Open Access Journals (Sweden)

    María Bergman

    2007-03-01

    Full Text Available Conocer el «territorio mediático educativo» en Suecia, a partir de la perspectiva presentada por la catedrática y pedagoga Birgitta Qvarsell, es el objetivo de este trabajo, que reflexiona sobre la ciencia pedagógica de los medios, «media educology». Basado en el contexto sueco, nos ofrece un análisis global relacionando el impacto y desarrollo de la técnica con los medios de comunicación, reseñando sus influencias en la pedagogía y la educación, contando para ello con todos los actores de este impacto mediático. El trabajo recoge también datos de un reciente informe del Consejo de Medios del Departamento de Cultura sueco, titulado «Los jóvenes y los medios». In this paper we describe the Swedish media education landscape and Brigitta Qvarsell‘s perspective on the influence of technological development in media education in Swedish context. Results of data collection about the media consumption by children and young Swedish people are also included. The conclusion remarks the need for a new area with ethnographic and semiotic basis: media educology.

  11. Diabetes y su impacto en el territorio periodontal Diabetes and its impact in periodontal tissues

    Directory of Open Access Journals (Sweden)

    P Smith

    2012-08-01

    Full Text Available Diabetes y enfermedad periodontal corresponden probablemente al mejor ejemplo de cómo una enfermedad sistémica puede tener un efecto en el territorio periodontal. Si bien esta asociación ha sido extensamente estudiada, muchas de las asociaciones propuestas presentan contradicciones. En la presente revisión de la literatura se analizan los siguientes tópicos relevantes para la práctica clínica en periodoncia e implantología: i Identificación de enfermedad periodontal severa y su capacidad para diagnosticar casos de diabetes; ii Efectos de la diabetes sobre la enfermedad periodontal; iii Efectos de la diabetes sobre la reparación periodontal y periimplantaria; iv Efecto del tratamiento periodontal sobre el control metabólico de la diabetes.Diabetes and periodontal disease correspond to conditions that probably exemplify how a systemic disease may have a strong impact in the periodontium. Although this association has been studied for several years, many of these studies still show contradictory results. The present review analyses the following questions relevant for the clinician in the fields of periodontology: i Value of the diagnosis of severe periodontitis and its capacity to identify previously un-diagnosed cases of diabetes; ii Effects of diabetes on periodontal disease; iii Effects of diabetes on periodontal and peri-implant tissue repair and regeneration and; iv Effect of periodontal therapy on the metabolic control of diabetes.

  12. Candice Lin: paisaje, territorio y fronteras (Candice Lin: Landscape, Territory and Boundaries

    Directory of Open Access Journals (Sweden)

    Gabriel Baltodano Román

    2017-11-01

    Full Text Available Se analizan los contenidos ideológicos de la acuarela «Nacimiento de una nación» (2008, de Candice Lin. A partir de nociones como territorio, tropo caníbal, tipo botánico tropical y pensamiento fronterizo, se plantea una interpretación de esa paisajística pictórica, en que la artista-activista reflexiona sobre el régimen de representación visual. Mediante diversos procedimientos formales, Lin pone en entredicho preceptos centrales de la mentalidad colonialista, que contrapone a las concepciones indigenistas. Abstract An analysis is provided of the ideological contents of the watercolor “Birth of a Nation” (2008, by Candice Lin. This interpretation of this pictorial landscape is based on notions such as territory, cannibal tropes, tropical botanical types and border thinking. The artist activist reflects here on the regime of visual representation. Using different formal procedures, Lin questions central precepts of the colonialist mentality, in contrast with indigenous conceptions.

  13. Il discreto e il continuo complementarita in matematica

    CERN Document Server

    Kuyk, Willem

    1982-01-01

    Nato dall'esperienza didattica dell'autore, il libro si presenta come un testo interdisciplinare di matematica e di filosofia, inteso a fornire un quadro complessivo dello stato attuale dei fondamenti della matematica.

  14. Il collasso dell'Antartide

    OpenAIRE

    Florindo, F.; Boschi, E.

    2009-01-01

    Negli ultimi anni il problema del riscaldamento globale del nostro pianeta (global warming) e del contributo della civiltà moderna all’incremento dei livelli di gas serra ha assunto sempre più rilevanza nell’ambito della comunità scientifica e politica. Nel corso del XX secolo il riscaldamento medio globale è stato di 0.7°C e una delle ultime proiezioni attuate dal Comitato Intergovernativo sui Cambiamenti Climatici (Ipcc-2007) indica che entro il 2100 la temperatura sarà...

  15. Patrimonio y turismo sostenible desde la ordenación del territorio: el caso del Pirineo Aragonés

    Directory of Open Access Journals (Sweden)

    Bielza de Ory, Vicente

    2001-12-01

    Full Text Available It is tackled natural patrimony and cultural heritage of «Pirineo aragonés» analysis in relation to the tourism from a wide, integrater and complete view, as Geography has traditionally done and as E.U regional planning (E.T.E., 1999 and UNESCO (Monte Perdido, 1997 tends to do nowadays. Tourism evolution towards the sustainability, included in the Sustainable Tourism World Card (1995 requires its convergence with regional planning, especially in so fragile patrimonies as the mountain's are. In order to get it, more regional planning and patrimony regulations than the tourism ones exist in Aragon. Cultural park figure, increased by geographers and regulated with law rank in 1997 for every territory which counts with a natural patrimony wealth sited in a landscape of ecological or aesthetic value is a way to plan the territory, promoting a sustainable tourism. «Vero» river and «San Juan de la Peña» experiences are joined to the Leader programs, like «Sobrarbe-Ribagorza» to protect and, at the same time, promoting Pirineo region with tourism.

    Se aborda el análisis de los patrimonios natural y cultural del Pirineo aragonés en relación con el turismo desde una óptica amplia, integradora y holística, como tradicionalmente ha hecho la geografía y como tiende a hacer hoy la Ordenación del Territorio de la U.E.(E.T.E., 1999 y la UNESCO (Monte Perdido, 1997. La evolución del turismo hacia la sostenibilidad, recogida en la Carta Mundial del Turismo Sostenible(1995 exige su convergencia con la planificación territorial, máxime en patrimonios tan frágiles como los de montaña; para ello existen en Aragón más normas ordenadoras del territorio y del patrimonio que del turismo. La figura de parque cultural, ampliada por geógrafos y normativizada con rango de ley en 1997 a todo territorio que cuente con una riqueza de patrimonio cultural enclavada en un paisaje de valor ecológico o estético es una forma de ordenar el territorio

  16. IL6 and IL10 are genetic susceptibility factors of periodontal disease

    Directory of Open Access Journals (Sweden)

    Luca Scapoli

    2012-01-01

    Conclusions: The present investigation indicated that polymorphisms of IL6 and IL10 constitute risk factors for chronic periodontitis, while there was no evidence implicating a specific IL1A or IL1B genotype.

  17. Association study of functional polymorphisms in interleukins and interleukin receptors genes: IL1A, IL1B, IL1RN, IL6, IL6R, IL10, IL10RA and TGFB1 in schizophrenia in Polish population.

    Science.gov (United States)

    Kapelski, Pawel; Skibinska, Maria; Maciukiewicz, Malgorzata; Wilkosc, Monika; Frydecka, Dorota; Groszewska, Agata; Narozna, Beata; Dmitrzak-Weglarz, Monika; Czerski, Piotr; Pawlak, Joanna; Rajewska-Rager, Aleksandra; Leszczynska-Rodziewicz, Anna; Slopien, Agnieszka; Zaremba, Dorota; Twarowska-Hauser, Joanna

    2015-12-01

    Schizophrenia has been associated with a large range of autoimmune diseases, with a history of any autoimmune disease being associated with a 45% increase in risk for the illness. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopment, neuroplasticity and neurotransmission. In particular, increases or imbalance in cytokine before birth or during the early stages of life may affect neurodevelopment and produce vulnerability to the disease. A total of 27 polymorphisms of IL1N gene: rs1800587, rs17561; IL1B gene: rs1143634, rs1143643, rs16944, rs4848306, rs1143623, rs1143633, rs1143627; IL1RN gene: rs419598, rs315952, rs9005, rs4251961; IL6 gene: rs1800795, rs1800797; IL6R gene: rs4537545, rs4845617, rs2228145, IL10 gene: rs1800896, rs1800871, rs1800872, rs1800890, rs6676671; IL10RA gene: rs2229113, rs3135932; TGF1B gene: rs1800469, rs1800470; each selected on the basis of molecular evidence for functionality, were investigated in this study. Analysis was performed on a group of 621 patients with diagnosis of schizophrenia and 531 healthy controls in Polish population. An association of rs4848306 in IL1B gene, rs4251961 in IL1RN gene, rs2228145 and rs4537545 in IL6R with schizophrenia have been observed. rs6676671 in IL10 was associated with early age of onset. Strong linkage disequilibrium was observed between analyzed polymorphisms in each gene, except of IL10RA. We observed that haplotypes composed of rs4537545 and rs2228145 in IL6R gene were associated with schizophrenia. Analyses with family history of schizophrenia, other psychiatric disorders and alcohol abuse/dependence did not show any positive findings. Further studies on larger groups along with correlation with circulating protein levels are needed. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. El paisaje en la ordenación del territorio. La experiencia del Observatorio del Paisaje de Cataluña

    Directory of Open Access Journals (Sweden)

    Nogué, Joan

    2010-12-01

    Full Text Available Given the progressive degradation of our landscapes there is a need, on the one hand, to include the landscape in planning and, on the other, to raise public awareness of landscape values. To achieve this double goal, the year 2005 saw the creation of the Landscape Observatory of Catalonia, an independent public consortium that simultaneously acts as both an advisory body to the public authorities and an organisation that aims to raise society’s awareness of landscape-related issues. One of its main functions is to draw up landscape catalogues of Catalonia, an innovative tool for incorporating the landscape into planning and an element of town and country planning with regard to the implementation of landscape policy. The catalogues define the strategic lines and specific directives that can help improve landscape policy and, in short, the public’s quality of life.

    Ante la progresiva degradación de nuestros paisajes se hace necesario, por una parte, incluir el paisaje en la ordenación del territorio y, por otra, incrementar la sensibilización ciudadana sobre los valores del paisaje. Para conseguir este doble objetivo se creó en 2005 el Observatorio del Paisaje de Cataluña, un consorcio público independiente que actúa simultáneamente como entidad de asesoramiento de la Administración y como ente de concienciación de la sociedad en materia de paisaje. Una de sus principales funciones es la elaboración de los catálogos de paisaje de Cataluña, un instrumento novedoso para la incorporación del paisaje en la ordenación del territorio y un elemento clave para facilitar la conexión entre el planeamiento territorial y el urbanístico en lo referente a la implementación de políticas de paisaje. Los catálogos definen líneas estratégicas y directrices concretas que pueden contribuir a mejorar la calidad de los paisajes y, en definitiva, la calidad de vida de los ciudadanos. [fr] Devant la dégradation progressive de nos

  19. IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.

    Directory of Open Access Journals (Sweden)

    Paméla Gasse

    Full Text Available BACKGROUND: Idiopathic pulmonary fibrosis is a devastating as yet untreatable disease. We demonstrated recently the predominant role of the NLRP3 inflammasome activation and IL-1β expression in the establishment of pulmonary inflammation and fibrosis in mice. METHODS: The contribution of IL-23 or IL-17 in pulmonary inflammation and fibrosis was assessed using the bleomycin model in deficient mice. RESULTS: We show that bleomycin or IL-1β-induced lung injury leads to increased expression of early IL-23p19, and IL-17A or IL-17F expression. Early IL-23p19 and IL-17A, but not IL-17F, and IL-17RA signaling are required for inflammatory response to BLM as shown with gene deficient mice or mice treated with neutralizing antibodies. Using FACS analysis, we show a very early IL-17A and IL-17F expression by RORγt(+ γδ T cells and to a lesser extent by CD4αβ(+ T cells, but not by iNKT cells, 24 hrs after BLM administration. Moreover, IL-23p19 and IL-17A expressions or IL-17RA signaling are necessary to pulmonary TGF-β1 production, collagen deposition and evolution to fibrosis. CONCLUSIONS: Our findings demonstrate the existence of an early IL-1β-IL-23-IL-17A axis leading to pulmonary inflammation and fibrosis and identify innate IL-23 and IL-17A as interesting drug targets for IL-1β driven lung pathology.

  20. Espacio y capitalismo: la crisis capitalista, el territorio y las resistencias sociales

    Directory of Open Access Journals (Sweden)

    Santos Alonso Beltrán Beltrán

    2013-07-01

    Full Text Available La dimensión espacial se ha convertido en uno de los filones de análisis más importantes en el estudio de las dinámicas de acumulación capitalista. Sin embargo esto no se ha dado de manera fácil; por el contrario, las ciencias sociales se han ocupado de manera preferencial de la variable tiempo y han descuidado de manera sistemática la incidencia que el espacio puede tener en la construcción de las relaciones sociales de producción. La visión sobre el espacio ha estado dominada por un esencialismo centrado en su dimensión física, y su relación con el tiempo y los fenómenos sociales se ha reducido a verlo como un mero contenedor inerte y aislado. El papel jugado por el espacio en la reproducción del capital ha sido estratégicamente reducido en los discursos celebratorios de la globalización neoliberal, y la posibilidad de la resistencia territorializada, que haga un uso creativo y subversor de su relación con el lugar, descuidada por los movimientos de resistencia que han pensado que el combate se libra más en las agencias multilaterales, a veces creadas por los propios agentes del capital que impulsan la globalización excluyente, que en sus raíces con el territorio que han construido desde sus prácticas culturales, económicas, ecológicas y sociales. Finalmente, el texto busca resaltar la capacidad de resistencia que tienen los movimientos sociales, emplazados territorialmente, de enfrentar los embates de la globalización neoliberal y muestra en Colombia algunos ejemplos paradigmáticos en este camino.

  1. La sostenibilità finanziaria della cultura. Il caso delle istituzioni teatrali italiane / The financial sustainability of culture. The case of Italian theatres

    Directory of Open Access Journals (Sweden)

    Pier Luigi Sacco

    2011-12-01

    Full Text Available Il dibattito tra sostenitori del finanziamento pubblico all’arte e alla cultura e suoi oppositori ha origini lontane, ma mai come in questi mesi ha assunto un interesse così profondo, in funzione di un fondamentale trade-off che si acuisce sempre più: la restrizione dei budget di spesa a disposizione degli Stati occidentali da un lato, e i benefici sempre più marcati, anche di natura economica, che nuovi studi sembrano attribuire agli investimenti in arte e cultura dall’altro. Tramite un’analisi effettuata sui principali teatri italiani in termini di ricavi generati, il paper comprova l’impossibilità per le istituzioni culturali di potere conciliare in modo autonomo la propria mission di fondo con principi di sostenibilità finanziaria. Gli autori sostengono che il supporto al settore cultura rappresenta attualmente un’attività imprescindibile per uno Stato, non solo in funzione del carattere di meritorietà del bene culturale, ma soprattutto alla luce anche dei vantaggi di tipo economico, fino a pochi anni fa trascurati o meglio, difficilmente quantificabili, che la cultura è in grado di apportare per l’economia del «Sistema Paese»; vantaggi la cui quantificazione sarà possibile grazie al rapido sviluppo di metodologie valutative di prossima utilizzabilità.   Debates between advocates of public financing to arts and culture and its opponents have far-off roots, but they never gained such an importance like in these months, because of a crucial trade-off that has been exacerbating more and more: from the one hand, budget allowance restrictions available to Western States; on the other hand, the even more marked benefits – also in economic terms – that new studies attribute to investments in arts and culture. Through an analysis conducted on the main Italian theatres as for ticket sales, the paper proves the impossibility for the cultural institutions to mesh autonomously their main mission with financial sustainability

  2. Quantitative Contribution of IL2Rγ to the Dynamic Formation of IL2-IL2R Complexes.

    Directory of Open Access Journals (Sweden)

    Luis F Ponce

    Full Text Available Interleukin-2 (IL2 is a growth factor for several immune cells and its function depends on its binding to IL2Rs in the cell membrane. The most accepted model for the assembling of IL2-IL2R complexes in the cell membrane is the Affinity Conversion Model (ACM. This model postulates that IL2R receptor association is sequential and dependent on ligand binding. Most likely free IL2 binds first to IL2Rα, and then this complex binds to IL2Rβ, and finally to IL2Rγ (γc. However, in previous mathematical models representing this process, the binding of γc has not been taken into account. In this work, the quantitative contribution of the number of IL2Rγ chain to the IL2-IL2R apparent binding affinity and signaling is studied. A mathematical model of the affinity conversion process including the γ chain in the dynamic, has been formulated. The model was calibrated by fitting it to experimental data, specifically, Scatchard plots obtained using human cell lines. This paper demonstrates how the model correctly explains available experimental observations. It was estimated, for the first time, the value of the kinetic coefficients of IL2-IL2R complexes interaction in the cell membrane. Moreover, the number of IL2R components in different cell lines was also estimated. It was obtained a variable distribution in the number of IL2R components depending on the cell type and the activation state. Of most significance, the study predicts that not only the number of IL2Rα and IL2Rβ, but also the number of γc determine the capacity of the cell to capture and retain IL2 in signalling complexes. Moreover, it is also showed that different cells might use different pathways to bind IL2 as consequence of its IL2R components distribution in the membrane.

  3. The integration of physical and digital urban infrastructures: the role of “Big data”

    Directory of Open Access Journals (Sweden)

    Cinzia Talamo

    2016-06-01

    Full Text Available Le molte evoluzioni nell’ambito della gestione delle informazioni, l’affermarsi dei concetti di Big Data e IoT (internet of things, lo sviluppo e la diffusione della sensoristica stanno aprendo a innovativi scenari e delineando nuove questioni rispetto alle attività conoscitive e decisionali, con declinazioni specifiche se considerate in relazione all’ambito applicativo delle infrastrutture e dei beni edilizi e urbani. A partire da queste premesse, obiettivo del paper è delineare l’attuale quadro dei fattori tecnologici di innovazione e proporre alcune ipotesi circa i potenziali scenari futuri dei servizi di supporto alla gestione e allo sviluppo del territorio e dei manufatti edilizi a partire da diverse possibili forme di integrazione tra infrastrutture urbane fisiche e digitali. Nell’ambito delle infrastrutture, l’analisi del ruolo dell’informazione rispetto all’interazione tra materiale e immateriale pone una serie di questioni interpretative che il paper tratteggia. 

  4. Derechos colectivos y consulta previa: territorio cucapá y recursos pesqueros en Baja California, México

    Directory of Open Access Journals (Sweden)

    Alejandra Navarro Smith

    2014-07-01

    Full Text Available Las demandas de reconocimiento de derechos territoriales y de uso de los recursos naturales que los pescadores cucapás le hacen al Estado mexicano, desde 1993, después de la creación de la Reserva del Alto Golfo de California y Delta del Río Colorado (en adelante, la Reserva, son unas más en el panorama de los problemas socioambientales y de despojo territorial, que afectan a los pueblos originarios en México. La característica particular en este caso es que el Estado mismo es quien construye los marcos legales en materia de protección a las especies —sin consultar debidamente a dichos pueblos—, volviendo ilegal la presencia cucapá en esa zona y vulnerando sus derechos como población indígena del delta. En consecuencia, las autoridades medioambientales y de pesca mexicanas han constituido la zona del delta del río Colorado como un territorio en disputa, al implementar esquemas de protección ambiental y de pesca, sustentados en modelos disciplinarios, que únicamente se alimentan de información biológica y pesquera. El conflicto se genera cuando se deja al elemento humano fuera de los análisis, como si las comunidades asentadas en los territorios protegidos y usuarias de los recursos no formaran parte de los ecosistemas. Al crear el núcleo de la Reserva en el mismo lugar donde se encontraban los campamentos de pesca del pueblo cucapá se volvió ilegal el aprovechamiento de los recursos pesqueros en la zona. En este contexto se han criminalizado las acciones de resistencia con las que los cucapás responden ante la regulación medioambiental del delta del río Colorado. Al ver imposibilitada la continuidad de su práctica pesquera, los habitantes se organizan para defender su acceso al territorio y, en un sentido más amplio, sus formas de vida y de trabajo. Este caso, en particular, visibiliza maneras contemporáneas por las que el Estado despoja el territorio y desaparece prácticas culturales propias de los pueblos

  5. La Antigüedad Tardía en el Territorio de la Cathaginiensis Tierra de Cuenca

    OpenAIRE

    Dimas Benedicto, Carmen María

    2016-01-01

    La Tesis parte de una visión general que contextualiza la época de la Antigüedad Tardía, para ir descendiendo hacia lo particular en la provincia de Cuenca. Los objetivos que nos planteamos en primer lugar fueron los de analizar, a partit de las fuentes literarias, el proceso histórico de la Antigüedad tardía en el territorio de la Carthaginiensis . enmarcado en el tránsito de Hispania desde Roma al dominio islámico. En segundo lugar, el realizar una aproximación al impacto que para el te...

  6. La educación ambiental y su importancia en la relación sustentable: Hombre-Naturaleza- Territorio

    OpenAIRE

    Ronald Fernando Quintana Arias

    2017-01-01

    Objetivo. Promover la importancia de la educación ambiental en el fortalecimiento de la relación sustentable Hombre-Naturaleza-Territorio en 8 niños y niñas observadores de aves de la primaria María Berchmans. Metodología. Entre agosto y noviembre del 2015 desarrollé un estudio de caso basado en el aprendizaje vivencial, social y experiencial, que se dividió en dos fases en las que se encontraban 19 actividades clasificadas dentro de siete...

  7. Indigenismo y romanización del territorio abulense (s. V a.C.-s. III d.C.)

    OpenAIRE

    Hernando Sobrino, María Rosario

    1994-01-01

    Entendiendo por romanización el proceso de transformación de las estructuras que provoco la conquista romana en las estructuras de base indígena, sin suponer que tal transformación implique, necesariamente, la idea de semejanza a lo romano, se estudia la magnitud que dichos cambios alcanzaron en el territorio de la actual provincia de Ávila. En la 1 parte se presentan cuantas fuentes se han correlacionado para la elaboración de esta tesis (datos geográficos, arqueológicos, numismáticos, epigr...

  8. Agricultura, invención de un territorio y conservación “etnosférica”

    OpenAIRE

    Fabio Aldemar Gómez Sierra

    2010-01-01

    Este escrito deriva de un proceso de investigación acerca de los cambios de las sociedades campesinas boyacenses, es un estudio de caso relacionado con la incorporación de la vitivinicultura en las tradiciones agrícolas regionales. La movilidad del concepto territorio entendido como clima, suelo-subsuelo y cultura, fortalecido por la información y la globalización, es comparable con el término etnósfera o sistema de patrimonios comunitarios campesinos que exigen reconocimiento y protección. L...

  9. Valorización de la naturaleza y disputa por el territorio en la Provincia de Santa Cruz

    OpenAIRE

    Godoy, Pablo; Fasioli, Enzo; Valiente, Silvia; Schweitzer, Alejandro

    2013-01-01

    Desde los inicios de la colonización europea, la historia de la Patagonia es la trayectoria de la ocupación para la puesta en valor de la riqueza de sus bienes naturales en el suelo, subsuelo y en su extenso litoral marítimo. Asentados primero en la explotación del ovino, luego del petróleo, el gas y el carbón y recientemente de la pesca, la minería metalífera y el turismo internacional, los territorios de las actuales provincias de Santa Cruz, del Chubut y de Tierra del Fuego, al igual que s...

  10. El espacio público como territorio sexuado: el caso del Acoso Callejero desde un Enfoque de Género

    OpenAIRE

    María Soledad Martín de la Maza

    2014-01-01

    El presente artículo indaga en el fenómeno del Acoso Callejero como una problemática que puede ser analizada desde varias aristas: el espacio público, el territorio y la corporeidad. Para ello, se utilizará el Enfoque de Género, con el fin de tener una visión crítica y compleja de esta mala práctica que afecta la cotidianidad de las mujeres. Abstract This article investigates the phenomenon of public harassment that can be approached from multiple perspectives: public spaces, terri...

  11. Experimentaciones estéticas en el territorio periférico de Buenos Aires: la mirada de Ariel Magnus

    OpenAIRE

    Lima, Renata Dorneles

    2016-01-01

    IX Congresso Brasileiro de Hispanistas realizado nos dias 22 a 25 agosto 2016 Este trabajo, que trata de la fragmentación narrativa y experimentaciones estéticas en la novela La 31 (una novela precaria), de Ariel Magnus, se orienta en el sentido de pensar de qué forma las posibilidades encontradas por el autor para representar un territorio periférico y sus sujetos problematizan determinadas fronteras establecidas en el campo literario y nos hacen cuestionar la propia noción de...

  12. TERRITORIO Y PSICOLOGÍA SOCIAL Y COMUNITARIA, TRAYECTORIAS/IMPLICACIONES POLÍTICAS Y EPISTEMOLÓGICAS

    OpenAIRE

    Conti,Santiago

    2016-01-01

    RESUMEN "Territorio" es un concepto originado en el campo disciplinar de la Geografía, que a lo largo del siglo XX ha ido reformulándose según las distintas corrientes del pensamiento social. Es factible reconocer que en la actualidad dicho concepto ha trascendido su ámbito disciplinar y es utilizado profusamente en el campo de las ciencias sociales, en general, y en la Psicología Social y Comunitaria, en particular. Trascendiendo el encuadre disciplinar de la geografía, el presente trabajo s...

  13. Ordenación del territorio. Planificación ambiental y urbanismo bioclimático

    OpenAIRE

    Higueras García, Esther

    2013-01-01

    Ordenación del territorio, Planificación ambiental y urbanismo bioclimático .- La planificación ambiental .- El urbanismo bioclimatico 1. .- Metodología del Urbanismo Bioclimático. 2. .- Criterios bioclimáticos para el planeamiento general para la red viaria 3. .- Jerarquización de las vías urbanas 4. .- Consecuencias de la orientación de las calles sobre las parcelas y edificaciones. 5. - Estrategias bioclimáticas para el sistema general de zonas verdes y espacios libr...

  14. Desafíos del desarrollo rural en Argentina: una lectura desde un territorio de la pampa húmeda

    OpenAIRE

    Silvia Gorenstein; Martín Napal; Andrea Barbero

    2009-01-01

    En este artículo se ofrece una reflexión crítica acerca de las visionesque moldean las acciones públicas en apoyo a los pequeños y media-nos productores agrorrurales, y al desarrollo o sostenimiento de supoblación. Se parte del reconocimiento de los límites estructurales deestos territorios y se discuten las políticas vigentes; particularmente lapropuesta de nuevos lineamientos encuadrada en el enfoque del De-sarrollo Territorial Rural. Se propone una lectura analítica para plan-tear una seri...

  15. Aguas labradas: Regeneración de territorios fragmentados por la introducción de planos de agua artificial

    OpenAIRE

    Cumbre, Jose María

    2014-01-01

    [ESP] Los grandes complejos hidráulicos, caracterizados por su carácter duradero, transgeneracional y artificial, ocasionan graves problemas. Al no favorecer una integración con el continuo territorial, originan una vertiginosa merma de las economías locales y a la ruptura de vínculos entre las poblaciones y sus territorios. El entorno territorial de Alqueva se caracteriza por una población con un alto grado de envejecimiento y en progresivo proceso de recesión demográfica. Se trata asi...

  16. Direct regulation of IL-2 by curcumin.

    Science.gov (United States)

    Oh, Jin-Gyo; Hwang, Da-Jeong; Heo, Tae-Hwe

    2018-01-01

    Interleukin-2 (IL-2) is a crucial growth factor for both regulatory and effector T cells. Thus, IL-2 plays a critical role in the stimulation and suppression of immune responses. Recently, anti-IL-2 antibodies (Abs) have been shown to possess strong IL-2 modulatory activities by affecting the interaction between IL-2 and IL-2 receptors. In this study, we screened an herbal library to identify a compound that regulates IL-2, which resulted in the identification of curcumin as a direct binder and inhibitor of IL-2. Curcumin is a phytochemical with well-known anti-cancer properties. In this study, curcumin mimicked or altered the binding pattern of anti-IL-2 Abs against IL-2 and remarkably inhibited the interaction of recombinant IL-2 with the IL-2 receptor α, CD25. Interestingly, curcumin neutralized the biological activities of IL-2 both in vitro and in vivo. In this report, we elucidated the unsolved mechanism of the anti-cancer effect of curcumin by identifying IL-2 as a direct molecular target. Curcumin, as a small molecule IL-2 modulator, has the potential to be used to treat IL-2 related pathologic conditions. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Il libro agente della socializzazione

    Directory of Open Access Journals (Sweden)

    Daniela Sideri

    2017-06-01

    Full Text Available Il saggio indaga il ruolo del libro come agente di socializzazione, con particolare riferimento al pubblico dei lettori ragazzi e bambini e alle specifiche funzioni formative della “lettura della letteratura” in età pre-scolare e scolare fino ai 14 anni. La ricerca di matrice socio-culturale si è occupata per lo più del libro in qualità di prodotto eminentemente sociale (sociologia della letteratura, contenitore di testi significanti (semiotica, e bene di consumo dell’industria culturale (cultural studies: lo studio proposto richiama le conclusioni fondamentali di decenni di studi intorno al libro, con l’intento di rintracciare i criteri adeguati (tema, target, identità visiva, funzione pratica e utopica a guidare una classificazione dei generi 0-14 che evidenzi il valore socializzante di ciascuno, proponendo così una originale tipologia, che giustifica l’inserimento del libro tra quelle definite “agenzie testuali” della socializzazione.

  18. Il potere di Prometeo e il dovere di Kant

    Directory of Open Access Journals (Sweden)

    Stefano Picchetti

    2006-10-01

    Full Text Available Kant ci suggerisce qualcosa che Prometeo e il mito greco avevano già accennato. L'imperativo che pone freno al fare, è già in sé nel soggetto ed è per questo che egli che egli è responsabile delle proprie azioni, indipendentemente dalla legge scritta.

  19. Il Sole, il genoma e Internet strumenti delle revoluzioni scientifiche

    CERN Document Server

    Dyson, Freeman J

    2000-01-01

    In queste appassionate conferenze «di soglia» Dyson si sporge sul domani con la visionarietà di un Verne o di un Wells, consapevole però di abbozzare «solo uno dei corsi possibili, tra i milioni di altri che il futuro potrà riservarci». Il nuovo trivio di forze rivoluzionarie che, secondo il modello di Dyson, muoverà lo sviluppo ha nomi noti a tutti, e disputati da molti: energia solare, ingegneria genetica, rete di comunicazione globale. Un loro utilizzo flessibile e sinergico arriverebbe a ridisegnare il paesaggio sociale del pianeta, facendo affluire verso aree depresse risorse ora concentrate in pochi paesi, e ridando vita ovunque all'economia di villaggio. La raccolta di energia da una fonte equidistribuita come la luce solare potrebbe infatti avvenire attraverso coltivazioni arboree manipolate genetica mente allo scopo, con costi sostenibili e senza pregiudizio della ecodiversità. Sia che guardi al prossimo futuro terrestre sia che contempli la prospettiva non troppo lontana di insediamenti uma...

  20. Il programma dell'universo

    CERN Document Server

    Lloyd, Seth

    2006-01-01

    Da quando l'universo ha avuto inizio, ha cominciato a calcolare il proprio comportamento. All'inizio il computer-universo produceva strutture semplici, particelle elementari e leggi elementari della fisica; col passare del tempo ha processato "informazioni" sempre più complesse, producendo strutture sempre più intricate (galassie, stelle, pianeti), ma sempre secondo leggi semplici. Ogni cosa deve quindi la propria esistenza alla capacità intrinseca della materia e dell'energia di processare informazione. Se si decifrasse fino in fondo si potrebbe, con un computer quantistico di dimensioni ridotte, comprendere l'universo nel suo insieme.

  1. Ri-Costruiamo il futuro

    Directory of Open Access Journals (Sweden)

    Guido Maria Amorati

    2012-12-01

    Full Text Available Viene di seguito presentato un report della conferenza “Ri-Costruiamo il futuro” che si è tenuta il 3 ottobre 2012 presso la Facoltà di Ingegneria dell’Università di Bologna. L’evento è stato organizzato e promosso da Edarchibo, la rivista on line dela corso di Laurea in Ingegneria edile-architettura. Alcuni docenti hanno risposto alle domande degli studenti circa le possibilità professionali post-laurea e la ricostruzione a seguito del terremoto.

  2. Il Dio dell'Eriugena

    Directory of Open Access Journals (Sweden)

    Silvia Magnavacca

    2008-07-01

    Full Text Available In un universo interpretato come sogno da decifrare, la metafisica è lo strumento, secondo Borges, con cui l’uomo tenta di rendere coerente questo sogno. Il pensiero di Eriugena è particolarmente affascinante per Borges, in quanto accetta la sfida della veritigine: un Dio che dal nulla della sua indeterminatezza dà luogo al mondo, dispiegandosi negli archetipi che popolano il sogno dell’universo. Una fantastica metafisica che allontana dall’uomo lo sgomento per la condanna alla propria individualità.

  3. LA VALORIZZAZIONE DELLE PRODUZIONI TIPICHE VITIVINICOLE NEL TERRITORIO NAZIONALE, UN PROGETTO PILOTA NELLA PROVINCIA DI BERGAMO

    OpenAIRE

    Aldighieri, Barbara; Chiesa, Sergio; Deligios, Marco

    2009-01-01

    Le caratteristiche di un vino dipendono dalla cantina, dai vitigni utilizzati per la produzione delle uve, e dal terroir: quella combinazione magica di geologia, morfologia, clima, coltura e cultura che caratterizza l’ambiente dove il vino nasce. Un sistema informativo geografi co è uno strumento potentissimo al servizio della qualificazione del terroir perché aiuta gli esperti nell’elaborazione dei dati e nella loro analisi. La tecnologia WebGIS si rivela essere un valido strumen...

  4. El Neolítico antiguo en Aragón: Habitat y territorio

    Directory of Open Access Journals (Sweden)

    José María RODANÉS VICENTE

    2009-12-01

    Full Text Available RESUMEN: Las recientes excavaciones en yacimientos neolíticos aragoneses han permitido realizar estudios exhaustivos sobre diferentes aspectos de su cultura material. Los ensayos sobre industria lítica, cerámica, objetos de hueso y adorno, junto a las dataciones absolutas, muestran las afinidades de estas comarcas con el proceso de neolitización del Mediterráneo occidental. En este trabajo abordamos el análisis de hábitats y territorios de explotación, al mismo tiempo que intentamos definir las bases económicas, la funcionalidad y la posible relación entre los yacimientos catalogados. Los resultados completan e incrementan notablemente el volumen de información disponible, ayudando a comprender mejor el proceso de transición Epipaleolítico/Neolítico, la posterior adopción de nuevas formas de subsistencia y su posible incidencia en las relaciones sociales. Por último proponemos una nueva periodización, alejada de las manejadas hasta ahora, a la vez que intentamos explicar el origen y evolución del Neolítico aragonés recurriendo a modelos que reflejan con mayor claridad la complejidad del fenómeno.ABSTRACT: Recent excavations in neolithic aragonese sites have allowed to undertaken exhaustive studies on varions aspects of their material culture. Diverse ensays on lithic industry, ceramics, bone and adorn crafts, as well as radiocarbon data shows the affinities of these áreas with the neolitization in Western Mediterranean. This paper focuses on habitat and site territory, and tries also to define the economíc structure, functionality, and possible link among the site considered. The results complete and increase considerably the amount of information avalaible, contributing to a better understanding of the Epipalaeolithic/Neolithic transition, the ulterior adquisition of new forms of subsistence and their possible effect on the level of social behaviour. Lastly, a new periodization, different from the up-to-date usual ones

  5. Configuración de territorios de violencia y control policial: corporalidades, emociones y relaciones sociales

    Directory of Open Access Journals (Sweden)

    Deborah Daich

    2007-07-01

    Full Text Available Este trabajo se centra en el análisis de los procesos de configuración de territorios de violencia y control policial resultantes de la malla de relaciones y prácticas sociales que vinculan a grupos policiales con sujetos y colectivos que habitualmente son definidos y tipificados por la misma agencia policial como objeto de su control y administración. Se enfatiza, para ello, en el análisis de las corporalidades y emociones qua constructoras de cuerpos, identidades y relaciones sociales. Esto, pues entendemos que son las redes de sociabilidad que vinculan recíprocamente a los individuos mediante interdependencias de diversa clase, las que configuran el campo de lo cotidiano sobre el que se construyen y producen las formas efectivas de control y violencia.Este trabalho centra-se na análise dos processos de configuração de territórios de violência e controle que resultam da malha de relações e práticas sociais que vinculam grupos policiais com sujeitos e coletivos aos quais a mesma instituição policial define e tipifica como seu objeto de controle y administração. Da-se ênfase nas corporalidades e emoções qua construtoras de corpos, identidades e relações sociais. Isso assim, pois se entende que são as redes de sociabilidade, que vinculam reciprocamente aos indivíduos mediante interdependências de diverso tipo, as que configuram o campo do cotidiano sobre o qual se constroem e produzem formas efetivas de controle e violência.This work is centered in the analysis of the processes of configuration of violent territories and police control as resultants of the network of social relations and practices that bind police groups with subjects and groups, regularly defined and typified by the same police agency as objects of their control and administration. It is focused, in that sense, in the analysis of the corporalities and emotions qua constructors of bodies, identities and social relations. This, because we understand

  6. Santiago: territorios, anhelos y temores. Efectos sociales y espaciales de la expansión urbana

    Directory of Open Access Journals (Sweden)

    María Elena Ducci

    2000-12-01

    Full Text Available El artículo se propone examinar cuáles son los tipos de espacios que se generan en la ciudad de Santiago de Chile, centrando su interés en aquellas áreas que se despliegan en los límites de la urbe. La periferia se ha ido desarrollando a través de la fuerte expansión experimentada por la ciudad durante las últimas décadas, surgiendo en ella nuevos desarrollos que comienzan a modificar la forma de habitar el territorio. Entre estos identificar zonas residenciales de nivel medio y alto, áreas de vivienda social, "artefactos de la globalización" y nuevas zonas industriales. Dada la importancia de los cambios, se analiza cómo dicho crecimiento desigual, está afectando la vida de los habitantes urbanos y cómo resulta vivir en cada uno de estos fragmentos yuxtapuestos. Adicionalmente se examinan las dinámicas que subyacen a las formas urbanas contemporáneas, las políticas de localización de las personas y actividades, el síndrome de la casa propia, el estatus y el estigma en la ciudad, la ciudad que decimos querer para vivir y el miedo a la violencia y al crimenThe article proposes to examine the types of space being generated in Santiago, Chile, focusing on those areas that spread out on the edges of the city. The periphery has been developing through the strong expansion experienced by the city during the last decades, and new developments are beginning to modify the way in which territory is ocuppied. Among these developments are residential areas of middle and upper social levels, areas of public housing, "artifacts of globalization" and new industrial areas. Given the importance of these changes, the paper analyzes how this unequal growth is affecting the life of city-dwellers and what it is like to live in each one of these juxtaposed fragments. Additionally, the dynamics that underlie contemporary urban forms, the politics of people’s location and activities, the syndrome of ownership , urban status and stigma, the city

  7. Contexto histórico de un territorio. El centro occidente colombiano antes de la colonización antioqueña

    Directory of Open Access Journals (Sweden)

    Sebastián Martínez Botero

    2011-05-01

    Full Text Available Partiendo de la idea de que los territorios son espacios sociales, y por ende históricos y cambiantes, este artículo pretende trazar los rasgos generales del territorio que se configuró entre la conquista hispánica y el proceso de re-poblamiento conocido como “colonización antioqueña” en el centro occidente de la actual República de Colombia. El enunciamiento de las principales características históricas del territorio estudiado, permitirán componer un contexto general del mismo que servirá de apoyo al estudio de esta región que, salvo pocos ejemplos, ha permanecido descuidada por los historiadores.

  8. Linkage and association studies of IL1B and IL1RN gene polymorphisms in preeclampsia

    NARCIS (Netherlands)

    Lachmeijer, AMA; Nosti-Escanilla, MP; Bastiaans, EB; Pals, G; Sankuijl, LA; Kostense, PJ; Aarnoudse, JG; Crusius, JBA; Pena, AS; Dekker, GA; Arngrimsson, R; ten Kate, LP

    2002-01-01

    Objective: To determine whether preeclampsia is either associated with or linked to two polymorphisms in the IL1B gene (IL1B-TaqI and IL1B-511) and one polymorphism in the IL1RN gene (IL1RN-IVS2). Methods: Genotyping was performed in 150 affected sib-pair families and 104 healthy Dutch blood donors.

  9. El efecto del territorio en la movilidad social de hogares de la Región Mentropolitana de Buenos Aires.

    Directory of Open Access Journals (Sweden)

    Paula Boniolo

    2017-01-01

    Full Text Available El presente estudio aborda los vínculos entre la socialización territorial y la movilidad social intergeneracional de hogares en la Región Metropolitana de Buenos Aires (RMBA. Para ello, se analiza en qué medida la socialización territorial condiciona las posibilidades de movilidad social ascendente. Los datos utilizados provienen de la base de datos de la encuesta de Estratificación y movilidad social en la Argentina (2007 del Centro de Estudios de Opinión Pública (CEDOP, Instituto de Investigaciones Gino Germani – Universidad de Buenos Aires. Los hallazgos principales del estudio se centran en que las características de la socialización en las zonas de residencia juvenil, donde se construyen vínculos y configuran expectativas, favorecen o refuerzan patrones de movilidad según la herencia de clase. Asimismo, otra pauta que el estudio muestra es que si bien la educación sigue atada a los orígenes sociales y ligada al territorio, ejerce un efecto en las posibilidades y oportunidades en el camino de ascenso social. El presente estudio brinda elementos para sustentar la hipótesis de que el territorio tiene un peso específico propio en los procesos de estratificación social.

  10. USO DEL SUELO E IMPUESTO SOBRE EL TERRITORIO URBANO EN EL CONTEXTO JURÍDICO DE AMÉRICA LATINA

    Directory of Open Access Journals (Sweden)

    Fagner Dantas

    2014-01-01

    Full Text Available Este texto reúne consideraciones acerca de la regulación del uso del suelo y del impuesto sobre el territorio, entendido como un fundamento del Derecho Urbanístico, dentro del ordenamiento jurídico de un grupo de países latino-americanos, Fueron estudiadas las constituciones de diferentes países y, por tanto, diferentes contextos socio-jurídicos, de América Latina, de modo de comparar el la manera del accionar en el territorial estatal. El estudio abarco seis subtemas: alcance, alternativas, instrumentos, intervención sobre el mercado del suelo, planes e impuesto sobre la propiedad inmobiliaria. Las conclusiones apuntan en el sentido de identificar algunas diferencias en los diversos ordenamientos jurídicos. Sin embargo no queda duda de que, en el contexto contemporáneo, las relaciones entre Estado y Territorio están delante de un nuevo nivel interpretativo.

  11. Canal Segarra-Garrigues: Transformación de un territorio, transformación de las personas

    Directory of Open Access Journals (Sweden)

    Javier del Estal Malillos

    2015-01-01

    Full Text Available El regadío del Sistema Segarra-Garrigues transformará una superficie de más de 95.000 Ha de secano en regadío.Siempre nos fijamos en los números macros de una actuación como esta: inversión, incremento de producción, hm3 de agua consumida, municipios afectados, propietarios beneficiados, etc. Pero no reparamos en la visión de las personas que se ven envueltas, de una forma u otra, por el cambio que supone la llegada del agua de riego. A través de exponer una serie de experiencias personales pretendo aportar datos que ayuden a quien desee analizar el nuevo regadío del Segarra-Garrigues desde una perspectiva menos técnica o económica y más social o antropológica. El cambio que perciben las personas del territorio es muy importante en muchos aspectos. Aporto las experiencias propias que en ocho años de contacto con las personas del territorio he considerado más significativas, y que proporcionan una óptica y una interpretación  diferente de la que utilizamos habitualmente los ingenieros.

  12. Concentración y uso corporativo del territorio en Argentina: la lógica territorial de Carrefour

    Directory of Open Access Journals (Sweden)

    Josefina Di Nucci

    2015-01-01

    Full Text Available Se propone en este trabajo estudiar las empresas comerciales en cadenas que, por su elevado gra-do de tecnología, organización y concentración del capital, usan de manera diferencial y jerárqui-ca el territorio. Los supermercados en Argentina poseen un mercado cada vez más concentrado y oligopolizado resultado del proceso de fusiones y adquisiciones en ese sector y otros afines. Se analiza la lógica de Carrefour durante la última década y su accionar en la provincia de Buenos Aires y la Ciudad Autónoma de Buenos Aires. Se cuenta con una base de datos propia compuesta por la cantidad de establecimientos y su localización espacial. Estos datos han sido extraídos de la página oficial de dicha compañía. Se observa que esta empresa acrecentó su participación en el mercado a través de la difusión de sus establecimientos por el territorio, fundamentalmente con la apertura de tiendas de cercanía o proximidad y la incorporación de un alto porcentaje de productos de marcas propias.

  13. Cartografía semiótica para la comprensión de territorios de conflicto

    Directory of Open Access Journals (Sweden)

    Béatriz Nates Cruz

    2006-01-01

    Full Text Available Este artículo aborda el tema del desplazamiento forzado desde los siguientes ejes de investigación: la apropiación material y simbólica del espacio en el proceso de construcción del territorio y la configuración de los espacios de conflicto; y las construcciones simbólicas y sociales adoptadas por los desplazados como actores sociales individuales y colectivos. Además, pone a consideración un ejercicio metodológico a través de un análisis antropológico y geográfico sobre la morfología y configuración sociopolítica y económica de los territorios urbanos y rurales del departamento de Caldas desde el año 2000. El análisis está basado en la elaboración de una cartografía semiótica con énfasis en la grafía de las representaciones, y presenta dos categorías de mapas: los temáticos y los sintéticos.

  14. Confrontación, territorio y "espiritualidad". El lugar de los rituales mapuche en el proceso del poder.

    Directory of Open Access Journals (Sweden)

    Hernán Horacio Schiaffini

    2015-12-01

    Full Text Available Indagamos en torno a la organización y el desarrollo de rituales mapuche en el noroeste de Chubut y sudoeste de Río Negro, situando el desarrollo de estas ceremonias en el marco de las luchas por el territorio que atraviesan las familias, las comunidades y las organizaciones de la zona, así como las alianzas políticas y sociales que elaboran. Sostenemos que, en la actualidad, jerarquizar analíticamente la esfera de las confrontaciones permite observar cómo el ritual y el territorio se articulan a través de la construcción de fuerzas sociales. Ponemos especial énfasis en demostrar la vigencia y eficacia de las celebraciones rituales, sin que este carácter “instrumental” niegue sus contenidos mitológicos y filosóficos en constante renovación. Para ello damos cuenta de su organización y sentidos, revisamos la historia de los grupos mapuche en Argentina y describimos y analizamos algunos casos etnográficos, basándonos en el trabajo de campo realizado en la región desde 2009.

  15. El mito de pristinidad y los usos efectivos del territorio de la región de Magallanes, Patagonia Chilena: Forestal, minería y acuicultura

    OpenAIRE

    Inostroza, Luis

    2015-01-01

    Los métodos de clasificación de usos del suelo en regiones remotas presentan dos serias limitaciones. La primera es la mixtura conceptual de usos con coberturas que no refleja el uso efectivo del territorio. Una segunda limitación es la ausencia de usos importantes como turismo, acuicultura y minería, que imponen importantes presiones sobre territorios frágiles. Este trabajo presenta un método para determinar los usos territoriales en la región de Magallanes en el extremo austral de Chile. Se...

  16. Role of IL-38 and Its Related Cytokines in Inflammation

    Directory of Open Access Journals (Sweden)

    Xianli Yuan

    2015-01-01

    Full Text Available Interleukin- (IL- 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.

  17. Clinical significance of measurement of changes of serum IL-6, IL-18 and IL-1β levels after treatment in patients with endometriosis

    International Nuclear Information System (INIS)

    Zhang Chunyan; Zhang Shumin; Zhou Dongxia; Wang Enbo

    2008-01-01

    Objective: To explore the clinical significance of changes of serum IL-6, IL-18 and IL-1β levels after treatment in patients with endometriosis. Methods: Serum IL-6 (with RIA) and IL-18, IL-1β (with ELISA) levels were determined in 38 patients with endometriosis both before and after treatment as well as 35 controls. Results: Before treatment, the serum IL-6, IL- 18 and IL-1β levels were significantly higher in the patients than those in controls (P 0.05). Conclusion: Detection of serum IL-6, IL-18 and IL- 1β levels might reflect the progress of diseases in patients with endometriosis. (authors)

  18. IL-6 Receptor Isoforms and Ovarian Cancer

    Science.gov (United States)

    2013-01-01

    2 mice were normal in appearance and were born in the expected Mendelian ratio. Il6ra2/2 mice have a defective response to IL-6 IL-6 is critical for...improved wound contraction in Il62/2 mice (Fig. 5F, 5G), similar to data obtained in mice with a combined genetic deficit of IL-6 and IL-6Ra. These data...specificity from the cytokine receptor gp130. Trends Genet . 20: 23–32. The Journal of Immunology 7227 at U niv of C incinnati Serials R eceiving A cq D ept

  19. Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer

    Directory of Open Access Journals (Sweden)

    Bachmann Alexander

    2011-09-01

    Full Text Available Abstract Background Chronic inflammation has been suggested to favour prostate cancer (PCA development. Interleukins (IL represent essential inflammation mediators. IL-2, IL-7, IL-15 and IL-21, sharing a common receptor γ chain (c-γ, control T lymphocyte homeostasis and proliferation and play major roles in regulating cancer-immune system interactions. We evaluated local IL-2, IL-7, IL-15 and IL-21 gene expression in prostate tissues from patients with early stage PCA or benign prostatic hyperplasia (BPH. As control, we used IL-6 gene, encoding an IL involved in PCA progression. IL-6, IL-7 and IL-15 titres were also measured in patients' sera. Methods Eighty patients with BPH and 79 with early (1 to 2c stage PCA were enrolled. Gene expression in prostate tissues was analyzed by quantitative real-time PCR (qRT-PCR. Serum IL concentrations and acute phase protein titres were evaluated by ELISA. Mann-Whitney, Wilcoxon and χ2 tests were used to compare IL gene expression and serum titers in the two groups of patients. Receiver operating characteristic (ROC curves were constructed to evaluate the possibility to distinguish sera from different groups of patients based on IL titers. Results IL-2 and IL-21 gene expression was comparably detectable, with low frequency and at low extents, in PCA and BPH tissues. In contrast, IL-6, IL-7 and IL-15 genes were expressed more frequently (p Conclusions Expression IL-7 and IL-15 genes in prostate tissues and corresponding serum titres are significantly increased in patients with early stage PCA as compared with patients with BPH.

  20. La huella en el territorio del sistema agroalimentario (1900-2015

    Directory of Open Access Journals (Sweden)

    Marian Simón Rojo

    2016-07-01

    Full Text Available En la actualidad, cuando crece el interés en relocalizar el sistema alimentario, conviene entender cómo funcionaba el territorio cuando ese sistema se basaba en una agricultura de proximidad. Conviene entender a su vez cómo y por qué se descompuso ese sistema, aprendiendo del pasado para avanzar hacia un urbanismo comprometido con la satisfacción de las necesidades humanas de alimentos de una manera más justa y más respetuosa con el planeta. El análisis histórico se centra en el tramo medio del valle del Duero. Los sistemas territoriales que se han sucedido desde principios del siglo XX responden a tres modelos del sistema agroalimentario, que se asocian con las distintas etapas nutricionales. Hay una correlación entre modelo nutricional de superación de la desnutrición, agricultura familiar, en la zona hasta 1950; modelo de consumo de masas y sobrealimentación, agricultura industrializada, que se extiende hasta 1985; y modelo de consumo segmentado, agricultura terciarizada, que dura hasta nuestros días. En esta última fase conviven dos tendencias: una hacia la jerarquización y el productivismo tecnificado y otra hacia la multifuncionalidad y la recampesinización que se reapropia de las innovaciones técnicas. El urbanismo cuenta con herramientas y mecanismos podrían aportar una dimensión espacial y funcional hasta ahora descuidada. Hay indicios que apuntan que el momento para reconsiderar los sistemas agroalimentarios también desde el urbanismo, favoreciendo su relocalización y una transición agroecológica, ha llegado. Abstract The historical review of the relationship between territory and agrifood system provides key lessons to help rebuild the territorial structure, seizing the opportunity offered by a renewed interest in local and sustainable food. The historical transdisciplinary research focuses on the middle reaches of the Douro valley (Castilla y Leon, Spain. After the analysis of the evolution of the region since

  1. Aloin Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.

    Science.gov (United States)

    Na, Hee Sam; Song, Yu Ri; Kim, Seyeon; Heo, Jun-Young; Chung, Hae-Young; Chung, Jin

    2016-06-01

    Interleukin (IL)-1β, which is elevated in oral diseases including gingivitis, stimulates epithelial cells to produce IL-8 and perpetuate inflammatory responses. This study investigates stimulatory effects of salivary IL-1β in IL-8 production and determines if aloin inhibits IL-1β-stimulated IL-8 production in epithelial cells. Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis. Saliva with high IL-1β strongly stimulated IL-8 production in KB cells, and IL-1 receptor agonist significantly inhibited IL-8 production. Low IL-1β-containing saliva did not increase IL-8 production. IL-1β treatment of KB cells induced activation of MAPK signaling molecules as well as nuclear factor-kappa B. IL-1β-induced IL-8 production was decreased by p38 and extracellular signal-regulated kinase (ERK) inhibitor treatment. Aloin pretreatment inhibited IL-1β-induced IL-8 production in a dose-dependent manner and inhibited activation of the p38 and ERK signaling pathway. Finally, aloin pretreatment also inhibited saliva-induced IL-8 production. Results indicated that IL-1β in saliva stimulates epithelial cells to produce IL-8 and that aloin effectively inhibits salivary IL-1β-induced IL-8 production by mitigating the p38 and ERK pathway. Therefore, aloin may be a good candidate for modulating oral inflammatory diseases.

  2. A Novel Immunoregulatory Function for IL-23: Inhibition of IL-12 Dependent IFN-γ Production

    Science.gov (United States)

    Sieve, Amy N.; Meeks, Karen D.; Lee, Suheung; Berg, Rance E.

    2011-01-01

    Summary Most studies investigating the function of IL-23 have concluded that it promotes IL-17 secreting T cells. While some reports have also characterized IL-23 as having redundant pro-inflammatory effects with IL-12, we have instead found that IL-23 antagonizes IL-12 induced secretion of IFN-γ. When splenocytes or purified populations of T cells are cultured with IL-23, IFN-γ secretion in response to IL-12 is dramatically reduced. The impact of IL-23 is most prominent in CD8 T cells, but is also observed in NK and CD4 T cells. Mechanistically, the IL-23 receptor is not required for this phenomenon, and IL-23 inhibits signaling through the IL-12 receptor by reducing IL-12 induced signal transducer and activator of transcription 4 (STAT4) phosphorylation. IL-23 is also able to reduce IFN-γ secretion by antagonizing endogenously produced IL-12 from Listeria monocytogenes (LM) infected macrophages. In vivo, LM infection induces higher serum IFN-γ levels and a greater percentage of IFN-γ+CD8+ T cells in IL-23p19 deficient mice as compared to wild-type mice. This increase in IFN-γ production coincides with increased LM clearance at days 2–3 post-infection. Our data suggest that IL-23 may be a key factor in determining the responsiveness of lymphocytes to IL-12 and their subsequent secretion of IFN-γ. PMID:20458705

  3. Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα Antagonist to Inhibit IL-4 Signalling

    Directory of Open Access Journals (Sweden)

    Nayyar Ahmed

    2015-05-01

    Full Text Available Background/Aims: In recent times, allergy has become a financial, physical and psychological burden to the society as a whole. In allergic cascades, cytokine IL-4 binds to IL-4 receptor (IL-4R, consequently producing allergen-specific IgE antibodies by B cells. In addition, among other functions, IL-4 is also responsible for B and T cell proliferation and differentiation. Hence, characterization of novel antagonists that inhibit IL-4 signalling forms the overall aim of this study. Methods: Phage display was used to screen a random 12-mer synthetic peptide library with a human IL-4Rα to identify peptide candidates. Once identified, the peptides were commercially synthesized and used for in vitro immunoassays. Results: We have successfully used phage display to identify M13 phage clones that demonstrated specific binding to IL-4Rα. The peptide N1 was synthesized for use in ELISA, demonstrating significant binding to IL-4Rα and inhibiting interaction with cytokine IL-4. Furthermore, the peptide was tested in a transfected HEK-Blue IL-4 reporter cell line model, which produces alkaline phosphatase (AP. QUANTI-Blue, a substrate, breaks down in the presence of AP producing a blue coloration. Using this colorimetric analysis, >50% inhibition of IL-4 signalling was achieved. Conclusion: We have successfully identified and characterised a synthetic peptide antagonist against IL-4Rα, which effectively inhibits IL-4 interaction with the IL-4Rα in vitro. Since IL-4 interaction with IL-4Rα is a common pathway for many allergies, a prophylactic treatment can be devised by inhibiting this interaction for future treatment of allergies.

  4. The role of IL-17 in psoriasis.

    Science.gov (United States)

    Malakouti, Mona; Brown, Gabrielle Elena; Wang, Eva; Koo, John; Levin, Ethan C

    2015-02-01

    Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to review the basic science data relevant to IL-17's role in psoriasis pathogenesis. We performed a Pubmed and Web of Knowledge search for English articles starting from 1990 that discussed the Th17 pathway. Search terms such as "IL-17" and "psoriasis" were utilized. The IL-17 pathway is regulated by IL-23, a cytokine that is vital for the expansion and maintenance of the Th17 cell population. Th17 derived cytokines (IL-17A, IL-17F, IL-17A/F and IL-22) were elevated in both psoriasis-like murine models and human psoriatic lesional biopsies. Ixekizumab (anti-IL-17A) treatment of psoriasis was found to normalize levels of IL-17 downstream gene products. Both preclinical and clinical studies support the central role of IL-17 in the pathogenesis of psoriasis.

  5. WiFiabe: un’esperienza di storytelling dal territorio al web 2.0

    Directory of Open Access Journals (Sweden)

    Marco Carnesecchi

    2013-03-01

    Full Text Available L’impatto iniziale di WiRoni sulla popolazione di Monteroni d’Arbia (Siena è stato limitato alla fruizione dei contenuti caricati dal team di design, in particolare le storie per i bambini. Mancavano infatti brani audio prodotti dalla comunità locale. In realtà, però, la competenza tecnica necessaria a trasmettere i contenuti nel parco e in rete è minima (upload da CMS wordpress e anche le tecnologie per registrare e arricchire l’audio con effetti sonori sono alla portata di tutti, se opportunamente guidati da esperti. Da queste osservazioni è nato il progetto WiFiabe. Nel corso dell’anno scolastico 2010/2011 20 bambini tra 6 e 13 anni, coordinati da un’educatrice durante l’attività di doposcuola del Comune, hanno lavorato in gruppi e creato storie di fantasia. In seguito, alcuni studenti dell’Università di Siena, con l’aiuto di un musicista per la parte degli effetti sonori, hanno assistito i ragazzi nel diventare autori digitali e apprendere in prima persona come trasformare le loro storie in contenuti audio. In questo modo i partecipanti hanno interagito con il web non in quanto fruitori ma come autori, e messo in moto un processo per rendere WiRoni uno strumento per dare voce alle varie anime della comunità.

  6. Hmgb1-IL-23-IL-17-IL-6-Stat3 Axis Promotes Tumor Growth in Murine Models of Melanoma

    Directory of Open Access Journals (Sweden)

    Qiu Tang

    2013-01-01

    Full Text Available In order to understand how tumor cells can escape immune surveillance mechanisms and thus develop antitumor therapies, it is critically important to investigate the mechanisms by which the immune system interacts with the tumor microenvironment. In our current study, IL-17 deficiency results in reduced melanoma tumor size, diminished numbers of proliferating cells and blood vessels, and decreased percentage of CD11b+Gr-1+ MDSCs in tumor tissues. IL-17 promotes IL-6 induction and Stat3 activation. Treatment of Stat3 inhibitor WP1066 in B16-F10 tumor cells inoculated wild-type mice inhibits tumor growth. Additional administration of recombinant IL-6 into B16-F10 tumor-bearing IL-17−/− mice results in markedly increased tumor size and p-Stat3 expression, whereas additional recombinant IL-17 administration into B16-F10 tumor-bearing wild-type mice treated with anti-IL-6 mAb does not significantly alter the tumor growth and p-Stat3 expression. In our further study, blockade of Hmgb1-RAGE pathway inhibits melanoma tumor growth and reduces production of IL-23 and IL-17. All these data suggest that Hmgb1-IL-23-IL-17-IL-6-Stat3 axis plays a pivotal role in tumor development in murine models of melanoma, and blocking any portion of this axis will attenuate melanoma tumor growth.

  7. Marco jurídico que controla el tráfico ilícito de migrantes y la trata de personas en Nicaragua. Estudio de caso: Puesto Fronterizo Peñas Blancas

    OpenAIRE

    Heydi José González Briones

    2007-01-01

    EN ESTE ARTÍCULO SE EXPONE UN ANÁLISIS DEL MARCO JURÍDICO – internacional y nacional – para combatir los delitos de tráfico ilícito de migrantes y trata de personas, que tienen lugar dentro del fenómeno de la migración irregular. Dicho análisis tiene como referencia las particularidades de la migración irregular dentro del territorio nicaragüense – como país emisor de migrantes y como zona de tránsito para migrantes extraregionales. En concreto, nos referimos a los flujos migratorios irregula...

  8. Fases y territorios de la neolitización del NE de la Península Ibérica ca. 5600-4900 cal BC

    Directory of Open Access Journals (Sweden)

    F. Xavier OMS-ARIAS

    2017-01-01

    Full Text Available En este trabajo se presentan los datos radiocarbónicos y de las cerámicas decoradas de numerosos yacimientos del NE Peninsular pertenecientes al Neolítico antiguo (c.5600-4900. Mediante el análisis de los dos registros, se han podido detectar características culturales independientes en diferentes territorios de esta región. Después de una primera ocupación de poca entidad, probablemente relacionada con el Neolítico Impressa, se pasa a una primera oleada de poblaciones cardiales. Éstas se distribuyen por diferentes ámbitos geográficos litorales y prelitorales y ya presentan diferencias en sus producciones cerámicas. Durante una fase evolucionada (a partir de c. 5300 cal BC, los territorios diversifican sus producciones cerámicas aún más en los territorios litorales y prelitorales. Sin embargo, las nuevas zonas ocupadas presentan registros donde se mezclan los componentes cardiales y los epicardiales, sobretodo en la región de Segre-Pirineos. Estos datos reflejan por un lado una rápida distribución por todo el territorio durante la neolitización, pero también un carácter particular entre diferentes comunidades neolíticas, lejos de una visión homogénea del proceso.

  9. LA PATAGONIA COMO TERRITORIO EN DISPUTA: TENSIONES ENTRE EL ESTADO, LA IGLESIA Y LA CONGREGACIÓN SALESIANA POR EL ESPACIO MISIONERO

    Directory of Open Access Journals (Sweden)

    María Nicoletti

    2012-06-01

    Full Text Available La Patagonia fue el primer territorio salesiano “ad gentes”. La creación de su administración bajo la figura de un Vicariato y Prefectura apostólica de parte de la Congregación Salesiana y el Colegio de Propaganda Fide, trajo aparejados numerosos conflictos con las Iglesias Argentina y Chilena y con ambos Estados nacionales. Estos conflictos, en el marco histórico de la construcción de las naciones del siglo XIX y principios del siglo XX, fueron acompañados por los planes de evangelización que la Congregación salesiana había formulado para los pueblos originarios. Bajo la gestión y dirección de los dos primeros rectores mayores de la Congregación, Don Bosco y Don Rua, se resolvieron los problemas con las Iglesias y Estados de ambas naciones, cargados de tensiones en la construcción del territorio de evangelización considerado según cada institución como “terra nullius”, “territorio salesiano” o “territorio nacional y diocesano”.

  10. Reflexiones identitarias en el territorio contemporáneo. La construcción colectiva de lugar. Caso de estudio de la Vega de Granada

    Directory of Open Access Journals (Sweden)

    María Teresa Zapiain Aizpuru

    2011-01-01

    Full Text Available El objetivo del artículo es participar en el debate actual sobre las nociones que nos conducen al mantenimiento y desarrollo de un territorio con identidad. Para alcanzar dicho objetivo, y considerando la distinción de significado establecida entre los conceptos de espacio, territorio y paisaje y su relación indisociable con la cultura y la identidad, en su primera parte, el artículo expone una propuesta teórica de interpretación de los procesos identitarios vinculados con el territorio como construcción social. En la segunda parte, se presenta algunos de los principales resultados sobre la investigación empírica desarrollada en la «Vega de Granada». En ésta se explora la influencia de ciertas transformaciones socioeconómicas y culturales en los procesos de identificación con el lugar. Se concluye enfatizando la importancia de este tipo de abordajes para el éxito de los planes de ordenación y desarrollo territorial, proponiendo el estudio no sólo de las dimensiones físicas o sectoriales de un territorio, sino su significado como lugar.

  11. Trabajo de campo en el territorio de San Juan Lachao, Oaxaca. Un acercamiento desde las “otras” geografías al paisaje chatino

    Directory of Open Access Journals (Sweden)

    Geronimo Barrera de la Torre

    2016-11-01

    Este trabajo se realizó en los territorios del municipio de San Juan Lachao, en el sur del estado de Oaxaca.1 Durante este tiempo se llevaron a cabo seis estancias que variaron en duración y objetivos.

  12. IL RADIODRAMMA COME STRUMENTO DIDATTICO

    Directory of Open Access Journals (Sweden)

    Valeria Cattaneo

    2018-03-01

    Full Text Available Può un format apparentemente superato come il radiodramma rappresentare uno strumento didattico innovativo? In questo articolo viene presentato un progetto sperimentale in cui il format del dramma radiofonico è stato messo al servizio dell’insegnamento dell’italiano come lingua seconda. Dopo una breve rassegna delle peculiarità di questo “teatro senza palcoscenico”, se ne illustrano sommariamente la storia e le precedenti applicazioni in ambito scolastico-formativo. In seguito sono esposte la struttura, le tempistiche e gli strumenti di realizzazione, nonché le finalità didattiche complessive e quelle peculiari di ciascuna fase del progetto. Vengono quindi esplicitate le funzioni comunicative, le aree lessicali e le strutture morfosintattiche selezionate per portare a termine il task finale: la produzione di una puntata di radiodramma. Nella conclusione, nell’ottica di una possibile riproposta del progetto, si mettono in luce i punti di forza e le criticità emerse dalla sperimentazione attuata. In Appendice viene dato il copione del radiodramma in versione integrale, accompagnato da un collegamento ipertestuale per poter ascoltare il podcast prodotto dagli studenti.   Radio drama as a teaching tool Can an apparently old-fashioned format like a radio play be an innovative teaching tool? This article illustrates an experimental project where this format was used to teach Italian as a second language. After a brief overview of the peculiarities of this “stageless theatre”, a summary of its history and applications in schools and training contexts is presented. The structure of the radio play, the time and realization of the tools is explained, with the general didactic goals and the specific purpose of each stage of the project. The communicative functions, the lexical areas and the morpho-syntactic structures selected in order to create the final project – the production of a radio play – are summarized. In conclusion, we

  13. Screening criteria for ILs used in NH

    NARCIS (Netherlands)

    Wang, M.; Infante Ferreira, C.A.; Groll, Eckhard

    2016-01-01

    This paper describes a properties-optimization work for the working fluids in NH3 / ionic liquid (ILs) based single-effect absorption heat pumps. The optimum parameters of the IL can be used as criteria in screening task-specified ILs, which play the role of absorbents, in absorption heat pumps.

  14. Il Generale e il professore. Roma-Lubiana 1942

    OpenAIRE

    Sala, Teodoro

    2004-01-01

    Durante l'estate del 1942 l'XI Corpo d'armata scatenò la sua offensiva mettendo a ferro e fuoco la Slovenia annessa. Fungeva da vademecum la circolare di Roatta: esecuzioni sommarie anche collettive, incendio di centri abitati, deportazione di nuclei sempre più consistenti di civili, distruzione di opere pubbliche, requisizioni di bestiame e derrate, furono all'ordine del giorno. Impegnati nelle operazioni sessantamila soldati di quattro divisioni più complementi. Il comandante del Corpo d'ar...

  15. Cord Blood Cells Responses to IL2, IL7 and IL15 Cytokines for mTOR Expression

    Directory of Open Access Journals (Sweden)

    Anahita Mohammadian

    2017-04-01

    Full Text Available Purpose: Mammalian target of rapamycin (mTORis important in hematopoiesis and affect cell growth,differentiation and survival. Although previous studies were identified the effect of cytokines on the mononuclear cells development however the cytokines effect on mTOR in cord blood mononuclear cells was unclear. The aim of this study was to evaluate mTOR expression in cord blood mononuclear and cord blood stem cells (CD34+ cells in culture conditions for lymphoid cell development. Methods: Isolation of The mononuclear cells (MNCs from umbilical cord blood were done with use of Ficollpaque density gradient. We evaluated cultured cord blood mononuclear and CD34+ cells in presece of IL2, IL7 and IL15 at distinct time points during 21 days by using flow cytometry. In this study, we presented the role of IL2, IL7 and IL15 on the expression of mTOR in cord blood cells. Results: mTOR expression were increased in peresence of IL2, IL7 and IL15 in day 14 and afterword reduced. However in persence of IL2 and IL15 expression of mTOR significantly reduced. mTOR expression in CD34+ cells decreased significantly from day7 to day 21 in culture. Conclusion: cytokines play important role in mTOR expression during hematopoiesis and development of cord blood mononuclear cells.

  16. El espacio público como territorio sexuado: el caso del Acoso Callejero desde un Enfoque de Género

    Directory of Open Access Journals (Sweden)

    María Soledad Martín de la Maza

    2014-07-01

    Full Text Available El presente artículo indaga en el fenómeno del Acoso Callejero como una problemática que puede ser analizada desde varias aristas: el espacio público, el territorio y la corporeidad. Para ello, se utilizará el Enfoque de Género, con el fin de tener una visión crítica y compleja de esta mala práctica que afecta la cotidianidad de las mujeres. Abstract This article investigates the phenomenon of public harassment that can be approached from multiple perspectives: public spaces, territory and corporality. The article aproaches the issue from a Gender Perspective, in order to develop a critical and complex view on this cultural phenomenon that adversely affects everyday women.

  17. El mapa no es el territorio: un ensayo sobre el estado de la economía

    Directory of Open Access Journals (Sweden)

    John Kay

    2014-06-01

    Full Text Available Gran parte de la economía moderna, incluidos en particular los paradigmas dominantes en macroeconomía y economía financiera, supone que hay un modelo “verdadero” del mundo, el cual se puede deducir de un conjunto de axiomas basados en la elección racional. Pero en realidad no hay, ni puede haber, un modelo que describa “el mundo tal como es realmente”. Los modelos son herramientas útiles en economía, e incluso indispensables, pero son necesariamente parciales, provisionales y específicos al contexto. El enfoque de la economía debe ser pluralista, es decir, debe usar el razonamiento inductivo y el razonamiento deductivo. El mapa no es el territorio.

  18. Ocupación del territorio litoral en ciudades turísticas de méxico

    OpenAIRE

    Baños Francia, José Alfonso

    2012-01-01

    En este trabajo se presenta el proceso de ocupación del territorio litoral en ciudades turísticas de México, país que alberga más de diez mil kilómetros de playa distribuidos en el océano Pacífico y en la costa Atlántica. La consolidación de los destinos de litoral se debe a la interacción de tres imaginarios turísticos: 1) el impulso político-institucional; 2) la oferta generada por los prestadores turísticos; y, 3) la satisfacción de la demanda de los turistas. Con ello, el espacio costero ...

  19. Breve historia del pueblo de Israel, ayer y hoy, ¿puede haber una esperanza de paz en ese territorio?

    Directory of Open Access Journals (Sweden)

    María Hernández-Sampelayo

    2010-01-01

    Full Text Available La historia del pueblo de Israel, desde la Antigüedad, iniciaría, a partir de su asentamiento en el territorio de Palestina, uno los conflictos más prolongados del siglo XX, aún no resuelto. El objetivo de este artículo es hacer un recorrido por la historia del pueblo de Israel, y profundizar en el análisis del conflicto árabe-israelí, analizando la viabilidad de un proceso de paz hasta hoy no concretado._____________ABSTRACT:The history of the Israeli people, since the Antiquity, would start with their settlement in the territory of Palestine, one of the largest conflicts of the XX century, still in process. The aim of this article is to make a panoramic of the Israeli history and deeply analyze the Arabic-Israeli conflict, analyzing the effectiveness of a peace process not finished until today.

  20. El territorio y la innovación: la red telegráfica mexicana, 1850-1910

    Directory of Open Access Journals (Sweden)

    Héctor Mendoza Vargas

    2013-08-01

    Full Text Available A mediados del siglo XIX, la telegrafía se convertía en una de las redes técnicas con mayor grado de penetración territorial en las economías europeas y de los Estados Unidos. De manera paralela y con las debidas adaptaciones técnicas, este trabajo indaga una de las redes territoriales desde la perspectiva de la geografía: la red mexicana de telegrafía y el paso de la red privada y regional a otra de carácter público y nacional, en un periodo clave, entre 1850 y 1910. La disposición de esta tecnología acentuó la centralidad de la ciudad de México, la modernización del Estado, la vigilancia e integración del territorio nacional.

  1. Il paesaggio di Matera nell'interpretazione cinematografica / Matera landscape in the cinematographic interpretation

    Directory of Open Access Journals (Sweden)

    Angelo Bencivenga

    2016-05-01

    Full Text Available Una definizione classica inquadra il paesaggio come natura percepita attraverso una cultura. Sulla "storicità" del paesaggio, alcuni autori hanno sottolineato la capacità del cinema di registrare le trasformazioni del territorio e allo stesso tempo di orientare lo sguardo su di esso. La Basilicata, a partire dal secondo dopoguerra, è stata terra di cinema; più di quaranta produzioni cinematografiche sono state realizzate sul suolo lucano. Una tendenza dominante, da Il Vangelo secondo Matteo di Pier Paolo Pasolini a Cristo si è fermato a Eboli di Francesco Rosi, ha messo in luce la condizione di miseria e arretratezza della Basilicata, influenzata da autori come Carlo Levi ed Ernesto De Martino. Interessante è il caso di Matera che, da espressione cinematografica di tale tendenza interpretativa, è diventata teatro di opere filmiche - come The Passion di Mel Gibson - che hanno contribuito a formare l'immagine di una città quasi mistica e culturalmente attiva. A classical definition of landscape is "nature perceived through a culture". On the "historicity" of the landscape, some authors have underlined the cinema’s capacity  to register the transformations of the territory and, at the same time, to direct the gaze on it. Since the end of the Second World War, the Basilicata region has been a film location; more than forty full length movies have been shot in Basilicata. Most of them, from The gospel according to St. Matthew by Pier Paolo Pasolini to Christ stopped at Eboli by Francesco Rosi, have shown the misery and the backwardness of Basilicata, inspired by the works of some authors as Carlo Levi and Ernesto De Martino. Matera is an interesting case study: from expression of this cinematic representation, in the last years it has become the location of some movies - like The Passion by Mel Gibson - that have had an important role in building the image of Matera as an almost mystic and culturally dynamic city.

  2. Il gioco le leggi naturali governano il caso

    CERN Document Server

    Eigen, Manfred

    1986-01-01

    Manfred Eigen, Premio Nobel per la chimica nel 1967, e la sua collaboratrice Ruthild Winkler hanno voluto con questo libro uscire allo scoperto, esponendo in una trattazione complessa ma comprensibile per ogni lettore veramente interessato una teoria molto audace, basata su ricerche e scoperte di Eigen stesso e di altri (come per esempio Thom e Prigogine) che in questi ultimi anni sono al centro dell’attenzione degli scienziati, anche se non sempre sono filtrate al di fuori della loro cerchia. Questa teoria ha come perno la nozione di gioco: e non già in una o più delle innumerevoli accezioni della parola, ma in tutte, con l’aggiunta di una ulteriore accezione che sottende tutte le altre: il gioco come struttura intelligibile emergente dal divenire caotico, quindi come fenomeno «che ha guidato fin dall’inizio il corso dell’Universo». Gioco, in questo libro, è dunque un «fenomeno naturale», non specificamente umano. I giochi che noi tutti giochiamo sono soltanto la schiuma variegata di un flutto...

  3. Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain

    Energy Technology Data Exchange (ETDEWEB)

    Jones, B.C.; Logsdon, N.J.; Walter, M.R. (UAB)

    2008-09-29

    IL-22 is an IL-10 family cytokine that initiates innate immune responses against bacterial pathogens and contributes to immune disease. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22R1 also pairs with the IL-20R2 chain to induce IL-20 and IL-24 signaling. To define the molecular basis of these diverse interactions, we have determined the structure of the IL-22/sIL-22R1 complex. The structure, combined with homology modeling and surface plasmon resonance studies, defines the molecular basis for the distinct affinities and specificities of IL-22 and IL-10 receptor chains that regulate cellular targeting and signal transduction to elicit effective immune responses.

  4. Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling

    NARCIS (Netherlands)

    Alves, Nuno L.; van Leeuwen, Ester M. M.; Derks, Ingrid A. M.; van Lier, René A. W.

    2008-01-01

    IL-7Ralpha is essential for the development and homeostatic maintenance of mature T cells. Studies in humans and mice have shown that IL-7Ralpha expression is reduced by its cognate cytokine, IL-7, and Ag, suggesting that active regulation of IL-7 responsiveness is necessary to balance T cell

  5. Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease

    NARCIS (Netherlands)

    Oosting, M.; Hofstede, H.J.M. ter; Veerdonk, F.L. van de; Sturm, P.D.J.; Kullberg, B.J.; Meer, J.W.M. van der; Netea, M.G.; Joosten, L.A.B.

    2011-01-01

    Interleukin-23 (IL-23) is known to play a crucial role in the development and maintenance of T helper 17 cells. It has been previously demonstrated that IL-17 is involved in experimental Lyme arthritis, caused by Borrelia burgdorferi bacteria. However, the precise role of the IL-23 receptor (IL-23R)

  6. Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation

    DEFF Research Database (Denmark)

    Galle, Pia; Jensen, Lene; Andersson, Christina

    2007-01-01

    IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; ...... principle might be a viable alternative in immune competent humans suffering from disorders driven by IL-6....

  7. Clinical value of determination of changes of serum Gas, IL-2, IL-10 and IL-18 levels after transfusion of Red blood cells in patients with peptic ulcer

    International Nuclear Information System (INIS)

    Liu Tingting; Li Xinghua

    2011-01-01

    Objective: To investigation the changes of serum Gas, IL-2, IL-10 and IL-18 contents after transfusion of red blood cells in patients with peptic ulcer. Methods: Serum Gas, IL-2, IL-10 (with RIA), serum IL-18 (with ELISA) levels were measured in 31 patients with peptic ulcer and 35 controls. Results: Before transfusion,the serum IL-2 level in the patients was significantly lower than that in controls (P 0.05). Conclusion: Detection of serum Gas, IL-2, IL-10 and IL-18 levels is clinically useful for monitoring progress and favourable prognosis of patients with peptic ulcer possess important clinical value. (authors)

  8. Il capriolo nel Pollino: ieri, oggi e domani

    Directory of Open Access Journals (Sweden)

    Alberto Sangiuliano

    2003-10-01

    rilevata anche fuori dai confini del Parco (nel comune di Lungro, ma anche nella porzione occidentale (comune di Orsomarso. Quest'espansione sembrerebbe meno evidente nei comparti più meridionali del comprensorio, dove, allo stato attuale, si rileva un modesto accrescimento dell?area di distribuzione solo in direzione sud-est. La distribuzione attuale della popolazione di capriolo dei Monti di Orsomarso si avvicinerebbe verosimilmente a 30.000 ha, confermando i risultati emersi dalla valutazione di idoneità ambientale; tale corrispondenza, oltre a trovare un chiaro riscontro in termini di habitat (soprattutto attraverso l?avvicinamento degli animali alle aree rurali, si esprime, attraverso la colonizzazione di alcune delle aree indicate come ?le più probabili? nella carta di idoneità. Il Parco Nazionale del Pollino sembrerebbe quindi un territorio rilevante per l?estensione di una porzione ?insulare? dell?areale della sottospecie C.c. italicus di elevata importanza conservazionistica.

  9. IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes.

    Science.gov (United States)

    Gagnon, Julien; Ramanathan, Sheela; Leblanc, Chantal; Cloutier, Alexandre; McDonald, Patrick P; Ilangumaran, Subburaj

    2008-06-15

    Recent reports have shown that IL-21, in synergy with IL-15, stimulates proliferation of CD8(+) T lymphocytes in the absence of signaling via the TCR. In this study, we show that IL-6, which induces phosphorylation of STAT3 similarly to IL-21, also can stimulate proliferation of CD8(+) T cells in synergy with IL-7 or IL-15. IL-6 displays a stronger synergy with IL-7 than with IL-15 to stimulate naive CD8(+) T cells. Concomitant stimulation by IL-6 or IL-21 augments phosphorylation and DNA-binding activity of STAT5 induced by IL-7 or IL-15. Like IL-21, IL-6 reduces the TCR signaling threshold required to stimulate CD8(+) T cells. Prior culture of P14 TCR transgenic CD8 T cells with IL-6 or IL-21 in the presence of IL-7 or IL-15 augments their proliferation and cytolytic activity upon subsequent stimulation by Ag. Furthermore, cytokine stimulation induces quantitatively and qualitatively distinct phenotypic changes on CD8(+) T cells compared with those induced by TCR signaling. We propose that the ability of IL-6 to induce TCR-independent activation of CD8(+) T cells in synergy with IL-7 or IL-15 may play an important role in the transition from innate to adaptive immunity.

  10. Expression of IL33 and IL35 in oral lichen planus.

    Science.gov (United States)

    Javvadi, L R; Parachuru, V P B; Milne, T J; Seymour, G J; Rich, Alison M

    2018-04-09

    Oral lichen planus (OLP) is a complex immunological disorder, mediated in part by the release of cytokines by activated T-cells. Recently, the role of novel cytokines including IL33 and IL35 has been described in various chronic inflammatory diseases. IL33, a member of the IL-1 superfamily of cytokines, functions as an 'alarmin' released after cell necrosis to alert the immune system to tissue damage or stress. IL35, a member of IL12 cytokine family, is produced by regulatory T-cells and suppresses the immune response. The expression of IL33 and IL35 is yet to be investigated in OLP. The aim of this study was to determine the presence and topographical distribution of IL33 and IL35 in OLP using immunohistochemistry and quantitative real-time reverse transcriptase polymerase chain reaction (qPCR). For IHC, formalin-fixed paraffin-embedded archival specimens of OLP (n = 10) and a non-specific inflammatory (NSI) control group (n = 9) were used. A double-labelling immunofluorescence technique was used to determine the expression of IL33 and IL35 on CD3 + T-cells. In addition, 12 fresh tissue samples (OLP n = 6 and NSI controls n = 6) were used to determine the gene expression of IL33 and EBI3 (one chain of the dimeric IL35). Quantitative and qualitative analysis was performed with statistical significance set at p < 0.05. IHC showed positive immunostaining with IL33 and IL35 in both OLP and NSI. Comparison of the numbers of IL33 + and IL35 + cells in OLP and NSI did not show any significant difference. In OLP, there were significantly more IL33 + cells in the deeper connective tissue region than at the epithelial-connective tissue interface. Interestingly, all IL35 + cells observed in both OLP and NSI tissues showed ovoid/plasmacytoid morphology. Double-labelling immunofluorescence showed that IL33 and IL35 expression was not localized within CD3 + T-cells. The gene expression experiments showed significantly higher expression of EBI3 (fold

  11. Expanding Diversity in Molecular Structures and Functions of the IL-6/IL-12 Heterodimeric Cytokine Family

    Directory of Open Access Journals (Sweden)

    Hideaki Hasegawa

    2016-11-01

    Full Text Available The interleukin (IL-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they are composed of two distinct subunits forming a heterodimer and each cytokine and receptor subunit shares with each other. The members of this cytokine family are increasing; currently, there are more than 6 cytokines, including the tentatively named cytokines IL-Y (p28/p40, IL-12 (p35/p40, IL-23 (p19/p40, IL-27 p28/Epstein-Barr virus-induced protein 3 (EBI3, IL-35 (p35/EBI3, and IL-39 (p19/EBI3. This family of cytokines covers a very broad range of immune responses, including pro-inflammatory responses such as helper T (Th1, Th2, and Th17 to anti-inflammatory responses such as regulatory T (Treg cells and IL-10-producing Treg cells. IL-12 is the first member of this family, and IL-12, IL-23, and IL-27 are mainly produced by activated antigen-presenting cells such as dendritic cells and macrophages. IL-12 plays a critical role in the promotion of Th1 immune responses by inducing interferon-γ production to combat pathogens and malignant tumors. IL-23 induces IL-17 production and is necessary to maintain pathogenic Th17 cells that cause inflammatory and autoimmune diseases. IL-27 was initially reported to play a critical role in promotion of Th1 differentiation; however, subsequent studies revealed that IL-27 has broader stimulatory and inhibitory roles by inducing IL-10-producing Treg cells. IL-35 is produced by forkhead box P3+ Treg cells and activated B cells and has immunosuppressive functions to maintain immune tolerance. The most recently identified cytokine, IL-39, is produced by activated B cells and has pro-inflammatory functions. The cytokine tentatively named IL-Y seems to have anti-inflammatory functions by inhibiting Th1 and Th17 differentiation. In addition, individual cytokine subunits were also shown to have self-standing activities. Thus

  12. IL-21 Receptor Expression in Human Tendinopathy

    Science.gov (United States)

    Campbell, Abigail L.; Smith, Nicola C.; Reilly, James H.; Kerr, Shauna C.; Leach, William J.; Fazzi, Umberto G.; Rooney, Brian P.; Murrell, George A. C.; Millar, Neal L.

    2014-01-01

    The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level. The level of expression of IL-21R message/protein in human tenocytes was significantly upregulated by proinflammatory cytokines (TNFα/IL-1β) in vitro. These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages. Despite a lack of IL-21 expression, these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy. PMID:24757284

  13. IL-21 Receptor Expression in Human Tendinopathy

    Directory of Open Access Journals (Sweden)

    Abigail L. Campbell

    2014-01-01

    Full Text Available The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level. The level of expression of IL-21R message/protein in human tenocytes was significantly upregulated by proinflammatory cytokines (TNFα/IL-1β in vitro. These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages. Despite a lack of IL-21 expression, these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy.

  14. Il Gambling Compulsivo: rilevanza epidemiologica

    Directory of Open Access Journals (Sweden)

    A. Coacci

    2003-05-01

    Full Text Available

    Introduzione: il gioco d’azzardo ha profonde radici nella storia e nella cultura di ogni popolo. Si stima che circa l’80% della popolazione adulta nel nostro Paese giochi d’azzardo. Esso, pur rappresentando per la maggior parte di queste persone solo un innocuo passatempo, si trasforma talora in una vera e propria malattia (gambling compulsivo, con comportamenti che denotano forme estreme di rischio, sino a forme che portano alla distruzione della famiglia e persino della propria vita.

    Si tratta un disturbo poco conosciuto e spesso non diagnosticato. Infatti, benché sia largamente diffuso e comporti rilevanti costi umani e sociali, il gambling compulsivo solo di recente è stato incluso nelle classificazioni diagnostiche internazionali.

    Obiettivi: valutare l’impatto epidemiologico del gambling compulsivo (gioco d’azzardo patologico in una ASL/provincia.

    Materiali e metodi: è stato inviato un questionario ai 190 Medici di Medicina Generale della provincia di Grosseto (ASL 8, per raccogliere informazioni su: sistema di cura, numero di soggetti che si sono rivolti al proprio medico di famiglia per tale problema, eventuale coesistenza di problemi e comportamenti di dipendenza e di abuso (alcool, psicofarmaci, droghe illegali, ecc.

    Risultati: sono pervenuti 127 (pari al 66,8% questionari compilati. L’elaborazione dei dati è tuttora in corso.

    Conclusioni: dai risultati preliminari sembra emergere che il numero di persone che chiede aiuto al medico e al SSN, differentemente da quanto accade per i tossicodipendenti, è molto limitato e, quindi, intuitivamente poco indicativo della massa di soggetti realmente coinvolti dalla problematica studiata. Si discute del ruolo nella promozione della salute potenzialmente svolto dai Medici di Medicina Generale. Per quanto la tecnica di rilevazione appaia relativamente poco sensibile

  15. IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF)

    DEFF Research Database (Denmark)

    Willerslev-Olsen, Andreas; Litvinov, Ivan V; Fredholm, Simon M

    2014-01-01

    Skin lesions from mycosis fungoides (MF) patients display an increased expression of interleukin-15 (IL-15), IL-17F, and other cytokines implicated in inflammation and malignant cell proliferation in cutaneous T-cell lymphoma (CTCL). In the leukemic variant of CTCL, Sézary syndrome (SS), IL-2...... and IL-15 trigger activation of the Jak-3/STAT3 pathway and transcription of IL17A gene, whereas it is unknown what causes IL-15 expression, Jak3/STAT3 activation, and production of IL-17F in MF. Here, we studied the expression and regulation of IL-15 and its relation to IL-17F in MF cell lines and skin......-malignant MF T cells, whereas the spontaneous STAT3 activation and IL-17F expression in malignant T cells is not inhibited; (3) patients display heterogeneous IL-15/IL-17F mRNA expression patterns in skin lesions; and (4) IL-15 expression (in contrast to IL-17F) is not associated with progressive disease...

  16. 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

    Directory of Open Access Journals (Sweden)

    Anna Bonanno

    2014-01-01

    Full Text Available Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC, 11 allergic rhinitis (AR patients, and 35 allergic asthma with rhinitis (AAR patients. We found significant lower levels of 25(OH Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH Vit D. In AAR 25(OH Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH Vit D in AR and AAR. In conclusion, low levels of 25(OH Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity.

  17. IL-28 and IL-29 as protective markers in subject with dengue fever.

    Science.gov (United States)

    Hung, Chih-Hsing; Huang, Chung-Hao; Wang, Lin; Huang, Chun-Chi; Wu, Meng-Chieh; Chin, Yi-Ying; Lin, Chun-Yu; Chang, Ko; Wu, Deng-Chyang; Chen, Yen-Hsu

    2017-06-01

    About 400 million people every year are estimated to contract dengue virus infection, which causes prolonged morbidity and sometimes mortality. Interleukin (IL)-28 and IL-29 are relatively newly discovered cytokines and play an important role in our immune defense against pathogens, especially for viral infection. In the present study, we investigated serum IL-28 and IL-29 expression and the relationship to clinical and laboratory parameters in patients with dengue virus infection. Adult patients with dengue (n = 45) and control group (n = 24) were included prospectively. Clinical symptoms and laboratory data were collected from every patient. We investigated IL-28 and IL-29 levels in serum by ELISA. The concentrations of serum IL-28 and IL-29 were significantly higher in subjects with dengue when compared to those of control group. The patients with higher serum IL-28 and IL-29 levels had significantly lower ALAT and peripheral blood neutrophil percentage, but higher peripheral platelet, total white blood cell (WBC), monocyte, and lymphocyte counts. Patients with higher serum IL-28 and IL-29 levels also had more flu-like symptoms, but less vomiting. Increased level of IL-28 and IL-29 was associated with better liver function, platelet and WBC numbers and clinical symptom in subjects with dengue and could potentially serve as a protective marker.

  18. IL-36γ Is a Strong Inducer of IL-23 in Psoriatic Cells and Activates Angiogenesis

    Directory of Open Access Journals (Sweden)

    Charlie Bridgewood

    2018-02-01

    Full Text Available The IL-1 family member cytokine IL-36γ is recognised as key mediator in the immunopathology of psoriasis, hallmarks of which involve the activation of both resident and infiltrating inflammatory myeloid cells and aberrant angiogenesis. This research demonstrates a role for IL-36γ in both myeloid activation and angiogenesis. We show that IL-36γ induces the production of psoriasis-associated cytokines from macrophages (IL-23 and TNFα and that this response is enhanced in macrophages from psoriasis patients. This effect is specific for IL-36γ and could not be mimicked by other IL-1 family cytokines such as IL-1α. IL-36γ was also demonstrated to induce endothelial tube formation and branching, in a VEGF-A-dependent manner. Furthermore, IL-36γ-stimulated macrophages potently activated endothelial cells and led to increased adherence of monocytes, effects that were markedly more pronounced for psoriatic macrophages. Interestingly, regardless of stimulus, psoriasis monocytes showed increased adherence to both the stimulated and unstimulated endothelium when compared with monocytes from healthy individuals. Collectively, these findings show that IL-36γ has the potential to enhance endothelium directed leucocyte infiltration into the skin and strengthen the IL-23/IL-17 pathway adding to the growing evidence of pathogenetic roles for IL-36γ in psoriatic responses. Our findings also point to a cellular response, which could potentially explain cardiovascular comorbidities in psoriasis in the form of endothelial activation and increased monocyte adherence.

  19. IL-36γ Is a Strong Inducer of IL-23 in Psoriatic Cells and Activates Angiogenesis.

    Science.gov (United States)

    Bridgewood, Charlie; Fearnley, Gareth W; Berekmeri, Anna; Laws, Philip; Macleod, Tom; Ponnambalam, Sreenivasan; Stacey, Martin; Graham, Anne; Wittmann, Miriam

    2018-01-01

    The IL-1 family member cytokine IL-36γ is recognised as key mediator in the immunopathology of psoriasis, hallmarks of which involve the activation of both resident and infiltrating inflammatory myeloid cells and aberrant angiogenesis. This research demonstrates a role for IL-36γ in both myeloid activation and angiogenesis. We show that IL-36γ induces the production of psoriasis-associated cytokines from macrophages (IL-23 and TNFα) and that this response is enhanced in macrophages from psoriasis patients. This effect is specific for IL-36γ and could not be mimicked by other IL-1 family cytokines such as IL-1α. IL-36γ was also demonstrated to induce endothelial tube formation and branching, in a VEGF-A-dependent manner. Furthermore, IL-36γ-stimulated macrophages potently activated endothelial cells and led to increased adherence of monocytes, effects that were markedly more pronounced for psoriatic macrophages. Interestingly, regardless of stimulus, psoriasis monocytes showed increased adherence to both the stimulated and unstimulated endothelium when compared with monocytes from healthy individuals. Collectively, these findings show that IL-36γ has the potential to enhance endothelium directed leucocyte infiltration into the skin and strengthen the IL-23/IL-17 pathway adding to the growing evidence of pathogenetic roles for IL-36γ in psoriatic responses. Our findings also point to a cellular response, which could potentially explain cardiovascular comorbidities in psoriasis in the form of endothelial activation and increased monocyte adherence.

  20. IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations

    Directory of Open Access Journals (Sweden)

    Hyun-Jung Park

    2015-01-01

    Full Text Available It has been known that activation of the central innate immune system or exposure to stress can disrupt balance of anti-/proinflammatory cytokines. The aim of the present study was to investigate the role of pro- and anti-inflammatory cytokines in the modulation of depressive-like behaviors, the hormonal and neurotransmitter systems in rats. We investigated whether centrally administered IL-1β is associated with activation of CNS inflammatory pathways and behavioral changes and whether treatment with IL-4 could modulate IL-1β-induced depressive-like behaviors and central neurotransmitter systems. Infusion of IL-4 significantly decreased IL-1β-induced anhedonic responses and increased social exploration and total activity. Treatment with IL-4 markedly blocked IL-1β-induced increase in PGE2 and CORT levels. Also, IL-4 reduced IL-1β-induced 5-HT levels by inhibiting tryptophan hydroxylase (TPH mRNA and activating serotonin transporter (SERT in the hippocampus, and levels of NE were increased by activating tyrosine hydroxylase (TH mRNA expression. These results demonstrate that IL-4 may locally contribute to the regulation of noradrenergic and serotonergic neurotransmission and may inhibit IL-1β-induced behavioral and immunological changes. The present results suggest that IL-4 modulates IL-1β-induced depressive behavior by inhibiting IL-1β-induced central glial activation and neurotransmitter alterations. IL-4 reduced central and systemic mediatory inflammatory activation, as well as reversing the IL-1β-induced alterations in neurotransmitter levels. The present findings contribute a biochemical pathway regulated by IL-4 that may have therapeutic utility for treatment of IL-1β-induced depressive behavior and neuroinflammation which warrants further study.

  1. Autophagy and IL-1 family cytokines

    Directory of Open Access Journals (Sweden)

    James eHarris

    2013-04-01

    Full Text Available Autophagy is an important intracellular homeostatic mechanism for the targeting of cytosolic constituents, including organelles, for lysosomal degradation. Autophagy plays roles in numerous physiological processes, including immune cell responses to endogenous and exogenous pathogenic stimuli. Moreover, autophagy has a potentially pivotal role to play in the regulation of inflammatory responses. In particular, autophagy regulates endogenous inflammasome activators, as well as inflammasome components and pro-IL-1β. As a result, autophagy acts a key modulator of IL-1β and IL-18, as well as IL-1α, release. This review focuses specifically on the role autophagy plays in regulating the production, processing and secretion of IL-1 and IL-18 and the consequences of this important function.

  2. Increased IL-20 and IL-24 target osteoblasts and synovial monocytes in spondyloarthritis

    DEFF Research Database (Denmark)

    Kragstrup, Tue Wenzel; Andersen, Morten Nørgaard; Schiøttz-Christensen, Berit

    2017-01-01

    The pathogenesis of spondyloarthritis (SpA) involves activation of the innate immune system, inflammation and new bone formation. The two cytokines interleukin (IL)-20 and IL-24 have been shown to link innate immune activation and tissue homeostasis. We hypothesized that these two cytokines...... are secreted as part of activation of the innate immune system and affect bone homeostasis in SpA. IL-20 and IL-24 were measured in plasma from axial SpA patients (n = 83). Peripheral SpA patients (n = 16) were included for in-vitro cell culture studies. The plasma IL-20 and IL-24 levels were increased in Sp...

  3. Roles of elevated intravitreal IL-1β and IL-10 levels in proliferative diabetic retinopathy

    OpenAIRE

    Mao, Chunjie; Yan, Hua

    2014-01-01

    Purpose: To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR). Materials and Methods: Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA). Results: Levels of IL-1β and IL-10 in vitreous were higher in PDR patients compared with control group. And there ...

  4. The role of CD40L, IL-10 and IL-17 in radioprotection

    International Nuclear Information System (INIS)

    Li Ting

    2003-01-01

    CD40L/CD40 interaction is central to the control of thymus-dependent humoral immunity and cell mediated immune responses. IL-17 has been shown to induce the production of IL-6 and G-CSF, which can induce proliferation and differentiation of CD34 + hematopoietic progenitors. IL-10 can interfere with up-regulation of costimulatory molecules, thus suppressing the production of costimulatory cytokines, such as IL-12. IL-10 has been implicated as an essential mediator in the induction of systemic immune suppression following ultraviolet (UV) exposure. Treating UV-irradiated mice with anti-IL-10 blocks the induction of immune suppression

  5. Il fuoco della fusione termonucleare controllata

    CERN Document Server

    Caldirola, Piero; Sindoni, Elio

    1984-01-01

    Per realizzare la fusione termonucleare controllata, cioè catturare e dominare il fuoco che accende gli astri, e ottenere così una nuova fonte di energia praticamente illimitata e a basso costo, si richiede uno sforzo collettivo e unitario globale: non esiste infatti nazione al mondo che sia in grado, singolarmente presa, di affrontare il problema, sia per le risorse finanziarie necessarie all'impresa sia per il numero dei ricercatori che dovranno dedicarvisi.

  6. Il welfare aziendale nella crisi dello Stato

    OpenAIRE

    Caracciolo di Melissano, Francesco Pio

    2016-01-01

    La crisi economica iniziata nel 2007, da un lato ha determinato il sorgere di nuove e diversificate esigenze dei lavoratori, dall’altro ha indotto gli Stati a ridurre le risorse destinate al welfare. In questo contesto, le iniziative di welfare dei privati, racchiuse sotto la denominazione “welfare aziendale o di secondo livello”, hanno assunto un ruolo determinante nel garantire il benessere sociale ed in particolare quello dei lavoratori e delle loro famiglie. Il legislatore, da ultimo con ...

  7. Il viaggio gastronomico di Paolo Monelli.

    OpenAIRE

    Salarelli, Alberto

    2013-01-01

    Il ghiottone errante di Paolo Monelli, pubblicato nel 1935, rappresenta uno dei primi esempi di narrativa di viaggio in tema di enogastronomia, un genere destinato a grande successo nel secondo dopoguerra. In questo articolo, oltre a ripercorrere la vicenda biografica di Monelli, si sottolineano le relazioni tra Il ghiottone e la cultura gastronomica del regime fascista, e si evidenziano alcuni tratti caratteristici del suo stile di scrittura. Paolo Monelli‟s Il ghiottone errante (The Wand...

  8. IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures

    DEFF Research Database (Denmark)

    Blom, Lars; Poulsen, Lars K.

    2012-01-01

    The IL-1 family members IL-1ß, IL-18, and IL-33 are potent cytokines in relationship to amplifying the CD4(+) T cell cytokine production. To evaluate their impact on in vitro-differentiated human Th1 and Th2 cultures, such cultures were established from naive T cells, purified from healthy blood...... donors, and reactivated in the presence of IL-1ß, IL-18, or IL-33. Interestingly, we observe modifying responses in Th1 and Th2 cultures induced by IL-18 or IL-33 but not by IL-1ß, both contributing to amplify production of IL-5, IL-13, and IFN-¿. IL-18 or IL-33 stimulation of Th1 cultures resulted...... in increased IFN-¿ and IL-13 production concurrent with reduced IL-10 gene transcription and secretion even though Th1 cultures, in contrast to IL-18Ra, had low ST2L expression. Furthermore, adding IL-18 to Th1 cultures promoted Tbet mRNA expression and production. Th2 cultures stimulated with IL-18 or IL-33...

  9. Sinergetica il segreto del successo della natura

    CERN Document Server

    Haken, Hermann

    1983-01-01

    Introduzione e sommario ; il disordine cresce sempre? la morte termica dell'universo ; i cristalli : strutture ordinate, ma morte ; strutture ordinate nei liquidi e nelle nubi e formazioni geologiche ; fiat lux! la luce del laser ; configurazioni chimiche ; l'evoluzione biologica e la sopravvivenza del migliore ; sopravvivi anche senza essere il migliore : specializzati, scavati una nicchia ecologica ; come si formano gli organismi biologici ; talvolta i conflitti sono ineluttabili ; il caos, il caso e la concezione meccanicistica del mondo ; gli effetti sinergetici nell'economia ; si possono prevedere le rivoluzioni ? ; le allucinazioni comprovano le teorie sul cervello.

  10. Il caso Lautsi contro l’Italia

    Directory of Open Access Journals (Sweden)

    Grégor Puppinck

    2012-02-01

    SOMMARIO: 1. Premesse – 2. Il ragionamento della Seconda Sezione - 2.1. La ridefinizione dalla finalità del sistema educativo pubblico - 2.2. Il pluralismo educativo come finalità – 2.3. Sintesi del ragionamento della Sezione – 2.4.  Una sentenza contestata - 3.  Il ragionamento sviluppato dalla Grande Camera - 3.1. La sussidiarietà e il margine di apprezzamento – 3.2.  Il laicismo è una convinzione filosofica non neutra – 3.3. La neutralità si applica all’ “agire” e non all' "essere” dello  Stato – 3.4.  Democrazia, neutralità confessionale e laicità – 3.5.  L’educazione pubblica  nel senso della Grande Camera – 3.6.  Il crocefisso: un simbolo passivo – 3.7.  L’assenza d’ingerenza dello Stato - 4.  Gli sviluppi supplementari alla sentenza della Grande Camera – 4.1.  Il crocefisso e il velo islamico – 4.2.  La libertà negativa di religione dei non credenti – 4.3. La falsa soluzione bavarese – 4.4.  La tradizione – 4.5. La religione maggioritaria – 4.6.  Il dibattito religioso e politico – 4.7. Le conseguenze del caso Lautsi.

  11. Editorial. La naturaleza y comprensión del territorio a través del hecho y memoria social

    Directory of Open Access Journals (Sweden)

    Jorge Inzulza Contardo

    2015-12-01

    Full Text Available En la actualidad, hablar del territorio habitado, parece ser más apropiado que solamente centrar los distintos hechos sociales en la ciudad o, en un sentido un poco más amplio, en el contexto urbano. En ese sentido, la comprensión del territorio requiere de visiones refrescadas y la inclusión de la compleja relación entre las escalas de territorio y sus aspectos basales de sustentabilidad energética y económica, así como el diseño y planificación del territorio. En el presente número, se presenta una conjunción de trabajos que abordan estas problemáticas multidisciplinarias, y desde básicamente tres esferas de la investigación: la naturaleza del territorio y sus sistemas hídricos y económico-productivos, la importancia de diseño como moderador del paisaje urbano, y el imaginario colectivo como el registro más diáfano de interpretación del espacio vivido. En primer lugar y desde un prisma geográfico, dos trabajos encabezan y aportan de manera ilustrada, con una mirada sobre la dinámica del sistema urbano-regional costero, y desde dos ámbitos. El primero de escala internacional, en donde María Christina Fragkou, Teresa Vicent, Xavier Gabarrell, relevan la importancia de los flujos energéticos como herramienta de análisis territorial. A través de la revisión del caso de la Región Metropolitana de Barcelona, las autoras reflexionan en que “el estudio del metabolismo energético a escala urbana y regional es una herramienta” que permite replicar el uso de la energía y se plasmada en ”concretas propuestas de planificación con el fin de ahorrar recursos y alcanzar el objetivo de la autosuficiencia energética”. De esta forma, una ciudad más eficiente energéticamente sin duda incluye la anhelada sustentabilidad. Por su parte, Antonio Daher pone en discusión desde la visión nacional y regional norte, como la estrategia de “cluster minero” en Antofagasta, cuya región es emblemática del modelo exportador

  12. Movilidad de trabajadores y construcción social del territorio en el Alto Valle de Río Negro

    Directory of Open Access Journals (Sweden)

    Martha Radonich

    2009-12-01

    Full Text Available En el norte de la Patagonia Argentina, el tradicional espacio del Alto Valle de Río Negro, se orientó desde sus inicios a actividades vinculadas a la exportación de fruta fresca, asimismo, ha sido punto de confluencia de circulación no sólo de capital y mercancías sino también de mano de obra. Al consolidarse la fruticultura entre 1940 y 1950, migrantes de origen chileno y del interior de las provincias de Neuquén y Río Negro llegaron a la zona para emplearse en las chacras. Algunos de ellos, junto a sus familias, optaron por conformar pequeños núcleos de población próximos a las explotaciones agrícolas, constituyendo territorios con características particulares. En este trabajo presentaremos algunas aproximaciones a la construcción social de territorios de trabajadores y a la movilidad espacial de esta fuerza de trabajo, relacionadas con las transformaciones en la producción de peras y manzanas en el Alto Valle de Río Negro.The traditional space of the Alto Valle of Rio Negro in the north Argentinean Patagonia, was orientated from his beginnings to activities linked to the exportation of fresh fruit, likewise, it has been a point of confluence of traffic not only of capital and goods but also of labor. On the fruit-growing having consolidated between1940 and 1950, migrants from Chilean origin and from the provinces of Neuquén and Rio Negro came to the zone to work in the farms. Some of these new comers settled in small population near the agricultural areas, constituting territories with particular characteristics. In this work we will present some approximations to the social construction of workers' territories and to the spatial mobility of this workforce, related to the transformations in the production of pears and apples in the Alto Valle of Rio Negro.

  13. SASSEN, SASKIA (2010. Territorio, autoridad y derechos: de los ensamblajes medievales a los enssamblajes globales, madrid: katz

    Directory of Open Access Journals (Sweden)

    Alena Profit

    2013-12-01

    Full Text Available This review analyzes Saskia Sassen’s book “Territorio, autoridad y derechos: De los ensamblajes medievales a los ensamblajes globales”. The general question the book elaborates onis: How to study and theorize foundational transformations in and of complex systems? Globalization has become a veritable key word of our time, but its relation to the processes of denationalization within the nation-state as principal trigger of this process remains undertheorized. Sassen’s argument concentrates on the idea that the national paves the way for the global. By analyzing the three socio-political components territory authority and rights, through the analytical categories tipping points, capabilities and organizing logics, the sociologist follows their changes and interactions in three historical eras, the medieval, the national and the global realm. Given the complex frameworks the transformations operate in, it is pointed out that the interdependencies of the denationalization processes require a historical approach to overcome one-sided analytical perspectives. keywords: assemblages, denationalization, globalization, nation-state --- Esta resenha analisa o livro de Saskia Sassen "Territorio, autoridad y derechos de los: ensamblajes Medievales a los ensamblajes Globales". A questão geral do livro elabora onis: Como estudar e teorizar as transformações fundamentais dentro e de sistemas complexos? A globalização tornou-se verdadeira palavra-chave do nosso tempo, mas sua relação com os processos de desnacionalização dentro do Estado-nação, como o principal gatilho desse processo, permanece subteorizada. O argumento de Sassen concentra-se na idéia de que o nacional prepara o caminho para o global. Ao analisar os três componentes sócio-políticos, a autoridade, o território, e os direitos através dos "tipping points" das categorias analíticas, das capacidades e organizações lógicas, o sociólogo segue suas mudanças e intera

  14. Evidence for Involvement of IL-9 and IL-22 in Cows' Milk Allergy in Infants.

    Science.gov (United States)

    Barros, Karina V; Flor Silveira, Vera L; Laranjeira, Marisa S; Wandalsen, Neusa F; Passeti, Susana; de Oliveira, Roberta; Munekata, Regina V; Noakes, Paul S; Miles, Elizabeth A; Calder, Philip C

    2017-09-21

    Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 ± 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula ( n = 26) or a free amino acid formula ( n = 20). Blood samples were collected before treatment during active disease (T0) and after 120 days, when symptoms were absent (T1). Plasma cytokine concentrations were measured. Infants with CMA had higher plasma concentrations of interleukin (IL)-4 and IL-13 and lower concentrations of IL-9, IL-17A and interferon-γ, compared with healthy breast-fed infants. At T0, there was a positive correlation between blood eosinophil numbers and plasma concentrations of IL-4, IL-9, IL-17A and IL-22. Treatment with a cows' milk elimination diet resulted in a decrease in plasma IL-4, IL-9, IL-13 and IL-22 and an increase in plasma IL-17A. We conclude that IL-4 and IL-13 are elevated in active CMA. The association of IL-9 and IL-22 with eosinophilia, and the decrease in these two cytokines with cows' milk elimination, suggests that they both play a role in the symptoms observed in CMA and may be important targets for future interventions.

  15. Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases

    Directory of Open Access Journals (Sweden)

    Gabriele Fenini

    2017-05-01

    Full Text Available In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs. Activation of the inflammasomes results in the processing and subsequent secretion of the pro-inflammatory cytokines IL-1β and IL-18. Several autoinflammatory disorders such as cryopyrin-associated periodic syndromes and Familial Mediterranean Fever have been associated with mutations of genes encoding inflammasome components. Moreover, the importance of IL-1 has been reported for an increasing number of autoinflammatory skin diseases including but not limited to deficiency of IL-1 receptor antagonist, mevalonate kinase deficiency and PAPA syndrome. Recent findings have revealed that excessive IL-1 release induced by harmful stimuli likely contributes to the pathogenesis of common dermatological diseases such as acne vulgaris or seborrheic dermatitis. A key pathogenic feature of these diseases is IL-1β-induced neutrophil recruitment to the skin. IL-1β blockade may therefore represent a promising therapeutic approach. Several case reports and clinical trials have demonstrated the efficacy of IL-1 inhibition in the treatment of these skin disorders. Next to the recombinant IL-1 receptor antagonist (IL-1Ra Anakinra and the soluble decoy Rilonacept, the anti-IL-1α monoclonal antibody MABp1 and anti-IL-1β Canakinumab but also Gevokizumab, LY2189102 and P2D7KK, offer valid alternatives to target IL-1. Although less thoroughly investigated, an involvement of IL-18 in the development of cutaneous inflammatory disorders is also suspected. The present review describes the role of IL-1 in diseases with skin involvement and gives an overview of the relevant studies discussing the therapeutic potential of modulating the secretion and activity of IL-1 and IL-18 in such diseases.

  16. Cambios en la organización económico-espacial de la fruticultura en territorios de La Araucanía, Chile

    Directory of Open Access Journals (Sweden)

    Miguel Antonio Escalona-Ulloa

    2014-01-01

    Full Text Available El artículo aborda el potencial de expansión de la actividad frutícola en la región de La Araucanía, identificando territorios que presentan aptitud para su desarrollo futuro. Se realiza un análisis histórico y se elabora un modelo espacial para definir áreas aptas, el resultado permite reconocer la existencia de dos territorios específicos: Malleco Norte, conformados por Angol, Renaico y Collipulli, y Cautín sur, integrado por las comunas de Freire, Pitrufquén, Gorbea, Loncoche y Villarrica, en estos espacios es posible expandir aún más la actividad pero se requiere mejorar la infraestructura e incorporar un enfoque territorial al desarrollo productivo regional.

  17. Ciencia y recursos naturales a través del Periódico Oficial del Gobierno del Territorio de Quintana Roo, 1936-1940

    Directory of Open Access Journals (Sweden)

    Rodrigo Antonio Vega y Ortega Báez

    2017-06-01

    Full Text Available Entre 1936 y 1940, Rafael E. Melgar gobernó el Territorio de Quintana Roo. En este lapso, se publicaron en el Periódico Oficial del Gobierno del Territorio de Quintana Roo varios escritos sobre la explotación de la flora. El objetivo es comprender la valoración científica de los recursos vegetales de Quintana Roo en dicho periodo. La metodología retoma aspectos de la historia de la ciencia para demostrar algunos de los propósitos del gobierno de Melgar en torno a la exploración científica. En las conclusiones se destaca que el gobierno se interesó en elaborar el inventario botánico para modernizar la economía.

  18. ¿fronteras naturales? geopolítica modernista y ecopolítica ambientalista en territorio awá: bios y thanatos en el margen

    OpenAIRE

    Naizot, Anne-Lise

    2011-01-01

    La creación de espacios extractivos, agroindustriales y ecológicos en los territorios indígenas plantea una serie de interrogantes sobre el futuro de esos territorios y, especialmente, sobre el proyecto de autonomía territorial y política de los pueblos indígenas en América Latina y el mundo. Esos espacios son ante todo espacios sociales y están atravesados por relaciones de poder que definen fronteras móviles entre la vida y la muerte, la dominación y la autonomía, la inclusión y la exclusió...

  19. Naturaleza(s), poder, sujeto(s) en territorio Awá : Bios y Thanatos en el margen socio-ambiental

    OpenAIRE

    Naizot, Anne-Lise

    2011-01-01

    La creación de espacios extractivos, tóxicos, y ecológicos en los territorios indígenas plantean una serie de interrogaciones para el futuro de esos territorios y el proyecto de autonomía territorial y política de los pueblos indígenas en América Latina y en el mundo. Esos espacios son, antes que todo, espacios sociales; son atravesados por relaciones de poder que definen fronteras móviles entre la vida y la muerte, la dominación y la autonomía, la inclusión y la exclusión. Este trabajo indag...

  20. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria

    Directory of Open Access Journals (Sweden)

    Akiko Shibui

    2016-03-01

    Full Text Available IL-25, IL-33 and TSLP, which are produced predominantly by epithelial cells, can induce production of Th2-type cytokines such as IL-4, IL-5 and/or IL-13 by various types of cells, suggesting their involvement in induction of Th2-type cytokine-associated immune responses. It is known that Th2-type cytokines contribute to host defense against malaria parasite infection in mice. However, the roles of IL-25, IL-33 and TSLP in malaria parasite infection remain unclear. Thus, to elucidate this, we infected wild-type, IL-25−/−, IL-33−/− and TSLP receptor (TSLPR−/− mice with Plasmodium berghei (P. berghei ANKA, a murine malaria strain. The expression levels of IL-25, IL-33 and TSLP mRNA were changed in the brain, liver, lung and spleen of wild-type mice after infection, suggesting that these cytokines are involved in host defense against P. berghei ANKA. However, the incidence of parasitemia and survival in the mutant mice were comparable to in the wild-type mice. These findings indicate that IL-25, IL-33 and TSLP are not critical for host defense against P. berghei ANKA.

  1. Psoriasis is not associated with IL-12p70/IL-12p40 production and IL12B promoter polymorphism

    DEFF Research Database (Denmark)

    Litjens, Nicolle H R; van der Plas, Mariena J A; Ravensbergen, Bep

    2004-01-01

    Psoriasis is a type-1 T cell-mediated, chronic inflammatory disease. Since interleukin (IL)-12p70 promotes the development of type-1 T cells, we investigated whether psoriasis is associated with an increased production of this cyctokine by blood cells. Results revealed that the production of IL-1...

  2. Política nacional de uso del borde costero: un análisis desde el punto de vista de su impacto en el ordenamiento del territorio

    Directory of Open Access Journals (Sweden)

    Pedro Lira Olmo

    2001-12-01

    Se menciona cada artículo y sus contenidos, mediante un resumen que pretende rescatar sus aspectos sustantivos. Del mismo modo, se destaca en negritas el concepto o idea fuerza de cada punto y se agrega un punto de análisis y comentarios relacionados a los alcances, componentes y competencias que se derivan de su aplicación en cuanto instrumento de Ordenación del Territorio.

  3. Innovación empresarial y territorio: Una aplicación a Vigo y su área de influencia

    Directory of Open Access Journals (Sweden)

    Carlos María Jardón

    2011-09-01

    Full Text Available La innovación es la capacidad de generar e incorporar conocimientos para dar respuestas creativas a los problemas del presente. En la situación actual es vista como un factor clave para mejorar la competitividad de las empresas y favorecer el desarrollo sostenible en los territorios. Las pymes tienen una mayor dependencia del territorio, por lo que se analiza cuál es el efecto que la gestión del territorio por parte de las empresas tiene sobre su capacidad de innovación. Se evalúa el sistema de innovación de las pymes de Vigo y su área de influencia. A partir de una encuesta entre las pymes de las diferentes cadenas empresariales existentes en la zona y mediante el uso de la técnica de mínimos cuadrados parciales (PLS se muestra que los factores externos asociados a ese territorio tienen un impacto importante sobre los factores internos asociados a la capacidad de innovación de la empresa.Innovation is the ability to generate and integrate knowledge to provide creative answers to current problems. In the current situation it is seen as a key factor to improve the competitiveness of companies and to promote sustainable development in territories. SMEs are more dependent to the territory. This essay discuss the effect of land management by companies has on their ability to innovate. It assesses the innovation system of SMEs in Vigo and its surrounding area. From a survey of SMEs in the various existing business clusters in the area and using the technique of partial least squares (PLS it shows that externalities associated with that territory have a major impact on the internal factors associated the innovativeness of the company.

  4. Lectura del desplazamiento forzoso por la violencia en Colombia desde el territorio y las condiciones habitacionales. El caso de estudio de Bogotá

    OpenAIRE

    Burbano González, David

    2014-01-01

    La tesis presenta el resultado de la investigación sobre la lectura histórica, territorial y espacial del problema del desplazamiento forzado por la violencia en Colombia asociado en particular a las condiciones del desplazado en Bogotá. Para ello el problema del desplazamiento se asume desde la perspectiva de los procesos migratorios como un proceso emergente asociado al impacto que tiene sobre el territorio rural colombiano, las regiones urbanizadas y las grandes ciudades como principales r...

  5. Il nuovo server per il calcolo parallelo al CILEA: HP 9000 Enterprise Server K580

    OpenAIRE

    Bonini, Francesca

    1999-01-01

    In questo articolo è presentato il nuovo server ad alte prestazioni, per il calcolo parallelo, disponibile al Cilea. In particolare, viene fornita una breve descrizione dei pacchetti software disponibili, della configurazione e delle modalità di utilizzo della macchina.

  6. Contribuciones para la reflexión: Conflictos ambientales y territorio. En la búsqueda de una complementariedad teórico-conceptual

    Directory of Open Access Journals (Sweden)

    Virginia Toledo López

    2011-12-01

    Full Text Available El artículo procura dar cuenta de las contribuciones del enfoque geográfico en general y del concepto de “territorio”, en particular, en relación al estudio de los conflictos ambientales. Ello se realiza a través de un desarrollo teórico-conceptual que permite delimitar la esfera de significado de estos conceptos. Enunciando primeramente cómo son entendidos los conflictos ambientales desde la Ecología Política, luego se define el espacio, el espacio geográfico y el territorio, para luego ejercitar su interrelación. Se concluye que es posible encontrar fuertes puntos de diálogo entre el territorio en tanto concepto geográfico y el abordaje de los conflictos ambientales aquí desarrollado. Se considera por lo tanto que el análisis de la dinámica que adquiere el territorio constituye un punto de partida ineludible para la comprensión de la complejidad inherente a la conflictividad ambiental.

  7. Tensiones entre el relato historiográfico y lo político: el caso del Territorio Nacional de Chubut (1954-1955

    Directory of Open Access Journals (Sweden)

    Anaclara Raffaele

    2012-12-01

    Full Text Available Los territorios nacionales constituyeron durante 70 años unidades político-administrativas que no gozaron de los derechos políticos que poseían para ese entonces el resto de las provincias argentinas. Los territorios patagónicos sufrieron especialmente el aislamiento que esta situación conllevaba, construyéndose en torno a éstos un discurso acerca de su inmadurez política y social. El presente trabajo propone una reflexión acerca de los modos en que este proceso ha sido conceptualizado por la historiografía. A partir del estudio del proceso de provincialización del Territorio Nacional de Chubut intentaremos aportar nuevas herramientas de análisis que nos permitan indagar acerca de las especificidades de los discursos que dieron forma a una realidad política particular a través de un enfoque que priorice la contingencia y dinamismo de las relaciones políticas.

  8. Los espacios naturales protegidos como categoría en la ordenación del territorio. El caso de la comunidad autónoma andaluza

    Directory of Open Access Journals (Sweden)

    M.ª Luisa Gómez Moreno

    2010-01-01

    Full Text Available Se analiza la incidencia de la declaración de espacios naturales protegidos en la ordenación del territorio de la comunidad autónoma andaluza según las siguientes líneas: 1.-Origen; 2.-La relación con elementos del territorio andaluz; 3.-Aportaciones de su gestión a la ordenación del territorio y a las políticas sectoriales correspondientes a medio ambiente y desarrollo rural; 4.-Las perspectivas que abre el cambio de legislación introducido por la Ley 42/2007. Los resultados de este análisis ponen de manifiesto que la lógica de la función de los espacios naturales protegidos en Andalucía responde a una escala de comunidad autónoma en cuanto a objetivos de planificación sectorial enfocada a la conservación de los factores bióticos y abióticos y al suministro de bienes ambientales y a una escala municipal respecto a la planificación urbana pero desatiende de facto objetivos de planificación sectorial destinada al desarrollo rural de escala municipal supramunicipal.

  9. Eccrine sweat contains IL-1α, IL-1β and IL-31 and activates epidermal keratinocytes as a danger signal.

    Directory of Open Access Journals (Sweden)

    Xiuju Dai

    Full Text Available Eccrine sweat is secreted onto the skin's surface and is not harmful to normal skin, but can exacerbate eczematous lesions in atopic dermatitis. Although eccrine sweat contains a number of minerals, proteins, and proteolytic enzymes, how it causes skin inflammation is not clear. We hypothesized that it stimulates keratinocytes directly, as a danger signal. Eccrine sweat was collected from the arms of healthy volunteers after exercise, and levels of proinflammatory cytokines in the sweat were quantified by ELISA. We detected the presence of IL-1α, IL-1β, and high levels of IL-31 in sweat samples. To investigate whether sweat activates keratinocytes, normal human keratinocytes were stimulated with concentrated sweat. Western blot analysis demonstrated the activation of NF-κB, ERK, and JNK signaling in sweat-stimulated keratinocytes. Real-time PCR using total RNA and ELISA analysis of supernatants showed the upregulation of IL-8 and IL-1β by sweat. Furthermore, pretreatment with IL-1R antagonist blocked sweat-stimulated cytokine production and signal activation, indicating that bioactive IL-1 is a major factor in the activation of keratinocytes by sweat. Moreover, IL-31 seems to be another sweat stimulator that activates keratinocytes to produce inflammatory cytokine, CCL2. Sweat is secreted onto the skin's surface and does not come into contact with keratinocytes in normal skin. However, in skin with a defective cutaneous barrier, such as atopic dermatitis-affected skin, sweat cytokines can directly act on epidermal keratinocytes, resulting in their activation. In conclusion, eccrine sweat contains proinflammatory cytokines, IL-1 and IL-31, and activates epidermal keratinocytes as a danger signal.

  10. Level Of Cytokines (Like IL-1 , IL-6 , IL-8 And TNF-  In Platelet Concentrates

    Directory of Open Access Journals (Sweden)

    Shayegan M

    2004-09-01

    Full Text Available Background: As increase of cytokines (like IL-1 , IL-6 , IL-8 and TNF-  in platelet concentrates (PCs during storage are involved in Febrile Non Hemolytic Transfusion Reactions (FNHTRs after Platelet transfusion, the aim of this study was the survey of these cytokines level in PCs produced in Tehran Blood Center. Materials and Methods: This study proposed to determine if WBC reduction in PCs by pre-storage leuckodepletion filters reduced the levels of these cytokines during storage uo 3 days. Each of the PCs (n = 54 was prepared from single random donor (RD by Platelet-Rich-Plasma (PRP, then were divided in four groups: 1- unfiltered non-irradiated RD-PCs (n= 13 2- unfiltered and -irradiated RD-PCs (n=16 3 - filtered non-irradiated RD-PCs (n=14 4-filtered and -irradiated RD-PCs (n = 11. Cytokines levels in PCs supernatants were measured by ELISA kits according manufacture‘s instructions. Results: Our results showed : IL-8 was increased in unfiltered non-irradiated and IL-18 in -irradiated RD-PCs but not in the filtered RD-PCs in day 3 . Compared to unfiltered PCs in filtered units, pre-storage filtration prevented a rise in the IL-8 and TNF-  in day 3 of storage .The concentration of IL-1 was lower than the minimal detectable concentration by the kits used for this purpose. IL-6 was detected only in 7 units of all filtered PCs in day 3. Conclusion: These data indicate that pre-storage leuko-reduction of PCs can prevent accumulation of IL-6, IL-8 and TNF-  during storage.

  11. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.

    LENUS (Irish Health Repository)

    Reeves, Emer P

    2010-02-01

    Dysregulation of airway inflammation contributes to lung disease in cystic fibrosis (CF). Inflammation is mediated by inflammatory cytokines, including IL-8, which illustrates an increase in biological half-life and proinflammatory activity when bound to glycosaminoglycans (GAGs). The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF. Bronchoalveolar lavage fluid was collected from patients with CF (n = 28), non-CF controls (n = 14), and patients with chronic obstructive pulmonary disease (n = 12). Increased levels of IL-8 and reduced concentrations of IL-18 were detected in bronchial samples obtained from CF individuals. The low level of IL-18 was not a defect in IL-18 production, as the pro- and mature forms of the molecule were expressed and produced by CF epithelial cells and monocytes. There was, however, a marked competition between IL-8 and IL-18 for binding to GAGs. A pronounced loss of IL-18 binding capacity occurred in the presence of IL-8, which displaced IL-18 from these anionic-matrices, rendering the cytokine susceptible to proteolytic degradation by neutrophil elastase. As a biological consequence of IL-18 degradation, reduced levels of IL-2 were secreted by Jurkat T lymphocytes. In conclusion, a novel mechanism has been identified highlighting the potential of IL-8 to determine the fate of other inflammatory molecules, such as IL-18, within the inflammatory milieu of the CF lung.

  12. Endogenous suppression of mast cell development and survival by IL-4 and IL-10.

    Science.gov (United States)

    Speiran, Kelly; Bailey, Daniel P; Fernando, Josephine; Macey, Matthew; Barnstein, Brian; Kolawole, Motunrayo; Curley, Dana; Watowich, Stephanie S; Murray, Peter J; Oskeritzian, Carole; Ryan, John J

    2009-05-01

    Mast cell development is an important component of atopic and chronic inflammatory diseases such as asthma, multiple sclerosis, rheumatoid arthritis, and atherosclerosis. In this study, we found that IL-4 and IL-10 were produced constitutively in cultures of developing mast cells, correlating with mast cell purity. Deletion of either gene increased mast cell numbers and Fc epsilon RI expression during culture in IL-3 + stem cell factor (SCF). By adding exogenous IL-4 and IL-10 to bone marrow (BM) cultures containing IL-3 + SCF, we found that IL-4 + IL-10 suppressed mast cell development through mechanisms not used by either cytokine alone. IL-4 + IL-10 elicited a rapid cell death coincidental with reduced Kit receptor expression and signaling and enhanced mitochondrial damage and caspase activation. IL-4 or IL-10 costimulation, unlike either cytokine alone, altered mast cell ontogeny to yield predominantly macrophages in cultures that typically produce mast cells. This effect was observed consistently with unseparated BM cells, purified mouse BM stem cells, and erythrocyte-depleted human umbilical cord blood cells. These experiments demonstrated a major role for Stat6 and Stat3, but not the Stat3-induced transcriptional repressor Ets variant gene 3. Genetic background was also a critical factor, as BALB/c-derived BM cells were completely resistant to IL-10-mediated killing and expressed lower levels of IL-10R. Collectively, these results support the theory that IL-4 and IL-10 function as endogenous regulators of mast cell progenitor development, consistent with a role in immune homeostasis. Loss of this homeostasis, perhaps via genetic polymorphism, could contribute to the etiology of mast cell-associated disease.

  13. The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    Isabela Siloşi

    2016-01-01

    Full Text Available Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA, the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of the utility of IL-13 and -17 concentration measurements as markers of disease activity. Materials and Methods. Serum samples were collected from 30 patients and from 28 controls and analysed parameters. Results. The serum concentrations of IL-13, IL-17, anti-CCP, and IgM-RF were statistically significantly higher in patients with eRA, compared to the controls. IL-13 concentrations in the severe and moderate groups with eRA were statistically higher than in the mild and control groups. Also, in the case of IL-17, serum concentrations increased proportionally with the disease activity of eRA. We observe that concentrations of IL-13 and -17 did not correlate with autoantibodies. IL-17 concentration significantly positively correlated with CRP, while IL-13 concentration significantly negatively correlated with CRP. Disease activity score, DAS28, was strongly positively correlated with levels of ESR and weakly positively correlated with concentrations of anti-RA33 autoantibodies. IL-13 has a higher diagnostic utility than IL-17, CRP, ESR, IgM-RF, and anti-CCP as markers of disease activity. Conclusions. The presence of higher IL-13 and IL-17 serum levels in patients, compared with those of controls, confirms that these markers, found with high specificity, might be involved in the pathogenesis of eRA. IL-13 and IL-17 might be of better usefulness in the prediction of eRA activity status than IgM-RF and anti-CCP.

  14. Indagini Stratigrafiche e Sistemi Informativi Architettonici: il GIS della chiesa di S. Maria in Valle Porclaneta

    Directory of Open Access Journals (Sweden)

    Trizio, Ilaria

    2009-12-01

    Full Text Available The church of Santa Maria in Valle Porclaneta and its accessories are what remains of an ancient Benedictine monastery, built in the heart of Abruzzo region (Magliano dei Marsi, L’Aquila at the end of the XII century. Even if literature, starting from the end of XIX century, has been often interested in this architectural manufactured, the process of historical-critical knowledge of the complex revealed itself difficult due to the absence of archaeological data, the shortage of the documents and, above all, the numerous interventions of restoration that, followed during all last century, have deeply modified the original compages of it. Due to the difficulties met, the overlap between the few documental data and the data derived from the direct investigation of the structures, performed with the aid of an Architectural Informative System, made possible to hypothesize a chronological reconstruction of the principal phases of life of the monastic complex.[it] La chiesa di Santa Maria in Valle Porclaneta e i suoi ambienti accessori sono quanto resta di un antico monastero benedettino, edificato nel cuore del territorio abruzzese (Magliano dei Marsi, L’Aquila sul finire del XII secolo. Sebbene la letteratura, a partire dalla fine dell’Ottocento, si sia spesso occupata di questo manufatto, il processo di conoscenza storico-critica del complesso si è rivelato difficoltoso a causa dell’assenza di dati archeologici, della scarsità di fonti documentarie pervenute, e, soprattutto a causa del susseguirsi di numerosi interventi di restauro che, succedutisi senza soluzione di continuità per tutto il secolo scorso, ne hanno letteralmente stravolto la compagine originale. A fronte delle difficoltà incontrate, la sovrapposizione tra i pochi dati documentali e i dati derivati dall’indagine diretta delle strutture, eseguita con l’ausilio di un Sistema Informativo Architettonico ha consentito di ipotizzare una ricostruzione cronologica delle

  15. Estudio de la marcha interanual de la frecuencia de ocurrencia de observaciones con tormenta para el territorio cubano

    Directory of Open Access Journals (Sweden)

    Lourdes Álvarez Escudero

    2012-03-01

    Full Text Available Usando como información de base los registros de observaciones trihorarias de código de estado del tiempo pre- sente para 69 estaciones del territorio cubano, se realiza un análisis de la calidad de la información teniendo en cuenta fundamentalmente cuan completas se encontraban las series de registros. El 98 % de las estaciones califican sus series como buenas o categorías superiores y el calificador que acumula más series con resultados regulares y malos es el sesgo horario. Se determinó que el periodo 1989-2008 era el más idóneo para el estudio y se selecciona- ron las observaciones relativas al fenómeno "tormenta eléctrica". Se realizó un estudio de marcha interanual de la frecuencia de ocurrencia de observaciones con tormentas, que mostró una mayoría de series con comportamiento diverso, ya sea homogéneo o tendencia creciente o decreciente y su disposición espacial no mostró áreas de pauta preferente.

  16. Expansión del rango de la Paloma Coroniblanca Columba leucocephala al territorio continental de Colombia

    Directory of Open Access Journals (Sweden)

    Moreno José Gregorio

    1999-06-01

    Full Text Available Entre las 32 especies de la familia Columbidae anotadas para Colombia, Hilty & Brown (1986 incluyeron a la Paloma Coroniblanca Columba leucocephala L. como restringida al archipiélago de San Andrés y Providencia. Esta especie, de amplia distribución en las Antillas, ha sido registrada en algunas islas continentales o localidades costeras en el sur de la Florida, Costa Rica y Panamá (Bond 1950, 1961, Wetmore 1968, Stiles & Skutch 1989. En Colombia C leucocephala fue encontrada en las islas de San Bernardo, a menos de 30 km del litoral Caribe del Departamento de Sucre (9° 40'Norte, 75° 45'Oeste en 1980 y 1981 por Moreno & López (1982, hallazgo que no fue reseñado en la literatura ornitológica de amplia circulación. En esta nota formalizamos la ampliación del rango geográfico de esta especie al territorio continental colombiano, agregando registros adicionales recientes.

  17. Sobre los orígenes de la sociedad asturleonesa: aportaciones desde la arqueología del territorio

    Directory of Open Access Journals (Sweden)

    José Avelino GUTIÉRREZ GONZÁLEZ

    2009-12-01

    Full Text Available RESUMEN: El objetivo de este trabajo es presentar nuevas vías de análisis históricoarqueológicos sobre la transición del mundo antiguo al feudalismo en el norte peninsular basadas en la evolución y transformación de los patrones de asentamiento y modelos de ocupación y explotación del territorio, así como sobre las relaciones de jerarquización entre los asentamientos desde los periodos anteriores (prerromano, romano y especialmente tardoantiguo como forma de entender y explicar la génesis de la organización social feudal.ABSTRACT: The aim of this paper is to present new historical—archaeological analyses of the transition from Antiquity to Feudalism and the origin of Feudal Society in the North of the Iberian Peninsula. The new perspective offered is based on the evolution of settlement patterns and occupation and exploitation models in the territory, as well as in the hierarchical relationships among the settlements from previous periods (pre—roman, roman and, especially, Late Antiquity. All in all, the article offers a new way to understand and explain the origin of the organisation of Feudal Society.

  18. Territorios en perspectiva. La influencia de la distancia fotográfica en algunas interpretaciones americanas del paisaje

    Directory of Open Access Journals (Sweden)

    Carlos Santamarina-Macho

    2016-10-01

    Full Text Available La imagen fotográfica constituye hoy en día una herramienta esencial para el conocimiento, análisis y planificación del territorio, reforzada por su creciente disponibilidad. Sin embargo la fotografía, bajo su apariencia documental, no ofrece información pura de la realidad espacial, sino un relato parcial, seleccionado y codificado de la misma. El uso de imágenes, o de un tipo de imagen, constituye no solo un acto de filtrado de la información, sino también de elección de un modo determinado de interpretarla. Este artículo analiza comparadamente un conjunto de modos de entender el paisaje, tanto el natural como el alterado por la acción humana, que se desarrollaron en los Estados Unidos durante las décadas posteriores a la Segunda Guerra Mundial, y del uso que los mismos realizan de determinados tipos de representaciones fotográficas, particularmente de la fotografía aérea, tanto para la comunicación de ideas territoriales como para establecer distancias frente a otras posiciones intelectualmente confrontadas.

  19. Agricultura, invención de un territorio y conservación “etnosférica”

    Directory of Open Access Journals (Sweden)

    Fabio Aldemar Gómez Sierra

    2010-10-01

    Full Text Available Este escrito deriva de un proceso de investigación acerca de los cambios de las sociedades campesinas boyacenses, es un estudio de caso relacionado con la incorporación de la vitivinicultura en las tradiciones agrícolas regionales. La movilidad del concepto territorio entendido como clima, suelo-subsuelo y cultura, fortalecido por la información y la globalización, es comparable con el término etnósfera o sistema de patrimonios comunitarios campesinos que exigen reconocimiento y protección. La incorporación de la viticulturaen las tradiciones agrícolas de Boyacá, deja percibir la emergencia de la transformación permanente del concepto referido, por cuanto presiona instituciones, exige información y revisa la tradición: las denominaciones de origen, aplicadas a la agricultura campesina son repertorios para alcanzar oportunidades políticas, mientras que el aumento en el consumo de vino significa popularización de las élites.

  20. IL-2 loaded dextran microspheres with attractive histocompatibility properties for local IL-2 cancer therapy

    NARCIS (Netherlands)

    Koten, JW; Van Luyn, MJA; Cade, JA; Hennink, WE; Bijleveld, C; Den Otter, W

    2003-01-01

    Biodegradable dextran microspheres (MS) were developed as a slow-release system for interleukin-2 (IL-2) to apply them for local IL-2 therapy of cancer. We describe the tissue reactions induced by these MS without or with IL-2 in rats. Dextran MS stain bright red-purple with the periodic acid Schiff

  1. [Correlation of serum IL-16, IL-18 levels and immunoglobulins in children with asthma].

    Science.gov (United States)

    Xue, Yi-Nan; Zou, Xian-De; Wu, Jia-Ling

    2006-02-01

    This study examined the changes of serum levels of interleukin (IL)-16, IL-18 and immunoglobulins and the correlation of serum IL-16, IL-18 levels and immunoglobulins in children with asthma and aimed to explore the role of IL-16, IL-18 and immunoglobulins in the pathogenesis of asthma. Thirty-four children with asthma and 21 age and gender-matched healthy children were enrolled in this study. The levels of IL-16, IL-18 and immunoglobulin E (IgE) were determined using ELISA. Immunoglobulin G (IgG), immunoglobulin M (IgM) and immunoglobulin A (IgA) were detected by immunoturbidimetry. The levels of IL-16, IL-18 and IgE in patients with asthma at both acute attack and convalescence stages were significantly higher than those in healthy controls. An increased IgG and a decreased IgA levels were found in asthmatic patients at the acute attack stage. There was a positive correlation between the IL-16 and IL-18 levels at both acute attack and convalescence stages of asthma (r=0.70, P attack stage of asthma (r=0.624, P asthma. The immunologic imbalance exists in children with asthma at both acute attack and convalescence stages. Anti-allergic therapy should be administered through the acute attack to the convalescence stages of asthma.

  2. Serum IL17 and IL4R RS1805010 genotypes: relationship with ...

    African Journals Online (AJOL)

    Egyptian Journal of Biochemistry and Molecular Biology ... The current study aimed to assess serum IL17 level in Egyptian patients with RA according toIL4Rrs1805010 genotypes,and to detect possibleassociations ... Meanwhile, serum IL17 levels and Larsen score had significant positive correlation only in GG patients.

  3. Knocking out IL-6 by vaccination

    DEFF Research Database (Denmark)

    Galle, Pia; Hougs, Lotte; Barington, Torben

    2004-01-01

    Inappropriate expression of IL-6 plays a role in various inflammatory conditions, degenerative diseases, and cancers. Several model systems have been developed that can specifically block IL-6-receptor interactions. Here we present a simple and highly effective approach based on vaccination...

  4. Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure.

    Science.gov (United States)

    Liu, Changbo; Li, Mu; Cao, Shixiong; Wang, Jianzhong; Huang, Xiaoqiong; Zhong, Weizhen

    2017-10-01

    The aim of the study was to investigate the effects of high-volume continuous renal replacement therapy (HV-CRRT) on procalcitonin (PCT), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-8 and IL-10 in acute pancreatitis complicated by acute renal failure. Eighty-six patients with acute pancreatitis complicated with acute renal failure were selected from September 2014 to September 2016 in our hospital, and were treated by continuous veno-venous hemofiltration (CVVH). The patients were randomly divided into the observation group, treated by the HV-CVVH model with a displacement rate of 4 l/h, and the control group, treated by the normal capacity model with a displacement rate of 2 l/h. The levels of PCT, TNF-α, IL-4, IL-6, IL-8, and IL-10 in serum were measured by ELISA before and 2, 6 and 12 h after treatment, and 12 h after CVVH. The serum PCT and TNF-α levels in the two groups were decreased at 2 h after treatment. The lowest levels appeared at 6 h after treatment, and then recovered, but remained lower than those before treatment (ptreatment, and the decreases in the observation group were more obvious than those in the control group (ptreatment of pancreatitis complicated by acute renal failure. Additionally, replacement of the blood filter at appropriate time-points can improve the treatment efficacy.

  5. MIGRACIÓN TRABAJADORES RURALES Y CONSTRUCCIÓN SOCIAL DEL TERRITORIO EN EL ALTO VALLE DE RÍO NEGRO

    Directory of Open Access Journals (Sweden)

    Martha Radonich

    2008-12-01

    Full Text Available El espacio del Alto Valle del río Negro históricamente expresó la tensión global–local, dado que desde principios del siglo XX, la actividad frutícola se orientó a la exportación. Esto generó dinámicos flujos de capital, de mercancías y de trabajadores rurales. Al consolidarse esta producción se afianzaron las “chacras” como unidades productivas dominantes, al tiempo que en sus “márgenes” se formaron pequeños núcleos de población trabajadora. Estos territorios, próximos a las explotaciones, a orillas de los canales de riego -calles ciegas- o como barrios marginales de la zona urbana, constituyeron un patrón de organización espacial con características particulares. Los mismos se originaron por la radicación de familias de migrantes, en su mayoría chilenos que venían a levantar la cosecha y que finalmente se establecieron en la zona. Estos espacios residenciales conviven con las organizaciones productivas mayores, en las cuales se emplean. Territorializarse, para muchos migrantes y sus familias, significó crear prácticas que les proporcionan efectivo “poder” sobre su reproducción en cuanto grupos sociales. La imbricación en la larga duración de estos territorios relacionados con la migración y el trabajo en la fruticultura, permite mostrar la complementariedad de territorios para producción y territorios para la reproducción. Desde la visión de una construcción social del territorio se reconoce la importancia del proceso social de producción protagonizado por el trabajo. El abordaje de la temática combina metodologías cuantitativas y cualitativas, procedimientos histórico-comparativo, estadístico-geográfico y estudio de caso, asimismo se triangulan fuentes primarias y secundarias.

  6. Architettura dell'insediamento e infrastrutture. Il paesaggio siciliano tra Palermo e Agrigento / Architecture of the settlement and infrastructures. Sicilian landscapes between Palermo and Agrigento

    Directory of Open Access Journals (Sweden)

    Antonino Margagliotta

    2013-07-01

    Full Text Available La piena consapevolezza della modernità impone oggi di interrogarsi sulla nuova natura morfologica e dimensionale dei luoghi, per comprenderne il senso delle relazioni spaziali e tentarne un’elaborazione estetica. Il tema è stato sviluppato nell’ambito del paesaggio siciliano, in particolare, nel sistema definito da un attraversamento interno della Sicilia: la strada che, congiungendo Palermo con Agrigento, collega il mar Tirreno al Mare Africano, definisce una fascia territoriale ben identificabile in cui si manifesta una molteplicità di condizioni. Si elabora, in tal modo, un quadro interpretativo e progettuale all’interno di un vasto territorio contrassegnato dalla presenza di piccoli centri urbani che interferiscono con la rete delle infrastrutture, da spazi di valore naturalistico, dalla campagna agricola e dagli insediamenti rurali, dalle aree industriali (attive e dimesse, dai luoghi ibridi della città diffusa. Il progetto di architettura viene assunto, quindi, per definire e indicare nuove strategie di sviluppo per questo territorio, oltre che per supportare e verificare il pensiero teorico sullo stato presente e sul destino dei luoghi. / Today the full awareness of modernity imposes to question about the new morphological and dimensional nature of the places in order to understand the sense of the spatial relations and to try an aesthetic elaboration of them. The theme has been developed in range of the Sicilian landscape and in particular in the system defined by an inner crossing of Sicily: the road that, joining Palermo and Agrigento, connects the Tyrrhenian sea to the African one and defines a land zone that is well-recognizable, where a multiplicity of conditions arises. In this way we have developed an interpretative and planning picture within an extended area marked by the presence of small urban centers which interfere with the network of infrastructures, by spaces of naturalist value, by the agricultural country and

  7. Monoclonal Antibodies Against IL-13 and IL-31RA in Development for Atopic Dermatitis

    DEFF Research Database (Denmark)

    Hamann, Carsten R; Thyssen, Jacob P

    2017-01-01

    phase two trial has been completed for a humanized antibody against IL-31 receptor alpha, one subunit of the IL-31 receptor complex. This study showed significant dose-dependent reductions in pruritus, EASI scores, and markers of sleep quality. Initial clinical trials for monoclonal antibodies against......The IL-13 and IL-31 cytokines and inflammatory pathways have been identified as important for atopic dermatitis (AD) pathophysiology. Monoclonal antibodies against IL-13 have been studied for the treatment of asthma since 2011. More recently, two phase two trials have been completed...

  8. IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival.

    Science.gov (United States)

    Webster, K E; Kim, H-O; Kyparissoudis, K; Corpuz, T M; Pinget, G V; Uldrich, A P; Brink, R; Belz, G T; Cho, J-H; Godfrey, D I; Sprent, J

    2014-09-01

    Natural killer T (NKT) cells are innate-like T cells that rapidly recognize pathogens and produce cytokines that shape the ensuing immune response. IL-17-producing NKT cells are enriched in barrier tissues, such as the lung, skin, and peripheral lymph nodes, and the factors that maintain this population in the periphery have not been elucidated. Here we show that NKT17 cells deviate from other NKT cells in their survival requirements. In contrast to conventional NKT cells that are maintained by IL-15, RORγt(+) NKT cells are IL-15 independent and instead rely completely on IL-7. IL-7 initiates a T-cell receptor-independent (TCR-independent) expansion of NKT17 cells, thus supporting their homeostasis. Without IL-7, survival is dramatically impaired, yet residual cells remain lineage committed with no downregulation of RORγt evident. Their preferential response to IL-7 does not reflect enhanced signaling through STAT proteins, but instead is modulated via the PI3K/AKT/mTOR signaling pathway. The ability to compete for IL-7 is dependent on high-density IL-7 receptor expression, which would promote uptake of low levels of IL-7 produced in the non-lymphoid sites of lung and skin. This dependence on IL-7 is also reported for RORγt(+) innate lymphoid cells and CD4(+) Th17 cells, and suggests common survival requirements for functionally similar cells.

  9. Los factores del medio físico en el desarrollo de los territorios

    Directory of Open Access Journals (Sweden)

    Salvador, Regina

    2005-12-01

    o A.D. Mellinger confirman que el clima y la distribución de recursos naturales son muy importantes en el crecimiento económico y desarrollo de los países. Las interpretaciones de las relaciones entre el medio y el hombre bajeadas en "paradigmas" (determinismo, posibilismo... deben ser superadas, de una vez por todas, por el discurso geográfico. Se trata de una aproximación útil desde el punto de vista didáctico, pero que esquematiza, en exceso, el pensamiento geográfico. La reflexión geográfica debe superar este esquematismo de los paradigmas y centrarse en la esencial: la interpretación de las relaciones entre el medio y el hombre al largo de la Historia, que es siempre una interpretación sin rupturas. [fr] Pendant des années on a considéré les éléments de la Géographie Physique comme déterminants dans la formation du «caractère» et des spécificités particulières de chaque peuple, ce qui a été appelé de Déterminisme Géographique. A la fin du XIX Siècle, on a commencé à comprendre que l'environnement n'avait pas une relation nécessaire et fataliste avec le développement, c'était seulement une contingence. Ainsi le Possibilisme Géographique est né comme l'ensemble des possibilités qui permettent de ne pas réagir nécessairement de la même façon dans environnements semblables, dû à sa culture et à ses techniques. Malgré cela, des études récentes d'auteurs comme Jeffrey Sachs, J. Gallup ou A.D. Mellinger viennent confirmer que le climat et la distribution des ressources naturelles sont très importants pour l'explication de la croissance économique et le développement des pays. Les interprétations des relations entre l'environnement et l'homme basées dans paradigmes (déterminisme, possibilisme, ... doivent être surmontées, d'une fois pour toutes, par le discours géographique. Il s'agit d'une approche utile du point de vue didactique, mais que schématise en excès la pensée géographique. La réflexion g

  10. IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain.

    Science.gov (United States)

    Wang, H Y; Paul, W E; Keegan, A D

    1996-02-01

    IL-4 binds to a cell surface receptor complex that consists of the IL-4 binding protein (IL-4R alpha) and the gamma chain of the IL-2 receptor complex (gamma c). The receptors for IL-4 and IL-2 have several features in common; both use the gamma c as a receptor component, and both activate the Janus kinases JAK-1 and JAK-3. In spite of these similarities, IL-4 evokes specific responses, including the tyrosine phosphorylation of 4PS/IRS-2 and the induction of CD23. To determine whether sequences within the cytoplasmic domain of the IL-4R alpha specify these IL-4-specific responses, we transplanted the insulin IL-4 receptor motif (I4R motif) of the huIL-4R alpha to the cytoplasmic domain of a truncated IL-2R beta. In addition, we transplanted a region that contains peptide sequences shown to block Stat6 binding to DNA. We analyzed the ability of cells expressing these IL-2R-IL-4R chimeric constructs to respond to IL-2. We found that IL-4 function could be transplanted to the IL-2 receptor by these regions and that proliferative and differentiative functions can be induced by different receptor sequences.

  11. Diagnostic value of combined determination of serum and chest fluid adenosine deaminase (ADA), IL-2, IL-6, IL-10 contents for differentiation of tuberculous from malignant pleural effusion

    International Nuclear Information System (INIS)

    Wu Jiaming; Wang Limin

    2005-01-01

    Objective: To investigate the possible diagnostic value of combined determination of serum and chest fluid contents of ADA, IL-2, IL-6, IL-10 in patients with tuberculous and malignant pleural effusion. Methods: Serum and chest fluid ADA (with biochemical method), IL-2, IL-6, IL-10 (with ELISA) contents were measured in 56 patients with tuberculosis pleural effusion, 53 patients with malignant effusion and 30 controls (in serum only). The receiving operative characteristic (ROC) curve for each parameter was analyzed for study of respective area under curse (Auc). Results: The serum IL-6 levels in both groups of patients were significantly higher than those in the controls (P<0.05). The chest fluid contents of ADA, IL-2, IL-6 and IL-10 in patients with tuberculous effusion were all significantly higher than those in patients with malignancies (P<0.05). The Auc in the ROC was largest in the case of ADA, followed by IL-10, IL-6 with IL-2 the least. Conclusion: Determination of chest fluid ADA, IL-2, IL-6, IL-10 contents was helpful in the differentiation of tuberculous from malignant pleural effusion. Combined determination of chest fluid ADA and IL-10 provided the highest accuracy rate for differentional diagnosis. (authors)

  12. Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma

    Directory of Open Access Journals (Sweden)

    Liat Medina

    2014-01-01

    Full Text Available Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian tissues. Ovarian tissue samples were examined by immunohistochemical staining for IL-18, IL-18BP, and IL-18R and mRNA of these cytokines was analyzed with semiquantitative PT-PCR. IL-18 levels were significantly higher in cancerous ovarian tissues (P=0.0007, IL-18BP levels were significantly higher in normal ovarian tissues (P=0.04, and the ratio of IL-18/IL-18BP was significantly higher in cancerous ovarian tissues (P=0.036. Cancerous ovarian tissues expressed significantly higher IL-18 mRNA levels (P=0.025, while there was no difference in the expression of IL-18BP mRNA and IL-18R mRNA between cancerous and normal ovarian tissues. IL-18 and IL-18BP were expressed dominantly in the epithelial cells of both cancerous and normal ovarian tissues, while IL-18R was expressed dominantly in the epithelial cells of cancerous ovarian tissues but expressed similarly in the epithelial and stromal cells of normal cancerous tissues. This study indicates a possible role of IL-18, IL-18BP, and IL-18R in the pathogenesis of epithelial ovarian carcinoma.

  13. Protection from RNA and DNA viruses by IL-32.

    NARCIS (Netherlands)

    Zepp, J.A.; Nold-Petry, C.A.; Dinarello, C.A.; Nold, M.F.

    2011-01-01

    Several studies have documented a proinflammatory role for IL-32, which induces IL-1alpha, IL-1beta, IL-6, TNF, and chemokines via NF-kappaB, p38MAPK, and AP-1. However, IL-32 also participates in the responses to infection with viruses such as HIV-1 and influenza. In this study, we explored these

  14. Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35

    Directory of Open Access Journals (Sweden)

    P. Bayrak Degirmenci

    2018-01-01

    Full Text Available Background. We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches. Methods. IL-10, IL-17, TGF-β, IFN-γ, IL-22, and IL-35 serum levels of allergic rhinitis (AR patients were measured using ELISA method. Allergic sensitization was demonstrated by the skin prick test. Patients only with olive tree sensitivity were evaluated for seasonal AR (SAR. Patients only with mite sensitivity were included in the study for perennial AR (PAR. AR clinic severity was demonstrated by the nasal symptom scores (NSS. Results. In total, 65 AR patients (patient group, having 31 PAR and 34 SAR patients, and 31 healthy individuals (control group participated in the study. Cytokine levels between the patient group and the control group were compared; IL-17 (p=0.038, IL-22 (p=0.001, and TGF-β (p=0.031 were detected as high in the patient group, and IFN-γ (p<0.001 was detected as low in the patient group. When correlation analysis was made between age, gender, prick test result, NSS, AR duration, and cytokine levels in the patient group, a negative correlation was detected only between IFN-γ (p=0.032/r=−0.266 level and NSS. Conclusions. Accompanied by the literature information, these results made us think that T cell subgroups and cytokines have an important role in AR immunopathogenesis. It is thought that future studies to be conducted relating to this subject will form new targets in treatment.

  15. Google e il patrimonio culturale italiano

    Directory of Open Access Journals (Sweden)

    Elisa Bonacini

    2014-04-01

    Full Text Available ITIn questo lavoro si intende ricostruire il ruolo svolto dal motore di ricerca google nella moderna società culturale e, soprattutto, il ruolo svolto da google nella comunicazione e valorizzazione del patrimonio culturale italiano attraverso il cultural institute e tutti i software e gli applicativi che google mette a disposizione della cultura.ENAim of this paper is the reconstruction of google’s role in modern cultural society and, above all, its role through the google cultural institute and its many softwares and applications, for communication and dissemination of italian cultural heritage.

  16. Un portale webGIS a supporto della viticoltura

    Directory of Open Access Journals (Sweden)

    Luca Delluchi

    2009-03-01

    Full Text Available HarvAssist: a webGIS in support of grape harvesting HarvAssist is a website, created at the Edmund Mach – IASMA Foundation in collaboration with Cavit s.c., which aims to assist the winemakers in choosing the best time for grape harvest. The portal, developed only using open source software, is based on a geospatial database and it presents a simple web interface for managing and displaying the data. Finally a webGIS application allows to view the vineyards on maps, to retrieve the main chemical-analytical data and to receive projections of the ideal time for the harvest.

  17. Infezione da Bartonella henselae: caso clinico e supporto diagnostico

    Directory of Open Access Journals (Sweden)

    Salvatore Nisticò

    2006-03-01

    Full Text Available Cat scratch disease is due to a bacterial infection sustained by Bartonella strains, transmitted to the human through the bite, scratch or lick of cats.We report a case about a young man who showed up to the Pediatrics outpatient clinic after he noticed a growing mass in his left armpit, preceded by malaise, fatigue and mild fever. The detection of the scar as a consequence of a cat scratch suggested the Bartonella infection diagnosis. Thus the patient had a blood test, the erythrocyte sedimentation velocity and specific antibodies assay: the measurement of serum Bartonella specific antibodies yelded high levels of IgM and IgG which confirmed the diagnosis.The patient was treated with a course of oral antibiotic, specifically Claritromicin 250 mg tablets BID for two weeks.After 30 days the axillary nodal mass downsized.The serum immunoglobulin assay cut down the time required for the formulation of the causative diagnosis and allowed for a prompt and aimed antimicrobial therapy. Compared with the blood culture, the antibodies test screening is quicker and highly reliable.

  18. Un portale webGIS a supporto della viticoltura

    Directory of Open Access Journals (Sweden)

    Luca Delluchi

    2009-03-01

    Full Text Available HarvAssist: a webGIS in support of grape harvestingHarvAssist is a website, created at the Edmund Mach – IASMA Foundation in collaboration with Cavit s.c., which aims to assist the winemakers in choosing the best time for grape harvest. The portal, developed only using open source software, is based on a geospatial database and it presents a simple web interface for managing and displaying the data. Finally a webGIS application allows to view the vineyards on maps, to retrieve the main chemical-analytical data and to receive projections of the ideal time for the harvest.

  19. VERSO NUOVI MODELLI DI SUPPORTO ALLE DECISIONI NEL CONTESTO URBANO

    Directory of Open Access Journals (Sweden)

    Sara Torabi Moghadam

    2016-12-01

    Full Text Available The current growth of urbanization rate indicates that this trend is not going to stop, and therefore, it stresses the necessity of actions for mitigating the local and global pollution. Moreover, most of the actual stock is characterized by low energy performances since it pre-dates the energy regulation. The paper aims at addressing this issue by proposing the integration of Building Simulation (BS approach, Multi-Criteria Analysis (MCA methods and Geographic Information System (GIS tool for developing a new Multi-Criteria Spatial Decision Support System (MC-SDSS in urban context. The BS of relevant building archetypes allows to identify different resolutions of energy data: hour-by-hour data can be useful for demand-side management or renewable integration while aggregated data can be used for load forecasting and retrofit simulations. The MCA permits choosing between different building renovation alternatives by considering both qualitative and quantitative criteria. Moreover, the GIS support the method by creating geo-referenced databases. The method purposes in giving a comprehensive view to address the complexity of urban building energy planning; due to its flexibility, it can be applied to several urban areas. Three main phases characterize the study: i. overview of relevant existing techniques; ii. description of the integrated proposed method; iii. discussion and future application. The method can provide relevant feedbacks for ranking complex design energy options.

  20. IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?

    Czech Academy of Sciences Publication Activity Database

    Tomala, Jakub; Kovář, Marek

    2016-01-01

    Roč. 5, č. 3 (2016), e1102829 ISSN 2162-402X R&D Projects: GA ČR GA13-12885S; GA MŠk(CZ) ED1.1.00/02.0109 Institutional support: RVO:61388971 Keywords : Anti-IL-2 mAb * cancer immunotherapy * IL-2 Subject RIV: EE - Microbiology, Virology Impact factor: 7.719, year: 2016

  1. Trabajo, Territorio y Políticas de Empleo. El caso de la Ciudad de Río Cuarto

    Directory of Open Access Journals (Sweden)

    Jorgelina Giayetto

    2016-12-01

    Full Text Available El objetivo general del presente trabajo es explorar el rol que las políticas públicas de empleo tienen en el desempeño del mercado de trabajo local y en la consecución de mayores y mejores condiciones laborales. En este sentido, dos ideas fuerzas orientan la investigación: por un lado, la importancia de recuperar enfoques teóricos alternativos que aporten nuevos elementos para interpretar el mercado de trabajo que se estructura y se comporta de manera compleja y, por otro, la consideración de que los fenómenos socio-económicos no pueden ser comprendidos fuera del espacio geográfico o territorio usado. Para analizar las intervenciones sobre el mercado de trabajo de Río Cuarto se realizaron entrevistas a tres informantes clave que se desempeñaron como responsables de las áreas de empleo en los distintos niveles político-administrativos de gobierno (nacional, provincial y municipal durante el período 2012-2015. Las experiencias de gestión política arrojan luz sobre el modo en que se abordan los problemas del mercado de trabajo a partir del diagnóstico previo de su desempeño, de los problemas que se identifican y definen como prioritarios y de las causas a las que se atribuyen así como de la consideración del modo en que se hace la política, sus condicionamientos y la coordinación de objetivos e intervenciones con otros niveles de gobierno.

  2. La construcción del entorno del Monasterio de San Lorenzo de El Escorial. Agua, territorio y paisaje

    Directory of Open Access Journals (Sweden)

    Chías, P.

    2014-12-01

    Full Text Available Studies about the Monastery of El Escorial focused traditionally on the architectural, formal qualities of the monastic buildings, eluding other essential subjects as the infrastructures. It would have been impossible to develop the daily life wihout them. The needs of the different uses in such a complex ensemble needed a great set of buildings and infrastructures such as water supply and sewage, but also water mills and roads, to access and ensure the provisions. Our research deals with the study of all these hydraulic infrastructures, which were built continuously from the 16th century onwards, not only to serve the monastic buildings, but also the town of San Lorenzo. As complex net of civil works, it introduced in the territory and the landscape an essential set of landmarks, most of which still remain unknown.Los estudios sobre el Monasterio del Escorial se han centrado tradicionalmente en las cualidades arquitectónicas, formales y estilísticas del conjunto, evitando abordar el complejo e imprescindible sistema de infraestructuras construido para su servicio y sin el que no hubiera podido desarrollar las actividades religiosas, formativas y cortesanas para las que fue proyectado. Los requisitos funcionales de un conjunto tan importante hicieron necesaria la construcción de un gran número de obras como el abastecimiento de agua y el saneamiento, pero también ingenios como los molinos o caminos para facilitar el acceso y asegurar su abastecimiento. La presente investigación aborda el estudio de las infraestructuras del agua, construidas ininterrumpidamente desde del siglo XVI para dar servicio en un primer momento al conjunto monacal, y después a la propia población de San Lorenzo. Esta compleja red ha aportado al territorio y al paisaje un formidable conjunto de hitos aún desconocidos en su mayoría

  3. En relación a las vías romanas y mansiones del territorio provincial de Albacete

    Directory of Open Access Journals (Sweden)

    G. Carrasco Serrano

    2000-01-01

    Full Text Available Las fuentes antiguas itinerarias que proporcionan datos sobre las comunicaciones romanas del área geográfica correspondiente al actual territorio provincial de Albacete son, el Itinerario de Antonino, los Vasos de Vlcarello y el Anónimo de Rávena. Pero a estas vías mencionadas en dichas fuentes, habrá que añadir otros trazados no atestiguados en los itinerarios de época clásica, como es el caso de la ruta Corduba-Saguntum, y cuyo estudio arqueológico permitirá Ir completando el sistema de comunicaciones en época romana de este ámbito territorial, cuya situación le convertirá en zona de paso obligado entre la costa, el interior y la alta Andalucía.The sources of oíd itineraríes that provide Information on the Román Communications within the geographical área corresponding today to the province of Albacete are: the Antonino Itinerary, the Vicarello Vases and the Anonymous of Ravena. But apart from the routes mentioned in these sources, there are others not included in the itineraríes of the classic period, such as the Corduba- Saguntum route, an archeological study of which will provide further knowledge of the system of Communications that existed in Román times in this territory, the location of which makes it a natural passage between the coast, inland and upper Andalucía.

  4. ENSAYO: Producción de Vivienda de Interés Social (VIS. Impactos en el territorio

    Directory of Open Access Journals (Sweden)

    Andrea Sarracina

    2015-12-01

    Full Text Available RESUMEN La significativa producción de Viviendas de Interés Social en Argentina en los últimos diez años, muestra el rol que el Estado –mediante las políticas públicas– tiene en el crecimiento y desarrollo territorial. La Política Federal de Vivienda integrada por numerosos programas y operatorias, permite el acceso a la vivienda reconocida como derecho universal por diferentes instrumentos de derechos humanos, además de ser bien material, de consumo y social, ligada a la satisfacción de necesidades básicas y a la calidad de vida de la población. Sin embargo, y a pesar de atender parte de la demanda habitacional, todavía necesita más atención el tema de la planificación y su impacto en el territorio e incluir necesariamente al hábitat como proceso dinámico y complejo, que se logra abordando el tema habitacional de forma integral. ABSTRACT The significant production of Social Interest Housing in Argentina in the last ten years, shows the role that the State -through the public policies- on growth and territorial development. The Federal Housing Policy comprising numerous programs and operative enables access to housing as a universal right recognized by various human rights instruments, in addition to being well Material, consumer and social, linked to meeting basic needs and quality life of the population. However, despite attending part of housing demand, still you need more attention issue of planning and its impact on the territory and necessarily include habitat as a dynamic and complex process, achieved by addressing the housing issue holistically

  5. La “grande bellezza” del paesaggio italiano nel cinema contemporaneo: tra falsificazione e finanziamento locale / The “great beauty” of Italian landscape in contemporary movies: between falsification and local funding

    Directory of Open Access Journals (Sweden)

    Eleonora Mastropietro

    2016-05-01

    Full Text Available I film hanno rappresentato l’evoluzione del paesaggio italiano per gran parte del novecento. Negli ultimi due decenni i film italiani hanno però smesso di esplorare le trasformazioni del territorio. La debolezza dell’industria cinematografica spiega in parte l’assenza del contemporaneo dagli schermi. Inoltre il diffuso ricorso al supporto economico degli enti pubblici, che spesso vedono i film come strumenti di promozione turistica, sembra influenzare le modalità di rappresentazione del paesaggio. Il contributo presenta una ricerca condotta sui film di maggior successo tra il 1990 e il 2014 alla ricerca dell’immagine del paesaggio italiano in essi prevalente e evidenzia alcune cause alla base di questa rappresentazione omogenea. Films have portrayed the evolution of the Italian urban landscape in the last 100 years. Nevertheless, contemporary movies partially ignore the recent transformations and represent instead a stereotyped image of Italian landscapes. The structure of the local movie industry could provide a first explanation of this phenomenon. Moreover, the financial support of productions provided by local government influences the choice of including or excluding elements of the landscape in the movies screen. The paper explores the new representations of landscape in Italian movies, in order to show which features of the changing contemporary Italian landscapes are visible and which are hidden.

  6. The role of interleukin-5 (IL-5 in vivo: studies with IL-5 deficient mice

    Directory of Open Access Journals (Sweden)

    Klaus I Matthaei

    1997-12-01

    Full Text Available Eosinophil recruitment is a characteristic feature of a number of pathological conditions and was the topic of the recent International Symposium on allergic inflammation, asthma, parasitic and infectious diseases (Rio de Janeiro, June 3-5, 1996. Since interleukin5 (IL5 is believed to regulate the growth, differentiation and activation of eosinophils (Coffman et al. 1989, Sanderson 1992, the role of eosinophils and IL5 are closely linked. Although IL5 specifically regulates eosinophilia in vivo and this is its most well established activity, it is becoming clear that IL5 also has other biological effects. The recent derivation of an IL5 deficient mouse (Kopf et al. 1996, provides a model for exploring not only the role of IL5 and eosinophils but also other novel activities of IL5. Of note is that although the IL5 deficient mice cannot elicit a pronounced eosinophilia in response to inflammatory stimulation following aeroallergen challenge or parasite infection they still produce basal levels of eosinophils that appear to be morphologically and functionally normal. However, the basal levels of eosinophils appear insufficient for normal host defence as IL5 deficiency has now been shown to compromise defence against several helminth infections. In addition, IL5 deficient mice appear to have functional deficiencies in B-1 B lymphocytes and in IgA production.

  7. Cytokine vaccination: neutralising IL-1alpha autoantibodies induced by immunisation with homologous IL-1alpha

    DEFF Research Database (Denmark)

    Svenson, M; Hansen, M B; Thomsen, Allan Randrup

    2000-01-01

    High-affinity IgG autoantibodies (aAb) to IL-1alpha are among the most frequently found aAb to cytokines in humans. To establish an animal model with aAb to IL-1alpha, we immunised mice with recombinant murine IL-1alpha. Unprimed and Bacille Calmette-Guérin (BCG)-primed BALB/cA mice were vaccinated...... in mice by vaccination with recombinant murine IL-1alpha conjugated to PPD. Studies of the effects of IL-1alpha aAb in such animals may help clarify the importance of naturally occurring IL-1alpha aAb in humans and permit the evaluation of future therapies with cytokine aAb in patients...... with IL-1alpha coupled to purified protein derivative of tuberculin (PPD). Both unprimed and primed animals developed IgG aAb to IL-1alpha. These aAb persisted at high levels more than 100 days after vaccination and did not cross-react with murine IL-1beta. The induced anti-IL-1alpha aAb inhibited binding...

  8. B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis.

    Science.gov (United States)

    Yilmaz, Vuslat; Oflazer, Piraye; Aysal, Fikret; Parman, Yeşim G; Direskeneli, Haner; Deymeer, Feza; Saruhan-Direskeneli, Güher

    2015-06-01

    B cells from myasthenia gravis (MG) patients with autoantibodies (Aab) against acetylcholine receptor (AChR), muscle-specific kinase (MuSK) or with no detectable Aab were investigated as cytokine producing cells in this study. B cells were evaluated for memory phenotypes and expressions of IL-10, IL-6 and IL-12A. Induced productions of IL-10, IL-6, IL-12p40, TNF-α and LT from isolated B cells in vitro were measured by immunoassays. MG patients receiving immunosuppressive treatment had higher proportions of memory B cells compared with healthy controls and untreated patients. With CD40 stimulation MG patients produced significantly lower levels of IL-10, IL-6. With CD40 and B cell receptor stimulation of B cells, TNF-α production also decreased in addition to these cytokines. The lower levels of these cytokine productions were not related to treatment. Our results confirm a disturbance of B cell subpopulations in MG subgroups on immunosuppressive treatment. B cell derived IL-10, IL-6 and TNF-α are down-regulated in MG, irrespective of different antibody productions. Ineffective cytokine production by B cells may be a susceptibility factor in dysregulation of autoimmune Aab production.

  9. Tecnologia italiana per il vuoto spinto

    CERN Multimedia

    2002-01-01

    "Ancora una volta ad aggiudicarsi un ambito riconoscimento internazionale e' un fisico italiano: Cristoforo Benvenuti ritirera' tra pochi giorni a Denver il premio Gaede-Langmuir che viene assegnato dalla American vacuum society" (1/2 page).

  10. Michel Foucault e il problema della genealogia

    Directory of Open Access Journals (Sweden)

    Enrico Abeni

    2011-01-01

    Full Text Available "Si j'étais prétentieux, je donnerais comme titre général à ce que je fais : généalogie de la morale." Dietro questa affermazione, rilasciata nel contesto colloquiale di un'intervista, è possibile scorgere il segno di una confessione intellettuale e il compendio di un pensiero. In primo luogo, allusivamente, rinvia alla figura di Nietzsche e alla traccia indelebile che il suo pensiero ha lasciato nella filosofia e nella ricerca di Foucault. In secondo luogo, autorizza a osservare nella riflessione foucaultiana la filigrana di quella genealogia che il presente lavoro si propone di affrontare come stile d'interrogazione filosofica.

  11. PER ALDO NOSEDA: IL CRITICO MUSICALE

    Directory of Open Access Journals (Sweden)

    Chiara Fiaccadori

    2014-03-01

    Full Text Available Il presente articolo è un tentativo di fornire la lista completa degli scritti di Aldo Noseda (Milano, 1853-Stresa, 1916 come critico musicale. Fu un erudito conoscitore d’arte e appassionato collezionista, ma la quasi totalità dei suoi scritti sono dedicati alla scena musicale italiana. Prese parte all’infiammato dibattito a proposito della musica strumentale divenendo membro della Società del Quartetto e fondando la Società orchestrale della Scala a Milano. Dal 1876 al 1894, sotto lo pseudonimo de Il Misovulgo fu tra gli editorialisti militanti di importanti periodici come «La Gazzetta musicale di Milano», il «Corriere della Sera» e «Il Caffè», contribuendovi con una serie di appassionate recensioni dei contemporanei eventi musicali milanesi.

  12. Il viaggio gastronomico di Paolo Monelli

    Directory of Open Access Journals (Sweden)

    Alberto Salarelli

    2013-01-01

    Full Text Available Il ghiottone errante di Paolo Monelli, pubblicato nel 1935, rappresenta uno dei primi esempi di narrativa di viaggio in tema di enogastronomia, un genere destinato a grande successo nel secondo dopoguerra. In questo articolo, oltre a ripercorrere la vicenda biografica di Monelli, si sottolineano le relazioni tra Il ghiottone e la cultura gastronomica del regime fascista, e si evidenziano alcuni tratti caratteristici del suo stile di scrittura.

  13. Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and Il-15Ralfa-Fc chimera

    Czech Academy of Sciences Publication Activity Database

    Votavová, Petra; Tomala, Jakub; Kovář, Marek

    2014-01-01

    Roč. 195, č. 1 (2014), s. 1-10 ISSN 0165-2478 R&D Projects: GA ČR GAP301/11/0325; GA MŠk(CZ) ED1.1.00/02.0109; GA ČR GA13-12885S Institutional support: RVO:61388971 Keywords : IL-2 * IL-15 * chimera Subject RIV: EC - Immunology Impact factor: 2.512, year: 2014

  14. IL-9-Producing Mast Cell Precursors and Food Allergy

    Science.gov (United States)

    2016-10-01

    signaling enhances or attenuates allergic responses to food allergens. Methods: Mice of an IL-25 transgenic mouse line (iIL-25Tg mice), which...developing experimental food allergy, we generated IL-25 transgenic mouse lines (iIL-25Tg mice) that constitutively overexpress murine IL-25 driven by the...AD______________ AWARD NUMBER: W81XWH-15-1-0517 TITLE: IL-9-Producing Mast Cell Precursors and Food Allergy PRINCIPAL INVESTIGATOR: Dr. Yui

  15. Il processo Andreotti. Il confine labile fra la partecipazione e il concorso esterno nei reati associativi

    Directory of Open Access Journals (Sweden)

    Paolo Intoccia

    2017-11-01

    Full Text Available Prendendo in esame un procedimento penale d’eccezione nel presente elaborato ci si propone di condurre uno studio sul diritto penale ‘in azione’ allo scopo di verificare i meccanismi di applicazione dei reati di associazione per delinquere ‘semplice’ (a. 416 c.p. e di tipo mafioso (a. 416 bis c.p.. La seguente analisi ricostruisce, infatti, l’intensa trafila giudiziaria che ha visto protagonista Giulio Andreotti – dal 4 marzo 1993 chiamato a rispondere, prima a titolo di concorrente esterno e successivamente in qualità di partecipe, dei due reati associativi sopra richiamati a fronte di un apparato accusatorio qualitativamente complesso e temporalmente imponente. Sarà in tal modo possibile verificare quanto possa essere labile, specie ove si discuta della condotta di fiancheggiamento di un soggetto politico ad un sodalizio di tipo mafioso (qui Cosa Nostra, il confine tra la fenomenologia partecipativa (nel ruolo di intraneus all’associazione e quella concorsuale eventuale (nel ruolo di cd. concorrente esterno nei delitti associativi di cui agli artt. 416 e 416 bis c.p. Parole chiave: Andreotti, Cosa Nostra, zona grigia, reati associativi, mala informazione   By examining an exceptional criminal proceeding in this paper we propose to conduct a study on criminal law ‘in action’ in order to verify the mechanisms of application of two associative offenses (‘simple’ criminal conspiracy and mafia-type criminal conspiracy. As a matter of fact the analysis reconstructs the intense trial about Giulio Andreotti’s working with Cosa Nostra – Andreotti, starting from March 4 1993, is accused of being at first an external competitor and subsequently a participant of Cosa Nostra in connection with a qualitatively complex accusatory apparatus. As a result of this analysis we come to ascertain how fleeting the boundary between the role of partecipant and external competitor in a criminal conspiracy can be, especially in case of

  16. IL-6 and IL-8 level change in patients with PVR

    International Nuclear Information System (INIS)

    Han Li'na; Pan Xin; Zhang Xiaoguang

    2002-01-01

    Objective: To investigate the changes of interleutin-6 and interleutin-8 contents in vitreous body, sub-retinal fluid and serum of patients with proliferating vitro retinopathy. Methods: The levels of IL-6 and IL-8 in vitreous body, sub-retinal fluid and serum in thirty-four patients with PVR were measured with RIA. Another thirty patients with retina detachment were used as control group. Results: The level of IL-6 and IL-8 in vitreous body and sub-retinal fluid in the experiment group were significantly higher than those in control group, but the serum levels of IL-6 and IL-8 were about the same in both groups. Conclusion: The immunological system took part in the process of PVR mainly through local mechanism

  17. Espacio y territorio en perspectiva antropológica. El caso de los purhépechas de Nurío y Michoacán en México

    Directory of Open Access Journals (Sweden)

    Álvaro Bello

    2011-07-01

    Full Text Available En este artículo se analizan algunas perspectivas teóricas en torno a las categorías de territorio y espacio en contextos indígenas. Se trata de un análisis que intenta revisar las perspectivas tradicionales que vinculan territorio, práctica política y etnicidad en contextos indígenas. El problema es abordado en la perspectiva de la antropología política y la geografía del territorio, y toma como ejemplo el caso de los purhépechas de Michoacán en México. El desarrollo de este caso es relevante para la temática del territorio, pues Michoacán y lo purhépechas han sido un verdadero “laboratorio” de la antropología mexicana y norteamericana para aplicar conceptos y enfoques como “estudios de área”, “regiones de refugio” o “región indígena”. Por ello, es pertinente un análisis que permita revisar y cuestionar los supuestos que han estado a la base de dichas categorizaciones a partir de una perspectiva más centrada en los sujetos y sus formas de vivir y representar el espacio y el territorio.

  18. Cytokine vaccination: neutralising IL-1alpha autoantibodies induced by immunisation with homologous IL-1alpha

    DEFF Research Database (Denmark)

    Svenson, M; Hansen, M B; Thomsen, Allan Randrup

    2000-01-01

    High-affinity IgG autoantibodies (aAb) to IL-1alpha are among the most frequently found aAb to cytokines in humans. To establish an animal model with aAb to IL-1alpha, we immunised mice with recombinant murine IL-1alpha. Unprimed and Bacille Calmette-Guérin (BCG)-primed BALB/cA mice were vaccinat...

  19. Differential Regulation of IL-1β and IL-6 Release in Murine Macrophages.

    Science.gov (United States)

    Hirano, Seishiro; Zhou, Quan; Furuyama, Akiko; Kanno, Sanae

    2017-12-01

    Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1β release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome. However, the conversion of pro-IL-1β to its active form seems to depend on the macrophage cell types. In the present study, bone marrow-derived macrophages (BMM) and three murine macrophage cell lines, J774.1, J774A.1, and RAW264.7 were exposed to ATP or fibrous titanium dioxide (FTiO 2 ) in the presence or absence of lipopolysaccharide (LPS), and the concentrations of IL-1β and IL-6 in both cell lysates and in the culture media were measured by immunoblotting to differentiate active form of IL-1β from pro-IL-1β. IL-1β release was synergistically increased when the cells were exposed to both LPS and ATP or FTiO 2 , while IL-6 was readily released by LPS alone. IL-1β released into the culture medium was pro-IL-1β in J774.1 and RAW264.7, and most of the pro-IL-1β remained inside the cells. In contrast, the active form of IL-1β was released together with pro-IL-1β from J774A.1 and BMM after the co-stimulation. J774A.1 and BMM express apoptosis-associated speck-like protein contains a carboxyl-terminal CARD (ASC) while J774.1 and RAW264.7 do not or only faintly express ASC, and accordingly, caspase-1, which converts pro-IL-1β to its active form, is activated only in J774A.1 and BMM. Collectively, the canonical inflammasome pathway is not activated in J774.1 and RAW264.7, and the apparent synergistical increase of IL-1β in the culture medium mostly reflects the leakage of pro-IL-1β from these cells.

  20. Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells.

    Science.gov (United States)

    Gautier, Violette; Cayrol, Corinne; Farache, Dorian; Roga, Stéphane; Monsarrat, Bernard; Burlet-Schiltz, Odile; Gonzalez de Peredo, Anne; Girard, Jean-Philippe

    2016-10-03

    IL-33 is a nuclear cytokine from the IL-1 family that plays important roles in health and disease. Extracellular IL-33 activates a growing number of target cells, including group 2 innate lymphoid cells, mast cells and regulatory T cells, but it remains unclear whether intracellular nuclear IL-33 has additional functions in the nucleus. Here, we used a global proteomic approach based on high-resolution mass spectrometry to compare the extracellular and intracellular roles of IL-33 in primary human endothelial cells, a major source of IL-33 protein in human tissues. We found that exogenous extracellular IL-33 cytokine induced expression of a distinct set of proteins associated with inflammatory responses in endothelial cells. In contrast, knockdown of endogenous nuclear IL-33 expression using two independent RNA silencing strategies had no reproducible effect on the endothelial cell proteome. These results suggest that IL-33 acts as a cytokine but not as a nuclear factor regulating gene expression in endothelial cells.

  1. Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease

    Science.gov (United States)

    Kong, Su-Kang; Soo Kim, Byung; Gi Uhm, Tae; Soo Chang, Hun; Sook Park, Jong; Woo Park, Sung; Park, Choon-Sik; Chung, Il Yup

    2016-01-01

    Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the capacity of aspirin to induce interleukin-4 (IL-4) production in inflammatory cells relevant to AERD pathogenesis and examined the associated biochemical and molecular pathways. We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin. Aspirin induced IL-4 expression and activated the IL-4 promoter in a report assay. The capacity of aspirin to induce IL-4 expression correlated with its activity to activate mitogen-activated protein kinases, to form DNA–protein complexes on P elements in the IL-4 promoter and to synthesize nuclear factor of activated T cells, critical transcription factors for IL-4 transcription. Of clinical importance, aspirin upregulated IL-4 production twice as much in PBMCs from patients with AERD compared with PBMCs from patients with ATA. Our results suggest that IL-4 is an inflammatory component mediating intolerance reactions to aspirin, and thus is crucial for AERD pathogenesis. PMID:27534531

  2. Critical appraisal of four IL-6 immunoassays.

    Directory of Open Access Journals (Sweden)

    Dana K Thompson

    Full Text Available Interleukin-6 (IL-6 contributes to numerous inflammatory, metabolic, and physiologic pathways of disease. We evaluated four IL-6 immunoassays in order to identify a reliable assay for studies of metabolic and physical function. Serial plasma samples from intravenous glucose tolerance tests (IVGTTs, with expected rises in IL-6 concentrations, were used to test the face validity of the various assays.IVGTTs, administered to 14 subjects, were performed with a single infusion of glucose (0.3 g/kg body mass at time zero, a single infusion of insulin (0.025 U/kg body mass at 20 minutes, and frequent blood collection from time zero to 180 minutes for subsequent Il-6 measurement. The performance metrics of four IL-6 detection methods were compared: Meso Scale Discovery immunoassay (MSD, an Invitrogen Luminex bead-based multiplex panel (LX, an Invitrogen Ultrasensitive Luminex bead-based singleplex assay (ULX, and R&D High Sensitivity ELISA (R&D. IL-6 concentrations measured with MSD, R&D and ULX correlated with each other (Pearson Correlation Coefficients r = 0.47-0.94, p<0.0001 but only ULX correlated (r = 0.31, p = 0.0027 with Invitrogen Luminex. MSD, R&D, and ULX, but not LX, detected increases in IL-6 in response to glucose. All plasma samples were measurable by MSD, while 35%, 1%, and 4.3% of samples were out of range when measured by LX, ULX, and R&D, respectively. Based on representative data from the MSD assay, baseline plasma IL-6 (0.90 ± 0.48 pg/mL increased significantly as expected by 90 minutes (1.29 ± 0.59 pg/mL, p = 0.049, and continued rising through 3 hours (4.25 ± 3.67 pg/mL, p = 0.0048.This study established the face validity of IL-6 measurement by MSD, R&D, and ULX but not LX, and the superiority of MSD with respect to dynamic range. Plasma IL-6 concentrations increase in response to glucose and insulin, consistent with both an early glucose-dependent response (detectable at 1-2 hours and a late insulin-dependent response

  3. Territorio y desarrollo análisis de percepción en los municipios Rionegro y Sonsón - oriente antioqueño -

    OpenAIRE

    Pérez Zapata, Sara Edilia

    2010-01-01

    El texto es un ejercicio de interpretación de los procesos de desarrollo en los territorios de Sonsón y Rionegro, Oriente Antioqueño. Construido desde la percepción de los pobladores rurales, expresada en testimonios obtenidos de líderes comunitarios, a través de entrevistas semi-estructuradas, en las que se valoran las transformaciones ocurridas desde 1980 hasta 2008, en temas sociales, económicas y políticos. Se abordan los conflictos estructurales y coyunturales de la región como parte int...

  4. El proyecto arquitectónico como investigación. Una intervención en el territorio: El arroyo del Judío

    OpenAIRE

    Alarcón González, Luisa

    2015-01-01

    Esta tesis busca la confirmación de dos hipótesis: la primera es la consideración del proyecto arquitectónico como herramienta fundamental en la investigación de esta área de conocimiento, mientras que la segunda busca nuevas formas de ocupación del territorio por el hombre que se alejen de los modelos extensivos y depredadores que genera la ciudad actual. Estos son los puntos de partida desde los se ha trazado un camino que conduce de unas dudas iniciales a unos resultados finales como respu...

  5. Transformaciones del territorio Avá Guarani a partir de la construccion de la Usina Hidroelectrica Itaipu y por la actual expansion de la agricultura capitalista

    OpenAIRE

    Portillo Guillen, Rafael

    2015-01-01

    Trabajo de conclusión de curso presentado al Instituto Latinoamericano de Economía, Sociedad y Política de la Universidad Federal De la Integración Latinoamericana como requisito parcial para la obtención del título de Bacharel en Ciencia Política y Sociología. Orientadora: Profa. Dra. SenildeAlcantara Guanaes Las comunidades Avá Guaraní, situada en el departamento de Alto Paraná (Paraguay) y del Oeste de Paraná (Brasil) han pasado por un proceso de desplazamiento sobre su territorio...

  6. Valoraci??n del nivel de integraci??n agua-territorio en los instrumentos de planificaci??n de tres ??mbitos subregionales andaluces

    OpenAIRE

    Espa??a Villanueva, Mercedes Rosa

    2015-01-01

    La tesis persigue avanzar en la gesti??n integrada agua-territorio y para ello se propone intervenir en los instrumentos de planificaci??n territorial e hidrol??gica, describiendo un marco de referencia. Dicho marco est?? constituido por una serie de criterios de integraci??n que deber??n respetarse en los planes seg??n tres dimensiones: Informaci??n, Ejecuci??n y Coherencia. A partir de los criterios identificados y las dimensiones propuestas se presenta tambi??n una metodolog??a para valora...

  7. Distribución global y territorio. Modernización y concentración comercial en Argentina en los años noventa

    Directory of Open Access Journals (Sweden)

    Pablo Ciccolella

    2000-01-01

    vincular, por un lado, la evolución de su patrón de localización en función de las condiciones del mercado, el target y la evolución de la densidad comercial, es decir, considerando al territorio y a sus contenidos estratégicos y sociales como factor o insumo, y por otro lado, el estudio de las consecuencias socioterritoriales y urbanísticas y las formas territoriales que el despliegue de la actividad ha contribuido a generar, especialmente en los suburbios metropolitanos de Buenos Aires.

  8. CONSIDERANDOS PARA LAS SOLICITUDES DE TERRITORIOS LIBRES DE ORGANISMOS GENÉTICAMENTE ALTERADOS (TRANSGÉNICOS, CON ÉNFASIS EN COSTA RICA

    Directory of Open Access Journals (Sweden)

    Jaime E. García González

    2008-12-01

    Full Text Available Resumen Se exponen los considerandos de diverso tipo que justifican la declaratoria de territorios libres de organismos genéticamente alterados (transgénicos, haciendo un énfasis en la situación de Costa Rica. Los razonamientos descritos están ampliamente respaldados en los hechos concretos analizados en el contenido de las referencias bibliográficas del caso.   Abstract Diverse considerations are presented that justify the declaration of territories as transgenic-free zones, with emphasis on the situation in Costa Rica. The arguments described are supported by the concrete facts analyzed in the contents of the bibliographic references.

  9. Territorio, industria, trabajo : División territorial del trabajo y espacio producido en la industria de la ciudad de Tandil (Argentina)

    OpenAIRE

    Lan, Diana

    2011-01-01

    Las relaciones de las actividades industriales en el territorio se han modificado intensamente en el curso de las últimas décadas. Estos cambios explican inicialmente las mutaciones en las estrategias espaciales de los actores. Las últimas modificaciones han debido adaptarse a la rapidez de las transformaciones de la industria que se impusieron acompañando a las clases dominantes, de los contextos económicos y políticos de la actividad industrial. La industria está sometida a dos tendencias, ...

  10. La planificación hidrológica de cuenca como instrumento de ordenación ambiental sobre el territorio

    OpenAIRE

    Pallarès Serrano, Anna

    2005-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada La tesis doctoral que aquí se resume estudia la coordinación de los diferentes planes administrativos que tienen entre sus objetivos principales la protección directa del medio físico (planes de ordenación del territorio, de urbanismo, de los espacios naturales y la planificación hidrológica de cuenca), con el objetivo de demostrar que las deficiencias que presenta el sistema de coordinación entre los planes estudiados h...

  11. Campañas de resistencia y necesidad de formación para la gobernabilidad y el etnodesarrollo en territorios ancestrales de comunidades negras/afrocolombianas

    OpenAIRE

    Daniel Gárces Carabalí

    2011-01-01

    Desde un marco histórico, político, económico, cultural y ambiental del Territorio Región del Pacífico en Colombia, el artículo da cuenta de los problemas ecológicos y ambientales causados por la minería ilegal en el Pacífico Caucano, y describe de una de las campañas de resistencia de las organizaciones y comunidades negras/afrocolombianas por la defensa de su patrimonio territorial. En ese horizonte, se propone una apuesta formativa, de acompañamiento y de apoyo institucional y gubernamenta...

  12. Profile of IL-2, IL-4, IL-10, IFN- ? , TNF- ? and KC-like cytokines in pregnant bitches

    Directory of Open Access Journals (Sweden)

    M.A.R. Feliciano

    2014-08-01

    Full Text Available The aim of this study was to determine the profile of IL-2, IL-4, IL-10, IFN-γ, and TNF-α cytokines and KC-like cells (natural killer in pregnant bitches, unpublished values for the species. A total of 27 females of the Shi Tzu, Pug, English Bulldog and French breeds, weighing 4-20kg and aged 4-6 years were used. Blood samples were collected from bitches during the anestrous and on the 2nd, 5th, 6th, 7th and 8th week of pregnancy. Serum levels of cytokines were measured by panel MILLIPLEX MAP (CCYTO-90K, MILLIPORE, Billerica, Massachusetts, USA validated for dogs. Twenty four females showed physiological pregnancy and three bitches showed pathological pregnancy. There was no difference between cytokine values during anestrous and gestational weeks of bitches (P>0.05. However, it was possible to verify the physiological behavior of serum levels during modulation of immune response in the gestational process of animals. In animals with gestational disorders, abnormal values for IL-2, IL-4 and INF-y were noted. It was concluded that serum levels of cytokines evaluated in pregnant bitches can help the better understanding of physiological and pathological gestational processes and correlated immunology in this species.

  13. Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP

    Directory of Open Access Journals (Sweden)

    A Seda Yılmaz-Eliş

    2013-01-01

    Full Text Available The cytokine interleukin 1(IL-1 initiates a wide range of proinflammatory cascades and its inhibition has been shown to decrease inflammation in a variety of diseases. IL-1 receptor accessory protein (IL-1RAcP is an indispensible part of the IL-1R complex that stabilizes IL-1/IL-1R interaction and plays an important role in the signal transduction of the receptor complex. The soluble form of IL-1RAcP (sIL-1RAcP contains only the extracellular domain and serves as a natural inhibitor of IL-1 signaling. Therefore, increasing sIL-1RAcP levels might be an attractive therapeutic strategy to inhibit IL-1–driven inflammation. To achieve this we designed specific antisense oligonucleotides (AON, to redirect pre-mRNA IL-1RAcP splicing by skipping of the transmembrane domain encoding exon 9. This would give rise to a novel Δ9IL-1RAcP mRNA encoding a soluble, secreted form of IL-1RAcP, which might have similar activity as natural sIL-1RAcP. AON treatment resulted in exon 9 skipping both in vitro and in vivo. A single dose injection of 10 mg AON/kg body weight induced 90% skipping in mouse liver during at least 5 days. The truncated mRNA encoded for a secreted, soluble Δ9IL-1RAcP protein. IL-1RAcP skipping resulted in a substantial inhibition of IL-1 signaling in vitro. These results indicate that skipping of the transmembrane encoding exon 9 of IL-1RAcP using specific AONs might be a promising therapeutic strategy in a variety of chronic inflammatory diseases.

  14. Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP)

    Science.gov (United States)

    Yılmaz-Eliş, A Seda; Aartsma-Rus, Annemieke; ‘t Hoen, Peter AC; Safdar, Huma; Breukel, Cor; van Vlijmen, Bart JM; van Deutekom, Judith; de Kimpe, Sjef; van Ommen, Gert-Jan; Verbeek, J Sjef

    2013-01-01

    The cytokine interleukin 1(IL-1) initiates a wide range of proinflammatory cascades and its inhibition has been shown to decrease inflammation in a variety of diseases. IL-1 receptor accessory protein (IL-1RAcP) is an indispensible part of the IL-1R complex that stabilizes IL-1/IL-1R interaction and plays an important role in the signal transduction of the receptor complex. The soluble form of IL-1RAcP (sIL-1RAcP) contains only the extracellular domain and serves as a natural inhibitor of IL-1 signaling. Therefore, increasing sIL-1RAcP levels might be an attractive therapeutic strategy to inhibit IL-1–driven inflammation. To achieve this we designed specific antisense oligonucleotides (AON), to redirect pre-mRNA IL-1RAcP splicing by skipping of the transmembrane domain encoding exon 9. This would give rise to a novel Δ9IL-1RAcP mRNA encoding a soluble, secreted form of IL-1RAcP, which might have similar activity as natural sIL-1RAcP. AON treatment resulted in exon 9 skipping both in vitro and in vivo. A single dose injection of 10 mg AON/kg body weight induced 90% skipping in mouse liver during at least 5 days. The truncated mRNA encoded for a secreted, soluble Δ9IL-1RAcP protein. IL-1RAcP skipping resulted in a substantial inhibition of IL-1 signaling in vitro. These results indicate that skipping of the transmembrane encoding exon 9 of IL-1RAcP using specific AONs might be a promising therapeutic strategy in a variety of chronic inflammatory diseases. PMID:23340324

  15. Modulation of pulmonary fibrosis by IL-13Rα2.

    Science.gov (United States)

    Lumsden, Robert V; Worrell, Julie C; Boylan, Denise; Walsh, Sinead M; Cramton, Jennifer; Counihan, Ian; O'Beirne, Sarah; Medina, Maria Fe; Gauldie, Jack; Fabre, Aurelie; Donnelly, Seamas C; Kane, Rosemary; Keane, Michael P

    2015-04-01

    Pulmonary fibrosis is a progressive and fatal disease that involves the remodeling of the distal airspace and the lung parenchyma, which results in compromised gas exchange. The median survival time once diagnosed is less than three years. Interleukin (IL)-13 has been shown to play a role in a number of inflammatory and fibrotic diseases. IL-13 modulates its effector functions via a complex receptor system that includes the IL-4 receptor (R) α, IL-13Rα1, and the IL-13Rα2. IL-13Rα1 binds IL-13 with low affinity, yet, when it forms a complex with IL-4α, it binds with much higher affinity, inducing the effector functions of IL-13. IL-13Rα2 binds IL-13 with high affinity but has a short cytoplasmic tail and has been shown to act as a nonsignaling decoy receptor. Transfection of fibroblasts and epithelial cells with IL-13Rα2 inhibited the IL-13 induction of soluble collagen, TGF-β, and CCL17. Adenoviral overexpression of IL-13Rα2 in the lung reduced bleomycin-induced fibrosis. Our work shows that overexpression of IL-13Rα2 inhibits the IL-13 induction of fibrotic markers in vitro and inhibits bleomycin-induced pulmonary fibrosis. In summary our study highlights the antifibrotic nature of IL-13Ra2. Copyright © 2015 the American Physiological Society.

  16. Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice.

    Directory of Open Access Journals (Sweden)

    Carol L Murray

    Full Text Available Interleukin-1 (IL-1 is a key pro-inflammatory cytokine, produced predominantly by peripheral immune cells but also by glia and some neuronal populations within the brain. Its signalling is mediated via the binding of IL-1α or IL-1β to the interleukin-1 type one receptor (IL-1RI. IL-1 plays a key role in inflammation-induced sickness behaviour, resulting in depressed locomotor activity, decreased exploration, reduced food and water intake and acute cognitive deficits. Conversely, IL-1 has also been suggested to facilitate hippocampal-dependent learning and memory: IL-1RI(-/- mice have been reported to show deficits on tasks of visuospatial learning and memory. We sought to investigate whether there is a generalised hippocampal deficit in IL-1RI(-/- animals. Therefore, in the current study we compared wildtype (WT mice to IL-1RI(-/- mice using a variety of hippocampal-dependent learning and memory tasks, as well as tests of anxiety and locomotor activity. We found no difference in performance of the IL-1RI(-/- mice compared to WT mice in a T-maze working memory task. In addition, the IL-1RI(-/- mice showed normal learning in various spatial reference memory tasks including the Y-maze and Morris mater maze, although there was a subtle deficit in choice behaviour in a spatial discrimination, beacon watermaze task. IL-1RI(-/- mice also showed normal memory for visuospatial context in the contextual fear conditioning paradigm. In the open field, IL-1RI(-/- mice showed a significant increase in distance travelled and rearing behaviour compared to the WT mice and in the elevated plus-maze spent more time in the open arms than did the WT animals. The data suggest that, contrary to prior studies, IL-1RI(-/- mice are not robustly impaired on hippocampal-dependent memory and learning but do display open field hyperactivity and decreased anxiety compared to WT mice. The results argue for a careful evaluation of the roles of endogenous IL-1 in hippocampal

  17. IL-18 paradox in pancreatic carcinoma: elevated serum levels of free IL-18 are correlated with poor survival.

    Science.gov (United States)

    Carbone, Anna; Vizio, Barbara; Novarino, Anna; Mauri, Francesco Angelo; Geuna, Massimo; Robino, Carlo; Brondino, Gabriele; Prati, Adriana; Giacobino, Alice; Campra, Donata; Chiarle, Roberto; Fronda, Gian Ruggero; Ciuffreda, Libero; Bellone, Graziella

    2009-01-01

    The role of the proinflammatory interleukin (IL)-18 in cancer progression remains controversial; we thus examined the hypothesis that impaired antitumor immune response in pancreatic carcinoma patients is related to elevated levels of its natural inhibitor IL-18 binding protein (BP) and/or to alteration in the IL-18 receptor complex expression and function. IL-18 and IL-18 binding protein isoform a (BPa) was assessed in pancreatic carcinoma patients at various disease stages, and after surgery/chemotherapy; free bioactive IL-18 concentrations were calculated. IL-18 receptor complex expression in lymphocyte subsets was analyzed and signaling function was assessed versus healthy donors. Carcinoma cells exhibited below normal IL-18BPa expression and above normal IL-18 expression. Circulating IL-18BPa and IL-18 were above controls. Unexpectedly, free unbound IL-18 serum levels were correlated with disease severity and poor survival. IL-18BPa levels were unchanged by surgery but free IL-18 levels were elevated. Gemcitabine with 5-fluorouracil or oxaliplatin, but not alone, increased IL-18 and free IL-18 levels statistically significantly, without affecting IL-18BPa. Spontaneous/induced IL-18 receptor alpha and receptor beta expression in peripheral blood lymphocyte subsets from patients with advanced disease were near-normal, although CD4+ and CD8+ cells were fewer in percentage, and fully functional in inducing interferon-gamma. IL-18 is proposed as novel adjuvant cancer therapy, but free IL-18 levels are increased in the blood of pancreatic carcinoma patients, despite elevated IL-18BP levels, and are associated with poor survival; this highlights recent experimental insights into the prometastatic and proangiogenic effects of IL-18, and suggests that careful preclinical studies are needed to determine the proper application of IL-18 in cancer therapy.

  18. Three-Dimensional Conformal Radiotherapy in Prostate Cancer Patients: Rise in Interleukin 6 (IL-6) but not IL-2, IL-4, IL-5, Tumor Necrosis Factor-{alpha}, MIP-1-{alpha}, and LIF Levels

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira Lopes, Carlos [Universidade do Vale do Paraiba, Centro de Oncologia Radioterapica do Vale do Paraiba, Universidade do Vale do Paraiba Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraiba, Sao Jose dos Campos, Sao Paulo (Brazil); Callera, Fernando, E-mail: fcallera@gmail.com [Centro de Hematologia Onco-hematologia e Transplantes de Medula Ossea do Vale do Paraiba, Sao Paulo (Brazil)

    2012-03-15

    Purpose: To investigate the effect of radiotherapy (RT) on serum levels of interleukin-2 (IL-2), IL-4, IL-5, IL-6, tumor necrosis factor alpha (TNF-{alpha}), macrophage inflammatory protein-1-alpha (MIP-1-{alpha}) and leukemia inhibitory factor (LIF) in patients with prostate cancer. Methods and Materials: Forty eight patients with prostate cancer received three-dimensional conformal blocking radiation therapy with a linear accelerator. IL-2, IL-4, IL-5, IL-6, TNF-{alpha}, MIP-1-{alpha}, and LIF levels were measured by the related immunoassay kit 1 day before the beginning of RT and during RT at days 15 and 30. Results: The mean IL-2 values were elevated before and during the RT in contrast with those of IL-4, IL-5, IL-6, TNF-{alpha}, MIP-1-{alpha}, and LIF, which were within the normal range under the same conditions. Regarding markers IL-2, IL-4, IL-5, TNF-{alpha}, MIP-1-{alpha}, and LIF, comparisons among the three groups (before treatment and 15 and 30 days during RT) did not show significant differences. Although values were within the normal range, there was a significant rise in IL-6 levels at day 15 of RT (p = 0.0049) and a decline at day 30 to levels that were similar to those observed before RT. Conclusions: IL-6 appeared to peak after 15 days of RT before returning to pre-RT levels. In contrast, IL-2, IL-4, IL-5, TNF-{alpha}, MIP-1-{alpha}, and LIF levels were not sensitive to irradiation. The increased levels of IL-6 following RT without the concurrent elevation of other cytokines involved in the acute phase reaction did not suggest a classical inflammatory response to radiation exposure. Further studies should be designed to elucidate the role of IL-6 levels in patients with prostate cancer treated with RT.

  19. Andrographolide presents therapeutic effect on ulcerative colitis through the inhibition of IL-23/IL-17 axis.

    Science.gov (United States)

    Zhu, Qin; Zheng, Peifen; Chen, Xinyu; Zhou, Feng; He, Qiaona; Yang, Yuefeng

    2018-01-01

    Ulcerative colitis (UC) is a chronic and nonspecific intestinal inflammatory disease, which may increase the risk of colon cancer. Andrographolide is a main active component of Andrographis paniculata . The anti-inflammatory ability of andrographolide suggested its potential therapeutic effect against UC. In the present study, elevated serum concentrations of proinflammatory factors, including (TNF)-α, interleukin (IL)-1β, IL-6 and IL-23, as well as increased percentages of Th17 cells (IL-17+CD4+ cells) in CD4+ cells were detected in UC patients compared to that in healthy donors. These data suggested that Th17 immune responses may involve in the pathogenesis of UC. Experimental colitis mouse model was then established. The results of hematoxylin and eosin staining demonstrated the therapeutic effect of andrographolide on colitis. Enzyme-linked immunosorbent assay (ELISA), flow cytometry and western blotting analyses showed that andrographolide could decreased the levels of proinflammatory factors TNF-α, IL-1β, IL-6 and IL-17A in the serum and in the colon tissues, reduced the percentages of Th17 cells in CD4+ cells, and suppressed the levels of IL-23, IL-17A, ROR-γt (key transcription factor of Th17 cells) and p-STAT3 in the colon tissues. Further, peripheral blood mononuclear cells (PBMCs) were isolated from UC patients and treated with various concentrations of andrographolide (0, 10, 20 and 30 μg/ml). Andrographolide also showed inhibitory effects on the levels of proinflammatory factors, the percentages of Th17 cells and the expression of relative proteins. Similar results were obtained in lipopolysaccharide-treated normal PBMCs. These data suggested that andrographolide may inhibit Th17 immune response via STAT3 signaling. In conclusion, we demonstrated that andrographolide inhibited the activity of IL-23/IL-17 axis and down-stream pro-inflammatory factors so as to suppress inflammation response, resulting in the relieving of UC.

  20. A Brief History of IL-1 and IL-1 Ra in Rheumatology

    Directory of Open Access Journals (Sweden)

    Jean-Michel Dayer

    2017-05-01

    Full Text Available The history of what, in 1979, was called interleukin-1 (IL-1, orchestrator of leukocyte inter-communication, began many years before then, initially by the observation of fever induction via the endogenous pyrogen (EP (1974 and then in rheumatology on the role in tissue destruction in rheumatoid diseases via the induction of collagenase and PGE2 in human synovial cells by a mononuclear cell factor (MCF (1977. Since then, the family has exploded to presently 11 members as well as many membrane-bound and soluble receptor forms. The discovery of a natural Interleukin-1 receptor antagonist (IL-1Ra in human biological fluids has highlighted the importance of IL-1 and IL-1Ra in human diseases. Evidence delineating its role in autoinflammatory syndromes and the elucidation of the macromolecular complex referred to as “inflammasome” have been instrumental to our understanding of the link with IL-1. At present, the IL-1blockade as therapeutic approach is crucial for many hereditary autoinflammatory diseases, as well as for adult-onset Still’s disease, crystal-induced arthropathies, certain skin diseases including neutrophil-triggered skin diseases, Behçet’s disease and deficiency of IL-1Ra and other rare fever syndromes. Its role is only marginally important in rheumatoid arthritis and is still under debate with regard to osteoarthritis, type 2 diabetes mellitus, cardiovascular diseases and cancer. This brief historical review focuses on some aspects of IL-1, mainly IL-1β and IL-Ra, in rheumatology. There are many excellent reviews focusing on the IL-1 family in general or with regard to specific diseases or biological discoveries.

  1. Territorio, moral y nación en los pupitres de la escuela. Olavo Bilac y Manoel Bomfim

    Directory of Open Access Journals (Sweden)

    Rodrigues-Moura, Enrique

    2007-04-01

    Full Text Available The aim of the nationalisms of the nineteenth century to form a homogeneous people, made up of citizens, became a goal of the so-called Brazilian Generation of 1870, which fought hard to adapt the European civilization to the Brazilian reality. Olavo Bilac and Manoel Bomfim, inheritors of those worries but active in public life only after the Primeira República (1889-1930, considered public education the ideal means (1 to achieve an image of a unified Brazilian people, with the given varieties, (2 to present a big national territory, (3 to establish certain basic moral concepts and (4 to further patriotism. This article is about the book, written by the two authors mentioned above, Atravez do Brasil. Livro de leitura para o curso medio das Escolas Primarias (1910, a story which condenses a nationalist effort still based on European models, but already adapted to the young República do Brasil.El objetivo de los nacionalismos decimonónicos de formar un pueblo homogéneo, constituido por ciudadanos, pasó a ser una preocupación de la denominada generación brasileña de 1870, que tanto luchó por adaptar la civilización europea a la realidad brasileña. Olavo Bilac y Manoel Bomfim, herederos de estas preocupaciones, pero activos en la vida pública sólo a partir de la Primeira República (1889-1930, apostaron por la instrucción pública como medio ideal para (1 ofrecer una representación unificada, dentro de su variedad, del pueblo brasileño, (2 presentar su amplio territorio nacional, (3 aportar unos conceptos morales básicos y (4 fomentar el patriotismo. Este artículo estudia el libro que escribieron a cuatro manos, Atravez do Brasil. Livro de leitura para o curso medio das Escolas Primarias (1910, narración que condensa un esfuerzo nacionalista basado todavía en modelos europeos, pero ya adaptados a la joven República do Brasil.

  2. UNIFORMIDAD FISCAL VERSUS TERRITORIOS PRIVILEGIADOS EN LA ESPAÑA DEL SIGLO XVIII: LOS CASOS DE NAVARRA Y CANARIAS

    Directory of Open Access Journals (Sweden)

    Sergio Solbes Ferri

    2014-12-01

    Full Text Available El trabajo se organiza desde una doble reflexión. Por un lado, el éxito o el fracaso en la aplicación de los proyectos de reforma fiscal diseñados para su imposición en el conjunto de la Monarquía española en la primera mitad del siglo XVIII. Por otro lado, el éxito o el fracaso en la defensa de los privilegios fiscales de Navarra y de Canarias, territorios en los que Felipe V no pudo, ni quiso, imponer el derecho de conquista tras la guerra de Sucesión. Analizamos estas especificidades con la intención de conocer aquellos aspectos que perduran en el tiempo y aquellos que desaparecen. Finalmente, tratamos de reflexionar sobre si el resultado final es la consecuencia necesaria de un proyecto de reforma preconcebido o de una simple adaptación a las circunstancias propias del devenir histórico. Apostamos por la primera solución, así que tratamos en integrar los cambios implementados con el pensamiento y los programas de reforma diseñados por Alberoni y Patiño.AbstractThis study is organized from a double perspective. Firstly, the success or failure in the implementation of projects designed to reform taxation in the whole Spanish monarchy during the first half of the eighteenth century. On the other hand, the success or failure in defending the fiscal privileges of Navarra and Canarias, territories in which Philip V could not impose the right of conquest after the War of Succession. We analyse these specificities with the intention of meeting those aspects that remain and those that disappear. Lastly, we try to reflect if the final status is the result of a preconceived reform project or a simple adaptation to the circumstances of the historical development. We focus on the first solution, so we try to relate the implemented changes with the Alberoni and Patiño reform programs.

  3. Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex

    Energy Technology Data Exchange (ETDEWEB)

    Logsdon, Naomi J.; Allen, Christopher E.; Rajashankar, Kanagalaghatta R.; Walter, Mark R. (Cornell); (UAB)

    2012-02-08

    Interleukin-20 (IL-20) is an IL-10-family cytokine that regulates innate and adaptive immunity in skin and other tissues. In addition to protecting the host from various external pathogens, dysregulated IL-20 signaling has been shown to contribute to the pathogenesis of human psoriasis. IL-20 signals through two cell-surface receptor heterodimers, IL-20R1-IL-20R2 and IL-22R1-IL-20R2. In this report, crystals of the IL-20-IL-20R1-IL-20R2 ternary complex have been grown from polyethylene glycol solutions. The crystals belonged to space group P4{sub 1}2{sub 1}2 or P4{sub 3}2{sub 1}2, with unit-cell parameters a = 111, c = 135 {angstrom}, and diffracted X-rays to 3 {angstrom} resolution. The crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%.

  4. BALANCE DE LOS QUINCE AÑOS DEL PLAN COLOMBIA (2001-2016 Recuperación de la Institucionalidad Colombiana y Consolidación de la Presencia del Estado en el Territorio Nacional

    Directory of Open Access Journals (Sweden)

    Julio Cesar Ramírez Montañez

    2017-04-01

    Full Text Available En el transcurso de los últimos 15 años, los gobiernos de los Estados Unidos y Colombia han trabajado conjuntamente para luchar contra el problema de seguridad más importante que ha enfrentado el continente americano en las postrimerías del siglo XXI. Los grupos Narco terroristas colombianos se convirtieron en la principal amenaza para la seguridad nacional de los Estados Unidos en el hemisferio occidental; no sólo a causa de la producción de drogas y el tráfico de drogas, sino también de las actividades terroristas en contra de los intereses de los Estados Unidos en la región. El Plan Colombia fue una estrategia que tuvo como propósito principal establecer y garantizar un Estado que pudiera ejercer su verdadera autoridad y cumplir con sus obligaciones esenciales. De igual forma, este plan tuvo un componente militar con el fin de poner fin al comercio de drogas mediante la erradicación de cultivos ilícitos. Algunos objetivos del Plan Colombia como reducir el cultivo, procesamiento y distribución de narcóticos ilegales atacando el cultivo de coca no se cumplieron, además, durante estos años el fenómeno de la minería ilegal comenzó a prosperar y se convirtió en una importante fuente de ingresos para los grupos narcoterroristas colombianos. Dentro de los Principales logros se puede establecer que con esta estrategia el Estado Colombiano ha logrado la recuperación de su institucionalidad y la consolidación de la presencia del gobierno en todas las áreas del territorio nacional, así como la reestructuración del sistemas políticos y jurídicos, el fortalecimiento de su economía, la profesionalización de las Fuerzas Armadas y la posibilidad de iniciar un proceso de negociación con las Fuerzas Armadas Revolucionarias de Colombia (FARC y el Ejército de Liberación Nacional (ELN.

  5. Espacios y territorio en la propaganda y en los discursos durante los conflictos bélicos: la Guerra de Sucesión en España y América

    Directory of Open Access Journals (Sweden)

    David González Cruz

    2012-01-01

    Full Text Available Cette recherche aborde l’utilisation du concept de territoire et la symbologie des espaces géographiques comme éléments de la stratégie définie pour obtenir l’adhésion de l’opinion publique en faveur des intérêts des puissances et des dynasties belligérantes lors de la Guerre de Succession d’Espagne. Il s’agit d’approfondir les mécanismes et les discours employés pour générer adhésion ou rejet envers les adversaires dans les domaines de la Monarchie, en Espagne et en Amérique : messages diffusant des stéréotypes humains liés à des royaumes ou à des régions, discours à contenu religieux visant à diaboliser les ennemis, campagnes fustigeant les étrangers en fonction de leur nationalité, références à l’histoire pour appuyer des comportements présents, ou allusions récurrentes aux pertes territoriales ou à la possible désintégration de la Monarchie comme conséquences de la guerre ou des négociations de paix.Esta investigación aborda la utilización del concepto de territorio y la simbología de los espacios geográficos como elementos de la estrategia diseñada para atraer a la opinión pública hacia los intereses de las potencias y dinastías beligerantes en la Guerra de Sucesión española. Se trata de profundizar en los mecanismos y discursos empleados para generar adhesiones o rechazo a los adversarios en los dominios de la Monarquía en España y América; entre ellos los mensajes que difundían estereotipos humanos vinculados a reinos o regiones, los discursos de contenido religioso con el fin de demonizar a los enemigos, las campañas estigmatizadoras de los extranjeros en función de su nacionalidad, las referencias a la historia como sostén de comportamientos presentes, o las recurrentes alusiones a las pérdidas territoriales o posible desintegración de la Monarquía como consecuencia de la guerra o de las negociaciones de paz.

  6. IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex

    Directory of Open Access Journals (Sweden)

    Tae Sik Goh

    2017-01-01

    Full Text Available IL-7 signaling via IL-7Rα and common γ-chain (γc is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-7Rα and γc in the absence or presence of IL-7 remains unclear. Additionally, we are still uncertain as to how only IL-7Rα is separately downregulated by the binding of IL-7 from the IL-7Rα/γc complex. We demonstrate here that 4G3, TUGm2, and 3E12 epitope masking of γc protein are induced in the presence of IL-7, indicating that the epitope alteration is induced by IL-7 binding to the preassembled receptor core. Moreover, the epitope masking of γc protein is inversely correlated with the expression of IL-7Rα upon IL-7 binding, implying that the structural alteration of γc might be involved in the regulation of IL-7Rα expression. The conformational change in γc upon IL-7 binding may contribute not only to forming the functional IL-7 signaling complex but also to optimally regulating the expression of IL-7Rα.

  7. IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex

    Science.gov (United States)

    Goh, Tae Sik; Jo, Yuna; Lee, Byunghyuk; Kim, Geona; Hwang, Hyunju; Ko, Eunhee; Kang, Seung Wan; Oh, Sae-Ock; Baek, Sun-Yong; Yoon, Sik; Lee, Jung Sub

    2017-01-01

    IL-7 signaling via IL-7Rα and common γ-chain (γc) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-7Rα and γc in the absence or presence of IL-7 remains unclear. Additionally, we are still uncertain as to how only IL-7Rα is separately downregulated by the binding of IL-7 from the IL-7Rα/γc complex. We demonstrate here that 4G3, TUGm2, and 3E12 epitope masking of γc protein are induced in the presence of IL-7, indicating that the epitope alteration is induced by IL-7 binding to the preassembled receptor core. Moreover, the epitope masking of γc protein is inversely correlated with the expression of IL-7Rα upon IL-7 binding, implying that the structural alteration of γc might be involved in the regulation of IL-7Rα expression. The conformational change in γc upon IL-7 binding may contribute not only to forming the functional IL-7 signaling complex but also to optimally regulating the expression of IL-7Rα. PMID:28127156

  8. High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.

    Science.gov (United States)

    Binger, Katrina J; Gebhardt, Matthias; Heinig, Matthias; Rintisch, Carola; Schroeder, Agnes; Neuhofer, Wolfgang; Hilgers, Karl; Manzel, Arndt; Schwartz, Christian; Kleinewietfeld, Markus; Voelkl, Jakob; Schatz, Valentin; Linker, Ralf A; Lang, Florian; Voehringer, David; Wright, Mark D; Hubner, Norbert; Dechend, Ralf; Jantsch, Jonathan; Titze, Jens; Müller, Dominik N

    2015-11-02

    A high intake of dietary salt (NaCl) has been implicated in the development of hypertension, chronic inflammation, and autoimmune diseases. We have recently shown that salt has a proinflammatory effect and boosts the activation of Th17 cells and the activation of classical, LPS-induced macrophages (M1). Here, we examined how the activation of alternative (M2) macrophages is affected by salt. In stark contrast to Th17 cells and M1 macrophages, high salt blunted the alternative activation of BM-derived mouse macrophages stimulated with IL-4 and IL-13, M(IL-4+IL-13) macrophages. Salt-induced reduction of M(IL-4+IL-13) activation was not associated with increased polarization toward a proinflammatory M1 phenotype. In vitro, high salt decreased the ability of M(IL-4+IL-13) macrophages to suppress effector T cell proliferation. Moreover, mice fed a high salt diet exhibited reduced M2 activation following chitin injection and delayed wound healing compared with control animals. We further identified a high salt-induced reduction in glycolysis and mitochondrial metabolic output, coupled with blunted AKT and mTOR signaling, which indicates a mechanism by which NaCl inhibits full M2 macrophage activation. Collectively, this study provides evidence that high salt reduces noninflammatory innate immune cell activation and may thus lead to an overall imbalance in immune homeostasis.

  9. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.

    Science.gov (United States)

    Vom Berg, Johannes; Prokop, Stefan; Miller, Kelly R; Obst, Juliane; Kälin, Roland E; Lopategui-Cabezas, Ileana; Wegner, Anja; Mair, Florian; Schipke, Carola G; Peters, Oliver; Winter, York; Becher, Burkhard; Heppner, Frank L

    2012-12-01

    The pathology of Alzheimer's disease has an inflammatory component that is characterized by upregulation of proinflammatory cytokines, particularly in response to amyloid-β (Aβ). Using the APPPS1 Alzheimer's disease mouse model, we found increased production of the common interleukin-12 (IL-12) and IL-23 subunit p40 by microglia. Genetic ablation of the IL-12/IL-23 signaling molecules p40, p35 or p19, in which deficiency of p40 or its receptor complex had the strongest effect, resulted in decreased cerebral amyloid load. Although deletion of IL-12/IL-23 signaling from the radiation-resistant glial compartment of the brain was most efficient in mitigating cerebral amyloidosis, peripheral administration of a neutralizing p40-specific antibody likewise resulted in a reduction of cerebral amyloid load in APPPS1 mice. Furthermore, intracerebroventricular delivery of antibodies to p40 significantly reduced the concentration of soluble Aβ species and reversed cognitive deficits in aged APPPS1 mice. The concentration of p40 was also increased in the cerebrospinal fluid of subjects with Alzheimer's disease, which suggests that inhibition of the IL-12/IL-23 pathway may attenuate Alzheimer's disease pathology and cognitive deficits.

  10. Interleukin (IL)-17A and IL-17F and asthma in Saudi Arabia: mRNA ...

    African Journals Online (AJOL)

    Interleukin (IL)-17A and IL-17F and asthma in Saudi Arabia: mRNA transcript levels and gene polymorphisms. MD Bazzi, MA Sultan, N Al Tassan, M Alanazi, A Al-Amri, MS Al-Hajjaj, S Al-muhsen, K Alba-Concepcion, A Warsy ...

  11. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

    NARCIS (Netherlands)

    Festen, E. A. M.; Goyette, P.; Scott, R.; Annese, V.; Zhernakova, A.; Lian, J.; Lefebvre, C.; Brant, S. R.; Cho, J. H.; Silverberg, M. S.; Taylor, K. D.; de Jong, D. J.; Stokkers, P. C.; Mcgovern, D.; Palmieri, O.; Achkar, J-P; Xavier, R. J.; Daly, M. J.; Duerr, R. H.; Wijmenga, C.; Weersma, R. K.; Rioux, J. D.

    Objectives: Genetic susceptibility is known to play a large part in the predisposition to the inflammatory bowel diseases (IBDs) known as Crohn's disease (CD) and ulcerative colitis (UC). The IL2/IL21 locus on 4q27 is known to be a common risk locus for inflammatory disease (shown in coeliac

  12. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

    NARCIS (Netherlands)

    Festen, E.A.M.; Goyette, P.; Scott, R.; Annese, V.; Zhernakova, A.; Lian, J.; Lefèbvre, C.; Brant, S.R.; Cho, J.H.; Silverberg, M.S.; Taylor, K.D.; de Jong, D.J.; Stokkers, P.C.; Mcgovern, D.; Palmieri, O.; Achkar, J.P.; Xavier, R.J.; Daly, M.J.; Duerr, R.H.; Wijmenga, C.; Weersma, R.K.; Rioux, J.D.

    2009-01-01

    Objectives: Genetic susceptibility is known to play a large part in the predisposition to the inflammatory bowel diseases (IBDs) known as Crohn's disease (CD) and ulcerative colitis (UC). The IL2/IL21 locus on 4q27 is known to be a common risk locus for inflammatory disease (shown in coeliac

  13. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

    NARCIS (Netherlands)

    Festen, E. A. M.; Goyette, P.; Scott, R.; Annese, V.; Zhernakova, A.; Lian, J.; Lefèbvre, C.; Brant, S. R.; Cho, J. H.; Silverberg, M. S.; Taylor, K. D.; de Jong, D. J.; Stokkers, P. C.; Mcgovern, D.; Palmieri, O.; Achkar, J.-P.; Xavier, R. J.; Daly, M. J.; Duerr, R. H.; Wijmenga, C.; Weersma, R. K.; Rioux, J. D.

    2009-01-01

    Genetic susceptibility is known to play a large part in the predisposition to the inflammatory bowel diseases (IBDs) known as Crohn's disease (CD) and ulcerative colitis (UC). The IL2/IL21 locus on 4q27 is known to be a common risk locus for inflammatory disease (shown in coeliac disease, type 1

  14. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.

    NARCIS (Netherlands)

    Festen, E.A.; Goyette, P.; Scott, R.; Annese, V.; Zhernakova, A.; Lian, J.; Lefebvre, C.; Brant, S.R.; Cho, J.H.; Silverberg, M.S.; Taylor, K.D.; Jong, D.J. de; Stokkers, P.C.; Mcgovern, D.; Palmieri, O.; Achkar, J.P.; Xavier, R.J.; Daly, M.J.; Duerr, R.H.; Wijmenga, C.; Weersma, R.K.; Rioux, J.D.

    2009-01-01

    OBJECTIVES: Genetic susceptibility is known to play a large part in the predisposition to the inflammatory bowel diseases (IBDs) known as Crohn's disease (CD) and ulcerative colitis (UC). The IL2/IL21 locus on 4q27 is known to be a common risk locus for inflammatory disease (shown in coeliac

  15. Diagnostic significance of IL-6 and IL-8 in tubal ectopic pregnancy.

    Science.gov (United States)

    Rajendiran, Soundravally; Senthil Kumar, G P; Nimesh, Archana; Dhiman, Pooja; Shivaraman, K; Soundararaghavan, S

    2016-10-01

    As there are no specific non-invasive markers for the diagnosis of tubal ectopic pregnancy, our objective in the present study was to explore the role of inflammatory cytokines IL-6 and IL-8 in the diagnosis of ruptured tubal ectopic pregnancy. Twenty-eight women with tubal ectopic pregnancy, 31 patients with intrauterine abortion and 29 gestational age matched women having normal intrauterine pregnancy were included in the study. Five millilitre of blood was collected at the time of admission, serum was separated and stored at -70 °C for subsequent analysis of β hCG, IL-6 and IL-8 levels. The level of IL-6 was a significant increase in the women with tubal ectopic pregnancy compared to intrauterine abortion and normal pregnancy. IL-8 levels decrease significantly in the tubal ectopic pregnancy and in intrauterine abortion patients when compared with the normal pregnancy group. At the cutoff of 26.48 pg/ml IL-6 level predicted the tubal ectopic pregnancy with moderate accuracy. Therefore, it can be concluded that measurement of IL-6 may have relevance in the diagnosis of ectopic pregnancy as a novel inflammatory serum biomarkers.

  16. Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10.

    Science.gov (United States)

    Moreira, Fernanda Pedrotti; Medeiros, João Ricardo Carvalho; Lhullier, Alfredo Cardoso; Souza, Luciano Dias de Mattos; Jansen, Karen; Portela, Luis Valmor; Lara, Diogo R; da Silva, Ricardo Azevedo; Wiener, Carolina David; Oses, Jean Pierre

    2016-01-01

    Cocaine abuse is capable of activating the innate immune system in the CNS resulting in deregulation of homeostasis between pro and antiinflammatory cytokines. The aim of this study was to investigate serum levels of pro and antiinflammatory cytokines, IL-6 and IL-10 respectively, in cocaine users from a young population-based sample. This is a case-control study nested in a cross-sectional population-based survey, with individuals of 18 and 35 years old. Two groups were selected: 24 healthy controls and 12 subjects who reported cocaine use. Serum IL-6 and IL-10 were measured by ELISA using a commercial kit. There was a statistically significant increase in IL-6 (p=0.037) and decrease in IL-10 (p=0.007) serum levels, between cocaine users and the control group. There was also an increase in the ratio IL-6/IL-10 (p=0.013) among cocaine users individuals, when compared to the control group. Our results suggest that cocaine users showed an activation of the immune system when compared a control group, demonstrating a disruption in the balance of pro and antiinflammatory cytokines. Thus, peripheral cytokines may represent a putative biomarkers for cocaine users, contributing to the development of diagnosis and effective treatments. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  17. Castro en su territorio

    Directory of Open Access Journals (Sweden)

    Gonzalo Cerda Brintrup

    1988-06-01

    Full Text Available Su emplazamiento estaba dominado por sitios eriazos concentrándose las edificaciones más importantes en torno a la plaza (Iglesia, Convento, Edificios Públicos, Liceos y en calle Lillo, centro de la actividad comercial portuaria que, encaramadas sobre palafitos ponían un pie en el mar. Las grandes casonas de Lillo de dos y tres pisos con bodegas, locales comerciales, residenciales y hoteles serían reducidas a cenizas en el gran incendio de 1936.

  18. Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis.

    Science.gov (United States)

    Conti, Heather R; Whibley, Natasha; Coleman, Bianca M; Garg, Abhishek V; Jaycox, Jillian R; Gaffen, Sarah L

    2015-01-01

    Candida albicans is a commensal fungal microbe of the human orogastrointestinal tract and skin. C. albicans causes multiple forms of disease in immunocompromised patients, including oral, vaginal, dermal and disseminated candidiasis. The cytokine IL-17 (IL-17A) and its receptor subunits, IL-17RA and IL-17RC, are required for protection to most forms of candidiasis. The importance of the IL-17R pathway has been observed not only in knockout mouse models, but also in humans with rare genetic mutations that impact generation of Th17 cells or the IL-17 signaling pathway, including Hyper-IgE Syndrome (STAT3 or TYK2 mutations) or IL17RA or ACT1 gene deficiency. The IL-17 family of cytokines is a distinct subclass of cytokines with unique structural and signaling properties. IL-17A is the best-characterized member of the IL-17 family to date, but far less is known about other IL-17-related cytokines. In this study, we sought to determine the role of a related IL-17 cytokine, IL-17C, in protection against oral, dermal and disseminated forms of C. albicans infection. IL-17C signals through a heterodimeric receptor composed of the IL-17RA and IL-17RE subunits. We observed that IL-17C mRNA was induced following oral C. albicans infection. However, mice lacking IL-17C or IL-17RE cleared C. albicans infections in the oral mucosa, skin and bloodstream at rates similar to WT littermate controls. Moreover, these mice demonstrated similar gene transcription profiles and recovery kinetics as WT animals. These findings indicate that IL-17C and IL-17RE are dispensable for immunity to the forms of candidiasis evaluated, and illustrate a surprisingly limited specificity of the IL-17 family of cytokines with respect to systemic, oral and cutaneous Candida infections.

  19. IL-8 as antibody therapeutic target in inflammatory diseases

    DEFF Research Database (Denmark)

    Skov, Lone; Beurskens, Frank J; Zachariae, Claus O C

    2008-01-01

    IL-8 is a chemokine that has been implicated in a number of inflammatory diseases involving neutrophil activation. HuMab 10F8 is a novel fully human mAb against IL-8, which binds a discontinuous epitope on IL-8 overlapping the receptor binding site, and which effectively neutralizes IL-8-dependen...

  20. Il Rapporto Radcliff: e l'odierna politica monetaria inglese.

    Directory of Open Access Journals (Sweden)

    R.S. SAYERS

    2014-11-01

    Full Text Available Il saggio si occupa di tre principali argomenti ai quali il comitato ha dedicato tanta attenzione nel suo rapporto. Essi sono: il problema dell’informazione sulle questioni finanziarie, il controllo della quantità di moneta e la politica del tasso di interesse. C’è poi una breve sezione dedicata al problema costituzionale della posizione della banca centrale.

  1. Endogenous IL-10 protects mice from death during septic peritonitis

    NARCIS (Netherlands)

    van der Poll, T.; Marchant, A.; Buurman, W. A.; Berman, L.; Keogh, C. V.; Lazarus, D. D.; Nguyen, L.; Goldman, M.; Moldawer, L. L.; Lowry, S. F.

    1995-01-01

    IL-10 production during endotoxic shock is part of a protective mechanism that involves IL-10-induced inhibition of TNF synthesis. We sought to determine the role of IL-10 in septic peritonitis induced by cecal ligation and puncture (CLP). CLP led to a rapid induction of IL-10 mRNA in various organs

  2. Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort

    DEFF Research Database (Denmark)

    Larsen, Margit Hørup; Albrechtsen, Anders; Thørner, Lise Wegner

    2013-01-01

    Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectious and inflammatory diseases. This study aimed to find genetic variants that might affect the levels of LPS-induced interleukin (IL)-6, IL-8, IL-10, IL-1ra and tumor necrosis factor (TNF)-α cytokine production....

  3. Anti-IL-1alpha autoantibodies in early rheumatoid arthritis

    DEFF Research Database (Denmark)

    Forslind, K; Svensson, Birte; Svenson, M

    2001-01-01

    To investigate the potential predictive value of autoantibodies against IL1-alpha (anti-IL-1alpha) in patients with early rheumatoid arthritis (RA).......To investigate the potential predictive value of autoantibodies against IL1-alpha (anti-IL-1alpha) in patients with early rheumatoid arthritis (RA)....

  4. Le Nuove Scienze e il Genius Loci

    Directory of Open Access Journals (Sweden)

    Michael Mehaffy

    2009-12-01

    Full Text Available Oggi la teoria della conservazione urbana sta affrontando aspetti intangibili – notabilmente il concetto del “genius loci”. Ma questa idea potenzialmente vaga deve essere compresa nei termini che permettono un suo effettivo utilizzo. L’autore argomenta che tale questione può essere affrontata attraverso un approfondimento della complessità della scienza rivelando i modi attraverso i quali un sistema nella sua interezza può essere scomposto in elementi dinamici. All’interno dei tessuti storici noi siamo conservatori, siamo utilizzatori, siamo consumatori e, inevitabilmente, siamo coloro che attuano le modifiche. Il nostro compito non è di far resistere quell’insieme, ma di poterlo gestire in maniera più dinamica e di pretendere un più ampio concetto di conservazione. Questo atteggiamento va oltre il dualismo basato sul modello di pensiero del “genius loci” ma abbraccia una più efficace aspettativa di crescita organica.

  5. Il rumore elettrico Dalla fisica alla progettazione

    CERN Document Server

    Pallottino, Giovanni Vittorio

    2011-01-01

    L’opera fornisce una trattazione chiara, agile ed essenziale, ma completa, del rumore elettrico, argomento considerato generalmente oscuro e specialistico. Molto più breve (circa 275mila battute) dei testi attualmente disponibili. Il contenuto copre gli aspetti essenziali della matematica e della fisica del rumore (termico, shot. 1/f, …), e della sua rappresentazione nei circuiti. Discute quindi il rumore nei dispositivi passivi e attivi, e introduce i criteri di progettazione a basso rumore. Affronta infine brevemente questioni quali l’estrazione del segnale dal rumore e gli impieghi utili del rumore. L’attenzione è generalmente rivolta alla strumentazione fisica a bassa frequenza, in relazione alla pluridecennale esperienza specifica dell’autore. Si tratta di una estensione delle dispense, utilizzate per anni, di un corso universitario. Pertanto la trattazione è fortemente didattica, con particolare attenzione a rimuovere ambiguità e incertezze, discutendo il materiale in termini fisici intuit...

  6. Las disputas por los territorios en los albores del Estado nación: la frontera oriental de Corrientes durante la segunda mitad del siglo XIX

    Directory of Open Access Journals (Sweden)

    Raquel Valeria Bressan

    2017-01-01

    Full Text Available La organización del Estado nacional argentino implicó una significativa transformación de la forma en que los Estados provinciales habían configurado su territorio durante la primera mitad de siglo XIX a partir de la existencia de fronteras abiertas. Este artículo tiene como objetivo reconstruir las distintas posturas y argumentos que se pusieron en juego y que delinearon la definición de la configuración territorial de la provincia de Corrientes durante la segunda mitad del siglo XIX. Si bien las dirigencias correntinas no alcanzaron sus anhelos de incorporar la región de las Misiones bajo la jurisdicción provincial, el análisis de diversas fuentes permite evidenciar los puntos de tensión con respecto a cuál era la mejor forma de desarrollo para los territorios fronterizos y, a su vez, cómo el Congreso nacional se constituyó en un ámbito privilegiado para arbitrar las heterogéneas posturas políticas y determinar pautas de acción para los espacios disputados.

  7. Las temperaturas del territorio que se extiende desde el Cantábrico Oriental al Valle del Ebro durante el periodo internacional 1961-90

    Directory of Open Access Journals (Sweden)

    Javier M. Pejenaute Goñi

    2001-01-01

    Full Text Available El presente articulo tiene por objeto el estudio de las temperaturas en el territorio comprendido entre el Cantábrico oriental y el Valle del Ebro, durante el periodo internacional 1961-90. Este territorio está ocupado por las comunidades del País Vasco, Navarra, La Rioja y Aragón. Se estudian las temperaturas medias, las máximas, las mínimas, el coeficiente de variación y las heladas. También se incluye en el análisis anual, el estudio de la amplitud térmica, los quintiles y la tendencia futura.The present article aims at studying the temperatures in an área that goes from the cantábrico oriental and Valle del Ebro, for the international period of time going from 1961- 90. Four autonomous cornmunities. País Vasco, Navarra, La Rioja and Aragón, are included in this territory. The object of study will be the average, máximum and mínimum temperatures, as well as the coefficient of variation and freezes. It will also be included in the annual analysis. the study of thermal amplitude, quintiles, and future trend.

  8. Pensar los territorios del desarrollo: sustentabilidad y acción pública en nombre de una ciudad imaginaria. Concepción (Chile, 1950-2010

    Directory of Open Access Journals (Sweden)

    Enrique Aliste

    2014-05-01

    Full Text Available La discusión sobre el desarrollo pensado desde la noción de territorio se plantea acá como desafío central. Así, se exploran elementos que van otorgándole paulatinamente sustento a la noción de ciudad, sobre la base de los diferentes discursos del desarrollo hoy vigentes. Desde esta idea, se intenta problematizar la concepción de territorio en el ámbito de la acción pública, y se indaga en la forma en que, desde las prácticas discursivas, se articulan las prácticas espaciales que crean nuevas formas de organización y valoración espacial. Se concluye, para abrir una discusión más a largo plazo, que mirar la ciudad como objeto de planificación parece poco acertado, en tanto esta es más un proceso y una dinámica permanente que un ente estático, el cual geo-históricamente muestra tendencias y formas que adquieren sentido en el tiempo; y que, por lo mismo, se vuelve necesario mirar la ciudad en una perspectiva más amplia. Lo anterior se explora y analiza en el caso del Área Metropolitana de Concepción (AMC.

  9. Mecanismos de evaluación y seguimiento en planes de ordenación del territorio de Andalucía, España

    Directory of Open Access Journals (Sweden)

    Sergio Segura Calero

    2016-01-01

    Full Text Available Los mecanismos de evaluación y seguimiento de los planes de ordenación del territorio comprenden todos los procesos previstos y regulados en estos planes con la función de favorecer su evaluación, seguimiento y retroalimentación. En este trabajo se analizan los mecanismos que forman el sistema de seguimiento y evaluación de los planes de ordenación del territorio andaluces, como parte del sistema de gobernanza territorial de esta región meridional española, a partir del examen de los propios planes, la normativa vigente y aplicación de la misma por parte de los órganos competentes. Hasta qué punto su implementación hasta la fecha ha resultado exitosa en el caso de Andalucía también será objeto de análisis crítico, puesto que el desarrollo establecido, tanto en la normativa como en la práctica en esta materia, presenta algunas carencias y dificultades que se agravan por la limitación de recursos en el contexto de crisis económica actual.

  10. La ocupación del Territorio Nacional del Chaco: empresarios, agricultores y el rol de los expertos estatales (1926-1935

    Directory of Open Access Journals (Sweden)

    Adrián Alejandro Almirón

    2014-01-01

    Full Text Available La ocupación del Territorio Nacional del Chaco desde 1903 fue una tarea netamente estatal, a partir de esta responsabilidad se llevó a cabo la creación de distintas colonias y pueblos. La adjudicación de la tierra se realizaba a través de concesiones, en forma de permiso precario de ocupación o en arrendamiento; sin embargo, desde 1920 el proceso de poblamiento del Territorio Nacional fue frenético, los recién llegados se asentaron en la tierra que consideraban libre. Esto originó conflictos por la posesión del suelo dado que los colonos se ubicaban indiscriminadamente. El siguiente trabajo trata un conflicto por la posesión de la tierra, en donde fue indispensable la aparición de agentes estatales para determinar quien tenía derecho sobre el suelo. Se examinará a partir del conflicto entre la empresa la chaqueña y los ocupantes espontáneos o intrusos entre 1926 y 1935, el papel que tuvieron las inspecciones de tierras para resolver el litigio. Para la elaboración de este trabajo se utilizó como principal fuente documental las inspecciones de tierras y las resoluciones generadas por la Dirección General de Tierras para solucionar el conflicto.

  11. Territorialidades en transición: pobladores desplazados por la violencia del conflicto armado colombiano y la resignificación de su territorio

    Directory of Open Access Journals (Sweden)

    Myriam Ocampo Prado

    Full Text Available Resumen La violencia armada en Colombia obliga a las personas a abandonar su territorio para salvaguardar la vida. Cuatro estudios de caso con poblaciones desplazadas (mujeres jefas de hogar, afrodescendientes, indígenas, campesinos fueron emprendidos para aproximarse a la comprensión de dos procesos principales en los que se ven inmersos los migrantes forzados en búsqueda de superar la pérdida de su lugar en el mundo: desterritorialización y reterritorialización. La investigación mostró, entre las múltiples afectaciones que sobrevienen a estas personas, la dinámica de reconstrucción de un territorio para sí mismos que les exige adaptarse a condiciones de elevada precariedad en una espiral de pobreza y también de dependencia que los sujeta a la asistencia social y económica del Estado. Comprender el proceso que atraviesan involucra acercarse a una dimensión simbólica: significados y relación con el lugar de origen y con el lugar de reubicación; y una dimensión material: vivienda, trabajo, relaciones sociales y ocio.

  12. Think about and intervene in the territory through the Actor Network Theory Pensar e intervenir el territorio a traves de la Teoria del Actor-Red

    Directory of Open Access Journals (Sweden)

    Juan E. Cabrera

    2011-03-01

    Full Text Available The purpose of this article is to think about the similarities between the ways of seeing the territory as a network, some theoretical positions about the territory concept and actor network theory.
    After focusing on proposing a way of understanding the relationships between actors when they will intervene in the territory through the public policies and territorial planning, i ll try to apply the ANT model of public policy management through the guidance of ANT El propósito de este artículo es reflexionar sobre las coincidencias entre la forma de ver el territorio como red, algunas posturas teóricas sobre su concepto y la teoría del actor-red.
    Sobre lo anterior se centra en proponer una forma de entender las relaciones entre actores cuando se va a intervenir el territorio a través de políticas públicas como la planificación utilizando un modelo de gestión territorial a través de las orientaciones de la TAR.   

  13. La ruina de las capitales. A propósito de la incidencia del arte, los objetos ornamentales y el mobiliario urbano, en el espacio público, en el paisaje y en la configuración del territorio

    OpenAIRE

    Delgado Pérez, Germán J.

    2008-01-01

    De ruina de las capitales o de capitales de las ruinas, se podría calificar a muchas ciudades españolas. Arruinados, también, podrían considerarse los paisajes y los territorios de los términos municipales respectivos de esas ciudades, tras sufrir embates e intervenciones como los denominados «arte en la calle» o «arte en el espacio público». Gran parte del territorio nacional, se encuentra afectado por multitud de objetos-artefactos-mecanismos-esculturas-trastos-..., casi siempre innecesario...

  14. Relaciones entre sociedad y naturaleza. Usos del territorio patagónico chileno: La paradoja del medio natural. Modelamiento SIG de patrones de uso y antropización del medio natural.

    OpenAIRE

    Inostroza Pino, Luis

    2014-01-01

    La región de Magallanes, corazón de la Patagonia Chilena, es símbolo de un territorio prístino y virgen, inmaculado de la mano del hombre, poseedor de un sello de garantía ambiental. Sin embargo este territorio ha sido utilizado intensa y extensivamente durante el último siglo. La explotación ganadera ha transformado el ecosistema de estepas erosionando más del 60% de su superficie, mientras otras nuevas actividades aparecidas durante las últimas décadas como el turismo y la acuicultura so...

  15. IL17eScan: A Tool for the Identification of Peptides Inducing IL-17 Response

    Directory of Open Access Journals (Sweden)

    Sudheer Gupta

    2017-10-01

    Full Text Available IL-17 cytokines are pro-inflammatory cytokines and are crucial in host defense against various microbes. Induction of these cytokines by microbial antigens has been investigated in the case of ischemic brain injury, gingivitis, candidiasis, autoimmune myocarditis, etc. In this study, we have investigated the ability of amino acid sequence of antigens to induce IL-17 response using machine-learning approaches. A total of 338 IL-17-inducing and 984 IL-17 non-inducing peptides were retrieved from Immune Epitope Database. 80% of the data were randomly selected as training dataset and rest 20% as validation dataset. To predict the IL-17-inducing ability of peptides/protein antigens, different sequence-based machine-learning models were developed. The performance of support vector machine (SVM and random forest (RF was compared with different parameters to predict IL-17-inducing epitopes (IIEs. The dipeptide composition-based SVM-model displayed an accuracy of 82.4% with Matthews correlation coefficient = 0.62 at polynomial (t = 1 kernel on 10-fold cross-validation and outperformed RF. Amino acid residues Leu, Ser, Arg, Asn, and Phe and dipeptides LL, SL, LK, IL, LI, NL, LR, FK, SF, and LE are abundant in IIEs. The present tool helps in the identification of IIEs using machine-learning approaches. The induction of IL-17 plays an important role in several inflammatory diseases, and identification of such epitopes would be of great help to the immunologists. It is freely available at http://metagenomics.iiserb.ac.in/IL17eScan/ and http://metabiosys.iiserb.ac.in/IL17eScan/.

  16. Serum levels of interleukin-1 (IL-1α, IL-1β in patients with alopecia areata

    Directory of Open Access Journals (Sweden)

    Emina Kasumagić-Halilovic

    2012-07-01

    Full Text Available Introduction: Alopecia areata (AA is disease characterized by focally, nonscarring hair loss on the scalp or other parts of the body. It affects 1-2% population of both genders and occurs at all age groups. The etiology is unknown, although most evidence supports the hypothesis that AA is a T-cell-mediated autoimmune disease of the hair follicle and that cytokines play an important role.Objective: The aim of our study was to evaluate serum concentrations of IL-1α and IL-1β in patients with AA and healthy subjects and also to asses a possible association between these cytokines and duration of the disease.Methods: Forty six patients with AA and 20 healthy controls were enrolled in the study. Serum concentrations of IL-1α and IL-1β were measured using enzyme-linked immunoassay techniques.Results: The serum level of IL-1α in patients with AA was significantly higher than that in the control group (4.34±0.86 pg/mL vs 3.66±0.35 pg/mL, respectively. IL-1β levels were greater in patients with AA than in controls (2.35±0.17 pg/mL vs 2.24±0.30, respectively but the difference was not significant (p>0.05. No correlations were found between duration of disease and the serum levels of IL-1α and IL-1β.Conclusion: Our results have demonstrated the importance of determining IL-1a concentration in serum in patients with AA. This research could contribute to the interpretation of insufficiently well known views of the pathogenesis role and significance of IL-1α in AA.

  17. Expression of IL-8, IL-6 and IL-1β in Tears as a Main Characteristic of the Immune Response in Human Microbial Keratitis

    Science.gov (United States)

    Santacruz, Concepcion; Linares, Marisela; Garfias, Yonathan; Loustaunau, Luisa M.; Pavon, Lenin; Perez-Tapia, Sonia Mayra; Jimenez-Martinez, Maria C.

    2015-01-01

    Corneal infections are frequent and potentially vision-threatening diseases, and despite the significance of the immunological response in animal models of microbial keratitis (MK), it remains unclear in humans. The aim of this study was to describe the cytokine profile of tears in patients with MK. Characteristics of ocular lesions such as size of the epithelial defect, stromal infiltration, and hypopyon were analyzed. Immunological evaluation included determination of interleukine (IL)-1β, IL-6, IL-8, IL-10, IL-12 and tumor necrosis factor (TNF)-α in tear samples obtained from infected eyes of 28 patients with MK and compared with their contralateral non-infected eyes. Additionally, frequency of CD4+, CD8+, CD19+ and CD3−CD56+ cells was also determined in peripheral blood mononuclear cells in patients with MK, and compared with 48 healthy controls. Non-significant differences were observed in the size of the epithelial defect, stromal infiltration, and hypopyon. Nevertheless, we found an immunological profile apparently related to MK etiology. IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increased frequency of circulating CD3−CD56+ NK cells in patients with gram-negative keratitis; and IL-8 = IL-6 > IL-1β in patients with fungal keratitis. Characterization of tear cytokines from patients with MK could aid our understanding of the immune pathophysiological mechanisms underlying corneal damage in humans. PMID:25741769

  18. Studi d'idoneità ambientale su grande scala a fini conservazionistici: il caso del Capriolo italico nel P.N. del Pollino

    Directory of Open Access Journals (Sweden)

    Alessandro Massolo

    2003-10-01

    formulati hanno dato risultati soddisfacenti (> 70% di classificazioni corrette, ma alla verifica sui dati del PN del Pollino, solo il modello formulato con la regressione logistica e gli indici di paesaggio come variabili predittive, ha mostrato una potente capacità predittiva (89% degli avvistamenti e dei dati di presenza/assenza, classificando come idoneo per la specie circa il 59% del territorio del Parco. Il nostro studio suggerisce che vi sono casi in cui, nonostante le difficoltà insite nell?applicazione di un modello in aree differenti (soprattutto in termini di orografia e vegetazione da quella di origine dei dati, le caratteristiche di complessità e frammentazione del territorio a grande scala permettono la formulazione di un modello adeguato e potente. Infine, riteniamo che, senza un?adeguata valutazione su dati provenienti dall?area d?applicazione, le predizioni dei modelli possano dare risultati non coerenti con la distribuzione reale della popolazione in esame, suggerendo cautela nelle previsioni in aree in cui la specie sia assente.

  19. Playware e robotica modulare per il gioco

    Directory of Open Access Journals (Sweden)

    Henrik H. Lund

    2009-01-01

    Full Text Available In questo contributo presentiamo e usiamo il concetto di building block robotico per la creazione di playware. Il concetto tecnologico di building block programmabili e dotati di input e output (ivi inclusa la comunicazione e dell'intelligenza artificiale embodied, che enfatizza la relazione fra morfologia e controllo.Per dare un esempio concreto del concetto di building block robotico, proponiamo le mattonelle che abbiamo creato, come elementi che compongono un nuovo tipo di campo giochi sul quale i bambini possono sperimentare un feedback immediato ai loro movimenti.

  20. Recombinant human growth-regulated oncogene-alpha induces T lymphocyte chemotaxis. A process regulated via IL-8 receptors by IFN-gamma, TNF-alpha, IL-4, IL-10, and IL-13

    DEFF Research Database (Denmark)

    Jinquan, T; Frydenberg, Jane; Mukaida, N

    1995-01-01

    receptors on the cells. This process can be augmented by IFN-gamma and TNF-alpha, and inhibited by IL-4, IL-10, and IL-13. In addition, we also document that on T lymphocytes there exist IL-8 receptors that can be up-regulated by IFN-gamma, TNF-alpha, and IL-2. Our results demonstrate that rhGRO-alpha gene...

  1. DMPD: Differential responses of human monocytes and macrophages to IL-4 and IL-13. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 10534111 Differential responses of human monocytes and macrophages to IL-4 and IL-1...):575-8. (.png) (.svg) (.html) (.csml) Show Differential responses of human monocytes and macrophages to IL-...4 and IL-13. PubmedID 10534111 Title Differential responses of human monocytes an

  2. Giordano Bruno e il Problema della Modernita

    Directory of Open Access Journals (Sweden)

    Stefano Ulliana

    2005-08-01

    Full Text Available Il testo viene pubblicato per gentile concessione della casa editrice ESI ed e’ tratto dal libro di Stefano Ulliana “Il concetto creativo e dialettico dello Spirito nei Dialoghi Italiani di Giordano Bruno. Il confronto con la tradizione neoplatonico-aristotelica: il testo bruniano De l’Infinito, Universo e mondi”, Edizioni Scientifiche Italiane, Napoli, 2003. Le argomentazioni presentate ne Il concetto creativo e dialettico dello Spirito nei Dialoghi Italiani di Giordano Bruno (Il confronto con la tradizione neoplatonico-aristotelica: il testo bruniano De l’Infinito, Universo e mondi costituiscono le conclusioni ultime e definitive di un lavoro di ricerca che ha investito l’insieme dei Dialoghi Italiani, riuscendo a reperire ed a far emergere quello che pare il nucleo più profondo ed importante—il vero e proprio elevato fondamento—della speculazione bruniana: la presenza attiva di un concetto triadico teologico-politico—il Padre, il Figlio e lo Spirito della tradizione trinitaria cristiana—però riformulato attraverso il capovolgimento rivoluzionario di questa stessa tradizione, attuato attraverso il concetto creativo e dialettico dell’infinito. In questo modo la stessa tradizione platonica pare subire una trasformazione essenziale, abbandonando qualunque forma di alienazione e negazione, per riaprirsi invece verso soluzioni che paiono riprendere moniti ed osservazioni suscitati dalle prime, grandi e maestose, speculazioni dei filosofi presocratici. Parmenide, Eraclito ed Empedocle sembrano rivivere nei testi bruniani, riproponendo una soluzione ben diversa a quei nodi e problemi teoretico-pratici—fondamentale il rapporto Uno-molti e tutto ciò che da esso consegue, sia sul piano naturale che politico—apparentemente risolti e codificati dal pensiero postsocratico, prima platonico e poi aristotelico. L’inscindibilit� del principio di libert� (la figura teologica del Padre ed eguaglianza (il Figlio, attraverso

  3. Kineret®/IL-1ra blocks the IL-1/IL-8 inflammatory cascade during recombinant Panton Valentine Leukocidin-triggered pneumonia but not during S. aureus infection.

    Directory of Open Access Journals (Sweden)

    Delphine Labrousse

    Full Text Available OBJECTIVES: Community-acquired Staphylococcus aureus necrotizing pneumonia is a life-threatening disease. Panton Valentine Leukocidin (PVL has been associated with necrotizing pneumonia. PVL triggers inflammasome activation in human macrophages leading to IL-1β release. IL-1β activates lung epithelial cells to release IL-8. This study aimed to assess the relevance of this inflammatory cascade in vivo and to test the potential of an IL-1 receptor antagonist (IL-1Ra/Kineret to decrease inflammation-mediated lung injury. METHODS: We used the sequential instillation of Heat-killed S. aureus and PVL or S. aureus infection to trigger necrotizing pneumonia in rabbits. In these models, we investigated inflammation in the presence or absence of IL-1Ra/Kineret. RESULTS: We demonstrated that the presence of PVL was associated with IL-1β and IL-8 release in the lung. During PVL-mediated sterile pneumonia, Kineret/IL-1Ra reduced IL-8 production indicating the relevance of the PVL/IL-1/IL-8 cascade in vivo and the potential of Kineret/IL-1Ra to reduce lung inflammation. However, Kineret/IL-1Ra was ineffective in blocking IL-8 production during infection with S. aureus. Furthermore, treatment with Kineret increased the bacterial burden in the lung. CONCLUSIONS: Our data demonstrate PVL-dependent inflammasome activation during S.aureus pneumonia, indicate that IL-1 signaling controls bacterial burden in the lung and suggest that therapy aimed at targeting this pathway might be deleterious during pneumonia.

  4. Supervising and leading teams in ILS

    CERN Document Server

    Allan, Barbara

    2013-01-01

    Provides a practical guide to supervisory skills, suitable for team leaders and supervisors in library and information work. Illustrated by examples and case studies from different types of ILS, this book offers self-assessment audits and other activities to enable the reader to relate the tools and techniques to their own work situation.

  5. IL TERREMOTO JONICO DEL 22 APRILE 1948

    Directory of Open Access Journals (Sweden)

    p. Valle

    1951-06-01

    Full Text Available Allo scopo di contribuire alla localizzazione dei centri sismiciche interessano l'Italia e per essere in jtossesso dei dati fondamentaliper una successiva ricerca, sono state calcolate le coordinate epicentralie il tempo origine del terremoto Jonico del 22 aprile 1948.

  6. Il progetto Virgo, Einstein e i computer

    CERN Document Server

    2003-01-01

    "Virgo sta accendendo i suoi laser: mercoledi e stato inaugurato a Pisa il piu potente rivelatore di onde gravitazionali al mondo, capace eventualmente di segnalare l'arrivo di un'onda dal cosmo, con una sensibilita di un miliardesimo di miliardesimo di metro" (1/2 page)

  7. Il significato della relatività

    CERN Document Server

    Einstein, Albert

    1955-01-01

    La prima edizione di questo libro, pubblicata bel 1922, comprendeva il testo delle Stafford Little Lectures tenute da Einstein nel maggio 1921 alla Università di Princeton. Nel 1945 Einstein aggiunse un'appendice sulla sua teoria generalizzata della gravitazione. Nel 1953 Einstein rifece del tutto, ampliandola, la seconda appendice, a cui aggiunse un Supplemento nel 1954.

  8. IL-2 absorption affects IFN-gamma and IL-5, but not IL-4 producing memory T cells in double color cytokine ELISPOT assays.

    Science.gov (United States)

    Quast, Stefan; Zhang, Wenji; Shive, Carey; Kovalovski, Damian; Ott, Patrick A; Herzog, Bernhard A; Boehm, Bernhard O; Tary-Lehmann, Magdalena; Karulin, Alexey Y; Lehmann, Paul V

    2005-09-01

    Cytokine assays are gaining increasing importance for human immune monitoring because they reliably detect antigen-specific T cells in primary PBMC, even at low clonal sizes. Double color ELISPOT assays permit the simultaneous visualization of cells producing two different cytokines. Permitting the simultaneous assessment of type 1 and 2 immunity and due to the limited numbers of PBMC available from human study subjects, double color assays should be particularly attractive for clinical trials. Since the performance of double color assays has not yet been validated, we set out to compare them to single color measurements. Testing the recall antigen-induced cytokine response of PBMC, we found that double color assays regularly provided lower numbers of IFN-gamma and IL-5 spots than single color measurements when IL-2 detection was part of the double color assay. We showed that the inhibitory effect resulted from IL-2 absorption and could be overcome by either antibody free preactivation cultures or by inclusion of anti-CD28 antibody. In contrast, the simultaneous detection of IL-2 did not affect the numbers of IL-4 spots. Therefore, unlike IL-2/IL-4 and IFN-gamma/IL-5 assays, IL-2/IFN-gamma, and IL-2/IL-5 assays require compensation for the IL-2 capture to provide accurate numbers for the frequencies of cytokine producing memory T cells.

  9. Polymorphisms of the IL-6, IL-8 and IL-10 genes and the risk of gastric pathology in patients infected with Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Ivy Bastos Ramis

    2017-04-01

    Conclusion: We demonstrated that polymorphisms in the IL-8 gene was significantly associated with H. pylori infection. Furthermore, polymorphisms in the IL-8 and IL-10 genes were associated with an enhanced risk of peptic ulcer disease in H. pylori-positive patients.

  10. GeoCallCenter: quando il GIS entra in simbiosi con il telefono

    Directory of Open Access Journals (Sweden)

    Ivan Tani

    2007-03-01

    illuminazione e delle reti semaforiche. L’idea di un SIT di holding prende corpo nel 2003 con l’obiettivo di costituire un punto di coordinamento nel gestire in maniera omogenea l’informazione geografica e gli applicativi per il trattamento delle medesime, per tutto il gruppo. Il progetto eredita i livelli funzionali e la struttura trasparente del precedente SIT di Seabo S.p.A., in cui aspetti territoriali, ambientali, di gestione, di pianificazione e di servizio al cliente sono stati considerati contestualmente allo sviluppo complessivo del sistema informativo aziendale.

  11. Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis.

    Directory of Open Access Journals (Sweden)

    Christian Lundtoft

    2017-06-01

    Full Text Available T-cell proliferation and generation of protective memory during chronic infections depend on Interleukin-7 (IL-7 availability and receptivity. Regulation of IL-7 receptor (IL-7R expression and signalling are key for IL-7-modulated T-cell functions. Aberrant expression of soluble (s and membrane-associated (m IL-7R molecules is associated with development of autoimmunity and immune failure in acquired immune deficiency syndrome (AIDS patients. Here we investigated the role of IL-7/IL-7R on T-cell immunity in human tuberculosis. We performed two independent case-control studies comparing tuberculosis patients and healthy contacts. This was combined with follow-up examinations for a subgroup of tuberculosis patients under therapy and recovery. Blood plasma and T cells were characterised for IL-7/sIL-7R and mIL-7R expression, respectively. IL-7-dependent T-cell functions were determined by analysing STAT5 phosphorylation, antigen-specific cytokine release and by analysing markers of T-cell exhaustion and inflammation. Tuberculosis patients had lower soluble IL-7R (p < 0.001 and higher IL-7 (p < 0.001 plasma concentrations as compared to healthy contacts. Both markers were largely independent and aberrant expression normalised during therapy and recovery. Furthermore, tuberculosis patients had lower levels of mIL-7R in T cells caused by post-transcriptional mechanisms. Functional in vitro tests indicated diminished IL-7-induced STAT5 phosphorylation and impaired IL-7-promoted cytokine release of Mycobacterium tuberculosis-specific CD4+ T cells from tuberculosis patients. Finally, we determined T-cell exhaustion markers PD-1 and SOCS3 and detected increased SOCS3 expression during therapy. Only moderate correlation of PD-1 and SOCS3 with IL-7 expression was observed. We conclude that diminished soluble IL-7R and increased IL-7 plasma concentrations, as well as decreased membrane-associated IL-7R expression in T cells, reflect impaired T

  12. Fasting induces IL-1 resistance and free fatty acid-mediated up-regulation of IL-1R2 and IL-1RA

    Directory of Open Access Journals (Sweden)

    jenifer j joesting

    2014-07-01

    Full Text Available Objective: Weight loss is a near societal obsession and many diet programs use significant calorie restriction (CR including fasting/short term starvation to generate rapid effects. Fasting is also a well-recognized cause of immunosuppression especially within the innate immune system. In this study, we sought to determine if the IL-1 arm of the neuroimmune system was down-regulated by a 24 hr fast and how fasting might generate this effect. Design: Mice were allowed ad libitum access to food or had food withheld for 24 hrs. Expression of the endogenous IL-1 antagonists IL-1 receptor type 2 (IL-1R2 and IL-1 receptor antagonist (IL-1RA were determined as were sickness behaviors before and after IL-1 administration.Results: Fasting markedly increased gene expression of IL-1R2 (83-fold in adipose tissue, 9.5-fold in liver and IL-1RA (68-fold in liver. Fasted mice were protected from IL-1-induced weight loss, hypoglycemia, loss of locomotor and social anxiety. These protections were coupled to a large positive interaction of fasting and IL-1 on IL-1R2 gene expression in adipose tissue and liver (2.6-fold and 1.6-fold, respectively. Fasting not only increased IL-1RA and IL-1R2 protein 2.5-fold and 3.2-fold, respectively, in liver; but also increased IL-1R2 1.8-fold in adipose tissue. Fasting, in turn, triggered a 2.4-fold increase in plasma free-fatty acids (FFAs and a 2.1-fold increase in plasma corticosterone. Inhibition, of glucocorticoid action with mifepristone did not impact fasting-dependent IL-1R2 or IL-1RA gene expression. Administration of the FFA, palmitate, to mice increased liver IL-1R2 and IL-1RA gene expression by 14-fold and 11-fold, respectively. Conclusion: These findings indicate that fasting augments expression of endogenous IL-1 antagonists inducing IL-1 resistance. Fasting-induced increases in plasma FFAs appears to be a signal that drives immunosuppression during fasting/short term starvation.

  13. Rappresentare il progetto di interaction Design

    Directory of Open Access Journals (Sweden)

    Michele Zannoni

    2013-03-01

    Full Text Available ItQuesto saggio indaga le conseguenze che, nel mutato contesto del progetto contemporaneo del design, implica la forte convergenza della disciplina del progetto nei temi legati all'interaction design. L'evidenza di questo mutamento mette in luce come nell'iter progettuale il ruolo centrico del disegno e della rappresentazione è messo in crisi da una trasformazione dei contenuti del progetto. Il rapporto tra il progetto dell'interfaccia e il product design, la dematerializzazione dei feedback tattili e visivi, la sempre più diffusa digitalizzazione delle superfici di interazione degli oggetti, mostrano come il design del prodotto non è immune alla trasformazione che ha cambiato i media della comunicazione negli ultimi dieci anni e gli strumenti della rappresentazione si devono adeguare per poter prefigurare una sempre maggior complessità del percorso progettuale.EnIn the changing context of contemporary design, this essay explores the consequences entailed by the significant convergence of the discipline of design towards the themes relative to action design. The evidence of this change highlights how the central role of drawing and representation in the design process is challenged by the transformation in the contents of design. The relationship between the design of the interface and product design, the dematerialization of tactile and visual feedback, the increasingly widespread digitalization of the interaction surfaces of objects, prove that product design is not immune to the transformation that has changed communication media over the past ten years and the tools of representation must adapt to maintain the capacity to prefigure the growing complexity of the design process.

  14. Vaghezza e chiarezza: tradurre Il grande Gatsby

    Directory of Open Access Journals (Sweden)

    Franca Cavagnoli

    2014-05-01

    Full Text Available La traduzione di The Great Gatsby (1925 di Francis Scott Fitzgerald, pubblicata da Feltrinelli nel 2011: dalla tensione fra lingua scritta e lingua orale all’alternarsi di registri linguistici assai vari nei dialoghi (formale, colloquiale, popolare, dalla difficoltà di seguire Fitzgerald nelle sue ellissi all’aderenza sia alle sue scelte stilistiche sia ai campi espressivi da lui prediletti, in particolare l’area semantica del mare, delle tenebre, dell’inquietudine. Nell’articolo entro nel dettaglio delle singole scelte traduttive – attraverso il confronto della traduzione con il testo fonte e la spiegazione delle decisioni prese – compiute all’insegna di una scelta di fondo, e cioè che il fine etico dell’atto traduttivo sia accogliere lo Straniero in quanto tale, affinché nel versare un libro nella propria lingua madre l’Altro resti Altro e il desiderio di tradurre non porti a sostituire il proprio all’altrui. The article retraces the path I followed in my translation, published by Feltrinelli in 2011, of Francis Scott Fitzgerald’s The Great Gatsby (1925 – from the tension between the written and spoken languages to the wide diversity of registers (formal, colloquial, popular in the dialogues, from the difficulty of staying in step with Fitzgerald’s ellipses to the preservation of his stylistic choices and his favourite semantic fields, particularly those of the sea, of darkness and of restlessness. By comparing my translation with the source text and explaining the rationale behind my decisions, I will perform a thorough examination of my translation choices, which have been based on the tenet that the ethical aim of the translation act is to receive the Foreign as Foreign, so that when one turns a book into one’s own mother tongue the Other remains the Other and the wish to translate does not lead one to replace the Other with the Self.  

  15. IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome

    Directory of Open Access Journals (Sweden)

    Shujuan Li

    2012-01-01

    Full Text Available Guillain-Barré syndrome (GBS is an acute autoimmune-mediated inflammatory demyelinating disease that causes rapidly progressing paralysis and occasionally respiratory failure. We hypothesized that interleukin (IL-17 and IL-22 are elevated in GBS and participate in the autoimmune inflammatory response of GBS. We used sandwich enzyme-linked immunosorbent assay (ELISA to measure the IL-17 and IL-22 levels in the CSF, and plasma from 22 GBS patients at the acute phase and 18 healthy controls (HC. The results show that CSF and plasma levels of IL-17 and IL-22 are elevated in GBS patients compared with HC. IL-17 and IL-22 levels in CSF, respectively, are correlated with GBS disability scale scores (GDSs. Meanwhile, IL-17 and IL-22 levels in CSF, IL-22 in CSF, and plasma of GBS patients have positive correlation, respectively. The increased levels of IL-17 and IL-22 in CSF may be explained by the disruption of blood-brain barrier (BBB and peripheral nervous system (PNS local inflammation in GBS. Meanwhile, the elevated levels of these two cytokines in plasma suggest the activation of Th17 and Th22 cells in the systemic immune response of GBS. Our data provide preliminary evidence that GBS is associated with high levels of IL-17 and IL-22 in CSF and plasma. These cytokines display pathogenic potential and may serve as useful biomarkers for GBS.

  16. IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

    Science.gov (United States)

    Mitchell, Ruth E; Hassan, Masriana; Burton, Bronwen R; Britton, Graham; Hill, Elaine V; Verhagen, Johan; Wraith, David C

    2017-09-12

    IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4 + T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 production by a chronically stimulated antigen-specific population of differentiated Th1 cells. In vitro, IL-4 blockade inhibited while addition of exogenous IL-4 to Th1 cultures enhanced IL-10 production. In the in vivo setting of peptide immunotherapy leading to a chronically stimulated Th1 phenotype, lack of IL-4Rα inhibited the induction of IL-10. Exploring the interplay of Th1 and Th2 cells through co-culture, Th2-derived IL-4 promoted IL-10 expression by Th1 cultures, reducing their pathogenicity in vivo. Co-culture led to upregulated c-Maf expression with no decrease in the proportion of T-bet + cells in these cultures. Addition of IL-4 also reduced the encephalitogenic capacity of Th1 cultures. These data demonstrate that IL-4 contributes to IL-10 production and that Th2 cells modulate Th1 cultures towards a self-regulatory phenotype, contributing to the cross-regulation of Th1 and Th2 cells. These findings are important in the context of Th1 driven diseases since they reveal how the Th1 phenotype and function can be modulated by IL-4.

  17. The role of IL-33 in rheumatic diseases.

    Science.gov (United States)

    Duan, Lihua; Chen, Jie; Gong, Feili; Shi, Guixiu

    2013-01-01

    Interleukin-33 (IL-33), a novel member of IL-1 family, has been recently implicated in several inflammatory and autoimmune diseases. IL-33 can be produced by various types of tissues and cells and induce gene expression of Th2-associated cytokines via binding to the orphan receptor ST2. By promoting Th2 type immune response, IL-33 plays important roles in the allergy, whereas its function in autoimmune diseases attracts more attention. Recent studies reported the correlation of IL-33 with rheumatic diseases, and most of them found that the IL-33 expression levels were consistent with disease activity and development. Furthermore, evidence has indicated that IL-33-related treatment may ameliorate the pathogenic conditions and attenuate disease progression of those rheumatic diseases. Therefore, elucidation of the roles of IL-33 in rheumatic diseases would be beneficial to understand the pathogenesis and therapy of these diseases. In this paper, we will summarize the roles of IL-33 in the rheumatic diseases.

  18. Factors Associated With Plasma IL-6 Levels During HIV Infection

    DEFF Research Database (Denmark)

    Borges, Álvaro H; O'Connor, Jemma L; Phillips, Andrew N

    2015-01-01

    BACKGROUND: Elevated interleukin 6 (IL-6) levels have been linked to cardiovascular disease, cancer and death. Persons with human immunodeficiency virus (HIV) infection receiving treatment have higher IL-6 levels, but few data are available on factors associated with circulating IL-6. METHODS......: Participants in 3 trials with IL-6 measured at baseline were included (N = 9864). Factors associated with IL-6 were identified by linear regression. Demographic and HIV variables (nadir/entry CD4(+) cell count, HIV RNA level, antiretroviral therapy regimen) were investigated in all 3 trials. In the SMART...... education, whereas black race was associated with lower IL-6. Higher HIV RNA levels were associated with higher IL-6 levels, and higher nadir CD4(+) cell counts with lower IL-6 levels. Compared with efavirenz, protease inhibitors were associated with higher and nevirapine with lower IL-6 levels. Smoking...

  19. Effects of cranberry components on IL-1β-stimulated production of IL-6, IL-8 and VEGF by human TMJ synovial fibroblasts.

    Science.gov (United States)

    Tipton, David A; Christian, James; Blumer, Adam

    2016-08-01

    Osteoarthritis (OA) in the TMJ is characterized by deterioration of articular cartilage and secondary inflammatory changes. Interleukin-1β (IL-1β) stimulates IL-6, IL-8, and vascular endothelial growth factor (VEGF) in synovial fluid of TMJ with internal derangement and bony changes. The cranberry (Vaccinium macrocarpon) contains polyphenolic compounds that inhibit production of pro-inflammatory molecules by gingival cells in response to several stimulators. This study examined effects of cranberry components on IL-1β-stimulated IL-6, IL-8, and VEGF production by human TMJ synovial fibroblast-like cells. Cranberry high molecular weight non-dialyzable material (NDM) was derived from cranberry juice. Human TMJ synovial fibroblast-like cells from joints with degenerative OA and an ankylosed TMJ without degeneration were incubated with IL-1β (0.001-1nM)±NDM (25-250μg/ml) (2h preincubation). Viability was assessed via activity of a mitochondrial enzyme. IL-6, IL-8, and VEGF in culture supernatants were measured by ELISA; NF-κB and AP-1 transcription factors were measured in nuclear extracts via binding to specific oligonucleotides. ANOVA and Scheffe's F procedure for post hoc comparisons. NDM did not affect cell viability but inhibited IL-1β stimulated IL-6, IL-8, and VEGF production in all cell lines (pCranberry NDM inhibition of IL-1β-stimulated IL- 6, IL-8, and VEGF production by TMJ synovial fibroblast-like cells suggests that cranberry components may be useful as a host modulatory therapeutic agent to prevent or treat inflammatory arthropathies of the TMJ. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation during Clostridium difficile colitis in mice.

    Science.gov (United States)

    McDermott, Andrew J; Falkowski, Nicole R; McDonald, Roderick A; Pandit, Chinmay R; Young, Vincent B; Huffnagle, Gary B

    2016-01-01

    Our objective was to determine the role of the inflammatory cytokine interleukin-23 (IL-23) in promoting neutrophil recruitment, inflammatory cytokine expression and intestinal histopathology in response to Clostridium difficile infection. Wild-type (WT) and p19(-/-) (IL-23KO) mice were pre-treated with cefoperazone in their drinking water for 5 days, and after a 2-day recovery period were challenged with spores from C. difficile strain VPI 10463. Interleukin-23 deficiency was associated with significant defects in both the recruitment of CD11b(High) Ly6G(H) (igh) neutrophils to the colon and the expression of neutrophil chemoattractants and stabilization factors including Cxcl1, Cxcl2, Ccl3 and Csf3 within the colonic mucosa as compared with WT animals. Furthermore, the expression of inflammatory cytokines including Il33, Tnf and Il6 was significantly reduced in IL-23-deficient animals. There was also a trend towards less severe colonic histopathology in the absence of IL-23. The induction of Il17a and Il22 was also significantly abrogated in IL-23KO mice. Inflammatory cytokine expression and neutrophilic inflammation were not reduced in IL-17a-deficient mice or in mice treated with anti-IL-22 depleting monoclonal antibody. However, induction of RegIIIg was significantly reduced in animals treated with anti-IL-22 antibody. Taken together, these data indicate that IL-23, but not IL-17a or IL-22, promotes neutrophil recruitment and inflammatory cytokine and chemokine expression in the colon in response to C. difficile infection. © 2015 John Wiley & Sons Ltd.

  1. Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interactions between tumor cells and stromal fibroblasts through IL-1α in ameloblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Fuchigami, Takao [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Kibe, Toshiro [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Koyama, Hirofumi; Kishida, Shosei; Iijima, Mikio [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Nishizawa, Yoshiaki [Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Hijioka, Hiroshi; Fujii, Tomomi [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Ueda, Masahiro [Natural Science Centre for Research and Education, Kagoshima University, 1-21-24 Koorimoto, Kagoshima 890-8580 (Japan); Nakamura, Norifumi [Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Kiyono, Tohru [Department of Virology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuouku, Tokyo 104-0045 (Japan); Kishida, Michiko, E-mail: kmichiko@m2.kufm.kagoshima-u.ac.jp [Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan)

    2014-09-05

    Highlights: • We studied the interaction between tumor cells and fibroblasts in ameloblastoma. • AM-3 ameloblastoma cells secreted significantly high IL-1α levels. • IL-1α derived from AM-3 cells promoted IL-6 and IL-8 secretion of fibroblasts. • IL-6 and IL-8 activated the cellular motility and proliferation of AM-3 cells. - Abstract: Ameloblastoma is an odontogenic benign tumor that occurs in the jawbone, which invades bone and reoccurs locally. This tumor is treated by wide surgical excision and causes various problems, including changes in facial countenance and mastication disorders. Ameloblastomas have abundant tumor stroma, including fibroblasts and immune cells. Although cell-to-cell interactions are considered to be involved in the pathogenesis of many diseases, intercellular communications in ameloblastoma have not been fully investigated. In this study, we examined interactions between tumor cells and stromal fibroblasts via soluble factors in ameloblastoma. We used a human ameloblastoma cell line (AM-3 ameloblastoma cells), human fibroblasts (HFF-2 fibroblasts), and primary-cultured fibroblasts from human ameloblastoma tissues, and analyzed the effect of ameloblastoma-associated cell-to-cell communications on gene expression, cytokine secretion, cellular motility and proliferation. AM-3 ameloblastoma cells secreted higher levels of interleukin (IL)-1α than HFF-2 fibroblasts. Treatment with conditioned medium from AM-3 ameloblastoma cells upregulated gene expression and secretion of IL-6 and IL-8 of HFF-2 fibroblasts and primary-cultured fibroblast cells from ameloblastoma tissues. The AM3-stimulated production of IL-6 and IL-8 in fibroblasts was neutralized by pretreatment of AM-3 cells with anti-IL-1α antibody and IL-1 receptor antagonist. Reciprocally, cellular motility of AM-3 ameloblastoma cells was stimulated by HFF-2 fibroblasts in IL-6 and IL-8 dependent manner. In conclusion, ameloblastoma cells and stromal fibroblasts behave

  2. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    International Nuclear Information System (INIS)

    Forward, Nicholas A.; Conrad, David M.; Power Coombs, Melanie R.; Doucette, Carolyn D.; Furlong, Suzanne J.; Lin, Tong-Jun; Hoskin, David W.

    2011-01-01

    Highlights: → Curcumin inhibits CD4 + T-lymphocyte proliferation. → Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4 + T-lymphocytes. → Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. → IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4 + T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (α chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca 2+ release to inhibit IκB phosphorylation, which is required for nuclear translocation of the transcription factor NFκB. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4 + CD25 + regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  3. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    Energy Technology Data Exchange (ETDEWEB)

    Forward, Nicholas A.; Conrad, David M. [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Power Coombs, Melanie R.; Doucette, Carolyn D. [Department of Pathology, Dalhousie University, Halifax, Nova Scotia (Canada); Furlong, Suzanne J. [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Lin, Tong-Jun [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia (Canada); Hoskin, David W., E-mail: d.w.hoskin@dal.ca [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Pathology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Surgery, Dalhousie University, Halifax, Nova Scotia (Canada)

    2011-04-22

    Highlights: {yields} Curcumin inhibits CD4{sup +} T-lymphocyte proliferation. {yields} Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4{sup +} T-lymphocytes. {yields} Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. {yields} IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4{sup +} T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 ({alpha} chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca{sup 2+} release to inhibit I{kappa}B phosphorylation, which is required for nuclear translocation of the transcription factor NF{kappa}B. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4{sup +}CD25{sup +} regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  4. Conflictos territoriales en la comunidad indígena de Sikilta. Territorio: Mayangna Sauni Bas. Municipio de Siuna, RAAN. Período 2007

    Directory of Open Access Journals (Sweden)

    Hedley Lucio Díaz Gutiérrez

    2012-09-01

    Full Text Available La presente investigación fue efectuada en el territorio: Mayangna Sauni Bas [número tres], enfocada hacia el conflicto entre la comunidad indígena de Sikilta y las comunidades de Kupahwas, Lawas y Toro Waslalita que se ubican dentro de la reserva de biósfera de BOSAWAS. Considerando que este trabajo alertará a las autoridades municipales, regionales y nacionales sobre la urgencia de ponerle fin a esta problemática.El objetivo central fue analizar los conflictos que se han ocasionado dentro de este territorio, sus causas y consecuencias, el marco jurídico sobre la tierra, territorio y valorar el papel que han jugado las instituciones gubernamentales y no gubernamentales en este problema. Esta investigación es cualitativa con un enfoque etnográfico, utilizando las principales prácticas antropológicas: observación participativa, entrevistas formales e informales y grupo focal con las autoridades. Las conversaciones con los miembros de la comunidad de Sikilta y de comunidades vecinas, permitieron verificar la información oral. Para las entrevistas con los colonos mestizos se empleó el idioma español y para la comunidad de Sikilta, se utilizó la lengua sumu- mayangna.Entre los principales hallazgos se encuentra: el desplazamiento de familias mestizas ubicadas en el Occidente y Norte de Nicaragua en busca de una tierra fértil, y que solamente los pueblos indígenas poseen, mientras la zona de los colonos es un desierto degradado sin producción, generando en una de las causa de los conflictos por tierra. Consecuencia de ello es el peligro de extinción de la cosmovisión de los pueblos indígenas, su cultura y su administración que ancestralmente han conservado y protegido. Los suelos están degradados, los ríos han bajado su nivel que ancestralmente han mantenido. Para la actividad de la caza los comunitarios cada vez se alejan hacia las profundidades del bosque para poder obtener carne de animales silvestres. Los indígenas de

  5. LA INTEGRACIÓN EN FUNCIÓN DEL DESARROLLO LOCAL SOSTENIBLE: GESTIÓN DEL CONOCIMIENTO DESDE LA UNIVERSIDAD HACIA EL TERRITORIO DEL MUNICIPIO CAMAJUANÍ EN CUBA.

    Directory of Open Access Journals (Sweden)

    CARLOS ALBERTO HERNÁNDEZ MEDINA

    2011-12-01

    Full Text Available Se realizó una experiencia de Gestión del Conocimiento desde el Centro Universitario Municipal (CUM hacia el territorio de Camajuaní. La actividad del CUM realiza una contribución efectiva a la construcción y funcionamiento de una Red Local para la Gestión del Conocimiento y la Innovación en Camajuaní, de cara a las necesidades sociales. A partir del diagnóstico participativo inicial se determinaron las principales necesidades del territorio concentradas en producción de alimentos, materiales de construcción y vivienda, desarrollo de Industria Local, capacitación e Informatización, Agua y Energía. Se documenta una experiencia de Producción de Alimentos en las Cooperativas campesinas con implementación de los Programas: Conservación y rehabilitación de suelos, Protección de la biodiversidad, Conservación de alimentos, Educación ambiental, capacitación en la comunidad y formación de promotores “Campesino a Campesino”. El uso de tecnologías agroecológicas en las Cooperativas campesinas marcó el inicio de su desarrollo económico y ecológico sustentable. Las fincas hoy muestran un uso más intensivo y sostenible de la tierra expresado en el número de especies manejadas y mayor contenido de materia orgánica. El campesino mejora la producción, sus condiciones económico - sociales y gana en calidad de vida. Cambiamos patrones dominantes de producción y consumo que contribuían al deterioro ambiental recuperando la diversidad biológica y la calidad de los ecosistemas. Se crearon condiciones para un equilibrio entre desarrollo comunitario y protección de la biosfera. Se demostró que la lentitud con que en el territorio se habían introducido las tecnologías agroecológicas obedecía a factores Culturales, Educativos, Sociales y Económicos

  6. Territorio, recursos turísticos y capacidad de carga. Una interpretación teórica del caso de la isla de Lanzarote

    Directory of Open Access Journals (Sweden)

    Santiago Hernández Torres

    2013-10-01

    Full Text Available La presente investigación propone una interpretación sobre un aspecto relevante en el actual desarrollo de los espacios turísticos. Esta cuestión presenta implicaciones sociales y económicas, y está referida a las relaciones entre los distintos agentes que intervienen en el territorio. Dichas relaciones se asocian, a su vez, a las transformaciones en los recursos turísticos del espacio y su capacidad de carga. Se intenta profundizar en los aspectos teóricos y factores que intervienen en este último indicador como criterio fundamental para la cualificación del territorio como soporte del turismo en Canarias. Apoyado en una metodología de inventario exhaustivo de los aspectos geográficos y los recursos turísticos, se delimitan los indicadores de sostenibilidad, a partir de los que se extrae un modelo crítico de valoración e interpretación de la capacidad de acogida del turismo. De este modo, se utiliza el ejemplo de la isla de Lanzarote como laboratorio adecuado a tal fin; poniendo sobre la mesa algunos planteamientos asociados al desarrollo de la planificación del territorio como instrumento para el desarrollo del turismo.This research proposes an exercise in interpreting an important aspect of the present social and economic development of tourist areas, referring to the relations established by the different stakeholders involved in the region, between the region, its tourist resources and the so-called carrying capacity. An attempt is made to gain greater insight into the conceptual aspects and factors that have an impact on this latter indicator as a fundamental programmed criterion for zoning the area as a foundation for tourism in the Canary Islands. Based on a methodology of an exhaustive inventory of all elements that could be considered as tourist resources, sustainability indicators are identified as a starting point for developing a critical model for evaluating and interpreting the capacity of an area for receiving

  7. Nación y territorio: la dimensión simbólica del espacio en la construcción nacional argentina. Siglo XIX

    Directory of Open Access Journals (Sweden)

    Quijada, Mónica

    2000-08-01

    Full Text Available This article studies the links between the symbolical dimension of the territory and ethnic interaction in Argentina during the 19th Century. The analysis focuses on the theoretical assumptions of the interaction between nation and territory in the framework of the «civic» model assumed by the Spanish American Republics; the consolidation of a territorial ideology implying the unification and integration –both symbolical and physical– of the national space; the symbolic dimension of a concept –«desert»– in the framework of the Argentinian national building process; and finally the treatment of ethnic diversity which aimed at homogeneizing the indigenous, African and immigrant elements at the imaginary level, on the basis of «territory» as the main principle of integration.

    En este artículo se estudia la vinculación entre la dimensión simbólica del territorio y las formas de tratamiento de la interacción étnica en la Argentina, a lo largo del siglo XIX. Los principales puntos del análisis son la dimensión teórica de la interacción entre nación y territorio en el marco del modelo de «nación cívica» que fue propio de los procesos de edificación de las repúblicas hispanoamericanas; la consolidación de una ideología territorial que implicó la unificación e integración del espacio nacional en su percepción tanto simbólica como física; la carga simbólica de la noción de «desierto» en el marco de la construcción nacional argentina, y finalmente las formas de tratamiento de la diversidad étnica que implicó la homogeneización en el imaginario de los componentes indígena, africano e inmigratorio a partir del territorio como elemento básico de la integración.

  8. The interleukin (IL)-23/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment.

    Science.gov (United States)

    Jethwa, H; Bowness, P

    2016-01-01

    Ankylosing spondylitis (AS), the most common form of spondyloarthropathy, is a chronic, progressive multi-system inflammatory disorder characteristically affecting the sacroiliac joints and axial skeleton. Although the exact mechanisms underlying the pathogenesis of AS remain to be elucidated, the presence of human leucocyte antigen (HLA)-B27 is known to markedly increase its risk of development. Current treatments include non-steroidal anti-inflammatory drugs (NSAIDs) and tumour necrosis factor (TNF) blockers. In recent years, the interleukin (IL)-23/IL-17 pathway has been shown to have significance in the pathogenesis of AS and treatment modalities targeting this pathway have been shown to be beneficial in various other inflammatory conditions. This review provides an overview of the IL-23/IL-17 pathway in the pathogenesis of AS and summarizes new potential treatments for AS and related inflammatory diseases. © 2015 British Society for Immunology.

  9. MODELO DE EVALUACIÓN DE LA CAPACIDAD DE ACOGIDA DEL TERRITORIO CON SIG Y TÉCNICAS DE DECISIÓN MULTICRITERIO RESPECTO A LA IMPLANTACIÓN DE EDIFICACIONES EN ESPACIOS RURALES

    Directory of Open Access Journals (Sweden)

    Federico Benjamín Galacho Jiménez

    2013-01-01

    Full Text Available Se muestra un método, que apoyado en propuestas científicas, ayuda en la planificación del uso sostenible del territorio. Dicho método se basa en los modelos de evaluación de la capacidad de acogida del territorio. Su fundamento es el desarrollo de una metodología de evaluación con una perspectiva amplia de la sostenibilidad rural y contempla la necesaria puesta en valor de los recursos naturales, la preservación del medio por su calidad ambiental y la minimización de los riesgos naturales. Con él se evaluará la implantación de edificaciones relacionadas con el proceso de urbanización difusa en los espacios rurales. Para ello se aborda la evaluación de las condiciones particulares del medio rural en orden a la mejor estimación de sus posibilidades y de su vulnerabilidad respecto a los riesgos naturales. Como resultado se ha realizado una evaluación basada en juicios de valor claramente definidos y en atributos concretos del territorio. Mediante este proceso se obtiene una capa de información que muestra una clasificación del espacio estudiado con una valoración asignada a cada parte del territorio en función de su capacidad para acoger los usos que han sido evaluados.

  10. Distribución de veinticuatro plantas termófilas mediterráneas en el territorio de la cuenca del Omecillo, Valderejo y Sobrón (Alava-Burgos

    Directory of Open Access Journals (Sweden)

    Juan José Barredo, Unai Barredo López de Alda

    2004-01-01

    Full Text Available Se aporta corología y ecología para veinticuatro plantas termófilas mediterráneas en la cuenca del Omecillo y Sobrón, ocho de las cuales constituyen novedad en dicho territorio, y se adjuntan dos mapas.

  11. Serum concentration of IL-6, IL-2, TNF-α, and IFNγ in Vitiligo patients

    Directory of Open Access Journals (Sweden)

    Suman Singh

    2012-01-01

    Full Text Available Background: Vitiligo is an acquired depigmenting disorder characterized by the loss of functional melanocytes from the epidermis. Although the etiology of vitiligo is unknown, over the last few years, substantial data from clinical research has greatly supported the ′Autoimmune theory′ and this is supported by the frequent association of vitiligo with disorders that have an autoimmune origin, including Hashimoto′s thyroiditis, Graves disease, type 1 insulin-dependent diabetes mellitus, and Addison′s disease. As cytokines are important mediators of immunity, there is evidence to suggest that they play a major role in the pathogenesis of autoimmune diseases. Aim: Keeping this in view we have assayed sera for cytokine IL-6, IL-2, Tumor necrosis factor (TNF-α, and IFNγ in 80 cases of vitiligo and compared it with healthy subjects, in order to find out whether they play a role in the pathogenesis of vitiligo or not. Materials and Methods: Serum IL-6, IL-2, TNF-α, and IFNγ were done by the indirect enzyme linked immunosorbent assay (ELISA. Results: The mean serum IL-6 and IL-2 levels in the patient group were significantly higher when compared with those of the normal controls. The mean serum IFNγ level in patients with vitiligo was significantly lower than that in the control group. There was no significant difference in the serum level of TNF-α between vitiligo and healthy controls. Conclusion : An increase in the production of proinflammatory cytokines such as IL-6 and IL-2 in vitiligo patients may play an important role in melanocytic cytotoxicity. Thus, we speculate that the cytokine production of epidermal microenvironment may be involved in vitiligo.

  12. IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment.

    Science.gov (United States)

    Leone, Amanda; Picker, Louis J; Sodora, Donald L

    2009-01-01

    While highly active antiretroviral therapy (HAART) regimens have proven to be effective in controlling active HIV replication, complete recovery of CD4+ T cells does not always occur, even among patients with high level virologic control. Recent advances in understanding the biology of T cell production and homeostasis have created the potential to augment anti-viral therapies with immunotherapies designed to facilitate recovery of the HIV-damaged immune system, in particular, the recovery of CD4+ T cell populations. The common gamma-chain cytokines IL-2, IL-7 and IL-15 are primary regulators of T cell homeostasis and thus have been considered prime candidate immunotherapeutics, both for increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. Recent studies have established that these cytokines have distinct functional roles in immune homeostasis, which focus on specific T cell populations. The ability of these cytokines to provide immunotherapeutic benefit to HIV+ patients will depend on their ability to stably increase or functionally enhance the desired T cell target population without adverse virologic or clinical consequences.

  13. An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target.

    Science.gov (United States)

    Mahil, Satveer K; Catapano, Marika; Di Meglio, Paola; Dand, Nick; Ahlfors, Helena; Carr, Ian M; Smith, Catherine H; Trembath, Richard C; Peakman, Mark; Wright, John; Ciccarelli, Francesca D; Barker, Jonathan N; Capon, Francesca

    2017-10-11

    Interleukin (IL)-36α, IL-36β, and IL-36γ are innate mediators of acute epithelial inflammation. We sought to demonstrate that these cytokines are also required for the pathogenesis of plaque psoriasis, a common and chronic skin disorder, caused by abnormal T helper 17 (T H 17) cell activation. To investigate this possibility, we first defined the genes that are induced by IL-36 cytokines in primary human keratinocytes. This enabled us to demonstrate a significant IL-36 signature among the transcripts that are up-regulated in plaque psoriasis and the susceptibility loci associated with the disease in genome-wide studies. Next, we investigated the impact of in vivo and ex vivo IL-36 receptor blockade using a neutralizing antibody or a recombinant antagonist. Both inhibitors had marked anti-inflammatory effects on psoriatic skin, demonstrated by statistically significant reductions in IL-17 expression, keratinocyte activation, and leukocyte infiltration. Finally, we explored the potential safety profile associated with IL-36 blockade by phenotyping 12 individuals carrying knockout mutations of the IL-36 receptor gene. We found that normal immune function was broadly preserved in these individuals, suggesting that IL-36 signaling inhibition would not substantially compromise host defenses. These observations, which integrate the results of transcriptomics and model system analysis, pave the way for early-stage clinical trials of IL-36 antagonists. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  14. The effects of IL-10 gene polymorphism on serum, and gingival crevicular fluid levels of IL-6 and IL-10 in chronic periodontitis.

    Science.gov (United States)

    Toker, Hulya; Gorgun, Emine Pirim; Korkmaz, Ertan Mahir; Yüce, Hatice Balci; Poyraz, Omer

    2018-01-01

    Anti-inflammatory cytokines play a crucial role in periodontitis by inhibiting synthesis of pro-inflammatory cytokines. The purpose of this study was to evaluate the effect of interleukin-10 (-597) gene polymorphism and genotype distributions on chronic periodontitis (CP) development and IL-6 and IL-10 levels in gingival crevicular fluid (GCF) and serum before and after non-surgical periodontal treatment. The study population consisted of 55 severe generalized CP patients as CP group and 50 healthy individuals as control group. Plaque index, gingival index, probing depth and clinical attachment level were recorded and GCF and blood samples were taken at both the baseline and the sixth week after non-surgical periodontal treatment. PCR-RFLP procedure was used for gene analyses and cytokine levels were measured via ELISA. IL-10 genotype distribution was significantly different between CP and control groups (p=0.000, OR:7, 95%CI, 2.83-60.25). Clinical measurements significantly improved in the CP group after periodontal treatment (p0.05). Sixth week GCF IL-10 levels were significantly lower in patients carrying IL-10 AC+CC genotype compared to the patients carrying IL-10 AA genotype (p0.05). IL-10 AA genotype carriers had lower IL-6 and IL-6/10 levels in serum; however, GCF IL-6/10 levels were similar in both genotypes. Within the limitations of our study, a possible association between IL-10(-597) gene polymorphism and CP might be considered.

  15. Preparation and validation of radio iodinated recombinant human IL-10 for the measurement of natural human antibodies against IL-10

    DEFF Research Database (Denmark)

    de Lemos Rieper, Carina; Galle, Pia; Svenson, Morten

    2009-01-01

    Radio iodinated recombinant human IL-10 was prepared and validated for the measurement of natural human anti-IL-10 antibodies. Iodination of IL-10 was accomplished by means of the chloramine-T method. The crude tracer was purified by size chromatography as homo-dimeric IL-10 with a specific...... activity of 75 cpm/pg. Validation of the tracer confirmed preserved antibody epitopes and receptor binding ability. A robust Radio Immuno Assay (RIA) was developed and validated to detect natural human anti-IL-10 antibodies based on the formation of (125)I-labeled IL-10-IgG complexes in solution...... and separation of the complexes by chromatography on mini-columns. The RIA was applied to 3360 plasma samples derived from normal Danish blood donors. Generally, IL-10 did not bind to plasma factors other than natural anti-IL-10 IgG antibodies. The prevalence of donors high positive for antibodies against IL-10...

  16. Il potenziale informativo degli archivi di fotografia militare della Seconda Guerra Mondiale ai fini della protezione civile e dell’analisi del territorio Fotogrammetria, intelligenza artificiale e webGIS al servizio degli archivi fotografici

    Directory of Open Access Journals (Sweden)

    Elizabeth Jane Shepherd

    2018-01-01

    unexploded ordnance (UXO, still retrieved on a nearly daily basis. The AFN collection is a powerful, though still underdeveloped record of the landscape of wartime Italy and is essential for the plotting of UXO hazard maps. The article focuses on the main steps to be taken in order to exploit and share it.

  17. L’utilizzo dei sensori di vibrazione per il monitoraggio delle frane e la salvaguardia del territorio - On the use of ground vibration sensors for landslide monitoring and land conservation

    Directory of Open Access Journals (Sweden)

    Massimo Arattano

    2015-10-01

    Full Text Available I sensori sismici ed acustici sembrano mostrare promettenti possibilità di utilizzo per la mitigazione del rischio da frana. Recenti ricerche sul M.te Cervino, ad esempio, hanno utilizzato reti microsismiche per individuare le sedi di crolli potenziali e per stabilire la relazione tra variazioni di temperatura ed emissioni acustiche in roccia. È invece attualmente in fase di sperimentazione l’utilizzo di sensori geofonici e sismometri per la realizzazione di innovativi sistemi di allarme per colate detritiche, capaci di rilevarne l’arrivo con un significativo margine di tempo di anticipo. Nell’articolo vengono illustrati e discussi in dettaglio alcuni esempi applicativi. ------ Seismic and acoustic sensors seem to show promising possibilities of employment for the mitigation of landslide hazards. Recent researches carried out on the Matterhorn, as an example, have used microseismic networks to locate potential areas of rockfalls and to establish a relationship between temperature variations and acoustic emissions in rocks. It is currently under investigation, instead, the use of geophone sensors and seismometers for the realization of innovative warning systems for debris flows, capable to detect their arrival with a significant amount of time in advance. In this article some practical examples will be presented and discussed in detail.

  18. UN PROGETTO DI TERRITORIO PER IL TURISMO SOSTENIBILE L’ESPERIENZA DI RICERCA APPLICATA DEL PISL “SLOW LIFE. VIAGGIO TRA CULTURE E NATURA NEL PARCO NAZIONALE D'ASPROMONTE, DAL TRE PIZZI AL LIMINA”

    Directory of Open Access Journals (Sweden)

    Raffaella Campanella

    2015-06-01

    Full Text Available Issues about the protection, enhancement, promotion of environmental resources have been for a long time the basis of a method of approach to a 'form' of territorial project based on strategies for local development focused on fruition of tourist in historical, cultural, heritage places and landscape. But if on the one hand tourism is a possible device to revitalize local economies in crisis, at the same time in many cases it tends to accentuate the degradation and the loss of identity of these places during the last years. Arises, therefore, the need to reverse this process and to overcome the idea of cultural heritage and landscape conceived as a commodity, and reaffirm the right to the city territories-landscapes to be areas of social life. You need to identify new design procedures able to impact on local systems and at the same time to enter into relationships with global networks, transforming specific values in local values recognizable and globally recognized using local significances to express global meanings.

  19. The early IL-6 and IL-10 response in trauma is correlated with injury severity and mortality

    DEFF Research Database (Denmark)

    Stensballe, J; Christiansen, M; Tønnesen, E

    2009-01-01

    BACKGROUND: Trauma has previously been shown to influence interleukin (IL)-6 and IL-10 levels, but the association of injury severity and mortality with IL-6 and IL-10 responses in the early phase of accidental trauma remains to be investigated. We wished to describe serum levels of IL-6 and IL-10...... period. Serum levels of IL-6 and IL-10 were measured upon arrival and at 6, 12, and 24 h after admittance using an enzyme-linked immunosorbent assay. Correlation analysis was used to assess the relationship between Injury Severity Score (ISS) and levels of IL-6 and IL-10. Analysis of variance was used...... to describe the IL-6 and IL-10 concentrations in relation to 30-day mortality in a mixed-effect model repeated measures analysis. RESULTS: Mortality was 10.9% (29/265) at 30 days. A significant increase of both IL-6 and IL-10 concentrations was found over time, and a significant correlation was found between...

  20. IL-4 Modulates CCL11 and CCL20 Productions from IL-1β-Stimulated Human Periodontal Ligament Cells

    Directory of Open Access Journals (Sweden)

    Yoshitaka Hosokawa

    2016-01-01

    Full Text Available Background/Aims: IL-4 is a multifunctional cytokine that is related with the pathological conditions of periodontal disease. However, it is uncertain whether IL-4 could control T cells migration in periodontal lesions. The aim of this study was to examine the effects of IL-4 on CCL11, which is a Th2-type chemokine, and CCL20, which is related with Th17 cells migration, productions from human periodontal ligament cells (HPDLCs. Methods: CCL20 and CCL11 productions from HPDLCs were monitored by ELISA. Western blot analysis was performed to detect phosphorylations of signal transduction molecules in HPDLCs. Results: IL-1β could induce both CCL11 and CCL20 productions in HPDLCs. IL-4 enhanced CCL11 productions from IL-1β-stimulated HPDLCs, though IL-4 inhibited CCL20 production. Western blot analysis showed that protein kinase B (Akt and signal transducer and activator of transcription (STAT6 pathways were highly activated in IL-4/IL-1β-stimulated HPDLCs. Akt and STAT6 inhibitors decreased CCL11 production, but enhanced CCL20 production in HPDLCs stimulated with IL-4 and IL-1β. Conclusions: These results mean that IL-4 enhanced Th2 cells migration in periodontal lesion to induce CCL11 production from HPDLCs. On the other hand, IL-4 inhibits Th17 cells accumulation in periodontally diseased tissues to inhibit CCL20 production. Therefore, IL-4 is positively related with the pathogenesis of periodontal disease to control chemokine productions in periodontal lesions.