Food restriction alters energy allocation strategy during growth in tobacco hornworms (Manduca sexta larvae).

Science.gov (United States)

Jiao, Lihong; Amunugama, Kaushalya; Hayes, Matthew B; Jennings, Michael; Domingo, Azriel; Hou, Chen

2015-08-01

Growing animals must alter their energy budget in the face of environmental changes and prioritize the energy allocation to metabolism for life-sustaining requirements and energy deposition in new biomass growth. We hypothesize that when food availability is low, larvae of holometabolic insects with a short development stage (relative to the low food availability period) prioritize biomass growth at the expense of metabolism. Driven by this hypothesis, we develop a simple theoretical model, based on conservation of energy and allometric scaling laws, for understanding the dynamic energy budget of growing larvae under food restriction. We test the hypothesis by manipulative experiments on fifth instar hornworms at three temperatures. At each temperature, food restriction increases the scaling power of growth rate but decreases that of metabolic rate, as predicted by the hypothesis. During the fifth instar, the energy budgets of larvae change dynamically. The free-feeding larvae slightly decrease the energy allocated to growth as body mass increases and increase the energy allocated to life sustaining. The opposite trends were observed in food restricted larvae, indicating the predicted prioritization in the energy budget under food restriction. We compare the energy budgets of a few endothermic and ectothermic species and discuss how different life histories lead to the differences in the energy budgets under food restriction.

Intermittent energy restriction in type 2 diabetes: A short discussion of medication management.

Science.gov (United States)

Carter, Sharayah; Clifton, Peter M; Keogh, Jennifer B

2016-12-15

To discuss type 2 diabetes mellitus (T2DM) medication changes required during the popular 5:2 intermittent energy restriction (IER) diet. A search was conducted in MEDLINE, EMBASE, AMED, CINAHL and Cochrane library for original research articles investigating the use of very low calorie diets (VLCD) in people with T2DM. The search terms used included "VLCD" or "very low energy diet" or "very low energy restriction" or "IER" or "intermittent fasting" or "calorie restriction" or "diabetes mellitus type 2" and "type 2 diabetes". Reference lists of selected articles were also screened for relevant publications. Only research articles written in English, which also included an explanation of medication changes were included. A recent pilot trial using the 5:2 IER method, conducted by our research group, will also be summarized. A total of 8 studies were found that investigated the use of VLCD in T2DM and discussed medication management. Overall these studies indicate that the use of a VLCD for people with T2DM usually require the cessation of medication to prevent hypoglycemia. Therefore, the 5:2 IER method will also require medication changes, but as seen in our pilot trial, may not require total cessation of medication, rather a cessation on the 2 IER days only. Guidelines outlined here can be used in the initial stages of a 2-d IER diet, but extensive blood glucose monitoring is still required to make the necessary individual reductions to medications in response to weight loss.

Verbal Short-Term Memory Span in Children: Long-Term Modality Dependent Effects of Intrauterine Growth Restriction

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Geva, R.; Eshel, R.; Leitner, Y.; Fattal-Valevski, A.; Harel, S.

2008-01-01

Background: Recent reports showed that children born with intrauterine growth restriction (IUGR) are at greater risk of experiencing verbal short-term memory span (STM) deficits that may impede their learning capacities at school. It is still unknown whether these deficits are modality dependent. Methods: This long-term, prospective design study…

Leptin responsiveness to energy restriction: genetic variation in the leptin receptor gene.

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Mars, Monica; van Rossum, Caroline T M; de Graaf, Cees; Hoebee, Barbara; De Groot, Lisette C P G M; Kok, Frans J

2004-03-01

Serum leptin concentrations are an important afferent signal in energy balance homeostasis. It has been speculated that the leptin responsiveness to energy restriction is affected by the functionality of the leptin receptor. The purpose of this analysis was to explore the effect of polymorphisms in the LEPR gene on the acute decline in leptin after 4 days of 65% energy restriction. Leptin concentrations of the study group (n = 44; all men) declined by 2.3 +/- 1.5 micro g/L [-39.4% (95% confidence interval: -43.6 to -34.9)]. Leptin responses did not statistically differ between noncarriers and carriers of three mutant variants of the polymorphisms: Lys109/Lys109 (-41.4%) vs. Arg109/+ (-37.0%) (p = 0.33); Gln223/Gln223 (-41.5%) vs. Arg223/+ (-37.8%) (p = 0.40); Lys656/Lys656 (-39.5%) vs. Asn656/+ (-39.3%) (p = 0.96). No effect of the assessed polymorphisms in the LEPR gene on the acute decline in leptin after energy restriction was observed. Power calculations are provided for future studies on the leptin responsiveness to energy restriction.

Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice.

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Mitchell, James R; Verweij, Mariëlle; Brand, Karl; van de Ven, Marieke; Goemaere, Natascha; van den Engel, Sandra; Chu, Timothy; Forrer, Flavio; Müller, Cristina; de Jong, Marion; van IJcken, Wilfred; IJzermans, Jan N M; Hoeijmakers, Jan H J; de Bruin, Ron W F

2010-02-01

Dietary restriction (DR) extends lifespan and increases resistance to multiple forms of stress, including ischemia reperfusion injury to the brain and heart in rodents. While maximal effects on lifespan require long-term restriction, the kinetics of onset of benefits against acute stress is not known. Here, we show that 2-4 weeks of 30% DR improved survival and kidney function following renal ischemia reperfusion injury in mice. Brief periods of water-only fasting were similarly effective at protecting against ischemic damage. Significant protection occurred within 1 day, persisted for several days beyond the fasting period and extended to another organ, the liver. Protection by both short-term DR and fasting correlated with improved insulin sensitivity, increased expression of markers of antioxidant defense and reduced expression of markers of inflammation and insulin/insulin-like growth factor-1 signaling. Unbiased transcriptional profiling of kidneys from mice subject to short-term DR or fasting revealed a significant enrichment of signature genes of long-term DR. These data demonstrate that brief periods of reduced food intake, including short-term daily restriction and fasting, can increase resistance to ischemia reperfusion injury in rodents and suggest a rapid onset of benefits of DR in mammals.

Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

NARCIS (Netherlands)

J.R. Mitchell (James); M. Verweij (Marielle); K. Brand (Karl); H.W.M. van de Ven (Marieke); N.N.T. Goemaere (Natascha); S. van den Engel (Sandra); T. Chu (Timothy); F. Forrer (Flavio); C. Müller (Cristina); M. de Jong (Marion); W.F.J. van IJcken (Wilfred); J.N.M. IJzermans (Jan); J.H.J. Hoeijmakers (Jan); R.W.F. de Bruin (Ron)

2010-01-01

textabstractDietary restriction (DR) extends lifespan and increases resistance to multiple forms of stress, including ischemia reperfusion injury to the brain and heart in rodents. While maximal effects on lifespan require long-term restriction, the kinetics of onset of benefits against acute stress

One day of moderate energy deficit reduces fasting and postprandial triacylglycerolemia in women: the role of calorie restriction and exercise.

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Maraki, Maria; Magkos, Faidon; Christodoulou, Nektarios; Aggelopoulou, Niki; Skenderi, Katerina P; Panagiotakos, Demosthenes; Kavouras, Stavros A; Sidossis, Labros S

2010-08-01

Fasting and postprandial hypertriacylglycerolemia are important cardiovascular risk factors in women. We sought to examine the effects of acute (1 day), moderate ( approximately 2 MJ) energy deficit induced by calorie restriction, exercise, or combination of both on fasting and postprandial triacylglycerol (TAG) metabolism in women. Six healthy premenopausal women performed four oral fat tolerance tests in the morning after a day of a) rest (control), b) calorie restriction ( approximately 2 MJ), c) exercise (net deficit of approximately 2 MJ) and d) calorie restriction-plus-exercise (total energy deficit of approximately 2 MJ). All energy deficit trials significantly reduced fasting and postprandial total plasma TAG concentrations by 15-23% and 12-23%, respectively, and triacylglycerol-rich lipoprotein TAG concentrations by 37-43% and 25-39%, respectively, compared with the control condition (Pwomen. Exercise elicits a somewhat greater effect than calorie restriction in the postprandial state. The acute effect of diet and exercise should be taken into account when studying the long-term effects of weight loss and exercise training on TAG metabolism. Copyright 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice.

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Radhika V Seimon

Full Text Available Intermittent severe energy restriction is popular for weight management. To investigate whether intermittent moderate energy restriction may improve this approach by enhancing weight loss efficiency, we conducted a study in mice, where energy intake can be controlled.Male C57/Bl6 mice that had been rendered obese by an ad libitum diet high in fat and sugar for 22 weeks were then fed one of two energy-restricted normal chow diets for a 12-week weight loss phase. The continuous diet (CD provided 82% of the energy intake of age-matched ad libitum chow-fed controls. The intermittent diet (ID provided cycles of 82% of control intake for 5-6 consecutive days, and ad libitum intake for 1-3 days. Weight loss efficiency during this phase was calculated as (total weight change ÷ [(total energy intake of mice on CD or ID-(total average energy intake of controls]. Subsets of mice then underwent a 3-week weight regain phase involving ad libitum re-feeding.Mice on the ID showed transient hyperphagia relative to controls during each 1-3-day ad libitum feeding period, and overall ate significantly more than CD mice (91.1±1.0 versus 82.2±0.5% of control intake respectively, n = 10, P<0.05. There were no significant differences between CD and ID groups at the end of the weight loss or weight regain phases with respect to body weight, fat mass, circulating glucose or insulin concentrations, or the insulin resistance index. Weight loss efficiency was significantly greater with ID than with CD (0.042±0.007 versus 0.018±0.001 g/kJ, n = 10, P<0.01. Mice on the CD exhibited significantly greater hypothalamic mRNA expression of proopiomelanocortin (POMC relative to ID and control mice, with no differences in neuropeptide Y or agouti-related peptide mRNA expression between energy-restricted groups.Intermittent moderate energy restriction may offer an advantage over continuous moderate energy restriction, because it induces significantly greater weight loss relative

Effect of 24-h severe energy restriction on appetite regulation and ad libitum energy intake in lean men and women.

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Clayton, David J; Burrell, Kirsty; Mynott, Georgina; Creese, Mark; Skidmore, Nicola; Stensel, David J; James, Lewis J

2016-12-01

Intermittent severe energy restriction (SER) can induce substantial weight loss, but the appetite regulatory responses to SER are unknown and may dictate long-term dietary adherence. We determined the effect of 24-h SER on appetite regulation, metabolism, and energy intake. Eighteen lean men and women completed two 3-d trials in randomized, counterbalanced order. On day 1 subjects consumed standardized diets containing 100% (mean ± SD: 9.3 ± 1.3 MJ; energy balance) or 25% [2.3 ± 0.3 MJ; energy restriction (ER)] of energy requirements. On day 2, a standardized breakfast was consumed, with plasma concentrations of acylated ghrelin, glucagon-like peptide 1, insulin, glucose, and nonesterified fatty acids determined for 4 h. Ad libitum energy intake was assessed at lunch and dinner with subjective appetite and resting metabolism assessed throughout. On day 3, ad libitum energy intake was assessed at breakfast and by weighed food records. Energy intake was 7% greater on day 2 (P 0.145). During ER, postprandial concentrations of acylated ghrelin were lower (P < 0.05), whereas glucose (P < 0.05) and nonesterified fatty acids (P < 0.0001) were higher. Postprandial glucagon-like peptide 1 7-36 (P = 0.784) and insulin (P = 0.06) concentrations were not significantly different between trials. Energy expenditure was lower during ER in the morning (P < 0.01). In lean young adults, 24-h SER transiently elevated subjective appetite and marginally increased energy intake, but hormonal appetite markers did not respond in a manner indicative of hyperphagia. These results suggest that intermittent SER might be useful to attenuate energy intake and control body weight in this population. This trial was registered at www.clinicaltrials.gov.uk as NCT02696772. © 2016 American Society for Nutrition.

Short-Term Preoperative Calorie and Protein Restriction Is Feasible in Healthy Kidney Donors and Morbidly Obese Patients Scheduled for Surgery

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Franny Jongbloed

2016-05-01

Full Text Available Introduction. Surgery-induced oxidative stress increases the risk of perioperative complications and delay in postoperative recovery. In mice, short-term preoperative dietary and protein restriction protect against oxidative stress. We investigated the feasibility of a calorie- and protein-restricted diet in two patient populations. Methods. In this pilot study, 30 live kidney donors and 38 morbidly obese patients awaiting surgery were randomized into three groups: a restricted diet group, who received a synthetic liquid diet with 30% fewer calories and 80% less protein for five consecutive days; a group who received a synthetic diet containing the daily energy requirements (DER; and a control group. Feasibility was assessed using self-reported discomfort, body weight changes, and metabolic parameters in blood samples. Results. Twenty patients (71% complied with the restricted and 13 (65% with the DER-diet. In total, 68% of the patients reported minor discomfort that resolved after normal eating resumed. The mean weight loss on the restricted diet was significantly greater (2.4 kg than in the control group (0 kg, p = 0.002, but not in the DER-diet (1.5 kg. The restricted diet significantly reduced levels of serum urea and plasma prealbumin (PAB and retinol binding protein (RBP. Conclusions. A short-term preoperative calorie- and protein-restricted diet is feasible in kidney donors and morbidly obese patients. Compliance is high and can be objectively measured via changes in urea, PAB, and RBP levels. These results demonstrate that this diet can be used to study the effects of dietary restriction on surgery-induced oxidative stress in a clinical setting.

Protein-pacing caloric-restriction enhances body composition similarly in obese men and women during weight loss and sustains efficacy during long-term weight maintenance

DEFF Research Database (Denmark)

Arciero, Paul J; Edmonds, Rohan; He, Feng

2016-01-01

Short-Term protein-pacing (P; ~6 meals/day, >30% protein/day) and caloric restriction (CR, ~25% energy deficit) improves total (TBF), abdominal (ABF) and visceral (VAT) fat loss, energy expenditure, and biomarkers compared to heart healthy (HH) recommendations (3 meals/day, 15% protein/day) in ob......Short-Term protein-pacing (P; ~6 meals/day, >30% protein/day) and caloric restriction (CR, ~25% energy deficit) improves total (TBF), abdominal (ABF) and visceral (VAT) fat loss, energy expenditure, and biomarkers compared to heart healthy (HH) recommendations (3 meals/day, 15% protein....../day) in obese adults. Less is known whether obese men and women respond similarly to P-CR during weight loss (WL) and whether a modified P-CR (mP-CR) is more efficacious than a HH diet during long-term (52 week) weight maintenance (WM). The purposes of this study were to evaluate the efficacy of: (1) P......-CR on TBF, ABF, resting metabolic rate (RMR), and biomarkers between obese men and women during WL (weeks 0-12); and (2) mP-CR compared to a HH diet during WM (weeks 13-64). During WL, men (n = 21) and women (n = 19) were assessed for TBF, ABF, VAT, RMR, and biomarkers at weeks 0 (pre) and 12 (post). Men...

Compensatory mechanisms activated with intermittent energy restriction: A randomized control trial.

Science.gov (United States)

Coutinho, Sílvia Ribeiro; Halset, Eline Holli; Gåsbakk, Sigrid; Rehfeld, Jens F; Kulseng, Bård; Truby, Helen; Martins, Cátia

2018-06-01

Strong compensatory responses, with reduced resting metabolic rate (RMR), increased exercise efficiency (ExEff) and appetite, are activated when weight loss (WL) is achieved with continuous energy restriction (CER), which try to restore energy balance. Intermittent energy restriction (IER), where short spells of energy restriction are interspaced by periods of habitual energy intake, may offer some protection in minimizing those responses. We aimed to compare the effect of IER versus CER on body composition and the compensatory responses induced by WL. 35 adults (age: 39 ± 9 y) with obesity (BMI: 36 ± 4 kg/m 2 ) were randomized to lose a similar weight with an IER (N = 18) or a CER (N = 17) diet over a 12 week period. Macronutrient composition and overall energy restriction (33% reduction) were similar between groups. Body weight/composition, RMR, fasting respiratory quotient (RQ), ExEff (10, 25, and 50 W), subjective appetite ratings (hunger, fullness, desire to eat, and prospective food consumption (PFC)), and appetite-regulating hormones (active ghrelin (AG), cholecystokinin (CCK), total peptide YY (PYY), active glucagon-like peptide-1 (GLP-1), and insulin) were measured before and after WL. Changes in body weight (≈12.5% WL) and composition were similar in both groups. Fasting RQ and ExEff at 10 W increased in both groups. Losing weight, either by IER or CER dieting, did not induce significant changes in subjective appetite ratings. RMR decreased and ExEff at 25 and 50 W increased (P intermittent, does not appear to modulate the compensatory mechanisms activated by weight loss. NCT02169778 (the study was registered in clinicaltrial.gov). Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

High intake of dairy during energy restriction does not affect energy balance or the intestinal microflora compared to low dairy intake in overweight individuals in a randomized controlled trial

DEFF Research Database (Denmark)

Bendtsen, Line Quist; Blædel, Trine; Holm, Jacob Bak

2018-01-01

During weight loss, dairy calcium is proposed to accelerate weight and fat mass loss through increased fecal fat excretion. The primary objective was to investigate if a high-dairy energy-restricted diet is superior to low-dairy in terms of changes in body weight, body composition and fecal fat...... excretion over 24 weeks. Secondary objectives included fecal energy and calcium excretion, resting energy expenditure, blood pressure, lipid metabolism and gut microbiota. In a randomized, parallel-arm intervention study 11 men and 69 women (BMI 30.60.3 kg/m2, age 441 years) were allocated to a 500 kcal...... not increase fecal fat or accelerate weight and fat mass loss beyond energy restriction over 24 weeks in overweight and obese adults with a habitual calcium intake of ~1000 mg/d. However, this study indicate that Papillibacter is involved in body compositional changes....

Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans

Science.gov (United States)

Soare, Andreea; Cangemi, Roberto; Omodei, Daniela; Holloszy, John O.; Fontana, Luigi

2011-01-01

Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every minute by using ingested telemetric capsules in 24 men and women (mean age 53.7±9.4 yrs) consuming a CR diet for an average of 6 years, 24 age- and sex-matched sedentary (WD) and 24 body fat-matched exercise-trained (EX) volunteers, who were eating Western diets. The CR and EX groups were significantly leaner than the WD group. Energy intake was lower in the CR group (1769±348 kcal/d) than in the WD (2302±668 kcal/d) and EX (2798±760 kcal/d) groups (Ptemperatures were all significantly lower in the CR group than in the WD and EX groups (P≤0.01). Long-term CR with adequate nutrition in lean and weight-stable healthy humans is associated with a sustained reduction in core body temperature, similar to that found in CR rodents and monkeys. This adaptation is likely due to CR itself, rather than to leanness, and may be involved in slowing the rate of aging. PMID:21483032

Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats.

Science.gov (United States)

Milton-Laskibar, Iñaki; Aguirre, Leixuri; Fernández-Quintela, Alfredo; Rolo, Anabela P; Soeiro Teodoro, João; Palmeira, Carlos M; Portillo, María P

2017-07-11

The aims of the present study were to analyze the effect of resveratrol on liver steatosis in obese rats, to compare the effects induced by resveratrol and energy restriction and to research potential additive effects. Rats were initially fed a high-fat high-sucrose diet for six weeks and then allocated in four experimental groups fed a standard diet: a control group, a resveratrol-treated group, an energy restricted group and a group submitted to energy restriction and treated with resveratrol. We measured liver triacylglycerols, transaminases, FAS, MTP, CPT1a, CS, COX, SDH and ATP synthase activities, FATP2/FATP5, DGAT2, PPARα, SIRT1, UCP2 protein expressions, ACC and AMPK phosphorylation and PGC1α deacetylation. Resveratrol reduced triacylglycerols compared with the controls, although this reduction was lower than that induced by energy restriction. The mechanisms of action were different. Both decreased protein expression of fatty acid transporters, thus suggesting reduced fatty acid uptake from blood stream and liver triacylglycerol delivery, but only energy restriction reduced the assembly. These results show that resveratrol is useful for liver steatosis treatment within a balanced diet, although its effectiveness is lower than that of energy restriction. However, resveratrol is unable to increase the reduction in triacylglycerol content induced by energy restriction.

Dietary fat and not calcium supplementation or dairy product consumption is associated with changes in anthropometrics during a randomized, placebo-controlled energy-restriction trial

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Zemel Michael B

2011-10-01

Full Text Available Abstract Insufficient calcium intake has been proposed to cause unbalanced energy partitioning leading to obesity. However, weight loss interventions including dietary calcium or dairy product consumption have not reported changes in lipid metabolism measured by the plasma lipidome. Methods The objective of this study was to determine the relationships between dairy product or supplemental calcium intake with changes in the plasma lipidome and body composition during energy restriction. A secondary objective of this study was to explore the relationships among calculated macronutrient composition of the energy restricted diet to changes in the plasma lipidome, and body composition during energy restriction. Overweight adults (n = 61 were randomized into one of three intervention groups including a deficit of 500kcal/d: 1 placebo; 2 900 mg/d calcium supplement; and 3 3-4 servings of dairy products/d plus a placebo supplement. Plasma fatty acid methyl esters of cholesterol ester, diacylglycerol, free fatty acids, lysophosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine and triacylglycerol were quantified by capillary gas chromatography. Results After adjustments for energy and protein (g/d intake, there was no significant effect of treatment on changes in weight, waist circumference or body composition. Plasma lipidome did not differ among dietary treatment groups. Stepwise regression identified correlations between reported intake of monounsaturated fat (% of energy and changes in % lean mass (r = -0.44, P P Conclusions Dairy product consumption or calcium supplementation during energy restriction over the course of 12 weeks did not affect plasma lipids. Independent of calcium and dairy product consumption, short-term energy restriction altered body composition. Reported dietary fat composition of energy restricted diets was associated with the degree of change in body composition in these overweight and obese individuals.

Physical activity, energy restriction, and the risk of pancreatic cancer: Prospective study in the Netherlands

NARCIS (Netherlands)

Heinen, M.M.; Verhage, B.A.J.; Goldbohm, R.A.; Lumey, L.H.; Brandt, P.A. van den

2011-01-01

Background: Because of their influence on insulin concentrations, we hypothesized that both physical activity and energy restriction may reduce the risk of pancreatic cancer. Objective: We examined the associations between physical activity, proxies for energy restriction, and pancreatic cancer

Effects of obesity, energy restriction and neutering on the faecal microbiota of cats.

Science.gov (United States)

Fischer, Manuela M; Kessler, Alexandre M; Kieffer, Dorothy A; Knotts, Trina A; Kim, Kyoungmi; Wei, Alfreda; Ramsey, Jon J; Fascetti, Andrea J

2017-10-01

Surveys report that 25-57 % of cats are overweight or obese. The most evinced cause is neutering. Weight loss often fails; thus, new strategies are needed. Obesity has been associated with altered gut bacterial populations and increases in microbial dietary energy extraction, body weight and adiposity. This study aimed to determine whether alterations in intestinal bacteria were associated with obesity, energy restriction and neutering by characterising faecal microbiota using 16S rRNA gene sequencing in eight lean intact, eight lean neutered and eight obese neutered cats before and after 6 weeks of energy restriction. Lean neutered cats had a bacterial profile similar to obese rodents and humans, with a greater abundance (Pcats was due to a bloom in Peptostreptococcaceae. Obese cats had an 18 % reduction in fat mass after energy restriction (Pcats. Additional work is needed to understand how neutering, obesity and weight loss are related to changes in feline microbiota and how these microbial shifts affect host physiology.

Sleep restriction is not associated with a positive energy balance in adolescent boys

DEFF Research Database (Denmark)

Klingenberg, Lars; Chaput, Jean-Philippe; Holmbäck, Ulf

2012-01-01

A short sleep (SS) duration has been linked to obesity in observational studies. However, experimental evidence of the potential mechanisms of sleep restriction on energy balance is conflicting and, to our knowledge, nonexistent in adolescents.......A short sleep (SS) duration has been linked to obesity in observational studies. However, experimental evidence of the potential mechanisms of sleep restriction on energy balance is conflicting and, to our knowledge, nonexistent in adolescents....

Energy restriction during childhood and early adulthood and ovarian cancer risk

NARCIS (Netherlands)

Schouten, L.J.; Dijk, B.A.C. van; Lumey, L.; Goldbohm, R.A.; Brandt, P.A. van den

2011-01-01

Dietary energy restriction may protect against cancer. In parts of the Netherlands, mostly in larger cities, periods of chronically impaired nutrition and even severe famine (Hunger Winter 1944-1945) existed during the 1930s and World War II (1940-1945). We studied the association between energy

Impact of a moderately energy-restricted diet on energy metabolism and body composition in non-obese men

NARCIS (Netherlands)

Velthuis-te Wierik, E.J.M.; Westerterp, K.R.; Berg, H. van den

1995-01-01

Objective: Since little information is available on the capacity of the non-obese to adapt to a moderate decrease in energy intake, the effect of a 10-week moderately energy-restricted diet (ER) on energy expenditure and body composition was studied. Design: A controlled intervention study. After a

Fasting leptin and appetite responses induced by a 4-day 65%-energy-restricted diet.

Science.gov (United States)

Mars, M; de Graaf, C; de Groot, C P G M; van Rossum, C T M; Kok, F J

2006-01-01

Animal studies show that the leptin decline after acute severe caloric restriction is a peripheral signal to increase food intake. However, most human studies have failed to observe such a relationship. We studied the acute effects of severe caloric restriction on the association between serum leptin concentrations and subjective appetite. A total of 44 healthy adult men (aged: 43 +/- 5 years; BMI: 27.3 +/- 3.2 kg/m(2)). Fasting serum leptin concentrations and self-perceived appetite levels were measured during a 4-day diet containing 36% of the estimated energy requirements. Appetite levels were assessed with a 10-point Likert scale, reflecting hunger, fullness, desire to eat, prospective consumption and total appetite. After the 4-day energy deficit, fasting leptin concentrations decreased by 39.4% (95% CI: -43.6; -34.9%). This decline was associated with an increase in fasting hunger (r = -0.42; P < 0.01), desire to eat (r = -0.39; P < 0.05) and total appetite (r = -0.38; P < 0.05). Furthermore, the association between fasting leptin concentrations and fasting appetite levels became stronger during the energy restriction period (for total appetite: day 0 r = -0.15, P = 0.32; day 2 r = -0.31, P =< 0.05; day 4 r = -0.41, P < 0.01). The acute proportional reduction in fasting leptin after 4-day energy restriction is associated with an increase in self-perceived appetite. Additionally, the inverse association between proportional fasting leptin concentrations and self-perceived appetite response becomes stronger as energy restriction is prolonged. These findings suggest that leptin has an instrumental role in restoring energy balance in humans through the expression of appetite.

Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT)

NARCIS (Netherlands)

Boers, K.E.; Vijgen, S.M.C.; Bijlenga, D.; van der Post, J.A.M.; Bekedam, D.J.; Kwee, A.; van der Salm, P.C.M.; van Pampus, M.G.; Spaanderman, M.E.A.; Boer, K.; Duvekot, J.J.; Bremer, H.A.; Hasaart, T.H.M.; Delemarre, F.M.C.; Bloemenkamp, K.W.M.; van Meir, C.A.; Willekes, C.; Wijnen, E.J.; Rijken, M.; le Cessie, S.; Roumen, F.J.M.E.; Thornton, J.G.; van Lith, J.M.M.; Mol, B.W.J.; Scherjon, S.A.

2010-01-01

Objective To compare the effect of induction of labour with a policy of expectant monitoring for intrauterine growth restriction near term. Design Multicentre randomised equivalence trial (the Disproportionate Intrauterine Growth Intervention Trial At Term (DIGITAT)). Setting Eight academic and 44

Induction versus expectant monitoring for intrauterine growth restriction at term : randomised equivalence trial (DIGITAT)

NARCIS (Netherlands)

Boers, K. E.; Vijgen, S. M. C.; Bijlenga, D.; van der Post, J. A. M.; Bekedam, D. J.; Kwee, A.; van der Salm, P. C. M.; van Pampus, M. G.; Spaanderman, M. E. A.; de Boer, K.; Duvekot, J. J.; Bremer, H. A.; Hasaart, T. H. M.; Delemarre, F. M. C.; Bloemenkamp, K. W. M.; van Meir, C. A.; Willekes, C.; Wijnen, E. J.; Rijken, M.; le Cessie, S.; Roumen, F. J. M. E.; Thornton, J. G.; van Lith, J. M. M.; Mol, B. W. J.; Scherjon, S. A.

2010-01-01

Objective To compare the effect of induction of labour with a policy of expectant monitoring for intrauterine growth restriction near term. Design Multicentre randomised equivalence trial (the Disproportionate Intrauterine Growth Intervention Trial At Term (DIGITAT)). Setting Eight academic and 44

Effect of calorie restriction on energy expenditure in overweight and obese adult women.

Science.gov (United States)

Jiménez Jaime, Teresa; Leiva Balich, Laura; Barrera Acevedo, Gladys; de la Maza Cave, María Pía; Hirsch Birn, Sandra; Henríquez Parada, Sandra; Rodríguez Silva, Juan; Bunout Barnett, Daniel

2015-06-01

Energy expenditure (EE) may decrease in subjects on hypocaloric diets, in amounts that exceed body mass loss, favoring weight regain. To verify if a short-term caloric restriction lowers Resting Energy Expenditure (REE) and Total Energy Expenditure (TEE) more than predicted by changes in body composition, and if this reduction of EE is related with compliance to the diet. Twenty-two women aged 23-44 years with a body mass index (BMI) of 25-32 kg/m2, underwent a three-month calorie restriction treatment (20 kcal/kg initial weight) and were encouraged to increase their physical activity. At the beginning and end of the intervention, body composition (DEXA), REE, Physical Activity Energy Expenditure (PAEE) and TEE were assessed, through a combination of indirect calorimetry and actigraphy. Participants, who lost more or equal than 5% of their initial weight were considered compliant with the diet. In the compliant group, REE decreased, when expressed in absolute numbers or when adjusted by fat free mass (FFM) [-164 ± 168 kcal/day (10,6%) and -4,3 ± 4,6 kcal/kg FFM (10,5%)]. This decline was significantly greater than that observed in the non-compliant group [-6,2 ± 1.42 Kcal/day (0.16%) and -0,5 ± 3,4/Kg FFM (0.96%)]. FFM did not change in any of the two groups. At baseline, there was a significant correlation between FFM and REE (r = 0, 56 p women showed a significant reduction in both absolute and adjusted REE, which together with the loss of correlation between REE and FFM at the end of the intervention suggests a metabolic adaptation. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Leptin responsiveness to energy restriction: genetic variation in the leptin receptor gene

NARCIS (Netherlands)

Mars, M.; Rossum, van C.T.M.; Graaf, de C.; Hoebee, B.; Groot, de C.P.G.M.; Kok, F.J.

2004-01-01

Serum leptin concentrations are an important afferent signal in energy balance homeostasis. It has been speculated that the leptin responsiveness to energy restriction is affected by the functionality of the leptin receptor. The purpose of this analysis was to explore the effect of polymorphisms in

Nutrigenetics and nutrigenomics of caloric restriction.

Science.gov (United States)

Abete, Itziar; Navas-Carretero, Santiago; Marti, Amelia; Martinez, J Alfredo

2012-01-01

Obesity is a complex disease resulting from a chronic and long-term positive energy balance in which both genetic and environmental factors are involved. Weight-reduction methods are mainly focused on dietary changes and increased physical activity. However, responses to nutritional intervention programs show a wide range of interindividual variation, which is importantly influenced by genetic determinants. In this sense, subjects carrying several obesity-related single-nucleotide polymorphisms (SNPs) show differences in the response to calorie-restriction programs. Furthermore, there is evidence indicating that dietary components not only fuel the body but also participate in the modulation of gene expression. Thus, the expression pattern and nutritional regulation of several obesity-related genes have been studied, as well as those that are differentially expressed by caloric restriction. The responses to caloric restriction linked to the presence of SNPs in obesity-related genes are reviewed in this chapter. Also, the influence of energy restriction on gene expression pattern in different tissues is addressed. Copyright © 2012 Elsevier Inc. All rights reserved.

Effect of Intermittent Energy Restriction on Flow Mediated Dilatation, a Measure of Endothelial Function: A Short Report.

Science.gov (United States)

Headland, Michelle L; Clifton, Peter M; Keogh, Jennifer B

2018-06-04

Intermittent energy restriction is a popular alternative to daily energy restriction for weight loss; however, it is unknown if endothelial function, a risk factor for cardiovascular disease, is altered by periods of severe energy restriction. The objective of the study was to determine the impact of two consecutive very low energy intake days, which is the core component of the 5:2 intermittent energy restriction diet strategy, on endothelial function compared to consecutive ad libitum eating days. The secondary objective was to explore the effects of these dietary conditions on fasting glucose concentrations. This was a 4-week randomized, single-blinded, crossover study of 35 participants. Participants consumed a very low energy diet (500 calories for women, 600 calories for men) on two consecutive days per week and 5 days of habitual eating. In weeks 3 and 4 of the trial, participants had measurements of flow mediated dilatation (FMD) and blood samples taken following either 2 habitual eating days or 2 energy restricted days in a randomized order. FMD values were not different after the two eating states (8.6% vs. 8.3%, p = 0.7). All other outcome variables were unchanged. Endothelial function, as measured by flow mediated dilatation, was not altered by two consecutive very low energy intake days. Further investigations assessing the impact in specific population groups as well as different testing conditions would be beneficial.

Calculation of the Local Free Energy Landscape in the Restricted Region by the Modified Tomographic Method.

Science.gov (United States)

Chen, Changjun

2016-03-31

The free energy landscape is the most important information in the study of the reaction mechanisms of the molecules. However, it is difficult to calculate. In a large collective variable space, a molecule must take a long time to obtain the sufficient sampling during the simulation. To save the calculation quantity, decreasing the sampling region and constructing the local free energy landscape is required in practice. However, the restricted region in the collective variable space may have an irregular shape. Simply restricting one or more collective variables of the molecule cannot satisfy the requirement. In this paper, we propose a modified tomographic method to perform the simulation. First, it divides the restricted region by some hyperplanes and connects the centers of hyperplanes together by a curve. Second, it forces the molecule to sample on the curve and the hyperplanes in the simulation and calculates the free energy data on them. Finally, all the free energy data are combined together to form the local free energy landscape. Without consideration of the area outside the restricted region, this free energy calculation can be more efficient. By this method, one can further optimize the path quickly in the collective variable space.

Estimation of fluctuation in restricted energy loss

International Nuclear Information System (INIS)

Doke, T.; Hayashi, T.; Nagata, K.

1983-01-01

Restricted Energy Loss (REL) is defined as an energy loss [(dE/dX)/sub E//sub delta/<ν/] that produced the delta-rays of energies less than some specified energy ν and is often used as a simple measure of track structure. For example, REL is a measure of track formation threshold in plastic track detector and the growth rate of track in chemical etching solution is considered to depend only on REL given along the track. Using a stack of elastic sheets, recently, it became possible to identify isotopes of incident particles. In that case, the limit of mass resolution is determined by fluctuation of REL in the length of etch pit produced along the path of particle. A computer program was developed to calculate the probability distribution for energy deposition in absorber allowing for electron escape. In this calculation, it is assumed that all electrons with energies greater than a certain value epsilon/sub d/ escape. This means that this calculation directly gives the fluctuation of REL. Therefore, we tried to use the computer program to estimate the ultimate mass resolution in plastic detector. In this paper, we show firstly the comparison of ASB's calculation with the experimental results obtained by a gas counter and next the results of estimation of ultimate mass resolution in plastic detectors

Could Intermittent Energy Restriction and Intermittent Fasting Reduce Rates of Cancer in Obese, Overweight, and Normal-Weight Subjects? A Summary of Evidence12

Science.gov (United States)

2016-01-01

Animal studies and human observational data link energy restriction (ER) to reduced rates of carcinogenesis. Most of these studies have involved continuous energy restriction (CER), but there is increasing public and scientific interest in the potential health and anticancer effects of intermittent energy restriction (IER) or intermittent fasting (IF), which comprise periods of marked ER or total fasting interspersed with periods of normal eating. This review summarizes animal studies that assessed tumor rates with IER and IF compared with CER or ad libitum feed consumption. The relevance of these animal data to human cancer is also considered by summarizing available human studies of the effects of IER or IF compared with CER on cancer biomarkers in obese, overweight, and normal-weight subjects. IER regimens that include periods of ER alternating with ad libitum feed consumption for 1, 2, or 3 wk have been reported to be superior to CER in reducing tumor rates in most spontaneous mice tumor models. Limited human data from short-term studies (≤6 mo) in overweight and obese subjects have shown that IER can lead to greater improvements in insulin sensitivity (homeostasis model assessment) than can CER, with comparable reductions in adipokines and inflammatory markers and minor changes in the insulin-like growth factor axis. There are currently no data comparing IER or IF with CER in normal-weight subjects. The benefits of IER in these short-term trials are of interest, but not sufficient evidence to recommend the use of IER above CER. Longer-term human studies of adherence to and efficacy and safety of IER are required in obese and overweight subjects, as well as normal-weight subjects. PMID:27422504

Could Intermittent Energy Restriction and Intermittent Fasting Reduce Rates of Cancer in Obese, Overweight, and Normal-Weight Subjects? A Summary of Evidence.

Science.gov (United States)

Harvie, Michelle N; Howell, Tony

2016-07-01

Animal studies and human observational data link energy restriction (ER) to reduced rates of carcinogenesis. Most of these studies have involved continuous energy restriction (CER), but there is increasing public and scientific interest in the potential health and anticancer effects of intermittent energy restriction (IER) or intermittent fasting (IF), which comprise periods of marked ER or total fasting interspersed with periods of normal eating. This review summarizes animal studies that assessed tumor rates with IER and IF compared with CER or ad libitum feed consumption. The relevance of these animal data to human cancer is also considered by summarizing available human studies of the effects of IER or IF compared with CER on cancer biomarkers in obese, overweight, and normal-weight subjects. IER regimens that include periods of ER alternating with ad libitum feed consumption for 1, 2, or 3 wk have been reported to be superior to CER in reducing tumor rates in most spontaneous mice tumor models. Limited human data from short-term studies (≤6 mo) in overweight and obese subjects have shown that IER can lead to greater improvements in insulin sensitivity (homeostasis model assessment) than can CER, with comparable reductions in adipokines and inflammatory markers and minor changes in the insulin-like growth factor axis. There are currently no data comparing IER or IF with CER in normal-weight subjects. The benefits of IER in these short-term trials are of interest, but not sufficient evidence to recommend the use of IER above CER. Longer-term human studies of adherence to and efficacy and safety of IER are required in obese and overweight subjects, as well as normal-weight subjects. © 2016 American Society for Nutrition.

Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets.

Science.gov (United States)

Seyfried, Thomas N; Kiebish, Michael; Mukherjee, Purna; Marsh, Jeremy

2008-11-01

Information is presented on the calorically restricted ketogenic diet (CRKD) as an alternative therapy for brain cancer. In contrast to normal neurons and glia, which evolved to metabolize ketone bodies as an alternative fuel to glucose under energy-restricted conditions, brain tumor cells are largely glycolytic due to mitochondrial defects and have a reduced ability to metabolize ketone bodies. The CRKD is effective in managing brain tumor growth in animal models and in patients, and appears to act through antiangiogenic, anti-inflammatory, and proapoptotic mechanisms.

Short-term memory deficits correlate with hippocampal-thalamic functional connectivity alterations following acute sleep restriction.

Science.gov (United States)

Chengyang, Li; Daqing, Huang; Jianlin, Qi; Haisheng, Chang; Qingqing, Meng; Jin, Wang; Jiajia, Liu; Enmao, Ye; Yongcong, Shao; Xi, Zhang

2017-08-01

Acute sleep restriction heavily influences cognitive function, affecting executive processes such as attention, response inhibition, and memory. Previous neuroimaging studies have suggested a link between hippocampal activity and short-term memory function. However, the specific contribution of the hippocampus to the decline of short-term memory following sleep restriction has yet to be established. In the current study, we utilized resting-state functional magnetic resonance imaging (fMRI) to examine the association between hippocampal functional connectivity (FC) and the decline of short-term memory following total sleep deprivation (TSD). Twenty healthy adult males aged 20.9 ± 2.3 years (age range, 18-24 years) were enrolled in a within-subject crossover study. Short-term memory and FC were assessed using a Delay-matching short-term memory test and a resting-state fMRI scan before and after TSD. Seed-based correlation analysis was performed using fMRI data for the left and right hippocampus to identify differences in hippocampal FC following TSD. Subjects demonstrated reduced alertness and a decline in short-term memory performance following TSD. Moreover, fMRI analysis identified reduced hippocampal FC with the superior frontal gyrus (SFG), temporal regions, and supplementary motor area. In addition, an increase in FC between the hippocampus and bilateral thalamus was observed, the extent of which correlated with short-term memory performance following TSD. Our findings indicate that the disruption of hippocampal-cortical connectivity is linked to the decline in short-term memory observed after acute sleep restriction. Such results provide further evidence that support the cognitive impairment model of sleep deprivation.

Energy budget, behavior and leptin in striped hamsters subjected to food restriction and refeeding.

Directory of Open Access Journals (Sweden)

Zhi-Jun Zhao

Full Text Available Food restriction induces a loss of body mass that is often followed by rapid regaining of the lost weight when the restriction ends, consequently increasing a risk of development of obesity. To determine the physiological and behavioral mechanisms underlining the regaining, striped hamsters were restricted to 85% of initial food intake for 4 weeks and refed ad libitum for another 4 weeks. Changes in body mass, energy budget, activity, body composition and serum leptin level were measured. Body mass, body fat mass and serum leptin level significantly decreased in food-restricted hamsters, and increased when the restriction ended, showing a short "compensatory growth" rather than over-weight or obesity compared with ad libitum controls. During restriction, the time spent on activity increased significantly, which was opposite to the changes in serum leptin level. Food intake increased shortly during refeeding, which perhaps contributed to the rapid regaining of body mass. No correlation was observed between serum leptin and energy intake, while negative correlations were found in hamsters that were refed for 7 and 28 days. Exogenous leptin significantly decreased the time spent on activity during food restriction and attenuated the increase in food intake during refeeding. This suggests that low leptin in restricted animals may function as a starvation signal to induce an increase in activity behavior, and high leptin likely serves as a satiety signal to prevent activity during refeeding. Leptin may play a crucial role in controlling food intake when the restriction ends, and consequently preventing overweight.

Effect of Intermittent Energy Restriction on Flow Mediated Dilatation, a Measure of Endothelial Function: A Short Report

Directory of Open Access Journals (Sweden)

Michelle L. Headland

2018-06-01

Full Text Available Intermittent energy restriction is a popular alternative to daily energy restriction for weight loss; however, it is unknown if endothelial function, a risk factor for cardiovascular disease, is altered by periods of severe energy restriction. The objective of the study was to determine the impact of two consecutive very low energy intake days, which is the core component of the 5:2 intermittent energy restriction diet strategy, on endothelial function compared to consecutive ad libitum eating days. The secondary objective was to explore the effects of these dietary conditions on fasting glucose concentrations. This was a 4-week randomized, single-blinded, crossover study of 35 participants. Participants consumed a very low energy diet (500 calories for women, 600 calories for men on two consecutive days per week and 5 days of habitual eating. In weeks 3 and 4 of the trial, participants had measurements of flow mediated dilatation (FMD and blood samples taken following either 2 habitual eating days or 2 energy restricted days in a randomized order. FMD values were not different after the two eating states (8.6% vs. 8.3%, p = 0.7. All other outcome variables were unchanged. Endothelial function, as measured by flow mediated dilatation, was not altered by two consecutive very low energy intake days. Further investigations assessing the impact in specific population groups as well as different testing conditions would be beneficial.

Growth, meat and feed efficiency traits of lambs born to ewes submitted to energy restriction during mid-gestation.

Science.gov (United States)

Piaggio, L; Quintans, G; San Julián, R; Ferreira, G; Ithurralde, J; Fierro, S; Pereira, A S C; Baldi, F; Banchero, G E

2018-02-01

The objective of this study was to evaluate the effects of the energy restriction of gestation of adult ewes from day 45 to day 115 on lamb live performance parameters, carcass and meat traits. In experiment I, dietary energy was restricted at 70% of the metabolizable energy (ME) requirements, after which ewes were re-fed ad libitum until lambing. In experiment II, dietary energy was restricted at 60% of the ME requirements, and ewes were re-fed to ME requirements until lambing. All ewes grazed together from the end of the restriction periods to weaning. Lambs were weaned and lot fed until slaughter. Feed intake, weight gain and feed efficiency were recorded, and body fat thickness and ribeye area (REA) were measured in the longissimus thoracis muscle. After slaughter, carcass weight and yield, fat depth, carcass and leg length, and frenched rack and leg weights and yields were determined. Muscle fiber type composition, Warner-Bratzler shear force, pH and color were determined in the longissimus lumborum muscle. In experiment I, energy restriction followed by ad libitum feeding affected lamb birth weight (P0.05) were observed on later BW, REA, BF or carcass traits. Lambs born to non-restricted-fed ewes had higher (Penergy restriction followed by ME requirements feeding, affected (Pefficient (P=0.16) than lambs from unrestricted dams. Ribeye area and BF were not influenced by treatment. Treatment significantly affected slaughter weight, but had no effects on carcass yield and traits or on meat traits. The results obtained in both experiments indicate submitting ewes to energy restriction during gestation affects the performance of their progeny but the final outcome would depend on the ewe's re-feeding level during late gestation and the capacity of the offspring to compensate the in utero restriction after birth.

Cardioprotective Signature of Short-Term Caloric Restriction.

Directory of Open Access Journals (Sweden)

Hossein Noyan

Full Text Available To understand the molecular pathways underlying the cardiac preconditioning effect of short-term caloric restriction (CR.Lifelong CR has been suggested to reduce the incidence of cardiovascular disease through a variety of mechanisms. However, prolonged adherence to a CR life-style is difficult. Here we reveal the pathways that are modulated by short-term CR, which are associated with protection of the mouse heart from ischemia.Male 10-12 wk old C57bl/6 mice were randomly assigned to an ad libitum (AL diet with free access to regular chow, or CR, receiving 30% less food for 7 days (d, prior to myocardial infarction (MI via permanent coronary ligation. At d8, the left ventricles (LV of AL and CR mice were collected for Western blot, mRNA and microRNA (miR analyses to identify cardioprotective gene expression signatures. In separate groups, infarct size, cardiac hemodynamics and protein abundance of caspase 3 was measured at d2 post-MI.This short-term model of CR was associated with cardio-protection, as evidenced by decreased infarct size (18.5±2.4% vs. 26.6±1.7%, N=10/group; P=0.01. mRNA and miR profiles pre-MI (N=5/group identified genes modulated by short-term CR to be associated with circadian clock, oxidative stress, immune function, apoptosis, metabolism, angiogenesis, cytoskeleton and extracellular matrix (ECM. Western blots pre-MI revealed CR-associated increases in phosphorylated Akt and GSK3ß, reduced levels of phosphorylated AMPK and mitochondrial related proteins PGC-1α, cytochrome C and cyclooxygenase (COX IV, with no differences in the levels of phosphorylated eNOS or MAPK (ERK1/2; p38. CR regimen was also associated with reduced protein abundance of cleaved caspase 3 in the infarcted heart and improved cardiac function.

Long Term Follow-up of Ventilated Patients with Thoracic Restriction and Neuromuscular Disease

Directory of Open Access Journals (Sweden)

Dina Brooks

2002-01-01

Full Text Available OBJECTIVE: To evaluate the long term effects of home mechanical ventilation (HMV on pulmonary function, nighttime gas exchange, daytime arterial blood gases, sleep architecture and functional exercise capacity (6 min walk. Patients with respiratory failure attributable to thoracic restrictive disease (TRD (kyphoscoliosis or neuromuscular disease (NMD were assessed, ventilated, trained and followed in a dedicated unit for the care of patients requiring long term ventilation.

Nuclear energy terms

Energy Technology Data Exchange (ETDEWEB)

1976-01-01

This is an English-Afrikaans / Afrikaans-English dictionary compiled by the Technical Language Committee of the Atomic Energy Board in collaboration with the Vaktaalburo of the Suid-Afrikaanse Akademie vir Wetenskap en Kuns containing 8515 terms on nuclear energy.

Nuclear energy terms

International Nuclear Information System (INIS)

1976-01-01

This is an English-Afrikaans / Afrikaans-English dictionary compiled by the Technical Language Committee of the Atomic Energy Board in collaboration with the Vaktaalburo of the Suid-Afrikaanse Akademie vir Wetenskap en Kuns containing 8515 terms on nuclear energy

Integrating spot short-term measurements of carbon emissions and backward dietary energy partition calculations to estimate intake in lactating dairy cows fed ad libitum or restricted.

Science.gov (United States)

Pereira, A B D; Utsumi, S A; Dorich, C D; Brito, A F

2015-12-01

The objective of this study was to use spot short-term measurements of CH4 (QCH4) and CO2 (QCO2) integrated with backward dietary energy partition calculations to estimate dry matter intake (DMI) in lactating dairy cows. Twelve multiparous cows averaging 173±37d in milk and 4 primiparous cows averaging 179±27d in milk were blocked by days in milk, parity, and DMI (as a percentage of body weight) and, within each block, randomly assigned to 1 of 2 treatments: ad libitum intake (AL) or restricted intake (RI=90% DMI) according to a crossover design. Each experimental period lasted 22d with 14d for treatments adaptation and 8d for data and sample collection. Diets contained (dry matter basis): 40% corn silage, 12% grass-legume haylage, and 48% concentrate. Spot short-term gas measurements were taken in 5-min sampling periods from 15 cows (1 cow refused sampling) using a portable, automated, open-circuit gas quantification system (GreenFeed, C-Lock Inc., Rapid City, SD) with intervals of 12h between the 2daily samples. Sampling points were advanced 2h from a day to the next to yield 16 gas samples per cow over 8d to account for diurnal variation in QCH4 and QCO2. The following equations were used sequentially to estimate DMI: (1) heat production (MJ/d)=(4.96 + 16.07 ÷ respiratory quotient) × QCO2; respiratory quotient=0.95; (2) metabolizable energy intake (MJ/d)=(heat production + milk energy) ± tissue energy balance; (3) digestible energy (DE) intake (MJ/d)=metabolizable energy + CH4 energy + urinary energy; (4) gross energy (GE) intake (MJ/d)=DE + [(DE ÷ in vitro true dry matter digestibility) - DE]; and (5) DMI (kg/d)=GE intake estimated ÷ diet GE concentration. Data were analyzed using the MIXED procedure of SAS (SAS Institute Inc., Cary, NC) and Fit Model procedure in JMP (α=0.05; SAS Institute Inc.). Cows significantly differed in DMI measured (23.8 vs. 22.4kg/d for AL and RI, respectively). Dry matter intake estimated using QCH4 and QCO2 coupled with

Validation of the effects of small differences in dietary metabolizable energy and feed restriction in first-cycle laying hens.

Science.gov (United States)

Murugesan, G R; Persia, M E

2013-05-01

An experiment was conducted to evaluate energy utilization of laying hens fed diets containing 2 ME concentrations, using response criteria including performance, BW, abdominal fat pad, and energy digestibility. The experiment was a 2 × 2 factorial with 2 feeding regimens (ad libitum and restriction fed), and 2 dietary ME levels [2,880 kcal/kg of ME (CON); and 2,790 kcal/kg of ME (LME)]. A total of 60 Hy-Line W36 first-cycle laying hens were fed experimental diets, resulting in 15 individually caged hens for each of the 4 treatments. Hens in the restriction-fed group were fed 90 g of feed per day. The CON diet was formulated to meet or exceed the NRC (1994) recommendations with 2,880 kcal/kg, whereas the LME diet was similar with the exception of a 90 kcal/kg reduction in ME. Hens were fed experimental diets for 12 wk from hen 28 to 39 wk of age. Hen day egg production, weekly feed intake, and every 2 wk, egg weights and egg mass were recorded, whereas hen BW was measured every 4 wk. Excreta samples were collected over the last 5 d of experiment to determine AMEn. Abdominal fat pads were measured individually for all hens at the end of experiment. There were no interactions between feeding regimens and dietary ME levels throughout the experiment. Feed restriction resulted in reductions (P ≤ 0.01) in hen day egg production, BW, and abdominal fat pad, indicating reduced nutrient availability to partition toward production, maintenance, and storage functions. The reduction in energy intake between CON and LME fed birds (90 kcal/kg) did not change the energy partitioned toward production or maintenance, but reduced (P = 0.03) the energy stored (reduced fat pad) of LME-fed hens. These results suggest that energy is used following the pattern of production and maintenance before storage requirements and that fat pad (energy storage) may be the most sensitive indicator of dietary energy status over short-term in Hy-Line W36 laying hens.

Decreases in fasting leptin and insulin concentrations after acute energy restriction and subsequent compensation in food intake.

Science.gov (United States)

Mars, Monica; de Graaf, Cees; de Groot, Lisette C P G M; Kok, Frans J

2005-03-01

The decrease in leptin after energy restriction is a starvation signal to the brain. Several studies have found an association between this decrease and subjective appetite; however, no solid data are available on the acute decrease in fasting leptin concentration and subsequent caloric compensation. The objective was to assess the effect of acute decreases in fasting leptin concentrations, induced by energy restriction, on subsequent energy intake compensation. We hypothesized that men with a large decrease in fasting leptin concentrations would have larger ad libitum energy intakes than would men with a small decrease in leptin. Thirty-four male unrestrained eaters [age: 23 +/- 3 y; body mass index (in kg/m(2)): 22.3 +/- 1.6] participated in a semicontrolled intervention study. Fasting serum leptin and insulin concentrations were measured before and 2 d after 62% energy restriction. Energy intake was measured on the 2 following days on which food was provided ad libitum. During energy restriction, fasting leptin and insulin concentrations decreased by 27.2% (95% CI: -34.4%, -19.9%) and 30.7% (95% CI: -41.0%, -20.4%), respectively. Subjects consumed 143 +/- 27% of their estimated energy requirements (18.3 +/- 2.9 MJ) on the first day and 124 +/- 20% (16.0 +/- 2.6 MJ) on the second day of ad libitum intake. No significant correlations were observed between decreases in fasting leptin or insulin concentrations and subsequent ad libitum energy intake; however, decreases in insulin were correlated with an increase in carbohydrate intake (r=-0.49, P < 0.01). Although fasting leptin concentrations decreased significantly during energy restriction and subjects showed compensatory behavior during subsequent ad libitum food intake, no association was observed between the decrease in fasting leptin concentrations and caloric compensation.

Energy restriction during childhood and early adulthood and ovarian cancer risk.

Directory of Open Access Journals (Sweden)

Leo J Schouten

Full Text Available Dietary energy restriction may protect against cancer. In parts of The Netherlands, mostly in larger cities, periods of chronically impaired nutrition and even severe famine (Hunger Winter 1944-1945 existed during the 1930s and World War II (1940-1945. We studied the association between energy restriction during childhood and early adulthood on the risk of ovarian cancer later in life. In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women aged 55-69 years at baseline. Follow-up for cancer was established by record linkage to the Netherlands Cancer Registry. After 16.3 years of follow-up, 364 invasive epithelial ovarian cancer cases and 2220 subcohort members (sampled from the total cohort directly after baseline with complete information confounders were available for case-cohort analyses. In multivariable analysis, ovarian cancer risk was lower for participants with an unemployed father during the 1930s (Hazard Ratio (HR, 0.70; 95% Confidence Interval (CI, 0.47-1.06 compared to participants with an employed father as well as for participants living in a city during World War II (HR, 0.69; 95% CI, 0.54-0.90 compared to participants living in the country-side. Residence in a Western City during the famine (Hunger Winter was not associated with a decreased risk. Our results show a relation between proxy variables for modest energy restriction over a longer period of time during childhood or early adulthood and a reduced ovarian cancer risk.

Childhood and adolescent energy restriction and subsequent colorectal cancer risk: results from the Netherlands Cohort Study.

Science.gov (United States)

Hughes, Laura A E; van den Brandt, Piet A; Goldbohm, R Alexandra; de Goeij, Anton F P M; de Bruïne, Adriaan P; van Engeland, Manon; Weijenberg, Matty P

2010-10-01

Energy restriction during childhood and adolescence is suggested to lower colorectal cancer (CRC) risk. We investigated this in the Netherlands Cohort Study. Information on diet and other risk factors was collected by a baseline questionnaire in 1986 when cohort members were 55-69 years of age (n = 120 852). Three indicators of early life exposure to energy restriction were assessed: father's employment status during the Economic Depression (1932-40), place of residence during Second World War years (1940-44) and the 'Hunger Winter' (1944-45), a severe famine. Using the case-cohort approach, incidence rate ratios (RRs) and 95% confidence intervals (CIs) were calculated for total colorectal, proximal colon, distal colon, rectosigmoid and rectal cancers, according to the three time periods of energy restriction. After 16.3 years of follow-up, 2573 cases were available for multivariate analyses. Men who lived in a western city during the Hunger Winter and therefore exposed to the highest degree of energy restriction, had a lower risk of developing CRC (RR: 0.81, 95% CI: 0.68-0.98), and tumours of the proximal colon (RR: 0.72, 95% CI: 0.54-0.96) and rectum (RR: 0.71, 95% CI: 0.53-0.96). In women, non-statistically significant inverse associations were observed for tumours of the distal colon, rectosigmoid and rectum. Inverse associations were also observed between the other two exposure times and studied endpoints, though not statistically significant. This unique observational evidence suggests that severe energy restriction during childhood and adolescence may lower CRC risk, especially in men, thus providing insight regarding the role of energy intake during early life in CRC development.

Level of energy restriction alters body condition score and morphometric profile in obese Shetland ponies.

Science.gov (United States)

Bruynsteen, L; Moons, C P H; Janssens, G P J; Harris, P A; Vandevelde, K; Lefère, L; Duchateau, L; Hesta, M

2015-10-01

Due to the high prevalence of obesity in some horses and ponies (especially in the leisure horse sector), effective and safe weight loss strategies are required. The present study evaluated the effect of two different energy restriction rates on physical, morphometric and welfare parameters in 18 obese (body condition score [BCS] 7-9/9) Shetland geldings. The trial was divided into three periods: (1) a 4 week adaptation period, during which the maintenance energy intakes to maintain a stable obese bodyweight were determined (100% MERob); (2) a 16.5-week weight loss period during which the ponies were randomly divided into three groups (n = 6/group) comprising a control group (CONTROL), moderate energy restricted (MOD), and severe energy restricted (SEV) groups that were respectively fed at 100%, 80% and 60% of their individual MERob; and (3) a 3 week follow up period in which the ponies were again fed at their outset individual 100% MERob. Between the start and end of the weight loss period, significant pairwise differences between the three treatment groups were seen for bodyweight, BCS, heart girth, belly girth, and relative ultrasound fat depth at the level of loin and ribs at several time points (P < 0.05). The higher energy restriction was associated with a faster decrease in BCS, tail head, and heart plus belly girth, but no gastric ulcers or stereotypic behaviours were seen. Copyright © 2015 Elsevier Ltd. All rights reserved.

TFAP2B influences the effect of dietary fat on weight loss under energy restriction

DEFF Research Database (Denmark)

Stocks, Tanja; Angquist, Lars; Banasik, Karina

2012-01-01

Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction.......Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction....

Effects of Long-Term Protein Restriction on Meat Quality, Muscle Amino Acids, and Amino Acid Transporters in Pigs.

Science.gov (United States)

Yin, Jie; Li, Yuying; Zhu, Xiaotong; Han, Hui; Ren, Wenkai; Chen, Shuai; Bin, Peng; Liu, Gang; Huang, Xingguo; Fang, Rejun; Wang, Bin; Wang, Kai; Sun, Liping; Li, Tiejun; Yin, Yulong

2017-10-25

This study aimed to investigate the long-term effects of protein restriction from piglets to finishing pigs for 16 weeks on meat quality, muscle amino acids, and amino acid transporters. Thirty-nine piglets were randomly divided into three groups: a control (20-18-16% crude protein, CP) and two protein restricted groups (17-15-13% CP and 14-12-10% CP). The results showed that severe protein restriction (14-12-10% CP) inhibited feed intake and body weight, while moderate protein restriction (17-15-13% CP) had little effect on growth performance in pigs. Meat quality (i.e., pH, color traits, marbling, water-holding capacity, and shearing force) were tested, and the results exhibited that 14-12-10% CP treatment markedly improved muscle marbling score and increased yellowness (b*). pH value (45 min) was significantly higher in 17-15-13% CP group than that in other groups. In addition, protein restriction reduced muscle histone, arginine, valine, and isoleucine abundances and enhanced glycine and lysine concentrations compared with the control group, while the RT-PCR results showed that protein restriction downregulated amino acids transporters. Mechanistic target of rapamycin (mTOR) signaling pathway was inactivated in the moderate protein restricted group (17-15-13% CP), while severe protein restriction with dietary 14-12-10% CP markedly enhanced mTOR phosphorylation. In conclusion, long-term protein restriction affected meat quality and muscle amino acid metabolism in pigs, which might be associated with mTOR signaling pathway.

Asthma in children in relation to pre-term birth and fetal growth restriction

NARCIS (Netherlands)

Koshy, Gibby; Akrouf, Kafya A. S.; Kelly, Yvonne; Delpisheh, Ali; Brabin, Bernard J.

2013-01-01

To assess the impact of parental asthma on risk of pre-term birth (PTB) and intrauterine growth restriction, and their subsequent association with childhood asthma. Three sequential cross-sectional surveys were conducted in 1993 (3,746), 1998 (1,964) and 2006 (1,074) in the same 15 schools among

Role of uteroplacental and fetal Doppler in identifying fetal growth restriction at term.

OpenAIRE

Khalil, A; Thilaganathan, B

2017-01-01

Identification of the fetus at risk of adverse outcome at term is a challenge to both clinicians and researchers alike. Despite the fact that fetal growth restriction (FGR) is a known risk factor for stillbirth, at least two thirds of the stillbirth cases at term are not small for gestational age (SGA) - a commonly used proxy for FGR. However, the majority of SGA fetuses are constitutionally small babies and do not suffer from adverse perinatal outcome. The cerebroplacental ratio (CPR) is eme...

Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model.

Science.gov (United States)

Diane, Abdoulaye; Kupreeva, Maria; Borthwick, Faye; Proctor, Spencer D; Pierce, W David; Vine, Donna F

2015-09-01

Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders in women of reproductive age characterized by ovulatory dysfunction, hyperandrogenism and cardiometabolic risk. The overweight-obese PCOS phenotype appears to have exacerbated reproductive dysfunction and cardiometabolic risk. In overweight-obese adult women with PCOS, exercise and energy restricted diets have shown limited and inconsistent effects on both cardiometabolic indices and reproductive outcomes. We hypothesized that an early lifestyle intervention involving exercise and dietary energy restriction to prevent or reduce the propensity for adiposity would modulate reproductive indices and cardiometabolic risk in an obese PCOS-prone rodent model. Weanling obese PCOS-prone and Lean-Control JCR:LA-cp rodents were given a chow diet ad libitum or an energy-restricted diet combined with or without voluntary exercise (4  h/day) for 8 weeks. Dietary energy restriction and exercise lowered total body weight gain and body fat mass by 30% compared to free-fed sedentary or exercising obese PCOS-prone animals (Pexercise intensity compared to free-feeding plus exercise conditions. Energy restriction and exercise decreased fasting plasma triglycerides and apoB48 concentrations in obese PCOS-prone animals compared to free-fed and exercise or sedentary groups. The energy restriction and exercise combination in obese PCOS-prone animals significantly increased plasma sex-hormone binding globulin, hypothalamic cocaine-and amphetamine-regulated transcript (CART) and Kisspeptin mRNA expression to levels of the Lean-Control group, and this was further associated with improvements in estrous cyclicity. The combination of exercise and dietary energy restriction when initiated in early life exerts beneficial effects on cardiometabolic and reproductive indices in an obese PCOS-prone rodent model, and this may be associated with normalization of the hypothalamic neuropeptides, Kisspeptin and CART

Long-Term Monitoring of Utility-Scale Solar Energy Development and Application of Remote Sensing Technologies: Summary Report

Energy Technology Data Exchange (ETDEWEB)

Hamada, Yuki [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division; Grippo, Mark A. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division; Smith, Karen P. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division

2014-09-30

In anticipation of increased utility-scale solar energy development over the next 20 to 50 years, federal agencies and other organizations have identified a need to develop comprehensive long-term monitoring programs specific to solar energy development. Increasingly, stakeholders are requesting that federal agencies, such as the U.S. Department of the Interior Bureau of Land Management (BLM), develop rigorous and comprehensive long-term monitoring programs. Argonne National Laboratory (Argonne) is assisting the BLM in developing an effective long-term monitoring plan as required by the BLM Solar Energy Program to study the environmental effects of solar energy development. The monitoring data can be used to protect land resources from harmful development practices while at the same time reducing restrictions on utility-scale solar energy development that are determined to be unnecessary. The development of a long-term monitoring plan that incorporates regional datasets, prioritizes requirements in the context of landscape-scale conditions and trends, and integrates cost-effective data collection methods (such as remote sensing technologies) will translate into lower monitoring costs and increased certainty for solar developers regarding requirements for developing projects on public lands. This outcome will support U.S. Department of Energy (DOE) Sunshot Program goals. For this reason, the DOE provided funding for the work presented in this report.

Verbal short-term memory span in children: long-term modality dependent effects of intrauterine growth restriction.

Science.gov (United States)

Geva, R; Eshel, R; Leitner, Y; Fattal-Valevski, A; Harel, S

2008-12-01

Recent reports showed that children born with intrauterine growth restriction (IUGR) are at greater risk of experiencing verbal short-term memory span (STM) deficits that may impede their learning capacities at school. It is still unknown whether these deficits are modality dependent. This long-term, prospective design study examined modality-dependent verbal STM functions in children who were diagnosed at birth with IUGR (n = 138) and a control group (n = 64). Their STM skills were evaluated individually at 9 years of age with four conditions of the Visual-Aural Digit Span Test (VADS; Koppitz, 1981): auditory-oral, auditory-written, visuospatial-oral and visuospatial-written. Cognitive competence was evaluated with the short form of the Wechsler Intelligence Scales for Children--revised (WISC-R95; Wechsler, 1998). We found IUGR-related specific auditory-oral STM deficits (p long-term relationship between prenatal aberrant head growth and auditory verbal STM deficits by the end of the first decade of life. Empirical, clinical and educational implications are presented.

Inactivity-induced bone loss is not exacerbated by moderate energy restriction

Science.gov (United States)

Heer, M.; Boese, A.; Baecker, N.; Zittermann, A.; Smith, S. M.

Severe energy restriction leads to decreased bone mineral density (BMD) in postmenopausal women, adolescent females, and in male athletes. Astronauts in space also lose bone mass, and most of them have reduced energy intake (about 25 % below requirements). The aim of our study was to examine if bone loss in space is partly induced by moderate energy restriction. Physiological changes of space flight were simulated by 6 head-down tilt bed rest (HDBR). Nine healthy male subjects (age: 23.6 ± 3.0 years; BMI: 23.0 ± 2.9 kg/m2, mean ± SD) finished four study phases, two of normocaloric nutrition, either ambulatory or HDBR, and two of hypocaloric nutrition, either ambulatory or HDBR. Urine samples (24 h) were analyzed for calcium excretion (UCaV) and bone resorption markers (C-Telopeptide, CTX, and N-Telopeptide, NTX). Serum calcium, parathyroid hormone (PTH) and bone formation markers (Procollagen-I-C-terminal-Peptide, PICP, Procollagen-I-N-terminal-Peptide, PINP, and bone-specific alkaline phosphatase, bAP) were analyzed. No significant changes in serum calcium or PTH were noted either during HDBR or during hypocaloric nutrition. PICP, but not PINP or bAP, decreased significantly during HDBR (normocaloric: prestriction did not exaggerate bone resorption during HDBR.

Effect of long-term caloric restriction on brain monoamines in aging male and female Fischer 344 rats.

Science.gov (United States)

Kolta, M G; Holson, R; Duffy, P; Hart, R W

1989-05-01

The present study examines the changes in central monoamines and their metabolites in aged male and female rats after long-term caloric restriction. Fischer 344 rats of both sexes (n = 5-10/group) were maintained on one of two dietary regimens: ad libitum NIH 31 diet or 60% by weight of the ad lib. intake (restricted), supplemented with vitamins and minerals. Animals received these diets from the age of 14 weeks until killed at 22.25 months of age. Caudate nucleus (CN), hypothalamus (HYPO), olfactory bulb (OB) and nucleus accumbens (NA) were assayed for content of norepinephrine (NE), dopamine (DA) and its metabolites (dihydroxyphenylacetic acid, DOPAC, and homovanillic acid, HVA) and serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) using HPLC/EC. Relative to the ad lib. group, restricted rats of both sex showed significant decreases in NE content in CN, HYPO and OB. DA and 5-HT content were decreased significantly in the CN and HYPO. No significant changes were found in the levels of DA metabolites in all brain regions studied. While the 5-HIAA level was significantly reduced in the HYPO and NA of the female restricted rats, it was increased several-fold in the OB of the male restricted animals. These preliminary results suggest that long-term caloric restriction alters brain monoamine concentrations, an effect which may in turn modify the normal rate of aging.

Trends in the development of industrially assimilated renewable energy: the problem of resource restrictions

Science.gov (United States)

Nizhegorodtsev, R. M.; Ratner, S. V.

2016-03-01

An analysis of the dynamics of the development of wind and solar energy and potential resource restrictions of the dissemination of these technologies of energy generation associated with intensive use of rare earth metals and some other mineral resources are presented. The technological prospects of various directions of decisions of the problem of resource restrictions, including escalating of volumes of extraction and production of necessary mineral components, creating substitutes of scarce materials and development of recycling are considered. The bottlenecks of each of the above-mentioned decisions were founded. Conclusions are drawn on the prospects of development of the Russian high-tech sectors of the economy in the context of the most probable decisions of the problem of resource restrictions of wind and solar energy. An increase in extraction and production of rare earth metals and some other materials, stimulation of domestic research and development (R&D) to create the permanent magnets of new types and new technologies of wind-powered generation, and reduction of the resource-demand and technology development of recycling the components of power equipment are the most prospective directions of progress. The innovations in these directions will be in demand on the European, Chinese, and North American markets in the near decades due to the end of the life cycle (approximately 30 years) of wind and solar energy projects started at the turn of the 20th-21st centuries (the beginning of exponential growth in plants). The private investors and relevant regional and federal government agencies can use the qualitative characteristics of the dynamics of industrially assimilated renewable energy to choose the most promising investment orientations in energy projects and selection of the most economically sound development methods of energy and related industries.

Restricted second random phase approximations and Tamm-Dancoff approximations for electronic excitation energy calculations

International Nuclear Information System (INIS)

Peng, Degao; Yang, Yang; Zhang, Peng; Yang, Weitao

2014-01-01

In this article, we develop systematically second random phase approximations (RPA) and Tamm-Dancoff approximations (TDA) of particle-hole and particle-particle channels for calculating molecular excitation energies. The second particle-hole RPA/TDA can capture double excitations missed by the particle-hole RPA/TDA and time-dependent density-functional theory (TDDFT), while the second particle-particle RPA/TDA recovers non-highest-occupied-molecular-orbital excitations missed by the particle-particle RPA/TDA. With proper orbital restrictions, these restricted second RPAs and TDAs have a formal scaling of only O(N 4 ). The restricted versions of second RPAs and TDAs are tested with various small molecules to show some positive results. Data suggest that the restricted second particle-hole TDA (r2ph-TDA) has the best overall performance with a correlation coefficient similar to TDDFT, but with a larger negative bias. The negative bias of the r2ph-TDA may be induced by the unaccounted ground state correlation energy to be investigated further. Overall, the r2ph-TDA is recommended to study systems with both single and some low-lying double excitations with a moderate accuracy. Some expressions on excited state property evaluations, such as 〈S ^2 〉 are also developed and tested

Restricted second random phase approximations and Tamm-Dancoff approximations for electronic excitation energy calculations

Energy Technology Data Exchange (ETDEWEB)

Peng, Degao; Yang, Yang; Zhang, Peng [Department of Chemistry, Duke University, Durham, North Carolina 27708 (United States); Yang, Weitao, E-mail: weitao.yang@duke.edu [Department of Chemistry and Department of Physics, Duke University, Durham, North Carolina 27708 (United States)

2014-12-07

In this article, we develop systematically second random phase approximations (RPA) and Tamm-Dancoff approximations (TDA) of particle-hole and particle-particle channels for calculating molecular excitation energies. The second particle-hole RPA/TDA can capture double excitations missed by the particle-hole RPA/TDA and time-dependent density-functional theory (TDDFT), while the second particle-particle RPA/TDA recovers non-highest-occupied-molecular-orbital excitations missed by the particle-particle RPA/TDA. With proper orbital restrictions, these restricted second RPAs and TDAs have a formal scaling of only O(N{sup 4}). The restricted versions of second RPAs and TDAs are tested with various small molecules to show some positive results. Data suggest that the restricted second particle-hole TDA (r2ph-TDA) has the best overall performance with a correlation coefficient similar to TDDFT, but with a larger negative bias. The negative bias of the r2ph-TDA may be induced by the unaccounted ground state correlation energy to be investigated further. Overall, the r2ph-TDA is recommended to study systems with both single and some low-lying double excitations with a moderate accuracy. Some expressions on excited state property evaluations, such as 〈S{sup ^2}〉 are also developed and tested.

Effect of short-term food restriction on iron metabolism, relative well-being and depression symptoms in healthy women.

Science.gov (United States)

Wojciak, Rafal W

2014-01-01

The idea that iron deficiency anemia can be recognized in depressive patients has been around for a few years, as well as negative association between ferritin levels and depression. Iron deficiency anemia, associated with low iron intake, has been observed in women using restriction diets, for example in vegetarians or anorexics. There are no data on the influence of the short-term food restrictions, observed for example in slimming women, on iron management and its connection with behavior expressed via changes in the subject's emotional state. This study describes the effect of one- and two-day food restrictions (every 8 days for a period of 48 days) on selected iron management parameters in the serum and blood of 46 healthy volunteer women (23 in each group), aged 25.5 ± 3.0 years, in association with the subjects' self-described emotional status and depression symptoms. The association between iron parameters and depression was also analyzed. Results show that short-term (2 days) fasting significantly decreases iron concentrations in serum and hair, as well as levels of ferritin, hemoglobin, hematocrit, red blood cells, and total iron binding capacity, but the short-term fasting did not influence the other iron management parameters. Each model of food restrictions also increased negative feelings towards depression. A significant negative correlation between serum ferritin levels and depression was found in women who starved for 2 days. The study shows that, through an impact on mineral levels, even short-term food restrictions, as observed in many slimming women and girls, can be a reason for iron deficiency and also can alter the emotional status of healthy women. Maybe depression symptoms in anorexia or other eating disorders patients can be associated with iron deficiencies.

Modeling and analysis of long term energy demands in residential sector of pakistan

International Nuclear Information System (INIS)

Rashid, T.; Sahir, M.H.

2015-01-01

Residential sector is the core among the energy demand sectors in Pakistan. Currently, various techniques are being used worldwide to assess future energy demands including integrated system modeling (ISM). Therefore, the current study is focused on implementation of ISM approach for future energy demand analysis of Pakistan's residential sector in terms of increase in population, rapid urbanization, household size and type, and increase/decrease in GDP. A detailed business-as-usual (BAU) model is formulated in TIMES energy modeling framework using different factors like growth in future energy services, end-use technology characterization, and restricted fuel supplies. Additionally, the developed model is capable to compare the projected energy demand under different scenarios e.g. strong economy, weak economy and energy efficiency. The implementation of ISM proved a viable approach to predict the future energy demands of Pakistan's residential sector. Furthermore, the analysis shows that the energy consumption in the residential sector would be 46.5 Mtoe (Million Ton of Oil Equivalent) in 2040 compared to 23 Mtoe of the base year (2007) along with 600% increase in electricity demands. The study further maps the potential residential energy policies to congregate the future demands. (author)

Asthma in children in relation to pre-term birth and fetal growth restriction.

Science.gov (United States)

Koshy, Gibby; Akrouf, Kafya A S; Kelly, Yvonne; Delpisheh, Ali; Brabin, Bernard J

2013-08-01

To assess the impact of parental asthma on risk of pre-term birth (PTB) and intrauterine growth restriction, and their subsequent association with childhood asthma. Three sequential cross-sectional surveys were conducted in 1993 (3,746), 1998 (1,964) and 2006 (1,074) in the same 15 schools among 5-11 year old children in Merseyside using the same respiratory health questionnaire completed by parents (sample size in brackets). Between 1993 and 2006, prevalence of PTB varied between 12.4 and 15.2 %, and of small for gestational age (SGA or growth restricted) babies between 2.1 and 4.6 %, and maternal asthma prevalence between 8.1 and 13.4 %. For the combined surveys mothers with asthma were more likely to have a PTB than non-asthmatic mothers (OR 1.39, 95 % CI 1.10-1.95, p PTBs of asthmatic mothers developed doctor diagnosed asthma compared to 34.3 % for term babies (adjusted OR 1.65, 1.34-2.04, p < 0.001). The corresponding estimates for the symptom triad of cough, wheeze and breathlessness were 19.4 and 17.6 % (adjusted OR 1.78, 0.79-3.98). Conversely SGA babies were less likely to develop doctor diagnosed asthma (adjusted OR 0.49, 0.27-0.90, p < 0.021), or the symptom triad of cough, wheeze and breathlessness (adjusted OR 0.22, 0.05-0.97, p < 0.043), whether or not the mother was asthmatic. Maternal asthma is an independent risk factor for PTB which predisposes to childhood asthma. Intrauterine growth restriction was protective against childhood asthma.

Energy Analysis in the Elliptic Restricted Three-body Problem

Science.gov (United States)

Qi, Yi; de Ruiter, Anton

2018-05-01

The gravity assist or flyby is investigated by analyzing the inertial energy of a test particle in the elliptic restricted three-body problem (ERTBP), where two primary bodies are moving in elliptic orbits. Firstly, the expression of the derivation of energy is obtained and discussed. Then, the approximate expressions of energy change in a circular neighborhood of the smaller primary are derived. Numerical computation indicates that the obtained expressions can be applied to study the flyby problem of the nine planets and the Moon in the solar system. Parameters related to the flyby are discussed analytically and numerically. The optimal conditions, including the position and time of the periapsis, for a flyby orbit are found to make a maximum energy gain or loss. Finally, the mechanical process of a flyby orbit is uncovered by an approximate expression in the ERTBP. Numerical computations testify that our analytical results well approximate the mechanical process of flyby orbits obtained by the numerical simulation in the ERTBP. Compared with the previous research established in the patched-conic method and numerical calculation, our analytical investigations based on a more elaborate derivation get more original results.

Adipose gene expression response of lean and obese mice to short-term dietary restriction.

NARCIS (Netherlands)

Schothorst, Evert M van; Keijer, Jaap; Pennings, Jeroen L A; Opperhuizen, Antoon; Brom, Charissa E van den; Kohl, Thomas; Franssen-van Hal, Nicole L W; Hoebee, Barbara

2006-01-01

Overweight and obesity lead to higher morbidity risks, which are alleviated even by mild weight loss. To gain insight in the molecular effects of weight loss in adipose tissue, we analyzed the effects of short-term dietary restriction (DR) on mice fed a low-fat diet (lean mice) or a high-fat diet

The latest dictionary of nuclear energy term

International Nuclear Information System (INIS)

1996-06-01

This book is the latest dictionary of nuclear energy term. It deals with explanations of nuclear energy term in alphabetical order. It also lists abbreviation of nuclear energy term. This book contains symbol and unit, radiation units, greek letters, the symbol of for element, the table of an isotope and the periodic table on nuclear power term. It includes glossary of nuclear power in Korean and French and conceptual map about development of nuclear power.

10 CFR 725.23 - Terms and conditions of access.

Science.gov (United States)

2010-01-01

... warranty or other representation, expressed or implied, (1) with respect to the accuracy, completeness or... 10 Energy 4 2010-01-01 2010-01-01 false Terms and conditions of access. 725.23 Section 725.23 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.23 Terms and conditions...

Analysis of long-term energy scenarios

Energy Technology Data Exchange (ETDEWEB)

Lemming, J.; Morthorst, P.E.

1998-09-01

When addressing the role of fusion energy in the 21. century, the evaluation of possible future structures in the electricity market and the energy sector as a whole, can be a useful tool. Because fusion energy still needs demonstration, commercialized fusion energy is not likely to be a reality within the next few decades. Therefore long-term scenarios are needed describing the energy markets, which fusion energy eventually will be part of. This report performs an analysis of two of the most detailed existing long-term scenarios describing possible futures of the energy system. The aim is to clarify the frames in which the future development of the global energy demand, as well as the structure of the energy system can be expected to develop towards the year 2100. (au) 19 refs.

Reduced insulin-like growth factor-I serum levels in formerly obese women subjected to laparoscopic-adjustable gastric banding or diet-induced long-term caloric restriction.

Science.gov (United States)

Mitterberger, Maria C; Mattesich, Monika; Klaver, Elise; Piza-Katzer, Hildegunde; Zwerschke, Werner

2011-11-01

Life-span extension in laboratory rodents induced by long-term caloric restriction correlates with decreased serum insulin-like growth factor-I (IGF-I) levels. Reduced activity of the growth hormone/IGF-I signaling system slows aging and increases longevity in mutant mouse models. In the present study, we show that long-term caloric restriction achieved by two different interventions for 4 years, either laparoscopic-adjustable gastric banding or reducing diet, leads to reduced IGF-I serum levels in formerly obese women relative to normal-weight women eating ad libitum. Moreover, we present evidence that the long-term caloric restriction interventions reduce fasting growth hormone serum levels. The present study indicates that the activity of the growth hormone/IGF-I axis is reduced in long-term calorically restricted formerly obese humans. Furthermore, our findings suggest that the duration and severity of the caloric restriction intervention are important for the outcome on the growth hormone/IGF-I axis in humans.

Energy in 2010 - 2020. Long term challenges; Energie 2010-2020. Les defis du long terme

Energy Technology Data Exchange (ETDEWEB)

Dessus, Benjamin [ed.] [Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France)

2000-02-02

This report presents the results of a workshop intending to anticipate the long term challenges, to guide better the short term power options, to understand the available political, economical and technical assumptions for the prospective world situation, to give some strategic hints on the necessary transition. Indeed, the difficult issue which the workshop tried to tackle was how should we prepare to reveal the energetic challenge of the development of the eight to ten billion inhabitants of our Planet in the next century without jeopardizing its existence. The energetic problems, a hardcore of the international preoccupation of both growth and environment, as it was recently evidenced by the climatic conference in Kyoto, have ever been the object of a particular attention on the part of General Commissariat of Plan. Thus, the commission 'Energy in 2010 - 2020' has been instituted in April 1996 in order to update the works done in 1990 - 1991 by the commission 'Energy 2010'. Soon it occurred to this new commission the task of illuminating its works by a long term (2050 - 2100) world prospective analysis of the challenges and problems linked to energy, growth and environment. In conclusion, this document tried to find answers to questions like: - which are the risks the energy consumption augmentation entail? - can we control them by appropriate urbanism and transport policies or technological innovation?. Four options for immediate action are suggested: - the energy efficiency should become a priority objective of policies; -coping with the long term challenges requires acting at present; - building the transition between governmental leadership and market; - taking profit of all the possible synergies between short and long term planning.

Insulin sensitivity is normalized in the third generation (F3 offspring of developmentally programmed insulin resistant (F2 rats fed an energy-restricted diet

Directory of Open Access Journals (Sweden)

Martin John F

2008-10-01

Full Text Available Abstract Background/Aims The offspring and grandoffspring of female rats fed low protein diets during pregnancy and lactation, but fed nutritionally adequate diets thereafter, have been shown to exhibit altered insulin sensitivity in adulthood. The current study investigates the insulin sensitivity of the offspring and grandoffspring of female rats fed low protein diets during pregnancy, and then maintained on energy-restricted diets post weaning over three generations. Methods Female Sprague Dawley rats (F0 were mated with control males and protein malnourished during pregnancy/lactation. F1 offspring were then weaned to adequate but energy-restricted diets into adulthood. F1 dams were fed energy-restricted diets throughout pregnancy/lactation. F2 offspring were also fed energy-restricted diets post weaning. F2 pregnant dams were maintained as described above. Their F3 offspring were split into two groups; one was maintained on the energy-restricted diet, the other was maintained on an adequate diet consumed ad libitum post weaning. Results F2 animals fed energy-restricted diets were insulin resistant (p ad libitum postweaning diets (p Conclusion Maternal energy-restriction did not consistently program reduced insulin sensitivity in offspring over three consecutive generations. The reasons for this remain unclear. It is possible that the intergenerational transmission of developmentally programmed insulin resistance is determined in part by the relative insulin sensitivity of the mother during pregnancy/lactation.

Short-term energy outlook, annual supplement 1994

International Nuclear Information System (INIS)

1994-08-01

The Short-Term Energy Outlook Annual Supplement (Supplement) is published once a year as a complement to the Short-Term Energy Outlook (Outlook), Quarterly Projections. The purpose of the Supplement is to review the accuracy of the forecasts published in the Outlook, make comparisons with other independent energy forecasts, and examine current energy topics that affect the forecasts

Short-term energy outlook annual supplement, 1993

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-08-06

The Short-Term Energy Outlook Annual Supplement (supplement) is published once a year as a complement to the Short-Term Energy Outlook (Outlook), Quarterly Projections. The purpose of the Supplement is to review the accuracy of the forecasts published in the Outlook, make comparisons with other independent energy forecasts, and examine current energy topics that affect the forecasts.

Measuring Short-term Energy Security

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

Ensuring energy security has been at the centre of the IEA mission since its inception, following the oil crises of the early 1970s. While the security of oil supplies remains important, contemporary energy security policies must address all energy sources and cover a comprehensive range of natural, economic and political risks that affect energy sources, infrastructures and services. In response to this challenge, the IEA is currently developing a Model Of Short-term Energy Security (MOSES) to evaluate the energy security risks and resilience capacities of its member countries. The current version of MOSES covers short-term security of supply for primary energy sources and secondary fuels among IEA countries. It also lays the foundation for analysis of vulnerabilities of electricity and end-use energy sectors. MOSES contains a novel approach to analysing energy security, which can be used to identify energy security priorities, as a starting point for national energy security assessments and to track the evolution of a country's energy security profile. By grouping together countries with similar 'energy security profiles', MOSES depicts the energy security landscape of IEA countries. By extending the MOSES methodology to electricity security and energy services in the future, the IEA aims to develop a comprehensive policy-relevant perspective on global energy security. This Brochure provides and overview of the analysis and results. Readers interested in an in-depth discussion of methodology are referred to the MOSES Working Paper.

Neonatal morbidity after induction vs expectant monitoring in intrauterine growth restriction at term: a subanalysis of the DIGITAT RCT

NARCIS (Netherlands)

Boers, Kim E.; van Wyk, Linda; van der Post, Joris A. M.; Kwee, Anneke; van Pampus, Maria G.; Spaanderdam, Marc E. A.; Duvekot, Johannes J.; Bremer, Henk A.; Delemarre, Friso M. C.; Bloemenkamp, Kitty W. M.; de Groot, Christianne J. M.; Willekes, Christine; Rijken, Monique; Roumen, Frans J. M. E.; Thornton, Jim G.; van Lith, Jan M. M.; Mol, Ben W. J.; le Cessie, Saskia; Scherjon, Sicco A.

2012-01-01

OBJECTIVE: The Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT) compared induction of labor and expectant management in suspected intrauterine growth restriction (IUGR) at term. In this subanalysis, we report neonatal morbidity between the policies based on the Morbidity

Fiscal 1999 survey report on long-term energy technological strategies and the like. Long-term energy technological strategy survey (Medium-term energy technological strategy survey); 1999 nendo choki energy gijutsu senryaku nado ni kansuru chosa hokokusho. Choki energy gijutsu senryaku chosa (chuki energy gijutsu senryaku chosa)

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

Energy strategies to be implemented under the New Sunshine Program by around 2010 have been compiled, with nation's industrial technological strategies, long-term energy outlook, and the like taken into consideration. The present survey aims to work out medium-term energy technological strategies. In Chapter 2, by conducting studies on the state of energy strategies in the national industry technological strategies as primarily compiled, long-term energy supply and demand outlook, and the history so far of the New Sunshine Program, and social conditions surrounding energy/environmental technologies and energy conditions are arranged in order and then analyzed with a view to deriving social needs. In Chapter 3, in view of the derived social needs, medium-term energy technological strategies are broken down into strategic target details, based on the important regions and major and minor strategic targets of the national industry technological strategies. In Chapter 4, medium-term energy technological strategies are worked out. In Chapter 5, 'basic ideas,' 'measures for promoting technology development,' 'return of the fruits to society' are mentioned as the methods of realizing the strategies. In Chapter 6, surveys and researches are summarized, and future development is predicted. (NEDO)

Maternal Therapy with Ad.VEGF-A165 Increases Fetal Weight at Term in a Guinea-Pig Model of Fetal Growth Restriction.

Science.gov (United States)

Swanson, Anna M; Rossi, Carlo A; Ofir, Keren; Mehta, Vedanta; Boyd, Michael; Barker, Hannah; Ledwozyw, Agata; Vaughan, Owen; Martin, John; Zachary, Ian; Sebire, Neil; Peebles, Donald M; David, Anna L

2016-12-01

In a model of growth-restricted sheep pregnancy, it was previously demonstrated that transient uterine artery VEGF overexpression can improve fetal growth. This approach was tested in guinea-pig pregnancies, where placental physiology is more similar to humans. Fetal growth restriction (FGR) was attained through peri-conceptual nutrient restriction in virgin guinea pigs. Ad.VEGF-A 165 or Ad.LacZ (1 × 10 10 vp) was applied at mid-gestation via laparotomy, delivered externally to the uterine circulation with thermosensitive gel. At short-term (3-8 days post surgery) or at term gestation, pups were weighed, and tissues were sampled for vector spread analysis, VEGF expression, and its downstream effects. Fetal weight at term was increased (88.01 ± 13.36 g; n = 26) in Ad.VEGF-A 165 -treated animals compared with Ad.LacZ-treated animals (85.52 ± 13.00 g; n = 19; p = 0.028). The brain, liver, and lung weight and crown rump length were significantly larger in short-term analyses, as well as VEGF expression in transduced tissues. At term, molecular analyses confirmed the presence of VEGF transgene in target tissues but not in fetal samples. Tissue histology analysis and blood biochemistry/hematological examination were comparable with controls. Uterine artery relaxation in Ad.VEGF-A 165 -treated dams was higher compared with Ad.LacZ-treated dams. Maternal uterine artery Ad.VEGF-A 165 increases fetal growth velocity and term fetal weight in growth-restricted guinea-pig pregnancy.

Proposed energy conservation contingency plan: emergency restrictions on advertising lighting. Authorities, need, rationale, and operation

Energy Technology Data Exchange (ETDEWEB)

1977-04-01

The emergency restrictions on advertising lighting proposed in Energy Conservation Contingency Plan No. 5 of 1977 are presented. A statement is given on the need for rationale and operation of the Contingency Plan.

Fiscal 1999 survey report on long-term energy technological strategies and the like. Long-term energy technological strategy survey (Medium-term energy technological strategy survey); 1999 nendo choki energy gijutsu senryaku nado ni kansuru chosa hokokusho. Choki energy gijutsu senryaku chosa (chuki energy gijutsu senryaku chosa)

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

Energy strategies to be implemented under the New Sunshine Program by around 2010 have been compiled, with nation's industrial technological strategies, long-term energy outlook, and the like taken into consideration. The present survey aims to work out medium-term energy technological strategies. In Chapter 2, by conducting studies on the state of energy strategies in the national industry technological strategies as primarily compiled, long-term energy supply and demand outlook, and the history so far of the New Sunshine Program, and social conditions surrounding energy/environmental technologies and energy conditions are arranged in order and then analyzed with a view to deriving social needs. In Chapter 3, in view of the derived social needs, medium-term energy technological strategies are broken down into strategic target details, based on the important regions and major and minor strategic targets of the national industry technological strategies. In Chapter 4, medium-term energy technological strategies are worked out. In Chapter 5, 'basic ideas,' 'measures for promoting technology development,' 'return of the fruits to society' are mentioned as the methods of realizing the strategies. In Chapter 6, surveys and researches are summarized, and future development is predicted. (NEDO)

Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women

Directory of Open Access Journals (Sweden)

Silvestre R

2004-11-01

Full Text Available Abstract Objective To compare the effects of isocaloric, energy-restricted very low-carbohydrate ketogenic (VLCK and low-fat (LF diets on weight loss, body composition, trunk fat mass, and resting energy expenditure (REE in overweight/obese men and women. Design Randomized, balanced, two diet period clinical intervention study. Subjects were prescribed two energy-restricted (-500 kcal/day diets: a VLCK diet with a goal to decrease carbohydrate levels below 10% of energy and induce ketosis and a LF diet with a goal similar to national recommendations (%carbohydrate:fat:protein = ~60:25:15%. Subjects 15 healthy, overweight/obese men (mean ± s.e.m.: age 33.2 ± 2.9 y, body mass 109.1 ± 4.6 kg, body mass index 34.1 ± 1.1 kg/m2 and 13 premenopausal women (age 34.0 ± 2.4 y, body mass 76.3 ± 3.6 kg, body mass index 29.6 ± 1.1 kg/m2. Measurements Weight loss, body composition, trunk fat (by dual-energy X-ray absorptiometry, and resting energy expenditure (REE were determined at baseline and after each diet intervention. Data were analyzed for between group differences considering the first diet phase only and within group differences considering the response to both diets within each person. Results Actual nutrient intakes from food records during the VLCK (%carbohydrate:fat:protein = ~9:63:28% and the LF (~58:22:20% were significantly different. Dietary energy was restricted, but was slightly higher during the VLCK (1855 kcal/day compared to the LF (1562 kcal/day diet for men. Both between and within group comparisons revealed a distinct advantage of a VLCK over a LF diet for weight loss, total fat loss, and trunk fat loss for men (despite significantly greater energy intake. The majority of women also responded more favorably to the VLCK diet, especially in terms of trunk fat loss. The greater reduction in trunk fat was not merely due to the greater total fat loss, because the ratio of trunk fat/total fat was also significantly reduced during

Short-term energy outlook annual supplement, 1993

International Nuclear Information System (INIS)

1993-01-01

The Energy Information Administration (EIA) prepares quarterly, short-term energy supply, demand, and price projections for publication in February, May, August, and November in the Short-Term Energy Outlook (Outlook). An annual supplement analyzes the performance of previous forecasts, compares recent cases with those of other forecasting services, and discusses current topics related to the short-term energy markets. (See Short-Term Energy Outlook Annual Supplement, DOE/EIA-0202.) The forecast period for this issue of the Outlook extends from the third quarter of 1993 through the fourth quarter of 1994. Values for the second quarter of 1993, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in the Weekly Petroleum Status Report) or are calculated from model simulations using the latest exogenous information available (for example, electricity sales and generation are simulated using actual weather data). The historical energy data are EIA data published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding

The effects of exercise training in addition to energy restriction on functional capacities and body composition in obese adults during weight loss: a systematic review.

Directory of Open Access Journals (Sweden)

Clint T Miller

Full Text Available BACKGROUND: Obesity is associated with impairments of physical function, cardiovascular fitness, muscle strength and the capacity to perform activities of daily living. This review examines the specific effects of exercise training in relation to body composition and physical function demonstrated by changes in cardiovascular fitness, and muscle strength when obese adults undergo energy restriction. METHODS: Electronic databases were searched for randomised controlled trials comparing energy restriction plus exercise training to energy restriction alone. Studies published to May 2013 were included if they used multi-component methods for analysing body composition and assessed measures of fitness in obese adults. RESULTS: Fourteen RCTs met the inclusion criteria. Heterogeneity of study characteristics prevented meta-analysis. Energy restriction plus exercise training was more effective than energy restriction alone for improving cardiovascular fitness, muscle strength, and increasing fat mass loss and preserving lean body mass, depending on the type of exercise training. CONCLUSION: Adding exercise training to energy restriction for obese middle-aged and older individuals results in favourable changes to fitness and body composition. Whilst weight loss should be encouraged for obese individuals, exercise training should be included in lifestyle interventions as it offers additional benefits.

The Effects of Exercise Training in Addition to Energy Restriction on Functional Capacities and Body Composition in Obese Adults during Weight Loss: A Systematic Review

Science.gov (United States)

Miller, Clint T.; Fraser, Steve F.; Levinger, Itamar; Straznicky, Nora E.; Dixon, John B.; Reynolds, John; Selig, Steve E.

2013-01-01

Background Obesity is associated with impairments of physical function, cardiovascular fitness, muscle strength and the capacity to perform activities of daily living. This review examines the specific effects of exercise training in relation to body composition and physical function demonstrated by changes in cardiovascular fitness, and muscle strength when obese adults undergo energy restriction. Methods Electronic databases were searched for randomised controlled trials comparing energy restriction plus exercise training to energy restriction alone. Studies published to May 2013 were included if they used multi-component methods for analysing body composition and assessed measures of fitness in obese adults. Results Fourteen RCTs met the inclusion criteria. Heterogeneity of study characteristics prevented meta-analysis. Energy restriction plus exercise training was more effective than energy restriction alone for improving cardiovascular fitness, muscle strength, and increasing fat mass loss and preserving lean body mass, depending on the type of exercise training. Conclusion Adding exercise training to energy restriction for obese middle-aged and older individuals results in favourable changes to fitness and body composition. Whilst weight loss should be encouraged for obese individuals, exercise training should be included in lifestyle interventions as it offers additional benefits. PMID:24409219

Investigation into the acute effects of total and partial energy restriction on postprandial metabolism among overweight/obese participants.

Science.gov (United States)

Antoni, Rona; Johnston, Kelly L; Collins, Adam L; Robertson, M Denise

2016-03-28

The intermittent energy restriction (IER) approach to weight loss involves short periods of substantial (75-100 %) energy restriction (ER) interspersed with normal eating. This study aimed to characterise the early metabolic response to these varying degrees of ER, which occurs acutely and prior to weight loss. Ten (three female) healthy, overweight/obese participants (36 (SEM 5) years; 29·0 (sem 1·1) kg/m2) took part in this acute three-way cross-over study. Participants completed three 1-d dietary interventions in a randomised order with a 1-week washout period: isoenergetic intake, partial 75 % ER and total 100 % ER. Fasting and postprandial (6-h) metabolic responses to a liquid test meal were assessed the following morning via serial blood sampling and indirect calorimetry. Food intake was also recorded for two subsequent days of ad libitum intake. Relative to the isoenergetic control, postprandial glucose responses were increased following total ER (+142 %; P=0·015) and to a lesser extent after partial ER (+76 %; P=0·051). There was also a delay in the glucose time to peak after total ER only (P=0·024). Both total and partial ER interventions produced comparable reductions in postprandial TAG responses (-75 and -59 %, respectively; both Pobese participants. Further investigations are required to establish how metabolism adapts over time to the repeated perturbations experienced during IER, as well as the implications for long-term health.

Effects of a short-term feed restriction on growth performance, blood metabolites and hepatic IGF-1 levels in growing rabbits

Directory of Open Access Journals (Sweden)

J. Lu

2017-09-01

Full Text Available A total of 144 weaned hybrid HYLA rabbits (40-day-old were randomly divided into 4 groups, to investigate the effects of the intensity of one week’s feed restriction on short- and medium-term growth performance, blood metabolites and hepatic IGF-1 in growing rabbits. Restricted groups were fed with 30% (Group L30, 50% (Group L50 70% (Group L70 of ad libitum feeding for 1 wk and then fed ad libitum until the end of the experiment (75 d of age. The control group (Group AL was fed ad libitum throughout the experiment. Total feed intake (–15.8% and feed conversion ratio (–13.2% were lower in the L50 than in the AL group (P0.05 for these parameters. Total weight gain did not significantly differ among the 4 experimental groups (38.5 g/d; P>0.05. At the end of the feed restriction period, the total serum protein level (P=0.01 was higher in restricted rabbits than AL rabbits (P0.05 throughout the experiment. In conclusion, a short-term feed restriction improves feed conversion ratio in a lasting way, transiently alters serum protein and IFG-1 levels and leads to compensatory growth in growing rabbits.

Nuclear Energy, Long Term Requirements

International Nuclear Information System (INIS)

Knapp, V.

2006-01-01

There are serious warnings about depletion of oil and gas and even more serious warnings about dangers of climate change caused by emission of carbon dioxide. Should developed countries be called to replace CO2 emitting energy sources as soon as possible, and the time available may not be longer then few decades, can nuclear energy answer the call and what are the requirements? Assuming optimistic contribution of renewable energy sources, can nuclear energy expand to several times present level in order to replace large part of fossil fuels use? Paper considers intermediate and long-term requirements. Future of nuclear power depends on satisfactory answers on several questions. First group of questions are those important for near and intermediate future. They deal with economics and safety of nuclear power stations in the first place. On the same time scale a generally accepted concept for radioactive waste disposal is also required. All these issues are in the focus of present research and development. Safer and more economical reactors are targets of international efforts in Generation IV and INPRO projects, but aiming further ahead these innovative projects are also addressing issues such as waste reduction and proliferation resistance. However, even assuming successful technical development of these projects, and there is no reason to doubt it, long term and large-scale nuclear power use is thereby not yet secured. If nuclear power is to play an essential role in the long-term future energy production and in reduction of CO2 emission, than several additional questions must be replied. These questions will deal with long-term nuclear fuel sufficiency, with necessary contribution of nuclear power in sectors of transport and industrial processes and with nuclear proliferation safety. This last issue is more political then technical, thus sometimes neglected by nuclear engineers, yet it will have essential role for the long-term prospects of nuclear power. The

Effect of energy restriction and re-alimentation in Belgian Blue double-muscled beef cows on digestibility and metabolites.

Science.gov (United States)

Fiems, L O; Vanacker, J M; De Boever, J L; van Caelenbergh, W; Aerts, J M; De Brabander, D L

2007-02-01

Four groups of five non-lactating and non-pregnant Belgian Blue double-muscled (BBDM) cows were used to investigate the effect of energy level (E) on digestion, and blood and urine metabolites. The energy levels of the groups, applied indoors during a 140-day restriction period, were 100%, 90%, 80% or 70% of their energy requirements (E100, E90, E80, E70) respectively. Afterwards, animals grazed on the same swards for 203 days (re-alimentation period). Balance trials were conducted at the end of the restriction period (BT1) and at the end of the re-alimentation period (BT2). Blood was sampled at the end of these trials. Diets consisted of maize silage and straw (80/20 on a dry matter basis) and a mineral-vitamin premix, fed at the appropriate E during BT1, or maize silage and a mineral-vitamin premix, fed at 125% of the maintenance requirements, during BT2. Significant increases of the digestibility coefficients were found during BT1 when E decreased, resulting in a better net energy capture of 7% for E70 compared with E100 (p < 0.05). Slightly, but non-significantly higher digestibility coefficients were observed for decreasing E during BT2. Plasma concentrations of glucose and creatinine did not differ between treatments during BT1, while differences were found for triacylglycerols and alpha-amino nitrogen. A tendency for a linear increase was observed for non-esterified fatty acids with decreasing E. Differences in blood metabolite concentrations disappeared in BT2. Urinary creatinine excretion was not affected by E, while body nitrogen loss increased linearly with energy restriction in BT1. No differences were found during BT2, suggesting that non-lactating and non-pregnant BBDM cows are able to adapt to a cyclic change of body weight and body reserves. These data show that restricted cows mobilized body fat as well as body protein. It is concluded that the qualitative aspects of metabolism during energy restriction are comparable in double-muscled cows with

Maternal HY-restricting HLA class II alleles are associated with poor long-term outcome in recurrent pregnancy loss after a boy

DEFF Research Database (Denmark)

Kolte, Astrid Marie; Steffensen, Rudi; Christiansen, Ole Bjarne

2016-01-01

PROBLEM: Women with secondary recurrent pregnancy loss (RPL) after a boy have a reduced chance of live birth in the first pregnancy after referral if they carry HY-restricting HLA class II alleles, but long-term chance of live birth is unknown. METHODS OF STUDY: Live birth was compared for 540...... women with unexplained secondary RPL according to firstborn's sex and maternal carriage of HLA-DRB3*03:01, HLA-DQB1*05:01/02, HLA-DRB1*15, and HLA-DRB1*07. The groups were compared by Cox proportional hazard ratios. RESULTS: For women with at firstborn boy, maternal carriage of HY-restricting HLA class...... of HY-restricting HLA class II alleles decreases long-term chance of live birth in women with RPL after a boy....

Impacts of high energy prices on long-term energy-economic scenarios for Germany

Energy Technology Data Exchange (ETDEWEB)

Krey, V.; Markewitz, P. [Research Center Juelich, Inst. of Energy Res., Systems Analysis and Technology Evaluation, Juelich (Germany); Horn, M. [DIW Berlin, Berlin (Germany); Matthes, C.; Graichen, V.; Harthan, R.O.; Repenning, J. [Oeko-Institut, Berlin (Germany)

2007-05-15

Prices of oil and other fossil fuels on global markets have reached a high level in recent years. These levels were not able to be reproduced on the basis of scenarios and prognoses that were published in the past. New scenarios, based on higher energy price trajectories, have appeared only recently. The future role of various energy carriers and technologies in energy-economic scenarios will greatly depend on the level of energy prices. Therefore, an analysis of the impact of high energy prices on long-term scenarios for Germany was undertaken. Based on a reference scenario with moderate prices, a series of consistent high price scenarios for primary and secondary energy carriers were developed. Two scenarios with (i) continuously rising price trajectories and (ii) a price shock with a price peak during the period 2010-15 and a subsequent decline to the reference level are analysed. Two types of models have been applied in the analysis. The IKARUS energy systems optimisation model covers the whole of the German energy system from primary energy supply down to the end-use sectors. Key results in both high price scenarios include a replacement of natural gas by hard coal and renewable energy sources in electricity and heat generation. Backstop technologies like coal liquefaction begin to play a role under such conditions. Up to 10% of final energy consumption is saved in the end-use sectors, with the residential and transport sector being the greatest contributors. Even without additional restrictions, CO{sub 2} emissions significantly drop in comparison to the reference scenario. The ELIAS electricity investment analysis model focuses on the power sector. In the reference scenario with current allocation rules in the emissions trading scheme, the CO{sub 2} emissions decrease relatively steadily. The development is characterised by the phaseout of nuclear energy which is counterweighted by the increase of renewable. In the high price scenario, the CO{sub 2

History of Physical Terms: "Energy"

Science.gov (United States)

Frontali, Clara

2014-01-01

Difficulties encountered by teachers in giving a definition of the term "energy", and by students in grasping its actual meaning, reflect the lengthy process through which the concept eventually came to maturity around 1850. Tracing the history of this process illuminates the different aspects covered by the term and shows the important…

Nutritional adequacy of energy restricted diets for young obese women.

Science.gov (United States)

O'Connor, Helen; Munas, Zahra; Griffin, Hayley; Rooney, Kieron; Cheng, Hoi Lun; Steinbeck, Katharine

2011-01-01

Energy restricted meal plans may compromise nutrient intake. This study used diet modelling to assess the nutritional adequacy of energy restricted meal plans designed for weight management in young obese women. Diet modelling of 6000 kJ/d animal protein based meal plans was performed using Australian nutrient databases with adequacy compared to the Australian Nutrient Reference Values (NRVs) for women (19-30 years). One diet plan was based on the higher carbohydrate (HC) version of the Australian Guide to Healthy Eating for women 19-60 years. An alternative higher protein (HP) plan was adapted from the CSIRO Total Wellbeing Diet. Vegan and lacto-ovo versions of these plans were also modelled and compared to the appropriate vegetarian NRVs. Both animal protein diets met the estimated average requirement (EAR) or adequate intake (AI) for all nutrients analysed. The recommended dietary intake (RDI) was also satisfied, except for iron. HC met 75±30% and HP 81±31% of the iron RDI when red meat and iron fortified cereal were both included three days a week, and remained below the RDI even when red meat was increased to seven days. Iron for the modified vegan (57±5% HC; 66±4% HP) and lacto-ovo (48±6% HC; 59±7% HP) plans was below the RDI and zinc below the EAR for the vegan (76±8% HC; 84±9% HP) plans. The 6000 kJ/d animal protein meal plans met the RDI for all nutrients except iron. Iron and zinc failed to meet the vegetarian RDI and EAR respectively for the vegan plans.

The energy and stability of D-term strings

International Nuclear Information System (INIS)

Collinucci, Andres; Smyth, Paul; Proeyen, Antoine van

2007-01-01

Cosmic strings derived from string theory, supergravity or any theory of choice should be stable if we hope to observe them. In this paper we consider D-term strings in D = 4 , N = 1 supergravity with a constant Fayet-Iliopoulos term. We show that the positive deficit angle supersymmetric D-term string is non-perturbatively stable by using standard Witten-Nester techniques to prove a positive energy theorem. Particular attention is paid to the negative deficit angle D-term string, which is known to violate the dominant energy condition. Within the class of string solutions we consider, this violation implies that the negative deficit angle D-term string must have a naked pathology and therefore the positive energy theorem we prove does not apply to it. As an interesting aside, we show that the Witten-Nester charge calculates the total gravitational energy of the D-term string without the need for a cut-off, which may not have been expected

Fiscal 1999 survey report on survey of long-term strategy on energy technology. Long-term energy technological strategy survey (Long-term energy technological strategy survey); 1999 nendo choki energy gijutsu senryaku nado ni kansuru chosa hokokusho. Choki energy gijutsu senryaku chosa (choki energy gijutsu senryaku chosa))

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

To enhance still more effectively the research and development of energy-related/environmental technologies, research and development strategies have to be worked out from a long-term view point and policy resources such as investment in research and development should be optimally distributed after clarifying and defining the course to follow toward the achievement of research and development goals. This project aims to conduct studies, and to show the course to follow in the future, towards the establishment of a long-term energy technological strategy by investigating energy systems for around 2050, interim energy systems at the intermediate stage, and innovative energy technologies for realizing such energy systems. In Chapter 1, the position of the survey and its purpose and prerequisites are shown. In Chapter 2, the history of social and economic conditions surrounding energy/environmental technologies and of energy situation up to the present time is compiled, and the outlook is analyzed and predicted. In Chapter 3, formulation of a long-term energy technological strategy is discussed. In Chapter 5, how to embody such a strategy is shown. (NEDO)

Neuropeptide S overcomes short term memory deficit induced by sleep restriction by increasing prefrontal cortex activity.

Science.gov (United States)

Thomasson, Julien; Canini, Frédéric; Poly-Thomasson, Betty; Trousselard, Marion; Granon, Sylvie; Chauveau, Frédéric

2017-12-01

Sleep restriction (SR) impairs short term memory (STM) that might be related to different processes. Neuropeptide S (NPS), an endogenous neuropeptide that improves short term memory, activates arousal and decreases anxiety is likely to counteract the SR-induced impairment of STM. The objective of the present study was to find common cerebral pathways in sleep restriction and NPS action in order to ultimately antagonize SR effect on memory. The STM was assessed using a spontaneous spatial alternation task in a T-maze. C57-Bl/6J male mice were distributed in 4 groups according to treatment (0.1nmol of NPS or vehicle intracerebroventricular injection) and to 20h-SR. Immediately after behavioural testing, regional c-fos immunohistochemistry was performed and used as a neural activation marker for spatial short term memory (prefrontal cortex, dorsal hippocampus) and emotional reactivity (basolateral amygdala and ventral hippocampus). Anxiety-like behaviour was assessed using elevated-plus maze task. Results showed that SR impaired short term memory performance and decreased neuronal activation in cingular cortex.NPS injection overcame SR-induced STM deficits and increased neuronal activation in infralimbic cortex. SR spared anxiety-like behavior in the elevated-plus maze. Neural activation in basolateral nucleus of amygdala and ventral hippocampus were not changed after SR.In conclusion, the present study shows that NPS overcomes SR-induced STM deficits by increasing prefrontal cortex activation independently of anxiety-like behaviour. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Short-term meal replacements followed by dietary macronutrient restriction enhance weight loss in polycystic ovary syndrome.

Science.gov (United States)

Moran, Lisa J; Noakes, Manny; Clifton, Peter M; Wittert, Gary A; Williams, Gemma; Norman, Robert J

2006-07-01

Polycystic ovary syndrome (PCOS), a common condition in women, improves with weight loss. Meal replacements in short-term weight loss and strategies for weight maintenance have not been investigated in PCOS. We compared in overweight women with PCOS the effects of meal replacements in short-term weight-loss and longer-term carbohydrate- or fat-restriction strategies on weight maintenance and improvements in reproductive and metabolic variables. Overweight women with PCOS (n = 43; x +/- SD age: 32.1 +/- 5.2 y; weight: 96.1 +/- 18.4 kg) followed an 8-wk weight-loss regimen (2 meal replacements/d, 4904.4 +/- 127 kJ; phase 1) and then a 6-mo weight-maintenance carbohydrate- (weight (5.6 +/- 2.4 kg), waist circumference (6.1 +/- 2.5 cm), body fat (4.1 +/- 2.2 kg), insulin (2.8 +/- 1.1 mU/L), total testosterone (0.3 +/- 0.7 nmol/L), and free androgen index (3.1 +/- 4.6) occurred; these changes were sustained during phase 2. No significant differences between diet groups were seen for any variables. At 6 mo, both approaches resulted in a net weight loss of 4.7 +/- 4.6 kg. Improvements in menstrual cyclicity occurred for 16 (57.1%) of 28 subjects. Meal replacements are an effective strategy for the short-term management of PCOS. Advice on moderate fat or carbohydrate restriction was equally effective in maintaining weight reduction and improving reproductive and metabolic variables.

Designing indicators of long-term energy supply security

International Nuclear Information System (INIS)

Jansen, J.C.; Van Arkel, W.G.; Boots, M.G.

2004-01-01

To our knowledge, so far amazingly little research work has been undertaken to construct meaningful indicators of long-run energy supply security for a particular nation or region. Currently, in addressing energy supply security, policy makers tend to emphasise short-term supply disruptions. In contrast, this pre-study accords with the broader Sustainability Outlook in considering the long-term perspective. This report starts with taking stock, in a concise way, of the official EU energy outlook and issues related to the opportunities to administer changes in the energy mix at the level of major energy use categories. Then a brief survey of relevant literature is made on long-term strategies to ensure survival of systems - be it biological, social, etc. - in an environment largely characterised by high uncertainty and a lot of unchartered territory. We found the work of Andrew Stirling very inspiring in this context. Based on his work and considering the limitations of the present research activity, we retained the Shannon index as the best 'simple' indicator of diversity. In the core of the report, the Shannon index is elaborated into four indicators of long-term energy supply security. Stepwise, additional aspects of long-term energy supply security are introduced. These aspects are: Diversification of energy sources in energy supply; Diversification of imports with respect to imported energy sources; Long-term political stability in regions of origin; The resource base in regions of origin, including the home region/country itself. After small adjustments to allow for data availability, these indicators were applied to the reference year 2030 of four long-term scenarios with data of base year 1995 and projections for underlying variables provided by the Netherlands Environmental Assessment Agency (MNP). Preliminary interpretation of the results suggests the usefulness of the indicators presented in this report. A second activity undertaken in this report was

Possibilities and restrictions of wind energy use in one federal state in Germany

International Nuclear Information System (INIS)

Kaltschmitt, M.

1992-01-01

This paper discusses a current political topic, the request for increasing use of wind energy. The objectives of this paper are to evaluate this call in more detail in some parts of the Federal Republic of Germany by analyzing possibilities, restrictions, and production costs of electricity generation from wind energy in Baden-Wurttemberg, an inland state in the southwest of Germany. Based on zones with similar average wind velocities, the theoretical potential to install converters is assessed for each municipality, considering among other things residential areas, highways, roads, rivers, and nature conservation areas as not usable territories. The result is a technical area potential suitable for the installation of wind energy converters. Based on this area potential, a methodological approach is presented that allows the definition and the analysis of strategies of a wind energy use on a high spatial and timely resolution

Effects of energy restriction on acute adrenoceptor and metabolic responses to exercise in obese subjects

NARCIS (Netherlands)

Kempen, K.P.G.; Saris, W.H.M.; Senden, J.M.G.; Menheere, P.P.C.A.; Blaak, E.E.; van Baak, M.A.

1994-01-01

Effects of energy restriction on acute adrenoceptor and metabolic responses to exercise in obese subjects. Kempen KP, Saris WH, Senden JM, Menheere PP, Blaak EE, van Baak MA. Department of Human Biology, University of Limburg, Maastricht, The Netherlands. This study was intended to investigate the

Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing

Science.gov (United States)

Seals, Douglas R.

2016-01-01

Abstract Calorie restriction (CR) in the absence of malnutrition exerts a multitude of physiological benefits with ageing in model organisms and in humans including improvements in vascular function. Despite the well‐known benefits of chronic CR, long‐term energy restriction is not likely to be a feasible healthy lifestyle strategy in humans due to poor sustained adherence, and presents additional concerns if applied to normal weight older adults. This review summarizes what is known about the effects of CR on vascular function with ageing including the underlying molecular ‘energy‐ and nutrient‐sensing’ mechanisms, and discusses the limited but encouraging evidence for alternative pharmacological and lifestyle interventions that may improve vascular function with ageing by mimicking the beneficial effects of long‐term CR. PMID:27641062

Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects—A Narrative Review of Human and Animal Evidence

OpenAIRE

Howell, Anthony; Harvie, Michelle

2017-01-01

Intermittent energy restriction (IER) has become popular as a means of weight control amongst people who are overweight and obese, and is also undertaken by normal weight people hoping spells of marked energy restriction will optimise their health. This review summarises randomised comparisons of intermittent and isoenergetic continuous energy restriction for weight loss to manage overweight and obesity. It also summarises the potential beneficial or adverse effects of IER on body composition...

Low inflation, a high net savings surplus and institutional restrictions keep the Japanese long-term interest rate low

NARCIS (Netherlands)

Jansen, Pieter W.

2006-01-01

This paper explains that the interest rate on long-term Japanese government bonds is low in comparison with other industrialised countries for four main reasons: lower inflation, net savings surplus, institutional restrictions and home bias. Monetary policy and institutionalised purchases of

Appetite and gut peptide responses to exercise and calorie restriction. The effect of modest energy deficits.

Science.gov (United States)

Deighton, Kevin; Batterham, Rachel L; Stensel, David J

2014-10-01

Weight loss is the result of a sustained negative energy balance, which is typically achieved by decreasing food intake and/or increasing physical activity. Current evidence suggests that acute energy deficits of ~4820 kJ elicit contrasting homeostatic responses when induced by exercise and food restriction but the response to government-recommended energy deficits is unknown. Twelve healthy men (mean(SD): age 24(5) years, body mass index 23.8(2.7) kg⋅m(-2), maximum oxygen uptake 55.4(9.1) mL⋅kg(-1)⋅min(-1)) completed three 8 h trials (control (Con), exercise-induced energy deficit (Ex-Def) and food restriction (Food-Def)) separated by 1 week. Thirty minutes of cycling at 64.5(3.2)% of maximum oxygen uptake was performed in Ex-Def from 0 to 0.5 h, which induced an energy deficit of 1469(256) kJ. An equivalent energy deficit was induced in Food-Def (1478(275) kJ) by reducing the energy content of standardised test meals at 1 h and 4 h. Appetite ratings, acylated ghrelin and peptide YY3-36 concentrations were measured throughout each trial. An ad libitum meal was provided at 7 h. Appetite was higher in Food-Def than Ex-Def from 4 to 8 h (P = 0.033) and tended to be higher across the entire 8 h trial (P = 0.059). However, energy intake at the ad libitum meal did not differ between trials (P = 0.634; Con 4376 (1634); Food-Def 4481 (1846); Ex-Def 4217 (1850) kJ). Acylated ghrelin was not related to changes in appetite but plasma PYY3-36 concentrations were higher in Ex-Def than Food-Def (P < 0.05) and negatively correlated with changes in appetite across the entire 8 h trial (P = 0.037). An energy deficit of ~1475 kJ stimulated compensatory increases in appetite when induced via calorie restriction but not when achieved by an acute bout of exercise. Appetite responses were associated with changes in plasma PYY3-36 but not acylated ghrelin concentrations and did not influence subsequent energy intake. Copyright

Beneficial effect of a moderately energy-restricted diet on fibrinolytic factors in non-obese men

NARCIS (Netherlands)

Velthuis-te Wierik, E.J.M.; Meijer, P.; Kluft, C.; Berg, H. van den

1995-01-01

Impaired fibrinolytic activity has been reported in the elderly and is thought to play a role in the etiology of cardiovascular disease, one of the leading causes of death in most Western countries. Since restriction of energy intake has been demonstrated to act beneficially on the aging process in

Increased energy intake following sleep restriction in men and women: A one-size-fits-all conclusion?

Science.gov (United States)

McNeil, Jessica; St-Onge, Marie-Pierre

2017-06-01

This study assessed the degree of interindividual responses in energy intake (EI) to an imposed sleep restriction versus habitual sleep duration protocol. It also investigated participant (age, sex, ethnicity, and BMI) and study (study site and protocol order) characteristics as potential contributors to the variance in EI responses to sleep restriction between individuals. Data from two randomized crossover trials were combined. All participants (n = 43; age: 31 ± 7 years, BMI: 23 ± 2 kg/m 2 ) were free of medical/sleep conditions, were nonsmokers, reported not performing shift work, and had an average sleep duration of 7 to 9 hours per night. Ad libitum, 24-hour EI was objectively assessed following sleep restriction (3.5-4 hours in bed per night) and habitual sleep (7-9 hours in bed per night) conditions. Large interindividual variations in EI change (ΔEI) between restricted and habitual sleep conditions were noted (-813 to 1437 kcal/d). Only phase order was associated with ΔEI (β = -568 kcal/d, 95% confidence interval for β = -921 to -215 kcal/d; P = 0.002); participants randomized to the habitual sleep condition first had greater increases in EI when sleep was restricted (P = 0.01). Large interindividual variations in ΔEI following sleep restriction were noted, suggesting that not all participants were negatively impacted by the effects of sleep restriction. © 2017 The Obesity Society.

Modified weak energy condition for the energy momentum tensor in quantum field theory

International Nuclear Information System (INIS)

Latorre, J.

1998-01-01

The weak energy condition is known to fail in general when applied to expectation values of the energy momentum tensor in flat space quantum field theory. It is shown how the usual counter arguments against its validity are no longer applicable if the states vertical stroke ψ right angle for which the expectation value is considered are restricted to a suitably defined subspace. A possible natural restriction on vertical stroke ψ right angle is suggested and illustrated by two quantum mechanical examples based on a simple perturbed harmonic oscillator Hamiltonian. The proposed alternative quantum weak energy condition is applied to states formed by the action of the scalar, vector and the energy momentum tensor operators on the vacuum. We assume conformal invariance in order to determine almost uniquely three-point functions involving the energy momentum tensor in terms of a few parameters. The positivity conditions lead to non-trivial inequalities for these parameters. They are satisfied in free field theories, except in one case for dimensions close to two. Further restrictions on vertical stroke ψ right angle are suggested which remove this problem. The inequalities which follow from considering the state formed by applying the energy momentum tensor to the vacuum are shown to imply that the coefficient of the topological term in the expectation value of the trace of the energy momentum tensor in an arbitrary curved space background is positive, in accord with calculations in free field theories. (orig.)

Effects of energy and protein restriction, followed by nutritional recovery on morphological development of the gastrointestinal tract of weaned kids.

Science.gov (United States)

Sun, Z H; He, Z X; Zhang, Q L; Tan, Z L; Han, X F; Tang, S X; Zhou, C S; Wang, M; Yan, Q X

2013-09-01

Effects of energy, protein, or both energy and protein restriction on gastrointestinal morphological development were investigated in 60 Liuyang Black kids, which were sourced from local farms and weaned at 28 d of age. Weaned kids were randomly assigned to receive 1 of 4 dietary treatments (15 kids per treatment), which consisted of adequate nutrient supply (CON), energy restriction (ER), protein restriction (PR), or energy and protein restriction (EPR). The entire experiment included adaptation period (0 to 6 d), nutritional restriction period (7 to 48 d), and recovery period (49 to 111 d). Three kids from each group were killed at d 48 and 111, and the rumen, duodenum, jejunum, and ileum were harvested. On d 48 (end of nutritional restriction), lengths of the duodenum (P = 0.005), jejunum (P = 0.003), and ileum (P = 0.003), and weights of the rumen (P = 0.004), duodenum (P = 0.006), jejunum (P = 0.006), and ileum (P = 0.004) of kids in ER, PR, and EPR were less than those of kids in CON. Compared with CON, PR decreased papillae width (P = 0.03) and surface area (P = 0.05) of the rumen epithelium, villus surface area (P = 0.05), and N concentration (P = 0.02) of the jejunum mucosa on d 48. Compared with CON, EPR decreased papillae height (P = 0.001), width (P = 0.001), and surface area (P = 0.003), N concentration (P = 0.01), and the ratio of N to DNA (P = 0.03) of the rumen epithelium. Compared with CON, EPR also decreased villus height (P = 0.01), width (P = 0.006), and surface area (P = 0.006), N concentration (P kids in ER, PR, and EPR were still less than those of kids in CON; N concentrations of rumen epithelium of kids in PR (P = 0.01) and EPR (P = 0.001), and the ratio of N to DNA of jejunum mucosa of kids in EPR (P kids in CON. Results indicate that nutritional restriction of 6 wk can retard gastrointestinal morphological development for kids weaned at 28 d of age and retarded development remains evident, even after nutritional recovery of 9 wk.

RECAP, Replacement Energy Cost for Short-Term Reactor Plant Shut-Down

International Nuclear Information System (INIS)

VanKuiken, J.C.; Daun, C.J.; Jusko, M.J.

1995-01-01

default values for gross national product price deflators unless user-defined cost adjustment factors are entered. 3 - Restrictions on the complexity of the problem: Maximum of 25 case- study files. Care should be exercised in applying the replacement energy cost estimates to shutdowns of a year or more, because in such cases utilities would probably seek more-optimum solutions to the loss of a nuclear unit. Long-term adjustments of this nature are not included in this analysis

Effects of moderate energy restriction on physical performance and substrate utilization in non-obese men

NARCIS (Netherlands)

Velthuis-te Wierik, E.J.M.; Hoogzaad, L.V.; Berg, H. van den; Schaafsma, G.

1994-01-01

Energy restriction (ER) has shown to be an effective 'anti-aging' factor in rodents, resulting in an increased life span and preventing or delaying the occurrence of many age-related diseases in rodents. As a part of a feasibility study on the potential application of ER in humans, we studied the

Positron and electron energy bands in several ionic crystals using restricted Hartree-Fock method

Science.gov (United States)

Kunz, A. B.; Waber, J. T.

1981-08-01

Using a restricted Hartree-Fock formalism and suitably localized and symmetrized wave functions, both the positron and electron energy bands were calculated for NaF, MgO and NiO. The lowest positron state at Γ 1 lies above the vacuum level and negative work functions are predicted. Positron annihilation rates were calculated and found to be in good agreement with measured lifetimes.

Restrictive annuloplasty to treat functional mitral regurgitation: optimize the restriction to improve the results?

Science.gov (United States)

Totaro, Pasquale; Adragna, Nicola; Argano, Vincenzo

2008-03-01

Today, the 'gold standard' treatment of functional mitral regurgitation (MR) is the subject of much discussion. Although restrictive annuloplasty is currently considered the most reproducible technique, the means by which the degree of annular restriction is optimized remains problematic. The study was designed in order to identify whether the degree of restriction of the mitral annulus could influence early and midterm results following the treatment of functional MR using restrictive annuloplasty. A total of 32 consecutive patients with functional MR grade > or = 3+ was enrolled, among whom the mean anterior-posterior (AP) mitral annulus diameter was 39 +/- 3 mm. Restrictive mitral annuloplasty (combined with coronary artery bypass grafting) was performed in all patients using a Carpentier-Edwards Classic or Physio ring (size 26 or 28). The degree of AP annular restriction was calculated for each patient, and correlated with early and mid-term residual MR and left ventricular (LV) reverse remodeling (in terms of LV end-diastolic diameter (LVEDD) and LV end-diastolic volume (LVEDV) reduction). All surviving patients were examined at a one-year follow up. The mean AP mitral annulus restriction achieved was 48 +/- 4%. Intraoperatively, transesophageal echocardiography showed no residual MR in any patient. Before discharge from hospital, transthoracic echocardiography confirmed an absence of residual MR and showed significant LV reverse remodeling (LVEDV from 121 +/- 25 ml to 97 +/- 26 ml; LVEDD from 55 +/- 6 mm to 47 +/- 8 mm). A significant correlation (r = 0.57, p 40% of preoperative) appears to have a favorable influence on early postoperative LV reverse remodeling, and also allows for complete resolution of functional MR. In addition, 'no tolerance' of early residual MR seems to have a favorable influence on mid-term results, leading to a reduction in the one-year recurrence of significant MR.

Restriction on an energy-dense diet improves markers of metabolic health and cellular aging in mice through decreasing hepatic mTOR activity.

Science.gov (United States)

Schloesser, Anke; Campbell, Graeme; Glüer, Claus-Christian; Rimbach, Gerald; Huebbe, Patricia

2015-02-01

Dietary restriction (DR) on a normal low-fat diet improves metabolic health and may prolong life span. However, it is still uncertain whether restriction of an energy-dense, high-fat diet would also be beneficial and mitigate age-related processes. In the present study, we determined biomarkers of metabolic health, energy metabolism, and cellular aging in obesity-prone mice subjected to 30% DR on a high-fat diet for 6 months. Dietary-restricted mice had significantly lower body weights, less adipose tissue, lower energy expenditure, and altered substrate oxidation compared to their ad libitum-fed counterparts. Hepatic major urinary proteins (Mup) expression, which is linked to glucose and energy metabolism, and biomarkers of metabolic health, including insulin, glucose, cholesterol, and leptin/adiponectin ratio, were likewise reduced in high-fat, dietary-restricted mice. Hallmarks of cellular senescence such as Lamp2a and Hsc70 that mediate chaperone-mediated autophagy were induced and mechanistic target of rapamycin (mTOR) signaling mitigated upon high-fat DR. In contrast to DR applied in low-fat diets, anti-oxidant gene expression, proteasome activity, as well as 5'-adenosine monophosphate-activated protein kinase (AMPK) activation were not changed, suggesting that high-fat DR may attenuate some processes associated with cellular aging without the induction of cellular stress response or energy deprivation.

Childhood and adolescent energy restriction and subsequent colorectal cancer risk: Results from The Netherlands cohort study

NARCIS (Netherlands)

Hughes, L.A.E.; Brandt, P.A. van den; Goldbohm, R.A.; Goeij, A.F.P.M. d; Bruïne, A.P. de; Engeland, M. van; Weijenberg, M.P.

2010-01-01

Background: Energy restriction during childhood and adolescence is suggested to lower colorectal cancer (CRC) risk. We investigated this in the Netherlands Cohort Study. Methods: Information on diet and other risk factors was collected by a baseline questionnaire in 1986 when cohort members were

Hamiltonian boundary term and quasilocal energy flux

International Nuclear Information System (INIS)

Chen, C.-M.; Nester, James M.; Tung, R.-S.

2005-01-01

The Hamiltonian for a gravitating region includes a boundary term which determines not only the quasilocal values but also, via the boundary variation principle, the boundary conditions. Using our covariant Hamiltonian formalism, we found four particular quasilocal energy-momentum boundary term expressions; each corresponds to a physically distinct and geometrically clear boundary condition. Here, from a consideration of the asymptotics, we show how a fundamental Hamiltonian identity naturally leads to the associated quasilocal energy flux expressions. For electromagnetism one of the four is distinguished: the only one which is gauge invariant; it gives the familiar energy density and Poynting flux. For Einstein's general relativity two different boundary condition choices correspond to quasilocal expressions which asymptotically give the ADM energy, the Trautman-Bondi energy and, moreover, an associated energy flux (both outgoing and incoming). Again there is a distinguished expression: the one which is covariant

Prenatal programming in an obese swine model: sex-related effects of maternal energy restriction on morphology, metabolism and hypothalamic gene expression.

Science.gov (United States)

Óvilo, Cristina; González-Bulnes, Antonio; Benítez, Rita; Ayuso, Miriam; Barbero, Alicia; Pérez-Solana, Maria L; Barragán, Carmen; Astiz, Susana; Fernández, Almudena; López-Bote, Clemente

2014-02-01

Maternal energy restriction during pregnancy predisposes to metabolic alterations in the offspring. The present study was designed to evaluate phenotypic and metabolic consequences following maternal undernutrition in an obese pig model and to define the potential role of hypothalamic gene expression in programming effects. Iberian sows were fed a control or a 50 % restricted diet for the last two-thirds of gestation. Newborns were assessed for body and organ weights, hormonal and metabolic status, and hypothalamic expression of genes implicated in energy homeostasis, glucocorticoid function and methylation. Weight and adiposity were measured in adult littermates. Newborns of the restricted sows were lighter (P control newborns of both the sexes (P metabolic stress by nutrient insufficiency. A lower hypothalamic expression of anorexigenic peptides (LEPR and POMC, P controls (Pmetabolic alterations in the offspring. Differences in gene expression at birth and higher growth and adiposity in adulthood suggest a female-specific programming effect for a positive energy balance, possibly due to overexposure to endogenous stress-induced glucocorticoids.

Samish Indian Nation Long-Term Strategic Energy Plan

Energy Technology Data Exchange (ETDEWEB)

Christine Woodward; B. Beckley; K. Hagen

2005-06-30

The Tribes strategic energy planning effort is divided into three phases: (1) Completing an Energy Resource Assessment; (2) Developing a Long-Term Strategic Energy Plan; and (3) Preparing a Strategic Energy Implementation Plan for the Samish Homelands. The Samish Indian Nation developed a comprehensive Strategic Energy plan to set policy for future development on tribal land that consists of a long-term, integrated, systems approach to providing a framework under which the Samish Community can use resources efficiently, create energy-efficient infrastructures, and protect and enhance quality of life. Development of the Strategic Energy plan will help the Samish Nation create a healthy community that will sustain current and future generations by addressing economic, environmental, and social issues while respecting the Samish Indian Nation culture and traditions.

Short-Term Energy Outlook: Quarterly projections. Fourth quarter 1993

Energy Technology Data Exchange (ETDEWEB)

1993-11-05

The Energy Information Administration (EIA) prepares quarterly, short-term energy supply, demand, and price projections for publication in February, May, August, and November in the Short-Term Energy Outlook (Outlook). An annual supplement analyzes the performance of previous forecasts, compares recent cases with those of other forecasting services, and discusses current topics related to the short-term energy markets. (See Short-Term Energy Outlook Annual Supplement, DOE/EIA-0202.) The forecast period for this issue of the Outlook extends from the fourth quarter of 1993 through the fourth quarter of 1994. Values for the third quarter of 1993, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in the Weekly Petroleum Status Report) or are calculated from model simulations using the latest exogenous information available (for example, electricity sales and generation are simulated using actual weather data). The historical energy data are EIA data published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications.

Short-Term Caloric Restriction Suppresses Cardiac Oxidative Stress and Hypertrophy Caused by Chronic Pressure Overload.

Science.gov (United States)

Kobara, Miyuki; Furumori-Yukiya, Akiko; Kitamura, Miho; Matsumura, Mihoko; Ohigashi, Makoto; Toba, Hiroe; Nakata, Tetsuo

2015-08-01

Caloric restriction (CR) prevents senescent changes, in which reactive oxygen species (ROS) have a critical role. Left ventricular (LV) hypertrophy is a risk factor for cardiovascular diseases. We examined whether CR alters cardiac redox state and hypertrophy from chronic pressure overload. Male c57BL6 mice were subjected to ascending aortic constriction (AAC) with ad libitum caloric intake (AL + AAC group) or 40% restricted caloric intake (CR + AAC group). CR was initiated 2 weeks before AAC and was continued for 4 weeks. Two weeks after constriction, AAC increased LV wall thickness, impaired transmitral flow velocity, and augmented myocyte hypertrophy and fibrosis, in association with enhancement of BNP and collagen III expressions in the AL + AAC group. In the AL + AAC group, oxidative stress in cardiac tissue and mitochondria were enhanced, and NADPH oxidase activity and mitochondrial ROS production were elevated. These changes were significantly attenuated in the CR + AAC group. Additionally, in antioxidant systems, myocardial glutathione peroxidase and superoxide dismutase activities were enhanced in the CR + AAC group. Chronic pressure overload increased cardiac oxidative damage, in association with cardiac hypertrophy and fibrosis. Short-term CR suppressed oxidative stress and improved cardiac function, suggesting that short-term CR could be a useful strategy to prevent pressure overload-induced cardiac injury. Copyright © 2015 Elsevier Inc. All rights reserved.

Maternal HY-restricting HLA class II alleles are associated with poor long-term outcome in recurrent pregnancy loss after a boy.

Science.gov (United States)

Kolte, Astrid Marie; Steffensen, Rudi; Christiansen, Ole Bjarne; Nielsen, Henriette Svarre

2016-11-01

Women with secondary recurrent pregnancy loss (RPL) after a boy have a reduced chance of live birth in the first pregnancy after referral if they carry HY-restricting HLA class II alleles, but long-term chance of live birth is unknown. Live birth was compared for 540 women with unexplained secondary RPL according to firstborn's sex and maternal carriage of HLA-DRB3*03:01, HLA-DQB1*05:01/02, HLA-DRB1*15, and HLA-DRB1*07. The groups were compared by Cox proportional hazard ratios. For women with at firstborn boy, maternal carriage of HY-restricting HLA class II alleles decreased chance of live birth: 0 vs 1: hazard ratio 0.75 (95% CI 0.55-1.02); 0 vs 2: HR 0.62 (0.40-0.94). Carriage of HY-restricting HLA class II alleles decreased chance of live birth only if the firstborn was a boy: boy vs girl: HR 0.72 (95% CI 0.55-0.98). Maternal carriage of HY-restricting HLA class II alleles decreases long-term chance of live birth in women with RPL after a boy. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling.

Science.gov (United States)

Dong, Dan; Cai, Guang-Yan; Ning, Yi-Chun; Wang, Jing-Chao; Lv, Yang; Hong, Quan; Cui, Shao-Yuan; Fu, Bo; Guo, Ya-Nan; Chen, Xiang-Mei

2017-03-07

Renal fibrosis contributes to declining renal function in the elderly. What is unclear however, is whether epithelial-mesenchymal transition (EMT) contributes to this age-related renal fibrosis. Here, we analyzed indicators of EMT during kidney aging and investigated the protective effects and mechanisms of short-term regimens of caloric restriction (CR) or caloric restriction mimetics (CRMs), including resveratrol and metformin. High glucose was used to induce premature senescence and EMT in human primary proximal tubular cells (PTCs) in vitro. To test the role of AMPK-mTOR signaling, siRNA was used to deplete AMPK. Cellular senescence and AMPK-mTOR signaling markers associated with EMT were detected. CR or CRMs treatment alleviated age-related EMT in aging kidneys, which was accompanied by activation of AMPK-mTOR signaling. High glucose induced premature senescence and EMT in PTCs in vitro, which was accompanied by down-regulation of AMPK/mTOR signaling. CRMs alleviated high glucose-induced senescence and EMT via stimulation of AMPK/mTOR signaling. Activation of AMPK/mTOR signaling protected PTCs from high glucose-induced EMT and cellular senescence. Short-term regimens of CR and CRMs alleviated age-related EMT via AMPK-mTOR signaling, suggesting a potential approach to reducing renal fibrosis during aging.

Short-term energy outlook, July 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-07-01

The Energy Information Administration (EIA) prepares The Short-Term Energy Outlook (energy supply, demand, and price projections) monthly for distribution on the internet at: www.eia.doe.gov/emeu/steo/pub/contents.html. In addition, printed versions of the report are available to subscribers in January, April, July and October. The forecast period for this issue of the Outlook extends from July 1998 through December 1999. Values for second quarter of 1998 data, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in EIA`s Weekly Petroleum Status Report) or are calculated from model simulations that use the latest exogenous information available (for example, electricity sales and generation are simulated by using actual weather data). The historical energy data, compiled in the July 1998 version of the Short-Term Integrated Forecasting System (STIFS) database, are mostly EIA data regularly published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding. 28 figs., 19 tabs.

Glossary of scientific and technical terms in atomic energy

International Nuclear Information System (INIS)

1986-01-01

In order to facilitate the task of Arabic speaking scientists in the field of nuclear energy, the Atomic Energy Commission of Syria assigned a committee constituted of leading physicists and chemists at Damascus University, the aim of the commission was to include the Arabic equivalent of the terms cited in English, French, Russian and Spanish in the glossary published by the United Nations, 1958 ''Atomic Energy Glossary of Technical Terms.'' The result of the committee's work was this glossary containing approximately 6000 terms in the field of nuclear energy which are given in Arabic, English, French, Russian and Spanish

Superimposition of postnatal calorie restriction protects the aging male intrauterine growth- restricted offspring from metabolic maladaptations.

Science.gov (United States)

Dai, Yun; Thamotharan, Shanthie; Garg, Meena; Shin, Bo-Chul; Devaskar, Sherin U

2012-09-01

Intrauterine growth restriction (IUGR) results in dysregulated glucose homeostasis and adiposity in the adult. We hypothesized that with aging, these perturbations will wane, and superimposition of postnatal growth restriction (PNGR) on IUGR [intrauterine and postnatal growth restriction (IPGR)] will reverse the residual IUGR phenotype. We therefore undertook hyperinsulinemic-euglycemic clamp, energy balance, and physical activity studies during fed, fasted, and refed states, in light and dark cycles, on postweaned chow diet-fed more than 17-month aging male IUGR, PNGR, and IPGR vs. control (CON) rat offspring. Hyperinsulinemic-euglycemic clamp revealed similar whole-body insulin sensitivity and physical activity in the nonobese IUGR vs. CON, despite reduced heat production and energy expenditure. Compared with CON and IUGR, IPGR mimicking PNGR was lean and growth restricted with increased physical activity, O(2) consumption (VO(2)), energy intake, and expenditure. Although insulin sensitivity was no different in IPGR and PNGR, skeletal muscle insulin-induced glucose uptake was enhanced. This presentation proved protective against the chronologically earlier (5.5 months) development of obesity and dysregulated energy homeostasis after 19 wk on a postweaned high-fat diet. This protective role of PNGR on the metabolic IUGR phenotype needs future fine tuning aimed at minimizing unintended consequences.

Increased restrictive feeding practices are associated with reduced energy density in 4-6-year-old, multi-ethnic children at ad libitum laboratory test-meals.

Science.gov (United States)

Sud, Shama; Tamayo, Nina Carmela; Faith, Myles S; Keller, Kathleen L

2010-10-01

Increased reports of restrictive feeding have shown positive relationships to child obesity, however, the mechanism between the two has not been elucidated. This study examined the relationship between reported use of restrictive feeding practices and 4-6-year-old children's self-selected energy density (ED) and total energy intake from an ad libitum, laboratory dinner including macaroni and cheese, string beans, grapes, baby carrots, cheese sticks, pudding, milks, and a variety of sweetened beverages. A second objective explored the relationship between ED and child body mass index (BMI) z-score. Seventy (n=70) healthy children from primarily non-Caucasian and lower socioeconomic status families participated. Mothers completed the Child Feeding Questionnaire (CFQ) to assess restrictive feeding practices. Energy density (kcal/g) values for both foods and drinks (ED(food+drink)) and ED for foods only (ED(foods)) were calculated by dividing the average number of calories consumed by the average weight eaten across 4 meals. Higher maternal restriction was associated with lower ED(food+drink). In overweight and obese children only, higher maternal restriction was associated with lower ED(food). There was a non-significant trend for both ED measures to be negatively associated with child BMI z-score. Overall, restrictive feeding practices were not associated with child BMI z-score. However, when analyzing separate aspects of restriction, parents reported higher use of restricting access to palatable foods but lower use of using palatable foods as rewards with heavier children. Previous reports of positive associations between child obesity and restrictive feeding practices may not apply in predominantly non-Caucasian, lower socioeconomic status cohorts of children.

SirT1 regulates energy metabolism and response to caloric restriction in mice.

Directory of Open Access Journals (Sweden)

Gino Boily

Full Text Available The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.

WTO law and economics and restrictive practices in energy trade : The case of the OPEC cartel

NARCIS (Netherlands)

Marhold, Anna

2016-01-01

The World Trade Organization cannot deal comprehensively with restrictive export practices maintained by energy cartels such as the OPEC. The main reason for this is the absence of competition rules in the multilateral trading system. However, in spite of the fact that the WTO does not have rules on

Deep Restricted Kernel Machines Using Conjugate Feature Duality.

Science.gov (United States)

Suykens, Johan A K

2017-08-01

The aim of this letter is to propose a theory of deep restricted kernel machines offering new foundations for deep learning with kernel machines. From the viewpoint of deep learning, it is partially related to restricted Boltzmann machines, which are characterized by visible and hidden units in a bipartite graph without hidden-to-hidden connections and deep learning extensions as deep belief networks and deep Boltzmann machines. From the viewpoint of kernel machines, it includes least squares support vector machines for classification and regression, kernel principal component analysis (PCA), matrix singular value decomposition, and Parzen-type models. A key element is to first characterize these kernel machines in terms of so-called conjugate feature duality, yielding a representation with visible and hidden units. It is shown how this is related to the energy form in restricted Boltzmann machines, with continuous variables in a nonprobabilistic setting. In this new framework of so-called restricted kernel machine (RKM) representations, the dual variables correspond to hidden features. Deep RKM are obtained by coupling the RKMs. The method is illustrated for deep RKM, consisting of three levels with a least squares support vector machine regression level and two kernel PCA levels. In its primal form also deep feedforward neural networks can be trained within this framework.

Long term plan of atomic energy development and utilization

International Nuclear Information System (INIS)

1982-01-01

The atomic energy utilization and development in Japan have progressed remarkably, and already nuclear power generation has borne an important part in electric power supply, while radiation has been utilized in the fields of industry, agriculture, medicine and so on. Now, atomic energy is indispensable for national life and industrial activity. The former long term plan was decided in September, 1978, and the new long term plan should be established since the situation has changed largely. The energy substituting for petroleum has been demanded, and the expectation to nuclear power generation has heightened because it enables stable and economical power supply. The independently developed technology related to atomic energy must be put in practical use. The peaceful utilization of atomic energy must be promoted, while contributing to the nuclear non-proliferation policy. The Atomic Energy Commission of Japan decided the new long term plan to clearly show the outline of the important measures related to atomic energy development and utilization in 10 years hereafter, and the method of its promotion. The basic concept of atomic energy development and utilization, the long term prospect and the concept on the promotion, the method of promoting the development and utilization, and the problems of funds, engineers and location are described. (kako, I.)

Short-term energy outlook: Quarterly projections, Third quarter 1992

International Nuclear Information System (INIS)

1992-08-01

The Energy Information Administration (EIA) prepares quarterly, short-term energy supply, demand, and price projections for publication in February, May, August, and November in the Short-Term Energy Outlook (Outlook). An annual supplement analyzes the performance of previous forecasts, compares recent cases with those of other forecasting services, and discusses current topics related to the short-term energy markets. (See Short-Term Energy Outlook Annual Supplement, DOE/EIA-0202.) The principal users of the Outlook are managers and energy analysts in private industry and government. The forecast period for this issue of the Outlook extends from the third quarter of 1992 through the fourth quarter of 1993. Values for the second quarter of 1992, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in the Weekly Petroleum Status Report) or are calculated from model simulations using the latest exogenous information available (for example, electricity sales and generation are simulated using actual weather data). The historical energy data are EIA data published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding

Nutrition modulation of human aging: The calorie restriction paradigm.

Science.gov (United States)

Das, Sai Krupa; Balasubramanian, Priya; Weerasekara, Yasoma K

2017-11-05

Globally, the aging population is growing rapidly, creating an urgent need to attenuate age-related health conditions, including metabolic disease and disability. A promising strategy for healthy aging based on consistently positive results from studies with a variety of species, including non-human primates (NHP), is calorie restriction (CR), or the restriction of energy intake while maintaining intake of essential nutrients. The burgeoning evidence for this approach in humans is reviewed and the major study to date to address this question, CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy), is described. CALERIE findings indicate the feasibility of CR in non-obese humans, confirm observations in NHP, and are consistent with improvements in disease risk reduction and potential anti-aging effects. Finally, the mechanisms of CR in humans are reviewed which sums up the fact that evolutionarily conserved mechanisms mediate the anti-aging effects of CR. Overall, the prospect for further research in both NHP and humans is highly encouraging. Copyright © 2017 Elsevier B.V. All rights reserved.

Effects of maternal protein or energy restriction during late gestation on immune status and responses to lipopolysaccharide challenge in postnatal young goats.

Science.gov (United States)

He, Z X; Sun, Z H; Yang, W Z; Beauchemin, K A; Tang, S X; Zhou, C S; Han, X F; Wang, M; Kang, J H; Tan, Z L

2014-11-01

Knowledge of maternal malnutrition of ruminants and effects on development of the immune system of their offspring is lacking. A study was conducted to investigate the effects of maternal protein or energy restriction during late gestation on immune status of their offspring at different ages. Sixty-three pregnant goats (local breed, Liuyang black goat, 22.2 ± 1.5 kg at d 90 of gestation) were fed control (CON, ME = 9.34 MJ/kg and CP = 12.5%, DM basis), 40% protein restricted (PR), or 40% energy restricted (ER) diets from d 91 of gestation to parturition, after which all animals received an adequate diet for nutritional recovery. Plasma concentrations of complement components (C3, C4), C-reactive protein (CRP) and immunoglobulins (IgG and IgM), jejunum cytokines (IL-2, IL-6, and IL-10) expression levels and morphology in the offspring were measured. Additionally, plasma concentration of complement and IL-6, and cytokines expression levels in gastrointestinal tract obtained at 6 wk from young goats were assessed under saline or lipopolysaccharide (LPS) challenging conditions. Maternal PR or ER decreased (P 0.05) plasma CRP concentration. The IL-10 mRNA expression of jejunum from PR kids was also less (P 0.05) in any plasma or tissue immune parameters among the 3 treatments. However, when given a LPS challenge, ER and PR kids had greater (P = 0.02) IL-6 concentration compared with CON kids. Our results suggest that both PR and ER during late gestation induced short-term as well as long-lasting alterations on immune responses in their offspring, which may make the animals more susceptible to a bacterial pathogen challenge. The present findings expand the existing knowledge in immunological mechanisms responsible for the development of disease in later life.

Short-term preoperative calorie and protein restriction is feasible in healthy kidney donors and morbidly obese patients scheduled for surgery

NARCIS (Netherlands)

F. Jongbloed (Franny); R.W.F. de Bruin (Ron); R.A. Klaassen (René); P. Beekhof (Piet); H. van Steeg (Harry); F.J.M.F. Dor (Frank); E. van der Harst (Erwin); M.E.T. Dollé (Martijn); J.N.M. IJzermans (Jan)

2016-01-01

textabstractIntroduction. Surgery-induced oxidative stress increases the risk of perioperative complications and delay in postoperative recovery. In mice, short-term preoperative dietary and protein restriction protect against oxidative stress. We investigated the feasibility of a calorie- and

Decreases in fasting leptin and insulin concentrations after acute energy restriction and subsequent compensation in food intake

NARCIS (Netherlands)

Mars, M.; Graaf, de C.; Groot, de C.P.G.M.; Kok, F.J.

2005-01-01

The decrease in leptin after energy restriction is a starvation signal to the brain. Several studies have found an association between this decrease and subjective appetite; however, no solid data are available on the acute decrease in fasting leptin concentration and subsequent caloric

Efficacy and safety of misoprostol, dinoprostone and Cook's balloon for labour induction in women with foetal growth restriction at term.

Science.gov (United States)

Duro-Gómez, Jorge; Garrido-Oyarzún, María Fernanda; Rodríguez-Marín, Ana Belén; de la Torre González, Antonio Jesús; Arjona-Berral, José Eduardo; Castelo-Branco, Camil

2017-10-01

To compare effectiveness and safety of dinoprostone, misoprostol and Cook's balloon as labour-inducing agents in women with intrauterine growth restriction (IUGR) at term. Retrospective cohort chart review of women diagnosed with foetal growth restriction at term in Reina Sofia Hospital, Cordoba, Spain from January 2014 to December 2015. Registration of baseline characteristics and method of induction was made. The main outcome was time from induction to delivery. Obstetric and perinatal outcomes were also collected. A total of 99 women were diagnosed with IUGR in the mentioned period. Of them, 21 women were induced with dinoprostone [dinoprostone group (DG)], 20 with misoprostol (MG) and in 58 with Cook's balloon (CG). Groups were homogeneous regarding pre-induction Bishop score and parity. The CG required more time (24.36 vs. 19.23 h; p = 0.02) and more oxytocin dose for conduction of labour from induction to delivery (6.75 vs. 1.24 mUI; p women with IUGR at term, with a similar safety profile.

Effects of dietary fat energy restriction and fish oil feeding on hepatic metabolic abnormalities and insulin resistance in KK mice with high-fat diet-induced obesity.

Science.gov (United States)

Arai, Takeshi; Kim, Hyoun-ju; Hirako, Satoshi; Nakasatomi, Maki; Chiba, Hiroshige; Matsumoto, Akiyo

2013-01-01

We investigated the effects of dietary fat energy restriction and fish oil intake on glucose and lipid metabolism in female KK mice with high-fat (HF) diet-induced obesity. Mice were fed a lard/safflower oil (LSO50) diet consisting of 50 energy% (en%) lard/safflower oil as the fat source for 12 weeks. Then, the mice were fed various fat energy restriction (25 en% fat) diets - LSO, FO2.5, FO12.5 or FO25 - containing 0, 2.5, 12.5, or 25 en% fish oil, respectively, for 9 weeks. Conversion from a HF diet to each fat energy restriction diet significantly decreased final body weights and visceral and subcutaneous fat mass in all fat energy restriction groups, regardless of fish oil contents. Hepatic triglyceride and cholesterol levels markedly decreased in the FO12.5 and FO25 groups, but not in the LSO group. Although plasma insulin levels did not differ among groups, the blood glucose areas under the curve in the oral glucose tolerance test were significantly lower in the FO12.5 and FO25 groups. Real-time polymerase chain reaction analysis showed fatty acid synthase mRNA levels significantly decreased in the FO25 group, and stearoyl-CoA desaturase 1 mRNA levels markedly decreased in the FO12.5 and FO25 groups. These results demonstrate that body weight gains were suppressed by dietary fat energy restriction even in KK mice with HF diet-induced obesity. We also suggested that the combination of fat energy restriction and fish oil feeding decreased fat droplets and ameliorated hepatic hypertrophy and insulin resistance with suppression of de novo lipogenesis in these mice. Copyright © 2013 Elsevier Inc. All rights reserved.

Identification of differentially expressed genes induced by energy restriction using annealing control primer system from the liver and adipose tissues of broilers.

Science.gov (United States)

Wang, J W; Chen, W; Kang, X T; Huang, Y Q; Tian, Y D; Wang, Y B

2012-04-01

Female Arbor Acre broilers were divided into 2 groups at 18 d of age. One group of chickens had free access to feed (AL), and the other group of chickens had 30% energy restriction (ER). Adipose and hepatic RNA samples were collected at 48 d of age. We employed an accurate reverse-transcription (RT) PCR method that involves annealing control primers to identify the differentially expressed genes (DEG) between ER and AL groups. Using 20 annealing control primers, 43 differentially expressed bands (40 downregulated and 3 upregulated in the ER group) were detected from the hepatic tissue, whereas no differentially expressed bands were detected from the adipose tissue. It seems that energy restriction could induce more DEG in hepatic tissue than that in adipose tissue and could result in more gene-expression downregulation in hepatic tissue. Eight DEG (6 known and 2 unknown genes) were gained from hepatic tissue and confirmed by RT-PCR, which were all supported by released expressed sequence tag sequences. Their expressions were all downregulated by energy restriction in hepatic tissues. Six known genes are RPL7, RPLP1, FBXL12, ND1, ANTXR2, and SLC22A18, respectively, which seem to play essential roles in the protein translation, energy metabolism, and tumor inhibition. The alterations of gene expression in 3 selected genes, including ND1 (P < 0.01), FBXL12 (P < 0.01), and RPLP1 (P < 0.05), were supported by real-time quantitative RT-PCR reaction. Our data provide new insights on the metabolic state of broilers changed by energy restriction.

Non-Abelian S-term dark energy and inflation

Science.gov (United States)

Rodríguez, Yeinzon; Navarro, Andrés A.

2018-03-01

We study the role that a cosmic triad in the generalized SU(2) Proca theory, specifically in one of the pieces of the Lagrangian that involves the symmetric version Sμν of the gauge field strength tensor Fμν, has on dark energy and primordial inflation. Regarding dark energy, the triad behaves asymptotically as a couple of radiation perfect fluids whose energy densities are negative for the S term but positive for the Yang-Mills term. This leads to an interesting dynamical fine-tuning mechanism that gives rise to a combined equation of state parameter ω ≃ - 1 and, therefore, to an eternal period of accelerated isotropic expansion for an ample spectrum of initial conditions. Regarding primordial inflation, one of the critical points of the associated dynamical system can describe a prolonged period of isotropic slow-roll inflation sustained by the S term. This period ends up when the Yang-Mills term dominates the energy density leading to the radiation dominated epoch. Unfortunately, in contrast to the dark energy case, the primordial inflation scenario is strongly sensitive to the coupling constants and initial conditions. The whole model, including the other pieces of the Lagrangian that involve Sμν, might evade the recent strong constraints coming from the gravitational wave signal GW170817 and its electromagnetic counterpart GRB 170817A.

Short-term energy outlook, January 1999

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-01-01

The Energy Information Administration (EIA) prepares the Short-Term Energy Outlook (energy supply, demand, and price projections) monthly. The forecast period for this issue of the Outlook extends from January 1999 through December 2000. Data values for the fourth quarter 1998, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in EIA`s Weekly Petroleum Status Report) or are calculated from model simulations that use the latest exogenous information available (for example, electricity sales and generation are simulated by using actual weather data). The historical energy data, compiled in the January 1999 version of the Short-Term Integrated Forecasting System (STIFS) database, are mostly EIA data regularly published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding. The STIFS model is driven principally by three sets of assumptions or inputs: estimates of key macroeconomic variables, world oil price assumptions, and assumptions about the severity of weather. Macroeconomic estimates are produced by DRI/McGraw-Hill but are adjusted by EIA to reflect EIA assumptions about the world price of crude oil, energy product prices, and other assumptions which may affect the macroeconomic outlook. By varying the assumptions, alternative cases are produced by using the STIFS model. 28 figs., 19 tabs.

Protective effects of short-term dietary restriction in surgical stress and chemotherapy.

Science.gov (United States)

Brandhorst, Sebastian; Harputlugil, Eylul; Mitchell, James R; Longo, Valter D

2017-10-01

Reduced caloric intake including fasting, as well as the dietary composition or the timing of food intake, impact longevity, likely through a modification in the onset or the severity of chronic aging-related diseases such as cancer. As with pre- and post-operative dietary recommendations, evidence-based nutritional advice from healthcare professionals during and after cancer treatment is often vague or conflicting. We hypothesize that preventive dietary recommendations can help in the context of both chronic cancer treatment efficacy and the avoidance of development of secondary malignancies, as well as in the context of protection from the acute stress of surgery. In this perspective review, we will discuss the latest findings on the potential role of short-term dietary restriction in cancer treatment and improvement of surgical outcome. Copyright © 2017. Published by Elsevier B.V.

Reversibility of β-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse

Directory of Open Access Journals (Sweden)

Chunjun Sheng

2016-01-01

Full Text Available Type 2 diabetes (T2D is characterized by β-cell dedifferentiation, but underlying mechanisms remain unclear. The purpose of the current study was to explore the mechanisms of β-cell dedifferentiation with and without long-term control of calorie intake. We used a diabetes mouse model (db/db to analyze the changes in the expression levels of β-cell-specific transcription factors (TFs and functional factors with long-term caloric restriction (CR. Our results showed that chronic euglycemia was maintained in the db/db mice with long-term CR intervention, and β-cell dedifferentiation was significantly reduced. The expression of Glut2, Pdx1, and Nkx6.1 was reversed, while MafA expression was significantly increased with long-term CR. GLP-1 pathway was reactivated with long-term CR. Our work showed that the course of β-cell dedifferentiation can intervene by long-term control of calorie intake. Key β-cell-specific TFs and functional factors play important roles in maintaining β-cell differentiation. Targeting these factors could optimize T2D therapies.

Long-term alternative energy R and D strategies

International Nuclear Information System (INIS)

1981-01-01

Within the coming decades a transition must be initiated from oil and gas to 'unlimited' primary energy sources, i.e., nuclear and solar energy. Ever more expensive fossil energy forms will have to provide for an intermediary solution to the growing global energy demand. While a rather clear-cut picture of the energy problem has emerged on the global level, a straightforward translation to the national or even to the company level is not available. The current study contract between the European Economic Community and the International Institute for Applied Systems Analysis (IIASA) is a first exercice designed to transfer the global results to the intermediary level of the ''Subregion'' of the European Community. In operational terms the contract aims at identifying long-term (up to 2030) alternative energy R and D strategies for twelve European countries that would be consistent with the global scenarios, identified by IIASA

Long-term energy futures: the critical role of technology

International Nuclear Information System (INIS)

Grubler, A.

1999-01-01

The paper briefly reviews the results of a 5-year study conducted by IIASA jointly with the World Energy Council (WEC) on long term-energy perspectives. After summarizing the study's main findings, the paper addresses the crucial role of technological change in the evolution of long-term energy futures and in responding to key long-term uncertainties in the domains of energy demand growth, economics, as well as environmental protection. Based on most recent empirical and methodological findings, long-term dynamics of technological change portray a number of distinct features that need to be taken account of in technology and energy policy. First, success of innovation efforts and ultimate outcomes of technological are uncertain. Second, new, improved technologies are not a free good, but require continued dedicated efforts. Third, technological knowledge (as resulting from R and D and accumulation of experience, i.e. technological learning) exhibits characteristics of (uncertain) increasing returns. Forth, due to innovation - diffusion lags, technological interdependence, and infrastructure needs (network externalities), rates of change in large-scale energy systems are necessarily slow. This implies acting sooner rather than later as a contigency policy to respond to long-term social, economic and environmental uncertainties, most notably possible climate change. Rather than picking technological 'winners' the results of the IIASA-WEC scenario studies are seen most appropriate to guide technology and R and D portfolio analysis. Nonetheless, robust persistent patterns of technological change invariably occur across all scenarios. Examples of primising groups of technologies are given. The crucial importance of meeting long-energy demand in developing countries, assuring large-scale infrastructure investments, maintaining a strong and diversified R AND D protfolio, as well as to dvise new institutional mechnisms for technology development and diffusion for instance

Low energy restrictions for a flipped left-right symmetric model

Energy Technology Data Exchange (ETDEWEB)

Eeg, J.O. (Oslo Univ. (Norway). Fysisk Inst.)

1990-05-01

I consider some low energy restrictions for a 'flipped' left-right symmetric model containing exotic fermions of E{sub 6} and a right-handed W-boson, all with odd R-parity. The new interactions due to W{sub R}-exchange have no significant impact on rare kaon decays, because the W{sub R} does not couple to d, s, b quarks. On the other hand, W{sub R} exchanges might induce rare processes like D-anti D mixing, D{sup 0}{yields}{mu}anti {mu}, D{sup 0}{yields}{mu}anti e, {mu}{yields}e{gamma}, {mu}{yields}3e, and {mu}N{yields}eN. It turns out that the strongest bound is obtained from D-anti D mixing. With reasonable extra assumptions, it is found that the exotic right-handed W-boson is likely to be heavier than 500 to 1500 GeV. (orig.).

A randomized trial of energy-restricted high-protein versus high-carbohydrate, low-fat diet in morbid obesity.

Science.gov (United States)

Dalle Grave, Riccardo; Calugi, Simona; Gavasso, Ilaria; El Ghoch, Marwan; Marchesini, Giulio

2013-09-01

Conflicting evidence exists as to weight loss produced by diets with different carbohydrate/protein ratio. The aim was to compare the long-term effects of high-protein vs. high-carbohydrate diet (HPD, HCD), combined with cognitive behavior therapy (CBT). In a randomized trial, 88 obese participants (mean age, 46.7; mean BMI, 45.6 kg m(-2) ) were enrolled in a 3-week inpatient and 48-week outpatient treatment, with continuous CBT during the study period. All subjects consumed a restricted diet (1,200 kcal day(-1) for women, 1,500 for men; 20% energy from fat, fat). HPD derived 34% energy from proteins, 46% from carbohydrates; HCD 17% from proteins, 64% from carbohydrates. The primary outcome was 1-year percent weight loss. Secondary outcomes were attrition rates and changes in cardiovascular risk factors and psychological profile. Attrition rates were similar between groups (25.6%). In the intention-to-treat analysis, weight loss averaged 15.0% in HPD and 13.3% in HCD at 1 year, without any difference throughout the study period. Both diets produced a similar improvement in secondary outcomes. The relative carbohydrate and protein content of the diet, when combined with intensive CBT, does not significantly affect attrition rate, weight loss and psychosocial outcome in patients with severe obesity. Copyright © 2013 The Obesity Society.

Aerobic Exercise Attenuates the Loss of Skeletal Muscle during Energy Restriction in Adults with Visceral Adiposity

Directory of Open Access Journals (Sweden)

Eiichi Yoshimura

2014-01-01

Full Text Available Objective: To evaluate the effects of energy restriction with or without aerobic exercise on thigh muscle mass and quality in adults with visceral adiposity. Methods: 75 males and females were randomly assigned to the groups ‘diet only' (DO; n = 42 or ‘diet plus aerobic exercise' (D/Ex; n = 33 for 12 weeks. The target energy intake in both groups was 25 kcal/kg of ideal body weight. Subjects in the D/Ex group were instructed to exercise for ≥300 min/week at lactate threshold. Computed tomography was used to measure thigh muscle cross-sectional area (CSA, normal-density muscle area (NDMA, and visceral fat area. Results: Total body weight (DO: -6.6 ± 3.6%; D/Ex: -7.3 ± 4.6% and visceral fat (DO: -16.0 ± 13.8%; D/Ex: -23.1 ± 14.7% decreased significantly in both groups; however, the changes were not significantly different between the two groups. The decrease in muscle CSA was significantly greater in the DO group (-5.1 ± 4.5% compared with the D/Ex group (-2.5 ± 5.0%. NDMA decreased significantly in the DO (-4.9 ± 4.9% but not in the D/Ex group (-1.4 ± 5.0%. Conclusion: Aerobic exercise attenuated the loss of skeletal muscle during energy restriction in adults with visceral adiposity.

Aerobic Exercise Attenuates the Loss of Skeletal Muscle during Energy Restriction in Adults with Visceral Adiposity

Science.gov (United States)

Yoshimura, Eiichi; Kumahara, Hideaki; Tobina, Takuro; Matsuda, Takuro; Watabe, Kiwa; Matono, Sakiko; Ayabe, Makoto; Kiyonaga, Akira; Anzai, Keizo; Higaki, Yasuki; Tanaka, Hiroaki

2014-01-01

Objective To evaluate the effects of energy restriction with or without aerobic exercise on thigh muscle mass and quality in adults with visceral adiposity. Methods 75 males and females were randomly assigned to the groups ‘diet only’ (DO; n = 42) or ‘diet plus aerobic exercise’ (D/Ex; n = 33) for 12 weeks. The target energy intake in both groups was 25 kcal/kg of ideal body weight. Subjects in the D/Ex group were instructed to exercise for ≥300 min/week at lactate threshold. Computed tomography was used to measure thigh muscle cross-sectional area (CSA), normal-density muscle area (NDMA), and visceral fat area. Results Total body weight (DO: −6.6 ± 3.6%; D/Ex: −7.3 ± 4.6%) and visceral fat (DO: −16.0 ± 13.8%; D/Ex: −23.1 ± 14.7%) decreased significantly in both groups; however, the changes were not significantly different between the two groups. The decrease in muscle CSA was significantly greater in the DO group (-5.1 ± 4.5%) compared with the D/Ex group (-2.5 ± 5.0%). NDMA decreased significantly in the DO (-4.9 ± 4.9%) but not in the D/Ex group (-1.4 ± 5.0%). Conclusion Aerobic exercise attenuated the loss of skeletal muscle during energy restriction in adults with visceral adiposity. PMID:24457527

The IEA Model of Short-term Energy Security

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

Ensuring energy security has been at the centre of the IEA mission since its inception, following the oil crises of the early 1970s. While the security of oil supplies remains important, contemporary energy security policies must address all energy sources and cover a comprehensive range of natural, economic and political risks that affect energy sources, infrastructures and services. In response to this challenge, the IEA is currently developing a Model Of Short-term Energy Security (MOSES) to evaluate the energy security risks and resilience capacities of its member countries. The current version of MOSES covers short-term security of supply for primary energy sources and secondary fuels among IEA countries. It also lays the foundation for analysis of vulnerabilities of electricity and end-use energy sectors. MOSES contains a novel approach to analysing energy security, which can be used to identify energy security priorities, as a starting point for national energy security assessments and to track the evolution of a country's energy security profile. By grouping together countries with similar 'energy security profiles', MOSES depicts the energy security landscape of IEA countries. By extending the MOSES methodology to electricity security and energy services in the future, the IEA aims to develop a comprehensive policy-relevant perspective on global energy security. This Working Paper is intended for readers who wish to explore the MOSES methodology in depth; there is also a brochure which provides an overview of the analysis and results.

Long-term strategies in world energy supply

International Nuclear Information System (INIS)

Haefele, W.

1980-01-01

The International Institute for Applied Systems Analysis of Laxenburg, Austria has carried out a comprehensive systems analysis in which the problems of the long-term world energy supply are treated first qualitatively and then quantiatively. The results of this five-year study have been published in a book entitled 'Energy in a Finite World: a Global Energy Systems Analysis.' This summary of the book indicates that the world's energy supply in the next fifty years will not be limited by resources, but the rates at which new technologies will be built up. (orig.) [de

The long-term relationships among China's energy consumption sources and adjustments to its renewable energy policy

International Nuclear Information System (INIS)

Zou Gaolu

2012-01-01

To reduce its consumption of coal and oil in its primary energy consumption, China promotes the development of renewable energy resources. I have analysed the long-term relationship among China's primary energy consumption sources. Changes in coal consumption lead those in the consumption of other energy sources in the long term. Coal and oil fuels substitute for each other equally. The long-term elasticities of China's coal consumption relative to its hydroelectricity consumption were greater than one and nearly equal during the two sample periods. Therefore, increased hydroelectricity consumption did not imply a reduction in coal consumption. China holds abundant hydroelectricity, wind and, solar energy potential. China must prevent an excessive escalation of its economy and resultant energy demand to realise a meaningful substitution of coal with hydroelectricity. Moreover, China must develop and use wind and solar energy sources. Natural gas can be a good substitute for coal, given its moderate price growth and affordable price levels. - Highlights: ► Coal consumption changes lead those of other energy sources in the long term. ► Coal and oil fuels substitute for each other equally. ► Increased hydroelectricity consumption has not meant lower coal consumption. ► Wind, solar and natural gas are China's promising energy sources.

Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet

Directory of Open Access Journals (Sweden)

Seyfried B

2009-09-01

Full Text Available Malignant brain tumors are a significant health problem in children and adults and are largely unmanageable. As a metabolic disorder involving the dysregulation of glycolysis and respiration (the Warburg effect, malignant brain cancer can be managed through changes in metabolic environment. In contrast to malignant brain tumors that are mostly dependent on glycolysis for energy, normal neurons and glia readily transition to ketone bodies (β-hydroxybutyrate for energy in vivo when glucose levels are reduced. The transition from glucose to ketone bodies as a major energy source is an evolutionary conserved adaptation to food deprivation that permits the survival of normal cells during extreme shifts in nutritional environment. Only those cells with a flexible genome, honed through millions of years of environmental forcing and variability selection, can transition from one energy state to another. We propose a different approach to brain cancer management that exploits the metabolic flexibility of normal cells at the expense of the genetically defective and less metabolically flexible tumor cells. This approach to brain cancer management is supported from recent studies in orthotopic mouse brain tumor models and in human pediatric astrocytoma treated with calorie restriction and the ketogenic diet. Issues of implementation and use protocols are discussed.

Long-term equilibrium effects of constraints in energy supply

International Nuclear Information System (INIS)

Brookes, L.G.

1984-01-01

The subject is covered in sections, entitled: introduction; the economic role of energy; the economics of energy price; a first attempt to model long term effects (energy consumption and economic activity); what is a price hike (energy supply and demand functions before and after price hike); modelling energy price hikes; implications and lessons for nuclear energy; the present reality. (U.K.)

Effective electrical energy policies in terms of DSM

Energy Technology Data Exchange (ETDEWEB)

Song, Hyunah

2010-09-15

This paper investigates how well energy policies are adopted and operated. In terms of DSM or the Demand Side Management, ways of modifying energy demand are introduced. Also their effects are showed. Furthermore future plans of DSM are illustrated shortly.

Short- and long-term effects of continuous versus intermittent restrictive diet approaches on body composition and the metabolic profile in overweight and obese postmenopausal women: a pilot study.

Science.gov (United States)

Arguin, Hélène; Dionne, Isabelle J; Sénéchal, Martin; Bouchard, Danielle R; Carpentier, André C; Ardilouze, Jean-Luc; Tremblay, Angelo; Leblanc, Claude; Brochu, Martin

2012-08-01

The objective of this study was to compare changes in body composition and the metabolic profile between women taking an intermittent diet (ID) and women taking a continuous diet (CD). Twenty-five obese postmenopausal women were randomized to an ID (n = 13) or a CD (n = 12). In the ID, 5-week energy restriction periods were followed by 5-week weight stabilization periods. In the CD, 15 weeks of energy restriction was followed by 5 weeks of weight stabilization. Outcome measures before, during, and after weight loss, as well as after a 1-year follow-up, were body weight and composition, waist circumference, resting metabolic rate, and fasting lipid and glucose levels. Body weight, waist circumference, percentage fat mass, and fat mass decreased significantly and similarly in both groups (P fasting glucose decreased significantly in the ID group only. High-density lipoprotein cholesterol and resting metabolic rate remained stable in both groups. Fasting plasma triglyceride and glucose levels were the only metabolic variables to further improve after the fifth week of the protocol. At the 1-year follow-up, both interventions were associated with successful and similar weight loss maintenance and improvements in fasting plasma glucose levels. The ID resulted in similar short- and long-term changes in body composition and metabolic profile compared with a CD. Most improvements occurred during the first 5 weeks of treatment in both interventions.

Effect of restricted pacifier use in breastfeeding term infants for increasing duration of breastfeeding.

Science.gov (United States)

Jaafar, Sharifah Halimah; Ho, Jacqueline J; Jahanfar, Shayesteh; Angolkar, Mubashir

2016-08-30

To successfully initiate and maintain breastfeeding for a longer duration, the World Health Organization's Ten Steps to Successful Breastfeeding recommends total avoidance of artificial teats or pacifiers for breastfeeding infants. Concerns have been raised that offering the pacifier instead of the breast to calm the infant may lead to less frequent episodes of breastfeeding and as a consequence may reduce breast-milk production and shorten duration of breastfeeding. To assess the effect of restricted versus unrestricted pacifier use in healthy full-term newborns whose mothers have initiated breastfeeding and intend to exclusively breastfeed, on the duration of breastfeeding, other breastfeeding outcomes and infant health. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 June 2016) and reference lists of retrieved studies. Randomised and quasi-randomised controlled trials comparing restricted versus unrestricted pacifier use in healthy full-term newborns who have initiated breastfeeding. Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. The quality of the evidence was assessed using the GRADE approach. We found three trials (involving 1915 babies) for inclusion in the review, but have included only two trials (involving 1302 healthy full-term breastfeeding infants) in the analysis. Meta-analysis of the two combined studies showed that pacifier use in healthy breastfeeding infants had no significant effect on the proportion of infants exclusively breastfed at three months (risk ratio (RR) 1.01; 95% confidence interval (CI) 0.96 to 1.07, two studies, 1228 infants), and at four months of age (RR 1.01; 95% CI 0.94 to 1.09, one study, 970 infants, moderate-quality evidence), and also had no effect on the proportion of infants partially breastfed at three months (RR 1.00; 95% CI 0.98 to 1.02, two studies, 1228 infants), and at four months of age (RR 0.99; 95% CI 0

Emergency building temperature restrictions. Final evaluation

Energy Technology Data Exchange (ETDEWEB)

None

1980-11-01

On July 5, 1979, DOE promulgated final regulations of the Emergency Building Temperature Restrictions program, placing emergency restrictions on thermostat settings for space heating, space cooling, and hot water in commercial, industrial, and nonresidential public buildings. The final regulations restricted space heating to a maximum of 65/sup 0/F, hot water temperature to a maximum of 105/sup 0/F, and cooling temperature to a minimum of 78/sup 0/F. A comprehensive evaluation of the entire EBTF program for a nine-month period from July 16, 1979 is presented. In Chapter 1, an estimate of the population of buildings covered by EBTR is presented. In Chapter 2, EBTR compliance by building type and region is reported. Exemptions are also discussed. In Chapter 3, the simulations of building energy use are explained and the relative impact of various building characteristics and effectiveness of different control strategies are estimated. Finally, in Chapter 4, the methodology for scaling the individual building energy savings to the national level is described, and estimated national energy savings are presented.

10 CFR 1016.34 - Accountability for Secret Restricted Data.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Accountability for Secret Restricted Data. 1016.34 Section... Information § 1016.34 Accountability for Secret Restricted Data. Each permittee possessing documents containing Secret Restricted Data shall establish a document accountability procedure and shall maintain...

DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil

Directory of Open Access Journals (Sweden)

Cátia Lira do Amaral

2014-01-01

Full Text Available Dietary factors modulate gene expression and are able to alter epigenetic signatures in peripheral blood mononuclear cells (PBMC. However, there are limited studies about the effects of omega-3 polyunsaturated fatty acids (n-3 PUFA on the epigenetic mechanisms that regulate gene expression. This research investigates the effects of n-3-rich fish oil supplementation on DNA methylation profile of several genes whose expression has been reported to be downregulated by n-3 PUFA in PBMC: CD36, FFAR3, CD14, PDK4, and FADS1. Young overweight women were supplemented with fish oil or control in a randomized 8-week intervention trial following a balanced diet with 30% energy restriction. Fatty acid receptor CD36 decreased DNA methylation at CpG +477 due to energy restriction. Hypocaloric diet-induced weight loss also reduced the methylation percentages of CpG sites located in CD14, PDK4, and FADS1. The methylation patterns of these genes were only slightly affected by the fish oil supplementation, being the most relevant to the attenuation of the weight loss-induced decrease in CD36 methylation after adjusting by baseline body weight. These results suggest that the n-3 PUFA-induced changes in the expression of these genes in PBMC are not mediated by DNA methylation, although other epigenetic mechanisms cannot be discarded.

Short-term energy outlook. Quarterly projections, first quarter 1995

International Nuclear Information System (INIS)

1995-02-01

The Energy Information Administration (EIA) prepares quarterly, short-term energy supply, demand, and price projections for publication in February, May, August, and November in the Short-Term Energy Outlook (Outlook). The forecast period for this issue of the Outlook extends from the first quarter of 1995 through the fourth quarter of 1996. Values for the fourth quarter of 1994, however, are preliminary EIA estimates or are calculated from model simulations using the latest exogenous information available (for example, electricity sales and generation are simulated using actual weather data). The historical energy data, compiled into the first quarter 1995 version of the Short-Term Integrated Forecasting System (STIFS) database, are mostly EIA data regularly published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding. The STIFS database is archived quarterly and is available from the National Technical Information Service. The cases are produced using the Short-Term Integrated Forecasting System (STIFS). The STIFS model is driven principally by three sets of assumptions or inputs: estimates of key macroeconomic variables, world oil price assumptions, and assumptions about the severity of weather. Macroeconomic estimates are produced by DRI/McGraw-Hill but are adjusted by EIA to reflect EIA assumptions about the world price of crude oil, energy product prices, and other assumptions which may affect the macroeconomic outlook. The EIA model is available on computer tape from the National Technical Information Service

10 CFR 1045.33 - Appointment of restricted data management official.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Appointment of restricted data management official. 1045... DECLASSIFICATION Generation and Review of Documents Containing Restricted Data and Formerly Restricted Data § 1045.33 Appointment of restricted data management official. (a) Each agency with access to RD or FRD shall...

Ukraine National Energy Current State and Modelling its Long-Term Development

International Nuclear Information System (INIS)

Shulzhenko, S.

2016-01-01

Structure of Ukrainian energy sector, its current challenges, drivers of its development and possible long-term pathways, and methodological approaches and methods of mathematical modelling of long-term national energy development.(author).

Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

NARCIS (Netherlands)

Timmers, Silvie; Konings, Ellen; Bilet, Lena; Houtkooper, Riekelt H.; Weijer, van de Tineke; Hoeks, Joris; Krieken, van der Sophie; Ryu, Dongryeol; Kersten, Sander; Moonen-Kornips, Esther; Goossens, Gijs H.; Hesselink, Matthijs K.; Kunz, Iris; Schrauwen-Hinderling, Vera B.; Blaak, Ellen E.; Auwerx, Johan; Schrauwen, Patrick

2011-01-01

Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized

Utility of circulating IGF-I as a biomarker for assessing body composition changes in men during periods of high physical activity superimposed upon energy and sleep restriction.

Science.gov (United States)

Nindl, Bradley C; Alemany, Joseph A; Kellogg, Mark D; Rood, Jennifer; Allison, Steven A; Young, Andrew J; Montain, Scott J

2007-07-01

Insulin-like growth factor (IGF)-I is a biomarker that may have greater utility than other conventional nutritional biomarkers in assessing nutritional, health, and fitness status. We hypothesized that the IGF-I system would directionally track a short-term energy deficit and would be more related to changes in body composition than other nutritional biomarkers. Thirty-five healthy men (24 +/- 0.3 yr) underwent 8 days of exercise and energy imbalance. Total and free IGF-I, IGF binding proteins-1, -2, and -3, the acid labile subunit, transferrin, ferritin, retinol binding protein, prealbumin, testosterone, triiodothyronine, thyroxine, and leptin responses were measured. Dual-energy X-ray absorptiometry assessed changes in body mass and composition. Repeated-measures ANOVA, correlation analysis, and receiver operator characteristic curves were used for statistical analyses (P losing >5% body mass. The IGF-I system is an important adjunct in the overall assessment of adaptation to stress imposed by high levels of physical activity superimposed on energy and sleep restriction and is more closely associated with losses in body mass and fat-free mass than other conventional nutritional biomarkers.

Potentials for energy savings and long term energy demand of Croatian households sector

International Nuclear Information System (INIS)

Pukšec, Tomislav; Vad Mathiesen, Brian; Duić, Neven

2013-01-01

Highlights: ► Long term energy demand of Croatian households sector has been modelled. ► Developed model can describe the whole households sector. ► Main modes include heating, cooling, electrical appliances, cooking and hot water. ► Different scenarios regarding future energy demand are presented and discussed. -- Abstract: Households represent one of the most interesting sectors, when analyzing Croatia’s energy balance. It makes up one of the largest energy consumers with around 75 PJ per year, which is almost 29% of Croatia’s final energy demand. Considering this consumption, implementing various mechanisms, which would lead to improvements in energy efficiency of this sector, seems relevant. In order to plan future energy systems, important would be to know future possibilities and needs regarding energy demand of different sectors. Through this paper, long term energy demand projections of Croatian households sector will be shown. Focus of the paper will be on various mechanisms influencing future energy demand scenarios. Important would be to quantify this influence, whether positive or negative, and see which mechanisms would be the most significant. Energy demand projections in this paper are based upon bottom-up approach model which combines and processes a large number of input data. The model will be compared to Croatian National Energy Strategy and certain differences and conclusions will be presented. One of the major conclusions shown in this paper is significant possibilities for energy efficiency improvements and lower energy demand in the future, based on careful and rational energy planning. Different financial, legal and technological mechanisms can lead to significant savings in the households sector which leads to lower GHG emissions and lower Croatian dependence on foreign fossil fuels.

Whey protein supplementation preserves postprandial myofibrillar protein synthesis during short-term energy restriction in overweight and obese adults.

Science.gov (United States)

Hector, Amy J; Marcotte, George R; Churchward-Venne, Tyler A; Murphy, Caoileann H; Breen, Leigh; von Allmen, Mark; Baker, Steven K; Phillips, Stuart M

2015-02-01

Higher dietary energy as protein during weight loss results in a greater loss of fat mass and retention of muscle mass; however, the impact of protein quality on the rates of myofibrillar protein synthesis (MPS) and lipolysis, processes that are important in the maintenance of muscle and loss of fat, respectively, are unknown. We aimed to determine how the consumption of different sources of proteins (soy or whey) during a controlled short-term (14-d) hypoenergetic diet affected MPS and lipolysis. Men (n = 19) and women (n = 21) (age 35-65 y; body mass index 28-50 kg/m(2)) completed a 14-d controlled hypoenergetic diet (-750 kcal/d). Participants were randomly assigned, double blind, to receive twice-daily supplements of isolated whey (27 g/supplement) or soy (26 g/supplement), providing a total protein intake of 1.3 ± 0.1 g/(kg · d), or isoenergetic carbohydrate (25 g maltodextrin/supplement) resulting in a total protein intake of 0.7 ± 0.1 g/(kg · d). Before and after the dietary intervention, primed continuous infusions of L-[ring-(13)C6] phenylalanine and [(2)H5]-glycerol were used to measure postabsorptive and postprandial rates of MPS and lipolysis. Preintervention, MPS was stimulated more (P whey than with soy or carbohydrate. Postintervention, postabsorptive MPS decreased similarly in all groups (all P whey group, which was less (P whey. We conclude that whey protein supplementation attenuated the decline in postprandial rates of MPS after weight loss, which may be of importance in the preservation of lean mass during longer-term weight loss interventions. This trial was registered at clinicaltrials.gov as NCT01530646. © 2015 American Society for Nutrition.

Protein-Pacing Caloric-Restriction Enhances Body Composition Similarly in Obese Men and Women during Weight Loss and Sustains Efficacy during Long-Term Weight Maintenance.

Science.gov (United States)

Arciero, Paul J; Edmonds, Rohan; He, Feng; Ward, Emery; Gumpricht, Eric; Mohr, Alex; Ormsbee, Michael J; Astrup, Arne

2016-07-30

Short-Term protein-pacing (P; ~6 meals/day, >30% protein/day) and caloric restriction (CR, ~25% energy deficit) improves total (TBF), abdominal (ABF) and visceral (VAT) fat loss, energy expenditure, and biomarkers compared to heart healthy (HH) recommendations (3 meals/day, 15% protein/day) in obese adults. Less is known whether obese men and women respond similarly to P-CR during weight loss (WL) and whether a modified P-CR (mP-CR) is more efficacious than a HH diet during long-term (52 week) weight maintenance (WM). The purposes of this study were to evaluate the efficacy of: (1) P-CR on TBF, ABF, resting metabolic rate (RMR), and biomarkers between obese men and women during WL (weeks 0-12); and (2) mP-CR compared to a HH diet during WM (weeks 13-64). During WL, men (n = 21) and women (n = 19) were assessed for TBF, ABF, VAT, RMR, and biomarkers at weeks 0 (pre) and 12 (post). Men and women had similar reductions (p 50%) and increase in % lean body mass (9%). RMR (kcals/kg bodyweight) was unchanged and respiratory quotient decreased 9%. Twenty-four subjects (mP-CR, n = 10; HH, n = 14) completed WM. mP-CR regained significantly less body weight (6%), TBF (12%), and ABF (17%) compared to HH (p < 0.05). Our results demonstrate P-CR enhances weight loss, body composition and biomarkers, and maintains these changes for 52-weeks compared to a traditional HH diet.

Greek long-term energy consumption prediction using artificial neural networks

International Nuclear Information System (INIS)

Ekonomou, L.

2010-01-01

In this paper artificial neural networks (ANN) are addressed in order the Greek long-term energy consumption to be predicted. The multilayer perceptron model (MLP) has been used for this purpose by testing several possible architectures in order to be selected the one with the best generalizing ability. Actual recorded input and output data that influence long-term energy consumption were used in the training, validation and testing process. The developed ANN model is used for the prediction of 2005-2008, 2010, 2012 and 2015 Greek energy consumption. The produced ANN results for years 2005-2008 were compared with the results produced by a linear regression method, a support vector machine method and with real energy consumption records showing a great accuracy. The proposed approach can be useful in the effective implementation of energy policies, since accurate predictions of energy consumption affect the capital investment, the environmental quality, the revenue analysis, the market research management, while conserve at the same time the supply security. Furthermore it constitutes an accurate tool for the Greek long-term energy consumption prediction problem, which up today has not been faced effectively.

How can we restrict the sale of sports and energy drinks to children? A proposal for a World Health Organization-sponsored framework convention to restrict the sale of sports and energy drinks.

Science.gov (United States)

Jean, G

2017-12-01

High-sugar drinks, including fruit drinks, soft drinks, sports drinks and energy drinks, are of no nutritional value and contribute to the burden of dental disease in all age groups. The manufacturers of sports and energy drinks have elected to target children in their marketing campaigns and promote a misleading association between their products, healthy lifestyles and sporting prowess. The World Health Organization (WHO) has acknowledged that strategies aimed at prevention of dental disease are the only economically viable options for managing the oral health of children in low- and middle-income countries. Developed nations will also be advantaged by preventive programmes given that the cost of providing dental care to those who cannot pay draws valuable resources away from more pressing health issues. The Convention on the Rights of the Child (CRC) obligates governments to develop legislation to protect the health of children. A framework convention modelled on the existing Framework Convention for Tobacco Control, supported by the WHO, would assist governments to proactively legislate to restrict the sale of sports and energy drinks to children. This article will consider how a framework convention would be an advantage with reference to the strategies used by sports and energy drink manufacturers in Australia. © 2017 Australian Dental Association.

Low-energy buildings on mainstream market terms

DEFF Research Database (Denmark)

Quitzau, Maj-Britt; Elle, Morten; Hoffmann, Birgitte

2008-01-01

implementation of strict energy performance requirements in mainstream building. The paper describes how the municipality of Egedal experienced a collapse in regulation for low-energy buildings and what struggles it had to take on in order to convince the mainstream building industry and their customers......This paper looks into the challenge of actually implementing energy efficient technologies and concepts in mainstream new build. The aim of the paper is to point out some of the provisos of promoting low-energy buildings on mainstream market terms, emphasising the need to understand forces working...... against implementation of low-energy buildings. The study is based on actor-network theory, emphasising the relations and struggles that form the basis for pushing for low-energy buildings. The paper is based on a case study of the proactive attempt of a Danish municipality to force through an actual...

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

NARCIS (Netherlands)

Timmers, S.; Konings, E.; Bilet, L.; Houtkooper, R.H.; Weijer, van de T.; Goossens, G.H.; Hoeks, J.; Krieken, van der S.; Ryu, D.; Kersten, A.H.; Moonen-Kornips, E.; Hesselink, M.K.C.; Kunz, I.; Schrauwen-Hinderling, V.B.; Blaak, E.E.; Auwerx, J.; Schrauwen, P.

2011-01-01

Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind

Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

NARCIS (Netherlands)

Timmers, Silvie; Konings, Ellen; Bilet, Lena; Houtkooper, Riekelt H.; van de Weijer, Tineke; Goossens, Gijs H.; Hoeks, Joris; van der Krieken, Sophie; Ryu, Dongryeol; Kersten, Sander; Moonen-Kornips, Esther; Hesselink, Matthijs K. C.; Kunz, Iris; Schrauwen-Hinderling, Vera B.; Blaak, Ellen E.; Auwerx, Johan; Schrauwen, Patrick

2011-01-01

Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind

The role of nuclear energy system for Korean long-term energy supply strategy

International Nuclear Information System (INIS)

Chae, K.N.; Lee, D.G.; Lim, C.Y.; Lee, B.W.

1995-01-01

The energy supply optimization model MESSAGE-III is improved to evaluate the role of nuclear energy system in Korean long-term energy supply strategy. Emphasis is placed on the potential contribution of nuclear energy in case of environmental constraints and energy resource limitation. The time horizon is 1993-2040. A program to forecast useful energy demand is developed, and optimization is performed from the overall energy system to the nuclear energy system. Reactor and fuel cycle strategy and the expanded utilization options for nuclear energy system are suggested. FBRs, HTGRs and thorium fuel cycle would play key roles in the long run. The most important factors for nuclear energy in Korean energy supply strategy would be the availability of fossil fuels, CO 2 reduction regulation, and the supply capability of nuclear energy. (author)

Starving for life: what animal studies can and cannot tell us about the use of caloric restriction to prolong human lifespan.

Science.gov (United States)

Speakman, John R; Hambly, Catherine

2007-04-01

Caloric restriction (CR) is the only experimental nongenetic paradigm known to increase lifespan. It has broad applicability and extends the life of most species through a retardation of aging. There is considerable interest in the use of CR in humans, and animal studies can potentially tell us about the impacts. In this article we highlight some of the things that animal studies can tell us about CR in humans. Rodent studies indicate that the benefits of CR on lifespan extension are related to the extent of restriction. The benefits of CR, however, decline as the age of onset of treatment is delayed. Modeling these impacts suggests that if a 48-y-old man engaged in 30% CR until his normal life expectancy of 78, he might increase his life expectancy by 2.8 y. Exercise and cold exposure induce similar energy deficits, but animals respond to these energy deficits in different ways that have a minor impact on lifespan. Measurements of animal responses when they cease restriction indicate that prolonged CR does not diminish hunger, even though the animals may have been in long-term energy balance. Neuroendocrine profiles support the idea that animals under CR are continuously hungry. The feasibility of restricting intake in humans for many decades without long-term support is questionable. However, what is unclear from animal studies is whether taking drugs that suppress appetite will generate the same impact on longevity or whether the neuroendocrine correlates of hunger play an integral role in mediating CRs effects.

Pronounced energy restriction with elevated protein intake results in no change in proteolysis and reductions in skeletal muscle protein synthesis that are mitigated by resistance exercise.

Science.gov (United States)

Hector, Amy J; McGlory, Chris; Damas, Felipe; Mazara, Nicole; Baker, Steven K; Phillips, Stuart M

2018-01-01

Preservation of lean body mass (LBM) may be important during dietary energy restriction (ER) and requires equal rates of muscle protein synthesis (MPS) and muscle protein breakdown (MPB). Currently, the relative contribution of MPS and MPB to the loss of LBM during ER in humans is unknown. We aimed to determine the impact of dietary protein intake and resistance exercise on MPS and MPB during a controlled short-term energy deficit. Adult men (body mass index, 28.6 ± 0.6 kg/m 2 ; age 22 ± 1 yr) underwent 10 d of 40%-reduced energy intake while performing unilateral resistance exercise and consuming lower protein (1.2 g/kg/d, n = 12) or higher protein (2.4 g/kg/d, n = 12). Pre- and postintervention testing included dual-energy X-ray absorptiometry, primed constant infusion of ring -[ 13 C 6 ]phenylalanine, and 15 [N]phenylalanine to measure acute postabsorptive MPS and MPB; D 2 O to measure integrated MPS; and gene and protein expression. There was a decrease in acute MPS after ER (higher protein, 0.059 ± 0.006 to 0.051 ± 0.009%/h; lower protein, 0.061 ± 0.005 to 0.045 ± 0.006%/h; P resistance exercise (higher protein, 0.067 ± 0.01%/h; lower protein, 0.061 ± 0.006%/h), and integrated MPS followed a similar pattern. There was no change in MPB (energy balance, 0.080 ± 0.01%/hr; ER rested legs, 0.078 ± 0.008%/hr; ER exercised legs, 0.079 ± 0.006%/hr). We conclude that a reduction in MPS is the main mechanism that underpins LBM loss early in ER in adult men.-Hector, A. J., McGlory, C., Damas, F., Mazara, N., Baker, S. K., Phillips, S. M. Pronounced energy restriction with elevated protein intake results in no change in proteolysis and reductions in skeletal muscle protein synthesis that are mitigated by resistance exercise. © FASEB.

Metabolic Effects of a 24-Week Energy-Restricted Intervention Combined with Low or High Dairy Intake in Overweight Women: An NMR-Based Metabolomics Investigation

DEFF Research Database (Denmark)

Zheng, Hong; Lorenzen, J.K.; Astrup, A.

2016-01-01

We investigated the effect of a 24-week energy-restricted intervention with low or high dairy intake (LD or HD) on the metabolic profiles of urine, blood and feces in overweight/obese women by NMR spectroscopy combined with ANOVA-simultaneous component analysis (ASCA). A significant effect of dairy...... metabolism and gut microbial activity. In addition, a significant time effect on the blood metabolome was attributed to a decrease in blood lipid and lipoprotein levels due to the energy restriction. For the fecal metabolome, a trend for a diet effect was found and a series of metabolites, such as acetate...

Comparing long term energy scenarios

International Nuclear Information System (INIS)

Cumo, M.; Simbolotti, G.

2001-01-01

Major projection studies by international organizations and senior analysts have been compared with reference to individual key parameters (population, energy demand/supply, resources, technology, emissions and global warming) to understand trends and implications of the different scenarios. Then, looking at the long term (i.e., 2050 and beyond), parameters and trends have been compared together to understand and quantify whether and when possible crisis or market turbulence might occur due to shortage of resources or environmental problems [it

Projection of primary energy in electricity generation with evaluation of demand and supply of energy in the medium-term horizon (2020), long-term (2035) and very long term (2060)

International Nuclear Information System (INIS)

Mafra, Olga Y.; Alvim, Carlos Feu; Eidelman, Frida; Guimaraes, Leonam dos Santos

2013-01-01

The Global Energy demand and the participation of electricity in scenarios of medium (2020), long (2035) and very long (2060) terms are estimated. It is also evaluated the share of different primary energies in electricity generation and their availability in the country. Three economic scenarios were considered and different hypothesis regarding the participation of nuclear energy were analyzed. (author)

Consequences in Infants That Were Intrauterine Growth Restricted

Directory of Open Access Journals (Sweden)

Erich Cosmi

2011-01-01

Full Text Available Intrauterine growth restriction is a condition fetus does not reach its growth potential and associated with perinatal mobility and mortality. Intrauterine growth restriction is caused by placental insufficiency, which determines cardiovascular abnormalities in the fetus. This condition, moreover, should prompt intensive antenatal surveillance of the fetus as well as follow-up of infants that had intrauterine growth restriction as short and long-term sequele should be considered.

Effects of Diet Restriction and Diet Complexity on Life History Strategies in Side-Blotched Lizards (Uta stansburiana).

Science.gov (United States)

Skinner, Heather M; Durso, Andrew M; Neuman-Lee, Lorin A; Durham, Susan L; Mueller, Sarah D; French, Susannah S

2016-11-01

Organisms must balance energy invested into self-maintenance, reproduction, and somatic growth over their lifetime. In this study, the effects of diet restriction and diet complexity on side-blotched lizards (Uta stansburiana) were analyzed. Thirty male lizards, housed in the laboratory, were fed either an ad libitum or a restricted diet for 18 days (phase 1). Individuals from both treatments were then assigned to a diet of the same quantity of food that was either simple (only crickets) or complex (crickets, cockroaches, waxworms, and mealworms) for 35 days (phase 2). We evaluated (1) how diet restriction affected life history strategies and (2) how diet complexity affected recovery from diet restriction as measured at the end of phase 2 by body mass, snout-vent length, calculated body condition score, wound healing, tail regrowth, bacterial killing ability, oxidative stress, and plasma testosterone and corticosterone concentrations. Lizards without diet restriction allocated more energy to self-maintenance (i.e., maintaining higher body condition scores, healing wounds more quickly) than lizards with diet restriction. Lizards with diet restriction had higher plasma testosterone concentrations and larger increases in snout-vent lengths than those fed ad libitum, which may reflect allocations toward reproduction and somatic growth. A complex diet resulted in better body condition and faster tail regrowth than a simple diet, suggesting that a complex diet enhanced recovery from diet restriction, although long-term life history choices remained unaltered. Finally, lizards on a complex diet consumed substantially less food while maintaining higher body condition, suggesting that key nutrients may be lacking from a simple diet. © 2017 Wiley Periodicals, Inc.

An Integrated Modeling Approach for Forecasting Long-Term Energy Demand in Pakistan

OpenAIRE

Syed Aziz Ur Rehman; Yanpeng Cai; Rizwan Fazal; Gordhan Das Walasai; Nayyar Hussain Mirjat

2017-01-01

Energy planning and policy development require an in-depth assessment of energy resources and long-term demand forecast estimates. Pakistan, unfortunately, lacks reliable data on its energy resources as well do not have dependable long-term energy demand forecasts. As a result, the policy makers could not come up with an effective energy policy in the history of the country. Energy demand forecast has attained greatest ever attention in the perspective of growing population and diminishing fo...

The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes; a pragmatic pilot trial.

Science.gov (United States)

Carter, S; Clifton, P M; Keogh, J B

2016-12-01

Weight loss improves glycaemic control in type 2 diabetes mellitus (T2DM). However, as achieving and maintaining weight loss is difficult, alternative strategies are needed. Our primary aim was to investigate the effects of intermittent energy restriction (IER) compared to continuous energy restriction (CER) on glycated haemoglobin A1c (HbA1c). Secondary aims were to assess effects on weight loss, body composition, medication changes and subjective measures of appetite. Using a 2-day IER method, we expected equal improvements to HbA1c and weight in both groups. Sixty-three overweight or obese participants (BMI 35.2±5kg/m 2 ) with T2DM (HbA1c 7.4±1.3%) (57mmol/mol) were randomised to a 2-day severe energy restriction (1670-2500kJ/day) with 5days of habitual eating, compared to a moderate CER diet (5000-6500kJ/day) for 12weeks. At 12weeks HbA1c (-0.7±0.9% P<0.001) and percent body weight reduction (-5.9±4% P<0.001) was similar in both groups with no group by time interaction. Similar reductions were also seen for medication dosages, all measures of body composition and subjective reports of appetite. In this pilot trial, 2days of IER compared with CER resulted in similar improvements in glycaemic control and weight reduction offering a suitable alternative treatment strategy. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Energy Policy and Long Term Energy Demand in Croatian Households Sector

International Nuclear Information System (INIS)

Puksec, T.; Duic, N.

2011-01-01

Households sector in Croatia represents one of the largest consumers of energy today with around 75,75PJ, which is almost 29% of Croatia's final energy demand. Considering this consumption, implementing different mechanisms that would lead to improvements in energy efficiency in this sector seems relevant. In order to plan future energy systems it is important to know future possibilities and needs regarding energy demand for different sectors. Through this paper long term energy demand projections for Croatian households sector will be shown with a special emphasis on different mechanisms, both financial, legal but also technological that will influence future energy demand scenarios. It is important to see how these mechanisms influence, positive or negative, on future energy demand and which mechanism would be most influential. Energy demand predictions in this paper are based upon bottom-up approach model which combines and process large number of input data. The Model will be compared to Croatian national Energy Strategy and certain difference will be presented. One of the major conclusions shown in this paper is significant possibilities for energy efficiency improvements and lower energy demand in the future, based on careful and rational energy planning. Different financial, legal and technological mechanisms can lead to significant savings in the households sector which also leads to lesser greenhouse gas emissions and lower Croatian dependence on foreign fossil fuels. (author)

18 CFR 35.39 - Affiliate restrictions.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Affiliate restrictions. 35.39 Section 35.39 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Sales of Electric Energy, Capacity and Ancillary Services at Market-Based Rates § 35.39 Affiliate...

Aging, adiposity, and calorie restriction.

Science.gov (United States)

Fontana, Luigi; Klein, Samuel

2007-03-07

Excessive calorie intake and subsequent obesity increases the risk of developing chronic disease and decreases life expectancy. In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span. To evaluate the physiological and clinical implications of calorie restriction with adequate nutrient intake. Search of PubMed (1966-December 2006) using terms encompassing various aspects of calorie restriction, dietary restriction, aging, longevity, life span, adiposity, and obesity; hand search of journals that focus on obesity, geriatrics, or aging; and search of reference lists of pertinent research and review articles and books. Reviewed reports (both basic science and clinical) included epidemiologic studies, case-control studies, and randomized controlled trials, with quality of data assessed by taking into account publication in a peer-reviewed journal, number of animals or individuals studied, objectivity of measurements, and techniques used to minimize bias. It is not known whether calorie restriction extends maximum life span or life expectancy in lean humans. However, calorie restriction in adult men and women causes many of the same metabolic adaptations that occur in calorie-restricted rodents and monkeys, including decreased metabolic, hormonal, and inflammatory risk factors for diabetes, cardiovascular disease, and possibly cancer. Excessive calorie restriction causes malnutrition and has adverse clinical effects. Calorie restriction in adult men and women causes beneficial metabolic, hormonal, and functional changes, but the precise amount of calorie intake or body fat mass associated with optimal health and maximum longevity in humans is not known. In addition, it is possible that even moderate calorie restriction may be harmful in specific patient populations, such as lean persons who have minimal amounts of body fat.

Photo nuclear energy loss term for muon-nucleus interactions based on xi scaling model of QCD

Science.gov (United States)

Roychoudhury, R.

1985-01-01

Extensive air showers (EMC) experiments discovered a significant deviation of the ratio of structure functions of iron and deuteron from unity. It was established that the quark parton distribution in nuclei are different from the corresponding distribution in the nucleus. It was examined whether these results have an effect on the calculation of photo nucleus energy loss term for muon-nucleus nuclear interaction. Though the EMC and SLAC data were restricted to rather large q sq region it is expected that the derivation would persist even in the low q sq domain. For the ratio of iron and deuteron structure function a rather naive least square fit of the form R(x) = a + bx was taken and it is assumed that the formula is valid for the whole q sq region the absence of any knowledge of R(x) for small q sq.

Diversity in OECD energy consumption: Achievements and long-term goals

International Nuclear Information System (INIS)

Heal, D.W.

1990-01-01

Energy consumption in the industrialized world has resumed a rising trend but has been moderated by increased energy efficiency. The demand for energy is also being spread more evenly over a variety of fuels. This paper provides a measure for diversity and examines the implications for energy prices, while reiterating the long-term goal of lower energy consumption

A model for Long-term Industrial Energy Forecasting (LIEF)

Energy Technology Data Exchange (ETDEWEB)

Ross, M. [Lawrence Berkeley Lab., CA (United States)]|[Michigan Univ., Ann Arbor, MI (United States). Dept. of Physics]|[Argonne National Lab., IL (United States). Environmental Assessment and Information Sciences Div.; Hwang, R. [Lawrence Berkeley Lab., CA (United States)

1992-02-01

The purpose of this report is to establish the content and structural validity of the Long-term Industrial Energy Forecasting (LIEF) model, and to provide estimates for the model`s parameters. The model is intended to provide decision makers with a relatively simple, yet credible tool to forecast the impacts of policies which affect long-term energy demand in the manufacturing sector. Particular strengths of this model are its relative simplicity which facilitates both ease of use and understanding of results, and the inclusion of relevant causal relationships which provide useful policy handles. The modeling approach of LIEF is intermediate between top-down econometric modeling and bottom-up technology models. It relies on the following simple concept, that trends in aggregate energy demand are dependent upon the factors: (1) trends in total production; (2) sectoral or structural shift, that is, changes in the mix of industrial output from energy-intensive to energy non-intensive sectors; and (3) changes in real energy intensity due to technical change and energy-price effects as measured by the amount of energy used per unit of manufacturing output (KBtu per constant $ of output). The manufacturing sector is first disaggregated according to their historic output growth rates, energy intensities and recycling opportunities. Exogenous, macroeconomic forecasts of individual subsector growth rates and energy prices can then be combined with endogenous forecasts of real energy intensity trends to yield forecasts of overall energy demand. 75 refs.

A model for Long-term Industrial Energy Forecasting (LIEF)

Energy Technology Data Exchange (ETDEWEB)

Ross, M. (Lawrence Berkeley Lab., CA (United States) Michigan Univ., Ann Arbor, MI (United States). Dept. of Physics Argonne National Lab., IL (United States). Environmental Assessment and Information Sciences Div.); Hwang, R. (Lawrence Berkeley Lab., CA (United States))

1992-02-01

The purpose of this report is to establish the content and structural validity of the Long-term Industrial Energy Forecasting (LIEF) model, and to provide estimates for the model's parameters. The model is intended to provide decision makers with a relatively simple, yet credible tool to forecast the impacts of policies which affect long-term energy demand in the manufacturing sector. Particular strengths of this model are its relative simplicity which facilitates both ease of use and understanding of results, and the inclusion of relevant causal relationships which provide useful policy handles. The modeling approach of LIEF is intermediate between top-down econometric modeling and bottom-up technology models. It relies on the following simple concept, that trends in aggregate energy demand are dependent upon the factors: (1) trends in total production; (2) sectoral or structural shift, that is, changes in the mix of industrial output from energy-intensive to energy non-intensive sectors; and (3) changes in real energy intensity due to technical change and energy-price effects as measured by the amount of energy used per unit of manufacturing output (KBtu per constant $ of output). The manufacturing sector is first disaggregated according to their historic output growth rates, energy intensities and recycling opportunities. Exogenous, macroeconomic forecasts of individual subsector growth rates and energy prices can then be combined with endogenous forecasts of real energy intensity trends to yield forecasts of overall energy demand. 75 refs.

Long-term global nuclear energy and fuel cycle strategies

International Nuclear Information System (INIS)

Krakowski, R.A.

1997-01-01

The Global Nuclear Vision Project is examining, using scenario building techniques, a range of long-term nuclear energy futures. The exploration and assessment of optimal nuclear fuel-cycle and material strategies is an essential element of the study. To this end, an established global E 3 (energy/economics/environmental) model has been adopted and modified with a simplified, but comprehensive and multi-regional, nuclear energy module. Consistent nuclear energy scenarios are constructed using this multi-regional E 3 model, wherein future demands for nuclear power are projected in price competition with other energy sources under a wide range of long-term demographic (population, workforce size and productivity), economic (price-, population-, and income-determined demand for energy services, price- and population-modified GNP, resource depletion, world-market fossil energy prices), policy (taxes, tariffs, sanctions), and top-level technological (energy intensity and end-use efficiency improvements) drivers. Using the framework provided by the global E 3 model, the impacts of both external and internal drivers are investigated. The ability to connect external and internal drivers through this modeling framework allows the study of impacts and tradeoffs between fossil- versus nuclear-fuel burning, that includes interactions between cost, environmental, proliferation, resource, and policy issues

Long-term global nuclear energy and fuel cycle strategies

Energy Technology Data Exchange (ETDEWEB)

Krakowski, R.A. [Los Alamos National Lab., NM (United States). Technology and Safety Assessment Div.

1997-09-24

The Global Nuclear Vision Project is examining, using scenario building techniques, a range of long-term nuclear energy futures. The exploration and assessment of optimal nuclear fuel-cycle and material strategies is an essential element of the study. To this end, an established global E{sup 3} (energy/economics/environmental) model has been adopted and modified with a simplified, but comprehensive and multi-regional, nuclear energy module. Consistent nuclear energy scenarios are constructed using this multi-regional E{sup 3} model, wherein future demands for nuclear power are projected in price competition with other energy sources under a wide range of long-term demographic (population, workforce size and productivity), economic (price-, population-, and income-determined demand for energy services, price- and population-modified GNP, resource depletion, world-market fossil energy prices), policy (taxes, tariffs, sanctions), and top-level technological (energy intensity and end-use efficiency improvements) drivers. Using the framework provided by the global E{sup 3} model, the impacts of both external and internal drivers are investigated. The ability to connect external and internal drivers through this modeling framework allows the study of impacts and tradeoffs between fossil- versus nuclear-fuel burning, that includes interactions between cost, environmental, proliferation, resource, and policy issues.

Energy systems scenario modelling and long term forecasting of hourly electricity demand

Directory of Open Access Journals (Sweden)

Poul Alberg Østergaard

2015-06-01

Full Text Available The Danish energy system is undergoing a transition from a system based on storable fossil fuels to a system based on fluctuating renewable energy sources. At the same time, more of and more of the energy system is becoming electrified; transportation, heating and fuel usage in industry and elsewhere. This article investigates the development of the Danish energy system in a medium year 2030 situation as well as in a long-term year 2050 situation. The analyses are based on scenario development by the Danish Climate Commission. In the short term, it is investigated what the effects will be of having flexible or inflexible electric vehicles and individual heat pumps, and in the long term it is investigated what the effects of changes in the load profiles due to changing weights of demand sectors are. The analyses are based on energy systems simulations using EnergyPLAN and demand forecasting using the Helena model. The results show that even with a limited short-term electric car fleet, these will have a significant effect on the energy system; the energy system’s ability to integrated wind power and the demand for condensing power generation capacity in the system. Charging patterns and flexibility have significant effects on this. Likewise, individual heat pumps may affect the system operation if they are equipped with heat storages. The analyses also show that the long-term changes in electricity demand curve profiles have little impact on the energy system performance. The flexibility given by heat pumps and electric vehicles in the long-term future overshadows any effects of changes in hourly demand curve profiles.

The free energy of the metastable supersaturated vapor via restricted ensemble simulations. III. An extension to the Corti and Debenedetti subcell constraint algorithm

International Nuclear Information System (INIS)

Nie, Chu; Geng, Jun; Marlow, William H.

2016-01-01

In order to improve the sampling of restricted microstates in our previous work [C. Nie, J. Geng, and W. H. Marlow, J. Chem. Phys. 127, 154505 (2007); 128, 234310 (2008)] and quantitatively predict thermal properties of supersaturated vapors, an extension is made to the Corti and Debenedetti subcell constraint algorithm [D. S. Corti and P. Debenedetti, Chem. Eng. Sci. 49, 2717 (1994)], which restricts the maximum allowed local density at any point in a simulation box. The maximum allowed local density at a point in a simulation box is defined by the maximum number of particles N m allowed to appear inside a sphere of radius R, with this point as the center of the sphere. Both N m and R serve as extra thermodynamic variables for maintaining a certain degree of spatial homogeneity in a supersaturated system. In a restricted canonical ensemble, at a given temperature and an overall density, series of local minima on the Helmholtz free energy surface F(N m , R) are found subject to different (N m , R) pairs. The true equilibrium metastable state is identified through the analysis of the formation free energies of Stillinger clusters of various sizes obtained from these restricted states. The simulation results of a supersaturated Lennard-Jones vapor at reduced temperature 0.7 including the vapor pressure isotherm, formation free energies of critical nuclei, and chemical potential differences are presented and analyzed. In addition, with slight modifications, the current algorithm can be applied to computing thermal properties of superheated liquids.

Growth throughout childhood of children born growth restricted

NARCIS (Netherlands)

Beukers, Fenny; Rotteveel, Joost; van Weissenbruch, Mirjam M.; Ganzevoort, Wessel; van Goudoever, Johannes B.; van Wassenaer-Leemhuis, Aleid G.

2017-01-01

Many studies that examine growth in growth-restricted children at birth do not discriminate between fetal growth restriction (FGR) and small for gestational age (SGA). These terms however are not synonymous. In SGA, stunting and increased weight gain have been reported. We do not know if this holds

Investigation of restricted baby Skyrme models

International Nuclear Information System (INIS)

Adam, C.; Romanczukiewicz, T.; Wereszczynski, A.; Sanchez-Guillen, J.

2010-01-01

A restriction of the baby Skyrme model consisting of the quartic and potential terms only is investigated in detail for a wide range of potentials. Further, its properties are compared with those of the corresponding full baby Skyrme models. We find that topological (charge) as well as geometrical (nucleus/shell shape) features of baby Skyrmions are captured already by the soliton solutions of the restricted model. Further, we find a coincidence between the compact or noncompact nature of solitons in the restricted model, on the one hand, and the existence or nonexistence of multi-Skyrmions in the full baby Skyrme model, on the other hand.

The role of protein and carbohydrates for long-term weight control

DEFF Research Database (Denmark)

Perez-Cornago, Aurora; van Baak, Marleen A.; Saris, Wim H. M.

2014-01-01

Current therapies to manage obesity are based on energy restriction and physical activity promotion. However, the role of specific dietary components for long-term weight maintenance is under debate. This review aims to illustrate some lessons from the pan-European Diogenes study, a randomized, c...

Decoding restricted participation in sequential electricity markets

Energy Technology Data Exchange (ETDEWEB)

Knaut, Andreas; Paschmann, Martin

2017-06-15

Restricted participation in sequential markets may cause high price volatility and welfare losses. In this paper we therefore analyze the drivers of restricted participation in the German intraday auction which is a short-term electricity market with quarter-hourly products. Applying a fundamental electricity market model with 15-minute temporal resolution, we identify the lack of sub-hourly market coupling being the most relevant driver of restricted participation. We derive a proxy for price volatility and find that full market coupling may trigger quarter-hourly price volatility to decrease by a factor close to four.

Nuclear energy contribution to restraining greenhouse gas emissions and long-term energy production

International Nuclear Information System (INIS)

Khoda-Bakhsh, R.

2004-01-01

An important source of greenhouse gases, in particular Co 2 , is fossil fuel combustion for energy applications. Since nuclear power is an energy source that does not produce Co 2 , nuclear energy is already making a contribution to restraining greenhouse gas emissions. Because it has been internationally decided to reduce carbon dioxide emission before the year 2005 in order to avoid the green house catastrophy of the earth's atmosphere, and since there is an urgent need of energy especially in the developing countries, there is now a strong demand for alternative energy sources. While the established low cost energy production by light water nuclear fission reactors could be a solution for a period of transition (limited by resources of the light Uranium isotope), fusion energy is of interest for long- term and large scale energy production to provide the increased energy demand

Intrauterine growth restriction: screening, diagnosis, and management.

Science.gov (United States)

Lausman, Andrea; Kingdom, John

2013-08-01

Intrauterine growth restriction (IUGR) is an obstetrical complication, which by definition would screen in 10% of fetuses in the general population. The challenge is to identify the subset of pregnancies affected with pathological growth restriction in order to allow intervention that would decrease morbidity and mortality. The purpose of this guideline is to provide summary statements and recommendations and to establish a framework for screening, diagnosis, and management of pregnancies affected with IUGR. Affected pregnancies are compared with pregnancies in which the fetus is at an appropriate weight for its gestational age. History, physical examination, and laboratory investigations including biochemical markers and ultrasound characteristics of IUGR are reviewed, and a management strategy is suggested. Published literature in English was retrieved through searches of PubMed or MEDLINE, CINAHL, and The Cochrane Library in January 2013 using appropriate controlled vocabulary via MeSH terms (fetal growth restriction and small for gestational age) and key words (fetal growth, restriction, growth retardation, IUGR, low birth weight, small for gestational age). Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. Grey (unpublished) literature was identified through searching the websites of health technology assessment and health technology-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies. The quality of evidence in this document was rated using the criteria described in the Report of the Canadian Task Force on Preventive Health Care (Table). Implementation of the recommendations in this guideline should increase clinician recognition of IUGR and guide intervention where appropriate. Optimal long-term follow-up of neonates diagnosed as IUGR may improve their long-term health.

PENGARUH KEDALAMAN AIR TERHADAP SHORT TERM MEMORY DAN KONSUMSI ENERGI PADA PENYELAM

Directory of Open Access Journals (Sweden)

Rini Dharmastiti

2012-02-01

Full Text Available Penelitian ini akan melihat pengaruh kedalaman air terhadap short term memory dan konsumsi energi penyelam. Penelitian ini mengambil sampel 10 mahasiswa pria dan 5 wanita. Pengukuran performansi short term memory dilakukan dengan cara setiap obyek diperlihatkan deretan 7 angka acak yang diberikan selama 5 detik dan setelah 15 detik kemudian dilakukan pemanggilan kembali informasi yang baru saja diberikan. Setiap obyek diuji sebangak 30 kali untuk setiap kedalaman (1 m; 2,5 m; dan 4 m. Pengukuran konsumsi energi dilakukan dengan menghitung denyut jantung menggunakan metode palpasi. Hasil penelitian menunjukkan bahwa semakin meningkat kedalaman air, maka performasi short term memory penyelam tersebut semakin menurun.  Penurunan ini berlaku untuk pria dan wanita. Penambahan kedalaman ini juga meningkatkan konsumsi energi baik pada pria maupun wanita. Perbedaan jenis kelamin mempengaruhi performansi short term memory secara signifikan. Pria memiliki performansi rata-rata short term memory sebesar 91,67% pada kedalaman 1 m, 90,67% pada kedalaman 2,5 m, dan 86,33% pada kedalaman 4 m. Sedangkan wanita memiliki performansi rata-rata sebesar 86% pada kedalaman 1 m, 84% pada kedalaman 2,5 m, dan 80,67% pada kedalaman 4 m. Rata-rata konsumsi energi pria adalah 3,19 kkal, 3,34 kkal, dan 3,65 kkal pada kedalaman 1 m; 2,5 m; dan 4 m berturut-turut. Sedangkan rata-rata konsumsi energi wanita adalah 3,81 kkal, 4,07 kkal, dan 4,54 kkal pada kedalaman yang sama dengan pria.     Kata kunci : tekanan, kedalaman air, performansi short term memory, konsumsi energi.       This research is to observe water depth effects on short term memory and energy expenditure of diver. This research objects are 10 male and 5 female students. Short term memory performance measurement held by every object has been shown 7 random numerics (as information for 5 seconds and after 15 seconds later they write down the information on a paper. Every object got 30 tests for every

The Electrification of Energy: Long-Term Trends and Opportunities

Energy Technology Data Exchange (ETDEWEB)

Tsao, Jeffrey Y. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fouquet, Roger [London School of Economics and Political Science (United Kingdom); Schubert, E. Fred [Rensselaer Polytechnic Inst., Troy, NY (United States)

2017-11-01

Here, we present and analyze three powerful long-term historical trends in energy, particularly electrical energy, as well as the opportunities and challenges associated with these trends. The first trend is from a world containing a diversity of energy currencies to one whose predominant currency is electricity, driven by electricity’s transportability, exchangeability, and steadily decreasing cost. The second trend is from electricity generated from a diversity of sources to electricity generated predominantly by free-fuel sources, driven by their steadily decreasing cost and long-term abundance. These trends necessitate a just-emerging third trend: from a grid in which electricity is transported uni-directionally, traded at near-static prices, and consumed under direct human control; to a grid in which electricity is transported bi-directionally, traded at dynamic prices, and consumed under human-tailored agential control. Early acceptance and appreciation of these trends will accelerate their remaking of humanity’s energy landscape into one in which energy is much more affordable, abundant and efficiently deployed than it is today; with major economic, geo-political, and environmental benefits to human society.

Potentials for energy savings and long term energy demands for Croatian households sector

DEFF Research Database (Denmark)

Pukšec, Tomislav; Mathiesen, Brian Vad; Duic, Neven

2011-01-01

demand in the future, based on careful and rational energy planning. Different financial, legal and technological mechanisms can lead to significant savings in the households sector which also leads to lesser greenhouse gas emissions and lower Croatian dependence on foreign fossil fuels....... relevant. In order to plan future energy systems it is important to know future possibilities and needs regarding energy demand for different sectors. Through this paper long term energy demand projections for Croatian households sector will be shown with a special emphasis on different mechanisms, both...... financial, legal but also technological that will influence future energy demand scenarios. It is important to see how these mechanisms influence, positive or negative, on future energy demand and which mechanism would be most influential. Energy demand predictions in this paper are based upon bottom...

Potentials for energy savings and long term energy demands for Croatian households sector

DEFF Research Database (Denmark)

Pukšec, Tomislav; Mathiesen, Brian Vad; Duic, Neven

2013-01-01

demand in the future, based on careful and rational energy planning. Different financial, legal and technological mechanisms can lead to significant savings in the households sector which also leads to lesser greenhouse gas emissions and lower Croatian dependence on foreign fossil fuels....... relevant. In order to plan future energy systems it is important to know future possibilities and needs regarding energy demand for different sectors. Through this paper long term energy demand projections for Croatian households sector will be shown with a special emphasis on different mechanisms, both...... financial, legal but also technological that will influence future energy demand scenarios. It is important to see how these mechanisms influence, positive or negative, on future energy demand and which mechanism would be most influential. Energy demand predictions in this paper are based upon bottom...

Short-term energy outlook: Quarterly projections, fourth quarter 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-10-14

The Energy Information Administration (EIA) prepares quarterly short-term energy supply, demand, and price projections for printed publication in January, April, July, and October in the Short-Term Energy Outlook. The details of these projections, as well as monthly updates on or about the 6th of each interim month, are available on the internet at: www.eia.doe.gov/emeu/steo/pub/contents.html. The forecast period for this issue of the Outlook extends from the fourth quarter of 1997 through the fourth quarter of 1998. Values for the fourth quarter of 1997, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in EIA`s Weekly Petroleum Status Report) or are calculated from model simulations that use the latest exogenous information available (for example, electricity sales and generation are simulated by using actual weather data). The historical energy data, compiled in the fourth quarter 1997 version of the Short-Term Integrated Forecasting System (STIFS) database, are mostly EIA data regularly published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding. The STIFS model is driven principally by three sets of assumptions or inputs: estimates of key macroeconomic variables, world oil price assumptions, and assumptions about the severity of weather. 19 tabs.

Short-term energy outlook. Quarterly projections, 2nd quarter 1994

Energy Technology Data Exchange (ETDEWEB)

1994-05-01

The Energy Information Administration (EIA) prepares quarterly, short-term energy supply, demand, and price projections for publication in February, May, August, and November in the Short-Term Energy Outlook (Outlook). An annual supplement analyzes the performance of previous forecasts, compares recent cases with those of other forecasting services, and discusses current topics related to the short-term energy markets. The forecast period for this issue of the Outlook extends from the second quarter of 1994 through the fourth quarter of 1995. Values for the first quarter of 1994, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in the Weekly Petroleum Status Report) or are calculated from model simulations using the latest exogenous information available. The historical energy data, compiled into the second quarter 1994 version of the Short-Term Integrated Forecasting System (STIFS) database, are mostly EIA data regularly published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding. The STIFS database is archived quarterly and is available from the National Technical Information Service. The cases are produced using the STIFS. The STIFS model is driven principally by three sets of assumptions or inputs: estimates of key macroeconomic variables, world oil price assumptions, and assumptions about the severity of weather. Macroeconomic estimates are produced by DRI/McGraw-Hill but are adjusted by EIA to reflect EIA assumptions about the world price of crude oil, energy product prices, and other assumptions which may affect the macroeconomic outlook. The EIA model is available on computer tape from the National Technical Information Service.

Global economics/energy/environmental (E3) modeling of long-term nuclear energy futures

International Nuclear Information System (INIS)

Krakowski, R.A.; Davidson, J.W.; Bathke, C.G.; Arthur, E.D.; Wagner, R.L. Jr.

1997-01-01

A global energy, economics, environment (E 3 ) model has been adopted and modified with a simplified, but comprehensive and multi-regional, nuclear energy module. Using this model, consistent nuclear energy scenarios are constructed. A spectrum of future is examined at two levels in a hierarchy of scenario attributes in which drivers are either external or internal to nuclear energy. Impacts of a range of nuclear fuel-cycle scenarios are reflected back to the higher-level scenario attributes. An emphasis is placed on nuclear materials inventories (in magnitude, location, and form) and their contribution to the long-term sustainability of nuclear energy and the future competitiveness of both conventional and advanced nuclear reactors

Long term planning for wind energy development

International Nuclear Information System (INIS)

Trinick, M.

1995-01-01

In a planning system intended to be governed primarily by policies in statutory plans a reasonable horizon for long term planning is 10 years or longer. Because of statutory requirements, developers have no option but to pay due regard to, and take a full part in, long term planning. The paper examines the type of policies which have emerged in the last few years to cater for wind energy development. It canvasses the merits of different types of policies. Finally, it discusses the policy framework which may emerge to cater for development outside NFFO. (Author)

A novel inclusion of intermittent generation resources in long term energy auctions

International Nuclear Information System (INIS)

Marambio, Rodrigo; Rudnick, Hugh

2017-01-01

Long term energy auctions are positioning as a valuable tool in order to attract new investments into power systems, especially in Latin American countries where emergent economies characteristics and their correspondent risks are usually present. Even though the focus of these auctions is the long term, there are short term issues involved which actual auction designs fail to include, resulting in an energy allocation that is not necessarily optimal for the system, a condition which becomes more evident in the presence of intermittent renewable technologies. A novel mechanism is formulated to obtain the optimal allocation in long term energy auctions, considering short term generation profiles from both intermittent and conventional base load technologies, and also their risk aversions. The proposed mechanism is developed and simulations are made for some scenarios in the Chilean power market, with different levels of renewable penetration. Significant cost savings are achieved for the final consumers in relation to energy purchases, in comparison with a mechanism that follows the demand profile. As more renewable intermittent capacity enters the power system it is evident the need for changes in the energy auctions allocation mechanisms, including elements to exploit the synergies among participants in the short term. - Highlights: • Risk management consideration in technology neutral auctions allocation. • Allocation mechanism in technology neutral auctions with intermittent technologies. • Renewable and conventional technologies energy auction offer curves. • Increase bid prices in auctions as a consequence of solar technology support.

Long-term dietary restriction up-regulates activity and expression of renal arginase II in aging mice.

Science.gov (United States)

Majaw, T; Sharma, R

2017-06-01

Arginase II is a mitochondrial enzyme that catalyses the hydrolysis of L-arginine into urea and ornithine. It is present in other extra-hepatic tissues that lack urea cycle. Therefore, it is plausible that arginase II has a physiological role other than urea cycle which includes polyamine, proline, glutamate synthesis and regulation of nitric oxide production. The high expression of arginase II in kidney, among extrahepatic tissues, might have an important role associated with kidney functions. The present study is aimed to determine the age-associated alteration in the activity and expression of arginase II in the kidney of mice of different ages. The effect of dietary restriction to modulate the agedependent changes of arginase II was also studied. Results showed that renal arginase II activity declines significantly with the progression of age (p less than 0.01 and p less than 0.001 in 6- and 18-month-old mice, respectively as compared to 2-month old mice) and is due to the reduction in its protein as well as the mRNA level (p less than 0.001 in both 6- and 18-month-old mice as compared to 2-month-old mice). Long-term dietary restriction for three months has significantly up-regulated arginase II activity and expression level in both 2- and 18-month-old mice (p less than 0.01 and p less than 0.001, respectively as compared to AL group). These findings clearly indicate that the reducing level of arginase II during aging might have an impact on the declining renal functions. This age-dependent down-regulation of arginase II in the kidney can be attenuated by dietary restriction which may help in the maintenance of such functions.

10 CFR 2.903 - Protection of restricted data and national security information.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Protection of restricted data and national security... Restricted Data and/or National Security Information § 2.903 Protection of restricted data and national security information. Nothing in this subpart shall relieve any person from safeguarding Restricted Data or...

Modeling of long-term energy system of Japan

International Nuclear Information System (INIS)

Gotoh, Yoshitaka; Sato, Osamu; Tadokoro, Yoshihiro

1999-07-01

In order to analyze the future potential of reducing carbon dioxide emissions, the long-term energy system of Japan was modeled following the framework of the MARKAL model, and the database of energy technology characteristics was developed. First, a reference energy system was built by incorporating all important energy sources and technologies that will be available until the year 2050. This system consists of 25 primary energy sources, 33 technologies for electric power generation and/or low temperature heat production, 97 technologies for energy transformation, storage, and distribution, and 170 end-use technologies. Second, the database was developed for the characteristics of individual technologies in the system. The characteristic data consists of input and output of energy carriers, efficiency, availability, lifetime, investment cost, operation and maintenance cost, CO 2 emission coefficient, and others. Since a large number of technologies are included in the system, this report focuses modeling of a supply side, and involves the database of energy technologies other than for end-use purposes. (author)

The role and position of nuclear energy in the long-term energy supply of China

International Nuclear Information System (INIS)

Bao Yunqiao

1992-03-01

The history for development of world nuclear energy and policies in various countries are retrospected, and the development of world nuclear energy is reviewed. On the basis of analysis for the economy of nuclear power in abroad, it is verified that the cost of nuclear power is cheaper than that of coal-fired power. In the future, the nuclear power is still competitive in economy. The prospect for long-term energy supply in China is predicted on the present situation of energy industry. It is estimated that the gap between energy demands and supply will become larger and larger. The solution is to develop nuclear energy in south-east area. The long-term demands of electricity and electrical resources are estimated in China, and if nuclear energy is utilized, it will optimize the constitution of electricity. The economy of nuclear power is also evaluated. It is expected that the nuclear power will be cheaper than that of coal-fired power in China after equipment are made domestically and serially. From the analysis of the conditions of communication, transportation and pollution, the development of nuclear energy will reduce the tension of transportation and improve the environmental quality. Finally, the prospect of developing nuclear heating and the supply level of uranium resources in China are analyzed

Energy Resource Planning. Optimal utilization of energy resources

International Nuclear Information System (INIS)

Miclescu, T.; Domschke, W.; Bazacliu, G.; Dumbrava, V.

1996-01-01

For a thermal power plants system, the primary energy resources cost constitutes a significant percentage of the total system operational cost. Therefore a small percentage saving in primary energy resource allocation cost for a long term, often turns out to be a significant monetary value. In recent years, with a rapidly changing fuel supply situation, including the impact of energy policies changing, this area has become extremely sensitive. Natural gas availability has been restricted in many areas, coal production and transportation cost have risen while productivity has decreased, oil imports have increased and refinery capacity failed to meet demand. The paper presents a mathematical model and a practical procedure to solve the primary energy resource allocation. The objectives is to minimise the total energy cost over the planning period subject to constraints with regards to primary energy resource, transportation and energy consumption. Various aspects of the proposed approach are discussed, and its application to a power system is illustrated.(author) 2 figs., 1 tab., 3 refs

Long-term affected energy production of waste to energy technologies identified by use of energy system analysis

DEFF Research Database (Denmark)

Münster, Marie; Meibom, Peter

2010-01-01

Affected energy production is often decisive for the outcome of consequential life-cycle assessments when comparing the potential environmental impact of products or services. Affected energy production is however difficult to determine. In this article the future long-term affected energy...... production is identified by use of energy system analysis. The focus is on different uses of waste for energy production. The Waste-to-Energy technologies analysed include co-combustion of coal and waste, anaerobic digestion and thermal gasification. The analysis is based on optimization of both investments...... and production of electricity, district heating and bio-fuel in a future possible energy system in 2025 in the countries of the Northern European electricity market (Denmark, Norway, Sweden, Finland and Germany). Scenarios with different CO2 quota costs are analysed. It is demonstrated that the waste...

Kamm on Inviolability and Agent-Relative Restrictions

DEFF Research Database (Denmark)

Lippert-Rasmussen, Kasper

2009-01-01

Abstract  Agent-relative restrictions prohibit minimizing violations: that is, they require us not to minimize the total number of their violations by violating them ourselves. Frances Kamm has explained this prohibition in terms of the moral worth of persons, which, in turn, she explains in term...

Kamm on Inviolability and Agent-Relative Restrictions

DEFF Research Database (Denmark)

Lippert-Rasmussen, Kasper

2009-01-01

Abstract  Agent-relative restrictions prohibit minimizing violations: that is, they require us not to minimize the total number of their violations by violating them ourselves. Frances Kamm has explained this prohibition in terms of the moral worth of persons, which, in turn, she explains in terms...

Analysis of Final Energy Demand by Sector in Malaysia using MAED Model

International Nuclear Information System (INIS)

Kumar, M.; Muhammed Zulfakar Mohd Zolkaffly; Alawiah Musa

2011-01-01

Energy supply security is important in ensuring a long term supply to fulfill the growing energy demand. This paper presents the use of IAEA energy planning tool, Model for Analysis of Energy Demand (MAED) to analyze, simulate and compare final energy demand by five different sectors in Malaysia under some assumptions, bounds and restrictions and the outcome can be used for planning of energy supply in future. (author)

Long-term energy planning with uncertain environmental performance metrics

International Nuclear Information System (INIS)

Parkinson, Simon C.; Djilali, Ned

2015-01-01

Highlights: • Environmental performance uncertainty considered in a long-term energy planning model. • Application to electricity generation planning in British Columbia. • Interactions with climate change mitigation and adaptation strategy are assessed. • Performance risk-hedging impacts the technology investment strategy. • Sensitivity of results to model formulation is discussed. - Abstract: Environmental performance (EP) uncertainties span a number of energy technology options, and pose planning risk when the energy system is subject to environmental constraints. This paper presents two approaches to integrating EP uncertainty into the long-term energy planning framework. The methodologies consider stochastic EP metrics across multiple energy technology options, and produce a development strategy that hedges against the risk of exceeding environmental targets. Both methods are compared within a case study of emission-constrained electricity generation planning in British Columbia, Canada. The analysis provides important insight into model formulation and the interactions with concurrent environmental policy uncertainties. EP risk is found to be particularly important in situations where environmental constraints become increasingly stringent. Model results indicate allocation of a modest risk premium in these situations can provide valuable hedging against EP risk

Term value/band-gap energy correlations for solid rare gas excitons

International Nuclear Information System (INIS)

Anon.

1987-01-01

Term value/ionization energy correlation algorithms have proven to be of considerable utility in the assignment of atomic and molecular Rydberg states. Many examples of empirical term value/ionization energy correlations are known for diverse classes of atoms and molecules. The purpose of this paper is to demonstrate that similar correlations are also obtained for excitons in rare gas solids

Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction.

Science.gov (United States)

Murphy, Caoileann H; Shankaran, Mahalakshmi; Churchward-Venne, Tyler A; Mitchell, Cameron J; Kolar, Nathan M; Burke, Louise M; Hawley, John A; Kassis, Amira; Karagounis, Leonidas G; Li, Kelvin; King, Chelsea; Hellerstein, Marc; Phillips, Stuart M

2018-06-01

Strategies to enhance the loss of fat while preserving muscle mass during energy restriction are of great importance to prevent sarcopenia in overweight older adults. We show for the first time that the integrated rate of synthesis of numerous individual contractile, cytosolic and mitochondrial skeletal muscle proteins was increased by resistance training (RT) and unaffected by dietary protein intake pattern during energy restriction in free-living, obese older men. We observed a correlation between the synthetic rates of skeletal muscle-derived proteins obtained in serum (creatine kinase M-type, carbonic anhydrase 3) and the synthetic rates of proteins obtained via muscle sampling; and that the synthesis rates of these proteins in serum revealed the stimulatory effects of RT. These results have ramifications for understanding the influence of RT on skeletal muscle and are consistent with the role of RT in maintaining muscle protein synthesis and potentially supporting muscle mass preservation during weight loss. We determined how the pattern of protein intake and resistance training (RT) influenced longer-term (2 weeks) integrated myofibrillar protein synthesis (MyoPS) during energy restriction (ER). MyoPS and proteome kinetics were measured during 2 weeks of ER alone and 2 weeks of ER plus RT (ER + RT) in overweight/obese older men. Participants were randomized to consume dietary protein in a balanced (BAL: 25% daily protein per meal × 4 meals) or skewed (SKEW: 7:17:72:4% daily protein per meal) pattern (n = 10 per group). Participants ingested deuterated water during the consecutive 2-week periods, and skeletal muscle biopsies and serum were obtained at the beginning and conclusion of ER and ER + RT. Bulk MyoPS (i.e. synthesis of the myofibrillar protein sub-fraction) and the synthetic rates of numerous individual skeletal muscle proteins were quantified. Bulk MyoPS was not affected by protein distribution during ER or ER + RT (ER: BAL = 1.24�

Main tendencies meeting future energy demands

International Nuclear Information System (INIS)

Flach, G.; Riesner, W.; Ufer, D.

1989-09-01

The economic development in the German Democratic Republic within the preceding 10 years has proved that future stable economic growth of about 4 to 4.5% per annum is only achievable by ways including methods of saving resources. This requires due to the close interdependences between the social development and the level of the development in the energy sector long-term growth rates of the national income of 4 to 4.5% per annum at primary energy growth rates of less than 1% per annum. It comprises three main tendencies: 1. Organization of a system with scientific-technical, technological, economic structural-political and educational measures ensuring in the long term less increase of the energy demand while keeping the economic growth at a constant level. 2. The long-term moderate extension and modernization of the GDR's energy basis is characterized by continuing use of the indigenous brown coal resources for the existing power plant capacities and for district heating. 3. The use of modern and safe nuclear power technologies defines a new and in future more and more important element of the energy basis. Currently about 10% of electricity in the GDR are covered by nuclear energy, in 2000 it will be one third, after 2000 the growth process will continue. The experience shows: If conditions of deepened scientific consideration of all technological processes and the use of modern diagnosis and computer technologies as well as permanent improvement of the safety-technological components and equipment are guaranteed an increasing use of such systems for the production of electricity and heat is socially acceptable. Ensuring a high level of education and technical training of everyone employed in the nuclear energy industry, strict safety restrictions and independent governmental control of these restrictions are important preconditions for the further development in this field. 3 refs, 5 tabs

Influence of pre and postnatal energy restriction on the productive performance of ewes and lambs

Directory of Open Access Journals (Sweden)

Filipe Alexandre Boscaro de Castro

2012-04-01

Full Text Available The objective of this study was to evaluate the influence of feeding energy levels during the last third of gestation and lactation on performance of ewes and lambs up to weaning. The experiment was carried out in the sheep raising sector of Universidade Estadual de Londrina (UEL, from August to December of 2007. Thirty-two adult lambs with 105 days of gestation, average live weight of 57.55 kg and average body condition scores of 3.42 were used in the beginning of the experiment. The animals were confined in collective pens, distributed randomly in three treatments: 2.4; 2.2 and 2.0 Mcal of metabolizable energy (ME/kg of dry matter (DM. Feed supply was ad libitum during the last third of gestation and lactation. Weaning occurred at 70 days. Body weight, body condition score and milk production of ewes and body weight of the lambs were analyzed. There were no significant differences for body weight and body condition of ewes at lambing; however, the level of 2.4 Mcal enabled better results for those characteristics at weaning and higher gain in weight and body condition scoring during the experiment. Severe energetic restriction (2.0 Mcal ME/kg DM determined lower average daily milk production. Lambs from levels 2.4 and 2.2 presented similar weights in all measurements and were superior to those in level 2.0. Lambs from level 2.4 presented higher average weight gain from birth to weaning. The energetic restriction upon lambs at the end of gestation and during lactation limits the performance of ewes and lambs up to weaning.

Short-term influences and long-term fundamentals: stabilizing and destabilizing effects in the energy industries

Energy Technology Data Exchange (ETDEWEB)

Robinson, Silvan [Royal Inst. of International Affairs, London (United Kingdom)

1992-10-01

The ideology of the market economy has become dominant in all walks of economic life and the energy industries are no exception. In the oil business, the stabilizing structures of the international majors and of long-term prices have been replaced by industrial fragmentation and market price mechanisms. Monopolies in other energy industries are being progressively dismantled. This live experiment is being conducted on an industry which historically has suffered from feast and famine economics and has tried to protect itself through various forms of cartelization. The short-term effects of this open market have so far tended to improve flexibility and consumer choice. The price instability has proved manageable. The danger is that cash flow compression will reduced investments in the future and an ability to make very long lead time shifts in the energy mix. For this some government intervention in markets is necessary. (author).

Immediate metabolic consequences of intrauterine growth restriction and low birthweight.

Science.gov (United States)

Bhatia, Jatinder; Gates, Amy

2013-01-01

Optimal fetal growth resulting in a 'normally grown' term infant is of paramount importance for assuring a healthy start for postnatal growth and development. Fetal, infant and childhood growth restriction is an important clinical problem for obstetricians, neonatologists, pediatricians and globally, for public health. Worldwide, an estimated 20 million infants are born with low birthweight and a substantial proportion are small for gestational age. Many advances have been made in defining growth restriction by prenatal techniques, thus allowing the recognition of intrauterine growth restriction. Distinguishing infants who are small but have appropriate growth potential from those with growth restriction is important in order to apply obstetric surveillance, anticipate neonatal problems and plan for postneonatal guidance. It is clear that the fetus in growth-restricted pregnancies has limited supply of nutrients and oxygen. The resultant changes, if involving the placenta as well, can lead to circulatory and metabolic changes affecting both short- and long-term survival and development. In this paper, the causes and immediate consequence of being born with low birthweight, intrauterine growth restriction or small for gestational age will be discussed. Copyright © 2013 Nestec Ltd., Vevey/S. Karger AG, Basel.

The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction.

Science.gov (United States)

Lusseau, David; Mitchell, Sharon E; Barros, Ceres; Derous, Davina; Green, Cara; Chen, Luonan; Han, Jing-Dong Jackie; Wang, Yingchun; Promislow, Daniel E L; Douglas, Alex; Speakman, John R

2015-08-25

Animals have to adjust their activities when faced with caloric restriction (CR) to deal with reduced energy intake. If CR is pronounced, allostasis can push individuals into alternate physiological states which can result in important health benefits across a wide range of taxa. Here we developed a new approach to determine the changes in behavioural phenotype associated with different levels of CR. We exposed C57BL/6 male mice to graded CR (from 0 to 40%) for three months and defined their behavioural phenotype using hidden Markov models of their movement and body temperature. All 40% CR mice exhibited a state-shift in behavioural phenotype and only some exposed to 30% CR did. We show for the first time that mice changed their activity characteristics rather than changed their activities. This new phenotyping approach provides an avenue to determine the mechanisms linking CR to healthspan.

Short-term energy outlook, quarterly projections, second quarter 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-04-01

The Energy Information Administration (EIA) prepares quarterly short-term energy supply, demand, and price projections. The details of these projections, as well as monthly updates, are available on the Internet at: www.eia.doe.gov/emeu/steo/pub/contents.html. The paper discusses outlook assumptions; US energy prices; world oil supply and the oil production cutback agreement of March 1998; international oil demand and supply; world oil stocks, capacity, and net trade; US oil demand and supply; US natural gas demand and supply; US coal demand and supply; US electricity demand and supply; US renewable energy demand; and US energy demand and supply sensitivities. 29 figs., 19 tabs.

Evolution of holographic dark energy with interaction term Q∝ Hρde ...

Indian Academy of Sciences (India)

A flat FLRW Universe with dark matter and dark energy, which are interacting witheach other, is considered. The dark energy is represented by the holographic dark energy model and the interaction term is taken as proportional to the dark energy density. We have studied the cosmological evolution and analysed the ...

Economic effects of western Federal land-use restrictions on U.S. coal markets

Science.gov (United States)

Watson, William Downing; Medlin, A.L.; Krohn, K.K.; Brookshire, D.S.; Bernknopf, R.L.

1991-01-01

Current regulations on land use in the Western United States affect access to surface minable coal resources. This U.S. Geological Survey study analyzes the long-term effects of Federal land-use restrictions on the national cost of meeting future coal demands. The analysis covers 45 years. The U.S. Bureau of Land Management has determined the environmental, aesthetic, and economic values of western Federal coal lands and has set aside certain areas from surface coal mining to protect other valued land uses, including agricultural, environmental, and aesthetic uses. Although there are benefits to preserving natural areas and to developing areas for other land uses, these restrictions produce long-term national and regional costs that have not been estimated previously. The Dynamic Coal Allocation Model integrates coal supply (coal resource tonnage and coal quality by mining cost for 60 coal supply regions) with coal demand (in 243 regions) for the entire United States. The model makes it possible to evaluate the regional economic impacts of coal supply restrictions wherever they might occur in the national coal market. The main factors that the economic methodology considers are (1) coal mining costs, (2) coal transportation costs, (3) coal flue gas desulfurization costs, (4) coal demand, (5) regulations to control sulfur dioxide discharges, and (6) specific reductions in coal availability occurring as a result of land-use restrictions. The modeling system combines these economic factors with coal deposit quantity and quality information--which is derived from the U.S. Geological Survey's National Coal Resources Data System and the U.S. Department of Energy's Demonstrated Reserve Base--to determine a balance between supply and demand so that coal is delivered at minimum cost.

Energy Systems Scenario Modelling and Long Term Forecasting of Hourly Electricity Demand

DEFF Research Database (Denmark)

Alberg Østergaard, Poul; Møller Andersen, Frits; Kwon, Pil Seok

2015-01-01

. The results show that even with a limited short term electric car fleet, these will have a significant effect on the energy system; the energy system’s ability to integrate wind power and the demand for condensing power generation capacity in the system. Charging patterns and flexibility have significant...... or inflexible electric vehicles and individual heat pumps, and in the long term it is investigated what the effects of changes in the load profiles due to changing weights of demand sectors are. The analyses are based on energy systems simulations using EnergyPLAN and demand forecasting using the Helena model...... effects on this. Likewise, individual heat pumps may affect the system operation if they are equipped with heat storages. The analyses also show that the long term changes in electricity demand curve profiles have little impact on the energy system performance. The flexibility given by heat pumps...

Health Benefits of Fasting and Caloric Restriction.

Science.gov (United States)

Golbidi, Saeid; Daiber, Andreas; Korac, Bato; Li, Huige; Essop, M Faadiel; Laher, Ismail

2017-10-23

Obesity and obesity-related diseases, largely resulting from urbanization and behavioral changes, are now of global importance. Energy restriction, though, is associated with health improvements and increased longevity. We review some important mechanisms related to calorie limitation aimed at controlling of metabolic diseases, particularly diabetes. Calorie restriction triggers a complex series of intricate events, including activation of cellular stress response elements, improved autophagy, modification of apoptosis, and alteration in hormonal balance. Intermittent fasting is not only more acceptable to patients, but it also prevents some of the adverse effects of chronic calorie restriction, especially malnutrition. There are many somatic and potentially psychologic benefits of fasting or intermittent calorie restriction. However, some behavioral modifications related to abstinence of binge eating following a fasting period are crucial in maintaining the desired favorable outcomes.

Long vs. short-term energy storage:sensitivity analysis.

Energy Technology Data Exchange (ETDEWEB)

Schoenung, Susan M. (Longitude 122 West, Inc., Menlo Park, CA); Hassenzahl, William V. (,Advanced Energy Analysis, Piedmont, CA)

2007-07-01

This report extends earlier work to characterize long-duration and short-duration energy storage technologies, primarily on the basis of life-cycle cost, and to investigate sensitivities to various input assumptions. Another technology--asymmetric lead-carbon capacitors--has also been added. Energy storage technologies are examined for three application categories--bulk energy storage, distributed generation, and power quality--with significant variations in discharge time and storage capacity. Sensitivity analyses include cost of electricity and natural gas, and system life, which impacts replacement costs and capital carrying charges. Results are presented in terms of annual cost, $/kW-yr. A major variable affecting system cost is hours of storage available for discharge.

Long term energy system analysis of Japan based on 'options for energy and environment' by the energy and environmental council

International Nuclear Information System (INIS)

Hagiwara, Naoto; Kurosawa, Atsushi

2013-01-01

Implications to Japanese energy system are discussed especially in terms of primary energy supply and power generation portfolio, using sensitivity analysis results by an optimization type energy model based on TIMES modeling framework. We updated energy service demand, efficiency in energy conversion and consumption, and power generation costs based on the recent energy policy document called 'Options for Energy and Environment'. The time horizon of the model is 2050. The sensitivity analysis results are presented for 'Three scenarios for 2030' including nuclear phase out scenarios with/without CO 2 emission constraint. The results are compared with 'Options for Energy and Environment'. (author)

Non-minimally coupled quintessence dark energy model with a cubic galileon term: a dynamical system analysis

Science.gov (United States)

Bhattacharya, Somnath; Mukherjee, Pradip; Roy, Amit Singha; Saha, Anirban

2018-03-01

We consider a scalar field which is generally non-minimally coupled to gravity and has a characteristic cubic Galilean-like term and a generic self-interaction, as a candidate of a Dark Energy model. The system is dynamically analyzed and novel fixed points with perturbative stability are demonstrated. Evolution of the system is numerically studied near a novel fixed point which owes its existence to the Galileon character of the model. It turns out that demanding the stability of this novel fixed point puts a strong restriction on the allowed non-minimal coupling and the choice of the self-interaction. The evolution of the equation of state parameter is studied, which shows that our model predicts an accelerated universe throughout and the phantom limit is only approached closely but never crossed. Our result thus extends the findings of Coley, Dynamical systems and cosmology. Kluwer Academic Publishers, Boston (2013) for more general NMC than linear and quadratic couplings.

An overview of Ontario's 2013 long term energy plan

International Nuclear Information System (INIS)

Jobe, C.

2014-01-01

Ontario's 2013 Long Term Energy /Plan (LTEP) takes a pragmatic approach. The plan is designed to balance the following five principles namely: Cost effectiveness, Reliability, Clean energy, Community engagement, and Emphasis on conservation and demand management before building new generation. By taking a pragmatic and flexible approach and balancing these principles, Ontario's 2013 Long Term Energy Plan builds on the foundation laid by the 2010 LTEP while also lowering the projected total system costs. The key elements of the 2013 LTEP are described in this paper by highlighting the major features of these elements. (author)

Can energy forecasts be improved?

International Nuclear Information System (INIS)

Rech, O.; Alban, P.

2000-01-01

Within the present day context of energy, characterized by the gap between short term trends and long term risks, forecasting takes on particular interest. We based our study on the evaluation of the results of some of these long term (2020) and very long term (2050) forecasts. This article looks at the overall demand for energy, whereas the evolution of each primary energy will be handled in a future article. We are restricting our analysis to a global level despite the inherent limitations of such a choice. Our approach mainly concentrates on the dynamics of the phenomena. Thus, we have noticed a simultaneous slowing down since the 1960's of the demography, economy and energy. The revenue and energy consumption per capita do not elude this tendency. At the same time, energy production leads a steep downward tendency. All in all, the forecasts have a tendency to conflict more or less with these changes. In the majority of the scenarios the anticipated rhythms of economic change and energy consumption would indicate a sudden and abrupt inverse of current dynamics. We have noticed that the single use of the average annual rate of change is insufficient to clearly present the long term tendencies that follow curved and not linear paths. Diagnostic errors made in past analyses are likely to affect the models for forecasting, for which the inferred dynamics have not been fully apprehended

Global economics/energy/environmental (E{sup 3}) modeling of long-term nuclear energy futures

Energy Technology Data Exchange (ETDEWEB)

Krakowski, R.A.; Davidson, J.W.; Bathke, C.G.; Arthur, E.D.; Wagner, R.L. Jr.

1997-09-01

A global energy, economics, environment (E{sup 3}) model has been adopted and modified with a simplified, but comprehensive and multi-regional, nuclear energy module. Using this model, consistent nuclear energy scenarios are constructed. A spectrum of future is examined at two levels in a hierarchy of scenario attributes in which drivers are either external or internal to nuclear energy. Impacts of a range of nuclear fuel-cycle scenarios are reflected back to the higher-level scenario attributes. An emphasis is placed on nuclear materials inventories (in magnitude, location, and form) and their contribution to the long-term sustainability of nuclear energy and the future competitiveness of both conventional and advanced nuclear reactors.

Restricted open-shell Kohn-Sham theory: N unpaired electrons

International Nuclear Information System (INIS)

Schulte, Marius; Frank, Irmgard

2010-01-01

Graphical abstract: High-spin or low-spin? The lowest-lying states for different multiplicities of iron complexes are described with a combination of restricted open-shell Kohn-Sham theory and Car-Parrinello molecular dynamics. - Abstract: We present an energy expression for restricted open-shell Kohn-Sham theory for N unpaired electrons. It is shown that it is possible to derive an explicit energy expression for all low-spin multiplets of systems that exhibit neither radial nor cylindrical symmetry. The approach was implemented in the CPMD code and tested for iron complexes.

Prospects of renewable energy sources in India: Prioritization of alternative sources in terms of Energy Index

International Nuclear Information System (INIS)

Jha, Shibani K.; Puppala, Harish

2017-01-01

The growing energy demand in progressing civilization governs the exploitation of various renewable sources over the conventional sources. Wind, Solar, Hydro, Biomass, and waste & Bagasse are the various available renewable sources in India. A reliable nonconventional geothermal source is also available in India but it is restricted to direct heat applications. This study archives the status of renewable alternatives in India. The techno economic factors and environmental aspects associated with each of these alternatives are discussed. This study focusses on prioritizing the renewable sources based on a parameter introduced as Energy Index. This index is evaluated using cumulative scores obtained for each of the alternatives. The cumulative score is obtained by evaluating each alternative over a range of eleven environmental and techno economic criteria following Fuzzy Analytical Hierarchy Process. The eleven criteria's considered in the study are Carbon dioxide emissions (CO 2 ), Sulphur dioxide emissions (SO 2 ), Nitrogen oxide emissions (NO x ), Land requirement, Current energy cost, Potential future energy cost, Turnkey investment, Capacity factor, Energy efficiency, Design period and Water consumption. It is concluded from the study that the geothermal source is the most preferable alternative with highest Energy Index. Hydro, Wind, Biomass and Solar sources are subsequently preferred alternatives. - Highlights: • FAH process is used to obtain cumulative score for each renewable alternative. • Cumulative score is normalized by highest score of ideal source. • Energy Index shows how best a renewable alternative is. • Priority order is obtained for alternatives based on Energy Index. • Geothermal is most preferable source followed by Hydro, Wind, Biomass and Solar.

Effects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue.

Science.gov (United States)

Bozkaya, F; Atli, M O; Guzeloglu, A; Kayis, S A; Yildirim, M E; Kurar, E; Yilmaz, R; Aydilek, N

2017-08-01

The aim was to investigate the effects of long-term heat stress and dietary restriction on the expression of certain genes involving in steroidogenic pathway and small heat-shock proteins (sHSPs) in rat testis. Sprague Dawley rats (n = 24) were equally divided into four groups. Group I and II were kept at an ambient temperature of 22°C, while Groups III and IV were reared at 38°C for 9 weeks. Feed was freely available for Group I and Group III, while Group II and Group IV were fed 60% of the diet consumed by their ad libitum counterparts. At the end of 9 weeks, testicles were collected under euthanasia. Total RNA was isolated from testis tissue samples. Expression profiles of the genes encoding androgen-binding protein, follicle-stimulating hormone receptor, androgen receptor, luteinising hormone receptor, steroidogenic acute regulatory protein (StAR), cyclooxygenase-2 and sHSP genes were assessed at mRNA levels using qPCR. Long-term heat stress decreased the expression of StAR and HspB10 genes while dietary restriction upregulated StAR gene expression. The results suggested that long-term heat stress negatively affected the expression of StAR and HspB10 genes and the dietary restriction was able to reverse negative effect of heat stress on the expression of StAR gene in rat testis. © 2016 Blackwell Verlag GmbH.

Macro-economic and energy scenarios for Japan through the long-term

International Nuclear Information System (INIS)

Mankin, Shuichi

1986-03-01

As one of studies and systems analyses on the role of VHTR and process heat utilization in future energy systems, long-term macro economic and energy scenarios of Japan until the year 2030 have been generated. This paper presents,; 1) the outline of the long-term macro econometric model and the energy system dynamics model by which these scenarios were generated, 2) back grounds and prospects on future societies of Japan and exogeneous assumptions for calculations, and 3) macro energy and economic scenarios generated. Reflecting the present economic prospects, these scenarios are seemed to be of extremely low-growth type, however, the role of VHTR and its energy systems could be prospected clealy to play a large and important role within these scenario regions. Basic philosophies of scenario generations are also mentioned in this paper. (author)

13 CFR 107.850 - Restrictions on redemption of Equity Securities.

Science.gov (United States)

2010-01-01

... SMALL BUSINESS INVESTMENT COMPANIES Financing of Small Businesses by Licensees Structuring Licensee's Financing of An Eligible Small Business: Terms and Conditions of Financing § 107.850 Restrictions on... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Restrictions on redemption of...

Energy and climate policies of the USA during the two Barack Obama's terms

International Nuclear Information System (INIS)

Meritet, Sophie; Monjon, Stephanie

2016-02-01

As Barack Obama, from its first presidential campaign to its second term, supported the development of low carbon energies, the protection of climate and of the environment, the development of renewable energies, but also the development of non conventional fossil resources (during his second term), the authors first propose an analysis of the situation of the USA in terms of energy and of greenhouse gas emissions. They highlight the good situation of energy: USA are the first world producer, natural gas is being developed, coal is still present, and electric power is a centre of attention. The evolution of greenhouse gas emissions is discussed for the electricity sector and for the transport sector. In the next part, the authors discuss the content of the different policies implemented during both terms. These policies can be characterized by a strong support to renewable energies at the federal as well as state level, contrasted choices among states in terms of climate policy, federal initiatives for climate (reduction of CO_2 emissions in electric power plants, reduction of methane emissions, reduction of greenhouse gas emissions in other sectors), and actions on the international scene

The Long-Term Effects of Prematurity and Intrauterine Growth Restriction on Cardiovascular, Renal, and Metabolic Function

Directory of Open Access Journals (Sweden)

Patricia Y. L. Chan

2010-01-01

Full Text Available Objective. To determine relative influences of intrauterine growth restriction (IUGR and preterm birth on risks of cardiovascular, renal, or metabolic dysfunction in adolescent children. Study Design. Retrospective cohort study. 71 periadolescent children were classified into four groups: premature small for gestational age (SGA, premature appropriate for gestational age (AGA, term SGA, and term AGA. Outcome Measures. Systolic blood pressure (SBP, augmentation index (Al, glomerular filtration rate (GFR following protein load; plasma glucose and serum insulin levels. Results. SGA had higher SBP (average 4.6 mmHg and lower GFR following protein load (average 28.5 mL/min/1.73 m2 than AGA. There was no effect of prematurity on SBP (P=.4 or GFR (P=.9. Both prematurity and SGA were associated with higher AI (average 9.7% and higher serum insulin levels 2 hr after glucose load (average 15.5 mIU/L than all other groups. Conclusion. IUGR is a more significant risk factor than preterm birth for later systolic hypertension and renal dysfunction. Among children born preterm, those who are also SGA are at increased risk of arterial stiffness and metabolic dysfunction.

Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice

OpenAIRE

Park, Jong Hee; Ha, Hunjoo

2015-01-01

Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study ex...

Increased meal frequency does not promote greater weight loss in subjects who were prescribed an 8-week equi-energetic energy-restricted diet.

Science.gov (United States)

Cameron, Jameason D; Cyr, Marie-Josée; Doucet, Eric

2010-04-01

There have been reports of an inverse relationship between meal frequency (MF) and adiposity. It has been postulated that this may be explained by favourable effects of increased MF on appetite control and possibly on gut peptides as well. The main goal of the present study was to investigate whether using a high MF could lead to a greater weight loss than that obtained with a low MF under conditions of similar energy restriction. Subjects were randomised into two treatment arms (high MF = 3 meals+3 snacks/d or low MF = 3 meals/d) and subjected to the same dietary energy restriction of - 2931 kJ/d for 8 weeks. Sixteen obese adults (n 8 women and 8 men; age 34.6 (sd 9.5); BMI 37.1 (sd 4.5) kg/m2) completed the study. Overall, there was a 4.7 % decrease in body weight (P weight loss under the conditions described in the present study.

Analysis of recurrent neural networks for short-term energy load forecasting

Science.gov (United States)

Di Persio, Luca; Honchar, Oleksandr

2017-11-01

Short-term forecasts have recently gained an increasing attention because of the rise of competitive electricity markets. In fact, short-terms forecast of possible future loads turn out to be fundamental to build efficient energy management strategies as well as to avoid energy wastage. Such type of challenges are difficult to tackle both from a theoretical and applied point of view. Latter tasks require sophisticated methods to manage multidimensional time series related to stochastic phenomena which are often highly interconnected. In the present work we first review novel approaches to energy load forecasting based on recurrent neural network, focusing our attention on long/short term memory architectures (LSTMs). Such type of artificial neural networks have been widely applied to problems dealing with sequential data such it happens, e.g., in socio-economics settings, for text recognition purposes, concerning video signals, etc., always showing their effectiveness to model complex temporal data. Moreover, we consider different novel variations of basic LSTMs, such as sequence-to-sequence approach and bidirectional LSTMs, aiming at providing effective models for energy load data. Last but not least, we test all the described algorithms on real energy load data showing not only that deep recurrent networks can be successfully applied to energy load forecasting, but also that this approach can be extended to other problems based on time series prediction.

Explaining the contract terms of energy performance contracting in China: The importance of effective financing

International Nuclear Information System (INIS)

Li, Yan; Qiu, Yueming; Wang, Yi David

2014-01-01

Energy service company (“ESCO”) uses Energy Performance Contracting (“EPC”) to provide energy-saving services to its clients. Under an EPC, both ESCO and the client invest in the energy efficiency measures, according to a negotiated share of investment. Within the length of the contract, the ESCO and its client divide up the saved energy bill according to a negotiated share. Once the contract expires, the client claims all of the saved energy bills if the energy efficiency measures still last. Different EPC projects have different contract terms, including total investment, share of investment and length of contract. These contract terms directly determine the resulted energy savings. Thus it is essential and important to look at how these contract terms are formed and what are the major influencing factors. This paper first builds a theoretical bargain model between ESCO and its client to find out the structural relationship among these contract terms. Then, using the information of about 140 EPC contracts in China in 2010 and 2011, the paper empirically estimates the impacts of various factors on the contract terms and the resulted energy savings. We find that cost of capitals for ESCOs and the clients, especially for ESCOs, is a major factor influencing contract terms and the resulted energy savings. Thus providing effective financing is critical for the development of EPC in China. - Highlights: • We build a theoretical bargain model between an ESCO and its client. • We empirically quantify the impacts of various factors on EPC contract terms. • Cost of capital is a key factor determining EPC contract terms. • Providing effective financing, especially for ESCOs is important

Comparative assessment of different energy sources and their potential role in long-term sustainable energy mix

International Nuclear Information System (INIS)

Kagramanian, V.S.

2001-01-01

In the debate on sustainable energy future, the role of nuclear power is a contentious issue. Many, who are outside of the nuclear community, do not even consider nuclear, because of public concerns on nuclear safety, radioactive waste and non-proliferation issues. For example, the United Nations Development Program, in its document Energy After Rio does not suggest a specific role for nuclear power except in the most doubtful of terms. On the contrary, most nuclear organisations and related industries see nuclear power as the only mature carbon-free electricity generating option that can be deployed even on a much larger scale than today. This paper analyses the potential role of nuclear power in the context of the global sustainable energy future. The fundamental features of sustainable energy development are examined in terms of the following compatibility constraints: Demand driven compatibility; Natural resource compatibility; Environmental compatibility; Geopolitical compatibility; and Economic compatibility

Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study

Science.gov (United States)

Byrne, N M; Sainsbury, A; King, N A; Hills, A P; Wood, R E

2018-01-01

Background/Objectives: The MATADOR (Minimising Adaptive Thermogenesis And Deactivating Obesity Rebound) study examined whether intermittent energy restriction (ER) improved weight loss efficiency compared with continuous ER and, if so, whether intermittent ER attenuated compensatory responses associated with ER. Subjects/Methods: Fifty-one men with obesity were randomised to 16 weeks of either: (1) continuous (CON), or (2) intermittent (INT) ER completed as 8 × 2-week blocks of ER alternating with 7 × 2-week blocks of energy balance (30 weeks total). Forty-seven participants completed a 4-week baseline phase and commenced the intervention (CON: N=23, 39.4±6.8 years, 111.1±9.1 kg, 34.3±3.0 kg m−2; INT: N=24, 39.8±9.5 years, 110.2±13.8 kg, 34.1±4.0 kg m−2). During ER, energy intake was equivalent to 67% of weight maintenance requirements in both groups. Body weight, fat mass (FM), fat-free mass (FFM) and resting energy expenditure (REE) were measured throughout the study. Results: For the N=19 CON and N=17 INT who completed the intervention per protocol, weight loss was greater for INT (14.1±5.6 vs 9.1±2.9 kg; Penergy balance blocks was minimal (0.0±0.3 kg). While reduction in absolute REE did not differ between groups (INT: -502±481 vs CON: −624±557 kJ d−1; P=0.5), after adjusting for changes in body composition, it was significantly lower in INT (INT: −360±502 vs CON: −749±498 kJ d−1; Penergy balance ‘rest periods’ may reduce compensatory metabolic responses and, in turn, improve weight loss efficiency. PMID:28925405

Distinct cell stress responses induced by ATP restriction in quiescent human fibroblasts

Directory of Open Access Journals (Sweden)

Nirupama Yalamanchili

2016-10-01

Full Text Available Quiescence is the prevailing state of many cell types under homeostatic conditions. Yet, surprisingly little is known about how quiescent cells respond to energetic and metabolic challenges. To better understand compensatory responses of quiescent cells to metabolic stress, we established, in human primary dermal fibroblasts, an experimental ‘energy restriction’ model. Quiescence was achieved by short-term culture in serum-deprived media and ATP supply restricted using a combination of glucose transport inhibitors and mitochondrial uncouplers. In aggregate, these measures led to markedly reduced intracellular ATP levels while not compromising cell viability over the observation period of 48 h. Analysis of the transcription factor landscape induced by this treatment revealed alterations in several signal transduction nodes beyond the expected biosynthetic adaptations. These included increased abundance of NF-κB regulated transcription factors and altered transcription factor subsets regulated by Akt and p53. The observed changes in gene regulation and corresponding alterations in key signaling nodes are likely to contribute to cell survival at intracellular ATP concentrations substantially below those achieved by growth factor deprivation alone. This experimental model provides a benchmark for the investigation of cell survival pathways and related molecular targets that are associated with restricted energy supply associated with biological aging and metabolic diseases.

Medium-term energy hub management subject to electricity price and wind uncertainty

International Nuclear Information System (INIS)

Najafi, Arsalan; Falaghi, Hamid; Contreras, Javier; Ramezani, Maryam

2016-01-01

Highlights: • A new model for medium-term energy hub management is proposed. • Risk aversion is considered in medium-term energy hub management. • Stochastic programing is used to solve the medium-term energy hub management problem. • Electricity price and wind uncertainty are considered. - Abstract: Energy hubs play an important role in implementing multi-carrier energy systems. More studies are required in both their modeling and operating aspects. In this regard, this paper attempts to develop medium-term management of an energy hub in restructured power systems. A model is presented to manage an energy hub which has electrical energy and natural gas as inputs and electrical and heat energy as outputs. Electricity is procured in various ways, either purchasing it from a pool-based market and bilateral contracts, or producing it from a Combined Heat and Power (CHP) unit, a diesel generator unit and Wind Turbine Generators (WTGs). Pool prices and wind turbine production are subject to uncertainty, which makes energy management a complex puzzle. Heat demand is also procured by a furnace and a CHP unit. Energy hub managers should make decisions whether to purchase electricity from the electricity market and gas from the gas network or to produce electricity using a set of generators to meet the electrical and heat demands in the presence of uncertainties. The energy management objective is to minimize the total cost subject to several technical constraints using stochastic programming. Conditional Value at Risk (CVaR), a well-known risk measure, is used to reduce the unfavorable risk of costs. In doing so, the proposed model is illustrated using a sample test case with actual prices, load and wind speed data. The results show that the minimum cost is obtained by the best decisions involving the electricity market and purchasing natural gas for gas facilities. Considering risk also increases the total expected cost and decreases the CVaR.

Energy development and environment: What about solar energy in a long term perspective?

Science.gov (United States)

Dessus, Benjamin; Pharabod, Francois

After decades of strong growth, the next century might be that in which the world population is stabilized around 11 billion inhabitants. Next century's main concerns include the development hoped for the probable consequences of an increase of the greenhouse effect due to main induced emissions, and the risks posed by possible dissemination of nuclear energy to all the regions of the globe. In order to shed some light on these questions, we propose an energy scenario, based on an analysis of evolution of demographics, energy needs, renewable and fossil reserves, environmental issues, technological possibilities and regional imbalances. This scenario shows that solar energy could contribute significantly in the long term energy mix. We discuss the respective advantages and drawbacks of the different solar technologies: solar power satellites, ground solar power plants and decentralized applications, as they to the needs that must be satisfied.

Effects of 2-day calorie restriction on cardiovascular autonomic response, mood, and cognitive and motor functions in obese young adult women.

Science.gov (United States)

Solianik, Rima; Sujeta, Artūras; Čekanauskaitė, Agnė

2018-06-02

Although long-term energy restriction has been widely investigated and has consistently induced improvements in health and cognitive and motor functions, the responses to short-duration calorie restriction are not completely understood. The purpose of this study was to investigate the effects of a 2-day very low-calorie diet on evoked stress, mood, and cognitive and motor functions in obese women. Nine obese women (body fatness > 32%) aged 22-31 years were tested under two randomly allocated conditions: 2-day very low-calorie diet (511 kcal) and 2-day usual diet. The perceived stressfulness of the diet, cardiovascular autonomic response, and cognitive and motor performances were evaluated before and after each diet. The subjective stress rating of the calorie-restricted diet was 41.5 ± 23.3. Calorie restriction had no detectable effects on the heart rate variability indices, mood, grip strength, or psychomotor functions. By contrast, calorie restriction increased (p restriction evoked moderate stress in obese women, cardiovascular autonomic function was not affected. Calorie restriction had complex effects on cognition: it declined cognitive flexibility, and improved spatial processing and visuospatial working memory, but did not affect mood or motor behavior.

Left ventricular dimensions, systolic functions, and mass in term neonates with symmetric and asymmetric intrauterine growth restriction.

Science.gov (United States)

Cinar, Bahar; Sert, Ahmet; Gokmen, Zeynel; Aypar, Ebru; Aslan, Eyup; Odabas, Dursun

2015-02-01

Previous studies have demonstrated structural changes in the heart and cardiac dysfunction in foetuses with intrauterine growth restriction. There are no available data that evaluated left ventricular dimensions and mass in neonates with symmetric and asymmetric intrauterine growth restriction. Therefore, we aimed to evaluate left ventricular dimensions, systolic functions, and mass in neonates with symmetric and asymmetric intrauterine growth restriction. We also assessed associated maternal risk factors, and compared results with healthy appropriate for gestational age neonates. In all, 62 asymmetric intrauterine growth restriction neonates, 39 symmetric intrauterine growth restriction neonates, and 50 healthy appropriate for gestational age neonates were evaluated by transthoracic echocardiography. The asymmetric intrauterine growth restriction group had significantly lower left ventricular end-systolic and end-diastolic diameters and posterior wall diameter in systole and diastole than the control group. The symmetric intrauterine growth restriction group had significantly lower left ventricular end-diastolic diameter than the control group. All left ventricular dimensions were lower in the asymmetric intrauterine growth restriction neonates compared with symmetric intrauterine growth restriction neonates (p>0.05), but not statistically significant except left ventricular posterior wall diameter in diastole (3.08±0.83 mm versus 3.54 ±0.72 mm) (pintrauterine growth restriction groups had significantly lower relative posterior wall thickness (0.54±0.19 versus 0.48±0.13 versus 0.8±0.12), left ventricular mass (9.8±4.3 g versus 8.9±3.4 g versus 22.2±5.7 g), and left ventricular mass index (63.6±29.1 g/m2 versus 54.5±24.4 g/m2 versus 109±28.8 g/m2) when compared with the control group. Our study has demonstrated that although neonates with both symmetric and asymmetric intrauterine growth restriction had lower left ventricular dimensions, relative

An econometric study on long-term energy outlook and the implications of renewable energy utilization in Malaysia

International Nuclear Information System (INIS)

Gan, Peck Yean; Li, ZhiDong

2008-01-01

We developed a comprehensive econometric model to study the long-term outlook of Malaysia's economy, energy and environment to 2030. Our projections under the reference scenario indicated that Malaysia's gross domestic production (GDP) is expected to average 4.6% from 2004 to 2030, and total primary energy consumption will triple by 2030. Coal import will increase following governmental policy of intensifying its use for power generation. Oil import is predicted to take place by 2013 and reach 45 Mtoe in 2030. Hence, in the near future, Malaysia's energy import dependency will rise. Carbon emissions will triple by 2030. On the other hand, our projections under an alternative renewable energy (RE) scenario showed that the utilization of RE is a strategic option to improve the long-term energy security and environmental performance of Malaysia. However, substantial governmental involvements and support, as well as the establishment of a regulatory framework are necessary. (author)

Economically efficient energy generation and energy utilization: Potentials as well as effects in terms of energy, ecology, economy

International Nuclear Information System (INIS)

Masuhr, K.P.

1987-01-01

As the electric power industry is closely interlaced with the overall power supply system of the country, and especially with the heat market, a study into the impacts of an abandonment of nuclear power is necessary in order to be able to assess the situation in the energy sector at large. The report in hand summarizes the methodology adopted and the frame conditions taken as a basis. The contrast scenario without nuclear energy is explained and interpreted in terms of its effects on the energy market, the economy and the environment. (DG) [de

The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women.

Science.gov (United States)

Walhin, Jean-Philippe; Dixon, Natalie C; Betts, James A; Thompson, Dylan

2016-12-01

This study aimed to establish whether vigorous-intensity exercise offers additional adipose-related health benefits and metabolic improvements compared to energy-matched moderate-intensity exercise. Thirty-eight sedentary overweight men (n = 24) and postmenopausal women (n = 14) aged 52 ± 5 years (mean ± standard deviations [SD]) were prescribed a 3-week energy deficit (29302 kJ∙week -1 ) achieved by increased isocaloric moderate or vigorous-intensity exercise (+8372 kJ∙week -1 ) and simultaneous restricted energy intake (-20930 kJ∙week -1 ). Participants were randomly assigned to either an energy-matched vigorous (VIG; n = 18) or moderate (MOD; n = 20) intensity exercise group (five times per week at 70% or 50% maximal oxygen uptake, respectively). At baseline and follow-up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted. Body mass was reduced similarly in both groups (∆ 2.4 ± 1.1 kg and ∆ 2.4 ± 1.4 kg, respectively, P restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression. © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

The Effects of Calorie Restriction in Depression and Potential Mechanisms.

Science.gov (United States)

Zhang, Yifan; Liu, Changhong; Zhao, Yinghao; Zhang, Xingyi; Li, Bingjin; Cui, Ranji

2015-01-01

Depression, also called major depressive disorder, is a neuropsychiatric disorder jeopardizing an increasing number of the population worldwide. To date, a large number of studies have devoted great attention to this problematic condition and raised several hypotheses of depression. Based on these theories, many antidepressant drugs were developed for the treatment of depression. Yet, the depressed patients are often refractory to the antidepressant therapies. Recently, increasing experimental evidences demonstrated the effects of calorie restriction in neuroendocrine system and in depression. Both basic and clinical investigations indicated that short-term calorie restriction might induce an antidepressant efficacy in depression, providing a novel avenue for treatment. Molecular basis underlying the antidepressant actions of calorie restriction might involve multiple physiological processes, primarily including orexin signaling activation, increased CREB phosphorylation and neurotrophic effects, release of endorphin and ketone production. However, the effects of chronic calorie restriction were quite controversial, in the cases that it often resulted in the long-term detrimental effects via inhibiting the function of 5-HT system and decreasing leptin levels. Here we review such dual effects of calorie restriction in depression and potential molecular basis behind these effects, especially focusing on antidepressant effects.

Long-Term Energy Trends – Where Will We Be in 2050?

OpenAIRE

DIAZ-RAINEY, Ivan

2009-01-01

4TH ENERDAY CONFERENCE ON ENERGY ECONOMICS AND TECHNOLOGY, TU DRESDEN APRIL 3RD, 2009 The fourth gathering of the popular ENERDAY Conference was a one day event guided by the giddy-sounding theme of “LONG-TERM ENERGY TRENDS – WHERE WILL WE BE IN 2050?” The event attracted over 90 European experts in energy policy, energy technology and energy economics from academia, regulators, consultancies, and the energy industry itself. The event took place under the umbrella of TU Dres...

Long-term scenarios and strategies for the deployment of renewable energies in Germany

International Nuclear Information System (INIS)

Pregger, Thomas; Nitsch, Joachim; Naegler, Tobias

2013-01-01

The transformation of the energy supply in Germany (the “Energiewende”) as described in the German Federal government’s ‘Energy Concept’ (Energiekonzept, 2010) is based on a political consensus about long-term targets for energy efficiency and renewable energies. The aim of this article is to present a consistent scenario for this transformation process reflecting the long-term implementation of renewable energies and the possible future structure of the German energy system as a whole. Structural and economic effects of this development are derived and discussed. It summarizes results of scenario analyses done by the department of Systems Analysis and Technology Assessment of the German Aerospace Center as part of a three-year research project for the German Federal Ministry for the Environment. The underlying study provides a detailed data base reflecting a long-term roadmap for the energy system transformation in Germany. The scenarios show that the policy targets are consistent and can be achieved, if appropriate policy measures are to be implemented. The economic analysis shows the amount of investments and the strong market dynamics required for new generation technologies but also the huge economic benefits that can result from this development path in terms of fuel cost savings and lower fuel imports. - Highlights: • Long-term scenario for the German energy system according to the political targets. • Comparison of three variants with differing developments of the fleets of vehicles. • Analysis of economic effects: investments, generation and differential costs. • Importance of strategies in the sectors electricity, heat, and transportation. • Recommended measures for the successful implementation of the CO 2 reductions

Analysis on long-term perspectives of sustainable nuclear energy towards global warming protection

International Nuclear Information System (INIS)

Yamazawa, M.; Ichimura, E.; Shibata, Y.; Kobayashi, K.; Wajima, T.

1998-01-01

Study of long-term perspectives of the nuclear power generation was made from the point of views of both CO 2 emission constraints and sustainability of nuclear energy. To this end, STREAM (Semi-empirical TRiple E Analysis Model) program, as a social model, has been developed by Tokyo Electric Power Co. and Hitachi, Ltd. Using this program, long-term world demands of primary and nuclear energy were deduced, in view of the protection against the global warming due to the CO 2 gas accumulation. The inevitable conclusion has been drawn that nuclear energy plays an indispensable role in the reduction of green house effect. Evaluations were then made on conditions that the nuclear power system would be the long-term major sustainable energy source. (author)

Review: Neuroinflammation in intrauterine growth restriction.

Science.gov (United States)

Wixey, Julie A; Chand, Kirat K; Colditz, Paul B; Bjorkman, S Tracey

2017-06-01

Disruption to the maternal environment during pregnancy from events such as hypoxia, stress, toxins, inflammation, and reduced placental blood flow can affect fetal development. Intrauterine growth restriction (IUGR) is commonly caused by chronic placental insufficiency, interrupting supply of oxygen and nutrients to the fetus resulting in abnormal fetal growth. IUGR is a major cause of perinatal morbidity and mortality, occurring in approximately 5-10% of pregnancies. The fetal brain is particularly vulnerable in IUGR and there is an increased risk of long-term neurological disorders including cerebral palsy, epilepsy, learning difficulties, behavioural difficulties and psychiatric diagnoses. Few studies have focused on how growth restriction interferes with normal brain development in the IUGR neonate but recent studies in growth restricted animal models demonstrate increased neuroinflammation. This review describes the role of neuroinflammation in the progression of brain injury in growth restricted neonates. Identifying the mediators responsible for alterations in brain development in the IUGR infant is key to prevention and treatment of brain injury in these infants. Copyright © 2016 Elsevier Ltd. All rights reserved.

Exploitation of the Phebus inquiry. Better qualifying fuel poverty situations: coldness, heating restrictions, payment difficulties of energy bills, constrained limited mobility

International Nuclear Information System (INIS)

Ambrosio, Giulia; Belaid, Fateh; Bair, Sabrine; Teissier, Olivier

2015-01-01

The object of the research consists in estimating situations of fuel poverty from the statistical analysis of Phebus database 2012. The analysis of thermal characteristics of housing crossed with the uses by cutting down of heating, restriction of mobility and difficulties of payment of energy bills will allow us to anticipate better the phenomenon and to bring adapted answers

Long-term program on research, development and application of atomic energy

International Nuclear Information System (INIS)

2000-01-01

As the Committee of Atomic Energy in Japan has established eight times of the 'long-term basic program on development and application of atomic energy at every five years since 1956, these have consistently done every important roles as a leader of programmable promotion of policies on research, development and application of atomic energy in Japan. And, they also have showed some basic concepts on its research, development and application such as safety security, keeping of peaceful application, and so on, and also done a role as a strength with universality for promotion of their sure practices. Then, the Committee requested some surveys and discussions on establishment decided as a new long-term program on May, 1999, to a meeting on establishment of the long-term program, so as to clearly show a basic plan and its promoting measures on research, development and application of atomic energy to be adopted by Japan through the 21st Century under understanding of changes of various affairs after establishment of the previous program, to Japanese peoples, international society and nuclear relatives. The finished program is composed of two parts which are the first part of describing some messages toward Japanese peoples and society and international society and the second part of expressing concrete indications and promoting measures for practicing research, development and application of atomic energy. Here was shown on all sentences of the establishment containing the two parts of present condition and future way on research, development and application of atomic energy' and 'future evolution of research, development and application of atomic energy'. (G.K.)

10 CFR 2.911 - Admissibility of restricted data or other national security information.

Science.gov (United States)

2010-01-01

... security information. 2.911 Section 2.911 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR... Proceedings Involving Restricted Data and/or National Security Information § 2.911 Admissibility of restricted data or other national security information. A presiding officer shall not receive any Restricted Data...

10 CFR 95.25 - Protection of National Security Information and Restricted Data in storage.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Protection of National Security Information and Restricted Data in storage. 95.25 Section 95.25 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FACILITY SECURITY... Protection of National Security Information and Restricted Data in storage. (a) Secret matter, while...

An econometric study on long-term energy outlook and the implications of renewable energy utilization in Malaysia

Energy Technology Data Exchange (ETDEWEB)

Gan, Peck Yean [Department of Engineering-Energy and Environment Science, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, Niigata 940-2188 (Japan); Li, ZhiDong [Department of Management and Information System Science, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, Niigata 940-2188 (Japan)

2008-02-15

We developed a comprehensive econometric model to study the long-term outlook of Malaysia's economy, energy and environment to 2030. Our projections under the reference scenario indicated that Malaysia's gross domestic production (GDP) is expected to average 4.6% from 2004 to 2030, and total primary energy consumption will triple by 2030. Coal import will increase following governmental policy of intensifying its use for power generation. Oil import is predicted to take place by 2013 and reach 45 Mtoe in 2030. Hence, in the near future, Malaysia's energy import dependency will rise. Carbon emissions will triple by 2030. On the other hand, our projections under an alternative renewable energy (RE) scenario showed that the utilization of RE is a strategic option to improve the long-term energy security and environmental performance of Malaysia. However, substantial governmental involvements and support, as well as the establishment of a regulatory framework are necessary. (author)

A review of 'long-term energy supply and demand outlook'

International Nuclear Information System (INIS)

Hoshino, Yuko; Hamagata, Sumio; Nagata, Yutaka

2016-01-01

In this paper, we reviewed the 'Long-term Energy Supply and Demand Outlook' based on our original Japan's Economy and Energy Outlook toward 2030. 'The Long-term Energy Supply and Demand Outlook' was based on the following three basic policies: (1) Energy self-sufficiency rate in 2030 should be around 25 percent. (2) Electricity Costs in 2030 should be lower than the current level in 2013. (3) Emissions target of GHGs in 2030 should not be lower than that of EU and the US. Moreover, there were many assumptions or constraints, such as assumed economic growth rate consistent to the government's macro-economic policy and the share of renewable energy more than 20 percent. In order to satisfy the above mentioned conditions, an extraordinary energy saving should be implemented in the scenario. The assumed intensity of energy saving is as much as that after the two oil crises. We estimated the cost of that magnitude of energy saving based on our model simulation, which revealed that in order to achieve the energy saving target, the electricity price should be 80% higher than the business as usual case. In addition, we reviewed the long-term energy supply and demand scenarios of major developed countries such as the UK, the US, Italy, Germany and Australia. We found that most of the scenarios depend on a large scale of energy saving in order to achieve the GHG emissions reductions targets. The reality of those energy saving targets should be carefully re-examined under the low oil price environment. (author)

Real-time energy resources scheduling considering short-term and very short-term wind forecast

Energy Technology Data Exchange (ETDEWEB)

Silva, Marco; Sousa, Tiago; Morais, Hugo; Vale, Zita [Polytechnic of Porto (Portugal). GECAD - Knowledge Engineering and Decision Support Research Center

2012-07-01

This paper proposes an energy resources management methodology based on three distinct time horizons: day-ahead scheduling, hour-ahead scheduling, and real-time scheduling. In each scheduling process the update of generation and consumption operation and of the storage and electric vehicles storage status are used. Besides the new operation conditions, the most accurate forecast values of wind generation and of consumption using results of short-term and very short-term methods are used. A case study considering a distribution network with intensive use of distributed generation and electric vehicles is presented. (orig.)

Economical comparison of imported energy sources in terms of long-term production planning

International Nuclear Information System (INIS)

Gungor, Z.

1999-01-01

In this paper, the Turkish energy production sector is studied and power plants fueled by natural gas, imported coal and nuclear power are compared in terms of long-term (1996-2010) production economy. A net present value is used for comparing nuclear, coal and natural gas power plants. A scenario approach is utilized in establishing the effects of different factors, such as inflation rate, unit of investment costs, load factor change, discount rate and fuel price changes. Six different scenarios of interest are developed and discussed. The study ends with conclusions and recommendations based on a study of a reference scenario and alternative scenarios. (author)

Antimatter Requirements and Energy Costs for Near-Term Propulsion Applications

Science.gov (United States)

Schmidt, G. R.; Gerrish, H. P.; Martin, J. J.; Smith, G. A.; Meyer, K. J.

1999-01-01

The superior energy density of antimatter annihilation has often been pointed to as the ultimate source of energy for propulsion. However, the limited capacity and very low efficiency of present-day antiproton production methods suggest that antimatter may be too costly to consider for near-term propulsion applications. We address this issue by assessing the antimatter requirements for six different types of propulsion concepts, including two in which antiprotons are used to drive energy release from combined fission/fusion. These requirements are compared against the capacity of both the current antimatter production infrastructure and the improved capabilities that could exist within the early part of next century. Results show that although it may be impractical to consider systems that rely on antimatter as the sole source of propulsive energy, the requirements for propulsion based on antimatter-assisted fission/fusion do fall within projected near-term production capabilities. In fact, a new facility designed solely for antiproton production but based on existing technology could feasibly support interstellar precursor missions and omniplanetary spaceflight with antimatter costs ranging up to $6.4 million per mission.

Long-term functional outcomes and correlation with regional brain connectivity by MRI diffusion tractography metrics in a near-term rabbit model of intrauterine growth restriction.

Science.gov (United States)

Illa, Miriam; Eixarch, Elisenda; Batalle, Dafnis; Arbat-Plana, Ariadna; Muñoz-Moreno, Emma; Figueras, Francesc; Gratacos, Eduard

2013-01-01

Intrauterine growth restriction (IUGR) affects 5-10% of all newborns and is associated with increased risk of memory, attention and anxiety problems in late childhood and adolescence. The neurostructural correlates of long-term abnormal neurodevelopment associated with IUGR are unknown. Thus, the aim of this study was to provide a comprehensive description of the long-term functional and neurostructural correlates of abnormal neurodevelopment associated with IUGR in a near-term rabbit model (delivered at 30 days of gestation) and evaluate the development of quantitative imaging biomarkers of abnormal neurodevelopment based on diffusion magnetic resonance imaging (MRI) parameters and connectivity. At +70 postnatal days, 10 cases and 11 controls were functionally evaluated with the Open Field Behavioral Test which evaluates anxiety and attention and the Object Recognition Task that evaluates short-term memory and attention. Subsequently, brains were collected, fixed and a high resolution MRI was performed. Differences in diffusion parameters were analyzed by means of voxel-based and connectivity analysis measuring the number of fibers reconstructed within anxiety, attention and short-term memory networks over the total fibers. The results of the neurobehavioral and cognitive assessment showed a significant higher degree of anxiety, attention and memory problems in cases compared to controls in most of the variables explored. Voxel-based analysis (VBA) revealed significant differences between groups in multiple brain regions mainly in grey matter structures, whereas connectivity analysis demonstrated lower ratios of fibers within the networks in cases, reaching the statistical significance only in the left hemisphere for both networks. Finally, VBA and connectivity results were also correlated with functional outcome. The rabbit model used reproduced long-term functional impairments and their neurostructural correlates of abnormal neurodevelopment associated with IUGR

26 CFR 25.2703-1 - Property subject to restrictive arrangements.

Science.gov (United States)

2010-04-01

... shareholders' agreement, or any other agreement. A right or restriction may be implicit in the capital structure of an entity. (4) Qualified easements. A perpetual restriction on the use of real property that..., whether or not authorized by the terms of the agreement, that results in other than a de minimis change to...

The rank of nuclear technology in terms of economic policy and energy policy

International Nuclear Information System (INIS)

Engelmann, U.

1984-01-01

Once the nuclear power plants presently under construction are completed, the exisiting basic load deficit will be done with, except for regional peculiarities. The need for redeployment of the power plant pool caused by the 1973/74 energy crisis is then virtually exhausted in terms of basic load. Taking into consideration the special role of black coal in power production, further nuclear power plants will be necessary in the Federal Republic of Germany mainly if the power demand increases and/or to replace decommissioned plants. The role of nuclear technology is not restricted to the domestic demand; particularly in threshold countries the market can provide some compensation. Nuclear technology is a factor of economic policy; the Federal Government points this out in its negotiations with foreign countries. However, it is noteworthy that the third biggest political party in the Federal Republic of Germany want to stop all presently existing nuclear power plants. The best rebuttal of such political debate is properly operating nuclear plants and the steadily growing percentage of electricity they produce as well as lower electricity price in those Lander of the Federal Republic of Germany who did not put on ideological blinkers in face of nuclear technology. (orig./HSCH) [de

Long-term cost targets for nuclear energy

International Nuclear Information System (INIS)

Rogner, H.H.; McDonald, A.

2004-01-01

In 2000 the International Atomic Energy Agency (IAEA) began the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) to help guide nuclear R and D strategies targeted on anticipated mid-century energy system needs. One part of INPRO seeks to develop cost targets for new designs to be competitive in mid-century markets. The starting point was the 40 scenarios of the Special Report on Emissions Scenarios (SRES) of the Intergovernmental Panel on Climate Change. This paper summarizes four of the SRES scenarios, one from each of the four SRES scenario families. It discusses their implications for nuclear energy, including cost targets, and develops for each an 'aggressive nuclear' variant. The aggressive nuclear variants estimate the potential market for nuclear energy if, by improving faster than assumed by the SRES authors, nuclear energy can make inroads into vulnerable market shares projected for its competitors. In addition to projected demands for nuclear generated electricity, hydrogen and heat, the aggressive variants include prospective demand for nuclear desalination and use in upgrading fossil fuels. The paper then presents learning rates and implied cost targets consistent with the aggressive nuclear variants of the SRES scenarios. One provocative initial result is that many of the scenarios with substantial nuclear expansion do not seem to require big reductions in nuclear investment costs. One interpretation discussed at the end of the paper highlights the difference between cost reductions consistent with long-term energy system optimization based on perfect foresight, and cost reductions necessary to attract private investment in today's 'deregulating' and uncertain energy markets. (orig.)

US long-term energy intensity: Backcast and projection

International Nuclear Information System (INIS)

Dowlatabadi, Hadi; Oravetz, Matthew A.

2006-01-01

Energy intensity of the economy is often modeled as being determined by the combined effect of a fixed price elasticity of demand, and an exogenously specified, fixed technical change parameter denoted as the autonomous energy efficiency improvement (AEEI). Typically, the AEEI rate is set to 0.5-1.5% improvement per annum. Here, we study historic aggregate energy intensity trends for the US from 1954 to 1994. We show that the historic trends are inconsistent with an autonomous model of improved energy efficiency-especially when the model is used to inform policies that impact energy prices. As an alternative we propose a model of price-induced efficiency, π, in which aggregate energy intensity trends respond to changes in energy prices beyond price elasticity of demand ε. Our exercise reveals that the aggregate price elasticity of energy demand of the US economy has declined by roughly 15% over the past four decades. But beyond this decline, bringing our simulations and historical data into close correspondence requires π to change sign before and after 1974. Before 1974, after accounting for price elasticity of demand, the economy was growing less energy efficient. After 1974, after accounting for the price elasticity of demand, the economy was growing more energy efficient. Furthermore, since 1984, the rate of energy efficiency gain has been declining. When projections of long-term energy use are compared, those with a price-induced energy efficiency formulation generate significantly more price sensitive energy use and emissions trajectories. When in the business as usual scenario energy prices are expected to be rising, climate policies involve lower shadow carbon prices with π than with AEEI formulations. In scenarios where energy prices are relatively flat, energy intensity rises leading to CO 2 emissions far higher than standard business as usual projections utilizing AEEI assumptions

US long-term energy intensity: backcast and projection

International Nuclear Information System (INIS)

Dowlatabadi, H.; Oravetz, M.A.

2006-01-01

Energy intensity of the economy is often modeled as being determined by the combined effect of a fixed price elasticity of demand, and an exogenously specified, fixed technical change parameter denoted as the autonomous energy efficiency improvement (AEEI). Typically, the AEEI rate is set to 0.5-1.5% improvement per annum. Here, we study historic aggregate energy intensity trends for the US from 1954 to 1994. We show that the historic trends are inconsistent with an autonomous model of improved energy efficiency - especially when the model is used to inform policies that impact energy prices. As an alternative we propose a model of price-induced efficiency, π, in which aggregate energy intensity trends respond to changes in energy prices beyond price elasticity of demandε. Our exercise reveals that the aggregate price elasticity of energy demand of the US economy has declined by roughly 15% over the past four decades. But beyond this decline, bringing our simulations and historical data into close correspondence requires π to change sign before and after 1974. Before 1974, after accounting for price elasticity of demand, the economy was growing less energy efficient. After 1974, after accounting for the price elasticity of demand, the economy was growing more energy efficient. Furthermore, since 1984, the rate of energy efficiency gain has been declining. When projections of long-term energy use are compared, those with a price-induced energy efficiency formulation generate significantly more price sensitive energy use and emissions trajectories. When in the business as usual scenario energy prices are expected to be rising, climate policies involve lower shadow carbon prices with π than with AEEI formulations. In scenarios where energy prices are relatively flat, energy intensity rises leading to CO 2 emissions far higher than standard business as usual projections utilizing AEEI assumptions. (Author)

US long-term energy intensity: backcast and projection

Energy Technology Data Exchange (ETDEWEB)

Dowlatabadi, H. [University of British Columbia, Vancouver (Canada); Oravetz, M.A. [International Energy Agency, Paris (France)

2006-11-15

Energy intensity of the economy is often modeled as being determined by the combined effect of a fixed price elasticity of demand, and an exogenously specified, fixed technical change parameter denoted as the autonomous energy efficiency improvement (AEEI). Typically, the AEEI rate is set to 0.5-1.5% improvement per annum. Here, we study historic aggregate energy intensity trends for the US from 1954 to 1994. We show that the historic trends are inconsistent with an autonomous model of improved energy efficiency - especially when the model is used to inform policies that impact energy prices. As an alternative we propose a model of price-induced efficiency, {pi}, in which aggregate energy intensity trends respond to changes in energy prices beyond price elasticity of demand{epsilon}. Our exercise reveals that the aggregate price elasticity of energy demand of the US economy has declined by roughly 15% over the past four decades. But beyond this decline, bringing our simulations and historical data into close correspondence requires {pi} to change sign before and after 1974. Before 1974, after accounting for price elasticity of demand, the economy was growing less energy efficient. After 1974, after accounting for the price elasticity of demand, the economy was growing more energy efficient. Furthermore, since 1984, the rate of energy efficiency gain has been declining. When projections of long-term energy use are compared, those with a price-induced energy efficiency formulation generate significantly more price sensitive energy use and emissions trajectories. When in the business as usual scenario energy prices are expected to be rising, climate policies involve lower shadow carbon prices with {pi} than with AEEI formulations. In scenarios where energy prices are relatively flat, energy intensity rises leading to CO{sub 2} emissions far higher than standard business as usual projections utilizing AEEI assumptions. (Author)

Short-term effects of maternal feed restriction during pregnancy on goat kid morphology, metabolism, and behavior

OpenAIRE

Laporte-Broux, Bérengère; Roussel, Sabine; Ponter, Andrew; Perault, Julien; Chavatte-Palmer, Pascale; Duvaux-Ponter, Christine

2011-01-01

Morphometric, metabolic, and behavioural modifications were studied in goat kids after maternal feed restriction during the last one-third of pregnancy. At birth, only kids from twin and triplet litters were studied [n = 40 kids born to control dams (CONT) and n = 38 born to restricted dams (REST)] and only males thereafter (n = 13 CONT and 15 REST kids) until slaughter at 6 wk of age. Kids born to restricted goats had a smaller abdominal girth at birth P < 0.01) and tended to have a smaller ...

Structural change of the economy, technological progress and long-term energy demand

International Nuclear Information System (INIS)

Klinge Jacobsen, H.

2000-01-01

The material included in the report is a collection of papers dealing with different issues related to the topics included in the title. Some of these papers have already either been published or presented at various conferences. Together with a general introduction, they constitute the author's PhD dissertation. The dissertation includes six papers and two shorter notes on different aspects of structural change of the economy and energy demand. Three different issues related to long-term energy demand are discussed: (1) the importance of technological change and its representation in energy-economy modelling, (2) an integration of two different modelling approaches, and (3) the effect on energy demand of structural changes exemplified by changes in the energy supply sector and in Danish trade patterns. The report highlights a few aspects of the interaction between structural economic changes and energy demand, but it does not intend to cover a wide range of issues related to these topics. In the introductory chapter some discussions and thoughts about issues not covered by the articles are brought forward. The introductory chapter includes an overview of possible relations between longterm energy demand and the economy, technical progress demography, social conditions and politics. The first two papers discuss the importance for projections of long-term energy demand of the way in which technological progress is modelled. These papers focus on energy-economy modelling. A paper dealing with two different approaches to energy demand modelling and the possible integration of these approaches in the Danish case follows next. The integrated Danish model, is then used for analysing different revenue recycling principles in relation to a CO 2 tax. The effect of subsidising biomass use is compared with recycling through corporate tax rates. Then a paper follows describing the structural change of a specific sector, namely the energy supply sector, and the implications for

Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet.

Science.gov (United States)

Ibero-Baraibar, Idoia; Suárez, Manuel; Arola-Arnal, Anna; Zulet, M Angeles; Martinez, J Alfredo

2016-01-01

Cardiometabolic profile is usually altered in obesity. Interestingly, the consumption of flavanol-rich foods might be protective against those metabolic alterations. To evaluate the postprandial cardiometabolic effects after the acute consumption of cocoa extract before and after 4 weeks of its daily intake. Furthermore, the bioavailability of cocoa extract was investigated. Twenty-four overweight/obese middle-aged subjects participated in a 4-week intervention study. Half of the volunteers consumed a test meal enriched with 1.4 g of cocoa extract (415 mg flavanols), while the rest of the volunteers consumed the same meal without the cocoa extract (control group). Glucose and lipid profile, as well as blood pressure and cocoa metabolites in plasma, were assessed before and at 60, 120, and 180 min post-consumption, at the beginning of the study (Postprandial 1) and after following a 4-week 15% energy-restricted diet including meals containing or not containing the cocoa extract (Postprandial 2). In the Postprandial 1 test, the area under the curve (AUC) of systolic blood pressure (SBP) was significantly higher in the cocoa group compared with the control group (p=0.007), showing significant differences after 120 min of intake. However, no differences between groups were observed at Postprandial 2. Interestingly, the reduction of postprandial AUC of SBP (AUC_Postprandial 2-AUC_Postprandial 1) was higher in the cocoa group (p=0.016). Furthermore, cocoa-derived metabolites were detected in plasma of the cocoa group, while the absence or significantly lower amounts of metabolites were found in the control group. The daily consumption of cocoa extract within an energy-restricted diet for 4 weeks resulted in a greater reduction of postprandial AUC of SBP compared with the effect of energy-restricted diet alone and independently of body weight loss. These results suggest the role of cocoa flavanols on postprandial blood pressure homeostasis.

Fusion energy in context: its fitness for the long term

International Nuclear Information System (INIS)

Holdren, J.P.

1978-01-01

Long-term limits to growth in energy will be imposed not by inability to expand supply, but by the rising environmental and social costs of doing so. These costs will therefore be cental issues in choosing long-term options. Fusion, like solar energy, is not one possibility but many, some with very attractive environmental characteristics and others perhaps little better in these regards than fission. None of the fusion options will be cheap, and none is likely to be widely available before the year 2010. The most attractive forms of fusion may require greater investments of time and money to achieve, but they are the real reason for wanting fusion at all

Restrictive Cardiomyopathy Associated With Long-Term Use of Hydroxychloroquine for Systemic Lupus Erythematosus.

Science.gov (United States)

Sabato, Leah A; Mendes, Lisa A; Cox, Zachary L

2017-10-01

Hydroxychloroquine (HQ) is commonly prescribed for autoimmune diseases such as systemic lupus erythematosus. We report a case of a 75-year-old female presenting with de novo decompensated heart failure and restrictive cardiomyopathy (left ventricular ejection fraction: 40%-45%) after treatment with HQ for more than 11 years. Hydroxychloroquine was discontinued, and follow-up echocardiogram 57 days after discontinuation showed normalization of her left ventricular ejection fraction. A score of 7 on the Naranjo Adverse Drug Reaction Probability Scale indicates that HQ is a probable cause of this patient's cardiomyopathy. An adverse drug effect due to HQ should be considered in treated patients who present with restrictive cardiomyopathy. Discontinuation may allow for partial or complete reversal of the cardiomyopathy.

Newer antidiabetic drugs and calorie restriction mimicry

Directory of Open Access Journals (Sweden)

Sanjay Kalra

2016-01-01

Full Text Available De-acceleration of aging and delayed development of age-related morbidity accompanies the restriction of calories (without malnutrition in laboratory mice, nematodes, yeast, fish, and dogs. Recent results from long-term longitudinal studies conducted on primates have suggested longevity benefits of a 30% restriction of calories in rhesus monkeys as well. Among calorie restricted rhesus monkeys one of the mechanisms for the improvement in lifespan was the reduction in the development of glucose intolerance and cardiovascular disease. Although there are no comparable human studies, it is likely that metabolic and longevity benefits will accompany a reduction in calories in humans as well. However, considering the difficulties in getting healthy adults to limit food intake science has focused on understanding the biochemical processes that accompany calorie restriction (CR to formulate drugs that would mimic the effects of CR without the need to actually restrict calories. Drugs in this emerging therapeutic field are called CR mimetics. Some of the currently used anti-diabetic agents may have some CR mimetic like effects. This review focuses on the CR mimetic properties of the currently available anti-diabetic agents.

Is two days of intermittent energy restriction per week a feasible weight loss approach in obese males? A randomised pilot study.

Science.gov (United States)

Conley, Marguerite; Le Fevre, Lauren; Haywood, Cilla; Proietto, Joseph

2018-02-01

The 5:2 diet (two non-consecutive days of 2460 KJ (600 calories) and 5 days of ad libitum eating per week) is becoming increasingly popular. This pilot study aimed to determine whether the 5:2 diet can achieve ≥5% weight loss and greater improvements in weight and biochemical markers than a standard energy-restricted diet (SERD) in obese male war veterans. A total of 24 participants were randomised to consume either the 5:2 diet or a SERD (2050 KJ (500 calorie) reduction per day) for 6 months. Weight, waist circumference (WC), fasting blood glucose, blood lipids, blood pressure and dietary intake were measured at baseline, 3 and 6 months by a blinded investigator. After 6 months, participants in both groups significantly reduced body weight (P = fasting blood glucose or blood lipids in either dietary group. Results suggest that the 5:2 diet is a successful but not superior weight loss approach in male war veterans when compared to a SERD. Future research is needed to determine the long-term effectiveness of the 5:2 diet and its effectiveness in other population groups. © 2017 Dietitians Association of Australia.

The influence of food restriction on the small bowel: Does intensive short‑term food restriction lead to weight loss?

Czech Academy of Sciences Publication Activity Database

Makovický, Peter; Tůmová, E.; Volek, Z.; Makovický, P.; Arnone, J.M.; Švecová, Ivana; Samasca, G.

2017-01-01

Roč. 118, č. 6 (2017), s. 361-365 ISSN 0006-9248 R&D Projects: GA MŠk(CZ) LM2015040; GA MŠk(CZ) ED1.1.00/02.0109 Institutional support: RVO:68378050 Keywords : experimental medicine * food restriction * rabbit * slimming * small bowel weight loss Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Pathology Impact factor: 0.667, year: 2016

The relationship between energy intensity and income levels: Forecasting long term energy demand in Asian emerging countries

International Nuclear Information System (INIS)

Galli, R.; Univ. della Svizzera Italiana, Lugano

1998-01-01

This paper analyzes long-term trends in energy intensity for ten Asian emerging countries to test for a non-monotonic relationship between energy intensity and income in the author's sample. Energy demand functions are estimated during 1973--1990 using a quadratic function of log income. The long-run coefficient on squared income is found to be negative and significant, indicating a change in trend of energy intensity. The estimates are then used to evaluate a medium-term forecast of energy demand in the Asian countries, using both a log-linear and a quadratic model. It is found that in medium to high income countries the quadratic model performs better than the log-linear, with an average error of 9% against 43% in 1995. For the region as a whole, the quadratic model appears more adequate with a forecast error of 16% against 28% in 1995. These results are consistent with a process of dematerialization, which occurs as a result of a reduction of resource use per unit of GDP once an economy passes some threshold level of GDP per capita

Closing the gap between short- and long-term scenarios for nuclear energy

International Nuclear Information System (INIS)

Toth, F. L.; Rogner, H.-H.

2005-01-01

Many scenarios published in recent years explore the driving forces and assess plausible ranges of global energy use and the resources they draw on. Some scenarios (e.g., OECD IEA, Organization for Economic Co-operation and Development International Energy Agency, 2004) focus on the next decade or two and project the evolution of world energy demand, supply as well as the resources, technologies, and prices to match them. Other scenarios (e.g., the Special Report on Emissions Scenarios, SRES, prepared by the Intergovernmental Panel on Climate Change, IPCC, 2000) explore the long term with a view to resource availability and depletion, technological transformations, and environmental concerns, predominantly climate change. A persistent gap (see Figure 1) can be observed in the projections for nuclear energy: near-term scenarios typically project a flat or slightly declining contribution of nuclear energy to the world energy supply whereas medium- and long-term scenarios anticipate significant increases. The magnitude of the gap between the OECD IEA (2002) projections and the median of the 40 IPCC SRES scenarios for the year 2020 amounts to almost 300 GWe installed capacity. Reasons for the gap originate in the differences between the analytical frameworks (including projection techniques) adopted by the short- and long-term studies. Another, closely related reason is the difference in the underlying assumptions, particularly their relations to recent trends and the current situation. In addition, near-term projections are heavily influenced by the social context (perceived unpopularity or outright rejection of nuclear power after Chernobyl), political factors (government pronouncements and policies at the national level, diplomacy and balancing of national positions at international organizations), economic aspects (energy market deregulation and liberalization unveiling excess capacities; financial risks), technology matters (the role of learning, definition of

Whole Grain Compared with Refined Wheat Decreases the Percentage of Body Fat Following a 12-Week, Energy-Restricted Dietary Intervention in Postmenopausal Women

DEFF Research Database (Denmark)

Kristensen, Mette; Toubro, Søren; Jensen, Morten Georg

2012-01-01

) with whole-grain wheat (WW) for 12 wk on body weight and composition after a 2-wk run-in period of consumption of RW-containing food intake. In this open-label randomized trial, 79 overweight or obese postmenopausal women were randomized to an energy-restricted diet (deficit of approximately 1250 k...

The uranium industry: long-term planning for short-term competition

International Nuclear Information System (INIS)

Vottero, X.; Georges Capus, G.

2001-01-01

Long term planning for short term competition Today, uranium producers face new challenges in terms of both production (new regulatory, environmental and social constraints) and market conditions (new sources of uranium supply, very low prices and tough competition). In such a context, long-term planning is not just a prerequisite to survive in the nuclear fuel cycle industry. In fact, it also contributes to sustaining nuclear electricity generation facing fierce competition from other energy sources in increasingly deregulated markets. Firstly, the risk of investing in new mining projects in western countries is growing because, on the one hand, of very erratic market conditions and, on the other hand, of increasingly lengthy, complex and unpredictable regulatory conditions. Secondly, the supply of other sources of uranium (uranium derived from nuclear weapons, uranium produced in CIS countries, ...) involve other risks, mainly related to politics and commercial restrictions. Consequently, competitive uranium supply requires not only technical competence but also financial strength and good marketing capabilities in order to anticipate long-term market trends, in terms of both demand and supply. It also requires taking into account new parameters such as politics, environment, regulations, etc. Today, a supplier dedicated to the sustainable production of nuclear electricity must manage a broad range of long-term risks inherent to the procurement of uranium. Taking into account all these parameters in a context of short-term, fast-changing market is a great challenge for the future generation. World Uranium Civilian Supply and Demand. (authors)

Reducing milking frequency during nutrient restriction has no effect on the hepatic transcriptome of lactating dairy cattle.

Science.gov (United States)

Grala, T M; Kay, J K; Phyn, C V C; Bionaz, M; Walker, C G; Rius, A G; Snell, R G; Roche, J R

2013-12-01

The objective of this study was to investigate if a reduced milking frequency altered the effect of dietary energy restriction on the hepatic transcriptome of grazing dairy cows during early lactation. Multiparous Holstein-Friesian and Holstein-Friesian × Jersey cows (n = 120) were milked twice daily (2×) from calving until 34 ± 6 days in milk (mean ± SD). Cows were then allocated to one of four treatments in a 2 × 2 factorial arrangement. Treatments consisted of two milking frequencies [2× or once daily (1×)] and two feeding levels for 3 wk: adequately fed (AF) or underfed (UF, 60% of AF). Liver tissue was biopsied from 12 cows per treatment after 3 wk of treatment, and the hepatic transcriptome was profiled with an Agilent 4 × 44k bovine microarray. Over 2,900 genes were differentially expressed in response to the energy restriction; however, no effects resulted from changes to milking frequency. This may indicate that after 3 wk of 1× milking, any changes to the liver transcriptome that may have occurred earlier have returned to normal. After 3 wk of energy restriction, gene expression patterns indicate that glucose-sparing pathways were activated, and gluconeogenesis was increased in UF cows. Genes involved in hepatic stress were upregulated in response to the energy restriction indicative of the pressure energy restriction places on liver function. Other pathways upregulated included "cytoskeletal remodeling," indicating that a 3 wk energy restriction resulted in molecular changes to assist tissue remodeling. Overall, 1× milking does not modify the hepatic transcriptome changes that occur in response to an energy restriction.

Group Home Energy Efficiency Retrofit for 30% Energy Savings: Washington, D.C. (Fact Sheet)

Energy Technology Data Exchange (ETDEWEB)

None, None

2013-11-01

Energy efficiency retrofits (EERs) face many challenges on the path to scalability. Limited budgets, cost effectiveness, risk factors, and accessibility impact the type and the extent of measures that can be implemented feasibly to achieve energy savings goals. Group home retrofits can face additional challenges than those in single family homes - such as reduced access (occupant-in-place restrictions) and lack of incentives for occupant behavioral change. This project studies the specification, implementation, and energy savings from an EER in a group home, with an energy savings goal of 30%. This short term test report chronicles the retrofit measures specified, their projected cost-effectiveness using building energy simulations, and the short term test results that were used to characterize pre-retrofit and post-retrofit conditions. Additionally, the final report for the project will include analysis of pre- and post-retrofit performance data on whole building energy use, and an assessment of the energy impact of occupant interface with the building (i.e., window operation). Ultimately, the study's results will be used to identify cost effective EER measures that can be implemented in group homes, given constraints that are characteristic of these buildings. Results will also point towards opportunities for future energy savings.

Variable Renewable Energy in Long-Term Planning Models: A Multi-Model Perspective

Energy Technology Data Exchange (ETDEWEB)

Cole, Wesley [National Renewable Energy Lab. (NREL), Golden, CO (United States); Frew, Bethany [National Renewable Energy Lab. (NREL), Golden, CO (United States); Mai, Trieu [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sun, Yinong [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bistline, John [Electric Power Research Inst. (EPRI), Knoxville, TN (United States); Blanford, Geoffrey [Electric Power Research Inst. (EPRI), Knoxville, TN (United States); Young, David [Electric Power Research Inst. (EPRI), Knoxville, TN (United States); Marcy, Cara [U.S. Energy Information Administration, Washington, DC (United States); Namovicz, Chris [U.S. Energy Information Administration, Washington, DC (United States); Edelman, Risa [US Environmental Protection Agency (EPA), Washington, DC (United States); Meroney, Bill [US Environmental Protection Agency (EPA), Washington, DC (United States); Sims, Ryan [US Environmental Protection Agency (EPA), Washington, DC (United States); Stenhouse, Jeb [US Environmental Protection Agency (EPA), Washington, DC (United States); Donohoo-Vallett, Paul [Dept. of Energy (DOE), Washington DC (United States)

2017-11-01

Long-term capacity expansion models of the U.S. electricity sector have long been used to inform electric sector stakeholders and decision-makers. With the recent surge in variable renewable energy (VRE) generators — primarily wind and solar photovoltaics — the need to appropriately represent VRE generators in these long-term models has increased. VRE generators are especially difficult to represent for a variety of reasons, including their variability, uncertainty, and spatial diversity. This report summarizes the analyses and model experiments that were conducted as part of two workshops on modeling VRE for national-scale capacity expansion models. It discusses the various methods for treating VRE among four modeling teams from the Electric Power Research Institute (EPRI), the U.S. Energy Information Administration (EIA), the U.S. Environmental Protection Agency (EPA), and the National Renewable Energy Laboratory (NREL). The report reviews the findings from the two workshops and emphasizes the areas where there is still need for additional research and development on analysis tools to incorporate VRE into long-term planning and decision-making. This research is intended to inform the energy modeling community on the modeling of variable renewable resources, and is not intended to advocate for or against any particular energy technologies, resources, or policies.

Dietary sodium restriction: a neglected therapeutic opportunity in chronic kidney disease

Science.gov (United States)

Humalda, Jelmer K.; Navis, Gerjan

2014-01-01

Purpose of review Restriction of dietary sodium is recommended at a population level as well as for groups at high cardiovascular risk, and chronic kidney disease (CKD). This review addresses recent evidence for the protective effect of dietary sodium restriction in CKD patients specifically. Recent findings Sodium intake in CKD populations is generally high, and often above population average. Recent data demonstrated that moderately lower sodium intake in CKD patients is associated with substantially better long-term outcome of renin–angiotensin–aldosterone system (RAAS)-blockade, in diabetic and nondiabetic CKD, related to better effects of RAAS-blockade on proteinuria, independent of blood pressure. This is in line with better short-term efficacy of RAAS-blockade during moderate sodium restriction in diabetic and nondiabetic CKD. This effect of sodium restriction is likely mediated by its effects on volume status. Sustainable sodium restriction can be achieved by approaches on the basis of behavioral sciences. Summary Moderate restriction of dietary sodium can substantially improve the protective effects of RAAS-blockade in CKD, by specific renal effects apparent from proteinuria reduction. The latter precludes straightforward extrapolation of data from nonrenal populations to CKD. Concerns regarding the adverse effects of a very low sodium intake should not distract from the protective effects of moderate sodium restriction. Prospective studies should assess the efficacy and sustainability of different strategies to target high sodium intake in CKD, along with measures at population level. Video abstract http://links.lww.com/CONH/A14 PMID:25222815

Energy consumption restricted productivity re-estimates and industrial sustainability analysis in post-reform China

International Nuclear Information System (INIS)

Chen, Shiyi; Santos-Paulino, Amelia U.

2013-01-01

This paper investigates the impact of energy on China's industrial sustainability by using a novel approach to estimate real total factor productivity. The growth accounting indicates that the substantial industrial reforms in China have led to productivity growth. Energy and capital are also important factors driving China's industrial growth. Productivity growth in China's industry is mostly attributable to the high-tech light industrial sectors. - Highlights: ► Productivity has become the most important growth engine in majority of sectors. ► Energy and capital are also important factors promoting China's industrial growth. ► The productivity improvement is more attributable to high-tech light industry. ► The heavy industry performs worse than the light one in terms of productivity

A comparison of low-carbohydrate vs. high-carbohydrate diets: energy restriction, nutrient quality and correlation to body mass index.

Science.gov (United States)

Bowman, Shanthy A; Spence, Joseph T

2002-06-01

To evaluate free-living adults' diets that ranged from very low to high amounts of carbohydrate for their energy content, nutritional quality and correlation to Body Mass Index. Adults ages 19 years and older, who had complete dietary intake data on day-1 of the USDA's 1994 to 1996 Continuing Survey of Food Intakes by Individuals (CSFII 1994-1996), were divided into four groups--very low, low, moderate and high carbohydrate--based on the percent total energy from carbohydrate. Mean energy, nutrient, food intakes and Body Mass Index values were compared among the groups. SUDAAN software package was used for the data analysis and pair-wise mean comparisons (p low-fat foods, grain products and fruits. This group also had the lowest sodium intake. Adults eating a high-carbohydrate diet are more likely to have Body Mass Index values below 25. A study of diets of free-living adults in the U.S. showed that diets high in carbohydrate were both energy restrictive and nutritious and may be adopted for successful weight management.

Fasting leptin and appetite responses induced by a 4-day 65%-energy-restricted diet

NARCIS (Netherlands)

Mars, M.; Graaf, de C.; Groot, de C.P.G.M.; Rossum, van C.T.M.; Kok, F.J.

2006-01-01

Objective: Animal studies show that the leptin decline after acute severe caloric restriction is a peripheral signal to increase food intake. However, most human studies have failed to observe such a relationship. We studied the acute effects of severe caloric restriction on the association between

Fasting leptin and appetite responses induced by a 4-day 65%-energy-restricted diet.

NARCIS (Netherlands)

Mars, M; Graaf, C de; Groot, C P G M de; Rossum, Caroline T M van; Kok, F J

2006-01-01

OBJECTIVE: Animal studies show that the leptin decline after acute severe caloric restriction is a peripheral signal to increase food intake. However, most human studies have failed to observe such a relationship. We studied the acute effects of severe caloric restriction on the association between

China's building energy demand: Long-term implications from a detailed assessment

International Nuclear Information System (INIS)

Eom, Jiyong; Clarke, Leon; Kim, Son H.; Kyle, Page; Patel, Pralit

2012-01-01

Buildings are an important contributor to China's energy consumption and attendant CO 2 emissions. Measures to address energy consumption and associated emissions from the buildings sector will be an important part of strategy to reduce the country's CO 2 emissions. This study presents a detailed, service-based model of China's building energy demand, nested in the GCAM (Global Change Assessment Model) integrated assessment framework. Using the model, we explored long-term pathways of China's building energy demand and identified opportunities to reduce greenhouse gas emissions. A range of different scenarios was also developed to gain insights into how China's building sector might evolve and what the implications might be for improved building energy technology and carbon policies. The analysis suggests that China's building energy growth will not wane anytime soon, although technology improvement will put downward pressure on this growth: In the reference scenarios, the sector's final energy demand will increase by 110–150% by 2050 and 160–220% by 2095 from its 2005 level. Also, regardless of the scenarios represented, the growth will involve the continued, rapid electrification of the buildings sector throughout the century, and this transition will be accelerated by the implementation of carbon policy. -- Highlights: ► We developed a building energy model for China, nested in an integrated-assessment framework. ► We explore long-term pathways of China's building energy use by implementing a range of scenarios. ► China's building energy consumption will continue to grow and be electrified over the century. ► Improved building energy technology will slow down the growth in building energy consumption. ► Electrification will be accelerated by the implementation of carbon policy.

Adipose tissue remodeling in late-lactation dairy cows during feed-restriction-induced negative energy balance.

Science.gov (United States)

Contreras, G Andres; Thelen, Kyan; Schmidt, Sarah E; Strieder-Barboza, Clarissa; Preseault, Courtney L; Raphael, William; Kiupel, Matti; Caron, John; Lock, Adam L

2016-12-01

Excessive rates of demand lipolysis in the adipose tissue (AT) during periods of negative energy balance (NEB) are associated with increased susceptibility to disease and limited lactation performance. Lipolysis induces a remodeling process within AT that is characterized by an inflammatory response, cellular proliferation, and changes in the extracellular matrix (ECMT). The adipose tissue macrophage (ATM) is a key component of the inflammatory response. Infiltration of ATM-forming cellular aggregates was demonstrated in transition cows, suggesting that ATM trafficking and phenotype changes may be associated with disease. However, it is currently unknown if ATM infiltration occurs in dairy cows only during NEB states related to the transition period or also during NEB-induced lipolysis at other stages of lactation. The objective of this study was to evaluate changes in ATM trafficking and inflammatory phenotypes, and the expression of genetic markers of AT remodeling in healthy late-lactation cows during feed restriction-induced NEB. After a 14-d (d -14 to d -1) preliminary period, Holstein cows were randomly assigned to 1 of 2 feeding protocols, ad libitum (AL) or feed restriction (FR), for 4 d (d 1-4). Caloric intake was reduced in FR to achieve a targeted energy balance of -15 Mcal/d of net energy for lactation. Omental and subcutaneous AT samples were collected laparoscopically to harvest stromal vascular fraction (SVF) cells on d -3 and 4. The FR induced a NEB of -14.1±0.62 Mcal/d of net energy for lactation, whereas AL cows remained in positive energy balance (3.2±0.66 Mcal/d of NE L ). The FR triggered a lipolytic response reflected in increased plasma nonesterified fatty acids (0.65±0.05 mEq/L on d 4), enhanced phosphorylation of hormone sensitive lipase, and reduced adipocyte diameter. Flow cytometry and immunohistochemistry analysis revealed that on d 4, FR cows had increased numbers of CD172a + , an ATM (M1 and M2) surface marker, cells in SVF that

Diagnosis of district potential in terms of renewable energies. Report 1 - Present situation: Assessment of renewable energy production, Identification and quantification of territory's potentialities in terms of renewable energies

International Nuclear Information System (INIS)

2010-10-01

After a presentation of the Gers district context (geography, administrative organisation, demography, housing, economy, expertise), the report presents the energy situation, an overview of the solar thermal sector (installations and installers), of the solar photovoltaic sector (existing and projected installations, installers), of hydroelectricity, of wood-energy (individual heating, industrial heating plants, planned installations), of wind energy, of biogas, and of geothermal energy (existing and planned installations). It proposes an assessment of these energies as a whole. Then, after an overview of the district situation with respect to national objectives and to other districts of the region, the study reports an identification and quantification of potentialities in terms of theoretical resources for different energy sources (solar, wind, hydraulic, wood, methanization, valorizable biomass, geothermal, and agri-fuels). Avoided CO 2 emissions are assessed

Short-term energy outlook, April 1999

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-04-01

The forecast period for this issue of the Outlook extends from April 1999 through December 2000. Data values for the first quarter 1999, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in EIA`s Weekly Petroleum Status Report) or are calculated from model simulations that use the latest exogenous information available (for example, electricity sales and generation are simulated by using actual weather data). The historical energy data, compiled in the April 1999 version of the Short-Term Integrated forecasting system (STIFS) database, are mostly EIA data regularly published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding. The STIFS model is driven principally by three sets of assumptions or inputs: estimates of key macroeconomic variables, world oil price assumptions, and assumptions about the severity of weather. Macroeconomic estimates are produced by DRI/McGraw-Hill but are adjusted by EIA to reflect EIA assumptions about the world price of crude oil, energy product prices, and other assumptions which may affect the macroeconomic outlook. By varying the assumptions, alternative cases are produced by using the STIFS model. 25 figs., 19 tabs.

Prediction of mass excess, β-decay energy and neutron separation energy from the atomic mass formula with empirical shell terms

International Nuclear Information System (INIS)

Ando, Yoshihira; Uno, Masahiro; Yamada, Masami

1983-02-01

Recently we proposed two types of atomic mass formula (constant-shell-term formula, linear-shell-term formula). With use of these formulas, we calculate and tabulate mass excesses, neutron separation energies, and β-decay energies (β-decay and/or electron capture) for about 5000 nuclides. The mass excess values and their errors in the 1977 atomic mass evaluation by A.H. Wapstra and K. Bos which we used in constructing our formulas, are also tabulated for reference. The constant-shell-term formula is fitted to 1468 input mass data with the standard deviation of 626 keV and the linear-shell-term formula with 394 keV

Prediction of mass excess, #betta#-decay energy and neutron separation energy from the atomic mass formula with empirical shell terms

International Nuclear Information System (INIS)

Ando, Yoshihira; Uno, Masahiro; Yamada, Masami.

1983-02-01

Recently we proposed two types of atomic mass formula (constant-shell-term formula, linear-shell-term formula). With use of these formulas, we calculate and tabulate mass excesses, neutron separation energies, and #betta#-decay energies (#betta# - -decay and/or electron capture) for about 5000 nuclides. The mass excess values and their errors in the 1977 atomic mass evaluation by A.H. Wapstra and K. Bos which we used in constructing our formulas, are also tabulated for reference. The constant-shell-term formula is fitted to 1468 input mass data with the standard deviation of 626 keV and the linear-shell-term formula with 394 keV. (author)

48 CFR 252.227-7037 - Validation of restrictive markings on technical data.

Science.gov (United States)

2010-10-01

.... However, this clause neither creates nor implies privity of contract between the Government and... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.227-7037 Validation of restrictive markings on... following clause: Validation of Restrictive Markings on Technical Data (SEP 1999) (a) Definitions. The terms...

Evaluation of selected near-term energy-conservation options for the Midwest

Energy Technology Data Exchange (ETDEWEB)

Evans, A.R.; Colsher, C.S.; Hamilton, R.W.; Buehring, W.A.

1978-11-01

This report evaluates the potential for implementation of near-term energy-conservation practices for the residential, commercial, agricultural, industrial, transportation, and utility sectors of the economy in twelve states: Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin. The information used to evaluate the magnitude of achievable energy savings includes regional energy use, the regulatory/legislative climate relating to energy conservation, technical characteristics of the measures, and their feasibility of implementation. This work is intended to provide baseline information for an ongoing regional assessment of energy and environmental impacts in the Midwest. 80 references.

Short-term energy outlook, October 1998. Quarterly projections, 1998 4. quarter

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-10-01

The Energy Information Administration (EIA) prepares The Short-Term Energy Outlook (energy supply, demand, and price projections) monthly for distribution on the Internet at: www.eia.doe.gov/emeu/steo/pub/contents.html. In addition, printed versions of the report are available to subscribers in January, April, July and October. The forecast period for this issue of the Outlook extends from October 1998 through December 1999. Values for third quarter of 1998 data, however, are preliminary EIA estimates (for example, some monthly values for petroleum supply and disposition are derived in part from weekly data reported in EIA`s Weekly Petroleum Status Report) or are calculated from model simulations that use the latest exogenous information available (for example, electricity sales and generation are simulated by using actual weather data). The historical energy data, compiled in the October 1998 version of the Short-term Integrated Forecasting System (STIFS) database, are mostly EIA data regularly published in the Monthly Energy Review, Petroleum Supply Monthly, and other EIA publications. Minor discrepancies between the data in these publications and the historical data in this Outlook are due to independent rounding.

Focusing and restricting: two aspects of motivational selectivity in adulthood.

Science.gov (United States)

Riediger, Michaela; Freund, Alexandra M

2006-03-01

Using a short-term longitudinal design, the authors investigated implications of 2 facets of motivational selectivity--restricting (to few goals) and focusing (on central and similar goals)--for goal-pursuit investment. Participants were 20-69 years old (Time 1, N = 177; Time 2, N = 160). Results show that motivational selectivity in terms of focusing (but not in terms of restricting) is associated with an enhanced involvement in goal pursuit (assessed 3 months later), irrespective of age. Structural equation models demonstrated that this association is completely mediated by the degree of mutual facilitation among goals. Furthermore, motivational selectivity increases from middle to older adulthood. This contributes to the maintenance of high goal involvement into later adulthood, despite aging-related increases in resource limitations. ((c) 2006 APA, all rights reserved).

Biomass for biogas plants in Denmark - in the short and long term; Biomasse til biogasanlaeg i Danmark - pae kort og langt sigt

Energy Technology Data Exchange (ETDEWEB)

Birkmose, T.; Hjort-Gregersen, K.; Stefanek, K.

2013-04-15

In the short term, it is one of the major challenges for the developments of the biogas sector that resources of organic waste of the type (organic industrial wastes) that have heretofore been used, generally are estimated to be nearly exhausted. This has led to a number of new biogas projects based on the use of corn (energy crops) as additional biomass to livestock manure. However, Danish policy now has implemented a restriction on the use of corn and other energy crops for biogas production. It is with the restriction clarified that there is a need to use other additional biomass for biogas production. There is a need in the short term to clarify how alternative biomasses such as straw, nature preservation biomass, household waste, etc. in a technically and economically reliable and satisfactory way can be used for biogas production, so that the dependence of energy crops can be reduced. Additionally, it will be essential if the yield of using manure can be increased to reduce economic dependence on energy crops. In the longer term it is essential to strengthen the assessment of the resource potential of biomass available for the production of biogas, and thus what the contribution of biogas in the long term is estimated to be in the future energy supply based on renewable energy. The present report presents the current and future biomass resources potential and biogas production potential. The biomass resources are primarily agricultural and municipal wastes. (LN)

10 CFR 76.119 - Security facility approval and safeguarding of National Security Information and Restricted Data.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Security facility approval and safeguarding of National Security Information and Restricted Data. 76.119 Section 76.119 Energy NUCLEAR REGULATORY COMMISSION... approval and safeguarding of National Security Information and Restricted Data. The requirements for...

Examination of Cognitive Function During Six Months of Calorie Restriction: Results of a Randomized Controlled Trial

Science.gov (United States)

Martin, Corby K.; Anton, Stephen D.; Han, Hongmei; York-Crowe, Emily; Redman, Leanne M.; Ravussin, Eric; Williamson, Donald A.

2009-01-01

Background Calorie restriction increases longevity in many organisms, and calorie restriction or its mimetic might increase longevity in humans. It is unclear if calorie restriction/dieting contributes to cognitive impairment. During this randomized controlled trial, the effect of 6 months of calorie restriction on cognitive functioning was tested. Methods Participants (n = 48) were randomized to one of four groups: (1) control (weight maintenance), (2) calorie restriction (CR; 25% restriction), (3) CR plus structured exercise (CR + EX, 12.5% restriction plus 12.5% increased energy expenditure via exercise), or (4) low-calorie diet (LCD; 890 kcal/d diet until 15% weight loss, followed by weight maintenance). Cognitive tests (verbal memory, visual memory, attention/concentration) were conducted at baseline and months 3 and 6. Mixed linear models tested if cognitive function changed significantly from baseline to months 3 and 6, and if this change differed by group. Correlation analysis was used to determine if average daily energy deficit (quantified from change in body energy stores) was associated with change in cognitive test performance for the three dieting groups combined. Results No consistent pattern of verbal memory, visual retention/memory, or attention/concentration deficits emerged during the trial. Daily energy deficit was not significantly associated with change in cognitive test performance. Conclusions This randomized controlled trial suggests that calorie restriction/dieting was not associated with a consistent pattern of cognitive impairment. These conclusions must be interpreted in the context of study limitations, namely small sample size and limited statistical power. Previous reports of cognitive impairment might reflect sampling biases or information processing biases. PMID:17518698

Long-term functional outcomes and correlation with regional brain connectivity by MRI diffusion tractography metrics in a near-term rabbit model of intrauterine growth restriction.

Directory of Open Access Journals (Sweden)

Miriam Illa

Full Text Available BACKGROUND: Intrauterine growth restriction (IUGR affects 5-10% of all newborns and is associated with increased risk of memory, attention and anxiety problems in late childhood and adolescence. The neurostructural correlates of long-term abnormal neurodevelopment associated with IUGR are unknown. Thus, the aim of this study was to provide a comprehensive description of the long-term functional and neurostructural correlates of abnormal neurodevelopment associated with IUGR in a near-term rabbit model (delivered at 30 days of gestation and evaluate the development of quantitative imaging biomarkers of abnormal neurodevelopment based on diffusion magnetic resonance imaging (MRI parameters and connectivity. METHODOLOGY: At +70 postnatal days, 10 cases and 11 controls were functionally evaluated with the Open Field Behavioral Test which evaluates anxiety and attention and the Object Recognition Task that evaluates short-term memory and attention. Subsequently, brains were collected, fixed and a high resolution MRI was performed. Differences in diffusion parameters were analyzed by means of voxel-based and connectivity analysis measuring the number of fibers reconstructed within anxiety, attention and short-term memory networks over the total fibers. PRINCIPAL FINDINGS: The results of the neurobehavioral and cognitive assessment showed a significant higher degree of anxiety, attention and memory problems in cases compared to controls in most of the variables explored. Voxel-based analysis (VBA revealed significant differences between groups in multiple brain regions mainly in grey matter structures, whereas connectivity analysis demonstrated lower ratios of fibers within the networks in cases, reaching the statistical significance only in the left hemisphere for both networks. Finally, VBA and connectivity results were also correlated with functional outcome. CONCLUSIONS: The rabbit model used reproduced long-term functional impairments and their

Long-Term Functional Outcomes and Correlation with Regional Brain Connectivity by MRI Diffusion Tractography Metrics in a Near-Term Rabbit Model of Intrauterine Growth Restriction

Science.gov (United States)

Illa, Miriam; Eixarch, Elisenda; Batalle, Dafnis; Arbat-Plana, Ariadna; Muñoz-Moreno, Emma; Figueras, Francesc; Gratacos, Eduard

2013-01-01

Background Intrauterine growth restriction (IUGR) affects 5–10% of all newborns and is associated with increased risk of memory, attention and anxiety problems in late childhood and adolescence. The neurostructural correlates of long-term abnormal neurodevelopment associated with IUGR are unknown. Thus, the aim of this study was to provide a comprehensive description of the long-term functional and neurostructural correlates of abnormal neurodevelopment associated with IUGR in a near-term rabbit model (delivered at 30 days of gestation) and evaluate the development of quantitative imaging biomarkers of abnormal neurodevelopment based on diffusion magnetic resonance imaging (MRI) parameters and connectivity. Methodology At +70 postnatal days, 10 cases and 11 controls were functionally evaluated with the Open Field Behavioral Test which evaluates anxiety and attention and the Object Recognition Task that evaluates short-term memory and attention. Subsequently, brains were collected, fixed and a high resolution MRI was performed. Differences in diffusion parameters were analyzed by means of voxel-based and connectivity analysis measuring the number of fibers reconstructed within anxiety, attention and short-term memory networks over the total fibers. Principal Findings The results of the neurobehavioral and cognitive assessment showed a significant higher degree of anxiety, attention and memory problems in cases compared to controls in most of the variables explored. Voxel-based analysis (VBA) revealed significant differences between groups in multiple brain regions mainly in grey matter structures, whereas connectivity analysis demonstrated lower ratios of fibers within the networks in cases, reaching the statistical significance only in the left hemisphere for both networks. Finally, VBA and connectivity results were also correlated with functional outcome. Conclusions The rabbit model used reproduced long-term functional impairments and their neurostructural

Fasting or caloric restriction for healthy aging.

Science.gov (United States)

Anton, Stephen; Leeuwenburgh, Christiaan

2013-10-01

Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss of independence, and increased risk of mortality. To date, prolonged caloric restriction (i.e., a reduction in caloric intake without malnutrition) is the only non-genetic intervention that has consistently been found to extend both mean and maximal life span across a variety of species. Most individuals have difficulty sustaining prolonged caloric restriction, which has led to a search for alternative approaches that can produce similar to benefits as caloric restriction. A growing body of evidence indicates that fasting periods and intermittent fasting regimens in particular can trigger similar biological pathways as caloric restriction. For this reason, there is increasing scientific interest in further exploring the biological and metabolic effects of intermittent fasting periods, as well as whether long-term compliance may be improved by this type of dietary approach. This special will highlight the latest scientific findings related to the effects of both caloric restriction and intermittent fasting across various species including yeast, fruit flies, worms, rodents, primates, and humans. A specific emphasis is placed on translational research with findings from basic bench to bedside reviewed and practical clinical implications discussed. Copyright © 2013 Elsevier Inc. All rights reserved.

Modelling the long-term deployment of electricity storage in the global energy system

International Nuclear Information System (INIS)

Despres, Jacques

2015-01-01

The current development of wind and solar power sources calls for an improvement of long-term energy models. Indeed, high shares of variable wind and solar productions have short- and long-term impacts on the power system, requiring the development of flexibility options: fast-reacting power plants, demand response, grid enhancement or electricity storage. Our first main contribution is the modelling of electricity storage and grid expansion in the POLES model (Prospective Outlook on Long-term Energy Systems). We set up new investment mechanisms, where storage development is based on several combined economic values. After categorising the long-term energy models and the power sector modelling tools in a common typology, we showed the need for a better integration of both approaches. Therefore, the second major contribution of our work is the yearly coupling of POLES to a short-term optimisation of the power sector operation, with the European Unit Commitment and Dispatch model (EUCAD). The two-way data exchange allows the long-term coherent scenarios of POLES to be directly backed by the short-term technical detail of EUCAD. Our results forecast a strong and rather quick development of the cheapest flexibility options: grid interconnections, pumped hydro storage and demand response programs, including electric vehicle charging optimisation and vehicle-to-grid storage. The more expensive battery storage presumably finds enough system value in the second half of the century. A sensitivity analysis shows that improving the fixed costs of batteries impacts more the investments than improving their efficiency. We also show the explicit dependency between storage and variable renewable energy sources. (author) [fr

Dietary sodium restriction in the prophylaxis of hypertensive disorders of pregnancy: effects on the intake of other nutrients.

Science.gov (United States)

van Buul, B J; Steegers, E A; Jongsma, H W; Rijpkema, A L; Eskes, T K; Thomas, C M; Baadenhuysen, H; Hein, P R

1995-07-01

Dietary sodium restriction is used in the Netherlands in the prophylaxis of preeclampsia. To study the effects of long-term sodium restriction on the intake of other nutrients and the outcome of pregnancy, 68 healthy nulliparous pregnant women were randomly assigned to either a low-sodium diet (20 mmol/24 h) or an unrestricted diet. The diet was consumed between week 14 of gestation and delivery. The dietary intakes of energy, fat, protein, carbohydrate, sodium, potassium, and calcium were estimated with the dietary-history technique. A low-sodium diet reduced the intake of protein (by approximately 15 g/24 h), fat (by 20 g/24 h), and calcium (by 350 mg/24 h) and tended to decrease the energy intake (by approximately 0.7 MJ/24 h). The intakes of carbohydrate and potassium did not differ between the groups. The maternal weight gain was less in the low-sodium group (6.0 +/- 3.7 compared with 11.7 +/- 4.7 kg). Mean birth weight was not significantly different (3.2 +/- 0.5 compared with 3.4 +/- 0.5 kg).

Hanford land disposal restrictions plan for mixed wastes

International Nuclear Information System (INIS)

1990-10-01

Since the early 1940s, the Hanford Site has been involved in the production and purification of nuclear defense materials. These production activities have resulted in the generation of large quantities of liquid and solid radioactive mixed waste. This waste is subject to regulation under authority of both the Resource Conservation and Recovery Act of 1976 (RCRA) and the Atomic Energy Act. The State of Washington Department of Ecology (Ecology), the US Environmental Protection Agency (EPA), and the US Department of Energy (DOE) have entered into an agreement, the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) to bring Hanford Site Operations into compliance with dangerous waste regulations. The Tri-Party Agreement was amended to require development of the Hanford Land Disposal Restrictions Plan for Mixed Wastes (this plan) to comply with land disposal restrictions requirements for radioactive mixed waste. The Tri-Party Agreement requires, and the this plan provides, the following sections: Waste Characterization Plan, Storage Report, Treatment Report, Treatment Plan, Waste Minimization Plan, a schedule, depicting the events necessary to achieve full compliance with land disposal restriction requirements, and a process for establishing interim milestones. 34 refs., 28 figs., 35 tabs

Hanford land disposal restrictions plan for mixed wastes

Energy Technology Data Exchange (ETDEWEB)

1990-10-01

Since the early 1940s, the Hanford Site has been involved in the production and purification of nuclear defense materials. These production activities have resulted in the generation of large quantities of liquid and solid radioactive mixed waste. This waste is subject to regulation under authority of both the Resource Conservation and Recovery Act of 1976 (RCRA) and the Atomic Energy Act. The State of Washington Department of Ecology (Ecology), the US Environmental Protection Agency (EPA), and the US Department of Energy (DOE) have entered into an agreement, the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) to bring Hanford Site Operations into compliance with dangerous waste regulations. The Tri-Party Agreement was amended to require development of the Hanford Land Disposal Restrictions Plan for Mixed Wastes (this plan) to comply with land disposal restrictions requirements for radioactive mixed waste. The Tri-Party Agreement requires, and the this plan provides, the following sections: Waste Characterization Plan, Storage Report, Treatment Report, Treatment Plan, Waste Minimization Plan, a schedule, depicting the events necessary to achieve full compliance with land disposal restriction requirements, and a process for establishing interim milestones. 34 refs., 28 figs., 35 tabs.

Skyrmion vibrational energies together with a generalized mass term

International Nuclear Information System (INIS)

Davies, Merlin C.; Marleau, Luc

2009-01-01

We study various properties of a one-parameter mass term for the Skyrme model, originating from the works of Kopeliovich, Piette and Zakrzewski [V. B. Kopeliovich, B. Piette, and W. J. Zakrzewski, Phys. Rev. D 73, 014006 (2006).], through the use of axially symmetric solutions obtained numerically by simulated-annealing. These solutions allow us to observe asymptotic behaviors of the B=2 binding energies that differ to those previously obtained [B. Piette and W. J. Zakrzewski, Phys. Rev. D 77, 074009 (2008).]. We also decipher the characteristics of three distinct vibrational modes that appear as eigenstates of the vibrational Hamiltonian. This analysis further examine the assertion that the one-parameter mass term offers a better account of baryonic matter than the traditional mass term.

Long term agreements energy efficiency. Progress 1999

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-11-01

Long Term Agreements (LTAs) on energy efficiency have been contracted with various business sectors since 1992, as part of energy conservation policy: industrial sectors, commercial services, agrarian sectors and non-profit services. LTAs are voluntary agreements between a specific sector and the Minister of Economic Affairs. In some cases, the Minister of Agriculture, Nature Management and Fisheries is also involved. The sector commits to an effort to improve energy efficiency by a particular percentage within an agreed period. As at 31 December 1999, a total of 29 LTAs had been contracted with industrial sectors and 14 with non-industrial ones. This report describes the progress of the LTAs in 1999. It reviews the energy efficiency improvements realised through the LTAs, both overall and in each individual sector. The aim is to make the efforts and results in the various sectors accessible to the general public. Appendix 1 describes the positioning of the LTA instrument. This Appendix provides and insight into the position of the LTAs within the overall set of policy instruments. It also covers the subsidy schemes and fiscal instruments that support the LTAs, the relationships between LTAs and environmental policy and new developments relating to the LTAs in the years ahead. Appendices 2 to 6 contain the reports on the LTAs and a list of abbreviations (Appendix 7)

Long-term optimal energy mix planning towards high energy security and low GHG emission

International Nuclear Information System (INIS)

Thangavelu, Sundar Raj; Khambadkone, Ashwin M.; Karimi, Iftekhar A.

2015-01-01

Highlights: • We develop long-term energy planning considering the future uncertain inputs. • We analyze the effect of uncertain inputs on the energy cost and energy security. • Conventional energy mix prone to cause high energy cost and energy security issues. • Stochastic and optimal energy mix show benefits over conventional energy planning. • Nuclear option consideration reduces the energy cost and carbon emissions. - Abstract: Conventional energy planning focused on energy cost, GHG emission and renewable contribution based on future energy demand, fuel price, etc. Uncertainty in the projected variables such as energy demand, volatile fuel price and evolution of renewable technologies will influence the cost of energy when projected over a period of 15–30 years. Inaccurate projected variables could affect energy security and lead to the risk of high energy cost, high emission and low energy security. The energy security is an ability of generation capacity to meet the future energy demand. In order to minimize the risks, a generic methodology is presented to determine an optimal energy mix for a period of around 15 years. The proposed optimal energy mix is a right combination of energy sources that minimize the risk caused due to future uncertainties related to the energy sources. The proposed methodology uses stochastic optimization to address future uncertainties over a planning horizon and minimize the variations in the desired performance criteria such as energy security and costs. The developed methodology is validated using a case study for a South East Asian region with diverse fuel sources consists of wind, solar, geothermal, coal, biomass and natural gas, etc. The derived optimal energy mix decision outperformed the conventional energy planning by remaining stable and feasible against 79% of future energy demand scenarios at the expense of 0–10% increase in the energy cost. Including the nuclear option in the energy mix resulted 26

Transcriptome Analysis of the Thymus in Short-Term Calorie-Restricted Mice Using RNA-seq

Directory of Open Access Journals (Sweden)

Zehra Omeroğlu Ulu

2018-01-01

Full Text Available Calorie restriction (CR, which is a factor that expands lifespan and an important player in immune response, is an effective protective method against cancer development. Thymus, which plays a critical role in the development of the immune system, reacts to nutrition deficiency quickly. RNA-seq-based transcriptome sequencing was performed to thymus tissues of MMTV-TGF-α mice subjected to ad libitum (AL, chronic calorie restriction (CCR, and intermittent calorie restriction (ICR diets in this study. Three cDNA libraries were sequenced using Illumina HiSeq™ 4000 to produce 100 base pair-end reads. On average, 105 million clean reads were mapped and in total 6091 significantly differentially expressed genes (DEGs were identified (p<0.05. These DEGs were clustered into Gene Ontology (GO categories. The expression pattern revealed by RNA-seq was validated by quantitative real-time PCR (qPCR analysis of four important genes, which are leptin, ghrelin, Igf1, and adinopectin. RNA-seq data has been deposited in NCBI Gene Expression Omnibus (GEO database (GSE95371. We report the use of RNA sequencing to find DEGs that are affected by different feeding regimes in the thymus.

Transcriptome Analysis of the Thymus in Short-Term Calorie-Restricted Mice Using RNA-seq

Science.gov (United States)

Omeroğlu Ulu, Zehra; Ulu, Salih; Dogan, Soner; Guvenc Tuna, Bilge

2018-01-01

Calorie restriction (CR), which is a factor that expands lifespan and an important player in immune response, is an effective protective method against cancer development. Thymus, which plays a critical role in the development of the immune system, reacts to nutrition deficiency quickly. RNA-seq-based transcriptome sequencing was performed to thymus tissues of MMTV-TGF-α mice subjected to ad libitum (AL), chronic calorie restriction (CCR), and intermittent calorie restriction (ICR) diets in this study. Three cDNA libraries were sequenced using Illumina HiSeq™ 4000 to produce 100 base pair-end reads. On average, 105 million clean reads were mapped and in total 6091 significantly differentially expressed genes (DEGs) were identified (p < 0.05). These DEGs were clustered into Gene Ontology (GO) categories. The expression pattern revealed by RNA-seq was validated by quantitative real-time PCR (qPCR) analysis of four important genes, which are leptin, ghrelin, Igf1, and adinopectin. RNA-seq data has been deposited in NCBI Gene Expression Omnibus (GEO) database (GSE95371). We report the use of RNA sequencing to find DEGs that are affected by different feeding regimes in the thymus. PMID:29511668

[Long-term outcome in context of intra uterine growth restriction and/or small for gestational age newborns].

Science.gov (United States)

Gascoin, G; Flamant, C

2013-12-01

To evaluate long-term outcome after history of intra-uterine growth restriction (IUGR) and/or birth small for gestational age (SGA). This systematic evidence review is based on Pubmed search, Cochrane library and experts recommendations. Neurodevelopmental evaluation at 2 years is lower in those infants, born premature or not. SGA is associated with a high risk of minor cognitive deficiencies, hyperactivity or attention deficit disorders at 5 years or scholar difficulties at 8 years. Those infants are at high risk of metabolic syndrome in adulthood. Most of them will catch up at 6 months for weight and 12 months for height. Even if IUGR is associated with high risk of bronchodysplasia, up to this day, the review of literature did not permit to evaluate respiratory outcome. Adults born SGA have good quality of live and normal professional insertion. One cohort study and more and more animal studies suggest potential trans generational effects. Infants born SGA and/or with history of IUGR are at high risk of minor cognitive deficiencies and scholar difficulties. They are also at high risk of metabolic syndrome in adulthood. However, prematurity seems to have a higher effect than IUGR and/or SGA on long-term outcomes. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Climate Policy in Terms of Open Energy Market

International Nuclear Information System (INIS)

Granic, G.

2015-01-01

This paper describes the objectives and approach to the climate policy impact analysis on the development of energy sector. The analysis included the goals for CO2 emission reduction until 2050, by sectors and in total, with reference to last 5-10 years. The analysis of energy market development in terms of CO2 emission reduction is given, and also the analysis of the final consumption for Croatia in period until 2050. The analysis of measures, of the manner in which the measures are carried out and of the potential of measures for CO2 emission reduction is presented. Estimations of economic and financial indicators for measurement implementation are given. Technological, energy, economic, organizational and institutional limitations are specifically analysed as part of objectives realisation of CO2 emission reduction, as is the risk of measurement implementation. The important parts of CO2 emission reduction policy are: technological development, expectations and possible risks of not achieving the set objectives. The important assumption of CO2 emission reduction objective realisation is institutional organisation of creation of energy policy and measurement implementation, in which the important measure is the forming of Ministry of energy, environment protection and climate change. At the end, recommendations are given, based on the performed analysis. (author).

Incremental Effect of the Addition of Prescriber Restrictions on a State Medicaid's Pharmacy-Only Patient Review and Restriction Program.

Science.gov (United States)

Keast, Shellie L; Pham, Timothy; Teel, Ashley; Nesser, Nancy J

2017-08-01

Patient review and restriction programs (PRRPs), used by state Medicaid programs to limit potential abuse and misuse of opioids and related controlled medications, often restrict members to a single pharmacy for controlled medications. While most states use a restricted pharmacy access model, not all states include restricted prescriber access. Oklahoma Medicaid (MOK) added a restricted prescriber access feature to its PRRP in July 2014. To evaluate the incremental effect that the addition of a prescriber restriction to MOK's pharmacy-only PRRP had on the pharmacy and resource utilization of the enrolled members. MOK members with at least 6 months of enrollment in the pharmacy-only PRRP were restricted to a maximum of 3 prescribers for controlled substances in July 2014 and were identified as "cases." Using a propensity score method, cases were matched to controls from the MOK non-PRRP enrolled population based on demographics and baseline health care utilization. Data from January 1, 2014, through December 31, 2014, were evaluated. Each member's monthly health care resource utilization, defined in terms of medical and pharmacy costs, prescription counts, and opioid use per member per month (PMPM), was analyzed. A difference-indifferences (DID) regression estimated the change in resource utilization following the July 2014 policy change. This study included 378 controls and 126 cases after propensity matching. No differences were noted for daily morphine equivalents, benzodiazepine prescriptions, or maintenance prescriptions. There were decreases in mean PMPM use for both groups for short-acting opioid (SAO) claims (P evidence that overall opioid claims were affected, the addition of prescriber restrictions may have resulted in an incremental change to SAO, prescriber, and pharmacy use in the PRPP population. Use of PRRPs may be an effective tool in reducing inappropriate use of prescription opioids within payer systems. The question remains whether these changes

Low Birth Weight due to Intrauterine Growth Restriction and/or Preterm Birth: Effects on Nephron Number and Long-Term Renal Health

Science.gov (United States)

Zohdi, Vladislava; Sutherland, Megan R.; Lim, Kyungjoon; Gubhaju, Lina; Zimanyi, Monika A.; Black, M. Jane

2012-01-01

Epidemiological studies have clearly demonstrated a strong association between low birth weight and long-term renal disease. A potential mediator of this long-term risk is a reduction in nephron endowment in the low birth weight infant at the beginning of life. Importantly, nephrons are only formed early in life; during normal gestation, nephrogenesis is complete by about 32–36 weeks, with no new nephrons formed after this time during the lifetime of the individual. Hence, given that a loss of a critical number of nephrons is the hallmark of renal disease, an increased severity and acceleration of renal disease is likely when the number of nephrons is already reduced prior to disease onset. Low birth weight can result from intrauterine growth restriction (IUGR) or preterm birth; a high proportion of babies born prematurely also exhibit IUGR. In this paper, we describe how IUGR and preterm birth adversely impact on nephrogenesis and how a subsequent reduced nephron endowment at the beginning of life may lead to long-term risk of renal disease, but not necessarily hypertension. PMID:22970368

Low Birth Weight due to Intrauterine Growth Restriction and/or Preterm Birth: Effects on Nephron Number and Long-Term Renal Health

Directory of Open Access Journals (Sweden)

Vladislava Zohdi

2012-01-01

Full Text Available Epidemiological studies have clearly demonstrated a strong association between low birth weight and long-term renal disease. A potential mediator of this long-term risk is a reduction in nephron endowment in the low birth weight infant at the beginning of life. Importantly, nephrons are only formed early in life; during normal gestation, nephrogenesis is complete by about 32–36 weeks, with no new nephrons formed after this time during the lifetime of the individual. Hence, given that a loss of a critical number of nephrons is the hallmark of renal disease, an increased severity and acceleration of renal disease is likely when the number of nephrons is already reduced prior to disease onset. Low birth weight can result from intrauterine growth restriction (IUGR or preterm birth; a high proportion of babies born prematurely also exhibit IUGR. In this paper, we describe how IUGR and preterm birth adversely impact on nephrogenesis and how a subsequent reduced nephron endowment at the beginning of life may lead to long-term risk of renal disease, but not necessarily hypertension.

Assessment of nuclear energy cost competitiveness against alternative energy sources in Romania envisaging the long-term national energy sustainability

International Nuclear Information System (INIS)

Margeanu, C. A.

2016-01-01

The paper includes some of the results obtained by RATEN ICN Pitesti experts in the IAEA.s Collaborative Project INPRO-SYNERGIES. The case study proposed to evaluate and analyze the nuclear capacity development and increasing of its share in the national energy sector, envisaging the long term national and regional energy sustainability by keeping collaboration options open for the future while bringing solutions to short/medium-term challenges. The following technologies, considered as future competing technologies for electric energy generation in Romania, were selected: nuclear technology (represented by PHWR CANDU Units 3 and 4 - CANDU new, advanced HWR - Adv. HWR, and advanced PWR - Adv. PWR) and, as alternative energy sources, classical technology (represented by Coal-fired power plant using lignite fossil fuel, with carbon capture - Coal_new, and Gas-fired power plant operating on combined cycle, with carbon capture - Gas_new). The study included assessment of specific economic indicators, sensitivity analyses being performed on Levelised Unit Energy Cost (LUEC) variation due to different perturbations (e.g. discount rate, overnight costs, etc). Robustness indices (RI) of LUEC were also calculated by considering simultaneous variation of input parameters for the considered power plants. The economic analyses have been performed by using the IAEA.s NEST program. The study results confirmed that in Romania, under the national specific conditions defined, electricity produced by nuclear power plants is cost competitive against coal and gas fired power plants electricity. The highest impact of considered perturbations on LUEC has been observed for capital intensive technologies (nuclear technologies) comparatively with the classic power plants, especially for discount rate changes. (authors)

Grout Treatment Facility Land Disposal Restriction Management Plan

International Nuclear Information System (INIS)

Hendrickson, D.W.

1991-01-01

This document establishes management plans directed to result in the land disposal of grouted wastes at the Hanford Grout Facilities in compliance with Federal, State of Washington, and Department of Energy land disposal restrictions. 9 refs., 1 fig

Sleep restriction progress to cardiac autonomic imbalance

African Journals Online (AJOL)

Arbind Kumar Choudhary

2017-05-31

May 31, 2017 ... and inadequate sleep is a common feature of night shift work. ... night watchmen during their working schedule, hence the purpose of our ... whether mental stress or fatigue over restricted sleep period in night ... 10 Hence, the variability in heart rate, (with reduced ..... Long-term cardiovascular outcomes.

Perspective of long term demand and supply of energy and general inspection of energy policy

International Nuclear Information System (INIS)

1983-01-01

Since the oil crisis, Japanese energy policy was promoted to get rid of the excess dependence on petroleum and to attain energy security, but energy situation largely changed during the past ten years, and it has become necessary to make general inspection on the long term demand and supply of energy and the energy policy. After the second oil crisis, the worldwide demand of petroleum decreased drastically due to the rapid price rise, and the base price of crude oil was lowered for the first time. It is necessary to positively endeavor to reduce energy cost with new idea. The points of the general inspection are the correspondence of the energy policy to the large structural change of energy, the most desirable system for attaining the optimum structure of energy demand and supply and the utilization of market mechanism as far as possible. This report is the results of discussion held eight times since April, 1983. The change of energy situation in Japan and abroad and the perspective, the new problems in energy countermeasures and the trend of response, the preferential and effective promotion of general energy countermeasures and so on are reported. This report shows the fundamental direction of energy countermeasures hereafter, and the concrete and special examination must be made on many remaining problems. (Kako, I.)

Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet

Science.gov (United States)

Ibero-Baraibar, Idoia; Suárez, Manuel; Arola-Arnal, Anna; Zulet, M. Angeles; Martinez, J. Alfredo

2016-01-01

Background Cardiometabolic profile is usually altered in obesity. Interestingly, the consumption of flavanol-rich foods might be protective against those metabolic alterations. Objective To evaluate the postprandial cardiometabolic effects after the acute consumption of cocoa extract before and after 4 weeks of its daily intake. Furthermore, the bioavailability of cocoa extract was investigated. Design Twenty-four overweight/obese middle-aged subjects participated in a 4-week intervention study. Half of the volunteers consumed a test meal enriched with 1.4 g of cocoa extract (415 mg flavanols), while the rest of the volunteers consumed the same meal without the cocoa extract (control group). Glucose and lipid profile, as well as blood pressure and cocoa metabolites in plasma, were assessed before and at 60, 120, and 180 min post-consumption, at the beginning of the study (Postprandial 1) and after following a 4-week 15% energy-restricted diet including meals containing or not containing the cocoa extract (Postprandial 2). Results In the Postprandial 1 test, the area under the curve (AUC) of systolic blood pressure (SBP) was significantly higher in the cocoa group compared with the control group (p=0.007), showing significant differences after 120 min of intake. However, no differences between groups were observed at Postprandial 2. Interestingly, the reduction of postprandial AUC of SBP (AUC_Postprandial 2-AUC_Postprandial 1) was higher in the cocoa group (p=0.016). Furthermore, cocoa-derived metabolites were detected in plasma of the cocoa group, while the absence or significantly lower amounts of metabolites were found in the control group. Conclusions The daily consumption of cocoa extract within an energy-restricted diet for 4 weeks resulted in a greater reduction of postprandial AUC of SBP compared with the effect of energy-restricted diet alone and independently of body weight loss. These results suggest the role of cocoa flavanols on postprandial blood

Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet

Directory of Open Access Journals (Sweden)

Idoia Ibero-Baraibar

2016-03-01

Full Text Available Background: Cardiometabolic profile is usually altered in obesity. Interestingly, the consumption of flavanol-rich foods might be protective against those metabolic alterations. Objective: To evaluate the postprandial cardiometabolic effects after the acute consumption of cocoa extract before and after 4 weeks of its daily intake. Furthermore, the bioavailability of cocoa extract was investigated. Design: Twenty-four overweight/obese middle-aged subjects participated in a 4-week intervention study. Half of the volunteers consumed a test meal enriched with 1.4 g of cocoa extract (415 mg flavanols, while the rest of the volunteers consumed the same meal without the cocoa extract (control group. Glucose and lipid profile, as well as blood pressure and cocoa metabolites in plasma, were assessed before and at 60, 120, and 180 min post-consumption, at the beginning of the study (Postprandial 1 and after following a 4-week 15% energy-restricted diet including meals containing or not containing the cocoa extract (Postprandial 2. Results: In the Postprandial 1 test, the area under the curve (AUC of systolic blood pressure (SBP was significantly higher in the cocoa group compared with the control group (p=0.007, showing significant differences after 120 min of intake. However, no differences between groups were observed at Postprandial 2. Interestingly, the reduction of postprandial AUC of SBP (AUC_Postprandial 2-AUC_Postprandial 1 was higher in the cocoa group (p=0.016. Furthermore, cocoa-derived metabolites were detected in plasma of the cocoa group, while the absence or significantly lower amounts of metabolites were found in the control group. Conclusions: The daily consumption of cocoa extract within an energy-restricted diet for 4 weeks resulted in a greater reduction of postprandial AUC of SBP compared with the effect of energy-restricted diet alone and independently of body weight loss. These results suggest the role of cocoa flavanols on

Short Term Energy Storage for Grid Support in Wind Power Applications

DEFF Research Database (Denmark)

Stroe, Daniel Ioan; Stan, Ana-Irina; Diosi, Robert

2012-01-01

The penetration of wind power into the power system has been increasing in the recent years. Therefore, a lot of concerns related to the reliable operation of the power system have been addressed. An attractive solution to minimize the limitations faced by the wind power grid integration, and thus...... to increase the power system stability and the energy quality, is to integrate energy storage devices into wind power plants. This paper gives an overview of the state-of-the-art short-term energy storage devices and presents several applications which can be provided by the energy storage device - wind power...

Energy policy and the market economy

International Nuclear Information System (INIS)

Ruehle, H.; Miegel, M.

1980-01-01

The consistent supply of the people with cheap energy is one of the biggest challenges of our time. There is hardly any other sphere where the opinions on the correct means and ways are as different as in energy policy. While some people see only the market as a suitable instrument to solve the energy problems, others are of the opinion that the problems can only be solved by planning by the government, quantitative restrictions, and other directive measures. The answer to this question involves long-term results, not only for our future energy policy. Planned economy in the energy section and marketing in all other sections cannot be continued for ever. The clarification of this question is the goal of these lectures and discussions held on the experts' meeting 'energy policy in marketing'. (orig.) [de

Long-term scenarios for sustainable energy use in Germany

International Nuclear Information System (INIS)

Fischedick, M.; Nitsch, J.; Lechtenboehmer, S.; Hanke, T.; Barthel, C.; Jungbluth, C.; Assmann, D.; Brueggen, T. vor der; Trieb, F.; Nast, M.; Langniss, O.; Brischke, L.A.

2002-01-01

The study was able to show, and explain vividly through scenarios describing change processes, that a sustainable use of energy (aimed, among other things, at reducing CO 2 emissions by 80% by 2050 compared with 1990 levels) is technically feasible, economically viable, compatible with farther-reaching objectives of energy policy (e.g. supply security), and does not, in spite of the substantial need for change, present the players involved with any insurmountable problems but, rather, constitutes both a challenge and an opportunity. Such a development is possible only if the efforts launched to give momentum to the increased use of renewable energy sources are continued consistently, the impending need for replacement and renewal within the generation system is consistently utilised for increasing efficiency and a reorientation mainly towards combined heat and power production, and energy saving is made a new focal point of energy policy. Furthermore, with regard to long-term infrastructure requirements (decentralisation, new fuels), the necessary decisions must be prepared at an early stage and sufficiently robust lines of development must be identified and followed. (orig.) [de

Long term electricity expansion analysis to define energy policies for Mexico

International Nuclear Information System (INIS)

Martin del Campo, C.; Guadarrama, R.; Sanchez, O.; Francois, J. L.; Estrada, G.; Izarra, J.; Perez, A.

2010-10-01

A new multi-criteria decision making process based on regret behavior is described. The name we gave it is position vector of minimum regret. A reference which combines the best values of all the criteria is created and positioned in the center of the coordinates of the n-dimensional space; n being the number of criteria. Every alternative is represented by a vector and the magnitude of the position vector is the minimum distance to the reference. The smaller the magnitude of the position vector, the better the corresponding alternative, given that we are looking for the minimum regret. Different weights can be assigned to the criteria. The position vector of minimum regret was applied to the long term electricity expansion planning for Mexico. The study evaluates four parameters: the total generating cost obtained from the objective function after the WASP-IV optimization, the economic risk associated with fuel prices increases, the diversity of fuels participating in the mix of electricity generation, and the external costs associated with health and environmental impacts. The WASP-IV code was used for finding the optimal expansion plan for the Mexican power generating system over the 2008 to 2030 period, under certain restrictions. We decided to study a base case and four additional expansion cases, which are similar to the base case, but each does not consider a certain candidate technology which uses a particular fuel. The reason of studying these five contrasting cases is to quantify the impact, on the evaluation parameters, when a particular fuel is omitted in the expansion plan, and this is very useful for the definition of energy polices concerning diversification by means of nuclear and other CO 2 free options in the mix. The base case is plan A which considers six candidates for expanding the generation system. Plan B does not consider coal, plan C does not consider oil, plan D excludes nuclear energy, and plan E natural gas. After the decision analysis

The term structure of oil futures prices

International Nuclear Information System (INIS)

Gabillon, J.

1991-01-01

In recent years, there has been a massive development of derivative financial products in oil markets. The main interest came from large energy end-users who found in them a welcome opportunity to lock in fixed or maximum prices for their supplies over a period of time. Oil companies and oil traders were able to provide tailor-made swaps or options for the specific needs of the end-users. In this paper, we present a two-variable model of the term structures of futures prices and volatilities assuming that the spot and long-term prices of oil are stochastic, and are the main determinants of the convenience yield function. Although the resulting convenience yield is stochastic, the model admits an analytic formulation under some restrictions. (author)

Higher-order terms in the nuclear-energy-density functional

International Nuclear Information System (INIS)

Carlsson, B. G.; Borucki, M.; Dobaczewski, J.

2009-01-01

One of the current projects at the Department of Physics in the University of Jyvaeskylae is to explore more general forms of the Skyrme energy-density functional (EDF). The aim is to find new phenomenological terms which are sensitive to experimental data. In this context we have extended the Skyrme functional by including terms which contain higher orders of derivatives allowing for a better description of finite range effects. This was done by employing an expansion in derivatives in a spherical-tensor formalism [1] motivated by ideas of the density-matrix expansion. The resulting functionals have different number of free parameters depending on the order in derivatives and assumed symmetries, see Fig. 1. The usual Skyrme EDF is obtained as a second order expansion while we keep terms up to sixth order.(author)

An adaptive short-term prediction scheme for wind energy storage management

International Nuclear Information System (INIS)

Blonbou, Ruddy; Monjoly, Stephanie; Dorville, Jean-Francois

2011-01-01

Research highlights: → We develop a real time algorithm for grid-connected wind energy storage management. → The method aims to guarantee, with ±5% error margin, the power sent to the grid. → Dynamic scheduling of energy storage is based on short-term energy prediction. → Accurate predictions reduce the need in storage capacity. -- Abstract: Efficient forecasting scheme that includes some information on the likelihood of the forecast and based on a better knowledge of the wind variations characteristics along with their influence on power output variation is of key importance for the optimal integration of wind energy in island's power system. In the Guadeloupean archipelago (French West-Indies), with a total wind power capacity of 25 MW; wind energy can represent up to 5% of the instantaneous electricity production. At this level, wind energy contribution can be equivalent to the current network primary control reserve, which causes balancing difficult. The share of wind energy is due to grow even further since the objective is set to reach 118 MW by 2020. It is an absolute evidence for the network operator that due to security concerns of the electrical grid, the share of wind generation should not increase unless solutions are found to solve the prediction problem. The University of French West-Indies and Guyana has developed a short-term wind energy prediction scheme that uses artificial neural networks and adaptive learning procedures based on Bayesian approach and Gaussian approximation. This paper reports the results of the evaluation of the proposed approach; the improvement with respect to the simple persistent prediction model was globally good. A discussion on how such a tool combined with energy storage capacity could help to smooth the wind power variation and improve the wind energy penetration rate into island utility network is also proposed.

Long-term affected energy production of waste to energy technologies identified by use of energy system analysis.

Science.gov (United States)

Münster, M; Meibom, P

2010-12-01

Affected energy production is often decisive for the outcome of consequential life-cycle assessments when comparing the potential environmental impact of products or services. Affected energy production is however difficult to determine. In this article the future long-term affected energy production is identified by use of energy system analysis. The focus is on different uses of waste for energy production. The Waste-to-Energy technologies analysed include co-combustion of coal and waste, anaerobic digestion and thermal gasification. The analysis is based on optimization of both investments and production of electricity, district heating and bio-fuel in a future possible energy system in 2025 in the countries of the Northern European electricity market (Denmark, Norway, Sweden, Finland and Germany). Scenarios with different CO(2) quota costs are analysed. It is demonstrated that the waste incineration continues to treat the largest amount of waste. Investments in new waste incineration capacity may, however, be superseded by investments in new Waste-to-Energy technologies, particularly those utilising sorted fractions such as organic waste and refuse derived fuel. The changed use of waste proves to always affect a combination of technologies. What is affected varies among the different Waste-to-Energy technologies and is furthermore dependent on the CO(2) quota costs and on the geographical scope. The necessity for investments in flexibility measures varies with the different technologies such as storage of heat and waste as well as expansion of district heating networks. Finally, inflexible technologies such as nuclear power plants are shown to be affected. Copyright © 2010 Elsevier Ltd. All rights reserved.

Current problems of the Bulgarian energy industry against the background of global short-term energy demand

International Nuclear Information System (INIS)

Batov, S.

1999-01-01

The energy demand during the next century due first of all to the expected growth of population necessitates more efficient technologies and huge investments. The production of nuclear energy requires higher safety as well as reduction of costs. A new form of partnership between the developed and developing countries is needed for transferring capital and technologies at special framework terms in order to avoid errors in the process of transition. The Energy Forum'99 highlights the current problems of Bulgarian energy branch and the projects for its future including better utilization of the existing energy resources, for development of new or renewable energy sources, not well utilized at present, and to harmonize the sector with better environmental protection. The most important problems discussed are: 1. Structure and restructuring strategy of the energy sector. Prices and tariffs. Privatization aspects. Construction of new replacement generating capacities; 2. Thermal power plants; 3. Nuclear power plants; 4. District heating and natural gas supply; 5. Efficient energy utilization; 6. Renewable energy sources; 7. Environmental protection and 8. Education

An Integrated Modeling Approach for Forecasting Long-Term Energy Demand in Pakistan

Directory of Open Access Journals (Sweden)

Syed Aziz Ur Rehman

2017-11-01

Full Text Available Energy planning and policy development require an in-depth assessment of energy resources and long-term demand forecast estimates. Pakistan, unfortunately, lacks reliable data on its energy resources as well do not have dependable long-term energy demand forecasts. As a result, the policy makers could not come up with an effective energy policy in the history of the country. Energy demand forecast has attained greatest ever attention in the perspective of growing population and diminishing fossil fuel resources. In this study, Pakistan’s energy demand forecast for electricity, natural gas, oil, coal and LPG across all the sectors of the economy have been undertaken. Three different energy demand forecasting methodologies, i.e., Autoregressive Integrated Moving Average (ARIMA, Holt-Winter and Long-range Energy Alternate Planning (LEAP model were used. The demand forecast estimates of each of these methods were compared using annual energy demand data. The results of this study suggest that ARIMA is more appropriate for energy demand forecasting for Pakistan compared to Holt-Winter model and LEAP model. It is estimated that industrial sector’s demand shall be highest in the year 2035 followed by transport and domestic sectors. The results further suggest that energy fuel mix will change considerably, such that oil will be the most highly consumed energy form (38.16% followed by natural gas (36.57%, electricity (16.22%, coal (7.52% and LPG (1.52% in 2035. In view of higher demand forecast of fossil fuels consumption, this study recommends that government should take the initiative for harnessing renewable energy resources for meeting future energy demand to not only avert huge import bill but also achieving energy security and sustainability in the long run.

40 CFR 152.168 - Advertising of restricted use products.

Science.gov (United States)

2010-07-01

... advertising. (5) Billboards and posters. (c) The requirement may be satisfied for printed material by... in the broadcast of the spoken words “Restricted use pesticide,” or a statement of the terms of...

Intermittent v. continuous energy restriction: differential effects on postprandial glucose and lipid metabolism following matched weight loss in overweight/obese participants.

Science.gov (United States)

Antoni, Rona; Johnston, Kelly L; Collins, Adam L; Robertson, M Denise

2018-03-01

The intermittent energy restriction (IER) approach to weight loss involves short periods of substantial (>70 %) energy restriction (ER) interspersed with normal eating. Studies to date comparing IER to continuous energy restriction (CER) have predominantly measured fasting indices of cardiometabolic risk. This study aimed to compare the effects of IER and CER on postprandial glucose and lipid metabolism following matched weight loss. In all, twenty-seven (thirteen male) overweight/obese participants (46 (sem 3) years, 30·1 (sem 1·0) kg/m2) who were randomised to either an IER intervention (2638 kJ for 2 d/week with an overall ER of 22 (sem 0·3) %, n 15) or a CER intervention (2510 kJ below requirements with overall ER of 23 (sem 0·8) %) completed the study. Postprandial responses to a test meal (over 360 min) and changes in anthropometry (fat mass, fat-free mass, circumferences) were assessed at baseline and upon attainment of 5 % weight loss, following a 7-d period of weight stabilisation. The study found no statistically significant difference in the time to attain a 5 % weight loss between groups (median 59 d (interquartile range (IQR) 41-80) and 73 d (IQR 48-128), respectively, P=0·246), or in body composition (P≥0·437). For postprandial measures, neither diet significantly altered glycaemia (P=0·266), whereas insulinaemia was reduced comparatively (P=0·903). The reduction in C-peptide tended (P=0·057) to be greater following IER (309 128 (sem23 268) to 247781 (sem20 709) pmol×360 min/l) v. CER (297 204 (sem25 112) to 301 655 (sem32 714) pmol×360 min/l). The relative reduction in TAG responses was greater (P=0·045) following IER (106 (sem30) to 68 (sem 15) mmol×360 min/l) compared with CER (117 (sem 43) to 130 (sem 31) mmol×360 min/l). In conclusion, these preliminary findings highlight underlying differences between IER and CER, including a superiority of IER in reducing postprandial lipaemia, which now warrant targeted mechanistic evaluation

A comparative study of long-term energy demand and potential greenhouse gas emission control in Bangladesh

International Nuclear Information System (INIS)

Khalaquazzaman, Mohammad

2005-02-01

This report presents a comparative study of long-term energy demand and potential greenhouse gas emissions projections from energy demand and supply sectors in Bangladesh covering the period 2000 to 2020. The study was conducted employing the IAEA's tool ENPEP- BALANCE model. This study presents a reliable energy system plan with minimal carbon emission for the country. Primary energy demands distributed by energy carriers and electricity demand have been projected based on macro-economic growth scenarios constructed for national energy policy of 1996. The conservation of indigenous energy resources was emphasized to build a long-term secured energy supply system. The potential energy supply options including nuclear energy and prospective greenhouse gas mitigation options were analyzed

Discussing Firearm Ownership and Access as Part of Suicide Risk Assessment and Prevention: "Means Safety" versus "Means Restriction".

Science.gov (United States)

Stanley, Ian H; Hom, Melanie A; Rogers, Megan L; Anestis, Michael D; Joiner, Thomas E

2017-01-01

The goal of this study was to describe the relative utility of the terms "means safety" versus "means restriction" in counseling individuals to limit their access to firearms in the context of a mock suicide risk assessment. Overall, 370 participants were randomized to read a vignette depicting a clinical scenario in which managing firearm ownership and access was discussed either using the term "means safety" or "means restriction." Participants rated the term "means safety" as significantly more acceptable and preferable than "means restriction." Participants randomized to the "means safety" condition reported greater intentions to adhere to clinicians' recommendations to limit access to a firearm for safety purposes (F[1,367] = 7.393, p = .007, [Formula: see text]). The term "means safety" may be more advantageous than "means restriction" when discussing firearm ownership and access in clinical settings and public health-oriented suicide prevention efforts.

Increased Protein Consumption during the Day from an Energy-Restricted Diet Augments Satiety but Does Not Reduce Daily Fat or Carbohydrate Intake on a Free-Living Test Day in Overweight Women.

Science.gov (United States)

Gwin, Jess A; Maki, Kevin C; Leidy, Heather J

2017-12-01

Background: Higher-protein (HP) energy-restriction diets improve weight management to a greater extent than normal-protein (NP) versions. Potential mechanisms of action with regard to assessment of eating behaviors across the day have not been widely examined during energy restriction. Objectives: The objectives of this study were to test whether the consumption of an HP energy-restriction diet reduces carbohydrate and fat intakes through improvements in daily appetite, satiety, and food cravings compared with NP versions and to test whether protein type within the NP diets alters protein-related satiety. Methods: Seventeen overweight women [mean ± SEM age: 36 ± 1 y; body mass index (kg/m 2 ): 28.4 ± 0.1] completed a randomized, controlled-feeding crossover study. Participants were provided with the following ∼1250-kcal/d energy-restricted (-750-kcal/d deficit) diets, each for 6 d: HP [124 g protein/d; 60% from beef and 40% from plant sources (HP-BEEF)] or NP (48 g protein/d) that was protein-type matched (NP-BEEF) or unmatched [100% from plant-based sources (NP-PLANT)]. On day 6 of each diet period, participants completed a 12-h testing day containing repetitive appetite, satiety, and food-craving questionnaires. On day 7, the participants were asked to consume their protein requirement within each respective diet but were provided with a surplus of carbohydrate- and fat-rich foods to consume, ad libitum, at each eating occasion across the day. All outcomes reported were primary study outcomes. Results: The HP-BEEF diet reduced daily hunger by 16%, desire to eat by 15%, prospective food consumption by 14%, and fast-food cravings by 15% but increased daily fullness by 25% compared with the NP-BEEF and NP-PLANT diets (all P protein throughout the day did not reduce the energy consumed ad libitum from the fat- and carbohydrate-rich foods (HP-BEEF: 2000 ± 180 kcal/d; NP-BEEF: 2120 ± 190 kcal/d; NP-PLANT: 2070 ± 180 kcal/d). None of the outcomes differed

Energy renovation of single-family houses in Denmark utilising long-term financing based on equity

DEFF Research Database (Denmark)

Kragh, Jesper; Rose, Jørgen

2011-01-01

This paper aims to present an economic overview of the opportunities for energy renovation of single-family houses in Denmark financed over the long term. The paper focuses on the economic difference between energy savings and the repayment of investment. Taking out the average remaining 20% equity...... in long-term property mortgage loans and utilising it for extensive energy renovation improves both the economy and the extent of included measures. Approximately 30% of energy consumption in Denmark is used for space heating. The existing 1 million single-family houses account for approximately half...

The water-water cycle in leaves is not a major alternative electron sink for dissipation of excess excitation energy when CO2 assimilation is restricted

NARCIS (Netherlands)

Driever, S.M.; Baker, N.R.

2011-01-01

Electron flux from water via photosystem II (PSII) and PSI to oxygen (water–water cycle) may provide a mechanism for dissipation of excess excitation energy in leaves when CO2 assimilation is restricted. Mass spectrometry was used to measure O2 uptake and evolution together with CO2 uptake in leaves

Validity of single term energy expression for ground state rotational band of even-even nuclei

International Nuclear Information System (INIS)

Sharma, S.; Kumar, R.; Gupta, J.B.

2005-01-01

Full text: There are large numbers of empirical studies of gs band of even-even nuclei in various mass regions. The Bohr-Mottelson's energy expression is E(I) = AX + BX 2 +CX 3 +... where X = I(I+1). The anharmonic vibrator energy expression is: E(I) = al + bl 2 + cl 3 SF model with energy expression: E(I)= pX + qI + rXI... where the terms represents the rotational, vibrational and R-V interaction energy, respectively. The validity f the various energy expressions with two terms had been tested by Sharma for light, medium and heavy mass regions using R I s. R 4 plots (where, spin I=6, 8, 10, 12), which are parameter independent. It was also noted, that of the goodness of energy expression can be judged with the minimum input of energies (i.e. only 2 parameters) and predictability's of the model p to high spins. Recently, Gupta et. al proposed a single term energy expression (SSTE) which was applied for rare earth region. This proposed power law reflected the unity of rotation - vibration in a different way and was successful in explaining the structure of gs-band. It will be useful for test the single term energy expression for light and heavy mass region. The single term expression for energy of ground state band can be written as: E I =axI b , where the index b and the coefficient a are the constant for the band. The values of b+1 and a 1 are as follows: b 1 =log(R 1 )/log(I/2) and a 1 =E I /I b ... The following results were gained: 1) The sharp variation in the value of index b at given spin will be an indication of the change in the shape of the nucleus; 2) The value of E I /I b is fairly constant with spin below back-bending, which reflects the stability of shape with spin; 3) This proposed power law is successful in explaining the structure of gs-band of nuclei

The electron energy distribution function of noble gases with flow

International Nuclear Information System (INIS)

Karditsas, P.J.

1989-01-01

The treatment of the Boltzmann equation by several investigators, for the determination of the electron energy distribution function (EEDF) in noble gases was restricted to static discharges. It is of great interest to magnetoplasmadynamic power generation to develop the Boltzmann equation to account for the effect of the bulk fluid flow on the EEDF. The two term expansion of the Boltzmann equation, as given, results in additional terms introduced to the equations due to the bulk fluid flow, with velocity u

Plasma nesfatin-1 is not affected by long-term food restriction and does not predict rematuration among iteroparous female rainbow trout (Oncorhynchus mykiss).

Science.gov (United States)

Caldwell, Lucius K; Pierce, Andrew L; Riley, Larry G; Duncan, Christine A; Nagler, James J

2014-01-01

The metabolic peptide hormone nesfatin-1 has been linked to the reproductive axis in fishes. The purpose of this study was to determine how energy availability after spawning affects plasma levels of nesfatin-1, the metabolic peptide hormone ghrelin, and sex steroid hormones in rematuring female rainbow trout (Oncorhynchus mykiss). To limit reproductive maturation, a group of female trout was food-restricted after spawning and compared with a control group that was fed a standard broodstock ration. The experiment was conducted twice, once using two-year-old trout (second-time spawners) and once using three-year-old trout (third-time spawners). During monthly sampling, blood was collected from all fish, and a subset of fish from each treatment was sacrificed for pituitaries. Pituitary follicle-stimulating hormone-beta (fsh-β) mRNA expression was analyzed with q-RT-PCR; plasma hormone levels were quantified by radioimmunoassay (17β-estradiol and ghrelin) and enzyme-linked immunosorbent assay (11-keto-testosterone and nesfatin-1). Although plasma nesfatin-1 levels increased significantly in the months immediately after spawning within both feeding treatments, plasma nesfatin-1 did not differ significantly between the two treatments at any point. Similarly, plasma ghrelin levels did not differ significantly between the two treatments at any point. Food restriction arrested ovarian development by 15-20 weeks after spawning, shown by significantly lower plasma E2 levels among restricted-ration fish. Pituitary fsh-β mRNA levels were higher among control-ration fish than restricted-ration fish starting at 20 weeks, but did not differ significantly between treatment groups until 30 weeks after spawning. Within both treatment groups, plasma 11-KT was elevated immediately after spawning and rapidly decreased to and persisted at low levels; starting between 20 and 25 weeks after spawning, plasma 11-KT was higher among control-ration fish than restricted-ration fish. The

Assessing Smart Grids contribution to the energy transition with long-term scenarios

International Nuclear Information System (INIS)

Bouckaert, Stephanie

2013-01-01

In the context of discussions on the energy transition, the general consensus is that part of the solution could come from Smart Grids to deal both with climate and energy issues. Prospective energy systems models may be used to estimate the long-term development of the energy system in order to meet future energy demands while taking into account environmental and technical constraints. These historical models are demand driven and should from now on evolve to considerate future developments of the electricity system. In this study, we have implemented some functionalities related to the concept of Smart Grids in a long-term planning model (demand-side integration, storage, renewable energy). This approach makes it possible to evaluate their benefits separately or collectively, taking into account possible interactions between these functionalities. We have also implemented an indicator reflecting the level of reliability of the electricity system in our model. This additional parameter enables to constrain future electricity systems to ensure a level of reliability identical to the existing one. Our analysis is demonstrated by the case of the Reunion Island, which aims to produce electricity using 100% renewable sources by 2030, and for which Smart Grids functionalities are also potential solutions for reaching this objective. (author) [fr

Restricted Interval Valued Neutrosophic Sets and Restricted Interval Valued Neutrosophic Topological Spaces

Directory of Open Access Journals (Sweden)

Anjan Mukherjee

2016-08-01

Full Text Available In this paper we introduce the concept of restricted interval valued neutrosophic sets (RIVNS in short. Some basic operations and properties of RIVNS are discussed. The concept of restricted interval valued neutrosophic topology is also introduced together with restricted interval valued neutrosophic finer and restricted interval valued neutrosophic coarser topology. We also define restricted interval valued neutrosophic interior and closer of a restricted interval valued neutrosophic set. Some theorems and examples are cites. Restricted interval valued neutrosophic subspace topology is also studied.

The term of danger in the surveillance procedure under atomic energy law

International Nuclear Information System (INIS)

Roller, G.

1993-01-01

Article 19 Section 3 of the Atomic Energy Law is gaining more and more practical significance. This can be seen from the dispute about the reach of the term of danger under atomic energy law, among other issues. The article examines the prerequisites for an offence pursuant to Article 19 Section 3 of the Atomic Energy Law - danger, suspected danger, 'acute' danger - and then goes on to deal with the term of danger as concretized by sublegislative rulings - concept of predefined accidents as an interpretative aid, their significance in the context of taking precautions against damage, consequences of the uncontrollability of such accidents. The legal consequences of this include the authorities' discretion when and how to act, exept for cases of grave danger where this discretion is reduced 'to zero', i.e. the authority is compelled to act. (orig./HSCH) [de

Changes in body weight, blood pressure and selected metabolic biomarkers with an energy-restricted diet including twice daily sweet snacks and once daily sugar-free beverage

OpenAIRE

Nickols-Richardson, Sharon M.; Piehowski, Kathryn E.; Metzgar, Catherine J.; Miller, Debra L.; Preston, Amy G.

2014-01-01

BACKGROUND/OBJECTIVES The type of sweet snack incorporated into an energy-restricted diet (ERD) may produce differential effects on metabolic improvements associated with body weight (BW) loss. This study compared effects of incorporating either twice daily energy-controlled dark chocolate snacks plus once daily sugar-free cocoa beverage (DC) to non-chocolate snacks plus sugar-free non-cocoa beverage (NC) into an ERD on BW loss and metabolic outcomes. MATERIALS/METHODS In an 18-week randomize...

Restricted flows of soliton hierarchies: coupled KdV and Harry-Dym case

International Nuclear Information System (INIS)

Antonowicz, M.; Rauch-Wojciechowski, S.

1991-01-01

Restricted flows of soliton hierarchies associated to the energy dependent Schroedinger spectral problem are determined explicitely. A remarkable connection with separable potentials is used for proving complete integrability of the restricted flows. A previously unknown lagrangian and hamiltonian formulation of the Neumann system is found. Whole families of generalizations of the Neumann and Garnier systems are given. (au)

Intrauterine growth-restricted sheep fetuses exhibit smaller hindlimb muscle fibers and lower proportions of insulin-sensitive Type I fibers near term.

Science.gov (United States)

Yates, Dustin T; Cadaret, Caitlin N; Beede, Kristin A; Riley, Hannah E; Macko, Antoni R; Anderson, Miranda J; Camacho, Leticia E; Limesand, Sean W

2016-06-01

Intrauterine growth restriction (IUGR) reduces muscle mass and insulin sensitivity in offspring. Insulin sensitivity varies among muscle fiber types, with Type I fibers being most sensitive. Differences in fiber-type ratios are associated with insulin resistance in adults, and thus we hypothesized that near-term IUGR sheep fetuses exhibit reduced size and proportions of Type I fibers. Placental insufficiency-induced IUGR fetuses were ∼54% smaller (P fetal muscles develop smaller fibers and have proportionally fewer Type I fibers, which is indicative of developmental adaptations that may help explain the link between IUGR and adulthood insulin resistance. Copyright © 2016 the American Physiological Society.

Existing Whole-House Solutions Case Study: Group Home Energy Efficiency Retrofit for 30% Energy Savings, Washington, D.C.

Energy Technology Data Exchange (ETDEWEB)

None

2013-11-01

Energy efficiency retrofits (EERs) face many challenges on the path to scalability. Limited budgets, cost effectiveness, risk factors, and accessibility impact the type and the extent of measures that can be implemented feasibly to achieve energy savings goals. Group home retrofits can face additional challenges than those in single family homes – such as reduced access (occupant-in-place restrictions) and lack of incentives for occupant behavioral change. This project studies the specification, implementation, and energy savings from an EER in a group home, with an energy savings goal of 30%. This short term test report chronicles the retrofit measures specified, their projected cost-effectiveness using building energy simulations, and the short term test results that were used to characterize pre-retrofit and post-retrofit conditions. Additionally, the final report for the project will include analysis of pre- and post-retrofit performance data on whole building energy use, and an assessment of the energy impact of occupant interface with the building (i.e., window operation). Ultimately, the study’s results will be used to identify cost effective EER measures that can be implemented in group homes, given constraints that are characteristic of these buildings. Results will also point towards opportunities for future energy savings.

Occupant-in-Place Energy Efficiency Retrofit in a Group Home for 30% Energy Savings in Climate Zone 4

Energy Technology Data Exchange (ETDEWEB)

Moore, M.

2013-08-01

Energy efficiency retrofits (EERs) face many challenges on the path to scalability. Limited budgets, cost effectiveness, risk factors, and accessibility impact the type and the extent of measures that can be implemented feasibly to achieve energy savings goals. Group home retrofits can face additional challenges than those in single family homes - such as reduced access (occupant-in-place restrictions) and lack of incentives for occupant behavioral change. This project studies the specification, implementation, and energy savings from an EER in a group home, with an energy savings goal of 30%. This short term test report chronicles the retrofit measures specified, their projected cost-effectiveness using building energy simulations, and the short term test results that were used to characterize pre-retrofit and post-retrofit conditions. Additionally, the final report for the project will include analysis of pre- and post-retrofit performance data on whole building energy use, and an assessment of the energy impact of occupant interface with the building (i.e., window operation). Ultimately, the study's results will be used to identify cost effective EER measures that can be implemented in group homes, given constraints that are characteristic of these buildings. Results will also point towards opportunities for future energy savings.

Occupant-in-Place Energy Efficiency Retrofit in a Group Home for 30% Energy Savings in Climate Zone 4

Energy Technology Data Exchange (ETDEWEB)

Moore, Mike [Building America Partnership for Improved Residential Construction (BA-PIRC), Cocoa, FL (United States)

2013-08-01

Energy efficiency retrofits (EERs) face many challenges on the path to scalability. Limited budgets, cost effectiveness, risk factors, and accessibility impact the type and the extent of measures that can be implemented feasibly to achieve energy savings goals. Group home retrofits can face additional challenges than those in single family homes – such as reduced access (occupant-in-place restrictions) and lack of incentives for occupant behavioral change. This project studies the specification, implementation, and energy savings from an EER in a group home, with an energy savings goal of 30%. This short term test report chronicles the retrofit measures specified, their projected cost effectiveness using building energy simulations, and the short term test results that were used to characterize pre-retrofit and post-retrofit conditions. Additionally, the final report for the project will include analysis of pre- and post-retrofit performance data on whole building energy use, and an assessment of the energy impact of occupant interface with the building (i.e., window operation). Ultimately, the study’s results will be used to identify cost-effective EER measures that can be implemented in group homes, given constraints that are characteristic of these buildings. Results will also point towards opportunities for future energy savings.

Extracting the σ-term from low-energy pion-nucleon scattering

Science.gov (United States)

Ruiz de Elvira, Jacobo; Hoferichter, Martin; Kubis, Bastian; Meißner, Ulf-G.

2018-02-01

We present an extraction of the pion-nucleon (π N) scattering lengths from low-energy π N scattering, by fitting a representation based on Roy-Steiner equations to the low-energy data base. We show that the resulting values confirm the scattering-length determination from pionic atoms, and discuss the stability of the fit results regarding electromagnetic corrections and experimental normalization uncertainties in detail. Our results provide further evidence for a large π N σ-term, {σ }π N=58(5) {{MeV}}, in agreement with, albeit less precise than, the determination from pionic atoms.

Developmental Programming of Cardiovascular Disease Following Intrauterine Growth Restriction: Findings Utilising A Rat Model of Maternal Protein Restriction

Science.gov (United States)

Zohdi, Vladislava; Lim, Kyungjoon; Pearson, James T.; Black, M. Jane

2014-01-01

Over recent years, studies have demonstrated links between risk of cardiovascular disease in adulthood and adverse events that occurred very early in life during fetal development. The concept that there are embryonic and fetal adaptive responses to a sub-optimal intrauterine environment often brought about by poor maternal diet that result in permanent adverse consequences to life-long health is consistent with the definition of “programming”. The purpose of this review is to provide an overview of the current knowledge of the effects of intrauterine growth restriction (IUGR) on long-term cardiac structure and function, with particular emphasis on the effects of maternal protein restriction. Much of our recent knowledge has been derived from animal models. We review the current literature of one of the most commonly used models of IUGR (maternal protein restriction in rats), in relation to birth weight and postnatal growth, blood pressure and cardiac structure and function. In doing so, we highlight the complexity of developmental programming, with regards to timing, degree of severity of the insult, genotype and the subsequent postnatal phenotype. PMID:25551250

38 CFR 36.4362 - Rights and restrictions.

Science.gov (United States)

2010-07-01

... parking areas or facilities. (ii) Any contract or lease, including franchises and licenses, to which a declarant is a party. (iii) The requirements of paragraphs (a)(2)(i) and (ii) of this section do not apply... restrictions are acceptable: (i) A requirement that leases have a minimum initial term of up to 1 year; or (ii...

Screening, diagnosis, and management of intrauterine growth restriction.

Science.gov (United States)

Lausman, Andrea; McCarthy, Fergus P; Walker, Melissa; Kingdom, John

2012-01-01

To provide comprehensive background knowledge relevant to the SOGC Maternal-Fetal Medicine Committee-approved guideline entitled "Intrauterine Growth Restriction: Screening, Diagnosis, and Management." Publications in English were retrieved through searches of PubMed or Medline, CINAHL, and the Cochrane Library in January 2011 using appropriate controlled vocabulary via MeSH terms (fetal growth restriction and small for gestational age) and any key words (fetal growth, restriction, growth retardation, intrauterine growth restriction [IUGR], low birth weight, small for gestational age). Results were restricted to systematic reviews, randomized controlled trials or controlled clinical trials, and high-quality prospective and retrospective observational studies. Grey (unpublished) literature was identified through searching the websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies. Evidence obtained from at least one properly randomized controlled trial, Cochrane Reviews, and high quality cohort data have been combined to provide clinicians with evidence to optimize their practice for screening, diagnosis, and management of intrauterine growth restriction. Considerable advances have been made to improve clinicians' ability to screen, diagnose, and manage pregnancies with suspected IUGR more effectively, including several properly randomized controlled trials. Pregnancies with late-onset IUGR may be managed equally effectively by early delivery or delayed delivery (with increased surveillance) anticipating favourable outcomes. By contrast, many aspects of the management of early-onset IUGR require further clinical trials.

Food restriction causes low bone strength and microarchitectural deterioration in exercised growing male rats.

Science.gov (United States)

Hattori, Satoshi; Park, Jong-Hoon; Agata, Umon; Oda, Masaya; Higano, Michito; Aikawa, Yuki; Akimoto, Takayuki; Nabekura, Yoshiharu; Yamato, Hideyuki; Ezawa, Ikuko; Omi, Naomi

2014-01-01

The pathogenesis of bone disorders in young male athletes has not been well understood. We hypothesized that bone fragility is caused by low energy availability, due to insufficient food intake and excessive exercise energy expenditure in young male athletes. To examine this hypothesis, we investigated the influence of food restriction on bone strength and bone morphology in exercised growing male rats, using three-point bending test, dual-energy X-ray absormetry, and micro-computed tomography. Four-week-old male Sprague-Dawley rats were divided randomly into the following groups: the control (Con) group, exercise (Ex) group, food restriction (R) group, and food restriction plus exercise (REx) group after a 1-wk acclimatization period. Thirty-percent food restriction in the R and REx groups was carried out in comparison with that in the Con group. Voluntary running exercise was performed in the Ex and REx groups. The experimental period lasted 13 wk. At the endpoint of this experiment, the bone strength of the femurs and tibial BMD in the REx group were significantly lower than those in the Con group. Moreover, trabecular bone volume and cortical bone volume in the REx group were also significantly lower than those in the Con group. These findings indicate that food restriction causes low bone strength and microarchitectural deterioration in exercised growing male rats.

Mexico's long-term energy outlook : results of a detailed energy supply and demand simulation

International Nuclear Information System (INIS)

Conzelmann, G.; Quintanilla, J.; Conde, L.A.; Fernandez, J.; Mar, E.; Martin del Campo, C.; Serrato, G.; Ortega, R.

2006-01-01

This article discussed the results of a bottom-up analysis of Mexico's energy markets which was conducted using an energy and power evaluation program. The program was used to develop energy market forecasts to the year 2025. In the first phase of the study, dynamic optimization software was used to determine the optimal, least-cost generation system expansion path to meet growing demand for electricity. A separate model was used to determine the optimal generating strategy of mixed hydro-thermal electric power systems. In phase 2, a nonlinear market-based approach was used to determine the energy supply and demand balance for the entire energy system, as well as the response of various segments of the energy system to changes in energy price and demand levels. Basic input parameters included information on the energy system structure; base-year energy statistics; and, technical and policy constraints. A total of 14 scenarios were modelled to examine variations in load growth, sensitivities to changes in projected fuel prices, variations in assumed natural gas availability, system reliability targets, and the potential for additional nuclear capacity. Forecasts for the entire energy system were then developed for 4 scenarios: (1) reference case; (2) limited gas scenario; (3) renewable energy; and (4) additional nuclear power generation capacity. Results of the study showed that Mexico's crude oil production is projected to increase annually by 1 per cent to 2025. Imports of petroleum products resulting from the country's rapidly growing transportation sector will increase. Demand for natural gas is expected to outpace projected domestic production. The long-term market outlook for Mexico's electricity industry shows a heavy reliance on natural gas-based generating technologies. It was concluded that alternative results for a constrained-gas scenario showed a substantial shift to coal-based generation and associated effects on the natural gas market. 4 refs., 26

Transmission of the PabI family of restriction DNA glycosylase genes: mobility and long-term inheritance.

Science.gov (United States)

Kojima, Kenji K; Kobayashi, Ichizo

2015-10-19

R.PabI is an exceptional restriction enzyme that functions as a DNA glycosylase. The enzyme excises an unmethylated base from its recognition sequence to generate apurinic/apyrimidinic (AP) sites, and also displays AP lyase activity, cleaving the DNA backbone at the AP site to generate the 3'-phospho alpha, beta-unsaturated aldehyde end in addition to the 5'-phosphate end. The resulting ends are difficult to religate with DNA ligase. The enzyme was originally isolated in Pyrococcus, a hyperthermophilic archaeon, and additional homologs subsequently identified in the epsilon class of the Gram-negative bacterial phylum Proteobacteria, such as Helicobacter pylori. Systematic analysis of R.PabI homologs and their neighboring genes in sequenced genomes revealed co-occurrence of R.PabI with M.PabI homolog methyltransferase genes. R.PabI and M.PabI homolog genes are occasionally found at corresponding (orthologous) loci in different species, such as Helicobacter pylori, Helicobacter acinonychis and Helicobacter cetorum, indicating long-term maintenance of the gene pair. One R.PabI and M.PabI homolog gene pair is observed immediately after the GMP synthase gene in both Campylobacter and Helicobacter, representing orthologs beyond genera. The mobility of the PabI family of restriction-modification (RM) system between genomes is evident upon comparison of genomes of sibling strains/species. Analysis of R.PabI and M.PabI homologs in H. pylori revealed an insertion of integrative and conjugative elements (ICE), and replacement with a gene of unknown function that may specify a membrane-associated toxin (hrgC). In view of the similarity of HrgC with toxins in type I toxin-antitoxin systems, we addressed the biological significance of this substitution. Our data indicate that replacement with hrgC occurred in the common ancestor of hspAmerind and hspEAsia. Subsequently, H. pylori with and without hrgC were intermixed at this locus, leading to complex distribution of hrgC in East

Survey and research on patent and information. Survey of standard terms (Hydrogen energy); Kijun yogo chosa tokkyo joho chosa kenkyu. Suiso energy (kento shiryo)

Energy Technology Data Exchange (ETDEWEB)

NONE

1981-03-01

Collected in this glossary are terms for use in the development of hydrogen energy technologies. This glossary has been compiled, in view of the current situation where terms are used without standardization or distinction in various recent reports and publications relating to the development of hydrogen energy technologies, to prevent confusion and to help enhance research and development under the Sunshine Program. This is a 3-year endeavor that was started in 1979, undertaken by a committee consisting mainly of men of learning and experience representing organizations associated with the Sunshine Program. The terms are collected from research achievement reports and other materials covering the period of fiscal 1974-1979 relating to hydrogen energy projects under the Sunshine Program. Approximately 200 terms were picked up in the first fiscal year, and 85 in the second fiscal year. Attached to each of the Japanese terms are the pronunciation, a corresponding English term, and a brief explanation in the Japanese language. (NEDO)

Optimization of offshore wind farm layout in restricted zones

International Nuclear Information System (INIS)

Hou, Peng; Hu, Weihao; Chen, Cong; Soltani, Mohsen; Chen, Zhe

2016-01-01

In this research, an optimization method for offshore wind farm layout design is proposed. With the purpose of maximizing the energy production of the wind farm, the wind turbine (WT) positions are optimized. Due to the limitations of seabed conditions, marine traffic limitations or shipwrecks, etc., the WTs are expected to be placed outside specific areas. Based on this fact, a restriction zone concept is proposed in this paper and implemented with the penalty function method. In order to find a feasible solution, a recent proposed stochastic algorithm, particle swarm optimization algorithm with multiple adaptive methods (PSO-MAM) is adopted. The simulation results indicate that the proposed method can find a layout which outperforms a baseline layout of a reference wind farm (RWF) by increasing the energy yield by 3.84%. - Highlights: • The offshore restricted area concept is proposed. • The recent developed PSO-MAM algorithm is arranged to optimize the layout. • The penalty function method is adopted to help find the feasible solution. • The optimized layout increases energy yields 3.84% than reference wind farm.

Biochemical Mechanisms and Energy Strategies of Geobacter sulfurreducens for Long- Term Survival

Science.gov (United States)

Helmus, R. A.; Liermann, L. J.; Brantley, S. L.; Tien, M.

2008-12-01

Numerous species of bacteria have been observed to exhibit a growth advantage in stationary phase (GASP) phenotype, indicating that microorganisms starved of an energy source may adapt to allow for long-term survival. Understanding how Geobacter sulfurreducens persists using various metal forms as energy sources and whether a GASP phenotype develops during long-term growth are important for efficient application of this bacterium to sites requiring engineered bioremediation of soluble metals. Thus, we investigated the growth kinetics and survival of G. sulfurreducens. The growth rate of G. sulfurreducens was highest when cultured with soluble iron and generally higher on iron oxide than manganese oxide, suggesting that soluble metal forms are more readily utilized as energy sources by G. sulfurreducens. By monitoring the abundance of G. sulfurreducens in batch cultures for >6 months, distinct growth, stationary, and prolonged starvation phases were observed and a cell density of 105- 106 cells/mL persisted under long-term starvation conditions. The outgrowth of an aged G. sulfurreducens strain co-cultured with a young strain was monitored as a measure of the existence of the GASP phenotype. As the strains aged, the rpoS gene was cloned and sequenced at different stages of growth to identify mutations corresponding to a growth advantage. The results of these studies provide insight into the use of various metal forms for growth by G. sulfurreducens and its ability to persist when starved of energy sources.

Effect of North Carolina's restriction on teenage driver cell phone use two years after implementation.

Science.gov (United States)

Goodwin, Arthur H; O'Brien, Natalie P; Foss, Robert D

2012-09-01

A majority of states now restrict teenagers from using a mobile communication device while driving. The effect of these restrictions is largely unknown. In a previous study, we found North Carolina's teenage driver cell phone restriction had little influence on young driver behavior four months after the law took effect (Foss et al., 2009). The goal of the present study was to examine the longer-term effect of North Carolina's cell phone restriction. It was expected that compliance with the restriction would increase, as awareness of the restriction grew over time. Teenagers were observed at high schools in North Carolina approximately two years after the law was implemented. Observations were also conducted in South Carolina, which did not have a cell phone restriction. In both states, there was a broad decrease in cell phone use. A logistic regression analysis showed the decrease in cell phone use did not significantly differ between the two states. Although hand-held cell phone use decreased, there was an increase in the likelihood that drivers in North Carolina were observed physically manipulating a phone. Finally, a mail survey of teenagers in North Carolina showed awareness for the cell phone restriction now stands at 78% among licensed teens. Overall, the findings suggest North Carolina's cell phone restriction has had no long-term effect on the behavior of teenage drivers. Moreover, it appears many teenage drivers may be shifting from talking on a phone to texting. Copyright © 2012 Elsevier Ltd. All rights reserved.

Energy Efficiency Market Report 2013: Market Trends and Medium-Term Prospects

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-07-01

Energy efficiency has been referred to as a ''hidden fuel'', one that extends energy supplies, increases energy security, lowers carbon emissions and generally supports sustainable economic growth. Yet it is hiding in plain sight: in 2011, investments in the energy efficiency market globally were at a similar scale to those in renewable energy or fossil-fuel power generation. The Energy Efficiency Market Report provides a practical basis for understanding energy efficiency market activities, a review of the methodological and practical challenges associated with measuring the market and its components, and statistical analysis of energy efficiency and its impact on energy demand. It also highlights a specific technology sector in which there is significant energy efficiency market activity, in this instance appliances and ICT. The report presents a selection of country case studies that illustrate current energy efficiency markets in specific sectors, and how they may evolve in the medium term. The energy efficiency market is diffuse, varied and involves all energy-consuming sectors of the economy. A comprehensive overview of market activity is complicated by the challenges associated with quantifying the components of the market and the paucity of comparable reported data. This report underscores how vital high-quality and timely energy efficiency data is to understanding this market.

A long-term, integrated impact assessment of alternative building energy code scenarios in China

International Nuclear Information System (INIS)

Yu, Sha; Eom, Jiyong; Evans, Meredydd; Clarke, Leon

2014-01-01

China is the second largest building energy user in the world, ranking first and third in residential and commercial energy consumption. Beginning in the early 1980s, the Chinese government has developed a variety of building energy codes to improve building energy efficiency and reduce total energy demand. This paper studies the impact of building energy codes on energy use and CO 2 emissions by using a detailed building energy model that represents four distinct climate zones each with three building types, nested in a long-term integrated assessment framework GCAM. An advanced building stock module, coupled with the building energy model, is developed to reflect the characteristics of future building stock and its interaction with the development of building energy codes in China. This paper also evaluates the impacts of building codes on building energy demand in the presence of economy-wide carbon policy. We find that building energy codes would reduce Chinese building energy use by 13–22% depending on building code scenarios, with a similar effect preserved even under the carbon policy. The impact of building energy codes shows regional and sectoral variation due to regionally differentiated responses of heating and cooling services to shell efficiency improvement. - Highlights: • We assessed long-term impacts of building codes and climate policy using GCAM. • Building energy codes would reduce Chinese building energy use by 13–22%. • The impacts of codes on building energy use vary by climate region and sub-sector

Formulating an optimal long-term energy supply strategy for Syria using MESSAGE model

International Nuclear Information System (INIS)

Hainoun, A.; Seif Aldin, M.; Almoustafa, S.

2010-01-01

An optimal long-term energy supply strategy has been formulated based on minimizing the total system costs for the entire study period 2003-2030. The national energy chain was modelled covering all energy levels and conversion technologies. The results indicate that the primary energy will grow at annual average rate of 4.8% arriving 68 Mtoe in 2030. The total installed electric capacity will be optimally expanded from 6885 to 19500 MW in 2030. Furthermore, to ensure supply security the future national energy system will rely mainly upon oil and natural gas (NG) with limited contribution of renewables and nuclear to the end of study period. The share of NG will increase gradually up to 2020 and then retreat. Owing to the continuous decrease of oil production, oil export is expected to vanish in 2012 and the country will import about 63% of its primary energy demand in 2030. Thus, the expected long-term development of national energy sector indicates a hard challenge for the future national economy. The employing of sensitivity analysis clarifies the importance of wind turbines operation time and discount rate. The analysis proves that nuclear option is insensitive to overnight cost increase up to 85% of the reference case value.

Data Input and Content Exploration in Scenarios with Restrictions

NARCIS (Netherlands)

D.C. Pedrosa

2014-01-01

htmlabstractAs technology evolves, new devices and interaction techniques are developed. These transformations create several challenges in terms of usability and user experience. Our research faces some challenges for data input or content exploration in scenarios with restrictions. It is not our

European energy security analysing the EU-Russia energy security regime in terms of interdependence theory